Sample records for release venus express

  1. Venus Express set for launch to the cryptic planet (United States)


    heading east. This injection is done by the first burn of the Fregat engine, due to take place at 06:52 CEST (04:52 GMT). At 08:03 CEST, about one hour and twenty minutes after lift-off and after an almost full circle around Earth, the third phase starts. While flying over Africa, Fregat will ignite for a second time to escape Earth orbit and head into the hyperbolic trajectory that will bring the spacecraft to Venus. After this burn, Fregat will gently release Venus Express, by firing a separation mechanism. With this last step, the launcher will have concluded its task. Plenty of ground activities for a successful trip Once separated from Fregat at 08:21 CEST, Venus Express will be awoken from its dormant status by a series of automatic on-board commands, such as the activation of its propulsion and thermal control systems, the deployment of solar arrays and manoeuvres to ‘orient’ itself in space. From this moment the spacecraft comes under the control of ESA’s European Space Operations Centre (ESOC) for the full duration of the mission. The flight control team co-ordinate and manage a network of ESA ground stations and antennas around the globe, to regularly communicate with the spacecraft. The New Norcia station in Australia and the Kourou station in French Guiana will in turn communicate with Venus Express in the initial phase of the mission. The first opportunity to receive a signal and confirm that the spacecraft is in good health will be the privilege of the New Norcia station about two hours after launch. In this early phase of the mission, once ESOC has taken full control of the satellite, the spacecraft will be fully activated. Operations will also include two burns of the Venus Express thrusters, to correct any possible error in the trajectory after separation from Fregat. On 28 October, the newly inaugurated Cebreros station in Spain, with its 35-metre antenna, will start to take an active part in ground network operations to relay information between

  2. Venus

    CERN Document Server

    Payment, Simone


    This straightforward but fascinating book takes a close look at Venus and shows young people just how different our neighboring planet is from our own. Known as the hottest planet, Venus is an example of the greenhouse effect to the extreme. Young readers will take a tour beneath the sulfur dioxide clouds and see the planet's surface up close with images taken by the Magellan and the Venus Express missions. This book will surely fascinate any young person interested in alien worlds.

  3. Venus Lightning: What We Have Learned from the Venus Express Fluxgate Magnetometer (United States)

    Russell, C. T.; Strangeway, R. J.; Wei, H. Y.; Zhang, T. L.


    The Venus Express magnetometer sees short (tens of milliseconds) pulses of EM waves in the Venus ionosphere as predicted by the lightning model for the PVO electric pulses. These waves are stronger than similar terrestrial signals produced by lightning.

  4. Future Drag Measurements from Venus Express (United States)

    Keating, Gerald; Mueller-Wodarg, Ingo; Forbes, Jeffrey M.; Yelle, Roger; Bruinsma, Sean; Withers, Paul; Lopez-Valverde, Miguel Angel; Theriot, Res. Assoc. Michael; Bougher, Stephen

    Beginning in July 2008 during the Venus Express Extended Mission, the European Space Agency will dramatically drop orbital periapsis from near 250km to near 180km above the Venus North Polar Region. This will allow orbital decay measurements of atmospheric densities to be made near the Venus North Pole by the VExADE (Venus Express Atmospheric Drag Experiment) whose team leader is Ingo Mueller-Wodarg. VExADE consists of two parts VExADE-ODA (Orbital Drag Analysis from radio tracking data) and VExADE-ACC (Accelerometer in situ atmospheric density measurements). Previous orbital decay measurements of the Venus thermosphere were obtained by Pioneer Venus from the 1970's into the 1990's and from Magellan in the 1990's. The major difference is that the Venus Express will provide measurements in the North Polar Region on the day and night sides, while the earlier measurements were obtained primarily near the equator. The periapsis will drift upwards in altitude similar to the earlier spacecraft and then be commanded down to its lower original values. This cycle in altitude will allow estimates of vertical structure and thus thermospheric temperatures in addition to atmospheric densities. The periapsis may eventually be lowered even further so that accelerometers can more accurately obtain density measurements of the polar atmosphere as a function of altitude, latitude, longitude, local solar time, pressure, Ls, solar activity, and solar wind on each pass. Bias in accelerometer measurements will be determined and corrected for by accelerometer measurements obtained above the discernable atmosphere on each pass. The second experiment, VExADE-ACC, is similar to the accelerometer experiments aboard Mars Global Surveyor, Mars Odyssey, and Mars Reconnaissance Orbiter that carried similar accelerometers in orbit around Mars. The risk involved in the orbital decay and accelerometer measurements is minimal. We have not lost any spacecraft orbiting Venus or Mars due to unexpected

  5. Venus Express Contributions to the Study of Planetary Lightning (United States)

    Russell, C. T.; Hart, R. A.; Zhang, T. L.


    Jupiter, and Saturn are expected to generate the electrical potential differences in their clouds sufficient to cause a breakdown in the atmosphere,creating a conducting path for the electric potential to discharge. This high-energy phenomenon creates a hot, high-pressure channel that enables chemical reactions not possible under usual local thermodynamic conditions. Thus it is of some interest to determine if lightning occurs in an atmosphere. While Venus is not usually considered one of the wet planets, lightning has been an object of interest since the Venera landers. It was observed with electromagnetic coils on Venera 11, 12, 13, 14 landers [2]. It was observed with a visible spectrometer on the Venera 9 orbits [1]. It was mapped during solar occultations by the electric antenna on the Pioneer Venus Orbiter [4]. These measurements revealed extensive lightning activity with an electromagnetic energy flux similar to that on Earth. However, the observations were limited in number in the atmosphere and to the nightside from orbit. In order to improve the understanding of Venus lightning, the Venus Express magnetometer was given a 128-Hz sampling rate that could cover much of the ELF frequencies at which lightning could be observed in the weak magnetic fields of the Venus ionosphere [5]. This investigation was immediately successful [3], but mastering the cleaning of the broadband data took several years to accomplish. Furthermore, the high polar latitudes of VEX periapsis were not the ideal locations to conduct the more global survey that was desired. Fortunately, after precessing poleward over the first few years the latitude of periapsis has returned to lower latitudes(Figures 1 and 2) and active electrical storms are now being studied. The charged constituent of the Venus atmosphere need not be water. In fact, we believe it is H2SO4 which polarizes much as water does and which freezes and melts at similar temperatures. If it is H2SO4, we would expect the

  6. Venus Express uurib Maa kurja kaksikut / ref. Triin Thalheim

    Index Scriptorium Estoniae


    9. novembril startis Baikonuri kosmodroomilt Veenusele Euroopa Kosmoseagentuuri sond Venus Express, mis peaks planeedi atmosfääri sisenema aprillis. Teadlaste sõnul peab sondi saadetav info aitama mõista naaberplaneedi kliimat ja atmosfääri ning tooma selgust, kas Maa võib kunagi Veenuse sarnaseks muutuda. Lisaks joonis: Venus Express

  7. Structure of the middle atmosphere of Venus and future observation with PFS on Venus Express. (United States)

    Zasova, L. V.; Formisano, V.; Moroz, V. I.; Ignatiev, N. I.; Khatountsev, I. A.

    Investigation of the middle atmosphere of Venus (55 -- 100 km) will allow to advance our knowledge about the most puzzling phenomena of the Venus dynamics -- its superrotation. More than 70% of all absorbed by Venus Solar energy is deposited there, results in the thermal tides generation and giving energy to support the superrotation. The importance of the tides in the middle atmosphere is manifested by the tidal character of the local time variation of the structure of the thermal field, zonal wind field (especially, behavior of the wind speed in the mid latitude jet), upper clouds, with amplitudes depending on the altitude and latitude. Investigation of the middle atmosphere is a scientific goal of the long wavelength channel of PFS on Venus Express, as well as of its short wavelength channel (the latter on the day side). The 3D temperature, aerosol, thermal wind and SO2 abundance fields, spatial distribution of abundance of H2O (possibly vertical profile), CO, HCl, HF will be obtained.

  8. Low-frequency magnetic field fluctuations in Venus' solar wind interaction region: Venus Express observations

    Directory of Open Access Journals (Sweden)

    L. Guicking


    Full Text Available We investigate wave properties of low-frequency magnetic field fluctuations in Venus' solar wind interaction region based on the measurements made on board the Venus Express spacecraft. The orbit geometry is very suitable to investigate the fluctuations in Venus' low-altitude magnetosheath and mid-magnetotail and provides an opportunity for a comparative study of low-frequency waves at Venus and Mars. The spatial distributions of the wave properties, in particular in the dayside and nightside magnetosheath as well as in the tail and mantle region, are similar to observations at Mars. As both planets do not have a global magnetic field, the interaction process of the solar wind with both planets is similar and leads to similar instabilities and wave structures. We focus on the spatial distribution of the wave intensity of the fluctuating magnetic field and detect an enhancement of the intensity in the dayside magnetosheath and a strong decrease towards the terminator. For a detailed investigation of the intensity distribution we adopt an analytical streamline model to describe the plasma flow around Venus. This allows displaying the evolution of the intensity along different streamlines. It is assumed that the waves are generated in the vicinity of the bow shock and are convected downstream with the turbulent magnetosheath flow. However, neither the different Mach numbers upstream and downstream of the bow shock, nor the variation of the cross sectional area and the flow velocity along the streamlines play probably an important role in order to explain the observed concentration of wave intensity in the dayside magnetosheath and the decay towards the nightside magnetosheath. But, the concept of freely evolving or decaying turbulence is in good qualitative agreement with the observations, as we observe a power law decay of the intensity along the streamlines. The observations support the assumption of wave convection through the magnetosheath, but

  9. Venus Express en route to probe the planet's hidden mysteries (United States)


    Venus Express will eventually manoeuvre itself into orbit around Venus in order to perform a detailed study of the structure, chemistry and dynamics of the planet's atmosphere, which is characterised by extremely high temperatures, very high atmospheric pressure, a huge greenhouse effect and as-yet inexplicable "super-rotation" which means that it speeds around the planet in just four days. The European spacecraft will also be the first orbiter to probe the planet's surface while exploiting the "visibility windows" recently discovered in the infrared waveband. The 1240 kg mass spacecraft was developed for ESA by a European industrial team led by EADS Astrium with 25 main contractors spread across 14 countries. It lifted off onboard a Soyuz-Fregat rocket, the launch service being provided by Starsem. The lift-off from the Baikonur Cosmodrome in Kazakstan this morning took place at 09:33 hours local time (04:33 Central European Time). Initial Fregat upper-stage ignition took place 9 minutes into the flight, manoeuvring the spacecraft into a low-earth parking orbit. A second firing, 1 hour 22 minutes later, boosted the spacecraft to pursue its interplanetary trajectory. Contact with Venus Express was established by ESA's European Space Operations Centre (ESOC) at Darmstadt, Germany approximately two hours after lift-off. The spacecraft has correctly oriented itself in relation to the sun and has deployed its solar arrays. All onboard systems are operating perfectly and the orbiter is communicating with the Earth via its low-gain antenna. In three days' time, it will establish communications using its high-gain antenna. Full speed ahead for Venus Venus Express is currently distancing itself from the Earth full speed, heading on its five-month 350 million kilometre journey inside our solar system. After check-outs to ensure that its onboard equipment and instrument payload are in proper working order, the spacecraft will be mothballed, with contact with the Earth being

  10. Venus winds at cloud level from VIRTIS during the Venus Express mission (United States)

    Hueso, Ricardo; Peralta, Javier; Sánchez-Lavega, Agustín.; Pérez-Hoyos, Santiago; Piccioni, Giuseppe; Drossart, Pierre


    The Venus Express (VEX) mission has been in orbit to Venus for almost four years now. The VIRTIS instrument onboard VEX observes Venus in two channels (visible and infrared) obtaining spectra and multi-wavelength images of the planet. Images in the ultraviolet range are used to study the upper cloud at 66 km while images in the infrared (1.74 μm) map the opacity of the lower cloud deck at 48 km. Here we present our latest results on the analysis of the global atmospheric dynamics at these cloud levels using a large selection over the full VIRTIS dataset. We will show the atmospheric zonal superrotation at these levels and the mean meridional motions. The zonal winds are very stable in the lower cloud at mid-latitudes to the tropics while it shows different signatures of variability in the upper cloud where solar tide effects are manifest in the data. While the upper clouds present a net meridional motion consistent with the upper branch of a Hadley cell the lower cloud present almost null global meridional motions at all latitudes but with particular features traveling both northwards and southwards in a turbulent manner depending on the cloud morphology on the observations. A particular important atmospheric feature is the South Polar vortex which might be influencing the structure of the zonal winds in the lower cloud at latitudes from the vortex location up to 55°S. Acknowledgements This work has been funded by the Spanish MICIIN AYA2009-10701 with FEDER support and Grupos Gobierno Vasco IT-464-07.

  11. Correlations between Venus nightside near infrared emissions measured by VIRTIS/Venus Express and Magellan radar data (United States)

    Mueller, N.; Helbert, J.; Hashimoto, G. L.; Tsang, C. C. C.; Erard, S.; Piccioni, G.; Drossart, P.


    Background The Venus Express Spacecraft images the nightside thermal emissions using the VIRTIS imaging spectrometer. At 1.02 micron thermal emission from the surface is penetrates the atmosphere but the signal is attenuated by scattering and absorption [1, 2]. Although the measured flux at top of the atmosphere is nonlinearly related to the original emission of the surface, it is still positively correlated with the product of surface temperature and surface emissivity [3]. The surface temperature of Venus is relatively well constrained as a monotonous function of altitude. Emissivity at 1 micron depends strongly on surface composition, in particular abundance of mafic minerals [3]. Mapping the thermal emission of the surface of Venus therefore supplements radar data as it allows to infer relative variation of surface composition. Data Processing This study examines the correlation of VIRTIS images showing a signal of the surface with all known parameters that govern radiance and applies semi empirical relations to remove the respective influences. 1. Stray sunlight is removed by subtraction of a spectrum template scaled to fit radiance at 1.4 ¹m [2] 2. Limb darkening is accounted for using a linear phase function consistent with results of radiative transfer modeling [4]. 3. Cloud opacity is determined from 1.31 ¹m and applied to 1.02 ¹m while accounting for multiple reflections between lower atmosphere and clouds [3]. Result is brightness temperature of thermal emission below the cloud deck but above the lowest 20 km of the atmosphere. 4. Influence of surface temperature and lower atmosphere absorption is determined by correlation of VIRTIS declouded brightness temperature and Magellan Topography data [5]. To further reduce the influence of cloud contrast and increase the signal of the surface, all suitable VIRTIS observations are map projected and stacked to create a map of the southern hemisphere of Venus. Observations and Interpretation As expected from

  12. Aerosol properties in the upper clouds of Venus from glory observations by the Venus Monitoring Camera (Venus Express mission) (United States)

    Markiewicz, Wojciech J.; Petrova, Elena V.; Shalygina, Oksana S.


    From the angular positions of the glory features observed on the upper cloud deck of Venus in three VMC channels (at 0.365, 0.513, and 0.965 μm), the dominating sizes of cloud particles and their refractive indices have been retrieved, and their spatial and temporal variations have been analyzed. For this, the phase profiles of brightness were compared to the single-scattering phase functions of particles of different sizes, since diffuse multiple scattering in the clouds does not move the angular positions of the glory, which is produced by the single scattering by cloud particles, but only makes them less pronounced. We presented the measured phase profiles in two ways: they were built for individual images and for individual small regions observed in series of successive images. The analysis of the data of both types has yielded consistent results. The presently retrieved radii of cloud particle average approximately 1.0-1.2 μm (though some values reach 1.4 μm) and demonstrate a variable pattern versus latitude and local solar time (LST). The decrease of particle sizes at high latitudes (down to 0.6 μm at 60°S) earlier found from the 0.965-μm and partly 0.365-μm data has been definitely confirmed in the analysis of the data of all three channels considered. To obtain the consistent estimates of particle sizes from the UV glory maximum and minimum positions, we have to vary the effective variance of the particle sizes, while it was fixed constant in our previous studies. The twofold increase of this parameter (from 0.07 to 0.14) diminishes the estimates of particle sizes by 10-15%, while the effect on the retrieved refractive index is negligible. The obtained estimates of the refractive index are more or less uniformly distributed over the covered latitude and LST ranges, and most of them are higher than those of concentrated sulfuric acid solution. This confirms our previous result obtained only at 0.965 μm, and now we may state that the cases of a

  13. The Venus flytrap attracts insects by the release of volatile organic compounds. (United States)

    Kreuzwieser, Jürgen; Scheerer, Ursel; Kruse, Jörg; Burzlaff, Tim; Honsel, Anne; Alfarraj, Saleh; Georgiev, Plamen; Schnitzler, Jörg-Peter; Ghirardo, Andrea; Kreuzer, Ines; Hedrich, Rainer; Rennenberg, Heinz


    Does Dionaea muscipula, the Venus flytrap, use a particular mechanism to attract animal prey? This question was raised by Charles Darwin 140 years ago, but it remains unanswered. This study tested the hypothesis that Dionaea releases volatile organic compounds (VOCs) to allure prey insects. For this purpose, olfactory choice bioassays were performed to elucidate if Dionaea attracts Drosophila melanogaster. The VOCs emitted by the plant were further analysed by GC-MS and proton transfer reaction-mass spectrometry (PTR-MS). The bioassays documented that Drosophila was strongly attracted by the carnivorous plant. Over 60 VOCs, including terpenes, benzenoids, and aliphatics, were emitted by Dionaea, predominantly in the light. This work further tested whether attraction of animal prey is affected by the nutritional status of the plant. For this purpose, Dionaea plants were fed with insect biomass to improve plant N status. However, although such feeding altered the VOC emission pattern by reducing terpene release, the attraction of Drosophila was not affected. From these results it is concluded that Dionaea attracts insects on the basis of food smell mimicry because the scent released has strong similarity to the bouquet of fruits and plant flowers. Such a volatile blend is emitted to attract insects searching for food to visit the deadly capture organ of the Venus flytrap.

  14. Infrared spectrometry of Venus: IR Fourier spectrometer on Venera 15 as a precursor of PFS for Venus express (United States)

    Zasova, L. V.; Moroz, V. I.; Formisano, V.; Ignatiev, N. I.; Khatuntsev, I. V.


    Thermal infrared spectrometry in the range 6-40 μm with spectral resolution of 4.5-6.5 cm -1 was realized onboard of Venera 15 for the middle atmosphere of Venus investigations. The 3-D temperature and zonal wind fields ( h, ϕ, LT) in the range 55-100 km and the 3-D aerosol field ( h, ϕ, LT) in the range 55-70 km were retrieved and analyzed. The solar related waves at isobaric levels, generated by the absorbed solar energy, were investigated. In the thermal IR spectral range the, ν1, ν2 and ν3 SO 2 and the H 2O rotational (40 μm) and vibro-rotational (6.3 μm) absorption bands are observed and used for minor compounds retrieval. An advantage of the thermal infrared spectrometry method is that both the temperature and aerosol profiles, which need for retrieval of the vertical profiles of minor compounds, are evaluated from the same spectrum. The Fourier spectrometer on Venera-15 may be considered as a precursor of the Planetary Fourier Spectrometer (PI Prof. V. Formisano), which is included in the payload of the planned Venus Express mission. It has a spectral range 0.9-45 μm, separated into two channels: a short wavelength channel (SWC) in the range 0.9-5 μm and a long wavelength channel (LWC) from 6 to 45 μm, and spectral resolution of 1-2 cm -1. In the history of planetary Fourier spectrometry the PFS is a unique instrument, which possesses a short wavelength channel. A functioning of this instrument on the polar orbit with a good spatial and local time coverage will advance our knowledge in the fundamental problems of the Venus atmosphere.

  15. Mesoscale circulation at the upper cloud level at middle latitudes from the imaging by Venus Monitoring Camera onboard Venus Express (United States)

    Patsaeva, Marina; Ignatiev, Nikolay; Markiewicz, Wojciech; Khatuntsev, Igor; Titov, Dmitrij; Patsaev, Dmitry

    The Venus Monitoring Camera onboard ESA Venus Express spacecraft acquired a great number of UV images (365 nm) allowing us to track the motion of cloud features at the upper cloud layer of Venus. A digital method developed to analyze correlation functions between two UV images provided wind vector fields on the Venus day side (9-16 hours local time) from the equator to high latitudes. Sizes and regions for the correlation were chosen empirically, as a trade-off of sensitivity against noise immunity and vary from 10(°) x7.5(°) to 20(°) x10(°) depending on the grid step, making this method suitable to investigate the mesoscale circulation. Previously, the digital method was used for investigation of the circulation at low latitudes and provided good agreement with manual tracking of the motion of cloud patterns. Here we present first results obtained by this method for middle latitudes (25(°) S-75(°) S) on the basis of 270 orbits. Comparing obtained vector fields with images for certain orbits, we found a relationship between morphological patterns of the cloud cover at middle latitudes and parameters of the circulation. Elongated cloud features, so-called streaks, are typical for middle latitudes, and their orientation varies over wide range. The behavior of the vector field of velocities depends on the angle between the streak and latitude circles. In the middle latitudes the average angle of the flow deviation from the zonal direction is equal to -5.6(°) ± 1(°) (the sign “-“ means the poleward flow, the standard error is given). For certain orbits, this angle varies from -15.6(°) ± 1(°) to 1.4(°) ± 1(°) . In some regions at latitudes above 60(°) S the meridional wind is equatorward in the morning. The relationship between the cloud cover morphology and circulation peculiarity can be attributed to the motion of the Y-feature in the upper cloud layer due to the super-rotation of the atmosphere.

  16. Densities inferred from ESA's Venus Express aerobraking campaign at 130 km altitude (United States)

    Bruinsma, Sean; Marty, Jean-Charles; Svedhem, Håkan; Williams, Adam; Mueller-Wodarg, Ingo


    In June-July 2014, ESA performed a planned aerobraking campaign with Venus Express to measure neutral densities above 130 km in Venus' atmosphere by means of the engineering accelerometers. To that purpose, the orbit perigee was lowered to approximately 130 km in order to enhance the atmospheric drag effect to the highest tolerable levels for the spacecraft; the accelerometer resolution and precision were not sufficient at higher altitudes. This campaign was requested as part of the Venus Express Atmospheric Drag Experiment (VExADE). A total of 18 orbits (i.e. days) were processed using the attitude quaternions to correctly orient the spacecraft bus and solar arrays in inertial space, which is necessary to accurately compute the exposed surface in the ram direction. The accelerometer data provide good measurements approximately from 130-140 km altitude; the length of the profiles is about 85 seconds, and they are on the early morning side (LST=4.5) at high northern latitude (70°N-82°N). The densities are a factor 2-3 larger than Hedin's VTS-3 thermosphere model, which is consistent with earlier results obtained via classical precise orbit determination at higher altitudes. Wavelike structures with amplitudes of 20% and more are detected, with wavelengths of about 100-500 km. We cannot entirely rule out that these waves are caused by the spacecraft or due to some unknown instrumental effect, but we estimate this probability to be very low.

  17. Radio Occultation Experiments with Venus Express and Mars Express using the Planetary Radio Interferometry and Doppler Experiment (PRIDE) Technique (United States)

    Bocanegra Bahamon, T.; Gurvits, L.; Molera Calves, G.; Cimo, G.; Duev, D.; Pogrebenko, S.; Dirkx, D.; Rosenblatt, P.


    The Planetary Radio Interferometry and Doppler Experiment (PRIDE) is a technique that can be used to enhance multiple radio science experiments of planetary missions. By 'eavesdropping' on the spacecraft signal using radio telescopes from different VLBI networks around the world, the PRIDE technique provides precise open-loop Doppler and VLBI observables to able to reconstruct the spacecraft's orbit. The application of this technique for atmospheric studies has been assessed by observing ESA's Venus Express (VEX) and Mars Express (MEX) during multiple Venus and Mars occultation events between 2012 and 2014. From these observing sessions density, temperature and pressure profiles of Venus and Mars neutral atmosphere and ionosphere have been retrieved. We present an error propagation analysis where the uncertainties of the atmospheric properties measured with this technique have been derived. These activities serve as demonstration of the applicability of the PRIDE technique for radio occultation studies, and provides a benchmark against the traditional Doppler tracking provided by the NASA's DSN and ESA's Estrack networks for these same purposes, in the framework of the upcoming ESA JUICE mission to the Jovian system.

  18. Exploration of Venus with the Venera-15 IR Fourier spectrometer and the Venus Express planetary Fourier spectrometer (United States)

    Zasova, L. V.; Moroz, V. I.; Formisano, V.; Ignatiev, N. I.; Khatuntsev, I. V.


    The infrared spectrometry of Venus in the range 6-45 μm allows one to sound the middle atmosphere of Venus in the altitude range 55-100 km and its cloud layer. This experiment was carried out onboard the Soviet automatic interplanetary Venera-15 station, where the Fourier spectrometer for this spectral range was installed. The measurements have shown that the main component of the cloud layer at all measured latitudes in the northern hemisphere is concentrated sulfuric acid (75-85%). The vertical profiles of temperature and aerosol were reconstructed in a self-consistent manner: the three-dimensional fields of temperature and zonal wind in the altitude range 55-100 km and aerosol at altitudes 55-70 km have been obtained, as well as vertical SO2 profiles and H2O concentration in the upper cloud layer. The solar-related waves at isobaric levels in the fields of temperature, zonal wind, and aerosol were investigated. This experiment has shown the efficiency of the method for investigation of the Venusian atmosphere. The Planetary Fourier Spectrometer has the spectral interval 0.9-45 μm and a spectral resolution of 1.8 cm-1. It will allow one to sound the middle atmosphere (55-100 km) of Venus and its cloud layer on the dayside, as well as the lower atmosphere and the planetary surface on the night side.

  19. First ever in situ observations of Venus' polar upper atmosphere density using the tracking data of the Venus Express Atmospheric Drag Experiment (VExADE) (United States)

    Rosenblatt, P.; Bruinsma, S. L.; Müller-Wodarg, I. C. F.; Häusler, B.; Svedhem, H.; Marty, J. C.


    On its highly elliptical 24 h orbit around Venus, the Venus Express (VEX) spacecraft briefly reaches a periapsis altitude of nominally 250 km. Recently, however, dedicated and intense radio tracking campaigns have taken place in August 2008, October 2009, February and April 2010, for which the periapsis altitude was lowered to the 186-176 km altitude range in order to be able to probe the upper atmosphere of Venus above the North Pole for the first time ever in situ. As the spacecraft experiences atmospheric drag, its trajectory is measurably perturbed during the periapsis pass, allowing us to infer total atmospheric mass density at the periapsis altitude. A Precise Orbit Determination (POD) of the VEX motion is performed through an iterative least-squares fitting process to the Doppler tracking data, acquired by the VEX radioscience experiment (VeRa). The drag acceleration is modelled using an initial atmospheric density model (VTS3 model, Hedin, A.E., Niemann, H.B., Kasprzak, W.T., Seiff, A. [1983]. J. Geophys. Res. 88, 73-83). A scale factor of the drag acceleration is estimated for each periapsis pass, which scales Hedin's density model in order to best fit the radio tracking data. Reliable density scale factors have been obtained for 10 passes mainly from the second (October 2009) and third (April 2010) VExADE campaigns, which indicate a lower density by a factor of about 1.8 than Hedin's model predicts. These first ever in situ polar density measurements at solar minimum have allowed us to construct a diffusive equilibrium density model for Venus' thermosphere, constrained in the lower thermosphere primarily by SPICAV-SOIR measurements and above 175 km by the VExADE drag measurements (Müller-Wodarg et al., in preparation). The preliminary results of the VExADE campaigns show that it is possible to obtain with the POD technique reliable estimates of Venus' upper atmosphere densities at an altitude of around 175 km. Future VExADE campaigns will benefit from

  20. Missions to Venus (United States)

    Titov, D. V.; Baines, K. H.; Basilevsky, A. T.; Chassefiere, E.; Chin, G.; Crisp, D.; Esposito, L. W.; Lebreton, J.-P.; Lellouch, E.; Moroz, V. I.; Nagy, A. F.; Owen, T. C.; Oyama, K.-I.; Russell, C. T.; Taylor, F. W.; Young, R. E.


    Venus has always been a fascinating objective for planetary studies. At the beginning of the space era Venus became one of the first targets for spacecraft missions. Our neighbour in the solar system and, in size, the twin sister of Earth, Venus was expected to be very similar to our planet. However, the first phase of Venus spacecraft exploration in 1962-1992 by the family of Soviet Venera and Vega spacecraft and US Mariner, Pioneer Venus, and Magellan missions discovered an entirely different, exotic world hidden behind a curtain of dense clouds. These studies gave us a basic knowledge of the conditions on the planet, but generated many more questions concerning the atmospheric composition, chemistry, structure, dynamics, surface-atmosphere interactions, atmospheric and geological evolution, and the plasma environment. Despite all of this exploration by more than 20 spacecraft, the "morning star" still remains a mysterious world. But for more than a decade Venus has been a "forgotten" planet with no new missions featuring in the plans of the world space agencies. Now we are witnessing the revival of interest in this planet: the Venus Orbiter mission is approved in Japan, Venus Express - a European orbiter mission - has successfully passed the selection procedure in ESA, and several Venus Discovery proposals are knocking at the doors of NASA. The paper presents an exciting story of Venus spacecraft exploration, summarizes open scientific problems, and builds a bridge to the future missions.

  1. Characterization of Earth as an exoplanet on the basis of VIRTIS-Venus Express data analysis. (United States)

    Oliva, Fabrizio; Piccioni, Giuseppe; D'Aversa, Emiliano; Bellucci, Giancarlo; Sindoni, Giuseppe; Grassi, Davide; Filacchione, Gianrico; Tosi, Federico; Capaccioni, Fabrizio


    The Visible and InfraRed Thermal Imaging Spectrometer (VIRTIS, Piccioni et al., 2007) on board the Venus Express spacecraft observed the planet Earth several times in the course of the mission. In particular, a subset of 48 observations has been taken from a distance at which our planet is imaged at sub-pixel size, as exoplanets are observed using current technologies. We studied this full subset to understand which spectral signatures, related to different surface and cloud types, can be identified from the integrated planet spectrum. As expected, we found that the cloud coverage has a key role in the identification of surface features and that vegetation is very difficult to be detected. To validate our results we built a simple tool capable to simulate observations of an Earth-like planet as seen from a VIRTIS-like spectrometer in the 0.3 - 5.0 μm range. The illumination and viewing geometries, along with the spectrometer instantaneous field of view and spectral grid and sampling, can be defined by the user. The spectral endmembers used to generate the planet have been selected from an observation of Earth registered from the instrument VIRTIS on board the ESA mission Rosetta, with similar characteristics, during the third flyby of the spacecraft around our planet, occurred in November 2009. Hence, we simulated planets made of: vegetation, desert, ocean, water ice clouds and liquid water clouds. Using different amounts for each spectral class we inferred the percentages that are required to identify each class when all the spectral information is integrated into a single pixel. The outcome of this analysis confirms that clouds are not a negligible issue in the research for spectral signatures, in particular those related to the habitability of a planet and its climate conditions, even when the cloud coverage is not so high. Acknowledgements: This study has been performed within the WOW project financed by INAF and thanks to the support from the Italian Space

  2. Lunar and Planetary Science XXXV: Venus (United States)


    The session "Venus" included the following reports:Preliminary Study of Laser-induced Breakdown Spectroscopy (LIBS) for a Venus Mission; Venus Surface Investigation Using VIRTIS Onboard the ESA/Venus Express Mission; Use of Magellan Images for Venus Landing Safety Assessment; Volatile Element Geochemistry in the Lower Atmosphere of Venus; Resurfacing Styles and Rates on Venus: Assessment of 18 Venusian Quadrangles; Stereo Imaging of Impact Craters in the Beta-Atla-Themis (BAT) Region, Venus; Depths of Extended Crater-related Deposits on Venus ; Potential Pyroclastic Deposit in the Nemesis Tessera (V14) Quadrangle of Venus; Relationship Between Coronae, Regional Plains and Rift Zones on Venus, Preliminary Results; Coronae of Parga Chasma, Venus; The Evolution of Four Volcano/Corona Hybrids on Venus; Calderas on Venus and Earth: Comparison and Models of Formation; Venus Festoon Deposits: Analysis of Characteristics and Modes of Emplacement; Topographic and Structural Analysis of Devana Chasma, Venus: A Propagating Rift System; Anomalous Radial Structures at Irnini Mons, Venus: A Parametric Study of Stresses on a Pressurized Hole; Analysis of Gravity and Topography Signals in Atalanta-Vinmara and Lavinia Planitiae Canali are Lava, Not River, Channels; and Formation of Venusian Channels in a Shield Paint Substrate.

  3. VIRTIS on Venus Express thermal emission spectra near 1μm (United States)

    Mueller, Nils; Tsang, Constantine; Helbert, Joern; Smrekar, Suzanne; Piccioni, Giuseppe; Drossart, Pierre


    Thermal emission from the surface of Venus is observable through narrow spectral windows close to 1μm. Surface temperature is strongly constrained by surface elevation, due to the thick and dense atmosphere. The data from Visible and InfraRed Thermal Imaging Spectrometer VIRTIS on Venus Express together with altimetry constrain surface emissivity. In VIRTIS observations at 1.02μm, strongly deformed highland plateaus (tesserae) appear to have a lower emissivity consistent with continental crust, an interpretation that implies existence of an early ocean. Comparison between the Magellan stereo digital elevation model (DEM) and altimetry shows that the altimetry height error in rough tesserae greatly exceeds the formal error. In the one tesserae outlier covered by altimetry, DEM, and VIRTIS, the height error could account for the observed emissivity variation. The radiances observed at 1.10 and 1.18μm have a different response to topography, mostly due to spectrally varying absorption in the overlying atmospheric column. Thus if the tesserae have the same emissivity as volcanic plains, its spectrum should be the same as that of plains of the correct surface elevation. In order to investigate this statistically, we create a database of all long exposure duration VIRTIS spectra in the range of 1 - 1.4μm. The spectra are corrected for the ubiquitous straylight from the dayside, based on analysis of spectra showing deep space. Because the 1.10 and 1.18μm peaks are narrow compared to the variation of instrument spectral registration, we fit each spectrum with a synthetic spectrum from an atmospheric radiative transfer model, using wavelength offset and bandwidths as parameters in addition to atmospheric variables. This dataset of ~28 million thermal emission spectra spans a wide range of southern latitudes and night local times, and thus may be useful for studies beyond the question of surface emissivity. A portion of this research was conducted at the Jet Propulsion

  4. Venus magnetosphere

    International Nuclear Information System (INIS)

    Podgornyj, I.M.


    Some peculiarities of the structure of the Venus magnetosphere are considered. A Swedish scientist H. Alfven supposes that nebular bodies with ionospheric shelles of the type of Venus atmosphere possess induced magnetospheres with dragged magnetic tails. In the Institute of Space Research of the USSR Academy of Sciences experiments on the modelling of such magnetosphere are performed. The possibility of formation of the shock wave in the body with plasma shell in the absence of the proper magnetic shell is proved. The cosmic ''Pioneer-Venus'' equipment is used to obtain such a distribution of the magnetic field depending on the distance to Venus as it was predicted by the laboratory model

  5. Venus: Our Misunderstood Sister (United States)

    Dyar, Darby; Smrekar, Suzanne E.


    Of all known bodies in the galaxy, Venus is the most Earth-like in size, composition, surface age, and incoming energy. As we search for habitable planets around other stars, learning how Venus works is critical to understanding how Earth evolved to host life, and whether rocky exoplanets in stars’ habitable zones are faraway Earths or Venuses. What caused Venus’ path to its present hostile environment, devoid of oceans, magnetic field, and plate tectonics? This talk reviews recent mission results, presents key unresolved science questions, and describes proposed missions to answer these questions.Despite its importance in understanding habitability, Venus is the least-explored rocky planet, last visited by NASA in 1994. Fundamental, unanswered questions for Venus include: 1. How did Venus evolve differently? 2. How have volatiles shaped its evolution? 3. Did Venus catastrophically resurface? 4. What geologic processes are active today? 5. Why does Venus lack plate tectonics?On Earth, plate tectonics supports long-term climate stability and habitability by cycling volatiles in and out of the mantle. New information on planetary volatiles disputes the long-held notion that Venus’ interior is dry; several lines of evidence indicate that planets start out wet, creating long-term atmospheres by outgassing. ESA’s Venus Express mission provided evidence for recent and ongoing volcanism and for Si-rich crust like Earth’s continents. New hypotheses suggest that lithospheric temperature can explain why Venus lacks tectonics, and are consistent with present-day initiation of subduction on Venus.New data are needed to answer these key questions of rocky planet evolution. Orbital IR data can be acquired through windows in Venus’ CO2-rich atmosphere, informing surface mineralogy, rock types, cloud variations, and active volcanism. High resolution gravity, radar, and topography data along with mineralogical constraints must be obtained. Mineralogy and geochemistry

  6. Analysis of energy released from core disruptive accident of sodium cooled fast reactor using CDA-ER and VENUS-II codes

    Energy Technology Data Exchange (ETDEWEB)

    Kang, S. H.; Ha, K. S. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The fast reactor has a unique feature in that rearranged core materials can produce a large increase in reactivity and recriticality. If such a rearrangement of core materials should occur rapidly, there would be a high rate of reactivity increase producing power excursions. The released energy from such an energetic recriticality might challenge the reactor vessel integrity. An analysis of the hypothetical excursions that result in the disassembly of the reactor plays an important role in a liquid metal fast reactor (LMFR) safety analysis. The analysis of such excursions generally consists of three phases (initial or pre-disassembly phase, disassembly phase, energy-work conversion phase). The first step is referred to as the 'accident initiation' or 'pre-disassembly' phase. In this phase, the accident is traced from some initiating event, such as a coolant pump failure or control rod ejection, up to a prompt critical condition where high temperatures and pressures rapidly develop in the core. Such complex processes as fuel pin failure, sodium voiding, and fuel slumping are treated in this phase. Several computer programs are available for this type of calculation, including SAS4A, MELT-II and FREADM. A number of models have been developed for this type of analysis, including the REXCO and SOCOOL-II computer programs. VENUS-II deals with the second phase (disassembly analysis). Most of the models used in the code have been based on the original work of Bethe and Tait. The disassembly motion is calculated using a set of two-dimensional hydrodynamics equations in the VENUS code. The density changes can be explicitly calculated, which in turn allows the use of a more accurate density dependent equation of state. The main functional parts of the computational model can be summarized as follows: Power and energy (point kinetics), Temperature (energy balance), Internal pressure (equation of state), Material displacement (hydrodynamics), Reactivity

  7. Analysis of energy released from core disruptive accident of sodium cooled fast reactor using CDA-ER and VENUS-II codes

    International Nuclear Information System (INIS)

    Kang, S. H.; Ha, K. S.


    The fast reactor has a unique feature in that rearranged core materials can produce a large increase in reactivity and recriticality. If such a rearrangement of core materials should occur rapidly, there would be a high rate of reactivity increase producing power excursions. The released energy from such an energetic recriticality might challenge the reactor vessel integrity. An analysis of the hypothetical excursions that result in the disassembly of the reactor plays an important role in a liquid metal fast reactor (LMFR) safety analysis. The analysis of such excursions generally consists of three phases (initial or pre-disassembly phase, disassembly phase, energy-work conversion phase). The first step is referred to as the 'accident initiation' or 'pre-disassembly' phase. In this phase, the accident is traced from some initiating event, such as a coolant pump failure or control rod ejection, up to a prompt critical condition where high temperatures and pressures rapidly develop in the core. Such complex processes as fuel pin failure, sodium voiding, and fuel slumping are treated in this phase. Several computer programs are available for this type of calculation, including SAS4A, MELT-II and FREADM. A number of models have been developed for this type of analysis, including the REXCO and SOCOOL-II computer programs. VENUS-II deals with the second phase (disassembly analysis). Most of the models used in the code have been based on the original work of Bethe and Tait. The disassembly motion is calculated using a set of two-dimensional hydrodynamics equations in the VENUS code. The density changes can be explicitly calculated, which in turn allows the use of a more accurate density dependent equation of state. The main functional parts of the computational model can be summarized as follows: Power and energy (point kinetics), Temperature (energy balance), Internal pressure (equation of state), Material displacement (hydrodynamics), Reactivity feedback (Doppler and

  8. Analysis of Venusian Atmospheric Two-Dimensional Winds and Features Using Venus Express, Akatsuki, and Ground-Based Images (United States)

    McCabe, Ryan M.; Gunnarson, Jacob; Sayanagi, Kunio M.; Blalock, John J.; Peralta, Javier; Gray, Candace L.; McGouldrick, Kevin; Imamura, Takeshi; Watanabe, Shigeto


    We investigate the horizontal dynamics of Venus’s atmosphere at cloud-top level. In particular, we focus on the atmospheric superrotation, in which the equatorial atmosphere rotates with a period of approximately 4-5 days (~60 times faster than the solid planet). The superrotation’s forcing and maintenance mechanisms remain to be explained. Temporal evolution of the zonal (latitudinal direction) wind could reveal the transport of energy and momentum in/out of the equatorial region, and eventually shed light on mechanisms that maintain the Venusian superrotation. As a first step, we characterize the zonal mean wind field of Venus between 2006 and 2013 in ultraviolet images captured by the Venus Monitoring Camera (VMC) on board the ESA Venus Express (VEX) spacecraft which observed Venus’s southern hemisphere. Our measurements show that, between 2006 and 2013, the westward wind speed at mid- to equatorial latitudes exhibit an increase of ~20 m/s; these results are consistent with previous studies by Kouyama et al. 2013 and Khatuntsev et al. 2013. The meridional component of the wind could additionally help us characterize large-scale cloud features and their evolution that may be connected to such superrotation. We also conduct ground-based observations contemporaneously with JAXA’s Akatsuki orbiter at the 3.5 m Astrophysical Research Consortium (ARC) telescope at the Apache Point Observatory (APO) in Sunspot, NM to extend our temporal coverage to present. Images we have captured at APO to date demonstrate that, even under unfavorable illumination, it is possible to see large features that could be used for large-scale feature tracking to be compared to images taken by Akatsuki. Our work has been supported by the following grants: NASA PATM NNX14AK07G, NASA MUREP NNX15AQ03A, NSF AAG 1212216, and JAXA’s ITYF Fellowship.Kouyama, T. et al (2013), J. Geophys. Res. Planets, 118, 37-46, doi:10.1029/2011JE004013.Khatuntsev et al. (2013), Icarus, 226, 140-158, doi

  9. Meeting Venus (United States)

    Sterken, Christiaan; Aspaas, Per Pippin


    On 2-3 June 2012, the University of Tromsoe hosted a conference about the cultural and scientific history of the transits of Venus. The conference took place in Tromsoe for two very specific reasons. First and foremost, the last transit of Venus of this century lent itself to be observed on the disc of the Midnight Sun in this part of Europe during the night of 5 to 6 June 2012. Second, several Venus transit expeditions in this region were central in the global enterprise of measuring the scale of the solar system in the eighteenth century. The site of the conference was the Nordnorsk Vitensenter (Science Centre of Northern Norway), which is located at the campus of the University of Tromsoe. After the conference, participants were invited to either stay in Tromsoe until the midnight of 5-6 June, or take part in a Venus transit voyage in Finnmark, during which the historical sites Vardoe, Hammerfest, and the North Cape were to be visited. The post-conference program culminated with the participants observing the transit of Venus in or near Tromsoe, Vardoe and even from a plane near Alta. These Proceedings contain a selection of the lectures delivered on 2-3 June 2012, and also a narrative description of the transit viewing from Tromsoe, Vardoe and Alta. The title of the book, Meeting Venus, refers the title of a play by the Hungarian film director, screenwriter and opera director Istvan Szabo (1938-). The autobiographical movie Meeting Venus (1991) directed by him is based on his experience directing Tannhauser at the Paris Opera in 1984. The movie brings the story of an imaginary international opera company that encounters a never ending series of difficulties and pitfalls that symbolise the challenges of any multicultural and international endeavour. As is evident from the many papers presented in this book, Meeting Venus not only contains the epic tales of the transits of the seventeenth, eighteenth and nineteenth centuries, it also covers the conference

  10. Electron optical study of the Venus Express ASPERA-4 Electron Spectrometer (ELS) top-hat electrostatic analyser

    International Nuclear Information System (INIS)

    Collinson, Glyn A; Kataria, D O; Coates, Andrew J; Tsang, Sharon M E; Arridge, Christopher S; Lewis, Gethyn R; Frahm, Rudy A; Winningham, J David; Barabash, Stas


    The performance of the Venus Express (VEX) ASPERA-4 Electron Spectrometer (ELS) is different from the nominal response shown by the ASPERA-3 ELS aboard Mars Express due to machining tolerance. Up to now, the precise mechanism for this was unknown and, therefore, the results of the experimental calibration could not be supported with a theoretical understanding of the fundamental instrument science behind the device. In this study, we show that the difference is due to a misalignment of the inner hemisphere and a widening of the entrance aperture of the instrument. The response of the VEX ELS can be approximated by a combination of a vertical offset of the inner hemisphere of ≈0.6 mm and a lateral offset of less than 0.125 mm, combined with an aperture that is ≈0.54 mm wider than nominal. The resulting K-factor, geometric factor, energy resolution and peak elevation are in good agreement with those observed experimentally. Therefore, we now have a good agreement between both laboratory calibration data and computer simulation, giving a firm foundation for future scientific data analysis

  11. Greenhouse effects on Venus (United States)

    Bell, Peter M.

    Calculations that used Pioneer-Venus measurements of atmosphere composition, temperature profiles, and radiative heating predicted Venus' surface temperature ‘very precisely,’ says the Ames Research Center. The calculations predict not only Venus' surface temperature but agree with temperatures measured at various altitudes above the surface by the four Pioneer Venus atmosphere probe craft.Using Pioneer-Venus spacecraft data, a research team has virtually proved that the searing 482° C surface temperature of Venus is due to an atmospheric greenhouse effect. Until now the Venus greenhouse effect has been largely a theory.

  12. Return to Venus of AKATSUKI, the Japanese Venus Orbiter (United States)

    Nakamura, M.; Iwagami, N.; Satoh, T.; Taguchi, M.; Watanabe, S.; Takahashi, Y.; Imamura, T.; Suzuki, M.; Ueno, M.; Yamazaki, A.; Fukuhara, T.; Yamada, M.; Ishii, N.; Ogohara, K.


    Japanese Venus Climate Orbiter 'AKATSUKI' (PLANET-C) was proposed in 2001 with strong support by international Venus science community and approved as an ISAS mission soon after the proposal. AKATSUKI and ESA's Venus Express complement each other in Venus climate study. Various coordinated observations using the two spacecraft have been planned. Also participating scientists from US have been selected. Its science target is to understand the climate of Venus. The mission life we expected was more than 2 Earth years in Venus orbit. AKATSUKI was successfully launched at 06:58:22JST on May 21, by H-IIA F17. After the separation from H-IIA, the telemetry from AKATSUKI was normally detected by DSN Goldstone station (10:00JST) and the solar cell paddles' expansion was confirmed. AKATSUKI was put into the 3-axis stabilized mode in the initial operation from Uchinoura station and the critical operation was finished at 20:00JST on the same day. The malfunction, which happened during the Venus Orbit Insertion (VOI) on7 Dec, 2010 is as follows. We set all commands on Dec. 5. Attitude control for Venus orbit insertion (VOI) was automatically done on Dec. 6. Orbital maneuver engine (OME) was fired 08:49 JST on Dec. 7. 1min. after firing the spacecraft went into the occultation region and we had no telemetry, but we expected to continuous firing for 12min. Recording on the spacecraft told us later that, unfortunately the firing continued just 152sec. and stopped. The reason of the malfunction of the OME was the blocking of check valve of the gas pressure line to push the fuel to the engine. We failed to make the spacecraft the Venus orbiter, and it is rotating the sun with the orbital period of 203 days. As the Venus orbit the sun with the period of 225 days, AKATSUKI has a chance to meet Venus again in 5 or 6 years depending on the orbit correction plan. Let us summarize the present situation of AKATSUKI. Most of the fuel still remains. But the condition of the propulsion

  13. Venus - Ishtar gravity anomaly (United States)

    Sjogren, W. L.; Bills, B. G.; Mottinger, N. A.


    The gravity anomaly associated with Ishtar Terra on Venus is characterized, comparing line-of-sight acceleration profiles derived by differentiating Pioneer Venus Orbiter Doppler residual profiles with an Airy-compensated topographic model. The results are presented in graphs and maps, confirming the preliminary findings of Phillips et al. (1979). The isostatic compensation depth is found to be 150 + or - 30 km.

  14. Venus Landsailing Rover (United States)

    National Aeronautics and Space Administration — NASA Glenn has developed electronics and low-power photovoltaics that will continue to function even at the Venus temperature of 450°C. So the fundamental elements...

  15. Transits of Venus and Mercury as muses (United States)

    Tobin, William


    Transits of Venus and Mercury have inspired artistic creation of all kinds. After having been the first to witness a Venusian transit, in 1639, Jeremiah Horrocks expressed his feelings in poetry. Production has subsequently widened to include songs, short stories, novels, novellas, sermons, theatre, film, engravings, paintings, photography, medals, sculpture, stained glass, cartoons, stamps, music, opera, flower arrangements, and food and drink. Transit creations are reviewed, with emphasis on the English- and French-speaking worlds. It is found that transits of Mercury inspire much less creation than those of Venus, despite being much more frequent, and arguably of no less astronomical significance. It is suggested that this is primarily due to the mythological associations of Venus with sex and love, which are more powerful and gripping than Mercury's mythological role as a messenger and protector of traders and thieves. The lesson for those presenting the night sky to the public is that sex sells.

  16. Venus Elongation Measurements for the Transit of Venus, using the ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 11. Venus Elongation Measurements for the Transit of Venus, using the Historical Jantar Mantar Observatory. N Rathnasree. Classroom Volume 9 Issue 11 November 2004 pp 46-55 ...

  17. Venus Surface Composition Constrained by Observation and Experiment (United States)

    Gilmore, Martha; Treiman, Allan; Helbert, Jörn; Smrekar, Suzanne


    New observations from the Venus Express spacecraft as well as theoretical and experimental investigation of Venus analogue materials have advanced our understanding of the petrology of Venus melts and the mineralogy of rocks on the surface. The VIRTIS instrument aboard Venus Express provided a map of the southern hemisphere of Venus at ˜1 μm allowing, for the first time, the definition of surface units in terms of their 1 μm emissivity and derived mineralogy. Tessera terrain has lower emissivity than the presumably basaltic plains, consistent with a more silica-rich or felsic mineralogy. Thermodynamic modeling and experimental production of melts with Venera and Vega starting compositions predict derivative melts that range from mafic to felsic. Large volumes of felsic melts require water and may link the formation of tesserae to the presence of a Venus ocean. Low emissivity rocks may also be produced by atmosphere-surface weathering reactions unlike those seen presently. High 1 μm emissivity values correlate to stratigraphically recent flows and have been used with theoretical and experimental predictions of basalt weathering to identify regions of recent volcanism. The timescale of this volcanism is currently constrained by the weathering of magnetite (higher emissivity) in fresh basalts to hematite (lower emissivity) in Venus' oxidizing environment. Recent volcanism is corroborated by transient thermal anomalies identified by the VMC instrument aboard Venus Express. The interpretation of all emissivity data depends critically on understanding the composition of surface materials, kinetics of rock weathering and their measurement under Venus conditions. Extended theoretical studies, continued analysis of earlier spacecraft results, new atmospheric data, and measurements of mineral stability under Venus conditions have improved our understanding atmosphere-surface interactions. The calcite-wollastonite CO2 buffer has been discounted due, among other things, to

  18. Clouds of Venus

    Energy Technology Data Exchange (ETDEWEB)

    Knollenberg, R G [Particle Measuring Systems, Inc., 1855 South 57th Court, Boulder, Colorado 80301, U.S.A.; Hansen, J [National Aeronautics and Space Administration, New York (USA). Goddard Inst. for Space Studies; Ragent, B [National Aeronautics and Space Administration, Moffett Field, Calif. (USA). Ames Research Center; Martonchik, J [Jet Propulsion Lab., Pasadena, Calif. (USA); Tomasko, M [Arizona Univ., Tucson (USA)


    The current state of knowledge of the Venusian clouds is reviewed. The visible clouds of Venus are shown to be quite similar to low level terrestrial hazes of strong anthropogenic influence. Possible nucleation and particle growth mechanisms are presented. The Pioneer Venus experiments that emphasize cloud measurements are described and their expected findings are discussed in detail. The results of these experiments should define the cloud particle composition, microphysics, thermal and radiative heat budget, rough dynamical features and horizontal and vertical variations in these and other parameters. This information should be sufficient to initialize cloud models which can be used to explain the cloud formation, decay, and particle life cycle.

  19. From CERN to VENUS Express

    CERN Document Server


    Participants in the 'Schweizer Jugendforscht' projects at CERN under the supervision of Günther Dissertori, professor at the Swiss Federal Institute of Technology (ETH Zürich) and other members of ETH Zürich, Werner Lustermann and Michael Dittmar. In Switzerland, as in many other countries, this year has seen a long list of activities, celebrating the centenary of Einstein's 'Annus mirabilis'. Having formerly employed Einstein, the Swiss Federal Institute of Intellectual Property in Bern made its contribution by sponsoring a special 'study week' for young high-school students, under the tutorship of 'Schweizer Jugendforscht', an organisation which supports the scientific activities of very talented young people. The organisers chose 'Mission to Jupiter's Moon, Europa' as the general theme for this study week. From 2 to 8 October 2005 several groups of students (between 16 and 19 years old) had to investigate some mission-related questions, ranging from the choice of the orbit and different ways of explor...

  20. Characterizing Volcanic Eruptions on Venus: Some Realistic (?) Scenarios (United States)

    Stofan, E. R.; Glaze, L. S.; Grinspoon, D. H.


    When Pioneer Venus arrived at Venus in 1978, it detected anomalously high concentrations of SO2 at the top of the troposphere, which subsequently declined over the next five years. This decline in SO2 was linked to some sort of dynamic process, possibly a volcanic eruption. Observations of SO2 variability have persisted since Pioneer Venus. More recently, scientists from the Venus Express mission announced that the SPICAV (Spectroscopy for Investigation of Characteristics of the Atmosphere of Venus) instrument had measured varying amounts of SO2 in the upper atmosphere; VIRTIS (Visible and Infrared Thermal Imaging Spectrometer) measured no similar variations in the lower atmosphere (ESA, 4 April, 2008). In addition, Fegley and Prinn stated that venusian volcanoes must replenish SO2 to the atmosphere, or it would react with calcite and disappear within 1.9 my. Fegley and Tremain suggested an eruption rate on the order of approx 1 cubic km/year to maintain atmospheric SO2; Bullock and Grinspoon posit that volcanism must have occurred within the last 20-50 my to maintain the sulfuric acid/water clouds on Venus. The abundance of volcanic deposits on Venus and the likely thermal history of the planet suggest that it is still geologically active, although at rates lower than Earth. Current estimates of resurfacing rates range from approx 0.01 cubic km/yr to approx 2 cubic km/yr. Demonstrating definitively that Venus is still volcanically active, and at what rate, would help to constrain models of evolution of the surface and interior, and help to focus future exploration of Venus.

  1. Geology of Venus

    International Nuclear Information System (INIS)

    Basilevsky, A.T.; Head, J.W. III.


    This paper summarizes the emerging picture of the surface of Venus provided by high-resolution earth-based radar telescopes and orbital radar altimetry and imaging systems. The nature and significance of the geological processes operating there are considered. The types of information needed to complete the picture are addressed. 71 references

  2. Noradrenaline increases the expression and release of Hsp72 by human neutrophils. (United States)

    Giraldo, E; Multhoff, G; Ortega, E


    The blood concentration of extracellular 72kDa heat shock protein (eHsp72) increases under conditions of stress, including intense exercise. However, the signal(s), source(s), and secretory pathways in its release into the bloodstream have yet to be clarified. The aim of the present study was to evaluate the role of noradrenaline (NA) as a stress signal on the expression and release of Hsp72 by circulating neutrophils (as a source), all within a context of the immunophysiological regulation during exercise-induced stress in sedentary and healthy young (21-26years) women. The expression of Hsp72 on the surface of isolated neutrophils was determined by flow cytometry, and its release by cultured isolated neutrophils was determined by ELISA. Incubation with cmHsp70-FITC showed that neutrophils express Hsp72 on their surface under basal conditions. In addition, cultured isolated neutrophils (37 degrees C and 5% CO(2)) also released Hsp72 under basal conditions, with this release increasing from 10min to 24h in the absence of cell damage. NA at 10(-9)-10(-5)M doubled the percentage of neutrophils expressing Hsp72 after 60min and 24h incubation. NA also stimulated (by about 20%) the release of Hsp72 after 10min of incubation. (1) Hsp72 is expressed on the surface of isolated neutrophils under basal conditions, and this expression is augmented by NA. (2) Isolated neutrophils can also release Hsp72 under cultured basal conditions in the absence of cell death, and NA can increase this release. These results may contribute to confirming the hypothesis that NA can act as a "stress signal" for the increased eHsp72 in the context of exercise stress, with a role for neutrophils as a source for the expression and, to a lesser degree, the release of Hsp72 after activation by NA. Copyright 2010 Elsevier Inc. All rights reserved.

  3. Sampling the Cloudtop Region on Venus (United States)

    Limaye, Sanjay; Ashish, Kumar; Alam, Mofeez; Landis, Geoffrey; Widemann, Thomas; Kremic, Tibor


    The details of the cloud structure on Venus continue to be elusive. One of the main questions is the nature and identity of the ultraviolet absorber(s). Remote sensing observations from Venus Express have provided much more information about the ubiquitous cloud cover on Venus from both reflected and emitted radiation from Venus Monitoring Camera (VMC) and Visible InfraRed Imaging Spectrometer (VIRTIS) observations. Previously, only the Pioneer Venus Large Probe has measured the size distribution of the cloud particles, and other probes have measured the bulk optical properties of the cloud cover. However, the direct sampling of the clouds has been possible only below about 62 km, whereas the recent Venus Express observations indicate that the cloud tops extend from about 75 km in equatorial region to about 67 km in polar regions. To sample the cloud top region of Venus, other platforms are required. An unmanned aerial vehicle (UAV) has been proposed previously (Landis et al., 2002). Another that is being looked into, is a semi-buoyant aerial vehicle that can be powered using solar cells and equipped with instruments to not only sample the cloud particles, but also to make key atmospheric measurements - e.g. atmospheric composition including isotopic abundances of noble and other gases, winds and turbulence, deposition of solar and infrared radiation, electrical activity. The conceptual design of such a vehicle can carry a much more massive payload than any other platform, and can be controlled to sample different altitudes and day and night hemispheres. Thus, detailed observations of the surface using a miniature Synthetic Aperture Radar are possible. Data relay to Earth will need an orbiter, preferably in a low inclination orbit, depending on the latitude region selected for emphasis. Since the vehicle has a large surface area, thermal loads on entry are low, enabling deployment without the use of an aeroshell. Flight characteristics of such a vehicle have been

  4. Solar Wind Interaction and Impact on the Venus Atmosphere (United States)

    Futaana, Yoshifumi; Stenberg Wieser, Gabriella; Barabash, Stas; Luhmann, Janet G.


    Venus has intrigued planetary scientists for decades because of its huge contrasts to Earth, in spite of its nickname of "Earth's Twin". Its invisible upper atmosphere and space environment are also part of the larger story of Venus and its evolution. In 60s to 70s, several missions (Venera and Mariner series) explored Venus-solar wind interaction regions. They identified the basic structure of the near-Venus space environment, for example, existence of the bow shock, magnetotail, ionosphere, as well as the lack of the intrinsic magnetic field. A huge leap in knowledge about the solar wind interaction with Venus was made possible by the 14-year long mission, Pioneer Venus Orbiter (PVO), launched in 1978. More recently, ESA's probe, Venus Express (VEX), was inserted into orbit in 2006, operated for 8 years. Owing to its different orbit from that of PVO, VEX made unique measurements in the polar and terminator regions, and probed the near-Venus tail for the first time. The near-tail hosts dynamic processes that lead to plasma energization. These processes in turn lead to the loss of ionospheric ions to space, slowly eroding the Venusian atmosphere. VEX carried an ion spectrometer with a moderate mass-separation capability and the observed ratio of the escaping hydrogen and oxygen ions in the wake indicates the stoichiometric loss of water from Venus. The structure and dynamics of the induced magnetosphere depends on the prevailing solar wind conditions. VEX studied the response of the magnetospheric system on different time scales. A plethora of waves was identified by the magnetometer on VEX; some of them were not previously observed by PVO. Proton cyclotron waves were seen far upstream of the bow shock, mirror mode waves were observed in magnetosheath and whistler mode waves, possibly generated by lightning discharges were frequently seen. VEX also encouraged renewed numerical modeling efforts, including fluid-type of models and particle-fluid hybrid type of models

  5. Lightning on Venus (United States)

    Scarf, F. L.


    On the night side of Venus, the plasma wave instrument on the Pioneer-Venus Orbiter frequently detects strong and impulsive low-frequency noise bursts when the local magnetic field is strong and steady and when the field is oriented to point down to the ionosphere. The signals have characteristics of lightning whistlers, and an attempt was made to identify the sources by tracing rays along the B-field from the Orbiter down toward the surface. An extensive data set strongly indicates a clustering of lightning sources near the Beta and Phoebe Regios, with additional significant clustering near the Atla Regio at the eastern edge of Aphrodite Terra. These results suggest that there are localized lightning sources at or near the planetary surface.

  6. Venus gravity fields (United States)

    Sjogren, W. L.; Ananda, M.; Williams, B. G.; Birkeland, P. W.; Esposito, P. S.; Wimberly, R. N.; Ritke, S. J.


    Results of Pioneer Venus Orbiter observations concerning the gravity field of Venus are presented. The gravitational data was obtained from reductions of Doppler radio tracking data for the Orbiter, which is in a highly eccentric orbit with periapsis altitude varying from 145 to 180 km and nearly fixed periapsis latitude of 15 deg N. The global gravity field was obtained through the simultaneous estimation of the orbit state parameters and gravity coefficients from long-period variations in orbital element rates. The global field has been described with sixth degree and order spherical harmonic coefficients, which are capable of resolving the three major topographical features on Venus. Local anomalies have been mapped using line-of-sight accelerations derived from the Doppler residuals between 40 deg N and 10 deg S latitude at approximately 300 km spatial resolution. Gravitational data is observed to correspond to topographical data obtained by radar altimeter, with most of the gravitational anomalies about 20-30 milligals. Simulations evaluating the isostatic states of two topographic features indicate that at least partial isostasy prevails, with the possibility of complete compensation.

  7. The various contributions in Venus rotation rate and LOD (United States)

    Cottereau, L.; Rambaux, N.; Lebonnois, S.; Souchay, J.


    Context. Thanks to the Venus Express Mission, new data on the properties of Venus could be obtained, in particular concerning its rotation. Aims: In view of these upcoming results, the purpose of this paper is to determine and compare the major physical processes influencing the rotation of Venus and, more particularly, the angular rotation rate. Methods: Applying models already used for Earth, the effect of the triaxiality of a rigid Venus on its period of rotation are computed. Then the variations of Venus rotation caused by the elasticity, the atmosphere, and the core of the planet are evaluated. Results: Although the largest irregularities in the rotation rate of the Earth on short time scales are caused by its atmosphere and elastic deformations, we show that the irregularities for Venus are dominated by the tidal torque exerted by the Sun on its solid body. Indeed, as Venus has a slow rotation, these effects have a large amplitude of two minutes of time (mn). These variations in the rotation rate are greater than the one induced by atmospheric wind variations that can reach 25-50 s of time (s), depending on the simulation used. The variations due to the core effects that vary with its size between 3 and 20 s are smaller. Compared to these effects, the influence of the elastic deformation caused by the zonal tidal potential is negligible. Conclusions: As the variations in the rotation of Venus reported here are close to 3 mn peak to peak, they should influence past, present, and future observations, thereby providing further constraints on the planet's internal structure and atmosphere.

  8. The Plains of Venus (United States)

    Sharpton, V. L.


    Volcanic plains units of various types comprise at least 80% of the surface of Venus. Though devoid of topographic splendor and, therefore often overlooked, these plains units house a spectacular array of volcanic, tectonic, and impact features. Here I propose that the plains hold the keys to understanding the resurfacing history of Venus and resolving the global stratigraphy debate. The quasi-random distribution of impact craters and the small number that have been conspicuously modified from the outside by plains-forming volcanism have led some to propose that Venus was catastrophically resurfaced around 725×375 Ma with little volcanism since. Challenges, however, hinge on interpretations of certain morphological characteristics of impact craters: For instance, Venusian impact craters exhibit either radar dark (smooth) floor deposits or bright, blocky floors. Bright floor craters (BFC) are typically 100-400 m deeper than dark floor craters (DFC). Furthermore, all 58 impact craters with ephemeral bright ejecta rays and/or distal parabolic ejecta patterns have bright floor deposits. This suggests that BFCs are younger, on average, than DFCs. These observations suggest that DFCs could be partially filled with lava during plains emplacement and, therefore, are not strictly younger than the plains units as widely held. Because the DFC group comprises ~80% of the total crater population on Venus the recalculated emplacement age of the plains would be ~145 Ma if DFCs are indeed volcanically modified during plains formation. Improved image and topographic data are required to measure stratigraphic and morphometric relationships and resolve this issue. Plains units are also home to an abundant and diverse set of volcanic features including steep-sided domes, shield fields, isolated volcanoes, collapse features and lava channels, some of which extend for 1000s of kilometers. The inferred viscosity range of plains-forming lavas, therefore, is immense, ranging from the

  9. The VENUS detector at TRISTAN

    International Nuclear Information System (INIS)

    Sugimoto, Shojiro


    The design of the VENUS detector is described. In this paper, emphasis is placed on the central tracking chamber and the electromagnetic shower calorimeters. Referring to computer simulations and test measurements with prototypes, the expected performance of our detector system is discussed. The contents are, for the most part, taken from the VENUS proposal /2/. (author)

  10. Parallel expression of synaptophysin and evoked neurotransmitter release during development of cultured neurons

    DEFF Research Database (Denmark)

    Ehrhart-Bornstein, M; Treiman, M; Hansen, Gert Helge


    Primary cultures of GABAergic cerebral cortex neurons and glutamatergic cerebellar granule cells were used to study the expression of synaptophysin, a synaptic vesicle marker protein, along with the ability of each cell type to release neurotransmitter upon stimulation. The synaptophysin expression...... by quantitative immunoblotting and light microscope immunocytochemistry, respectively. In both cell types, a close parallelism was found between the temporal pattern of development in synaptophysin expression and neurotransmitter release. This temporal pattern differed between the two types of neurons....... The cerebral cortex neurons showed a biphasic time course of increase in synaptophysin content, paralleled by a biphasic pattern of development in their ability to release [3H]GABA in response to depolarization by glutamate or elevated K+ concentrations. In contrast, a monophasic, approximately linear increase...

  11. Chemical Weathering on Venus (United States)

    Zolotov, Mikhail


    Chemical and phase compositions of Venus's surface could reflect history of gas- and fluid-rock interactions, recent and past climate changes, and a loss of water from the Earth's sister planet. The concept of chemical weathering on Venus through gas-solid type reactions has been established in 1960s after the discovery of hot and dense CO2-rich atmosphere inferred from Earth-based and Mariner 2 radio emission data. Initial works suggested carbonation, hydration, and oxidation of exposed igneous rocks and a control (buffering) of atmospheric gases by solid-gas type chemical equilibria in the near-surface lithosphere. Calcite, quartz, wollastonite, amphiboles, and Fe oxides were considered likely secondary minerals. Since the late 1970s, measurements of trace gases in the sub-cloud atmosphere by Pioneer Venus and Venera entry probes and Earth-based infrared spectroscopy doubted the likelihood of hydration and carbonation. The H2O gas content appeared to be low to allow a stable existence of hydrated and a majority of OH-bearing minerals. The concentration of SO2 was too high to allow the stability of calcite and Ca-rich silicates with respect to sulfatization to CaSO4. In 1980s, the supposed ongoing consumption of atmospheric SO2 to sulfates gained support by the detection of an elevated bulk S content at Venera and Vega landing sites. The induced composition of the near-surface atmosphere implied oxidation of ferrous minerals to magnetite and hematite, consistent with the infrared reflectance of surface materials. The likelihood of sulfatization and oxidation has been illustrated in modeling experiments at simulated Venus conditions. Venus's surface morphology suggests that hot surface rocks and fines of mainly mafic composition contacted atmospheric gases during several hundreds of millions years since a global volcanic resurfacing. Some exposed materials could have reacted at higher and lower temperatures in a presence of diverse gases at different altitudinal

  12. VENUS Ranging Study (United States)


    Majesté la Reine (en droit du Canada), telle que réprésentée par le ministre de la Défense nationale, 2014 Abstract The underwater acoustic propagation...50 km des capteurs sous-marins situés aux nœuds du réseau VENUS dont les données acoustiques et sismiques sont accessibles au public sur Internet...Southwest British Columbia, Geophysical Journal International , 170(2), 800–812. [15] Hamilton, E. L. (1979), Vp/Vs and Poisson’s ratios in marine

  13. RRE-dependent HIV-1 Env RNA effects on Gag protein expression, assembly and release

    International Nuclear Information System (INIS)

    López, Claudia S.; Sloan, Rachel; Cylinder, Isabel; Kozak, Susan L.; Kabat, David; Barklis, Eric


    The HIV-1 Gag proteins are translated from the full-length HIV-1 viral RNA (vRNA), whereas the envelope (Env) protein is translated from incompletely spliced Env mRNAs. Nuclear export of vRNAs and Env mRNAs is mediated by the Rev accessory protein which binds to the rev-responsive element (RRE) present on these RNAs. Evidence has shown there is a direct or indirect interaction between the Gag protein, and the cytoplasmic tail (CT) of the Env protein. Our current work shows that env gene expression impacts HIV-1 Gag expression and function in two ways. At the protein level, full-length Env expression altered Gag protein expression, while Env CT-deletion proteins did not. At the RNA level, RRE-containing Env mRNA expression reduced Gag expression, processing, and virus particle release from cells. Our results support models in which Gag is influenced by the Env CT, and Env mRNAs compete with vRNAs for nuclear export. - Highlights: • At the protein level, full-length HIV-1 Env alters Gag protein expression. • HIV-1 Env RNA expression reduces Gag levels and virus release. • Env RNA effects on Gag are dependent on the RRE. • RRE-containing Env RNAs compete with vRNAs for nuclear export

  14. Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain.

    Directory of Open Access Journals (Sweden)

    Fiona A Martin

    Full Text Available Thrombomodulin (TM, an integral membrane glycoprotein expressed on the lumenal surface of vascular endothelial cells, promotes anti-coagulant and anti-inflammatory properties. Release of functional TM from the endothelium surface into plasma has also been reported. Much is still unknown however about how endothelial TM is regulated by physiologic hemodynamic forces (and particularly cyclic strain intrinsic to endothelial-mediated vascular homeostasis.This study employed human aortic endothelial cells (HAECs to investigate the effects of equibiaxial cyclic strain (7.5%, 60 cycles/min, 24 hrs, and to a lesser extent, laminar shear stress (10 dynes/cm2, 24 hrs, on TM expression and release. Time-, dose- and frequency-dependency studies were performed.Our initial studies demonstrated that cyclic strain strongly downregulated TM expression in a p38- and receptor tyrosine kinase-dependent manner. This was in contrast to the upregulatory effect of shear stress. Moreover, both forces significantly upregulated TM release over a 48 hr period. With continuing focus on the cyclic strain-induced TM release, we noted both dose (0-7.5% and frequency (0.5-2.0 Hz dependency, with no attenuation of strain-induced TM release observed following inhibition of MAP kinases (p38, ERK-1/2, receptor tyrosine kinase, or eNOS. The concerted impact of cyclic strain and inflammatory mediators on TM release from HAECs was also investigated. In this respect, both TNFα (100 ng/ml and ox-LDL (10-50 µg/ml appeared to potentiate strain-induced TM release. Finally, inhibition of neither MMPs (GM6001 nor rhomboids (3,4-dichloroisocoumarin had any effect on strain-induced TM release. However, significantly elevated levels (2.1 fold of TM were observed in isolated microparticle fractions following 7.5% strain for 24 hrs.A preliminary in vitro investigation into the effects of cyclic strain on TM in HAECs is presented. Physiologic cyclic strain was observed to downregulate TM

  15. Venus - Phoebe Region (United States)


    This Magellan radar image is of part of the Phoebe region of Venus. It is a mosaic of parts of revolutions 146 and 147 acquired in the first radar test on Aug. 16, 1990. The area in the image is located at 291 degrees east longitude, 19 degrees south latitude. The image shows an area 30 kilometers (19.6 miles) wide and 76 km (47 miles) long. On the basis of Pioneer Venus and Arecibo data, it is known that two major rift zones occur in southern Phoebe Regio and that they terminate at about 20 to 25 degrees south latitude, about 2,000 km (1,240 miles) apart. This image is of an area just north of the southern end of the western rift zone. The region is characterized by a complex geologic history involving both volcanism and faulting. Several of the geologic units show distinctive overlapping or cross cutting relationships that permit identification and separation of geologic events and construction of the geologic history of the region. The oldest rocks in this image form the complexly deformed and faulted, radar bright, hilly terrain in the northern half. Faults of a variety of orientations are observed. A narrow fault trough (about one-half to one km (three tenths to six tenths of a mile) wide is seen crossing the bright hills near the lower part in the middle of the image. This is one of the youngest faults in the faulted, hilly unit as it is seen to cut across many other structures. The fault trough in turn appears to be embayed and flooded by the darker plains that appear in the south half of the image. These plains are interpreted to be of volcanic origin. The dark plains may be formed of a complex of overlapping volcanic flows. For example, the somewhat darker region of plains in the lower left (southwest) corner of the image may be a different age series of plains forming volcanic lava flows. Finally, the narrow bright line crossing the image in its lower part is interpreted to be a fault which cross cuts both plains units and is thus the youngest event in

  16. Laying bare Venus' dark secrets

    International Nuclear Information System (INIS)

    Allen, D.A.


