WorldWideScience

Sample records for relevance requirement pursuant

  1. 29 CFR 516.21 - Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b)(3) of the Act. 516.21 Section 516.21 Labor Regulations Relating to Labor....21 Bulk petroleum employees partially exempt from overtime pay requirements pursuant to section 7(b...

  2. Practical Relevance of Experiments in Comprehensibility of Requirements Specifications

    NARCIS (Netherlands)

    Condori-Fernandez, Nelly; Daneva, Maia; Sikkel, Nicolaas; Herrmann, Andrea

    2011-01-01

    Recently, the Requirements Engineering (RE) community has become increasingly aware of the importance of carrying out industry-relevant research. Researchers and practitioners should be able to evaluate the relevance of their empirical research to increase the likely adoption of RE methods in

  3. Pulmonary embolism. Clinical relevance, requirements for diagnostic and therapeutic strategies

    International Nuclear Information System (INIS)

    Nowak, F.G.; Halbfass, P.; Hoffmann, E.

    2007-01-01

    In the population the annual incidence of pulmonary embolism amounts to 1.3-2.8 per 1000 at the age of 65-89 years. Mortality reaches about 17% within the first 3 months. Acute pulmonary embolism is characterized by an increase in pulmonary arterial pressure and an impairment of the pulmonary gas exchange. Elevation of the right cardiac pressure up to right heart decompensation may follow. In addition, hypoxemia, hyperventilation, dead space ventilation, right to left shunting, bronchoconstriction, and vasoconstriction may occur. Clinical examination, ECG, laboratory findings such as elevated D-dimer, blood gas analysis, ultrasound examination of the veins of the lower extremities, and transthoracic echocardiography are acutely available diagnostic methods of an emergency department. In addition, extensive diagnostic procedures like pulmonary scintigraphy and pulmonary angiography may be required. The aim is to get a definite diagnosis as quickly as possible to direct therapy. In acute pulmonary embolism with cardiac shock, monitoring and stabilization of the circulatory function as well as an appropriate anticoagulant therapy are essential. In some cases surgery or a local fibrinolytic intervention is indicated. (orig.) [de

  4. 76 FR 51973 - Notice of Regional Waiver Pursuant to Section 1605 (Buy American Requirement) of the American...

    Science.gov (United States)

    2011-08-19

    ... (Buy American Requirement) of the American Recovery and Reinvestment Act of 2009, to Mason County, WA... is in the public interest to allow Mason County, Washington (the County) to utilize and install six... aeration blower units that have already been delivered to the construction site as noted in Mason County's...

  5. Catalog of CERCLA applicable or relevant and appropriate requirements (ARARs) - fact sheets

    Energy Technology Data Exchange (ETDEWEB)

    1990-07-01

    Section 121(d) of the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), requires attainment of federal and state applicable or relevant and appropriate requirements (ARARs). Subpart E, Section 300.400(g) {open_quotes}Identification of applicable or relevant and appropriate requirements{close_quotes} of the National Oil and Hazardous Substances Pollution Contingency Plan (NCP)(55 FR 8666, March 8, 1990) describes the process for attaining ARARs. The purpose of this catalog is to provide DOE Program Offices and Field Organizations with all of the {open_quotes}Quick Reference Fact Sheets{close_quotes} on attaining ARARS. These fact sheets provide overviews of ARARs for CERCLA cleanup actions pertinent to DOE environmental restoration activities. All of the fact sheets in this catalog were prepared by the Environmental Protection Agency`s Office of Solid Waste and Emergency Response. Fact sheets 1-7 discuss land disposal restrictions (LDRs) and their applicability. LDRs may pertain to a number of CERCLA response actions at DOE facilities. Fact Sheets 8-13 are based on the CERCLA Compliance with Other Laws Manual: Parts I and II and provide an overview of many other CERCLA ARARs. Overview of ARARs-Focus on ARAR Waivers (fact sheet 11), provides a good introduction to ARARS. The last two fact sheets, 14 and 15, are periodic reports that describe additional fact sheets and clarify issues.

  6. Environmental restoration disposal facility applicable or relevant and appropriate requirements study report. Revision 00

    International Nuclear Information System (INIS)

    Roeck, F.V.; Vedder, B.L.; Rugg, J.E.

    1995-10-01

    The Environmental Restoration Disposal Facility (ERDF) will be a landfill authorized under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) and will comply with the Resource Conservation and Recovery Act of 1976 (RCRA) substantive requirements. The facility will also comply with applicable or relevant and appropriate requirements (ARAR), including portions of the U.S. Environmental Protection Agency (EPA) regulations, Washington Administrative Code (WAC), and to-be-considered (TBC) elements such as U.S. Department of Energy (DOE) Orders. In considering the requirements of CERCLA, a detailed analysis of various alternatives for ERDF was completed using the nine CERCLA criteria, National Environmental Policy Act of 1969 (NEPA), and public comments. The ERDF record of decision (ROD) selected an alternative that includes a RCRA-compliant double-lined trench for the disposal of radioactive, hazardous, and mixed wastes resulting from the remediation of operable units (OU) within the National Priorities List (NPL) sites in the 100, 200, and 300 Areas. Only wastes resulting from the remediation of Hanford NPL sites will be allowed in the ERDF. Of the various siting and design alternatives proposed for ERDF, the selected alternative provides the best combination of features by balancing the nine CERCLA criteria, ARAR compliance, environmentally protective site, and various stakeholder and public recommendations. The ERDF trench design, compliant with RCRA Subtitle C minimum technical requirements (MTR), will be double lined and equipped with a leachate collection system. This design provides a more reliable system to protect groundwater than other proposed alternatives. The ERDF is located on the Hanford Site Central Plateau, southeast of the 200 West Area

  7. Shifts in foci and priorities. Different relevance of requirements to changing goals yields conflicting priorizations and is viewpoint-dependent.

    NARCIS (Netherlands)

    Hoorn, J.F.; Breuker, M.E.; Kok, E.

    2006-01-01

    Stakeholders judge goal relevance and software-development project requirements differently, considering them from a business versus a personal viewpoint. Three empirical studies provided evidence that stakeholders' personal goals for a system are valued higher than business goals and that,

  8. Shifts in foci and priorities. Different relevance of requirements to changing goals yields conflicting prioritizations and is viewpoint-dependent

    NARCIS (Netherlands)

    Hoorn, J.F.; Breuker, M.E.; Kok, E.

    2006-01-01

    Stakeholders judge goal relevance and software-development project requirements differently, considering them from a business versus a personal viewpoint. Three empirical studies provided evidence that stakeholders' personal goals for a system are valued higher than business goals and that,

  9. 17 CFR 249.619 - Form TA-Y2K, information required of transfer agents pursuant to section 17 of the Securities...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form TA-Y2K, information... Certain Exchange Members, Brokers, and Dealers § 249.619 Form TA-Y2K, information required of transfer... affecting Form TA-Y2K, see the List of CFR Sections Affected, which appears in the Finding Aids section of...

  10. 17 CFR 249.618 - Form BD-Y2K, information required of broker-dealers pursuant to section 17 of the Securities...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form BD-Y2K, information... Exchange Members, Brokers, and Dealers § 249.618 Form BD-Y2K, information required of broker-dealers... FR 37674, July 13, 1998] Editorial Note: For Federal Register citations affecting Form BD-Y2K, see...

  11. Analysis of interoperability requirements and of relevant activities in standards bodies and fora

    DEFF Research Database (Denmark)

    Guarneri, R.; Skouby, Knud Erik; Falch, Morten

    1999-01-01

    The aim of this deliverable is to provide the summary of the standardisation activities considered of most relevance for the work of the PRIME project with respect to interoperability; this information is of prime importance for the planning of further PRIME technical work in this area....

  12. Experiences in Using Practitioner’s Checklists to Evaluate the Relevance of Experiments Reported in Requirements Engineering

    NARCIS (Netherlands)

    Daneva, Maia; Sikkel, Nicolaas; Condori-Fernandez, Nelly; Herrmann, Andrea

    Background: Requirements Engineering (RE) researchers recognize that for RE methods to be adopted in industry, practitioners should be able to evaluate the relevance of a study to their practice. Kitchenham et al proposed a set of perspective-based checklists, which demonstrated to be a useful

  13. The Relevance of Vocational High School Curriculum with the Requirement of the Heavy Equipment Industries

    Science.gov (United States)

    Asfiyanur, E. P.; Sumardi, K.; Rahayu, Y.; Putra, R. C.

    2018-02-01

    This study aims to determine the relevance of competencies developed by vocational high schools with the needs of workers in the industrial world. This is to answer the statement from the world of industry that the competencies possessed by vocational secondary education graduates are not in accordance with industry standards. This research is a qualitative research conducted by collecting data, presenting accurate and objective information. Respondents of this research are industrial institutions in the field of heavy equipment, vocational education institutions and government agencies in charge of manpower. Selection of informants / sources of information used is purposive sample technique, which aims to give consideration to select informants who meet the criteria in providing accurate information. The results of this study provide insight and input to vocational secondary education managers about various information in developing vocational secondary education curriculum, major issues include curriculum content relevance, technological advances in the heavy equipment industry, updating of school facilities and collaboration between educational institutions and labor institutions and the industrial world in the development of vocational secondary education.

  14. Review of regulatory requirements relevant to calibration of monitoring instruments in research reactors

    Energy Technology Data Exchange (ETDEWEB)

    Gomaa, Hassan; Khedr, Ahmed; El-Din Talha, Kamal [Egyptian Nuclear and Radiological Regulatory Authority, Cairo (Egypt). Nuclear Safety Engineering Dept.

    2015-05-15

    The objective of this work is to demonstrate the regulatory requirements pertaining to calibration of monitoring instruments in research reactors. The regulatory statements concerning this subject in IAEA safety standards and the implementation of such regulations in twelve countries with different levels of nuclear programs are surveyed: Australia, Bulgaria, Canada, Egypt, Finland, Germany, Hungary, Slovenia, South Korea, Spain, United Kingdom of England and United States of America. In addition, the requirements of ISO/IEC17025 and NUPIC (Nuclear Utilities Procurement Issues Committee) are compared. Seven technical and administrate aspects are suggested as the comparison criteria and the explicit expression of the statements, the level of document (i.e.: act, requirement or guide) are the considered resources. The main differences and similarities between the different approaches are identified in order to provide an input for future development of the national regulations.

  15. Is comprehensive income required by IAS 1 relevant for users? A review of the literature

    OpenAIRE

    Le Manh-Béna , Anne

    2009-01-01

    Professional accountants have accepted for decades net income a the key performance measure of a business. The IASB decision in 2007 to require the publication of comprehensive income as it has been the case since 1997 in the United States, has fed the long time debate regarding the concept of income. In this paper, we will go through some background about both approaches of income and their consequences in terms of financial reporting. We will then review the related literature, classified a...

  16. Mobile health systems for bipolar disorder: the relevance of non-functional requirements in MONARCA project

    DEFF Research Database (Denmark)

    Mayora, Oscar; Frost, Mads; Arnrich, Bert

    2016-01-01

    This paper presents a series of challenges for developing mobile health solutions for mental health as a result of MONARCA project three-year activities. The lessons learnt on the design, development and evaluation of a mobile health system for supporting the treatment of bipolar disorder....... The findings presented here are the result of over 3 years of activity within the MONARCA EU project. The challenges listed and detailed in this paper may be used in future research as a starting point for identifying important non-functional requirements involved in mobile health provisioning...

  17. Expansion of the Kano model to identify relevant customer segments and functional requirements

    DEFF Research Database (Denmark)

    Atlason, Reynir Smari; Stefansson, Arnaldur Smari; Wietz, Miriam

    2017-01-01

    The Kano model of customer satisfaction has been widely used to analyse perceived needs of customers. The model provides product developers valuable information about if, and then how much a given functional requirement (FR) will impact customer satisfaction if implemented within a product, system...... or a service. A current limitation of the Kano model is that it does not allow developers to visualise which combined sets of FRs would provide the highest satisfaction between different customer segments. In this paper, a stepwise method to address this particular shortcoming is presented. First......, a traditional Kano analysis is conducted for the different segments of interest. Second, for each FR, relationship functions are integrated between x=0 and x=1. Third, integrals are inserted into a combination matrix crossing segments and FRs, where FRs with the highest sum across the chosen segments...

  18. Energy Data Visualization Requires Additional Approaches to Continue to be Relevant in a World with Greater Low-Carbon Generation

    International Nuclear Information System (INIS)

    Grant Wilson, I. A.

    2016-01-01

    The hypothesis described in this article proposes that energy visualization diagrams commonly used need additional changes to continue to be relevant in a world with greater low-carbon generation. The diagrams that display national energy data are influenced by the properties of the type of energy being displayed, which in most cases has historically meant fossil fuels, nuclear fuels, or hydro. As many energy systems throughout the world increase their use of electricity from wind- or solar-based renewables, a more granular display of energy data in the time domain is required. This article also introduces the shared axes energy diagram that provides a simple and powerful way to compare the scale and seasonality of the demands and supplies of an energy system. This aims to complement, rather than replace existing diagrams, and has an additional benefit of promoting a whole systems approach to energy systems, as differing energy vectors, such as natural gas, transport fuels, and electricity, can all be displayed together. This, in particular, is useful to both policy makers and to industry, to build a visual foundation for a whole systems narrative, which provides a basis for discussion of the synergies and opportunities across and between different energy vectors and demands. The diagram’s ability to wrap a sense of scale around a whole energy system in a simple way is thought to explain its growing popularity.

  19. Energy data visualisation requires additional approaches to continue to be relevant in a world with greater low-carbon generation.

    Directory of Open Access Journals (Sweden)

    I.A. Grant Wilson

    2016-08-01

    Full Text Available The hypothesis described in this article proposes that energy visualisation diagrams commonly used need additional changes to continue to be relevant in a world with greater low-carbon generation. The diagrams that display national energy data are influenced by the properties of the type of energy being displayed, which in most cases has historically meant fossil fuels, nuclear fuels or hydro. As many energy systems throughout the world increase their use of electricity from wind or solar based renewables, a more granular display of energy data in the time domain is required. This article also introduces the shared axes energy diagram that provides a simple and powerful way in which to compare the scale and seasonality of the demands and supplies of an energy system. This aims to complement rather than replace existing diagrams, and has an additional benefit of promoting a whole systems approach to energy systems, as differing energy vectors such as natural gas, transport fuels, and electricity can all be displayed together. This in particular, is useful to both policy makers and to industry, to build a visual foundation for a whole systems narrative, which provides a basis for discussion of the synergies and opportunities across and between different energy vectors and demands. The diagram’s ability to wrap a sense of scale around a whole energy system in a simple way is thought to explain its growing popularity.

  20. Energy Data Visualization Requires Additional Approaches to Continue to be Relevant in a World with Greater Low-Carbon Generation

    Energy Technology Data Exchange (ETDEWEB)

    Grant Wilson, I. A., E-mail: grant.wilson@sheffield.ac.uk [Environmental and Energy Engineering Group, Department of Chemical and Biological Engineering, The University of Sheffield, Sheffield (United Kingdom)

    2016-08-31

    The hypothesis described in this article proposes that energy visualization diagrams commonly used need additional changes to continue to be relevant in a world with greater low-carbon generation. The diagrams that display national energy data are influenced by the properties of the type of energy being displayed, which in most cases has historically meant fossil fuels, nuclear fuels, or hydro. As many energy systems throughout the world increase their use of electricity from wind- or solar-based renewables, a more granular display of energy data in the time domain is required. This article also introduces the shared axes energy diagram that provides a simple and powerful way to compare the scale and seasonality of the demands and supplies of an energy system. This aims to complement, rather than replace existing diagrams, and has an additional benefit of promoting a whole systems approach to energy systems, as differing energy vectors, such as natural gas, transport fuels, and electricity, can all be displayed together. This, in particular, is useful to both policy makers and to industry, to build a visual foundation for a whole systems narrative, which provides a basis for discussion of the synergies and opportunities across and between different energy vectors and demands. The diagram’s ability to wrap a sense of scale around a whole energy system in a simple way is thought to explain its growing popularity.

  1. 17 CFR 249.325 - Form 13F, report of institutional investment manager pursuant to section 13(f) of the Securities...

    Science.gov (United States)

    2010-04-01

    ... institutional investment manager pursuant to section 13(f) of the Securities Exchange Act of 1934. 249.325... manager pursuant to section 13(f) of the Securities Exchange Act of 1934. This form shall be used by institutional investment managers which are required to furnish reports pursuant to section 13(f) of the...

  2. Perioperative Temperature Measurement Considerations Relevant to Reporting Requirements for National Quality Programs Using Data From Anesthesia Information Management Systems.

    Science.gov (United States)

    Epstein, Richard H; Dexter, Franklin; Hofer, Ira S; Rodriguez, Luis I; Schwenk, Eric S; Maga, Joni M; Hindman, Bradley J

    2018-02-01

    Perioperative hypothermia may increase the incidences of wound infection, blood loss, transfusion, and cardiac morbidity. US national quality programs for perioperative normothermia specify the presence of at least 1 "body temperature" ≥35.5°C during the interval from 30 minutes before to 15 minutes after the anesthesia end time. Using data from 4 academic hospitals, we evaluated timing and measurement considerations relevant to the current requirements to guide hospitals wishing to report perioperative temperature measures using electronic data sources. Anesthesia information management system databases from 4 hospitals were queried to obtain intraoperative temperatures and intervals to the anesthesia end time from discontinuation of temperature monitoring, end of surgery, and extubation. Inclusion criteria included age >16 years, use of a tracheal tube or supraglottic airway, and case duration ≥60 minutes. The end-of-case temperature was determined as the maximum intraoperative temperature recorded within 30 minutes before the anesthesia end time (ie, the temperature that would be used for reporting purposes). The fractions of cases with intervals >30 minutes between the last intraoperative temperature and the anesthesia end time were determined. Among the hospitals, averages (binned by quarters) of 34.5% to 59.5% of cases had intraoperative temperature monitoring discontinued >30 minutes before the anesthesia end time. Even if temperature measurement had been continued until extubation, averages of 5.9% to 20.8% of cases would have exceeded the allowed 30-minute window. Averages of 8.9% to 21.3% of cases had end-of-case intraoperative temperatures <35.5°C (ie, a quality measure failure). Because of timing considerations, a substantial fraction of cases would have been ineligible to use the end-of-case intraoperative temperature for national quality program reporting. Thus, retrieval of postanesthesia care unit temperatures would have been necessary. A

  3. Report and recommendations of the Pingston Hydroelectric Project Committee with respect to the issuance of a project approval certificate pursuant to the Environmental Assessment Act, R.S.B.C. 1966, c.119 and fulfilling the requirements for a screening report pursuant to the Canadian Environmental Assessment Act, 1992 c.37, V.1

    International Nuclear Information System (INIS)

    1999-05-01

    A final application was submitted in March 1998 by Canadian Hydro Developers (CHD) with the intent of obtaining a Project Approval certificate under the Act for development of the Project. The purpose of the project committee report is to summarize the application and project report, to describe the potential environmental, economic, social, cultural, heritage and health effects of the project and measures required to mitigate significant adverse effects and to document the recommendations of the committee. The Project is composed of five main parts including the headworks, tunnel, penstock, powerhouse and transmission line. The potential environmental effects of the Project relate mainly to fisheries resources including entrainment at the intake, instream flow needs downstream from the headworks, alteration of fish habitat, sedimentation, and blockage of fish passage. CHD expects to minimize these effects through facility design modifications, operational changes and monitoring programs as required. Other concerns such as alteration of creek temperature, generation of methyl mercury in reservoirs, greenhouse gas flux in reservoirs and total gas pressures have been examined in light of the Project's size and operational schenarios, and the proponent expects these effects to be of minor concern. The Project Committee concluded that the project, with successful implementation and compliance of mitigation and compensation strategies, is not expected to cause significant adverse effects

  4. Cascade Heritage Power Project assessment and screening report[With respect to review of the application for an environmental assessment certificate pursuant to the British Columbia Environmental Assessement Act, SBC 2002, c. 43 and with respect to the requirements of a screening pursuant to the Canadian Environmental Assessment Act, SC 1992, c. 37 as amended

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-12

    In 1999, Powerhouse Development Inc. submitted an application to the British Columbia Environmental Assessment Office (EAO) for its proposed Cascade Heritage Power Project, a 25-megawatt run-of-the-river hydroelectric facility that consists of a weir, an intake structure, an underground tunnel, a power plant, a substation and a transmission line. The proposed site is on the Kettle River near Grand Forks, British Columbia in the unique recreational area of the Cascade Canyon and Falls. The project is also situated within Okanagan First Nations territory. In 2002, the proponent redesigned its application to address public concerns regarding the potential impacts on recreation and tourism, water availability, water quality, fish, land use and energy policy. The proponent agreed to continue consulting with local residents and community groups about the project. Okanagan Nation Alliance (ONA) consultation opportunities were provided by EAO during the assessment of the project. ONA issues of concern included potential adverse effects on water quantity and quality, fish, wildlife, vegetation, and archaeological sites, including a sacred spiritual site. The ONA were also concerned about restrictions on access to the area for traditional use. This paper summarized issues regarding the following potential project effects: the various elements of the redesigned project, intended to mitigate the potential adverse effects of the original proposal; the location of project components and how the project will operate; the potential environmental effects and proposed mitigation measures; and, the potential socio-economic effects and proposed mitigation measures. With reference to environmental effects, it was determined that fish habitat information requirements for the project have been addressed satisfactorily along with terrestrial biodiversity issues related to 11 wildlife species that are listed as endangered. Natural Resources Canada concluded that the proponent adequately

  5. Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements.

    Science.gov (United States)

    Walther, Barbara; Karl, J Philip; Booth, Sarah L; Boyaval, Patrick

    2013-07-01

    Vitamin K exists in the food supply as phylloquinone, a plant-based form and as menaquinones (MKs), a collection of isoprenologues mostly originating from bacterial synthesis. Although multiple bacterial species used as starter cultures for food fermentations synthesize MK, relatively little is known about the presence and distribution of MK in the food supply and the relative contribution of MK to total dietary vitamin K intake. Dairy products may be a predominant source of dietary MK in many regions of the world, and there is recent interest in enhancing the MK content of dairy products through identification and selection of MK-producing bacteria in dairy fermentations. This interest is increased by emerging evidence that current dietary recommendations based on the classic role of vitamin K as an enzyme cofactor for coagulation proteins may not be optimal for supporting vitamin K requirements in extrahepatic tissues and that MK may have unique bioactivity beyond that as an enzyme cofactor. Observational studies have reported favorable associations between MK intake and bone and cardiovascular health. Although randomized trials have provided some evidence to support the beneficial effects of MK on bone, the evidence to date is not definitive, and randomized trials have not yet examined MK intake in relation to cardiovascular outcomes. Food production practices provide a means to enhance dietary MK availability and intake. However, parallel research is needed to optimize these production practices, develop comprehensive food MK content databases, and test hypotheses of unique beneficial physiological roles of MK beyond that achieved by phylloquinone.

  6. Relevance of G8 scale in referring elderly patients with aortic stenosis requiring a TAVI for a geriatric consultation.

    Science.gov (United States)

    de Thézy, Albane; Lafargue, Aurélie; d'Arailh, Lydie; Dijos, Marina; Leroux, Lionel; Salles, Nathalie; Rainfray, Muriel

    2017-12-01

    Aortic stenosis (AS) may soon become a significant public health issue. Referring elderly suffering from aortic stenosis for a transcatheter aortic valve implantation (TAVI) versus surgical valve replacement might be difficult and requires a multidisciplinary staff. G8 is a geriatric screening scale for frailty, validated in oncogeriatry. We study sensibility and specificity of G8 used by cardiologists in comparison to a comprehensive geriatric assessment (CGA) performed by geriatrician. Prospective study, from February to July 2015, in Bordeaux university Hospital, France. Every elderly admitted for a TAVI had a G8 scale performed by cardiologist and CGA by a geriatrician in blind. Comorbidities were assessed using Cumulative Illness Rating Scale in his geriatric version (CIRS-G). CGA was abnormal if: MMSE value in comparison to gold-standard CGA. 49 patients were included (55.1% women, mean age 84.8 years old). Nearly half of the patients (48.96%) had multiple comorbidities (CIRS G score >3 for at least three items excluding the cardiology item). 38 CGA were abnormal (77.55%) and 41 G8 (83.67%). G8 had a sensibility of 100% (IC 95% [0.9-1]), a specificity of 72.7% (IC 95% [0.43-0.9]), a positive predictive value of 92.6% and a negative prospective value of 100% (IC: 95%). G8 scale seems to be an efficient geriatric screening tool for frailty in elderly undergoing TAVI in comparison to CGA. Simple and useful, G8 scale could be performed by cardiologists in older patients with AS for identifying patients with a geriatric risk profile in consultation before surgery. Further studies with bigger samples are needed to confirm these results.

  7. Toxicity assessment strategies, data requirements, and risk assessment approaches to derive health based guidance values for non-relevant metabolites of plant protection products.

    Science.gov (United States)

    Dekant, Wolfgang; Melching-Kollmuss, Stephanie; Kalberlah, Fritz

    2010-03-01

    In Europe, limits for tolerable concentrations of "non-relevant metabolites" for active ingredients (AI) of plant protection products in drinking water between 0.1 and 10 microg/L are discussed depending on the toxicological information available. "Non-relevant metabolites" are degradation products of AIs, which do not or only partially retain the targeted toxicities of AIs. For "non-relevant metabolites" without genotoxicity (to be confirmed by testing in vitro), the application of the concept of "thresholds of toxicological concern" results in a health-based drinking water limit of 4.5 microg/L even for Cramer class III compounds, using the TTC threshold of 90 microg/person/day (divided by 10 and 2). Taking into account the thresholds derived from two reproduction toxicity data bases a drinking water limit of 3.0 microg/L is proposed. Therefore, for "non-relevant metabolites" whose drinking water concentration is below 3.0 microg/L, no toxicity testing is necessary. This work develops a toxicity assessment strategy as a basis to delineate health-based limits for "non-relevant metabolites" in ground and drinking water. Toxicological testing is recommended to investigate, whether the metabolites are relevant or not, based on the hazard properties of the parent AIs, as outlined in the SANCO Guidance document. Also, genotoxicity testing of the water metabolites is clearly recommended. In this publication, tiered testing strategies are proposed for non-relevant metabolites, when drinking water concentrations >3.0 microg/L will occur. Conclusions based on structure-activity relationships and the detailed toxicity database on the parent AI should be included. When testing in animals is required for risk assessment, key aspects are studies along OECD-testing guidelines with "enhanced" study designs addressing additional endpoints such as reproductive toxicity and a developmental screening test to derive health-based tolerable drinking water limits with a limited number

  8. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Paducah Gaseous Diffusion Plant: A compendium of environmental laws and guidance

    International Nuclear Information System (INIS)

    Etnier, E.L.; Eaton, L.A.

    1992-03-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances found at sites placed on the National Priorities List (NPL) by the US Environmental Protection Agency (EPA) must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. To date, the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant (PGDP) has not been on the NPL. Although DOE and EPA have entered into an Administrative Consent Order (ACO), the prime regulatory authority for cleanup at PGDP will be the Resource Conservation and Recovery Act (RCRA). This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PGDP in the event that the plant becomes included on the NPL or the ACO is modified to include CERCLA cleanup. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Kentucky are listed in tables. In addition, the major provisions of RCRA, the Safe Drinking Water Act, the Clean Water Act, the Clean Air Act, and other acts, as they apply to hazardous and radioactive waste cleanup, are discussed

  9. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Portsmouth Gaseous Diffusion Plant: A compendium of environmental laws and guidance

    International Nuclear Information System (INIS)

    Houlberg, L.M.; Eaton, L.A.; Martin, J.A.; McDonald, E.P.; Etnier, E.L.

    1992-02-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act of 1990 (CERCLA) specifies that remedial actions for cleanup of hazardous substances must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. Although the US Department of Energy (DOE) Portsmouth Gaseous Diffusion Plant (PORTS) has not at this time been proposed for inclusion on the US Environmental Protection Agency National Priorities List, under Sect. I of an administrative consent order signed by DOE and the US Environmental Protection Agency on September 29, 1989, effective October 4, 1989, any necessary response actions at PORTS stipulated in the administrative consent order must be performed in a manner consistent with the Resource Conservation and Recovery Act of 1976 and CERCLA. Section 121 of CERCLA calls for the preparation of a draft listing of all ARARs. This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PORTS. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARs. ARARs promulgated by the federal government and by the state of Ohio are listed in tables. In addition, the major provisions of the Resource Conservation and Recovery Act, Safe Drinking Water Act, Clean Water Act, and other acts, as they apply to hazardous waste cleanup, are discussed

  10. Applicable or Relevant and Appropriate Requirements (ARARs) for Remedial Action at the Oak Ridge Reservation: A compendium of major environmental laws

    International Nuclear Information System (INIS)

    Etnier, E.L.; McDonald, E.P.; Houlberg, L.M.

    1993-07-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances must comply with applicable or relevant and appropriate requirements (ARARS) or standards under federal and state environmental laws. The US Department of Energy (DOE) Oak Ridge Reservation (ORR) was placed on the National Priorities List by the US Environmental Protection Agency (EPA) on November 21, 1989, effective December 21, 1989. As a result of this listing, DOE, EPA, and the Tennessee Department of Environment and Conservation have signed a Federal Facility Agreement (FFA) for the environmental restoration of the ORR. Section XXI(F) of the FFA calls for the preparation of a draft listing of all ARARs as mandated by CERCLA section 121. This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at the ORR. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Tennessee are listed in tables. In addition, the major provisions of the Resource Conservation and Recovery Act, the Safe Drinking Water Act, the Clean Water Act, the Clean Air and other acts, as they apply to hazardous waste cleanup, are discussed. In the absence of ARARS, CERCLA section 121 provides for the use of nonpromulgated federal criteria, guidelines, and advisories in evaluating the human risk associated with remedial action alternatives. Such nonpromulgated standards are classified as ''to-be-considered'' (TBC) guidance. A ion of available guidance is given; summary tables fist the available federal standards and guidance information. In addition, the substantive contents of the DOE orders as they apply to remediation of radioactively contaminated sites are discussed as TBC guidance

  11. Applicable or Relevant and Appropriate Requirements (ARARs) for Remedial Action at the Oak Ridge Reservation: A compendium of major environmental laws. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Etnier, E.L.; McDonald, E.P.; Houlberg, L.M.

    1993-07-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances must comply with applicable or relevant and appropriate requirements (ARARS) or standards under federal and state environmental laws. The US Department of Energy (DOE) Oak Ridge Reservation (ORR) was placed on the National Priorities List by the US Environmental Protection Agency (EPA) on November 21, 1989, effective December 21, 1989. As a result of this listing, DOE, EPA, and the Tennessee Department of Environment and Conservation have signed a Federal Facility Agreement (FFA) for the environmental restoration of the ORR. Section XXI(F) of the FFA calls for the preparation of a draft listing of all ARARs as mandated by CERCLA {section}121. This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at the ORR. A description of the terms ``applicable`` and ``relevant and appropriate`` is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Tennessee are listed in tables. In addition, the major provisions of the Resource Conservation and Recovery Act, the Safe Drinking Water Act, the Clean Water Act, the Clean Air and other acts, as they apply to hazardous waste cleanup, are discussed. In the absence of ARARS, CERCLA {section}121 provides for the use of nonpromulgated federal criteria, guidelines, and advisories in evaluating the human risk associated with remedial action alternatives. Such nonpromulgated standards are classified as ``to-be-considered`` (TBC) guidance. A ion of available guidance is given; summary tables fist the available federal standards and guidance information. In addition, the substantive contents of the DOE orders as they apply to remediation of radioactively contaminated sites are discussed as TBC guidance.

  12. Nuclear deterrence, which relevance in the 21. century? To debate on deterrence: a democratic requirement, a strategic necessity. Nuclear deterrence: relevance or obsolescence? The Catholic Church and the nuclear deterrence

    International Nuclear Information System (INIS)

    Dupuy, Emmanuel; Fath, Jacques; Le Dauphin, Jacques

    2015-09-01

    In a first article, a member of a centrist party in charge of defence issues calls for a broader debate on nuclear weapons, and notably questions the existence of the airborne component of the French deterrence (as the ground-based component has already been suppressed), and more particularly when budgets and their evolutions are taken into account. He states that the principles of nuclear deterrence can be met with only the sea-borne component. He also outlines the role a European Defence should have. He discusses a possible approach to disarmament. In the second article, the author discusses the past acceptable relevance and present obsolescence of the nuclear weapon. The last article proposes an overview of opinions expressed by the Catholic Church since the 1950's about nuclear weapons and nuclear deterrence, and always more in favour of a nuclear disarmament

  13. Tangible fixed assets of a company pursuant to the czech accounting law and international accounting standards

    OpenAIRE

    Patrik Svoboda; Emil Svoboda

    2007-01-01

    The valuation of assets is a challenging activity as well as a scientific discipline having an impact on the amount of the reported assets and economic result process. The report deals with the issue of valuation of the tangible fixed assets in the accounting entities compiling the financial statements pursuant to the Czech national legislation and in conformity with the requirements of the International Accounting Standards IAS/IFRS and US GAAP. The substantial differences in the definitions...

  14. 5 CFR 2640.302 - Waivers issued pursuant to 18 U.S.C. 208(b)(3).

    Science.gov (United States)

    2010-01-01

    ... actual or potential profit or loss or cost of the matter to the company issuing the stock, the change in...) Requirements for issuing an individual waiver under 18 U.S.C. 208(b)(3). Pursuant to 18 U.S.C. 208(b)(3), an...) The type of interest that is creating the disqualification (e.g. stock, bonds, real estate, other...

  15. European Legislation to Prevent Loss of Control of Sources and to Recover Orphan Sources, and Other Requirements Relevant to the Scrap Metal Industry

    Energy Technology Data Exchange (ETDEWEB)

    Janssens, A.; Tanner, V.; Mundigl, S., E-mail: augustin.janssens@ec.europa.eu [European Commission (Luxembourg)

    2011-07-15

    European legislation (Council Directive 2003/122/EURATOM) has been adopted with regard to the control of high-activity sealed radioactive sources (HASS). This Directive is now part of an overall recast of current radiation protection legislation. At the same time the main Directive, 96/29/EURATOM, laying down Basic Safety Standards (BSS) for the health protection of the general public and workers against the dangers of ionizing radiation, is being revised in the light of the new recommendations of the International Commission on Radiological Protection (ICRP). The provisions for exemption and clearance are a further relevant feature of the new BSS. The current issues emerging from the revision and recast of the BSS are discussed, in the framework of the need to protect the scrap metal industry from orphan sources and to manage contaminated metal products. (author)

  16. User perspectives on relevance criteria

    DEFF Research Database (Denmark)

    Maglaughlin, Kelly L.; Sonnenwald, Diane H.

    2002-01-01

    , partially relevant, or not relevant to their information need; and explained their decisions in an interview. Analysis revealed 29 criteria, discussed positively and negatively, that were used by the participants when selecting passages that contributed or detracted from a document's relevance......This study investigates the use of criteria to assess relevant, partially relevant, and not-relevant documents. Study participants identified passages within 20 document representations that they used to make relevance judgments; judged each document representation as a whole to be relevant...... matter, thought catalyst), full text (e.g., audience, novelty, type, possible content, utility), journal/publisher (e.g., novelty, main focus, perceived quality), and personal (e.g., competition, time requirements). Results further indicate that multiple criteria are used when making relevant, partially...

  17. A Safety and Health Guide for Vocational Educators. Incorporating Requirements of the Occupational Safety and Health Act of 1970, Relevant Pennsylvania Requirements with Particular Emphasis for Those Concerned with Cooperative Education and Work Study Programs. Volume 15. Number 1.

    Science.gov (United States)

    Wahl, Ray

    Intended as a guide for vocational educators to incorporate the requirements of the Occupational Safety and Health Act (1970) and the requirements of various Pennsylvania safety and health regulations with their cooperative vocational programs, the first chapter of this document presents the legal implications of these safety and health…

  18. 49 CFR 577.6 - Notification pursuant to Administrator's decision.

    Science.gov (United States)

    2010-10-01

    ... making his decision. (6) A clear description of the Administrator' stated evaluation as provided in his..., of the purchase price; and (C) A statement that, if the Court upholds the Administrator's decision... 49 Transportation 7 2010-10-01 2010-10-01 false Notification pursuant to Administrator's decision...

  19. 46 CFR 147.8 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-10-01

    ...) DANGEROUS CARGOES HAZARDOUS SHIPS' STORES General Provisions § 147.8 OMB control numbers assigned pursuant... Management and Budget (OMB) pursuant to the Paperwork Reduction Act of 1980 (44 U.S.C. 3501 et seq.). The...

  20. The Limits to Relevance

    Science.gov (United States)

    Averill, M.; Briggle, A.

    2006-12-01

    Science policy and knowledge production lately have taken a pragmatic turn. Funding agencies increasingly are requiring scientists to explain the relevance of their work to society. This stems in part from mounting critiques of the "linear model" of knowledge production in which scientists operating according to their own interests or disciplinary standards are presumed to automatically produce knowledge that is of relevance outside of their narrow communities. Many contend that funded scientific research should be linked more directly to societal goals, which implies a shift in the kind of research that will be funded. While both authors support the concept of useful science, we question the exact meaning of "relevance" and the wisdom of allowing it to control research agendas. We hope to contribute to the conversation by thinking more critically about the meaning and limits of the term "relevance" and the trade-offs implicit in a narrow utilitarian approach. The paper will consider which interests tend to be privileged by an emphasis on relevance and address issues such as whose goals ought to be pursued and why, and who gets to decide. We will consider how relevance, narrowly construed, may actually limit the ultimate utility of scientific research. The paper also will reflect on the worthiness of research goals themselves and their relationship to a broader view of what it means to be human and to live in society. Just as there is more to being human than the pragmatic demands of daily life, there is more at issue with knowledge production than finding the most efficient ways to satisfy consumer preferences or fix near-term policy problems. We will conclude by calling for a balanced approach to funding research that addresses society's most pressing needs but also supports innovative research with less immediately apparent application.

  1. Why relevance theory is relevant for lexicography

    DEFF Research Database (Denmark)

    Bothma, Theo; Tarp, Sven

    2014-01-01

    This article starts by providing a brief summary of relevance theory in information science in relation to the function theory of lexicography, explaining the different types of relevance, viz. objective system relevance and the subjective types of relevance, i.e. topical, cognitive, situational...... that is very important for lexicography as well as for information science, viz. functional relevance. Since all lexicographic work is ultimately aimed at satisfying users’ information needs, the article then discusses why the lexicographer should take note of all these types of relevance when planning a new...... dictionary project, identifying new tasks and responsibilities of the modern lexicographer. The article furthermore discusses how relevance theory impacts on teaching dictionary culture and reference skills. By integrating insights from lexicography and information science, the article contributes to new...

  2. Deep learning relevance

    DEFF Research Database (Denmark)

    Lioma, Christina; Larsen, Birger; Petersen, Casper

    2016-01-01

    train a Recurrent Neural Network (RNN) on existing relevant information to that query. We then use the RNN to "deep learn" a single, synthetic, and we assume, relevant document for that query. We design a crowdsourcing experiment to assess how relevant the "deep learned" document is, compared...... to existing relevant documents. Users are shown a query and four wordclouds (of three existing relevant documents and our deep learned synthetic document). The synthetic document is ranked on average most relevant of all....

  3. 5 CFR 297.402 - Disclosure pursuant to a compulsory legal process served on the Office.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Disclosure pursuant to a compulsory legal process served on the Office. 297.402 Section 297.402 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PRIVACY PROCEDURES FOR PERSONNEL RECORDS Disclosure of Records § 297.402 Disclosure pursuant to a compulsory...

  4. 75 FR 1492 - Commission Guidance Regarding Independent Public Accountant Engagements Performed Pursuant to...

    Science.gov (United States)

    2010-01-11

    ... Guidance Regarding Independent Public Accountant Engagements Performed Pursuant to Rule 206(4)-2 Under the... independent public accountants in connection with the adoption of amendments to Rule 206(4)-2 under the... least once during each calendar year by an independent public accountant \\1\\ (``accountant''), pursuant...

  5. 78 FR 23827 - Designation of Eighteen Individuals Pursuant to the Sergei Magnitsky Rule of Law Accountability...

    Science.gov (United States)

    2013-04-22

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of Eighteen Individuals Pursuant to the Sergei Magnitsky Rule of Law Accountability Act of 2012 AGENCY: Office of Foreign Assets... blocked pursuant to the Sergei Magnitsky Rule of Law Accountability Act of 2012 (Pub. L. 112-208, December...

  6. 78 FR 64248 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Heterogeneous...

    Science.gov (United States)

    2013-10-28

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and...; Synopsys Inc., Mountain View, CA; and Kishonti Kft (individual member), Budapest, HUNGARY, have been added... the Act. The Department of Justice published a notice in the Federal Register pursuant to Section 6(b...

  7. 78 FR 56939 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Opendaylight...

    Science.gov (United States)

    2013-09-16

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and.... In addition, Big Switch Networks, Mountain View, CA has withdrawn as a party to this venture. No... notification pursuant to Section 6(a) of the Act. The Department of Justice published a notice in the Federal...

  8. 78 FR 7455 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Heterogeneous...

    Science.gov (United States)

    2013-02-01

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... Tsing Hua University, Hsinchu, Taiwan, PEOPLE'S REPUBLIC OF CHINA; Ceva Inc., Mountain View, CA... the Act. The Department of Justice published a notice in the Federal Register pursuant to Section 6(b...

