Alcohol Facts and Statistics

Science.gov (United States)

... Standard Drink? Drinking Levels Defined Alcohol Facts and Statistics Print version Alcohol Use in the United States: ... 1238–1245, 2004. PMID: 15010446 National Center for Statistics and Analysis. 2014 Crash Data Key Findings (Traffic ...

Facts about Physical Activity

Science.gov (United States)

... Micronutrient Malnutrition State and Local Programs Facts about Physical Activity Recommend on Facebook Tweet Share Compartir Some Americans ... Activity Guideline for aerobic activity than older adults. Physical activity and socioeconomic status Adults with more education are ...

News Release: USDA Joins Fair Food Network, State and Local Partners to

Science.gov (United States)

vitamin C, calcium, and iron. The Food Bank of Eastern Michigan in Flint is distributing those USDA Foods Joins Fair Food Network, State and Local Partners to Promote Nutrition Resources for Lead-Affected Flint Residents News Release: USDA Joins Fair Food Network, State and Local Partners to Promote Nutrition

State Energy Program Fact Sheet

Energy Technology Data Exchange (ETDEWEB)

None

2018-02-01

The U.S. Department of Energy’s State Energy Program (SEP) provides funding and technical assistance to states, territories, and the District of Columbia to enhance energy security, advance state-led energy initiatives, and maximize the benefits of decreasing energy waste.

Epidemiology of Infectious Disease-Related Death After Release from Prison, Washington State, United States, and Queensland, Australia: A Cohort Study.

Science.gov (United States)

Binswanger, Ingrid A; Blatchford, Patrick J; Forsyth, Simon J; Stern, Marc F; Kinner, Stuart A

2016-01-01

People in prison may be at high risk for infectious diseases and have an elevated risk of death immediately after release compared with later; their risk of death is elevated for at least a decade after release. We compared rates, characteristics, and prison-related risk factors for infectious disease-related mortality among people released from prisons in Queensland, Australia, and Washington State, United States, regions with analogous available data. We analyzed data from retrospective cohort studies of people released from prison in Queensland (1997-2007, n=37,180) and Washington State (1999-2009, n=76,208) and linked identifiers from each cohort to its respective national death index. We estimated infectious disease-related mortality rates (deaths per person-years in community) and examined associations using Cox proportional hazard models. The most frequent infectious disease-related underlying cause of death after release from prison was pneumonia (43%, 23/54 deaths) in the Australian cohort and viral hepatitis (40%, 69/171 deaths) in the U.S. cohort. The infectious disease-related mortality rate was significantly higher in the U.S. cohort than in the Australian cohort (51.2 vs. 26.5 deaths per 100,000 person-years; incidence rate ratio = 1.93, 95% confidence interval 1.42, 2.62). In both cohorts, increasing age was strongly associated with mortality from infectious diseases. Differences in the epidemiology of infectious disease-related mortality among people released from prison may reflect differences in patterns of community health service delivery in each region. These findings highlight the importance of preventing and treating hepatitis C and other infectious diseases during the transition from prison to the community.

State and Local Clean Energy Policy Primer: Getting from Here to Clean Electricity with Policy (Fact Sheet)

Energy Technology Data Exchange (ETDEWEB)

2011-04-01

This fact sheet proposes a framework for how states and localities can build policy portfolios by first setting the stage for clean energy in the market with low cost policies, and then growing the market with successive policies until the need for financial incentives can be reduced and eventually eliminated.

Steady-state and transient fission gas release and swelling model for LIFE-4

International Nuclear Information System (INIS)

Villalobos, A.; Liu, Y.Y.; Rest, J.

1984-06-01

The fuel-pin modeling code LIFE-4 and the mechanistic fission gas behavior model FASTGRASS have been coupled and verified against gas release data from mixed-oxide fuels which were transient tested in the TREAT reactor. Design of the interface between LIFE-4 and FASTGRASS is based on an earlier coupling between an LWR version of LIFE and the GRASS-SST code. Fission gas behavior can significantly affect steady-state and transient fuel performance. FASTGRASS treats fission gas release and swelling in an internally consistent manner and simultaneously includes all major mechanisms thought to influence fission gas behavior. The FASTGRASS steady-state and transient analysis has evolved through comparisons of code predictions with fission-gas release and swelling data from both in- and ex-reactor experiments. FASTGRASS was chosen over other fission-gas behavior models because of its availability, its compatibility with the LIFE-4 calculational framework, and its predictive capability

Regulation of Ca2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides

Science.gov (United States)

Lehninger, Albert L.; Vercesi, Anibal; Bababunmi, Enitan A.