    Ground-based IR observations of the dark side of Venus obtained in 1983 and 1985 with the Anglo-Australian Telescope are studied. An IR spectrum of Venus' dark side is analyzed. It is observed that the Venus atmosphere is composed of CO and radiation escapes only at 1.74 microns and 2.2 to 2.4 microns. The possible origin of the radiation, either due to absorbed sunlight or escaping thermal radiation, was investigated. These two hypotheses were eliminated, and it is proposed that the clouds of Venus are transparent and the radiation originates from the same stratum as the brighter portions but is weakened by the passage through the upper layer. The significance of the observed dark side markings is discussed

  17. Venus Suface Sampling and Analysis (United States)

    National Aeronautics and Space Administration — This effort is developing the technology to transfer particulate samples from a Venus drill (being developed by Honeybee Robotics in a Phase 2 Small Business...

  18. Short Large-Amplitude Magnetic Structures (SLAMS) at Venus (United States)

    Collinson, G. A.; Wilson, L. B.; Sibeck, D. G.; Shane, N.; Zhang, T. L.; Moore, T. E.; Coates, A. J.; Barabash, S.


    We present the first observation of magnetic fluctuations consistent with Short Large-Amplitude Magnetic Structures (SLAMS) in the foreshock of the planet Venus. Three monolithic magnetic field spikes were observed by the Venus Express on the 11th of April 2009. The structures were approx.1.5->11s in duration, had magnetic compression ratios between approx.3->6, and exhibited elliptical polarization. These characteristics are consistent with the SLAMS observed at Earth, Jupiter, and Comet Giacobini-Zinner, and thus we hypothesize that it is possible SLAMS may be found at any celestial body with a foreshock.

  19. Mantle plumes on Venus revisited (United States)

    Kiefer, Walter S.


    The Equatorial Highlands of Venus consist of a series of quasicircular regions of high topography, rising up to about 5 km above the mean planetary radius. These highlands are strongly correlated with positive geoid anomalies, with a peak amplitude of 120 m at Atla Regio. Shield volcanism is observed at Beta, Eistla, Bell, and Atla Regiones and in the Hathor Mons-Innini Mons-Ushas Mons region of the southern hemisphere. Volcanos have also been mapped in Phoebe Regio and flood volcanism is observed in Ovda and Thetis Regiones. Extensional tectonism is also observed in Ovda and Thetis Regiones. Extensional tectonism is also observed in many of these regions. It is now widely accepted that at least Beta, Atla, Eistla, and Bell Regiones are the surface expressions of hot, rising mantel plumes. Upwelling plumes are consistent with both the volcanism and the extensional tectonism observed in these regions. The geoid anomalies and topography of these four regions show considerable variation. Peak geoid anomalies exceed 90 m at Beta and Atla, but are only 40 m at Eistla and 24 m at Bell. Similarly, the peak topography is greater at Beta and Atla than at Eistla and Bell. Such a range of values is not surprising because terrestrial hotspot swells also have a side range of geoid anomalies and topographic uplifts. Kiefer and Hager used cylindrical axisymmetric, steady-state convection calculations to show that mantle plumes can quantitatively account for both the amplitude and the shape of the long-wavelength geoid and topography at Beta and Atla. In these models, most of the topography of these highlands is due to uplift by the vertical normal stress associated with the rising plume. Additional topography may also be present due to crustal thickening by volcanism and crustal thinning by rifting. Smrekar and Phillips have also considered the geoid and topography of plumes on Venus, but they restricted themselves to considering only the geoid-topography ratio and did not

  20. Rate of volcanism on Venus

    International Nuclear Information System (INIS)

    Fegley, B. Jr.; Prinn, R.G.


    The maintenance of the global H 2 SO 4 clouds on Venus requires volcanism to replenish the atmospheric SO 2 which is continually being removed from the atmosphere by reaction with calcium minerals on the surface of Venus. The first laboratory measurements of the rate of one such reaction, between SO 2 and calcite (CaCO 3 ) to form anhydrite (CaSO 4 ), are reported. If the rate of this reaction is representative of the SO 2 reaction rate at the Venus surface, then we estimate that all SO 2 in the Venus atmosphere (and thus the H 2 SO 4 clouds) will be removed in 1.9 million years unless the lost SO 2 is replenished by volcanism. The required rate of volcanism ranges from about 0.4 to about 11 cu km of magma erupted per year, depending on the assumed sulfur content of the erupted material. If this material has the same composition as the Venus surface at the Venera 13, 14 and Vega 2 landing sites, then the required rate of volcanism is about 1 cu km per year. This independent geochemically estimated rate can be used to determine if either (or neither) of the two discordant (2 cu km/year vs. 200 to 300 cu km/year) geophysically estimated rates is correct. The geochemically estimated rate also suggests that Venus is less volcanically active than the Earth

  1. Role of GABA Release From Leptin Receptor-Expressing Neurons in Body Weight Regulation (United States)

    Xu, Yuanzhong; O'Brien, William G.; Lee, Cheng-Chi; Myers, Martin G.


    It is well established that leptin regulates energy balance largely through isoform B leptin receptor-expressing neurons (LepR neurons) in the brain and that leptin activates one subset of LepR neurons (leptin-excited neurons) while inhibiting the other (leptin-inhibited neurons). However, the neurotransmitters released from LepR neurons that mediate leptin action in the brain are not well understood. Previous results demonstrate that leptin mainly acts on γ-aminobutyric acid (GABA)ergic neurons to reduce body weight, and that leptin activates proopiomelanocortin neuron activity by reducing GABA release onto these neurons, suggesting a body weight-promoting role for GABA released from leptin-inhibited neurons. To directly examine the role of GABA release from LepR neurons in body weight regulation, mice with disruption of GABA release specifically from LepR neurons were generated by deletion of vesicular GABA transporter in LepR neurons. Interestingly, these mice developed mild obesity on chow diet and were sensitive to diet-induced obesity, which were associated with higher food intake and lower energy expenditure. Moreover, these mice showed blunted responses in both food intake and body weight to acute leptin administration. These results demonstrate that GABA plays an important role in mediating leptin action. In combination with the previous studies that leptin reduces GABA release onto proopiomelanocortin neurons through leptin-inhibited neurons and that disruption of GABA release from agouti gene-related protein neurons, one subset of LepR-inhibited neurons, leads to a lean phenotype, our results suggest that, under our experimental conditions, GABA release from leptin-excited neuron dominates over leptin-inhibited ones. PMID:22334723

  2. Physiological characteristics and related gene expression of after-ripening on seed dormancy release in rice. (United States)

    Du, W; Cheng, J; Cheng, Y; Wang, L; He, Y; Wang, Z; Zhang, H


    After-ripening is a common method used for dormancy release in rice. In this study, the rice variety Jiucaiqing (Oryza sativa L. subsp. japonica) was used to determine dormancy release following different after-ripening times (1, 2 and 3 months). Germination speed, germination percentage and seedling emergence increased with after-ripening; more than 95% germination and 85% seedling emergence were observed following 1 month of after-ripening within 10 days of imbibition, compared with rice dormancy release. Dormancy release by after-ripening is mainly correlated with a rapid decline in ABA content and increase in IAA content during imbibition. Subsequently, GA(1)/ABA, GA(7)/ABA, GA(12)/ABA, GA(20)/ABA and IAA/ABA ratios significantly increased, while GA(3)/ABA, GA(4)/ABA and GAs/IAA ratio significantly decreased in imbibed seeds following 3 months of after-ripening, thereby altering α-amylase activity during seed germination. Peak α-amylase activity occurred at an earlier germination stage in after-ripened seeds than in freshly harvested seeds. Expression of ABA, GA and IAA metabolism genes and dormancy-related genes was regulated by after-ripening time upon imbibition. Expression of OsCYP707A5, OsGA2ox1, OsGA2ox2, OsGA2ox3, OsILR1, OsGH3-2, qLTG3-1 and OsVP1 increased, while expression of Sdr4 decreased in imbibed seeds following 3 months of after-ripening. Dormancy release through after-ripening might be involved in weakening tissues covering the embryo via qLTG3-1 and decreased ABA signalling and sensitivity via Sdr4 and OsVP1. © 2015 German Botanical Society and The Royal Botanical Society of the Netherlands.

  3. Arabidopsis MAP Kinase 4 regulates gene expression via transcription factor release in the nucleus

    DEFF Research Database (Denmark)

    Qiu, Jin-Long; Fiil, Berthe Katrine; Petersen, Klaus


    kinase 4 (MPK4) exists in nuclear complexes with the WRKY33 transcription factor. This complex depends on the MPK4 substrate MKS1. Challenge with Pseudomonas syringae or flagellin leads to the activation of MPK4 and phosphorylation of MKS1. Subsequently, complexes with MKS1 and WRKY33 are released from...... MPK4, and WRKY33 targets the promoter of PHYTOALEXIN DEFICIENT3 (PAD3) encoding an enzyme required for the synthesis of antimicrobial camalexin. Hence, wrky33 mutants are impaired in the accumulation of PAD3 mRNA and camalexin production upon infection. That WRKY33 is an effector of MPK4 is further...... supported by the suppression of PAD3 expression in mpk4-wrky33 double mutant backgrounds. Our data establish direct links between MPK4 and innate immunity and provide an example of how a plant MAP kinase can regulate gene expression by releasing transcription factors in the nucleus upon activation....

  4. Growth hormone-releasing factor induces c-fos expression in cultured primary pituitary cells

    DEFF Research Database (Denmark)

    Billestrup, Nils; Mitchell, R L; Vale, W


    GH-releasing factor (GRF) and somatostatin regulates the secretion and biosynthesis of GH as well as the proliferation of GH-producing cells. In order to further characterize the mitogenic effect of GRF, we studied the expression of the proto-oncogene c-fos in primary pituitary cells. Maximal...... induction of c-fos mRNA was observed 20-60 min after stimulation with 5 nM GRF, returning to basal levels after 2 h. Somatostatin-14 (5 nM) partially inhibited the GRF induced c-fos expression. Forskolin and phorbol 12, 13 dibutyrate induced c-fos gene in cultured primary pituitary cells with similar...

  5. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta

    International Nuclear Information System (INIS)

    Robinson, B.G.; Emanuel, R.L.; Frim, D.M.; Majzoub, J.A.


    Primary cultures of purified human cytotrophoblasts have been used to examine the expression of the corticotropin-releasing hormone (CRH) gene in placenta. The authors report here that glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta. This stimulation is in contrast to the glucocorticoid suppression of CRH expression in hypothalamus. The positive regulation of CRH by glucocorticoids suggests that the rise in CRH preceding parturition could result from the previously described rise in fetal glucocorticoids. Furthermore, this increase in placental CRH could stimulate, via adrenocorticotropic hormone, a further rise in fetal glucocorticoids, completing a positive feedback loop that would be terminated by delivery

  6. Expression and roles of pannexins in ATP release in the pituitary gland. (United States)

    Li, Shuo; Bjelobaba, Ivana; Yan, Zonghe; Kucka, Marek; Tomic, Melanija; Stojilkovic, Stanko S


    Pannexins are a newly discovered three-member family of proteins expressed in the brain and peripheral tissues that belong to the superfamily of gap junction proteins. However, in mammals pannexins do not form gap junctions, and their expression and function in the pituitary gland have not been studied. Here we show that the rat pituitary gland expresses mRNA and protein transcripts of pannexins 1 and 2 but not pannexin 3. Pannexin 1 was more abundantly expressed in the anterior lobe, whereas pannexin 2 was more abundantly expressed in the intermediate and posterior pituitary. Pannexin 1 was identified in corticotrophs and a fraction of somatotrophs, the S100-positive pituicytes of the posterior pituitary and AtT-20 (mouse pituitary adrenocorticotropin-secreting cells) and rat immortalized pituitary cells secreting prolactin, whereas pannexin 2 was detected in the S100-positive folliculostellate cells of the anterior pituitary, melanotrophs of the intermediate lobe, and vasopressin-containing axons and nerve endings in the posterior lobe. Overexpression of pannexins 1 and 2 in AtT-20 pituitary cells enhanced the release of ATP in the extracellular medium, which was blocked by the gap junction inhibitor carbenoxolone. Basal ATP release in At-T20 cells was also suppressed by down-regulating the expression of endogenous pannexin 1 but not pannexin 2 with their short interfering RNAs. These results indicate that pannexins may provide a pathway for delivery of ATP, which is a native agonist for numerous P2X cationic channels and G protein-coupled P2Y receptors endogenously expressed in the pituitary gland.

  7. Results from VENUS

    International Nuclear Information System (INIS)

    Ogawa, K.


    Recent results from VENUS experiments on e + e - reactions at energies between 52 and 60.8 GeV are presented. The R-values, the ratio of the total hadronic cross section to that of μ pair production, look slightly high within the present energy region. To understand this observation, a detailed study was carried out on the production of a heavy quark with |Q|=e/3. By using a next-to-leading log. approximation, the QCD cut-off parameter, Λ MS , was obtained as being Λ MS =208 MeV(+80MeV, -62MeV). The differential cross sections for e + e - → e + e - , γγ, μ + μ - , and τ + τ - were found to be consistent with predictions of the standard model. The average charge asymmetry for e + e - → qq-bar was also measured and found to be consistent with the prediction of the standard model. No evidence was observed indicating new particle production. No single photon production was observed and the upper limit of the number of light neutrino types was set to be N ν < 17.8 (90 % CL). (author)

  8. Venus project : experimentation at ENEA's pilot site

    International Nuclear Information System (INIS)

    Bargellini, M.L.; Fontana, F.; Niccolai, L.; Scavino, G.; Mancini, R.; Levialdi, S.


    The document describes the ENEA's (Italian Agency for New Technologies, Energy and the Environment) experience in the Venus Project (Esprit III 6398). Venus is an advanced visual interface based on icon representation that permits to end-user to inquiry databases. VENUS interfaces to ENEA's databases: cometa materials Module, Cometa Laboratories Module and European Programs. This report contents the results of the experimentation and of the validation carried out in ENEA's related to the Venus generations. Moreover, the description of the architecture, the user requirements syntesis and the validation methodology of the VENUS systems have been included

  9. Effects of propofol on lipopolysaccharide-induced expression and release of HMGB1 in macrophages

    Energy Technology Data Exchange (ETDEWEB)

    Wang, T.; Wei, X.Y.; Liu, B.; Wang, L.J.; Jiang, L.H. [Department of Anesthesiology, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou (China)


    This study aimed to determine the effects of different concentrations of propofol (2,6-diisopropylphenol) on lipopolysaccharide (LPS)-induced expression and release of high-mobility group box 1 protein (HMGB1) in mouse macrophages. Mouse macrophage cell line RAW264.7 cells were randomly divided into 5 treatment groups. Expression levels of HMGB1 mRNA were detected using RT-PCR, and cell culture supernatant HMGB1 protein levels were detected using enzyme-linked immunosorbent assay (ELISA). Translocation of HMGB1 from the nucleus to the cytoplasm in macrophages was observed by Western blotting and activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in the nucleus was detected using ELISA. HMGB1 mRNA expression levels increased significantly in the cell culture supernatant and in cells after 24 h of stimulating RAW264.7 cells with LPS (500 ng/mL). However, HMGB1 mRNA expression levels in the P2 and P3 groups, which received 500 ng/mL LPS with 25 or 50 μmol/mL propofol, respectively, were significantly lower than those in the group receiving LPS stimulation (P<0.05). After stimulation by LPS, HMGB1 protein levels were reduced significantly in the nucleus but were increased in the cytoplasm (P<0.05). Simultaneously, the activity of NF-κB was enhanced significantly (P<0.05). After propofol intervention, HMGB1 translocation from the nucleus to the cytoplasm and NF-κB activity were inhibited significantly (each P<0.05). Thus, propofol can inhibit the LPS-induced expression and release of HMGB1 by inhibiting HMGB1 translocation and NF-κB activity in RAW264.7 cells, suggesting propofol may be protective in patients with sepsis.

  10. The lower expression of gonadotropin-releasing hormone receptor associated with poor prognosis in gastric cancer (United States)

    Lu, Mingzhu; Zhu, Jing; Ling, Yang; Shi, Wenping; Zhang, Changsong; Wu, Haorong


    Aims: Expression of gonadotropin-releasing hormone receptor (GnRHR) has been demonstrated in a number of malignancies. The aim is to investigate the expression of GnRHR and prognosis in gastric cancer. Methods and materials: GnRHR mRNA was examined in tumor and non-tumor tissues from 48 gastric cancer patients by Real-time PCR. The GnRHR protein expression was performed by immunohistochemical analysis. Results: The expression of GnRHR mRNA was higher (mean ± SD, -10.06 ± 1.28) in gastric tumor tissues than matched non-tumor tissues (mean ± SD, -12.43 ± 1.33). GnRHR mRNA expression was associated with lymph node metastasis, distant metastasis, and TNM stage. We found the decreased expression of GnRHR mRNA were significantly correlated with poor overall survival (P = 0.003). Immunocytochemical staining of GnRHR in tumor tissues showed mainly weak staining (43.48%, 10/23) and moderate staining (21.74%, 5/23) in high GnRHR mRNA patients, and mainly negative staining in low GnRHR mRNA patients. And the staining of GnRHR was not detection in tumor tissues for more than half of gastric patients (52.08%, 25/48). These results implied that the loss of GnRHR protein could be a main event in gastric cancer. Conclusion: The GnRHR expression is very low in gastric cancer, and the loss of GnRHR expression could be a poor prognostic factor, which implied that GnRHR could play an important role in the development of gastric cancer. PMID:26550267

  11. Modulation of Mast Cell Toll-Like Receptor 3 Expression and Cytokines Release by Histamine

    Directory of Open Access Journals (Sweden)

    Guogang Xie


    Full Text Available Background/Aims: As a major inflammatory molecule released from mast cell activation, histamine has been reported to regulate TLRs expression and cytokine production in inflammatory cells present in the microenvironment. In this study, we determined the ability of histamine to modulate TLRs expression and cytokine production in mast cells. Methods: HMC-1 and P815 cells were exposed to various concentrations of histamine in the presence or absence of histamine antagonist for 2, 6 or 16 h. The effect of histamine on the expression of TLR3 protein and mRNA was analyzed by flow cytometry、 RT-PCR and immunofluorescent microscopy. Furthermore, we also examined the effect of histamine on the secretion of MCP-1 and IL-13 from mast cells by ELISA. Results: The amplification of TLR3 mRNA and protein expression in mast cells was observed after incubation with histamine, which was accompanied by increasing secretion of IL-13 and MCP-1 via H1 receptor. The signaling pathways of PI3K/ Akt and Erk1/2/MAPK contributed to these induction effects. Conclusion: These results demonstrate that histamine up-regulates the expression of TLR3 and secretion of IL-13 and MCP-1 in mast cells, thus identifying a new mechanism for the histamine inducing allergic response.

  12. Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression

    International Nuclear Information System (INIS)

    Kim, Hyo-Sup; Noh, Jung-Hyun; Hong, Seung-Hyun; Hwang, You-Cheol; Yang, Tae-Young; Lee, Myung-Shik; Kim, Kwang-Won; Lee, Moon-Kyu


    Peroxisome proliferator-activated receptor (PPAR)-γ is a member of the nuclear receptor superfamily, and its ligands, the thiazolidinediones, might directly stimulate insulin release and insulin synthesis in pancreatic β-cells. In the present study, we examined the effects of rosiglitazone (RGZ) on insulin release and synthesis in pancreatic β-cell (INS-1). Insulin release and synthesis were stimulated by treatment with RGZ for 24 h. RGZ upregulated the expressions of GLUT-2 and glucokinase (GCK). Moreover, it was found that RGZ increased the expression of BETA2/NeuroD gene which could regulate insulin gene expression. These results suggest that RGZ could stimulate the release and synthesis of insulin through the upregulation of GLUT-2, GCK, and BETA2/NeuroD gene expression

  13. A mantle plume model for the Equatorial Highlands of Venus (United States)

    Kiefer, Walter S.; Hager, Bradford H.


    The possibility that the Equatorial Highlands are the surface expressions of hot upwelling mantle plumes is considered via a series of mantle plume models developed using a cylindrical axisymmetric finite element code and depth-dependent Newtonian rheology. The results are scaled by assuming whole mantle convection and that Venus and the earth have similar mantle heat flows. The best model fits are for Beta and Atla. The common feature of the allowed viscosity models is that they lack a pronounced low-viscosity zone in the upper mantle. The shape of Venus's long-wavelength admittance spectrum and the slope of its geoid spectrum are also consistent with the lack of a low-viscosity zone. It is argued that the lack of an asthenosphere on Venus is due to the mantle of Venus being drier than the earth's mantle. Mantle plumes may also have contributed to the formation of some smaller highland swells, such as the Bell and Eistla regions and the Hathor/Innini/Ushas region.

  14. Venus and Mercury as Planets (United States)


    A general evolutionary history of the solar planetary system is given. The previously observed characteristics of Venus and Mercury (i.e. length of day, solar orbit, temperature) are discussed. The role of the Mariner 10 space probe in gathering scientific information on the two planets is briefly described.

  15. Surface and interior of Venus

    Energy Technology Data Exchange (ETDEWEB)

    Masursky, H [U.S. Geological Survey, Flagstaff, Arizona, USA; Kaula, W M [California Univ., Los Angeles (USA); McGill, G E [Massachusetts Univ., Amherst (USA); Pettengill, G H; Shapiro, I I [Massachusetts Inst. of Tech., Cambridge (USA). Dept. of Earth and Planetary Sciences; Phillips, R J [Jet Propulsion Lab., Pasadena, Calif. (USA); Russell, C T [California Univ., Los Angeles (USA). Inst. of Geophysics and Planetary Physics; Schubert, G [California Univ., Los Angeles (USA)


    Present ideas about the surface and interior of Venus are based on data obtained from (1) Earth-based radio and radar: temperature, rotation, shape, and topography; (2) fly-by and orbiting spacecraft: gravity and magnetic fields; and (3) landers: winds, local structure, gamma radiation. Surface features, including large basins, crater-like depressions, and a linear valley, have been recognized from recent ground-based radar images. Pictures of the surface acquired by the USSR's Venera 9 and 10 show abundant boulders and apparent wind erosion. On the Pioneer Venus 1978 Orbiter mission, the radar mapper experiment will determine surface heights, dielectric constant values and small-scale slope values along the sub-orbital track between 50/sup 0/S and 75/sup 0/N. This experiment will also estimate the global shape and provide coarse radar images (40-80 km identification resolution) of part of the surface. Gravity data will be obtained by radio tracking. Maps combining radar altimetry with spacecraft and ground-based images will be made. A fluxgate magnetometer will measure the magnetic fields around Venus. The radar and gravity data will provide clues to the level of crustal differentiation and tectonic activity. The magnetometer will determine the field variations accurately. Data from the combined experiments may constrain the dynamo mechanism; if so, a deeper understanding of both Venus and Earth will be gained.

  16. Venus and Mercury as planets

    International Nuclear Information System (INIS)


    A general evolutionary history of the solar planetary system is given. The previously observed characteristics of Venus and Mercury (i.e. length of day, solar orbit, temperature) are discussed. The role of the Mariner 10 space probe in gathering scientific information on the two planets is briefly described

  17. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. (United States)

    Park, Hyo-Hyun; Lee, Soyoung; Son, Hee-Young; Park, Seung-Bin; Kim, Mi-Sun; Choi, Eun-Ju; Singh, Thoudam S K; Ha, Jeoung-Hee; Lee, Maan-Gee; Kim, Jung-Eun; Hyun, Myung Chul; Kwon, Taeg Kyu; Kim, Yeo Hyang; Kim, Sang-Hyun


    Mast cells participate in allergy and inflammation by secreting inflammatory mediators such as histamine and proinflammatory cytokines. Flavonoids are naturally occurring molecules with antioxidant, cytoprotective, and antiinflammatory actions. However, effect of flavonoids on the release of histamine and proinflammatory mediator, and their comparative mechanism of action in mast cells were not well defined. Here, we compared the effect of six flavonoids (astragalin, fisetin, kaempferol, myricetin, quercetin, and rutin) on the mast cell-mediated allergic inflammation. Fisetin, kaempferol, myricetin, quercetin, and rutin inhibited IgE or phorbol-12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-mediated histamine release in RBL-2H3 cells. These five flavonoids also inhibited elevation of intracellular calcium. Gene expressions and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and IL-8 were assessed in PMACI-stimulated human mast cells (HMC-1). Fisetin, quercetin, and rutin decreased gene expression and production of all the proinflammatory cytokines after PMACI stimulation. Myricetin attenuated TNF-alpha and IL-6 but not IL-1beta and IL-8. Fisetin, myricetin, and rutin suppressed activation of NF-kappaB indicated by inhibition of nuclear translocation of NF-kappaB, NF-kappaB/DNA binding, and NF-kappaB-dependent gene reporter assay. The pharmacological actions of these flavonoids suggest their potential activity for treatment of allergic inflammatory diseases through the down-regulation of mast cell activation.

  18. The cauliflower Orange gene enhances petiole elongation by suppressing expression of eukaryotic release factor 1. (United States)

    Zhou, Xiangjun; Sun, Tian-Hu; Wang, Ning; Ling, Hong-Qing; Lu, Shan; Li, Li


    The cauliflower (Brassica oleracea var. botrytis) Orange (Or) gene affects plant growth and development in addition to conferring β-carotene accumulation. This study was undertaken to investigate the molecular basis for the effects of the Or gene mutation in on plant growth. The OR protein was found to interact with cauliflower and Arabidopsis eukaryotic release factor 1-2 (eRF1-2), a member of the eRF1 family, by yeast two-hybrid analysis and by bimolecular fluorescence complementation (BiFC) assay. Concomitantly, the Or mutant showed reduced expression of the BoeRF1 family genes. Transgenic cauliflower plants with suppressed expression of BoeRF1-2 and BoeRF1-3 were generated by RNA interference. Like the Or mutant, the BoeRF1 RNAi lines showed increased elongation of the leaf petiole. This long-petiole phenotype was largely caused by enhanced cell elongation, which resulted from increased cell length and elevated expression of genes involved in cell-wall loosening. These findings demonstrate that the cauliflower Or gene controls petiole elongation by suppressing the expression of eRF1 genes, and provide new insights into the molecular mechanism of leaf petiole regulation. © 2010 The Authors. New Phytologist © 2010 New Phytologist Trust.

  19. Impairment of Release Site Clearance within the Active Zone by Reduced SCAMP5 Expression Causes Short-Term Depression of Synaptic Release

    Directory of Open Access Journals (Sweden)

    Daehun Park


    Full Text Available Summary: Despite being a highly enriched synaptic vesicle (SV protein and a candidate gene for autism, the physiological function of SCAMP5 remains mostly enigmatic. Here, using optical imaging and electrophysiological experiments, we demonstrate that SCAMP5 plays a critical role in release site clearance at the active zone. Truncation analysis revealed that the 2/3 loop domain of SCAMP5 directly interacts with adaptor protein 2, and this interaction is critical for its role in release site clearance. Knockdown (KD of SCAMP5 exhibited pronounced synaptic depression accompanied by a slower recovery of the SV pool. Moreover, it induced a strong frequency-dependent short-term depression of synaptic release, even under the condition of sufficient release-ready SVs. Super-resolution microscopy further proved the defects in SV protein clearance induced by KD. Thus, reduced expression of SCAMP5 may impair the efficiency of SV clearance at the active zone, and this might relate to the synaptic dysfunction observed in autism. : Park et al. show that SCAMP5 plays an important role in release site clearance during intense neuronal activity. Loss of SCAMP5 results in a traffic jam at release sites, causing aberrant short-term synaptic depression that might be associated with the synaptic dysfunction observed in autism. Keywords: secretory carrier membrane protein, SCAMP5, autism spectrum disorder, adaptor protein 2, release site clearance, presynaptic active zone, short-term depression, endocytosis, super-resolution microscopy

  20. Implications of /sup 36/A excess on Venus

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, M [Tokyo Univ. (Japan). Inst. of Space and Aeronautical Science


    The finding of /sup 36/A excess on Venus by the mass-spectroscopic measurement of the Venus Pioneer appears to endorse the more rapid accretion theory of Venus than the Earth and the secondary origin of the terrestrial atmosphere.

  1. Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3

    Directory of Open Access Journals (Sweden)

    Johannes eZimmermann


    Full Text Available The identity of the vesicle neurotransmitter transporter expressed by a neuron largely corresponds with the primary neurotransmitter that cell releases. However, the vesicular glutamate transporter subtype 3 (VGLUT3 is mainly expressed in non-glutamatergic neurons, including cholinergic, serotonergic, or GABAergic neurons. Though a functional role for glutamate release from these non-glutamatergic neurons has been demonstrated, the interplay between VGLUT3 and the neuron’s characteristic neurotransmitter transporter, particularly in the case of GABAergic neurons, at the synaptic and vesicular level is less clear. In this study, we explore how exogenous expression of VGLUT3 in striatal GABAergic neurons affects the packaging and release of glutamate and GABA in synaptic vesicles. We found that VGLUT3 expression in isolated, autaptic GABAergic neurons leads to action potential evoked release of glutamate. Under these conditions, glutamate and GABA could be packaged together in single vesicles release either spontaneously or asynchronously. However, the presence of glutamate in GABAergic vesicles did not affect uptake of GABA itself, suggesting a lack of synergy in vesicle filling for these transmitters. Finally, we found postsynaptic detection of glutamate released from GABAergic terminals difficult when bona fide glutamatergic synapses were present, suggesting that co-released glutamate cannot induce postsynaptic glutamate receptor clustering.

  2. Glory on Venus and selection among the unknown UV absorbers (United States)

    Petrova, Elena V.


    The comparison of the phase profiles of glories observed on the cloud top of Venus by the Venus Monitoring Camera (Venus Express) and the light-scattering characteristics of sulfuric acid droplets, containing admixtures with a high refractive index, makes it easier to choose between some candidates for the so-called unknown UV absorber in the Venus clouds. Since among the candidates there are materials wetted and not wetted by sulfuric acid, we analyze whether small submicron particles adhered to or embedded into the 1-μm H2SO4 droplets may actually change the glory pattern normally produced by homogeneous spherical particles and what the conditions are, under which the composite particles formed in heterogeneous nucleation may still produce a glory feature. We have found that one of the most frequently considered candidates, sulfur, can hardly be responsible for the contrasts observed at 0.365 μm on the upper clouds, since it is not wetted by sulfuric acid and submicron sulfur particles, serving as condensation nuclei for sulfuric acid, can only adhere to the H2SO4 droplets rather than be enveloped by them. Such droplets decorated by sulfur blobs substantially distort the glory feature characteristic of the scattering by spherical particles or even smooth it at all, while a glory pattern is practically always seen in the images of Venus taken at small phase angles. At the same time, the grains of the other UV absorbers that can be embedded in H2SO4 droplets, e.g., the widely discussed ferric chloride, pose no problem in terms of interpretation of the observations of glory.

  3. Transits of Venus in Public Education and Contemporary Research (United States)

    Pasachoff, J. M.


    Transits of Venus are among the rarest predictable astronomical event that humans can enjoy, and the 2012 transit will be visible by almost all the people on Earth. It is our job as educators to bring out the thrill of being able to see the tiny dot of Venus silhouetted against the solar disk even with just a simple eye-protection filter. My Website at brings together not only historical information about the five previous transits of Venus that were observed through the 20th century--1639, 1761, 1769, 1874, and 1882--but also the scientific work carried out at the 2004 transit and at recent transits of Mercury. Based on space observations of the 1999 transit of Mercury with NASA's Transition Region and Coronal Explorer (TRACE), Glenn Schneider and I provided proof of the contemporary explanation of the black-drop effect as an amalgam of instrumental point-spread and solar limb-darkening [1]. Based on observations of the changes in the total solar irradiance during the transit, we provided an analysis of this solar-system analogue to exoplanet transits [2]. High-resolution (0.5 arcsec pixels) observations of ingress and egress with TRACE during the 2004 transit provided information about the visibility of Venus's atmosphere through its refraction of sunlight, interpreted with Venus Express observations [3]. We anticipate observing the 2012 transit with groundbased facilities of the University of Hawaii at Haleakala, and of the National Solar Observatory at Sacramento Peak, and Kitt Peak, as well as with NASA and JAXA spacecraft, including Solar Dynamics Observatory, ACRIMsat, and Hinode. The Program Group on Public Education on the Occasions of Eclipses and Transits of Commission 46 on Education and Development of the International Astronomical Union, which I chair, looks forward to participating in Education and Public Outreach efforts related to the 2012 transit.

  4. Coupled Photochemical and Condensation Model for the Venus Atmosphere (United States)

    Bierson, Carver; Zhang, Xi; Mendonca, Joao; Liang, Mao-Chang


    Ground based and Venus Express observations have provided a wealth of information on the vertical and latitudinal distribution of many chemical species in the Venus atmosphere [1,2]. Previous 1D models have focused on the chemistry of either the lower [3] or middle atmosphere [4,5]. Photochemical models focusing on the sulfur gas chemistry have also been independent from models of the sulfuric acid haze and cloud formation [6,7]. In recent years sulfur-bearing particles have become important candidates for the observed SO2 inversion above 80 km [5]. To test this hypothesis it is import to create a self-consistent model that includes photochemistry, transport, and cloud condensation.In this work we extend the domain of the 1D chemistry model of Zhang et al. (2012) [5] to encompass the region between the surface to 110 km. This model includes a simple sulfuric acid condensation scheme with gravitational settling. It simultaneously solves for the chemistry and condensation allowing for self-consistent cloud formation. We compare the resulting chemical distributions to observations at all altitudes. We have also validated our model cloud mass against pioneer Venus observations [8]. This updated full atmosphere chemistry model is also being applied in our 2D solver (altitude and altitude). With this 2D model we can model how the latitudinal distribution of chemical species depends on the meridional circulation. This allows us to use the existing chemical observations to place constraints on Venus GCMs [9-11].References: [1] Arney et al., JGR:Planets, 2014 [2] Vandaele et al., Icarus 2017 (pt. 1 & 2) [3] Krasnopolsky, Icarus, 2007 [4] Krasnopolsky, Icarus, 2012 [5] Zhang et al., Icarus 2012 [6] Gao et al., Icarus, 2014 [7] Krasnopolsky, Icarus, 2015 [8] Knollenberg and Hunten, JGR:Space Physics, 1980 [9] Lee et al., JGR:Planets, 2007 [10] Lebonnois et al., Towards Understanding the Climate of Venus, 2013 [11] Mendoncca and Read, Planetary and Space Science, 2016

  5. Differential Gene Expression in Gonadotropin-Releasing Hormone Neurons of Male and Metestrous Female Mice. (United States)

    Vastagh, Csaba; Rodolosse, Annie; Solymosi, Norbert; Farkas, Imre; Auer, Herbert; Sárvári, Miklós; Liposits, Zsolt


    Gonadotropin-releasing hormone (GnRH) neurons play a pivotal role in the regulation of the hypothalamic-pituitary gonadal axis in a sex-specific manner. We hypothesized that the differences seen in reproductive functions of males and females are associated with a sexually dimorphic gene expression profile of GnRH neurons. We compared the transcriptome of GnRH neurons obtained from intact metestrous female and male GnRH-green fluorescent protein transgenic mice. About 1,500 individual GnRH neurons from each sex were sampled with laser capture microdissection followed by whole-transcriptome amplification for gene expression profiling. Under stringent selection criteria (fold change >1.6, adjusted p value 0.01), Affymetrix Mouse Genome 430 PM array analysis identified 543 differentially expressed genes. Sexual dimorphism was most apparent in gene clusters associated with synaptic communication, signal transduction, cell adhesion, vesicular transport and cell metabolism. To validate microarray results, 57 genes were selected, and 91% of their differential expression was confirmed by real-time PCR. Similarly, 88% of microarray results were confirmed with PCR from independent samples obtained by patch pipette harvesting and pooling of 30 GnRH neurons from each sex. We found significant differences in the expression of genes involved in vesicle priming and docking (Syt1, Cplx1), GABAergic (Gabra3, Gabrb3, Gabrg2) and glutamatergic (Gria1, Grin1, Slc17a6) neurotransmission, peptide signaling (Sstr3, Npr2, Cxcr4) and the regulation of intracellular ion homeostasis (Cacna1, Cacnb1, Cacng5, Kcnq2, Kcnc1). The striking sexual dimorphism of the GnRH neuron transcriptome we report here contributes to a better understanding of the differences in cellular mechanisms of GnRH neurons in the two sexes. © 2015 S. Karger AG, Basel.

  6. Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn. (United States)

    Gutierrez-Mecinas, Maria; Watanabe, Masahiko; Todd, Andrew J


    Gastrin-releasing peptide (GRP) and its receptor have been shown to play an important role in the sensation of itch. However, although GRP immunoreactivity has been detected in the spinal dorsal horn, there is debate about whether this originates from primary afferents or local excitatory interneurons. We therefore examined the relation of GRP immunoreactivity to that seen with antibodies that label primary afferent or excitatory interneuron terminals. We tested the specificity of the GRP antibody by preincubating with peptides with which it could potentially cross-react. We also examined tissue from a mouse line in which enhanced green fluorescent protein (EGFP) is expressed under control of the GRP promoter. GRP immunoreactivity was seen in both primary afferent and non-primary glutamatergic axon terminals in the superficial dorsal horn. However, immunostaining was blocked by pre-incubation of the antibody with substance P, which is present at high levels in many nociceptive primary afferents. EGFP+ cells in the GRP-EGFP mouse did not express Pax2, and their axons contained the vesicular glutamate transporter 2 (VGLUT2), indicating that they are excitatory interneurons. In most cases, their axons were also GRP-immunoreactive. Multiple-labelling immunocytochemical studies indicated that these cells did not express either of the preprotachykinin peptides, and that they generally lacked protein kinase Cγ, which is expressed by a subset of the excitatory interneurons in this region. These results show that GRP is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway. They also suggest that the GRP immunoreactivity seen in primary afferents in previous studies may have resulted from cross-reaction of the GRP antibody with substance P or the closely related peptide neurokinin A.

  7. Controlled Autolysis and Enzyme Release in a Recombinant Lactococcal Strain Expressing the Metalloendopeptidase Enterolysin A (United States)

    Hickey, Rita M.; Ross, R. Paul; Hill, Colin


    This study concerns the exploitation of the lytic enzyme enterolysin A (EntL), produced by Enterococcus faecalis strain DPC5280, to elicit the controlled autolysis of starter lactococci. EntL, a cell wall metalloendopeptidase secreted by some E. faecalis strains, can kill a wide range of gram-positive bacteria, including lactococci. The controlled expression of entL, which encodes EntL, was achieved using a nisin-inducible expression system in a lactococcal host. Zymographic analysis of EntL activity demonstrated that active enzyme is produced by the recombinant lactococcal host. Indeed, expression of EntL resulted in almost complete autolysis of the host strain 2 h after induction with nisin. Model cheese experiments using a starter strain in addition to the inducible enterolysin-producing strain showed a 27-fold increase in activity with respect to the release of lactate dehydrogenase in the strain overexpressing EntL, demonstrating the potential of EntL production in large-scale cheese production systems. Indeed, the observation that a wide range of lactic bacteria are sensitive to EntL suggests that EntL-induced autolysis has potential applications with a variety of lactic acid bacteria and could be a basis for probiotic delivery systems. PMID:15006800

  8. Mars is close to venus--female reproductive proteins are expressed in the fat body and reproductive tract of honey bee (Apis mellifera L.) drones. (United States)

    Colonello-Frattini, Nínive Aguiar; Guidugli-Lazzarini, Karina Rosa; Simões, Zilá Luz Paulino; Hartfelder, Klaus


    Vitellogenin (Vg) and lipophorin (Lp) are lipoproteins which play important roles in female reproductive physiology of insects. Both are actively taken up by growing oocytes and especially Vg and its receptor are considered as female-specifically expressed. The finding that the fat body of in honey bee (Apis mellifera) drones synthesizes Vg and is present in hemolymph has long been viewed as a curiosity. The recent paradigm change concerning the role played by Vg in honey bee life history, especially social division of labor, has now led us to investigate whether a physiological constellation similar to that seen in female reproduction may also be represented in the male sex. By means of Western blot analysis we could show that both Vg and Lp are present in the reproductive tract of adult drones, including the accessory (mucus) glands, but apparently are not secreted. Furthermore, we analyzed the transcript levels of the genes encoding these proteins (vg and lp), as well as their putative receptors (Amvgr and Amlpr) in fat body and accessory glands. Whereas lp, vg and Amlpr transcript levels decreased with age in both tissues, Amvgr mRNA levels increased with age in fat body. To our knowledge this is the first report that vitellogenin and its receptor are co-expressed in the reproductive system of a male insect. We interpret these findings as a cross-sexual transfer of a social physiological trait, associated with the rewiring of the juvenile hormone/vitellogenin circuitry that occurred in the female sex of honey bees. Copyright 2010 Elsevier Ltd. All rights reserved.

  9. Methane measurement by the Pioneer Venus large probe neutral mass spectrometer (United States)

    Donahue, T. M.; Hodges, R. R., Jr.


    The Pioneer Venus Large Probe Mass Spectrometer detected a large quantity of methane as it descended below 20 km in the atmosphere of Venus. Terrestrial methane and Xe-136, both originating in the same container and flowing through the same plumbing, were deliberately released inside the mass spectrometer for instrumental reasons. However, the Xe-136 did not exhibit behavior similar to methane during Venus entry, nor did CH4 in laboratory simulations. The CH4 was deuterium poor compared to Venus water and hydrogen. While the inlet to the mass spectrometer was clogged with sulfuric acid droplets, significant deuteration of CH4 and its H2 progeny was observed. Since the only source of deuterium identifiable was water from sulfuric acid, we have concluded that we should correct the HDO/H2O ratio in Venus water from 3.2 x 10-2 to (5 plus or minus 0.7) x 10-2. When the probe was in the lower atmosphere, transfer of deuterium from Venus HDO and HD to CH4 can account quantitatively for the deficiencies recorded in HDO and HD below 10 km, and consequently, the mysterious gradients in water vapor and hydrogen mixing ratios we have reported. The revision in the D/H ratio reduces the mixing ratio of water vapor (and H2) reported previously by a factor of 3.2/5. We are not yet able to say whether the methane detected was atmospheric or an instrumental artifact. If it was atmospheric, its release must have been episodic and highly localized. Otherwise, the large D/H ratio in Venus water and hydrogen could not be maintained.

  10. Venus tectonics: another Earth or another Mars

    International Nuclear Information System (INIS)

    McGill, G.E.


    The presence of presumably primordial large craters has led to the suggestion that Venus may have a thick lithosphere like that of Mars despite its similarities to Earth in size and density. However, crust and upper mantle temperatures on Venus are very likely higher than on Earth so that a dry Venus could have a lithosphere with a thickness similar to that of Earth. If a trace of volatiles is present in the mantle, the lithosphere of Venus could be thinner. Due to the absence of liquid water, erosion and deposition will be much slower on Venus than on Earth, favoring retention of primordial cratered surfaces on portions of the crust that have not been destroyed or buried by tectonic and volcanic activity. Geochemical models of solar system origin and petrological considerations suggest that K is about as abundant in Venus as in Earth. The abundance of 40 Ar in the atmosphere of Venus lies somewhere between the Earth value and one-tenth of the Earth value. Because erosional liberation of 40 Ar on Venus will be relatively inefficient, this range for 40 Ar abundance at least permits an active tectonic history, and if the 40 Ar abundance is towards the high end of the range, it may well require an active tectonic history. Thus we are not constrained to a Mars-like model of Venus tectonics by craters and possible mantle dryness; an Earth-like model is equally probable

  11. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release

    Directory of Open Access Journals (Sweden)

    Florence P. Varodayan


    Full Text Available Many central synapses are highly sensitive to alcohol, and it is now accepted that short-term alterations in synaptic function may lead to longer term changes in circuit function. The regulation of postsynaptic receptors by alcohol has been well studied, but the mechanisms underlying the effects of alcohol on the presynaptic terminal are relatively unexplored. To identify a pathway by which alcohol regulates neurotransmitter release, we recently investigated the mechanism by which ethanol induces the Vamp2 gene, but not Vamp1, in mouse primary cortical cultures. These two genes encode isoforms of synaptobrevin, a vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE protein required for synaptic vesicle fusion. We found that alcohol activates the transcription factor heat shock factor 1 (HSF1 to induce Vamp2 gene expression, while Vamp1 mRNA levels remain unaffected. As the Vamp2 gene encodes a SNARE protein, we then investigated whether ethanol exposure and HSF1 transcriptional activity alter neurotransmitter release using electrophysiology. We found that alcohol increased the frequency of γ-aminobutyric acid (GABA-mediated miniature IPSCs via HSF1, but had no effect on mEPSCs. Overall, these data indicate that alcohol induces HSF1 transcriptional activity to trigger a specific coordinated adaptation in GABAergic presynaptic terminals. This mechanism could explain some of the changes in synaptic function that occur soon after alcohol exposure, and may underlie some of the more enduring effects of chronic alcohol intake on local circuit function.

  12. Expression and hypophysiotropic actions of corticotropin-releasing factor in Xenopus laevis. (United States)

    Boorse, Graham C; Denver, Robert J


    Members of the corticotropin-releasing factor (CRF) family of peptides play pivotal roles in the regulation of neuroendocrine, autonomic, and behavioral responses to physical and emotional stress. In amphibian tadpoles, CRF-like peptides stimulate both thyroid and interrenal (adrenal) hormone secretion, and can thereby modulate the rate of metamorphosis. To better understand the regulation of expression and actions of CRF in amphibians we developed a homologous radioimmunoassay (RIA) for Xenopus laevis CRF (xCRF). We validated this RIA and tissue extraction procedure for the measurement of brain CRF content in tadpoles and juveniles. We show that the CRF-binding protein, which is highly expressed in X. laevis brain, is largely removed by acid extraction and does not interfere in the RIA. We analyzed CRF peptide content in five microdissected brain regions in prometamorphic tadpoles and juveniles. CRF was detected throughout the brain, consistent with its role as both a hypophysiotropin and a neurotransmitter/neuromodulator. CRF content was highest in the region of the preoptic area (POa) and increased in all brain regions after metamorphosis. Exposure to 4h of handling/shaking stress resulted in increased CRF peptide content in the POa in juvenile frogs. Injections of xCRF into prometamorphic tadpoles increased whole body corticosterone and thyroxine content, thus supporting findings in other anuran species that this peptide functions as both a corticotropin- and a thyrotropin (TSH)-releasing factor. Furthermore, treatment of cultured tadpole pituitaries with xCRF (100nM for 24h) resulted in increased medium content, but decreased pituitary content of TSHbeta-immunoreactivity. Our results support the view that CRF functions as a stress neuropeptide in X. laevis as in other vertebrates. Furthermore, we provide evidence for a dual hypophysiotropic action of CRF on the thyroid and interrenal axes in X. laevis as has been shown previously in other amphibian species.

  13. Venus transits - A French view (United States)

    Débarbat, Suzanne


    After a careful study of Mars observations obtained by Tycho Brahé (1546-1601), Kepler (1571-1630) discovered the now-called Kepler's third law. In 1627 he published his famous Tabulae Rudolphinae, a homage to his protector Rudolph II (1552-1612), tables (Kepler 1609, 1627) from which he predicted Mercury and Venus transits over the Sun. In 1629 Kepler published his Admonitio ad Astronomos Advertisement to Astronomers (Kepler 1630), Avertissement aux Astronomes in French Au sujet de phénomènes rares et étonnants de l'an 1631: l'incursion de Vénus et de Mercure sur le Soleil. This was the beginning of the interest of French astronomers, among many others, in such transits, mostly for Venus, the subject of this paper in which dates are given in the Gregorian calendar.

  14. Signs of Life on Venus (United States)

    Ksanfomality, L.


    The search for "habitable zones" in extrasolar planetary systems is based on the premise of "normal" physical conditions in a habitable zone, i.e. pressure, temperature range, and atmospheric composition similar to those on the Earth. However, one should not exclude completely the possibility of the existence of life at relatively high temperatures, despite the fact that at the first glance it seems impossible. The planet Venus with its dense, hot (735 K), oxigenless CO2 - atmosphere and high 92 bar-pressure at the surface could be the natural laboratory for the studies of this type. Amid exoplanets, celestial bodies with the physical conditions similar to the Venusian can be met. The only existing data of actual close-in observations of Venus' surface are the results of a series of missions of the soviet VENERA landers which took place the 1970's and 80's in the atmosphere and on the surface of Venus. For 36 and 29 years since these missions, respectively, I repeatedly returned to the obtained images of the Venus' surface in order to reveal on them any unusual objects observed in the real conditions of Venus. The new analysis of the Venus' panoramas was based on the search of unusual elements in two ways. Since the efficiency of the VENERA landers maintained for a long time they produced a large number of primary television panoramas during the lander's work. Thus, one can try to detect: (a) any differences in successive images (appearance or disappearance of parts of the image or change of their shape), and understand what these changes are related to (e.g., wind), and whether they are related to hypothetical habitability of a planet. Another sign (b) of the wanted object is their morphological peculiarities which distinguishes them from the ordinary surface details. The results of VENERA-9 (1975) and VENERA -13 (1982) are of the main interest. A few relatively large objects ranging from a decimeter to half meter and with unusual morphology were observed in some

  15. Present status of the Japanese Venus climate orbiter (United States)

    Nakamura, M.; Imamura, T.; Abe, T.; Ishii, N.

    The code name of 24th science spacecraft of ISAS/JAXA is Planet-C. It is the first Venus Climate Orbiter (VCO) of Japan. The ministry of finance of Japan finally agreed to start phase B study of VCO from this April, 2004. We plan 1-2 years phase B study followed by 2 years of flight model integration. The spacecraft will be launched between 2009 and 2010. After arriving Venus, 2 years of operation is expected. VCO will complemet the ESA's Venus Express mission which have several spectrometers and will reveal the composition of the Venusian atmosphere. On the other hand, VCO is designed to reveal the details of the atmospheric motion on Venus and approach the dynamics of the Venusian climate. Cooperation between Japanese VCO and ESA's Venus Express, in the colaboration framework of U.S., Europian, and Japanese scienctist is very important. To elucidate the driving mechanism of the 4-days super-rotation is one of our main targets. We have 4 cameras to take snap shots of the planets in different wave lengths. They are the IR1 camera (1 micron-meter), the IR2 camera (2.4 micron-meter), the LIR camera (10-12 micron-meter), and the UVI camera (340nm). They are attached to the side panel of the 3-axis stabilized spacecraft, and are directed to Venus with the spacecraft's attitude control. Snap shots are expected to be taken every 2 hours. The spacecraft has an orbit of 300km x 13Rv (Venusian radii) with 172 degrees inclination. Orbital period is 30 hours. The angular position of the spacecraft on this orbit is synchronized for 20 hours at its apoapsis with the global atmospheric circulation at the altitude of 50km, thus the snap shots of every 2 hours will be the images of the same side of the atmosphere. In addition to these 4 cameras, we have a Lightning and Airglow camera (LAC) in visible range. This will be operated when the orbiter is close to the planet.

  16. The SPICAV-SOIR instrument probing the atmosphere of Venus: an overview (United States)

    Trompet, Loïc; Mahieux, Arnaud; Wilquet, Valérie; Robert, Séverine; Chamberlain, Sarah; Thomas, Ian; Carine Vandaele, Ann; Bertaux, Jean-Loup


    The Solar Occultation in the Infrared (SOIR) channel mounted on top of the SPICAV instrument of the ESA's Venus Express mission has observed the atmosphere of Venus during more than eight years. This IR spectrometer (2.2-4.3 μm) with a high spectral resolution (0.12 cm-1) combined an echelle grating with an acousto-optic tunable filter for order selection. SOIR performed more than 1500 solar occultation measurements leading to about two millions spectra. The Royal Belgian Institute for Space Aeronomy (BIRA-IASB) was in charge of SOIR's development and operations as well as its data pipeline. BIRA-IASB carried out several studies on the composition of Venus mesosphere and lower thermosphere: carbon dioxide, carbon monoxide, hydrogen halide (HF, HCl, DF, DCl), sulfur dioxide, water (H2O, HDO) as well as sulphuric acid aerosols in the upper haze of Venus. Density and temperature profiles of the upper atmosphere of Venus (60 km to 170 km) at the terminator have been retrieved from SOIR's spectra using different assumptions, wherein the hydrostatic equilibrium and the local thermodynamical equilibrium in the radiative transfer calculations. These results allow us to produce an Atmospheric model of Venus called Venus Atmosphere from SOIR measurements at the Terminator (VAST). Data obtained by SOIR will also contribute to update the Venus International Reference Atmosphere (VIRA). Recently, the treatment of the raw data to transmittance has been optimized, and a new dataset of spectra has been produced. All raw spectra (PSA level 2) as well as calibrated spectra (PSA level 3) have been delivered to ESA's Planetary Science Archive (PDSPSA). Consequently the re-analysis of all spectra has been undergone. We will briefly present the improvements implemented in the data pipeline. We will also show a compilation of results obtained by the instrument considering the complete mission duration.

  17. Investigating gravity waves evidences in the Venus upper atmosphere (United States)

    Migliorini, Alessandra; Altieri, Francesca; Shakun, Alexey; Zasova, Ludmila; Piccioni, Giuseppe; Bellucci, Giancarlo; Grassi, Davide


    We present a method to investigate gravity waves properties in the upper mesosphere of Venus, through the O2 nightglow observations acquired with the imaging spectrometer VIRTIS on board Venus Express. Gravity waves are important dynamical features that transport energy and momentum. They are related to the buoyancy force, which lifts air particles. Then, the vertical displacement of air particles produces density changes that cause gravity to act as restoring force. Gravity waves can manifest through fluctuations on temperature and density fields, and hence on airglow intensities. We use the O2 nightglow profiles showing double peaked structures to study the influence of gravity waves in shaping the O2 vertical profiles and infer the waves properties. In analogy to the Earth's and Mars cases, we use a well-known theory to model the O2 nightglow emissions affected by gravity waves propagation. Here we propose a statistical discussion of the gravity waves characteristics, namely vertical wavelength and wave amplitude, with respect to local time and latitude. The method is applied to about 30 profiles showing double peaked structures, and acquired with the VIRTIS/Venus Express spectrometer, during the mission period from 2006-07-05 to 2008-08-15.

  18. Gravity field of Venus - A preliminary analysis (United States)

    Phillips, R. J.; Sjogren, W. L.; Abbott, E. A.; Smith, J. C.; Wimberly, R. N.; Wagner, C. A.


    The gravitational field of Venus obtained by tracking the Pioneer Venus Orbiter is examined. For each spacecraft orbit, two hours of Doppler data centered around periapsis were used to estimate spacecraft position and velocity and the velocity residuals obtained were spline fit and differentiated to produce line of sight gravitational accelerations. Consistent variations in line of sight accelerations from orbit to orbit reveal the presence of gravitational anomalies. A simulation of isostatic compensation for an elevated region on the surface of Venus indicates that the mean depth of compensation is no greater than about 100 km. Gravitational spectra obtained from a Fourier analysis of line of sight accelerations from selected Venus orbits are compared to the earth's gravitational spectrum and spherical harmonic gravitational potential power spectra of the earth, the moon and Mars. The Venus power spectrum is found to be remarkably similar to that of the earth, however systematic variations in the harmonics suggest differences in dynamic processes or lithospheric behavior.

  19. Expression of transient receptor potential ankyrin 1 (TRPA1 and its role in insulin release from rat pancreatic beta cells.

    Directory of Open Access Journals (Sweden)

    De-Shou Cao

    Full Text Available Several transient receptor potential (TRP channels are expressed in pancreatic beta cells and have been proposed to be involved in insulin secretion. However, the endogenous ligands for these channels are far from clear. Here, we demonstrate the expression of the transient receptor potential ankyrin 1 (TRPA1 ion channel in the pancreatic beta cells and its role in insulin release. TRPA1 is an attractive candidate for inducing insulin release because it is calcium permeable and is activated by molecules that are produced during oxidative glycolysis.Immunohistochemistry, RT-PCR, and Western blot techniques were used to determine the expression of TRPA1 channel. Ca²⁺ fluorescence imaging and electrophysiology (voltage- and current-clamp techniques were used to study the channel properties. TRPA1-mediated insulin release was determined using ELISA.TRPA1 is abundantly expressed in a rat pancreatic beta cell line and freshly isolated rat pancreatic beta cells, but not in pancreatic alpha cells. Activation of TRPA1 by allyl isothiocyanate (AITC, hydrogen peroxide (H₂O₂, 4-hydroxynonenal (4-HNE, and cyclopentenone prostaglandins (PGJ₂ and a novel agonist methylglyoxal (MG induces membrane current, depolarization, and Ca²⁺ influx leading to generation of action potentials in a pancreatic beta cell line and primary cultured pancreatic beta cells. Activation of TRPA1 by agonists stimulates insulin release in pancreatic beta cells that can be inhibited by TRPA1 antagonists such as HC030031 or AP-18 and by RNA interference. TRPA1-mediated insulin release is also observed in conditions of voltage-gated Na⁺ and Ca²⁺ channel blockade as well as ATP sensitive potassium (K(ATP channel activation.We propose that endogenous and exogenous ligands of TRPA1 cause Ca²⁺ influx and induce basal insulin release and that TRPA1-mediated depolarization acts synergistically with K(ATP channel blockade to facilitate insulin release.

  20. The need for New In Situ Measurements to Understand the Climate, Geology and Evolution of Venus. (United States)

    Grinspoon, D. H.


    Many measurements needed to address outstanding questions about current processes and evolution of Venus can only be made from in situ platforms such as entry probes, balloons or landers. Among these are precise determination of the value and altitude dependence of the deuterium-to-hydrogen ratio, an important tracer of water history which, while clearly greatly elevated compared to the terrestrial ratio, is still unknown within a large range of uncertainty and appears, based on Venus Express results, to display an enigmatic altitude dependence. Rare gas abundances and isotopes provide clues to volatile sources and histories of outgassing and exospheric escape. Modern mass spectrometry at Venus would yield abundances of the eight stable xenon isotopes, bulk abundances of krypton, and isotopes of neon. Altitude profiles of sulfur-containing chemical species would illuminate global geochemical cycles, including cloud formation, outgassing rates and surface-atmosphere interactions. The altitude profile of wind speeds and radiation fluxes, interpreted in light of the Venus Express and Akatsuki data, would enrich understanding of the global circulation and climate dynamics of Venus. Descent and surface images of carefully chosen locations would lend ground truth to interpretations of the near-global Magellan data sets and provide context for global remote sensing data obtained by future orbiter missions. Landed instruments would provide refinement and calibration for chemical abundance measurements by historical missions as well as direct mineralogical measurements of Venusian surface and subsurface rocks. In concert with atmospheric measurements these would greatly constrain geologic history as well as the nature of surface-atmosphere interactions. Such a suite of measurements will deepen our understanding of the origin and evolution of Venus in the context of Solar System and extrasolar terrestrial planets, determine the level and style of current geological activity

  1. Gonadotropin-Releasing Hormone Regulates Expression of the DNA Damage Repair Gene, Fanconi anemia A, in Pituitary Gonadotroph Cells1


    Larder, Rachel; Chang, Lynda; Clinton, Michael; Brown, Pamela


    Gonadal function is critically dependant on regulated secretion of the gonadotropin hormones from anterior pituitary gonadotroph cells. Gonadotropin biosynthesis and release is triggered by the binding of hypothalamic GnRH to GnRH receptor expressed on the gonadotroph cell surface. The repertoire of regulatory molecules involved in this process are still being defined. We used the mouse LβT2 gonadotroph cell line, which expresses both gonadotropin hormones, as a model to investigate GnRH regu...

  2. Venus's winds and temperatures during the MESSENGER's flyby: towards a three-dimensional instantaneous state of the atmosphere (United States)

    Peralta, J.; Lee, Y. J.; Hueso, R.; Clancy, R. T.; Sandor, B. J.; Sánchez-Lavega, A.; Lellouch, E.; Rengel, M.; Machado, P.; Omino, M.; Piccialli, A.; Imamura, T.; Horinouchi, T.; Murakami, S.; Ogohara, K.; Luz, D.; Peach, D.


    The atmosphere of the Earth or Mars globally rotates with a speed similar to the rotation of the planet (approximately 24 h). The rotation of Venus is of about 243 days, much slower than the Earth, but when scientists measured the winds by tracking the clouds of Venus, they discovered that the atmosphere rotates 60 times faster! No one has explained yet what originates this "superrotation", and we do not know well what happens either above or below the clouds. The technique of "Doppler shift" has been used to measure winds above the clouds, but results are "chaotic" and different to interpret. Thanks to a worldwide collaboration in June 2007 between NASA (MESSENGER), ESA (Venus Express), and many observatories (VLT in Chile, JCMT in Hawaii, HHSMT in Arizona, or IRAM in Spain), the authors combined the different data to obtain, for the first time, the instantaneous 3-D structure of the winds on Venus at the clouds and also above, very important for new Venus models to start "forecasts" of the Venus weather with "data assimilation". We also discovered that the superrotation seems unexpectedly different on the night of Venus and that it varies its altitude depending on the day.

  3. Mars and Venus: unequal planets. (United States)

    Zimmerman, T S; Haddock, S A; McGeorge, C R


    Self-help books, a pervasive and influential aspect of society, can have a beneficial or detrimental effect on the therapeutic process. This article describes a thematic analysis and feminist critique of the best-selling self-help book, Men are from Mars, Women are from Venus. This analysis revealed that the author's materials are inconsistent with significant family therapy research findings and key principles of feminist theories. His descriptions of each gender and his recommendations for improving relationships serve to endorse and encourage power differentials between women and men.

  4. Distant interplanetary wake of Venus: plasma observations from pioneer Venus

    International Nuclear Information System (INIS)

    Mihalov, J.D.; Barnes, A.


    In June 1979 the Pioneer Venus orbiter made its first series of passes through the distant solar wind wake of Venus at distances of 8--12 R/sub V/ behind the planet. During this period the plasma analyzer aboard the spacecraft detected disturbed magnetosheath plasma that intermittently disappeared and reappeared, suggesting a tattered, filamentary cavity trailing behind the planet. The magnetosheath dropouts almost always occurred inside the region of 'magnetotail' observed by Russell et al. Sporadic bursts of energetic ions (E/q> or approx. =4kV) are detected inside and, occasionally, outside the magnetotail; all such bursts are consistent with identification of the ion as O + of planetary origin moving at the local magnetosheath flow speed. The morphology of the plasma dropouts and of the O + bursts is analyzed in detail. The cavity appears to contract at times of high solar wind dynamic pressure. The intensity of the O + component is highly variable, and appears not to be strongly correlated with solar wind dynamic pressure. The most intense bursts correspond to a flux 7 ions cm - 2 s - 1 . This maximum flux, if steady and filling a cylinder 1 R/sub V/ in radius would correspond to a mass loss rate of 25 ions s - 1 ; the intermittency and variability of the flux suggest that the true mean loss rate is very much lower. The kinetic temperature of the O + component is estimated as 10 5 --10 6 K in order of magnitude

  5. Composition and Chemistry of the Neutral Atmosphere of Venus (United States)

    Marcq, Emmanuel; Mills, Franklin P.; Parkinson, Christopher D.; Vandaele, Ann Carine


    This paper deals with the composition and chemical processes occurring in the neutral atmosphere of Venus. Since the last synthesis, observers as well as modellers have emphasised the spatial and temporal variability of minor species, going beyond a static and uniform picture that may have prevailed in the past. The outline of this paper acknowledges this situation and follows closely the different dimensions along which variability in composition can be observed: vertical, latitudinal, longitudinal, temporal. The strong differences between the atmosphere below and above the cloud layers also dictate the structure of this paper. Observational constraints, obtained from both Earth and Venus Express, as well as 1D, 2D and 3D models results obtained since 1997 are also extensively referred and commented by the authors. An non-exhaustive list of topics included follows: modelled and observed latitudinal and vertical profiles of CO and OCS below the clouds of Venus; vertical profiles of CO and SO2 above the clouds as observed by solar occultation and modelled; temporal and spatial variability of sulphur oxides above the clouds. As a conclusion, open questions and topics of interest for further studies are discussed.

  6. Expression and Regulation of Corticotropin-Releasing Factor Receptor Type 2 beta in Developing and Mature Mouse Skeletal Muscle

    NARCIS (Netherlands)

    Kuperman, Yael; Issler, Orna; Vaughan, Joan; Bilezikjian, Louise; Vale, Wylie; Chen, Alon

    Corticotropin-releasing factor receptor type 2 (CRFR2) is highly expressed in skeletal muscle (SM) tissue where it is suggested to inhibit interactions between insulin signaling pathway components affecting whole-body glucose homeostasis. However, little is known about factors regulating SM CRFR2

  7. Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus

    NARCIS (Netherlands)

    Cope, J.L.; Regev, L.; Chen, Y.; Korosi, A.; Rice, C.J.; Ji, S.; Rogge, G.A.; Wood, M.A.; Baram, T.Z.


    Corticotropin-releasing hormone (CRH) contributes crucially to the regulation of central and peripheral responses to stress. Because of the importance of a finely-tuned stress system, CRH expression is tightly regulated in an organ- and brain region-specific manner. Thus, in hypothalamus, CRH is

  8. Magnetic energy density and plasma energy density in the Venus wake (United States)

    Perez De Tejada, H. A.; Durand-Manterola, H. J.; Lundin, R.; Barabash, S.; Zhang, T.; Reyes-Ruiz, M.; Sauvaud, J.


    Magnetic energy density and plasma energy density in the Venus wake H. Pérez-de-Tejada1, H. Durand-Manterola1, R. Lundin2, S. Barabash2, T. L. Zhang3, A. Sauvaud4, M. Reyes-Ruiz5. 1 - Institute of Geophysics, UNAM, México, D. F. 2 - Swedish Institute of Space Physics, Umea, Sweden 3 - Space Research Institute, Graz, Austria 4 - CESR, Toulouse, France 5 - Institute of Astronomy, UNAM, Ensenada, México Measurements conducted in the Venus wake with the magnetometer and the Aspera-4 plasma instrument of the Venus Express spacecraft show that average values of the kinetic energy density of the plasma in that region are comparable to average local values of the magnetic energy density. Observations were carried out in several orbits of the Venus Express near the midnight plane and suggest that the total energy content in the Venus wake is distributed with nearly comparable values between the plasma and the magnetic field. Processes associated with the solar wind erosion of planetary ions from the polar magnetic regions of the ionosphere are involved in the comparable distribution of both energy components.

  9. Sulfur dioxide in the Venus atmosphere: I. Vertical distribution and variability (United States)

    Vandaele, A. C.; Korablev, O.; Belyaev, D.; Chamberlain, S.; Evdokimova, D.; Encrenaz, Th.; Esposito, L.; Jessup, K. L.; Lefèvre, F.; Limaye, S.; Mahieux, A.; Marcq, E.; Mills, F. P.; Montmessin, F.; Parkinson, C. D.; Robert, S.; Roman, T.; Sandor, B.; Stolzenbach, A.; Wilson, C.; Wilquet, V.


    Recent observations of sulfur containing species (SO2, SO, OCS, and H2SO4) in Venus' mesosphere have generated controversy and great interest in the scientific community. These observations revealed unexpected spatial patterns and spatial/temporal variability that have not been satisfactorily explained by models. Sulfur oxide chemistry on Venus is closely linked to the global-scale cloud and haze layers, which are composed primarily of concentrated sulfuric acid. Sulfur oxide observations provide therefore important insight into the on-going chemical evolution of Venus' atmosphere, atmospheric dynamics, and possible volcanism. This paper is the first of a series of two investigating the SO2 and SO variability in the Venus atmosphere. This first part of the study will focus on the vertical distribution of SO2, considering mostly observations performed by instruments and techniques providing accurate vertical information. This comprises instruments in space (SPICAV/SOIR suite on board Venus Express) and Earth-based instruments (JCMT). The most noticeable feature of the vertical profile of the SO2 abundance in the Venus atmosphere is the presence of an inversion layer located at about 70-75 km, with VMRs increasing above. The observations presented in this compilation indicate that at least one other significant sulfur reservoir (in addition to SO2 and SO) must be present throughout the 70-100 km altitude region to explain the inversion in the SO2 vertical profile. No photochemical model has an explanation for this behaviour. GCM modelling indicates that dynamics may play an important role in generating an inflection point at 75 km altitude but does not provide a definitive explanation of the source of the inflection at all local times or latitudes The current study has been carried out within the frame of the International Space Science Institute (ISSI) International Team entitled 'SO2 variability in the Venus atmosphere'.

  10. Expression and Role of Gonadotropin-Releasing Hormone 2 and Its Receptor in Mammals

    Directory of Open Access Journals (Sweden)

    Amy T. Desaulniers


    Full Text Available Gonadotropin-releasing hormone 1 (GnRH1 and its receptor (GnRHR1 drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2 and its receptor (GnRHR2 also exist in mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, signifying high selection pressure and a critical biological role. However, the GnRH2 gene is absent (e.g., rat or inactivated (e.g., cow and sheep in some species but retained in others (e.g., human, horse, and pig. Likewise, many species (e.g., human, chimpanzee, cow, and sheep retain the GnRHR2 gene but lack the appropriate coding sequence to produce a full-length protein due to gene coding errors; although production of GnRHR2 in humans remains controversial. Certain mammals lack the GnRHR2 gene (e.g., mouse or most exons entirely (e.g., rat. In contrast, old world monkeys, musk shrews, and pigs maintain the coding sequence required to produce a functional GnRHR2. Like GnRHR1, GnRHR2 is a 7-transmembrane, G protein-coupled receptor that interacts with Gαq/11 to mediate cell signaling. However, GnRHR2 retains a cytoplasmic tail and is only 40% homologous to GnRHR1. A role for GnRH2 and its receptor in mammals has been elusive, likely because common laboratory models lack both the ligand and receptor. Uniquely, both GnRH2 and GnRHR2 are ubiquitously expressed; transcript levels are abundant in peripheral tissues and scarcely found in regions of the brain associated with gonadotropin secretion, suggesting a divergent role from GnRH1/GnRHR1. Indeed, GnRH2 and its receptor are not physiological modulators of gonadotropin secretion in mammals. Instead, GnRH2 and GnRHR2 coordinate the interaction between nutritional status and sexual behavior in the female brain. Within peripheral tissues, GnRH2 and its receptor are novel regulators of reproductive organs. GnRH2 and GnRHR2 directly stimulate steroidogenesis within the porcine testis. In the female, GnRH2 and

  11. The Atmosphere and Climate of Venus (United States)

    Bullock, M. A.; Grinspoon, D. H.

    Venus lies just sunward of the inner edge of the Sun's habitable zone. Liquid water is not stable. Like Earth and Mars, Venus probably accreted at least an ocean's worth of water, although there are alternative scenarios. The loss of this water led to the massive, dry CO2 atmosphere, extensive H2SO4 clouds (at least some of the time), and an intense CO2 greenhouse effect. This chapter describes the current understanding of Venus' atmosphere, established from the data of dozens of spacecraft and atmospheric probe missions since 1962, and by telescopic observations since the nineteenth century. Theoretical work to model the temperature, chemistry, and circulation of Venus' atmosphere is largely based on analogous models developed in the Earth sciences. We discuss the data and modeling used to understand the temperature structure of the atmosphere, as well as its composition, cloud structure, and general circulation. We address what is known and theorized about the origin and early evolution of Venus' atmosphere. It is widely understood that Venus' dense CO2 atmosphere is the ultimate result of the loss of an ocean to space, but the timing of major transitions in Venus' climate is very poorly constrained by the available data. At present, the bright clouds allow only 20% of the sunlight to drive the energy balance and therefore determine conditions at Venus' surface. Like Earth and Mars, differential heating between the equator and poles drives the atmospheric circulation. Condensable species in the atmosphere create clouds and hazes that drive feedbacks that alter radiative forcing. Also in common with Earth and Mars, the loss of light, volatile elements to space produces long-term changes in composition and chemistry. As on Earth, geologic processes are most likely modifying the atmosphere and clouds by injecting gases from volcanos as well as directly through chemical reactions with the surface. The sensitivity of Venus' atmospheric energy balance is quantified in

  12. Effects of Sex Steroids on the Spinal Gastrin-Releasing Peptide System Controlling Male Sexual Function in Rats. (United States)

    Oti, Takumi; Takanami, Keiko; Ito, Saya; Ueda, Takashi; Matsuda, Ken Ichi; Kawata, Mitsuhiro; Soh, Jintetsu; Ukimura, Osamu; Sakamoto, Tatsuya; Sakamoto, Hirotaka


    The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord controls male sexual function in rats. In contrast, in female rats, GRP neurons could scarcely be detected around puberty when circulating ovarian steroid hormones such as estradiol and progesterone levels are increasing. However, little information is available on feminizing or demasculinizing effects of ovarian steroids on the central nervous system in female puberty and adulthood. In this study, to visualize the spinal GRP neurons in vivo, we generated a GRP-promoter-Venus transgenic (Tg) rat line and studied the effects of the sex steroid hormones on GRP expression in the rat lumbar cord by examining the Venus fluorescence. In these Tg rats, the sexually dimorphic spinal GRP neurons controlling male sexual function were clearly labeled with Venus fluorescence. As expected, Venus fluorescence in the male lumbar cord was markedly decreased after castration and restored by chronic androgen replacement. Furthermore, androgen-induced Venus expression in the spinal cord of adult Tg males was significantly attenuated by chronic treatment with progesterone but not with estradiol. A luciferase assay using a human GRP-promoter construct showed that androgens enhance the spinal GRP system, and more strikingly, that progesterone acts to inhibit the GRP system via an androgen receptor-mediated mechanism. These results demonstrate that circulating androgens may play an important role in the spinal GRP system controlling male sexual function not only in rats but also in humans and that progesterone could be an important feminizing factor in the spinal GRP system in females during pubertal development.