  9. Analytical Performance Requirements for Systems for Self-Monitoring of Blood Glucose With Focus on System Accuracy: Relevant Differences Among ISO 15197:2003, ISO 15197:2013, and Current FDA Recommendations.

    Science.gov (United States)

    Freckmann, Guido; Schmid, Christina; Baumstark, Annette; Rutschmann, Malte; Haug, Cornelia; Heinemann, Lutz

    2015-07-01

    In the European Union (EU), the ISO (International Organization for Standardization) 15197 standard is applicable for the evaluation of systems for self-monitoring of blood glucose (SMBG) before the market approval. In 2013, a revised version of this standard was published. Relevant revisions in the analytical performance requirements are the inclusion of the evaluation of influence quantities, for example, hematocrit, and some changes in the testing procedures for measurement precision and system accuracy evaluation, for example, number of test strip lots. Regarding system accuracy evaluation, the most important change is the inclusion of more stringent accuracy criteria. In 2014, the Food and Drug Administration (FDA) in the United States published their own guidance document for the premarket evaluation of SMBG systems with even more stringent system accuracy criteria than stipulated by ISO 15197:2013. The establishment of strict accuracy criteria applicable for the premarket evaluation is a possible approach to further improve the measurement quality of SMBG systems. However, the system accuracy testing procedure is quite complex, and some critical aspects, for example, systematic measurement difference between the reference measurement procedure and a higher-order procedure, may potentially limit the apparent accuracy of a given system. Therefore, the implementation of a harmonized reference measurement procedure for which traceability to standards of higher order is verified through an unbroken, documented chain of calibrations is desirable. In addition, the establishment of regular and standardized post-marketing evaluations of distributed test strip lots should be considered as an approach toward an improved measurement quality of available SMBG systems. © 2015 Diabetes Technology Society.

  10. 77 FR 39320 - Suggestions for Environmental Cooperation Pursuant to the United States-Singapore Memorandum of...

    Science.gov (United States)

    2012-07-02

    ... friendly environmental technology and pollution management techniques; (2) participating in regional... DEPARTMENT OF STATE [Public Notice 7943] Suggestions for Environmental Cooperation Pursuant to the United States-Singapore Memorandum of Intent on Environmental Cooperation AGENCY: Department of State...

  11. 75 FR 27743 - Publication of State Plan Pursuant to the Help America Vote Act

    Science.gov (United States)

    2010-05-18

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act... previously submitted by New Mexico. DATES: This notice is effective upon publication in the Federal Register... 27744

  12. 17 CFR 201.550 - Summary suspensions pursuant to Exchange Act Section 12(k)(1)(A).

    Science.gov (United States)

    2010-04-01

    ... termination of suspension. Any person adversely affected by a suspension pursuant to Section 12(k)(1)(A) of... the public interest or for the protection of investors may file a sworn petition with the Secretary...

  13. 77 FR 34121 - Designation and Determination Pursuant to the Foreign Missions Act Concerning the Designation of...

    Science.gov (United States)

    2012-06-08

    ..., 1994, I hereby designate the State Oil Company of the Republic of Azerbaijan (SOCAR), an entity engaged... apply to the acquisition or disposition of real property by or on behalf of such entities. Pursuant to...

  14. 17 CFR 249.821 - Form PILOT, information required of self-regulatory organizations operating pilot trading systems...

    Science.gov (United States)

    2010-04-01

    ... required of self-regulatory organizations operating pilot trading systems pursuant to § 240.19b-5 of this... Associations § 249.821 Form PILOT, information required of self-regulatory organizations operating pilot trading systems pursuant to § 240.19b-5 of this chapter. This form shall be used by all self-regulatory...

  15. Making Deferred Taxes Relevant

    NARCIS (Netherlands)

    Brouwer, Arjan; Naarding, Ewout

    2018-01-01

    We analyse the conceptual problems in current accounting for deferred taxes and provide solutions derived from the literature in order to make International Financial Reporting Standards (IFRS) deferred tax numbers value-relevant. In our view, the empirical results concerning the value relevance of

  16. Parsimonious relevance models

    NARCIS (Netherlands)

    Meij, E.; Weerkamp, W.; Balog, K.; de Rijke, M.; Myang, S.-H.; Oard, D.W.; Sebastiani, F.; Chua, T.-S.; Leong, M.-K.

    2008-01-01

    We describe a method for applying parsimonious language models to re-estimate the term probabilities assigned by relevance models. We apply our method to six topic sets from test collections in five different genres. Our parsimonious relevance models (i) improve retrieval effectiveness in terms of

  17. Safety of betaine as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on betaine as a novel food (NF) pursuant to Regulation (EC) No 258/97. The information provided on the composition, the specifications, the batch......-to-batch variability, stability and production process of the NF is sufficient and does not raise concerns about the safety of the NF. The NF is proposed to be used in foods intended to meet additional requirements for intense muscular effort with a maximum intake of 2.5 g/day of betaine for sports people above 10...... as not sufficient. However, the total exposure to betaine from the diet (about 830 mg/day) is not known to be associated with adverse effects. Moreover, no adverse effects on platelet counts were noted in human intervention studies with exposure levels of 4 g/day of betaine for up to 6 months. A significant...

  18. Culturally Relevant Cyberbullying Prevention

    OpenAIRE

    Phillips, Gregory John

    2017-01-01

    In this action research study, I, along with a student intervention committee of 14 members, developed a cyberbullying intervention for a large urban high school on the west coast. This high school contained a predominantly African American student population. I aimed to discover culturally relevant cyberbullying prevention strategies for African American students. The intervention committee selected video safety messages featuring African American actors as the most culturally relevant cyber...

  19. Relevant Subspace Clustering

    DEFF Research Database (Denmark)

    Müller, Emmanuel; Assent, Ira; Günnemann, Stephan

    2009-01-01

    Subspace clustering aims at detecting clusters in any subspace projection of a high dimensional space. As the number of possible subspace projections is exponential in the number of dimensions, the result is often tremendously large. Recent approaches fail to reduce results to relevant subspace...... clusters. Their results are typically highly redundant, i.e. many clusters are detected multiple times in several projections. In this work, we propose a novel model for relevant subspace clustering (RESCU). We present a global optimization which detects the most interesting non-redundant subspace clusters...... achieves top clustering quality while competing approaches show greatly varying performance....

  20. Is Information Still Relevant?

    Science.gov (United States)

    Ma, Lia

    2013-01-01

    Introduction: The term "information" in information science does not share the characteristics of those of a nomenclature: it does not bear a generally accepted definition and it does not serve as the bases and assumptions for research studies. As the data deluge has arrived, is the concept of information still relevant for information…

  1. Clinical Relevance of Adipokines

    Directory of Open Access Journals (Sweden)

    Matthias Blüher

    2012-10-01

    Full Text Available The incidence of obesity has increased dramatically during recent decades. Obesity increases the risk for metabolic and cardiovascular diseases and may therefore contribute to premature death. With increasing fat mass, secretion of adipose tissue derived bioactive molecules (adipokines changes towards a pro-inflammatory, diabetogenic and atherogenic pattern. Adipokines are involved in the regulation of appetite and satiety, energy expenditure, activity, endothelial function, hemostasis, blood pressure, insulin sensitivity, energy metabolism in insulin sensitive tissues, adipogenesis, fat distribution and insulin secretion in pancreatic β-cells. Therefore, adipokines are clinically relevant as biomarkers for fat distribution, adipose tissue function, liver fat content, insulin sensitivity, chronic inflammation and have the potential for future pharmacological treatment strategies for obesity and its related diseases. This review focuses on the clinical relevance of selected adipokines as markers or predictors of obesity related diseases and as potential therapeutic tools or targets in metabolic and cardiovascular diseases.

  2. Information Needs/Relevance

    OpenAIRE

    Wildemuth, Barbara M.

    2009-01-01

    A user's interaction with a DL is often initiated as the result of the user experiencing an information need of some kind. Aspects of that experience and how it might affect the user's interactions with the DL are discussed in this module. In addition, users continuously make decisions about and evaluations of the materials retrieved from a DL, relative to their information needs. Relevance judgments, and their relationship to the user's information needs, are discussed in this module. Draft

  3. Relevance in print of law of administrative regulations according to paragraph 48 BImSchG in the licensing procedure

    International Nuclear Information System (INIS)

    Breuer, R.

    1978-01-01

    The author discusses in great detail the legal problem of administrative regulations according to paragraph 48 of the Bundes-Immissionsschutzgesetz, BImSchG (Federal Act for the prevention of immissions) and their relevance in point of law in licensing procedures. He very carefully and skilfully presents the different opinions stated in the precedents and by the body of doctrine and quite convincingly explains why he rejects the doctrine of allowing the administration some latitude in their judgement, and thus the doctrine of the defensible opinion with regard to the examination by the court of undefined legal terms. According to the auther's view, the administrative regulations should be regarded as anticipated expert opinions because of the way they are drawn up and because of the way the relevant committees setting up the rules are constituted, i.e. they can serve as a basis for judical decisions. In this connection the author points out that in any case it is left to the court's decisions whether a non-formal expert opinion is deemed to be sufficient, or whether the rules of procedure require a formal expert opinion. Furthermore, several ways of enhancing the binding effect of the administrative regulations pursuant to paragraph 48 of the BImSchG by means of legislatory measures are shown. (UN) [de

  4. 75 FR 29487 - Reports, Forms and Record Keeping Requirements, Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2010-05-26

    ... employees thereof, who respond or have a duty to respond to an information provision requirement pursuant to... likely to be a substantial motivating force for a submission of a proper report. We estimate that no more...

  5. 78 FR 23330 - Reports, Forms and Record Keeping Requirements, Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2013-04-18

    ... employees thereof, who respond or have a duty to respond to an information provision requirement pursuant to... likely to be a substantial motivating force for a submission of a proper report. We estimate that no more...

  6. 75 FR 57502 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Robotics...

    Science.gov (United States)

    2010-09-21

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Robotics Technology Consortium, Inc. Correction In notice document 2010-22215 beginning on page 54914 in the issue of Thursday, July 9, 2010, make the following corrections: 1. On page...

  7. 75 FR 35125 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to the Foreign...

    Science.gov (United States)

    2010-06-21

    ... California CP 22000, Mexico; Calle Granito No. 2025, Seccion El Dorado, Fraccionamiento Playas de Tijuana, Tijuana, Baja California, Mexico; Calle Granito No. 602, Seccion El Dorado, Fraccionamiento Playas de... blocked pursuant to the Kingpin Act. 1. Carrillo Rodriguez, Luis Miguel, c/o VUELA PERU S.A.C., Lima, Peru...

  8. 76 FR 6497 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Industrial...

    Science.gov (United States)

    2011-02-04

    ..., 15 U.S.C. 4301 et seq. (``the Act''), Industrial Nacromolecular Crystallography Association (``INCA... activity of the group research project. Membership in this group research project remains open, and INCA..., INCA filed its original notification pursuant to Section 6(a) of the Act. The Department of Justice...

  9. 77 FR 68828 - Certain Cases for Portable Electronic Devices; Institution of Investigation Pursuant to the...

    Science.gov (United States)

    2012-11-16

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-861] Certain Cases for Portable Electronic Devices; Institution of Investigation Pursuant to the Tariff Act of 1930, as Amended AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice is hereby given that a complaint was filed with...

  10. 77 FR 20847 - Certain Mobile Electronic Devices Incorporating Haptics; Institution of Investigation Pursuant to...

    Science.gov (United States)

    2012-04-06

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-834] Certain Mobile Electronic Devices Incorporating Haptics; Institution of Investigation Pursuant to 19 U.S.C. 1337 AGENCY: U.S. International Trade.... International Trade Commission on February 7, 2012, and an amended complaint was filed with the U.S...

  11. 77 FR 75425 - Publication of State Plan Pursuant to the Help America Vote Act

    Science.gov (United States)

    2012-12-20

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act... site at www.eac.gov . DATES: This notice is effective upon publication in the Federal Register. FOR... with HAVA Section 254(a)(12), all the State plans submitted for publication provide information on how...

  12. 75 FR 6643 - Publication of State Plan Pursuant to the Help America Vote Act

    Science.gov (United States)

    2010-02-10

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act... plans previously submitted by New Jersey and Wisconsin. DATES: This notice is effective upon publication... the State plans submitted for publication provide information on how the respective State succeeded in...

  13. 75 FR 41454 - Publication of State Plan Pursuant to the Help America Vote Act

    Science.gov (United States)

    2010-07-16

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act... plans previously submitted by Alaska. DATES: This notice is effective upon publication in the Federal... programs. In accordance with HAVA Section 254(a)(12), all the state plans submitted for publication provide...

  14. 75 FR 51759 - Publication of State Plan Pursuant to the Help America Vote Act

    Science.gov (United States)

    2010-08-23

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act... previously submitted by California. DATES: This notice is effective upon publication in the Federal Register... plans submitted for publication provide information on how the respective state succeeded in carrying...

  15. 78 FR 77110 - Publication of State Plan Pursuant to the Help America Vote Act

    Science.gov (United States)

    2013-12-20

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act... at www.eac.gov . DATES: This notice is effective upon publication in the Federal Register. FOR... publication provide information on how the respective State succeeded in carrying out its previous State plan...

  16. 75 FR 39671 - Publication of State Plan Pursuant to the Help America Vote Act

    Science.gov (United States)

    2010-07-12

    ... ELECTION ASSISTANCE COMMISSION Publication of State Plan Pursuant to the Help America Vote Act... plan previously submitted by South Dakota. DATES: This notice is effective upon publication in the... 254(a)(12), all the state plans submitted for publication provide information on how the respective...

  17. 78 FR 28701 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

    Science.gov (United States)

    2013-05-15

    ... property and interests in property were blocked pursuant to the Order: 1. ARBOLEDA ARROYAVE, Pedro Nicholas (a.k.a. ARBOLEDA ARROYAVE, Pedro Nicolas), c/o DEPOSITO POPULAR DE DROGAS S.A., Cali, Colombia; c/ o...., Bogota, Colombia; Cedula No. 11352426 (Colombia) (individual) [SDNT]. 4. DUQUE MARTINEZ, Diego Fernando...

  18. 29 CFR 71.52 - Specific exemptions pursuant to subsection (k)(5) of the Privacy Act.

    Science.gov (United States)

    2010-07-01

    ... (Investigative Case Tracking Systems/Audit Information Reporting Systems, USDOL/OIG), a system of records... AND ACCESS TO RECORDS UNDER THE PRIVACY ACT OF 1974 Exemption of Records Systems Under the Privacy Act § 71.52 Specific exemptions pursuant to subsection (k)(5) of the Privacy Act. (a) The following systems...

  19. 29 CFR 71.51 - Specific exemptions pursuant to subsection (k)(2) of the Privacy Act.

    Science.gov (United States)

    2010-07-01

    ... (Investigative Case Tracking Systems/Audit Information Reporting Systems, USDOL/OIG), a system of records... AND ACCESS TO RECORDS UNDER THE PRIVACY ACT OF 1974 Exemption of Records Systems Under the Privacy Act § 71.51 Specific exemptions pursuant to subsection (k)(2) of the Privacy Act. (a) The following systems...

  20. 29 CFR 71.50 - General exemptions pursuant to subsection (j) of the Privacy Act.

    Science.gov (United States)

    2010-07-01

    ... (Investigative Case Tracking Systems/Audit Information Reporting Systems, USDOL/OIG), a system of records... ACCESS TO RECORDS UNDER THE PRIVACY ACT OF 1974 Exemption of Records Systems Under the Privacy Act § 71.50 General exemptions pursuant to subsection (j) of the Privacy Act. (a) The following systems of...

  1. 78 FR 13140 - Additional Designation of Amr Armanazi Pursuant to Executive Order 13382

    Science.gov (United States)

    2013-02-26

    ..., inter alia, of the International Emergency Economic Powers Act (50 U.S.C. 1701-1706) (``IEEPA''), issued... manufacture, acquire, possess, develop, transport, transfer or use such items, by any person or foreign... Control and International Security of the entity identified in this notice pursuant to Executive Order...

  2. 78 FR 35646 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

    Science.gov (United States)

    2013-06-13

    ... Production Act of 1993--ASTM International Standards Notice is hereby given that, on May 10, 2013, pursuant... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

  3. 77 FR 34069 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

    Science.gov (United States)

    2012-06-08

    ... Production Act of 1993--ASTM International Standards Notice is hereby given that, on May 11, 2012, pursuant... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

  4. 76 FR 34252 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; ASTM...

    Science.gov (United States)

    2011-06-13

    ... Production Act of 1993; ASTM International Standards Notice is hereby given that, on May 11, 2011, pursuant... seq. (``the Act''), ASTM International Standards (``ASTM'') has filed written notifications.... Specifically, ASTM has provided an updated list of current, ongoing ASTM standards activities originating...

  5. 7 CFR 54.1034 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS..., Processing, and Packaging of Livestock and Poultry Products § 54.1034 OMB control numbers assigned pursuant...

  6. 75 FR 13781 - Notice of Lodging of Consent Decree Pursuant to the Clean Water Act

    Science.gov (United States)

    2010-03-23

    ... Operating Partnership LP, Civ. A. No. 10-106, was lodged with the United States Court for the District of... Act, 33 U.S.C. 1321, against Defendant NuStar Pipeline Operating Partnership LP. The Complaint alleges that Defendant failed to comply with regulations issued pursuant to Section 311(j)(5) of the CWA, 33 U...

  7. 75 FR 24971 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Intellegere...

    Science.gov (United States)

    2010-05-06

    ... Production Act of 1993--Intellegere Foundation Notice is hereby given that, on April 7, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq...) to facilitate scientific collaboration by addressing challenges of national security; (b) to promote...

  8. 76 FR 9812 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Halon...

    Science.gov (United States)

    2011-02-22

    ... Production Act of 1993--Halon Alternatives Research Corporation, Inc. Notice is hereby given that, on January 18, 2011, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act''), Halon Alternatives Research Corporation, Inc. (``HARC'') has...

  9. 78 FR 23332 - Supplemental Identification Information for Two (2) Individuals Designated Pursuant to Executive...

    Science.gov (United States)

    2013-04-18

    ... two (2) individuals in this notice, pursuant is effective on April 11, 2013. FOR FURTHER INFORMATION... determined by the Secretary of State, in consultation with the Secretary of the Treasury, the Secretary of..., in consultation with the Departments of State, Homeland [[Page 23333

  10. 75 FR 17822 - Designation and Determination Pursuant to the Foreign Missions Act

    Science.gov (United States)

    2010-04-07

    ... Vietnam Trade Promotion Center, as well as any other entity in the United States which is substantially... protect the interests of the United States in that context, pursuant to the authority vested in me by the... Authority No. 214, Section 14, dated September 20, 1994, I hereby designate the Vietnam News Agency, an...

  11. 75 FR 27855 - Certifications Pursuant to Section 609 of Public Law 101-162

    Science.gov (United States)

    2010-05-18

    ... DEPARTMENT OF STATE [Public Notice 7013] Certifications Pursuant to Section 609 of Public Law 101... Law 101-162 (``Section 609''), that 13 nations have adopted programs to reduce the incidental capture... 609 of Public Law 101-162 prohibits imports of certain categories of shrimp unless the President...

  12. 31 CFR 353.22 - Payment or reissue pursuant to judgment.

    Science.gov (United States)

    2010-07-01

    ... pursuant to judgment. (a) Divorce. The Department of the Treasury will recognize a divorce decree that... divorce decree does not set out the terms of the property settlement agreement, a certified copy of the... person found by a court to be entitled by reason of a gift causa mortis from the sole owner. (c) Date for...

  13. 7 CFR 1425.24 - OMB control number assigned pursuant to Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ...) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.24 OMB control number assigned pursuant to Paperwork Reduction Act. The... Office of Management and Budget (OMB) under the provisions of 44 U.S.C. Chapter 35 and have been assigned...

  14. 75 FR 70947 - Notice of Lodging of Consent Decree Pursuant to Oil Pollution Act

    Science.gov (United States)

    2010-11-19

    ... DEPARTMENT OF JUSTICE Notice of Lodging of Consent Decree Pursuant to Oil Pollution Act Notice is... claims of the United States (on behalf of the Department of Commerce/National Oceanic and Atmospheric..., and the State of Rhode Island for natural resource damages under the Oil Pollution Act, 33 U.S.C. 2701...

  15. 77 FR 28405 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2012-05-14

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Notice is hereby given that, on April 17, 2012... seq. (``the Act''), Petroleum Environmental Research Forum (``PERF'') has filed written notifications...

  16. 77 FR 61786 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2012-10-11

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Notice is hereby given that, on September 10....C. 4301 et seq. (``the Act''), Petroleum Environmental Research Forum (``PERF'') has filed written...

  17. 77 FR 54612 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2012-09-05

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Notice is hereby given that, on July 5, 2012... seq. (``the Act''), Petroleum Environmental Research Forum (``PERF'') has filed written notifications...

  18. 77 FR 26583 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2012-05-04

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Project No. 2011-01, Ultra Low Nutrient...''), Petroleum Environmental Research Forum (PERF) Project No. 2011-01, Ultra Low Nutrient Control in Wastewater...

  19. 77 FR 14046 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2012-03-08

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Notice is hereby given that, on January 31....C. 4301 et seq. (``the Act''), Petroleum Environmental Research Forum (``PERF'') has filed written...

  20. 76 FR 78044 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2011-12-15

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Notice is hereby given that, on November 1....C. 4301 et seq. (``the Act''), Petroleum Environmental Research Forum (``PERF'') has filed written...

  1. 75 FR 45156 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2010-08-02

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Notice is hereby given that, on June 2, 2010... seq. (``the Act''), Petroleum Environmental Research Forum (``PERF'') has filed written notifications...

  2. 77 FR 40086 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Petroleum...

    Science.gov (United States)

    2012-07-06

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Petroleum Environmental Research Forum Notice is hereby given that, on June 8, 2012... seq. (``the Act''), Petroleum Environmental Research Forum (``PERF'') has filed written notifications...

  3. 75 FR 20003 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Wireless...

    Science.gov (United States)

    2010-04-16

    ... circumstances. Specifically, Freescale Semiconductor, Inc., Austin, TX; and Cooper Industries, Houston, TX have... published a notice in the Federal Register pursuant to section 6(b) of the Act on September 18, 2008 (73 FR 54170). The last notification was filed with the Department on December 2, 2008. A notice was published...

  4. 75 FR 20003 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Connected Media...

    Science.gov (United States)

    2010-04-16

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and..., pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et... to the venture are: MXP4, Paris, FRANCE; Universal Music Group, Inc., Santa Monica, CA; Omediae, LLC...

  5. 75 FR 28294 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-The Applied...

    Science.gov (United States)

    2010-05-20

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--The Applied Nanotechnology Consortium Notice is hereby given that, on March 26, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et...

  6. 77 FR 40085 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-American Gap...

    Science.gov (United States)

    2012-07-06

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--American Gap Association Notice is hereby given that, on June 6, 2012, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq...

  7. 78 FR 55296 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-American Gap...

    Science.gov (United States)

    2013-09-10

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--American Gap Association Notice is hereby given that, on August 12, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq...

  8. 76 FR 77250 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

    Science.gov (United States)

    2011-12-12

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and... Prairie, MN, have been added as parties to this venture. Also, Actel Corporation, Mountain View, CA... Department of Justice published a notice in the Federal Register pursuant to Section 6(b) of the Act on...

  9. 78 FR 56939 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-IMS Global...

    Science.gov (United States)

    2013-09-16

    ..., Dell Inc., Austin, TX; Miami-Dade College--Virtual College, Miami, FL; National Labor College, Silver.... The Department of Justice published a notice in the Federal Register pursuant to Section 6(b) of the..., 2013. A notice was published in the Federal Register pursuant to Section 6(b) of the Act on June 21...

  10. 78 FR 37572 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Sematech, Inc. D...

    Science.gov (United States)

    2013-06-21

    ..., Windsor, Berkshire, UNITED KINGDOM; Freescale Semiconductor, Inc., Austin, TX; and TriQuint Semiconductors... pursuant to Section 6(a) of the Act. The Department of Justice published a notice in the Federal Register... Department on March 7, 2013. A notice was published in the Federal Register pursuant to Section 6(b) of the...

  11. 76 FR 72724 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Science.gov (United States)

    2011-11-25

    .... Specifically, Accurate Munition Systems, Inc., Austin, TX; Excelitas Technologies Sensors, Inc., Miamisburg, OH... Department of Justice published a notice in the Federal Register pursuant to Section 6(b) of the Act on June... notice was published in the Federal Register pursuant to Section 6(b) of the Act on September 23, 2011...

  12. 77 FR 34067 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Science.gov (United States)

    2012-06-08

    ..., 21 CT, Inc., Austin, TX; Cerebrus Corporation, Morris Plains, NJ; Conax Florida Corporation, St... Department of Justice published a notice in the Federal Register pursuant to Section 6(b) of the Act on June... notice was published in the Federal Register pursuant to Section 6(b) of the Act on March 15, 2012 (77 FR...

  13. 76 FR 79219 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Sematech, Inc. d...

    Science.gov (United States)

    2011-12-21

    ...., Hsinchu, TAIWAN; Global Foundaries Inc., Milpitas, CA; Freescale Semiconductor, Inc., Austin, TX; Infineon... notification pursuant to Section 6(a) of the Act. The Department of Justice published a notice in the Federal... with the Department on November 15, 2011. A notice was published in the Federal Register pursuant to...

  14. 78 FR 37572 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-U.S. Photovoltaic...

    Science.gov (United States)

    2013-06-21

    ... circumstances. Specifically, Esgee Technologies, Inc., Austin, TX; and Magnolia Solar, Albany, NY, have been... Justice published a notice in the Federal Register pursuant to Section 6(b) of the Act on December 21... was published in the Federal Register pursuant to Section 6(b) of the Act on February 12, 2013 (78 FR...

  15. Reporting of tangible fixed assets pursuant to the Czech accounting law and International Accounting Standards IAS/IFRS and US GAAP

    OpenAIRE

    Patrik Svoboda

    2007-01-01

    The valuation of assets is a relatively challenging activity as well as a scientific discipline having an impact on the amount of the reported assets and economic result process. The report deals with the issue of valuation of the tangible fixed assets in the accounting entities compiling the financial statements pursuant to the Czech national legislation and in conformity with the requirements of the International Accounting Standards IAS/IFRS and US GAAP. The substantial differences in the ...

  16. Neutrophil programming dynamics and its disease relevance.

    Science.gov (United States)

    Ran, Taojing; Geng, Shuo; Li, Liwu

    2017-11-01

    Neutrophils are traditionally considered as first responders to infection and provide antimicrobial host defense. However, recent advances indicate that neutrophils are also critically involved in the modulation of host immune environments by dynamically adopting distinct functional states. Functionally diverse neutrophil subsets are increasingly recognized as critical components mediating host pathophysiology. Despite its emerging significance, molecular mechanisms as well as functional relevance of dynamically programmed neutrophils remain to be better defined. The increasing complexity of neutrophil functions may require integrative studies that address programming dynamics of neutrophils and their pathophysiological relevance. This review aims to provide an update on the emerging topics of neutrophil programming dynamics as well as their functional relevance in diseases.

  17. [Relevant public health enteropathogens].

    Science.gov (United States)

    Riveros, Maribel; Ochoa, Theresa J

    2015-01-01

    Diarrhea remains the third leading cause of death in children under five years, despite recent advances in the management and prevention of this disease. It is caused by multiple pathogens, however, the prevalence of each varies by age group, geographical area and the scenario where cases (community vs hospital) are recorded. The most relevant pathogens in public health are those associated with the highest burden of disease, severity, complications and mortality. In our country, norovirus, Campylobacter and diarrheagenic E. coli are the most prevalent pathogens at the community level in children. In this paper we review the local epidemiology and potential areas of development in five selected pathogens: rotavirus, norovirus, Shiga toxin-producing E. coli (STEC), Shigella and Salmonella. Of these, rotavirus is the most important in the pediatric population and the main agent responsible for child mortality from diarrhea. The introduction of rotavirus vaccination in Peru will have a significant impact on disease burden and mortality from diarrhea. However, surveillance studies are needed to determine the impact of vaccination and changes in the epidemiology of diarrhea in Peru following the introduction of new vaccines, as well as antibiotic resistance surveillance of clinical relevant bacteria.

  18. Other relevant biological papers

    International Nuclear Information System (INIS)

    Shimizu, M.

    1989-01-01

    A considerable number of CRESP-relevant papers concerning deep-sea biology and radioecology have been published. It is the purpose of this study to call attention to them. They fall into three general categories. The first is papers of general interest. They are mentioned only briefly, and include text references to the global bibliography at the end of the volume. The second are papers that are not only mentioned and referenced, but for various reasons are described in abstract form. The last is a list of papers compiled by H.S.J. Roe specifically for this volume. They are listed in bibliographic form, and are also included in the global bibliography at the end of the volume

  19. 19 CFR 115.40 - Technical requirements for containers.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Technical requirements for containers. 115.40...; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers After Manufacture § 115.40 Technical requirements for...

  20. 10 CFR 490.306 - Vehicle operation requirements.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Vehicle operation requirements. 490.306 Section 490.306... Provider Vehicle Acquisition Mandate § 490.306 Vehicle operation requirements. The alternative fueled vehicles acquired pursuant to section 490.302 of this part shall be operated solely on alternative fuels...

  1. 49 CFR 1105.9 - Coastal Zone Management Act requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Coastal Zone Management Act requirements. 1105.9... ENVIRONMENTAL LAWS § 1105.9 Coastal Zone Management Act requirements. (a) If the proposed action affects land or water uses within a State coastal zone designated pursuant to the Coastal Zone Management Act (16 U.S.C...

  2. 20 CFR 1001.122 - Reporting and budget requirements.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Reporting and budget requirements. 1001.122... Services to Veterans and Eligible Persons § 1001.122 Reporting and budget requirements. (a) State agencies... agency shall make reports and prepare budgets pursuant to instructions issued by the ASVET and in such...

  3. Project Waiver of American Iron and Steel Requirements to the Napa Sanitation District for 24-Inch Diameter Butterfly Valves

    Science.gov (United States)

    Waiver approval by EPA pursuant to the American Iron and Steel Requirements of the Clean Water Act Section 608 to the Napa Sanitation District in California for the purchase of 24-inch butterfly valves.

  4. 76 FR 1459 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

    Science.gov (United States)

    2011-01-10

    ... Production Act of 1993-ASTM International Notice is hereby given that, on December 6, 2010, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the...

  5. 29 CFR 516.22 - Employees engaged in charter activities of carriers pursuant to section 7(n) of the Act.

    Science.gov (United States)

    2010-07-01

    ... respect to each employee employed in charter activities for a street, suburban or interurban electric railway or local trolley or motorbus carrier pursuant to section 7(n) of the Act, the employer shall...

  6. 7 CFR 1710.206 - Approval requirements for load forecasts prepared pursuant to approved load forecast work plans.

    Science.gov (United States)

    2010-01-01

    ... financial ratings, and participation in reliability council, power pool, regional transmission group, power... analysis and modeling of the borrower's electric system loads as provided for in the load forecast work plan. (5) A narrative discussing the borrower's past, existing, and forecast of future electric system...

  7. 17 CFR 289.101 - Schedule A. Information required in reports pursuant to § 289.3.

    Science.gov (United States)

    2010-04-01

    ... TO SECTION 13(a) OF THE INTERNATIONAL FINANCE CORPORATION ACT § 289.101 Schedule A. Information... allowed or paid to dealers. If any dealers are to act in the capacity of sub-underwriters and are to be...

  8. 48 CFR 9904.414-40 - Fundamental requirement.

    Science.gov (United States)

    2010-10-01

    .... 9904.414-40 Section 9904.414-40 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD... ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.414-40 Fundamental requirement. (a) A contractor's... money rate shall be based on rates determined by the Secretary of the Treasury, pursuant to Public Law...

  9. 8 CFR 1212.1 - Documentary requirements for nonimmigrants.

    Science.gov (United States)

    2010-01-01

    ... admissible. A passport is also required. (5) Aliens entering pursuant to International Boundary and Water... functions of the International Boundary and Water Commission, and entering the United States temporarily in... Republic, People's Republic of China, Colombia, Congo (Brazzaville), Cuba, India, Iran, Iraq, Libya...

  10. 24 CFR 92.222 - Reduction of matching contribution requirement.

    Science.gov (United States)

    2010-04-01

    ... major disaster pursuant to the Robert T. Stafford Disaster Relief and Emergency Assistance Act is made... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Reduction of matching contribution requirement. 92.222 Section 92.222 Housing and Urban Development Office of the Secretary, Department of...

  11. 40 CFR 86.407-78 - Certificate of conformity required.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Certificate of conformity required. 86... Regulations for 1978 and Later New Motorcycles, General Provisions § 86.407-78 Certificate of conformity... conformity issued pursuant to this subpart, except as specified in paragraph (b) of this section, or...

  12. Relevant Scatterers Characterization in SAR Images

    Science.gov (United States)

    Chaabouni, Houda; Datcu, Mihai

    2006-11-01

    Recognizing scenes in a single look meter resolution Synthetic Aperture Radar (SAR) images, requires the capability to identify relevant signal signatures in condition of variable image acquisition geometry, arbitrary objects poses and configurations. Among the methods to detect relevant scatterers in SAR images, we can mention the internal coherence. The SAR spectrum splitted in azimuth generates a series of images which preserve high coherence only for particular object scattering. The detection of relevant scatterers can be done by correlation study or Independent Component Analysis (ICA) methods. The present article deals with the state of the art for SAR internal correlation analysis and proposes further extensions using elements of inference based on information theory applied to complex valued signals. The set of azimuth looks images is analyzed using mutual information measures and an equivalent channel capacity is derived. The localization of the "target" requires analysis in a small image window, thus resulting in imprecise estimation of the second order statistics of the signal. For a better precision, a Hausdorff measure is introduced. The method is applied to detect and characterize relevant objects in urban areas.

  13. 77 FR 20051 - Notice of Final Determination Revising the List of Products Requiring Federal Contractor...

    Science.gov (United States)

    2012-04-03

    ... Products Requiring Federal Contractor Certification as to Forced or Indentured Child Labor Pursuant to... ``Procedural Guidelines for the Maintenance of the List of Products Requiring Federal Contractor Certification... List of Products Requiring Federal Contractor Certification as to Forced or Indentured Child Labor...

  14. Safety of hydroxytyrosol as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on hydroxytyrosol, which is chemically synthesised, as a novel food (NF) pursuant to Regulation (EC) No 258/97. The information provided on the comp......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on hydroxytyrosol, which is chemically synthesised, as a novel food (NF) pursuant to Regulation (EC) No 258/97. The information provided...... of hydroxytyrosol from the consumption of olive oils and olives, which has not been associated with adverse effects, and considering the similar kinetics of hydroxytyrosol in rats and humans, the Panel considers that the MoE for the NF at the intended uses and use levels is sufficient for the target population....... The Panel concludes that the novel food, hydroxytyrosol, is safe under the proposed uses and use levels....

  15. Profiles of Dialogue for Relevance

    Directory of Open Access Journals (Sweden)

    Douglas Walton

    2016-12-01

    Full Text Available This paper uses argument diagrams, argumentation schemes, and some tools from formal argumentation systems developed in artificial intelligence to build a graph-theoretic model of relevance shown to be applicable (with some extensions as a practical method for helping a third party judge issues of relevance or irrelevance of an argument in real examples. Examples used to illustrate how the method works are drawn from disputes about relevance in natural language discourse, including a criminal trial and a parliamentary debate.

  16. 76 FR 57653 - Bacillus thuringiensis eCry3.1Ab Protein in Corn; Temporary Exemption From the Requirement of a...

    Science.gov (United States)

    2011-09-16

    ... sensitivity to detect possible IgE epitopes without high false positive rates. 3. Prevalence in food... that would require EPA consideration of voluntary consensus standards pursuant to section 12(d) of the...

  17. Radiation Protection Ordinance 1989. Supplement with Radiation Protection Register Ordinance, general administration regulation pursuant to Sect. 45 Radiation Protection Ordinance, general administration regulation pursuant to Sect. 62 sub-sect. radiation passport

    International Nuclear Information System (INIS)

    Veith, H.M.

    1990-01-01

    The addendum contains regulations issued supplementary to the Radiation Protection Ordinance: The Radiation Protection Register as of April 3, 1990 including the law on the setting up of a Federal Office on Radiation Protection; the general administration regulation pursuant to Sect. 45 Radiation Protection Ordinance as of February 21, 1990; the general administration regulation pursuant to Sect. 62 sub-sect. 2 Radiation Protection Ordinance as of May 3, 1990 (AVV Radiation passport). The volume contains, apart from the legal texts, the appropriate decision by the Bundesrat, the official explanation from the Bundestag Publications as well as a comprehensive introduction into the new legal matter. (orig.) [de

  18. Relevance theory: pragmatics and cognition.

    Science.gov (United States)

    Wearing, Catherine J

    2015-01-01

    Relevance Theory is a cognitively oriented theory of pragmatics, i.e., a theory of language use. It builds on the seminal work of H.P. Grice(1) to develop a pragmatic theory which is at once philosophically sensitive and empirically plausible (in both psychological and evolutionary terms). This entry reviews the central commitments and chief contributions of Relevance Theory, including its Gricean commitment to the centrality of intention-reading and inference in communication; the cognitively grounded notion of relevance which provides the mechanism for explaining pragmatic interpretation as an intention-driven, inferential process; and several key applications of the theory (lexical pragmatics, metaphor and irony, procedural meaning). Relevance Theory is an important contribution to our understanding of the pragmatics of communication. © 2014 John Wiley & Sons, Ltd.

  19. Clinical relevance in anesthesia journals

    DEFF Research Database (Denmark)

    Lauritsen, Jakob; Møller, Ann M

    2006-01-01

    The purpose of this review is to present the latest knowledge and research on the definition and distribution of clinically relevant articles in anesthesia journals. It will also discuss the importance of the chosen methodology and outcome of articles.......The purpose of this review is to present the latest knowledge and research on the definition and distribution of clinically relevant articles in anesthesia journals. It will also discuss the importance of the chosen methodology and outcome of articles....

  20. The Relevant Physical Trace in Criminal Investigation

    Directory of Open Access Journals (Sweden)

    Durdica Hazard

    2016-01-01

    Full Text Available A criminal investigation requires the forensic scientist to search and to interpret vestiges of a criminal act that happened in the past. The forensic scientist is one of the many stakeholders who take part in the information quest within the criminal justice system. She reads the investigation scene in search of physical traces that should enable her to tell the story of the offense/crime that allegedly occurred. The challenge for any investigator is to detect and recognize relevant physical traces in order to provide clues for investigation and intelligence purposes, and that will constitute sound and relevant evidence for the court. This article shows how important it is to consider the relevancy of physical traces from the beginning of the investigation and what might influence the evaluation process. The exchange and management of information between the investigation stakeholders are important. Relevancy is a dimension that needs to be understood from the standpoints of law enforcement personnel and forensic scientists with the aim of strengthening investigation and ultimately the overall judicial process.

  1. Shippingport: A relevant decommissioning project

    International Nuclear Information System (INIS)

    Crimi, F.P.

    1988-01-01

    Because of Shippingport's low electrical power rating (72 MWe), there has been some misunderstanding on the relevancy of the Shippingport Station Decommissioning Project (SSDP) to a modern 1175 MWe commercial pressurized water reactor (PWR) power station. This paper provides a comparison of the major components of the reactor plant of the 72 MWe Shippingport Atomic Power Station and an 1175 MWe nuclear plant and the relevancy of the Shippingport decommissioning as a demonstration project for the nuclear industry. For the purpose of this comparison, Portland General Electric Company's 1175 MWe Trojan Nuclear Plant at Rainier, Oregon, has been used as the reference nuclear power plant. 2 refs., 2 figs., 1 tab

  2. 78 FR 9939 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-U.S. Photovoltaic...

    Science.gov (United States)

    2013-02-12

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--U.S. Photovoltaic Manufacturing Consortium, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), U.S. Photovoltaic Manufacturing Consortium, Inc. (``USPVMC...

  3. 78 FR 58559 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-U.S. Photovoltaic...

    Science.gov (United States)

    2013-09-24

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--U.S. Photovoltaic Manufacturing Consortium, Inc. Notice is hereby given that, on..., 15 U.S.C. 4301 et seq. (``the Act''), U.S. Photovoltaic Manufacturing Consortium, Inc. (``USPVMC...

  4. 76 FR 12370 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Green Seal, Inc.

    Science.gov (United States)

    2011-03-07

    ... and coatings, paper products, personal care products and service, restaurants and food services, and... recovery of antitrust plaintiffs to actual damages under specified circumstances. Pursuant to Section 6(b... are: Green Seal's standards focus on significant opportunities to reduce a product, service, or...

  5. 78 FR 46665 - Program for Allocation of Regulatory Responsibilities Pursuant to Rule 17d-2; Notice of Filing...

    Science.gov (United States)

    2013-08-01

    ... directors, governors, officers, employees or representatives. No warranties, express or implied, are made by... participant.\\12\\ On October 9, 2008, the Commission approved an amendment to the Plan to clarify that the term... relieved of regulatory responsibility for that common member, pursuant to the terms of the Plan, with...

  6. 15 CFR 30.63 - Office of Management and Budget control numbers assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Office of Management and Budget control numbers assigned pursuant to the Paperwork Reduction Act. 30.63 Section 30.63 Commerce and Foreign... FOREIGN TRADE REGULATIONS General Administrative Provisions § 30.63 Office of Management and Budget...