1978-01-01

Mitochondria from normal rat liver and heart, and also Ehrlich tumor cells, respiring on succinate as energy source in the presence of rotenone (to prevent net electron flow to oxygen from the endogenous pyridine nucleotides), rapidly take up Ca2+ and retain it so long as the pyridine nucleotides are kept in the reduced state. When acetoacetate is added to bring the pyridine nucleotides into a more oxidized state, Ca2+ is released to the medium. A subsequent addition of a reductant of the pyridine nucleotides such as β-hydroxybutyrate, glutamate, or isocitrate causes reuptake of the released Ca2+. Successive cycles of Ca2+ release and uptake can be induced by shifting the redox state of the pyridine nucleotides to more oxidized and more reduced states, respectively. Similar observations were made when succinate oxidation was replaced as energy source by ascorbate oxidation or by the hydrolysis of ATP. These and other observations form the basis of a hypothesis for feedback regulation of Ca2+-dependent substrate- or energy-mobilizing enzymatic reactions by the uptake or release of mitochondrial Ca2+, mediated by the cytosolic phosphate potential and the ATP-dependent reduction of mitochondrial pyridine nucleotides by reversal of electron transport. Images PMID:25436

9/11 and the War on Terror in Curricula and in State Standards Documents. CIRCLE Fact Sheet

Science.gov (United States)

Stoddard, Jeremy; Hess, Diana

2011-01-01

This Fact Sheet reports findings from an ongoing study of the representation of 9/11 and terrorism in curricula, textbooks, and state standards documents. The study was conducted in three stages. The first two stages focused on how supplemental curricula and best-selling social studies textbooks published between 2002-2010 present the events of…

Mixmaster: fact and belief

International Nuclear Information System (INIS)

Heinzle, J Mark; Uggla, Claes

2009-01-01

We consider the dynamics towards the initial singularity of Bianchi type IX vacuum and orthogonal perfect fluid models with a linear equation of state. Surprisingly few facts are known about the 'Mixmaster' dynamics of these models, while at the same time most of the commonly held beliefs are rather vague. In this paper, we use Mixmaster facts as a base to build an infrastructure that makes it possible to sharpen the main Mixmaster beliefs. We formulate explicit conjectures concerning (i) the past asymptotic states of type IX solutions and (ii) the relevance of the Mixmaster/Kasner map for generic past asymptotic dynamics. The evidence for the conjectures is based on a study of the stochastic properties of this map in conjunction with dynamical systems techniques. We use a dynamical systems formulation, since this approach has so far been the only successful path to obtain theorems, but we also make comparisons with the 'metric' and Hamiltonian 'billiard' approaches.

2008 public transportation fact book

Science.gov (United States)

2008-06-01

This Public Transportation Fact Book presents statistics describing the entire United States transit industry for 1995 : through 2006 with additional detail and overview presentations for 2006. Also included are definitions of reported data : items.

2010 public transportation fact book

Science.gov (United States)

2010-04-01

The Public Transportation Fact Book, published annually, contains national aggregate statistical data covering all aspects of the transit industry in the United States and Canada. Two appendices, also available, provide additional in-depth informatio...

Back Pain Facts and Statistics

Science.gov (United States)

... Marketing Patient Fact Sheets Contact the ACA State Licensing Boards Research JMPT Abstracts Latest Issue Evidence in ... Chiropractic Posture Backpack Safety Spinal Health Winter Activities Kids and Sports Exercising Outdoors with Baby Gardening Chronic ...

Facts about Volunteers. NCJW Center for the Child Fact Sheet Number 5.

Science.gov (United States)

National Council of Jewish Women, New York, NY. Center for the Child.

Volunteering is a vital and widespread activity in the United States; in fact, volunteers perform many essential community functions. Those who believe that most volunteers are women with time on their hands, that volunteers just do "charity work," and that volunteers are a source of cheap labor who can replace paid professionals and…

Monitoring water for radioactive releases in the United States

International Nuclear Information System (INIS)

Porter, C.R.; Broadway, J.A.; Kahn, B.