  13. Expression of the capacity to release [3H]norepinephrine by neural crest cultures

    International Nuclear Information System (INIS)

    Maxwell, G.D.; Sietz, P.D.


    Cultures of trunk neural crest cells from quail embryos were tested for their ability to release [ 3 H]norepinephrine [( 3 H]NE) in response to depolarization. After 7 days in vitro, exposure of the cultures to either the alkaloid veratridine or 40 mM K+ results in the evoked release of [ 3 H]NE. The release evoked by veratridine is blocked in the presence of tetrodotoxin. The release evoked by increased K+ is blocked by the calcium antagonist cobalt. Release in response to the nicotinic cholinergic agonist 1,1-dimethyl-4-phenylpiperazine was also observed. The amount of evoked release is highly correlated with the number of histochemically demonstrable catecholamine-containing cells in a given culture. Autoradiography reveals that the radioactivity taken up by these cultures is located in a subpopulation of cells whose morphology resembles that of the histochemically detectable catecholamine-containing cell population. Whereas capacity for the release of [ 3 H] NE is readily detectable after 7 days in vitro, it is detectable only with difficulty after 4 days in vitro. There is a greater than 6-fold increase in uptake capacity over the period of 4 to 7 days in vitro. These results demonstrate that neural crest cultures grown without their normal synaptic inputs or targets can exhibit the capacity for stimulus secretion coupling characteristic of synaptic neurotransmitter release

  14. Gene expression of thyrotropin- and corticotrophin-releasing hormones is regulated by environmental salinity in the euryhaline teleost Sparus aurata. (United States)

    Ruiz-Jarabo, Ignacio; Martos-Sitcha, J A; Barragán-Méndez, C; Martínez-Rodríguez, G; Mancera, J M; Arjona, F J


    In euryhaline teleosts, the hypothalamus-pituitary-thyroid and hypothalamus-pituitary-interrenal axes (HPT and HPI, respectively) are regulated in response to environmental stimuli such as salinity changes. However, the molecular players participating in this physiological process in the gilthead seabream (Sparus aurata), a species of high value for aquaculture, are still not identified and/or fully characterized in terms of gene expression regulation. In this sense, this study identifies and isolates the thyrotropin-releasing hormone (trh) mRNA sequence from S. aurata, encoding prepro-Trh, the putative factor initiating the HPT cascade. In addition, the regulation of trh expression and of key brain genes in the HPI axis, i.e., corticotrophin-releasing hormone (crh) and corticotrophin-releasing hormone-binding protein (crhbp), was studied when the osmoregulatory status of S. aurata was challenged by exposure to different salinities. The deduced amino acid structure of trh showed 65-81% identity with its teleostean orthologs. Analysis of the tissue distribution of gene expression showed that trh mRNA is, though ubiquitously expressed, mainly found in brain. Subsequently, regulation of gene expression of trh, crh, and crhbp was characterized in fish acclimated to 5-, 15-, 40-, and 55-ppt salinities. In this regard, the brain gene expression pattern of trh mRNA was similar to that found for the crh gene, showing an upregulation of gene expression in seabream acclimated to the highest salinity tested. Conversely, crhbp did not change in any of the groups tested. Our results suggest that Trh and Crh play an important role in the acclimation of S. aurata to hypersaline environments.

  15. Nature of the Venus thermosphere derived from satellite drag measurements (solicited paper) (United States)

    Keating, G.; Theriot, M.; Bougher, S.


    atmosphere rises on the dayside producing adiabatic cooling and drops on the nightside producing some adiabatic heating. (See figure 1). The thermosphere was discovered from drag measurements to respond to the near 27-day period of the rotating Sun, for which regions of maximum solar activity reappear every 27 days. The increased euv emission from active regions increased temperatures and thermospheric density, (See Figure 2). Fig. 2 Exospheric Temperatures Compared to 10.7cm Solar Index Second diurnal survey (12/5/79 - 3/6/80) Pioneer Venus Orbiter measurements (OAD) 11 day running means [2] Estimates were also made of the response to the 11- year Solar Cycle by combining the Pioneer Venus and Magellan data. Dayside exospheric temperatures changed about 80K over the solar cycle, [8]. Earlier estimates of temperature change gave 70K based on Lyman alpha measurements. The responses to solar variability were much weaker than on Earth due apparently to the much stronger O/CO2 cooling on Venus which tended to act as a thermostat on thermospheric temperatures. Another discovery from drag measurements was the 4 to 5 day oscillation of the Venus thermosphere [3], (See figure 3). These oscillations are interpreted as resulting from the 4-day super-rotation of the atmosphere near the cloud tops. Other indications of the super-rotation of the thermosphere come from displacement of the helium bulge and atomic hydrogen bulge from midnight to near 4AM. Fig. 3 Four to Five Day Oscillations in Thermospheric Densities Magellan 1992. During 2008, the Venus Express periapsis will be dropped from 250km down to approximately 180km to allow drag measurements to be made in the North Polar Region, [9]. Drag measurements above 200km have already been obtained from both Pioneer Venus and Magellan so measurements near 180km should be accurate. In 2009, the periapsis may be decreased to a lower altitude allowing accelerometer measurements to be obtained of drag as a function of altitude, to determine

  16. Global Geological Map of Venus (United States)

    Ivanov, M. A.


    Introduction: The Magellan SAR images provide sufficient data to compile a geological map of nearly the entire surface of Venus. Such a global and selfconsistent map serves as the base to address the key questions of the geologic history of Venus. 1) What is the spectrum of units and structures that makes up the surface of Venus [1-3]? 2) What volcanic/tectonic processes do they characterize [4-7]? 3) Did these processes operated locally, regionally, or globally [8- 11]? 4) What are the relationships of relative time among the units [8]? 5) At which length-scale these relationships appear to be consistent [8-10]? 6) What is the absolute timing of formation of the units [12-14]? 7) What are the histories of volcanism, tectonics and the long-wavelength topography on Venus? 7) What model(s) of heat loss and lithospheric evolution [15-21] do these histories correspond to? The ongoing USGS program of Venus mapping has already resulted in a series of published maps at the scale 1:5M [e.g. 22-30]. These maps have a patch-like distribution, however, and are compiled by authors with different mapping philosophy. This situation not always results in perfect agreement between the neighboring areas and, thus, does not permit testing geological hypotheses that could be addressed with a self-consistent map. Here the results of global geological mapping of Venus at the scale 1:10M is presented. The map represents a contiguous area extending from 82.5oN to 82.5oS and comprises ~99% of the planet. Mapping procedure: The map was compiled on C2- MIDR sheets, the resolution of which permits identifying the basic characteristics of previously defined units. The higher resolution images were used during the mapping to clarify geologic relationships. When the map was completed, its quality was checked using published USGS maps [e.g., 22-30] and the catalogue of impact craters [31]. The results suggest that the mapping on the C2-base provided a highquality map product. Units and

  17. High Temperature, Wireless Seismometer Sensor for Venus (United States)

    Ponchak, George E.; Scardelletti, Maximilian C.; Taylor, Brandt; Beard, Steve; Meredith, Roger D.; Beheim, Glenn M.; Hunter Gary W.; Kiefer, Walter S.


    Space agency mission plans state the need to measure the seismic activity on Venus. Because of the high temperature on Venus (462? C average surface temperature) and the difficulty in placing and wiring multiple sensors using robots, a high temperature, wireless sensor using a wide bandgap semiconductor is an attractive option. This paper presents the description and proof of concept measurements of a high temperature, wireless seismometer sensor for Venus. A variation in inductance of a coil caused by the movement of an aluminum probe held in the coil and attached to a balanced leaf-spring seismometer causes a variation of 700 Hz in the transmitted signal from the oscillator/sensor system at 426? C. This result indicates that the concept may be used on Venus.

  18. A statistical study of ionopause perturbation and associated boundary wave formation at Venus. (United States)

    Chong, G. S.; Pope, S. A.; Walker, S. N.; Zhang, T.; Balikhin, M. A.


    In contrast to Earth, Venus does not possess an intrinsic magnetic field. Hence the interaction between solar wind and Venus is significantly different when compared to Earth, even though these two planets were once considered similar. Within the induced magnetosphere and ionosphere of Venus, previous studies have shown the existence of ionospheric boundary waves. These structures may play an important role in the atmospheric evolution of Venus. By using Venus Express data, the crossings of the ionopause boundary are determined based on the observations of photoelectrons during 2011. Pulses of dropouts in the electron energy spectrometer were observed in 92 events, which suggests potential perturbations of the boundary. Minimum variance analysis of the 1Hz magnetic field data for the perturbations is conducted and used to confirm the occurrence of the boundary waves. Statistical analysis shows that they were propagating mainly in the ±VSO-Y direction in the polar north terminator region. The generation mechanisms of boundary waves and their evolution into the potential nonlinear regime are discussed and analysed.

  19. Venus and the Archean Earth: Thermal considerations

    International Nuclear Information System (INIS)

    Sleep, N.H.


    The Archean Era of the Earth is not a direct analog of the present tectonics of Venus. In this regard, it is useful to review the state of the Archean Earth. Most significantly, the temperature of the adiabatic interior of the Earth was 200 to 300 C hotter than the current temperature. Preservation biases limit what can be learned from the Archean record. Archean oceanic crust, most of the planetary surface at any one time, has been nearly all subducted. More speculatively, the core of the Earth has probably cooled more slowly than the mantle. Thus the temperature contrast above the core-mantle boundary and the vigor of mantle plumes has increased with time on the Earth. The most obvious difference between Venus and the present Earth is the high surface temperature and hence a low effective viscosity of the lithosphere. In addition, the temperature contrast between the adiabatic interior and the surface, which drives convection, is less on Venus than on the Earth. It appears that the hot lithosphere enhanced tectonics on the early Venus significantly enough that its interior cooled faster than the Earth's. The best evidence for a cool interior of Venus comes from long wavelength gravity anomalies. The low interior temperatures retard seafloor spreading on Venus. The high surface temperatures on Venus enhance crustal deformation. That is, the lower crust may become ductile enough to permit significant flow between the upper crust and the mantle. There is thus some analogy to modern and ancient areas of high heat flow on the Earth. Archean crustal blocks typically remained stable for long intervals and thus overall are not good analogies to the deformation style on Venus

  20. First operations of the SOIR occultation infrared spectrometer in Venus orbit. (United States)

    Nevejans, D.; Neefs, E.; Vandaele, A. C.; Muller, C.; Fussen, D.; Berkenbosch, S.; Clairquin, R.; Korablev, O.; Federova, A.; Bertaux, J. L.

    Since May 2006, the Venus-Express spacecraft is in its nominal orbit around VENUS and the SPICAV optical package has begun to acquire spectra. The SOIR extension to SPICAV is an echelle spectrometer associated to an AOTF (Acousto-Optical Tunable Filter) for the order selection, which performs solar occultation measurements in the IR region (2.2-4.3 µm) at a resolution of 0.1 cm-1 . The detailed optical study and design as well as the manufacturing were performed at the BIRA/IASB in collaboration with its industrial partners OIP and PEDEO. It was funded by the Belgian Federal Science Policy Office under the ESA PRODEX programme. The wavelength range allows a detailed chemical inventory of the Venus atmosphere above the cloud layer with an emphasis on vertical distribution of gases. The first results look promising and will be qualitatively presented.

  1. Towards Understanding the Climate of Venus Applications of Terrestrial Models to Our Sister Planet

    CERN Document Server

    Bonnet, Roger-Maurice; Grinspoon, David; Koumoutsaris, Symeon; Lebonnois, Sebastien; Titov, Dmitri


    ESA’s Venus Express Mission has monitored Venus since April 2006, and scientists worldwide have used mathematical models to investigate its atmosphere and model its circulation. This book summarizes recent work to explore and understand the climate of the planet through a research program under the auspices of the International Space Science Institute (ISSI) in Bern, Switzerland. Some of the unique elements that are discussed are the anomalies with Venus’ surface temperature (the huge greenhouse effect causes the surface to rise to 460°C, without which would plummet as low as -40°C), its unusual lack of solar radiation (despite being closer to the Sun, Venus receives less solar radiation than Earth due to its dense cloud cover reflecting 76% back) and the juxtaposition of its atmosphere and planetary rotation (wind speeds can climb up to 200 m/s, much faster than Venus’ sidereal day of 243 Earth-days).

  2. Geology of Maxwell Montes, Venus (United States)

    Head, J. W.; Campbell, D. B.; Peterfreund, A. R.; Zisk, S. A.


    Maxwell Montes represent the most distinctive topography on the surface of Venus, rising some 11 km above mean planetary radius. The multiple data sets of the Pioneer missing and Earth based radar observations to characterize Maxwell Montes are analyzed. Maxwell Montes is a porkchop shaped feature located at the eastern end of Lakshmi Planum. The main massif trends about North 20 deg West for approximately 1000 km and the narrow handle extends several hundred km West South-West WSW from the north end of the main massif, descending down toward Lakshmi Planum. The main massif is rectilinear and approximately 500 km wide. The southern and northern edges of Maxwell Montes coincide with major topographic boundaries defining the edge of Ishtar Terra.

  3. A dynamic model of Venus's gravity field (United States)

    Kiefer, W. S.; Richards, M. A.; Hager, B. H.; Bills, B. G.


    Unlike Earth, long wavelength gravity anomalies and topography correlate well on Venus. Venus's admittance curve from spherical harmonic degree 2 to 18 is inconsistent with either Airy or Pratt isostasy, but is consistent with dynamic support from mantle convection. A model using whole mantle flow and a high viscosity near surface layer overlying a constant viscosity mantle reproduces this admittance curve. On Earth, the effective viscosity deduced from geoid modeling increases by a factor of 300 from the asthenosphere to the lower mantle. These viscosity estimates may be biased by the neglect of lateral variations in mantle viscosity associated with hot plumes and cold subducted slabs. The different effective viscosity profiles for Earth and Venus may reflect their convective styles, with tectonism and mantle heat transport dominated by hot plumes on Venus and by subducted slabs on Earth. Convection at degree 2 appears much stronger on Earth than on Venus. A degree 2 convective structure may be unstable on Venus, but may have been stabilized on Earth by the insulating effects of the Pangean supercontinental assemblage.

  4. Space weather at planet Venus during the forthcoming BepiColombo flybys (United States)

    McKenna-Lawlor, S.; Jackson, B.; Odstrcil, D.


    The BepiColombo (BC) Mission which will be launched in 2018, will include during its Cruise Phase two flybys of Venus and five Mercury flybys. It will then enter a one Earth year orbit about Mercury (with a possible one-year extension) during which two spacecraft, one provided by ESA (MPO) and one provided by JAXA (MMO), will perform both autonomous and coordinated observations of the Hermean environment at various separations. The measurements will take place during the minimum of solar cycle 24 and the rise of solar cycle 25. At the start of the minimum of solar cycle 23, four major flares, each associated with the production of MeV particle radiation and CME activity occurred. Predictions of the HAFv.2 model of the arrival of particle radiation and a travelling shock at Venus on 6 December 2006 were verified by in-situ measurements made aboard Venus Express (VEX) by the ASPERA 4 instrument. Interplanetary scintillation observations, as well as the ENLIL 3-D MHD model when employed separately or in combination, enable the making of predictions of the solar wind density and speed at various locations in the inner heliosphere. Both methods, which outdate HAFv.2, are utilized in the present paper to predict (retrospectively) the arrival of the flare related, interplanetary propagating shock recorded at Venus on 6 December 2006 aboard VEX with a view to putting in place the facility to make very reliable space weather predictions for BC during both its Cruise Phase and when in the Hermean environment itself. The successful matching of the December 2006 predictions with in-situ signatures recorded aboard Venus Express provide confidence that the predictive methodology to be adopted will be appropriate to provide space weather predictions for BepiColombo during its Venus flybys and throughout the mission.

  5. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. (United States)

    Elgueta, Claudio; Vielma, Alex H; Palacios, Adrian G; Schmachtenberg, Oliver


    Acetylcholine (ACh) is a major retinal neurotransmitter that modulates visual processing through a large repertoire of cholinergic receptors expressed on different retinal cell types. ACh is released from starburst amacrine cells (SACs) under scotopic conditions, but its effects on cells of the rod pathway have not been investigated. Using whole-cell patch clamp recordings in slices of rat retina, we found that ACh application triggers GABA release onto rod bipolar (RB) cells. GABA was released from A17 amacrine cells and activated postsynaptic GABAA and GABAC receptors in RB cells. The sensitivity of ACh-induced currents to nicotinic ACh receptor (nAChR) antagonists (TMPH ~ mecamylamine > erysodine > DhβE > MLA) together with the differential potency of specific agonists to mimic ACh responses (cytisine > RJR2403 ~ choline), suggest that A17 cells express heteromeric nAChRs containing the β4 subunit. Activation of nAChRs induced GABA release after Ca(2+) accumulation in A17 cell dendrites and varicosities mediated by L-type voltage-gated calcium channels (VGCCs) and intracellular Ca(2+) stores. Inhibition of acetylcholinesterase depolarized A17 cells and increased spontaneous inhibitory postsynaptic currents in RB cells, indicating that endogenous ACh enhances GABAergic inhibition of RB cells. Moreover, injection of neostigmine or cytisine reduced the b-wave of the scotopic flash electroretinogram (ERG), suggesting that cholinergic modulation of GABA release controls RB cell activity in vivo. These results describe a novel regulatory mechanism of RB cell inhibition and complement our understanding of the neuromodulatory control of retinal signal processing.


    National Aeronautics and Space Administration — Galileo Orbiter 60 second sampled trajectory data from the Venus flyby in Venus Solar Orbital (VSO) coordinates. These data cover the interval 1990-02-09 00:00 to...

  7. VICI (Venus In Situ Composition Investigations): The Next Step in Understanding Venus Climate Evolution (United States)

    Glaze, L. S.; Garvin, J. B.


    Venus provides a natural laboratory to explore an example of terrestrial planet evolution that may be cosmically ubiquitous. By better understanding the composition of the Venus atmosphere and surface, we can better constrain the efficiency of the Venusian greenhouse. VICI is a proposed NASA New Frontiers mission that delivers two landers to Venus on two separate Venus fly-bys. Following six orbital remote sensing missions to Venus (since 1978), VICI would be the first mission to land on the Venus surface since 1985, and the first U.S. mission to enter the Venus atmosphere in 49 years. The four major VICI science objectives are: Atmospheric origin and evolution: Understand the origin of the Venus atmosphere, how it has evolved, including how recently Venus lost its oceans, and how and why it is different from the atmospheres of Earth and Mars, through in situ measurements of key noble gases, nitrogen, and hydrogen. Atmospheric composition and structure: Reveal the unknown chemical processes and structure in Venus' deepest atmosphere that dominate the current climate through two comprehensive, in situ vertical profiles. Surface properties and geologic evolution: For the first time ever, explore the tessera from the surface, specifically to test hypotheses of ancient content-building cycles, erosion, and links to past climates using multi-point mineralogy, elemental chemistry, imaging and topography. Surface-atmosphere interactions: Characterize Venus' surface weathering environment and provide insight into the sulfur cycle at the surface-atmosphere interface by integrating rich atmospheric composition and structure datasets with imaging, surface mineralogy, and elemental rock composition. VICI is designed to study Venus' climate history through detailed atmospheric composition measurements not possible on earlier missions. In addition, VICI images the tessera surface during descent enabling detailed topography to be generated. Finally, VICI makes multiple elemental

  8. Expression and role of gonadotropin-releasing hormone 2 and its receptor in mammals (United States)

    Gonadotropin-releasing hormone (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in some mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, s...

  9. Large Volcanic Rises on Venus (United States)

    Smrekar, Suzanne E.; Kiefer, Walter S.; Stofan, Ellen R.


    Large volcanic rises on Venus have been interpreted as hotspots, or the surface manifestation of mantle upwelling, on the basis of their broad topographic rises, abundant volcanism, and large positive gravity anomalies. Hotspots offer an important opportunity to study the behavior of the lithosphere in response to mantle forces. In addition to the four previously known hotspots, Atla, Bell, Beta, and western Eistla Regiones, five new probable hotspots, Dione, central Eistla, eastern Eistla, Imdr, and Themis, have been identified in the Magellan radar, gravity and topography data. These nine regions exhibit a wider range of volcano-tectonic characteristics than previously recognized for venusian hotspots, and have been classified as rift-dominated (Atla, Beta), coronae-dominated (central and eastern Eistla, Themis), or volcano-dominated (Bell, Dione, western Eistla, Imdr). The apparent depths of compensation for these regions ranges from 65 to 260 km. New estimates of the elastic thickness, using the 90 deg and order spherical harmonic field, are 15-40 km at Bell Regio, and 25 km at western Eistla Regio. Phillips et al. find a value of 30 km at Atla Regio. Numerous models of lithospheric and mantle behavior have been proposed to interpret the gravity and topography signature of the hotspots, with most studies focusing on Atla or Beta Regiones. Convective models with Earth-like parameters result in estimates of the thickness of the thermal lithosphere of approximately 100 km. Models of stagnant lid convection or thermal thinning infer the thickness of the thermal lithosphere to be 300 km or more. Without additional constraints, any of the model fits are equally valid. The thinner thermal lithosphere estimates are most consistent with the volcanic and tectonic characteristics of the hotspots. Estimates of the thermal gradient based on estimates of the elastic thickness also support a relatively thin lithosphere (Phillips et al.). The advantage of larger estimates of

  10. Geologic map of the Artemis Chasma quadrangle (V-48), Venus (United States)

    Bannister, Roger A.; Hansen, Vicki L.


    . So although it seems clear what Artemis is not, there is little consensus about what Artemis is, much less how Artemis formed. Debate during the past decade has resulted in the proposal of at least four hypotheses for Artemis' formation. The first (herein referred to as H1) is that Artemis Chasma represents a zone of northwest-directed convergence and subduction. The second hypothesis (herein referred to as H2) is that Artemis consists of a composite structure with a part of its interior region marking the exposure of deformed ductile deep-crustal rocks analogous to a terrestrial metamorphic core complex. The third (herein referred to as H3) is that Artemis reflects the surface expression of an ancient (>3.5 Ga) huge bolide impact event on cold strong lithosphere. The fourth hypothesis (herein referred to as H4) is that Artemis marks the surface expression of a deep mantle plume. Each of these hypotheses holds different implications for Venus geodynamics and evolution processes, and for terrestrial planet processes in general. Viability of H1 would provide support that terrestrial-like plate-tectonic processes once occurred on Earth's sister planet. The feasibility of H2 would require high values of crustal extension and therefore imply that significant horizontal displacements occurred on Venus-displacement that may or may not be related to terrestrial-like plate-tectonic processes. The possibility of H3 would suggest that Venus' surface is extremely old, and that Venus has experienced very little dynamic activity for the last 3.5 billion years or more; this would further imply that Venus is essentially tectonically dead, and has been for most of its history. This view contrasts strongly with studies that highlight a rich history of Venus including activity at least as young as 750 million years ago, and quite likely up to the present. If H4 has credibility, then Artemis could provide clues to cooling mechanisms of Earth's sister planet. Each of these hypotheses

  11. Developmental Regulation of Gonadotropin-releasing Hormone Gene Expression by the MSX and DLX Homeodomain Protein Families* (United States)

    Givens, Marjory L.; Rave-Harel, Naama; Goonewardena, Vinodha D.; Kurotani, Reiko; Berdy, Sara E.; Swan, Christo H.; Rubenstein, John L. R.; Robert, Benoit; Mellon, Pamela L.


    Gonadotropin-releasing hormone (GnRH) is the central regulator of the hypothalamic-pituitary-gonadal axis, controlling sexual maturation and fertility in diverse species from fish to humans. GnRH gene expression is limited to a discrete population of neurons that migrate through the nasal region into the hypothalamus during embryonic development. The GnRH regulatory region contains four conserved homeodomain binding sites (ATTA) that are essential for basal promoter activity and cell-specific expression of the GnRH gene. MSX and DLX are members of the Antennapedia class of non-Hox homeodomain transcription factors that regulate gene expression and influence development of the craniofacial structures and anterior forebrain. Here, we report that expression patterns of the Msx and Dlx families of homeodomain transcription factors largely coincide with the migratory route of GnRH neurons and co-express with GnRH in neurons during embryonic development. In addition, MSX and DLX family members bind directly to the ATTA consensus sequences and regulate transcriptional activity of the GnRH promoter. Finally, mice lacking MSX1 or DLX1 and 2 show altered numbers of GnRH-expressing cells in regions where these factors likely function. These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development. PMID:15743757

  12. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. (United States)

    Givens, Marjory L; Rave-Harel, Naama; Goonewardena, Vinodha D; Kurotani, Reiko; Berdy, Sara E; Swan, Christo H; Rubenstein, John L R; Robert, Benoit; Mellon, Pamela L


    Gonadotropin-releasing hormone (GnRH) is the central regulator of the hypothalamic-pituitary-gonadal axis, controlling sexual maturation and fertility in diverse species from fish to humans. GnRH gene expression is limited to a discrete population of neurons that migrate through the nasal region into the hypothalamus during embryonic development. The GnRH regulatory region contains four conserved homeodomain binding sites (ATTA) that are essential for basal promoter activity and cell-specific expression of the GnRH gene. MSX and DLX are members of the Antennapedia class of non-Hox homeodomain transcription factors that regulate gene expression and influence development of the craniofacial structures and anterior forebrain. Here, we report that expression patterns of the Msx and Dlx families of homeodomain transcription factors largely coincide with the migratory route of GnRH neurons and co-express with GnRH in neurons during embryonic development. In addition, MSX and DLX family members bind directly to the ATTA consensus sequences and regulate transcriptional activity of the GnRH promoter. Finally, mice lacking MSX1 or DLX1 and 2 show altered numbers of GnRH-expressing cells in regions where these factors likely function. These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development.

  13. Schizothorax prenanti corticotropin-releasing hormone (CRH): molecular cloning, tissue expression, and the function of feeding regulation. (United States)

    Wang, Tao; Zhou, Chaowei; Yuan, Dengyue; Lin, Fangjun; Chen, Hu; Wu, Hongwei; Wei, Rongbin; Xin, Zhiming; Liu, Ju; Gao, Yundi; Li, Zhiqiong


    Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. For a better understanding of the structure and function of the CRH gene and to study its effect on feeding regulation in cyprinid fish, the cDNA of the CRH gene from the brain of Schizothorax prenanti was cloned and sequenced. The full-length CRH cDNA consisted of 1,046 bp with an open reading frame of 489 bp encoding a protein of 162 amino acids. Real-time quantitative PCR analyses revealed that CRH was widely expressed in central and peripheral tissues. In particular, high expression level of CRH was detected in brain. Furthermore, CRH mRNA expression was examined in different brain regions, especially high in hypothalamus. In addition, there was no significant change in CRH mRNA expression in fed group compared with the fasted group in the S. prenanti hypothalamus during short-term fasting. However, CRH gene expression presented significant decrease in the hypothalamus in fasted group compared with the fed group (P < 0.05) on day 7; thereafter, re-feeding could lead to a significant increase in CRH mRNA expression in fasted group on day 9. The results suggest that the CRH may play a critical role in feeding regulation in S. prenanti.

  14. Gonadotropin-Releasing Hormone Regulates Expression of the DNA Damage Repair Gene, Fanconi anemia A, in Pituitary Gonadotroph Cells1 (United States)

    Larder, Rachel; Chang, Lynda; Clinton, Michael; Brown, Pamela


    Gonadal function is critically dependant on regulated secretion of the gonadotropin hormones from anterior pituitary gonadotroph cells. Gonadotropin biosynthesis and release is triggered by the binding of hypothalamic GnRH to GnRH receptor expressed on the gonadotroph cell surface. The repertoire of regulatory molecules involved in this process are still being defined. We used the mouse LβT2 gonadotroph cell line, which expresses both gonadotropin hormones, as a model to investigate GnRH regulation of gene expression and differential display reverse transcription-polymerase chain reaction (RT-PCR) to identify and isolate hormonally induced changes. This approach identified Fanconi anemia a (Fanca), a gene implicated in DNA damage repair, as a differentially expressed transcript. Mutations in Fanca account for the majority of cases of Fanconi anemia (FA), a recessively inherited disease identified by congenital defects, bone marrow failure, infertility, and cancer susceptibility. We confirmed expression and hormonal regulation of Fanca mRNA by quantitative RT-PCR, which showed that GnRH induced a rapid, transient increase in Fanca mRNA. Fanca protein was also acutely upregulated after GnRH treatment of LβT2 cells. In addition, Fanca gene expression was confined to mature pituitary gonadotrophs and adult mouse pituitary and was not expressed in the immature αT3-1 gonadotroph cell line. Thus, this study extends the expression profile of Fanca into a highly specialized endocrine cell and demonstrates hormonal regulation of expression of the Fanca locus. We suggest that this regulatory mechanism may have a crucial role in the GnRH-response mechanism of mature gonadotrophs and perhaps the etiology of FA. PMID:15128600

  15. Gonadotropin-releasing hormone regulates expression of the DNA damage repair gene, Fanconi anemia A, in pituitary gonadotroph cells. (United States)

    Larder, Rachel; Chang, Lynda; Clinton, Michael; Brown, Pamela


    Gonadal function is critically dependant on regulated secretion of the gonadotropin hormones from anterior pituitary gonadotroph cells. Gonadotropin biosynthesis and release is triggered by the binding of hypothalamic GnRH to GnRH receptor expressed on the gonadotroph cell surface. The repertoire of regulatory molecules involved in this process are still being defined. We used the mouse L beta T2 gonadotroph cell line, which expresses both gonadotropin hormones, as a model to investigate GnRH regulation of gene expression and differential display reverse transcription-polymerase chain reaction (RT-PCR) to identify and isolate hormonally induced changes. This approach identified Fanconi anemia a (Fanca), a gene implicated in DNA damage repair, as a differentially expressed transcript. Mutations in Fanca account for the majority of cases of Fanconi anemia (FA), a recessively inherited disease identified by congenital defects, bone marrow failure, infertility, and cancer susceptibility. We confirmed expression and hormonal regulation of Fanca mRNA by quantitative RT-PCR, which showed that GnRH induced a rapid, transient increase in Fanca mRNA. Fanca protein was also acutely upregulated after GnRH treatment of L beta T2 cells. In addition, Fanca gene expression was confined to mature pituitary gonadotrophs and adult mouse pituitary and was not expressed in the immature alpha T3-1 gonadotroph cell line. Thus, this study extends the expression profile of Fanca into a highly specialized endocrine cell and demonstrates hormonal regulation of expression of the Fanca locus. We suggest that this regulatory mechanism may have a crucial role in the GnRH-response mechanism of mature gonadotrophs and perhaps the etiology of FA.

  16. Peri-pubertal gonadotropin-releasing hormone agonist treatment affects sex biased gene expression of amygdala in sheep. (United States)

    Nuruddin, Syed; Krogenæs, Anette; Brynildsrud, Ola Brønstad; Verhaegen, Steven; Evans, Neil P; Robinson, Jane E; Haraldsen, Ira Ronit Hebold; Ropstad, Erik


    The nature of hormonal involvement in pubertal brain development has attracted wide interest. Structural changes within the brain that occur during pubertal development appear mainly in regions closely linked with emotion, motivation and cognitive functions. Using a sheep model, we have previously shown that peri-pubertal pharmacological blockade of gonadotropin releasing hormone (GnRH) receptors, results in exaggerated sex-differences in cognitive executive function and emotional control, as well as sex and hemisphere specific patterns of expression of hippocampal genes associated with synaptic plasticity and endocrine signaling. In this study, we explored effects of this treatment regime on the gene expression profile of the ovine amygdala. The study was conducted with 30 same-sex twin lambs (14 female and 16 male), half of which were treated with the GnRH agonist (GnRHa) goserelin acetate every 4th week, beginning before puberty, until approximately 50 weeks of age. Gene expression profiles of the left and right amygdala were measured using 8×15 K Agilent ovine microarrays. Differential expression of selected genes was confirmed by qRT-PCR (Quantitative real time PCR). Networking analyses and Gene Ontology (GO) Term analyses were performed with Ingenuity Pathway Analysis (IPA), version 7.5 and DAVID (Database for Annotation, Visualization and integrated Discovery) version 6.7 software packages, respectively. GnRHa treatment was associated with significant sex- and hemisphere-specific differential patterns of gene expression. GnRHa treatment was associated with differential expression of 432 (|logFC|>0.3, adj. p value expressed as a result of GnRHa treatment in the male animals. The results indicated that GnRH may, directly and/or indirectly, be involved in the regulation of sex- and hemisphere-specific differential expression of genes in the amygdala. This finding should be considered when long-term peri-pubertal GnRHa treatment is used in children. Copyright

  17. Innovative measurement within the atmosphere of Venus. (United States)

    Ekonomov, Alexey; Linkin, Vyacheslav; Manukin, Anatoly; Makarov, Vladislav; Lipatov, Alexander

    The results of Vega project experiments with two balloons flew in the cloud layer of the atmosphere of Venus are analyzed as to the superrotation nature and local dynamic and thermodynamic characteristics of the atmosphere. These balloons in conjunction with measurements of temperature profiles defined by the Fourier spectrometer measurements from the spacecraft Venera 15 allow us to offer a mechanism accelerating the atmosphere to high zonal velocities and supporting these speeds, the atmosphere superrotation in general. Spectral measurements with balloons confirm the possibility of imaging the planet's surface from a height of not more than 55 km. Promising experiments with balloons in the atmosphere of Venus are considered. In particular, we discuss the possibility of measuring the geopotential height, as Venus no seas and oceans to vertical positioning of the temperature profiles. As an innovative research facilities within the atmosphere overpressure balloon with a lifetime longer than 14 Earth days and vertical profile microprobes are considered.

  18. High-resolution gravity model of Venus (United States)

    Reasenberg, R. D.; Goldberg, Z. M.


    The anomalous gravity field of Venus shows high correlation with surface features revealed by radar. We extract gravity models from the Doppler tracking data from the Pioneer Venus Orbiter by means of a two-step process. In the first step, we solve the nonlinear spacecraft state estimation problem using a Kalman filter-smoother. The Kalman filter has been evaluated through simulations. This evaluation and some unusual features of the filter are discussed. In the second step, we perform a geophysical inversion using a linear Bayesian estimator. To allow an unbiased comparison between gravity and topography, we use a simulation technique to smooth and distort the radar topographic data so as to yield maps having the same characteristics as our gravity maps. The maps presented cover 2/3 of the surface of Venus and display the strong topography-gravity correlation previously reported. The topography-gravity scatter plots show two distinct trends.

  19. Venus: radar determination of gravity potential. (United States)

    Shapiro, I I; Pettengill, G H; Sherman, G N; Rogers, A E; Ingalls, R P


    We describe a method for the determination of the gravity potential of Venus from multiple-frequency radar measurements. The method is based on the strong frequency dependence of the absorption of radio waves in Venus' atmosphere. Comparison of the differing radar reflection intensities at several frequencies yields the height of the surface relative to a reference pressure contour; combination with measurements of round-trip echo delays allows the pressure, and hence the gravity potential contour, to be mapped relative to the mean planet radius. Since calibration data from other frequencies are unavailable, the absorption-sensitive Haystack Observatory data have been analyzed under the assumption of uniform surface reflectivity to yield a gravity equipotential contour for the equatorial region and a tentative upper bound of 6 x 10(-4) on the fractional difference of Venus' principal equatorial moments of inertia. The minima in the equipotential contours appear to be associated with topographic minima.

  20. Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.


    Flavell, D M; Wells, T; Wells, S E; Carmignac, D F; Thomas, G B; Robinson, I C


    Expression of human growth hormone (hGH) was targeted to growth hormone-releasing (GRF) neurons in the hypothalamus of transgenic rats. This induced dominant dwarfism by local feedback inhibition of GRF. One line, bearing a single copy of a GRF-hGH transgene, has been characterized in detail, and has been termed Tgr (for Transgenic growth-retarded). hGH was detected by immunocytochemistry in the brain, restricted to the median eminence of the hypothalamus. Low levels were also detected in the...

  1. Impaired leptin gene expression and release in cultured preadipocytes isolated from individuals born with low birth weight

    DEFF Research Database (Denmark)

    Schultz, Ninna S; Broholm, Christa; Gillberg, Linn


    controls born with normal birth weight (NBW). Biopsies were obtained from subcutaneous abdominal fat depots and preadipocytes were isolated and cultured. Gene expression of leptin and selected differentiation markers were analyzed during preadipocyte differentiation and cell culture media was collected......Low birth weight (LBW) is associated with increased risk of developing type 2 diabetes (T2D). The appetite-regulating hormone leptin is released from mature adipocytes and its production may be decreased in immature preadipocytes from LBW individuals. We recruited 14 men born with LBW and 13...

  2. Venus project : experimentation at ENEA`s pilot site

    Energy Technology Data Exchange (ETDEWEB)

    Bargellini, M L; Fontana, F [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dip. Innovazione; Bucci, C; Ferrara, F; Sottile, P A [GESI s.r.l., Rome (Italy); Niccolai, L; Scavino, G [Rome Univ. Sacro Cuore (Italy); Mancini, R; Levialdi, S [Rome Univ. La Sapienza (Italy). Dip. di Scienze dell` Informazione


    The document describes the ENEA`s (Italian Agency for New Technologies, Energy and the Environment) experience in the Venus Project (Esprit III ). Venus is an advanced visual interface based on icon representation that permits to end-user to inquiry databases. VENUS interfaces to ENEA`s databases: cometa materials Module, Cometa Laboratories Module and European Programs. This report contents the results of the experimentation and of the validation carried out in ENEA`s related to the Venus generations. Moreover, the description of the architecture, the user requirements syntesis and the validation methodology of the VENUS systems have been included.

  3. Can Venus magnetosheath plasma evolve into turbulence? (United States)

    Dwivedi, Navin; Schmid, Daniel; Narita, Yasuhito; Volwerk, Martin; Delva, Magda; Voros, Zoltan; Zhang, Tielong


    The present work aims to understand turbulence properties in planetary magnetosheath regions to obtain physical insight on the energy transfer from the larger to smaller scales, in spirit of searching for power-law behaviors in the spectra which is an indication of the energy cascade and wave-wave interaction. We perform a statistical analysis of energy spectra using the Venus Express spacecraft data in the Venusian magnetosheath. The fluxgate magnetometer data (VEXMAG) calibrated down to 1 Hz as well as plasma data from the ion mass analyzer (ASPERA) aboard the spacecraft are used in the years 2006-2009. Ten-minute intervals in the magnetosheath are selected, which is typical time length of observations of quasi-stationary fluctuations avoiding multiple boundaries crossings. The magnetic field data are transformed into the mean-field-aligned (MFA) coordinate system with respect to the large-scale magnetic field direction and the energy spectra are evaluated using a Welch algorithm in the frequency range between 0.008 Hz and 0.5 Hz for 105 time intervals. The averaged energy spectra show a power law upto 0.3 Hz with the approximate slope of -1, which is flatter than the Kolmogorov slope, -5/3. A slight hump in the spectra is found in the compressive component near 0.3 Hz, which could possibly be realization of mirror mode in the magnetosheath. A spectral break (sudden change in slope) accompanies the spectral hump at 0.4 Hz, above which the spectral curve becomes steeper. The overall spectral shape is reminiscent of turbulence. The low-frequency part with the slope -1 is interpreted as realization of the energy containing range, while the high-frequency part with the steepening is interpreted either as the beginning of energy cascade mediated by mirror mode or as the dissipation range due to wave-particle resonance processes. The present research work is fully supported by FP7/STORM (313038).

  4. Investigating the Geophysics of Venus: Result of the post-Alpbach Summer School 2014 (United States)

    Koopmans, Robert-Jan; Łosiak, Anna; Białek, Agata; Donohoe, Anthony; Fernández Jiménez, María; Frasl, Barbara; Gurciullo, Antonio; Kleinschneider, Andreas; Mannel, Thurid; Muñoz Elorza, Iñigo; Nilsson, Daniel; Oliveira, Marta; Sørensen-Clark, Paul; Timoney, Ryan; van Zelst, Iris


    heat signatures from volcanoes. By using the previous landers as reference points it will also be possible to accurately determine the spin rate with the radar. The nominal mission duration is planned to be five years starting from the release of the balloon. The balloon will operate for 25 days during which it oscillates vertically in the atmosphere between an altitude of 40 and 60 kilometres in a period of about six hours. At the same time, due to prevailing wind directions on Venus, it will gradually spiral from the equator towards higher latitudes. During the balloon science phase the orbiter will be in an elliptical orbit to maximise the time of visibility of the balloon with the orbiter. After this phase, the orbiter will be brought into a circular orbit at an altitude of 250 kilometres. To save fuel, apoapsis lowering will be achieved by aerobreaking in Venus' atmosphere. In the presentation further details about the mission timeline will be given. Particular engineering problems such as thermal control and data communication and the proposed solutions will be presented.

  5. Galileo infrared imaging spectroscopy measurements at venus (United States)

    Carlson, R.W.; Baines, K.H.; Encrenaz, Th.; Taylor, F.W.; Drossart, P.; Kamp, L.W.; Pollack, James B.; Lellouch, E.; Collard, A.D.; Calcutt, S.B.; Grinspoon, D.; Weissman, P.R.; Smythe, W.D.; Ocampo, A.C.; Danielson, G.E.; Fanale, F.P.; Johnson, T.V.; Kieffer, H.H.; Matson, D.L.; McCord, T.B.; Soderblom, L.A.


    During the 1990 Galileo Venus flyby, the Near Infrared Mapping Spectrometer investigated the night-side atmosphere of Venus in the spectral range 0.7 to 5.2 micrometers. Multispectral images at high spatial resolution indicate substantial cloud opacity variations in the lower cloud levels, centered at 50 kilometers altitude. Zonal and meridional winds were derived for this level and are consistent with motion of the upper branch of a Hadley cell. Northern and southern hemisphere clouds appear to be markedly different. Spectral profiles were used to derive lower atmosphere abundances of water vapor and other species.

  6. Antidepressant effects of abscisic acid mediated by the downregulation of corticotrophin-releasing hormone gene expression in rats. (United States)

    Qi, Cong-Cong; Zhang, Zhi; Fang, Hui; Liu, Ji; Zhou, Nan; Ge, Jin-Fang; Chen, Fang-Han; Xiang, Cheng-Bin; Zhou, Jiang-Ning


    Corticotrophin-releasing hormone (CRH) is considered to be the central driving force of the hypothalamic-pituitary-adrenal axis, which plays a key role in the stress response and depression. Clinical reports have suggested that excess retinoic acid (RA) is associated with depression. Abscisic acid (ABA) and RA are direct derivatives of carotenoids and share a similar molecular structure. Here, we proposed that ABA also plays a role in the regulation of CRH activity sharing with the RA signaling pathway. [3H]-ABA radioimmunoassay demonstrated that the hypothalamus of rats shows the highest concentration of ABA compared with the cortex and the hippocampus under basal conditions. Under acute stress, ABA concentrations increased in the serum, but decreased in the hypothalamus and were accompanied by increased corticosterone in the serum and c-fos expression in the hypothalamus. Moreover, chronic ABA administration increased sucrose intake and decreased the mRNA expression of CRH and retinoic acid receptor alpha (RARα) in the hypothalamus of rats. Furthermore, ABA improved the symptom of chronic unpredictable mild stress in model rats, as indicated by increased sucrose intake, increased swimming in the forced swim test, and reduced mRNA expression of CRH and RARα in the rat hypothalamus. In vitro, CRH expression decreased after ABA treatment across different neural cells. In BE(2)-C cells, ABA inhibited a series of retinoid receptor expression, including RARα, a receptor that could facilitate CRH expression directly. These results suggest that ABA may play a role in the pathogenesis of depression by downregulating CRH mRNA expression shared with the RA signaling pathway. © The Author 2014. Published by Oxford University Press on behalf of CINP.

  7. Corticotropin-releasing factor receptor types 1 and 2 are differentially expressed in pre- and post-synaptic elements in the post-natal developing rat cerebellum

    NARCIS (Netherlands)

    Swinny, JD; Kalicharan, D; Blaauw, EH; Ijkema-Paassen, J; Shi, F; Gramsbergen, A; van der Want, JJL

    Corticotropin-releasing factor (CRF)-like proteins act via two G-protein-coupled receptors (CRF-R1 and CRF-R2) playing important neuromodulatory roles in stress responses and synaptic plasticity. The cerebellar expression of corticotropin-releasing factor-like ligands has been well documented, but

  8. Degraded expression of learned feedforward control in movements released by startle. (United States)

    Wright, Zachary A; Carlsen, Anthony N; MacKinnon, Colum D; Patton, James L


    Recent work has shown that preplanned motor programs can be rapidly released via fast conducting pathways using a startling acoustic stimulus. Our question was whether the startle-elicited response might also release a recently learned internal model, which draws on experience to predict and compensate for expected perturbations in a feedforward manner. Our initial investigation using adaptation to robotically produced forces showed some evidence of this, but the results were potentially confounded by co-contraction caused by startle. In this study, we eliminated this confound by asking subjects to make reaching movements in the presence of a visual distortion. Results show that a startle stimulus (1) decreased performance of the recently learned task and (2) reduced after-effect magnitude. Since the recall of learned control was reduced, but not eliminated during startle trials, we suggest that multiple neural centers (cortical and subcortical) are involved in such learning and adaptation. These findings have implications for motor training in areas such as piloting, teleoperation, sports, and rehabilitation.

  9. Stimulated serotonin release from hyperinnervated terminals subsequent to neonatal dopamine depletion regulates striatal tachykinin, but not enkephalin gene expression. (United States)

    Basura, G J; Walker, P D


    Dopamine (DA) depletion in neonatal rodents results in depressed tachykinin and elevated enkephalin gene expression in the adult striatum (STR). Concurrently, serotonin (5-HT) fibers sprout to hyperinnervate the DA-depleted anterior striatum (A-STR). The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR. Three-day-old Sprague-Dawley rat pups received bilateral intracerebroventricular injections of vehicle or the DA neurotoxin 6-hydroxydopamine (6-OHDA, 100 microg). Two months later, rats received a single intraperitoneal injection of vehicle or the acute 5-HT releasing agent p-chloroamphetamine (PCA; 10 mg/kg). Rats were killed 4 h later and striata processed for monoamine content by HPLC-ED and mRNA expression by in situ hybridization within specific subregions of the A-STR and posterior striatum (P-STR). 6-OHDA treatment severely (>98%) reduced striatal DA levels, while 5-HT content in the A-STR was significantly elevated (doubled), indicative of 5-HT hyperinnervation. Following 6-OHDA, PPT mRNA levels were depressed 60-66% across three subregions of the A-STR and 52-59% across two subregions of the P-STR, while PPE mRNA expression was elevated in both the A-STR (50-62%) and P-STR (55-82%). PCA normalized PPT mRNA levels in all regions of the DA-depleted A-STR and P-STR, yet did not alter PPE levels in either dorsal central or medial regions from 6-OHDA alone, but reduced PPE to control levels in the dorsal lateral A-STR. These data indicate that increased 5-HT neurotransmission, following neonatal 6-OHDA treatment, primarily influences PPT-containing neurons of the direct striatal output pathway.

  10. Astrobiology: The Case for Venus (United States)

    Landis, Geoffrey A.


    The scientific discipline of astrobiology addresses one of the most fundamental unanswered questions of science: are we alone? Is there life elsewhere in the universe, or is life unique to Earth? The field of astrobiology includes the study of the chemical precursors for life in the solar system; it also includes the search for both presently existing life and fossil signs of previously existing life elsewhere in our own solar system, as well as the search for life outside the solar system. Two of the promising environments within the solar system being currently considered are the surface of the planet Mars, and the hypothesized oceans underneath the ice covering the moon Europa. Both of these environments differ in several key ways from the environments where life is found on Earth; the Mars environment in most places too cold and at too low pressure for liquid water to be stable, and the sub-ice environment of Europa lacking an abundance of free energy in the form of sunlight. The only place in the solar system where we know that life exists today is the Earth. To look for life elsewhere in the solar system, one promising search strategy would be to find and study the environment in the solar system with conditions that are most similar to the environmental conditions where life thrives on the Earth. Specifically, we would like to study a location in the solar system with atmospheric pressure near one bar; temperature in the range where water is liquid, 0 to 100 C; abundant solar energy; and with the primary materials required for life, carbon, oxygen, nitrogen, and hydrogen, present. Other than the surface of the Earth, the only other place where these conditions exist is the atmosphere of Venus, at an altitude of about fifty kilometers above the surface.

  11. Reduction-sensitive lipopolyamines as a novel nonviral gene delivery system for modulated release of DNA with improved transgene expression. (United States)

    Byk, G; Wetzer, B; Frederic, M; Dubertret, C; Pitard, B; Jaslin, G; Scherman, D


    We have designed and synthesized original cationic lipids for modulated release of DNA from cationic lipid/DNA complexes. Our rationale was that modulated degradation of the lipids during or after penetration into the cell could improve the trafficking of DNA to the nucleus resulting in increased transgene expression. The new reduction-sensitive lipopolyamines (RSL) harbor a disulfide bridge within different positions in the backbone of the lipids as biosensitive function. A useful synthetic method was developed to obtain, with very good yields and reproducibility, unsymmetrical disulfide-bridged molecules, starting from symmetrical disulfides and thiols. The new lipopolyamines are good candidates as carriers of therapeutic genes for in vivo gene delivery. To optimize the transfection efficiency in these novel series, we have carried out structure-activity relationship studies by placing the disulfide bridge at different positions in the backbone of the cationic lipid and by systematic variation of lipid chain length. Results indicate that the transfection level can be modulated as a function of the location of the disulfide bridge in the molecule. We suggest that an early release of DNA during or after penetration into the cell, probably promoted by reduction of a disulfide bridge placed between the polyamine and the lipid, implies a total loss of transfection efficiency. On the other hand, proper modulation of DNA release by inserting the disulfide bridge between one lipid chain and the rest of the molecule brings about increased transfection efficiency as compared to previously described nondegradable lipopolyamine analogues. Finally, preliminary physicochemical characterization of the complexes demonstrates that DNA release from complexes can be modulated as a function of the surrounding reducing conditions of the complexes and of the localization of the disulfide bridge within the lipopolyamine. Our results suggest that RSL is a promising new approach for gene

  12. Practical Observations of the Transit of Venus

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 5. Practical Observations of the Transit of Venus. B S Shyalaja. Classroom Volume 9 Issue 5 May 2004 pp 79-83. Fulltext. Click here to view fulltext PDF. Permanent link: ...

  13. Tidal constraints on the interior of Venus (United States)

    Dumoulin, C.; Tobie, G.; Verhoeven, O.; Rosenblatt, P.; Rambaux, N.


    As a prospective study for a future exploration of Venus, we compute the tidal response of Venus' interior assuming various mantle compositions and temperature profiles representative of different scenarios of Venus' formation and evolution. The mantle density and seismic velocities are modeled from thermodynamical equilibria of mantle minerals and used to predict the moment of inertia, Love numbers, and tide-induced phase lag characterizing the signature of the internal structure in the gravity field. The viscoelasticity of the mantle is parameterized using an Andrade rheology. From the models considered here, the moment of inertia lies in the range of 0.327 to 0.342, corresponding to a core radius of 2900 to 3450 km. Viscoelasticity of the mantle strongly increases the potential Love number relative to previously published elastic models. Due to the anelasticity effects, we show that the possibility of a completely solid metal core inside Venus cannot be ruled out based on the available estimate of k2 from the Magellan mission (Konopliv and Yoder, 1996). A Love number k2 lower than 0.27 would indicate the presence of a fully solid iron core, while for larger values, solutions with an entirely or partially liquid core are possible. Precise determination of the Love numbers, k2 and h2, together with an estimate of the tidal phase lag, are required to determine the state and size of the core, as well as the composition and viscosity of the mantle.

  14. 10. The surface and interior of venus (United States)

    Masursky, H.; Kaula, W.M.; McGill, G.E.; Pettengill, G.H.; Phillips, R.J.; Russell, C.T.; Schubert, G.; Shapiro, I.I.


    Present ideas about the surface and interior of Venus are based on data obtained from (1) Earth-based radio and radar: temperature, rotation, shape, and topography; (2) fly-by and orbiting spacecraft: gravity and magnetic fields; and (3) landers: winds, local structure, gamma radiation. Surface features, including large basins, crater-like depressions, and a linear valley, have been recognized from recent ground-based radar images. Pictures of the surface acquired by the USSR's Venera 9 and 10 show abundant boulders and apparent wind erosion. On the Pioneer Venus 1978 Orbiter mission, the radar mapper experiment will determine surface heights, dielectric constant values and small-scale slope values along the sub-orbital track between 50??S and 75??N. This experiment will also estimate the global shape and provide coarse radar images (40-80 km identification resolution) of part of the surface. Gravity data will be obtained by radio tracking. Maps combining radar altimetry with spacecraft and ground-based images will be made. A fluxgate magnetometer will measure the magnetic fields around Venus. The radar and gravity data will provide clues to the level of crustal differentiation and tectonic activity. The magnetometer will determine the field variations accurately. Data from the combined experiments may constrain the dynamo mechanism; if so, a deeper understanding of both Venus and Earth will be gained. ?? 1977 D. Reidel Publishing Company.

  15. Abrir una Venus: Hablar con ella

    Directory of Open Access Journals (Sweden)

    Ginnette Barrantes Sáenz


    Se propone a Alicia como la Venus abierta que  incita, mediante  la  cita cinematográfica del cine mudo en el cine de Almodóvar, la no tan conocida figura de  amar a una  dormida( Allouch, 2005

  16. Solar Airplane Concept Developed for Venus Exploration (United States)

    Landis, Geoffrey A.


    An airplane is the ideal vehicle for gathering atmospheric data over a wide range of locations and altitudes, while having the freedom to maneuver to regions of scientific interest. Solar energy is available in abundance on Venus. Venus has an exoatmospheric solar flux of 2600 W/m2, compared with Earth's 1370 W/m2. The solar intensity is 20 to 50 percent of the exoatmospheric intensity at the bottom of the cloud layer, and it increases to nearly 95 percent of the exoatmospheric intensity at 65 km. At these altitudes, the temperature of the atmosphere is moderate, in the range of 0 to 100 degrees Celsius, depending on the altitude. A Venus exploration aircraft, sized to fit in a small aeroshell for a "Discovery" class scientific mission, has been designed and analyzed at the NASA Glenn Research Center. For an exploratory aircraft to remain continually illuminated by sunlight, it would have to be capable of sustained flight at or above the wind speed, about 95 m/sec at the cloud-top level. The analysis concluded that, at typical flight altitudes above the cloud layer (65 to 75 km above the surface), a small aircraft powered by solar energy could fly continuously in the atmosphere of Venus. At this altitude, the atmospheric pressure is similar to pressure at terrestrial flight altitudes.

  17. The expression of gonadotropin releasing hormone receptor gene in ovaries and uterus cells of Iraqi and Damascus goat breed

    Directory of Open Access Journals (Sweden)

    Alaa kamil Abdulla


    Full Text Available Iraqi goats have a major economic role in production of meat, milk and leather as well as it considered a financial source for owners as reproduce twice a year, yet the Damascus goats have great importance than Iraqi goats owing to the number of twin births. The gonadotropin releasing hormone (GnRH and its receptors have great importance in the reproduction and eugenics. To make a comparison between the Iraqi and Damascus goats in terms of this receptor gene expression in the ovaries and uterus tissue cells, the study was performed, in which used the (∆Ct Using a Reference Gene method by quintitive -real time PCR technique. Results were found a significant difference (p<0.05, as the gene expression of (GnRH-R higher in the ovaries and uterus tissue cells in Damascus goats compared with the Iraqi goats. In conclusion; the multiple pregnancies of twins in Damascus goats may be due to an increase gene expression of (GnRH-R in the ovaries and uterus tissue

  18. Chronic traumatic stress impairs memory in mice: Potential roles of acetylcholine, neuroinflammation and corticotropin releasing factor expression in the hippocampus. (United States)

    Bhakta, Ami; Gavini, Kartheek; Yang, Euitaek; Lyman-Henley, Lani; Parameshwaran, Kodeeswaran


    Chronic stress in humans can result in multiple adverse psychiatric and neurobiological outcomes, including memory deficits. These adverse outcomes can be more severe if each episode of stress is very traumatic. When compared to acute or short term stress relatively little is known about the effects of chronic traumatic stress on memory and molecular changes in hippocampus, a brain area involved in memory processing. Here we studied the effects of chronic traumatic stress in mice by exposing them to adult Long Evan rats for 28 consecutive days and subsequently analyzing behavioral outcomes and the changes in the hippocampus. Results show that stressed mice developed memory deficits when assayed with radial arm maze tasks. However, chronic traumatic stress did not induce anxiety, locomotor hyperactivity or anhedonia. In the hippocampus of stressed mice interleukin-1β protein expression was increased along with decreased corticotropin releasing hormone (CRH) gene expression. Furthermore, there was a reduction in acetylcholine levels in the hippocampus of stressed mice. There were no changes in brain derived neurotrophic factor (BDNF) or nerve growth factor (NGF) levels in the hippocampus of stressed mice. Gene expression of immediate early genes (Zif268, Arc, C-Fos) as well as glucocorticoid and mineralocorticoid receptors were also not affected by chronic stress. These data demonstrate that chronic traumatic stress followed by a recovery period might lead to development of resilience resulting in the development of selected, most vulnerable behavioral alterations and molecular changes in the hippocampus. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. A 3D Multi-fluid MHD Study of the Interaction of the Solar Wind with the Ionosphere/Atmosphere System of Venus. (United States)

    Najib, D.; Nagy, A.; Toth, G.; Ma, Y.-J.


    We use the latest version of our four species multifluid model to study the interaction of the solar wind with Venus. The model solves simultaneously the continuity, momentum and energy equations of the different ions. The lower boundary of our model is at 100 km, below the main ionospheric peak, and the radial resolution is about 10 km in the ionosphere, thus the model does a very good job in reproducing the ionosphere and the associated processes. We carry out calculations for high and low solar activity conditions and establish the importance of mass loading by the extended exosphere of Venus. We demonstrate the importance of using the multi-fluid rather than a single fluid model. We also calculate the atmospheric escape of the ionospheric species and compare our model results with the observed parameters from Pioneer Venus and Venus Express.

  20. A correlated-k model of radiative transfer in the near-infrared windows of Venus

    International Nuclear Information System (INIS)

    Tsang, C.C.C.; Irwin, P.G.J.; Taylor, F.W.; Wilson, C.F.


    We present a correlated-k-based model for generating synthetic spectra in the near-infrared window regions, from 1.0 to 2.5 μm, emitted from the deep atmosphere of Venus on the nightside. This approach is applicable for use with any near-infrared instrument, ground-based and space-borne, for analysis of the thermal emissions in this spectral range. We also approach this work with the view of using the model, in conjunction with a retrieval algorithm, to retrieve minor species from the Venus Express/VIRTIS instrument. An existing radiative-transfer model was adapted for Venusian conditions to deal with the prevailing high pressures and temperatures and other conditions. A comprehensive four-modal cloud structure model based on Pollack et al. [Near-infrared light from venus' nightside: a spectroscopic analysis. Icarus 1993;103:1-42], using refractive indices for a 75% H 2 SO 4 25% H 2 O mixture from Palmer and Williams [Optical constants of sulfuric acid; application to the clouds of Venus? Appl Opt 1975;14(1):208-19], was also implemented. We then utilized a Mie scattering algorithm to account for the multiple scattering effect between cloud and haze layers that occur in the Venusian atmosphere. The correlated-k model is shown to produce good agreement with ground-based spectra of Venus in the near infrared, and to match the output from a line-by-line radiative-transfer model to better than 10%

  1. Venus: The Atmosphere, Climate, Surface, Interior and Near-Space Environment of an Earth-Like Planet (United States)

    Taylor, Fredric W.; Svedhem, Håkan; Head, James W.


    This is a review of current knowledge about Earth's nearest planetary neighbour and near twin, Venus. Such knowledge has recently been extended by the European Venus Express and the Japanese Akatsuki spacecraft in orbit around the planet; these missions and their achievements are concisely described in the first part of the review, along with a summary of previous Venus observations. The scientific discussions which follow are divided into three main sections: on the surface and interior; the atmosphere and climate; and the thermosphere, exosphere and magnetosphere. These reports are intended to provide an overview for the general reader, and also an introduction to the more detailed topical surveys in the following articles in this issue, where full references to original material may be found.

  2. The importance of being Florentine: a journey around the world for wax anatomical Venuses. (United States)

    de Ceglia, Francesco Paolo


    This article reconstructs the 19th century history of events regarding a few female wax anatomical models made in Florence. More or less faithful copies of those housed in Florence's Museum of Physics and Natural History, these models were destined for display in temporary exhibitions. In their travels through Europe and the United States, they transformed the expression "Florentine Venus" into a sort of brand name used to label and offer respectability to pieces of widely varying quality.

  3. Effects of corticotropin-releasing hormone and its antagonist on the gene expression of gonadotrophin-releasing hormone (GnRH) and GnRH receptor in the hypothalamus and anterior pituitary gland of follicular phase ewes. (United States)

    Ciechanowska, Magdalena; Łapot, Magdalena; Malewski, Tadeusz; Mateusiak, Krystyna; Misztal, Tomasz; Przekop, Franciszek


    There is no information in the literature regarding the effect of corticotropin-releasing hormone (CRH) on genes encoding gonadotrophin-releasing hormone (GnRH) and the GnRH receptor (GnRHR) in the hypothalamus or on GnRHR gene expression in the pituitary gland in vivo. Thus, the aim of the present study was to investigate, in follicular phase ewes, the effects of prolonged, intermittent infusion of small doses of CRH or its antagonist (α-helical CRH 9-41; CRH-A) into the third cerebral ventricle on GnRH mRNA and GnRHR mRNA levels in the hypothalamo-pituitary unit and on LH secretion. Stimulation or inhibition of CRH receptors significantly decreased or increased GnRH gene expression in the hypothalamus, respectively, and led to different responses in GnRHR gene expression in discrete hypothalamic areas. For example, CRH increased GnRHR gene expression in the preoptic area, but decreased it in the hypothalamus/stalk median eminence and in the anterior pituitary gland. In addition, CRH decreased LH secretion. Blockade of CRH receptors had the opposite effect on GnRHR gene expression. The results suggest that activation of CRH receptors in the hypothalamus of follicular phase ewes can modulate the biosynthesis and release of GnRH through complex changes in the expression of GnRH and GnRHR genes in the hypothalamo-anterior pituitary unit. © CSIRO 2011 Open Access

  4. The Venus Emissivity Mapper - gaining a global perspective on the surface composition of Venus (United States)

    Helbert, Joern; Dyar, Melinda; Widemann, Thomas; Marcq, Emmanuel; Maturilli, Alessandro; Mueller, Nils; Kappel, David; Ferrari, Sabrina; D'Amore, Mario; Tsang, Constantine; Arnold, Gabriele; Smrekar, Suzanne; VEM Team


    The permanent cloud cover of Venus prohibits observations of the surface with traditional imaging techniques over much of the EM spectral range, leading to the false notion that information about the composition of Venus’ surface could only be derived from lander missions. However, harsh environmental conditions on the surface cause landed missions to be sole site, highly complex, and riskier than orbiting missions.It is now known that 5 transparency windows occur in the Venus atmosphere, ranging from 0.86 µm to 1.18 µm. Recent advances in high temperature laboratory spectroscopy at the PSL at DLR these windows are highly diagnostic for surface mineralogy. Mapping of the southern hemisphere of Venus with VIRTIS on VEX in the 1.02 µm band was a proof-of-concept for an orbital remote sensing approach to surface composition and weathering studies[1-3]. The Venus Emissivity Mapper [4] proposed for the NASA’s Venus Origins Explorer (VOX) and the ESA EnVision proposal builds on these recent advances. It is the first flight instrument specially designed with a sole focus on mapping the surface of Venus using the narrow atmospheric windows around 1 µm. Operating in situ from Venus orbit, VEM will provide a global map of surface composition as well as redox state of the surface, providing a comprehensive picture of surface-atmosphere interaction and support for landing site selection. Continuous observation of the thermal emission of the Venus will provide tight constraints on the current day volcanic activity[5]. This is complemented by measurements of atmospheric water vapor abundance as well as cloud microphysics and dynamics. These data will allow for accurate correction of atmospheric interference on the surface measurements, which provide highly valuable science on their own. A mission combining VEM with a high-resolution radar mapper such as VOX or EnVision in a low circular orbit will provide key insights into the divergent evolution of Venus.1. Smrekar, S

  5. MEETING VENUS. A Collection of Papers presented at the Venus Transit Conference Tromsoe 2012 (United States)

    Sterken, Christiaan; Aspaas, Per Pippin


    On 2-3 June 2012, the University of Tromsoe hosted a conference about the cultural and scientific history of the transits of Venus. The conference took place in Tromsoe for two very specific reasons. First and foremost, the last transit of Venus of this century lent itself to be observed on the disc of the Midnight Sun in this part of Europe during the night of 5 to 6 June 2012. Second, several Venus transit expeditions in this region were central in the global enterprise of measuring the scale of the solar system in the eighteenth century. The site of the conference was the Nordnorsk Vitensenter (Science Centre of Northern Norway), which is located at the campus of the University of Tromsoe. After the conference, participants were invited to either stay in Tromsoe until the midnight of 5-6 June, or take part in a Venus transit voyage in Finnmark, during which the historical sites Vardoe, Hammerfest, and the North Cape were to be visited. The post-conference program culminated with the participants observing the transit of Venus in or near Tromsoe, Vardoe and even from a plane near Alta. These Proceedings contain a selection of the lectures delivered on 2-3 June 2012, and also a narrative description of the transit viewing from Tromsoe, Vardoe and Alta. The title of the book, Meeting Venus, refers the title of a play by the Hungarian film director, screenwriter and opera director Istvan Szabo (1938-). The autobiographical movie Meeting Venus (1991) directed by him is based on his experience directing Tannhauser at the Paris Opera in 1984. The movie brings the story of an imaginary international opera company that encounters a never ending series of difficulties and pitfalls that symbolise the challenges of any multicultural and international endeavour. As is evident from the many papers presented in this book, Meeting Venus not only contains the epic tales of the transits of the seventeenth, eighteenth and nineteenth centuries, it also covers the conference

  6. Corticotropin-releasing hormone expression in patients with intrahepatic cholestasis of pregnancy after ursodeoxycholic acid treatment: an initial experience. (United States)

    Zhou, Fan; Zhang, Li; He, Mao Mao; Liu, Zheng Fei; Gao, Bing Xin; Wang, Xiao Dong


    Corticotropin-releasing hormone (CRH) is one of the most potent vasodilatory factors in the human feto-placental circulation. The expression of CRH was significantly down-regulated in patients with intrahepatic cholestasis of pregnancy (ICP). One hundred pregnant women diagnosed with ICP at 34-34(+6) weeks of gestation agreed to participate in this prospective nested case-control study. Thirty ICP patients were finally recruited in this study, with 16 cases in the ursodeoxycholic acid (UDCA) group (UDCA 750 mg/d) and 14 cases in the control group (Transmetil 1000 mg/d or Essentiale 1368 mg/d). Maternal serum samples were obtained in diagnosis and at 37-37(+6) weeks of gestation. Placental tissues were obtained from participants after delivery. ELISA, enzymatic colorimetric and Western blotting were used to evaluate the concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA) and CRH in maternal serum and expression of CRH in placenta tissues. The UDCA group had greater reduction in maternal serum ALT, AST and TBA levels in ICP patients (all p < 0.01). Maternal serum CRH concentrations in the UDCA group after treatment (122.10 ± 44.20) pg/ml was significantly higher than pretreatment (95.45 ± 26.47) pg/ml (p < 0.01). After treatment, maternal serum CRH concentrations of the UDCA group (122.10 ± 44.20) pg/ml was significantly higher than in the control group (80.71 ± 41.10) pg/ml (p < 0.01). Placental CRH expression in the UDCA group (2.79 ± 1.72) was significantly higher than in the control group (0.69 ± 0.36) (p < 0.01). Maternal serum and placental CRH expression in ICP patients were up-regulated after treatment of UDCA. The up-regulation of CRH expression after UDCA treatment may play an important role in the therapeutic mechanism of ICP. All patients recruited in this study had severe cholestasis (TBA ≥ 40 µmol/L). Further studies are warranted in

  7. The escape of natural satellites from Mercury and Venus

    International Nuclear Information System (INIS)

    Kumar, S.S.


    It is suggested that the slow rotations of Mercury and Venus may be connected with the absence of natural satellites around them. If Mercury or Venus possessed a satellite at the time of formation, the tidal evolution would have caused the satellite to recede. At a sufficiently large distance from the planet, the Sun's gravitational influence makes the satellite orbit unstable. The natural satellites of Mercury and Venus might have escaped as a consequence of this instability. (Auth.)

  8. Escape of natural satellites from Mercury and Venus

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S S [Virginia Univ., Charlottesville (USA)


    It is suggested that the slow rotations of Mercury and Venus may be connected with the absence of natural satellites around them. If Mercury or Venus possessed a satellite at the time of formation, the tidal evolution would have caused the satellite to recede. At a sufficiently large distance from the planet, the Sun's gravitational influence makes the satellite orbit unstable. The natural satellites of Mercury and Venus might have escaped as a consequence of this instability.

  9. The ETRAMP family member SEP2 is expressed throughout Plasmodium berghei life cycle and is released during sporozoite gliding motility. (United States)

    Currà, Chiara; Di Luca, Marco; Picci, Leonardo; de Sousa Silva Gomes dos Santos, Carina; Siden-Kiamos, Inga; Pace, Tomasino; Ponzi, Marta


    The early transcribed membrane proteins ETRAMPs belong to a family of small, transmembrane molecules unique to Plasmodium parasite, which share a signal peptide followed by a short lysine-rich stretch, a transmembrane domain and a variable, highly charged C-terminal region. ETRAMPs are usually expressed in a stage-specific manner. In the blood stages they localize to the parasitophorous vacuole membrane and, in described cases, to vesicle-like structures exported to the host erythrocyte cytosol. Two family members of the rodent parasite Plasmodium berghei, uis3 and uis4, localize to secretory organelles of sporozoites and to the parasitophorous membrane vacuole of the liver stages. By the use of specific antibodies and the generation of transgenic lines, we showed that the P. berghei ETRAMP family member SEP2 is abundantly expressed in gametocytes as well as in mosquito and liver stages. In intracellular parasite stages, SEP2 is routed to the parasitophorous vacuole membrane while, in invasive ookinete and sporozoite stages, it localizes to the parasite surface. To date SEP2 is the only ETRAMP protein detected throughout the parasite life cycle. Furthermore, SEP2 is also released during gliding motility of salivary gland sporozoites. A limited number of proteins are known to be involved in this key function and the best characterized, the CSP and TRAP, are both promising transmission-blocking candidates. Our results suggest that ETRAMP members may be viewed as new potential candidates for malaria control.

  10. First stage of cosmic expedition Vega: Venus investigations

    International Nuclear Information System (INIS)

    Balebanov, V.M.; Moroz, V.I.; Mukhin, L.M.


    Main results of the first (Venus) stage of the international complex program ''Venus - Halley'' (''Vega'' for short) are presented. The program is aimed at transporting descent space vehicles to the Venus to explore its atmosphere and surface. Then automatic interplanetary stations (AIS) will be directed to the Halley's comet. In June 1985 the descent space vehicles AIS ''Vega-1'' and ''Vega-2'' have landed softly on the Venus surface, aerostat probes have been launched to the planet atmosphere. The design of the descent space vehicle, structure and chemical composition of the atmosphere, ground composition are briefly outlined

  11. Energetic particles at venus: galileo results. (United States)

    Williams, D J; McEntire, R W; Krimigis, S M; Roelof, E C; Jaskulek, S; Tossman, B; Wilken, B; Stüdemann, W; Armstrong, T P; Fritz, T A; Lanzerotti, L J; Roederer, J G


    At Venus the Energetic Particles Detector (EPD) on the Galileo spacecraft measured the differential energy spectra and angular distributions of ions >22 kiloelectron volts (keV) and electrons > 15 keV in energy. The only time particles were observed by EPD was in a series of episodic events [0546 to 0638 universal time (UT)] near closest approach (0559:03 UT). Angular distributions were highly anisotropic, ordered by the magnetic field, and showed ions arriving from the hemisphere containing Venus and its bow shock. The spectra showed a power law form with intensities observed into the 120- to 280-keV range. Comparisons with model bow shock calculations show that these energetic ions are associated with the venusian foreshock-bow shock region. Shock-drift acceleration in the venusian bow shock seems the most likely process responsible for the observed ions.

  12. Electron plasma oscillations in the Venus foreshock (United States)

    Crawford, G. K.; Strangeway, R. J.; Russell, C. T.


    Plasma waves are observed in the solar wind upstream of the Venus bow shock by the Pioneer Venus Orbiter. These wave signatures occur during periods when the interplanetary magnetic field through the spacecraft position intersects the bow shock, thereby placing the spacecraft in the foreshock region. The electron foreshock boundary is clearly evident in the data as a sharp onset in wave activity and a peak in intensity. Wave intensity is seen to drop rapidly with increasing penetration into the foreshock. The peak wave electric field strength at the electron foreshock boundary is found to be similar to terrestrial observations. A normalized wave spectrum was constructed using measurements of the electron plasma frequency and the spectrum was found to be centered about this value. These results, along with polarization studies showing the wave electric field to be field aligned, are consistent with the interpretation of the waves as electron plasma oscillations.

  13. Electron plasma oscillations in the Venus foreshock

    International Nuclear Information System (INIS)

    Crawford, G.K.; Strangeway, R.J.; Russell, C.T.