  7. 77 FR 5573 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Portland Cement...

    Science.gov (United States)

    2012-02-03

    ... Production Act of 1993--Portland Cement Association Notice is hereby given that, on January 6, 2012, pursuant... seq. (``the Act''), Portland Cement Association (``PCA'') has filed written notifications..., Newark, DE, has been added as a party to this venture. Also, Texas-Lehigh Cement Company, Buda, TX...

  8. 76 FR 34252 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; Portland Cement...

    Science.gov (United States)

    2011-06-13

    ... Production Act of 1993; Portland Cement Association Notice is hereby given that, on May 12, 2011, pursuant to.... (``the Act''), Portland Cement Association (``PCA'') has filed written notifications simultaneously with... plaintiffs to actual damages under specified circumstances. Specifically, Drake Cement, LLC, Scottsdale, AZ...

  9. 39 CFR 230.14 - Who owns the written or recorded notes, memoranda, reports, and transcriptions made pursuant to...

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Who owns the written or recorded notes, memoranda, reports, and transcriptions made pursuant to an official investigation, audit, or review conducted by an employee of the Office of Inspector General? 230.14 Section 230.14 Postal Service UNITED STATES POSTAL...

  10. 75 FR 30440 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

    Science.gov (United States)

    2010-06-01

    ... Production Act of 1993--ASTM International Notice is hereby given that, on May 6, 2010, pursuant to Section 6... Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the Attorney... recovery of antitrust plaintiffs to actual damages under specified circumstances. Specifically, ASTM has...

  11. 75 FR 11196 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

    Science.gov (United States)

    2010-03-10

    ... Production Act of 1993--ASTM International Notice is hereby given that, on February 16, 2010, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

  12. 75 FR 65657 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

    Science.gov (United States)

    2010-10-26

    ... Production Act of 1993--ASTM International Notice is hereby given that, on September 23, 2010, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

  13. 76 FR 63658 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; ASTM International

    Science.gov (United States)

    2011-10-13

    ... Production Act of 1993; ASTM International Notice is hereby given that, on August 31, 2011, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

  14. 77 FR 1085 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

    Science.gov (United States)

    2012-01-09

    ... Production Act of 1993--ASTM International Notice is hereby given that, on December 5, 2011, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

  15. 77 FR 5987 - Procedures of the Panel; Impasses Arising Pursuant to Agency Determinations Not To Establish or...

    Science.gov (United States)

    2012-02-07

    ... Pursuant to Agency Determinations Not To Establish or To Terminate Flexible or Compressed Work Schedules... agency determinations not to establish or terminate flexible or compressed work schedules, are as follows... Flexible or Compressed Work Schedules Section 2472.3 This section is amended to provide that copies of the...

  16. 76 FR 39963 - Order Pursuant to Section 36 of the Securities Exchange Act of 1934 Granting Temporary Exemptions...

    Science.gov (United States)

    2011-07-07

    ... Exchange Act Release No. 64017, supra note 9. \\16\\ The Commission stresses that the functions highlighted... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-64796; File No. S7-28-11] Order Pursuant to...- counter (``OTC'') market are centrally cleared.\\4\\ One of the key ways in which the Dodd-Frank Act seeks...

  17. 78 FR 32304 - Designation of Entity Pursuant to Executive Order 13224 of September 23, 2001, “Blocking Property...

    Science.gov (United States)

    2013-05-29

    ... Who Commit, Threaten To Commit, or Support Terrorism''; Identification of Entity Pursuant to Executive... Terrorism'' and Executive Order 13582 of August 17, 2011 ``Blocking Property of the Government of Syria and... with the Department of State, identified the entity listed below as falling within the definition of...

  18. 78 FR 73883 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Die Products...

    Science.gov (United States)

    2013-12-09

    ... Production Act of 1993--Die Products Consortium Notice is hereby given that, on November 7, 2013, pursuant to.... (``the Act''), Die Products Consortium (``DPC'') has filed written notifications simultaneously with the Attorney General and the Federal Trade Commission disclosing changes in its membership. The notifications...

  19. 75 FR 80536 - Notice Pursuant to the National Cooperative Research and Production Act of 1993 National Warheads...

    Science.gov (United States)

    2010-12-22

    ... Production Act of 1993 National Warheads and Energetics Consortium Notice is hereby given that, on November 30, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993... Mountain Scientific Laboratory, Centennial, CO; Rocky Research, Boulder City, NV; The Research Foundation...

  20. 76 FR 65749 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-TAI and Southwest...

    Science.gov (United States)

    2011-10-24

    ... Production Act of 1993--TAI and Southwest Research Institute Notice is hereby given that, on August 24, 2011, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et... tools research and development by organizing and implementing joint engineering and scientific research...

  1. 75 FR 79024 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

    Science.gov (United States)

    2010-12-17

    ... Production Act of 1993--ODVA, Inc. Notice is hereby given that, on November 15, 2010, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act..., Ontario, Canada; Hokuyo Automatic Co., Ltd., Osaka, Japan; Omron Scientific Technologies, Inc. (formerly...

  2. 75 FR 78338 - Meeting of the United States-Oman Joint Forum on Environmental Cooperation Pursuant to the United...

    Science.gov (United States)

    2010-12-15

    ... DEPARTMENT OF STATE [Public Notice 7261] Meeting of the United States-Oman Joint Forum on Environmental Cooperation Pursuant to the United States-Oman Memorandum of Understanding on Environmental Cooperation ACTION: Notice of the meeting of the U.S.-Oman Joint Forum on Environmental Cooperation and...

  3. 75 FR 34983 - Order (1) Pursuant to Section 4(c) of the Commodity Exchange Act, Permitting the Kansas City...

    Science.gov (United States)

    2010-06-21

    ... Act, Permitting the Kansas City Board of Trade Clearing Corporation To Clear Over-the-Counter Wheat Calendar Swaps and (2) Pursuant to Section 4d of the Commodity Exchange Act, Permitting Customer Positions... contract market, and its wholly- owned subsidiary corporation, the Kansas City Board of Trade Clearing...

  4. 78 FR 53193 - Designation of 4 Individuals Pursuant to Executive Order 13224 of September 23, 2001, “Blocking...

    Science.gov (United States)

    2013-08-28

    ... OFAC of the 4 individuals in this notice, pursuant to Executive Order 13224, are effective on August 22... Order; (2) foreign persons determined by the Secretary of State, in consultation with the Secretary of... by the Director of OFAC, in consultation with the Departments of State, Homeland Security and Justice...

  5. 78 FR 14622 - Designation of 1 Individual Pursuant to Executive Order 13224 of September 23, 2001, “Blocking...

    Science.gov (United States)

    2013-03-06

    ... Director of OFAC of the 1 individual in this notice, pursuant to Executive Order 13224, is effective on... Order; (2) foreign persons determined by the Secretary of State, in consultation with the Secretary of... by the Director of OFAC, in consultation with the Departments of State, Homeland Security and Justice...

  6. 77 FR 65055 - Designation of 1 individual Pursuant To Executive Order 13224 of September 23, 2001, Blocking...

    Science.gov (United States)

    2012-10-24

    ... Director of OFAC of the 1 individual in this notice, pursuant to Executive Order 13224, is effective on... Order; (2) foreign persons determined by the Secretary of State, in consultation with the Secretary of... by the Director of OFAC, in consultation with the Departments of State, Homeland Security and Justice...

  7. 75 FR 19357 - Honey From the People's Republic of China: Notice of Amended Final Results Pursuant to Final...

    Science.gov (United States)

    2010-04-14

    ... and Animal By-Products Import & Export Group Corp. v. United States, 2009 U.S. App. LEXIS 24374 (Fed... or Scot T. Fullerton, AD/CVD Operations, Office 9, Import Administration, U.S. Department of Commerce... Republic of China: Notice of Amended Final Results Pursuant to Final Court Decision AGENCY: Import...

  8. 28 CFR 16.26 - Considerations in determining whether production or disclosure should be made pursuant to a demand.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Considerations in determining whether production or disclosure should be made pursuant to a demand. 16.26 Section 16.26 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production or Disclosure in Federal...

  9. 78 FR 67401 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Advanced Media...

    Science.gov (United States)

    2013-11-12

    ... Production Act of 1993--Advanced Media Workflow Association, Inc. Notice is hereby given that, on September 24, 2013, pursuant to Section 6(a) of the National Cooperative Research and Production Act of 1993..., AudioVisual Preservation Solutions, New York, NY; Chellomedia Direct Programming, B.V., Amsterdam...

  10. 8 CFR 1240.16 - Application of new procedures or termination of proceedings in old proceedings pursuant to...

    Science.gov (United States)

    2010-01-01

    ... termination of proceedings in old proceedings pursuant to section 309(c) of Public Law 104-208. 1240.16 Section 1240.16 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE... to section 309(c) of Public Law 104-208. The Attorney General shall have the sole discretion to apply...

  11. 78 FR 58559 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cable Television...

    Science.gov (United States)

    2013-09-24

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cable Television Laboratories, Inc. Notice is hereby given that, on August 26, 2013... seq. (``the Act''), Cable Television Laboratories, Inc. (``CableLabs'') has filed written...

  12. 77 FR 74877 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; Cable Television...

    Science.gov (United States)

    2012-12-18

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993; Cable Television Laboratories, Inc. Notice is hereby given that, on November 13, 2012... seq. (``the Act''), Cable Television Laboratories, Inc. (``CableLabs'') has filed written...

  13. 78 FR 49770 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cable Television...

    Science.gov (United States)

    2013-08-15

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cable Television Laboratories, Inc. Notice is hereby given that, on July 9, 2013... seq. (``the Act''), Cable Television Laboratories, Inc. (``CableLabs'') has filed written...

  14. 78 FR 54277 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cable Television...

    Science.gov (United States)

    2013-09-03

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cable Television Laboratories, Inc. Notice is hereby given that, on August 1, 2013... seq. (``the Act''), Cable Television Laboratories, Inc. (``CableLabs'') has filed written...

  15. 75 FR 79025 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cable Television...

    Science.gov (United States)

    2010-12-17

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cable Television Laboratories, Inc. Notice is hereby given that, on November 4, 2010... seq. (``the Act''), Cable Television Laboratories, Inc. (``CableLabs'') has filed written...

  16. 77 FR 10808 - Designation of One Entity Pursuant to Executive Order 13572 of April 29, 2011, “Blocking Property...

    Science.gov (United States)

    2012-02-23

    ...'') pursuant to, inter alia, the International Emergency Economic Powers Act (50 U.S.C. 1701-06). In the Order... Designated Nationals and Blocked Persons appears as follows: Entity IRANIAN MINISTRY OF INTELLIGENCE AND...; Ministry of Intelligence, Second Negarestan Street, Pasdaran Avenue, Tehran, Iran [SYRIA]. Dated: February...

  17. 76 FR 59161 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Science.gov (United States)

    2011-09-23

    ...., Albuquerque, NM; Tetra Tech, Inc., Honolulu, HI; Trident Research, LLC, Austin, TX; Unified Design Corporation, Rockaway, NJ; and University of Texas at Austin, Austin, TX, have withdrawn as parties to this venture. No... pursuant to Section 6(a) of the Act. The Department of Justice published a notice in the Federal Register...

  18. 78 FR 16868 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National Warheads...

    Science.gov (United States)

    2013-03-19

    ..., PA; Systems and Materials Research Corporation, Austin, TX; and Targeted GeoSystems, LLC, Madison, AL... filed its original notification pursuant to Section 6(a) of the Act. The Department of Justice published...). The last notification was filed with the Department on November 13, 2012. A notice was published in...

  19. 76 FR 80405 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-PXI Systems...

    Science.gov (United States)

    2011-12-23

    ...; SignalCore Inc., Austin, TX; Modular Methods, LLC, Steamboat Springs, CO; and SELEX Galileo S.p.A., Roma... notification pursuant to Section 6(a) of the Act. The Department of Justice published a notice in the Federal... notification was filed with the Department on September 6, 2001. A notice was published in the Federal Register...

  20. 78 FR 33859 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-DIE Products...

    Science.gov (United States)

    2013-06-05

    ... Technologies, AG, Munich, Germany; Freescale Semiconductor, Inc., Austin, TX; Philips Semiconductors, Inc., San... original notification pursuant to Section 6(a) of the Act. The Department of Justice published a notice in... notification was filed with the Department on May 2, 2006. A notice was published in the Federal Register...

  1. 77 FR 26045 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Accellera Systems...

    Science.gov (United States)

    2012-05-02

    ..., IRELAND; Freescale Semiconductor, Austin, TX; IBM, Hopewell Junction, NY; Jasper Design Automation..., San Jose, CA; Vayavya Labs, Belguam, INDIA; Verilab, Austin, TX; and Xilinx, Inc., San Jose, CA, have.... The Department of Justice published a notice in the Federal Register pursuant to Section 6(b) of the...

  2. 24 CFR 213.259a - Premiums-mortgages insured pursuant to section 238(c) of the Act.

    Science.gov (United States)

    2010-04-01

    .... All of the provisions of §§ 213.253 through 213.259 governing mortgage insurance premiums shall apply... mortgage insurance premiums due on such mortgages in accordance with §§ 213.253 through 213.259 shall be... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Premiums-mortgages insured pursuant...

  3. 40 CFR 80.815 - What are the gasoline toxics performance requirements for refiners and importers?

    Science.gov (United States)

    2010-07-01

    ... toxics requirements of this subpart apply separately for each of the following types of gasoline produced...) The gasoline toxics performance requirements of this subpart apply to gasoline produced at a refinery... not apply to gasoline produced by a refinery approved under § 80.1334, pursuant to § 80.1334(c). (2...

  4. 75 FR 78755 - Notice of Initial Determination Revising the List of Products Requiring Federal Contractor...

    Science.gov (United States)

    2010-12-16

    ... Products Requiring Federal Contractor Certification as to Forced/Indentured Child Labor Pursuant to... products requiring federal contractor certification as to the use of forced or indentured child labor. To.... 13126 (``Prohibition of Acquisition of Products Produced by Forced or Indentured Child Labor''), in...

  5. 77 FR 59418 - Notice of Initial Determination Revising the List of Products Requiring Federal Contractor...

    Science.gov (United States)

    2012-09-27

    ... of products requiring federal contractor certification as to the use of forced or indentured child... DEPARTMENT OF LABOR Notice of Initial Determination Revising the List of Products Requiring Federal Contractor Certification as to Forced/Indentured Child Labor Pursuant to Executive Order 13126...

  6. 76 FR 61384 - Notice of Initial Determination Revising the List of Products Requiring Federal Contractor...

    Science.gov (United States)

    2011-10-04

    ... Maintenance of the List of Products Requiring Federal Contractor Certification as to Forced or Indentured... DEPARTMENT OF LABOR Notice of Initial Determination Revising the List of Products Requiring Federal Contractor Certification as to Forced/Indentured Child Labor Pursuant to Executive Order 13126...

  7. 75 FR 29404 - Contract Reporting Requirements of Intrastate Natural Gas Companies

    Science.gov (United States)

    2010-05-26

    ...; Order No. 735] Contract Reporting Requirements of Intrastate Natural Gas Companies May 20, 2010. AGENCY... revises the contract reporting requirements for those natural gas pipelines that fall under the Commission's jurisdiction pursuant to section 311 of the Natural Gas Policy Act or section 1(c) of the Natural...

  8. 75 FR 80758 - Storage Reporting Requirements of Interstate and Intrastate Natural Gas Companies

    Science.gov (United States)

    2010-12-23

    ...] Storage Reporting Requirements of Interstate and Intrastate Natural Gas Companies December 16, 2010... natural gas pipelines to report semi-annually on their storage activities. This Notice of Inquiry will... reports required of interstate and intrastate natural gas companies pursuant to 18 CFR 284.13(e) and 284...

  9. 7 CFR Appendix D to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Science.gov (United States)

    2010-01-01

    ...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30... 7 Agriculture 11 2010-01-01 2010-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30 D Appendix D to Subpart B of Part 1744...

  10. 7 CFR Appendix B to Subpart B of... - Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to...

    Science.gov (United States)

    2010-01-01

    ...—Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30... 7 Agriculture 11 2010-01-01 2010-01-01 false Certification of Independent Certified Public Accountant Regarding Notes To Be Issued Pursuant to 7 CFR 1744.30(c) B Appendix B to Subpart B of Part 1744...

  11. 75 FR 22864 - In the Matter of CAN USA, Inc., Harvey, Louisiana; General License Pursuant to 10 CFR 150.20...

    Science.gov (United States)

    2010-04-30

    ... CAN USA, Inc., Harvey, Louisiana; General License Pursuant to 10 CFR 150.20; Confirmatory Order (Effective Immediately) I CAN USA, Inc. (CAN USA or Licensee) is the holder of State of Louisiana Materials..., pursuant to 10 CFR 150.20(a)(1), CAN USA is granted a general license by the U.S. Nuclear Regulatory...

  12. Dramatic lives and relevant becomings

    DEFF Research Database (Denmark)

    Henriksen, Ann-Karina; Miller, Jody

    2012-01-01

    of marginality into positions of relevance. The analysis builds on empirical data from Copenhagen, Denmark, gained through ethnographic fieldwork with the participation of 20 female informants aged 13–22. The theoretical contribution proposes viewing conflicts as multi-linear, multi-causal and non...

  13. Regularization in Matrix Relevance Learning

    NARCIS (Netherlands)

    Schneider, Petra; Bunte, Kerstin; Stiekema, Han; Hammer, Barbara; Villmann, Thomas; Biehl, Michael

    A In this paper, we present a regularization technique to extend recently proposed matrix learning schemes in learning vector quantization (LVQ). These learning algorithms extend the concept of adaptive distance measures in LVQ to the use of relevance matrices. In general, metric learning can

  14. Functional dyspepsia: Are psychosocial factors of relevance?

    Institute of Scientific and Technical Information of China (English)

    Sandra Barry; Timothy G Dinan

    2006-01-01

    The pathogenesis of Functional Dyspepsia (FD) remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association between this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors within the syndrome of FD requires application of the biopsychosocial model of disease.Using this paradigm, dysregulation of the reciprocal communication between the brain and the gut is central to symptom generation, interpretation and exacerbation.Appreciation and understanding of the neurobiological correlates of various psychological states is also relevant.The view that psychosocial factors exert their influence in FD predominantly through motivation of health care seeking also persists. This appears too one-dimensional an assertion in light of the evidence available supporting a more intrinsic aetiological link. Evolving understanding of pathogenic mechanisms and the heterogeneous nature of the syndrome will facilitate effective management.Co-morbid psychiatric illness warrants treatment with conventional therapies. Acknowledging the relevance of psychosocial variables in FD, the degree of which is subject to variation, has implications for assessment and management. Available evidence suggests psychological therapies may benefit FD patients particularly those with chronic symptoms. The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited.

  15. 48 CFR 622.1503 - Procedures for acquiring end products on the List of Products Requiring Contractor Certification...

    Science.gov (United States)

    2010-10-01

    ... end products on the List of Products Requiring Contractor Certification as to Forced or Indentured... List of Products Requiring Contractor Certification as to Forced or Indentured Child Labor. (e) The... manufacture an end product furnished pursuant to a contract awarded subject to the certification required in...

  16. 75 FR 20785 - Polyglyceryl Phthalate Ester of Coconut Oil Fatty Acids; Exemption from the Requirement of a...

    Science.gov (United States)

    2010-04-21

    ... Phthalate Ester of Coconut Oil Fatty Acids; Exemption from the Requirement of a Tolerance; Technical... ester of coconut oil fatty acids; exemption from the requirement of a tolerance. This document is being... requirement of a tolerance for ``polyglyceryl phthalate ester of coconut oil fatty acids'' pursuant to a...

  17. The Improved Relevance Voxel Machine

    DEFF Research Database (Denmark)

    Ganz, Melanie; Sabuncu, Mert; Van Leemput, Koen

    The concept of sparse Bayesian learning has received much attention in the machine learning literature as a means of achieving parsimonious representations of features used in regression and classification. It is an important family of algorithms for sparse signal recovery and compressed sensing....... Hence in its current form it is reminiscent of a greedy forward feature selection algorithm. In this report, we aim to solve the problems of the original RVoxM algorithm in the spirit of [7] (FastRVM).We call the new algorithm Improved Relevance Voxel Machine (IRVoxM). Our contributions...... and enables basis selection from overcomplete dictionaries. One of the trailblazers of Bayesian learning is MacKay who already worked on the topic in his PhD thesis in 1992 [1]. Later on Tipping and Bishop developed the concept of sparse Bayesian learning [2, 3] and Tipping published the Relevance Vector...

  18. Alpha power gates relevant information during working memory updating.

    Science.gov (United States)

    Manza, Peter; Hau, Chui Luen Vera; Leung, Hoi-Chung

    2014-04-23

    Human working memory (WM) is inherently limited, so we must filter out irrelevant information in our environment or our mind while retaining limited important relevant contents. Previous work suggests that neural oscillations in the alpha band (8-14 Hz) play an important role in inhibiting incoming distracting information during attention and selective encoding tasks. However, whether alpha power is involved in inhibiting no-longer-relevant content or in representing relevant WM content is still debated. To clarify this issue, we manipulated the amount of relevant/irrelevant information using a task requiring spatial WM updating while measuring neural oscillatory activity via EEG and localized current sources across the scalp using a surface Laplacian transform. An initial memory set of two, four, or six spatial locations was to be memorized over a delay until an updating cue was presented indicating that only one or three locations remained relevant for a subsequent recognition test. Alpha amplitude varied with memory maintenance and updating demands among a cluster of left frontocentral electrodes. Greater postcue alpha power was associated with the high relevant load conditions (six and four dots cued to reduce to three relevant) relative to the lower load conditions (four and two dots reduced to one). Across subjects, this difference in alpha power was correlated with condition differences in performance accuracy. In contrast, no significant effects of irrelevant load were observed. These findings demonstrate that, during WM updating, alpha power reflects maintenance of relevant memory contents rather than suppression of no-longer-relevant memory traces.

  19. Microdosing: Concept, application and relevance

    Directory of Open Access Journals (Sweden)

    Tushar Tewari

    2010-01-01

    Full Text Available The use of microdose pharmacokinetic studies as an essential tool in drug development is still to catch on. While this approach promises potential cost savings and a quantum leap in efficiencies of the drug development process, major hurdles still need to be overcome before the technique becomes commonplace and part of routine practice. Clear regulations in Europe and the USA have had an enabling effect. The lack of enabling provisions for microdosing studies in Indian regulation, despite low risk and manifest relevance for the local drug development industry, is inconsistent with the country′s aspirations to be among the leaders in pharmaceutical research.

  20. 24 CFR 207.252c - Premiums-mortgages insured pursuant to section 238(c) of the Act.

    Science.gov (United States)

    2010-04-01

    .... All of the provisions of §§ 207.252 and 207.252a governing mortgage insurance premiums shall apply to... insurance premiums due on such mortgages in accordance with §§ 207.252 and 207.252a shall be calculated on... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Premiums-mortgages insured pursuant...

  1. A Compositional Relevance Model for Adaptive Information Retrieval

    Science.gov (United States)

    Mathe, Nathalie; Chen, James; Lu, Henry, Jr. (Technical Monitor)

    1994-01-01

    There is a growing need for rapid and effective access to information in large electronic documentation systems. Access can be facilitated if information relevant in the current problem solving context can be automatically supplied to the user. This includes information relevant to particular user profiles, tasks being performed, and problems being solved. However most of this knowledge on contextual relevance is not found within the contents of documents, and current hypermedia tools do not provide any easy mechanism to let users add this knowledge to their documents. We propose a compositional relevance network to automatically acquire the context in which previous information was found relevant. The model records information on the relevance of references based on user feedback for specific queries and contexts. It also generalizes such information to derive relevant references for similar queries and contexts. This model lets users filter information by context of relevance, build personalized views of documents over time, and share their views with other users. It also applies to any type of multimedia information. Compared to other approaches, it is less costly and doesn't require any a priori statistical computation, nor an extended training period. It is currently being implemented into the Computer Integrated Documentation system which enables integration of various technical documents in a hypertext framework.

  2. Other relevant numerical modelling papers

    International Nuclear Information System (INIS)

    Chartier, M.

    1989-01-01

    The ocean modelling is a rapidly evolving science and a large number of results have been published. Several categories of papers are of particular interest for this review: the papers published by the international atomic institutions, such as the NEA (for the CRESP or Subseabed Programs), the IAEA (for example the Safety Series, the Technical Report Series or the TECDOC), and the ICRP, and the papers concerned by more fundamental research, which are published in specific scientific literature. This paper aims to list some of the most relevant publications for the CRESP purposes. It means by no way to be exhaustive, but informative on the incontestable progress recently achieved in that field. One should note that some of these papers are so recent that their final version has not yet been published

  3. Industrial relevance of thermophilic Archaea.

    Science.gov (United States)

    Egorova, Ksenia; Antranikian, Garabed

    2005-12-01

    The dramatic increase of newly isolated extremophilic microorganisms, analysis of their genomes and investigations of their enzymes by academic and industrial laboratories demonstrate the great potential of extremophiles in industrial (white) biotechnology. Enzymes derived from extremophiles (extremozymes) are superior to the traditional catalysts because they can perform industrial processes even under harsh conditions, under which conventional proteins are completely denatured. In particular, enzymes from thermophilic and hyperthermophilic Archaea have industrial relevance. Despite intensive investigations, our knowledge of the structure-function relationships of their enzymes is still limited. Information concerning the molecular properties of their enzymes and genes has to be obtained to be able to understand the mechanisms that are responsible for catalytic activity and stability at the boiling point of water.

  4. The Relevance of Hegel's Logic

    Directory of Open Access Journals (Sweden)

    John W Burbidge

    2007-12-01

    Full Text Available Hegel defines his Logic as the science that thinks about thinking.nbsp; But when we interpret that work as outlining what happens when we reason we are vulnerable to Fregersquo;s charge of psychologism.nbsp; I use Hegelrsquo;s tripartite distinction among understanding, dialectical and speculative reason as operations of pure thought to suggest how thinking can work with objective concepts.nbsp; In the last analysis, however, our ability to move from the subjective contingency of representations and ideas to the pure concepts we think develops from mechanical memory, which separates sign from sense so hat we can focus simply on the latter.nbsp; By becoming aware of the connections that underlie our thinking processes we may be able to both move beyond the abstractions of symbolic logic and clarify what informal logicians call relevance.

  5. Relevance of randomised controlled trials in oncology.

    Science.gov (United States)

    Tannock, Ian F; Amir, Eitan; Booth, Christopher M; Niraula, Saroj; Ocana, Alberto; Seruga, Bostjan; Templeton, Arnoud J; Vera-Badillo, Francisco

    2016-12-01

    Well-designed randomised controlled trials (RCTs) can prevent bias in the comparison of treatments and provide a sound basis for changes in clinical practice. However, the design and reporting of many RCTs can render their results of little relevance to clinical practice. In this Personal View, we discuss the limitations of RCT data and suggest some ways to improve the clinical relevance of RCTs in the everyday management of patients with cancer. RCTs should ask questions of clinical rather than commercial interest, avoid non-validated surrogate endpoints in registration trials, and have entry criteria that allow inclusion of all patients who are fit to receive treatment. Furthermore, RCTs should be reported with complete accounting of frequency and management of toxicities, and with strict guidelines to ensure freedom from bias. Premature reporting of results should be avoided. The bar for clinical benefit should be raised for drug registration, which should require publication and review of mature data from RCTs, post-marketing health outcome studies, and value-based pricing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. The Relevance of Primary Education

    Science.gov (United States)

    Coe, John

    2018-01-01

    This article sketches a vision of how primary education needs to be re-shaped to let schools focus more sharply on the development of children as individuals. Rapid social change requires a fundamental re-thinking of formal education and assessment. High-stakes testing must end. Greater weight must be given to the application of knowledge and…

  7. 17 CFR 41.3 - Application for an exemptive order pursuant to section 4f(a)(4)(B) of the Act.

    Science.gov (United States)

    2010-04-01

    ..., or any broker or dealer exempt from floor broker or floor trader registration pursuant to section 4f... Commission may, in its sole discretion, grant the application, deny the application, decline to entertain the...

  8. 76 FR 36870 - Special Conditions: Gulfstream Model GVI Airplane; Design Roll Maneuver Requirement for...

    Science.gov (United States)

    2011-06-23

    ... issue a finding of regulatory adequacy pursuant to section 611 of Public Law 92-574, the ``Noise Control... Requirement for Electronic Flight Controls AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final... airplane will have a novel or unusual design feature associated with an electronic flight control system...

  9. 10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

    Science.gov (United States)

    2010-01-01

    ... nonpower reactors. 73.60 Section 73.60 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION... requirements for physical protection at nonpower reactors. Each nonpower reactor licensee who, pursuant to the... perform their duties. (6) Prior to entry into a material access area, packages shall be searched for...

  10. 76 FR 22611 - Specified Tax Return Preparers Required To File Individual Income Tax Returns Using Magnetic...

    Science.gov (United States)

    2011-04-22

    ... Specified Tax Return Preparers Required To File Individual Income Tax Returns Using Magnetic Media... Register on Wednesday, March 30, 2011 (76 FR 17521) providing guidance to specified tax return preparers who prepare and file individual income tax returns using magnetic media pursuant to section 6011(e)(3...

  11. 77 FR 28790 - Medical Loss Ratio Requirements Under the Patient Protection and Affordable Care Act

    Science.gov (United States)

    2012-05-16

    ... Internet Web site of the Department of Health and Human Services.'' In addition, section 1103(b) of the... other things, ``require the inclusion of information on the percentage of total premium revenue expended..., pursuant to this final rule, for the 2011 MLR reporting year. \\5\\ Source: Agency for Healthcare Research...

  12. 47 CFR 15.120 - Program blocking technology requirements for television receivers.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Program blocking technology requirements for television receivers. 15.120 Section 15.120 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO... transmitted pursuant to industry standard EIA/CEA-766-A “U.S. and Canadian Region Rating Tables (RRT) and...

  13. Vygotsky's Crisis: Argument, context, relevance.

    Science.gov (United States)

    Hyman, Ludmila

    2012-06-01

    Vygotsky's The Historical Significance of the Crisis in Psychology (1926-1927) is an important text in the history and philosophy of psychology that has only become available to scholars in 1982 in Russian, and in 1997 in English. The goal of this paper is to introduce Vygotsky's conception of psychology to a wider audience. I argue that Vygotsky's argument about the "crisis" in psychology and its resolution can be fully understood only in the context of his social and political thinking. Vygotsky shared the enthusiasm, widespread among Russian leftist intelligentsia in the 1920s, that Soviet society had launched an unprecedented social experiment: The socialist revolution opened the way for establishing social conditions that would let the individual flourish. For Vygotsky, this meant that "a new man" of the future would become "the first and only species in biology that would create itself." He envisioned psychology as a science that would serve this humanist teleology. I propose that The Crisis is relevant today insofar as it helps us define a fundamental problem: How can we systematically account for the development of knowledge in psychology? I evaluate how Vygotsky addresses this problem as a historian of the crisis. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Relevance of equilibrium in multifragmentation

    International Nuclear Information System (INIS)

    Furuta, Takuya; Ono, Akira

    2009-01-01

    The relevance of equilibrium in a multifragmentation reaction of very central 40 Ca + 40 Ca collisions at 35 MeV/nucleon is investigated by using simulations of antisymmetrized molecular dynamics (AMD). Two types of ensembles are compared. One is the reaction ensemble of the states at each reaction time t in collision events simulated by AMD, and the other is the equilibrium ensemble prepared by solving the AMD equation of motion for a many-nucleon system confined in a container for a long time. The comparison of the ensembles is performed for the fragment charge distribution and the excitation energies. Our calculations show that there exists an equilibrium ensemble that well reproduces the reaction ensemble at each reaction time t for the investigated period 80≤t≤300 fm/c. However, there are some other observables that show discrepancies between the reaction and equilibrium ensembles. These may be interpreted as dynamical effects in the reaction. The usual static equilibrium at each instant is not realized since any equilibrium ensemble with the same volume as that of the reaction system cannot reproduce the fragment observables

  15. Decree of the State Office for Nuclear Safety no. 146/1997 specifying nuclear safety-related activities and activities of special radiation protection relevance, requirements for qualification and professional education and training, procedures to examine special professional competence and to grant licences to selected personnel, and the format of documentation to be submitted when applying for selected personnel training licence

    International Nuclear Information System (INIS)

    Egermaier, J.

    2001-01-01

    The Decree is reproduced in the form of facsimile of the relevant pages of the official Collection of Laws of the Czech Republic, and accompanied by a commentary highlighting the past legislative developments and some aspects of this new document. (P.A.)

  16. Statistical significance versus clinical relevance.

    Science.gov (United States)

    van Rijn, Marieke H C; Bech, Anneke; Bouyer, Jean; van den Brand, Jan A J G

    2017-04-01

    In March this year, the American Statistical Association (ASA) posted a statement on the correct use of P-values, in response to a growing concern that the P-value is commonly misused and misinterpreted. We aim to translate these warnings given by the ASA into a language more easily understood by clinicians and researchers without a deep background in statistics. Moreover, we intend to illustrate the limitations of P-values, even when used and interpreted correctly, and bring more attention to the clinical relevance of study findings using two recently reported studies as examples. We argue that P-values are often misinterpreted. A common mistake is saying that P < 0.05 means that the null hypothesis is false, and P ≥0.05 means that the null hypothesis is true. The correct interpretation of a P-value of 0.05 is that if the null hypothesis were indeed true, a similar or more extreme result would occur 5% of the times upon repeating the study in a similar sample. In other words, the P-value informs about the likelihood of the data given the null hypothesis and not the other way around. A possible alternative related to the P-value is the confidence interval (CI). It provides more information on the magnitude of an effect and the imprecision with which that effect was estimated. However, there is no magic bullet to replace P-values and stop erroneous interpretation of scientific results. Scientists and readers alike should make themselves familiar with the correct, nuanced interpretation of statistical tests, P-values and CIs. © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

  17. A principled and cosmopolitan neuroethics: considerations for international relevance

    OpenAIRE

    Shook, John R; Giordano, James

    2014-01-01

    Neuroethics applies cognitive neuroscience for prescribing alterations to conceptions of self and society, and for prescriptively judging the ethical applications of neurotechnologies. Plentiful normative premises are available to ground such prescriptivity, however prescriptive neuroethics may remain fragmented by social conventions, cultural ideologies, and ethical theories. Herein we offer that an objectively principled neuroethics for international relevance requires a new meta-ethics: un...

  18. Does relevance matter in academic policy research?

    DEFF Research Database (Denmark)

    Dredge, Dianne

    2015-01-01

    A reflection on whether relevance matters in tourism policy research. A debate among tourism scholars.......A reflection on whether relevance matters in tourism policy research. A debate among tourism scholars....

  19. Safeguards Guidance Document for Designers of Commercial Nuclear Facilities: International Nuclear Safeguards Requirements and Practices For Uranium Enrichment Plants

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean; Casey Durst

    2009-10-01

    This report is the second in a series of guidelines on international safeguards requirements and practices, prepared expressly for the designers of nuclear facilities. The first document in this series is the description of generic international nuclear safeguards requirements pertaining to all types of facilities. These requirements should be understood and considered at the earliest stages of facility design as part of a new process called “Safeguards-by-Design.” This will help eliminate the costly retrofit of facilities that has occurred in the past to accommodate nuclear safeguards verification activities. The following summarizes the requirements for international nuclear safeguards implementation at enrichment plants, prepared under the Safeguards by Design project, and funded by the U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA), Office of NA-243. The purpose of this is to provide designers of nuclear facilities around the world with a simplified set of design requirements and the most common practices for meeting them. The foundation for these requirements is the international safeguards agreement between the country and the International Atomic Energy Agency (IAEA), pursuant to the Treaty on the Non-proliferation of Nuclear Weapons (NPT). Relevant safeguards requirements are also cited from the Safeguards Criteria for inspecting enrichment plants, found in the IAEA Safeguards Manual, Part SMC-8. IAEA definitions and terms are based on the IAEA Safeguards Glossary, published in 2002. The most current specification for safeguards measurement accuracy is found in the IAEA document STR-327, “International Target Values 2000 for Measurement Uncertainties in Safeguarding Nuclear Materials,” published in 2001. For this guide to be easier for the designer to use, the requirements have been restated in plainer language per expert interpretation using the source documents noted. The safeguards agreement is fundamentally a

  20. Thermochemical data for environmentally-relevant elements

    International Nuclear Information System (INIS)

    Markich, S.J.; Brown, P.L.

    1999-01-01

    This study provides an extensive stability constant (log K) database suitable for calculating the speciation of selected environmentally-relevant elements (H, Na, K, Ca, Mg, Fe, Mn, U, Al Pb, Zn, Cu and cd) in an aqueous system, where a model fulvic acid (comprising aspartic, citric, malonic, salicylic and tricarballylic acids) is used to simulate metal binding by dissolved organic material Stability constants for inorganic metal complexes and minerals were selected primarily from critical literature complications and/or reviews. In contrast, few critically evaluated data were available for metal complexes with aspartic, citric, malonic, salicylic and tricarballylic acids. Consequently, data from original research articles were carefully evaluated and compiled as part of the study, following defined selection criteria. to meet the objective of compiling a comprehensive and reliable database of stability constants, all relevant equilibria and species, ranging from simple binary metal complexes to more complex ternary and even quaternary, metal complexes were included where possible in addition to the selection of stability constants from empirical sources, estimates of stability constants were performed when this could be done reliably, based on the unified theory of metal ion complexation and/or linear tree energy relationships The stability constants are given as common logarithms (logo) in the form required by the HARPHRQ geochemical code and refer to the standard state, i.e 298.15 K (25 deg C), 10 5 Pa (1 atm) and, for all species, infinite dilution (ionic strength = 0 mol L -1 ). In addition to the compilation of stability constant data, an overview is given of geochemical speciation modelling in aqueous systems and available conceptual models of metal binding by humic substances. (authors)

  1. Science and the struggle for relevance

    NARCIS (Netherlands)

    Hessels, L.K.|info:eu-repo/dai/nl/304832863

    2010-01-01

    This thesis deals with struggles for relevance of university researchers, their efforts to make their work correspond with ruling standards of relevance and to influence these standards. Its general research question is: How to understand changes in the struggle for relevance of Dutch academic

  2. The Personal Relevance of the Social Studies.

    Science.gov (United States)

    VanSickle, Ronald L.

    1990-01-01

    Conceptualizes a personal-relevance framework derived from Ronald L. VanSickle's five areas of life integrated with four general motivating goals from Abraham Maslow's hierarchy of needs and Richard and Patricia Schmuck's social motivation theory. Illustrates ways to apply the personal relevance framework to make social studies more relevant to…

  3. The Development of Relevance in Information Retrieval

    Directory of Open Access Journals (Sweden)

    Mu-hsuan Huang

    1997-12-01

    Full Text Available This article attempts to investigate the notion of relevance in information retrieval. It discusses various definitions for relevance from historical viewpoints and the characteristics of relevance judgments. Also, it introduces empirical results of important related researches.[Article content in Chinese

  4. Nostalgia's place among self-relevant emotions.

    Science.gov (United States)

    van Tilburg, Wijnand A P; Wildschut, Tim; Sedikides, Constantine

    2017-07-24

    How is nostalgia positioned among self-relevant emotions? We tested, in six studies, which self-relevant emotions are perceived as most similar versus least similar to nostalgia, and what underlies these similarities/differences. We used multidimensional scaling to chart the perceived similarities/differences among self-relevant emotions, resulting in two-dimensional models. The results were revealing. Nostalgia is positioned among self-relevant emotions characterised by positive valence, an approach orientation, and low arousal. Nostalgia most resembles pride and self-compassion, and least resembles embarrassment and shame. Our research pioneered the integration of nostalgia among self-relevant emotions.

  5. Biology relevant to space radiation

    International Nuclear Information System (INIS)

    Fry, R.J.M.

    1997-01-01

    There are only very limited data on the health effects to humans from the two major components of the radiations in space, namely protons and heavy ions. As a result, predictions of the accompanying effects must be based either on (1) data generated through studies of experimental systems exposed on earth at rates and fluences higher than those in space, or (2) extrapolations from studies of gamma and x rays. Better information is needed about the doses, dose rates, and the energy and LET spectra of the radiations at the organ level that are anticipated to be encountered during extended space missions. In particular, there is a need for better estimates of the relationship between radiation quality and biological effects. In the case of deterministic effects, it is the threshold that is important. The possibility of the occurrence of a large solar particle event (SPE) requires that such effects be considered during extended space missions. Analyses suggest, however, that it is feasible to provide sufficient shielding so as to reduce such effects to acceptable levels, particularly if the dose rates can be limited. If these analyses prove correct, the primary biological risks will be the stochastic effects (latent cancer induction). The contribution of one large SPE to the risk of stochastic effects while undesirable will not be large in comparison to the potential total dose on a mission of long duration

  6. Dosimeter characteristics and service performance requirements

    International Nuclear Information System (INIS)

    Ambrosi, P.; Bartlett, D.T.

    1999-01-01

    The requirements for personal dosimeters and dosimetry services given by ICRP 26, ICRP 35, ICRP 60 and ICRP 75 are summarised and compared with the requirements given in relevant international standards. Most standards could be made more relevant to actual workplace conditions. In some standards, the required tests of energy and angular dependence of the response are not sufficient, or requirements on overall uncertainty are lacking. (author)

  7. 46 CFR 159.001-9 - OMB Control Numbers assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-10-01

    .... This section collects and displays the control numbers assigned to information collection and... Paperwork Reduction Act of 1980, (44 U.S.C. 3501 et seq.). The Coast Guard intends that this section comply with the requirements of 44 U.S.C. 3507(f) which requires that agencies display a current control...