1990-01-01

The major radiological environmental monitoring programs for water in the United States are described. The applications of these programs for monitoring radioactive fallout, routine discharges from nuclear facilities, and releases due to accidents at such facilities are discussed, and some examples of measurements are presented. The programs monitor rainfall, surface water, and water supplies. Samples are usually collected and analyzed on a monthly or quarterly schedule, but the frequency is increased in response to emergencies. (author)

Facts about food irradiation: Safety of irradiation facilities

International Nuclear Information System (INIS)

1991-01-01

This fact sheet considers the safety of industrial irradiation facilities. Although there have been accidents, none of them has endangered public health or environmental safety, and the radiation processing industry is considered to have a very good safety record. Gamma irradiators do not produce radioactive waste, and the radiation sources at the facilities cannot explode nor in any other way release radioactivity into the environment. 3 refs

Drug Facts

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Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... home care. Take action. Become an advocate SPECIAL REPORT: FINANCIAL AND PERSONAL BENEFITS OF EARLY DIAGNOSIS Early ... State The 2018 Alzheimer's Disease Facts and Figures report contains data on the impact of this disease ...

Nickel and Cobalt Release From Children's Toys Purchased in Denmark and the United States

DEFF Research Database (Denmark)

Jensen, P.; Hamann, Dathan; Hamann, Carsten R.

2014-01-01

from children's toys. Methods : We purchased 212 toys in 18 different retail and online stores in the United States and Denmark. Nickel and cobalt release was tested using the dimethylglyoxime and cobalt screening spot tests. Results : A total of 73 toys (34.4%) released nickel, and none released......Background : Nickel is the most common allergen detected by patch testing in children. There is an increasing number of cases in children who have not had exposure to piercing. Although the clinical relevance of nickel patch test reactions in children is sometimes uncertain, continued vigilance...

Ethanol Basics (Fact Sheet)

Energy Technology Data Exchange (ETDEWEB)

2015-01-01

Ethanol is a widely-used, domestically-produced renewable fuel made from corn and other plant materials. More than 96% of gasoline sold in the United States contains ethanol. Learn more about this alternative fuel in the Ethanol Basics Fact Sheet, produced by the U.S. Department of Energy's Clean Cities program.

CERN Quick Facts 2017 (French version)

CERN Multimedia

Mobs, Esma

2017-01-01

Facts about CERN, the contributions of its Member States, its machines and experiments, the number of its employees and users, management structure, etc. Previously called "CERN General Information Sheet"

CERN Quick Facts 2016 (French version)

CERN Multimedia

AUTHOR|(CDS)2070305

2016-01-01

Facts about CERN, the contributions of its Member States, its machines and experiments, the number of its employees and users, management structure, etc. Previously called "CERN General Information Sheet"

CERN Quick Facts 2016 (English version)

CERN Multimedia

AUTHOR|(CDS)2070305

2016-01-01

Facts about CERN, the contributions of its Member States, its machines and experiments, the number of its employees and users, management structure, etc. Previously called "CERN General Information Sheet"

CERN Quick Facts 2017 (English version)

CERN Multimedia

Mobs, Esma

2017-01-01

Facts about CERN, the contributions of its Member States, its machines and experiments, the number of its employees and users, management structure, etc. Previously called "CERN General Information Sheet"

Drug Facts

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Gun Sales. Firearm Facts.

Science.gov (United States)

Duker, Laurie, Ed.

Minimal federal regulations on firearm sales have facilitated the proliferation of guns, gun owners, and gun dealers in the United States. This fact sheet offers data on the growing number of firearm dealers, the relative ease of obtaining and keeping a license to sell guns from the Federal Bureau of Alcohol, Tobacco, and Firearms, the lack of…

Creation, Storage, and On-Demand Release of Optical Quantum States with a Negative Wigner Function

Directory of Open Access Journals (Sweden)

Jun-ichi Yoshikawa

2013-12-01

Full Text Available Highly nonclassical quantum states of light, characterized by Wigner functions with negative values, have been all-optically created so far only in a heralded fashion. In this case, the desired output emerges rarely and randomly from a quantum-state generator. An important example is the heralded production of high-purity single-photon states, typically based on some nonlinear optical interaction. In contrast, on-demand single-photon sources are also reported, exploiting the quantized level structure of matter systems. These sources, however, lead to highly impure output states, composed mostly of vacuum. While such impure states may still exhibit certain single-photon-like features such as antibunching, they are not nonclassical enough for advanced quantum-information processing. On the other hand, the intrinsic randomness of pure, heralded states can be circumvented by first storing and then releasing them on demand. Here, we propose such a controlled release, and we experimentally demonstrate it for heralded single photons. We employ two optical cavities, where the photons are both created and stored inside one cavity and finally released through a dynamical tuning of the other cavity. We demonstrate storage times of up to 300 ns while keeping the single-photon purity around 50% after storage. Our experiment is the first demonstration of a negative Wigner function at the output of an on-demand photon source or a quantum memory. In principle, our storage system is compatible with all kinds of nonclassical states, including those known to be essential for many advanced quantum-information protocols.