    Plasma waves are observed in the solar wind upstream of the Venus bow shock by the Pioneer Venus Orbiter. These wave signatures occur during periods when the interplanetary magnetic field through the spacecraft position intersects the bow shock, thereby placing the spacecraft in the foreshock region. The electron foreshock boundary is clearly evident in the data as a sharp onset in wave activity and a peak in intensity. Wave intensity is seen to drop rapidly with increasing penetration into the foreshock. The peak wave electric field strength at the electron foreshock boundary is found to be similar to terrestrial observations. A normalized wave spectrum was constructed using measurements of the electron plasma frequency and the spectrum was found to be centered about this value. These results, along with polarization studies showing the wave electric field to be field aligned, are consistent with the interpretation of the waves as electron plasma oscillations

  14. Venus y el fin del mundo

    Directory of Open Access Journals (Sweden)

    Gonzalo Munévar


    Full Text Available Este artículo busca demostrar que los argumentos generales acerca de la exploración científica valen también para las ciencias espaciales. El trabajo se basa en el ejemplo de la exploración de Venus y lo que esta nos dice acerca de nuestro propio planeta. Argumenta que el concepto de la probabilidad de Leslie es incorrecto, como también lo son las dudas sobre la evidencia Venusiana. Así mismo, concluye que no se puede rechazar la importancia que tienen los descubrimientos inesperados que han resultado de la exploración de Venus para ayudarnos a comprender nuestro propio planeta. Y que si van a ser rechazados estos descubrimientos debe ser por razones científicas, no por intuiciones acerca de la probabilidad.

  15. Deuterium content of the Venus atmosphere

    International Nuclear Information System (INIS)

    Bertaux, -J.-L.; Clarke, J.T.


    The abundance of deuterium in the atmosphere of Venus is an important clue to the planet's history, because ordinary and deuterated water escape at different rates. Using the high-resolution mode of the International Ultraviolet Explorer (IUE), we measured hydrogen Lyman-α-emission but found only an upper limit on deuterium Lyman-α-emission, from which we inferred a D/H ratio of less than 2-5 x 10 -3 . This is smaller by a factor of 3-8 than the D/H ratio derived from measurements by the Pioneer Venus Large Probe, and may indicate either a stratification of D/H ratio with altitude or a smaller overall ratio than previously thought. (author)

  16. Unpolarized release of vaccinia virus and HIV antigen by colchicine treatment enhances intranasal HIV antigen expression and mucosal humoral responses.

    Directory of Open Access Journals (Sweden)

    Yan Zhang

    Full Text Available The induction of a strong mucosal immune response is essential to building successful HIV vaccines. Highly attenuated recombinant HIV vaccinia virus can be administered mucosally, but even high doses of immunization have been found unable to induce strong mucosal antibody responses. In order to solve this problem, we studied the interactions of recombinant HIV vaccinia virus Tiantan strain (rVTT-gagpol in mucosal epithelial cells (specifically Caco-2 cell layers and in BALB/c mice. We evaluated the impact of this virus on HIV antigen delivery and specific immune responses. The results demonstrated that rVTT-gagpol was able to infect Caco-2 cell layers and both the nasal and lung epithelia in BALB/c mice. The progeny viruses and expressed p24 were released mainly from apical surfaces. In BALB/c mice, the infection was limited to the respiratory system and was not observed in the blood. This showed that polarized distribution limited antigen delivery into the whole body and thus limited immune response. To see if this could be improved upon, we stimulated unpolarized budding of the virus and HIV antigens by treating both Caco-2 cells and BALB/c mice with colchicine. We found that, in BALB/c mice, the degree of infection and antigen expression in the epithelia went up. As a result, specific immune responses increased correspondingly. Together, these data suggest that polarized budding limits antigen delivery and immune responses, but unpolarized distribution can increase antigen expression and delivery and thus enhance specific immune responses. This conclusion can be used to optimize mucosal HIV vaccine strategies.

  17. VLF imaging of the Venus foreshock (United States)

    Crawford, G. K.; Strangeway, R. J.; Russell, C. T.


    VLF plasma wave measurements obtained from the Pioneer Venus Orbiter Electric Field Detector (OEFD) have been used to construct statistical images of the Venus foreshock. Our data set contains all upstream measurements from an entire Venus year (approximately 200 orbits). Since the foreshock VLF characteristics vary with Interplanetary Magnetic Field (IMF) orientation we restrict the study to IMF orientations near the nominal Parker spiral angle (25 to 45). Our results show a strong decrease in 30 kHz wave intensity with both foreshock depth and distance. There is also an asymmetry in the 30 kHz emissions from the upstream and downstream foreshocks. The ion foreshock is characterized by strong emissions in the 5.4 kHz OEFD channel which are positioned much deeper in the foreshock than expected from terrestrial observations. No activity is observed in the region where field aligned ion distributions are expected. ULF wave activity, while weaker than at Earth, shows similar behavior and may indicate the presence of similar ion distributions.

  18. Comparison of accelerated ion populations observed upstream of the bow shocks at Venus and Mars

    Directory of Open Access Journals (Sweden)

    M. Yamauchi


    Full Text Available Foreshock ions are compared between Venus and Mars at energies of 0.6~20 keV using the same ion instrument, the Ion Mass Analyser, on board both Venus Express and Mars Express. Venus Express often observes accelerated protons (2~6 times the solar wind energy that travel away from the Venus bow shock when the spacecraft location is magnetically connected to the bow shock. The observed ions have a large field-aligned velocity compared to the perpendicular velocity in the solar wind frame, and are similar to the field-aligned beams and intermediate gyrating component of the foreshock ions in the terrestrial upstream region. Mars Express does not observe similar foreshock ions as does Venus Express, indicating that the Martian foreshock does not possess the intermediate gyrating component in the upstream region on the dayside of the planet. Instead, two types of gyrating protons in the solar wind frame are observed very close to the Martian quasi-perpendicular bow shock within a proton gyroradius distance. The first type is observed only within the region which is about 400 km from the bow shock and flows tailward nearly along the bow shock with a similar velocity as the solar wind. The second type is observed up to about 700 km from the bow shock and has a bundled structure in the energy domain. A traversal on 12 July 2005, in which the energy-bunching came from bundling in the magnetic field direction, is further examined. The observed velocities of the latter population are consistent with multiple specular reflections of the solar wind at the bow shock, and the ions after the second reflection have a field-aligned velocity larger than that of the de Hoffman-Teller velocity frame, i.e., their guiding center has moved toward interplanetary space out from the bow shock. To account for the observed peculiarity of the Martian upstream region, finite gyroradius effects of the solar wind protons compared to the radius of the bow shock curvature and

  19. Dynamics of Venus' Southern hemisphere and South Polar Vortex from VIRTIS data obtained during the Venus Expres Mission (United States)

    Hueso, R.; Garate-Lopez, I.; Sanchez-Lavega, A.


    The VIRTIS instrument onboard Venus Express observes Venus in two channels (visible and infrared) obtaining spectra and multi-wavelength images of the planet. The images have been used to trace the motions of the atmosphere at different layers of clouds [1-3]. We review the VIRTIS cloud image data and wind results obtained by different groups [1-3] and we present new results concerning the morphology and evolution of the South Polar Vortex at the upper and lower cloud levels with data covering the first 900 days of the mission. We present wind measurements of the South hemisphere obtained by cloud tracking individual cloud features and higher-resolution wind results of the polar region covering the evolution of the South polar vortex. The later were obtained by an image correlation algorithm run under human supervision to validate the data. We present day-side data of the upper clouds obtained at 380 and 980 nm sensitive to altitudes of 66-70 km, night-side data in the near infrared at 1.74 microns of the lower cloud (45-50 km) and day and night-side data obtained in the thermal infrared (wavelengths of 3.8 and 5.1 microns) which covers the dynamical evolution of Venus South Polar vortex at the cloud tops (66-70 km). We explore the different dynamics associated to the varying morphology of the vortex, its dynamical structure at different altitudes, the variability of the global wind data of the southern hemisphere and the interrelation of the polar vortex dynamics with the wind dynamics at subpolar and mid-latitudes. Acknowledgements: Work funded by Spanish MICIIN AYA2009-10701 with FEDER support and Grupos Gobierno Vasco IT-464-07. References [1] A. Sánchez-Lavega et al., Geophys. Res. Lett. 35, L13204, (2008). [2] D. Luz et al., Science, 332, 577-580 (2011). [3] R. Hueso, et al., Icarus doi:10.1016/j.icarus.2011.04.020 (2011)

  20. Whole genome expression profiling associates activation of unfolded protein response with impaired production and release of epinephrine after recurrent hypoglycemia.

    Directory of Open Access Journals (Sweden)

    Juhye Lena Kim

    Full Text Available Recurrent hypoglycemia can occur as a major complication of insulin replacement therapy, limiting the long-term health benefits of intense glycemic control in type 1 and advanced type 2 diabetic patients. It impairs the normal counter-regulatory hormonal and behavioral responses to glucose deprivation, a phenomenon known as hypoglycemia associated autonomic failure (HAAF. The molecular mechanisms leading to defective counter-regulation are not completely understood. We hypothesized that both neuronal (excessive cholinergic signaling between the splanchnic nerve fibers and the adrenal medulla and humoral factors contribute to the impaired epinephrine production and release in HAAF. To gain further insight into the molecular mechanism(s mediating the blunted epinephrine responses following recurrent hypoglycemia, we utilized a global gene expression profiling approach. We characterized the transcriptomes during recurrent (defective counter-regulation model and acute hypoglycemia (normal counter-regulation group in the adrenal medulla of normal Sprague-Dawley rats. Based on comparison analysis of differentially expressed genes, a set of unique genes that are activated only at specific time points after recurrent hypoglycemia were revealed. A complementary bioinformatics analysis of the functional category, pathway, and integrated network indicated activation of the unfolded protein response. Furthermore, at least three additional pathways/interaction networks altered in the adrenal medulla following recurrent hypoglycemia were identified, which may contribute to the impaired epinephrine secretion in HAAF: greatly increased neuropeptide signaling (proenkephalin, neuropeptide Y, galanin; altered ion homeostasis (Na+, K+, Ca2+ and downregulation of genes involved in Ca2+-dependent exocytosis of secretory vesicles. Given the pleiotropic effects of the unfolded protein response in different organs, involved in maintaining glucose homeostasis, these

  1. Reassessment of planetary protection requirements for Venus missions (United States)

    Szostak, J.; Riemer, R.; Smith, D.; Rummel, J.

    In 2005 the US Space Studies Board SSB was asked by NASA to reexamine the planetary protection requirements for spacecraft missions to Venus In particular the SSB was tasked to 1 Assess the surface and atmospheric environments of Venus with respect to their ability to support the survival and growth of Earth-origin microbial contamination by future spacecraft missions and 2 Provide recommendations related to planetary protection issues associated with the return to Earth of samples from Venus The task group established by the SSB to address these issues assessed the known aspects of the present-day environment of Venus and the ability of Earth organisms to survive in the physical and chemical conditions found on the planet s surface or in the clouds in the planet s atmosphere As a result of its deliberations the task group found compelling evidence against there being significant dangers of forward or reverse biological contamination as a result of contact between a spacecraft and the surface of Venus or the clouds in the atmosphere of Venus regardless of the current unknowns The task group did however conclude that Venus is a body of interest relative to the process of chemical evolution and the origin of life As a result the task group endorses NASA s current policy of subjecting missions to Venus to the requirements imposed by planetary protection Category II rather than the less restrictive Category I recommended by COSPAR

  2. Chandra Captures Venus In A Whole New Light (United States)


    Scientists have captured the first X-ray view of Venus using NASA's Chandra X-ray Observatory. The observations provide new information about the atmosphere of Venus and open a new window for examining Earth's sister planet. Venus in X-rays looks similar to Venus in visible light, but there are important differences. The optically visible Venus is due to the reflection of sunlight and, for the relative positions of Venus, Earth and Sun during these observations, shows a uniform half-crescent that is brightest toward the middle. The X-ray Venus is slightly less than a half-crescent and brighter on the limbs. The differences are due to the processes by which Venus shines in visible and X-ray light. The X-rays from Venus are produced by fluorescence, rather than reflection. Solar X-rays bombard the atmosphere of Venus, knock electrons out of the inner parts of the atoms, and excite the atoms to a higher energy level. The atoms almost immediately return to their lower energy state with the emission of a fluorescent X-ray. A similar process involving ultraviolet light produces the visible light from fluorescent lamps. For Venus, most of the fluorescent X-rays come from oxygen and carbon atoms between 120 and 140 kilometers (74 to 87 miles) above the planet's surface. In contrast, the optical light is reflected from clouds at a height of 50 to 70 kilometers (31 to 43 miles). As a result, Venus' Sun-lit hemisphere appears surrounded by an almost-transparent luminous shell in X-rays. Venus looks brightest at the limb since more luminous material is there. Venus X-ray/Optical Composite of Venus Credit: Xray: NASA/CXC/MPE/K.Dennerl et al., Optical: Konrad Dennerl "This opens up the exciting possibility of using X-ray observations to study regions of the atmosphere of Venus that are difficult to investigate by other means," said Konrad Dennerl of the Max Planck Institute for Extraterrestrial Physics in Garching, Germany, leader of an international team of scientists that

  3. Volatile arsenic species released from Escherichia coli expressing the AsIII S-adenosylmethionine methyltransferase gene. (United States)

    Yuan, Chungang; Lu, Xiufen; Qin, Jie; Rosen, Barry P; Le, X Chris


    Biological systems, ranging from bacteria and fungi to humans, can methylate arsenic. Recent studies have suggested that the AsIII S-adenosylmethionine methyltransferase (arsM) gene in bacteria was responsible for the removal of arsenic as the volatile arsines from the bacteria. However, there has been no direct measure of the arsines released from bacteria cultures. We describe here an integrated system incorporating the bacterial incubation and volatile arsenic species analysis, and we demonstrate its application to the identification of the volatile arsines produced in bacterial cultures. The headspace of the bacterial cultures was purged with helium, and the volatile arsenic species were trapped in a chromatographic column immersed in liquid nitrogen. The cryogenically trapped arsines [AsH3, (CH3)AsH2, (CH3)2AsH, and (CH3)3As] were separated by gas chromatography and were detected by inductively coupled plasma mass spectrometry. A hydride generation system was coupled to the bacterial culture system, allowing for spiking standards and for generating calibration arsines necessary for quantitative analysis. Both bacteria containing the arsM gene or its variant arsMC2 gene were able to produce 400-500 ng of trimethylarsine. No trimethylarsine was detectable in bacteria lacking the arsM gene (containing the vector plasmid as negative control). These results confirm that arsM is responsible for releasing arsenic as volatile species from the arsenic-resistant bacteria. Our results also show traces of AsH3, CH3AsH2, and (CH3)2AsH in cultures of bacteria expressing arsM. The method detection limits for AsH3, CH3AsH2, (CH3)2AsH, and (CH3)3As were 0.5, 0.5, 0.7, and 0.6 pg, respectively. The ability to quantify trace levels of these volatile arsenic species makes it possible to study the biotransformation and biochemical roles of the evolution of these volatile arsenic species by biological systems.

  4. Venus gravity - Analysis of Beta Regio (United States)

    Esposito, P. B.; Sjogren, W. L.; Mottinger, N. A.; Bills, B. G.; Abbott, E.


    Radio tracking data acquired over Beta Regio were analyzed to obtain a surface mass distribution from which a detailed vertical gravity field was derived. In addition, a corresponding vertical gravity field was evaluated solely from the topography of the Beta region. A comparison of these two maps confirms the strong correlation between gravity and topography which was previously seen in line-of-sight gravity maps. It also demonstrates that the observed gravity is a significant fraction of that predicted from the topography alone. The effective depth of complete isostatic compensation for the Beta region is estimated to be 330 km, which is somewhat deeper than that found for other areas of Venus.

  5. Uvmas: Venus Ultraviolet-visual Mapping Spectrometer (United States)

    Bellucci, G.; Zasova, L.; Altieri, F.; Formisano, V.; Ignatiev, N.; Moroz, V.

    We present the concept of an instrument for remote sensing of Venus from a planetary orbiter. The main characteristics of the instrument are the following: A~é· Spectral range: 0.190 A~é­ 0.490 A~éµm A~é· Spectral resolution: 0.4 nm (/= 500 at 0.2 A~éµ m) A~é· Angular resolution: 0.4 mrad at max A~é· Spatial resolution: 200 meters at 500 Km A~é· Field of view = 5.7A~é° A~é· S/N: 70 at 0.2 A~éµ m at 1 sec exp time given albedo = 0.03. The scientific objectives are the following: Dynamic investigation (0.2 5 µm). Mapping facility will allow the tracking of the UV features and will define the velocities in the atmosphere near the cloud top level. Detailed mapping of velocities of UV features at high spatial resolution, their variation with latitude, altitude and local time will advance our knowledge in understanding the puzzles of Venus dynamics like how and what mechanism drives the Venus atmospheric mass from equator to pole against temperature gradient and what is the mechanism supporting the zonal superrotation. What is the polar vortex organization, at what latitudes there is the descending branch of the Hadley cell. SO2 and SO in the range 0.232 µm. In this spectral range the SO2 and SO bands are observed. They present unresolved features with 10 Å width. Vertical profiles of these components may be obtained above the cloud and below the upper cloud boundary. Vertical, horizontal, local time and temporal variation will be obtained. This allows to create a photochemical model of the atmosphere above the clouds, and to understand a mechanism of cloud aerosol formation. "Unknown" UV- absorber, in the range 0.3 5 µm. It absorbs 50 % of the solar energy deposited on Venus. It exists only in the upper clouds. It is not known if it is in gaseous phase or included in the aerosol particles. This absorber is not homogeneously distributed and is responsible for the UV atmospheric contrast from 0.32­0.5 µm; it correlates

  6. Long-term Behaviour Of Venus Winds At Cloud Level From Virtis/vex Observations (United States)

    Hueso, Ricardo; Peralta, J.; Sánchez-Lavega, A.; Pérez-Hoyos, S.; Piccioni, G.; Drossart, P.


    The Venus Express (VEX) mission has been in orbit to Venus for more than three years now. The VIRTIS instrument onboard VEX observes Venus in two channels (visible and infrared) obtaining spectra and multi-wavelength images of the planet. Images in the ultraviolet range are used to study the upper cloud at 66 km while images in the infrared (1.74 μm) map the opacity of the lower cloud deck at 48 km. Here we present an analysis of the overall dynamics of Venus’ atmosphere at both levels using observations that cover a large fraction of the VIRTIS dataset. We will present our latest results concerning the zonal winds, the overall stability in the lower cloud deck motions and the variability in the upper cloud. Meridional winds are also observed in the upper and lower cloud in the UV and IR images obtained with VIRTIS. While the upper clouds present a net meridional motion consistent with the upper branch of a Hadley cell the lower cloud present more irregular, variable and less intense motions in the meridional direction. Acknowledgements This work has been funded by Spanish MEC AYA2006-07735 with FEDER support and Grupos Gobierno Vasco IT-464-07. RH acknowledges a "Ramón y Cajal” contract from MEC.

  7. Evolution of a Coronal Mass Ejection from the Sun to Mercury, Venus, Earth and Beyond (United States)

    Wang, Y.; Shen, C.; Liu, J.; Mengjiao, X.; Guo, J.


    A clear magnetic cloud was observed by Messenger at Mercury. By using coronagraph images from SOHO/LASCO and STEREO/COR and the in-situ data from Wind near the Earth, we estimated its propgation velocity and identified the possible CME candidate in the corona and its counterpart recorded by Venus Express near Venus. By applying the CME's DIPS (Deflection in InterPlanetary Space) model, we show that the CME's arrivals at the three different heliocentric distance can be well reproduced. By extending the trajectory of the CME to the orbitor of Mars, we predict the arrival of the CME at Mars, which is in agreement with a significant Forbush decrease observed by MSL. We use uniformly-twisted force-free flux rope model to fit the in-situ measurements at Mercury, Venus and the Earth to study the evolution of the magnetic flux rope, and find that both axial magnetic flux and twist significantly decreased, suggesting that a significant erosion process was on-going and might change the averaged twist of the magnetic flux rope.

  8. Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone. (United States)

    Khadir, Abdelkrim; Kavalakatt, Sina; Abubaker, Jehad; Cherian, Preethi; Madhu, Dhanya; Al-Khairi, Irina; Abu-Farha, Mohamed; Warsame, Samia; Elkum, Naser; Dehbi, Mohammed; Tiss, Ali


    Perturbation of the endoplasmic reticulum (ER) homeostasis has emerged as one of the prominent features of obesity and diabetes. This occurs when the adaptive unfolded protein response (UPR) fails to restore ER function in key metabolic tissues. We previously reported increased inflammation and impaired heat shock response (HSR) in obese human subjects that were restored by physical exercise. Here, we investigated the status of ER stress chaperone; glucose-regulated protein 78 (GRP78) and its downstream UPR pathways in human obese, and their modulation by a supervised 3-month physical exercise. Subcutaneous adipose tissue (SAT) and blood samples were collected from non-diabetic adult human lean (n=40) and obese (n=40, at baseline and after 3months of physical exercise). Transcriptomic profiling was used as a primary screen to identify differentially expressed genes and it was carried out on SAT samples using the UPR RT(2) Profiler PCR Array. Conventional RT-PCR, immunohistochemistry, immunofluorescence, Western blot and ELISA were used to validate the transcriptomic data. Correlation analyses with the physical, clinical and biochemical outcomes were performed using Pearson's rank correlation coefficient. Levels of GRP78 and its three downstream UPR arms; activating transcription factor-6 (ATF6), inositol-requiring enzyme-1α (IRE1α) and protein kinase RNA-like endoplasmic reticulum kinase (PERK) were increased in obese subjects. More interestingly, higher levels of circulating GRP78 protein were found in obese compared to lean subjects which correlated negatively with maximum oxygen uptake (VO2 Max) but positively with high-sensitivity C-reactive protein (hsCRP) and obesity indicators such as BMI, percentage body fat (PBF) and waist circumference. GRP78 increased secretion in obese was further confirmed in vitro using 3T3-L1 preadipocyte cells under ER stress. Finally, we showed that physical exercise significantly attenuated the expression and release of GRP78

  9. Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis. (United States)

    Wallon, Conny; Persborn, Mats; Jönsson, Maria; Wang, Arthur; Phan, Van; Lampinen, Maria; Vicario, Maria; Santos, Javier; Sherman, Philip M; Carlson, Marie; Ericson, Ann-Charlott; McKay, Derek M; Söderholm, Johan D


    Altered intestinal barrier function has been implicated in the pathophysiology of ulcerative colitis (UC) in genetic, functional, and epidemiological studies. Mast cells and corticotropin-releasing factor (CRF) regulate the mucosal barrier in human colon. Because eosinophils are often increased in colon tissues of patients with UC, we assessed interactions among mast cells, CRF, and eosinophils in the mucosal barrier of these patients. Transmucosal fluxes of protein antigens (horseradish peroxidase) and paracellular markers ((51)Cr-EDTA, fluorescein isothiocyanate-dextran 4000) were studied in noninflamed, colonic mucosal biopsy samples collected from 26 patients with UC and 53 healthy volunteers (controls); samples were mounted in Ussing chambers. We also performed fluorescence and electron microscopy of human tissue samples, assessed isolated eosinophils, and performed mechanistic studies using in vitro cocultured eosinophils (15HL-60), mast cells (HMC-1), and a colonic epithelial cell line (T84). Colon tissues from patients with UC had significant increases in permeability to protein antigens compared with controls. Permeability was blocked by atropine (a muscarinic receptor antagonist), α-helical CRF(9-41) (a CRF receptor antagonist), and lodoxamide (a mast-cell stabilizer). Eosinophils were increased in number in UC tissues (compared with controls), expressed the most M2 and M3 muscarinic receptors of any mucosal cell type, and had immunoreactivity to CRF. In coculture studies, carbachol activation of eosinophils caused production of CRF and activation of mast cells, which increased permeability of T84 epithelial cells to macromolecules. We identified a neuroimmune intercellular circuit (from cholinergic nerves, via eosinophils to mast cells) that mediates colonic mucosal barrier dysfunction in patients with UC. This circuit might exacerbate mucosal inflammation. Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.

  10. Chronic stress induces sex-specific alterations in methylation and expression of corticotropin-releasing factor gene in the rat.

    Directory of Open Access Journals (Sweden)

    Linda Sterrenburg

    Full Text Available BACKGROUND: Although the higher prevalence of depression in women than in men is well known, the neuronal basis of this sex difference is largely elusive. METHODS: Male and female rats were exposed to chronic variable mild stress (CVMS after which immediate early gene products, corticotropin-releasing factor (CRF mRNA and peptide, various epigenetic-associated enzymes and DNA methylation of the Crf gene were determined in the hypothalamic paraventricular nucleus (PVN, oval (BSTov and fusiform (BSTfu parts of the bed nucleus of the stria terminalis, and central amygdala (CeA. RESULTS: CVMS induced site-specific changes in Crf gene methylation in all brain centers studied in female rats and in the male BST and CeA, whereas the histone acetyltransferase, CREB-binding protein was increased in the female BST and the histone-deacetylase-5 decreased in the male CeA. These changes were accompanied by an increased amount of c-Fos in the PVN, BSTfu and CeA in males, and of FosB in the PVN of both sexes and in the male BSTov and BSTfu. In the PVN, CVMS increased CRF mRNA in males and CRF peptide decreased in females. CONCLUSIONS: The data confirm our hypothesis that chronic stress affects gene expression and CRF transcriptional, translational and secretory activities in the PVN, BSTov, BSTfu and CeA, in a brain center-specific and sex-specific manner. Brain region-specific and sex-specific changes in epigenetic activity and neuronal activation may play, too, an important role in the sex specificity of the stress response and the susceptibility to depression.

  11. Transit of Venus Culture: A Celestial Phenomenon Intrigues the Public (United States)

    Bueter, Chuck


    When Jeremiah Horrocks first observed it in 1639, the transit of Venus was a desirable telescopic target because of its scientific value. By the next transit of Venus in 1761, though, the enlightened public also embraced it as a popular celestial phenomenon. Its stature elevated over the centuries, the transit of Venus has been featured in music, poetry, stamps, plays, books, and art. The June 2004 transit emerged as a surprising global sensation, as suggested by the search queries it generated. Google's Zeitgeist deemed Venus Transit to be the #1 Most Popular Event in the world for that month. New priorities, technologies, and media have brought new audiences to the rare alignment. As the 2012 transit of Venus approaches, the trend continues with publicly accessible capabilities that did not exist only eight years prior. For example, sites from which historic observations have been made are plotted and readily available on Google Earth. A transit of Venus phone app in development will, if fully funded, facilitate a global effort to recreate historic expeditions by allowing smartphone users to submit their observed transit timings to a database for quantifying the Astronomical Unit. While maintaining relevance in modern scientific applications, the transit of Venus has emerged as a cultural attraction that briefly intrigues the mainstream public and inspires their active participation in the spectacle.


    International Nuclear Information System (INIS)

    Pasachoff, Jay M.; Schneider, Glenn; Widemann, Thomas


    This paper presents the only space-borne optical-imaging observations of the 2004 June 8 transit of Venus, the first such transit visible from Earth since AD 1882. The high-resolution, high-cadence satellite images we arranged from NASA's Transition Region and Coronal Explorer (TRACE) reveal the onset of visibility of Venus's atmosphere and give further information about the black-drop effect, whose causes we previously demonstrated from TRACE observations of a transit of Mercury. The atmosphere is gradually revealed before second contact and after third contact, resulting from the changing depth of atmospheric layers refracting the photospheric surface into the observer's direction. We use Venus Express observations to relate the atmospheric arcs seen during the transit to the atmospheric structure of Venus. Finally, we relate the transit images to current and future exoplanet observations, providing a sort of ground truth showing an analog in our solar system to effects observable only with light curves in other solar systems with the Kepler and CoRoT missions and ground-based exoplanet-transit observations.

  13. Improved automatic estimation of winds at the cloud top of Venus using superposition of cross-correlation surfaces (United States)

    Ikegawa, Shinichi; Horinouchi, Takeshi


    Accurate wind observation is a key to study atmospheric dynamics. A new automated cloud tracking method for the dayside of Venus is proposed and evaluated by using the ultraviolet images obtained by the Venus Monitoring Camera onboard the Venus Express orbiter. It uses multiple images obtained successively over a few hours. Cross-correlations are computed from the pair combinations of the images and are superposed to identify cloud advection. It is shown that the superposition improves the accuracy of velocity estimation and significantly reduces false pattern matches that cause large errors. Two methods to evaluate the accuracy of each of the obtained cloud motion vectors are proposed. One relies on the confidence bounds of cross-correlation with consideration of anisotropic cloud morphology. The other relies on the comparison of two independent estimations obtained by separating the successive images into two groups. The two evaluations can be combined to screen the results. It is shown that the accuracy of the screened vectors are very high to the equatorward of 30 degree, while it is relatively low at higher latitudes. Analysis of them supports the previously reported existence of day-to-day large-scale variability at the cloud deck of Venus, and it further suggests smaller-scale features. The product of this study is expected to advance the dynamics of venusian atmosphere.

  14. Corona Associations and Their Implications for Venus (United States)

    Chapman, M.G.; Zimbelman, J.R.


    Geologic mapping principles were applied to determine genetic relations between coronae and surrounding geomorphologic features within two study areas in order to better understand venusian coronae. The study areas contain coronae in a cluster versus a contrasting chain and are (1) directly west of Phoebe Regio (quadrangle V-40; centered at latitude 15??S, longitude 250??) and (2) west of Asteria and Beta Regiones (between latitude 23??N, longitude 239?? and latitude 43??N, longitude 275??). Results of this research indicate two groups of coronae on Venus: (1) those that are older and nearly coeval with regional plains, and occur globally; and (2) those that are younger and occur between Beta, Atla, and Themis Regiones or along extensional rifts elsewhere, sometimes showing systematic age progressions. Mapping relations and Earth analogs suggest that older plains coronae may be related to a near-global resurfacing event perhaps initiated by a mantle superplume or plumes. Younger coronae of this study that show age progression may be related to (1) a tectonic junction of connecting rifts resulting from local mantle upwelling and spread of a quasi-stationary hotspot plume, and (2) localized spread of post-plains volcanism. We postulate that on Venus most of the young, post-resurfacing coronal plumes may be concentrated within an area defined by the bounds of Beta, Atla, and Themis Regiones. ?? 1998 Academic Press.

  15. The Venus flybys opportunity with BEPICOLOMBO (United States)

    Mangano, Valeria; de la Fuente, Sara; Montagnon, Elsa; Benkhoff, Johannes; Zender, Joe; Orsini, Stefano


    BepiColombo is a dual spacecraft mission to Mercury to be launched in October 2018 and carried out jointly between the European Space Agency (ESA) and the Japanese Aerospace Exploration Agency (JAXA). The Mercury Planetary Orbiter (MPO) payload comprises eleven experiments and instrument suites. It will focus on a global characterization of Mercury through the investigation of its interior, surface, exosphere and magnetosphere. In addition, it will test Einstein's theory of general relativity. The second spacecraft, the Mercury Magnetosphere Orbiter (MMO), will carry five experiments or instrument suites to study the environment around the planet including the planet's exosphere and magnetosphere, and their interaction processes with the solar wind. The composite spacecraft made of MPO, MMO, a transfer module (MTM) and a sunshield (MOSIF) will be launched on an escape trajectory that will bring it into heliocentric orbit on its way to Mercury. During the cruise of 7.2 years toward the inner part of the Solar System, BepiColombo will make 1 flyby to the Earth, 2 to Venus, and 6 to Mercury. Only part of its payload will be obstructed by the sunshield and the cruise spacecraft configuration, so that the two flybys to Venus will allow operations of many instruments, like: spectrometers at many wavelengths, accelerometer, radiometer, ion and electron detectors. A scientific working group has recently formed from the BepiColombo community to identify potentially interesting scientific cases and to analyse operation timelines. Preliminary outputs will be presented and discussed.

  16. VLF emissions in the Venus foreshock - Comparison with terrestrial observations (United States)

    Crawford, G. K.; Strangeway, R. J.; Russell, C. T.


    An examination is conducted of ELF/VLF emissions observed in the solar wind upstream of the Venus shock, for the 100 Hz-30 kHz range, using data from the Pioneer Venus Orbiter's electric field detector and magnetometer instruments. Detailed comparisons are made with terrestrial measurements for both the electron and ion foreshocks. The results obtained support the Crawford et al. (1990) identification of the Venus electron foreshock emissions as electron plasma oscillations, whose waves are generated in situ and act to isotropize the electron distributions.

  17. Pioneer Venus and near-earth observations of interplanetary shocks

    International Nuclear Information System (INIS)

    Mihalov, J.D.; Russell, C.T.; Knudsen, W.C.; Scarf, F.L.


    Twenty-three transient interplanetary shocks observed near earth during 1978-1982, and mostly reported in the literature, have also been identified at the Pioneer Venus Orbiter spacecraft. There seems to be a fairly consistent trend for lower shock speeds, farther from the sun. Shock normals obtained using the Pioneer Venus data correspond well with published values from near earth. By referring to the portion of the Pioneer Venus plasma data used here from locations at longitudes within 37 degree of earth, it is found that shocks are weaker at earth, compared with closer to the sun

  18. Geology of the Venus equatorial region from Pioneer Venus radar imaging

    International Nuclear Information System (INIS)

    Senske, D.A.; Head, J.W.


    The surface characteristics and morphology of the equatorial region of Venus were first described by Masursky et al. who showed this part of the planet to be characterized by two topographic provinces, rolling plains and highlands, and more recently by Schaber who described and interpreted tectonic zones in the highlands. Using Pioneer Venus (PV) radar image data (15 deg S to 45 deg N), Senske and Head examined the distribution, characteristics, and deposits of individual volcanic features in the equatorial region, and in addition classified major equatorial physiographic and tectonic units on the basis of morphology, topographic signature, and radar properties derived from the PV data. Included in this classification are: plains (undivided), inter-highland tectonic zones, tectonically segmented linear highlands, upland rises, tectonic junctions, dark halo plains, and upland plateaus. In addition to the physiographic units, features interpreted as coronae and volcanic mountains have also been mapped. The latter four of the physiographic units along with features interpreted to be coronae

  19. Adenoviral vectors for highly selective gene expression in central serotonergic neurons reveal quantal characteristics of serotonin release in the rat brain

    Directory of Open Access Journals (Sweden)

    Teschemacher Anja G


    Full Text Available Abstract Background 5-hydroxytryptamine (5 HT, serotonin is one of the key neuromodulators in mammalian brain, but many fundamental properties of serotonergic neurones and 5 HT release remain unknown. The objective of this study was to generate an adenoviral vector system for selective targeting of serotonergic neurones and apply it to study quantal characteristics of 5 HT release in the rat brain. Results We have generated adenoviral vectors which incorporate a 3.6 kb fragment of the rat tryptophan hydroxylase-2 (TPH-2 gene which selectively (97% co-localisation with TPH-2 target raphe serotonergic neurones. In order to enhance the level of expression a two-step transcriptional amplification strategy was employed. This allowed direct visualization of serotonergic neurones by EGFP fluorescence. Using these vectors we have performed initial characterization of EGFP-expressing serotonergic neurones in rat organotypic brain slice cultures. Fluorescent serotonergic neurones were identified and studied using patch clamp and confocal Ca2+ imaging and had features consistent with those previously reported using post-hoc identification approaches. Fine processes of serotonergic neurones could also be visualized in un-fixed tissue and morphometric analysis suggested two putative types of axonal varicosities. We used micro-amperometry to analyse the quantal characteristics of 5 HT release and found that central 5 HT exocytosis occurs predominantly in quanta of ~28000 molecules from varicosities and ~34000 molecules from cell bodies. In addition, in somata, we observed a minority of large release events discharging on average ~800000 molecules. Conclusion For the first time quantal release of 5 HT from somato-dendritic compartments and axonal varicosities in mammalian brain has been demonstrated directly and characterised. Release from somato-dendritic and axonal compartments might have different physiological functions. Novel vectors generated in this

  20. Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse

    Directory of Open Access Journals (Sweden)

    Guy eMalkinson


    Full Text Available Much of what we know about the mechanisms underlying Homosynaptic Depression (HSD and heterosynaptic facilitation is based on intracellular recordings of integrated postsynaptic potentials. This methodological approach views the presynaptic apparatus as a single compartment rather than taking a more realistic representation reflecting the fact that it is made up of tens to hundreds of individual and independent Presynaptic Release Boutons (PRBs. Using cultured Aplysia sensorimotor synapses, we reexamined HSD and its dishabituation by imaging the release properties of individual PRBs. We find that the PRB population is heterogeneous and can be clustered into three groups: approximately 25% of the PRBs consistently release neurotransmitter throughout the entire habituation paradigm (35 stimuli, 0.05Hz and have a relatively high quantal content, 36% of the PRBs display intermittent failures only after the tenth stimulation, and 39% are low quantal-content PRBs that exhibit intermittent release failures from the onset of the habituation paradigm. 5HT-induced synaptic dishabituation by a single 5HT application was generated by the enhanced recovery of the quantal content of the habituated PRBs and did not involve the recruitment of new release boutons. The characterization of the PRB population as heterogeneous in terms of its temporal pattern of release-probability and quantal content provides new insights into the mechanisms underlying HSD and its dishabituation.

  1. Spinal neurons that contain gastrin-releasing peptide seldom express Fos or phosphorylate extracellular signal-regulated kinases in response to intradermal chloroquine


    Bell, Andrew M; Gutierrez-Mecinas, Maria; Polg?r, Erika; Todd, Andrew J


    Background: Gastrin-releasing peptide (GRP) is thought to play a role in the itch evoked by intradermal injection of chloroquine. Although some early studies suggested that GRP was expressed in pruriceptive primary afferents, it is now thought that GRP in the spinal cord is derived mainly from a population of excitatory interneurons in lamina II, and it has been suggested that these are involved in the itch pathway. To test this hypothesis, we used the transcription factor Fos and phosphoryla...

  2. Low-dose Norfloxacin-treated leptospires induce less IL-1β release in J774A.1 cells following discrepant leptospiral gene expression. (United States)

    Cao, Yongguo; Xie, Xufeng; Zhang, Wenlong; Wu, Dianjun; Tu, Changchun


    Currently, accumulating evidence is challenging subtherapeutic therapy. Low-dose Norfloxacin (Nor) has been reported to suppress the immune response and worsen leptospirosis. In this study, we investigated the influence of low-dose Nor (0.03 μg/ml, 0.06 μg/ml, 0.125 μg/ml) on leptospiral gene expression and analyzed the immunomodulatory effects of low-dose Nor-treated leptospires in J774A.1 cells. To study the expression profiles of low-dose Nor-treated leptospires, we chose LipL71/LipL21 as reference genes determined by the geNorm applet in this experiment. The results showed that low-dose Nor up-regulated the expression of FlaB and inhibited the expression of 16S rRNA, LipL32, LipL41, Loa22, KdpA, and KdpB compared with the untreated leptospires. These results indicated that low-dose Nor could regulate leptospiral gene expression. Using RT-PCR, the gene expression of IL-1β and TNF-α in J774A.1 cells was detected. Nor-treated leptospires induced higher expression levels of both IL-1β and TNF-α. However, when analyzed by ELISA, the release of mature IL-1β was reduced compared with that observed in cells induced with no Nor-treated leptospires, although the TNF-α protein level showed no significant change. Our study indicated that the gene expression of leptospires could be modulated by low-dose Nor, which induced less IL-1β release in J774A.1 cells. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Volcano morphometry and volume scaling on Venus (United States)

    Garvin, J. B.; Williams, R. S., Jr.


    A broad variety of volcanic edifices have been observed on Venus. They ranged in size from the limits of resolution of the Magellan SAR (i.e., hundreds of meters) to landforms over 500 km in basal diameter. One of the key questions pertaining to volcanism on Venus concerns the volume eruption rate or VER, which is linked to crustal productivity over time. While less than 3 percent of the surface area of Venus is manifested as discrete edifices larger than 50 km in diameter, a substantial component of the total crustal volume of the planet over the past 0.5 Ga is related to isolated volcanoes, which are certainly more easily studied than the relatively diffusely defined plains volcanic flow units. Thus, we have focused our efforts on constraining the volume productivity of major volcanic edifices larger than 100 km in basal diameter. Our approach takes advantage of the topographic data returned by Magellan, as well as our database of morphometric statistics for the 20 best known lava shields of Iceland, plus Mauna Loa of Hawaii. As part of this investigation, we have quantified the detailed morphometry of nearly 50 intermediate to large scale edifices, with particular attention to their shape systematics. We found that a set of venusian edifices which include Maat, Sapas, Tepev, Sif, Gula, a feature at 46 deg S, 215 deg E, as well as the shield-like structure at 10 deg N, 275 deg E are broadly representative of the approx. 400 volcanic landforms larger than 50 km. The cross-sectional shapes of these 7 representative edifices range from flattened cones (i.e., Sif) similar to classic terrestrial lava shields such as Mauna Loa and Skjaldbreidur, to rather dome-like structures which include Maat and Sapas. The majority of these larger volcanoes surveyed as part of our study displayed cross-sectional topographies with paraboloidal shaped, in sharp contrast with the cone-like appearance of most simple terrestrial lava shields. In order to more fully explore the

  4. Exploration of Venus' Deep Atmosphere and Surface Environment (United States)

    Glaze, L. S.; Amato, M.; Garvin, J. B.; Johnson, N. M.


    Venus formed in the same part of our solar system as Earth, apparently from similar materials. Although both planets are about the same size, their differences are profound. Venus and Earth experienced vastly different evolutionary pathways resulting in unexplained differences in atmospheric composition and dynamics, as well as in geophysical processes of the planetary surfaces and interiors. Understanding when and why the evolutionary pathways of Venus and Earth diverged is key to understanding how terrestrial planets form and how their atmospheres and surfaces evolve. Measurements made in situ, within the near-surface or surface environment, are critical to addressing unanswered questions. We have made substantial progress modernizing and maturing pressure vessel technologies to enable science operations in the high temperature and pressure near-surface/surfaceenvironment of Venus.

  5. Earth-type planets (Mercury, Venus, and Mars) (United States)

    Marov, M. Y.; Davydov, V. D.


    Spacecraft- and Earth-based studies on the physical nature of the planets Mercury, Venus, and Mars are reported. Charts and graphs are presented on planetary surface properties, rotational parameters, atmospheric compositions, and astronomical characteristics.

  6. Engineers are from Mars and educators are from Venus: Research ...

    African Journals Online (AJOL)

    ... are from Venus: Research supervision in engineering and educational collaboration. ... The projects usually entailed an interdisciplinary thesis that addressed an ... in chemical engineering, the work-readiness of civil engineering students, ...

  7. Venus' night side atmospheric dynamics using near infrared observations from VEx/VIRTIS and TNG/NICS (United States)

    Mota Machado, Pedro; Peralta, Javier; Luz, David; Gonçalves, Ruben; Widemann, Thomas; Oliveira, Joana


    We present night side Venus' winds based on coordinated observations carried out with Venus Express' VIRTIS instrument and the Near Infrared Camera (NICS) of the Telescopio Nazionale Galileo (TNG). With NICS camera, we acquired images of the continuum K filter at 2.28 μm, which allows to monitor motions at the Venus' lower cloud level, close to 48 km altitude. We will present final results of cloud tracked winds from ground-based TNG observations and from coordinated space-based VEx/VIRTIS observations.The Venus' lower cloud deck is centred at 48 km of altitude, where fundamental dynamical exchanges that help maintain superrotation are thought to occur. The lower Venusian atmosphere is a strong source of thermal radiation, with the gaseous CO2 component allowing radiation to escape in windows at 1.74 and 2.28 μm. At these wavelengths radiation originates below 35 km and unit opacity is reached at the lower cloud level, close to 48 km. Therefore, it is possible to observe the horizontal cloud structure, with thicker clouds seen silhouetted against the bright thermal background from the low atmosphere. By continuous monitoring of the horizontal cloud structure at 2.28 μm (NICS Kcont filter), it is possible to determine wind fields using the technique of cloud tracking. We acquired a series of short exposures of the Venus disk. Cloud displacements in the night side of Venus were computed taking advantage of a phase correlation semi-automated technique. The Venus apparent diameter at observational dates was greater than 32" allowing a high spatial precision. The 0.13" pixel scale of the NICS narrow field camera allowed to resolve ~3-pixel displacements. The absolute spatial resolution on the disk was ~100 km/px at disk center, and the (0.8-1") seeing-limited resolution was ~400 km/px. By co-adding the best images and cross-correlating regions of clouds the effective resolution was significantly better than the seeing-limited resolution. In order to correct for

  8. Venus surface peeking through the atmosphere - gaining a global perspective on the surface composition through near infrared observations (United States)

    Helbert, J.; Dyar, M. D.; Maturilli, A.; D'Amore, M.; Ferrari, S.; Mueller, N. T.; Smrekar, S. E.


    Venus is the most Earth-like of the terrestrial planets, though very little is known about its surface composition. Thanks to recent advances in laboratory spectroscopy and spectral analysis techniques, this is about to change. Although the atmosphere prohibits observations of the surface with traditional imaging techniques over much of the EM spectral range, five transparent windows between 0.86 µm and 1.18 µm occur in the atmosphere's CO2 spectrum. New high temperature laboratory spectra from the Planetary Spectroscopy Laboratory at DLR show that spectra in these windows are highly diagnostic for surface mineralogy [1]. The Venus Emissivity Mapper (VEM) [2] builds on these recent advances. It is proposed for NASA's Venus Origins Explorer where a radar will provided the needed high-resolution altimetry and ESA's EnVision would provide stereo topography instead. VEM is the first flight instrument specially designed to focus solely on mapping Venus' surface using the windows around 1 µm. Operating in situ from Venus orbit, VEM will provide a global map of composition as well as redox state of the surface, enabling a comprehensive picture of surface-atmosphere interaction on Venus. VEM will return a complex data set containing surface, atmospheric, cloud, and scattering information. Total planned data volume for a typical mission scenario exceeds 1TB. Classical analysis techniques have been successfully used for VIRTIS on Venus Express [3-5] and could be employed with the VEM data. However, application of machine learning approaches to this rich dataset is vastly more efficient, as has already been confirmed with laboratory data. Binary classifiers [6] demonstrate that at current best estimate errors, basalt spectra are confidently discriminated from basaltic andesites, andesites, and rhyolite/granite. Applying the approach of self-organizing maps to the increasingly large set of laboratory measurements allows searching for additional mineralogical indicators

  9. The multistring model VENUS for ultrarelativistic heavy ion collisions

    International Nuclear Information System (INIS)

    Werner, K.


    The event generator VENUS is based on a multistring model for heavy ion collisions at ultrarelativistic energies. The model is a straightforward extension of a successful model for soft proton-proton scattering, the latter one being consistent with e/sup /plus//e/sup /minus// annihilation and deep inelastic lepton scattering. Comparisons of VENUS results with pA and recent AA data alow some statements about intranuclear cascading. 18 refs., 7 figs

  10. The Venus Emissivity Mapper - Investigating the Atmospheric Structure and Dynamics of Venus' Polar Region (United States)

    Widemann, T.; Marcq, E.; Tsang, C.; Mueller, N. T.; Kappel, D.; Helbert, J.; Dyar, M. D.; Smrekar, S. E.


    Venus' climate evolution is driven by the energy balance of its global cloud layers. Venus displays the best-known case of polar vortices evolving in a fast-rotating atmosphere. Polar vortices are pervasive in the Solar System and may also be present in atmosphere-bearing exoplanets. While much progress has been made since the early suggestion that the Venus clouds are H2O-H2SO4 liquid droplets (Young 1973), several cloud parameters are still poorly constrained, particularly in the lower cloud layer and optically thicker polar regions. The average particle size is constant over most of the planet but increases toward the poles. This indicates that cloud formation processes are different at latitudes greater than 60°, possibly as a result of the different dynamical regimes that exist in the polar vortices (Carlson et al. 1993, Wilson et al. 2008, Barstow et al. 2012). Few wind measurements exist in the polar region due to unfavorable viewing geometry of currently available observations. Cloud-tracking data indicate circumpolar circulation close to solid-body rotation. E-W winds decrease to zero velocity close to the pole. N-S circulation is marginal, with extremely variable morphology and complex vorticity patterns (Sanchez-Lavega et al. 2008, Luz et al. 2011, Garate-Lopez et al. 2013). The Venus Emissivity Mapper (VEM; Helbert et al., 2016) proposed for NASA's Venus Origins Explorer (VOX) and the ESA M5/EnVision orbiters has the capability to better constrain the microphysics (vertical, horizontal, time dependence of particle size distribution, or/and composition) of the lower cloud particles in three spectral bands at 1.195, 1.310 and 1.510 μm at a spatial resolution of 10 km. Circular polar orbit geometry would provide an unprecedented study of both polar regions within the same mission. In addition, VEM's pushbroom method will allow short timescale cloud dynamics to be assessed, as well as local wind speeds, using repeated imagery at 90 minute intervals

  11. Macrophage migration inhibitory factor counter-regulates dexamethasone-induced annexin 1 expression and influences the release of eicosanoids in murine macrophages. (United States)

    Sun, Yu; Wang, Yu; Li, Jia-Hui; Zhu, Shi-Hui; Tang, Hong-Tai; Xia, Zhao-Fan


    Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine and glucocorticoid (GC) counter-regulator, has emerged as an important modulator of inflammatory responses. However, the molecular mechanisms of MIF counter-regulation of GC still remain incomplete. In the present study, we investigated whether MIF mediated the counter-regulation of the anti-inflammatory effect of GC by affecting annexin 1 in RAW 264.7 macrophages. We found that stimulation of RAW 264.7 macrophages with lipopolysaccharide (LPS) resulted in down-regulation of annexin 1, while GC dexamethasone (Dex) or Dex plus LPS led to significant up-regulation of annexin 1 expression. RNA interference-mediated knockdown of intracellular MIF increased annexin 1 expression with or without incubation of Dex, whereas Dex-induced annexin 1 expression was counter-regulated by the exogenous application of recombinant MIF. Moreover, recombinant MIF counter-regulated, in a dose-dependent manner, inhibition of cytosolic phospholipase A2α (cPLA2α) activation and prostaglandin E2 (PGE2 ) and leukotriene B4 (LTB4 ) release by Dex in RAW 264.7 macrophages stimulated with LPS. Endogenous depletion of MIF enhanced the effects of Dex, reflected by further decease of cPLA2α expression and lower PGE2 and LTB4 release in RAW 264.7 macrophages. Based on these data, we suggest that MIF counter-regulates Dex-induced annexin 1 expression, further influencing the activation of cPLA2α and the release of eicosanoids. These findings will add new insights into the mechanisms of MIF counter-regulation of GC. © 2013 John Wiley & Sons Ltd.

  12. Analysis of the VENUS-3 experiments

    International Nuclear Information System (INIS)

    Maerker, R.E.; D'hondt, P.; Leenders, L.; Fabry, A.


    The results of applying a hybrid superposition-synthesis calculational method to a mockup of a three-dimensional geometry involving a partial length shield assembly at the VENUS-3 facility in Mol, Belgium, are described. Comparisons of transport calculations using the method and many measurements involving nickel, indium, and aluminum dosimeters indicate agreement usually to within measurement uncertainties estimated at around 5%, if effects of inaccuracies in the dosimeter cross sections are minimized and proper orientation of the coordinate system used in the synthesis procedure is observed. These conclusions suggest a solution to the problem of predicting pressure vessel fluence in reactors modified by these partial-length shield assemblies may already exist. 7 refs., 2 figs., 1 tab

  13. Nuclear instrumentation in VENUS-F (United States)

    Wagemans, J.; Borms, L.; Kochetkov, A.; Krása, A.; Van Grieken, C.; Vittiglio, G.


    VENUS-F is a fast zero power reactor with 30 wt% U fuel and Pb/Bi as a coolant simulator. Depending on the experimental configuration, various neutron spectra (fast, epithermal, and thermal islands) are present. This paper gives a review of the nuclear instrumentation that is applied for reactor control and in a large variety of physics experiments. Activation foils and fission chambers are used to measure spatial neutron flux profiles, spectrum indices, reactivity effects (with positive period and compensation method or the MSM method) and kinetic parameters (with the Rossi-alpha method). Fission chamber calibrations are performed in the standard irradiation fields of the BR1 reactor (prompt fission neutron spectrum and Maxwellian thermal neutron spectrum).

  14. Lightning measurements from the Pioneer Venus Orbiter (United States)

    Scarf, F. L.; Russell, C. T.


    The plasma wave instrument on the Pioneer Venus Orbiter frequently detects strong and impulsive low-frequency signals when the spacecraft traverses the nightside ionosphere near periapsis. These particular noise bursts appear only when the local magnetic field is strong and steady and when the field is oriented to point down to the ionosphere thus; the signals have all characteristics of lightning whistlers. We have tried to identify lightning sources between the cloud layers and the planet itself by tracing rays along the B-field from the Orbiter down toward the surface. An extensive data set, consisting of measurements through Orbit 1185, strongly indicates a clustering of lightning sources near the Beta and Phoebe Regios, with an additional significant cluster near the Atla Regio at the eastern edge of Aphrodite Terra. These results suggest that there are localized lightning sources at or near the planetary surface.

  15. Venus - Volcanic features in Atla Region (United States)


    This Magellan image from the Atla region of Venus shows several types of volcanic features and superimposed surface fractures. The area in the image is approximately 350 kilometers (217 miles) across, centered at 9 degrees south latitude, 199 degrees east longitude. Lava flows emanating from circular pits or linear fissures form flower-shaped patterns in several areas. A collapse depression approximately 20 kilometers by 10 kilometers (12 by 6 miles) near the center of the image is drained by a lava channel approximately 40 kilometers (25 miles) long. Numerous surface fractures and graben (linear valleys) criss-cross the volcanic deposits in north to northeast trends. The fractures are not buried by the lavas, indicating that the tectonic activity post-dates most of the volcanic activity.

  16. Venus radar mapper attitude reference quaternion (United States)

    Lyons, D. T.


    Polynomial functions of time are used to specify the components of the quaternion which represents the nominal attitude of the Venus Radar mapper spacecraft during mapping. The following constraints must be satisfied in order to obtain acceptable synthetic array radar data: the nominal attitude function must have a large dynamic range, the sensor orientation must be known very accurately, the attitude reference function must use as little memory as possible, and the spacecraft must operate autonomously. Fitting polynomials to the components of the desired quaternion function is a straightforward method for providing a very dynamic nominal attitude using a minimum amount of on-board computer resources. Although the attitude from the polynomials may not be exactly the one requested by the radar designers, the polynomial coefficients are known, so they do not contribute to the attitude uncertainty. Frequent coefficient updates are not required, so the spacecraft can operate autonomously.

  17. An Encounter between the Sun and Venus

    CERN Multimedia


    The astronomical event of the year will take place on Tuesday, 8 June, when Venus transits across the disk of the sun. In the framework of CERN's 50th anniversary celebrations, the CERN Astronomy Club and the Orion Club invite you to attend their observation of the event on the car park of the Val-Thoiry shopping centre (France) between 7.15 a.m. and 1.30 p.m. Various instruments will be set up in a special tent so that the event can be observed without any risk of damage to the eyes. As the observation of this astronomical event will depend on the weather forecast, confirmation of the above arrangements will be given on the 50th anniversary website the day before.

  18. The Reappearance of Venus Observed 8 October 2015 (United States)

    Dunham, David W.; Dunham, Joan B.


    The reappearance of Venus on October 8, 2015 offered a unique opportunity to attempt observation of the ashen light of Venus as the unlit side of Venus emerged from behind the dark side of the Moon. The dark side of Venus would be offered to observers without interference from the bright side of Venus or of the Moon. Observations were made from Alice Springs, Australia visually with a 20-cm Schmidt-Cassegrain and with a low-light level surveillance camera on a 25-cm reflector. No evidence of the dark side was noted by the visual observer, the video shows little indication of Venus prior to the bright side reappearance. The conclusion reached is that the ashen light, as it was classically defined, is not observable visually or with small telescopes in the visual regime.The presentation describes the prediction, observation technique, and various analyses by the authors and others to draw conclusions from the data.To date, the authors have been unable to locate any reports of others attempting to observe this unique event. That is a pity since, not only was it interesting for an attempt to verify past observations of the ashen light, it was also a visually stunning event.

  19. Surface age of venus: use of the terrestrial cratering record

    International Nuclear Information System (INIS)

    Schaber, G.G.; Shoemaker, E.M.; Kozak, R.C.


    The average crater age of Venus' northern hemisphere may be less than 250 m.y. assuming equivalence between the recent terrestrial cratering rate and that on Venus for craters ≥ 20 km in diameter. For craters larger than this threshold size, below which crater production is significantly affected by the Venusian atmosphere, there are fairly strong observational grounds for concluding that such an equivalence in cratering rates on Venus and Earth may exist. However, given the uncertainties in the role of both active and inactive comet nuclei in the cratering history of Earth, we conclude that the age of the observed surface in the northern hemisphere of Venus could be as great as the 450-m.y. mean age of the Earth's crust. The observed surface of Venus might be even older, but no evidence from the crater observations supports an age as great as 1 b.y. If the age of the observed Venusian surface were 1 b.y., it probably should bear the impact scars of a half dozen or more large comet nuclei that penetrated the atmosphere and formed craters well over 100 km in diameter. Venera 15/16 mapped only about 25% of Venus; the remaining 75% may tell us a completely different story

  20. Estimating lithospheric properties at Atla Regio, Venus (United States)

    Phillips, Roger J.


    Magellan spehrical harmonic gravity and topography models are used to estimate lithospheric properties at Alta Regio, Venus, a proposed hotspot with dynamic support from mantle plume(s). Global spherical harmonic and local representations of the gravity field share common properties in the Atla region interms of their spectral behavior over a wavelength band from approximately 2100 to approximately 700 km. The estimated free-air admittance spectrum displays a rather featureless long-wavelength portion followed by a sharp rise at wavelengths shorter than about 1000 km. This sharp rise requires significant flexural support of short-wavelength structures. The Bouguer coherence also displays a sharp drop in this wavelength band, indicating a finite flexural rigidity of the lithosphere. A simple model for lithospheric loading from above and below is introduced (D. W. Forsyth, 1985) with four parameters: f, the ratio of bottom loading to top loading; z(sub m), crustal thickness; z(sub l) depth to bottom loading source; and T(sub e) elastic lithosphere thickness. A dual-mode compensation model is introduced in which the shorter wavelengths (lambda approximately less than 1000 km) might be explained best by a predominance of top loading by the large shield volcanoes Maat Mons, Ozza Mons, and Sapas Mons, and the longer wavelengths (lambda approximately greater than 1500 km) might be explained best by a deep depth of compensation, possibly representing bottom loading by a dynamic source. A Monte Carlo inversion technique is introduced to thoroughly search out the four-space of the model parameters and to examine parameter correlation in the solutions. Venus either is a considerabe deficient in heat sources relative to Earth, or the thermal lithosphere is overthickened in response to an earlier episode of significant heat loss from the planet.

  1. Transits of Venus and Colonial India (United States)

    Kochhar, Rajesh


    Astronomical expeditions during the colonial period had a political and national significance also. Measuring the earth and mapping the sky were activities worthy of powerful and power- seeking nations. Such was the sanctity of global astronomical activity that many other agendas could be hidden under it. An early astronomy-related expedition turned out to be extremely beneficial, to botany. The expedition sent by the French Government in 1735 to South America under the leadership of Charles Marie de la Condamine (1701--1774) ostensibly for the measurement of an arc of the meridian at Quito in Ecuador surreptitiously collected data that enabled Linnaeus to describe the genus cinchona in 1742. When the pair of transits of Venus occurred in 1761 and 1769, France and England were engaged in a bitter rivalry for control of India. The observation of the transits became a part of the rivalry. A telescope presented by the British to a South Indian King as a decorative toy was borrowed back for actual use. Scientifically the transit observations were a wash out, but the exercise introduced Europe to details of living Indian tradition of eclipse calculations. More significantly, it led to the institutionalization of modern astronomy in India under the auspices of the English East India Company (1787). The transits of Venus of 1874 and 1882 were important not so much for the study of the events as for initiating systematic photography of the Sun. By this, Britain owned most of the world's sunshine, and was expected to help European solar physicists get data from its vast Empire on a regular basis. This and the then genuinely held belief that a study of the sun would help predict failure of monsoons led to the institutionalization of solar physics studies in India (1899). Of course, when the solar physicists learnt that solar activity did not quite determine rainfall in India, they forgot to inform the Government.

  2. Changes in gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor gene expression after an increase in carbon monoxide concentration in the cavernous sinus of male wild boar and pig crossbread. (United States)

    Romerowicz-Misielak, M; Tabecka-Lonczynska, A; Koziol, K; Gilun, P; Stefanczyk-Krzymowska, S; Och, W; Koziorowski, M


    Previous studies indicate that there are at least a few regulatory systems involved in photoperiodic synchronisation of reproductive activity, which starts with the retina and ends at the gonadotropin-releasing hormone (GnRH) pulse generator. Recently we have shown indicated that the amount of carbon monoxide (CO) released from the eye into the ophthalmic venous blood depends on the intensity of sunlight. The aim of this study was to test whether changes in the concentration of carbon monoxide in the ophthalmic venous blood may modulate reproductive activity, as measured by changes in GnRH and GnRH receptor gene expression. The animal model used was mature male swine crossbred from wild boars and domestic sows (n = 48). We conducted in vivo experiments to determine the effect of increased CO concentrations in the cavernous sinus of the mammalian perihypophyseal vascular complex on gene expression of GnRH and GnRH receptors as well as serum luteinizing hormone (LH) levels. The experiments were performed during long photoperiod days near the summer solstice (second half of June) and short photoperiod days near the winter solstice (second half of December). These crossbred swine demonstrated a seasonally-dependent marked variation in GnRH and GnRH receptor gene expression and systemic LH levels in response to changes in CO concentration in ophthalmic venous blood. These results seem to confirm the hypothesis of humoral phototransduction as a mechanism for some of bright light's effects in animal chronobiology and the effect of CO on GnRH and GnRH receptor gene expression.

  3. Expression of Lymphocyte-derived Growth Hormone (GH) and GH-releasing Hormone Receptors in Aging Rats


    Weigent, Douglas A.


    In the present study, we show that higher levels of lymphocyte GH are expressed in spleen cells from aging animals compared to young animals. Further, leukocytes from primary and secondary immune tissues and splenic T and B cells from aging rats all express higher levels of GHRH receptors compared to younger animals. Bone marrow and splenic T cells express the highest levels of GHRH receptor in aging animals. Spleen cells from aging animals showed no significant change in proliferation or GH ...

  4. Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes

    International Nuclear Information System (INIS)

    Chien, Peter Tzu-Yu; Lin, Chih-Chung; Hsiao, Li-Der; Yang, Chuen-Mao


    Carbon monoxide (CO) is one of the cytoprotective byproducts of heme oxygenase (HO)-1 and exerts anti-inflammatory action in various models. However, the detailed mechanisms underlying CO-induced HO-1 expression in primary human cardiomyocytes remain largely unidentified. We used primary left ventricle myocytes as a model and applied CO releasing molecule (CORM)-2 to investigate the relationship of CO and HO-1 expression. We herein used Western blot, real-time PCR, promoter activity and EIA to investigate the role of HO-1 expression protecting against thrombin-mediated responses. We found that thrombin-induced COX-2 expression, PGE 2 release and cardiomyocyte hypertrophy markers (increase in ANF/BNP, α-actin expression and cell surface area) was attenuated by pretreatment with CORM-2 which was partially reversed by hemoglobin (Hb) or ZnPP (an inhibitor of HO-1 activity), suggesting that HO-1/CO system may be of clinical importance to ameliorate heart failure through inhibition of inflammatory responses. CORM-2-induced HO-1 protein expression, mRNA and promoter was attenuated by pretreatment with the inhibitors of Pyk2 (PF431396), PDGFR (AG1296), PI3K (LY294002), Akt (SH-5), p38 (SB202530), JNK1/2 (SP600125), FoxO1 (AS1842856) and Sp1 (mithramycin A). The involvement of these signaling components was further confirmed by transfection with respective siRNAs, consistent with those of pharmacological inhibitors. These results suggested that CORM-2-induced HO-1 expression is mediated through a Pyk2/PDGFR/PI3K/Akt/FoxO1/Sp1-dependent manner and exerts a cytoprotective effect in human cardiomyocytes. - Graphical abstract: In summary, CORM-2 treatment induces Pyk2 transactivated PDGFR, which induces PI3K/Akt/MAPK activation, and then recruits Sp1/Foxo1 transcriptional factors to regulate HO-1 gene expression in primary human cardiomyocytes. - Highlights: • CORM-2 induces HO-1 expression. • Pyk2-dependent PDGFR activates PI3K/Akt/MAPK pathway in CORM-2-induced HO-1

  5. Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes

    Energy Technology Data Exchange (ETDEWEB)

    Chien, Peter Tzu-Yu [Department of Physiology and Pharmacology and Health Ageing Research Center, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Lin, Chih-Chung; Hsiao, Li-Der [Department of Anesthetics, Chang Gung Memorial Hospital at Lin-Kou and College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Yang, Chuen-Mao, E-mail: [Department of Physiology and Pharmacology and Health Ageing Research Center, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan (China); Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan (China)


    Carbon monoxide (CO) is one of the cytoprotective byproducts of heme oxygenase (HO)-1 and exerts anti-inflammatory action in various models. However, the detailed mechanisms underlying CO-induced HO-1 expression in primary human cardiomyocytes remain largely unidentified. We used primary left ventricle myocytes as a model and applied CO releasing molecule (CORM)-2 to investigate the relationship of CO and HO-1 expression. We herein used Western blot, real-time PCR, promoter activity and EIA to investigate the role of HO-1 expression protecting against thrombin-mediated responses. We found that thrombin-induced COX-2 expression, PGE{sub 2} release and cardiomyocyte hypertrophy markers (increase in ANF/BNP, α-actin expression and cell surface area) was attenuated by pretreatment with CORM-2 which was partially reversed by hemoglobin (Hb) or ZnPP (an inhibitor of HO-1 activity), suggesting that HO-1/CO system may be of clinical importance to ameliorate heart failure through inhibition of inflammatory responses. CORM-2-induced HO-1 protein expression, mRNA and promoter was attenuated by pretreatment with the inhibitors of Pyk2 (PF431396), PDGFR (AG1296), PI3K (LY294002), Akt (SH-5), p38 (SB202530), JNK1/2 (SP600125), FoxO1 (AS1842856) and Sp1 (mithramycin A). The involvement of these signaling components was further confirmed by transfection with respective siRNAs, consistent with those of pharmacological inhibitors. These results suggested that CORM-2-induced HO-1 expression is mediated through a Pyk2/PDGFR/PI3K/Akt/FoxO1/Sp1-dependent manner and exerts a cytoprotective effect in human cardiomyocytes. - Graphical abstract: In summary, CORM-2 treatment induces Pyk2 transactivated PDGFR, which induces PI3K/Akt/MAPK activation, and then recruits Sp1/Foxo1 transcriptional factors to regulate HO-1 gene expression in primary human cardiomyocytes. - Highlights: • CORM-2 induces HO-1 expression. • Pyk2-dependent PDGFR activates PI3K/Akt/MAPK pathway in CORM-2-induced HO

  6. Expression of allelopathy in the soil environment: Soil concentration and activity of benzoxazinoid compounds released by rye cover crop residue (United States)

    The activity of allelopathic compounds is often reduced in the soil environment where processes involving release from donor plant material, soil adsorption and degradation, and uptake by receptor plants naturally result in complex interactions. Rye (Secale cereale L.) cover crops are known to supp...

  7. Origin and evolution of the atmospheres of early Venus, Earth and Mars (United States)

    Lammer, Helmut; Zerkle, Aubrey L.; Gebauer, Stefanie; Tosi, Nicola; Noack, Lena; Scherf, Manuel; Pilat-Lohinger, Elke; Güdel, Manuel; Grenfell, John Lee; Godolt, Mareike; Nikolaou, Athanasia


    We review the origin and evolution of the atmospheres of Earth, Venus and Mars from the time when their accreting bodies were released from the protoplanetary disk a few million years after the origin of the Sun. If the accreting planetary cores reached masses ≥ 0.5 M_Earth before the gas in the disk disappeared, primordial atmospheres consisting mainly of H_2 form around the young planetary body, contrary to late-stage planet formation, where terrestrial planets accrete material after the nebula phase of the disk. The differences between these two scenarios are explored by investigating non-radiogenic atmospheric noble gas isotope anomalies observed on the three terrestrial planets. The role of the young Sun's more efficient EUV radiation and of the plasma environment into the escape of early atmospheres is also addressed. We discuss the catastrophic outgassing of volatiles and the formation and cooling of steam atmospheres after the solidification of magma oceans and we describe the geochemical evidence for additional delivery of volatile-rich chondritic materials during the main stages of terrestrial planet formation. The evolution scenario of early Earth is then compared with the atmospheric evolution of planets where no active plate tectonics emerged like on Venus and Mars. We look at the diversity between early Earth, Venus and Mars, which is found to be related to their differing geochemical, geodynamical and geophysical conditions, including plate tectonics, crust and mantle oxidation processes and their involvement in degassing processes of secondary N_2 atmospheres. The buildup of atmospheric N_2, O_2, and the role of greenhouse gases such as CO_2 and CH_4 to counter the Faint Young Sun Paradox (FYSP), when the earliest life forms on Earth originated until the Great Oxidation Event ≈ 2.3 Gyr ago, are addressed. This review concludes with a discussion on the implications of understanding Earth's geophysical and related atmospheric evolution in relation

  8. Expression of multiple Src family kinases in sea urchin eggs and their function in Ca2+ release at fertilization. (United States)

    Townley, Ian K; Schuyler, Erin; Parker-Gür, Michelle; Foltz, Kathy R


    Egg activation at fertilization in deuterostomes requires a rise in intracellular Ca(2+), which is released from the egg's endoplasmic reticulum. In sea urchins, a Src Family Kinase (SpSFK1) is necessary for the PLCgamma-mediated signaling event that initiates this Ca(2+) release (Giusti, A.F., O'Neill, F.J., Yamasu, K., Foltz, K.R. and Jaffe, L.A., 2003. Function of a sea urchin egg Src family kinase in initiating Ca2+ release at fertilization. Dev. Biol. 256, 367-378.). Annotation of the Strongylocentrotus purpuratus genome sequence led to the identification of additional, predicted SFKs (Bradham, C.A., Foltz, D.R., Beane, W.S., Amone, M.I., Rizzo, F., Coffman, J.A., Mushegian, A., Goel, M., Morales, J., Geneviere, A.M., Lapraz, F., Robertson, A.J., Kelkar, H., Loza-Coll, M., Townley, I.K., Raisch, M., Roux, M.M., Lepage, T., Gache, C., McClay, D.R., Manning, G., 2006. The sea urchin kinome: a first look. Dev. Biol. 300, 180-193.; Roux, M.M., Townley, I.K., Raisch, M., Reade, A., Bradham, C., Humphreys, G., Gunaratne, H.J., Killian, C.E., Moy, G., Su, Y.H., Ettensohn, C.A., Wilt, F., Vacquier, V.D., Burke, R.D., Wessel, G. and Foltz, K.R., 2006. A functional genomic and proteomic perspective of sea urchin calcium signaling and egg activation. Dev. Biol. 300, 416-433.). Here, we describe the cloning and characterization of these 4 additional SFKs and test their function during the initial Ca(2+) release at fertilization using the dominant-interfering microinjection method coupled with Ca(2+) recording. While two of the new SFKs (SpFrk and SpSFK3) are necessary for Ca(2+) release, SpSFK5 appears dispensable for early egg to embryo transition events. Interestingly, SpSFK7 may be involved in preventing precocious release of Ca(2+). Binding studies indicate that only SpSFK1 is capable of direct interaction with PLCgamma. Immunolocalization studies suggest that one or more SpSFK and PLCgamma are localized to the egg cortex and at the site of sperm-egg interaction

  9. Expression and extracellular release of a functional anti-trypanosome Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly

    Directory of Open Access Journals (Sweden)

    De Vooght Linda


    Full Text Available Abstract Background Sodalis glossinidius, a gram-negative bacterial endosymbiont of the tsetse fly, has been proposed as a potential in vivo drug delivery vehicle to control trypanosome parasite development in the fly, an approach known as paratransgenesis. Despite this interest of S. glossinidius as a paratransgenic platform organism in tsetse flies, few potential effector molecules have been identified so far and to date none of these molecules have been successfully expressed in this bacterium. Results In this study, S. glossinidius was transformed to express a single domain antibody, (Nanobody® Nb_An33, that efficiently targets conserved cryptic epitopes of the variant surface glycoprotein (VSG of the parasite Trypanosoma brucei. Next, we analyzed the capability of two predicted secretion signals to direct the extracellular delivery of significant levels of active Nb_An33. We show that the pelB leader peptide was successful in directing the export of fully functional Nb_An33 to the periplasm of S. glossinidius resulting in significant levels of extracellular release. Finally, S. glossinidius expressing pelBNb_An33 exhibited no significant reduction in terms of fitness, determined by in vitro growth kinetics, compared to the wild-type strain. Conclusions These data are the first demonstration of the expression and extracellular release of functional trypanosome-interfering Nanobodies® in S. glossinidius. Furthermore, Sodalis strains that efficiently released the effector protein were not affected in their growth, suggesting that they may be competitive with endogenous microbiota in the midgut environment of the tsetse fly. Collectively, these data reinforce the notion for the potential of S. glossinidius to be developed into a paratransgenic platform organism.