  8. Software requirements

    CERN Document Server

    Wiegers, Karl E

    2003-01-01

    Without formal, verifiable software requirements-and an effective system for managing them-the programs that developers think they've agreed to build often will not be the same products their customers are expecting. In SOFTWARE REQUIREMENTS, Second Edition, requirements engineering authority Karl Wiegers amplifies the best practices presented in his original award-winning text?now a mainstay for anyone participating in the software development process. In this book, you'll discover effective techniques for managing the requirements engineering process all the way through the development cy

  9. Legal Aspects of Radioactive Waste Management: Relevant International Legal Instruments

    International Nuclear Information System (INIS)

    Wetherall, Anthony; Robin, Isabelle

    2014-01-01

    The responsible use of nuclear technology requires the safe and environmentally sound management of radioactive waste, for which countries need to have stringent technical, administrative and legal measures in place. The legal aspects of radioactive waste management can be found in a wide variety of legally binding and non-binding international instruments. This overview focuses on the most relevant ones, in particular those on nuclear safety, security, safeguards and civil liability for nuclear damage. It also identifies relevant regional instruments concerning environmental matters, in particular, with regard to strategic environmental assessments (SEAs), environmental impact assessments (EIAs), public access to information and participation in decision-making, as well as access to justice

  10. The pricing relevance of insider information; Die Preiserheblichkeit von Insiderinformationen

    Energy Technology Data Exchange (ETDEWEB)

    Kruse, Dominik

    2011-07-01

    The publication attempts to describe the so far discussion concerning the feature of pricing relevance and to develop it further with the aid of new research approaches. First, a theoretical outline is presented of the elementary regulation problem of insider trading, its historical development, and the regulation goals of the WpHG. This is followed by an analysis of the concrete specifications of the law. In view of the exemplarity of US law, a country with long experience in regulation of the capital market, the materiality doctrine of US insider law is gone into in some detail. The goals and development of the doctrine are reviewed in the light of court rulings. The third part outlines the requirements of German law in order to forecast the pricing relevance of insider information, while the final part presents a critical review of the current regulations on pricing relevance. (orig./RHM)

  11. Relevance: An Interdisciplinary and Information Science Perspective

    Directory of Open Access Journals (Sweden)

    Howard Greisdorf

    2000-01-01

    Full Text Available Although relevance has represented a key concept in the field of information science for evaluating information retrieval effectiveness, the broader context established by interdisciplinary frameworks could provide greater depth and breadth to on-going research in the field. This work provides an overview of the nature of relevance in the field of information science with a cursory view of how cross-disciplinary approaches to relevance could represent avenues for further investigation into the evaluative characteristics of relevance as a means for enhanced understanding of human information behavior.

  12. Requirements in engineering projects

    CERN Document Server

    Fernandes, João M

    2016-01-01

    This book focuses on various topics related to engineering and management of requirements, in particular elicitation, negotiation, prioritisation, and documentation (whether with natural languages or with graphical models). The book provides methods and techniques that help to characterise, in a systematic manner, the requirements of the intended engineering system.  It was written with the goal of being adopted as the main text for courses on requirements engineering, or as a strong reference to the topics of requirements in courses with a broader scope. It can also be used in vocational courses, for professionals interested in the software and information systems domain.   Readers who have finished this book will be able to: - establish and plan a requirements engineering process within the development of complex engineering systems; - define and identify the types of relevant requirements in engineering projects; - choose and apply the most appropriate techniques to elicit the requirements of a giv...

  13. 77 FR 16796 - Lead Requirements for Lead-Based Paint Activities in Target Housing and Child-Occupied Facilities...

    Science.gov (United States)

    2012-03-22

    ... document announces the receipt of Arkansas's rules established pursuant to its new 2011 statutory authority... program accreditation requirements, and work practice standards for lead-based paint activities in target...-based paint program and passed a new statute establishing a State lead-based paint program and changing...

  14. The Value Relevance of IFRS: The Case of Turkey

    Directory of Open Access Journals (Sweden)

    Ahmet Turel

    2009-10-01

    Full Text Available Accounting standards that are mostly compatible with International Financial Reporting Standards (IFRS are required for consolidatedfinancial statements of all Turkish listed firms starting from 2005 fiscal year end. Before that, financial reporting in Turkey was closely related to taxreporting. Until 2003, all Turkish listed firms were preparing their financial statements in accordance with the local standards issued by the CapitalMarket Board of Turkey. In this study, I examine the relative and incremental value relevance of earnings and the book value of equity under CapitalMarket Board (CMB Accounting Standards (2001-2002 and under IFRS (2005-2006 for Turkish listed firms. I compare these two periods toinvestigate whether the mandatory adoption of IFRS increase relevance of earnings and book value of equity which are accepted as proxies ofaccounting quality. I find evidence that the value relevance of earnings and book value of equity has increased significantly after adopting IFRS. Inaddition, I find that the incremental value relevance of earnings increased between the CMB accounting standards period and the IFRS period.However, the incremental value relevance of book value of equity degreased in the same period.

  15. L-carnitine and contribution to normal lipid metabolism: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2018-01-01

    Following an application from Lonza Ltd., submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scien......Following an application from Lonza Ltd., submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  16. Reporting of tangible fixed assets pursuant to the Czech accounting law and International Accounting Standards IAS/IFRS and US GAAP

    Directory of Open Access Journals (Sweden)

    Patrik Svoboda

    2007-01-01

    Full Text Available The valuation of assets is a relatively challenging activity as well as a scientific discipline having an impact on the amount of the reported assets and economic result process. The report deals with the issue of valuation of the tangible fixed assets in the accounting entities compiling the financial statements pursuant to the Czech national legislation and in conformity with the requirements of the International Accounting Standards IAS/IFRS and US GAAP. The substantial differences in the definitions and valuation of the tangible fixed assets in these systems have been determined, indicating the impact on the economy of the accounting entity, both at the primary acquisition and as at the day of the closing of books. Attention has also been paid to the possibilities of recording the value decreases and to subsequent expenses. The analysis of legal regulations was completed with the analysis of the financial statements from selected economic entities. As per the international standards, the main difference consists in the possibility of component depreciation of tangible assets or, on the other hand, the possibility of group depreciation, in the differences in valuation in the event of acquisition paid for and of acquisition by one’s own production, and in the possibility to consider the costs of disposal of assets. The subsequent expenses are also construed in a different manner: as per the Czech regulation, they are construed as repairs and maintenance. The substantial difference in comparison with the Czech regulation consists in the possibility of re-valuation of assets upwards as well as the method of actual value determination.

  17. Does relevance matter in academic policy research

    DEFF Research Database (Denmark)

    Dredge, Dianne

    2015-01-01

    A reflection on whether relevance matters in tourism policy research, and if so, to whom/what should it matter......A reflection on whether relevance matters in tourism policy research, and if so, to whom/what should it matter...

  18. Inoculating Relevance Feedback Against Poison Pills

    NARCIS (Netherlands)

    Dehghani, Mostafa; Azarbonyad, Hosein; Kamps, Jaap; Hiemstra, Djoerd; Marx, Maarten

    2016-01-01

    Relevance Feedback is a common approach for enriching queries, given a set of explicitly or implicitly judged documents to improve the performance of the retrieval. Although it has been shown that on average, the overall performance of retrieval will be improved after relevance feedback, for some

  19. Relevant cost information for order acceptance decisions

    NARCIS (Netherlands)

    Wouters, M.J.F.

    1997-01-01

    Some economic considerations for order acceptance decisions are discussed. The relevant economic considerations for order acceptance are widely discussed in the literature: only those costs are relevant which would be avoidable by not accepting the order incremental costs plus opportunity costs .

  20. Android Smartphone Relevance to Military Weather Applications

    Science.gov (United States)

    2011-10-01

    lithium -ion battery that may be replaced by the user (unlike Apple iPod Touch devices), thus spare batteries can be carried. If there is only sporadic...Android Smartphone Relevance to Military Weather Applications by David Sauter ARL-TR-5793 October 2011...Android Smartphone Relevance to Military Weather Applications David Sauter Computational and Information Sciences Directorate, ARL

  1. Using small XML elements to support relevance

    NARCIS (Netherlands)

    G. Ramirez Camps (Georgina); T.H.W. Westerveld (Thijs); A.P. de Vries (Arjen)

    2006-01-01

    htmlabstractSmall XML elements are often estimated relevant by the retrieval model but they are not desirable retrieval units. This paper presents a generic model that exploits the information obtained from small elements. We identify relationships between small and relevant elements and use this

  2. Translation as secondary communication. The relevance theory ...

    African Journals Online (AJOL)

    Ernst-August Gutt started one of the greatest translation debates of the past ten years when he suggested that relevance theory holds the key to providing a unified account of translation. The bulk of the debate has been between practitioners of functional equivalence and advocates of a relevance theoretic approach to ...

  3. Evolutionary relevance facilitates visual information processing.

    Science.gov (United States)

    Jackson, Russell E; Calvillo, Dusti P

    2013-11-03

    Visual search of the environment is a fundamental human behavior that perceptual load affects powerfully. Previously investigated means for overcoming the inhibitions of high perceptual load, however, generalize poorly to real-world human behavior. We hypothesized that humans would process evolutionarily relevant stimuli more efficiently than evolutionarily novel stimuli, and evolutionary relevance would mitigate the repercussions of high perceptual load during visual search. Animacy is a significant component to evolutionary relevance of visual stimuli because perceiving animate entities is time-sensitive in ways that pose significant evolutionary consequences. Participants completing a visual search task located evolutionarily relevant and animate objects fastest and with the least impact of high perceptual load. Evolutionarily novel and inanimate objects were located slowest and with the highest impact of perceptual load. Evolutionary relevance may importantly affect everyday visual information processing.

  4. Evolutionary Relevance Facilitates Visual Information Processing

    Directory of Open Access Journals (Sweden)

    Russell E. Jackson

    2013-07-01

    Full Text Available Visual search of the environment is a fundamental human behavior that perceptual load affects powerfully. Previously investigated means for overcoming the inhibitions of high perceptual load, however, generalize poorly to real-world human behavior. We hypothesized that humans would process evolutionarily relevant stimuli more efficiently than evolutionarily novel stimuli, and evolutionary relevance would mitigate the repercussions of high perceptual load during visual search. Animacy is a significant component to evolutionary relevance of visual stimuli because perceiving animate entities is time-sensitive in ways that pose significant evolutionary consequences. Participants completing a visual search task located evolutionarily relevant and animate objects fastest and with the least impact of high perceptual load. Evolutionarily novel and inanimate objects were located slowest and with the highest impact of perceptual load. Evolutionary relevance may importantly affect everyday visual information processing.

  5. 31 CFR 360.22 - Payment or reissue pursuant to divorce.

    Science.gov (United States)

    2010-07-01

    ... divorce. 360.22 Section 360.22 Money and Finance: Treasury Regulations Relating to Money and Finance... divorce. (a) Divorce. (1) The Department of the Treasury will recognize a divorce decree that ratifies or.... (2) The evidence required under § 360.23 must be submitted in every case. When the divorce decree...

  6. 75 FR 55295 - List of Rules To Be Reviewed Pursuant to the Regulatory Flexibility Act

    Science.gov (United States)

    2010-09-10

    ... securities held or to be acquired by the fund. The rule requires 17j-1 organizations to adopt codes of ethics... liability for manipulation under Sections 9(a)(2) and 10(b) of the Exchange Act, and Rule 10b-5 thereunder...

  7. 76 FR 79141 - List of Rules To Be Reviewed Pursuant to the Regulatory Flexibility Act

    Science.gov (United States)

    2011-12-21

    ... initial notice within a reasonable time after establishing a customer relationship in two additional..., requires an agency to review its rules that have a significant economic impact upon a substantial number of... be amended or rescinded * * * to minimize any significant economic impact of the rules upon a...

  8. 77 FR 15752 - Notice of Proposed Prospective Purchaser Agreement Amendment Pursuant to the Comprehensive...

    Science.gov (United States)

    2012-03-16

    ... modify or withdraw its consent to the PPA Amendment if comments received disclose facts or considerations... statutes, against the Pittsfield Economic Development Authority (``PEDA''). In lieu of financial consideration, in exchange for EPA's covenant not to sue, the PPA Amendment would require PEDA to acquire...

  9. Safety of UV-treated milk as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    2016-01-01

    nature raised by Member States. The novel food is cow’s milk (whole, semi-skimmed or skimmed) to which a treatment with ultraviolet (UV) radiation is applied after pasteurisation in order to extend the shelf life of the milk. This treatment results in an increase in the vitamin D3 concentrations......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on UV-treated milk as a novel food submitted pursuant to Regulation (EC) No 258/97, taking into account the comments and objections of a scientific...... of infants (up to 1 year of age). The Panel considers that it is unlikely that tolerable upper intake levels established by EFSA for children aged 1–10 years, adolescents and adults will be exceeded. The Panel considers that the novel food is not nutritionally disadvantageous. The data provided do not give...

  10. Safety of pyrroloquinoline quinone disodium salt as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on pyrroloquinoline quinone disodium salt (PQQ), trade name BioPQQTM, as a novel food pursuant to Regulation (EC) No 258/97. PQQ is produced...... by fermentation using Hyphomicrobium denitrificans CK-275 and purification process. PQQ has a minimum purity of 99.0%. The information provided on the composition, specifications, batch-to-batch variability, stability and production process of PQQ is sufficient and does not raise safety concerns. The applicant...... intends to market PQQ for use in food supplements for healthy adults, except pregnant and lactating women, at a maximum proposed level of consumption of 20 mg/day (corresponding to 0.29 mg/kg bw per day for a 70-kg person). The proposed level of consumption is at least 250 times higher than the estimated...

  11. Safety of dried aerial parts of Hoodia parviflora as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    provided on the composition, the specifications, the production process, the batch-to-batch variability and the stability of the NF is sufficient and does not raise safety concerns. The applicant intends to use the NF in a number of energy-reduced/sugar-free/no-added-sugar foods in quantities of up to 15......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the dried aerial parts of Hoodia parviflora as a novel food (NF) submitted pursuant to Regulation (EC) No 258/97. The information...... mg per serving. The applicant also proposes to provide the NF as a food supplement. The target population proposed by the applicant is adults. The highest intake estimates were found in the group of elderly (≥ 65 years) individuals, with a high intake of 1.0 mg/kg body weight (bw) per day. One 90-day...

  12. The value relevance of investment property fair value

    OpenAIRE

    Selas, Duarte Nuno Gonçalves da Costa

    2009-01-01

    A Work Project, presented as part of the requirements for the Award of a Masters Degree in Finance from the NOVA – School of Business and Economics This paper examines if the use of the fair value model is value relevant in companies where the investment properties are not their core business. An analysis is also made into whether the disclosed fair value of investment property is perceived by investors. The sample includes Portuguese listed companies subject to the mandatory adoption of I...

  13. Patient-relevant treatment goals in psoriasis.

    Science.gov (United States)

    Blome, Christine; Gosau, Ramona; Radtke, Marc A; Reich, Kristian; Rustenbach, Stephan J; Spehr, Christina; Thaçi, Diamant; Augustin, Matthias

    2016-03-01

    Patient-oriented care requires therapeutic decisions to agree with the patients' treatment needs and goals. This study addressed the following questions: What is important to psoriasis patients starting systemic treatment? How stable are these preferences within the first year of treatment? Are treatment goals associated with age, gender, or treatment success? The importance of treatment goals was assessed for patients with moderate-to-severe psoriasis in the German Psoriasis Registry (PsoBest) at baseline (onset of a systemic treatment; n = 3066) and at a 1-year follow-up (n = 1444) using the Patient Benefit Index (PBI). Treatment success was measured with PBI global score and Psoriasis Area Severity Index (PASI). Patients with moderate-to-severe psoriasis pursued a wide range of different goals. The most general treatment goals were rated most relevant, including skin healing and quick skin improvement (94.8/94.5 % "quite" or "very" important), confidence in the therapy (93.0 %), control over the disease (92.3 %), and a clear diagnosis and therapy (89.6 %). Further important goals related to not being in fear of the disease getting worse (84.8 %), reduction in itching (83.9 %), burning (70.6 %), and pain (60.6 %) as well as attaining a normal everyday life (78.4 %) and low treatment burden (64.2-77.9 %). Goals were mostly not associated with sex and gender. Goal importance slightly increased with treatment success. In a substantial proportion of patients (30.3-54.7 %) goal importance changed within 1 year after onset of systemic treatment. We conclude that treatment goal importance should be assessed in clinical practice on a regular basis.

  14. Closure requirements

    International Nuclear Information System (INIS)

    Hutchinson, I.P.G.; Ellison, R.D.

    1992-01-01

    Closure of a waste management unit can be either permanent or temporary. Permanent closure may be due to: economic factors which make it uneconomical to mine the remaining minerals; depletion of mineral resources; physical site constraints that preclude further mining and beneficiation; environmental, regulatory or other requirements that make it uneconomical to continue to develop the resources. Temporary closure can occur for a period of several months to several years, and may be caused by factors such as: periods of high rainfall or snowfall which prevent mining and waste disposal; economic circumstances which temporarily make it uneconomical to mine the target mineral; labor problems requiring a cessation of operations for a period of time; construction activities that are required to upgrade project components such as the process facilities and waste management units; and mine or process plant failures that require extensive repairs. Permanent closure of a mine waste management unit involves the provision of durable surface containment features to protect the waters of the State in the long-term. Temporary closure may involve activities that range from ongoing maintenance of the existing facilities to the installation of several permanent closure features in order to reduce ongoing maintenance. This paper deals with the permanent closure features

  15. Astrophysical relevance of γ transition energies

    International Nuclear Information System (INIS)

    Rauscher, Thomas

    2008-01-01

    The relevant γ energy range is explicitly identified where additional γ strength must be located to have an impact on astrophysically relevant reactions. It is shown that folding the energy dependences of the transmission coefficients and the level density leads to maximal contributions for γ energies of 2≤E γ ≤4 unless quantum selection rules allow isolated states to contribute. Under this condition, electric dipole transitions dominate. These findings allow us to more accurately judge the relevance of modifications of the γ strength for astrophysics

  16. Polydextrose and maintenance of normal defecation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from Tate & Lyle PLC submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  17. Vibigaba (germinated brown rice) and maintenance of normal blood pressure: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Loc Troi group, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  18. Anxiofit-1 and reduction of subthreshold and mild anxiety: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from Anxiofit Ltd. and ExtractumPharma Co Ltd., submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Hungary, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  19. Iron and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  20. Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  1. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2015-01-01

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  2. Curcumin and normal functioning of joints: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Suomen Terveysravinto Oy, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Finland, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  3. Vitamin E and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  4. DHA and improvement of memory function: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from DSM Nutritional Products, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...

  5. Calcium and contribution to the normal development of bones: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  6. 17 CFR 249.1100 - Form MSD, application for registration as a municipal securities dealer pursuant to rule 15Ba2-1...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form MSD, application for registration as a municipal securities dealer pursuant to rule 15Ba2-1 under the Securities Exchange Act of 1934 or amendment to such application. 249.1100 Section 249.1100 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED...

  7. 47 CFR 51.807 - Arbitration and mediation of agreements by the Commission pursuant to section 252(e)(5) of the Act.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Arbitration and mediation of agreements by the Commission pursuant to section 252(e)(5) of the Act. 51.807 Section 51.807 Telecommunication FEDERAL... Implementation of Section 252 of the Act § 51.807 Arbitration and mediation of agreements by the Commission...

  8. The foundation of the concept of relevance

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2010-01-01

    that what was regarded as the most fundamental view by Saracevic in 1975 has not since been considered (with very few exceptions). Other views, which are based on less fruitful assumptions, have dominated the discourse on relevance in information retrieval and information science. Many authors have...... reexamined the concept of relevance in information science, but have neglected the subject knowledge view, hence basic theoretical assumptions seem not to have been properly addressed. It is as urgent now as it was in 1975 seriously to consider “the subject knowledge view” of relevance (which may also...... be termed “the epistemological view”). The concept of relevance, like other basic concepts, is influenced by overall approaches to information science, such as the cognitive view and the domain-analytic view. There is today a trend toward a social paradigm for information science. This paper offers...

  9. Exploring Educational Quality and Relevance through Integrating ...

    African Journals Online (AJOL)

    Exploring Educational Quality and Relevance through Integrating Environmental and Social Issues in Science Education. ... However, the new contextualised concept of learning and teaching was applied only to one of them. A post-test was ...

  10. Has Financial Statement Information become Less Relevant?

    DEFF Research Database (Denmark)

    Thinggaard, Frank; Damkier, Jesper

    This paper presents insights into the question of whether accounting information based on the EU’s Accounting Directives has become less value-relevant to investors over time. The study is based on a research design first used by Francis and Schipper (1999), where value-relevance is measured......? The sample is based on non-financial companies listed on the Copenhagen Stock Exchange in the period 1984-2002. Our analyses show that all the applied accounting measures are value-relevant as investment strategies based on the information earn positive market-adjusted returns in our sample period....... The results provide some indication of a decline in the value-relevance of earnings information in the 1984-2001 period, and mixed, but not statistically reliable, evidence for accounting measures where book value information and asset values are also extracted from financial statements. The results seem...

  11. Users' requirements for IFMIF

    International Nuclear Information System (INIS)

    Noda, K.; Jitsukawa, S.; Ehrlich, K.; Moeslang, A.

    1998-01-01

    The International Fusion Materials Irradiation Facility (IFMIF) is a high energy neutron irradiation facility which generates an intense neutron flux with D-Li stripping reactions for fusion materials testing. The role of IFMIF is (1) development of various fusion reactor materials, (2) determination of design-relevant engineering databases for the DEMO fusion reactor, (3) calibration and validation of data generated from fission reactor irradiations and the other simulation experiments, etc. The conceptual design activity (CDA) of IFMIF was initiated in February 1995 as an IEA collaborative activity to complete a reference conceptual design of IFMIF in December 1996. Users' requirements for the conceptual design of IFMIF were developed for materials to be tested, types of experiments, small specimen test technology and irradiation conditions. Furthermore, the neutron irradiation field characteristics (spectrum, flux/volume, etc.) of IFMIF were evaluated for the conceptual design parameters and were shown to meet the essential requirements of the users. (orig.)

  12. Extending the Operational Relevance of the Current Heavy Mechanized and Armor Force to 2020 and Beyond

    National Research Council Canada - National Science Library

    Boston, Gerald

    2003-01-01

    Can the U.S. Army's current heavy mechanized and armor force adapt emerging Joint Vision 2020 operational concepts, in order to remain relevant to the land power requirements of combatant commanders across...

  13. Inferring relevance in a changing world

    Directory of Open Access Journals (Sweden)

    Robert C Wilson

    2012-01-01

    Full Text Available Reinforcement learning models of human and animal learning usually concentrate on how we learn the relationship between different stimuli or actions and rewards. However, in real world situations stimuli are ill-defined. On the one hand, our immediate environment is extremely multi-dimensional. On the other hand, in every decision-making scenario only a few aspects of the environment are relevant for obtaining reward, while most are irrelevant. Thus a key question is how do we learn these relevant dimensions, that is, how do we learn what to learn about? We investigated this process of representation learning experimentally, using a task in which one stimulus dimension was relevant for determining reward at each point in time. As in real life situations, in our task the relevant dimension can change without warning, adding ever-present uncertainty engendered by a constantly changing environment. We show that human performance on this task is better described by a suboptimal strategy based on selective attention and serial hypothesis testing rather than a normative strategy based on probabilistic inference. From this, we conjecture that the problem of inferring relevance in general scenarios is too computationally demanding for the brain to solve optimally. As a result the brain utilizes approximations, employing these even in simplified scenarios in which optimal representation learning is tractable, such as the one in our experiment.

  14. Study of the reactor relevance of the NET design concept

    International Nuclear Information System (INIS)

    Reynolds, P.; Worraker, W.J.

    1987-08-01

    The objective of the study was to explore the reactor relevance of NET, i.e. whether the technologies and design principles proposed for NET can be directly extrapolated to a demonstration power reactor (DEMO). The main areas of study were those near to the plasma, namely the divertor, first wall and tritium breeding blanket. Other aspects which were investigated were tritium permeation and recovery, reactor maintenance, afterheat and effects of disruptions. The principal results of the study are briefly presented; the details of the work are given in fourteen appendices. These appendices were selected for INIS and indexed separately. The overall conclusion of the study is that the NET design is only partly relevant to the design requirements of a DEMO reactor. (U.K.)

  15. New conducted electrical weapons: Electrical safety relative to relevant standards.

    Science.gov (United States)

    Panescu, Dorin; Nerheim, Max; Kroll, Mark W; Brave, Michael A

    2017-07-01

    We have previously published about TASER ® conducted electrical weapons (CEW) compliance with international standards. CEWs deliver electrical pulses that can inhibit a person's neuromuscular control or temporarily incapacitate. An eXperimental Rotating-Field (XRF) waveform CEW and the X2 CEW are new 2-shot electrical weapon models designed to target a precise amount of delivered charge per pulse. They both can deploy 1 or 2 dart pairs, delivered by 2 separate cartridges. Additionally, the XRF controls delivery of incapacitating pulses over 4 field vectors, in a rotating sequence. As in our previous study, we were motivated by the need to understand the cardiac safety profile of these new CEWs. The goal of this paper is to analyze the nominal electrical outputs of TASER XRF and X2 CEWs in reference to provisions of all relevant international standards that specify safety requirements for electrical medical devices and electrical fences. Although these standards do not specifically mention CEWs, they are the closest electrical safety standards and hence give very relevant guidance. The outputs of several TASER XRF and X2 CEWs were measured under normal operating conditions. The measurements were compared against manufacturer specifications. CEWs electrical output parameters were reviewed against relevant safety requirements of UL 69, IEC 60335-2-76 Ed 2.1, IEC 60479-1, IEC 60479-2, AS/NZS 60479.1, AS/NZS 60479.2, IEC 60601-1 and BS EN 60601-1. Our study confirmed that the nominal electrical outputs of TASER XRF and X2 CEWs lie within safety bounds specified by relevant standards.

  16. Passage relevance models for genomics search

    Directory of Open Access Journals (Sweden)

    Frieder Ophir

    2009-03-01

    Full Text Available Abstract We present a passage relevance model for integrating syntactic and semantic evidence of biomedical concepts and topics using a probabilistic graphical model. Component models of topics, concepts, terms, and document are represented as potential functions within a Markov Random Field. The probability of a passage being relevant to a biologist's information need is represented as the joint distribution across all potential functions. Relevance model feedback of top ranked passages is used to improve distributional estimates of query concepts and topics in context, and a dimensional indexing strategy is used for efficient aggregation of concept and term statistics. By integrating multiple sources of evidence including dependencies between topics, concepts, and terms, we seek to improve genomics literature passage retrieval precision. Using this model, we are able to demonstrate statistically significant improvements in retrieval precision using a large genomics literature corpus.

  17. Sentinel lymph node biopsy: clinical relevance

    International Nuclear Information System (INIS)

    Howman-Giles, R.

    2002-01-01

    accurate determination of sentinel nodes in all areas. There is a significant number of unusual and unexpected drainage patterns found in melanoma many of which would be undetectable if only using a gamma probe alone or delayed imaging with large particles. There is also some controversy in breast cancer on the most accurate sentinel node technique and the relevance of extra axillary drainage sites eg internal mammary chain. The sentinel lymph node mapping with lymphoscintigraphy and blue due in association with applications of the gamma probe at surgery for accurate localisation of sentinel nodes is making a significant impact on patient management. This is in particular by more accurate staging and prognostic information with better stratification of patients requiring further regional node dissection and those suitable for adjuvant therapy and specific clinical trials

  18. Identity theory and personality theory: mutual relevance.

    Science.gov (United States)

    Stryker, Sheldon

    2007-12-01

    Some personality psychologists have found a structural symbolic interactionist frame and identity theory relevant to their work. This frame and theory, developed in sociology, are first reviewed. Emphasized in the review are a multiple identity conception of self, identities as internalized expectations derived from roles embedded in organized networks of social interaction, and a view of social structures as facilitators in bringing people into networks or constraints in keeping them out, subsequently, attention turns to a discussion of the mutual relevance of structural symbolic interactionism/identity theory and personality theory, looking to extensions of the current literature on these topics.

  19. Safety of Ecklonia cava phlorotannins as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    /97. The novel food is a phlorotannin-rich alcohol extract of Ecklonia cava, which is an edible marine brown alga species. The information provided on the composition, the specifications, the production process and the batch-to-batch variability of the novel food is sufficient and does not raise safety concerns......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the safety of Ecklonia cava phlorotannins (marketed as SeaPolynolTM) as a novel food submitted pursuant to Regulation (EC) No 258....... The intention is to market the novel food as a food supplement for healthy individuals over the age of 12 years. A subchronic repeated dose oral toxicity study in rodents tested the novel food at daily doses of 0, 375, 750 and 1,500 mg/kg body weight (bw). The Panel considers the middose as the no...

  20. Bible Translation And Relevance Theory | Deist | Stellenbosch ...

    African Journals Online (AJOL)

    Stellenbosch Papers in Linguistics Plus. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 22 (1992) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Bible Translation And Relevance Theory. F Deist ...

  1. Seeking Relevance: American Political Science and America

    Science.gov (United States)

    Maranto, Robert; Woessner, Matthew C.

    2012-01-01

    In this article, the authors talk about the relevance of American political science and America. Political science has enormous strengths in its highly talented practitioners and sophisticated methods. However, its disconnection from its host society, while not so severe as for fields like English and sociology, nonetheless poses an existential…

  2. Is Enterprise Education Relevant to Social Enterprise?

    Science.gov (United States)

    Bridge, Simon

    2015-01-01

    Purpose: Both enterprise education and social enterprise have become fashionable but what, if any, should be the connections between them? The purpose of this paper is to explore those connections and to reflect on what relevance the two concepts might have for each other. Design/methodology/approach: Both enterprise education and social…

  3. Interpersonal communication: It's relevance to nursing practice ...

    African Journals Online (AJOL)

    This paper is aimed at highlighting how essential interpersonal communication is necessary for establishing rapport, understanding the needs of the patients and planning effective intervention for meeting holistic health care. To be continually relevant, Nurses have to improve on their communication skills to meet the ...

  4. Inferring feature relevances from metric learning

    DEFF Research Database (Denmark)

    Schulz, Alexander; Mokbel, Bassam; Biehl, Michael

    2015-01-01

    Powerful metric learning algorithms have been proposed in the last years which do not only greatly enhance the accuracy of distance-based classifiers and nearest neighbor database retrieval, but which also enable the interpretability of these operations by assigning explicit relevance weights...

  5. The Relevance of Causal Social Construction

    Directory of Open Access Journals (Sweden)

    Marques Teresa

    2017-02-01

    Full Text Available Social constructionist claims are surprising and interesting when they entail that presumably natural kinds are in fact socially constructed. The claims are interesting because of their theoretical and political importance. Authors like Díaz-León argue that constitutive social construction is more relevant for achieving social justice than causal social construction. This paper challenges this claim. Assuming there are socially salient groups that are discriminated against, the paper presents a dilemma: if there were no constitutively constructed social kinds, the causes of the discrimination of existing social groups would have to be addressed, and understanding causal social construction would be relevant to achieve social justice. On the other hand, not all possible constitutively socially constructed kinds are actual social kinds. If an existing social group is constitutively constructed as a social kind K, the fact that it actually exists as a K has social causes. Again, causal social construction is relevant. The paper argues that (i for any actual social kind X, if X is constitutively socially constructed as K, then it is also causally socially constructed; and (ii causal social construction is at least as relevant as constitutive social construction for concerns of social justice. For illustration, I draw upon two phenomena that are presumed to contribute towards the discrimination of women: (i the poor performance effects of stereotype threat, and (ii the silencing effects of gendered language use.

  6. The economic lot size and relevant costs

    NARCIS (Netherlands)

    Corbeij, M.H.; Jansen, R.A.; Grübström, R.W.; Hinterhuber, H.H.; Lundquist, J.

    1993-01-01

    In many accounting textbooks it is strongly argued that decisions should always be evaluated on relevant costs; that is variable costs and opportunity costs. Surprisingly, when it comes to Economic Order Quantities or Lot Sizes, some textbooks appear to be less straightforward. The question whether

  7. Bootstrapping Visual Categorization with Relevant Negatives

    NARCIS (Netherlands)

    Li, X.; Snoek, C.G.M.; Worring, M.; Koelma, D.; Smeulders, A.W.M.

    Learning classifiers for many visual concepts are important for image categorization and retrieval. As a classifier tends to misclassify negative examples which are visually similar to positive ones, inclusion of such misclassified and thus relevant negatives should be stressed during learning.

  8. Why ritual plant use has ethnopharmacological relevance

    NARCIS (Netherlands)

    Quiroz, Diana; Sosef, Marc; Andel, Van Tinde

    2016-01-01

    Ethnopharmacological relevance Although ritual plant use is now recognised both for its socio-cultural importance and for its contribution to nature conservation, its potential pharmacological effects remain overlooked. Aim of the study Our objective was to see whether ritual plant use could have

  9. Bradford's Law and Its Relevance to Researchers

    Science.gov (United States)

    Shenton, Andrew K.; Hay-Gibson, Naomi V.

    2009-01-01

    Bradford's Law has been the subject of much discussion and analysis in library and information science since its formulation in the 1930s and remains frequently debated to this day. It has been applied to various practices within the discipline, especially with regard to collection development, but its relevance to researchers and the potential it…

  10. The relevance of cosmopolitanism for moral education

    NARCIS (Netherlands)

    Merry, M.S.; de Ruyter, D.J.

    2011-01-01

    In this article we defend a moral conception of cosmopolitanism and its relevance for moral education. Our moral conception of cosmopolitanism presumes that persons possess an inherent dignity in the Kantian sense and therefore they should be recognised as ends-in-themselves. We argue that

  11. Ranking Music Data by Relevance and Importance

    DEFF Research Database (Denmark)

    Ruxanda, Maria Magdalena; Nanopoulos, Alexandros; Jensen, Christian Søndergaard

    2008-01-01

    Due to the rapidly increasing availability of audio files on the Web, it is relevant to augment search engines with advanced audio search functionality. In this context, the ranking of the retrieved music is an important issue. This paper proposes a music ranking method capable of flexibly fusing...

  12. Fast multi-output relevance vector regression

    OpenAIRE

    Ha, Youngmin

    2017-01-01

    This paper aims to decrease the time complexity of multi-output relevance vector regression from O(VM^3) to O(V^3+M^3), where V is the number of output dimensions, M is the number of basis functions, and V

  13. Pragmatic inferences and self-relevant judgments

    DEFF Research Database (Denmark)

    Puente-Diaz, Rogelio; Cavazos Arroyo, Judith; Brem, Alexander

    2016-01-01

    Three studies examined the influence of type of scale on self-relevant judgments and the moderating role of age, prevention, focus, and need for cogni- tion. Participants were randomly assigned to a bipolar or a unipolar scale condition in all three studies. Results from study 1 with a representa...

  14. Making Chemistry Relevant to the Engineering Major

    Science.gov (United States)

    Basu-Dutt, Sharmistha; Slappey, Charles; Bartley, Julie K.

    2010-01-01

    As part of a campus-wide, externally funded project to increase performance in, enthusiasm for, and retention within STEM disciplines, we developed an interdisciplinary, team-taught first-year seminar course. The construction and delivery of this course was designed to show the relevance of selected general chemistry topics such as matter and…

  15. Contingent Attentional Capture by Conceptually Relevant Images

    Science.gov (United States)

    Wyble, Brad; Folk, Charles; Potter, Mary C.

    2013-01-01

    Attentional capture is an unintentional shift of visuospatial attention to the location of a distractor that is either highly salient, or relevant to the current task set. The latter situation is referred to as contingent capture, in that the effect is contingent on a match between characteristics of the stimuli and the task-defined…

  16. The Relevance Aura of Bibliographic Records.

    Science.gov (United States)

    Brooks, Terrence A.

    1997-01-01

    Analyzes relevance assessments of topical descriptors for bibliographic records for two dimensions: (1) a vertical conceptual hierarchy of broad to narrow descriptors, and (2) a horizontal linkage of related terms. The data were analyzed for a semantic distance and semantic direction effect as postulated by the Semantic Distance Model. (Author/LRW)

  17. The Relevance of Cosmopolitanism for Moral Education

    Science.gov (United States)

    Merry, Michael S.; de Ruyter, Doret J.

    2011-01-01

    In this article we defend a moral conception of cosmopolitanism and its relevance for moral education. Our moral conception of cosmopolitanism presumes that persons possess an inherent dignity in the Kantian sense and therefore they should be recognised as ends-in-themselves. We argue that cosmopolitan ideals can inspire moral educators to awaken…

  18. Radiologic evaluation of the horse relevant to purchase

    International Nuclear Information System (INIS)

    Poulos, P.W. Jr.

    1992-01-01

    Adequate radiographic evaluation of the horse relevant to purchase examination requires the successful integration of technique, interpretation, and reporting. A thorough knowledge of lameness and disease can be masked by incorrect interpretation resulting from poor-quality films or an incomplete examination. Thus, care must be taken to produce an adequate number of high-quality films on which to base a report, which allows you to describe changes that are present. This information, coupled with your physical examination, other laboratory data, and the knowledge of the expressed use of the horse will allow you to advise prospective owners on the decision that they will ultimately make

  19. Social relevance enhances memory for impressions in older adults.

    Science.gov (United States)

    Cassidy, Brittany S; Gutchess, Angela H

    2012-01-01

    Previous research has demonstrated that older adults have difficulty retrieving contextual material over items alone. Recent research suggests this deficit can be reduced by adding emotional context, allowing for the possibility that memory for social impressions may show less age-related decline than memory for other types of contextual information. Two studies investigated how orienting to social or self-relevant aspects of information contributed to the learning and retrieval of impressions in young and older adults. Participants encoded impressions of others in conditions varying in the use of self-reference (Experiment 1) and interpersonal meaningfulness (Experiment 2), and completed memory tasks requiring the retrieval of specific traits. For both experiments, age groups remembered similar numbers of impressions. In Experiment 1 using more self-relevant encoding contexts increased memory for impressions over orienting to stimuli in a non-social way, regardless of age. In Experiment 2 older adults had enhanced memory for impressions presented in an interpersonally meaningful relative to a personally irrelevant way, whereas young adults were unaffected by this manipulation. The results provide evidence that increasing social relevance ameliorates age differences in memory for impressions, and enhances older adults' ability to successfully retrieve contextual information.

  20. Relevance of motion-related assessment metrics in laparoscopic surgery.

    Science.gov (United States)

    Oropesa, Ignacio; Chmarra, Magdalena K; Sánchez-González, Patricia; Lamata, Pablo; Rodrigues, Sharon P; Enciso, Silvia; Sánchez-Margallo, Francisco M; Jansen, Frank-Willem; Dankelman, Jenny; Gómez, Enrique J

    2013-06-01

    Motion metrics have become an important source of information when addressing the assessment of surgical expertise. However, their direct relationship with the different surgical skills has not been fully explored. The purpose of this study is to investigate the relevance of motion-related metrics in the evaluation processes of basic psychomotor laparoscopic skills and their correlation with the different abilities sought to measure. A framework for task definition and metric analysis is proposed. An explorative survey was first conducted with a board of experts to identify metrics to assess basic psychomotor skills. Based on the output of that survey, 3 novel tasks for surgical assessment were designed. Face and construct validation was performed, with focus on motion-related metrics. Tasks were performed by 42 participants (16 novices, 22 residents, and 4 experts). Movements of the laparoscopic instruments were registered with the TrEndo tracking system and analyzed. Time, path length, and depth showed construct validity for all 3 tasks. Motion smoothness and idle time also showed validity for tasks involving bimanual coordination and tasks requiring a more tactical approach, respectively. Additionally, motion smoothness and average speed showed a high internal consistency, proving them to be the most task-independent of all the metrics analyzed. Motion metrics are complementary and valid for assessing basic psychomotor skills, and their relevance depends on the skill being evaluated. A larger clinical implementation, combined with quality performance information, will give more insight on the relevance of the results shown in this study.

  1. 75 FR 42283 - Review of Arbitration Awards; Miscellaneous and General Requirements

    Science.gov (United States)

    2010-07-21

    ... supported the provision of assistance from the Authority's Collaboration and Alternative Dispute Resolution... that ``the requirements and relevant material regarding alternative dispute resolution be set forth... regulation set forth ``the requirements and relevant material regarding alternative dispute resolution...

  2. Getting Grip on Security Requirements Elicitation by Structuring and Reusing Security Requirements Sources

    Directory of Open Access Journals (Sweden)

    Christian Schmitt

    2015-07-01

    Full Text Available This paper presents a model for structuring and reusing security requirements sources. The model serves as blueprint for the development of an organization-specific repository, which provides relevant security requirements sources, such as security information and knowledge sources and relevant compliance obligations, in a structured and reusable form. The resulting repository is intended to be used by development teams during the elicitation and analysis of security requirements with the goal to understand the security problem space, incorporate all relevant requirements sources, and to avoid unnecessary effort for identifying, understanding, and correlating applicable security requirements sources on a project-wise basis. We start with an overview and categorization of important security requirements sources, followed by the description of the generic model. To demonstrate the applicability and benefits of the model, the instantiation approach and details of the resulting repository of security requirements sources are presented.