  10. Nanoscale organization of {beta}{sub 2}-adrenergic receptor-Venus fusion protein domains on the surface of mammalian cells

    Energy Technology Data Exchange (ETDEWEB)

    Vobornik, Dusan; Rouleau, Yanouchka; Haley, Jennifer [Steacie Institute for Molecular Sciences, National Research Council Canada, Ottawa, ON, Canada K1A 0R6 (Canada); Bani-Yaghoub, Mahmud [Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada K1A 0R6 (Canada); Taylor, Rod [Steacie Institute for Molecular Sciences, National Research Council Canada, Ottawa, ON, Canada K1A 0R6 (Canada); Johnston, Linda J., E-mail: [Steacie Institute for Molecular Sciences, National Research Council Canada, Ottawa, ON, Canada K1A 0R6 (Canada); Pezacki, John Paul, E-mail: [Steacie Institute for Molecular Sciences, National Research Council Canada, Ottawa, ON, Canada K1A 0R6 (Canada)


    Adrenergic receptors are a key component of nanoscale multiprotein complexes that are responsible for controlling the beat rate in a mammalian heart. We demonstrate the ability of near-field scanning optical microscopy (NSOM) to visualize {beta}{sub 2}-adrenergic receptors ({beta}{sub 2}AR) fused to the GFP analogue Venus at the nanoscale on HEK293 cells. The expression of the {beta}{sub 2}AR-Venus fusion protein was tightly controlled using a tetracycline-induced promoter. Both the size and density of the observed nanoscale domains are dependent on the level of induction and thus the level of protein expression. At concentrations between 100 and 700 ng/ml of inducer doxycycline, the size of domains containing the {beta}{sub 2}AR-Venus fusion protein appears to remain roughly constant, but the number of domains per cell increase. At 700 ng/ml doxycycline the functional receptors are organized into domains with an average diameter of 150 nm with a density similar to that observed for the native protein on primary murine cells. By contrast, larger micron-sized domains of {beta}{sub 2}AR are observed in the membrane of the HEK293 cells that stably overexpress {beta}{sub 2}AR-GFP and {beta}{sub 2}AR-eYFP. We conclude that precise chemical control of gene expression is highly advantageous for the use {beta}{sub 2}AR-Venus fusion proteins as models for {beta}{sub 2}AR function. These observations are critical for designing future cell models and assays based on {beta}{sub 2}AR, since the receptor biology is consistent with a relatively low density of nanoscale receptor domains.

  11. In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice

    DEFF Research Database (Denmark)

    Rasmussen, Per; Vedel, J-C; Olesen, J


    Aim: Plasma interleukin-6 (IL-6) increases during exercise by release from active muscles and during prolonged exercise also from the brain. The IL-6 release from muscles continues into recovery and we tested whether the brain also releases IL-6 in recovery from prolonged exercise in humans....... Additionally, it was evaluated in mice whether brain release of IL-6 reflected enhanced IL-6 mRNA expression in the brain as modulated by brain glycogen levels. Methods: Nine healthy male subjects completed 4 h of ergometer rowing while the arterio-jugular venous difference (a-v diff) for IL-6 was determined....... The IL-6 mRNA and the glycogen content were determined in mouse hippocampus, cerebellum and cortex before and after 2 h treadmill running (N = 8). Results: At rest, the IL-6 a-v diff was negligible but decreased to -2.2 ± 1.9 pg ml(-1) at the end of exercise and remained low (-2.1 ± 2.1 pg ml(-1) ) 1 h...

  12. Venus Interior Probe Using In-situ Power and Propulsion (VIP-INSPR), Phase I (United States)

    National Aeronautics and Space Administration — We envision a novel architecture for Venus Interior Probes based on in-situ resources for power generation (VIP-INSPR). Proposed Venus probe is based on the...

  13. The Creation of a Beneficial Bioshpere from Co2 in the Clouds of Venus (United States)

    Linaraki, D. L.; Oungrinis, K. A.


    This research resulted in an architectural design for a Venus colony based on multiple factors combination, such as psychology of space, predicted near-future technology, and the identified environmental conditions on Venus.

  14. Venus - 3D Perspective View of Sapas Mons (United States)


    Sapas Mons is displayed in the center of this computer-generated three-dimensional perspective view of the surface of Venus. The viewpoint is located 527 kilometers (327 miles) northwest of Sapas Mons at an elevation of 4 kilometers (2.5 miles) above the terrain. Lava flows extend for hundreds of kilometers across the fractured plains shown in the foreground to the base of Sapas Mons. The view is to the southeast with Sapas Mons appearing at the center with Maat Mons located in the background on the horizon. Sapas Mons, a volcano 400 kilometers (248 miles) across and 1.5 kilometers (0.9 mile) high is located at approximately 8 degrees north latitude, 188 degrees east longitude, on the western edge of Atla Regio. Its peak sits at an elevation of 4.5 kilometers (2.8 miles) above the planet's mean elevation. Sapas Mons is named for a Phoenician goddess. The vertical scale in this perspective has been exaggerated 10 times. Rays cast in a computer intersect the surface to create a three-dimensional perspective view. Simulated color and a digital elevation map developed by the U.S. Geological Survey are used to enhance small-scale structure. The simulated hues are based on color images recorded by the Soviet Venera 13 and 14 spacecraft. The image was produced by the Solar System Visualization project and the Magellan Science team at the JPL Multimission Image Processing Laboratory and is a single frame from a video released at the April 22, 1992 news conference.

  15. Viral Vector Mediated Over-Expression of Estrogen Receptor–α in Striatum Enhances the Estradiol-induced Motor Activity in Female Rats and Estradiol Modulated GABA Release (United States)

    Schultz, Kristin N.; von Esenwein, Silke A.; Hu, Ming; Bennett, Amy L.; Kennedy, Robert T.; Musatov, Sergei; Toran-Allerand, C. Dominique; Kaplitt, Michael G.; Young, Larry J.; Becker, Jill B.


    Classical estrogen receptor signaling mechanisms involve estradiol binding to intracellular nuclear receptors (estrogen receptor-α (ERα) and estrogen receptor-β (ERβ)) to promote changes in protein expression. Estradiol can also exert effects within seconds to minutes, however, a timescale incongruent with genomic signaling. In the brain, estradiol rapidly potentiates stimulated dopamine release in the striatum of female rats and enhances spontaneous rotational behavior. Furthermore, estradiol rapidly attenuates the K+- evoked increase of GABA in dialysate. We hypothesize that these rapid effects of estradiol in the striatum are mediated by ERα located on the membrane of medium spiny GABAergic neurons. This experiment examined whether over-expression of ERα in the striatum would enhance the effect of estradiol on rotational behavior and the K+- evoked increase in GABA in dialysate. Ovariectomized female rats were tested for rotational behavior or underwent microdialysis experiments after unilateral intrastriatal injections of a recombinant adeno-associated virus (AAV) containing the human ERα cDNA (AAV.ERα) into the striatum; controls received either the same vector into areas outside the striatum or an AAV containing the human alkaline phosphatase gene into the striatum (AAV.ALP). Animals that received AAV.ERα in the striatum exhibited significantly greater estradiol-induced contralateral rotations compared to controls and exhibited behavioral sensitization of contralateral rotations induced by a low dose of amphetamine. ERα over-expression also enhanced the inhibitory effect of estradiol on K+- evoked GABA release suggesting that disinhibition of dopamine release from terminals in the striatum resulted in the enhanced rotational behavior. PMID:19211896

  16. Three-dimensional thermal structure of the South Polar Vortex of Venus (United States)

    Hueso, Ricardo; Garate-Lopez, Itziar; Garcia-Muñoz, Antonio; Sánchez-Lavega, Agustín


    We have analyzed thermal infrared images provided by the VIRTIS-M instrument aboard Venus Express (VEX) to obtain high resolution thermal maps of the Venus south polar region between 55 and 85 km altitudes. The maps investigate three different dynamical configurations of the polar vortex including its classical dipolar shape, a regularly oval shape and a transition shape between the different configurations of the vortex. We apply the atmospheric model described by García Muñoz et al. (2013) and a variant of the retrieval algorithm detailed in Grassi et al. (2008) to obtain maps of temperature over the Venus south polar region in the quoted altitude range. These maps are discussed in terms of cloud motions and relative vorticity distribution obtained previously (Garate-Lopez et al. 2013). Temperature maps retrieved at 55 - 63 km show the same structures that are observed in the ~5 µm radiance images. This altitude range coincides with the optimal expected values of the cloud top altitude at polar latitudes and magnitudes derived from the analysis of ~5 µm images are measured at this altitude range. We also study the imprint of the vortex on the thermal field above the cloud level which extends up to 80 km. From the temperature maps, we also study the vertical stability of different atmospheric layers. The cold collar is clearly the most statically stable structure at polar latitudes, while the vortex and subpolar latitudes show lower stability values. Furthermore, the hot filaments present within the vortex at 55-63 km exhibit lower values of static stability than their immediate surroundings.ReferencesGarate-Lopez et al. Nat. Geosci. 6, 254-257 (2013).García Muñoz et al. Planet. Space Sci. 81, 65-73 (2013).Grassi, D. et al. J. Geophys. Res. 113, 1-12 (2008).AcknowledgementsWe thank ESA for supporting Venus Express, ASI, CNES and the other national space agencies supporting VIRTIS on VEX and their principal investigators G. Piccioni and P. Drossart. This work

  17. The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release

    DEFF Research Database (Denmark)

    Smajilovic, Sanela; Clemmensen, Christoffer; Johansen, Lars Dan


    insulin secretion; therefore, the receptor has been hypothesized to have a role in regulating glucose metabolism. In this study, we demonstrate that GPRC6A is expressed in islets of Langerhans, but activation of the receptor by L-arginine did not stimulate insulin secretion. We also investigated central...... metabolic parameters in GPRC6A knockout mice compared with wildtype littermates and found no difference in glucose metabolism or body fat percentage when mice were administered a standard chow diet. In conclusion, our data do not support a role for GPRC6A in L-arginine-induced insulin release and glucose...

  18. IP3-dependent intracellular Ca2+ release is required for cAMP-induced c-fos expression in hippocampal neurons

    International Nuclear Information System (INIS)

    Zhang, Wenting; Tingare, Asmita; Ng, David Chi-Heng; Johnson, Hong W.; Schell, Michael J.; Lord, Rebecca L.; Chawla, Sangeeta


    Highlights: ► cAMP-induced c-fos expression in hippocampal neurons requires a submembraneous Ca 2+ pool. ► The submembraneous Ca 2+ pool derives from intracellular ER stores. ► Expression of IP 3 -metabolizing enzymes inhibits cAMP-induced c-fos expression. ► SRE-mediated and CRE-mediated gene expression is sensitive to IP 3 -metabolizing enzymes. ► Intracellular Ca 2+ release is required for cAMP-induced nuclear translocation of TORC1. -- Abstract: Ca 2+ and cAMP are widely used in concert by neurons to relay signals from the synapse to the nucleus, where synaptic activity modulates gene expression required for synaptic plasticity. Neurons utilize different transcriptional regulators to integrate information encoded in the spatiotemporal dynamics and magnitude of Ca 2+ and cAMP signals, including some that are Ca 2+ -responsive, some that are cAMP-responsive and some that detect coincident Ca 2+ and cAMP signals. Because Ca 2+ and cAMP can influence each other’s amplitude and spatiotemporal characteristics, we investigated how cAMP acts to regulate gene expression when increases in intracellular Ca 2+ are buffered. We show here that cAMP-mobilizing stimuli are unable to induce expression of the immediate early gene c-fos in hippocampal neurons in the presence of the intracellular Ca 2+ buffer BAPTA-AM. Expression of enzymes that attenuate intracellular IP 3 levels also inhibited cAMP-dependent c-fos induction. Synaptic activity induces c-fos transcription through two cis regulatory DNA elements – the CRE and the SRE. We show here that in response to cAMP both CRE-mediated and SRE-mediated induction of a luciferase reporter gene is attenuated by IP 3 metabolizing enzymes. Furthermore, cAMP-induced nuclear translocation of the CREB coactivator TORC1 was inhibited by depletion of intracellular Ca 2+ stores. Our data indicate that Ca 2+ release from IP 3 -sensitive pools is required for cAMP-induced transcription in hippocampal neurons.

  19. Late Veneer consequences on Venus' long term evolution (United States)

    Gillmann, C.; Golabek, G.; Tackley, P. J.; Raymond, S. N.


    Modelling of Venus' evolution is able to produce scenarios consistent with present-day observation. These results are however heavily dependent on atmosphere escape and initial volatile inventory. This primordial history (the first 500 Myr) is heavily influenced by collisions. We investigate how Late Veneer impacts change the initial state of Venus and their consequences on its coupled mantle/atmosphere evolution. We focus on volatile fluxes: atmospheric escape and mantle degassing. Mantle dynamics is simulated using the StagYY code. Atmosphere escape covers both thermal and non-thermal processes. Surface conditions are calculated with a radiative-convective model. Feedback of the atmosphere on the mantle through surface temperature is included. Large impacts are capable of contributing to atmospheric escape, volatile replenishment and energy transfer. We use the SOVA hydrocode to take into account volatile loss and deposition during a collision. Large impacts are not numerous enough to substantially erode Venus' atmosphere. Single impacts don't have enough eroding power. Swarms of small bodies (history of the planet and leads to lower present-day surface temperatures. Total depletion of the mantle seems unlikely, meaning either few large impacts (1 to 4) or low energy (slow, grazing…) collisions. Combined with the lack of plate tectonics and volatile recycling in the interior of Venus, Late Veneer collisions could help explain why Venus seems dry today.

  20. Venus: The First Habitable World of Our Solar System? (United States)

    Way, Michael Joseph; Del Genio, Anthony; Kiang, Nancy; Sohl, Linda; Clune, Tom; Aleinov, Igor; Kelley, Maxwell


    A great deal of effort in the search for life off-Earth in the past 20+ years has focused on Mars via a plethora of space and ground based missions. While there is good evidence that surface liquid water existed on Mars in substantial quantities, it is not clear how long such water existed. Most studies point to this water existing billions of years ago. However,those familiar with the Faint Young Sun hypothesis for Earth will quickly realize that this problem is even more pronounced for Mars. In this context recent simulations have been completed with the GISS 3-D GCM (1) of paleo Venus (approx. 3 billion years ago) when the sun was approx. 25 less luminous than today. A combination of a less luminous Sun and a slow rotation rate reveal that Venus could have had conditions on its surface amenable to surface liquid water. Previous work has also provided bounds on how much water Venus could have had using measured DH ratios. It is possible that less assumptions have to be made to make Venus an early habitable world than have to be made for Mars, even thoughVenus is a much tougher world on which to confirm this hypothesis.

  1. Where should one look for traces of life on Venus? (United States)

    Vidmachenko, A. P.


    Now Venus is not very similar to a suitable place for living. It surface temperature exceeds 730 K, the pressure is 90 atmospheres, the cloud layer consists of sulfur dioxide, and the fog above cloud is a solution of sulfuric acid. But about 3 billion years ago, this planet among the Earth-type planets within the Solar System was perhaps the most suitable place for the existence of some form of life there. Measurements of the ratio of hydrogen isotopes in the atmosphere also showed that the planet once had much more water, and perhaps it was enough even for the oceans. In early years on Venus was similar to the earth's climate, have a satisfactory temperature and oceans of liquid water. That is, under the above conditions with moderate temperature, sufficient heat and liquid water, Venus would be quite suitable for the emergence of certain microorganisms and for the existence of primitive life there, especially in the oceans. One way to check whether the ancient Venus was once covered by the oceans is the study of the tremolite found on Earth. It is necessary to hope to find the tremolite at some depth below the surface of Venus. Also necessary to search for some biosignals in the form of petrified remains, of possibly simple thermophilic microorganisms. We believe that such an experiment can be prepared and technically carried out during the next decades.

  2. Benchmark calculations for VENUS-2 MOX -fueled reactor dosimetry

    International Nuclear Information System (INIS)

    Kim, Jong Kung; Kim, Hong Chul; Shin, Chang Ho; Han, Chi Young; Na, Byung Chan


    As a part of a Nuclear Energy Agency (NEA) Project, it was pursued the benchmark for dosimetry calculation of the VENUS-2 MOX-fueled reactor. In this benchmark, the goal is to test the current state-of-the-art computational methods of calculating neutron flux to reactor components against the measured data of the VENUS-2 MOX-fuelled critical experiments. The measured data to be used for this benchmark are the equivalent fission fluxes which are the reaction rates divided by the U 235 fission spectrum averaged cross-section of the corresponding dosimeter. The present benchmark is, therefore, defined to calculate reaction rates and corresponding equivalent fission fluxes measured on the core-mid plane at specific positions outside the core of the VENUS-2 MOX-fuelled reactor. This is a follow-up exercise to the previously completed UO 2 -fuelled VENUS-1 two-dimensional and VENUS-3 three-dimensional exercises. The use of MOX fuel in LWRs presents different neutron characteristics and this is the main interest of the current benchmark compared to the previous ones

  3. Advancing Venus Geophysics with the NF4 VOX Gravity Investigation. (United States)

    Iess, L.; Mazarico, E.; Andrews-Hanna, J. C.; De Marchi, F.; Di Achille, G.; Di Benedetto, M.; Smrekar, S. E.


    The Venus Origins Explorer is a JPL-led New Frontiers 4 mission proposal to Venus to answer critical questions about the origin and evolution of Venus. Venus stands out among other planets as Earth's twin planet, and is a natural target to better understand our own planet's place, in our own Solar System but also among the ever-increasing number of exoplanetary systems. The VOX radio science investigation will make use of an innovative Ka-band transponder provided by the Italian Space Agency (ASI) to map the global gravity field of Venus to much finer resolution and accuracy than the current knowledge, based on the NASA Magellan mission. We will present the results of comprehensive simulations performed with the NASA GSFC orbit determination and geodetic parameter estimation software `GEODYN', based on a realistic mission scenario, tracking schedule, and high-fidelity Doppler tracking noise model. We will show how the achieved resolution and accuracy help fulfill the geophysical goals of the VOX mission, in particular through the mapping of subsurface crustal density or thickness variations that will inform the composition and origin of the tesserae and help ascertain the heat loss and importance of tectonism and subduction.

  4. A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

    DEFF Research Database (Denmark)

    Cai, Yunpeng; López-Ruiz, Elena; Wengel, Jesper


    Hyaluronic acid (HA) is an attractive biomaterial for osteoarthritis (OA) treatment due to inherent functional and compatibility properties as an endogenous knee joint component. In this work, we describe a HA-based hydrogel with the dual functionality of increased CD44-dependent chondrocyte......:3) for identifying designs displaying optimal engagement of OA patient-derived CD44-expressing chondrocytes. Correlation was found between cell binding and CD44 expression, with maximal binding exhibited at a HA/chitosan ratio of 7:3, that was 181% higher than CD44-negative MCF-7 cell control cells. Transfection...... agent-free uptake into OA chondrocytes of fluorescent 13-mer DNA oligonucleotides with a flanked locked nucleic acid (LNA) gapmer design, in contrast to naked siRNA, was demonstrated by confocal and flow cytometric analysis. A sustained and complete release over 5days was found with the 7:3 hydrogel...

  5. Tectonic evolution of Lavinia Planitia, Venus (United States)

    Squyres, Steven W.; Frank, Sharon L.; Mcgill, George E.; Solomon, Sean C.


    High resolution radar images from the Magellan spacecraft have revealed the first details of the morphology of the Lavinia Planitia region of Venus. Lavinia is a broad lowland over 2000 km across, centered at about 45 deg S latitude, 345 deg E longitude. Herein, the tectonic evolution of Lavinia is discussed, and its possible relationship to processes operating in the planet's interior. The discussion is restricted to the region from 37.3 to 52.6 deg S latitude and from about 340 to 0 deg E longitude. One of the most interesting characteristics of Lavinia is that the entire region possesses a regional tectonic framework of striking regularity. Lavinia is also transected by a complex pattern of belts of intense tectonic deformation known as ridge belts. Despite the gross topographic similarity of all of the ridge belts in Lavinia, they exhibit two rather distinct styles of near surface deformation. One is composed of sets of broad, arch-like ridges rising above the surrounding plains. In the other type, obvious fold-like ridges are rare to absent in the radar images. Both type show evidence for small amounts of shear distributed across the belts.

  6. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA). (United States)

    Nakamura, Yasuhiro; Hattangady, Namita G; Ye, Ping; Satoh, Fumitoshi; Morimoto, Ryo; Ito-Saito, Takako; Sugawara, Akira; Ohba, Koji; Takahashi, Kazuhiro; Rainey, William E; Sasano, Hironobu


    Aberrant expression of gonadotropin-releasing hormone receptor (GnRHR) has been reported in human adrenal tissues including aldosterone-producing adenoma (APA). However, the details of its expression and functional role in adrenals are still not clear. In this study, quantitative RT-PCR analysis revealed the mean level of GnRHR mRNA was significantly higher in APAs than in human normal adrenal (NA) (P=0.004). GnRHR protein expression was detected in human NA and neoplastic adrenal tissues. In H295R cells transfected with GnRHR, treatment with GnRH resulted in a concentration-dependent increase in CYP11B2 reporter activity. Chronic activation of GnRHR with GnRH (100nM), in a cell line with doxycycline-inducible GnRHR (H295R-TR/GnRHR), increased CYP11B2 expression and aldosterone production. These agonistic effects were inhibited by blockers for the calcium signaling pathway, KN93 and calmidazolium. These results suggest GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of APA. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  7. Osmotic regulation of expression of two extracellular matrix-binding proteins and a haemolysin of Leptospira interrogans: differential effects on LigA and Sph2 extracellular release. (United States)

    Matsunaga, James; Medeiros, Marco A; Sanchez, Yolanda; Werneid, Kristian F; Ko, Albert I


    The life cycle of the pathogen Leptospira interrogans involves stages outside and inside the host. Entry of L. interrogans from moist environments into the host is likely to be accompanied by the induction of genes encoding virulence determinants and the concomitant repression of genes encoding products required for survival outside of the host. The expression of the adhesin LigA, the haemolysin Sph2 (Lk73.5) and the outer-membrane lipoprotein LipL36 of pathogenic Leptospira species have been reported to be regulated by mammalian host signals. A previous study demonstrated that raising the osmolarity of the leptospiral growth medium to physiological levels encountered in the host by addition of various salts enhanced the levels of cell-associated LigA and LigB and extracellular LigA. In this study, we systematically examined the effects of osmotic upshift with ionic and non-ionic solutes on expression of the known mammalian host-regulated leptospiral genes. The levels of cell-associated LigA, LigB and Sph2 increased at physiological osmolarity, whereas LipL36 levels decreased, corresponding to changes in specific transcript levels. These changes in expression occurred irrespective of whether sodium chloride or sucrose was used as the solute. The increase of cellular LigA, LigB and Sph2 protein levels occurred within hours of adding sodium chloride. Extracellular Sph2 levels increased when either sodium chloride or sucrose was added to achieve physiological osmolarity. In contrast, enhanced levels of extracellular LigA were observed only with an increase in ionic strength. These results indicate that the mechanisms for release of LigA and Sph2 differ during host infection. Thus, osmolarity not only affects leptospiral gene expression by affecting transcript levels of putative virulence determinants but also affects the release of such proteins into the surroundings.

  8. Are basophil histamine release and high affinity IgE receptor expression involved in asymptomatic skin sensitization?

    DEFF Research Database (Denmark)

    Jensen, Bettina Margrethe; Assing, K; Jensen, Lone Hummelshøj


    Immunoglobulin (Ig)E-sensitized persons with positive skin prick test, but no allergy symptoms, are classified as being asymptomatic skin sensitized (AS). The allergic type 1 disease is dependant on IgE binding to the high affinity IgE-receptor (FcepsilonRI) expressed on basophils and mast cells....

  9. A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression. (United States)

    Greene, Trever T; Tokuyama, Maria; Knudsen, Giselle M; Kunz, Michele; Lin, James; Greninger, Alexander L; DeFilippis, Victor R; DeRisi, Joseph L; Raulet, David H; Coscoy, Laurent


    Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands. These are expressed at low level on healthy cells, but are induced by stresses like infection and transformation. The physiological events that drive NKG2D ligand expression during infection are still poorly understood. We observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D ligands. We demonstrate that RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II and preventing it from activating HDAC3. Accordingly, we found that HDAC inhibiting proteins from human herpesviruses induce human NKG2D ligand ULBP-1. Thus our findings indicate that virally mediated HDAC inhibition can act as a signal for the host to activate NK-cell recognition.

  10. Spectroscopic characterization of Venus at the single molecule level. (United States)

    David, Charlotte C; Dedecker, Peter; De Cremer, Gert; Verstraeten, Natalie; Kint, Cyrielle; Michiels, Jan; Hofkens, Johan


    Venus is a recently developed, fast maturating, yellow fluorescent protein that has been used as a probe for in vivo applications. In the present work the photophysical characteristics of Venus were analyzed spectroscopically at the bulk and single molecule level. Through time-resolved single molecule measurements we found that single molecules of Venus display pronounced fluctuations in fluorescence emission, with clear fluorescence on- and off-times. These fluorescence intermittencies were found to occupy a broad range of time scales, ranging from milliseconds to several seconds. Such long off-times can complicate the analysis of single molecule counting experiments or single-molecule FRET experiments. This journal is © The Royal Society of Chemistry and Owner Societies 2012

  11. Day and night models of the Venus thermosphere (United States)

    Massie, S. T.; Hunten, D. M.; Sowell, D. R.


    A model atmosphere of Venus for altitudes between 100 and 178 km is presented for the dayside and nightside. Densities of CO2, CO, O, N2, He, and O2 on the dayside, for 0800 and 1600 hours local time, are obtained by simultaneous solution of continuity equations. These equations couple ionospheric and neutral chemistry and the transport processes of molecular and eddy diffusion. Photodissociation and photoionization J coefficients are presented to facilitate the incorporation of chemistry into circulation models of the Venus atmosphere. Midnight densities of CO2 CO, O, N2, He, and N are derived from integration of the continuity equations, subject to specified fluxes. The nightside densities and fluxes are consistent with the observed airglow of NO and O2(1 Delta). The homopause of Venus is located near 133 km on both the dayside and nightside.

  12. Aeolian sand transport and aeolian deposits on Venus: A review (United States)

    Kreslavsly, Mikhail A.; Bondarenko, Nataliya V.


    We review the current state of knowledge about aeolian sand transport and aeolian bedforms on planet Venus. This knowledge is limited by lack of observational data. Among the four planetary bodies of the Solar System with sufficient atmospheres in contact with solid surfaces, Venus has the densest atmosphere; the conditions there are transitional between those for terrestrial subaerial and subaqueous transport. The dense atmosphere causes low saltation threshold and short characteristic saltation length, and short scale length of the incipient dunes. A few lines of evidence indicate that the typical wind speeds exceed the saltation threshold; therefore, sand transport would be pervasive, if sand capable of saltation is available. Sand production on Venus is probably much slower than on the Earth; the major terrestrial sand sinks are also absent, however, lithification of sand through sintering is expected to be effective under Venus' conditions. Active transport is not detectable with the data available. Aeolian bedforms (transverse dunes) resolved in the currently available radar images occupy a tiny area on the planet; however, indirect observations suggest that small-scale unresolved aeolian bedforms are ubiquitous. Aeolian transport is probably limited by sand lithification causing shortage of saltation-capable material. Large impact events likely cause regional short-term spikes in aeolian transport by supplying a large amount of sand-size particles, as well as disintegration and activation of older indurated sand deposits. The data available are insufficient to understand whether the global aeolian sand transport occurs or not. More robust knowledge about aeolian transport on Venus is essential for future scientific exploration of the planet, in particular, for implementation and interpretation of geochemical studies of surface materials. High-resolution orbital radar imaging with local to regional coverage and desirable interferometric capabilities is the

  13. Optimization of intrinsic and extrinsic tendon healing through controllable water-soluble mitomycin-C release from electrospun fibers by mediating adhesion-related gene expression. (United States)

    Zhao, Xin; Jiang, Shichao; Liu, Shen; Chen, Shuai; Lin, Zhi Yuan William; Pan, Guoqing; He, Fan; Li, Fengfeng; Fan, Cunyi; Cui, Wenguo


    To balance intrinsic and extrinsic healing during tendon repair is challenging in tendon surgery. We hypothesized that by mediating apoptotic gene and collagen synthesis of exogenous fibroblasts, the adhesion formation induced by extrinsic healing could be inhibited. With the maintenance of intrinsic healing, the tendon could be healed with proper function with no adhesion. In this study, we loaded hydrophilic mitomycin-C (MMC) into hyaluronan (HA) hydrosols, which were then encapsulated in poly(L-lactic acid) (PLLA) fibers by micro-sol electrospinning. This strategy successfully provided a controlled release of MMC to inhibit adhesion formations with no detrimental effect on intrinsic healing. We found that micro-sol electrospinning was an effective and facile approach to incorporate and control hydrophilic drug release from hydrophobic polyester fibers. MMC exhibited an initially rapid, and gradually steadier release during 40 days, and the release rates could be tuned by its concentration. In vitro studies revealed that low concentrations of MMC could inhibit fibroblast adhesion and proliferation. When lacerate tendons were healed using the MMC-HA loaded PLLA fibers in vivo, they exhibited comparable mechanical strength to the naturally healed tendons but with no significant presence of adhesion formation. We further identified the up-regulation of apoptotic protein Bax expression and down-regulation of proteins Bcl2, collage I, collagen III and α-SMA during the healing process associated with minimum adhesion formations. This approach presented here leverages new advances in drug delivery and nanotechnology and offers a promising strategy to balance intrinsic and extrinsic tendon healing through modulating genes associated with fibroblast apoptosis and collagen synthesis. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha (United States)

    Kia, Azadeh; McAvoy, Kevin; Krishnamurthy, Karthik; Trotti, Davide


    Mutations in fused in sarcoma (FUS) are linked to amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease affecting both upper and lower motor neurons. While it is established that astrocytes contribute to the death of motor neurons in ALS, the specific contribution of mutant FUS (mutFUS) through astrocytes has not yet been studied. Here, we used primary astrocytes expressing a N‐terminally GFP tagged R521G mutant or wild‐type FUS (WTFUS) and show that mutFUS‐expressing astrocytes undergo astrogliosis, damage co‐cultured motor neurons via activation of an inflammatory response and produce conditioned medium (ACM) that is toxic to motor neurons in isolation. Time lapse imaging shows that motor neuron cultures exposed to mutFUS ACM, but not WTFUS ACM, undergo significant cell loss, which is preceded by progressive degeneration of neurites. We found that Tumor Necrosis Factor‐Alpha (TNFα) is secreted into ACM of mutFUS‐expressing astrocytes. Accordingly, mutFUS astrocyte‐mediated motor neuron toxicity is blocked by targeting soluble TNFα with neutralizing antibodies. We also found that mutant astrocytes trigger changes to motor neuron AMPA receptors (AMPAR) that render them susceptible to excitotoxicity and AMPAR‐mediated cell death. Our data provide the first evidence of astrocytic involvement in FUS‐ALS, identify TNFα as a mediator of this toxicity, and provide several potential therapeutic targets to protect motor neurons in FUS‐linked ALS. PMID:29380416

  15. Simulation of Venus polar vortices with the non-hydrostatic general circulation model (United States)

    Rodin, Alexander V.; Mingalev, Oleg; Orlov, Konstantin


    The dynamics of Venus atmosphere in the polar regions presents a challenge for general circulation models. Numerous images and hyperspectral data from Venus Express mission shows that above 60 degrees latitude atmospheric motion is substantially different from that of the tropical and extratropical atmosphere. In particular, extended polar hoods composed presumably of fine haze particles, as well as polar vortices revealing mesoscale wave perturbations with variable zonal wavenumbers, imply the significance of vertical motion in these circulation elements. On these scales, however, hydrostatic balance commonly used in the general circulation models is no longer valid, and vertical forces have to be taken into account to obtain correct wind field. We present the first non-hydrostatic general circulation model of the Venus atmosphere based on the full set of gas dynamics equations. The model uses uniform grid with the resolution of 1.2 degrees in horizontal and 200 m in the vertical direction. Thermal forcing is simulated by means of relaxation approximation with specified thermal profile and time scale. The model takes advantage of hybrid calculations on graphical processors using CUDA technology in order to increase performance. Simulations show that vorticity is concentrated at high latitudes within planetary scale, off-axis vortices, precessing with a period of 30 to 40 days. The scale and position of these vortices coincides with polar hoods observed in the UV images. The regions characterized with high vorticity are surrounded by series of small vortices which may be caused by shear instability of the zonal flow. Vertical velocity component implies that in the central part of high vorticity areas atmospheric flow is downwelling and perturbed by mesoscale waves with zonal wavenumbers 1-4, resembling observed wave structures in the polar vortices. Simulations also show the existence of areas with strong vertical flow, concentrated in spiral branches extending

  16. Temperature and Wind Measurements in Venus Lower Thermosphere between 2007 and 2015 (United States)

    Krause, Pia; Sornig, Manuela; Wischnewski, Carolin; Sonnabend, Guido; Stangier, Tobias; Herrmann, Maren; Kostiuk, Theodor; Livengood, Timothy A.; Pätzold, Martin


    The structure of Venus atmosphere and its thermal and dynamical behavior was intensely studied during the past decade by groundbased and the space mission Venus Express. A comprehensive understanding of the atmosphere, however, is still missing. Direct measurements of atmospheric parameters on various time scales and at different locations across the planet are essential for better understanding and to validate global circulation models. Line-resolved spectroscopy of infrared CO2 transitions provides a powerful tool to accomplish measurements of temperature and wind speed within the neutral atmosphere, using Doppler line-broadening and Doppler shift. Temperature is the motor to drive circulation, and wind speed is the result. Measuring both provides both the basis and an empirical test for circulation models. Non-LTE emission lines at 10 µm that originate from a pressure level of 1μbar, ~110 km altitude, probe the lower thermosphere and are measurable at high spectral resolution using the infrared heterodyne spectrometers THIS (University of Cologne), HIPWAC (NASA GSFC) and MILAHI (Tohoku University).Thermal and dynamical structures on the Venus day side are retrieved using a newly developed method that considers the influence of the spectrometer field-of-view (FoV) and the dispersion of spectral properties across the FoV. New conclusions from the ground-based observing campaigns between 2007 and 2015 will be presented based on this retrieval methodology. The spatial resolution on the planetary disk is different for each campaign, depending on the apparent diameter of the planet and the diffraction-limited FoV of the telescope. Previously, a comparison of the observing campaigns was limited due to the difference in spatial resolution. The new retrieval method enables comparing observations with different observing geometry. The observations yield a large quantity of temperature and wind measurements at different positions on the planetary disk, which supports

  17. Mars ionopause during solar minimum: A lesson from Venus

    International Nuclear Information System (INIS)

    Mahajan, K.K.; Mayr, H.G.


    The ion densities measured by the Viking landers (Hanson et al., 1977) do not show an abrupt falloff with height, giving the false impression that Mars has no ionopause. On the basis of knowledge gained from the solar wind interaction at Venus during solar minimum, they demonstrate that the observed O 2 + profile above about 160 km on Mars is a distributed photodynamical ionosphere and can produce an ionopause at around 325 km, similar to that observed on Venus during solar minimum. They conclude that the solar wind interacts directly with the Mars ionosphere, suggesting that the planet does not have an intrinsic magnetic field of any consequence

  18. High Altitude Venus Operations Concept Trajectory Design, Modeling and Simulation (United States)

    Lugo, Rafael A.; Ozoroski, Thomas A.; Van Norman, John W.; Arney, Dale C.; Dec, John A.; Jones, Christopher A.; Zumwalt, Carlie H.


    A trajectory design and analysis that describes aerocapture, entry, descent, and inflation of manned and unmanned High Altitude Venus Operation Concept (HAVOC) lighter-than-air missions is presented. Mission motivation, concept of operations, and notional entry vehicle designs are presented. The initial trajectory design space is analyzed and discussed before investigating specific trajectories that are deemed representative of a feasible Venus mission. Under the project assumptions, while the high-mass crewed mission will require further research into aerodynamic decelerator technology, it was determined that the unmanned robotic mission is feasible using current technology.

  19. Magnetic field overshoots in the Venus blow shock

    International Nuclear Information System (INIS)

    Tatrallyay, M.; Luhmann, J.G.; Russell, C.T.


    An examination of Pioneer Venus Orbiter fluxgate magnetometer data has shown that magnetic field overshoots occur not only behind quasi-perpendicular bow shocks but also behind quasi-parallel shocks. Overshoots are assocciated only with supercritical shocks. Their amplitudes increase with increasing fast Mach number. Solar wind beta has a lesser effect. The thickness of the overshoot increases with decreasing Theta-BN. The thickness of apparent overshoots detected behind 4 strong fast interplanetary shocks (M greater than M/crit) is about 3 orders of magnitude larger. Multiple crossings of the Venus bow shock were observed mainly at turbulent shocks. Their occurence is not influenced by Theta-BN. 15 references

  20. Stratigraphy and Observations of Nepthys Mons Quadrangle (V54), Venus (United States)

    Bridges, N. T.


    Initial mapping has begun in Venus' Nepthys Mons Quadrangle (V54, 300-330 deg. E, 25-50 deg. S). Major research areas addressed are how the styles of volcanism and tectonism have changed with time, the evolution of shield volcanoes, the evolution of coronae, the characteristics of plains volcanism, and what these observations tell us about the general geologic history of Venus. Reported here is a preliminary general stratigraphy and several intriguing findings. Additional information is contained in the original extended abstract.

  1. Propagation of the trip behavior in the VENUS vertex chamber

    International Nuclear Information System (INIS)

    Ohama, Taro; Yamada, Yoshikazu.


    The high voltage system of the VENUS vertex chamber occasionally trips by a discharge somewhere among cathode electrodes during data taking. This trip behavior induces often additional trips at other electrodes such as the skin and the grid electrodes in the vertex chamber. This propagation mechanism of trips is so complicated in this system related with multi-electrodes. Although the vertex chamber is already installed inside the VENUS detector and consequently the discharge is not able to observe directly, a trial to estimate the propagation has been done using only the information which appears around the trip circuits and the power supply of the vertex chamber. (author)

  2. Krypton and xenon in the atmosphere of Venus (United States)

    Donahue, T. M.; Hoffman, J. H.; Hodges, R. R., Jr.


    The paper reports a determination by the Pioneer Venus large probe neutral mass spectrometer of upper limits to the concentration of krypton and xenon along with most of their isotopes in the atmosphere of Venus. The upper limit to the krypton mixing ratio is estimated at 47 ppb, with a very conservative estimate at 69 ppb. The probable upper limit to the sum of the mixing ratios of the isotopes Xe-128, Xe-129, Xe-130, Xe-131, and Xe-132 is 40 ppb by volume, with a very conservative upper limit three times this large.

  3. Effects of forced swimming stress on thyroid function, pituitary thyroid-stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats. (United States)

    Sun, Qiuyan; Liu, Aihua; Ma, Yanan; Wang, Anyi; Guo, Xinhong; Teng, Weiping; Jiang, Yaqiu


    In order to study the impact that is imposed on the hypothalamic-pituitary-thyroid (HPT) axis of adrenalectomy male Wistar rats by stress caused by swimming, the blood level of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH), the expression of TSHβ mRNA at the pituitary and thyrotropin releasing hormone (TRH) expression at the paraventricular nucleus (PVN) were measured. A total of 50 male Wistar rats of 6-8 weeks of age and with an average weight of 190-210 grams were randomly divided into the following two groups: The surgical (without adrenal glands) and non-surgical (adrenalectomy) group. These two groups were then divided into the following five groups, according to the time delay of sacrifice following forced swim (10 min, 2 h, 12 h and 24 h) and control (not subjected to swimming) groups. A bilateral adrenalectomy animal model was established. Serum TSH in the blood was measurement by chemiluminescent immunoassay, and cerebrum tissue were excised for the measurement of TRH expression using an immunohistochemistry assay. In addition, pituitaries were excised for the extraction of total RNA. Finally, reverse transcription-quantitative polymerase chain reaction was performed for quantitation of TSHβ. Following swimming, the serum T3, T4 and TSH, the TSHβ mRNA expression levels in the pituitary and the TRH expression in the PVN of the surgical group were gradually increased. In the non-surgical group, no significant differences were observed in the serum T3, T4 and TSH levels compared with the control group. The TSHβ mRNA expression at the pituitary showed a similar result. Furthermore, the TRH expression at PVN was gradually increased and stress from swimming could increase the blood T4, T3 and TSH levels, TSHβ mRNA expression at the pituitary and TRH expression at the PVN in adrenalectomy Wistar rats. Moreover, the index in the surgical group changed significantly compared with the non-surgical group. In conclusion, the results

  4. Magnetic Field Control of the Entry into the Ionosphere of Whistler-Mode Waves Produced by Venus Lightning (United States)

    Russell, Christopher; Wei, Hanying; Zhang, Tielong

    The sampling rate of the Venus Express fluxgate magnetometer was set so that it could register the 100 Hz signals previously reported by the electric antenna on the Pioneer Venus Orbiter. At least two minutes of each periapsis pass is devoted to recording at 128 Hz. Many of these passes do observe signals near 100 Hz, and these signals invariably have the properties expected for whistler-mode waves. They are nearly circularly polarized, and they propagate very closely to along the magnetic field. The waves are also only a fraction of a second in duration. They do not occur every orbit. The magnetic field is often nearly horizontal throughout the periapsis pass. When it is, no signals are seen. When the field deviates more than 15o from the horizontal, signals can reach the spacecraft but they again are not always present. The number 15o is quite similar to the size of the cone of non-propagation of the whistler-mode perpendicular to the magnetic field. Thus this observation, too, is consistent with a cloud level source of electric discharges whose electromagnetic radiation is refracted along the vertical upon entering the ionosphere. Only when and where this field is inclined to the horizontal can the signal enter the ionosphere. We continue to refine our estimate of the rate of lightning on Venus, but it is clear that the rate is very significant, comparable to activity in the terrestrial atmosphere.

  5. Morbillivirus glycoprotein expression induces ER stress, alters Ca2+ homeostasis and results in the release of vasostatin.

    Directory of Open Access Journals (Sweden)

    Jean-Marc Brunner

    Full Text Available Although the pathology of Morbillivirus in the central nervous system (CNS is well described, the molecular basis of neurodegenerative events still remains poorly understood. As a model to explore Morbillivirus-mediated CNS dysfunctions, we used canine distemper virus (CDV that we inoculated into two different cell systems: a monkey cell line (Vero and rat primary hippocampal neurons. Importantly, the recombinant CDV used in these studies not only efficiently infects both cell types but recapitulates the uncommon, non-cytolytic cell-to-cell spread mediated by virulent CDVs in brain of dogs. Here, we demonstrated that both CDV surface glycoproteins (F and H markedly accumulated in the endoplasmic reticulum (ER. This accumulation triggered an ER stress, characterized by increased expression of the ER resident chaperon calnexin and the proapoptotic transcription factor CHOP/GADD 153. The expression of calreticulin (CRT, another ER resident chaperon critically involved in the response to misfolded proteins and in Ca(2+ homeostasis, was also upregulated. Transient expression of recombinant CDV F and H surface glycoproteins in Vero cells and primary hippocampal neurons further confirmed a correlation between their accumulation in the ER, CRT upregulation, ER stress and disruption of ER Ca(2+ homeostasis. Furthermore, CDV infection induced CRT fragmentation with re-localisation of a CRT amino-terminal fragment, also known as vasostatin, on the surface of infected and neighbouring non-infected cells. Altogether, these results suggest that ER stress, CRT fragmentation and re-localization on the cell surface may contribute to cytotoxic effects and ensuing cell dysfunctions triggered by Morbillivirus, a mechanism that might potentially be relevant for other neurotropic viruses.

  6. Chronic ethanol consumption modulates growth factor release, mucosal cytokine production, and microRNA expression in nonhuman primates. (United States)

    Asquith, Mark; Pasala, Sumana; Engelmann, Flora; Haberthur, Kristen; Meyer, Christine; Park, Byung; Grant, Kathleen A; Messaoudi, Ilhem


    Chronic alcohol consumption has been associated with enhanced susceptibility to both systemic and mucosal infections. However, the exact mechanisms underlying this enhanced susceptibility remain incompletely understood. Using a nonhuman primate model of ethanol (EtOH) self-administration, we examined the impact of chronic alcohol exposure on immune homeostasis, cytokine, and growth factor production in peripheral blood, lung, and intestinal mucosa following 12 months of chronic EtOH exposure. EtOH exposure inhibited activation-induced production of growth factors hepatocyte growth factor (HGF), granulocyte colony-stimulating factor (G-CSF), and vascular-endothelial growth factor (VEGF) by peripheral blood mononuclear cells (PBMC). Moreover, EtOH significantly reduced the frequency of colonic Th1 and Th17 cells in a dose-dependent manner. In contrast, we did not observe differences in lymphocyte frequency or soluble factor production in the lung of EtOH-consuming animals. To uncover mechanisms underlying reduced growth factor and Th1/Th17 cytokine production, we compared expression levels of microRNAs in PBMC and intestinal mucosa. Our analysis revealed EtOH-dependent up-regulation of distinct microRNAs in affected tissues (miR-181a and miR-221 in PBMC; miR-155 in colon). Moreover, we were able to detect reduced expression of the transcription factors STAT3 and ARNT, which regulate expression of VEGF, G-CSF, and HGF and contain targets for these microRNAs. To confirm and extend these observations, PBMC were transfected with either mimics or antagomirs of miR-181 and miR-221, and protein levels of the transcription factors and growth factors were determined. Transfection of microRNA mimics led to a reduction in both STAT3/ARNT as well as VEGF/HGF/G-CSF levels. The opposite outcome was observed when microRNA antagomirs were transfected. Chronic EtOH consumption significantly disrupts both peripheral and mucosal immune homeostasis, and this dysregulation may be

  7. Aerobraking at Venus: A science and technology enabler (United States)

    Hibbard, Kenneth; Glaze, Lori; Prince, Jill


    Venus remains one of the great unexplored planets in our solar system, with key questions remaining on the evolution of its atmosphere and climate, its volatile cycles, and the thermal and magmatic evolution of its surface. One potential approach toward answering these questions is to fly a reconnaissance mission that uses a multi-mode radar in a near-circular, low-altitude orbit of ∼400 km and 60-70° inclination. This type of mission profile results in a total mission delta-V of ∼4.4 km/s. Aerobraking could provide a significant portion, potentially up to half, of this energy transfer, thereby permitting more mass to be allocated to the spacecraft and science payload or facilitating the use of smaller, cheaper launch vehicles.Aerobraking at Venus also provides additional science benefits through the measurement of upper atmospheric density (recovered from accelerometer data) and temperature values, especially near the terminator where temperature changes are abrupt and constant pressure levels drop dramatically in altitude from day to night.Scientifically rich, Venus is also an ideal location for implementing aerobraking techniques. Its thick lower atmosphere and slow planet rotation result in relatively more predictable atmospheric densities than Mars. The upper atmosphere (aerobraking altitudes) of Venus has a density variation of 8% compared to Mars' 30% variability. In general, most aerobraking missions try to minimize the duration of the aerobraking phase to keep costs down. These short phases have limited margin to account for contingencies. It is the stable and predictive nature of Venus' atmosphere that provides safer aerobraking opportunities.The nature of aerobraking at Venus provides ideal opportunities to demonstrate aerobraking enhancements and techniques yet to be used at Mars, such as flying a temperature corridor (versus a heat-rate corridor) and using a thermal-response surface algorithm and autonomous aerobraking, shifting many daily ground

  8. VENUS-2, Reactor Kinetics with Feedback, 2-D LMFBR Disassembly Excursions

    International Nuclear Information System (INIS)

    Jackson, J.F.; Nicholson, R.B.; Weber, D.P.


    1 - Description of problem or function: VENUS-2 is an improved edition of the VENUS fast-reactor disassembly program. It is a two- dimensional (r-z) coupled neutronics-hydrodynamics code that calculates the dynamic behavior of an LMFBR during a prompt-critical disassembly excursion. It calculates the power history and fission energy release as well as the space-time histories of the fuel temperatures, core material pressures, and core material motions. Reactivity feedback effects due to Doppler broadening and reactor material motion are taken into account. 2 - Method of solution: The power and energy release are calculated using a point-kinetics formulation with up to six delayed neutron groups. The reactivity is a combination of an input driving function and feedback effects due to Doppler broadening and material motion. An adiabatic model is used to calculate the temperature increase throughout the reactor based on an initial temperature distribution and power profile provided as input data. These temperatures are, in turn, converted to fuel pressures through one of several equation of state options provided. The material motion that results from the pressure buildup is calculated by a direct finite difference solution of a set of two-dimensional (r-z) hydrodynamics equations. This is done in Lagrangian coordinates. The reactivity change associated with this motion is calculated by first-order perturbation theory. The displacements are also used to adjust the fuel densities as required for the density dependent equation-of- state option. An automatic time-step-size selection scheme is provided. 3 - Restrictions on the complexity of the problem: VENUS-2 is written so that the dimensions of the storage arrays can be readily changed to accommodate a broad range of problem sizes. In the base version, the total number of mesh intervals is restricted such that (NR+3)*(NZ+3) is less than 700, where NR and NZ are the total number of mesh intervals in the r and z

  9. Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala (United States)

    Flandreau, Elizabeth I.; Bourke, Chase H.; Ressler, Kerry J.; Vale, Wylie W.; Nemeroff, Charles B.; Owens, Michael J.


    Summary We have previously demonstrated that viral-mediated overexpression of corticotropin-releasing factor (CRF) within the central nucleus of the amygdala (CeA) reproduces many of the behavioral and endocrine consequences of chronic stress. The present experiment sought to determine whether administration of the selective serotonin reuptake inhibitor (SSRI) escitalopram reverses the adverse effects of CeA CRF overexpression. In a 2 × 2 design, adult male rats received bilateral infusions of a control lentivirus or a lentivirus in which a portion of the CRF promoter is used to drive increased expression of CRF peptide. Four weeks later, rats were then implanted with an Alzet minipump to deliver vehicle or 10 mg/kg/day escitalopram for a 4-week period of time. The defensive withdrawal (DW) test of anxiety and the sucrose-preference test (SPT) of anhedonia were performed both before and after pump implantation. Additional post-implant behavioral tests included the elevated plus maze (EPM) and social interaction (SI) test. Following completion of behavioral testing, the dexamethasone/CRF test was performed to assess HPA axis reactivity. Brains were collected and expression of HPA axis-relevant transcripts were measured using in situ hybridization. Amygdalar CRF overexpression increased anxiety-like behavior in the DW test at week eight, which was only partially prevented by escitalopram. In both CRF-overexpressing and control groups, escitalopram decreased hippocampal CRF expression while increasing hypothalamic and hippocampal expression of the glucocorticoid receptor (GR). These gene expression changes were associated with a significant decrease in HPA axis reactivity in rats treated with escitalopram. Interestingly, escitalopram increased the rate of weight gain only in rats overexpressing CRF. Overall these data support our hypothesis that amygdalar CRF is critical in anxiety-like behavior; because the antidepressant was unable to reverse behavioral

  10. Effect of a hormone-releasing intrauterine system (Mirena® on aromatase and Cox-2 expression in patients with adenomyosis submitted or not, to endometrial resection

    Directory of Open Access Journals (Sweden)

    Maia R


    Full Text Available Hugo Maia Jr1,2, Clarice Haddad1, Julio Casoy1, Rebeca Maia1, Nathanael Pinheiro3, Elsimar M Coutinho11Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH, 2Itaigara Memorial Day Hospital, 3IMAGEPAT, Salvador, Bahia, BrazilObjective: To investigate the effect of a levonorgestrel-releasing intrauterine system (Mirena® on aromatase and cyclooxygenase-2 (Cox-2 expression in the endometrium of patients with adenomyosis who were submitted to endometrial resection at the time of insertion, compared to a group not submitted to endometrial resection and a group of controls with adenomyosis not submitted to any previous hormonal treatment.Patients and methods: Patients with adenomyosis (n = 89 were included in this study. Twenty-two patients had been using Mirena® for 5 years but had not been submitted to endometrial resection prior to insertion of the device. Twenty-four patients were submitted to endometrial resection at the time of Mirena® insertion. The remaining 43 patients with adenomyosis had undergone no previous hormonal treatment and served as a control group. Cox-2 and aromatase expression were determined in the endometrium by immunohistochemistry.Results: Use of Mirena® for 5 years reduced aromatase expression in the endometrium; however, this reduction was significantly greater in the uteri previously submitted to endometrial resection. The reduction in Cox-2 expression was significant only in the uteri submitted to endometrial resection followed by the insertion of Mirena®.Conclusion: Endometrial resection followed by the insertion of Mirena® was associated with greater rates of amenorrhea in patients with adenomyosis, which in turn were associated with a more effective inhibition of aromatase and Cox-2 expression in the endometrium.Keywords: aromatase, Mirena®, adenomyosis, Cox-2, endometrium, levonorgestrel

  11. Differential effects of stress and amphetamine administration on Fos-like protein expression in corticotropin releasing factor-neurons of the rat brain. (United States)

    Rotllant, David; Nadal, Roser; Armario, Antonio


    Corticotropin releasing factor (CRF) appears to be critical for the control of important aspects of the behavioral and physiological response to stressors and drugs of abuse. However, the extent to which the different brain CRF neuronal populations are similarly activated after stress and drug administration is not known. We then studied, using double immunohistochemistry for CRF and Fos protein, stress and amphetamine-induced activation of CRF neurons in cortex, central amygdala (CeA), medial parvocellular dorsal, and submagnocellular parvocellular regions of the paraventricular nucleus of the hypothalamus (PVNmpd and PVNsm, respectively) and Barrington nucleus (Bar). Neither exposure to a novel environment (hole-board, HB) nor immobilization (IMO) increased Fos-like immunoreactivity (FLI) in the CeA, but they did to the same extent in cortical regions. In other regions only IMO increased FLI. HB and IMO both failed to activate CRF+ neurons in cortical areas, but after IMO, some neurons expressing FLI in the PVNsm and most of them in the PVNmpd and Bar were CRF+. Amphetamine administration increased FLI in cortical areas and CeA (with some CRF+ neurons expressing FLI), whereas the number of CRF+ neurons increased only in the PVNsm, in contrast to the effects of IMO. The present results indicate that stress and amphetamine elicited a distinct pattern of brain Fos-like protein expression and differentially activated some of the brain CRF neuronal populations, despite similar levels of overall FLI in the case of IMO and amphetamine.

  12. Photoelectron reflection and scattering at Venus: an upper limit on the "polar wind" ambipolar electric field, and a new source of top-side ionospheric heating (United States)

    Collinson, Glyn; Glocer, Alex; Grebowsky, Joe; Peterson, William; Frahm, Rudy; Moore, Thomas; Gilbert, Lin; Coates, Andrew


    An important mechanism in the generation of Earth's polar wind is the ambipolar potential generated by the outflow along open field lines of superthermal electrons. This ≈20V electric potential assists ions in overcoming the gravitational potential, and is a key mechanism for Terrestrial ionospheric escape. At Venus, except in rare circumstances, every field line is open, and a similar outflow of ionospheric electrons is observed. It is thus hypothesized that a similar electric potential may be present at Venus, contributing to global ionospheric loss. However, a very sensitive electric field instrument would be required to directly measure this potential, and no such instrument has yet been flown to Venus. In this pilot study, we examine photoelectron spectra measured by the ASPERA-ELS instrument on the Venus Express to put an initial upper bound on the total potential drop above 350km of Φ current understanding, a "polar wind" like ambipolar electric field may not be as important a mechanism for atmospheric escape as previously suspected. Additionally, we find our spectra are consistent with the scattering of photoelectrons, the heating from which which we hypothesize may act as a source of top-side ionospheric heating, and may play a role in influencing the scale height of the ionosphere.

  13. Chronic Anabolic Androgenic Steroid Exposure Alters Corticotropin Releasing Factor Expression and Anxiety-Like Behaviors in the Female Mouse (United States)

    Costine, Beth A; Oberlander, Joseph G; Davis, Matthew C; Penatti, Carlos A A; Porter, Donna M; Leaton, Robert N; Henderson, Leslie P


    Summary In the past several decades, the therapeutic use of anabolic androgenic steroids (AAS) has been overshadowed by illicit use of these drugs by elite athletes and a growing number of adolescents to enhance performance and body image. As with adults, AAS use by adolescents is associated with a range of behavioral effects, including increased anxiety and altered responses to stress. It has been suggested that adolescents, especially adolescent females, may be particularly susceptible to the effects of these steroids, but few experiments in animal models have been performed to test this assertion. Here we show that chronic exposure of adolescent female mice to a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and methandrostenolone; 7.5 mg/kg/day for 5 days) significantly enhanced anxiety-like behavior as assessed by the acoustic startle response (ASR), but did not augment the fear-potentiated startle response (FPS) or alter sensorimotor gating as assessed by prepulse inhibition of the acoustic startle response (PPI). AAS treatment also significantly increased the levels of corticotropin releasing factor (CRF) mRNA and somal-associated CRF immunoreactivity in the central amygdala (CeA), as well as neuropil-associated immunoreactivity in the dorsal aspect of the anterolateral division of the bed nucleus of the stria terminalis (dBnST). AAS treatment did not alter CRF receptor 1 or 2 mRNA in either the CeA or the dBnST; CRF immunoreactivity in the ventral BNST, the paraventricular nucleus (PVN) or the median eminence (ME); or peripheral levels of corticosterone. These results suggest that chronic AAS treatment of adolescent female mice may enhance generalized anxiety, but not sensorimotor gating or learned fear, via a mechanism that involves increased CRF-mediated signaling from CeA neurons projecting to the dBnST. PMID:20537804

  14. Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo

    Directory of Open Access Journals (Sweden)

    Wei Kevin Zhang


    Full Text Available Background: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain. Methods and Results: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree. Conclusions: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.

  15. Astronomers, Transits of Venus, and the Birth of Experimental Psychology (United States)

    Sheehan, William; Thurber, S.


    The eighteenth century transits of Venus were regarded as the most important astronomical events of their era. Halley's expectation was that by observing the contact points between the limbs of Venus and the Sun, this distance could be determined to an accuracy of one part in 500. But in the event, it proved otherwise. But, as the British historian Agnes Clerke wrote in 1902: "A transit of Venus seems, at first sight, full of promise for solving the problem of the sun's distance. For nothing would appear easier than to determine exactly either the duration of the passage of a small, dark orb across a large brilliant disc, or the instant of its entry upon or exit from it". But in that word `exactly' what snares and pitfalls lie hid!” In the post-mortem analysis of the disappointing results, astronomers devoted a great deal of effort to understand the sources of errors. They rehearsed their observational techniques by observing, under strictly controlled conditions, transits of artificial planets across artificial Suns, and studied such parameters as attention and reflex reaction. In the process, the transits of Venus provided an important impetus to the early development of experimental psychology.

  16. The 1761 discovery of Venus' atmosphere: Lomonosov and others (United States)

    Shiltsev, Vladimir


    Russian polymath Mikhail Vasil'evich Lomonosov claimed to have discovered the atmosphere of Venus during the planet's transit over the Sun's disc in 1761. Although several other astronomers observed similar effects during the 1761 and 1769 transits, Lomonosov's claim for priority is the strongest as he was the first to publish a comprehensive scientific report, and the first to offer a detailed explanation of the aureole around Venus at ingress and egress, which was caused by refraction of the sunlight through Venus' atmosphere. His observations, moreover, were successfully reconstructed experimentally using antique telescopes during the 2012 transit. In this paper we review details of Lomonosov's observations (which usually are poorly covered by commentators and often misunderstood); compare other reports of the eighteenth century transit observations, and summarize their findings in a comprehensive table; and address recent calls to reconsider Lomonosov's priority. After reviewing the available documentation we conclude that everything we learned before, during and after the twenty-first century transits only supports further the widely-accepted attribution of the discovery of Venus' atmosphere to Lomonosov.

  17. The transit of Venus enterprise in Victorian Britain

    CERN Document Server

    Ratcliff, Jessica


    In nineteenth century, the British Government spent money measuring the distance between the earth and the sun using observations of the transit of Venus. This book presents a narrative of the two Victorian transit programmes. It draws out their cultural significance and explores the nature of 'big science' in late-Victorian Britain.

  18. Investigating circular patterns in linear polarization observations of Venus

    NARCIS (Netherlands)

    Mahapatra, G.; Stam, D.M.; Rossi, L.C.G.; Rodenhuis, M.; Snik, Frans; Keller, C.U.


    In this work, we analyse linear polarization data of the planet at a distance, obtained with the Extreme Polarimeter (ExPo) on the William Herschel Telescope
    on La Palma. These spatially resolved, high-accuracy polarization observations of Venus show faint circular patterns centered on the

  19. A heat pipe mechanism for volcanism and tectonics on Venus

    International Nuclear Information System (INIS)

    Turcotte, D.L.


    A heat pipe mechanism is proposed for the transport of heat through the lithosphere on Venus. This mechanism allows the crust and lithosphere on Venus to be greater than 150 km thick. A thick crust and thick lithosphere can explain the high observed topography and large associated gravity anomalies. For a 150-km-thick lithosphere the required volcanic flux on Venus is 200 km 3 /yr; this is compared with a flux of 17 km 3 /yr associated with the formation of the oceanic crust on Earth. A thick basaltic crust on Venus is expected to transform to eclogite at a depth of 60 to 80 km; the dense eclogite would contribute the lithospheric delamination that returns the crust to the interior of the planet completing the heat pipe cycle. Topography and the associated gravity anomalies can be explained by Airy compensation of the thick crust. The principal observation that is contrary to this hypothesis is the mean age of the surface that is inferred from crater statistics; the minimum mean age is about 130 Ma, and this implies an upper limit of 2 km 3 /yr for the surface volcanic flux. If the heat pipe mechanism was applicable on Earth in the Archean, it would provide the thick lithosphere implied by isotopic data from diamonds

  20. Distribution of tessera terrain on Venus: Prediction for Magellan

    International Nuclear Information System (INIS)

    Bindschadler, D.L.; Head, J.W.; Kreslavsky, M.A.; Shkuratov, Yu.G.; Ivanov, M.A.; Basilevsky, A.T.


    Tessera terrain is the dominant tectonic unit in the northern hemisphere of Venus and is characterized by complex sets of intersecting structural trends and distinctive radar properties due to a high degree of meter and sub-meter scale (5 cm to 10 m) roughness. Based on these distinctive radar properties, a prediction of the global distribution of tessera can be made using Pioneer Venus (PV) reflectivity and roughness data. Where available, Venera 15/16 and Arecibo images and PV diffuse scattering data were used to evaluate the prediction. From this assessment, the authors conclude that most of the regions with prediction values greater than 0.6 (out of 1) are likely to be tessera, and are almost certain to be tectonically deformed. Lada Terra and Phoebe Regio are very likely to contain tessera terrain, while much of Aphrodite Terra is most likely to be either tessera or a landform which has not yet been recognized on Venus. This prediction map will assist in targeting Magellan investigations of Venus tectonics

  1. Geologic Map of the Helen Planitia Quadrangle (V-52), Venus (United States)

    Lopez, Ivan; Hansen, Vicki L.


    The Magellan spacecraft orbited Venus from August 10, 1990, until it plunged into the Venusian atmosphere on October 12, 1994. Magellan Mission objectives included (1) improving the knowledge of the geological processes, surface properties, and geologic history of Venus by analysis of surface radar characteristics, topography, and morphology and (2) improving the knowledge of the geophysics of Venus by analysis of Venusian gravity. The Helen Planitia quadrangle (V-52), located in the southern hemisphere of Venus between lat 25 deg S. and 50 deg S. and between long 240 deg E. and 270 deg E., covers approximately 8,000,000 km2. Regionally, the map area is located at the southern limit of an area of enhanced tectonomagmatic activity and extensional deformation, marked by a triangle that has highland apexes at Beta, Atla, and Themis Regiones (BAT anomaly) and is connected by the large extensional belts of Devana, Hecate, and Parga Chasmata. The BAT anomaly covers approximately 20 percent of the Venusian surface.

  2. How did Earth not End up like Venus? (United States)

    Jellinek, M.; Lenardic, A.; Weller, M. B.


    Recent geodynamic calculations show that terrestrial planets forming with a chondritic initial bulk composition at order 1 AU can evolve to be either "Earth-like" or "Venus-like": Both mobile- and stagnant-lid tectonic regimes are permitted, neither solution is an explicitly stronger attractor and effects related to differences in Sun-Earth distance are irrelevant. What factors might then cause the thermal evolutionary paths of Earth and Venus to diverge dynamically at early times? At what point in Earth's evolution did plate tectonics emerge and when and how did this tectonic mode gain sufficient resilience to persist over much of Earth's evolution? What is the role of volatile cycling and climate: To what extent have the stable climate of Earth and the greenhouse runaway climate of Venus enforced their distinct tectonic regimes over time? In this talk I will explore some of the mechanisms potentially governing the evolutionary divergence of Earth and Venus. I will first review observational constraints that suggest that Earth's entry into the current stable plate tectonic mode was far from assured by 2 Ga. Next I will discuss how models have been used to build understanding of some key dynamical controls. In particular, the probability of "Earth-like" solutions is affected by: 1) small differences in the initial concentrations of heat producing elements (i.e., planetary initial conditions); 2) long-term climate change; and 3) the character of a planet's early evolutionary path (i.e., tectonic hysteresis).

  3. Runaway greenhouse atmospheres: Applications to Earth and Venus (United States)

    Kasting, James F.


    Runaway greenhouse atmospheres are discussed from a theoretical standpoint and with respect to various practical situation in which they might occur. The following subject areas are covered: (1) runaway greenhouse atmospheres; (2) moist greenhouse atmospheres; (3) loss of water from Venus; (4) steam atmosphere during accretion; and (5) the continuously habitable zone.

  4. Plant Physiology: The Venus Flytrap Counts on Secretion. (United States)

    Brownlee, Colin


    The Venus flytrap effectively detects, traps, digests and absorbs insect prey. A recent study links the mechanical stimulation of sensory hair cells with short- and long-term signalling giving rise to different downstream secretion events that bring about conditions for prey digestion. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Commissioning of the superconducting ECR ion source VENUS

    International Nuclear Information System (INIS)

    Leitner, Daniela; Abbott, Steve R.; Dwinell, Roger D.; Leitner, Matthaeus; Taylor, Clyde; Lyneis, Claude M.


    VENUS (Versatile ECR ion source for NUclear Science) is a next generation superconducting ECR ion source, designed to produce high current, high charge state ions for the 88-Inch Cyclotron at the Lawrence Berkeley National Laboratory. VENUS also serves as the prototype ion source for the RIA (Rare Isotope Accelerator) front end. The magnetic confinement configuration consists of three superconducting axial coils and six superconducting radial coils in a sextupole configuration. The nominal design fields of the axial magnets are 4T at injection and 3T at extraction; the nominal radial design field strength at the plasma chamber wall is 2T, making VENUS the world most powerful ECR plasma confinement structure. The magnetic field strength has been designed for optimum operation at 28 GHz. The four-year VENUS project has recently achieved two major milestones: The first plasma was ignited in June, the first mass-analyzed high charge state ion beam was extracted in September of 2002. The pa per describes the ongoing commissioning. Initial results including first emittance measurements are presented

  6. Runaway greenhouse atmospheres: Applications to Earth and Venus

    International Nuclear Information System (INIS)

    Kasting, J.F.


    Runaway greenhouse atmospheres are discussed from a theoretical standpoint and with respect to various practical situation in which they might occur. The following subject areas are covered: (1) runaway greenhouse atmospheres; (2) moist greenhouse atmospheres; (3) loss of water from Venus; (4) steam atmosphere during accretion; and (5) the continuously habitable zone

  7. Venus näitas lillekleite / Regina Hansen

    Index Scriptorium Estoniae

    Hansen, Regina


    Sunflower Beauty Contest esitles ööklubis Venus eluslilledest valmistatud kleite. Parimaks tunnistati kaupluse Annilill floristid tööga "My Bunny", teiseks tunnistati Katrin Pedaru ja Ninell Soosaare "C'est la vie", kolmanda koha pälvis Karina Saberi töö "Unistus"

  8. Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures

    Directory of Open Access Journals (Sweden)

    Jarline Encarnación-Medina


    Full Text Available ATP-binding cassette subfamily C (ABCC genes code for phase III metabolism proteins that translocate xenobiotic (e.g., particulate matter 2.5 (PM2.5 and drug metabolites outside the cells. IL-6 secretion is related with the activation of the ABCC transporters. This study assesses ABCC1–4 gene expression changes and proinflammatory cytokine (IL-6, IL-8 release in human bronchial epithelial cells (BEAS-2B exposed to PM2.5 organic extract, budesonide (BUD, used to control inflammation in asthmatic patients, and a cotreatment (Co-T: PM2.5 and BUD. A real-time PCR assay shows that ABCC1 was upregulated in BEAS-2B exposed after 6 and 7 hr to PM2.5 extract or BUD but downregulated after 6 hr of the Co-T. ABCC3 was downregulated after 6 hr of BUD and upregulated after 6 hr of the Co-T exposures. ABCC4 was upregulated after 5 hr of PM2.5 extract, BUD, and the Co-T exposures. The cytokine assay revealed an increase in IL-6 release by BEAS-2B exposed after 5 hr to PM2.5 extract, BUD, and the Co-T. At 7 hr, the Co-T decreases IL-6 release and IL-8 at 6 hr. In conclusion, the cotreatment showed an opposite effect on exposed BEAS-2B as compared with BUD. The results suggest an interference of the BUD therapeutic potential by PM2.5.

  9. 3D modeling of lightning-induced electromagnetic pulses on Venus, Jupiter and Saturn (United States)

    Pérez-Invernón, Francisco J.; Luque, Alejandro; Gordillo-Vázquez, Francisco J.


    Atmospheric electricity is a common phenomenon in some planets of The Solar System. We know that atmospheric discharges exist on Earth and gaseous planets; however, some characteristics of lightning on Saturn and Jupiter as well as their relevance on the effects of lightning in the atmospheres of these planets are still unknown. In the case of Venus, there exist some radio evidences of lightning, but the lack of optical observations suggests exploring indirect methods of detection, such as searching for lightning-induced transient optical emissions from the upper atmosphere. The Akatsuki probe, currently orbiting Venus, is equipped with a camera whose temporal resolution is high enough to detect optical emissions from lightning discharges and to measure nightglow enhancements. In this work, we extend previous models [1,2] to investigate the chemical impact and transient optical emissions produced by possible lightning-emitted electromagnetic pulses (EMP) in Venus, Saturn and Jupiter. Using a 3D FDTD ("Finite Differences Time Domain") model we solve the Maxwell equations coupled with the Langevin equation for electrons [3] and with a kinetic scheme, different for each planetary atmosphere. This method is useful to investigate the temporal and spatial impact of lightning-induced electromagnetic fields in the atmosphere of each planet for different lightning characteristics (e.g. energy released, orientation). This 3D FDTD model allows us to include the saturnian and jovian background magnetic field inclination and magnitude at different latitudes, and to determine the effects of different lightning channel inclinations. Results provide useful information to interpret lightning observations on giant gaseous planets and in the search for indirect optical signals from atmospheric discharge on Venus such as fast nightglow transient enhancements related to lightning as seen on Earth. Furthermore, we underline the observation of electrical discharges characteristics as a

  10. Steroid hormone release as well as renal water and electrolyte excretion of mice expressing PKB/SGK-resistant GSK3. (United States)

    Boini, Krishna M; Bhandaru, Madhuri; Mack, Andreas; Lang, Florian


    activity in the regulation of steroid hormone release, renal water and electrolyte excretion and blood pressure control.

  11. Water deprivation increases Fos expression in hypothalamic corticotropin-releasing factor neurons induced by right atrial distension in awake rats. (United States)

    Benedetti, Mauricio; Rorato, Rodrigo; Castro, Margaret; Machado, Benedito H; Antunes-Rodrigues, Jose; Elias, Lucila L K


    Atrial mechanoreceptors, sensitive to stretch, contribute in regulating heart rate and intravascular volume. The information from those receptors reaches the nucleus tractus solitarius and then the paraventricular nucleus (PVN), known to have a crucial role in the regulation of cardiovascular function. Neurons in the PVN synthesize CRF, AVP, and oxytocin (OT). Stimulation of atrial mechanoreceptors was performed in awake rats implanted with a balloon at the junction of the superior vena cava and right atrium. Plasma ACTH, AVP, and OT concentrations and Fos, CRF, AVP, and OT immunolabeling in the PVN were determined after balloon inflation in hydrated and water-deprived rats. The distension of the balloon increased the plasma ACTH concentrations, which were higher in water-deprived than in hydrated rats (P neurons in the parvocellular PVN, which was higher in the water-deprived than in the hydrated group (P neurons after distension in hydrated and water-deprived groups, compared with respective controls. In conclusion, parvocellular CRF neurons showed an increase of Fos expression induced by stimulation of right atrial mechanoreceptors, suggesting that CRF participates in the cardiovascular reflex adjustments elicited by volume loading. Activation of CRF neurons in the PVN by cardiovascular reflex is affected by osmotic stimulation.

  12. Imaging of Gastrin-Releasing Peptide Receptor-Expressing Prostate Tumor using a {sup 68}Ga-Labeled Bombesin Analog

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Jae Cheong; Dho, So Hee; Cho, Eun Ha; Lee, So Young; Kim, Soo Yong [KAERI, Daejeon (Korea, Republic of)


    Although the transmissivity of cold neutrons are low comparing that of thermal neutrons, the slower neutrons are more apt to be absorbed in a target, and can increase the prompt gamma emission rate. Also the flux of both thermal and cold neutron beam is high enough to activate thick target. If the neutron beam is irradiated on the front and the reverse side of gold bar, all insides of it can be detected. The imaging efficacy of {sup 68}Ga-DOTA-gluBBN was evaluated in the PC-3- peritoneal metastasized model. These results suggest that {sup 68}Ga-labeled bombesin derivative has promising characteristics as a novel nuclear medicine, especially for the imaging of GRPR over-expressing prostate tumors. A target for irradiation was produced using 99% Ni-62 metal power concentrate. Ni-62 target of 1 g was irradiated in MARIA reactor operated in Poland for 470 hours at neutron flux of 2.5 x 10{sup 14}n/cm{sup 2}s, and estimated production of Ni-63 was calculated. Irradiated Ni-63 pellets were dissolved in HCl solution, and Ni-63 coatings were deposited by DC electroplating at current density of 20 mA/cm{sup 2}.

  13. Mutual event observations of solar system objects by SRC on Mars Express. Analysis and release of observations (United States)

    Ziese, R.; Willner, K.


    Context. Both Martian moons, Phobos and Deimos, have been observed during several imaging campaigns by the Super Resolution Channel (SRC) on the Mars Express probe. Several tens of images are obtained during mutual event observations - when the Martian moons are both observed or together with another solar system body. These observations provide new opportunities to determine the bodies' positions in their orbits. Aims: A method was sought to automate the observation of the positions of the imaged bodies. Within one image sequence a similarly accurate localization of the objects in all images should be possible. Methods: Shape models of Phobos and Deimos are applied to simulate the appearance of the bodies in the images. Matching the illuminated simulation against the observation provides a reliable determination of the bodies' location within the image. To enhance the matching confidence several corrections need to be applied to the simulation to closely reconstruct the observation. Results: A list of 884 relative positions between the different objects is provided through the Centre de Données astronomiques de Strasbourg (CDS). Tables A.1-A.4 are only available at the CDS via anonymous ftp to ( or via

  14. Combustion-based power source for Venus surface missions (United States)

    Miller, Timothy F.; Paul, Michael V.; Oleson, Steven R.


    The National Research Council has identified in situ exploration of Venus as an important mission for the coming decade of NASA's exploration of our solar system (Squyers, 2013 [1]). Heavy cloud cover makes the use of solar photovoltaics extremely problematic for power generation for Venus surface missions. In this paper, we propose a class of planetary exploration missions (for use on Venus and elsewhere) in solar-deprived situations where photovoltaics cannot be used, batteries do not provide sufficient specific energy and mission duration, and nuclear systems may be too costly or complex to justify or simply unavailable. Metal-fueled, combustion-based powerplants have been demonstrated for application in the terrestrial undersea environment. Modified or extended versions of the undersea-based systems may be appropriate for these sunless missions. We describe systems carrying lithium fuel and sulfur-hexafluoride oxidizer that have the potential for many days of operation in the sunless craters of the moon. On Venus a system level specific energy of 240 to 370 We-hr/kg should be possible if the oxidizer is brought from earth. By using either lithium or a magnesium-based alloy fuel, it may be possible to operate a similar system with CO2 derived directly from the Venus atmosphere, thus providing an estimated system specific energy of 1100 We+PV-hr/kg (the subscript refers to both electrical and mechanical power), thereby providing mission durations that enable useful scientific investigation. The results of an analysis performed by the NASA Glenn COMPASS team describe a mission operating at 2.3 kWe+PV for 5 days (120 h), with less than 260 kg power/energy system mass total. This lander would be of a size and cost suitable for a New Frontiers class of mission.

  15. New perspectives on the accretion and internal evolution of Venus (United States)

    O'Rourke, J. G.


    Dichotomous conditions on Earth and Venus present one of the most compelling mysteries in our Solar System. Ongoing debate centers on how the internal dynamics of Venus have shaped its atmospheric composition, surface features, and even habitability over geologic time. In particular, Venus may have resembled Earth for billions of years before suffering catastrophic transformation, or perhaps some accretionary process set these twin planets on divergent paths from the beginning. Unfortunately, the limited quality of decades-old data—particularly the low resolution of radar imagery and global topography from NASA's Magellan mission—harms our ability to draw definite conclusions. But some progress is possible given recent advances in modeling techniques and improved topography derived from stereo images that are available for roughly twenty percent of the surface. Here I present simulations of the interior evolution of Venus consistent with all available constraints and, more importantly, identify future measurements that would dramatically narrow the range of acceptable scenarios. Obtaining high-resolution imagery and topography, along with any information about the temporal history of a magnetic field, is extremely important. Deformation of geologic features constrains the surface heat flow and lithospheric rheology during their formation. Determining whether craters with radar-dark floors (which comprise 80% of the population) are actually embayed by lava flows would finally settle the controversy over catastrophic versus equilibrium resurfacing. If the core of Venus has completely solidified, then the lack of an internally generated magnetic field today is unsurprising. We might expect dynamo action in the past since relatively high mantle temperatures may increase the rate of core cooling—unless a lack of giant impacts during accretion permitted chemical stratification that resists convection. In any case, uncertainty about our celestial cousin reveals a

  16. Geologic map of the Ganiki Planitia quadrangle (V-14), Venus (United States)

    Grosfils, Eric B.; Long, Sylvan M.; Venechuk, Elizabeth M.; Hurwitz, Debra M.; Richards, Joseph W.; Drury, Dorothy E.; Hardin, Johanna


    Vinmara Planitia), a geologic map of the region may yield insight into a wide array of important problems in Venusian geology. The current mapping effort and analysis complements previous efforts to characterize aspects of the region’s geology, for example stratigraphy near parabolic halo crater sites, volcanic plains emplacement, wrinkle ridges, volcanic feature distribution, volcano deformation, coronae characteristics, lithospheric flexure, and various features along a 30±7.58° N. geotraverse. Our current research focuses on addressing four specific questions. Has the dominant style of volcanic expression within the quadrangle varied in a systematic fashion over time? Does the tectonic deformation within the quadrangle record significant regional patterns that vary spatially or temporally, and if so what are the scales, orientations and sources of the stress fields driving this deformation? If mantle upwelling and downwelling have played a significant role in the formation of Atla Regio and Atalanta Planitia as has been proposed, does the geology of Ganiki Planitia record evidence of northwest-directed lateral mantle flow connecting the two sites? Finally, can integration of the tectonic and volcanic histories preserved within the quadrangle help constrain competing resurfacing models for Venus?

  17. Expression

    Directory of Open Access Journals (Sweden)

    Wang-Xia Wang


    Full Text Available The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs, sharing a 5′ AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members, and other selected miRNAs, in 11 human tissues obtained at autopsy including the cerebral cortex, frontal cortex, primary visual cortex, thalamus, heart, lung, liver, kidney, spleen, stomach and skeletal muscle. miR-103, miR-195 and miR-497 were expressed at similar levels across various tissues, whereas miR-107 is enriched in brain samples. We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations (enriched for cortical neurons, astrocytes and microglia, respectively. In primary cultures of rat brain cells, several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system (CNS. In addition to mature miRNAs, we also examined the expression of precursors (pri-miRNAs. Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors. In summary, we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.

  18. Enhanced cellular immune response against SIV Gag induced by immunization with DNA vaccines expressing assembly and release-defective SIV Gag proteins

    International Nuclear Information System (INIS)

    Bu Zhigao; Ye Ling; Compans, Richard W.; Yang Chinglai


    Codon-optimized genes were synthesized for the SIVmac239 Gag, a mutant Gag with mutations in the major homology region, and a chimeric Gag containing a protein destruction signal at the N-terminus of Gag. The mutant and chimeric Gag were expressed at levels comparable to that observed for the wild-type Gag protein but their stability and release into the medium were found to be significantly reduced. Immunization of mice with DNA vectors encoding the mutant or chimeric Gag induced fourfold higher levels of anti-SIV Gag CD4 T cell responses than the DNA vector encoding the wild-type SIV Gag. Moreover, anti-SIV Gag CD8 T cell responses induced by DNA vectors encoding the mutant or chimeric Gag were found to be 5- to 10-fold higher than those induced by the DNA construct for the wild-type Gag. These results indicate that mutations disrupting assembly and/or stability of the SIV Gag protein effectively enhance its immunogenicity when expressed from DNA vaccines

  19. Effect of Puumala hantavirus infection on Human Umbilical Vein Endothelial Cell hemostatic function: platelet interactions, increased tissue factor expression and fibrinolysis regulator release

    Directory of Open Access Journals (Sweden)

    Marco Goeijenbier


    Full Text Available Puumala virus (PUUV infection causes over 5000 cases of hemorrhagic fever in Europe annually and can influence the hemostatic balance extensively. Infection might lead to hemorrhage, while a recent study showed an increased risk of myocardial infarction during or shortly after PUUV infection. The mechanism by which this hantavirus influences the coagulation system remains unknown. Therefore we aimed to elucidate mechanisms explaining alterations seen in primary and secondary hemostasis during PUUV infection. By using low passage PUUV isolates to infect primary human umbilical vein endothelial cells (HUVECs we were able to show alterations in the regulation of primary- and secondary hemostasis and in the release of fibrinolysis regulators. Our main finding was an activation of secondary hemostasis due to increased tissue factor expression leading to increased thrombin generation in a functional assay. Furthermore, we showed that during infection platelets adhered to HUVECs and subsequently specifically to PUUV virus particles. Infection of HUVECs with PUUV did not result in increased von Willebrand factor while they produced more plasminogen activator inhibitor type-1 (PAI-1 compared to controls. The PAI-1 produced in this model formed complexes with vitronectin. This is the first report that reveals a potential mechanism behind the pro-coagulant changes in PUUV patients, which could be the result of increased thrombin generation due to an increased tissue factor expression on endothelial cells during infection. Furthermore, we provide insight into the contribution of endothelial cell responses regarding hemostasis in PUUV pathogenesis.

  20. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. (United States)

    McCarrel, Taralyn; Fortier, Lisa


    Platelet-rich plasma (PRP) has generated substantial interest for tendon and ligament regeneration because of the high concentrations of growth factors in platelet alpha-granules. This study compared the temporal release of growth factors from bone marrow aspirate (BMA), PRP, and lyophilized platelet product (PP), and measured their effects on tendon and ligament gene expression. Blood and BMA were collected and processed to yield PRP and plasma. Flexor digitorum superficialis tendon (FDS) and suspensory ligament (SL) explants were cultured in 10% plasma in DMEM (control), BMA, PRP, or PP. TGF-beta1 and PDGF-BB concentrations were determined at 0, 24, and 96 h of culture using ELISA. Quantitative RT-PCR for collagen types I and III (COL1A1, COL3A1), cartilage oligomeric matrix protein (COMP), decorin, and matrix metalloproteinases-3 and 13 (MMP-3, MMP-13) was performed. TGF-beta1 and PDGF-BB concentrations were highest in PRP and PP. Growth factor quantity was unchanged in BMA, increased in PRP, and decreased in PP over 4 days. TGF-beta1 and platelet concentrations were positively correlated. Lyophilized PP and PRP resulted in increased COL1A1:COL3A1 ratio, increased COMP, and decreased MMP-13 expression. BMA resulted in decreased COMP and increased MMP-3 and MMP-13 gene expression. Platelet concentration was positively correlated with COL1A1, ratio of COL1A1:COL3A1, and COMP, and negatively correlated with COL3A1, MMP-13, and MMP-3. White blood cell concentration was positively correlated with COL3A1, MMP3, and MMP13, and negatively correlated with a ratio of COL1A1:COL3A1, COMP, and decorin. These findings support further in vivo investigation of PRP and PP for treatment of tendonitis and desmitis. Copyright 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  1. Expression and distribution of octopus gonadotropin-releasing hormone in the central nervous system and peripheral organs of the octopus (Octopus vulgaris) by in situ hybridization and immunohistochemistry. (United States)

    Iwakoshi-Ukena, Eiko; Ukena, Kazuyoshi; Takuwa-Kuroda, Kyoko; Kanda, Atshuhiro; Tsutsui, Kazuyoshi; Minakata, Hiroyuki


    We recently purified a peptide with structural features similar to vertebrate gonadotropin-releasing hormone (GnRH) from the brain of Octopus vulgaris, cloned a cDNA encoding the precursor protein, and named it oct-GnRH. In the current study, we investigated the expression and distribution of oct-GnRH throughout the central nervous system (CNS) and peripheral organs of Octopus by in situ hybridization on the basis of the cDNA sequence and by immunohistochemistry using a specific antiserum against oct-GnRH. Oct-GnRH mRNA-expressing cell bodies were located in 10 of 19 lobes in the supraesophageal and subesophageal parts of the CNS. Several oct-GnRH-like immunoreactive fibers were seen in all the neuropils of the CNS lobes. The sites of oct-GnRH mRNA expression and the mature peptide distribution were consistent with each other as judged by in situ hybridization and immunohistochemistry. In addition, many immunoreactive fibers were distributed in peripheral organs such as the heart, the oviduct, and the oviducal gland. Modulatory effects of oct-GnRH on the contractions of the heart and the oviduct were demonstrated. The results suggested that, in the context of reproduction, oct-GnRH is a key peptide in the subpedunculate lobe and/or posterior olfactory lobe-optic gland-gonadal axis, an octopus analogue of the hypothalamo-hypophysial-gonadal axis. It may also act as a modulatory factor in controlling higher brain functions such as feeding, memory, movement, maturation, and autonomic functions

  2. Comparison of dayside current layers in Venus' ionosphere and earth's equatorial electrojet (United States)

    Cole, Keith D.


    The major physical aspects of the equatorial electrojet of Earth and the dayside ionospheric current layers of Venus are compared, viz., the electric current intensity and total current, roles of electric field, pressure and gravity, diffusion time scales, and the Bernouille effect. The largest potential differences, of the order of 10 volts, horizontally across the dayside ionosphere of Venus, have important implications for possible dynamo action in the Venus ionosphere and the application of an electric field from the lower atmosphere or from the solar wind. An upper limit to the horizontal scale of vertical magnetic fields in the Venus ionosphere is estimated thereby for the first time. New upper limits on the velocity in, and thickness of, a possible S layer at Venus are presented. If an S layer exists, it is only for extreme conditions of the solar wind. A mechanism for formation of magnetic ropes in the Venus ionosphere is also proposed.

  3. Non-Cooled Power System for Venus Lander (United States)

    Salazar, Denise; Landis, Geoffrey A.; Colozza, Anthony J.


    The Planetary Science Decadal Survey of 2013-2022 stated that the exploration of Venus is of significant interest. Studying the seismic activity of the planet is of particular importance because the findings can be compared to the seismic activity of Earth. Further, the geological and atmospheric properties of Venus will shed light into the past and future of Earth. This paper presents a radioisotope power system (RPS) design for a small low-power Venus lander. The feasibility of the new power system is then compared to that of primary batteries. A requirement for the power source system is to avoid moving parts in order to not interfere with the primary objective of the mission - to collect data about the seismic activity of Venus using a seismometer. The target mission duration of the lander is 117 days, a significant leap from Venera 13, the longest-lived lander on the surface of Venus, which survived for 2 hours. One major assumption for this mission design is that the power source system will not provide cooling to the other components of the lander. This assumption is based on high-temperature electronics technology that will enable the electronics and components of the lander to operate at Venus surface temperature. For the proposed RPS, a customized General Purpose Heat Source Radioisotope Thermoelectric Generator (GPHSRTG) is designed and analyzed. The GPHS-RTG is chosen primarily because it has no moving parts and it is capable of operating for long duration missions on the order of years. This power system is modeled as a spherical structure for a fundamental thermal analysis. The total mass and electrical output of the system are calculated to be 24 kilograms and 26 Watts, respectively. An alternative design for a battery-based power system uses Sodium Sulfur batteries. To deliver a similar electrical output for 117 days, the battery mass is calculated to be 234 kilograms. Reducing mission duration or power required will reduce the required battery mass

  4. Asteroids and Meteorites from Venus? Only the Earth Goddess Knows (United States)

    Dones, Henry; Zahnle, Kevin J.; Alvarellos, José L.


    No meteorites from Venus have been found; indeed, some find theirexistence unlikely because of the perceived difficulty of launchingrocks at speeds above 10 km/s and traversing the planet's 93 baratmosphere. [1] Nonetheless, we keep hope alive, since cosmochemistssay they can identify Cytherean meteorites, should candidates be found[2]. Gladman et al. [3] modeled the exchange of impact ejecta betweenthe terrestrial planets, but did not consider meteorites launched fromVenus in any detail. At the time of Gladman's work, no asteroids thatremained entirely within Earth's orbit were known. 14 suchEarth-interior objects with good orbits have now been discovered, andare known as Atiras, for the Pawnee goddess of the Earth. The largestknown member of the class is 163693 Atira, a binary whose componentshave diameters of approximately 4.8 and 1 km. Discovery of Atiras isvery incomplete because they can only be seen at small solarelongations [4]. Greenstreet et al. [5] modeled the orbitaldistribution of Atiras from main-belt asteroidal and cometary sourceregions, while Ribeiro et al. [6] mapped the stability region ofhypothetical Atiras and integrated the orbits of clones of 12 realAtiras for 1 million years. 97% of the clones survived for 1 Myrimpact with Venus was the most common fate of those that met theirends. We have performed orbital integrations of 1000 clones of each ofthe known Atiras, and of hypothetical ejecta that escape Venus afterasteroid impacts, for 10-100 Myr. The latter calculations usetechniques like those of Alvarellos et al. [7] and Zahnle et al. [8]for transfer amongst Jupiter's galilean satellites. Our goals are toestimate the fraction of Atiras that are ejecta launched from Venus,the time spent in space by hypothetical meteorites from Venus, and therate at which such meteorites strike the Earth.[1] Gilmore M., et al (2017). Space Sci. Rev. 212, 1511. [2] JourdanF., Eroglu E. (2017). MAPS 52, 884. [3] Gladman B.J., etal. (1996). Science 271, 1387. [4

  5. VENUS+δf - A bootstrap current calculation module for 3D configurations

    International Nuclear Information System (INIS)

    Isaev, M.Yu.; Brunner, S.; Cooper, W.A.; Tran, T.M.; Bergmann, A.; Beidler, C.D.; Geiger, J.; Maassberg, H.; Nuehrenberg, J.; Schmidt, M.


    We present a new 3D code VENUS+δf for neoclassical transport calculations in nonaxisymmetric toroidal systems. Numerical drift orbits from the original VENUS code and the δf method for tokamak transport calculations are combined. The first results obtained with VENUS+δf are compared with neoclassical theory for different collisional regimes in a JT-60 tokamak test case with monoenergetic particles and with a Maxwellian distribution. Benchmarks with DKES code results for the bootstrap current in the W7X configuration as well as further VENUS+δf developments are discussed. (author)

  6. Earthlike planets: Surfaces of Mercury, Venus, earth, moon, Mars (United States)

    Murray, B.; Malin, M. C.; Greeley, R.


    The surfaces of the earth and the other terrestrial planets of the inner solar system are reviewed in light of the results of recent planetary explorations. Past and current views of the origin of the earth, moon, Mercury, Venus and Mars are discussed, and the surface features characteristic of the moon, Mercury, Mars and Venus are outlined. Mechanisms for the modification of planetary surfaces by external factors and from within the planet are examined, including surface cycles, meteoritic impact, gravity, wind, plate tectonics, volcanism and crustal deformation. The origin and evolution of the moon are discussed on the basis of the Apollo results, and current knowledge of Mercury and Mars is examined in detail. Finally, the middle periods in the history of the terrestrial planets are compared, and future prospects for the exploration of the inner planets as well as other rocky bodies in the solar system are discussed.

  7. Mantle differentiation and thermal evolution of Mars, Mercury, and Venus

    International Nuclear Information System (INIS)

    Spohn, T.


    In the present models for the thermal evolution of Mercury, Venus, and Mars encompass core and mantle chemical differentiation, lithospheric growth, and volcanic heat-transfer processes. Calculation results indicate that crust and lithosphere thicknesses are primarily dependent on planet size as well as the bulk concentration of planetary radiogenic elements and the lithosphere's thermal conductivity. The evidence for Martian volcanism for at least 3.5 Gyr, and in Mercury for up to 1 Gyr, in conjunction with the presence of a magnetic field on Mercury and its absence on Mars, suggest the dominance of a lithospheric conduction heat-transfer mechanism in these planets for most of their thermal history; by contrast, volcanic heat piping may have been an important heat-transfer mechanism on Venus. 50 refs

  8. Venus spherical harmonic gravity model to degree and order 60 (United States)

    Konopliv, Alex S.; Sjogren, William L.


    The Magellan and Pioneer Venus Orbiter radiometric tracking data sets have been combined to produce a 60th degree and order spherical harmonic gravity field. The Magellan data include the high-precision X-band gravity tracking from September 1992 to May 1993 and post-aerobraking data up to January 5, 1994. Gravity models are presented from the application of Kaula's power rule for Venus and an alternative a priori method using surface accelerations. Results are given as vertical gravity acceleration at the reference surface, geoid, vertical Bouguer, and vertical isostatic maps with errors for the vertical gravity and geoid maps included. Correlation of the gravity with topography for the different models is also discussed.

  9. Nuclear Electric Propulsion Application: RASC Mission Robotic Exploration of Venus (United States)

    McGuire, Melissa L.; Borowski, Stanley K.; Packard, Thomas W.


    The following paper documents the mission and systems analysis portion of a study in which Nuclear Electric Propulsion (NEP) is used as the in-space transportation system to send a series of robotic rovers and atmospheric science airplanes to Venus in the 2020 to 2030 timeframe. As part of the NASA RASC (Revolutionary Aerospace Systems Concepts) program, this mission analysis is meant to identify future technologies and their application to far reaching NASA missions. The NEP systems and mission analysis is based largely on current technology state of the art assumptions. This study looks specifically at the performance of the NEP transfer stage when sending a series of different payload package point design options to Venus orbit.

  10. Pioneer Venus Star Sensor. [active despin control application (United States)

    Gutshall, R. L.; Thomas, G.


    The design predictions and orbital performance verification of the solid state star scanner used in the Onboard Attitude Control of the Pioneer Venus Orbiter and Multiprobe are presented. The star sensor extended the scanner use to active despin control, and it differs from previous sensors in solid state detection, redundant electronics for reliability, larger field of view, and large dynamic spin range. The star scanner hardware and design performance based on the ability to predict all noise sources, signal magnitudes, and expected detection probability are discussed. In-flight data collected to verify sensor ground calibration are tabulated and plotted in predicted accuracy curves. It is concluded that the Pioneer Venus Star Sensor has demonstrated predictable star calibration in the range of .1 magnitude uncertainties and usable star catalogs of 100 stars with very high probabilities of detection, which were much better than expected and well within the mission requirements.

  11. Oxides of nitrogen and the clouds of Venus

    International Nuclear Information System (INIS)

    Watson, A.J.; Donahue, T.M.; Stedman, D.H.; Knollenberg, R.G.; Ragent, B.; Blamont, J.


    Nitric Oxide may be produced in the atmosphere of Venus by lightning storms in the clouds. Here we suggest that the odd nitrogen thus formed may play an important part in the chemistry of the clouds. Specifically, we estimate production rates for NO 2 in the limiting case of high NO concentrations. If the NO density is high we suggest that NO 2 may catalyse the production of sulfuric acid aerosol from sulfur dioxide and water vapor, and may also form nitrogen--sulfur compounds such as nitrosyl sulfuric acid, NOHSO 4 . The ''large particles'' seen by the Pioneer Venus sounder probe may contain considerable quantities of NOHSO 4 . If this is the case odd nitrogen must be present in the atmosphere in at least a parts-per-million mixing ratio

  12. Parquet: Regions of areal plastic dislocations (on Venus) (United States)

    Sukhanov, A. L.


    The extensive flat elevations of the Northern Hemisphere of Venus are covered with frequently intersecting lines of dislocations, resembling the outline of a giant parquet. In the internal sections of these regions we find grabens and regions of extension, and on the periphery lobe-shaped flow structures. The parquet was formed after the beginning of the formation of the lava plains, but covered by the youngest lava. These structures apparently arose partly because of the dragging of blocks of crust by the asthenospheric flows, and partly in the gravitational sliding of such heated blocks in the partial melting of their base. It is possible that these elevations occupy on Venus the place of the Earth's rift systems.

  13. Preliminary radar systems analysis for Venus orbiter missions (United States)

    Brandenburg, R. K.; Spadoni, D. J.


    A short, preliminary analysis is presented of the problems involved in mapping the surface of Venus with radar from an orbiting spacecraft. Two types of radar, the noncoherent sidelooking and the focused synthetic aperture systems, are sized to fulfill two assumed levels of Venus exploration. The two exploration levels, regional and local, assumed for this study are based on previous Astro Sciences work (Klopp 1969). The regional level is defined as 1 to 3 kilometer spatial and 0.5 to 1 km vertical resolution of 100 percent 0 of the planet's surface. The local level is defined as 100 to 200 meter spatial and 50-10 m vertical resolution of about 100 percent of the surfAce (based on the regional survey). A 10cm operating frequency was chosen for both radar systems in order to minimize the antenna size and maximize the apparent radar cross section of the surface.

  14. Parabolic features and the erosion rate on Venus (United States)

    Strom, Robert G.


    The impact cratering record on Venus consists of 919 craters covering 98 percent of the surface. These craters are remarkably well preserved, and most show pristine structures including fresh ejecta blankets. Only 35 craters (3.8 percent) have had their ejecta blankets embayed by lava and most of these occur in the Atla-Beta Regio region; an area thought to be recently active. parabolic features are associated with 66 of the 919 craters. These craters range in size from 6 to 105 km diameter. The parabolic features are thought to be the result of the deposition of fine-grained ejecta by winds in the dense venusian atmosphere. The deposits cover about 9 percent of the surface and none appear to be embayed by younger volcanic materials. However, there appears to be a paucity of these deposits in the Atla-Beta Regio region, and this may be due to the more recent volcanism in this area of Venus. Since parabolic features are probably fine-grain, wind-deposited ejecta, then all impact craters on Venus probably had these deposits at some time in the past. The older deposits have probably been either eroded or buried by eolian processes. Therefore, the present population of these features is probably associated with the most recent impact craters on the planet. Furthermore, the size/frequency distribution of craters with parabolic features is virtually identical to that of the total crater population. This suggests that there has been little loss of small parabolic features compared to large ones, otherwise there should be a significant and systematic paucity of craters with parabolic features with decreasing size compared to the total crater population. Whatever is erasing the parabolic features apparently does so uniformly regardless of the areal extent of the deposit. The lifetime of parabolic features and the eolian erosion rate on Venus can be estimated from the average age of the surface and the present population of parabolic features.

  15. Geological map of the Kaiwan Fluctus Quadrangle (V-44), Venus (United States)

    Bridges, Nathan T.; McGill, George E.


    Introduction The Magellan spacecraft orbited Venus from August 10, 1990, until it plunged into the Venusian atmosphereon October 12, 1994. Magellan had the objectives of: (1) improving knowledge of the geologic processes, surface properties, and geologic history of Venus by analysis of surface radar characteristics, topography, and morphology and (2) improving knowledge of the geophysics of Venus by analysis of Venusian gravity. The Magellan spacecraft carried a 12.6-cm radar system to map the surface of Venus. The transmitter and receiver systems were used to collect three datasets: synthetic aperture radar (SAR) images of the surface, passive microwave thermal emission observations, and measurements of the backscattered power at small angles of incidence, which were processed to yield altimetric data. Radar imaging and altimetric and radiometric mapping of the Venusian surface were done in mission cycles 1, 2, and 3, from September 1990 until September of 1992. Ninety-eight percent of the surface was mapped with radar resolution of approximately 120 meters. The SAR observations were projected to a 75-m nominal horizontal resolution; these full-resolution data compose the image base used in geologic mapping. The primary polarization mode was horizontal-transmit, horizontal receive (HH), but additional data for selected areas were collected for the vertical polarization sense. Incidence angles varied from about 20? to 45?. High-resolution Doppler tracking of the spacecraft was done from September 1992 through October 1994 (mission cycles 4, 5, 6). High-resolution gravity observations from about 950 orbits were obtained between September 1992 and May 1993, while Magellan was in an elliptical orbit with a periapsis near 175 kilometers and an apoapsis near 8,000 kilometers. Observations from an additional 1,500 orbits were obtained following orbit-circularization in mid-1993. These data exist as a 75? by 75? harmonic field.

  16. Geologic Map of the Mylitta Fluctus Quadrangle (V-61), Venus (United States)

    Ivanov, Mikhail A.; Head, James W.


    INTRODUCTION The Magellan Mission The Magellan spacecraft orbited Venus from August 10, 1990, until it plunged into the Venusian atmosphere on October 12, 1994. Magellan Mission objectives included: (1) improving knowledge of the geological processes, surface properties, and geologic history of Venus by analysis of surface radar characteristics, topography, and morphology, and (2) improving the knowledge of the geophysics of Venus by analysis of Venusian gravity. The Magellan spacecraft carried a 12.6-cm radar system to map the surface of Venus. The transmitter and receiver systems were used to collect three data sets: (1) synthetic aperture radar (SAR) images of the surface, (2) passive microwave thermal emission observations, and (3) measurements of the backscattered power at small angles of incidence, which were processed to yield altimetric data. Radar imaging, altimetric, and radiometric mapping of the Venusian surface was done in mission cycles 1, 2, and 3 from September 1990 until September 1992. Ninety-eight percent of the surface was mapped with radar resolution on the order of 120 meters. The SAR observations were projected to a 75-m nominal horizontal resolution, and these full-resolution data compose the image base used in geologic mapping. The primary polarization mode was horizontal-transmit, horizontal-receive (HH), but additional data for selected areas were collected for the vertical polarization sense. Incidence angles varied between about 20? and 45?. High resolution Doppler tracking of the spacecraft took place from September 1992 through October 1994 (mission cycles 4, 5, 6). Approximately 950 orbits of high-resolution gravity observations were obtained between September 1992 and May 1993 while Magellan was in an elliptical orbit with a periapsis near 175 km and an apoapsis near 8,000 km. An additional 1,500 orbits were obtained following orbit-circularization in mid-1993. These data exist as a 75? by 75? harmonic field.

  17. Geologic map of the Pandrosos Dorsa Quadrangle (V-5), Venus (United States)

    Rosenberg, Elizabeth; McGill, George E.


    Introduction The Magellan spacecraft orbited Venus from August 10, 1990, until it plunged into the Venusian atmosphere on October 12, 1994. Magellan had the objectives of (1) improving knowledge of the geologic processes, surface properties, and geologic history of Venus by analysis of surface radar characteristics, topography, and morphology and (2) improving knowledge of the geophysics of Venus by analysis of Venusian gravity. The Magellan spacecraft carried a 12.6-cm radar system to map the surface of Venus. The transmitter and receiver systems were used to collect three datasets: synthetic aperture radar (SAR) images of the surface, passive microwave thermal emission observations, and measurements of the backscattered power at small angles of incidence, which were processed to yield altimetric data. Radar imaging and altimetric and radiometric mapping of the Venusian surface were done in mission cycles 1, 2, and 3, from September 1990 until September 1992. Ninety-eight percent of the surface was mapped with radar resolution of approximately 120 meters. The SAR observations were projected to a 75-m nominal horizontal resolution; these full-resolution data compose the image base used in geologic mapping. The primary polarization mode was horizontal-transmit, horizontal-receive (HH), but additional data for selected areas were collected for the vertical polarization sense. Incidence angles varied from about 20? to 45?. High-resolution Doppler tracking of the spacecraft was done from September 1992 through October 1994 (mission cycles 4, 5, 6). High-resolution gravity observations from about 950 orbits were obtained between September 1992 and May 1993, while Magellan was in an elliptical orbit with a periapsis near 175 kilometers and an apoapsis near 8,000 kilometers. Observations from an additional 1,500 orbits were obtained following orbitcircularization in mid-1993. These data exist as a 75? by 75? harmonic field.

  18. Magma Reservoirs Feeding Giant Radiating Dike Swarms: Insights from Venus (United States)

    Grosfils, E. B.; Ernst, R. E.


    Evidence of lateral dike propagation from shallow magma reservoirs is quite common on the terrestrial planets, and examination of the giant radiating dike swarm population on Venus continues to provide new insight into the way these complex magmatic systems form and evolve. For example, it is becoming clear that many swarms are an amalgamation of multiple discrete phases of dike intrusion. This is not surprising in and of itself, as on Earth there is clear evidence that formation of both magma reservoirs and individual giant radiating dikes often involves periodic magma injection. Similarly, giant radiating swarms on Earth can contain temporally discrete subswarms defined on the basis of geometry, crosscutting relationships, and geochemical or paleomagnetic signatures. The Venus data are important, however, because erosion, sedimentation, plate tectonic disruption, etc. on Earth have destroyed most giant radiating dike swarm's source regions, and thus we remain uncertain about the geometry and temporal evolution of the magma sources from which the dikes are fed. Are the reservoirs which feed the dikes large or small, and what are the implications for how the dikes themselves form? Does each subswarm originate from a single, periodically reactivated reservoir, or do subswarms emerge from multiple discrete geographic foci? If the latter, are these discrete foci located at the margins of a single large magma body, or do multiple smaller reservoirs define the character of the magmatic center as a whole? Similarly, does the locus of magmatic activity change with time, or are all the foci active simultaneously? Careful study of giant radiating dike swarms on Venus is yielding the data necessary to address these questions and constrain future modeling efforts. Here, using giant radiating dike swarms from the Nemesis Tessera (V14) and Carson (V43) quadrangles as examples, we illustrate some of the dike swarm focal region diversity observed on Venus and briefly explore some

  19. Noise stress changes mRNA expressions of corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors

    Directory of Open Access Journals (Sweden)

    Evren Eraslan


    Full Text Available Noise is a psychological, environmental stressor that activates limbic sites in the brain. Limbic sites such as the amygdala and the amygdaloid corticotropin-releasing hormone (CRH system play an important role in integrating stress response. We investigated the association between noise exposures, CRH-related molecules in the amygdala, and behavioral alterations. In total 54 Sprague-Dawley rats were divided into the following three groups: Control (CON, acute noise exposure (ANE, and chronic noise exposure (CNE. The ANE group was exposed to 100 dB white noise only once in 4 h and the CNE group was exposed to the same for 4 h per day for 30 days. Expression profiles of CRH and its receptors CRH-R1 and CRH-R2 were analyzed by quantitative real-time polymerase chain reaction (qPCR. The same stress procedure was applied to the ANE and CNE groups for behavior testing. The anxiety responses of the animals after acute and chronic stress exposure were measured in the defensive withdrawal test. CNE upregulated CRH and CRH-R1 mRNA levels but downregulated CRH-R2 mRNA levels. ANE led to a decrease in both CRH-R1 and CRH-R2 expression. In the defensive withdrawal test, while the ANE increased, CNE reduced anxiety-like behaviors. The present study shows that the exposure of rats to white noise (100 dB leads to behavioral alterations and molecule-specific changes in the CRH system. Behavioral alterations can be related to these molecular changes in the amygdala.

  20. Noise stress changes mRNA expressions of corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors. (United States)

    Eraslan, Evren; Akyazi, Ibrahim; Erg L-Ekiz, Elif; Matur, Erdal


    Noise is a psychological, environmental stressor that activates limbic sites in the brain. Limbic sites such as the amygdala and the amygdaloid corticotropin-releasing hormone (CRH) system play an important role in integrating stress response. We investigated the association between noise exposures, CRH-related molecules in the amygdala, and behavioral alterations. In total 54 Sprague-Dawley rats were divided into the following three groups: Control (CON), acute noise exposure (ANE), and chronic noise exposure (CNE). The ANE group was exposed to 100 dB white noise only once in 4 h and the CNE group was exposed to the same for 4 h per day for 30 days. Expression profiles of CRH and its receptors CRH-R1 and CRH-R2 were analyzed by quantitative real-time polymerase chain reaction (qPCR). The same stress procedure was applied to the ANE and CNE groups for behavior testing. The anxiety responses of the animals after acute and chronic stress exposure were measured in the defensive withdrawal test. CNE upregulated CRH and CRH-R1 mRNA levels but downregulated CRH-R2 mRNA levels. ANE led to a decrease in both CRH-R1 and CRH-R2 expression. In the defensive withdrawal test, while the ANE increased, CNE reduced anxiety-like behaviors. The present study shows that the exposure of rats to white noise (100 dB) leads to behavioral alterations and molecule-specific changes in the CRH system. Behavioral alterations can be related to these molecular changes in the amygdala.

  1. Elastic Thickness Estimates for Coronae Associated with Chasmata on Venus (United States)

    Hoogenboom, T.; Martin, P.; Housean, G. A.


    Coronae are large-scale circular tectonic features surrounded by annular ridges. They are generally considered unique to Venus and may offer insights into the differences in lithospheric structure or mantle convective pattern between Venus and Earth. 68% of all coronae are associated with chasmata or fracture belts. The remaining 32% are located at volcanic rises or in the plains. Chasmata are linear to arcuate troughs, with trough parallel fractures and faults which extend for 1000 s of kilometers. Estimates of the elastic thickness of the lithosphere (T(sub e)) have been calculated in a number of gravity/topography studies of Venus and for coronae specifically. None of these studies, however, have explored the dependence of T(sub e) on the tectonic history of the region, as implied from the interpretation of relative timing relationships between coronae and surrounding features. We examine the relationship between the local T(sub e) and the relative ages of coronae and chasmata with the aim of further constraining the origin and evolution of coronae and chasmata systems.

  2. Magellan: A new view of Venus' geology and geophysics (United States)

    Bindschadler, D. L.


    Within the past fifteen years, the surface of Venus has gone from being the least well understood of all the terrestrial planets to the most thoroughly mapped surface of any terrestrial planet, including the Earth. This is primarily due to the Magellan mission, which has collected a variety of data on the surface morphology, physical properties, and interior density structure of Venus amounting to more than 1 Terabit (1012 bits) of data. Synthetic aperture radar images have been obtained for over 95% of the surface; their high resolution reveals most surface features larger than 100-200 meters across. Using its radar altimeter, Magellan has collected data on surface elevations, sub-meter scale roughness, and radar reflectivity at a resolution of approximately 10 km. Further information on the physical properties of the surface was gathered by measuring the passive microwave emissivity of the surface [Pettengill et al, 1992]. Two-way Doppler tracking of the spacecraft has yielded line-of-sight (LOS) gravity data and a spherical harmonic model of gravity and geoid out to degree 75. Collection of high-resolution gravity data has been aided by an innovative aerobraking maneuver, which used Venus' atmosphere to brake the spacecraft and lower it from a highly elliptical orbit to a near-circular orbit.

  3. A high resolution gravity model for Venus - GVM-1 (United States)

    Nerem, R. S.; Bills, B. G.; Mcnamee, J. B.


    A spherical harmonic model of the gravitational field of Venus complete to degree and order 50 has been developed using the S-band Doppler tracking data of the Pioneer Venus Orbiter (PVO) collected between 1979 and 1982. The short wavelengths of this model could only be resolved near the PVO periapse location (about 14 deg N latitude), therefore a priori constraints were applied to the model to bias poorly observed coefficients towards zero. The resulting model has a half-wavelength resolution of 400 km near the PVO periapse location, but the resolution degrades to greater than 1000 km near the poles. This gravity model correlates well with a degree 50 spherical harmonic expansion of the Venus topography derived from a combination of Magellan and PVO data. New tracking data from Magellan's gravity mission should provide some improvement to this model, although a complete model of the Venusian gravity field will depend on tracking of Magellan after the circularization of its orbit using aerobraking.

  4. Submarine Volcanic Eruptions and Potential Analogs for Venus (United States)

    Wilson, L.; Mouginismark, P. J.; Fryer, P.; Gaddis, L. R.


    As part of an analysis program to better understand the diversity of volcanic processes on the terrestrial planets, an investigation of the volcanic landforms which exist on the Earth's ocean floor was initiated. In part, this analysis is focused toward gaining a better understanding of submarine volcanic landforms in their own right, but also it is hoped that these features may show similarities to volcanic landforms on Venus, due to the high ambient water (Earth) and atmospheric (Venus) pressures. A series of numerical modelling experiments was performed to investigate the relative importance of such attributes as water pressure and temperature on the eruption process, and to determine the rate of cooling and emplacement of lava flows in the submarine environment. Investigations to date show that the confining water pressure and the buoyancy effects of the surrounding water significantly affect the styles of volcanism on the ocean floor. In the case of Venusian volcanism, confining pressures will not be as great as that found at the ocean's abyssal plains, but nevertheless the general trend toward reducing magma vesiculation will hold true for Venus as well as the ocean floor. Furthermore, other analogs may also be found between submarine volcanism and Venusian activity.

  5. Near-infrared oxygen airglow from the Venus nightside (United States)

    Crisp, D.; Meadows, V. S.; Allen, D. A.; Bezard, B.; Debergh, C.; Maillard, J.-P.


    Groundbased imaging and spectroscopic observations of Venus reveal intense near-infrared oxygen airglow emission from the upper atmosphere and provide new constraints on the oxygen photochemistry and dynamics near the mesopause (approximately 100 km). Atomic oxygen is produced by the Photolysis of CO2 on the dayside of Venus. These atoms are transported by the general circulation, and eventually recombine to form molecular oxygen. Because this recombination reaction is exothermic, many of these molecules are created in an excited state known as O2(delta-1). The airglow is produced as these molecules emit a photon and return to their ground state. New imaging and spectroscopic observations acquired during the summer and fall of 1991 show unexpected spatial and temporal variations in the O2(delta-1) airglow. The implications of these observations for the composition and general circulation of the upper venusian atmosphere are not yet understood but they provide important new constraints on comprehensive dynamical and chemical models of the upper mesosphere and lower thermosphere of Venus.

  6. Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization

    Directory of Open Access Journals (Sweden)

    María Pimentel-Santillana


    Full Text Available The nucleotide uridine trisphosphate (UTP released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y. P2Y receptors are G protein-coupled receptors expressed in many cell types. These receptors mediate several cell responses and they are involved in intracellular calcium mobilization. We investigated the role of the prostanoid PGE2 in P2Y signaling in mouse embryonic fibroblasts (MEFs, since these cells are involved in different ontogenic and physiopathological processes, among them is tissue repair following proinflammatory activation. Interestingly, Ca2+-mobilization induced by UTP-dependent P2Y activation was reduced by PGE2 when this prostanoid was produced by MEFs transfected with COX-2 or when PGE2 was added exogenously to the culture medium. This Ca2+-mobilization was important for the activation of different metabolic pathways in fibroblasts. Moreover, inhibition of COX-2 with selective coxibs prevented UTP-dependent P2Y activation in these cells. The inhibition of P2Y responses by PGE2 involves the activation of PKCs and PKD, a response that can be suppressed after pharmacological inhibition of these protein kinases. In addition to this, PGE2 reduces the fibroblast migration induced by P2Y-agonists such as UTP. Taken together, these data demonstrate that PGE2 is involved in the regulation of P2Y signaling in these cells.

  7. Metabotropic glutamate receptor 2 and corticotrophin-releasing factor receptor-1 gene expression is differently regulated by BDNF in rat primary cortical neurons

    DEFF Research Database (Denmark)

    Jørgensen, Christinna V; Klein, Anders B; El-Sayed, Mona


    Brain-derived neurotrophic factor (BDNF) is important for neuronal survival and plasticity. Incorporation of matured receptor proteins is an integral part of synapse formation. However, whether BDNF increases synthesis and integration of receptors in functional synapses directly is unclear. We...... are particularly interested in the regulation of the 5-hydroxytryptamine receptor 2A (5-HT2A R). This receptor form a functional complex with the metabotropic glutamate receptor 2 (mGluR2) and is recruited to the cell membrane by the corticotrophin-releasing factor receptor 1 (CRF-R1). The effect of BDNF on gene...... expression for all these receptors, as well as a number of immediate-early genes, was pharmacologically characterized in primary neurons from rat frontal cortex. BDNF increased CRF-R1 mRNA levels up to fivefold, whereas mGluR2 mRNA levels were proportionally downregulated. No effect on 5-HT2A R mRNA was seen...

  8. A Prototype Flux-Plate Heat-Flow Sensor for Venus Surface Heat-Flow Determinations (United States)

    Morgan, Paul; Reyes, Celso; Smrekar, Suzanne E.


    Venus is the most Earth-like planet in the Solar System in terms of size, and the densities of the two planets are almost identical when selfcompression of the two planets is taken into account. Venus is the closest planet to Earth, and the simplest interpretation of their similar densities is that their bulk compositions are almost identical. Models of the thermal evolution of Venus predict interior temperatures very similar to those indicated for the regions of Earth subject to solid-state convection, but even global analyses of the coarse Pioneer Venus elevation data suggest Venus does not lose heat by the same primary heat loss mechanism as Earth, i.e., seafloor spreading. The comparative paucity of impact craters on Venus has been interpreted as evidence for relatively recent resurfacing of the planet associated with widespread volcanic and tectonic activity. The difference in the gross tectonic styles of Venus and Earth, and the origins of some of the enigmatic volcano-tectonic features on Venus, such as the coronae, appear to be intrinsically related to Venus heat loss mechanism(s). An important parameter in understanding Venus geological evolution, therefore, is its present surface heat flow. Before the complications of survival in the hostile Venus surface environment were tackled, a prototype fluxplate heat-flow sensor was built and tested for use under synthetic stable terrestrial surface conditions. The design parameters for this prototype were that it should operate on a conforming (sand) surface, with a small, self-contained power and recording system, capable of operating without servicing for at least several days. The precision and accuracy of the system should be < 5 mW/sq m. Additional information is included in the original extended abstract.

  9. Expression of the Gastrin-Releasing Peptide Receptor, the Prostate Stem Cell Antigen and the Prostate-Specific Membrane Antigen in Lymph Node and Bone Metastases of Prostate Cancer

    NARCIS (Netherlands)

    Ananias, Hildo J. K.; van den Heuvel, Marius C.; Helfrich, Wijnand; de Jong, Igle J.


    OBJECTIVE. Cell membrane antigens like the gastrin-releasing peptide receptor (GRPR), the prostate stem cell antigen (PSCA), and the prostate-specific membrane antigen (PSMA), expressed in prostate cancer, are attractive targets for new therapeutic and diagnostic applications. Therefore, we

  10. Novel Architecture for a Long-Life, Lightweight Venus Lander

    International Nuclear Information System (INIS)

    Bugby, D.; Seghi, S.; Kroliczek, E.; Pauken, M.


    This paper describes a novel concept for an extended lifetime, lightweight Venus lander. Historically, to operate in the 480 deg. C, 90 atm, corrosive, mostly CO 2 Venus surface environment, previous landers have relied on thick Ti spherical outer shells and thick layers of internal insulation. But even the most resilient of these landers operated for only about 2 hours before succumbing to the environment. The goal on this project is to develop an architecture that extends lander lifetime to 20-25 hours and also reduces mass compared to the Pioneer Venus mission architecture. The idea for reducing mass is to: (a) contain the science instruments within a spherical high strength lightweight polymer matrix composite (PMC) tank; (b) surround the PMC tank with an annular shell of high performance insulation pre-pressurized to a level that (after landing) will exceed the external Venus surface pressure; and (c) surround the insulation with a thin Ti outer shell that contains only a net internal pressure, eliminating buckling overdesign mass. The combination of the PMC inner tank and thin Ti outer shell is lighter than a single thick Ti outer shell. The idea for extending lifetime is to add the following three features: (i) an expendable water supply that is placed within the insulation or is contained in an additional vessel within the PMC tank; (ii) a thin spherical evaporator shell placed within the insulation a short radial distance from the outer shell; and (iii) a thin heat-intercepting liquid cooled shield placed inboard of the evaporator shell. These features lower the temperature of the insulation below what it would have been with the insulation alone, reducing the internal heat leak and lengthening lifetime. The use of phase change materials (PCMs) inside the PMC tank is also analyzed as a lifetime-extending design option. The paper describes: (1) analytical modeling to demonstrate reduced mass and extended life; (2) thermal conductivity testing of high

  11. Venus Monitoring Camera (VMC/VEx) 1 micron emissivity and Magellan microwave properties of crater-related radar-dark parabolas and other terrains (United States)

    Basilevsky, A. T.; Shalygina, O. S.; Bondarenko, N. V.; Shalygin, E. V.; Markiewicz, W. J.


    The aim of this work is a comparative study of several typical radar-dark parabolas, the neighboring plains and some other geologic units seen in the study areas which include craters Adivar, Bassi, Bathsheba, du Chatelet and Sitwell, at two depths scales: the upper several meters of the study object available through the Magellan-based microwave (at 12.6 cm wavelength) properties (microwave emissivity, Fresnel reflectivity, large-scale surface roughness, and radar cross-section), and the upper hundreds microns of the object characterized by the 1 micron emissivity resulted from the analysis of the near infra-red (NIR) irradiation of the night-side of the Venusian surface measured by the Venus Monitoring Camera (VMC) on-board of Venus Express (VEx).

  12. Investigation of the middle atmosphere of Venus as a key to understand its dynamics (United States)

    Zasova, L. V.; Khatountsev, I. V.; Ignatiev, N. I.; Moroz, V. I.; Formisano, V.; Bellucci, G.


    Middle atmosphere of Venus (50 - 100km) is a very important part of the atmosphere. More than 70 % of the absorbed solar energy deposits there, providing an important source of energy to support thermal structure and dynamics. We investigate the thermal tides distribution, which is possibly responsible for the support of the superrotation. Temperature and aerosol vertical profiles were retrieved in a self consistent way from Venera-15 IR spectrometry data with vertical resolution of several kilometers. The temperature variation at the isobaric levels vs. solar longitude was presented as a superposition of the cosines with periods of 1, 1/2, 1/3 and 1/4 Venusian days with amplitude and phase depending on latitude and altitude. In particular, in the upper clouds, where most of the solar energy absorbs, all four tidal components have significant amplitudes. For the midlatitude jet the solar related periods were also found with maximal amplitude of 1/2 days period. It was also discovered that the jet changes its position in such a way that the laws of the conservation of momentum and flux are satisfied. The Fourier spectrometer on Venera-15 may be considered as a precursor of the instrument of this kind for the future missions. A functioning of the Planetary Fourier Spectrometer, with spectral range 1-50 mkm, proposed for Venus Express mission together with UV (0.2-0.5 mm) mapping spectrometer, will be enable to get answers to the fundamental questions of the middle atmosphere: clouds formation, nature of the ``unknown" UV-absorber and the mechanism of support of the superrotation. This work was supported by the grant RFFI - 02-01-17841.

  13. Geologic map of the Lakshmi Planum quadrangle (V-7), Venus (United States)

    Ivanov, Mikhail A.; Head, James W.


    The Lakshmi Planum quadrangle is in the northern hemisphere of Venus and extends from lat 50 degrees to 75 degrees N., and from long 300 degrees to 360 degrees E. The elevated volcanic plateau of Lakshmi Planum, which represents a very specific and unique class of highlands on Venus, dominates the northern half of the quadrangle. The surface of the planum stands 3-4 km above mean planetary radius and the plateau is surrounded by the highest Venusian mountain ranges, 7-10 km high. Before the Magellan mission, the geology of the Lakshmi Planum quadrangle was known on the basis of topographic data acquired by the Pioneer-Venus and Venera-15/16 altimeter and radar images received by the Arecibo telescope and Venera-15/16 spacecraft. These data showed unique topographic and morphologic structures of the mountain belts, which have no counterparts elsewhere on Venus, and the interior volcanic plateau with two large and low volcanic centers and large blocks of tessera-like terrain. From the outside, Lakshmi Planum is outlined by a zone of complexly deformed terrains that occur on the regional outer slope of Lakshmi. Vast low-lying plains surround this zone. After acquisition of the Venera-15/16 data, two classes of hypotheses were formulated to explain the unique structure of Lakshmi Planum and its surrounding. The first proposed that the western portion of Ishtar Terra, dominated by Lakshmi Planum, was a site of large-scale upwelling while the alternative hypothesis considered this region as a site of large-scale downwelling and underthrusting. Early Magellan results showed important details of the general geology of this area displayed in the Venera-15/16 images. Swarms of extensional structures and massifs of tesserae populate the southern slope of Lakshmi. The zone of fractures and grabens form a giant arc thousands of kilometers long and hundreds of kilometers wide around the southern flank of Lakshmi Planum. From the north, the deformational zones consist mostly of

  14. SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways.

    Directory of Open Access Journals (Sweden)

    Marion Morel

    Full Text Available Venus kinase receptors (VKRs are invertebrate receptor tyrosine kinases (RTKs formed by an extracellular Venus Fly Trap (VFT ligand binding domain associated via a transmembrane domain with an intracellular tyrosine kinase (TK domain. Schistosoma mansoni VKRs, SmVKR1 and SmVKR2, are both implicated in reproductive activities of the parasite. In this work, we show that the SH2 domain-containing protein SmShb is a partner of the phosphorylated form of SmVKR1. Expression of these proteins in Xenopus oocytes allowed us to demonstrate that the SH2 domain of SmShb interacts with the phosphotyrosine residue (pY979 located in the juxtamembrane region of SmVKR1. This interaction leads to phosphorylation of SmShb on tyrosines and promotes SmVKR1 signaling towards the JNK pathway. SmShb transcripts are expressed in all parasite stages and they were found in ovary and testes of adult worms, suggesting a possible colocalization of SmShb and SmVKR1 proteins. Silencing of SmShb in adult S. mansoni resulted in an accumulation of mature sperm in testes, indicating a possible role of SmShb in gametogenesis.

  15. SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways. (United States)

    Morel, Marion; Vanderstraete, Mathieu; Cailliau, Katia; Hahnel, Steffen; Grevelding, Christoph G; Dissous, Colette


    Venus kinase receptors (VKRs) are invertebrate receptor tyrosine kinases (RTKs) formed by an extracellular Venus Fly Trap (VFT) ligand binding domain associated via a transmembrane domain with an intracellular tyrosine kinase (TK) domain. Schistosoma mansoni VKRs, SmVKR1 and SmVKR2, are both implicated in reproductive activities of the parasite. In this work, we show that the SH2 domain-containing protein SmShb is a partner of the phosphorylated form of SmVKR1. Expression of these proteins in Xenopus oocytes allowed us to demonstrate that the SH2 domain of SmShb interacts with the phosphotyrosine residue (pY979) located in the juxtamembrane region of SmVKR1. This interaction leads to phosphorylation of SmShb on tyrosines and promotes SmVKR1 signaling towards the JNK pathway. SmShb transcripts are expressed in all parasite stages and they were found in ovary and testes of adult worms, suggesting a possible colocalization of SmShb and SmVKR1 proteins. Silencing of SmShb in adult S. mansoni resulted in an accumulation of mature sperm in testes, indicating a possible role of SmShb in gametogenesis.


    International Nuclear Information System (INIS)

    Ancelin, C.; Le, P.; DeSaint-Quentin, S.; Villatte, N.


    This paper presents EXPRESS, an expert system developed for the automation of reliability studies. The first part consists in the description of the method for static thermohydraulic systems. In this step, the authors define the knowledge representation based on the two inference engines - ALOUETTE and LCR developed by EDF. They explain all the process to construct a fault tree from a topological and functional description of the system. Numerous examples are exhibited in illustration of the method. This is followed by the lessons derived from the studies performed on some safety systems of the PALUEL nuclear plant. The development of the same approach for electric power systems is described, insisting on the difference resulting from the sequential nature of these systems. Finally, they show the main advantages identified during the studies

  17. Mantle dynamics in Mars and Venus: Influence of an immobile lithosphere on three-dimensional mantle convection

    International Nuclear Information System (INIS)

    Schubert, G.; Bercovici; Glatzmaier, G.A.


    Numerical calculations of fully three-dimensional convection in constant viscosity, compressible spherical shells are interpreted in terms of possible convective motions in the mantles of Venus and Mars. The shells are heated both internally and from below to account for radiogenic heating, secular cooling, and heat flow from the core. The lower boundary of each of the shells is isothermal and shear stress free, as appropriate to the interface between a mantle and a liquid outer core. The upper boundary of each of the shells is rigid and isothermal, as appropriate to the base of a thick immobile lithosphere. Calculations with shear stress-free upper boundaries are also carried out to assess the role of the rigid surface condition. The ratio of the inner radius of each shell to its outer radius is in accordance with possible core sizes in both Venus and Mars. A calculation is also carried out for a Mars model with a small core to simulate mantle convection during early core formation. Different relative proportions of internal and bottom heating are investigated, ranging from nearly complete heating from within to almost all heating from below. The Rayleigh numbers of all the cases are approximately 100 times the critical Rayleigh numbers for the onset of convection. Cylindrical plumes are the prominent form of upwelling in the models independent of the surface boundary condition so long as sufficient heat derives from the core. Thus major volcanic centers on Mars, such as Tharsis and Elysium, and the coronae and some equatorial highlands on Venus may be the surface expressions of cylindrical mantle plumes

  18. Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane

    Directory of Open Access Journals (Sweden)

    W. Lucca-Junior


    Full Text Available Chaperone members of the protein disulfide isomerase family can catalyze the thiol-disulfide exchange reaction with pairs of cysteines. There are 14 protein disulfide isomerase family members, but the ability to catalyze a thiol disulfide exchange reaction has not been demonstrated for all of them. Human endoplasmic reticulum protein chaperone thio-oxidoreductase (ERp18 shows partial oxidative activity as a protein disulfide isomerase. The aim of the present study was to evaluate the participation of ERp18 in gonadotropin-releasing hormone receptor (GnRHR expression at the plasma membrane. Cos-7 cells were cultured, plated, and transfected with 25 ng (unless indicated wild-type human GnRHR (hGnRHR or mutant GnRHR (Cys14Ala and Cys200Ala and pcDNA3.1 without insert (empty vector or ERp18 cDNA (75 ng/well, pre-loaded for 18 h with 1 µCi myo-[2-3H(N]-inositol in 0.25 mL DMEM and treated for 2 h with buserelin. We observed a decrease in maximal inositol phosphate (IP production in response to buserelin in the cells co-transfected with hGnRHR, and a decrease from 20 to 75 ng of ERp18 compared with cells co-transfected with hGnRHR and empty vector. The decrease in maximal IP was proportional to the amount of ERp18 DNA over the range examined. Mutants (Cys14Ala and Cys200Ala that could not form the Cys14-Cys200 bridge essential for plasma membrane routing of the hGnRHR did not modify maximal IP production when they were co-transfected with ERp18. These results suggest that ERp18 has a reduction role on disulfide bonds in wild-type hGnRHR folding.

  19. Venus' Spectral Signatures and the Potential for Life in the Clouds. (United States)

    Limaye, Sanjay S; Mogul, Rakesh; Smith, David J; Ansari, Arif H; Słowik, Grzegorz P; Vaishampayan, Parag


    The lower cloud layer of Venus (47.5-50.5 km) is an exceptional target for exploration due to the favorable conditions for microbial life, including moderate temperatures and pressures (∼60°C and 1 atm), and the presence of micron-sized sulfuric acid aerosols. Nearly a century after the ultraviolet (UV) contrasts of Venus' cloud layer were discovered with Earth-based photographs, the substances and mechanisms responsible for the changes in Venus' contrasts and albedo are still unknown. While current models include sulfur dioxide and iron chloride as the UV absorbers, the temporal and spatial changes in contrasts, and albedo, between 330 and 500 nm, remain to be fully explained. Within this context, we present a discussion regarding the potential for microorganisms to survive in Venus' lower clouds and contribute to the observed bulk spectra. In this article, we provide an overview of relevant Venus observations, compare the spectral and physical properties of Venus' clouds to terrestrial biological materials, review the potential for an iron- and sulfur-centered metabolism in the clouds, discuss conceivable mechanisms of transport from the surface toward a more habitable zone in the clouds, and identify spectral and biological experiments that could measure the habitability of Venus' clouds and terrestrial analogues. Together, our lines of reasoning suggest that particles in Venus' lower clouds contain sufficient mass balance to harbor microorganisms, water, and solutes, and potentially sufficient biomass to be detected by optical methods. As such, the comparisons presented in this article warrant further investigations into the prospect of biosignatures in Venus' clouds. Key Words: Venus-Clouds-Life-Habitability-Microorganism-Albedo-Spectroscopy-Biosignatures-Aerosol-Sulfuric Acid. Astrobiology 18, xxx-xxx.

  20. On the Thermal Protection Systems of Landers for Venus Exploration (United States)

    Ekonomov, A. P.; Ksanfomality, L. V.


    The landers of the Soviet Venera series—from Venera-9 to Venera-14—designed at the Lavochkin Association are a man-made monument to spectacular achievements of Soviet space research. For more than 40 years, they have remained the uneclipsed Soviet results in space studies of the Solar System. Within the last almost half a century, the experiments carried out by the Venera-9 to Venera-14 probes for studying the surface of the planet have not been repeated by any space agency in the world, mainly due to quite substantial technical problems. Since that time, no Russian missions with landers have been sent to Venus either. On Venus, there is an anoxic carbon dioxide atmosphere, where the pressure is 9.2 MPa and the temperature is 735 K near the surface. A long-lived lander should experience these conditions for an appreciable length of time. What technical solutions could provide a longer operation time for a new probe investigating the surface of Venus, if its thermal scheme is constructed similar to that of the Venera series? Onboard new landers, there should be a sealed module, where the physical conditions required for operating scientific instruments are maintained for a long period. At the same time, new high-temperature electronic equipment that remains functional under the above-mentioned conditions have appeared. In this paper, we consider and discuss different variants of the system for a long-lived sealed lander, in particular, the absorption of the penetrating heat due to water evaporation and the thermal protection construction for the instruments with intermediate characteristics.

  1. Carl Sagan and the Exploration of Mars and Venus (United States)

    Toon, Owen B.; Condon, Estelle P. (Technical Monitor)


    Inspired by childhood readings of books by Edgar Rice Burroughs, Carl Sagan's first interest in planetary science focused on Mars and Venus. Typical of much of his career he was skeptical of early views about these planets. Early in this century it was thought that the Martian wave of darkening, a seasonal albedo change on the planet, was biological in origin. He suggested instead that it was due to massive dust storms, as was later shown to be the case. He was the first to recognize that Mars has huge topography gradients across its surface. During the spacecraft era, as ancient river valleys were found on the planet, he directed studies of Mars' ancient climate. He suggested that changes in the planets orbit were involved in climate shifts on Mars, just as they are on Earth. Carl had an early interest in Venus. Contradictory observations led to a controversy about the surface temperature, and Carl was one of the first to recognize that Venus has a massive greenhouse effect at work warming its surface. His work on radiative transfer led to an algorithm that was extensively used by modelers of the Earth's climate and whose derivatives still dominate the calculation of radiative transfer in planetary atmospheres today. Carl inspired a vast number of young scientists through his enthusiasm for new ideas and discoveries, his skeptical approach, and his boundless energy. I had the privilege to work in Carl's laboratory during the peak of the era of Mars' initial exploration. It was an exciting time, and place. Carl made it a wonderful experience.

  2. Announcing the Venus Transit 2004 (VT-2004) Programme (United States)


    Rare Celestial Event to be Observed by Millions Summary On June 8, 2004, Venus - the Earth's sister planet - will pass in front of the Sun. This event, a 'transit', is extremely rare - the last one occurred in 1882, 122 years ago. Easily observable in Europe, Asia, Africa and Australia, it is likely to attract the attention of millions of people on these continents and, indeed, all over the world. On this important occasion, the European Southern Observatory (ESO) has joined forces with the European Association for Astronomy Education (EAAE), the Institut de Mécanique Céleste et de Calcul des Éphémérides (IMCCE) and the Observatoire de Paris in France, as well as the Astronomical Institute of the Academy of Sciences of the Czech Republic to establish the Venus Transit 2004 (VT-2004) public education programme. It is supported by the European Commission in the framework of the European Science and Technology Week and takes advantage of this extraordinary celestial event to expose the public - in a well-considered, interactive and exciting way - to a number of fundamental issues at the crucial interface between society and basic science. VT-2004 has several components, including an instructive and comprehensive website ( It is directed towards the wide public in general and the media, school students and their teachers, as well as amateur astronomers in particular. It invites all interested persons to participate actively in the intercontinental VT-2004 Observing Campaign (that reenacts historical Venus Transit observations) and the VT-2004 Video Contest. During the VT-2004 Final Event in November, the winners of the Video Contest will be chosen by an international jury. This meeting will also serve to discuss the project and its impact. The outcome of this rare celestial event and the overall experience from this unique public education project will clearly be of very wide interest, not just in the field of astronomy.

  3. Estimates of elastic plate thicknesses beneath large volcanos on Venus (United States)

    Mcgovern, Patrick J.; Solomon, Sean C.


    Megellan radar imaging and topography data are now available for a number of volcanos on Venus greater than 100 km in radius. These data can be examined to reveal evidence of the flexural response of the lithosphere to the volcanic load. On Earth, flexure beneath large hotspot volcanos results in an annual topographic moat that is partially to completely filled in by sedimentation and mass wasting from the volcano's flanks. On Venus, erosion and sediment deposition are considered to be negligible at the resolution of Magellan images. Thus, it may be possible to observe evidence of flexure by the ponding of recent volcanic flows in the moat. We also might expect to find topographic signals from unfilled moats surrounding large volcanos on Venus, although these signals may be partially obscured by regional topography. Also, in the absence of sedimentation, tectonic evidence of deformation around large volcanos should be evident except where buried by very young flows. We use analytic solutions in axisymmetric geometry for deflections and stresses resulting from loading of a plate overlying an inviscid fluid. Solutions for a set of disk loads are superimposed to obtain a solution for a conical volcano. The deflection of the lithosphere produces an annular depression or moat, the extent of which can be estimated by measuring the distance from the volcano's edge to the first zero crossing or to the peak of the flexural arch. Magellan altimetry data records (ARCDRs) from data cycle 1 are processed using the GMT mapping and graphics software to produce topographic contour maps of the volcanos. We then take topographic profiles that cut across the annular and ponded flows seen on the radar images. By comparing the locations of these flows to the predicted moat locations from a range of models, we estimate the elastic plate thickness that best fits the observations, together with the uncertainty in that estimate.

  4. ADS experimental benchmarks of VENUS-1 in China

    International Nuclear Information System (INIS)

    Xia Haihong; Xia Pu; Han Yinlu


    The present report describes here are the calculation of four nuclear data libraries on China ADS Venus-1 sub critical facility, using same calculation code: the Monte Carlo code MCNP-5. The libraries are ENDF/B-VI.6, ENDF/B-7, CENDL 3.1 and Library ADS 2.0. The results of k eff , K p , Λ, l p and β eff for four thermal fuel configurations and the total neutron flux, the neutron flux distributions, neutron spectra in experimental channel for two thermal fuel configurations which driven by external neutron source (D-D and D-T source) are evaluated. (J.P.N.)

  5. Images from Galileo of the Venus cloud deck (United States)

    Belton, M.J.S.; Gierasch, P.J.; Smith, M.D.; Helfenstein, P.; Schinder, P.J.; Pollack, James B.; Rages, K.A.; Ingersoll, A.P.; Klaasen, K.P.; Veverka, J.; Anger, C.D.; Carr, M.H.; Chapman, C.R.; Davies, M.E.; Fanale, F.P.; Greeley, R.; Greenberg, R.; Head, J. W.; Morrison, D.; Neukum, G.; Pilcher, C.B.


    Images of Venus taken at 418 (violet) and 986 [near-infrared (NIR)] nanometers show that the morphology and motions of large-scale features change with depth in the cloud deck. Poleward meridional velocities, seen in both spectral regions, are much reduced in the NIR. In the south polar region the markings in the two wavelength bands are strongly anticorrelated. The images follow the changing state of the upper cloud layer downwind of the subsolar point, and the zonal flow field shows a longitudinal periodicity that may be coupled to the formation of large-scale planetary waves. No optical lightning was detected.

  6. Venus gravity and topography: 60th degree and order model (United States)

    Konopliv, A. S.; Borderies, N. J.; Chodas, P. W.; Christensen, E. J.; Sjogren, W. L.; Williams, B. G.; Balmino, G.; Barriot, J. P.


    We have combined the most recent Pioneer Venus Orbiter (PVO) and Magellan (MGN) data with the earlier 1978-1982 PVO data set to obtain a new 60th degree and order spherical harmonic gravity model and a 120th degree and order spherical harmonic topography model. Free-air gravity maps are shown over regions where the most marked improvement has been obtained (Ishtar-Terra, Alpha, Bell and Artemis). Gravity versus topography relationships are presented as correlations per degree and axes orientation.

  7. Large-scale volcanism associated with coronae on Venus (United States)

    Roberts, K. Magee; Head, James W.


    The formation and evolution of coronae on Venus are thought to be the result of mantle upwellings against the crust and lithosphere and subsequent gravitational relaxation. A variety of other features on Venus have been linked to processes associated with mantle upwelling, including shield volcanoes on large regional rises such as Beta, Atla and Western Eistla Regiones and extensive flow fields such as Mylitta and Kaiwan Fluctus near the Lada Terra/Lavinia Planitia boundary. Of these features, coronae appear to possess the smallest amounts of associated volcanism, although volcanism associated with coronae has only been qualitatively examined. An initial survey of coronae based on recent Magellan data indicated that only 9 percent of all coronae are associated with substantial amounts of volcanism, including interior calderas or edifices greater than 50 km in diameter and extensive, exterior radial flow fields. Sixty-eight percent of all coronae were found to have lesser amounts of volcanism, including interior flooding and associated volcanic domes and small shields; the remaining coronae were considered deficient in associated volcanism. It is possible that coronae are related to mantle plumes or diapirs that are lower in volume or in partial melt than those associated with the large shields or flow fields. Regional tectonics or variations in local crustal and thermal structure may also be significant in determining the amount of volcanism produced from an upwelling. It is also possible that flow fields associated with some coronae are sheet-like in nature and may not be readily identified. If coronae are associated with volcanic flow fields, then they may be a significant contributor to plains formation on Venus, as they number over 300 and are widely distributed across the planet. As a continuation of our analysis of large-scale volcanism on Venus, we have reexamined the known population of coronae and assessed quantitatively the scale of volcanism associated

  8. Venus gravity anomalies and their correlations with topography (United States)

    Sjogren, W. L.; Bills, B. G.; Birkeland, P. W.; Esposito, P. B.; Konopliv, A. R.; Mottinger, N. A.; Ritke, S. J.; Phillips, R. J.


    This report provides a summary of the high-resolution gravity data obtained from the Pioneer Venus Orbiter radio tracking data. Gravity maps, covering a 70 deg latitude band through 360 deg of longitude, are displayed as line-of-sight and vertical gravity. Topography converted to gravity and Bouguer gravity maps are also shown in both systems. Topography to gravity ratios are made over several regions of the planet. There are markedly different ratios for the Aphrodite area as compared to the Beta and Atla areas.

  9. Coldspots and hotspots - Global tectonics and mantle dynamics of Venus (United States)

    Bindschadler, Duane L.; Schubert, Gerald; Kaula, William M.


    Based on geologic observations provided by Magellan's first cycle of data collection and recent models of mantle convection in spherical shells and crustal deformation, the major topographic and geologic features of Venus are incorporated into a model of global mantle dynamics. Consideration is given to volcanic rises, such as Beta Regio and Atla Regio, plateau-shaped highlands dominated by complex ridged terrain (e.g., Ovda Regio and Alpha Regio), and circular lowland regions, such as Atalanta Planitia. Each of these features is related to either mantle plumes (hotspots) or mantle downwellings (coldspots).

  10. Venus-Earth-Mars: comparative climatology and the search for life in the solar system. (United States)

    Launius, Roger D


    Both Venus and Mars have captured the human imagination during the twentieth century as possible abodes of life. Venus had long enchanted humans-all the more so after astronomers realized it was shrouded in a mysterious cloak of clouds permanently hiding the surface from view. It was also the closest planet to Earth, with nearly the same size and surface gravity. These attributes brought myriad speculations about the nature of Venus, its climate, and the possibility of life existing there in some form. Mars also harbored interest as a place where life had or might still exist. Seasonal changes on Mars were interpreted as due to the possible spread and retreat of ice caps and lichen-like vegetation. A core element of this belief rested with the climatology of these two planets, as observed by astronomers, but these ideas were significantly altered, if not dashed during the space age. Missions to Venus and Mars revealed strikingly different worlds. The high temperatures and pressures found on Venus supported a "runaway greenhouse theory," and Mars harbored an apparently lifeless landscape similar to the surface of the Moon. While hopes for Venus as an abode of life ended, the search for evidence of past life on Mars, possibly microbial, remains a central theme in space exploration. This survey explores the evolution of thinking about the climates of Venus and Mars as life-support systems, in comparison to Earth.

  11. Venus-Earth-Mars: Comparative Climatology and the Search for Life in the Solar System (United States)

    Launius, Roger D.


    Both Venus and Mars have captured the human imagination during the twentieth century as possible abodes of life. Venus had long enchanted humans—all the more so after astronomers realized it was shrouded in a mysterious cloak of clouds permanently hiding the surface from view. It was also the closest planet to Earth, with nearly the same size and surface gravity. These attributes brought myriad speculations about the nature of Venus, its climate, and the possibility of life existing there in some form. Mars also harbored interest as a place where life had or might still exist. Seasonal changes on Mars were interpreted as due to the possible spread and retreat of ice caps and lichen-like vegetation. A core element of this belief rested with the climatology of these two planets, as observed by astronomers, but these ideas were significantly altered, if not dashed during the space age. Missions to Venus and Mars revealed strikingly different worlds. The high temperatures and pressures found on Venus supported a “runaway greenhouse theory,” and Mars harbored an apparently lifeless landscape similar to the surface of the Moon. While hopes for Venus as an abode of life ended, the search for evidence of past life on Mars, possibly microbial, remains a central theme in space exploration. This survey explores the evolution of thinking about the climates of Venus and Mars as life-support systems, in comparison to Earth. PMID:25371106

  12. Venus Mobile Explorer with RPS for Active Cooling: A Feasibility Study (United States)

    Leifer, Stephanie D.; Green, Jacklyn R.; Balint, Tibor S.; Manvi, Ram


    We present our findings from a study to evaluate the feasibility of a radioisotope power system (RPS) combined with active cooling to enable a long-duration Venus surface mission. On-board power with active cooling technology featured prominently in both the National Research Council's Decadal Survey and in the 2006 NASA Solar System Exploration Roadmap as mission-enabling for the exploration of Venus. Power and cooling system options were reviewed and the most promising concepts modeled to develop an assessment tool for Venus mission planners considering a variety of future potential missions to Venus, including a Venus Mobile Explorer (either a balloon or rover concept), a long-lived Venus static lander, or a Venus Geophysical Network. The concepts modeled were based on the integration of General Purpose Heat Source (GPHS) modules with different types of Stirling cycle heat engines for power and cooling. Unlike prior investigations which reported on single point design concepts, this assessment tool allows the user to generate either a point design or parametric curves of approximate power and cooling system mass, power level, and number of GPHS modules needed for a "black box" payload housed in a spherical pressure vessel.