  3. Tomographic diagnosis and relevant aspects of otosclerosis

    International Nuclear Information System (INIS)

    Gaiotti, Juliana Oggioni; Gomes, Natalia Delage; Costa, Ana Maria Doffemond; Villela, Caroline Laurita Batista Couto; Moreira, Wanderval; Diniz, Renata Lopes Furletti Caldeira

    2013-01-01

    A literature review and pictorial essay were developed to discuss the importance of knowing the main findings and locations of otosclerosis at multidetector computed tomography (MDCT). The authors performed a retrospective review of cases of otosclerosis diagnosed in their institution by means of high resolution multidetector computed tomography. Otosclerosis corresponds to otic capsule dysplasia characterized by metabolic derangement of its endochondral layer. Such condition constitutes a relevant cause of sensorineural hearing loss, affecting about 7% to 10% of the general population. The diagnosis is usually clinical, but imaging methods play a significant role in the anatomical detailing, differential diagnosis, surgical planning and evaluation of postoperative complications. Among such methods, the relevance of MDCT is highlighted. Radiologists should be familiar with the MDCT findings of otosclerosis, as well as with the temporal bone anatomy to assist in the appropriate clinical management of this disease. (author)

  4. Tomographic diagnosis and relevant aspects of otosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Gaiotti, Juliana Oggioni; Gomes, Natalia Delage; Costa, Ana Maria Doffemond; Villela, Caroline Laurita Batista Couto; Moreira, Wanderval; Diniz, Renata Lopes Furletti Caldeira, E-mail: jugaiotti@gmail.com [Hospital Mater Dei-Mater Imagem, Belo Horizonte, MG (Brazil)

    2013-09-15

    A literature review and pictorial essay were developed to discuss the importance of knowing the main findings and locations of otosclerosis at multidetector computed tomography (MDCT). The authors performed a retrospective review of cases of otosclerosis diagnosed in their institution by means of high resolution multidetector computed tomography. Otosclerosis corresponds to otic capsule dysplasia characterized by metabolic derangement of its endochondral layer. Such condition constitutes a relevant cause of sensorineural hearing loss, affecting about 7% to 10% of the general population. The diagnosis is usually clinical, but imaging methods play a significant role in the anatomical detailing, differential diagnosis, surgical planning and evaluation of postoperative complications. Among such methods, the relevance of MDCT is highlighted. Radiologists should be familiar with the MDCT findings of otosclerosis, as well as with the temporal bone anatomy to assist in the appropriate clinical management of this disease. (author)

  5. EOG feature relevance determination for microsleep detection

    OpenAIRE

    Golz Martin; Wollner Sebastian; Sommer David; Schnieder Sebastian

    2017-01-01

    Automatic relevance determination (ARD) was applied to two-channel EOG recordings for microsleep event (MSE) recognition. 10 s immediately before MSE and also before counterexamples of fatigued, but attentive driving were analysed. Two type of signal features were extracted: the maximum cross correlation (MaxCC) and logarithmic power spectral densities (PSD) averaged in spectral bands of 0.5 Hz width ranging between 0 and 8 Hz. Generalised learn-ing vector quantisation (GRLVQ) was used as ARD...

  6. Is QCD relevant to nuclear physics

    International Nuclear Information System (INIS)

    Thomas, A.W.

    1985-01-01

    A review is given of recent work on baryon structure in a number of QCD-motivated models. After establishing a prima facie case that the quark model should be relevant in a consistent description of the nucleus over a wide range of momentum transfer, the author looks for experimental confirmation. The discussion includes the search for exotic states, for a six quark component of the deuteron, and an up to date report on the interpretation of the EMC effect. (Auth.)

  7. Trade Off Relevance Dan Reliability: Isu Ifrs

    OpenAIRE

    Mahmudah, Hadi

    2013-01-01

    Financial reports containing qualitative characteristic that are useful for usernya.For a long time believed to be the existence of trade off between characteristic of qualitative relevance and reliability. Trade off due to the fact that the use of the method of measurement historical cost and fair value. Trade off occur because of the interests of for the purpose of the preparation of reports on finance. Accountability for the purpose of the measurement of the cost of historical still reliab...

  8. Hydrogen interaction with fusion-relevant materials

    International Nuclear Information System (INIS)

    Caorlin, M.

    1990-01-01

    This paper is an outline of the work carried out at JRC Ispra in the Tritium-materials Interaction Laboratory, on the interaction of gaseous hydrogen with several materials of interest in the field of fusion technology. Experimental work is reported and a concise review of relevant theoretical and numerical supporting activity is given as well. A period of about seven years is covered since 1982. Current work and possible future extensions are also briefly mentioned. 11 figs., 18 refs

  9. Nanostructure symmetry: Relevance for physics and computing

    International Nuclear Information System (INIS)

    Dupertuis, Marc-André; Oberli, D. Y.; Karlsson, K. F.; Dalessi, S.; Gallinet, B.; Svendsen, G.

    2014-01-01

    We review the research done in recent years in our group on the effects of nanostructure symmetry, and outline its relevance both for nanostructure physics and for computations of their electronic and optical properties. The exemples of C3v and C2v quantum dots are used. A number of surprises and non-trivial aspects are outlined, and a few symmetry-based tools for computing and analysis are shortly presented

  10. Nanostructure symmetry: Relevance for physics and computing

    Energy Technology Data Exchange (ETDEWEB)

    Dupertuis, Marc-André; Oberli, D. Y. [Laboratory for Physics of Nanostructure, EPF Lausanne (Switzerland); Karlsson, K. F. [Department of Physics, Chemistry, and Biology (IFM), Linköping University (Sweden); Dalessi, S. [Computational Biology Group, Department of Medical Genetics, University of Lausanne (Switzerland); Gallinet, B. [Nanophotonics and Metrology Laboratory, EPF Lausanne (Switzerland); Svendsen, G. [Dept. of Electronics and Telecom., Norwegian University of Science and Technology, Trondheim (Norway)

    2014-03-31

    We review the research done in recent years in our group on the effects of nanostructure symmetry, and outline its relevance both for nanostructure physics and for computations of their electronic and optical properties. The exemples of C3v and C2v quantum dots are used. A number of surprises and non-trivial aspects are outlined, and a few symmetry-based tools for computing and analysis are shortly presented.

  11. Monochloramine Cometabolism by Nitrifying Biofilm Relevant ...

    Science.gov (United States)

    Recently, biological monochloramine removal (i.e., cometabolism) by a pure culture ammonia–oxidizing bacteria, Nitrosomonas europaea, and a nitrifying mixed–culture have been shown to increase monochloramine demand. Although important, these previous suspended culture batch kinetic experiments were not representative of drinking water distribution systems where bacteria grow predominantly as biofilm attached to pipe walls or sediments and physiological differences may exist between suspension and biofilm growth. Therefore, the current research was an important next step in extending the previous results to investigate monochloramine cometabolism by biofilm grown in annular reactors under drinking water relevant conditions. Estimated monochloramine cometabolism kinetics were similar to those of ammonia metabolism, and monochloramine cometabolism was a significant loss mechanism (25–40% of the observed monochloramine loss). These results demonstrated that monochloramine cometabolism occurred in drinking water relevant nitrifying biofilm; thus, cometabolism may be a significant contribution to monochloramine loss during nitrification episodes in distribution systems. Investigate whether or not nitrifying biofilm can biologically transform monochloramine under drinking water relevant conditions.

  12. Selection of relevant dietary indicators for health.

    Science.gov (United States)

    Steingrímsdóttir, L; Ovesen, L; Moreiras, O; Jacob, S

    2002-05-01

    To define a set of dietary components that are relevant determinants for health in Europe. The selected components are intended to serve as nutrition indicators for health in the European Health Monitoring Programme and, as such, must be limited in number, relevant to health in Europe and practical for all involved countries with respect to data gathering and comparability of data. Major nutrition factors were determined by reviewing relevant epidemiological and clinical literature in nutrition and health as well as referring to reports from international expert groups, including the report from the project Nutrition and Diet for Healthy Lifestyles in Europe. The selection of factors was also based on the relative ease and cost involved for participating countries to obtain comparable and valid data. The selected factors include foods or food groups as well as individual nutrients. Biomarkers are suggested for selected nutrients that pose the greatest difficulty in obtaining valid and comparable data from dietary studies. The following list of diet indicators for health monitoring in Europe was agreed upon by the EFCOSUM group in 2001, in order of priority: vegetables, fruit, bread, fish, saturated fatty acids as percentage of energy (%E), total fat as %E, and ethanol in grams per day. Biomarkers were suggested for the following nutrients: folate, vitamin D, iron, iodine and sodium. Energy has to be assessed in order to calculate %E from total fat and saturated fatty acids.

  13. The value relevance of environmental emissions

    Directory of Open Access Journals (Sweden)

    Melinda Lydia Nelwan

    2016-07-01

    Full Text Available This study examines whether environmental performance has value relevance by investigating the relations between environmental emissions and stock prices for the U.S. public companies. The previous studies argued that the conjectured relations between accounting performance measures and environmental performance do not have a strong theoretical basis, and the modeling of relations between market per-formance measures and environmental performance do not adequately consider the relevance of accounting performance to market value. Therefore, this study examines whether publicly reported environmental emissions provide incremental information to accounting earnings in pricing companies stocks. It is done among the complete set of industries covered by Toxics Release Inventory (TRI reporting for the period 2007 to 2010. Using Ohlson model but modified to include different types of emis-sions, it is found that ground emissions (underground injection and land emissions are value relevant but other emission types (air and water and transferred-out emis-sions appear to not provide incremental information in the valuation model. The result in this study raise concerns that different types of emissions are assessed differently by the market, confirming that studies should not aggregate such measures.

  14. EOG feature relevance determination for microsleep detection

    Directory of Open Access Journals (Sweden)

    Golz Martin

    2017-09-01

    Full Text Available Automatic relevance determination (ARD was applied to two-channel EOG recordings for microsleep event (MSE recognition. 10 s immediately before MSE and also before counterexamples of fatigued, but attentive driving were analysed. Two type of signal features were extracted: the maximum cross correlation (MaxCC and logarithmic power spectral densities (PSD averaged in spectral bands of 0.5 Hz width ranging between 0 and 8 Hz. Generalised learn-ing vector quantisation (GRLVQ was used as ARD method to show the potential of feature reduction. This is compared to support-vector machines (SVM, in which the feature reduction plays a much smaller role. Cross validation yielded mean normalised relevancies of PSD features in the range of 1.6 – 4.9 % and 1.9 – 10.4 % for horizontal and vertical EOG, respectively. MaxCC relevancies were 0.002 – 0.006 % and 0.002 – 0.06 %, respectively. This shows that PSD features of vertical EOG are indispensable, whereas MaxCC can be neglected. Mean classification accuracies were estimated at 86.6±b 1.3 % and 92.3±b 0.2 % for GRLVQ and SVM, respectively. GRLVQ permits objective feature reduction by inclusion of all processing stages, but is not as accurate as SVM.

  15. EOG feature relevance determination for microsleep detection

    Directory of Open Access Journals (Sweden)

    Golz Martin

    2017-09-01

    Full Text Available Automatic relevance determination (ARD was applied to two-channel EOG recordings for microsleep event (MSE recognition. 10 s immediately before MSE and also before counterexamples of fatigued, but attentive driving were analysed. Two type of signal features were extracted: the maximum cross correlation (MaxCC and logarithmic power spectral densities (PSD averaged in spectral bands of 0.5 Hz width ranging between 0 and 8 Hz. Generalised learn-ing vector quantisation (GRLVQ was used as ARD method to show the potential of feature reduction. This is compared to support-vector machines (SVM, in which the feature reduction plays a much smaller role. Cross validation yielded mean normalised relevancies of PSD features in the range of 1.6 - 4.9 % and 1.9 - 10.4 % for horizontal and vertical EOG, respectively. MaxCC relevancies were 0.002 - 0.006 % and 0.002 - 0.06 %, respectively. This shows that PSD features of vertical EOG are indispensable, whereas MaxCC can be neglected. Mean classification accuracies were estimated at 86.6±b 1.3 % and 92.3±b 0.2 % for GRLVQ and SVM, respec-tively. GRLVQ permits objective feature reduction by inclu-sion of all processing stages, but is not as accurate as SVM.

  16. Valerian: No Evidence for Clinically Relevant Interactions

    Directory of Open Access Journals (Sweden)

    Olaf Kelber

    2014-01-01

    Full Text Available In recent popular publications as well as in widely used information websites directed to cancer patients, valerian is claimed to have a potential of adverse interactions with anticancer drugs. This questions its use as a safe replacement for, for example, benzodiazepines. A review on the interaction potential of preparations from valerian root (Valeriana officinalis L. root was therefore conducted. A data base search and search in a clinical drug interaction data base were conducted. Thereafter, a systematic assessment of publications was performed. Seven in vitro studies on six CYP 450 isoenzymes, on p-glycoprotein, and on two UGT isoenzymes were identified. However, the methodological assessment of these studies did not support their suitability for the prediction of clinically relevant interactions. In addition, clinical studies on various valerian preparations did not reveal any relevant interaction potential concerning CYP 1A2, 2D6, 2E1, and 3A4. Available animal and human pharmacodynamic studies did not verify any interaction potential. The interaction potential of valerian preparations therefore seems to be low and thereby without clinical relevance. We conclude that there is no specific evidence questioning their safety, also in cancer patients.

  17. A Survey of Data-Base Information Systems Relevant to Navy Requirements Planning

    Science.gov (United States)

    1983-02-01

    PEG £ COP RFPL ,N IN 51 ir IP c TR PF Ti\\ T T !0 E ro CR c IL: FI p RY Rl D| RE...ACB )FP 1000J 3350 PIB F H DATA SSPEC A S S 2 C ADDI. TXPE CODS C I C C L CUTS 6 VQ 0 0 2 2 2 2 2 2 2 2 2 0 0 0 0 4 2...1311J 019’> 8599 AOB DUU 0 0 OFF nooj 8177 CIV GS-01910-11 A2 2 OFF 13i."J 8177 CI7 GS-01910-n ACB 2 OFF 1000J 3350 PIB 2 r S DATA S B

  18. Seeing is believing: Utilization of subliminal symbols requires a visible relevant context

    NARCIS (Netherlands)

    Gayet, Surya; Van der Stigchel, Stefan; Paffen, Chris L E

    2014-01-01

    Sensory input that is not available for conscious report can still affect our behavior. Recent findings suggest that such subliminal information has the potency to influence behavior in a way that is dependent on the observer's current intentions. Here, we investigate whether conscious observation

  19. Recent trends in epidemiology, sensitization and legal requirements of selected relevant contact allergens

    DEFF Research Database (Denmark)

    Schwensen, Jakob F; Bregnbak, David; Johansen, Jeanne Duus

    2016-01-01

    the last 5 years, a comprehensive review of methylisothiazolinone, chromium, cobalt, rubber accelerators and fragrance ingredients were conducted. Of each allergen we discuss in detail the temporal trend of prevalence, source of exposure, clinical manifestation of allergic contact dermatitis...

  20. The impact of positive, negative and topical relevance feedback

    NARCIS (Netherlands)

    Kaptein, Rianne; Kamps, Jaap; Hiemstra, Djoerd

    2008-01-01

    This document contains a description of experiments for the 2008 Relevance Feedback track. We experiment with different amounts of feedback, including negative relevance feedback. Feedback is implemented using massive weighted query expansion. Parsimonious query expansion using only relevant

  1. International Review of Grid Connection Requirements for Wind Turbines

    Energy Technology Data Exchange (ETDEWEB)

    Jauch, Clemens; Soerensen, Poul [Risoe National Laboratory, Roskilde (Denmark). Wind Energy Dept.; Bak-Jensen, Birgitte [Aalborg Univ. (Denmark). Inst. of Energy Technology

    2004-07-01

    Some of the latest and most relevant grid connection requirements for wind turbines of different countries are summarized and discussed. The inherent implications of these requirements for current wind turbine technology are outlined and discussed.

  2. Identifying Relevant Studies in Software Engineering

    DEFF Research Database (Denmark)

    Zhang, He; Ali Babar, Muhammad; Tell, Paolo

    2011-01-01

    Context: Systematic literature review (SLR) has become an important research methodology in software engineering since the introduction of evidence-based software engineering (EBSE) in 2004. One critical step in applying this methodology is to design and execute appropriate and effective search....... Objective: The main objective of the research reported in this paper is to improve the search step of undertaking SLRs in software engineering (SE) by devising and evaluating systematic and practical approaches to identifying relevant studies in SE. Method: We have systematically selected and analytically...

  3. Happiness: origins, forms, and technical relevance.

    Science.gov (United States)

    Akhtar, Salman

    2010-09-01

    By critically reviewing Freud's views on happiness, and also those of Helene Deutsch, Bertram Lewin, Melanie Klein, and Heinz Kohut, the author evolves a complex and multilayered perspective on the phenomenon. He categorizes happiness into four related and occasionally overlapping varieties: pleasure-based happiness (elation), assertion-based happiness (joy), merger-based happiness (ecstasy), and fulfillment-based happiness (contentment). After entering some caveats and drawing from his clinical experience, the author then demonstrates the relevance of these ideas to the conduct of psychotherapy and psychoanalysis.

  4. Relevance of physics to the pharmacy major.

    Science.gov (United States)

    McCall, Richard P

    2007-08-15

    To offer a physics course that is relevant to pharmacy students, yet still contains many of the fundamental principles of physics. The course was modified over a period of several years to include activities and examples that were related to other courses in the curriculum. Course evaluations were given to assess student attitudes about the importance of physics in the pharmacy curriculum. Students' attitudes have changed over time to appreciate the role that physics plays in their studies. Students gained confidence in their ability to learn in other courses.

  5. Beyond arousal and valence: the importance of the biological versus social relevance of emotional stimuli

    OpenAIRE

    Sakaki, Michiko; Niki, N.; Mather, M.

    2012-01-01

    The present study addressed the hypothesis that emotional stimuli relevant to survival or reproduction (biologically emotional stimuli) automatically affect cognitive processing (e.g., attention, memory), while those relevant to social life (socially emotional stimuli) require elaborative processing to modulate attention and memory. Results of our behavioral studies showed that (1) biologically emotional images hold attention more strongly than do socially emotional images, (2) memory for bio...

  6. Other relevant papers in physical oceanography

    International Nuclear Information System (INIS)

    Nyffeler, F.

    1989-01-01

    During the past few years, significant progress has occurred in the field of physical oceanography partly as a consequence of developing cooperation and international participation in well-coordinated ocean research programmes. Although these programs were not designed specifically to address CRESP problems, many have proved to be directly relevant to CRESP objectives. For example, MODE, POLYMODE, and Tourbillon were intensive site-specific experiments that included studies of dispersion processes throughout the water column. NOAMP and GME were also site specific, involved the entire water column, and even stressed near-bottom and suspended-sediment processes. Others, (e.g., WOCE) are larger in scope and include extensive observations of the general circulation of entire ocean basins. As a whole, they contribute immensely to improving the data base for exchange and transport processes and thereby for the verification and validation of both regional-scale and general-circulation ocean models. That, in turn, is directly relevant to radiological assessments. Selected papers deriving from experiments such as these are discussed and referenced below

  7. [Terbinafine : Relevant drug interactions and their management].

    Science.gov (United States)

    Dürrbeck, A; Nenoff, P

    2016-09-01

    The allylamine terbinafine is the probably most frequently prescribed systemic antifungal agent in Germany for the treatment of dermatomycoses and onychomycoses. According to the German drug law, terbinafine is approved for patients who are 18 years and older; however, this antifungal agent is increasingly used off-label for treatment of onychomycoses and tinea capitis in children. Terbinafine is associated with only a few interactions with other drugs, which is why terbinafine can generally be used without problems in older and multimorbid patients. Nevertheless, some potential interactions of terbinafine with certain drug substances are known, including substances of the group of antidepressants/antipsychotics and some cardiovascular drugs. Decisive for the relevance of interactions is-along with the therapeutic index of the substrate and the possible alternative degradation pathways-the genetically determined type of metabolism. When combining terbinafine with tricyclic antidepressants or selective serotonin reuptake inhibitors and serotonin/noradrenalin reuptake inhibitors, the clinical response and potential side effects must be monitored. Problematic is the use of terbinafine with simultaneous treatment with tamoxifen. The administration of potent CYP2D6 inhibitors leads to a diminished efficacy of tamoxifen because one of its most important active metabolites-endoxifen-is not sufficiently available. Therefore, combination of tamoxifen and terbinafine should be avoided. In conclusion, the number of substances which are able to cause clinically relevant interactions in case of simultaneously administration with terbinafine is clear and should be manageable in the dermatological office with adequate monitoring.

  8. Requirements for quality control of analytical data

    International Nuclear Information System (INIS)

    Westmoreland, R.D.; Bartling, M.H.

    1990-07-01

    The National Contingency Plan (NCP) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) provides procedures for the identification, evaluation, and remediation of past hazardous waste disposal sites. The Hazardous Materials Response section of the NCP consists of several phases: Preliminary Assessment, Site Inspection, Remedial Investigation, Feasibility Study, Remedial Design, and Remedial Action. During any of these phases, analysis of soil, water, and waste samples may be performed. The Hazardous Waste Remedial Actions Program (HAZWRAP) is involved in performing field investigations and sample analyses pursuant to the NCP for the US Department of Energy and other federal agencies. The purpose of this document is to specify the requirements of Martin Marietta Energy Systems, Inc., for the control of accuracy, precision, and completeness of samples and data from the point of collection through analysis. Requirements include data reduction and reporting of resulting environmentally related data. Because every instance and concern may not be addressed in this document, HAZWRAP subcontractors are encouraged to discuss any questions with the Analytical Quality Control Specialist (AQCS) and the HAZWRAP Project Manager. This revision supercedes all other versions of this document

  9. A User-Centered Approach to Adaptive Hypertext Based on an Information Relevance Model

    Science.gov (United States)

    Mathe, Nathalie; Chen, James

    1994-01-01

    Rapid and effective to information in large electronic documentation systems can be facilitated if information relevant in an individual user's content can be automatically supplied to this user. However most of this knowledge on contextual relevance is not found within the contents of documents, it is rather established incrementally by users during information access. We propose a new model for interactively learning contextual relevance during information retrieval, and incrementally adapting retrieved information to individual user profiles. The model, called a relevance network, records the relevance of references based on user feedback for specific queries and user profiles. It also generalizes such knowledge to later derive relevant references for similar queries and profiles. The relevance network lets users filter information by context of relevance. Compared to other approaches, it does not require any prior knowledge nor training. More importantly, our approach to adaptivity is user-centered. It facilitates acceptance and understanding by users by giving them shared control over the adaptation without disturbing their primary task. Users easily control when to adapt and when to use the adapted system. Lastly, the model is independent of the particular application used to access information, and supports sharing of adaptations among users.

  10. Working Toward Policy-Relevant Air Quality Emissions Scenarios

    Science.gov (United States)

    Holloway, T.

    2010-12-01

    Though much work has been done to develop accurate chemical emission inventories, few publicly available inventories are appropriate for realistic policy analysis. Emissions from the electricity and transportation sectors, in particular, respond in complex ways to policy, technology, and energy use change. Many widely used inventories, such as the EPA National Emissions Inventory, are well-suited for modeling current air quality, but do not have the specificity needed to address "what if?" questions. Changes in electricity demand, fuel prices, new power sources, and emission controls all influence the emissions from regional power production, requiring a plant-by-plant assessment to capture the spatially explicit impacts. Similarly, land use, freight distribution, or driving behavior will yield differentiated transportation emissions for urban areas, suburbs, and rural highways. We here present results from three recent research projects at the University of Wisconsin—Madison, where bottom-up emission inventories for electricity, freight transport, and urban vehicle use were constructed to support policy-relevant air quality research. These three studies include: 1) Using the MyPower electricity dispatch model to calculate emissions and air quality impacts of Renewable Portfolio Standards and other carbon-management strategies; 2) Using advanced vehicle and commodity flow data from the Federal Highway Administration to evaluate the potential to shift commodities from truck to rail (assuming expanded infrastructure), and assess a range of alternative fuel suggestions; and 3) Working with urban planners to connect urban density with vehicle use to evaluate the air quality impacts of smart-growth in major Midwest cities. Drawing on the results of these three studies, and on challenges overcome in their execution, we discuss the current state of policy-relevant emission dataset generation, as well as techniques and attributes that need to be further refined in order

  11. THE COMPLEX OF EMOTIONAL EXPERIENCES, RELEVANT MANIFESTATIONS OF INSPIRATION

    Directory of Open Access Journals (Sweden)

    Pavel A. Starikov

    2015-01-01

    Full Text Available The aim of the study is to investigate structure of emotional experiences, relevant manifestations of inspiration creative activities of students.Methods. The proposed methods of mathematical statistics (correlation analysis, factor analysis, multidimensional scaling are applied.Results and scientific novelty. The use of factor analysis, multidimensional scaling allowed to reveal a consistent set of positive experiences of the students, the relevant experience of inspiration in creative activities. «Operational» rueful feelings dedicated by M. Chiksentmihaji («feeling of full involvement, and dilution in what you do», «feeling of concentration, perfect clarity of purpose, complete control and a feeling of total immersion in a job that does not require special efforts» and experiences of the «spiritual» nature, more appropriate to peaks experiences of A. Maslow («feeling of love for all existing, all life»; «a deep sense of self importance, the inner feeling of approval of self»; «feeling of unity with the whole world»; «acute perception of the beauty of the world of nature, “beautiful instant”»; «feeling of lightness, flowing» are included in this complex in accordance with the study results. The interrelation of degree of expressiveness of the given complex of experiences with inspiration experience is considered.Practical significance. The results of the study show structure of emotional experiences, relevant manifestations of inspiration. Research materials can be useful both to psychologists, and experts in the field of pedagogy of creative activity.

  12. Building locally relevant ethics curricula for nursing education in Botswana.

    Science.gov (United States)

    Barchi, F; Kasimatis Singleton, M; Magama, M; Shaibu, S

    2014-12-01

    The goal of this multi-institutional collaboration was to develop an innovative, locally relevant ethics curriculum for nurses in Botswana. Nurses in Botswana face ethical challenges that are compounded by lack of resources, pressures to handle tasks beyond training or professional levels, workplace stress and professional isolation. Capacity to teach nursing ethics in the classroom and in professional practice settings has been limited. A pilot curriculum, including cases set in local contexts, was tested with nursing faculty in Botswana in 2012. Thirty-three per cent of the faculty members indicated they would be more comfortable teaching ethics. A substantial number of faculty members were more likely to introduce the International Council of Nurses Code of Ethics in teaching, practice and mentoring as a result of the training. Based on evaluation data, curricular materials were developed using the Code and the regulatory requirements for nursing practice in Botswana. A web-based repository of sample lectures, discussion cases and evaluation rubrics was created to support the use of the materials. A new master degree course, Nursing Ethics in Practice, has been proposed for fall 2015 at the University of Botswana. The modular nature of the materials and the availability of cases set within the context of clinical nurse practice in Botswana make them readily adaptable to various student academic levels and continuing professional development programmes. The ICN Code of Ethics for Nursing is a valuable teaching tool in developing countries when taught using locally relevant case materials and problem-based teaching methods. The approach used in the development of a locally relevant nursing ethics curriculum in Botswana can serve as a model for nursing education and continuing professional development programmes in other sub-Saharan African countries to enhance use of the ICN Code of Ethics in nursing practice. © 2014 International Council of Nurses.

  13. Hazardous Waste Remedial Actions Program requirements for quality control of analytical data

    International Nuclear Information System (INIS)

    Miller, M.S.; Zolyniak, J.W.

    1988-08-01

    The Hazardous Waste Remedial Action Program (HAZWRAP) is involved in performing field investigations and sample analysis pursuant to the NCP for the Department of Energy and other federal agencies. The purpose of this document is to specify the requirements for the control of the accuracy, precision and completeness of the samples, and data from the point of collection through analysis. The requirements include data reduction and reporting of the resulting environmentally related data. Because every instance and concern may not be addressed in this document, HAZWRAP subcontractors are encouraged to discuss any questions with the HAZWRAP Project Manager hereafter identified as the Project Manager

  14. Constitutional relevance of atomic energy law

    International Nuclear Information System (INIS)

    Lettow, S.

    1980-01-01

    In a decision publicized on December 20, 1979 the German Federal Constitutional Court rejected a claim of unconstitutionality in connection with the licensing procedure of the Muelheim-Kaerlich Nuclear Power Station currently under construction. This constitutes confirmation, by the 1st Department of the Court, of a decision in 1978 by the 2nd Department about the Kalkar fast breeder power plant, in which the peaceful utilization of nuclear energy had been found to be constitutional. However, the new decision by the Federal Constitutional Court particularly emphasizes the constitutional relevance of the rules of procedure under the Atomic Energy Act and their function with respect to the protection of civil rights. (orig.) [de

  15. Mirror neurons and their clinical relevance.

    Science.gov (United States)

    Rizzolatti, Giacomo; Fabbri-Destro, Maddalena; Cattaneo, Luigi

    2009-01-01

    One of the most exciting events in neurosciences over the past few years has been the discovery of a mechanism that unifies action perception and action execution. The essence of this 'mirror' mechanism is as follows: whenever individuals observe an action being done by someone else, a set of neurons that code for that action is activated in the observers' motor system. Since the observers are aware of the outcome of their motor acts, they also understand what the other individual is doing without the need for intermediate cognitive mediation. In this Review, after discussing the most pertinent data concerning the mirror mechanism, we examine the clinical relevance of this mechanism. We first discuss the relationship between mirror mechanism impairment and some core symptoms of autism. We then outline the theoretical principles of neurorehabilitation strategies based on the mirror mechanism. We conclude by examining the relationship between the mirror mechanism and some features of the environmental dependency syndromes.

  16. The Integrin Receptor in Biologically Relevant Bilayers

    DEFF Research Database (Denmark)

    Kalli, Antreas C.; Róg, Tomasz; Vattulainen, Ilpo

    2017-01-01

    /talin complex was inserted in biologically relevant bilayers that resemble the cell plasma membrane containing zwitterionic and charged phospholipids, cholesterol and sphingolipids to study the dynamics of the integrin receptor and its effect on bilayer structure and dynamics. The results of this study...... demonstrate the dynamic nature of the integrin receptor and suggest that the presence of the integrin receptor alters the lipid organization between the two leaflets of the bilayer. In particular, our results suggest elevated density of cholesterol and of phosphatidylserine lipids around the integrin....../talin complex and a slowing down of lipids in an annulus of ~30 Å around the protein due to interactions between the lipids and the integrin/talin F2–F3 complex. This may in part regulate the interactions of integrins with other related proteins or integrin clustering thus facilitating signal transduction...

  17. PREDICTING RELEVANT EMPTY SPOTS IN SOCIAL INTERACTION

    Institute of Scientific and Technical Information of China (English)

    Yoshiharu MAENO; Yukio OHSAWA

    2008-01-01

    An empty spot refers to an empty hard-to-fill space which can be found in the records of the social interaction, and is the clue to the persons in the underlying social network who do not appear in the records. This contribution addresses a problem to predict relevant empty spots in social interaction. Homogeneous and inhomogeneous networks are studied as a model underlying the social interaction. A heuristic predictor function method is presented as a new method to address the problem. Simulation experiment is demonstrated over a homogeneous network. A test data set in the form of market baskets is generated from the simulated communication. Precision to predict the empty spots is calculated to demonstrate the performance of the presented method.

  18. Mathematical Properties Relevant to Geomagnetic Field Modeling

    DEFF Research Database (Denmark)

    Sabaka, Terence J.; Hulot, Gauthier; Olsen, Nils

    2010-01-01

    be directly measured. In this chapter, the mathematical foundation of global (as opposed to regional) geomagnetic field modeling is reviewed, and the spatial modeling of the field in spherical coordinates is focussed. Time can be dealt with as an independent variable and is not explicitly considered......Geomagnetic field modeling consists in converting large numbers of magnetic observations into a linear combination of elementary mathematical functions that best describes those observations.The set of numerical coefficients defining this linear combination is then what one refers.......The relevant elementary mathematical functions are introduced, their properties are reviewed, and how they can be used to describe the magnetic field in a source-free (such as the Earth’s neutral atmosphere) or source-dense (such as the ionosphere) environment is explained. Completeness and uniqueness...

  19. Mathematical Properties Relevant to Geomagnetic Field Modeling

    DEFF Research Database (Denmark)

    Sabaka, Terence J.; Hulot, Gauthier; Olsen, Nils

    2014-01-01

    be directly measured. In this chapter, the mathematical foundation of global (as opposed to regional) geomagnetic field modeling is reviewed, and the spatial modeling of the field in spherical coordinates is focused. Time can be dealt with as an independent variable and is not explicitly considered......Geomagnetic field modeling consists in converting large numbers of magnetic observations into a linear combination of elementary mathematical functions that best describes those observations. The set of numerical coefficients defining this linear combination is then what one refers....... The relevant elementary mathematical functions are introduced, their properties are reviewed, and how they can be used to describe the magnetic field in a source-free (such as the Earth’s neutral atmosphere) or source-dense (such as the ionosphere) environment is explained. Completeness and uniqueness...

  20. Towards increased policy relevance in energy modeling

    Energy Technology Data Exchange (ETDEWEB)

    Worrell, Ernst; Ramesohl, Stephan; Boyd, Gale

    2003-07-29

    Historically, most energy models were reasonably equipped to assess the impact of a subsidy or change in taxation, but are often insufficient to assess the impact of more innovative policy instruments. We evaluate the models used to assess future energy use, focusing on industrial energy use. We explore approaches to engineering-economic analysis that could help improve the realism and policy relevance of engineering-economic modeling frameworks. We also explore solutions to strengthen the policy usefulness of engineering-economic analysis that can be built from a framework of multi-disciplinary cooperation. We focus on the so-called ''engineering-economic'' (or ''bottom-up'') models, as they include the amount of detail that is commonly needed to model policy scenarios. We identify research priorities for the modeling framework, technology representation in models, policy evaluation and modeling of decision-making behavior.

  1. Climate-relevant monitorings in Germany

    International Nuclear Information System (INIS)

    Metternich, P.

    1993-01-01

    This catalogue contains so-called meta-data; i.e. information on data. For each measuring programme or set of data, users find the address (postal address, telephone, fax-number) of the respective contact person at the beginning of the entry. The catalogue has three parts: Part A is a compilation of monitoring programmes using conventional methods adopted on the ground. Part B contains research programmes or sets of data from the field of remote sensing. In part C, data sets from time series of climate-relevant parameters are described. Section A was additionally structured according so the compartments of the climate system: Atmosphere, hydrosphere, cryosphere, biosphere. (orig./KW) [de

  2. Bacteriophage lambda: early pioneer and still relevant

    Science.gov (United States)

    Casjens, Sherwood R.; Hendrix, Roger W.

    2015-01-01

    Molecular genetic research on bacteriophage lambda carried out during its golden age from the mid 1950's to mid 1980's was critically important in the attainment of our current understanding of the sophisticated and complex mechanisms by which the expression of genes is controlled, of DNA virus assembly and of the molecular nature of lysogeny. The development of molecular cloning techniques, ironically instigated largely by phage lambda researchers, allowed many phage workers to switch their efforts to other biological systems. Nonetheless, since that time the ongoing study of lambda and its relatives have continued to give important new insights. In this review we give some relevant early history and describe recent developments in understanding the molecular biology of lambda's life cycle. PMID:25742714

  3. Reach and Relevance of Prison Research

    Directory of Open Access Journals (Sweden)

    Hilde Tubex

    2015-04-01

    Full Text Available In this contribution I reflect on the changes in the penal landscape and how they impact on prison research. I do this from my experiences as a prison researcher in a variety of roles, in both Europe and Australia. The growing dominance of managerialism has impacted on both corrective services and universities, in ways that have changed the relationship between current prison practices and academically oriented research. Therefore, academics have to question how their contemporary prison research can bridge the emerging gap: how they can not only produce research that adheres to the roots of criminology and provides a base for a rational penal policy, but also how they can develop strategies to get recognition of and funding for this broader contextual work which, although it might not produce results that are immediately identifiable, can be of relevance in indirect ways and in the longer term.

  4. Relevance of protection quantities in medical exposures

    International Nuclear Information System (INIS)

    Pradhan, A.S.

    2008-01-01

    International Commission on Radiological Protection (ICRP) continues to classify the exposures to radiation in three categories; namely 1- occupational exposure, 2- public exposure, and 3- medical exposure. Protection quantities are primarily meant for the regulatory purpose in radiological protection for controlling and limiting stochastic risks in occupational and public exposures. These are based on two basic assumptions of 1- linear no-threshold dose-effect relationship (LNT) at low doses and 2- long-term additivity of low doses. Medical exposure are predominantly delivered to individuals (patients) undergoing diagnostic examinations, interventional procedures and radiation therapy but also include individual caring for or comforting patients incurring exposure and the volunteers of biomedical medical research programmes. Radiation protection is as relevant to occupational and public exposure as to medical exposures except that the dose limits set for the formers are not applicable to medical exposure but reference levels and dose constrains are recommended for diagnostic and interventional medical procedures. In medical institutions, both the occupational and medical exposure takes place. Since the doses in diagnostic examinations are low, it has been observed that not only the protection quantities are often used in such cases but these are extended to estimate the number of cancer deaths due to such practices. One of the striking features of the new ICRP recommendations has been to elaborate the concepts of the dosimetric quantities. The limitation of protection quantities ((Effective dose, E=Σ RT D TR .W T .W R and Equivalent Dose H T =Σ RT D TR .W R ) have been brought out and this has raised a great concern and initiated debates on the use of these quantities in medical exposures. Consequently, ICRP has set a task group to provide more details and the recommendations. It has, therefore, became important to draw the attention of medical physics community

  5. Ecological principles relevant to nuclear war

    International Nuclear Information System (INIS)

    Hutchinson, T.C.; Cropper, W.P. Jr.; Grover, H.D.

    1985-01-01

    The ecological principles outlined are very basic ones; the authors anticipate a readership trained in a broad range of disciplines, including those unfamiliar with the academic discipline of ecology. The authors include substantial discussion on ecophysiology (i.e., the responses of organisms to their environment) because this is relevant to the new understanding of the potential climatic consequences of nuclear war. In particular, the physiological sensitivity of organisms to reduced levels of light and temperature are a key part of the analysis of the potential ecological effects and agricultural effects of nuclear war. Much of the ecological analysis has been organized around major biological units called biomes. The authors describe the biome concept and discuss some of the environmental-climatic factors that are believed to control biome distribution. Emphasis is given to plants because of their controlling influence on ecosystem functions through their role as primary producers. Future reports are needed to address more fully the potential effects on animals. Much more research needs to be done on both plant and animal responses to the types of perturbations possible for the aftermath of a nuclear war. Another important element for analysis of the potential ecological consequences of nuclear war concerns recovery processes. As the post-nuclear war environmental extremes ameliorate, ecological communities in devastated regions would begin to reorganize. It is not possible to predict the course of such a succession precisely, but some principles concerning post-perturbation replacement (such as seed banks and germination), relevant successional patterns, and organism strategies are discussed

  6. Management of work-relevant upper limb disorders: a review.

    Science.gov (United States)

    Burton, A Kim; Kendall, Nicholas A S; Pearce, Brian G; Birrell, Lisa N; Bainbridge, L Christopher

    2009-01-01

    Upper limb disorders (ULDs) are clinically challenging and responsible for considerable work loss. There is a need to determine effective approaches for their management. To determine evidence-based management strategies for work-relevant ULDs and explore whether a biopsychosocial approach is appropriate. Literature review using a best evidence synthesis. Data from articles identified through systematic searching of electronic databases and citation tracking were extracted into evidence tables. The information was synthesized into high-level evidence statements, which were ordered into themes covering classification/diagnosis, epidemiology, associations/risks and management/treatment, focusing on return to work or work retention and taking account of distinctions between non-specific complaints and specific diagnoses. Neither biomedical treatment nor ergonomic workplace interventions alone offer an optimal solution; rather, multimodal interventions show considerable promise, particularly for occupational outcomes. Early return to work, or work retention, is an important goal for most cases and may be facilitated, where necessary, by transitional work arrangements. The emergent evidence indicates that successful management strategies require all the players to be on side and acting in a coordinated fashion; this requires engaging employers and workers to participate. The biopsychosocial model applies: biological considerations should not be ignored, but psychosocial factors are more influential for occupational outcomes. Implementation of interventions that address the full range of psychosocial issues will require a cultural shift in the way the relationship between upper limb complaints and work is conceived and handled. Dissemination of evidence-based messages can contribute to the needed cultural shift.