  13. Venus-Earth-Mars: Comparative Climatology and the Search for Life in the Solar System

    Directory of Open Access Journals (Sweden)

    Roger D. Launius


    Full Text Available Both Venus and Mars have captured the human imagination during the twentieth century as possible abodes of life. Venus had long enchanted humans—all the more so after astronomers realized it was shrouded in a mysterious cloak of clouds permanently hiding the surface from view. It was also the closest planet to Earth, with nearly the same size and surface gravity. These attributes brought myriad speculations about the nature of Venus, its climate, and the possibility of life existing there in some form. Mars also harbored interest as a place where life had or might still exist. Seasonal changes on Mars were interpreted as due to the possible spread and retreat of ice caps and lichen-like vegetation. A core element of this belief rested with the climatology of these two planets, as observed by astronomers, but these ideas were significantly altered, if not dashed during the space age. Missions to Venus and Mars revealed strikingly different worlds. The high temperatures and pressures found on Venus supported a “runaway greenhouse theory,” and Mars harbored an apparently lifeless landscape similar to the surface of the Moon. While hopes for Venus as an abode of life ended, the search for evidence of past life on Mars, possibly microbial, remains a central theme in space exploration. This survey explores the evolution of thinking about the climates of Venus and Mars as life-support systems, in comparison to Earth.


    Energy Technology Data Exchange (ETDEWEB)

    Kane, Stephen R.; Gelino, Dawn M. [NASA Exoplanet Science Institute, Caltech, MS 100-22, 770 South Wilson Avenue, Pasadena, CA 91125 (United States); Barclay, Thomas, E-mail: [NASA Ames Research Center, M/S 244-30, Moffett Field, CA 94035 (United States)


    Transiting planets have greatly expanded and diversified the exoplanet field. These planets provide greater access to characterization of exoplanet atmospheres and structure. The Kepler mission has been particularly successful in expanding the exoplanet inventory, even to planets smaller than the Earth. The orbital period sensitivity of the Kepler data is now extending into the habitable zones of their host stars, and several planets larger than the Earth have been found to lie therein. Here we examine one such proposed planet, Kepler-69c. We provide new orbital parameters for this planet and an in-depth analysis of the habitable zone. We find that, even under optimistic conditions, this 1.7 R{sub Circled-Plus} planet is unlikely to be within the habitable zone of Kepler-69. Furthermore, the planet receives an incident flux of 1.91 times the solar constant, which is similar to that received by Venus. We thus suggest that this planet is likely a super-Venus rather than a super-Earth in terms of atmospheric properties and habitability, and we propose follow-up observations to disentangle the ambiguity.

  15. Radiative heat transfer and water content in atmosphere of Venus

    International Nuclear Information System (INIS)

    Yarov, M.Y.; Gal'stev, A.P.; Shari, V.P.


    The authors present the procedure for calculating optical characteristics of the main components and the effective fluxes in the atmosphere of Venus, and concrete results of the calculations. They are compared to the results of other authors and to the experimantal data. Integration was carried out by the Simpson method with automatic selection of the step or interval for a given relative integrating accuracy delta. The calculations were done with a BESM-6 computer. Using this procedure and data on absorbtion coefficients, calculations of the spectrum of effective flux were carried out for a pure carbon dioxide atmosphere and for an atmosphere containing water vapor at various relative admixtures, for different altitude profiles of temperature and cloudiness albedo. Thus, the comparisons made, enable the authors to judge about the degree of agreement of the F(z) altitude profile, in some regions of the planet where measurements have been made, rather than about the absolute values of the heat fluxes. In conclusion, the authors point out that the task of calculating in detail the radiation balance in Venus' lower atmosphere, as also the problem of a more reliable interpretation of the experimantal data, is coupled with the necessity of elaborating reliable models of the atmospheric components' optical characteristics, which determine the radiative transfer of heat

  16. Venus - Limited extension and volcanism along zones of lithospheric weakness (United States)

    Schaber, G. G.


    Three global-scale zones of possible tectonic origin are described as occurring along broad, low rises within the Equatorial Highlands on Venus (lat 50 deg N to 50 deg S, long 60 deg to 310 deg). The two longest of these tectonic zones, the Aphrodite-Beta and Themis-Atla zones, extend for 21,000 and 14,000 km, respectively. Several lines of evidence indicate that Beta and Atla Regiones, located at the only two intersections of the three major tectonic zones, are dynamically supported volcanic terranes associated with currently active volcanism. Rift valleys south of Aphrodite Terra and between Beta and Phoebe Regiones are characterized by 75- to 100-km widths, raised rims, and extensions of only a few tens of kilometers, about the same magnitudes as in continental rifts on the earth. Horizontal extension on Venus was probably restricted by an early choking-off of plate motion by high crustal and upper-mantle temperatures, and the subsequent loss of water and an asthenosphere.

  17. VENUS-2 Benchmark Problem Analysis with HELIOS-1.9

    International Nuclear Information System (INIS)

    Jeong, Hyeon-Jun; Choe, Jiwon; Lee, Deokjung


    Since there are reliable results of benchmark data from the OECD/NEA report of the VENUS-2 MOX benchmark problem, by comparing benchmark results users can identify the credibility of code. In this paper, the solution of the VENUS-2 benchmark problem from HELIOS 1.9 using the ENDF/B-VI library(NJOY91.13) is compared with the result from HELIOS 1.7 with consideration of the MCNP-4B result as reference data. The comparison contains the results of pin cell calculation, assembly calculation, and core calculation. The eigenvalues from those are considered by comparing the results from other codes. In the case of UOX and MOX assemblies, the differences from the MCNP-4B results are about 10 pcm. However, there is some inaccuracy in baffle-reflector condition, and relatively large differences were found in the MOX-reflector assembly and core calculation. Although HELIOS 1.9 utilizes an inflow transport correction, it seems that it has a limited effect on the error in baffle-reflector condition


    International Nuclear Information System (INIS)

    Kane, Stephen R.; Gelino, Dawn M.; Barclay, Thomas


    Transiting planets have greatly expanded and diversified the exoplanet field. These planets provide greater access to characterization of exoplanet atmospheres and structure. The Kepler mission has been particularly successful in expanding the exoplanet inventory, even to planets smaller than the Earth. The orbital period sensitivity of the Kepler data is now extending into the habitable zones of their host stars, and several planets larger than the Earth have been found to lie therein. Here we examine one such proposed planet, Kepler-69c. We provide new orbital parameters for this planet and an in-depth analysis of the habitable zone. We find that, even under optimistic conditions, this 1.7 R ⊕ planet is unlikely to be within the habitable zone of Kepler-69. Furthermore, the planet receives an incident flux of 1.91 times the solar constant, which is similar to that received by Venus. We thus suggest that this planet is likely a super-Venus rather than a super-Earth in terms of atmospheric properties and habitability, and we propose follow-up observations to disentangle the ambiguity.

  19. Stress distribution and topography of Tellus Regio, Venus (United States)

    Williams, David R.; Greeley, Ronald


    The Tellus Regio area of Venus represents a subset of a narrow latitude band where Pioneer Venus Orbiter (PVO) altimetry data, line-of-sight (LOS) gravity data, and Venera 15/16 radar images have all been obtained with good resolution. Tellus Regio also has a wide variety of surface morphologic features, elevations ranging up to 2.5 km, and a relatively low LOS gravity anomaly. This area was therefore chosen in order to examine the theoretical stress distributions resulting from various models of compensation of the observed topography. These surface stress distributions are then compared with the surface morphology revealed in the Venera 15/16 radar images. Conclusions drawn from these comparisons will enable constraints to be put on various tectonic parameters relevant to Tellus Regio. The stress distribution is calculated as a function of the topography, the equipotential anomaly, and the assumed model parameters. The topography data is obtained from the PVO altimetry. The equipotential anomaly is estimated from the PVO LOS gravity data. The PVO LOS gravity represents the spacecraft accelerations due to mass anomalies within the planet. These accelerations are measured at various altitudes and angles to the local vertical and therefore do not lend themselves to a straightforward conversion. A minimum variance estimator of the LOS gravity data is calculated, taking into account the various spacecraft altitudes and LOS angles and using the measured PVO topography as an a priori constraint. This results in an estimated equivalent surface mass distribution, from which the equipotential anomaly is determined.

  20. Stress distribution and topography of Tellus Regio, Venus

    International Nuclear Information System (INIS)

    Williams, D.R.; Greeley, R.


    The Tellus Regio area of Venus represents a subset of a narrow latitude band where Pioneer Venus Orbiter (PVO) altimetry data, line-of-sight (LOS) gravity data, and Venera 15/16 radar images have all been obtained with good resolution. Tellus Regio also has a wide variety of surface morphologic features, elevations ranging up to 2.5 km, and a relatively low LOS gravity anomaly. This area was therefore chosen in order to examine the theoretical stress distributions resulting from various models of compensation of the observed topography. These surface stress distributions are then compared with the surface morphology revealed in the Venera 15/16 radar images. Conclusions drawn from these comparisons will enable constraints to be put on various tectonic parameters relevant to Tellus Regio. The stress distribution is calculated as a function of the topography, the equipotential anomaly, and the assumed model parameters. The topography data is obtained from the PVO altimetry. The equipotential anomaly is estimated from the PVO LOS gravity data. The PVO LOS gravity represents the spacecraft accelerations due to mass anomalies within the planet. These accelerations are measured at various altitudes and angles to the local vertical and therefore do not lend themselves to a straightforward conversion. A minimum variance estimator of the LOS gravity data is calculated, taking into account the various spacecraft altitudes and LOS angles and using the measured PVO topography as an a priori constraint. This results in an estimated equivalent surface mass distribution, from which the equipotential anomaly is determined

  1. Fluid outflows from Venus impact craters - Analysis from Magellan data (United States)

    Asimow, Paul D.; Wood, John A.


    Many impact craters on Venus have unusual outflow features originating in or under the continuous ejecta blankets and continuing downhill into the surrounding terrain. These features clearly resulted from flow of low-viscosity fluids, but the identity of those fluids is not clear. In particular, it should not be assumed a priori that the fluid is an impact melt. A number of candidate processes by which impact events might generate the observed features are considered, and predictions are made concerning the rheological character of flows produce by each mechanism. A sample of outflows was analyzed using Magellan images and a model of unconstrained Bingham plastic flow on inclined planes, leading to estimates of viscosity and yield strength for the flow materials. It is argued that at least two different mechanisms have produced outflows on Venus: an erosive, channel-forming process and a depositional process. The erosive fluid is probably an impact melt, but the depositional fluid may consist of fluidized solid debris, vaporized material, and/or melt.

  2. Geologic map of the Rusalka Planitia Quadrangle (V-25), Venus (United States)

    Young, Duncan A.; Hansen, Vicki L.


    The Rusalka Planitia quadrangle (herein referred to as V-25) occupies an 8.1 million square kilometer swath of lowlands nestled within the eastern highlands of Aphrodite Terra on Venus. The region (25?-0? N., 150?-180? E.) is framed by the crustal plateau Thetis Regio to the southwest, the coronae of the Diana-Dali chasmata complex to the south, and volcanic rise Atla Regio to the west. Regions to the north, and the quadrangle itself, are part of the vast lowlands, which cover four-fifths of the surface of Venus. The often-unspectacular lowlands of Venus are typically lumped together as ridged or regional plains. However, detailed mapping reveals the mode of resurfacing in V-25's lowlands: a mix of corona-related flow fields and local edifice clusters within planitia superimposed on a background of less clearly interpretable extended flow fields, large volcanoes, probable corona fragments, and edifice-flow complexes. The history detailed within the Rusalka Planitia quadrangle is that of the extended evolution of long-wavelength topographic basins in the presence of episodes of extensive corona-related volcanism, pervasive low-intensity small-scale eruptions, and an early phase of regional circumferential shortening centered on central Aphrodite Terra. Structural reactivation both obscures and illuminates the tectonic development of the region. The data are consistent with progressive lithospheric thickening, although the critical lack of an independent temporal marker on Venus severely hampers our ability to test this claim and correlate between localities. Two broad circular basins dominate V-25 geology: northern Rusalka Planitia lies in the southern half of the quadrangle, whereas the smaller Llorona Planitia sits along the northwestern corner of V-25. Similar large topographic basins occur throughout the lowlands of Venus, and gravity data suggest that some basins may represent dynamic topography over mantle downwellings. Both planitiae include coronae and

  3. Terrestrial spreading centers under Venus conditions - Evaluation of a crustal spreading model for Western Aphrodite Terra (United States)

    Sotin, C.; Senske, D. A.; Head, J. W.; Parmentier, E. M.


    The model of Reid and Jackson (1981) for terrestrial spreading centers is applied to Venus conditions. On the basis of spreading rate, mantle temperature, and surface temperature, the model predicts both isostatic topography and crustal thickness. The model and Pioneer Venus altimetry and gravity data are used to test the hypothesis of Head and Crumpler (1987) that Western Aphrodite Terra is the location of crustal spreading on Venus. It is concluded that a spreading center model for Ovda Regio in Western Aphrodite Terra could account for the observed topography and line-of-sight gravity anomalies found in the Pioneer data.

  4. Long term evolution of temperature in the venus upper atmosphere at the evening and morning terminators (United States)

    Krause, P.; Sornig, M.; Wischnewski, C.; Kostiuk, T.; Livengood, T. A.; Herrmann, M.; Sonnabend, G.; Stangier, T.; Wiegand, M.; Pätzold, M.; Mahieux, A.; Vandaele, A. C.; Piccialli, A.; Montmessin, F.


    This paper contains a comprehensive dataset of long-term observations between 2009 and 2015 at the upper mesosphere/lower thermosphere providing temperature values at different locations of the morning and evening side of the terminator of Venus. Temperature information is obtained by line-resolved spectroscopy of Doppler broadened CO2 transitions features. Results are restricted to a pressure level of 1 μbar, ∼110 km altitude due the nature of the addressed non-LTE CO2 emission line at 10 μm. The required high spectral resolution of the instrumentation is provided by the ground-based spectrometers THIS (University of Cologne) and HIPWAC (NASA GSFC). For the first time upper mesosphere/lower thermosphere temperatures at the Venusian terminator derived from IR-het spectroscopy between 2009 and 2015 are investigated in order to clarify the local-time dependences, latitudinal dependences and the long-term trend. Measured temperatures were distributed in the range between 140 K and 240 K, with mean values equal to 199 K ± 17 K for the morning side of the terminator and 195 K ± 19 K for the evening side of the terminator. Within the uncertainty no difference between the averaged morning and evening terminator side temperature is found. In addition, no strong latitudinal dependency is observed at these near terminator local times. In contrast IR-het data from 2009 show a strong latitudinal dependency at noon, with a temperature difference of around 60 K between the equatorial and polar region (Sonnabend et al., 2012). Accord with the instruments of the Venus Express mission a northern-southern hemispherical symmetry is observed (Mahieux et al., 2012; Piccialli et al., 2015). The data shows no consistent long-term temperature trend throughout the six years of observation, but a variability in the order of tens of Kelvin for the different observing runs representing a time step of few month to two years. This is about the same order of magnitude as the variability

  5. The effect of melatonin from slow-release implants on basic and TLR-4-mediated gene expression of inflammatory cytokines and their receptors in the choroid plexus in ewes. (United States)

    Kowalewska, M; Herman, A P; Szczepkowska, A; Skipor, J


    The present study concerns the effect of melatonin from slow-release implants on the expression of genes coding interleukin-1β (Il1B), inerleukin-6 (Il6), tumour necrosis factor α (Tnf) and their receptors: IL-1 receptor type I (Il1r1) and type II (Il1r2), IL-6 receptor (Il6r) and signal transducer (Il6st), TNFα receptor type I (Tnfrsf1a) and II (Tnfrsf1b) and retinoid-related orphan receptor α (RorA) and Rev.-erbα in the ovine choroid plexus (CP) under basal and lipopolysaccharide (LPS)-challenged conditions. Studies were performed on four groups: 1) sham-implanted and placebo-treated, 2) melatonin-implanted (Melovine, 18mg) and placebo-treated, 3) sham-implanted and LPS-treated (400ng/kg of body weight) and 4) melatonin-implanted and LPS-treated. Under basal conditions, we observed weak expression of Tnf, low expression of Il1B, Il6 and Il1r2 and intermediate expression of other cytokines receptors. LPS treatment induced (P≤0.05) expression in all cytokines and their receptors, except Il6r 3h after the administration. Melatonin attenuated (P≤0.05) LPS-induced up-regulation of Il6 but had no effect on other cytokines and their receptors and up-regulated (P≤0.05) Rev.-erbα expression under basal conditions. This indicates that melatonin from slow-release implants suppresses TLR4-mediated Il6 expression in the ovine CP via a mechanism likely involving clock genes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Harsh Environment Gas Sensor Array for Venus Atmospheric Measurements, Phase II (United States)

    National Aeronautics and Space Administration — Makel Engineering and the Ohio State University propose to develop a harsh environment tolerant gas sensor array for atmospheric analysis in future Venus missions....

  7. Venus Interior Probe Using In-situ Power and Propulsion (VIP-INSPR), Phase II (United States)

    National Aeronautics and Space Administration — Venus, despite being our closest neighboring planet, is under-explored due to its hostile environment. The atmosphere is composed primarily of CO2, with a 92 bar...

  8. Venus Interior Probe Using In-Situ Power and Propulsion (VIP-INSPR) (United States)

    Bugga, Ratnakumar V.


    Venus, despite being our closest neighboring planet, is under-explored due to its hostile and extreme environment, with a 92 bar pressure and 467 C temperature at the surface. The temperature decreases at higher altitudes, almost at the rate of 7.9 C/km, reaching the Earth surface conditions at 65 km. Due to the less extreme conditions, balloon missions could survive as long as 46 h at an altitude of 54 km. However, because of the opacity of the Venus atmosphere filled with clouds of sulfuric acid and CO2, orbiter or balloon missions are not as revealing and informative in characterizing the surface, as similar missions on Moon and Mars. To understand the evolutionary paths of Venus in relation to Earth, it is imperative to gather basic information on the crust, mantle, core, atmosphere/exosphere and bulk composition of Venus, through in-situ investigations using landers, probes and variable altitude areal platforms.

  9. Studies of the atmosphere of Venus by means of spacecraft: Solved and unsolved problems (United States)

    Moroz, V. I.

    Many spacecraft were used for exploration of the atmosphere of Venus. Their list consists of 25 items, including fly-by missions, orbiters, descent and landing probes and even balloons. VENERA-4 (1967) was near the beginning of this list, providing the first time in situ experiments on other planet. It started a long sequence of successful Soviet Venera missions. However after the year 1985 there were no missions to Venus in Russia. It probably was a strategic error. Now several groups of scientists in other countries work on proposals for new missions to Venus. The goal of this paper is to present a brief review of already solved and still unsolved problems in the studies of the Venus' atmosphere and to possible future aims in this field.

  10. sarA negatively regulates Staphylococcus epidermidis biofilm formation by modulating expression of 1 MDa extracellular matrix binding protein and autolysis‐dependent release of eDNA

    DEFF Research Database (Denmark)

    Christner, Martin; Heinze, Constanze; Busch, Michael


    to biofilm formation in mutant 1585ΔsarA. Increased eDNA amounts indirectly resulted from upregulation of metalloprotease SepA, leading to boosted processing of autolysin AtlE, in turn inducing augmented autolysis and release of eDNA. Hence, this study identifies sarA as a negative regulator of Embp‐ and e...

  11. The Gastrin-Releasing Peptide Receptor as Target for Molecular Imaging of Prostate Cancer : GRPR expression in prostate cancer and targeting with Bombesin-like radiopharmaceuticals

    NARCIS (Netherlands)

    Ananias, Hildo


    Prostaatkanker is wereldwijd een veel voorkomende oorzaak van kanker, morbiditeit en sterfte. Nauwkeurige stagering is moeilijk en nog steeds suboptimaal. De Gastrin-Releasing Peptide Receptor (GRPR) is een tumor-geassocieerd antigeen dat tot overexpressie wordt gebracht in prostaatkanker. Gerichte

  12. The major surface glycoprotein of Pneumocystis carinii induces release and gene expression of interleukin-8 and tumor necrosis factor alpha in monocytes

    DEFF Research Database (Denmark)

    Benfield, T L; Lundgren, Bettina; Levine, S J


    Recent studies suggest that interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-alpha) may play a central role in host defense and pathogenesis during Pneumocystis carinii pneumonia. In order to investigate whether the major surface antigen (MSG) of human P. carinii is capable of eliciting...... the release of IL-8 and TNF-alpha, human monocytes were cultured in the presence of purified MSG. MSG-stimulated cells released significant amounts of IL-8 within 4 h, and at 20 h, cells stimulated with MSG released 45.5 +/- 9.3 ng of IL-8/ml versus 3.7 +/- 1.1 ng/ml for control cultures (P = 0.......01). In a similar fashion, MSG elicited release of TNF-alpha. Initial increases were also seen at 4 h, and at 20 h, TNF-alpha levels reached 6.4 +/- 1.1 ng/ml, compared to 0.08 +/- 0.01 ng/ml for control cultures (P alpha secretion was observed at 20 h...

  13. Peripheral administration of palmitoylated prolactin-releasing peptide induces Fos expression in hypothalamic neurons involved in energy homeostasis in NMRI male mice

    Czech Academy of Sciences Publication Activity Database

    Pirník, Zdenko; Železná, Blanka; Kiss, A.; Maletínská, Lenka


    Roč. 1625, Nov 2 (2015), s. 151-158 ISSN 0006-8993 R&D Projects: GA ČR(CZ) GA15-08679S Institutional support: RVO:61388963 Keywords : hypothalamus * prolactin-releasing peptide * Fos * oxytocin * hypocretin * mice Subject RIV: CE - Biochemistry Impact factor: 2.561, year: 2015

  14. On a predominant ionization source in the main maximum of the Venus nightside ionosphere

    International Nuclear Information System (INIS)

    Gringauz, K.I.; Verigin, M.I.; Breus, T.K.; Shvachunova, L.A.


    New considerations in favour of the previously made hypothesis, made on the basis of data using ''Venera-9 and 10'' satellites, that electron fluxes are the main ionization sources, creating the upper maximum of electron concentration in the night Venus atmosphere, are presented. Analysis of arguments, made by certain american authors, suggesting that O + ion transfer from the day Venus ionosphere to the night one should be considered as the main source of night ionization is made, and inconsistency of the argument shown

  15. Long-Lived Venus Lander Conceptual Design: How To Keep It Cool (United States)

    Dyson, Ridger W.; Schmitz, Paul C.; Penswick, L. Barry; Bruder, Geoffrey A.


    Surprisingly little is known about Venus, our neighboring sister planet in the solar system, due to the challenges of operating in its extremely hot, corrosive, and dense environment. For example, after over two dozen missions to the planet, the longest-lived lander was the Soviet Venera 13, and it only survived two hours on the surface. Several conceptual Venus mission studies have been formulated in the past two decades proposing lander architectures that potentially extend lander lifetime. Most recently, the Venus Science and Technology Definition Team (STDT) was commissioned by NASA to study a Venus Flagship Mission potentially launching in the 2020- 2025 time-frame; the reference lander of this study is designed to survive for only a few hours more than Venera 13 launched back in 1981! Since Cytherean mission planners lack a viable approach to a long-lived surface architecture, specific scientific objectives outlined in the National Science Foundation Decadal Survey and Venus Exploration Advisory Group final report cannot be completed. These include: mapping the mineralogy and composition of the surface on a planetary scale determining the age of various rock samples on Venus, searching for evidence of changes in interior dynamics (seismometry) and its impact on climate and many other key observations that benefit with time scales of at least a full Venus day (Le. daylight/night cycle). This report reviews those studies and recommends a hybrid lander architecture that can survive for at least one Venus day (243 Earth days) by incorporating selective Stirling multi-stage active cooling and hybrid thermoacoustic power.

  16. Venusians: the Planet Venus in the 18th-Century Extraterrestrial Life Debate (United States)

    Duner, David


    In the seventeenth and eighteenth centuries it became possible to believe in the existence of life on other planets on scientific grounds. Once the Earth was no longer the center of the universe according to Copernicus, once Galileo had aimed his telescope at the Moon and found it a rough globe with mountains and seas, the assumption of life on other planets became much less far-fetched. In general there were no actual differences between Earth and Venus, since both planets orbited the Sun, were of similar size, and possessed mountains and an atmosphere. If there is life on Earth, one may ponder why it could not also exist on Venus. In the extraterrestrial life debate of the seventeenth and eighteenth centuries, the Moon, our closest celestial body, was the prime candidate for life on other worlds, although a number of scientists and scholars also speculated about life on Venus and on other planets, both within our solar system and beyond its frontiers. This chapter discusses the arguments for life on Venus and those scientific findings that were used to support them, which were based in particular on assumptions and claims that both mountains and an atmosphere had been found on Venus. The transits of Venus in the 1760s became especially important for the notion that life could thrive on Venus. Here, I detect two significant cognitive processes that were at work in the search for life on Venus, i.e., analogical reasoning and epistemic perception, while analogies and interpretations of sensory impressions based on prior knowledge played an important role in astrobiological theories.

  17. VERITAS: a Discovery-Class Venus Surface Geology and Geophysics Mission (United States)

    Freeman, Anthony; Smrekar, Suzanne E.; Hensley, Scott; Wallace, Mark; Sotin, Christophe; Darrach, Murray; Xaypraseuth, Peter; Helbert, Joern; Mazarico, Erwan


    Our understanding of solar system evolution is limited by a great unanswered question: How Earthlike is Venus? We know that these "twin" planets formed with similar bulk composition and size. Yet the evolutionary path Venus followed has diverged from Earth's, in losing its surface water and becoming hotter than Mercury. What led to this? The answer has profound implications for how terrestrial planets become habitable and the potential for life in the universe.

  18. Venus thermosphere and exosphere - First satellite drag measurements of an extraterrestrial atmosphere (United States)

    Keating, G. M.; Tolson, R. H.; Hinson, E. W.


    Atmospheric drag measurements obtained from the study of the orbital decay of Pioneer Venus I indicate that atomic oxygen predominates in the Venus atmosphere above 160 kilometers. Drag measurements give evidence that conditions characteristic of a planetary thermosphere disappear near sundown, with inferred exospheric temperatures sharply dropping from approximately 300 K to less than 150 K. Observed densities are generally lower than given by theoretical models.

  19. Candidate Earth Entry Trajectories to Mimic Venus Aerocapture Using a Lifting ADEPT (United States)

    Williams, Jimmy


    A Lifting ADEPT is considered for aerocapture at Venus. Analysis concerning the heating environment leads to an initial sizing estimate. In tandem, a direct entry profile at Earth is considered to act as a facsimile for the Venus aerocapture heating environment. The bounds of this direct entry profile are determined and it is found that a trajectory from a Geostationary Transfer Orbit with a Lifting ADEPT capable of fitting on a rideshare opportunity is capable of matching certain aspects of this heating environment.

  20. Reexamination of plasma measurements from the Mariner 5 Venus encounter

    International Nuclear Information System (INIS)

    Shefer, R.E.; Lazarus, A.J.; Bridge, H.S.


    Mariner 5 plasma data from the Venus encounter have been analyzed with twice the time resolution of the original analysis of Bridge et al. (1967). The velocity distribution function for each spectrum is used to determine more precisely the locations of boundaries and characteristic flow parameters in the interaction region around the planet. We identify a new region in the flow located between magnetosheathlike plasma inside the shock front and an interior low-flux region near the geometrical shadow of the planet. The region is characterized by a wide velocity distribution function and a decrease in ion flux. Using the highest time resolution magnetic field data made available by Smith et al., we propose that rapid magnetic field fluctuations in this region may result in an artificial broadening of the distribution function. We conclude that very high time resolution is required in future experiments in order to determine the true nature of the plasma in this region

  1. "Chiriguano" Astronomy - Venus and a Guarani New Year (United States)

    Pereira, Gonzalo

    A Supreme Decree emitted by the government of Bolivia instituted the celebration of the June solstices in view of the fact that the indigenous people, both the Andean highlands and the Amazon and Chaco, "have commemorated this event for thousands of years" (Gobierno del Estado Plurinacional de Bolivia, Decreto Supremo N° 0173, June16, 2009, La Paz). In the case of the lowlands' indigenous, particularly the Guarani people, the decree mentions the planet Venus as the argument for this celebration. In this case of study and in light of astronomical and ethnographic evidence, we analyze the relevance of this decree in the case of the Guarani people of the Bolivian Chaco region, known as "Chiriguanos".

  2. New maps of Lakshmi Planum and eastern Aphrodite, Venus (United States)

    Mcgill, G. E.


    Interest on Venus has centered on three regions; (1) Aphrodite Terra, especially east of the main uplant portion, (2) Ishtar Terra, especially Lakshmi Planum and its bounding scarp and massifs, and (3) Beta Regio-Phoebe Regio. The last region is topographically similar to the East African rift system, and has been inferred to have a similar tectonic origin. The Aphrodite region is part of a 21,000 km long tectonic zone that seems best explained as due to extension, and that may represent hot spots clustered along an incipient divergent plate boundary. The most interesting and complex portion of this tectonic zone is that part of eastern Aphrodite between Thetis Regio and Atla Regio. In contrast, the Lakshmi Planum region has many topographic characteristics suggesting that it is a true continent, and thus indicative of convergence and a thick crust. Detailed topographic contour maps of eastern Aphrodite Terra and of Lakshmi Planum are included.

  3. Clementine Observes the Moon, Solar Corona, and Venus (United States)


    In 1994, during its flight, the Clementine spacecraft returned images of the Moon. In addition to the geologic mapping cameras, the Clementine spacecraft also carried two Star Tracker cameras for navigation. These lightweight (0.3 kg) cameras kept the spacecraft on track by constantly observing the positions of stars, reminiscent of the age-old seafaring tradition of sextant/star navigation. These navigation cameras were also to take some spectacular wide angle images of the Moon.In this picture the Moon is seen illuminated solely by light reflected from the Earth--Earthshine! The bright glow on the lunar horizon is caused by light from the solar corona; the sun is just behind the lunar limb. Caught in this image is the planet Venus at the top of the frame.

  4. Venus atmosphere profile from a maximum entropy principle

    Directory of Open Access Journals (Sweden)

    L. N. Epele


    Full Text Available The variational method with constraints recently developed by Verkley and Gerkema to describe maximum-entropy atmospheric profiles is generalized to ideal gases but with temperature-dependent specific heats. In so doing, an extended and non standard potential temperature is introduced that is well suited for tackling the problem under consideration. This new formalism is successfully applied to the atmosphere of Venus. Three well defined regions emerge in this atmosphere up to a height of 100 km from the surface: the lowest one up to about 35 km is adiabatic, a transition layer located at the height of the cloud deck and finally a third region which is practically isothermal.

  5. Comparative kinematical analyses of Venus flytrap (Dionaea muscipula snap traps

    Directory of Open Access Journals (Sweden)

    Simon Poppinga


    Full Text Available Although the Venus flytrap (Dionaea muscipula can be considered as one of the most extensively investigated carnivorous plants, knowledge is still scarce about diversity of the snap-trap motion, the functionality of snap traps under varying environmental conditions, and their opening motion. By conducting simple snap-trap closure experiments in air and under water, we present striking evidence that adult Dionaea snaps similarly fast in aerial and submersed states and, hence, is potentially able to gain nutrients from fast aquatic prey during seasonal inundation. We reveal three snapping modes of adult traps, all incorporating snap buckling, and show that millimeter-sized, much slower seedling traps do not yet incorporate such elastic instabilities. Moreover, opening kinematics of young and adult Dionaea snap traps reveal that reverse snap buckling is not performed, corroborating the assumption that growth takes place on certain trap lobe regions. Our findings are discussed in an evolutionary, biomechanical, functional–morphological and biomimetic context.

  6. Tectonics of Lakshmi Planum, Venus: Tests for Magellan

    International Nuclear Information System (INIS)

    Grimm, R.E.; Phillips, R.J.


    The origin of Lakshmi Planum and its surrounding mountain belts remains an important unresolved element in the global tectonic framework of Venus. From the perspective of gravity signature and potential driving forces, the mantle upwelling model is the simplest and its principal failure, that it cannot produce radial shortening on the uplift periphery, may be resolved if the lithosphere is laterally heterogeneous. The preferred model consists of a hot mantle plume rising beneath a pre-existing block of tessera. The lithosphere is weakened at this hotter and presumably thicker crust, and the outward near-surface flow is attenuated at the peripheral discontinuity in lithospheric strength. Crustal thickening and mountain belt formation occur there. The authors propose several criteria to test this tessera-plume model together with its competitors at the higher resolution in both imaging and gravity afforded by the Magellan mission

  7. Canali-type channels on Venus - Some genetic constraints (United States)

    Komatsu, Goro; Kargel, Jeffrey S.; Baker, Victor R.


    Canali-type channels on Venus are unique because of their great lengths (up to 6800 km) and nearly constant channel cross sectional shapes along their paths. A simple model incorporating channel flow and radiative cooling suggests that common terrestrial-type tholeiite lava cannot sustain a superheated and turbulent state for the long distances required for thermal erosion of canali within allowable discharge rates. If canali formed mainly by constructional processes, laminar tholeiitic flow of relatively high, sustained discharge rates might travel the observed distances, but the absence of levees would need to be explained. An exotic low temperature, low viscosity lava like carbonatite or sulfur seems to be required for the erosional genesis of canali.

  8. Selective expression of the type 3 isoform of ryanodine receptor Ca2+ release channel (RyR3) in a subset of slow fibers in diaphragm and cephalic muscles of adult rabbits

    International Nuclear Information System (INIS)

    Conti, Antonio; Reggiani, Carlo; Sorrentino, Vincenzo


    The expression pattern of the RyR3 isoform of Ca 2+ release channels was analysed by Western blot in neonatal and adult rabbit skeletal muscles. The results obtained show that the expression of the RyR3 isoform is developmentally regulated. In fact, RyR3 expression was detected in all muscles analysed at 2 and 15 days after birth while, in adult animals, it was restricted to a subset of muscles that includes diaphragm, masseter, pterygoideus, digastricus, and tongue. Interestingly, all of these muscles share a common embryonic origin being derived from the somitomeres or from the cephalic region of the embryo. Immunofluorescence analysis of rabbit skeletal muscle cross-sections showed that RyR3 staining was detected in all fibers of neonatal muscles. In contrast, in those adult muscles expressing RyR3 only a fraction of fibers was labelled. Staining of these muscles with antibodies against fast and slow myosins revealed a close correlation between expression of RyR3 and fibers expressing slow myosin isoform

  9. Geologic Map of the Greenaway Quadrangle (V-24), Venus (United States)

    Lang, Nicholas P.; Hansen, Vicki L.


    The Greenaway quadrangle (V-24; lat 0 degrees -25 degrees N., long 120 degrees -150 degrees E.), Venus, derives its name from the impact crater Greenaway, centered at lat 22.9 degrees N., long 145.1 degrees E., in the northeastern part of the quadrangle. Greenaway was a well-noted writer and illustrator of children`s books in Britain during the nineteenth century. In Greenaway`s honor, the Library Association of Great Britain presents the annual Kate Greenaway Medal to an illustrator living and publishing in Britain who has produced the most distinguished children`s book illustrations for that year. The Greenaway quadrangle occupies an 8,400,000 km2 equatorial swath of lowlands and highlands. The map area is bounded by the crustal plateau, Thetis Regio, to the south and Gegute Tessera to the west. The rest of the quadrangle consists of part of Llorona Planitia, which is part of the vast lowlands that cover about 80 percent of Venus` surface. The southern map area marks the north edge of Aphrodite Terra, including Thetis Regio, that includes the highest topography in the quadrangle with elevations reaching >1 km above the Mean Planetary Radius (MPR; 6,051.84 km). Northern Aphrodite Terra abruptly slopes north to Llorona Planitia. A broad northeast-trending topographic arch pocked with coronae separates two northeast-trending elongate basins, Llorona Planitia on the east, that form depositional centers for shield and coronae-sourced materials; both basins drop to elevations of history for this region, which in turn provides insights into volcanic and tectonic processes that shaped the Venusian surface. Map relations illustrate that aerially expansive shield terrain (unit st) played a primary role and coronae played a secondary role in volcanic resurfacing across the map area.

  10. An Atmospheric Variability Model for Venus Aerobraking Missions (United States)

    Tolson, Robert T.; Prince, Jill L. H.; Konopliv, Alexander A.


    Aerobraking has proven to be an enabling technology for planetary missions to Mars and has been proposed to enable low cost missions to Venus. Aerobraking saves a significant amount of propulsion fuel mass by exploiting atmospheric drag to reduce the eccentricity of the initial orbit. The solar arrays have been used as the primary drag surface and only minor modifications have been made in the vehicle design to accommodate the relatively modest aerothermal loads. However, if atmospheric density is highly variable from orbit to orbit, the mission must either accept higher aerothermal risk, a slower pace for aerobraking, or a tighter corridor likely with increased propulsive cost. Hence, knowledge of atmospheric variability is of great interest for the design of aerobraking missions. The first planetary aerobraking was at Venus during the Magellan mission. After the primary Magellan science mission was completed, aerobraking was used to provide a more circular orbit to enhance gravity field recovery. Magellan aerobraking took place between local solar times of 1100 and 1800 hrs, and it was found that the Venusian atmospheric density during the aerobraking phase had less than 10% 1 sigma orbit to orbit variability. On the other hand, at some latitudes and seasons, Martian variability can be as high as 40% 1 sigmaFrom both the MGN and PVO mission it was known that the atmosphere, above aerobraking altitudes, showed greater variability at night, but this variability was never quantified in a systematic manner. This paper proposes a model for atmospheric variability that can be used for aerobraking mission design until more complete data sets become available.

  11. The photochemical stability of the Venus atmosphere against UV radiation

    International Nuclear Information System (INIS)

    Mills, F.P.; Slanger, T.G.; Allen, M.


    Full text: One unresolved question regarding the Venus atmosphere is what chemical mechanism(s) stabilize its primary constituent (CO 2 ) against UV radiation. CO 2 photolyzes on the day side into CO and O after absorbing photons at 2 rather than recombining with CO to form CO 2 , and the intense night side O 2 airglow observed quantitatively supports this. CO and O 2 are photochemically stable in an otherwise pure CO 2 atmosphere so significant abundances of CO and O 2 could accumulate on Venus if no catalytic mechanism existed to speed the reformation of CO 2 . However, the observational upper limit on ground state O 2 is equivalent to 2 from CO and O 2 . Recent laboratory work verified the existence of the ClC(O)OO catalytic mechanism that has been used in photochemical models since the early 1980s. However, there are significant uncertainties in the rates for the component steps of this catalytic mechanism. An alternative mechanism for production of CO 2 that has not previously been modeled but which could be competitive with the ClCO(O)O mechanism is the reaction CO + O 2 (c 1 Σ - u ) → CO 2 + O( 1 D) or O( 1 S), Reaction (1). A range of values for Reaction (1) will be examined in model calculations to compare with observational (UV to IR) constraints and to assess under what conditions this mechanism is competitive with the ClC(O)OO catalytic mechanism. The sensitivity of the results to uncertainties in the CO 2 UV absorption cross section also will be examined

  12. Magellan radio occultation measurements of atmospheric waves on Venus (United States)

    Hinson, David P.; Jenkins, J. M.


    Radio occultation experiments were conducted at Venus on three consecutive orbits of the Magellan spacecraft in October 1991. Each occultation occurred over the same topography (67 deg N, 127 deg E) and at the same local time (22 hr 5 min), but the data are sensitive to zonal variations because the atmosphere rotates significantly during one orbit. Through comparisons between observations and predictions of standard wave theory, we have demonstrated that small-scale oscillations in retrieved temperature profiles as well as scintillations in received signal intensity are caused by a spectrum of vertically propagating internal gravity waves. There is a strong similarity between the intensity scintillations observed here and previous measurements, which pertain to a wide range of locations and experiment dates. This implies that the same basic phenomenon underlies all the observations and hence that gravity waves are a persistent, global feature of Venus' atmosphere. We obtained a fairly complete characterization of a gravity wave that appears above the middle cloud in temperature measurements on all three orbits. The amplitude and vertical wavelength are about 4 K and 2.5 km respectively, at 65 km. A model for radiative damping implies that the wave intrinsic frequency is approximately 2 x 10(exp 4) rad/sec, the corresponding ratio between horizontal and vertical wavelengths is approximately 100. The wave is nearly stationary relative to the surface or the Sun. Radiative attenuation limits the wave amplitude at altitudes above approximately 65 km, leading to wave drag on the mean zonal winds of about +0.4 m/sec per day (eastward). The sign, magnitude, and location of this forcing suggest a possible role in explaining the decrease with height in the zonal wind speed that is believed to occur above the cloud tops. Temperature oscillations with larger vertical wavelengths (5-10 km) were also observed on all three orbits, but we are able unable to interpret these

  13. The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake. (United States)

    Böhm, Jennifer; Scherzer, Sönke; Krol, Elzbieta; Kreuzer, Ines; von Meyer, Katharina; Lorey, Christian; Mueller, Thomas D; Shabala, Lana; Monte, Isabel; Solano, Roberto; Al-Rasheid, Khaled A S; Rennenberg, Heinz; Shabala, Sergey; Neher, Erwin; Hedrich, Rainer


    Carnivorous plants, such as the Venus flytrap (Dionaea muscipula), depend on an animal diet when grown in nutrient-poor soils. When an insect visits the trap and tilts the mechanosensors on the inner surface, action potentials (APs) are fired. After a moving object elicits two APs, the trap snaps shut, encaging the victim. Panicking preys repeatedly touch the trigger hairs over the subsequent hours, leading to a hermetically closed trap, which via the gland-based endocrine system is flooded by a prey-decomposing acidic enzyme cocktail. Here, we asked the question as to how many times trigger hairs have to be stimulated (e.g., now many APs are required) for the flytrap to recognize an encaged object as potential food, thus making it worthwhile activating the glands. By applying a series of trigger-hair stimulations, we found that the touch hormone jasmonic acid (JA) signaling pathway is activated after the second stimulus, while more than three APs are required to trigger an expression of genes encoding prey-degrading hydrolases, and that this expression is proportional to the number of mechanical stimulations. A decomposing animal contains a sodium load, and we have found that these sodium ions enter the capture organ via glands. We identified a flytrap sodium channel DmHKT1 as responsible for this sodium acquisition, with the number of transcripts expressed being dependent on the number of mechano-electric stimulations. Hence, the number of APs a victim triggers while trying to break out of the trap identifies the moving prey as a struggling Na(+)-rich animal and nutrition for the plant. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. Protein alterations induced by long-term agonist treatment of HEK293 cells expressing thyrotropin-releasing hormone receptor and G11alpha protein

    Czech Academy of Sciences Publication Activity Database

    Drastichová, Z.; Bouřová, Lenka; Hejnová, L.; Jedelský, P.; Svoboda, Petr; Novotný, J.


    Roč. 109, č. 1 (2010), s. 255-264 ISSN 0730-2312 R&D Projects: GA MŠk(CZ) LC554; GA ČR(CZ) GA309/06/0121; GA ČR(CZ) GD305/08/H037 Institutional research plan: CEZ:AV0Z50110509 Keywords : Thyrotropin-releasing hormone * Gq/11 protein * proteomics Subject RIV: ED - Physiology Impact factor: 3.122, year: 2010

  15. Aplikasi Dua Segitiga Sebangun pada Studi Venus Transit di Matahari Tanggal 8 Juni 2004 dari BPD LAPAN Watukosek

    Directory of Open Access Journals (Sweden)

    Nanang Widodo


    Full Text Available Transit planet Venus di cakram matahari (jari-jari = 696000 km merupakan peristiwa alam yang dapat dilihat secara berkala. Planet Venus merupakan planet kedua dalam sistem tata surya yang mempunyai orbit lebih dekat ke matahari (= 0,723 Astronomical Unit dibanding jarak bumi-matahari (= 149.600.000 km = 1 AU. Sehingga pada suatu waktu tertentu ada peluang berada tepat di depan Bumi, saat menghadap matahari atau dikenal dengan transit Venus. Proses pengamatan fenomena transit Venus di cakram matahari tersebut dapat diimplimentasikan sebagai aplikasi dua segitiga sebangun, Dimana jari-jari planet Venus (jari-jari = 6051,8 km dinyatakan sebagai tinggi benda dan jari-jari tinggi bayangan Venus sebesar 20880 km (= 3,65 mm pada cakram matahari. Dimana diameter matahari 1.392.000 km (= 240 mm pada lembar sket. Dengan pengukuran jarak tempuh Venus transit 72,4 mm (419 920 km di cakram matahari terhadap waktu kontak pertama bayangan Venus pada jam 05.28 UT (12.28 WIB di tepi timur hingga akhir transit pada 17.50 UT (14.50 WIB diperoleh kecepatan bayangan Venus sebesar 49,286 km/detik

  16. Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HβD2 gene expression and IL-8 release.

    Directory of Open Access Journals (Sweden)

    Lisa B Davidson

    Full Text Available Mycobacterium abscessus has emerged as an important cause of lung infection, particularly in patients with bronchiectasis. Innate immune responses must be highly effective at preventing infection with M. abscessus because it is a ubiquitous environmental saprophyte and normal hosts are not commonly infected. M. abscessus exists as either a glycopeptidolipid (GPL expressing variant (smooth phenotype in which GPL masks underlying bioactive cell wall lipids, or as a variant lacking GPL which is immunostimulatory and invasive in macrophage infection models. Respiratory epithelium has been increasingly recognized as playing an important role in the innate immune response to pulmonary pathogens. Respiratory epithelial cells express toll-like receptors (TLRs which mediate the innate immune response to pulmonary pathogens. Both interleukin-8 (IL-8 and human β-defensin 2 (HβD2 are expressed by respiratory epithelial cells in response to toll-like receptor 2 (TLR2 receptor stimulation. In this study, we demonstrate that respiratory epithelial cells respond to M. abscessus variants lacking GPL with expression of IL-8 and HβD2. Furthermore, we demonstrate that this interaction is mediated through TLR2. Conversely, M. abscessus expressing GPL does not stimulate expression of IL-8 or HβD2 by respiratory epithelial cells which is consistent with "masking" of underlying bioactive cell wall lipids by GPL. Because GPL-expressing smooth variants are the predominant phenotype existing in the environment, this provides an explanation whereby initial M. abscessus colonization of abnormal lung airways escapes detection by the innate immune system.

  17. Stability of Basalt plus Anhydrite plus Calcite at HP-HT: Implications for Venus, the Earth and Mars (United States)

    Martin, A. M.; Righter, K.; Treiman, A. H.


    "Canali" observed at Venus surface by Magellan are evidence for very long melt flows, but their composition and origin remain uncertain. The hypothesis of water-rich flow is not reasonable regarding the temperature at Venus surface. The length of these channels could not be explained by a silicate melt composition but more likely, by a carbonate-sulfate melt which has a much lower viscosity (Kargel et al 1994). One hypothesis is that calcite CaCO3 and anhydrite CaSO4 which are alteration products of basalts melted during meteorite impacts. A famous example recorded on the Earth (Chicxulub) produced melt and gas rich in carbon and sulfur. Calcite and sulfate evaporites are also present on Mars surface, associated with basalts. An impact on these materials might release C- and S-rich melt or fluid. Another type of planetary phenomenon (affecting only the Earth) might provoke a high pressure destabilization of basalt+anhydrite+calcite. Very high contents of C and S are measured in some Earth s magmas, either dissolved or in the form of crystals (Luhr 2008). As shown by the high H content and high fO2 of primary igneous anhydrite-bearing lavas, the high S content in their source may be explained by subduction of an anhydrite-bearing oceanic crust, either directly (by melting followed by eruption) or indirectly (by release of S-rich melt or fluid that metasomatize the mantle) . Calcite is a major product of oceanic sedimentation and alteration of the crust. Therefore, sulfate- and calcite-rich material may be subducted to high pressures and high temperatures (HP-HT) and release S- and C-rich melts or fluids which could influence the composition of subduction zone lavas or gases. Both phenomena - meteorite impact and subduction - imply HP-HT conditions - although the P-T-time paths are different. Some HP experimental/theoretical studies have been performed on basalt/eclogite, calcite and anhydrite separately or on a combination of two. In this study we performed piston

  18. Corticotropin-Releasing Hormone (CRH Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1.

    Directory of Open Access Journals (Sweden)

    Wonkyoung Cho

    Full Text Available Atherosclerosis, the major pathology of cardiovascular disease, is caused by multiple factors involving psychological stress. Corticotropin-releasing hormone (CRH, which is released by neurosecretory cells in the hypothalamus, peripheral nerve terminals and epithelial cells, regulates various stress-related responses. Our current study aimed to verify the role of CRH in macrophage foam cell formation, the initial critical stage of atherosclerosis. Our quantitative real-time reverse transcriptase PCR (qRT-PCR, semi-quantitative reverse transcriptase PCR, and Western blot results indicate that CRH down-regulates ATP-binding cassette transporter-1 (ABCA1 and liver X receptor (LXR-α, a transcription factor for ABCA1, in murine peritoneal macrophages and human monocyte-derived macrophages. Oil-red O (ORO staining and intracellular cholesterol measurement of macrophages treated with or without oxidized LDL (oxLDL and with or without CRH (10 nM in the presence of apolipoprotein A1 (apoA1 revealed that CRH treatment promotes macrophage foam cell formation. The boron-dipyrromethene (BODIPY-conjugated cholesterol efflux assay showed that CRH treatment reduces macrophage cholesterol efflux. Western blot analysis showed that CRH-induced down-regulation of ABCA1 is dependent on phosphorylation of Akt (Ser473 induced by interaction between CRH and CRH receptor 1(CRHR1. We conclude that activation of this pathway by CRH accelerates macrophage foam cell formation and may promote stress-related atherosclerosis.

  19. A second corticotropin-releasing hormone gene (CRH2) is conserved across vertebrate classes and expressed in the hindbrain of a basal neopterygian fish, the spotted gar (Lepisosteus oculatus). (United States)

    Grone, Brian P; Maruska, Karen P


    To investigate the origins of the vertebrate stress-response system, we searched sequenced vertebrate genomes for genes resembling corticotropin-releasing hormone (CRH). We found that vertebrate genomes possess, in addition to CRH, another gene that resembles CRH in sequence and syntenic environment. This paralogous gene was previously identified only in the elephant shark (a holocephalan), but we find it also in marsupials, monotremes, lizards, turtles, birds, and fishes. We examined the relationship of this second vertebrate CRH gene, which we name CRH2, to CRH1 (previously known as CRH) and urocortin1/urotensin1 (UCN1/UTS1) in primitive fishes, teleosts, and tetrapods. The paralogs CRH1 and CRH2 likely evolved via duplication of CRH during a whole-genome duplication early in the vertebrate lineage. CRH2 was subsequently lost in both teleost fishes and eutherian mammals but retained in other lineages. To determine where CRH2 is expressed relative to CRH1 and UTS1, we used in situ hybridization on brain tissue from spotted gar (Lepisosteus oculatus), a neopterygian fish closely related to teleosts. In situ hybridization revealed widespread distribution of both crh1 and uts1 in the brain. Expression of crh2 was restricted to the putative secondary gustatory/secondary visceral nucleus, which also expressed calcitonin-related polypeptide alpha (calca), a marker of parabrachial nucleus in mammals. Thus, the evolutionary history of CRH2 includes restricted expression in the brain, sequence changes, and gene loss, likely reflecting release of selective constraints following whole-genome duplication. The discovery of CRH2 opens many new possibilities for understanding the diverse functions of the CRH family of peptides across vertebrates. © 2015 Wiley Periodicals, Inc.

  20. Geologic Map of the Lavinia Planitia Quadrangle (V-55), Venus (United States)

    Ivanov, Mikhail A.; Head, James W.


    Introduction The Lavinia Planitia quadrangle (V-55) is in the southern hemisphere of Venus and extends from 25 to 50 south latitude and from 330 to 360 longitude. It covers the central and northern part of Lavinia Planitia and parts of its margins. Lavinia Planitia consists of a centralized, deformed lowland flooded by volcanic deposits and surrounded by Dione Regio to the west (Keddie and Head, 1995), Alpha Regio tessera (Bindschadler and others, 1992a) and Eve Corona (Stofan and others, 1992) to the northeast, itself an extensive rift zone and coronae belt to the east and south (Baer and others, 1994; Magee and Head, 1995), Mylitta Fluctus to the south (Magee Roberts and others, 1992), and Helen Planitia to the southwest (Senske and others, 1991). In contrast to other areas on Venus, the Lavinia Planitia area is one of several large, relatively equidimensional lowlands (basins) and as such is an important region for the analysis of processes of basin formation and volcanic flooding. Before the Magellan mission, Lavinia Planitia was known on the basis of Pioneer-Venus altimetry to be a lowland area (Pettengill and others, 1980);. Arecibo radar images showed that Lavinia Plaitia was surrounded by several corona-like features and rift-like fractures parallel to the basin margin to the east and south (Senske and others, 1991; Campbell and others, 1990). Arecibo data further revealed that the interior contained complex patterns of deformational features in the form of belts and volcanic plains, and several regions along the margins were seen to be the sources of extensive outpourings of digitate lava flows into the interior (Senske and others, 1991; Campbell and others, 1990). Early Magellan results showed that the ridge belts are composed of complex structures of both extensional and contractional origin (Squyres and others, 1992; Solomon and others, 1992) and that the complex lava flows (fluctus) along the margins (Magee Roberts and others, 1992) emanated from a

  1. Increased expression of tyrosine hydroxylase immunoreactivity in paraventricular and supraoptic neurons in illnesses with prolonged osmotic or nonosmotic stimulation of vasopressin release

    NARCIS (Netherlands)

    Panayotacopoulou, Maria T.; Malidelis, Yiannis I.; Fliers, Eric; Bouras, Constantin; Ravid, Rivka; Swaab, Dick F.


    Our previous studies indicated that in the human para-ventricular (PVN) and supraoptic (SON) nuclei, tyrosine hydroxylase (TH) - the first and rate-limiting enzyme in catecholamine synthesis - is localized mainly in magnocellular neurons and that antemortem factors regulate its expression. The

  2. Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells

    DEFF Research Database (Denmark)

    Friedrichsen, B N; Carlsson, C; Møldrup, Annette


    Preadipocyte factor-1 (Pref-1)/delta-like protein/fetal antigen-1 (FA1) is a member of the epidermal growth factor-like family. It is widely expressed in embryonic tissues, whereas in adults it is confined to the adrenal gland, the anterior pituitary, the endocrine pancreas, the testis...

  3. Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism

    DEFF Research Database (Denmark)

    Grunddal, Kaare Villum; Ratner, Cecilia F; Svendsen, Berit


    increasingly multi-hormonal, i.e. co-expressing PYY and neurotensin as they move up the villus. Pro-glucagon promoter and pertussis toxin receptor driven cell ablation and reappearance studies indicated that although all the cells die, the GLP-1 cells reappear more quickly than PYY and neurotensin positive...

  4. The glucagon-like peptide 1 analogue Exendin-4 attenuates the nicotine-induced locomotor stimulation, accumbal dopamine release, conditioned place preference as well as the expression of locomotor sensitization in mice.

    Directory of Open Access Journals (Sweden)

    Emil Egecioglu

    Full Text Available The gastrointestinal peptide glucagon-like peptide 1 (GLP-1 is known to regulate consummatory behavior and is released in response to nutrient ingestion. Analogues of this peptide recently emerged as novel pharmacotherapies for treatment of type II diabetes since they reduce gastric emptying, glucagon secretion as well as enhance glucose-dependent insulin secretion. The findings that GLP-1 targets reward related areas including mesolimbic dopamine areas indicate that the physiological role of GLP-1 extends beyond food intake and glucose homeostasis control to include reward regulation. The present series of experiments was therefore designed to investigate the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4, on established nicotine-induced effects on the mesolimbic dopamine system in mice. Specifically, we show that treatment with Ex4, at a dose with no effect per se, attenuate nicotine-induced locomotor stimulation, accumbal dopamine release as well as the expression of conditioned place preference in mice. In accordance, Ex4 also blocks nicotine-induced expression of locomotor sensitization in mice. Given that development of nicotine addiction largely depends on the effects of nicotine on the mesolimbic dopamine system these findings indicate that the GLP-1 receptor may be a potential target for the development of novel treatment strategies for nicotine cessations in humans.

  5. Protective effects of methanolic extract of Adhatoda vasica Nees leaf in collagen-induced arthritis by modulation of synovial toll-like receptor-2 expression and release of pro-inflammatory mediators

    Directory of Open Access Journals (Sweden)

    Rana Adhikary


    Full Text Available RA associated with oxidative stress and chronic inflammation has been a major health problem among the population worldwide. In this study protective effect of methanolic extract of Adhatoda vasica leaf (AVE was evaluated on Collagen-induced arthritis in male Swiss albino mice. Post oral administration of AVE at 50, 100 and 200 mg/kg body weight doses decreased the arthritic index and footpad swelling. AVE administration diminished pro-inflammatory cytokines in serum and synovial tissues. Reduced chemokines and neutrophil infiltration in synovial tissues after AVE administration dictated its protective effect against RA. Decreased LPO content and SOD activity along with concomitant rise in GSH and CAT activities from liver, spleen and synovial tissues indicated regulation of oxidative stress by AVE. In addition decreased CRP in serum along with suppressed TLR-2 expression in CIA mice after AVE treatment was also observed. Protective effect of AVE in RA is further supported from histopathological studies which showed improvement during bone damage. In conclusion this study demonstrated A. vasica is capable of regulating oxidative stress during CIA and therefore down regulated local and systemic release of pro-inflammatory mediators, which might be linked to mechanism of decreasing synovial TLR-2 expression via downregulating release of its regular endogenous ligands like CRP.

  6. Life in the Clouds of Venus? An Experimental Synthetic Biology Approach (United States)

    Rothschild, L. J.; Paulino-Lima, I. G.; Amatya, D.; Bajar, B.; Geilich, B.; Hu, J.; Jackson, C. J.


    The surface of Venus constitutes the most hellish and biologically inhospitable planetary surface in our solar system, boasting a pH of 0, blistering winds that can melt lead, and pressures of 60 atm. However, during the earlier years of the solar system, without the runaway greenhouse effect that has plagued the planet, Venus potentially housed oceans and perhaps even life. There is a possibility that microbes could have retreated into hospitable niches in the atmosphere, as suggested by Carl Sagan as early as 1967 [1]. For example, 50 km above the raging hell of the Venusian surface, exists a relatively temperate environment that might serve as reservoir for life. This astrobiology project seeks to explore life at the extremes and to theorize whether microbial communities could not only survive but also reproduce in the Venusian atmosphere. Specifically, we ask: are aerosols viable microbial environments? But before we can test for life in the clouds, we have to develop a proper reporter to visualize cell growth in situ. For this purpose, we aimed to develop cell-growth dependent reporters to serve as remote biosensors for cell growth. We developed two using the polA promoter, a DNA-replication dependent promoter, and nrd operon promoter, a cell-cycle dependent promoter. Using these cell-growth reporters, the next step is to aerosolize microbes expressing these reporters in a suspension chamber adapted from a Millikan Drop Apparatus to assay reproduction in an aerosolized environment. Better yet is to test the reproduction of microbes in a microgravity regime such as on ISS.Approach: We engineered two cell-cycle dependent genetic reporters. One was the polA promoter which codes for DNA Polymerase I, a gene active in DNA replication [2]. The other was the nrdP. The activation of ribonucleotide reductase reduces ribonucleotides into deoxyribonucleotides and is involved in the bacterial cell cycle [3]. This promoter began activation during the initiation of DNA

  7. Contrasting expressions of aggressive behavior released by lesions of the central nucleus of the amygdala during wakefulness and rapid eye movement sleep without atonia in cats. (United States)

    Zagrodzka, J; Hedberg, C E; Mann, G L; Morrison, A R


    Whether damage to the central nucleus of the amygdala (Ace) contributes to the predatorylike attack sometimes observed in rapid eye movement sleep without atonia (REM-A), created in cats by bilateral pontine lesions, was examined. Such lesions eliminate REM sleep skeletal muscle atonia and release elaborate behavior. Unilateral damage to the Ace alone increased affective defensive aggressive behavior toward humans and conspecifics without altering predatory behavior in wakefulness. Pontine lesions added at loci normally not leading to aggression induced predatorylike attacks in REM-A as well as the waking affective defense. Alterations of autonomic activity, the absence of relevant environmental stimuli in REM-A, or both may explain the state-related differences.

  8. Automated cloud tracking system for the Akatsuki Venus Climate Orbiter data (United States)

    Ogohara, Kazunori; Kouyama, Toru; Yamamoto, Hiroki; Sato, Naoki; Takagi, Masahiro; Imamura, Takeshi


    Japanese Venus Climate Orbiter, Akatsuki, is cruising to approach to Venus again although its first Venus orbital insertion (VOI) has been failed. At present, we focus on the next opportunity of VOI and the following scientific observations.We have constructed an automated cloud tracking system for processing data obtained by Akatsuki in the present study. In this system, correction of the pointing of the satellite is essentially important for improving accuracy of the cloud motion vectors derived using the cloud tracking. Attitude errors of the satellite are reduced by fitting an ellipse to limb of an imaged Venus disk. Next, longitude-latitude distributions of brightness (cloud patterns) are calculated to make it easy to derive the cloud motion vectors. The grid points are distributed at regular intervals in the longitude-latitude coordinate. After applying the solar zenith correction and a highpass filter to the derived longitude-latitude distributions of brightness, the cloud features are tracked using pairs of images. As a result, we obtain cloud motion vectors on longitude-latitude grid points equally spaced. These entire processes are pipelined and automated, and are applied to all data obtained by combinations of cameras and filters onboard Akatsuki. It is shown by several tests that the cloud motion vectors are determined with a sufficient accuracy. We expect that longitude-latitude data sets created by the automated cloud tracking system will contribute to the Venus meteorology.

  9. Investigating the Origin and Evolution of Venus with in Situ Mass Spectrometry (United States)

    Trainer, M. G.; Mahaffy, P. R.; Brinckerhoff, W. B.; Johnson, N. M.; Glaze, L. S.


    The exploration of Venus continues to be a top priority of planetary science. The Planetary Decadal Survey goals for inner-planet exploration seek to discern the origin and diversity of terrestrial planets, understand how the evolution of terrestrial planets relates to the evolution of life, and explore the processes that control climate on Earth-like planets. These goals can only be realized through continued and extensive exploration of Venus, the most mysterious of the terrestrial planets, remarkably different from the Earth despite the gross similarities between these "twin planets". It is unknown if this apparent divergence was intrinsic, programmed during accretion from distinct nebular reservoirs, or a consequence of either measured or catastrophic processes during planetary evolution. Even if the atmosphere of Venus is a more "recent" development, its relationship to the resurfacing of the planet's enigmatic surface is not well understood. Resolving such uncertainties directly addresses the hypothesis of a more clement, possibly water-rich era in Venus' past as well as whether Earth could become more Venus-like in the future.

  10. Overview of the conceptual design of the future VENUS beamline at the Spallation Neutron Source

    Energy Technology Data Exchange (ETDEWEB)

    Bilheux, Hassina Z [ORNL; Herwig, Kenneth W [ORNL; Keener, Wylie S [ORNL; Davis, Larry E [ORNL


    VENUS will be a world-class neutron-imaging instrument that will uniquely utilize the Spallation Neutron Source (SNS) time-of-flight (TOF) capabilities to measure and characterize objects across several length scales (mm to m). When completed, VENUS will provide academia, industry and government laboratories with the opportunity to advance scientific research in areas such as energy, materials, additive manufacturing, geosciences, transportation, engineering, plant physiology, biology, etc. It is anticipated that a good portion of the VENUS user community will have a strong engineering/industrial research focus. Installed at Beamline 10 (BL10), VENUS will be a 25-m neutron imaging facility with the capability to fully illuminate (i.e., umbra illumination) a 20 cm x 20 cm detector area. The design allows for a 28 cm x 28 cm field of view when using the penumbra to 80% of the full illumination flux. A sample position at 20 m will be implemented for magnification measurements. The optical components are comprised of a series of selected apertures, T0 and bandwidth choppers, beam scrapers, a fast shutter to limit sample activation, and flight tubes filled with Helium. Techniques such as energy selective, Bragg edge and epithermal imaging will be available at VENUS

  11. Prolonged silicon carbide integrated circuit operation in Venus surface atmospheric conditions

    Directory of Open Access Journals (Sweden)

    Philip G. Neudeck


    Full Text Available The prolonged operation of semiconductor integrated circuits (ICs needed for long-duration exploration of the surface of Venus has proven insurmountably challenging to date due to the ∼ 460 °C, ∼ 9.4 MPa caustic environment. Past and planned Venus landers have been limited to a few hours of surface operation, even when IC electronics needed for basic lander operation are protected with heavily cumbersome pressure vessels and cooling measures. Here we demonstrate vastly longer (weeks electrical operation of two silicon carbide (4H-SiC junction field effect transistor (JFET ring oscillator ICs tested with chips directly exposed (no cooling and no protective chip packaging to a high-fidelity physical and chemical reproduction of Venus’ surface atmosphere. This represents more than 100-fold extension of demonstrated Venus environment electronics durability. With further technology maturation, such SiC IC electronics could drastically improve Venus lander designs and mission concepts, fundamentally enabling long-duration enhanced missions to the surface of Venus.

  12. Commissioning of the superconducting ECR ion source VENUS at 18 GHz

    International Nuclear Information System (INIS)

    Leitner, Daniela; Abbott, Steven R.; Dwinell, Roger D.; Leitner, Matthaeus; Taylor, Clyde E.; Lyneis, Claude M.


    During the last year, the VENUS ECR ion source was commissioned at 18 GHz and preparations for 28 GHz operation are now underway. During the commissioning phase with 18 GHz, tests with various gases and metals have been performed with up to 2000 W RF power. The ion source performance is very promising [1,2]. VENUS (Versatile ECR ion source for Nuclear Science) is a next generation superconducting ECR ion source, designed to produce high current, high charge state ions for the 88-Inch Cyclotron at the Lawrence Berkeley National Laboratory. VENUS also serves as the prototype ion source for the RIA (Rare Isotope Accelerator) front end. The goal of the VENUS ECR ion source project as the RIA R and D injector is the production of 240e(micro)A of U 30+ , a high current medium charge state beam. On the other hand, as an injector ion source for the 88-Inch Cyclotron the design objective is the production of 5e(micro)A of U 48+ , a low current, very high charge state beam. To meet these ambitious goals, VENUS has been designed for optimum operation at 28 GHz. This frequency choice has several design consequences. To achieve the required magnetic confinement, superconducting magnets have to be used. The size of the superconducting magnet structure implies a relatively large plasma volume. Consequently, high power microwave coupling becomes necessary to achieve sufficient plasma heating power densities. The 28 GHz power supply has been delivered in April 2004

  13. Transgene and immune gene expression following intramuscular injection of Atlantic salmon (Salmo salar L.) with DNA-releasing PLGA nano- and microparticles. (United States)

    Hølvold, Linn Benjaminsen; Fredriksen, Børge N; Bøgwald, Jarl; Dalmo, Roy A


    The use of poly-(D,L-lactic-co-glycolic) acid (PLGA) particles as carriers for DNA delivery has received considerable attention in mammalian studies. DNA vaccination of fish has been shown to elicit durable transgene expression, but no reports exist on intramuscular administration of PLGA-encapsulated plasmid DNA (pDNA). We injected Atlantic salmon (Salmo salar L.) intramuscularly with a plasmid vector containing a luciferase (Photinus pyralis) reporter gene as a) naked pDNA, b) encapsulated into PLGA nano- (~320 nm) (NP) or microparticles (~4 μm) (MP), c) in an oil-based formulation, or with empty particles of both sizes. The ability of the different pDNA-treatments to induce transgene expression was analyzed through a 70-day experimental period. Anatomical distribution patterns and depot effects were determined by tracking isotope labeled pDNA. Muscle, head kidney and spleen from all treatment groups were analyzed for proinflammatory cytokines (TNF-α, IL-1β), antiviral genes (IFN-α, Mx) and cytotoxic T-cell markers (CD8, Eomes) at mRNA transcription levels at days 1, 2, 4 and 7. Histopathological examinations were performed on injection site samples from days 2, 7 and 30. Injection of either naked pDNA or the oil-formulation was superior to particle treatments for inducing transgene expression at early time-points. Empty particles of both sizes were able to induce proinflammatory immune responses as well as degenerative and inflammatory pathology at the injection site. Microparticles demonstrated injection site depots and an inflammatory pathology comparable to the oil-based formulation. In comparison, the distribution of NP-encapsulated pDNA resembled that of naked pDNA, although encapsulation into NPs significantly elevated the expression of antiviral genes in all tissues. Together the results indicate that while naked pDNA is most efficient for inducing transgene expression, the encapsulation of pDNA into NPs up-regulates antiviral responses that could be

  14. Venus 2004: east and west elongations and solar transit (United States)

    McKim, R. J.; Blaxall, K.; Heath, A.


    The year 2004 was exceptional in producing the first solar transit of Venus since the late Victorian era. The bright aureole and atmospheric ring were re-observed, and the entire phenomenon was witnessed for the first time ever in hydrogen alpha light. Although routine observations throughout 2004 were unexceptional, patterns of visibility of bright and dark markings, cusp extensions and cusp-caps were recorded. No correlation was found between the latitude of the sub-Earth point and the visibility of either cusp-cap, with the S. cap predominating for most of the year. It was possible to accurately follow individual ultraviolet dark markings over many consecutive rotations, extending from the E. to W. elongations, and thereby to make a current measurement of the synodic atmospheric rotation period for the near-equatorial features: 3.996 ± 0.001 days. The true Ashen Light was reported visually on only a few occasions, but these correspond closely to times when infrared emission from the surface of the dark side was recorded in 1-micron waveband images. Some of the stable dark side albedo features were also visible upon the 1-micron images, and have been tentatively identified with known surface features. Infrared imaging at the same waveband showed little detail on the sunlit disk, but a few bright spots were sufficiently well observed to suggest a synodic rotation period close to 5.0 days, not atypical for the lower cloud decks.

  15. Geologic map of the Lada Terra quadrangle (V-56), Venus (United States)

    Kumar, P. Senthil; Head, James W.


    This publication provides a geological map of Lada Terra quadrangle (V–56), a portion of the southern hemisphere of Venus that extends from lat 50° S. to 70° S. and from long 0° E. to 60° E. V–56 is bordered by Kaiwan Fluctus (V–44) and Agnesi (V–45) quadrangles in the north and by Mylitta Fluctus (V–61), Fredegonde (V–57), and Hurston (V–62) quadrangles in the west, east, and south, respectively. The geological map of V–56 quadrangle reveals evidence for tectonic, volcanic, and impact processes in Lada Terra in the form of tesserae, regional extensional belts, coronae, and volcanic plains. In addition, the map also shows relative age relations such as overlapping or cross-cutting relations between the mapped geologic units. The geology observed within this quadrangle addresses (1) how coronae evolved in association with regional extensional belts and (2) how tesserae, regional plains, and impact craters, which are also significant geological units observed in Lada Terra quadrangle, were formed.

  16. The Transit of Venus: an Opportunity to Promote Astronomy (United States)

    Ros, R. M.

    The transit of Venus was an excellent opportunity to promote Astronomy to everybody. In particular this occasion was used to encourage interest in Astronomy in schools. In our society, which has a good quality of life, interest in science has decreased. Every year the number of students interested in studying science degrees at university is smaller than in previous years. Our new generations do not seem to be motivated to study in the field of science. Probably this situation is a consequence of the lack of understanding of the true meaning of science. Of course, it is not possible that a student would decide to study a topic that they do not know about. In the media science appears less than sports, cinema, or business! In consequence, the general public is more concerned about items other than science. On June 8th we took advantage of an opportunity to introduce science and Astronomy into the lives of everybody, but especially in schools. This paper will show two projects related to the transit in schools: ”Pilla el Tránsito de Venus” and ”VT-2004” and a short appendix to another project for schools ”ALMA-ITP”

  17. Structure and dynamics of the ionosphere. [Venus atmosphere (United States)

    Nagy, A. F.; Brace, L. H.


    The structure of the Venus ionosphere and the major processes occurring within it are summarized. The daytime ionosphere is created by solar EUV radiation incident on the thermosphere; it is in photochemical equilibrium near its peak at about 142 km, where O2(+) is the major ion, and near diffusive equilibrium in its upper regions, where the major ion is O(+). The day-to-night plasma pressure gradient across the terminator drives a nightward ion flow which, together with electron precipitation, contributes to the formation of the nighttime ionosphere. Large-scale radial holes or plasma depletions extending downwards to nearly the ionization peak in the antisolar region are also observed which are associated with regions of strong radial magnetic fields. The ionopause is a highly dynamic and complex surface, extending from an average altitude of 290 km at the subsolar point to about 1000 km at the terminator and from 200 to over 3000 km on the nightside. A variety of solar wind interaction products are observed in the mantle, a transition region between the ionospheric plasma and the flowing shocked solar wind.

  18. Outcrops of plastic material on the surface of Venus (United States)

    Ksanfomality, L. V.


    The archive data of the television experiment performed by the Venera-14 spacecraft on the surface of the planet Venus in March, 1982, were reprocessed, which significantly improved the image definition quality. An unusual geologic object located relatively near the camera was found, which allowed its details to be analyzed. The object is a low long bank in shape; it is formed by a relatively thin, jagged, almost vertical stratum. The bank contours the oval formation 1.5-2 m across that stands out against the layered surface. The location of the bank suggests that its material is extruded from under the layered plates surrounding the oval formation. A segment of the bank resembling a falling wave is inclined and partly covers the surface by forming the beddings. The object is likely formed by the rocks that remain semisoftened (plastic), when they appear on the surface at the temperature characteristic for the Venusian surface (about 740 K). It is suggested that, from the data on the physical and chemical conditions and the composition of the Venusian surface, the nature of the observed plastic medium can be hypothesized, and it can be even modeled under laboratory conditions.