  7. Functional relevance of water and glycerol channels in Saccharomyces cerevisiae.

    Science.gov (United States)

    Sabir, Farzana; Loureiro-Dias, Maria C; Soveral, Graça; Prista, Catarina

    2017-05-01

    Our understanding of the functional relevance of orthodox aquaporins and aquaglyceroporins in Saccharomyces cerevisiae is essentially based on phenotypic variations obtained by expression/overexpression/deletion of these major intrinsic proteins in selected strains. These water/glycerol channels are considered crucial during various life-cycle phases, such as sporulation and mating and in some life processes such as rapid freeze-thaw tolerance, osmoregulation and phenomena associated with cell surface. Despite their putative functional roles not only as channels but also as sensors, their underlying mechanisms and their regulation are still poorly understood. In the present review, we summarize and discuss the physiological relevance of S. cerevisiae aquaporins (Aqy1 and Aqy2) and aquaglyceroporins (Fps1 and Yfl054c). In particular, the fact that most S. cerevisiae laboratory strains harbor genes coding for non-functional aquaporins, while wild and industrial strains possess at least one functional aquaporin, suggests that aquaporin activity is required for cell survival under more harsh conditions. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. THE RELEVANCE OF MANAGEMENT ACCOUNTING FOR THE HOSPITALITY INDUSTRY

    Directory of Open Access Journals (Sweden)

    Briciu Sorin

    2012-07-01

    Full Text Available In the contemporary period the tourism and hospitality industry has experienced dynamic growth despite the challenges facing not only the global crisis, but also market changes, consumer behavior and technological trends. Accounting, the language of business is required to keep up with changes made to each particular area of activity so that they can provide timely relevant information to be managed by an efficient information system. Our article focuses on presenting the importance of management accounting and cost information system in the hospitality industry, then consider identifying features of this sector and their impact on accounting. The methodology of our research falls within the economic research, being theoretical, aiming primarily to knowledge objectives and the relevance of management accounting for economic entities, and then we have the characteristics of hospitality industry and possible organizational management accounting in this sector. In our perspective cost calculation for services, packages or travel benefits must take into account the development of the accounts from Class 9, so we propose a possible method to customize them according to the Direct Costing and CVP analysis. Our research will also be explanatory descriptive, trying to answer the questions How? and Why?

  9. Interaction of dermatologically relevant nanoparticles with skin cells and skin

    Directory of Open Access Journals (Sweden)

    Annika Vogt

    2014-12-01

    Full Text Available The investigation of nanoparticle interactions with tissues is complex. High levels of standardization, ideally testing of different material types in the same biological model, and combinations of sensitive imaging and detection methods are required. Here, we present our studies on nanoparticle interactions with skin, skin cells, and biological media. Silica, titanium dioxide and silver particles were chosen as representative examples for different types of skin exposure to nanomaterials, e.g., unintended environmental exposure (silica versus intended exposure through application of sunscreen (titanium dioxide or antiseptics (silver. Because each particle type exhibits specific physicochemical properties, we were able to apply different combinations of methods to examine skin penetration and cellular uptake, including optical microscopy, electron microscopy, X-ray microscopy on cells and tissue sections, flow cytometry of isolated skin cells as well as Raman microscopy on whole tissue blocks. In order to assess the biological relevance of such findings, cell viability and free radical production were monitored on cells and in whole tissue samples. The combination of technologies and the joint discussion of results enabled us to look at nanoparticle–skin interactions and the biological relevance of our findings from different angles.

  10. [Differences between generations: relevant for medical education in the Netherlands].

    Science.gov (United States)

    Busari, Jamiu O; Scheele, Fedde

    2015-01-01

    Provision of care is increasingly being tailored to patients' wishes, which means that insight into the ideas, norms and values of the care-consumer are required. This approach is also beginning to filter through into medical education. We can differentiate generations on the basis of shared opinions, because groups with shared experiences usually share the same values. This is a useful line of approach if we wish to serve different generations of consumers better. At the moment there are four different generations influencing the setup and division of the healthcare services and relevant to medical education in the coming decades. Future education methods will have to be in line with the wishes of the generation from which new doctors come. In order to achieve better care for patients it is important to give 'thinking in generations' more attention in medical education.

  11. Developing independent investigators for clinical research relevant for Africa

    LENUS (Irish Health Repository)

    Manabe, Yukari C

    2011-12-29

    Abstract Sustainable research capacity building requires training individuals at multiple levels within a supportive institutional infrastructure to develop a critical mass of independent researchers. At many African medical institutions, a PhD is important for academic promotion and is, therefore, an important focal area for capacity building programs. We examine the training at the Infectious Diseases Institute (IDI) as a model for in-country training based on systems capacity building and attention to the academic environment. PhD training in Africa should provide a strong research foundation for individuals to perform independent, original research and to mentor others. Training the next generation of researchers within excellent indigenous academic centers of excellence with strong institutional infrastructure will empower trainees to ask regionally relevant research questions that will benefit Africans.

  12. Mild obstructive sleep apnoea: clinical relevance and approaches to management.

    Science.gov (United States)

    McNicholas, Walter T; Bonsignore, Maria R; Lévy, Patrick; Ryan, Silke

    2016-10-01

    Obstructive sleep apnoea is highly prevalent in the general population worldwide, especially in its mild form. Clinical manifestations correlate poorly with disease severity measured by the apnoea-hypopnoea index (AHI), which complicates diagnosis. Full polysomnography might be more appropriate to assess suspected mild cases because limited ambulatory diagnostic systems are least accurate in mild disease. Treatment options in mild obstructive sleep apnoea include continuous positive airway pressure (CPAP) and oral appliance therapy, in addition to positional therapy and weight reduction when appropriate. The superior efficacy of CPAP in reducing AHI is offset by greater tolerance of oral appliances, especially in mild disease. Although severe obstructive sleep apnoea is associated with adverse health consequences, including cardiometabolic comorbidities, the association with mild disease is unclear, and reports differ regarding the clinical relevance of mild obstructive sleep apnoea. Improved diagnostic techniques and evidence-based approaches to management in mild obstructive sleep apnoea require further research. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. The functional relevance of polyploidization in the skin.

    Science.gov (United States)

    Trakala, Marianna; Malumbres, Marcos

    2014-02-01

    Cell proliferation and differentiation are tightly coupled through the regulation of the cell division cycle. To preserve specific functional properties in differentiated cells, distinct variants of the basic mitotic cell cycle are used in various mammalian tissues, leading to the formation of polyploid cells. In this issue of Experimental Dermatology, Gandarillas and Freije discuss the evidences for polyploidization in keratinocytes, a process whose physiological relevance is now becoming evident. A better evaluation of these unconventional cell cycles is required not only to improve our understanding of the development and structure of the epidermis but also for future therapies against skin diseases. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. The qualification of electrical components and instrumentations relevant to safety

    CERN Document Server

    Zambardi, F

    1989-01-01

    Systems and components relevant to safety of nuclear power plants must maintain their functional integrity in order to assure accident prevention and mitigation. Redundancy is utilized against random failures, nevertheless care must be taken to avoid common failures in redundant components. Main sources of degradation and common cause failures consist in the aging effects and in the changes of environmental conditions which occur during the plant life and the postulated accidents. These causes of degradation are expected to be especially significant for instrumentation and electrical equipment, which can have a primary role in safety systems. The qualification is the methodology by which component safety requirements can be met against the above mentioned causes of degradation. In this report the connection between the possible, plant conditions and the resulting degradation effects on components is preliminarily addressed. A general characterization of the qualification is then presented. Basis, methods and ...

  15. Scientific opinion on the safety of proline-specific oligopeptidase as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    2017-01-01

    and of the Council, taking into account the comments and objections of a scientific nature raised by Member States. The novel food is an enzyme preparation of prolyl-oligopeptidase produced with a genetically modified Aspergillus niger self clone strain. The target population is the general adult population......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on proline-specific oligopeptidase (Tolerase® G) as a novel food ingredient submitted pursuant to Regulation (EC) No 258/97 of the European Parliament...

  16. Modularization--A Road to Relevance?

    Science.gov (United States)

    Palow, William P.

    This paper describes a modular program at a community college for instructing non-science majors in college algebra. The two-course sequence is comprised of four modules each and successful completion of a module is required before a student proceeds to the next. Placement, grading policies, and scheduling are all discussed. A formative evaluation…

  17. Increasing Access and Relevance in Distance Education

    Science.gov (United States)

    Mendenhall, Robert W.

    2009-01-01

    Access to higher education is subject to many factors including affordability, time and geography. Distance education can deliver education to those that live far from a campus. Some of that distance education may be synchronous, or live, requiring students to be available at certain times. Flexibility and access are increased when the instruction…

  18. [Relevance of big data for molecular diagnostics].

    Science.gov (United States)

    Bonin-Andresen, M; Smiljanovic, B; Stuhlmüller, B; Sörensen, T; Grützkau, A; Häupl, T

    2018-04-01

    Big data analysis raises the expectation that computerized algorithms may extract new knowledge from otherwise unmanageable vast data sets. What are the algorithms behind the big data discussion? In principle, high throughput technologies in molecular research already introduced big data and the development and application of analysis tools into the field of rheumatology some 15 years ago. This includes especially omics technologies, such as genomics, transcriptomics and cytomics. Some basic methods of data analysis are provided along with the technology, however, functional analysis and interpretation requires adaptation of existing or development of new software tools. For these steps, structuring and evaluating according to the biological context is extremely important and not only a mathematical problem. This aspect has to be considered much more for molecular big data than for those analyzed in health economy or epidemiology. Molecular data are structured in a first order determined by the applied technology and present quantitative characteristics that follow the principles of their biological nature. These biological dependencies have to be integrated into software solutions, which may require networks of molecular big data of the same or even different technologies in order to achieve cross-technology confirmation. More and more extensive recording of molecular processes also in individual patients are generating personal big data and require new strategies for management in order to develop data-driven individualized interpretation concepts. With this perspective in mind, translation of information derived from molecular big data will also require new specifications for education and professional competence.

  19. Functionally relevant microsatellites in sugarcane unigenes

    Directory of Open Access Journals (Sweden)

    Singh Nagendra K

    2010-11-01

    Full Text Available Abstract Background Unigene sequences constitute a rich source of functionally relevant microsatellites. The present study was undertaken to mine the microsatellites in the available unigene sequences of sugarcane for understanding their constitution in the expressed genic component of its complex polyploid/aneuploid genome, assessing their functional significance in silico, determining the extent of allelic diversity at the microsatellite loci and for evaluating their utility in large-scale genotyping applications in sugarcane. Results The average frequency of perfect microsatellite was 1/10.9 kb, while it was 1/44.3 kb for the long and hypervariable class I repeats. GC-rich trinucleotides coding for alanine and the GA-rich dinucleotides were the most abundant microsatellite classes. Out of 15,594 unigenes mined in the study, 767 contained microsatellite repeats and for 672 of these putative functions were determined in silico. The microsatellite repeats were found in the functional domains of proteins encoded by 364 unigenes. Its significance was assessed by establishing the structure-function relationship for the beta-amylase and protein kinase encoding unigenes having repeats in the catalytic domains. A total of 726 allelic variants (7.42 alleles per locus with different repeat lengths were captured precisely for a set of 47 fluorescent dye labeled primers in 36 sugarcane genotypes and five cereal species using the automated fragment analysis system, which suggested the utility of designed primers for rapid, large-scale and high-throughput genotyping applications in sugarcane. Pair-wise similarity ranging from 0.33 to 0.84 with an average of 0.40 revealed a broad genetic base of the Indian varieties in respect of functionally relevant regions of the large and complex sugarcane genome. Conclusion Microsatellite repeats were present in 4.92% of sugarcane unigenes, for most (87.6% of which functions were determined in silico. High level of

  20. Early onset depression: the relevance of anxiety.

    Science.gov (United States)

    Parker, G; Wilhelm, K; Asghari, A

    1997-01-01

    The aim of this study was to determine risk factors that may differentiate early onset from late onset depression. A non-clinical cohort that had been assessed from 1978 to 1993 at 5 yearly intervals and that had a high prevalence rate of lifetime depression took part in the study. We established an appropriate age cut-off to distinguish early onset (i.e. before 26 years) of major and of minor depression, and examined the relevance of a number of possible determinants of early onset depression assessed over the life of the study. Despite several dimensional measures of depression, self-esteem and personality being considered, they generally failed (when assessed early in the study) to discriminate subsequent early onset depression, with the exception of low masculinity scores being a weak predictor of major and/or minor depression. Early onset depression was strongly predicted, however, by a lifetime episode of a major anxiety disorder, with generalised anxiety being a somewhat stronger and more consistent predictor than panic disorder, agoraphobia and minor anxiety disorders (ie social phobia, simple phobia). The possibility that anxiety may act as a key predispositional factor to early onset depression and to a greater number of depressive episodes is important in that clinical assessment and treatment of any existing anxiety disorder may be a more efficient and useful strategy than focussing primarily on the depressive disorder.

  1. Top studies relevant to primary care practice.

    Science.gov (United States)

    Perry, Danielle; Kolber, Michael R; Korownyk, Christina; Lindblad, Adrienne J; Ramji, Jamil; Ton, Joey; Allan, G Michael

    2018-04-01

    To summarize 10 high-quality studies from 2017 that have strong relevance to primary care practice. Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching the American College of Physicians Journal Club. Topics of the 2017 articles include whether treating subclinical hypothyroidism improves outcomes or symptoms; whether evolocumab reduces cardiovascular disease as well as low-density lipoprotein levels; whether lifestyle interventions reduce medication use in patients with diabetes; whether vitamin D prevents cardiovascular disease, cancer, or upper respiratory tract infections; whether canagliflozin reduces clinical events in patients with diabetes; how corticosteroid injections affect knee osteoarthritis; whether drained abscesses benefit from antibiotic treatment; whether patients with diabetes benefit from bariatric surgery; whether exenatide reduces clinical events in patients with diabetes; and whether tympanostomy tubes affect outcomes in recurrent acute otitis media or chronic otitis media. We provide brief summaries, context where needed, and final recommendations for 10 studies with potential effects on primary care. We also briefly review 5 "runner-up" studies. Research from 2017 produced several high-quality studies in diabetes management. These have demonstrated benefit for alternative therapies and offered evidence not previously available. This year's selection of studies also provided information on a variety of conditions and therapies that are, or might become, more common in primary care settings. Copyright© the College of Family Physicians of Canada.

  2. Clinically Relevant Anticancer Polymer Paclitaxel Therapeutics

    Directory of Open Access Journals (Sweden)

    Danbo Yang

    2010-12-01

    Full Text Available The concept of utilizing polymers in drug delivery has been extensively explored for improving the therapeutic index of small molecule drugs. In general, polymers can be used as polymer-drug conjugates or polymeric micelles. Each unique application mandates its own chemistry and controlled release of active drugs. Each polymer exhibits its own intrinsic issues providing the advantage of flexibility. However, none have as yet been approved by the U.S. Food and Drug Administration. General aspects of polymer and nano-particle therapeutics have been reviewed. Here we focus this review on specific clinically relevant anticancer polymer paclitaxel therapeutics. We emphasize their chemistry and formulation, in vitro activity on some human cancer cell lines, plasma pharmacokinetics and tumor accumulation, in vivo efficacy, and clinical outcomes. Furthermore, we include a short review of our recent developments of a novel poly(L-g-glutamylglutamine-paclitaxel nano-conjugate (PGG-PTX. PGG-PTX has its own unique property of forming nano-particles. It has also been shown to possess a favorable profile of pharmacokinetics and to exhibit efficacious potency. This review might shed light on designing new and better polymer paclitaxel therapeutics for potential anticancer applications in the clinic.

  3. Ligand Exchange Kinetics of Environmentally Relevant Metals

    Energy Technology Data Exchange (ETDEWEB)

    Panasci, Adele Frances [Univ. of California, Davis, CA (United States)

    2014-07-15

    The interactions of ground water with minerals and contaminants are of broad interest for geochemists but are not well understood. Experiments on the molecular scale can determine reaction parameters (i.e. rates of ligand exchange, activation entropy, activation entropy, and activation volume) that can be used in computations to gain insight into reactions that occur in natural groundwaters. Experiments to determine the rate of isotopic ligand exchange for three environmentally relevant metals, rhodium (Rh), iron (Fe), and neptunium (Np), are described. Many environmental transformations of metals (e.g. reduction) in soil occur at trivalent centers, Fe(III) in particular. Contaminant ions absorb to mineral surfaces via ligand exchange, and the reversal of this reaction can be dangerous, releasing contaminants into the environment. Ferric iron is difficult to study spectroscopically because most of its complexes are paramagnetic and are generally reactive toward ligand exchange; therefore, Rh(III), which is diamagnetic and less reactive, was used to study substitution reactions that are analogous to those that occur on mineral oxide surfaces. Studies on both Np(V) and Np(VI) are important in their own right, as 237Np is a radioactive transuranic element with a half-life of 2 million years.

  4. Relevance of extracellular DNA in rhizosphere

    Science.gov (United States)

    Pietramellara, Giacomo; Ascher, Judith; Baraniya, Divyashri; Arfaioli, Paola; Ceccherini, Maria Teresa; Hawes, Martha

    2013-04-01

    One of the most promising areas for future development is the manipulation of the rhizosphere to produce sustainable and efficient agriculture production systems. Using Omics approaches, to define the distinctive features of eDNA systems and structures, will facilitate progress in rhizo-enforcement and biocontrol studies. The relevance of these studies results clear when we consider the plethora of ecological functions in which eDNA is involved. This fraction can be actively extruded by living cells or discharged during cellular lysis and may exert a key role in the stability and variability of the soil bacterial genome, resulting also a source of nitrogen and phosphorus for plants due to the root's capacity to directly uptake short DNA fragments. The adhesive properties of the DNA molecule confer to eDNA the capacity to inhibit or kill pathogenic bacteria by cation limitation induction, and to facilitate formation of biofilm and extracellular traps (ETs), that may protect microorganisms inhabiting biofilm and plant roots against pathogens and allelopathic substances. The ETs are actively extruded by root border cells when they are dispersed in the rhizosphere, conferring to plants the capacity to extend an endogenous pathogen defence system outside the organism. Moreover, eDNA could be involved in rhizoremediation in heavy metal polluted soil acting as a bioflotation reagent.

  5. Relevance of tidal heating on large TNOs

    Science.gov (United States)

    Saxena, Prabal; Renaud, Joe P.; Henning, Wade G.; Jutzi, Martin; Hurford, Terry

    2018-03-01

    We examine the relevance of tidal heating for large Trans-Neptunian Objects, with a focus on its potential to melt and maintain layers of subsurface liquid water. Depending on their past orbital evolution, tidal heating may be an important part of the heat budget for a number of discovered and hypothetical TNO systems and may enable formation of, and increased access to, subsurface liquid water. Tidal heating induced by the process of despinning is found to be particularly able to compete with heating due to radionuclide decay in a number of different scenarios. In cases where radiogenic heating alone may establish subsurface conditions for liquid water, we focus on the extent by which tidal activity lifts the depth of such conditions closer to the surface. While it is common for strong tidal heating and long lived tides to be mutually exclusive, we find this is not always the case, and highlight when these two traits occur together. We find cases where TNO systems experience tidal heating that is a significant proportion of, or greater than radiogenic heating for periods ranging from100‧s of millions to a billion years. For subsurface oceans that contain a small antifreeze component, tidal heating due to very high initial spin states may enable liquid water to be preserved right up to the present day. Of particular interest is the Eris-Dysnomia system, which in those cases may exhibit extant cryovolcanism.

  6. Extracellular vesicles: fundamentals and clinical relevance

    Directory of Open Access Journals (Sweden)

    Wael Nassar

    2015-01-01

    Full Text Available All types of cells of eukaryotic organisms produce and release small nanovesicles into their extracellular environment. Early studies have described these vesicles as ′garbage bags′ only to remove obsolete cellular molecules. Valadi and colleagues, in 2007, were the first to discover the capability of circulating extracellular vesicles (EVs to horizontally transfer functioning gene information between cells. These extracellular vesicles express components responsible for angiogenesis promotion, stromal remodeling, chemoresistance, genetic exchange, and signaling pathway activation through growth factor/receptor transfer. EVs represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins, lipids, signaling proteins, and RNAs. They contribute to physiology and pathology, and they have a myriad of potential clinical applications in health and disease. Moreover, vesicles can pass the blood-brain barrier and may perhaps even be considered as naturally occurring liposomes. These cell-derived EVs not only represent a central mediator of the disease microenvironment, but their presence in the peripheral circulation may serve as a surrogate for disease biopsies, enabling real-time diagnosis and disease monitoring. In this review, we′ll be addressing the characteristics of different types of extracellular EVs, as well as their clinical relevance and potential as diagnostic markers, and also define therapeutic options.

  7. Human error theory: relevance to nurse management.

    Science.gov (United States)

    Armitage, Gerry

    2009-03-01

    Describe, discuss and critically appraise human error theory and consider its relevance for nurse managers. Healthcare errors are a persistent threat to patient safety. Effective risk management and clinical governance depends on understanding the nature of error. This paper draws upon a wide literature from published works, largely from the field of cognitive psychology and human factors. Although the content of this paper is pertinent to any healthcare professional; it is written primarily for nurse managers. Error is inevitable. Causation is often attributed to individuals, yet causation in complex environments such as healthcare is predominantly multi-factorial. Individual performance is affected by the tendency to develop prepacked solutions and attention deficits, which can in turn be related to local conditions and systems or latent failures. Blame is often inappropriate. Defences should be constructed in the light of these considerations and to promote error wisdom and organizational resilience. Managing and learning from error is seen as a priority in the British National Health Service (NHS), this can be better achieved with an understanding of the roots, nature and consequences of error. Such an understanding can provide a helpful framework for a range of risk management activities.

  8. Clinically Relevant Anticancer Polymer Paclitaxel Therapeutics

    International Nuclear Information System (INIS)

    Yang, Danbo; Yu, Lei; Van, Sang

    2010-01-01

    The concept of utilizing polymers in drug delivery has been extensively explored for improving the therapeutic index of small molecule drugs. In general, polymers can be used as polymer-drug conjugates or polymeric micelles. Each unique application mandates its own chemistry and controlled release of active drugs. Each polymer exhibits its own intrinsic issues providing the advantage of flexibility. However, none have as yet been approved by the U.S. Food and Drug Administration. General aspects of polymer and nano-particle therapeutics have been reviewed. Here we focus this review on specific clinically relevant anticancer polymer paclitaxel therapeutics. We emphasize their chemistry and formulation, in vitro activity on some human cancer cell lines, plasma pharmacokinetics and tumor accumulation, in vivo efficacy, and clinical outcomes. Furthermore, we include a short review of our recent developments of a novel poly(l-γ-glutamylglutamine)-paclitaxel nano-conjugate (PGG-PTX). PGG-PTX has its own unique property of forming nano-particles. It has also been shown to possess a favorable profile of pharmacokinetics and to exhibit efficacious potency. This review might shed light on designing new and better polymer paclitaxel therapeutics for potential anticancer applications in the clinic

  9. Accreditation - Its relevance for laboratories measuring radionuclides

    Energy Technology Data Exchange (ETDEWEB)

    Palsson, S E [Icelandic Radiation Protection Inst. (Iceland)

    2001-11-01

    Accreditation is an internationally recognised way for laboratories to demonstrate their competence. Obtaining and maintaining accreditation is, however, a costly and time-consuming procedure. The benefits of accreditation also depend on the role of the laboratory. Accreditation may be of limited relevance for a research laboratory, but essential for a laboratory associated with a national authority and e.g. issuing certificates. This report describes work done within the NKSBOK-1.1 sub-project on introducing accreditation to Nordic laboratories measuring radionuclides. Initially the focus was on the new standard ISO/IEC 17025, which was just in a draft form at the time, but which provides now a new framework for accreditation of laboratories. Later the focus was widened to include a general introduction to accreditation and providing through seminars a forum for exchanging views on the experience laboratories have had in this field. Copies of overheads from the last such seminar are included in the appendix to this report. (au)

  10. Perspective: Organizational professionalism: relevant competencies and behaviors.

    Science.gov (United States)

    Egener, Barry; McDonald, Walter; Rosof, Bernard; Gullen, David

    2012-05-01

    The professionalism behaviors of physicians have been extensively discussed and defined; however, the professionalism behaviors of health care organizations have not been systemically categorized or described. Defining organizational professionalism is important because the behaviors of a health care organization may substantially impact the behaviors of physicians and others within the organization as well as other institutions and the larger community. In this article, the authors discuss the following competencies of organizational professionalism, derived from ethical values: service, respect, fairness, integrity, accountability, mindfulness, and self-motivation. How nonprofit health care organizations can translate these competencies into behaviors is described. For example, incorporating metrics of population health into assessments of corporate success may increase collaboration among regional health care organizations while also benefiting the community. The unique responsibilities of leadership to model these competencies, promote them in the community, and develop relevant organizational strategies are clarified. These obligations elevate the importance of the executive leadership's capacity for self-reflection and the governing boards' responsibility for mapping operational activities to organizational mission. Lastly, the authors consider how medical organizations are currently addressing professionalism challenges. In an environment made turbulent by regulatory change and financial constraints, achieving proficiency in professionalism competencies can assist nonprofit health care organizations to promote population health and the well-being of their workforces.

  11. Media and mental illness: Relevance to India

    Directory of Open Access Journals (Sweden)

    S K Padhy

    2014-01-01

    Full Text Available Media has a complex interrelationship with mental illnesses. This narrative review takes a look at the various ways in which media and mental illnesses interact. Relevant scientific literature and electronic databases were searched, including Pubmed and GoogleScholar, to identify studies, viewpoints and recommendations using keywords related to media and mental illnesses. This review discusses both the positive and the negative portrayals of mental illnesses through the media. The portrayal of mental health professionals and psychiatric treatment is also discussed. The theories explaining the relationship of how media influences the attitudes and behavior are discussed. Media has also been suggested to be a risk factor for the genesis or exacerbation of mental illnesses like eating disorders and substance use disorders. The potential use of media to understand the psychopathology and plight of those with psychiatric disorders is referred to. The manner in which media can be used as a tool for change to reduce the stigma surrounding mental illnesses is explored.

  12. EXTRACELLULAR VESICLES: CLASSIFICATION, FUNCTIONS AND CLINICAL RELEVANCE

    Directory of Open Access Journals (Sweden)

    A. V. Oberemko

    2014-12-01

    Full Text Available This review presents a generalized definition of vesicles as bilayer extracellular organelles of all celular forms of life: not only eu-, but also prokaryotic. The structure and composition of extracellular vesicles, history of research, nomenclature, their impact on life processes in health and disease are discussed. Moreover, vesicles may be useful as clinical instruments for biomarkers, and they are promising as biotechnological drug. However, many questions in this area are still unresolved and need to be addressed in the future. The most interesting from the point of view of practical health care represents a direction to study the effect of exosomes and microvesicles in the development and progression of a particular disease, the possibility of adjusting the pathological process by means of extracellular vesicles of a particular type, acting as an active ingredient. Relevant is the further elucidation of the role and importance of exosomes to the surrounding cells, tissues and organs at the molecular level, the prospects for the use of non-cellular vesicles as biomarkers of disease.

  13. Clinically Relevant Anticancer Polymer Paclitaxel Therapeutics

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Danbo [Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062 (China); Yu, Lei, E-mail: yu-lei@gg.nitto.co.jp [Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062 (China); Biomedical Group, Nitto Denko Technical Corporation, 501 Via Del Monte, Oceanside, CA 92058 (United States); Van, Sang [Biomedical Group, Nitto Denko Technical Corporation, 501 Via Del Monte, Oceanside, CA 92058 (United States)

    2010-12-23

    The concept of utilizing polymers in drug delivery has been extensively explored for improving the therapeutic index of small molecule drugs. In general, polymers can be used as polymer-drug conjugates or polymeric micelles. Each unique application mandates its own chemistry and controlled release of active drugs. Each polymer exhibits its own intrinsic issues providing the advantage of flexibility. However, none have as yet been approved by the U.S. Food and Drug Administration. General aspects of polymer and nano-particle therapeutics have been reviewed. Here we focus this review on specific clinically relevant anticancer polymer paclitaxel therapeutics. We emphasize their chemistry and formulation, in vitro activity on some human cancer cell lines, plasma pharmacokinetics and tumor accumulation, in vivo efficacy, and clinical outcomes. Furthermore, we include a short review of our recent developments of a novel poly(l-γ-glutamylglutamine)-paclitaxel nano-conjugate (PGG-PTX). PGG-PTX has its own unique property of forming nano-particles. It has also been shown to possess a favorable profile of pharmacokinetics and to exhibit efficacious potency. This review might shed light on designing new and better polymer paclitaxel therapeutics for potential anticancer applications in the clinic.

  14. Dogs’ Body Language Relevant to Learning Achievement

    OpenAIRE

    Hasegawa, Masashi; Ohtani, Nobuyo; Ohta, Mitsuaki

    2014-01-01

    Simple Summary For humans and dogs to live together amiably, dog training is required, and a lack of obedience training is significantly related to the prevalence of certain behavioral problems. To train efficiently, it is important that the trainer/owner ascertains the learning level of the dog. Understanding the dog’s body language helps humans understand the animal’s emotions. This study evaluated the posture of certain dog body parts during operant conditioning. Our findings suggest that ...

  15. Seeking kinetic pathways relevant to the structural evolution of metal nanoparticles

    International Nuclear Information System (INIS)

    Haldar, Paramita; Chatterjee, Abhijit

    2015-01-01

    Understanding the kinetic pathways that cause metal nanoparticles to structurally evolve over time is essential for predicting their shape and size distributions and catalytic properties. Consequently, we need detailed kinetic models that can provide such information. Most kinetic Monte Carlo models used for metal systems contain a fixed catalogue of atomic moves; the catalogue is largely constructed based on our physical understanding of the material. In some situations, it is possible that an incorrect picture of the overall dynamics is obtained when kinetic pathways that are relevant to the dynamics are missing from the catalogue. Hence, a computational framework that can systematically determine the relevant pathways is required. This work intends to fulfil this requirement. Examples involving an Ag nanoparticle are studied to illustrate how molecular dynamics (MD) calculations can be employed to find the relevant pathways in a system. Since pathways that are unlikely to be selected at short timescales can become relevant at longer times, the accuracy of the catalogue is maintained by continually seeking these pathways using MD. We discuss various aspects of our approach, namely, defining the relevance of atomic moves to the dynamics and determining when additional MD is required to ensure the desired accuracy, as well as physical insights into the Ag nanoparticle. (paper)

  16. Optimized maintenance concept of safety relevant valves related to ageing management features in nuclear power plants

    International Nuclear Information System (INIS)

    Koring, R.

    2007-01-01

    This paper presents the existing concept in E.ON Kernkraft and its sound application to ageing management issues by focussing on group 2 components such as safety relevant valves. It is demonstrated how the maintenance concept of safety relevant valves is supported by a valve diagnostic system accompanied by an applied procedure to assess the measured results with respect to the required functionality and ageing phenomena. Furthermore this concept has been developed to optimize the existing preventive maintenance of the safety relevant valves by implementing condition oriented aspects derived from the diagnostic results. The main issue of this maintenance concept is to demonstrate the high level of the secured function, reliability and performance of the safety relevant valves within an integrated ageing management. Additionally it offers improvements of all preventive maintenance issues as maintenance periods and the component related volume, spare parts management and costs. (author)

  17. Safety of 1-methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    and of the Council, taking into account the comments and objections of a scientific nature raised by Member States. 1-MNA is a substance present naturally in the human body as a normal downstream product of niacin metabolism. The Panel considers that the information provided on the composition, the specification...... frequency. The Panel notes that the human stomach does not have non-glandular epithelium and considers this finding is toxicologically not relevant for humans. At doses of 500 and 1,000 mg/kg body weight (bw), changes of the urine pH, that did not reverse in the recovery period, were reported. As adversity...

  18. Structural Model Error and Decision Relevancy

    Science.gov (United States)

    Goldsby, M.; Lusk, G.

    2017-12-01

    The extent to which climate models can underwrite specific climate policies has long been a contentious issue. Skeptics frequently deny that climate models are trustworthy in an attempt to undermine climate action, whereas policy makers often desire information that exceeds the capabilities of extant models. While not skeptics, a group of mathematicians and philosophers [Frigg et al. (2014)] recently argued that even tiny differences between the structure of a complex dynamical model and its target system can lead to dramatic predictive errors, possibly resulting in disastrous consequences when policy decisions are based upon those predictions. They call this result the Hawkmoth effect (HME), and seemingly use it to rebuke rightwing proposals to forgo mitigation in favor of adaptation. However, a vigorous debate has emerged between Frigg et al. on one side and another philosopher-mathematician pair [Winsberg and Goodwin (2016)] on the other. On one hand, Frigg et al. argue that their result shifts the burden to climate scientists to demonstrate that their models do not fall prey to the HME. On the other hand, Winsberg and Goodwin suggest that arguments like those asserted by Frigg et al. can be, if taken seriously, "dangerous": they fail to consider the variety of purposes for which models can be used, and thus too hastily undermine large swaths of climate science. They put the burden back on Frigg et al. to show their result has any effect on climate science. This paper seeks to attenuate this debate by establishing an irenic middle position; we find that there is more agreement between sides than it first seems. We distinguish a `decision standard' from a `burden of proof', which helps clarify the contributions to the debate from both sides. In making this distinction, we argue that scientists bear the burden of assessing the consequences of HME, but that the standard Frigg et al. adopt for decision relevancy is too strict.

  19. Intracranial Aneurysms of Neuro-Ophthalmologic Relevance.

    Science.gov (United States)

    Micieli, Jonathan A; Newman, Nancy J; Barrow, Daniel L; Biousse, Valérie

    2017-12-01

    Intracranial saccular aneurysms are acquired lesions that often present with neuro-ophthalmologic symptoms and signs. Recent advances in neurosurgical techniques, endovascular treatments, and neurocritical care have improved the optimal management of symptomatic unruptured aneurysms, but whether the chosen treatment has an impact on neuro-ophthalmologic outcomes remains debated. A review of the literature focused on neuro-ophthalmic manifestations and treatment of intracranial aneurysms with specific relevance to neuro-ophthalmologic outcomes was conducted using Ovid MEDLINE and EMBASE databases. Cavernous sinus aneurysms were not included in this review. Surgical clipping vs endovascular coiling for aneurysms causing third nerve palsies was compared in 13 retrospective studies representing 447 patients. Complete recovery was achieved in 78% of surgical patients compared with 44% of patients treated with endovascular coiling. However, the complication rate, hospital costs, and days spent in intensive care were reported as higher in surgically treated patients. Retrospective reviews of surgical clipping and endovascular coiling for all ocular motor nerve palsies (third, fourth, or sixth cranial nerves) revealed similar results of complete resolution in 76% and 49%, respectively. Improvement in visual deficits related to aneurysmal compression of the anterior visual pathways was also better among patients treated with clipping than with coiling. The time to treatment from onset of visual symptoms was a predictive factor of visual recovery in several studies. Few reports have specifically assessed the improvement of visual deficits after treatment with flow diverters. Decisions regarding the choice of therapy for intracranial aneurysms causing neuro-ophthalmologic signs ideally should be made at high-volume centers with access to both surgical and endovascular treatments. The status of the patient, location of the aneurysm, and experience of the treating physicians

  20. Relevant optical properties for direct restorative materials.

    Science.gov (United States)

    Pecho, Oscar E; Ghinea, Razvan; do Amaral, Erika A Navarro; Cardona, Juan C; Della Bona, Alvaro; Pérez, María M

    2016-05-01

    To evaluate relevant optical properties of esthetic direct restorative materials focusing on whitened and translucent shades. Enamel (E), body (B), dentin (D), translucent (T) and whitened (Wh) shades for E (WhE) and B (WhB) from a restorative system (Filtek Supreme XTE, 3M ESPE) were evaluated. Samples (1 mm thick) were prepared. Spectral reflectance (R%) and color coordinates (L*, a*, b*, C* and h°) were measured against black and white backgrounds, using a spectroradiometer, in a viewing booth, with CIE D65 illuminant and d/0° geometry. Scattering (S) and absorption (K) coefficients and transmittance (T%) were calculated using Kubelka-Munk's equations. Translucency (TP) and opalescence (OP) parameters and whiteness index (W*) were obtained from differences of CIELAB color coordinates. R%, S, K and T% curves from all shades were compared using VAF (Variance Accounting For) coefficient with Cauchy-Schwarz inequality. Color coordinates and optical parameters were statistically analyzed using one-way ANOVA, Tukey's test with Bonferroni correction (α=0.0007). Spectral behavior of R% and S were different for T shades. In addition, T shades showed the lowest R%, S and K values, as well as the highest T%, TP an OP values. In most cases, WhB shades showed different color and optical properties (including TP and W*) than their corresponding B shades. WhE shades showed similar mean W* values and higher mean T% and TP values than E shades. When using whitened or translucent composites, the final color is influenced not only by the intraoral background but also by the color and optical properties of multilayers used in the esthetic restoration. Copyright © 2016 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  1. Development of an ITER relevant inspection robot

    Energy Technology Data Exchange (ETDEWEB)

    Gargiulo, L.; Bayetti, P.; Cordier, J.J.; Grisolia, C.; Hatchressian, J.C. [Association Euratom-CEA, Cadarache (France). Dept. de Recherche sur la Fusion Controlee; Friconneau, J.P.; Keller, D.; Perrot, Y. [CEA-LIST Robotics and Interactive Systems Unit, Fontenay aux Roses (France)

    2007-07-01

    Robotic operations are one of the major maintenance challenges for ITER and future fusion reactors. In particular, in vessel inspection operations without loss of conditioning could be very useful. Within this framework, the aim of the project called AIA (Articulated Inspection Arm) is to demonstrate the feasibility of a multi-purpose in-vessel Remote Handling inspection system using a long reach, limited payload carrier (up to 10 kg). It is composed of 5 segments with 11 degrees of freedom and a total range of 8 m. The project is currently developed by the CEA within the European workprogramme. Its first in situ tests are planned this summer on the Tore Supra tokamak at Cadarache (France). They will validate chosen concepts for operations under ITER relevant vacuum and temperature conditions. After qualification, the arm will constitute a promising tool for generic application. Several processes are already considered for ITER maintenance and will be demonstrated on the AIA robot carrier: - The first embedded process is the viewing system. It is currently being manufactured and will allow for close visual inspection of the complex Plasma Facing Components (limiters, neutralisers, RF antennae, diagnostic windows, etc.). - In situ localisation of leakage based on helium sniffer is also studied to improve maintenance operations. - Finally the laser ablation system for PFC detritiation, also developed in CEA laboratories, is being fitted to be implanted into the robot and put into operation in Tore Supra. This paper deals with the integration of the robot in the Tore Supra tokamak and the advances in the development of the listed processes. It also introduces the current test campaign aiming to qualify the robot performance and reliability under vacuum and temperature conditions. (orig.)

  2. Development of an ITER relevant inspection robot

    Energy Technology Data Exchange (ETDEWEB)

    Gargiulo, Laurent [Association Euratom-CEA, Departement de Recherche sur la Fusion Controlee, CE Cadarache 13108 (France)], E-mail: laurent.gargiulo@cea.fr; Bayetti, Pascal; Bruno, Vincent; Cordier, Jean-Jacques [Association Euratom-CEA, Departement de Recherche sur la Fusion Controlee, CE Cadarache 13108 (France); Friconneau, Jean-Pierre [CEA-LIST Robotics and Interactive Systems Unit, CE Fontenay Aux Roses (France); Grisolia, Christian; Hatchressian, Jean-Claude; Houry, Michael [Association Euratom-CEA, Departement de Recherche sur la Fusion Controlee, CE Cadarache 13108 (France); Keller, Delphine; Perrot, Yann [CEA-LIST Robotics and Interactive Systems Unit, CE Fontenay Aux Roses (France)

    2008-12-15

    Robotic operations are one of the major maintenance challenges for ITER and future fusion reactors. In particular, in-vessel inspection operations without loss of conditioning will be mandatory. In this context, an Articulated Inspection Arm (AIA) is currently developed by the CEA within the European work programme framework, which aims at demonstrating the feasibility of a multi-purpose in-vessel Remote Handling inspection system using a long reach, limited payload carrier (up to 10 kg). It is composed of 5 segments with 8 degrees of freedom and a total range of 8 m. The first in situ tests will take place by the end of 2007 on the Tore Supra Tokamak at Cadarache (France). They will validate concepts for operations under ITER relevant vacuum and temperature conditions. After qualification, the arm will constitute a promising tool for various applications. Several processes are already considered for ITER maintenance and will be demonstrated on the AIA robot carrier: - The first embedded process is the viewing system. It is already manufactured and will allow close visual inspection of the complex Plasma Facing Components (PFC) (limiters, neutralisers, RF antenna, diagnostic windows, etc.). - In situ localisation of water leakage based on a helium sniffing system is also being studied to improve and facilitate maintenance operations. - Finally a laser ablation system for PFC detritiation, developed in CEA laboratories, is being fitted to be implemented on the robot for future operation in Tore Supra. This paper deals with the integration of the robot into Tore Supra and the progress in the development of the processes listed above. It also describes the current test campaign aiming to qualify the robot performance and reliability under vacuum and temperature conditions.

  3. Development of an ITER relevant inspection robot

    International Nuclear Information System (INIS)

    Gargiulo, L.; Bayetti, P.; Cordier, J.J.; Grisolia, C.; Hatchressian, J.C.

    2007-01-01

    Robotic operations are one of the major maintenance challenges for ITER and future fusion reactors. In particular, in vessel inspection operations without loss of conditioning could be very useful. Within this framework, the aim of the project called AIA (Articulated Inspection Arm) is to demonstrate the feasibility of a multi-purpose in-vessel Remote Handling inspection system using a long reach, limited payload carrier (up to 10 kg). It is composed of 5 segments with 11 degrees of freedom and a total range of 8 m. The project is currently developed by the CEA within the European workprogramme. Its first in situ tests are planned this summer on the Tore Supra tokamak at Cadarache (France). They will validate chosen concepts for operations under ITER relevant vacuum and temperature conditions. After qualification, the arm will constitute a promising tool for generic application. Several processes are already considered for ITER maintenance and will be demonstrated on the AIA robot carrier: - The first embedded process is the viewing system. It is currently being manufactured and will allow for close visual inspection of the complex Plasma Facing Components (limiters, neutralisers, RF antennae, diagnostic windows, etc.). - In situ localisation of leakage based on helium sniffer is also studied to improve maintenance operations. - Finally the laser ablation system for PFC detritiation, also developed in CEA laboratories, is being fitted to be implanted into the robot and put into operation in Tore Supra. This paper deals with the integration of the robot in the Tore Supra tokamak and the advances in the development of the listed processes. It also introduces the current test campaign aiming to qualify the robot performance and reliability under vacuum and temperature conditions. (orig.)

  4. Development of an ITER relevant inspection robot

    International Nuclear Information System (INIS)

    Gargiulo, Laurent; Bayetti, Pascal; Bruno, Vincent; Cordier, Jean-Jacques; Friconneau, Jean-Pierre; Grisolia, Christian; Hatchressian, Jean-Claude; Houry, Michael; Keller, Delphine; Perrot, Yann

    2008-01-01

    Robotic operations are one of the major maintenance challenges for ITER and future fusion reactors. In particular, in-vessel inspection operations without loss of conditioning will be mandatory. In this context, an Articulated Inspection Arm (AIA) is currently developed by the CEA within the European work programme framework, which aims at demonstrating the feasibility of a multi-purpose in-vessel Remote Handling inspection system using a long reach, limited payload carrier (up to 10 kg). It is composed of 5 segments with 8 degrees of freedom and a total range of 8 m. The first in situ tests will take place by the end of 2007 on the Tore Supra Tokamak at Cadarache (France). They will validate concepts for operations under ITER relevant vacuum and temperature conditions. After qualification, the arm will constitute a promising tool for various applications. Several processes are already considered for ITER maintenance and will be demonstrated on the AIA robot carrier: - The first embedded process is the viewing system. It is already manufactured and will allow close visual inspection of the complex Plasma Facing Components (PFC) (limiters, neutralisers, RF antenna, diagnostic windows, etc.). - In situ localisation of water leakage based on a helium sniffing system is also being studied to improve and facilitate maintenance operations. - Finally a laser ablation system for PFC detritiation, developed in CEA laboratories, is being fitted to be implemented on the robot for future operation in Tore Supra. This paper deals with the integration of the robot into Tore Supra and the progress in the development of the processes listed above. It also describes the current test campaign aiming to qualify the robot performance and reliability under vacuum and temperature conditions

  5. Development of clinically relevant implantable pressure sensors: perspectives and challenges.

    Science.gov (United States)

    Clausen, Ingelin; Glott, Thomas

    2014-09-22

    This review describes different aspects to consider when developing implantable pressure sensor systems. Measurement of pressure is in general highly important in clinical practice and medical research. Due to the small size, light weight and low energy consumption Micro Electro Mechanical Systems (MEMS) technology represents new possibilities for monitoring of physiological parameters inside the human body. Development of clinical relevant sensors requires close collaboration between technological experts and medical clinicians.  Site of operation, size restrictions, patient safety, and required measurement range and resolution, are only some conditions that must be taken into account. An implantable device has to operate under very hostile conditions. Long-term in vivo pressure measurements are particularly demanding because the pressure sensitive part of the sensor must be in direct or indirect physical contact with the medium for which we want to detect the pressure. New sensor packaging concepts are demanded and must be developed through combined effort between scientists in MEMS technology, material science, and biology. Before launching a new medical device on the market, clinical studies must be performed. Regulatory documents and international standards set the premises for how such studies shall be conducted and reported.

  6. Systematic reviews: guidance relevant for studies of older people.

    Science.gov (United States)

    Shenkin, Susan D; Harrison, Jennifer K; Wilkinson, Tim; Dodds, Richard M; Ioannidis, John P A

    2017-09-01

    Systematic reviews and meta-analyses are increasingly common. This article aims to provide guidance for people conducting systematic reviews relevant to the healthcare of older people. An awareness of these issues will also help people reading systematic reviews to determine whether the results will influence their clinical practice. It is essential that systematic reviews are performed by a team which includes the required technical and clinical expertise. Those performing reviews for the first time should ensure they have appropriate training and support. They must be planned and performed in a transparent and methodologically robust way: guidelines are available. The protocol should be written-and if possible published-before starting the review. Geriatricians will be interested in a table of baseline characteristics, which will help to determine if the studied samples or populations are similar to their patients. Reviews of studies of older people should consider how they will manage issues such as different age cut-offs; non-specific presentations; multiple predictors and outcomes; potential biases and confounders. Systematic reviews and meta-analyses may provide evidence to improve older people's care, or determine where new evidence is required. Newer methodologies, such as meta-analyses of individual level data, network meta-analyses and umbrella reviews, and realist synthesis, may improve the reliability and clinical utility of systematic reviews. © The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society.

  7. Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 6: how to assess relevance of the data.

    Science.gov (United States)

    Noyes, Jane; Booth, Andrew; Lewin, Simon; Carlsen, Benedicte; Glenton, Claire; Colvin, Christopher J; Garside, Ruth; Bohren, Meghan A; Rashidian, Arash; Wainwright, Megan; Tunςalp, Özge; Chandler, Jacqueline; Flottorp, Signe; Pantoja, Tomas; Tucker, Joseph D; Munthe-Kaas, Heather

    2018-01-25

    The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group. The approach has been developed to support the use of findings from qualitative evidence syntheses in decision-making, including guideline development and policy formulation. CERQual includes four components for assessing how much confidence to place in findings from reviews of qualitative research (also referred to as qualitative evidence syntheses): (1) methodological limitations, (2) coherence, (3) adequacy of data and (4) relevance. This paper is part of a series providing guidance on how to apply CERQual and focuses on CERQual's relevance component. We developed the relevance component by searching the literature for definitions, gathering feedback from relevant research communities and developing consensus through project group meetings. We tested the CERQual relevance component within several qualitative evidence syntheses before agreeing on the current definition and principles for application. When applying CERQual, we define relevance as the extent to which the body of data from the primary studies supporting a review finding is applicable to the context (perspective or population, phenomenon of interest, setting) specified in the review question. In this paper, we describe the relevance component and its rationale and offer guidance on how to assess relevance in the context of a review finding. This guidance outlines the information required to assess relevance, the steps that need to be taken to assess relevance and examples of relevance assessments. This paper provides guidance for review authors and others on undertaking an assessment of relevance in the context of the CERQual approach. Assessing the relevance component requires consideration of potentially important contextual factors at an early stage in the review process. We expect the CERQual

  8. Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information.

    Science.gov (United States)

    Barbera, Giovanni; Liang, Bo; Zhang, Lifeng; Gerfen, Charles R; Culurciello, Eugenio; Chen, Rong; Li, Yun; Lin, Da-Ting

    2016-10-05

    An influential striatal model postulates that neural activities in the striatal direct and indirect pathways promote and inhibit movement, respectively. Normal behavior requires coordinated activity in the direct pathway to facilitate intended locomotion and indirect pathway to inhibit unwanted locomotion. In this striatal model, neuronal population activity is assumed to encode locomotion relevant information. Here, we propose a novel encoding mechanism for the dorsal striatum. We identified spatially compact neural clusters in both the direct and indirect pathways. Detailed characterization revealed similar cluster organization between the direct and indirect pathways, and cluster activities from both pathways were correlated with mouse locomotion velocities. Using machine-learning algorithms, cluster activities could be used to decode locomotion relevant behavioral states and locomotion velocity. We propose that neural clusters in the dorsal striatum encode locomotion relevant information and that coordinated activities of direct and indirect pathway neural clusters are required for normal striatal controlled behavior. VIDEO ABSTRACT. Published by Elsevier Inc.

  9. Research Courses in Education Leadership Programs: Relevance in an Era of Accountability

    OpenAIRE

    Rebecca M. Bustamante; Julie P. Combs

    2011-01-01

    Master’s degree research course offerings of 72 university education leadership programs were examined to explore how relevant the courses were to the inquiry needs of practicing school leaders. Research course titles and descriptions were analyzed using content analysis. Findings revealed considerable variation in research course requirements, course titles, and course descriptions. Analysis of course descriptions indicated minimal emphasis on the research skills required for school improvem...

  10. Autonomia e relevância dos regimes The autonomy and relevance of regimes

    Directory of Open Access Journals (Sweden)

    Gustavo Seignemartin de Carvalho

    2005-12-01

    Full Text Available Teorias institucionalistas na disciplina de relações internacionais usualmente definem regimes como um conjunto de normas e regras formais ou informais que permitem a convergência de expectativas ou a padronização do comportamento de seus participantes em uma determinada área de interesses com o objetivo de resolver problemas de coordenação que tenderiam a resultados não pareto-eficientes. Como estas definições baseadas meramente na "eficiência" dos regimes não parecem suficientes para explicar sua efetividade, o presente artigo propõe uma definição diferente para regimes: a de arranjos políticos que permitem a redistribuição dos ganhos da cooperação pelos participantes em uma determinada área de interesses em um contexto de interdependência. Regimes possuiriam efetividade pela sua autonomia e relevância, ou seja, por possuírem existência objetiva autônoma da de seus participantes e por influenciarem seu comportamento e expectativas de maneiras que não podem ser reduzidas à ação individual de nenhum deles. O artigo inicia-se com uma breve discussão sobre as dificuldades terminológicas associadas ao estudo de regimes e a definição dos conceitos de autonomia e relevância. Em seguida, classifica os diversos autores participantes do debate em duas perspectivas distintas, uma que nega (não-autonomistas e outra que atribui (autonomistas aos regimes autonomia e relevância, e faz uma breve análise dos autores e tradições mais significativos para o debate, aprofundando-se nos autonomistas e nos argumentos que reforçam a hipótese aqui apresentada. Ao final, o artigo propõe uma decomposição analítica dos regimes nos quatro elementos principais que lhes propiciam autonomia e relevância: normatividade, atores, especificidade da área de interesses e interdependência complexa com o contexto.Regimes are defined by institutionalist theories in the discipline of International Relations as formal or informal sets

  11. 76 FR 39341 - Modification of Treasury Regulations Pursuant to Section 939A of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2011-07-06

    ... require the use of an assessment of credit-worthiness of a security or money market instrument, and to...: Sec. 1.1001-3 Modifications of debt instruments. * * * * * (d) * * * Example 9. [The text of the...

  12. The Environment for Professional Interaction and Relevant Practical Experience in AACSB-Accredited Accounting Programs.

    Science.gov (United States)

    Arlinghaus, Barry P.

    2002-01-01

    Responses from 276 of 1,128 faculty at Association to Advance Collegiate Schools of Business-accredited schools indicated that 231 were certified; only 96 served in professional associations; large numbers received financial support for professional activities, but only small numbers felt involvement or relevant experience (which are required for…

  13. Video coding and decoding devices and methods preserving PPG relevant information

    NARCIS (Netherlands)

    2015-01-01

    The present invention relates to a video encoding device (10, 10', 10") and method for encoding video data and to a corresponding video decoding device (60, 60') and method. To preserve PPG relevant information after encoding without requiring a large amount of additional data for the video encoder

  14. Video coding and decoding devices and methods preserving ppg relevant information

    NARCIS (Netherlands)

    2013-01-01

    The present invention relates to a video encoding device (10, 10', 10'') and method for encoding video data and to a corresponding video decoding device (60, 60') and method. To preserve PPG relevant information after encoding without requiring a large amount of additional data for the video encoder

  15. Interactive Effects of Working Memory Self-Regulatory Ability and Relevance Instructions on Text Processing

    Science.gov (United States)

    Hamilton, Nancy Jo

    2012-01-01

    Reading is a process that requires the enactment of many cognitive processes. Each of these processes uses a certain amount of working memory resources, which are severely constrained by biology. More efficiency in the function of working memory may mediate the biological limits of same. Reading relevancy instructions may be one such method to…

  16. Parental Behaviors in a Memory Relevant Setting: How Parents "Teach" Children to Remember.

    Science.gov (United States)

    Justice, Elaine M.; Coley, Denise D.

    The behavior of mothers interacting with their preschoolers in a memory-relevant situation was examined. Ten 3-year-olds and their mothers were videotaped playing a game requiring memory for the location of hidden pictures. Frequency of nine categories of parental behavior was scored: naming, verbal orienting, physical orienting, physical…

  17. Complex mixtures: Relevance of combined exposure to substances at low dose levels

    NARCIS (Netherlands)

    Leeman, W.R.; Krul, L.; Houben, G.F.

    2013-01-01

    Upon analysis of chemically complex food matrices a forest of peaks is likely to be found. Identification of these peaks and concurrent determination of the toxicological relevance upon exposure is very time consuming, expensive and often requires animal studies. Recently, a safety assessment

  18. Research Courses in Education Leadership Programs: Relevance in an Era of Accountability

    Science.gov (United States)

    Bustamante, Rebecca M.; Combs, Julie P.

    2011-01-01

    Master's degree research course offerings of 72 university education leadership programs were examined to explore how relevant the courses were to the inquiry needs of practicing school leaders. Research course titles and descriptions were analyzed using content analysis. Findings revealed considerable variation in research course requirements,…

  19. Experiments with positive, negative and topical relevance feedback

    NARCIS (Netherlands)

    Kaptein, R.; Kamps, J.; Li, R.; Hiemstra, D.

    2008-01-01

    This document contains a description of experiments for the 2008 Relevance Feedback track. We experiment with different amounts of feedback, including negative relevance feedback. Feedback is implemented using massive weighted query expansion. Parsimonious query expansion using Dirichlet smoothing

  20. 49 CFR 556.9 - Public inspection of relevant information.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Public inspection of relevant information. 556.9... NONCOMPLIANCE § 556.9 Public inspection of relevant information. Information relevant to a petition under this... Administration, 400 Seventh Street, SW., Washington, DC 20590. Copies of available information may be obtained in...

  1. 46 CFR 560.5 - Receipt of relevant information.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Receipt of relevant information. 560.5 Section 560.5... FOREIGN PORTS § 560.5 Receipt of relevant information. (a) In making its decision on matters arising under... submissions should be supported by affidavits of fact and memorandum of law. Relevant information may include...

  2. Aspect-based Relevance Learning for Image Retrieval

    NARCIS (Netherlands)

    M.J. Huiskes (Mark)

    2005-01-01

    htmlabstractWe analyze the special structure of the relevance feedback learning problem, focusing particularly on the effects of image selection by partial relevance on the clustering behavior of feedback examples. We propose a scheme, aspect-based relevance learning, which guarantees that feedback

  3. Hydrogen distribution studies relevant to CANDU containments

    International Nuclear Information System (INIS)

    Krause, M.; Whitehouse, D.R.; Chan, C.K.; Jones, S.C.A.

    1995-01-01

    Following a loss of coolant accident with coincident loss of emergency core cooling, hydrogen may be produced in a CANDU reactor from the in-core Zircaloy-steam reaction, and released into containment. To meet the requirements for predicting containment hydrogen distribution, and to support measures for mitigation, a computer code GOTHIC is used. Simulations of gas mixing were performed using simple well defined experiments in a small-scale compartment, helium being substituted for hydrogen. At the time of the conference, results indicated that GOTHIC could quantitatively predict the stratified gas distribution resulting from buoyant gas injection near the bottom of an unobstructed compartment. When gas was injected near the top, GOTHIC underpredicted maximum gas concentration at the top, and overpredicted mixing. These errors arise from the finite-volume approximation. 2 refs., 11 figs

  4. Feed tank transfer requirements

    International Nuclear Information System (INIS)

    Freeman-Pollard, J.R.

    1998-01-01

    This document presents a definition of tank turnover; DOE responsibilities; TWRS DST permitting requirements; TWRS Authorization Basis (AB) requirements; TWRS AP Tank Farm operational requirements; unreviewed safety question (USQ) requirements; records and reporting requirements, and documentation which will require revision in support of transferring a DST in AP Tank Farm to a privatization contractor for use during Phase 1B

  5. Transesophageal NOTES--a critical analysis of relevant problems.

    Science.gov (United States)

    Grund, Karl E; Lehmann, Thorsten G

    2010-10-01

    The transesophageal access route has not become a principal topic in the discussion about NOTES up to now. Analyzing the problems in this new field of surgery, however, the transesophageal route shows high relevance. Here, all possibilities, limitations, and problems of NOTES become obvious. This paper contains a critical analysis of the literature published to date (nine full papers, five abstracts). Nearly all publications represent experimental studies in living pigs. In most cases a submucosal tunnel technique is performed as access route to mediastinum, pleural cavity, and heart. Interventions and operations include simple mediastinoscopies as well as epicardial operations after exposition of the heart. For access and manipulation, conventional flexible endoscopes and instruments are used. Clips, T-bars, or a combination of both achieve the closure. Some studies rely on spontaneous closure of the incision without any suturing or approximation. In such experimental settings, the following results are presented: Access is achieved in 90% of cases, the aim of the operation is met in 92%, technical success in closure is achieved in 90%, healing of incision assessed as good in two of five studies, satisfactory in three of five studies. Mortality, ranging from 6 to 25%, and complication rates were (surprisingly) high. It has to be stressed that analyzing these papers published to date, no adequate attention is paid to basic facts and problems of general and thoracic surgery (e.g. different forms, prevention, diagnosis and therapy of pneumothorax or differentiated forms of ventilation). Relevant differences in the anatomy and physiology of the esophagus and mediastinum between humans and pigs should additionally be taken into account to choose optimal experimental parameters when transferring results to human settings. Moreover, requirements regarding sterility and hygiene in a structure like the mediastinum, which is at high risk from the point of view of infection

  6. Making academic research more relevant: A few suggestions

    Directory of Open Access Journals (Sweden)

    Abinash Panda

    2014-09-01

    Full Text Available Academic research in the domain of management scholarship, though steeped in scientific and methodological rigour, is generally found to be of little relevance to practice. The authors of this paper have revisited the rigour-relevance debate in light of recent developments and with special reference to the management research scenario in India. The central thesis of the argument is that the gulf between rigour and relevance needs to be bridged to make academic research more relevant to business organizations and practitioners. They have offered some suggestions to enhance the relevance of academic research to practice.

  7. Relevance Feedback in Content Based Image Retrieval: A Review

    Directory of Open Access Journals (Sweden)

    Manesh B. Kokare

    2011-01-01

    Full Text Available This paper provides an overview of the technical achievements in the research area of relevance feedback (RF in content-based image retrieval (CBIR. Relevance feedback is a powerful technique in CBIR systems, in order to improve the performance of CBIR effectively. It is an open research area to the researcher to reduce the semantic gap between low-level features and high level concepts. The paper covers the current state of art of the research in relevance feedback in CBIR, various relevance feedback techniques and issues in relevance feedback are discussed in detail.

  8. FINANCIAL POSITION AND ITS RELEVANCE TO STAKEHOLDERS

    Directory of Open Access Journals (Sweden)

    MIRON VASILE-CRISTIAN-IOACHIM

    2015-04-01

    Full Text Available The financial position of an economic entity is a concept that can have different meanings, depending on the stakeholder category that make its analysis. In energy sector, which is considered of high importance in the national economy, we consider that the most important category of stakeholder is the state (government, because ensuring the functionality of this sector is an crucial condition for development of others sectors from national economy. For this reason, we can look at the informational needs of other stakeholder categories trough the state’s “sine qua non” condition to ensure the optimal functionality of this sector, which manifests itself like this: the functioning of the sector involves the attraction of investors, the functioning of the sector involves the existence of human resources, the functioning of the sector cannot be ensured without the existence of commercial relations that involves suppliers and clients and for insuring the functioning of the sector it is often require various financing sources. All those aspects are giving raise to some categories of stakeholder interested over the parameters in which the energy sector entities are functioning, one of the interest domain being the financial position of the companies activating in its field. Over the present study we had in view to highlight the main present approaches regarding the concept of financial position, but also the main issues fallowed by the main stakeholder categories in their attempt to appreciate the financial position of the entities activating in energy sector which are listed to Bucharest Stock Exchange. The results of this study have showed that there is some base requirements regarding the informational needs of stakeholder regarding the financial position of the companies activating in energy sector, and those are related to the concepts of going concern, overall solvency ratio, general liquidity ratio and indebtedness degree. After this study

  9. Deciding to Adopt Requirements Traceability in Practice

    NARCIS (Netherlands)

    Blaauboer, F.A.; Blaauboer, Floris; Sikkel, Nicolaas; Aydin, M.N.

    2007-01-01

    The use of requirements traceability for information systems development (ISD) projects is not very common in practice despite its often mentioned advantages in the literature. We conducted a case study in a large IT company to identify the factors that are relevant for the decision whether or not

  10. Condensyl® and decreases sperm DNA damage which is a risk factor for male infertility: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Laboratoire Nurilia submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the s......Following an application from Laboratoire Nurilia submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  11. Xanthohumol in XERME®, a xanthohumol-enriched roasted malt extract, and protection of DNA from oxidative damage: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2018-01-01

    Following an application from TA‐XAN AG, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scient......Following an application from TA‐XAN AG, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  12. Lactose digestion from yogurt: mechanism and relevance.

    Science.gov (United States)

    Savaiano, Dennis A

    2014-05-01

    Yogurt is traditionally consumed throughout the world among populations who are seemingly unable to digest lactose. This review provides a historical overview of the studies that show lactose digestion and tolerance from yogurt by lactose-intolerant people. The lactose in yogurt is digested more efficiently than other dairy sources of lactose because the bacteria inherent in yogurt assist with its digestion. The bacterial lactase survives the acidic conditions of the stomach, apparently being physically protected within the bacterial cells and facilitated by the buffering capacity of yogurt. The increasing pH as the yogurt enters the small intestine and a slower gastrointestinal transit time allow the bacterial lactase to be active, digesting lactose from yogurt sufficiently to prevent symptoms in lactose-intolerant people. There is little difference in the lactase capability of different commercial yogurts, because they apparently contain Lactobacillus bulgaricus and Streptococcus thermophilus in sufficient quantities (10(8) bacteria/mL). However, Lactobacillus acidophilus appears to require cell membrane disruption to physically release the lactase. Compared with unflavored yogurts, flavored yogurts appear to exhibit somewhat reduced lactase activity but are still well tolerated.

  13. 78 FR 46656 - Program for Allocation of Regulatory Responsibilities Pursuant to Rule 17d-2; Notice of Filing of...

    Science.gov (United States)

    2013-08-01

    ... rules. On its face, Rule 17d-1 deals only with an SRO's obligations to enforce member compliance with.... Definitions. Unless otherwise defined in this Agreement or the context otherwise requires, the terms used in... unenforceable the remaining terms and provisions of this Agreement or affecting the validity or enforceability...

  14. 77 FR 73711 - Program for Allocation of Regulatory Responsibilities Pursuant to Rule 17d-2; Notice of Filing...

    Science.gov (United States)

    2012-12-11

    ... 240.17d-2. I. Introduction Section 19(g)(1) of the Act,\\3\\ among other things, requires every self... associated persons; (c) Discharge of its duties and obligations as a DEA; and (d) Evaluation of advertising... Customer Communications (Advertising) NYSE MKT [Amex] Rules 991 and 1106 BATS Rule 26.16 BOX Rule 4170 CBOE...

  15. 78 FR 54758 - Modification of Treasury Regulations Pursuant to Section 939A of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2013-09-06

    ... provisions under the Internal Revenue Code (Code) are affected. These regulations amend the Income Tax... Chief Counsel (Income Tax and Accounting), the Office of the Associate Chief Counsel (International) and... Excise taxes, Reporting and recordkeeping requirements. Adoption of Amendments to the Regulations...

  16. 77 FR 26660 - Guidelines for the Transfer of Excess Computers or Other Technical Equipment Pursuant to Section...

    Science.gov (United States)

    2012-05-07

    ... its mind or cannot pay the cost (go to www.Regulations.gov to see entire comment). Two revisions have... OMB control number 0505-0023. E. Executive Order 12630 This rule has been reviewed in accordance with... property under the control of a USDA agency that is no longer required for that agency's or another USDA...

  17. 29 CFR 516.2 - Employees subject to minimum wage or minimum wage and overtime provisions pursuant to section 6...

    Science.gov (United States)

    2010-07-01

    ... identification is related to the equal pay provisions of the Act which are administered by the Equal Employment Opportunity Commission. Other equal pay recordkeeping requirements are contained in 29 CFR part 1620.) (5... basis of pay by indicating the monetary amount paid on a per hour, per day, per week, per piece...

  18. 75 FR 34429 - Petition of Hard Eight Futures, LLC for Exemptive Relief, Pursuant to Section 4(c) of the...

    Science.gov (United States)

    2010-06-17

    ... conditions, to trade foreign non- narrow-based security index futures contracts where the foreign exchange... futures on broad-based security indexes; (ii) the securities comprising such an index are principally... the person within ten (10) business days that the claimant does not meet the requirements of the...

  19. Moral Learning: Conceptual foundations and normative relevance.

    Science.gov (United States)

    Railton, Peter

    2017-10-01

    What is distinctive about a bringing a learning perspective to moral psychology? Part of the answer lies in the remarkable transformations that have taken place in learning theory over the past two decades, which have revealed how powerful experience-based learning can be in the acquisition of abstract causal and evaluative representations, including generative models capable of attuning perception, cognition, affect, and action to the physical and social environment. When conjoined with developments in neuroscience, these advances in learning theory permit a rethinking of fundamental questions about the acquisition of moral understanding and its role in the guidance of behavior. For example, recent research indicates that spatial learning and navigation involve the formation of non-perspectival as well as ego-centric models of the physical environment, and that spatial representations are combined with learned information about risk and reward to guide choice and potentiate further learning. Research on infants provides evidence that they form non-perspectival expected-value representations of agents and actions as well, which help them to navigate the human environment. Such representations can be formed by highly-general mental processes such as causal and empathic simulation, and thus afford a foundation for spontaneous moral learning and action that requires no innate moral faculty and can exhibit substantial autonomy with respect to community norms. If moral learning is indeed integral with the acquisition and updating of casual and evaluative models, this affords a new way of understanding well-known but seemingly puzzling patterns in intuitive moral judgment-including the notorious "trolley problems." Copyright © 2016 The Author. Published by Elsevier B.V. All rights reserved.

  20. Dogs’ Body Language Relevant to Learning Achievement

    Science.gov (United States)

    Hasegawa, Masashi; Ohtani, Nobuyo; Ohta, Mitsuaki

    2014-01-01

    Simple Summary For humans and dogs to live together amiably, dog training is required, and a lack of obedience training is significantly related to the prevalence of certain behavioral problems. To train efficiently, it is important that the trainer/owner ascertains the learning level of the dog. Understanding the dog’s body language helps humans understand the animal’s emotions. This study evaluated the posture of certain dog body parts during operant conditioning. Our findings suggest that certain postures were related to the dog’s learning level during operant conditioning. Being aware of these postures could be helpful to understand canine emotion during learning. Abstract The facial expressions and body postures of dogs can give helpful information about their moods and emotional states. People can more effectively obedience train their dogs if we can identify the mannerisms associated with learning in dogs. The aim of this study was to clarify the dog’s body language during operant conditioning to predict achievement in the test that followed by measuring the duration of behaviors. Forty-six untrained dogs (17 males and 26 females) of various breeds were used. Each session consisted of 5 minutes of training with a treat reward followed by 3 minutes of rest and finally an operant conditioning test that consisted of 20 “hand motion” cues. The operant tests were conducted a total of nine times over three consecutive days, and the success numbers were counted. The duration of the dog’s behavior, focusing on the dog’s eyes, mouth, ears, tail and tail-wagging, was recorded during the operant conditioning sessions before the test. Particular behaviors, including wide-eyes, closed mouth, erect ears, and forward and high tail carriage, without wagging or with short and quick wagging, related to high achievement results. It is concluded that dogs' body language during operant conditioning was related to their success rate. PMID:26479883

  1. Eosinophilic Esophagitis: Relevance of Mast Cell Infiltration.

    Science.gov (United States)

    Strasser, Daniel S; Seger, Shanon; Bussmann, Christian; Pierlot, Gabin M; Groenen, Peter M A; Stalder, Anna K; Straumann, Alex

    2018-05-17

    Eosinophilic esophagitis (EoE) is a chronic-inflammatory disease characterized clinically by symptoms of esophageal dysfunction and histopathologically by a prominent eosinophilic inflammation. Despite eosinophils having histologically a pre-dominant position, their role in the immunopathogenesis of the disease is still questionable. Several other inflammatory cells are involved and may play a critical role as well. The purpose of this study was to characterize the mast cell infiltration, and to correlate it with clinical state of EoE. Using immunohistochemistry and quantitative morphometry, we extensively investigated eosinophils and mast cells in esophageal biopsies from patients with active EoE and from patients with EoE in remission, and compared the findings with healthy individuals. In EoE, epithelium and lamina propria were similarly infiltrated with eosinophils. In contrast, mast cells infiltration was limited to the epithelium, displaying a localized immune response. Interestingly, whereas epithelial mast cells and eosinophils were high in active EoE, some patients in remission e.g. normalized epithelial eosinophils, showed remaining high numbers of mast cells. Patient clustering supported 2 groups of patients in clinical remission, differentiating based on presence or absence of epithelial mast cells. Active EoE is characterized - in addition to the well-known tissue eosinophilia by a marked epithelium-restricted mast cell infiltration. Of interest, in a subgroup of patients, mast cell infiltration persisted despite clinical remission. To elucidate the clinical consequence of persistent epithelial mast cells infiltration further studies are required following patients in clinical remission longitudinally. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  2. Scientific Opinion on the safety of synthetic N-acetyl-D-neuraminic acid as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    2017-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on synthetic N-acetyl-d-neuraminic acid (NANA) as a novel food (NF) submitted pursuant to Regulation (EC) No 258/97. The information...... on the composition, the specifications, the batch-to-batch variability, stability and production process of the NF is sufficient and does not raise concerns about the safety of the NF. The NF is intended to be marketed as an ingredient in formulae and foods for infants and young children as well as an ingredient...... in a variety of foods and in food supplements for the general population. NANA is naturally present in human milk, in a bound and free form. The Margin of Exposure, which was based on the no-observed-adverse effect level (NOAEL) of 493 mg/kg body weight (bw) per day from a subchronic study and the anticipated...

  3. Lactitol and the maintenance of normal defecation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2015-01-01

    that the maintenance of normal defecation is a beneficial physiological effect. A total of 15 human intervention studies were identified as pertinent to the health claim. Twelve studies with various methodological limitations consistently showed that consumption of at least 10 g/day lactitol increases stool frequency......Following an application from DuPont Nutrition BioSciences ApS, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...... substantiation of a health claim related to lactitol and the maintenance of normal defecation. The food constituent that is the subject of the claim is lactitol. The Panel considers that the food constituent lactitol, which is the subject of the claim, is sufficiently characterised. The Panel considers...

  4. Scientific opinion on the safety of synthetic L-ergothioneine (Ergoneine®) as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    2016-01-01

    concerns. The applicant intends to use the novel food in quantities of up to 5 mg per serving in alcohol-free beverages, cereal bars, milk, fresh dairy products and chocolate. The applicant also proposes to provide the novel food as a food supplement, with a daily dose of up to 30 mg/day for adults and 20......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on synthetic l-ergothioneine, marketed as Ergoneine®, as a novel food submitted pursuant to Regulation (EC) No 258/97 of the European...... Parliament and of the Council. The novel food, synthetic l-ergothioneine, is produced by a one-pot patented manufacturing process. Chemically, l-ergothioneine is a derivative of thiolhistidine, and it is naturally present in a number of foodstuffs such as mushrooms, some varieties of black and red beans...

  5. Scientific Opinion on the safety of cranberry extract powder as a novel food ingredient pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Poulsen, Morten

    2017-01-01

    concentrate through an ethanolic extraction using an adsorptive resin column to retain the phenolic components. The Panel considers that the production process is sufficiently described and does not raise concerns about the safety of the novel food. The NF is intended to be added to beverages and yogurts...... to provide 80 mg PACs per serving. The target population is the adult general population. The mean and 95th percentile estimates for the all-user intakes from all proposed food-uses are 68 and 192 mg/day, respectively, for female adults, and 74 mg/day and 219 mg/day, respectively, for male adults. Taking......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on ‘cranberry extract powder’ as a novel food (NF) submitted pursuant to Regulation (EC) No 258/97 of the European Parliament and of the Council...

  6. The qualification of electrical components and instrumentations relevant to safety

    International Nuclear Information System (INIS)

    Zambardi, F.

    1989-03-01

    Systems and components relevant to safety of nuclear power plants must maintain their functional integrity in order to assure accident prevention and mitigation. Redundancy is utilized against random failures, nevertheless care must be taken to avoid common failures in redundant components. Main sources of degradation and common cause failures consist in the aging effects and in the changes of environmental conditions which occur during the plant life and the postulated accidents. These causes of degradation are expected to be especially significant for instrumentation and electrical equipment, which can have a primary role in safety systems. The qualification is the methodology by which component safety requirements can be met against the above mentioned causes of degradation. In this report the connection between the possible, plant conditions and the resulting degradation effects on components is preliminarily addressed. A general characterization of the qualification is then presented. Basis, methods and peculiar aspects are discussed and the qualification by testing is taken into special account. Technical and organizational aspects related to a plant qualification program are also focused. The report ends with a look to the most significant research and development activities. (author)

  7. Relevance of intracellular polarity to accuracy of eukaryotic chemotaxis

    International Nuclear Information System (INIS)

    Hiraiwa, Tetsuya; Nishikawa, Masatoshi; Shibata, Tatsuo; Nagamatsu, Akihiro; Akuzawa, Naohiro

    2014-01-01

    Eukaryotic chemotaxis is usually mediated by intracellular signals that tend to localize at the front or back of the cell. Such intracellular polarities frequently require no extracellular guidance cues, indicating that spontaneous polarization occurs in the signal network. Spontaneous polarization activity is considered relevant to the persistent motions in random cell migrations and chemotaxis. In this study, we propose a theoretical model that connects spontaneous intracellular polarity and motile ability in a chemoattractant solution. We demonstrate that the intracellular polarity can enhance the accuracy of chemotaxis. Chemotactic accuracy should also depend on chemoattractant concentration through the concentration-dependent correlation time in the polarity direction. Both the polarity correlation time and the chemotactic accuracy depend on the degree of responsiveness to the chemical gradient. We show that optimally accurate chemotaxis occurs at an intermediate responsiveness of intracellular polarity. Experimentally, we find that the persistence time of randomly migrating Dictyostelium cells depends on the chemoattractant concentration, as predicted by our theory. At the optimum responsiveness, this ameboid cell can enhance its chemotactic accuracy tenfold. (paper)

  8. Divided attention selectively impairs memory for self-relevant information.

    Science.gov (United States)

    Turk, David J; Brady-van den Bos, Mirjam; Collard, Philip; Gillespie-Smith, Karri; Conway, Martin A; Cunningham, Sheila J

    2013-05-01

    Information that is relevant to oneself tends to be remembered more than information that relates to other people, but the role of attention in eliciting this "self-reference effect" is unclear. In the present study, we assessed the importance of attention in self-referential encoding using an ownership paradigm, which required participants to encode items under conditions of imagined ownership by themselves or by another person. Previous work has established that this paradigm elicits a robust self-reference effect, with more "self-owned" items being remembered than "other-owned" items. Access to attentional resources was manipulated using divided-attention tasks at encoding. A significant self-reference effect emerged under full-attention conditions and was related to an increase in episodic recollection for self-owned items, but dividing attention eliminated this memory advantage. These findings are discussed in relation to the nature of self-referential cognition and the importance of attentional resources at encoding in the manifestation of the self-reference effect in memory.

  9. Plastic surgery in chest wall reconstruction: relevant aspects - case series

    Directory of Open Access Journals (Sweden)

    Diogo Franco

    Full Text Available Objective: to discuss the participation of Plastic Surgery in the reconstruction of the chest wall, highlighting relevant aspects of interdisciplinaryness. Methods: we analyzed charts from 20 patients who underwent extensive resection of the thoracic integument, between 2000 and 2014, recording the indication of resection, the extent and depth of the raw areas, types of reconstructions performed and complications. Results: among the 20 patients, averaging 55 years old, five were males and 15 females. They resections were: one squamous cell carcinoma, two basal cell carcinomas, five chondrosarcomas and 12 breast tumors. The extent of the bloody areas ranged from 4x9 cm to 25x40 cm. In 12 patients the resection included the muscular plane. In the remaining eight, the tumor removal achieved a total wall thickness. For reconstruction we used: one muscular flap associated with skin grafting, nine flaps and ten regional fasciocutaneous flaps. Two patients undergoing reconstruction with fasciocutaneous flaps had partially suffering of the flap, solved with employment of a myocutaneous flap. The other patients displayed no complications with the techniques used, requiring only one surgery. Conclusion: the proper assessment of local tissues and flaps available for reconstruction, in addition to the successful integration of Plastic Surgery with the specialties involved in the treatment, enable extensive resections of the chest wall and reconstructions that provide patient recovery.

  10. A principled and cosmopolitan neuroethics: considerations for international relevance.

    Science.gov (United States)

    Shook, John R; Giordano, James

    2014-01-03

    Neuroethics applies cognitive neuroscience for prescribing alterations to conceptions of self and society, and for prescriptively judging the ethical applications of neurotechnologies. Plentiful normative premises are available to ground such prescriptivity, however prescriptive neuroethics may remain fragmented by social conventions, cultural ideologies, and ethical theories. Herein we offer that an objectively principled neuroethics for international relevance requires a new meta-ethics: understanding how morality works, and how humans manage and improve morality, as objectively based on the brain and social sciences. This new meta-ethics will simultaneously equip neuroethics for evaluating and revising older cultural ideologies and ethical theories, and direct neuroethics towards scientifically valid views of encultured humans intelligently managing moralities. Bypassing absolutism, cultural essentialisms, and unrealistic ethical philosophies, neuroethics arrives at a small set of principles about proper human flourishing that are more culturally inclusive and cosmopolitan in spirit. This cosmopolitanism in turn suggests augmentations to traditional medical ethics in the form of four principled guidelines for international consideration: empowerment, non-obsolescence, self-creativity, and citizenship.

  11. A principled and cosmopolitan neuroethics: considerations for international relevance

    Science.gov (United States)

    2014-01-01

    Neuroethics applies cognitive neuroscience for prescribing alterations to conceptions of self and society, and for prescriptively judging the ethical applications of neurotechnologies. Plentiful normative premises are available to ground such prescriptivity, however prescriptive neuroethics may remain fragmented by social conventions, cultural ideologies, and ethical theories. Herein we offer that an objectively principled neuroethics for international relevance requires a new meta-ethics: understanding how morality works, and how humans manage and improve morality, as objectively based on the brain and social sciences. This new meta-ethics will simultaneously equip neuroethics for evaluating and revising older cultural ideologies and ethical theories, and direct neuroethics towards scientifically valid views of encultured humans intelligently managing moralities. Bypassing absolutism, cultural essentialisms, and unrealistic ethical philosophies, neuroethics arrives at a small set of principles about proper human flourishing that are more culturally inclusive and cosmopolitan in spirit. This cosmopolitanism in turn suggests augmentations to traditional medical ethics in the form of four principled guidelines for international consideration: empowerment, non-obsolescence, self-creativity, and citizenship. PMID:24387102

  12. Mid-IR Spectra of Refractory Minerals Relevant to Comets

    Science.gov (United States)

    Jauhari, Shekeab

    2008-09-01

    On 4 July 2005 the Spitzer Space Telescope obtained mid-IR ( 5-40 µm) spectra of the ejecta from the hypervelocity impact of the Deep Impact projectile with comet 9P/Tempel 1. Spectral modeling demonstrates that there are abundant minerals present in the ejecta including Ca/Fe/Mg-rich silicates, carbonates, phyllosilicates, water ice, amorphous carbon, and sulfides [1]. However, precise mineralogical identifications are hampered by the lack of comprehensive 5 - 40 µm spectral measurements of the emissivity for a broad compositional range of these materials. Here, we present our initial results for 2 - 50 µm transmission spectra and absorption constants for materials relevant to comets, including pyrrhotite, pyrite, and several phyllosilicate (clay) minerals. Measuring the transmission of materials over the full spectral range sensitive by Spitzer requires grinding the minerals into submicron powders and then mixing them with KBr (for the 1-25 um region) and polyethylene (16-50 um region) to form pellets. Transmission measurements of sub-micron sulfides are particularly difficult to obtain because the minerals oxidize rapidly upon grinding and subsequent handling unless special care is taken. A detailed description of our sample preparation and measurement technique will be provided to assist other researchers in their attempts to acquire similar spectra. References: [1] Lisse, C.M. et al., Science 313, 635 - 640 (2006)

  13. Get noticed and stay relevant to web users!

    Directory of Open Access Journals (Sweden)

    Tania Grove

    2004-12-01

    Full Text Available The study is based on the question why people visit some websites numerous times and other web sites only once. The problem for companies that decide to make use of the web as a marketing tool is not just how to get connected to the web, but getting noticed and staying relevant to its clients and potential clients. The main objective of this study was thus to investigate what influence people to return to a web site and what are their requirements from web sites. These answers will show how companies can ensure that people notice their websites, how they can be influenced to connect to their web sites and how these companies can retain the people connecting to their web sites as customers with diverse needs. This information will enable companies to develop and customise applicable strategies for their web sites to satisfy the needs of their target markets. The analysis of the responses showed that most of the respondents are not using the web to purchase items; that customer preferences vary and that the web is more effective than traditional media on certain variables.