  19. Volcanic rises on Venus: Geology, formation, and sequence of evolution (United States)

    Senske, D. A.; Stofan, E. R.; Bindschadler, D. L.; Smrekar, S. E.


    Large centers of volcanism on Venus are concentrated primarily in the equatorial region of the planet and are associated with regional topographic rises. Analysis of both radar images and geophysical data suggest that these uplands are sites of mantle upwelling. Magellan radar imaging provides a globally contiguous data set from which the geology of these regions is evaluated and compared. In addition, high resolution gravity data currently being collected provide a basis to assess the relationship between these uplands and processes in the planet's interior. Studies of the geology of the three largest volcanic highlands (Beta Regio, Atla Regio, Western Eistla Regio) show them to be distinct, having a range of volcanic and tectonic characteristics. In addition to these large areas, a number of smaller uplands are identified and are being analyzed (Bell Regio, Imdr Regio, Dione Regio (Ushas, Innini, and Hathor Montes), and Themis Regio). To understand better the mechanisms by which these volcanic rises form and evolve, we assess their geologic and geophysical characteristics.

  20. The Support of Long Wavelength Loads on Venus (United States)

    Benerdt, W. B.; Saunders, R. S.


    One of the great surprises of the Pioneer Venus mission was the high degree of correlation between topography and gravity found at all wavelengths. This implies a close relationship between topography and lateral subsurface density anomalies, such as those due to passive or dynamic compensation. Sleep-Phillips type compensation model with a variable crustal thickness and a variable upper mantle density was developed. The thin shell theory was used to investigate three end member cases: (1) loading by topographic construction, resulting in a downward deflection of the surface (no mantle support); (2) completely compensated support of a constructional load (no surface deflection); and (3) topography due entirely to upward deflection of the surface supported by a low density upper mantle (no surface load). In general, the models imply relatively thick crust and dense upper mantle for Ishtar Terra and Ovda Regio (western Aphrodite), thinned crust and buoyant upper mantle for Tethus Regio and regions near Sappho and Alpha Regio, and a nearly uniform crust with a buoyant upper mantle for Beta Regio and Atla Regio (eastern Aphrodite).

  1. Large Topographic Rises on Venus: Implications for Mantle Upwelling (United States)

    Stofan, Ellen R.; Smrekar, Suzanne E.; Bindschandler, Duane L.; Senske, David A.


    Topographic rises on Venus have been identified that are interpreted to be the surface manifestation of mantle upwellings. These features are classified into groups based on their dominant morphology. Atla and Beta Regiones are classified as rift-dominated, Dione, western Eistla, Bell, and Imdr Regiones as volcano-dominated, and Themis, eastern Eistla, and central Eistla Regiones as corona-dominated. At several topographic rises, geologic indicators were identified that may provide evidence of uplifted topography (e.g., volcanic flow features trending upslope). We assessed the minimum contribution of volcanic construction to the topography of each rise, which in general represents less than 5% of the volume of the rise, similar to the volumes of edifices at terrestrial hotspot swells. The total melt volume at each rise is approximated to be 10(exp 4) - 10(exp 6) cu km. The variations in morphology, topography, and gravity signatures at topographic rises are not interpreted to indicate variations in stage of evolution of a mantle upwelling. Instead, the morphologic variations between the three classes of topographic rises are interpreted to indicate the varying influences of lithospheric structure, plume characteristics, and regional tectonic environment. Within each class, variations in topography, gravity, and amount of volcanism may be indicative of differing stages of evolution. The similarity between swell and volcanic volumes for terrestrial and Venusian hotspots implies comparable time-integrated plume strengths for individual upwellings on the two planets.

  2. Chinese records of the 1874 transit of Venus (United States)

    Lu, Lingfeng; Li, Huifang


    Before the advent of radar, transits of Venus were very important for measuring the distance between the Earth and the Sun. A transit occurred in 1874, and was visible from China, other parts of east and southeast Asia and from India, Australia and New Zealand and certain islands in the Indian and Pacific Oceans. As a result, many astronomers from Western countries came to China to observe it. According to traditional Chinese astrology, the Sun represented the Emperor, and if the Sun was invaded by other astronomical bodies it meant that the Emperor and the country faced some ominous disaster. In the late nineteenth century, Western astronomical knowledge was widely translated into Chinese and spread among Chinese intellectuals, so the 1874 transit supposedly was easily understood by Chinese intellectuals. Before the transit took place, various Chinese publications introduced this kind of celestial event as science news, but at the same time other influential newspapers and journals discussed the astrological connection between the transit and the fortunes of the nation. In this paper we review these interesting Chinese records and discuss the different attitudes towards the transit exhibited by Chinese intellectuals and officials, during a period when Western learning was being widely disseminated throughout China.

  3. Bilateral topographic symmetry patterns across Aphrodite Terra, Venus

    International Nuclear Information System (INIS)

    Crumpler, L.S.; Head, J.W.


    Western Aphrodite Terra, Venus, is characterized by a series of parallel linear structural discontinuities 2000--4000 km in length and 100--200 km wide, which strike at high angles to the general topographic trend of the Aphrodite Terra highlands. The broad chracteristics of the cross-strike discontinuities (CSDs) are similar to both strike-slip fault zones and terrestrial oceanic fracture zones. In an effort to distinguish between these two hypotheses, topographic profiles were taken across Aphrodite Terra to test for bilateral symmetry of the type associated with thermal boundary layer topography at divergent plate boundaries on Earth. In addition to a broad bilateral symmetry at a range of angles across Aphrodite Terra, detailed bilateral symmetry is observed within domains between linear discontinuities in directions generally parallel to the strike of the discontinuities. In addition, within a domain the centers of symmetry of several profiles define a linear rise crest that is oriented normal to the bounding CSDs and terminates against them

  4. Geologic map of the Themis Regio quadrangle (V-53), Venus (United States)

    Stofan, Ellen R.; Brian, Antony W.


    The Themis Regio quadrangle (V-53), Venus, has been geologically mapped at 1:5,000,000 scale as part of the NASA Planetary Geologic Mapping Program. The quadrangle extends from lat 25° to 50° S. and from long 270° to 300° E. and encompasses the Themis Regio highland, the surrounding plains, and the southernmost extension of Parga Chasmata. Themis Regio is a broad regional topographic high with a diameter of about 2,000 km and a height of about 0.5 km that has been interpreted previously as a hotspot underlain by a mantle plume. The Themis rise is dominated by coronae and lies at the terminus of the Parga Chasmata corona chain. Themis Regio is the only one of the three corona-dominated rises that contains significant extensional deformation. Fractures and grabens are much less common than along the rest of Parga Chasmata and are embayed by corona-related flows in places. Rift and corona formation has overlapped in time at Themis Regio.

  5. Cloud motions on Venus - Global structure and organization (United States)

    Limaye, S. S.; Suomi, V. E.


    Results on cloud motions on Venus obtained over a period of 3.5 days from Mariner 10 television images are presented. The implied atmosphere flow is almost zonal everywhere on the visible disk, and is in the same retrograde sense as the solid planet. Objective analysis of motions suggests the presence of jet cores (-130 m/s) and organized atmospheric waves. The longitudinal mean meridional profile of the zonal component of motion of the ultraviolet features shows presence of a midlatitude jet stream (-110 m/s). The mean zonal component is -97 m/s at the equator. The mean meridional motion at most latitudes is directed toward the pole in either hemisphere and is at least an order of magnitude smaller so that the flow is nearly zonal. A tentative conclusion from the limited coverage available from Mariner 10 is that at the level of ultraviolet features mean meridional circulation is the dominant mode of poleward angular momentum transfer as opposed to the eddy circulation.

  6. Variations in plasma wave intensity with distance along the electron foreshock boundary at Venus (United States)

    Crawford, G. K.; Strangeway, R. J.; Russell, C. T.


    Plasma waves are observed in the solar wind upstream of the Venus bow shock by the Pioneer Venus Orbiter. These wave signatures occur during periods when the interplanetary magnetic field through the spacecraft position intersects the bow shock, thereby placing the spacecraft in the foreshock region. Wave intensity is analyzed as a function of distance along the electron foreshock boundary. It is found that the peak wave intensity may increase along the foreshock boundary from the tangent point to a maximum value at several Venus radii, then decrease in intensity with subsequent increase in distance. These observations could be associated with the instability process: the instability of the distribution function increasing with distance from the tangent point to saturation at the peak. Thermalization of the beam for distances beyond this point could reduce the distribution function instability resulting in weaker wave signatures.

  7. Calculation of the flux density of gamma rays above the surface of Venus and the Earth

    International Nuclear Information System (INIS)

    Surkov, Yu.A.; Manvelyan, O.S.


    In this article the authors present the results of calculating the flux density of unscattered gamma rays as a function of height above the surfaces of Venus and the Earth. At each height they calculate the areas which will collect a certain fraction of the gamma rays. The authors calculate the spectra of scattered gamma rays, as well as their integrated fluxes at various heights above the surface of Venus. They consider how the atmosphere will affect the recording of gamma rays. Their results enable them to evaluate the optimal conditions for measuring the gamma-ray fields above the surfaces of Venus and the Earth and to determine the area of the planet which can be investigated in this way. These results are also necessary if they are to determine the elemental composition of the rock from the characteristic recorded spectrum of gamma radiation

  8. Applicability of ultralow-frequency global resonances for investigating lightning activity on Venus

    International Nuclear Information System (INIS)

    Nikolaenko, A.P.; Rabinovich, L.M.


    The application to experiments on Venus of methods of investigating global lightning activity that are used on earth in the ultralow-frequency range is discussed. Calculations of the electromagnetic fields in the range from a few Hertz to tens of Hertz are carried out in the framework of the model of the lower ionosphere of Venus, which generalizes the information about the planet's atmosphere which is presently available. The calculations showed that observations of global resonances on Venus must, as on the earth, allow one to obtain data about the global distribution of lightning in space and time, and to make the values of the parameters of the lower ionosphere model more precise

  9. The effect of recent Venus transit on Earth’s atmosphere

    Directory of Open Access Journals (Sweden)

    H. P. Sardar


    Full Text Available Some experiments on June 8, 2004, the day of transit of Venus across the Sun, were undertaken at Kolkata (latitude: 22°34lN to observe the effect, if any, of transit of Venus on FWF, ELF and VLF amplitudes. The result shows a good correlation between their temporal variations during the transit. The observation was unbelievable as the Venus subtends only 1/32th of the cone subtended by Sun on Earth. This anomaly may be explained on the assumption that the height of Venusian atmosphere with high content of CO2, and nitrogen which absorbs electromagnetic and corpuscular radiations from Sun, depleting the solar radiation reaching the Earth to a considerable extent. As a result, relevant parameters of Earth’s atmosphere are modulated and here we show how these changes are reflected in identical behaviour of fair weather field and ELF and VLF spectra.

  10. Estimation of the rate of volcanism on Venus from reaction rate measurements (United States)

    Fegley, Bruce, Jr.; Prinn, Ronald G.


    Laboratory rate data for the reaction between SO2 and calcite to form anhydrite are presented. If this reaction rate represents the SO2 reaction rate on Venus, then all SO2 in the Venusian atmosphere will disappear in 1.9 Myr unless volcanism replenishes the lost SO2. The required volcanism rate, which depends on the sulfur content of the erupted material, is in the range 0.4-11 cu km of magma erupted per year. The Venus surface composition at the Venera 13, 14, and Vega 2 landing sites implies a volcanism rate of about 1 cu km/yr. This geochemically estimated rate can be used to determine if either (or neither) of two discordant geophysically estimated rates is correct. It also suggests that Venus may be less volcanically active than the earth.

  11. Propagation of electromagnetic waves parallel to the magnetic field in the nightside Venus ionosphere (United States)

    Huba, J. D.; Rowland, H. L.


    The propagation of electromagnetic waves parallel to the magnetic field in the nightside Venus ionosphere is presented in a theoretical and numerical analysis. The model assumes a source of electromagnetic radiation in the Venus atmosphere, such as that produced by lightning. Specifically addressed is wave propagation in the altitude range z = 130-160 km at the four frequencies detectable by the Pioneer Venus Orbiter Electric Field Detector: 100 Hz, 730 Hz, 5.4 kHz, and 30 kHz. Parameterizations of the wave intensities, peak electron density, and Poynting flux as a function of magnetic field are presented. The waves are found to propagate most easily in conditions of low electron density and high magnetic field. The results of the model are consistent with observational data.

  12. Digital amateur observations of Venus at 0.9μm (United States)

    Kardasis, E.


    Venus atmosphere is extremely dynamic, though it is very difficult to observe any features on it in the visible and even in the near-IR range. Digital observations with planetary cameras in recent years routinely produce high-quality images, especially in the near-infrared (0.7-1μm), since IR wavelengths are less influenced by Earth's atmosphere and Venus's atmosphere is partially transparent in this spectral region. Continuous observations over a few hours may track dark atmospheric features in the dayside and determine their motion. In this work we will present such observations and some dark-feature motion measurements at 0.9μm. Ground-based observations at this wavelength are rare and are complementary to in situ observations by JAXA's Akatsuki orbiter, that studies the atmospheric dynamics of Venus also in this band with the IR1 camera.

  13. Geologic Mapping of the Beta-Atla-Themis (BAT) Region of Venus: A Progress Report (United States)

    Bleamaster, Leslie F., III


    The BAT province is of particular interest with respect to evaluating Venus geologic, tectonic, and volcanic history and provides tests of global paradigms regarding her thermal evolution. The BAT is "ringed" by volcano-tectonic troughs (Parga, Hecate, and Devana Chasmata), has an anomalously high-density of volcanic features with concentrations 2-4 times the global average [1], and is spatially coincident with "young terrain" as illustrated by Average Surface Model Ages [2, 3]. The BAT province is key to understanding Venus current volcanic and tectonic modes, which may provide insight for evaluating Venus historical record. Several quadrangles, two 1:5,000,000 scale - Isabella (V-50) Quadrangle and Devana Chasma (V-29) Quadrangle and two 1:10,000,000 scale - Helen Planitia (I-2477) and Guinevere Planitia (I-2457), are in various stages of production (Figure 1). This abstract will report on their levels of completion as well as highlight some current results and outstanding issues.

  14. Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in  polymorphonuclear cells during latent tuberculous infection

    Directory of Open Access Journals (Sweden)

    Julio E Castañeda-Delgado


    Full Text Available It has been reported that patients with progressive tuberculosis (TB express abundant amounts of the antimicrobial peptides (AMPs cathelicidin (LL-37 and human neutrophil peptide-1 (HNP-1 in circulating cells, whereas latent TB infected donors showed no differences when compared with purified protein derivative (PPD and QuantiFERON®-TB Gold (QFT-healthy individuals. The aim of this study was to determine whether LL-37 and HNP-1 production correlates with higher tuberculin skin test (TST and QFT values in TB household contacts. Twenty-six TB household contact individuals between 26-58 years old TST and QFT positive with at last two years of latent TB infection were recruited. AMPs production by polymorphonuclear cells was determined by flow cytometry and correlation between TST and QFT values was analysed. Our results showed that there is a positive correlation between levels of HNP-1 and LL-37 production with reactivity to TST and/or QFT levels. This preliminary study suggests the potential use of the expression levels of these peptides as biomarkers for progression in latent infected individuals.

  15. An acute injection of corticosterone increases thyrotrophin-releasing hormone expression in the paraventricular nucleus of the hypothalamus but interferes with the rapid hypothalamus pituitary thyroid axis response to cold in male rats. (United States)

    Sotelo-Rivera, I; Jaimes-Hoy, L; Cote-Vélez, A; Espinoza-Ayala, C; Charli, J-L; Joseph-Bravo, P


    The activity of the hypothalamic-pituitary-thyroid (HPT) axis is rapidly adjusted by energy balance alterations. Glucocorticoids can interfere with this activity, although the timing of this interaction is unknown. In vitro studies indicate that, albeit incubation with either glucocorticoid receptor (GR) agonists or protein kinase A (PKA) activators enhances pro-thyrotrophin-releasing hormone (pro-TRH) transcription, co-incubation with both stimuli reduces this enhancement. In the present study, we used primary cultures of hypothalamic cells to test whether the order of these stimuli alters the cross-talk. We observed that a simultaneous or 1-h prior (but not later) activation of GR is necessary to inhibit the stimulatory effect of PKA activation on pro-TRH expression. We tested these in vitro results in the context of a physiological stimulus on the HPT axis in adult male rats. Cold exposure for 1 h enhanced pro-TRH mRNA expression in neurones of the hypophysiotrophic and rostral subdivisions of the paraventricular nucleus (PVN) of the hypothalamus, thyrotrophin (TSH) serum levels and deiodinase 2 (D2) activity in brown adipose tissue (BAT). An i.p. injection of corticosterone stimulated pro-TRH expression in the PVN of rats kept at ambient temperature, more pronouncedly in hypophysiotrophic neurones that no longer responded to cold exposure. In corticosterone-pretreated rats, the cold-induced increase in pro-TRH expression was detected only in the rostral PVN. Corticosterone blunted the increase in serum TSH levels and D2 activity in BAT produced by cold in vehicle-injected animals. Thus, increased serum corticosterone levels rapidly restrain cold stress-induced activation of TRH hypophysiotrophic neurones, which may contribute to changing energy expenditure. Interestingly, TRH neurones of the rostral PVN responded to both corticosterone and cold exposure with an amplified expression of pro-TRH mRNA, suggesting that these neurones integrate stress and temperature

  16. Methane release

    International Nuclear Information System (INIS)

    Seifert, M.


    The Swiss Gas Industry has carried out a systematic, technical estimate of methane release from the complete supply chain from production to consumption for the years 1992/1993. The result of this survey provided a conservative value, amounting to 0.9% of the Swiss domestic output. A continuation of the study taking into account new findings with regard to emission factors and the effect of the climate is now available, which provides a value of 0.8% for the target year of 1996. These results show that the renovation of the network has brought about lower losses in the local gas supplies, particularly for the grey cast iron pipelines. (author)

  17. The Devil in the Dark: A Fully Self-Consistent Seismic Model for Venus (United States)

    Unterborn, C. T.; Schmerr, N. C.; Irving, J. C. E.


    The bulk composition and structure of Venus is unknown despite accounting for 40% of the mass of all the terrestrial planets in our Solar System. As we expand the scope of planetary science to include those planets around other stars, the lack of measurements of basic planetary properties such as moment of inertia, core-size and thermal profile for Venus hinders our ability to compare the potential uniqueness of the Earth and our Solar System to other planetary systems. Here we present fully self-consistent, whole-planet density and seismic velocity profiles calculated using the ExoPlex and BurnMan software packages for various potential Venusian compositions. Using these models, we explore the seismological implications of the different thermal and compositional initial conditions, taking into account phase transitions due to changes in pressure, temperature as well as composition. Using mass-radius constraints, we examine both the centre frequencies of normal mode oscillations and the waveforms and travel times of body waves. Seismic phases which interact with the core, phase transitions in the mantle, and shallower parts of Venus are considered. We also consider the detectability and transmission of these seismic waves from within the dense atmosphere of Venus. Our work provides coupled compositional-seismological reference models for the terrestrial planet in our Solar System of which we know the least. Furthermore, these results point to the potential wealth of fundamental scientific insights into Venus and Earth, as well as exoplanets, which could be gained by including a seismometer on future planetary exploration missions to Venus, the devil in the dark.

  18. New Frontiers Science at Venus from Orbit plus Atmospheric Gas Sampling (United States)

    Smrekar, Suzanne; Dyar, Melinda; Hensley, Scott; Helbert, Joern; VOX Science and Engineering Teams


    Venus remains the most Earth-like body in terms of size, composition, surface age, and insulation. Venus Origins Explorer (VOX) determines how Earth’s twin diverged, and enables breakthroughs in our understanding of rocky planet evolution and habitability. At the time of the Decadal Survey the ability to map mineralogy from orbit (Helbert et al.) and present-day radar techniques to detect active deformation were not fully appreciated. VOX leverages these methods and in-situ noble gases to answer New Frontiers science objectives:1. Atmospheric physics/chemistry: noble gases and isotopes to constrain atmospheric sources, escape processes, and integrated volcanic outgassing; global search for current volcanically outgassed water.2. Past hydrological cycles: global tessera composition to determine the role of volatiles in crustal formation.3. Crustal physics/chemistry: global crustal mineralogy/chemistry, tectonic processes, heat flow, resolve the catastrophic vs. equilibrium resurfacing debate, active geologic processes and possible crustal recycling.4. Crustal weathering: surface-atmosphere weathering reactions from redox state and the chemical equilibrium of the near-surface atmosphere.5. Atmospheric properties/winds: map cloud particle modes and their temporal variations, and track cloud-level winds in the polar vortices.6. Surface-atmosphere interactions: chemical reactions from mineralogy; weathering state between new, recent and older flows; possible volcanically outgassed water.VOX’s Atmosphere Sampling Vehicle (ASV) dips into and samples the well-mixed atmosphere, using Venus Original Constituents Experiment (VOCE) to measure noble gases. VOX’s orbiter carries the Venus Emissivity Mapper (VEM) and the Venus Interferometric Synthetic Aperture Radar (VISAR), and maps the gravity field using Ka-band tracking.VOX is the logical next mission to Venus because it delivers: 1) top priority atmosphere, surface, and interior science; 2) key global data for

  19. VenSAR on EnVision: Taking earth observation radar to Venus (United States)

    Ghail, Richard C.; Hall, David; Mason, Philippa J.; Herrick, Robert R.; Carter, Lynn M.; Williams, Ed


    Venus should be the most Earth-like of all our planetary neighbours: its size, bulk composition and distance from the Sun are very similar to those of Earth. How and why did it all go wrong for Venus? What lessons can be learned about the life story of terrestrial planets in general, in this era of discovery of Earth-like exoplanets? Were the radically different evolutionary paths of Earth and Venus driven solely by distance from the Sun, or do internal dynamics, geological activity, volcanic outgassing and weathering also play an important part? EnVision is a proposed ESA Medium class mission designed to take Earth Observation technology to Venus to measure its current rate of geological activity, determine its geological history, and the origin and maintenance of its hostile atmosphere, to understand how Venus and Earth could have evolved so differently. EnVision will carry three instruments: the Venus Emission Mapper (VEM); the Subsurface Radar Sounder (SRS); and VenSAR, a world-leading European phased array synthetic aperture radar that is the subject of this article. VenSAR will obtain images at a range of spatial resolutions from 30 m regional coverage to 1 m images of selected areas; an improvement of two orders of magnitude on Magellan images; measure topography at 15 m resolution vertical and 60 m spatially from stereo and InSAR data; detect cm-scale change through differential InSAR, to characterise volcanic and tectonic activity, and estimate rates of weathering and surface alteration; and characterise of surface mechanical properties and weathering through multi-polar radar data. These data will be directly comparable with Earth Observation radar data, giving geoscientists unique access to an Earth-sized planet that has evolved on a radically different path to our own, offering new insights on the Earth-sized exoplanets across the galaxy.

  20. Comparative pick-up ion distributions at Mars and Venus: Consequences for atmospheric deposition and escape (United States)

    Curry, Shannon M.; Luhmann, Janet; Ma, Yingjuan; Liemohn, Michael; Dong, Chuanfei; Hara, Takuya


    Without the shielding of a substantial intrinsic dipole magnetic field, the atmospheres of Mars and Venus are particularly susceptible to similar atmospheric ion energization and scavenging processes. However, each planet has different attributes and external conditions controlling its high altitude planetary ion spatial and energy distributions. This paper describes analogous test particle simulations in background MHD fields that allow us to compare the properties and fates, precipitation or escape, of the mainly O+ atmospheric pick-up ions at Mars and Venus. The goal is to illustrate how atmospheric and planetary scales affect the upper atmospheres and space environments of our terrestrial planet neighbors. The results show the expected convection electric field-related hemispheric asymmetries in both precipitation and escape, where the degree of asymmetry at each planet is determined by the planetary scale and local interplanetary field strength. At Venus, the kinetic treatment of O+ reveals a strong nightside source of precipitation while Mars' crustal fields complicate the simple asymmetry in ion precipitation and drive a dayside source of precipitation. The pickup O+ escape pattern at both Venus and Mars exhibits low energy tailward escape, but Mars exhibits a prominent, high energy 'polar plume' feature in the hemisphere of the upward convection electric field while the Venus ion wake shows only a modest poleward concentration. The overall escape is larger at Venus than Mars (2.1 ×1025 and 4.3 ×1024 at solar maximum, respectively), but the efficiency (likelihood) of O+ escaping is 2-3 times higher at Mars. The consequences of these comparisons for pickup ion related atmospheric energy deposition, loss rates, and detection on spacecraft including PVO, VEX, MEX and MAVEN are considered. In particular, both O+ precipitation and escape show electric field controlled asymmetries that grow with energy, while the O+ fluxes and energy spectra at selected spatial

  1. The Effect of Bond Albedo on Venus' Atmospheric and Surface Temperatures (United States)

    Bullock, M. A.; Limaye, S. S.; Grinspoon, D. H.; Way, M.


    In spite of Venus' high planetary albedo, sufficient solar energy reaches the surface to drive a powerful greenhouse effect. The surface temperature is three times higher than it would be without an atmosphere. However, the details of the energy balance within Venus' atmosphere are poorly understood. Half of the solar energy absorbed within the clouds, where most of the solar energy is absorbed, is due to an unknown agent. One of the challenges of modeling Venus' atmosphere has been to account for all the sources of opacity sufficient to generate a globally averaged surface temperature of 735 K, when only 2% of the incoming solar energy is deposited at the surface. The wavelength and spherically integrated albedo, or Bond albedo, has typically been cited as between 0.7 and 0.82 (Colin 1983). Yet, recent photometry of Venus at extended phase angles between 2 and 179° indicate a Bond albedo of 0.90 (Mallama et al., 2006). The authors note an increase in cloud top brightness at phase angles fixed. Figure 1b (right). Venus surface temperature as Bond Albedo changes. Radiative-convective equilibrium models predict the correct globally averaged surface temperature at a=0.81. Calculations here show that a Bond albedo of a=0.9 would yield a surface temperature of 666.4 K, about 70 K too low, unless there is additional thermal absorption within the atmosphere that is not understood. Colin, L.,, Venus, University of Arizona Press, Tucson, 1983, pp 10-26. Mallama, A., et al., 2006. Icarus. 182, 10-22.

  2. Ecotoxicological evaluation of tributyltin toxicity to the equilateral venus clam, Gomphina veneriformis (Bivalvia: Veneridae). (United States)

    Park, Kiyun; Kim, Rosa; Park, Jung Jun; Shin, Hyun Chool; Lee, Jung Sick; Cho, Hyeon Seo; Lee, Yeon Gyu; Kim, Jongkyu; Kwak, Inn-Sil


    Tributyltin (TBT) is the most common pesticide in marine and freshwater environments. To evaluate the potential ecological risk posed by TBT, we measured biological responses such as growth rate, gonad index, sex ratio, the percentage of intersex gonads, filtration rate, and gill abnormalities in the equilateral venus clam (Gomphina veneriformis). Additionally, the biochemical and molecular responses were evaluated in G. veneriformis exposed to various concentrations of TBT. The growth of G. veneriformis was significantly delayed in a dose-dependent manner after exposure to all tested TBT concentrations. After TBT was administered to G. veneriformis, the gonad index decreased and the sex balance was altered. The percentage of intersex gonads also increased significantly in treated females, whereas no intersex gonads were detected in the solvent control group. Additionally, intersex gonads were detected in male G. veneriformis specimens exposed to relatively high TBT concentrations (20 μg L⁻¹). The filtration rate was also reduced in a dose-dependent manner in TBT-exposed G. veneriformis. We also noted abnormal gill morphology in TBT-exposed G. veneriformis. Furthermore, increases in antioxidant enzyme activities were observed in TBT-exposed G. veneriformis clams, regardless of dosage. Vitellogenin gene expression also increased significantly in a dose-dependent manner in G. veneriformis exposed to TBT. These results provide valuable information regarding our understanding of the toxicology of TBT in G. veneriformis. Moreover, the responses of biological and molecular factors could be utilized as information for risk assessments and marine monitoring of TBT toxicity. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

  3. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. (United States)

    Chiba, Shuichi; Numakawa, Tadahiro; Ninomiya, Midori; Richards, Misty C; Wakabayashi, Chisato; Kunugi, Hiroshi


    Stress and the resulting increase in glucocorticoid levels have been implicated in the pathophysiology of depressive disorders. We investigated the effects of chronic restraint stress (CRS: 6 hours × 28 days) on anxiety- and depression-like behaviors in rats and on the possible changes in glucocorticoid receptor (GR) expression as well as brain-derived neurotrophic factor (BDNF)-dependent neural function in the prefrontal cortex (PFC). We observed significant reductions in body weight gain, food intake and sucrose preference from 1 week after the onset of CRS. In the 5th week of CRS, we conducted open-field (OFT), elevated plus-maze (EPM) and forced swim tests (FST). We observed a decrease in the number of entries into open arms during the EPM (anxiety-like behavior) and increased immobility during the FST (depression-like behavior). When the PFC was removed after CRS and subject to western blot analysis, the GR expression reduced compared with control, while the levels of BDNF and its receptors remained unchanged. Basal glutamate concentrations in PFC acute slice which were measured by high performance liquid chromatography were not influenced by CRS. However, BDNF-induced glutamate release was attenuated after CRS. These results suggest that reduced GR expression and altered BDNF function may be involved in chronic stress-induced anxiety--and depression-like behaviors. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression

    Directory of Open Access Journals (Sweden)

    Ming-Horng Tsai


    Full Text Available Ang II has been involved in the pathogenesis of cardiovascular diseases, and matrix metalloproteinase-9 (MMP-9 induced migration of human aortic smooth muscle cells (HASMCs is the most common and basic pathological feature. Carbon monoxide (CO, a byproduct of heme breakdown by heme oxygenase, exerts anti-inflammatory effects in various tissues and organ systems. In the present study, we aimed to investigate the effects and underlying mechanisms of carbon monoxide releasing molecule-2 (CORM-2 on Ang II-induced MMP-9 expression and cell migration of HASMCs. Ang II significantly up-regulated MMP-9 expression and cell migration of HASMCs, which was inhibited by transfection with siRNA of p47phox, Nox2, Nox4, p65, angiotensin II type 1 receptor (AT1R and pretreatment with the inhibitors of NADPH oxidase, ROS, and NF-κB. In addition, Ang II also induced NADPH oxidase/ROS generation and p47phox translocation from the cytosol to the membrane. Moreover, Ang II-induced oxidative stress and MMP-9-dependent cell migration were inhibited by pretreatment with CORM-2. Finally, we observed that Ang II induced IL-6 release in HASMCs via AT1R, but not AT2R, which could further caused MMP-9 secretion and cell migration. Pretreatment with CORM-2 reduced Ang II-induced IL-6 release. In conclusion, CORM-2 inhibits Ang II-induced HASMCs migration through inactivation of suppression of NADPH oxidase/ROS generation, NF-κB inactivation and IL-6/MMP-9 expression. Thus, application of CO, especially CORM-2, is a potential countermeasure to reverse the pathological changes of various cardiovascular diseases. Further effects aimed at identifying novel antioxidant and anti-inflammatory substances protective for heart and blood vessels that targeting CO and establishment of well-designed in vivo models properly evaluating the efficacy of these agents are needed. Keywords: Angiotensin II, Carbon monoxide, Human aortic smooth muscle cell, Inflammation, Matrix metallopeptidase

  5. Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat. (United States)

    Roa, J; Vigo, E; Castellano, J M; Navarro, V M; Fernández-Fernández, R; Casanueva, F F; Dieguez, C; Aguilar, E; Pinilla, L; Tena-Sempere, M


    Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacological characterization of this effect has been mostly conducted in pubertal animals or adult male rodents, whereas similar studies have not been thoroughly conducted in the adult female. In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat. Kisspeptin-10 (1 nmol, intracerebroventricular) was able to elicit robust LH bursts at all phases of the estrous cycle, with maximal responses at estrus; yet, in diestrus LH, responses to kisspeptin were detected at doses as low as 0.1 pmol. In contrast, high doses of kisspeptin only stimulated FSH secretion at diestrus. Removal of ovarian sex steroids did not blunt the ability of kisspeptin to further elicit stimulated LH and FSH secretion, but restoration of maximal responses required replacement with estradiol and progesterone. Finally, despite suppressed basal levels, LH and FSH secretory responses to kisspeptin were preserved in pregnant and lactating females, although the magnitude of LH bursts and the sensitivity to kisspeptin were much higher in pregnant dams. Interestingly, hypothalamic KiSS-1 gene expression significantly increased during pregnancy, whereas GPR54 mRNA levels remained unaltered. In summary, our current data document for the first time the changes in hypothalamic expression of KiSS-1 system and the gonadotropic effects (maximal responses and sensitivity) of kisspeptin in different functional states of the female reproductive axis. The present data may pose interesting implications in light of the

  6. Comparison of the distribution of large magmatic centers on Earth, Venus, and Mars (United States)

    Crumpler, L. S.


    Volcanism is widely distributed over the surfaces of the major terrestrial planets: Venus, Earth, and Mars. Anomalous centers of magmatic activity occur on each planet and are characterized by evidence for unusual concentrations of volcanic centers, long-lived activity, unusual rates of effusion, extreme size of volcanic complexes, compositionally unusual magmatism, and evidence for complex geological development. The purpose of this study is to compare the characteristics and distribution of these magmatic anomalies on Earth, Venus, and Mars in order to assess these characteristics as they may relate to global characteristics and evolution of the terrestrial planets.

  7. Response of Earth and Venus ionospheres to corotating solar wind stream of 3 July 1979

    International Nuclear Information System (INIS)

    Taylor, H.A. Jr.


    Corotating solar wind streams emanating from stable coronal structures provide an unique opportunity to compare the response of planetary ionospheres to the energy conveyed in the streams. For recurrent solar conditions the 'signal' propagating outward along spiral paths in interplanetary space can at times exhibit rather similar content at quite different downstream locations in the ecliptic plane. Using solar wind measurements from plasma detectors on ISEE-3, Pioneer Venus Orbiter (PVO) and Helios-A, as well as in-situ ion composition measurements from Bennett Ion Mass Spectrometers on the Atmosphere Explorer-E and PVO spacecraft, corotating stream interactions are examined at Earth and Venus. (Auth.)

  8. Venus: The case for a wet origin and a runaway greenhouse (United States)

    Kasting, J. F.


    To one interested in atmospheric evolution, the most intriguing aspect of our neighboring planet Venus is its lack of water. Measurements made by Pioneer Venus and by Several Venera spacecraft indicate that the present water abundance in Venus' lower atmosphere is of the order of 20 to 200 ppmv, or 3 x 10( exp -6) to 3 x 10 (exp -5) of the amount of water in Earth's oceans. The exact depletion factor is uncertain, in part because of an unexplained vertical gradient in H2O concentration in the lowest 10 km of the venusian atmosphere, but the general scarcity of water is well established. The interesting question, then, is: Was venus deficient in water when it formed and, if not, where did its water go? The conclusion that Venus was originally wet is consistent with its large endowment of other volatiles and with the enhanced D/H ratio in the present atmosphere. The most likely mechanism by which Venus could have lost its water is by the development of a runaway or moist greenhouse atmosphere followed by photodissociation of water vapor and escape of hydrogen to space. Climate model calculations that neglect cloud albedo feedback predict the existence of two critical transitions in atmospheric behavior at high solar fluxes: (1) at a solar flux of approximately 1.1 times the value at Earth's orbit, S(o), the abundance of stratospheric water vapor increases dramatically, permitting rapid escape of hydrogen to space (termed a moist greenhouse) and (2) at a solar flux of approximately 1.4 S(o), the oceans vaporize entirely, creating a true runaway greenhouse. If cloudiness increases at high surface temperatures, as seems likely, and if the dominant effect of clouds is to cool the planet by reflecting incident solar radiation, the actual solar flux required to create moist or runaway conditions would be higher than the values quoted above. Early in solar system history, solar luminosity was about 25 percent to 30 percent less than today, putting the flux at Venus' orbit

  9. Blaise Cendrars e o Brasil: "Brésil, des hommes sont venus"


    Wimmer, Norma [UNESP


    The paper intitled Blaise Cendrars and Brazil: Brésil, des hommes sont venus discusses the way Cendrars portrays Brazil, and also debates his influence on the artists of the Semana de Arte Moderna (Modern Art Week) in 1922. O texto intitulado Blaise Cendrars e o Brasil: Brésil, des hommes sont venus tece considerações acerca da perspectiva sob a qual Cendrars vê o Brasil, bem como de sua relação com os artistas da Semana de Arte Moderna de 1922.

  10. Modeling Venus-like Worlds Through Time and Implications for the Habitable Zone (United States)

    Way, M.; Del Genio, A. D.; Amundsen, D. S.; Sohl, L. E.; Kiang, N. Y.; Aleinov, I. D.; Kelley, M.


    In recent work [1] we demonstrated that the climatic history of Venus may have allowed for surface liquid water to exist for several billion years using a 3D GCM [2]. Model resolution was 4x5 latitude x longitude, 20 atmospheric layers and a 13 layer fully coupled ocean. Several assumptions were made based on what data we have for early Venus: a.) Used a solar spectrum from 2.9 billion years ago, and 715 million years ago for the incident radiation. b.) Assumed Venus had the same slow modern retrograde rotation throughout the 2.9 to 0.715 Gya history explored, although one simulation at faster rotation rate was shown not to be in the HZ. c.) Used atmospheric constituents similar to modern Earth: 1 bar N2, 400ppmv CO2, 1ppmv CH4. d.) Gave the planet a shallow 310m deep ocean constrained by published D/H ratio observations. e.) Used present day Venus topography and one run with Earth topography.In all cases except the faster rotating one the planet was able to maintain surface liquid water. We have now inserted the SOCRATES [3] radiation scheme into our 3D GCM to more accurately calculate heating fluxes for different atmospheric constituents. Using SOCRATES we have explored a number of other possible early histories for Venus including: f.) An aquaplanet configuration at 2.9Gya with present day rotation period.g.) A Land planet configuration at 2.9Gya with the equivalent of 10m of water in soil and lakes. h.) A synchronously rotating version of a, f, and g (supported by recent work of [4] and older work of [5]) i.) A Venus topography with a 310m ocean, but using present day insolation (1.9 x Earth). j.) Versions of most of the worlds above but with solar insolations >1.9 to explore more Venus-like exoplanetary worlds around G-type stars. In these additional cases the planet still resides in the liquid water habitable zone. Studies such as these should help Astronomers better understand whether exoplanets found in the Venus zone [6] are capable of hosting liquid water

  11. Distribution of ionospheric currents induced by the solar wind interaction with Venus

    International Nuclear Information System (INIS)

    Daniell, R.E. Jr.; Cloutier, P.A.


    The electric currents induced in the atmosphere of a non-magnetic planet such as Venus by the interaction of the solar wind satisfy a generalized Ohm's Law relationship with tensor conductivity. The distribution of these currents within the planetary ionosphere may be calculated by a variational technique which minimizes the Joule heating over the ionospheric volume. In this paper, we present the development of the variational technique, and apply it to a model of the solar wind interaction with Venus. Potential and current distributions are shown, and the use of these distributions in determining convective transport patterns of planetary ions is discussed. (author)

  12. Geological Map of the Fredegonde (V-57) Quadrangle, Venus (United States)

    Ivanov, M. A.; Head, J. W.


    The area of V-57, the Fredegonde quadrangle (50-75degS, 60-120degE, Fig.1), is located within the eastern portion of Lada Terra within the topographic province of midlands (0-2 km above MPR [1,2]). Midlands form the most abundant portion of the surface of Venus and are characterized by diverse sets of units and structures [3-11]. The area of the Fredegonde quadrangle is in contact with the elevated portion of Lada Terra to the W and with the lowland of Aino Planitia to the NE. The transitions of the mid-lands to the lowlands and highlands are, thus, one of the main themes of the geology within the V-57 quadrangle. The character of the transitions and distribution and sequence of units/structures in the midlands are crucially important in understanding the time and modes of formation of this topographic province. The most prominent features in the map area are linear deformational zones consisting of swarms of grooves and graben and large coronae. The zones characterize the central and NW portions of the map area and represent regionally important, broad (up to 100s km wide) ridges that are 100s m high. Relatively small (100s km across, 100s m deep) equidimensional basins occur between the corona-groove-chains in the west and border the central chain from the east. Here we describe units that make up the surface within the V-57 quadrangle and present a summary of our geological map that shows the areal distribution of the major groups of units.

  13. Evidence for volcanism in NW Ishtar Terra, Venus

    International Nuclear Information System (INIS)

    Gaddis, L.; Greeley, R.


    Venera 15/16 radar data for an area in NW Ishtar Terra, Venus, show an area with moderate radar return and a smooth textured surface which embays low lying areas of the surrounding mountainous terrain. Although this unit may be an extension of the lava plains of Lakshmi Planum to the southeast, detailed study suggests a separate volcanic center in NW Ishtar Terra. Lakshmi Planum, on the Ishtar Terra highland, exhibits major volcanic and tectonic features. On the Venera radar image radar brightness is influenced by slope and roughness; radar-facing slopes (east-facing) and rough surfaces (approx. 8 cm average relief) are bright, while west-facing slopes and smooth surfaces are dark. A series of semi-circular features, apparently topographic depressions, do not conform in orientation to major structural trends in this region of NW Ishtar Terra. The large depression in NW Ishtar Terra is similar to the calderas of Colette and Sacajawea Paterae, as all three structures are large irregular depressions. NW Ishtar Terra appears to be the site of a volcanic center with a complex caldera structure, possibly more than one eruptive vent, and associated lobed flows at lower elevations. The morphologic similarity between this volcanic center and those of Colette and Sacajawea suggests that centralized eruptions have been the dominant form of volcanism in Ishtar. The location of this volcanic center at the intersection of two major compressional mountain belts and the large size of the calders (with an inferred larg/deep magma source) support a crustal thickening/melting rather than a hot-spot origin for these magmas

  14. Tidal Venuses: triggering a climate catastrophe via tidal heating. (United States)

    Barnes, Rory; Mullins, Kristina; Goldblatt, Colin; Meadows, Victoria S; Kasting, James F; Heller, René


    Traditionally, stellar radiation has been the only heat source considered capable of determining global climate on long timescales. Here, we show that terrestrial exoplanets orbiting low-mass stars may be tidally heated at high-enough levels to induce a runaway greenhouse for a long-enough duration for all the hydrogen to escape. Without hydrogen, the planet no longer has water and cannot support life. We call these planets "Tidal Venuses" and the phenomenon a "tidal greenhouse." Tidal effects also circularize the orbit, which decreases tidal heating. Hence, some planets may form with large eccentricity, with its accompanying large tidal heating, and lose their water, but eventually settle into nearly circular orbits (i.e., with negligible tidal heating) in the habitable zone (HZ). However, these planets are not habitable, as past tidal heating desiccated them, and hence should not be ranked highly for detailed follow-up observations aimed at detecting biosignatures. We simulated the evolution of hypothetical planetary systems in a quasi-continuous parameter distribution and found that we could constrain the history of the system by statistical arguments. Planets orbiting stars with massesplanet orbiting a 0.3 MSun star at 0.12 AU. We found that it probably did not lose its water via tidal heating, as orbital stability is unlikely for the high eccentricities required for the tidal greenhouse. As the inner edge of the HZ is defined by the onset of a runaway or moist greenhouse powered by radiation, our results represent a fundamental revision to the HZ for noncircular orbits. In the appendices we review (a) the moist and runaway greenhouses, (b) hydrogen escape, (c) stellar mass-radius and mass-luminosity relations, (d) terrestrial planet mass-radius relations, and (e) linear tidal theories.

  15. Venera 15: Water vapour in the middle atmosphere of Venus (United States)

    Ignatiev, N. I.; Moroz, V. I.; Zasova, L. V.; Khatuntsev, I. V.


    In 1983, spectra of Venus in the region of 6-40 μm were measured by means of the Fourier Spectrometer aboard the Venera 15 orbiter. It covered local solar times from 4 a.m. to 10 a.m. and from 4 p.m. to 10 p.m. in the latitude range from -65° up to 87°. The results of an extended processing and analysis of these data are presented. Time and spatial variations of the water vapour were found. Most of the measurements fall in the range of 5-15 ppm, which is close to the early results. The effective altitude of sounding is approximately equal to the altitude where the optical depth τ = 1. Two latitude regions can be distinguished: (A) 20° 60°, which are characterised by different altitudes of the level of τ = 1: 62 and 55 km respectively. Mean mixing ratios near this level in the two regions are almost the same, but the partial pressures and mass densities in region (B) are 2-4 times greater than those in region (A). In region (A) a weak dayside maximum and a nightside minimum were observed. Region (B) is of inhomogeneous structure, and the retrieved mixing ratio has greater uncertainty and may probably change from the detection limit of 1 ppm up to 30 ppm. Although the retrieval of H2O mixing ratio altitude profile from the Venera 15 data appeared to be impossible, indirect indications were found that at least in region (A) the mixing ratio decreases with altitude.

  16. Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors. (United States)

    Accardo, Antonella; Galli, Filippo; Mansi, Rosalba; Del Pozzo, Luigi; Aurilio, Michela; Morisco, Anna; Ringhieri, Paola; Signore, Alberto; Morelli, Giancarlo; Aloj, Luigi


    Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabeled peptide-based ligands toward these receptors for the purpose of in vivo imaging and radionuclide therapy of GRP-R-overexpressing tumors. A number of different peptide sequences, isotopes, and labeling methods have been proposed for this purpose. The aim of this work is to perform a direct side-by-side comparison of different GRP-R binding peptides utilizing a single labeling strategy to identify the most suitable peptide sequence. Solid-phase synthesis of eight derivatives (BN1-8) designed based on literature analysis was carried out. Peptides were coupled to the DOTA chelator through a PEG4 spacer at the N-terminus. Derivatives were characterized for serum stability, binding affinity on PC-3 human prostate cancer cells, biodistribution in tumor-bearing mice, and gamma camera imaging at 1, 6, and 24 h after injection. Serum stability was quite variable among the different compounds with half-lives ranging from 16 to 400 min at 37 °C. All compounds tested showed K d values in the nanomolar range with the exception of BN3 that showed no binding. Biodistribution and imaging studies carried out for compounds BN1, BN4, BN7, and BN8 showed targeting of the GRP-R-positive tumors and the pancreas. The BN8 compound (DOTA-PEG-DPhe-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2) showed high affinity, the longest serum stability, and the highest target-to-background ratios in biodistribution and imaging experiments among the compounds tested. Our results indicate that the NMeGly for Gly substitution and the Sta-Leu substitution at the C-terminus confer high serum stability while maintaining high receptor affinity, resulting in biodistribution properties that outperform those of the other peptides.

  17. Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha

    DEFF Research Database (Denmark)

    Bouchelouche, Kirsten; Andresen, Lars; Alvarez, Susana


    Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle. However, to our knowledge the factors that influence the anatomical relationship between MCs and HDSMCs are unknown. MCP-1, IL-6 and SCF have a critical role in the regulation of MC development,......, signaling and function. We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.......Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle. However, to our knowledge the factors that influence the anatomical relationship between MCs and HDSMCs are unknown. MCP-1, IL-6 and SCF have a critical role in the regulation of MC development...

  18. mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene-related peptide in the rat trigeminovascular system

    DEFF Research Database (Denmark)

    Amrutkar, Dipak V; Ploug, Kenneth B; Hay-Schmidt, Anders


    Triptans, a family of 5-hydroxytryptamine (5-HT) 1B, 1D, and 1F receptor agonists, are used in the acute treatment of migraine attacks. The site of action and subtypes of the 5-HT(1) receptor that mediate the antimigraine effect have still to be identified. This study investigated the mRNA expres......Triptans, a family of 5-hydroxytryptamine (5-HT) 1B, 1D, and 1F receptor agonists, are used in the acute treatment of migraine attacks. The site of action and subtypes of the 5-HT(1) receptor that mediate the antimigraine effect have still to be identified. This study investigated the m......RNA expression of these receptors and the role of 5-HT(1) receptor subtypes in controlling the release of calcitonin gene-related peptide (CGRP) in rat dura mater, trigeminal ganglion (TG), and trigeminal nucleus caudalis (TNC). The mRNA for each receptor subtype was quantified by quantitative real...

  19. Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Carlos Manuel Zapata-Martín del Campo


    Full Text Available Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and some cytokines contribute to the long-term modulation and restructuring of cardiovascular regulation networks and, at the same time, have relevance in situations of comorbid abnormal stress responses. The synthesis, release, and receptor expression of these mediators seem to be under epigenetic control since early stages of life, possibly underlying the comorbidity to coronary artery disease (CAD and stress-related disorders (SRD. The exposure to environmental conditions, such as stress, during critical periods in early life may cause epigenetic programming modifying the development of pathways that lead to stable and long-lasting alterations in the functioning of these mediators during adulthood, determining the risk of or resilience to CAD and SRD. However, in contrast to genetic information, epigenetic marks may be dynamically altered throughout the lifespan. Therefore, epigenetics may be reprogrammed if the individual accepts the challenge to undertake changes in their lifestyle. Alternatively, epigenetics may remain fixed and/or even be inherited in the next generation. In this paper, we analyze some of the common neuroendocrine functions of these mediators in CAD and SRD and summarize the evidence indicating that they are under early programming to put forward the theoretical hypothesis that the comorbidity of these diseases might be epigenetically programmed and modified over the lifespan of the individual.

  20. Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease (United States)

    Zapata-Martín del Campo, Carlos Manuel; Martínez-Rosas, Martín


    Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and some cytokines contribute to the long-term modulation and restructuring of cardiovascular regulation networks and, at the same time, have relevance in situations of comorbid abnormal stress responses. The synthesis, release, and receptor expression of these mediators seem to be under epigenetic control since early stages of life, possibly underlying the comorbidity to coronary artery disease (CAD) and stress-related disorders (SRD). The exposure to environmental conditions, such as stress, during critical periods in early life may cause epigenetic programming modifying the development of pathways that lead to stable and long-lasting alterations in the functioning of these mediators during adulthood, determining the risk of or resilience to CAD and SRD. However, in contrast to genetic information, epigenetic marks may be dynamically altered throughout the lifespan. Therefore, epigenetics may be reprogrammed if the individual accepts the challenge to undertake changes in their lifestyle. Alternatively, epigenetics may remain fixed and/or even be inherited in the next generation. In this paper, we analyze some of the common neuroendocrine functions of these mediators in CAD and SRD and summarize the evidence indicating that they are under early programming to put forward the theoretical hypothesis that the comorbidity of these diseases might be epigenetically programmed and modified over the lifespan of the individual. PMID:29670001

  1. Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease. (United States)

    Zapata-Martín Del Campo, Carlos Manuel; Martínez-Rosas, Martín; Guarner-Lans, Verónica


    Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and some cytokines contribute to the long-term modulation and restructuring of cardiovascular regulation networks and, at the same time, have relevance in situations of comorbid abnormal stress responses. The synthesis, release, and receptor expression of these mediators seem to be under epigenetic control since early stages of life, possibly underlying the comorbidity to coronary artery disease (CAD) and stress-related disorders (SRD). The exposure to environmental conditions, such as stress, during critical periods in early life may cause epigenetic programming modifying the development of pathways that lead to stable and long-lasting alterations in the functioning of these mediators during adulthood, determining the risk of or resilience to CAD and SRD. However, in contrast to genetic information, epigenetic marks may be dynamically altered throughout the lifespan. Therefore, epigenetics may be reprogrammed if the individual accepts the challenge to undertake changes in their lifestyle. Alternatively, epigenetics may remain fixed and/or even be inherited in the next generation. In this paper, we analyze some of the common neuroendocrine functions of these mediators in CAD and SRD and summarize the evidence indicating that they are under early programming to put forward the theoretical hypothesis that the comorbidity of these diseases might be epigenetically programmed and modified over the lifespan of the individual.

  2. Barrier and operational risk analysis of hydrocarbon releases (BORA-Release)

    International Nuclear Information System (INIS)

    Sklet, Snorre; Vinnem, Jan Erik; Aven, Terje


    This paper presents results from a case study carried out on an offshore oil and gas production platform with the purpose to apply and test BORA-Release, a method for barrier and operational risk analysis of hydrocarbon releases. A description of the BORA-Release method is given in Part I of the paper. BORA-Release is applied to express the platform specific hydrocarbon release frequencies for three release scenarios for selected systems and activities on the platform. The case study demonstrated that the BORA-Release method is a useful tool for analysing the effect on the release frequency of safety barriers introduced to prevent hydrocarbon releases, and to study the effect on the barrier performance of platform specific conditions of technical, human, operational, and organisational risk influencing factors (RIFs). BORA-Release may also be used to analyse the effect on the release frequency of risk reducing measures

  3. Purification and Characterization of Hemagglutinating Proteins from Poker-Chip Venus (Meretrix lusoria and Corbicula Clam (Corbicula fluminea

    Directory of Open Access Journals (Sweden)

    Chin-Fu Cheng


    Full Text Available Hemagglutinating proteins (HAPs were purified from Poker-chip Venus (Meretrix lusoria and Corbicula clam (Corbicula fluminea using gel-filtration chromatography on a Sephacryl S-300 column. The molecular weights of the HAPs obtained from Poker-chip Venus and Corbicula clam were 358 kDa and 380 kDa, respectively. Purified HAP from Poker-chip Venus yielded two subunits with molecular weights of 26 kDa and 29 kDa. However, only one HAP subunit was purified from Corbicula clam, and its molecular weight was 32 kDa. The two Poker-chip Venus HAPs possessed hemagglutinating ability (HAA for erythrocytes of some vertebrate animal species, especially tilapia. Moreover, HAA of the HAP purified from Poker-chip Venus was higher than that of the HAP of Corbicula clam. Furthermore, Poker-chip Venus HAPs possessed better HAA at a pH higher than 7.0. When the temperature was at 4°C–10°C or the salinity was less than 0.5‰, the two Poker-chip Venus HAPs possessed better HAA compared with that of Corbicula clam.


    Energy Technology Data Exchange (ETDEWEB)

    S.O. Bader


    The purpose of this design analysis is to specify and document the total and respirable fractions for radioactive materials that are released from an accident event at the Monitored Geologic Repository (MGR) involving commercial spent nuclear fuel (CSNF) in a dry environment. The total and respirable release fractions will be used to support the preclosure licensing basis for the MGR. The total release fraction is defined as the fraction of total CSNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. The radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses. This subset of the total release fraction is referred to as the respirable release fraction. Potential accidents may involve waste forms that are characterized as either bare (unconfined) fuel assemblies or confined fuel assemblies. The confined CSNF assemblies at the MGR are contained in shipping casks, canisters, or disposal containers (waste packages). In contrast to the bare fuel assemblies, the container that confines the fuel assemblies has the potential of providing an additional barrier for diminishing the total release fraction should the fuel rod cladding breach during an accident. However, this analysis will not take credit for this additional bamer and will establish only the total release fractions for bare unconfined CSNF assemblies, which may however be


    International Nuclear Information System (INIS)

    S.O. Bader


    The purpose of this design analysis is to specify and document the total and respirable fractions for radioactive materials that are released from an accident event at the Monitored Geologic Repository (MGR) involving commercial spent nuclear fuel (CSNF) in a dry environment. The total and respirable release fractions will be used to support the preclosure licensing basis for the MGR. The total release fraction is defined as the fraction of total CSNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. The radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses. This subset of the total release fraction is referred to as the respirable release fraction. Potential accidents may involve waste forms that are characterized as either bare (unconfined) fuel assemblies or confined fuel assemblies. The confined CSNF assemblies at the MGR are contained in shipping casks, canisters, or disposal containers (waste packages). In contrast to the bare fuel assemblies, the container that confines the fuel assemblies has the potential of providing an additional barrier for diminishing the total release fraction should the fuel rod cladding breach during an accident. However, this analysis will not take credit for this additional bamer and will establish only the total release fractions for bare unconfined CSNF assemblies, which may however be

  6. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles

    International Nuclear Information System (INIS)

    Lin, C.-L.; Leu, Steve; Lu, M.-C.; Ouyang Pin


    Pre-mRNA splicing takes place within a dynamic ribonucleoprotein particle called the spliceosome and occurs in an ordered pathway. Although it is known that spliceosome consists of five small nuclear RNAs and at least 50 proteins, little is known about how the interaction among the proteins changes during splicing. Here we identify that SR-cyp, a Moca family of nuclear cyclophilin, interacts and colocalizes with nuclear pinin (pnn), a SR-related protein involving in pre-mRNA splicing. Nuclear pnn interacts with SR-cyp via its C-terminal RS domain. Upon SR-cyp over-expression, however, the subnuclear distribution of nuclear pnn is altered, resulting in its redistribution from nuclear speckles to a diffuse nucleoplasmic form. The diffuse subnuclear distribution of nuclear pnn is not due to epitope masking, accelerated protein turnover or post-translational modification. Furthermore, we find that SR-cyp regulates the subnuclear distribution of other SR family proteins, including SC35 and SRm300, in a similar manner as it does on nuclear pnn. This result is significant because it suggests that SR-cyp plays a general role in modulating the distribution pattern of SR-like and SR proteins, similar to that of Clk (cdc2-like kinase)/STY on SR family splicing factors. SR-cyp might direct its effect via either alteration of protein folding/conformation or of protein-protein interaction and thus may add another control level of regulation of SR family proteins and modification of their functions

  7. Constraints on the gamma-ray burst luminosity function from Pioneer Venus Orbiter and BATSE observations

    NARCIS (Netherlands)

    Ulmer, A.; Wijers, R.A.M.J.; Fenimore, E.E.


    We examine the width of the gamma ray burst luminosity function through the distribution of Gamma Ray Burst (GRB) peak fluxes as detected by the Pioneer Venus Orbiter (PVO) and the Burst and Transient Source Experiment (BATSE). The strength of the analysis is greatly enhanced by using a merged

  8. Radioisotope Stirling Engine Powered Airship for Low Altitude Operation on Venus (United States)

    Colozza, Anthony J.


    The feasibility of a Stirling engine powered airship for the near surface exploration of Venus was evaluated. The heat source for the Stirling engine was limited to 10 general purpose heat source (GPHS) blocks. The baseline airship utilized hydrogen as the lifting gas and the electronics and payload were enclosed in a cooled insulated pressure vessel to maintain the internal temperature at 320 K and 1 Bar pressure. The propulsion system consisted of an electric motor driving a propeller. An analysis was set up to size the airship that could operate near the Venus surface based on the available thermal power. The atmospheric conditions on Venus were modeled and used in the analysis. The analysis was an iterative process between sizing the airship to carry a specified payload and the power required to operate the electronics, payload and cooling system as well as provide power to the propulsion system to overcome the drag on the airship. A baseline configuration was determined that could meet the power requirements and operate near the Venus surface. From this baseline design additional trades were made to see how other factors affected the design such as the internal temperature of the payload chamber and the flight altitude. In addition other lifting methods were evaluated such as an evacuated chamber, heated atmospheric gas and augmented heated lifting gas. However none of these methods proved viable.

  9. CUVE - Cubesat UV Experiment: Unveil Venus' UV Absorber with Cubesat UV Mapping Spectrometer (United States)

    Cottini, V.; Aslam, S.; D'Aversa, E.; Glaze, L.; Gorius, N.; Hewagama, T.; Ignatiev, N.; Piccioni, G.


    Our Venus mission concept Cubesat UV Experiment (CUVE) is one of ten proposals selected for funding by the NASA PSDS3 Program - Planetary Science Deep Space SmallSat Studies. CUVE concept is to insert a CubeSat spacecraft into a Venusian orbit and perform remote sensing of the UV spectral region using a high spectral resolution point spectrometer to resolve UV molecular bands, observe nightglow, and characterize the unidentified main UV absorber. The UV spectrometer is complemented by an imaging UV camera with multiple bands in the UV absorber main band range for contextual imaging. CUVE Science Objectives are: the nature of the "Unknown" UV-absorber; the abundances and distributions of SO2 and SO at and above Venus's cloud tops and their correlation with the UV absorber; the atmospheric dynamics at the cloud tops, structure of upper clouds and wind measurements from cloud-tracking; the nightglow emissions: NO, CO, O2. This mission will therefore be an excellent platform to study Venus' cloud top atmospheric properties where the UV absorption drives the planet's energy balance. CUVE would complement past, current and future Venus missions with conventional spacecraft, and address critical science questions cost effectively.

  10. Did Ibn Sina Observe the Transit of Venus of 1032 CE? (United States)

    Kapoor, R. C.


    The Persian polymath Abu Ali ibn Sina (980--1037 CE), known to early Western sources as Avicenna, records that ``I say that I saw Venus as a spot on the surface of the sun''. This statement has been quoted, for example, by Nasir al Din al Tusi (1201--1274 CE). A Transit of Venus indeed took place during ibn Sina's life time, that is on 24 May 1032 CE. Did ibn Sina see this Transit or did he merely see a sunspot? The question was addressed by Bernard R. Goldstein in 1969 who concluded that ``this Transit may not have been visible where he lived''. Goldstein based his conclusion on the input provided by Brian G Marsden who in turn used mathematical tables prepared by J. Meeus in 1958. I have begun re-examination of the question by employing Fred Espenak's Transit predictions. Preliminary work shows that ibn Sina could indeed have obtained a glimpse of the Transit of Venus just before sunset from places like Isfahan or Hamadan. In other words, when ibn Sina said he saw Venus on the surface of the Sun, he probably meant it.

  11. Kepler-1649b: An Exo-Venus in the Solar Neighborhood

    Energy Technology Data Exchange (ETDEWEB)

    Angelo, Isabel; Rowe, Jason F.; Huber, Daniel [SETI Institute, Mountain View, CA 94043 (United States); Howell, Steve B.; Quintana, Elisa V.; Burningham, Ben; Barclay, Thomas [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Still, Martin [Bay Area Environmental Research Institute, 625 2nd Street, Suite 209, Petaluma, CA 94952 (United States); Mann, Andrew W. [Department of Astronomy, The University of Texas at Austin, Austin, TX 78712 (United States); Ciardi, David R. [NASA Exoplanet Science Institute/Caltech, Pasadena, CA (United States); Kane, Stephen R., E-mail: [Department of Physics and Astronomy, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132 (United States)


    The Kepler mission has revealed that Earth-sized planets are common, and dozens have been discovered to orbit in or near their host star’s habitable zone. A major focus in astronomy is to determine which of these exoplanets are likely to have Earth-like properties that are amenable to follow-up with both ground- and future space-based surveys, with an ultimate goal of probing their atmospheres to look for signs of life. Venus-like atmospheres will be of particular interest in these surveys. While Earth and Venus evolved to have similar sizes and densities, it remains unclear what factors led to the dramatic divergence of their atmospheres. Studying analogs to both Earth and Venus can thus shed light on the limits of habitability and the potential for life on known exoplanets. Here, we present the discovery and confirmation of Kepler-1649b, an Earth-sized planet orbiting a nearby M5V star that receives incident flux at a level similar to that of Venus. We present our methods for characterizing the star, using a combination of point-spread function photometry, ground-based spectroscopy, and imaging, to confirm the planetary nature of Kepler-1649b. Planets like Kepler-1649b will be prime candidates for atmospheric and habitability studies in the next generation of space missions.

  12. Phyto-oestrogen levels in foods : The design and construction of the VENUS database

    NARCIS (Netherlands)

    Kiely, M.; Faughnan, M.; Wähälä, K.; Brants, H.; Mulligan, A.


    The objective of the Vegetal Estrogens in Nutrition and the Skeleton (VENUS) project was to evaluate existing data on dietary exposure to compounds with oestrogenic and anti-oestrogenic effects present in plant foods as constituents or contaminants, and to identify and disseminate in vitro and in

  13. Sales and procurement : either from Mars or Venus -- or more together

    NARCIS (Netherlands)

    Staal, Anne


    Much has been written on differences and similarities of B2B sales and procurement professionals. Sometimes these two types seem to come from two different planets, but then we hear talk of synergies and the need to cooperate more closely. Let’s first discuss the “Women Are from Venus; Men Are from

  14. Kepler-1649b: An Exo-Venus in the Solar Neighborhood

    International Nuclear Information System (INIS)

    Angelo, Isabel; Rowe, Jason F.; Huber, Daniel; Howell, Steve B.; Quintana, Elisa V.; Burningham, Ben; Barclay, Thomas; Still, Martin; Mann, Andrew W.; Ciardi, David R.; Kane, Stephen R.


    The Kepler mission has revealed that Earth-sized planets are common, and dozens have been discovered to orbit in or near their host star’s habitable zone. A major focus in astronomy is to determine which of these exoplanets are likely to have Earth-like properties that are amenable to follow-up with both ground- and future space-based surveys, with an ultimate goal of probing their atmospheres to look for signs of life. Venus-like atmospheres will be of particular interest in these surveys. While Earth and Venus evolved to have similar sizes and densities, it remains unclear what factors led to the dramatic divergence of their atmospheres. Studying analogs to both Earth and Venus can thus shed light on the limits of habitability and the potential for life on known exoplanets. Here, we present the discovery and confirmation of Kepler-1649b, an Earth-sized planet orbiting a nearby M5V star that receives incident flux at a level similar to that of Venus. We present our methods for characterizing the star, using a combination of point-spread function photometry, ground-based spectroscopy, and imaging, to confirm the planetary nature of Kepler-1649b. Planets like Kepler-1649b will be prime candidates for atmospheric and habitability studies in the next generation of space missions.

  15. Regional mantle upwelling on Venus: The Beta-Atla-Themis anomaly and correlation with global tectonic patterns (United States)

    Crumpler, L. S.; Head, J. W.; Aubele, Jayne C.


    The morphology and global distribution of volcanic centers and their association with other geological characteristics offers significant insight into the global patterns of geology, tectonic style, thermal state, and interior dynamics of Venus. Magellan data permit the detailed geological interpretation necessary to address questions about interior dynamics of Venus particularly as they reflect relatively physical, chemical, and thermal conditions of the interior. This paper focuses on the distribution of anomalous concentrations of volcanic centers on Venus and regional patterns of tectonic deformation as it may relate to the identification of global internal anomalies, including mantle dynamic, petrological, or thermal patterns.

  16. Quantitative analysis of terrain units mapped in the northern quarter of Venus from Venera 15/16 data (United States)

    Schaber, G. G.


    The contacts between 34 geological/geomorphic terrain units in the northern quarter of Venus mapped from Venera 15/16 data were digitized and converted to a Sinusoidal Equal-Area projection. The result was then registered with a merged Pioneer Venus/Venera 15/16 altimetric database, root mean square (rms) slope values, and radar reflectivity values derived from Pioneer Venus. The resulting information includes comparisons among individual terrain units and terrain groups to which they are assigned in regard to percentage of map area covered, elevation, rms slopes, distribution of suspected craters greater than 10 km in diameter.

  17. Remote Raman - laser induced breakdown spectroscopy (LIBS) geochemical investigation under Venus atmospheric conditions

    Energy Technology Data Exchange (ETDEWEB)

    Clegg, Sanuel M [Los Alamos National Laboratory; Barefield, James E [Los Alamos National Laboratory; Humphries, Seth D [Los Alamos National Laboratory; Wiens, Roger C [Los Alamos National Laboratory; Vaniman, D. T. [Los Alamos National Laboratory; Sharma, S. K. [UNIV OF HAWAII; Misra, A. K. [UNIV OF HAWAII; Dyar, M. D. [MT. HOLYOKE COLLEGE; Smrekar, S. E. [JET PROPULSION LAB.


    The extreme Venus surface temperatures ({approx}740 K) and atmospheric pressures ({approx}93 atm) create a challenging environment for surface missions. Scientific investigations capable of Venus geochemical observations must be completed within hours of landing before the lander will be overcome by the harsh atmosphere. A combined remote Raman - LIBS (Laser Induced Breakdown Spectroscopy) instrument is capable of accomplishing the geochemical science goals without the risks associated with collecting samples and bringing them into the lander. Wiens et al. and Sharma et al. demonstrated that both analytical techniques can be integrated into a single instrument capable of planetary missions. The focus of this paper is to explore the capability to probe geologic samples with Raman - LIBS and demonstrate quantitative analysis under Venus surface conditions. Raman and LIBS are highly complementary analytical techniques capable of detecting both the mineralogical and geochemical composition of Venus surface materials. These techniques have the potential to profoundly increase our knowledge of the Venus surface composition, which is currently limited to geochemical data from Soviet Venera and VEGA landers that collectively suggest a surface composition that is primarily tholeiitic basaltic with some potentially more evolved compositions and, in some locations, K-rich trachyandesite. These landers were not equipped to probe the surface mineralogy as can be accomplished with Raman spectroscopy. Based on the observed compositional differences and recognizing the imprecise nature of the existing data, 15 samples were chosen to constitute a Venus-analog suite for this study, including five basalts, two each of andesites, dacites, and sulfates, and single samples of a foidite, trachyandesite, rhyolite, and basaltic trachyandesite under Venus conditions. LIBS data reduction involved generating a partial least squares (PLS) model with a subset of the rock powder standards to

  18. Multi-functional system of radiotherapy and thermal phototherapy for tumors that over-express receptors of the gastrin releasing peptide

    International Nuclear Information System (INIS)

    Jimenez M, N. P.


    purity was 96 ± 2%, no further purification was necessary. In vitro studies showed that after laser irradiation, the presence of AuNP-Tat-Bn caused a significant increase in the temperature of the medium (46.4 grades C vs. 39.5 grades C of that without AuNP) resulting in a significant decrease in PC3 cell viability down to 1.3 %. In the in vivo studies the 177 Lu/ 99m Tc-AuNP-Tat-Bn showed a biological residence time of 80.6 h. The radiation absorbed doses from 177 Lu and 99m Tc to the tumor after normalization to the unit of administered activity were 7.90 ± 0.95 Gy/MBq and 0.07±0.01 Gy/MBq, respectively. Fluorescent images showed that the system was internalized into the nucleus of PC3 cells. The 177 Lu/ 99m Tc-AuNP-Tat-Bn system showed properties suitable for a targeted radionuclide therapy of tumours expressing GRP receptors due to the energy deposition from β-emissions and the Auger and internal conversion electron emissions near the DNA. It has potential application in medical diagnosis and therapeutic treatments due to its unique combination of radioactive, optical and thermo ablative properties, therefore, this study demonstrated that the nano system exhibited properties that are suitable for plasmonic photothermal therapy and targeted radiotherapy in the treatment of prostate cancer. (Author)

  19. Venus - 3D Perspective View of Eastern Edge of Alpha Regio (United States)


    A portion of the eastern edge of Alpha Regio is displayed in this three-dimensional perspective view of the surface of Venus. The viewpoint is located at approximately 30 degrees south latitude, 11.8 degrees east longitude at an elevation of 2.4 kilometers (3.8 miles). The view is to the northeast at the center of an area containing seven circular dome-like hills. The average diameter of the hills is 25 kilometers (15 miles) with maximum heights of 750 meters (2,475 feet). Three of the hills are visible in the center of the image. Fractures on the surrounding plains are both older and younger than the domes. The hills may be the result of viscous or thick eruptions of lava coming from a vent on the relatively level ground, allowing the lava to flow in an even lateral pattern. The concentric and radial fracture patterns on their surfaces suggests that a chilled outer layer formed, then further intrusion in the interior stretched the surface. An alternative interpretation is that domes are the result of shallow intrusions of molten lava, causing the surface to rise. If they are intrusive, then magma withdrawal near the end of the eruptions produced the fractures. The bright margins possibly indicate the presence of rock debris or talus at the slopes of the domes. Resolution of the Magellan data is about 120 meters (400 feet). Magellan's synthetic aperture radar is combined with radar altimetry to develop a three-dimensional map of the surface. A perspective view is then generated from the map. Simulated color and a process called radar-clinometry are used to enhance small-scale structures. The simulated hues are based on color images recorded by the Soviet Venera 13 and 14 spacecraft. The image was produced by the JPL Multimission Image Processing Laboratory by Eric De Jong, Jeff Hall, Myche McAuley, and Randy Kirk of the United States Geological Survey, and is a single frame from the movie released at the May 29, 1991 Magellan news conference.

  20. Venus O2 visible and IR nightglow: Implications for lower thermosphere dynamics and chemistry (United States)

    Bougher, S. W.; Borucki, W. J.


    The National Center for Atmospheric Research thermospheric general circulation model for the Venus thermosphere is modified to examine two observed night airglow features, both of which serve as sensitive tracers of the thermospheric circulation. New O2 nightglow data from the Pioneer Venus Orbiter (PVO) star tracker (O2 Herzberg II at 400-800 nm) and ground-based telescopes (O2 IR at 1.27 microns) yield additional model constraints for estimating Venus winds over 100-130 km. Atomic oxygen, produced by dayside CO2 photolysis peaking near 110 km, and transported to the nightside by the global wind system, is partially destroyed through three-body recombination, yielding the O2 Herzberg II visible nightglow. This emission is very sensitive to horizontal winds at altitudes between 100 and 130 km. Other trace species catalytic reactions also contribute to the production of the very strong nightside infrared (1.27 microns) emission. This paper examines the dynamical and chemical implications of these new data using the Venus thermospheric general circulation model (VTGCM) as an analysis tool. Three-dimensional calculations are presented for both solar maximum and solar medium conditions, corresponding to early PVO (1979-1981) and PVO entry (mid-1992) time periods. Very distinct periods are identified in which zonal winds are alternately weak and strong in the Venus lower thermosphere. VTGCM sensitivity studies are conducted to assess the impacts of potential changes in thermospheric zonal and day-to-night winds, and eddy diffusion on the corresponding nightglow intensities. It appears that cyclostrophic balance extends above 80 km periodically, owing to a reversal of the upper mesosphere latitudinal tempe