  14. Relevance of travel agencies in the digital age

    Directory of Open Access Journals (Sweden)

    Mari Jansen van Rensburg

    2014-01-01

    Full Text Available In the digital age travellers have more choices and are better informed. This conceptual paper considers the evolution of business models in the travel industry and evaluates the value propositions offered by traditional retail travel agencies. Conclusions suggest that services provided by travel agents are still relevant and valuable. It was also found that the digital age offers various opportunities to agencies to harness the benefits of information communication technologies. However, awareness of its functionality and resources is required to utilize this platform to achieve economies of scale and rationalise costs. Value propositions, offered by travel agencies, also need to be altered to meet the changing customers' buying habits of tourism products. It is recommended that ICT and the Internet should become part of an integrated, customer centric marketing plan which includes online and traditional marketing tools. Travel agencies also need to engage in clear customer segmentation based on established customer needs. Despite the many technological advances, many travellers still find the idea of traveling daunting and the Internet to be intimidating and are willing to pay a premium for human interaction.

  15. Safety of synthetic trans-resveratrol as a novel food pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    food is not nutritionally disadvantageous. In accordance with the EFSA Scientific opinion on genotoxicity testing strategies, the Panel considers that the negative in vivo genotoxicity assay is sufficient to rule out the concern based on the positive in vitro chromosomal aberration tests. Reduced body......Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked for an opinion on the safety of synthetic trans-resveratrol as a novel food with a purity of ≥99% (w/w). The Panel considers that the information provided on the composition...... and specifications of the novel food is sufficient. The applicant intends to market the novel food as a food supplement in capsule or tablet form at daily doses up to 150 mg/day. The Panel considers that resveratrol does not have a nutritionally relevant role in the human diet and that the consumption of the novel...

  16. 76 FR 30717 - Notice Pursuant to Executive Order 12600 of Receipt of Freedom of Information Act (FOIA) Requests...

    Science.gov (United States)

    2011-05-26

    ... with a Federal award as required by law. For instance, CCR data elements 250-254 address Executive... of Public Law 111-212 (see 41 U.S.C. 417b, as recodified, 41 U.S.C. 2313) and in accordance with FAR... under the FOIA. 5) LEGAL BUS NAME Not exempt under the FOIA. 6) DBA NAME Not exempt under the FOIA. 7...

  17. 76 FR 28228 - Notice Pursuant to Executive Order 12600 of Receipt of Freedom of Information Act (FOIA) Requests...

    Science.gov (United States)

    2011-05-16

    ... public, as required by Section 3010 of Public Law 111-212 (see 41 U.S.C. 417b, as codified, 41 U.S.C... FOIA 4) RENEWAL DATE Not exempt under the FOIA 5) LEGAL BUS NAME Not exempt under the FOIA 6) DBA NAME... under the FOIA 14) COUNTRY CODE Not exempt under the FOIA 15) BUS START DATE Not exempt under the FOIA...

  18. Feed tank transfer requirements

    International Nuclear Information System (INIS)

    Freeman-Pollard, J.R.

    1998-01-01

    This document presents a definition of tank turnover. Also, DOE and PC responsibilities; TWRS DST permitting requirements; TWRS Authorization Basis (AB) requirements; TWRS AP Tank Farm operational requirements; unreviewed safety question (USQ) requirements are presented for two cases (i.e., tank modifications occurring before tank turnover and tank modification occurring after tank turnover). Finally, records and reporting requirements, and documentation which will require revision in support of transferring a DST in AP Tank Farm to a privatization contractor are presented

  19. Feed tank transfer requirements

    Energy Technology Data Exchange (ETDEWEB)

    Freeman-Pollard, J.R.

    1998-09-16

    This document presents a definition of tank turnover. Also, DOE and PC responsibilities; TWRS DST permitting requirements; TWRS Authorization Basis (AB) requirements; TWRS AP Tank Farm operational requirements; unreviewed safety question (USQ) requirements are presented for two cases (i.e., tank modifications occurring before tank turnover and tank modification occurring after tank turnover). Finally, records and reporting requirements, and documentation which will require revision in support of transferring a DST in AP Tank Farm to a privatization contractor are presented.

  20. The policy relevance of global environmental change research

    International Nuclear Information System (INIS)

    Yarnal, Brent

    1996-01-01

    Many scientists are striving to identify and promote the policy implications of their global change research. Much basic research on global environmental change cannot advance policy directly, but new projects can determine the relevance of their research to decision makers and build policy-relevant products into the work. Similarly, many ongoing projects can alter or add to the present science design to make the research policy relevant. Thus, this paper shows scientists working on global change how to make their research policy relevant. It demonstrates how research on physical global change relates to human dimensions studies and integrated assessments. It also presents an example of how policy relevance can be fit retroactively into a global change project (in this case, SRBEX-the Susquehanna River Basin Experiment) and how that addition can enhance the project's status and science. The paper concludes that policy relevance is desirable from social and scientific perspectives

  1. On relevant boundary perturbations of unitary minimal models

    International Nuclear Information System (INIS)

    Recknagel, A.; Roggenkamp, D.; Schomerus, V.

    2000-01-01

    We consider unitary Virasoro minimal models on the disk with Cardy boundary conditions and discuss deformations by certain relevant boundary operators, analogous to tachyon condensation in string theory. Concentrating on the least relevant boundary field, we can perform a perturbative analysis of renormalization group fixed points. We find that the systems always flow towards stable fixed points which admit no further (non-trivial) relevant perturbations. The new conformal boundary conditions are in general given by superpositions of 'pure' Cardy boundary conditions

  2. Signal Enhancement as Minimization of Relevant Information Loss

    OpenAIRE

    Geiger, Bernhard C.; Kubin, Gernot

    2012-01-01

    We introduce the notion of relevant information loss for the purpose of casting the signal enhancement problem in information-theoretic terms. We show that many algorithms from machine learning can be reformulated using relevant information loss, which allows their application to the aforementioned problem. As a particular example we analyze principle component analysis for dimensionality reduction, discuss its optimality, and show that the relevant information loss can indeed vanish if the r...

  3. Task relevance differentially shapes ventral visual stream sensitivity to visible and invisible faces

    DEFF Research Database (Denmark)

    Kouider, Sid; Barbot, Antoine; Madsen, Kristoffer Hougaard

    2016-01-01

    requires dissociating it from the top-down influences underlying conscious recognition. Here, using visual masking to abolish perceptual consciousness in humans, we report that functional magnetic resonance imaging (fMRI) responses to invisible faces in the fusiform gyrus are enhanced when they are task...... relevance crucially shapes the sensitivity of fusiform regions to face stimuli, leading from enhancement to suppression of neural activity when the top-down influences accruing from conscious recognition are prevented.......Top-down modulations of the visual cortex can be driven by task relevance. Yet, several accounts propose that the perceptual inferences underlying conscious recognition involve similar top-down modulations of sensory responses. Studying the pure impact of task relevance on sensory responses...

  4. Relevance and feasibility of Social Life Cycle Assessment from a Company Perspective

    DEFF Research Database (Denmark)

    Jørgensen, Andreas; Hauschild, Michael Zwicky; Jørgensen, Michael Søgaard

    2009-01-01

    Methodology development should reflect demands from the intended users: what are the needs of the user group and what is feasible in terms of requirements involving data and work? Mapping these questions of relevance and feasibility is thus a way to facilitate a higher degree of relevance...... of the developed methodology. For the emerging area of social life cycle assessment (SLCA), several different potential user groups may be identified. This article addresses the issues of relevance and feasibility of SLCA from a company perspective through a series of interviews among potential company users....... The empirical basis for the survey is a series of eight semi-structured interviews with larger Danish companies, all of which potentially have the capacity and will to use comprehensive social assessment methodologies. SLCA is not yet a well-defined methodology, but still it is possible to outline several...

  5. Vibigaba (germinated brown rice) and reduction of body weight in the context of an energy-restricted diet: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Loc Troi group, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  6. Sugar-free hard confectionery with at least 90% erythritol and reduction of dental plaque which reduces the risk of dental caries: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Cargill R&D Centre Europe, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  7. Vibigaba (germinated brown rice) and maintenance of normal blood cholesterol concentration: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Loc Troi group, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  8. Scientific Opinion on the substantiation of a health claim related to Equazen eye q® , a combination of EPA, DHA and GLA, and improving reading ability pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2015-01-01

    Following an application from Vifor Ltd, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  9. Short-chain fructooligosaccharides from sucrose and maintenance of normal defecation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from Beghin-Meiji and Tereos Syral, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) was asked to deliver...

  10. NWT-02, a fixed combination of lutein, zeaxanthin and docosahexaenoic acid in egg yolk and reduction of the loss of vision: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2018-01-01

    Following an application from Newtricious R&D B.V., submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...

  11. ‘Nutrimune®’ and immune defence against pathogens in the gastrointestinal and upper respiratory tracts: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from H.J. Heinz Supply Chain Europe B.V., submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  12. Stablor® and reduction of visceral fat while maintaining lean mass: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Laboratoires Nutrition et Cardiometabolisme, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  13. Vibigaba (germinated brown rice) and maintenance of long-term normal blood glucose concentration: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following an application from Loc Troi group, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  14. FHI LFC24, a bovine milk-derived casein hydrolysate, and a reduction of post-prandial blood glucose responses: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following an application from Food for Health Ireland (FHI), submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Ireland, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...

  15. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to vitamin D and risk of falling pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from DSM Nutritional Products Europe AG, submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific...

  16. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific opinion on niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    2015-01-01

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  17. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to caffeine and increased alertness pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from SmithKline Beecham Limited, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...

  18. Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to sugar beet fibre and decreasing intestinal transit time pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Nordic Sugar A/S, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Denmark, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim...

  19. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to sugar beet fibre and increasing faecal bulk pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Nordic Sugar A/S, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Denmark, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim...

  20. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014 . Scientific Opinion on the substantiation of a health claim related to zinc and normal growth pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...

  1. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific opinion on biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    2015-01-01

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...

  2. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucosamine and maintenance of joints pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Béres Pharmaceuticals Ltd., submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Hungary, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health...

  3. 17 CFR 249.501a - Form BDW, notice of withdrawal from registration as broker-dealer pursuant to § 240.15b6-1, § 240...

    Science.gov (United States)

    2010-04-01

    ... withdrawal, except for social security account numbers, disclosure of which is voluntary. The information... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form BDW, notice of withdrawal... Offers § 249.501a Form BDW, notice of withdrawal from registration as broker-dealer pursuant to § 240...

  4. Evaluating automatic attentional capture by self-relevant information.

    Science.gov (United States)

    Ocampo, Brenda; Kahan, Todd A

    2016-01-01

    Our everyday decisions and memories are inadvertently influenced by self-relevant information. For example, we are faster and more accurate at making perceptual judgments about stimuli associated with ourselves, such as our own face or name, as compared with familiar non-self-relevant stimuli. Humphreys and Sui propose a "self-attention network" to account for these effects, wherein self-relevant stimuli automatically capture our attention and subsequently enhance the perceptual processing of self-relevant information. We propose that the masked priming paradigm and continuous flash suppression represent two ways to experimentally examine these controversial claims.

  5. Explaining citizens’ perceptions of international climate-policy relevance

    International Nuclear Information System (INIS)

    Schleich, Joachim; Faure, Corinne

    2017-01-01

    This paper empirically analyses the antecedents of citizens’ perceptions of the relevance of international climate policy. Its use of representative surveys in the USA, China and Germany controls for different environmental attitudes and socio-economic factors between countries. The findings of the micro-econometric analysis suggest that the perceived relevance of international climate policy is positively affected by its perceived effectiveness, approval of the key topics discussed at international climate conferences, and environmental attitudes, but is not affected by perceived procedural justice. A higher level of perceived trust in international climate policy was positively related to perceived relevance in the USA and in China, but not in Germany. Citizens who felt that they were well informed and that their position was represented at climate summits were more likely to perceive international climate policy as relevant in China in particular. Generally, the results show only weak evidence of socio-demographic effects. - Highlights: • Perceptions of climate-policy relevance increase with perceptions of effectiveness. • In China and the USA, trust increases perceptions of climate-policy relevance. • Environmental attitudes are related to perceptions of climate-policy relevance. • In China, well-informed citizens perceive climate policy as more relevant. • Socio-demographics only weakly affect perceptions of climate-policy relevance.

  6. Clinically relevant incidental cardiovascular findings in CT examinations

    International Nuclear Information System (INIS)

    Voigt, P.; Fahnert, J.; Kahn, T.; Surov, A.; Schramm, D.; Bach, A.G.

    2017-01-01

    Incidental cardiovascular findings are a frequent phenomenon in computed tomography (CT) examinations. As the result of a dedicated PubMed search this article gives a systemic overview of the current literature on the most important incidental cardiovascular findings, their prevalence and clinical relevance. The majority of incidental cardiovascular findings are of only low clinical relevance; however, highly relevant incidental findings, such as aortic aneurysms, thromboses and thromboembolic events can also occasionally be found, especially in oncology patients. The scans from every CT examination should also be investigated for incidental findings as they can be of decisive importance for the further clinical management of patients, depending on their clinical relevance. (orig.) [de

  7. The neural correlates of implicit self-relevant processing in low self-esteem: an ERP study.

    Science.gov (United States)

    Yang, Juan; Guan, Lili; Dedovic, Katarina; Qi, Mingming; Zhang, Qinglin

    2012-08-30

    Previous neuroimaging studies have shown that implicit and explicit processing of self-relevant (schematic) material elicit activity in many of the same brain regions. Electrophysiological studies on the neural processing of explicit self-relevant cues have generally supported the view that P300 is an index of attention to self-relevant stimuli; however, there has been no study to date investigating the temporal course of implicit self-relevant processing. The current study seeks to investigate the time course involved in implicit self-processing by comparing processing of self-relevant with non-self-relevant words while subjects are making a judgment about color of the words in an implicit attention task. Sixteen low self-esteem participants were examined using event-related potentials technology (ERP). We hypothesized that this implicit attention task would involve P2 component rather than the P300 component. Indeed, P2 component has been associated with perceptual analysis and attentional allocation and may be more likely to occur in unconscious conditions such as this task. Results showed that latency of P2 component, which indexes the time required for perceptual analysis, was more prolonged in processing self-relevant words compared to processing non-self-relevant words. Our results suggested that the judgment of the color of the word interfered with automatic processing of self-relevant information and resulted in less efficient processing of self-relevant word. Together with previous ERP studies examining processing of explicit self-relevant cues, these findings suggest that the explicit and the implicit processing of self-relevant information would not elicit the same ERP components. Copyright © 2012 Elsevier B.V. All rights reserved.

  8. 18 CFR 292.203 - General requirements for qualification.

    Science.gov (United States)

    2010-04-01

    ... certification, pursuant to § 292.207(b)(1), that has been granted. (c) Hydroelectric small power production facilities located at a new dam or diversion. (1) A hydroelectric small power production facility that..., pursuant to § 292.207(b)(1), that has been granted. (c) Hydroelectric small power production facilities...

  9. Kernel-Based Relevance Analysis with Enhanced Interpretability for Detection of Brain Activity Patterns

    Directory of Open Access Journals (Sweden)

    Andres M. Alvarez-Meza

    2017-10-01

    Full Text Available We introduce Enhanced Kernel-based Relevance Analysis (EKRA that aims to support the automatic identification of brain activity patterns using electroencephalographic recordings. EKRA is a data-driven strategy that incorporates two kernel functions to take advantage of the available joint information, associating neural responses to a given stimulus condition. Regarding this, a Centered Kernel Alignment functional is adjusted to learning the linear projection that best discriminates the input feature set, optimizing the required free parameters automatically. Our approach is carried out in two scenarios: (i feature selection by computing a relevance vector from extracted neural features to facilitating the physiological interpretation of a given brain activity task, and (ii enhanced feature selection to perform an additional transformation of relevant features aiming to improve the overall identification accuracy. Accordingly, we provide an alternative feature relevance analysis strategy that allows improving the system performance while favoring the data interpretability. For the validation purpose, EKRA is tested in two well-known tasks of brain activity: motor imagery discrimination and epileptic seizure detection. The obtained results show that the EKRA approach estimates a relevant representation space extracted from the provided supervised information, emphasizing the salient input features. As a result, our proposal outperforms the state-of-the-art methods regarding brain activity discrimination accuracy with the benefit of enhanced physiological interpretation about the task at hand.

  10. SNF verification requirements imposed through 10 CFR Part 961: Interrelationship with MC ampersand A requirements for the OCRWM safeguards system

    International Nuclear Information System (INIS)

    Slater, N.; Vance, S.

    1994-01-01

    Article VI.B.2 of the Standard Contract for Disposal of Spent Nuclear Fuel and/or High-Level Radioactive Waste (10 CFR Part 961, Standard Contract) provides that spent nuclear fuel shall be subject to verification prior to acceptance by the Department of Energy. As part of the overall process for scheduling deliveries of spent nuclear fuel, the Standard Contract requires contract holders to submit detailed descriptions of the spent nuclear fuel they intend to deliver. Thus, the provision for verification in the Standard contract allows the Department the opportunity to ensure that the spent nuclear fuel intended for deliver is consistent with the description provided, and that the material is properly loaded, packaged, marked, and labeled. The Department is currently evaluating the verification requirements for spent nuclear fuel that it will establish pursuant to Article VI.B.2 of the Standard Contract. The Department recognizes that there may be significant overlap between these verification requirements and the requirements established for material control and accountability (MC ampersand A). Therefore, the Department may recommend modifications to the process established in the Standard Contract to ensure that the verification and MC ampersand A functions and activities are fully integrated

  11. An ERP Study on Self-Relevant Object Recognition

    Science.gov (United States)

    Miyakoshi, Makoto; Nomura, Michio; Ohira, Hideki

    2007-01-01

    We performed an event-related potential study to investigate the self-relevance effect in object recognition. Three stimulus categories were prepared: SELF (participant's own objects), FAMILIAR (disposable and public objects, defined as objects with less-self-relevant familiarity), and UNFAMILIAR (others' objects). The participants' task was to…

  12. Rocchio-based relevance feedback in video event retrieval

    NARCIS (Netherlands)

    Pingen, G.L.J.; de Boer, M.H.T.; Aly, Robin; Amsaleg, Laurent; Guðmundsson, Gylfi Þór; Gurrin, Cathal; Jónsson, Björn Þór; Satoh, Shin’ichi

    This paper investigates methods for user and pseudo relevance feedback in video event retrieval. Existing feedback methods achieve strong performance but adjust the ranking based on few individual examples. We propose a relevance feedback algorithm (ARF) derived from the Rocchio method, which is a

  13. The Relevance of Hyperbaric Oxygen to Combat Medicine

    Science.gov (United States)

    2001-06-01

    and Hyperbaric Conditions [les Questions medicales a caractere oprationel liees aux conditions hypobares ou hyperbares ] To order the complete...UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADPO 11081 TITLE: The Relevance of Hyperbaric Oxygen to Combat Medicine...following component part numbers comprise the compilation report: ADPO11059 thru ADP011100 UNCLASSIFIED 25-1 The Relevance of Hyperbaric Oxygen to

  14. On Reading Comprehension Teaching for English Majors under Relevance Theory

    Science.gov (United States)

    He, Ping

    2018-01-01

    Relevance Theory from the perspective of cognitive psychology argues that human communication is an ostensive-inferential process, and emphasizes the function of the optimal relevance for communication. In this sense, reading comprehension could be considered as a kind of communication in which the writer manifests his/her communication intention…

  15. Examining Hip-Hop as Culturally Relevant Pedagogy

    Science.gov (United States)

    Kim, Jung; Pulido, Isaura

    2015-01-01

    Culturally relevant pedagogy is a framework that conceptualizes the process of student learning as contingent upon educators' deep understanding of students' cultural backgrounds to co-construct knowledge and develop academic skills. Concurrently, there are a growing number of studies that explore hip-hop as a culturally relevant curriculum for…

  16. Making Learning Personally Meaningful: A New Framework for Relevance Research

    Science.gov (United States)

    Priniski, Stacy J.; Hecht, Cameron A.; Harackiewicz, Judith M.

    2018-01-01

    Personal relevance goes by many names in the motivation literature, stemming from a number of theoretical frameworks. Currently these lines of research are being conducted in parallel with little synthesis across them, perhaps because there is no unifying definition of the relevance construct within which this research can be situated. In this…

  17. Clinical relevance of findings in trials of CBT for depression

    NARCIS (Netherlands)

    Lepping, P.; Whittington, R.; Sambhi, R.S.; Lane, S.; Poole, R.; Leucht, S.; Cuijpers, P.; McCabe, R.; Waheed, W.

    2017-01-01

    Cognitive behavioural therapy (CBT) is beneficial in depression. Symptom scores can be translated into Clinical Global Impression (CGI) scale scores to indicate clinical relevance. We aimed to assess the clinical relevance of findings of randomised controlled trials (RCTs) of CBT in depression. We

  18. Advancing the Relevance Criteria for Video Search and Visual Summarization

    NARCIS (Netherlands)

    Rudinac, S.

    2013-01-01

    To facilitate finding of relevant information in ever-growing multimedia collections, a number of multimedia information retrieval solutions have been proposed over the past years. The essential element of any such solution is the relevance criterion deployed to select or rank the items from a

  19. Relevant test set using feature selection algorithm for early detection ...

    African Journals Online (AJOL)

    The objective of feature selection is to find the most relevant features for classification. Thus, the dimensionality of the information will be reduced and may improve classification's accuracy. This paper proposed a minimum set of relevant questions that can be used for early detection of dyslexia. In this research, we ...

  20. Bringing Relevance to Elearning--A Gender Perspective

    Science.gov (United States)

    Wallace, Ann; Panteli, Niki

    2018-01-01

    In this paper, we discuss the importance of relevance in the provision of eLearning for the pursuit of higher education (HE). In particular, we argue how the extant literature focuses on quality and security in the design of eLearning platforms, but pays scant attention to how relevant the platform and the programme contents are to the needs of…

  1. Constructing Contracts: Making Discrete Mathematics Relevant to Beginning Programmers

    Science.gov (United States)

    Gegg-Harrison, Timothy S.

    2005-01-01

    Although computer scientists understand the importance of discrete mathematics to the foundations of their field, computer science (CS) students do not always see the relevance. Thus, it is important to find a way to show students its relevance. The concept of program correctness is generally taught as an activity independent of the programming…

  2. Support Vector Machines: Relevance Feedback and Information Retrieval.

    Science.gov (United States)

    Drucker, Harris; Shahrary, Behzad; Gibbon, David C.

    2002-01-01

    Compares support vector machines (SVMs) to Rocchio, Ide regular and Ide dec-hi algorithms in information retrieval (IR) of text documents using relevancy feedback. If the preliminary search is so poor that one has to search through many documents to find at least one relevant document, then SVM is preferred. Includes nine tables. (Contains 24…

  3. The Relevance Of Research And Development (R&D) Programmes ...

    African Journals Online (AJOL)

    The purpose of this study was to assess the relevance of Research and Development (R&D) programmes of Nigerian universities in national development. Data was collected form 432 senior academic staff of five selected universities in Nigeria. Indicators of relevance such as quality, results, dissemination, utilization and ...

  4. Assessing Requirements Quality through Requirements Coverage

    Science.gov (United States)

    Rajan, Ajitha; Heimdahl, Mats; Woodham, Kurt

    2008-01-01

    In model-based development, the development effort is centered around a formal description of the proposed software system the model. This model is derived from some high-level requirements describing the expected behavior of the software. For validation and verification purposes, this model can then be subjected to various types of analysis, for example, completeness and consistency analysis [6], model checking [3], theorem proving [1], and test-case generation [4, 7]. This development paradigm is making rapid inroads in certain industries, e.g., automotive, avionics, space applications, and medical technology. This shift towards model-based development naturally leads to changes in the verification and validation (V&V) process. The model validation problem determining that the model accurately captures the customer's high-level requirements has received little attention and the sufficiency of the validation activities has been largely determined through ad-hoc methods. Since the model serves as the central artifact, its correctness with respect to the users needs is absolutely crucial. In our investigation, we attempt to answer the following two questions with respect to validation (1) Are the requirements sufficiently defined for the system? and (2) How well does the model implement the behaviors specified by the requirements? The second question can be addressed using formal verification. Nevertheless, the size and complexity of many industrial systems make formal verification infeasible even if we have a formal model and formalized requirements. Thus, presently, there is no objective way of answering these two questions. To this end, we propose an approach based on testing that, when given a set of formal requirements, explores the relationship between requirements-based structural test-adequacy coverage and model-based structural test-adequacy coverage. The proposed technique uses requirements coverage metrics defined in [9] on formal high-level software

  5. Relevant aspects of a quality assurance program applied to a nuclear power plant operation

    International Nuclear Information System (INIS)

    Fernandez, J.C.

    1987-01-01

    The purpose of this work was to enumerate the most relevant subjects to be taken into account for the elaboration of a Quality Assurance Program aimed to regulate a nuclear power plant operation. At first, it was necessary to point out the relevance that implies the presence of a group of personnel, experienced in quality assurance with enough knowledge on the technical and organizing aspects of the plant. Other aspect to be taken into account was the contemplation of the international requirements, through the International Atomic Energy Agency and of the national requirements that each country had set up by the corresponding regulating agencies. These organizations pointed out the minimum rules that must be followed for the adequate and efficient execution of a program. The Quality Assurance Manual and the program and work procedures constituted the Quality Assurance Program which must be checked as regards its fulfillment by auditors and quality assurance supervisions. (Author)

  6. Selection of relevant items for decommissioning costing estimation of a PWR using fuzzy logic

    International Nuclear Information System (INIS)

    Monteiro, Deiglys Borges; Busse, Alexander Lucas; Moreira, Joao M.L.; Maiorino, Jose Rubens

    2015-01-01

    The decommissioning is an important part of a nuclear power plant life cycle which may occur by technical, economical or safety reasons. Decommissioning requires carrying out a large number of tasks that should be planned in advance, involves cost evaluations, preparation of plans of activity and actual operational actions. Despite the large number of tasks, only part of them is relevant for cost estimation purpose. The technical literature and international regulatory agencies suggest a variety of methods for decommissioning cost estimation. Most of them require a very detailed knowledge of the plant and data available suitable for plants that are starting their decommissioning but not for those in the planning stage. The present work aims to apply fuzzy logic to sort out relevant items to cost estimation in order to reduce the work effort involved. The scheme uses parametric equations for specific cost items, and is applied to specific parts of the process of nuclear power plant decommissioning. (author)

  7. Selection of relevant items for decommissioning costing estimation of a PWR using fuzzy logic

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Deiglys Borges; Busse, Alexander Lucas; Moreira, Joao M.L.; Maiorino, Jose Rubens, E-mail: deiglys.monteiro@ufabc.edu.br, E-mail: alexlucasb@gmail.com, E-mail: joao.moreira@ufabc.edu.br, E-mail: joserubens.maiorino@ufabc.edu.br [Universidade Federal do ABC (CECS/UFABC), Santo Andre, SP (Brazil). Centro de Engenharia, Modelagem e Ciencias Aplicadas. Programa de Pos-Graduacao em Energia e Engenharia da Energia

    2015-07-01

    The decommissioning is an important part of a nuclear power plant life cycle which may occur by technical, economical or safety reasons. Decommissioning requires carrying out a large number of tasks that should be planned in advance, involves cost evaluations, preparation of plans of activity and actual operational actions. Despite the large number of tasks, only part of them is relevant for cost estimation purpose. The technical literature and international regulatory agencies suggest a variety of methods for decommissioning cost estimation. Most of them require a very detailed knowledge of the plant and data available suitable for plants that are starting their decommissioning but not for those in the planning stage. The present work aims to apply fuzzy logic to sort out relevant items to cost estimation in order to reduce the work effort involved. The scheme uses parametric equations for specific cost items, and is applied to specific parts of the process of nuclear power plant decommissioning. (author)

  8. Aligning seminars with Bologna requirements

    DEFF Research Database (Denmark)

    Lueg, Rainer; Lueg, Klarissa; Lauridsen, Ole

    2016-01-01

    Changes in public policy, such as the Bologna Process, require students to be equipped with multifunctional competencies to master relevant tasks in unfamiliar situations. Achieving this goal might imply a change in many curricula toward deeper learning. As a didactical means to achieve deep...... learning results, the authors suggest reciprocal peer tutoring (RPT); as a conceptual framework the authors suggest the SOLO (Structure of Observed Learning Outcomes) taxonomy and constructive alignment as suggested by Biggs and Tang. Our study presents results from the introduction of RPT in a large...... and students, suggest that RPT fosters deeper learning than does teacher-led instruction. Based on these findings, the authors also offer guidelines regarding how to implement RPT and how to overcome barriers....

  9. Relevance in the science classroom: A multidimensional analysis

    Science.gov (United States)

    Hartwell, Matthew F.

    While perceived relevance is considered a fundamental component of adaptive learning, the experience of relevance and its conceptual definition have not been well described. The mixed-methods research presented in this dissertation aimed to clarify the conceptual meaning of relevance by focusing on its phenomenological experience from the students' perspective. Following a critical literature review, I propose an identity-based model of perceived relevance that includes three components: a contextual target, an identity target, and a connection type, or lens. An empirical investigation of this model that consisted of two general phases was implemented in four 9th grade-biology classrooms. Participants in Phase 1 (N = 118) completed a series of four open-ended writing activities focused on eliciting perceived personal connections to academic content. Exploratory qualitative content analysis of a 25% random sample of the student responses was used to identify the main meaning-units of the proposed model as well as different dimensions of student relevance perceptions. These meaning-units and dimensions provided the basis for the construction of a conceptual mapping sentence capturing students' perceived relevance, which was then applied in a confirmatory analysis to all other student responses. Participants in Phase 2 (N = 139) completed a closed survey designed based on the mapping sentence to assess their perceived relevance of a biology unit. The survey also included scales assessing other domain-level motivational processes. Exploratory factor analysis and non-metric multidimensional scaling indicated a coherent conceptual structure, which included a primary interpretive relevance dimension. Comparison of the conceptual structure across various groups (randomly-split sample, gender, academic level, domain-general motivational profiles) provided support for its ubiquity and insight into variation in the experience of perceived relevance among students of different

  10. Systematic Assessment of Neutron and Gamma Backgrounds Relevant to Operational Modeling and Detection Technology Implementation

    Energy Technology Data Exchange (ETDEWEB)

    Archer, Daniel E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hornback, Donald Eric [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Johnson, Jeffrey O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nicholson, Andrew D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Patton, Bruce W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peplow, Douglas E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ayaz-Maierhafer, Birsen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-01-01

    This report summarizes the findings of a two year effort to systematically assess neutron and gamma backgrounds relevant to operational modeling and detection technology implementation. The first year effort focused on reviewing the origins of background sources and their impact on measured rates in operational scenarios of interest. The second year has focused on the assessment of detector and algorithm performance as they pertain to operational requirements against the various background sources and background levels.

  11. The public health relevance of air pollution abatement.

    Science.gov (United States)

    Künzli, N

    2002-07-01

    Assuming a causal relationship between current levels of air pollution and morbidity/mortality, it is crucial to estimate the public health relevance of the problem. The derivation of air pollution attributable cases faces inherent uncertainties and requires influential assumptions. Based on the results of the trinational impact assessment study of Austria, France, and Switzerland, where prudent estimates of the air pollution attributable cases (mortality, chronic bronchitis incidence, hospital admissions, acute bronchitis among children, restricted activity days, asthma attacks) have been made, influential uncertainties are quantified in this review. The public health impact of smoking, environmental tobacco smoke, and air pollution on the prevalence of chronic cough/phlegm are outlined. Despite all methodological caveats, impact assessment studies clearly suggest that public health largely benefits from better air quality. The studies are selective underestimates as they are strongly driven by mortality, but do not include full quantification of the impact on morbidity and their consequences on quality of life among the diseased and the caregivers. Air pollution abatement strategies are usually political in nature, targeting at polities, regulation and technology in mobile or stationary sources rather than at individuals. It is of note that key clean air strategies converge into abatement of climate change. In general, energy consumption is very closely related to both air pollution and greenhouse gases. The dominant causes of both problems are the excessive and inefficient combustion of fossil fuel. Thus, for many policy options, the benefit of air pollution abatement will go far beyond what prudent health-impact assessments may derive. From a climate change and air pollution perspective, improved energy efficiency and a strong and decisive departure from the "fossil fuel" combustion society is a science-based must. Health professionals must raise their voices

  12. Numerical and analytical solutions for problems relevant for quantum computers

    International Nuclear Information System (INIS)

    Spoerl, Andreas

    2008-01-01

    Quantum computers are one of the next technological steps in modern computer science. Some of the relevant questions that arise when it comes to the implementation of quantum operations (as building blocks in a quantum algorithm) or the simulation of quantum systems are studied. Numerical results are gathered for variety of systems, e.g. NMR systems, Josephson junctions and others. To study quantum operations (e.g. the quantum fourier transform, swap operations or multiply-controlled NOT operations) on systems containing many qubits, a parallel C++ code was developed and optimised. In addition to performing high quality operations, a closer look was given to the minimal times required to implement certain quantum operations. These times represent an interesting quantity for the experimenter as well as for the mathematician. The former tries to fight dissipative effects with fast implementations, while the latter draws conclusions in the form of analytical solutions. Dissipative effects can even be included in the optimisation. The resulting solutions are relaxation and time optimised. For systems containing 3 linearly coupled spin (1)/(2) qubits, analytical solutions are known for several problems, e.g. indirect Ising couplings and trilinear operations. A further study was made to investigate whether there exists a sufficient set of criteria to identify systems with dynamics which are invertible under local operations. Finally, a full quantum algorithm to distinguish between two knots was implemented on a spin(1)/(2) system. All operations for this experiment were calculated analytically. The experimental results coincide with the theoretical expectations. (orig.)

  13. The relevance of "non-relevant metabolites" from plant protection products (PPPs) for drinking water: the German view.

    Science.gov (United States)

    Dieter, Hermann H

    2010-03-01

    "Non-relevant metabolites" are those degradation products of plant protection products (PPPs), which are devoid of the targeted toxicities of the PPP and devoid of genotoxicity. Most often, "non-relevant metabolites" have a high affinity to the aquatic environment, are very mobile within this environment, and, usually, are also persistent. Therefore, from the point of drinking water hygiene, they must be characterized as "relevant for drinking water" like many other hydrophilic/polar environmental contaminants of different origins. "Non-relevant metabolites" may therefore penetrate to water sources used for abstraction of drinking water and may thus ultimately be present in drinking water. The presence of "non-relevant metabolites" and similar trace compounds in the water cycle may endanger drinking water quality on a long-term scale. During oxidative drinking water treatment, "non-relevant metabolites" may also serve as the starting material for toxicologically relevant transformation products similar to processes observed by drinking water disinfection with chlorine. This hypothesis was recently confirmed by the detection of the formation of N-nitroso-dimethylamine from ozone and dimethylsulfamide, a "non-relevant metabolite" of the fungicide tolylfluanide. In order to keep drinking water preferably free of "non-relevant metabolites", the German drinking water advisory board of the Federal Ministry of Health supports limiting their penetration into raw and drinking water to the functionally (agriculturally) unavoidable extent. On this background, the German Federal Environment Agency (UBA) recently has recommended two health related indication values (HRIV) to assess "non-relevant metabolites" from the view of drinking water hygiene. Considering the sometimes incomplete toxicological data base for some "non-relevant metabolites", HRIV also have the role of health related precautionary values. Depending on the completeness and quality of the toxicological

  14. Causal and Epistemic Relevance in Appeals to Authority

    Directory of Open Access Journals (Sweden)

    Sebastiano Lommi

    2015-05-01

    Full Text Available Appeals to authority have a long tradition in the history of argumentation theory. During the Middle Age they were considered legitimate and sound arguments, but after Locke’s treatment in the Essay Concerning Human Understanding their legitimacy has come under question. Traditionally, arguments from authority were considered informal arguments, but since the important work of Charles Hamblin (Hamblin, 1970 many attempts to provide a form for them have been done. The most convincing of them is the presumptive form developed by Douglas Walton and John Woods (Woods, Walton, 1974 that aims at taking into account the relevant contextual aspects in assessing the provisional validity of an appeal to authority. The soundness of an appeal depends on its meeting the adequacy conditions set to scrutinize all the relevant questions. I want to claim that this approach is compatible with the analysis of arguments in terms of relevance advanced by David Hitchcock (Hitchcock, 1992. He claims that relevance is a triadic relation between two items and a context. The first item is relevant to the second one in a given context. Different types of relevance relation exist, namely causal relevance and epistemic relevance. “Something is [causally] relevant to an outcome in a given situation if it helps to cause that outcome in the situation” (Hitchcock, 1992, p. 253, whereas it is epistemically relevant when it helps to achieve an epistemic goal in a given situation. I claim that we can adapt this conception to Walton and Krabbe’s theory of dialogue type (Walton, Krabbe, 1995, seeing the items of a relevance relation as the argument and its consequence and the context as the type of dialogue in which these arguments are advanced. According to this perspective, an argument from authority that meets the adequacy conditions has to be considered legitimate because it is an epistemically relevant relation. Therefore, my conclusion is that an analysis of appeals to

  15. How Long Should Routine EEG Be Recorded to Get Relevant Information?

    Science.gov (United States)

    Doudoux, Hannah; Skaare, Kristina; Geay, Thomas; Kahane, Philippe; Bosson, Jean L; Sabourdy, Cécile; Vercueil, Laurent

    2017-03-01

    The optimal duration of routine EEG (rEEG) has not been determined on a clinical basis. This study aims to determine the time required to obtain relevant information during rEEG with respect to the clinical request. All rEEGs performed over 3 months in unselected patients older than 14 years in an academic hospital were analyzed retrospectively. The latency required to obtain relevant information was determined for each rEEG by 2 independent readers blinded to the clinical data. EEG final diagnoses and latencies were analyzed with respect to the main clinical requests: subacute cognitive impairment, spells, transient focal neurologic manifestation or patients referred by epileptologists. From 430 rEEGs performed in the targeted period, 364 were analyzed: 92% of the pathological rEEGs were provided within the first 10 minutes of recording. Slowing background activity was diagnosed from the beginning, whereas interictal epileptiform discharges were recorded over time. Moreover, the time elapsed to demonstrate a pattern differed significantly in the clinical groups: in patients with subacute cognitive impairment, EEG abnormalities appeared within the first 10 minutes, whereas in the other groups, data could be provided over time. Patients with subacute cognitive impairment differed from those in the other groups significantly in the elapsed time required to obtain relevant information during rEEG, suggesting that 10-minute EEG recordings could be sufficient, arguing in favor of individualized rEEG. However, this conclusion does not apply to intensive care unit patients.

  16. Postmarket Requirements and Commitments

    Data.gov (United States)

    U.S. Department of Health & Human Services — Provides information to the public on postmarket requirements and commitments. The phrase postmarket requirements and commitments refers to studies and clinical...

  17. Requirements for existing buildings

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Wittchen, Kim Bjarne

    This report collects energy performance requirements for existing buildings in European member states by June 2012.......This report collects energy performance requirements for existing buildings in European member states by June 2012....

  18. Replacing reserve requirements

    OpenAIRE

    Edward J. Stevens

    1993-01-01

    An examination of the fading significance of the Federal Reserve System's reserve requirements and the recent flowering of required clearing balances, a rapidly growing feature of Reserve Bank operations.

  19. Verifying generator waste certification: NTS waste characterization QA requirements

    International Nuclear Information System (INIS)

    Williams, R.E.; Brich, R.F.

    1988-01-01

    Waste management activities managed by the US Department of Energy (DOE) at the Nevada Test Site (NTS) include the disposal of low-level wastes (LLW) and mixed waste (MW), waste which is both radioactive and hazardous. A majority of the packaged LLW is received from offsite DOE generators. Interim status for receipt of MW at the NTS Area 5 Radioactive Waste Management Site (RWMS) was received from the state of Nevada in 1987. The RWMS Mixed Waste Management Facility (MWMF) is expected to be operational in 1988 for approved DOE MW generators. The Nevada Test Site Defense Waste Acceptance Criteria and Certification Requirements (NVO-185, Revision 5) delineates waste acceptance criteria for waste disposal at the NTS. Regulation of the hazardous component of mixed waste requires the implementation of US Environmental Protection Agency (EPA) requirements pursuant to the Resource Conservation and Recovery Act (RCRA). Waste generators must implement a waste certification program to provide assurance that the disposal site waste acceptance criteria are met. The DOE/Nevada Operations Office (NV) developed guidance for generator waste certification program plans. Periodic technical audits are conducted by DOE/NV to assess performance of the waste certification programs. The audit scope is patterned from the waste certification program plan guidance as it integrates and provides a common format for the applicable criteria. The criteria focus on items and activities critical to processing, characterizing, packaging, certifying, and shipping waste

  20. Reflections on relevance: Psychotherapy and Psychosomatics in 2004.

    Science.gov (United States)

    Balon, Richard

    2005-01-01

    Relevance of an article is a highly desirable yet hardly predictable quality at the time of its publication. Article relevance is frequently measured by the impact factor of the journal where the article is published. Furthermore, impact factor, citation index and citation analysis are used as a measure of research progress and scientific wealth of a nation. The wisdom and significance of this approach to relevance is debatable and thus discussed here. In 2004, Psychotherapy and Psychosomatics published a variety of articles which, in the author's view, are clinically relevant. Several selected clinically relevant issues reviewed in this article include: the conceptualization of fibromyalgia as a stress disorder; the psychosocial impact and psychosocial interventions in cancer; the impact of alexithymia on patient care; the possible relationship between depression and nutrition (namely intake of folate and pyridoxal phosphate); the significance of hypercoagulability in panic-like anxiety; the questionable value of single isomer drugs, and the relevance and adequacy of clinimetrics versus psychometrics in clinical research. The reviewed issues seem to be relevant to clinical practice, research or both, but also to our critical thinking, and the critical review of the developments in psychiatry and psychology. Copyright 2005 S. Karger AG, Basel.