Equations for estimating stand establishment, release, and thinning costs in the Lake States.

Science.gov (United States)

Jeffrey T. Olson; Allen L. Lundgren; Dietmar Rose

1978-01-01

Equations for estimating project costs for certain silvicultural treatments in the Lake States have been developed from project records of public forests. Treatments include machine site preparation, hand planting, aerial spraying, prescribed burning, manual release, and thinning.

Invasive plants and enemy release: Evolution of trait means and trait correlations in Ulex europaeus

OpenAIRE

Hornoy , Benjamin; Tarayre , Michèle; Hervé , Maxime; Gigord , Luc; Atlan , Anne

2011-01-01

International audience; Several hypotheses that attempt to explain invasive processes are based on the fact that plants have been introduced without their natural enemies. Among them, the EICA (Evolution of Increased Competitive Ability) hypothesis is the most influential. It states that, due to enemy release, exotic plants evolve a shift in resource allocation from defence to reproduction or growth. In the native range of the invasive species Ulex europaeus, traits involved in reproduction a...

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Drug Facts

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Full Text Available ... Facts Search form Search Menu Home Drugs That People Abuse Alcohol Facts Bath Salts Facts Cocaine (Coke, ... Drugs? Effects of Drugs Drug Use and Other People Drug Use and Families Drug Use and Kids ...

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Full Text Available ... Home Drugs That People Abuse Alcohol Facts Bath Salts Facts Cocaine (Coke, Crack) Facts Heroin (Smack, Junk) ... treatment. Watch Videos Information About Drugs Alcohol Bath Salts Cocaine Heroin Marijuana MDMA Meth Pain Medicines Spice ( ...

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Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers

Directory of Open Access Journals (Sweden)

Yoon S

2014-01-01

Full Text Available Seonghae Yoon,1,* Howard Lee,2,* Tae-Eun Kim,1 SeungHwan Lee,1 Dong-Hyun Chee,3 Joo-Youn Cho,1 Kyung-Sang Yu,1 In-Jin Jang1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 2Clinical Trials Center, Seoul National University Hospital, 3AbbVie Ltd., Seoul, Republic of Korea *These authors contributed equally to this work Background: This study was conducted to compare the oral bioavailability of an itopride extended-release (ER formulation with that of the reference immediate-release (IR formulation in the fasting state. The effect of food on the bioavailability of itopride ER was also assessed. Methods: A single-center, open-label, randomized, multiple-dose, three-treatment, three-sequence, crossover study was performed in 24 healthy male subjects, aged 22–48 years, who randomly received one of the following treatments for 4 days in each period: itopride 150 mg ER once daily under fasting or fed conditions, or itopride 50 mg IR three times daily in the fasting state. Steady-state pharmacokinetic parameters of itopride, including peak plasma concentration (Cmax and area under the plasma concentration versus time curve over 24 hours after dosing (AUC0–24h, were determined by noncompartmental analysis. The geometric mean ratio of the pharmacokinetic parameters was derived using an analysis of variance model. Results: A total of 24 healthy Korean subjects participated, 23 of whom completed the study. The geometric mean ratio and its 90% confidence interval of once-daily ER itopride versus IR itopride three times a day for AUC0–24h were contained within the conventional bioequivalence range of 0.80–1.25 (0.94 [0.88–1.01], although Cmax was reached more slowly and was lower for itopride ER than for the IR formulation. Food delayed the time taken to reach Cmax for itopride ER, but AUC0–24h was not affected. There were no serious adverse events and both formulations were

Young People and Political Campaigning on the Internet. CIRCLE Fact Sheet.

Science.gov (United States)

Levine, Peter; Lopez, Mark Hugo

2004-01-01

This fact sheet discusses young people and political campaigning on the Internet. It explains how the Internet has become a powerful force in political campaigns. A survey released by the Pew Research Center for the People & the Press on January 11, 2004 found that the Internet is gaining importance as a source of political news, especially for…

International nuclear cycle fact book: Revision 9

International Nuclear Information System (INIS)

Leigh, I.W.

1989-01-01

The International Nuclear Fuel Cycle Fact Book has been compiled in an effort to provide current data concerning fuel cycle and waste management facilities, R and D programs and key personnel. The Fact Book contains: national summaries in which a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; and international agencies in which a section for each of the international agencies which has significant fuel cycle involvement, and a listing of nuclear societies. The national summaries, in addition to the data described above, feature a small map for each country as well as some general information. The latter is presented from the perspective of the Fact Book user in the United States

International nuclear fuel cycle fact book

International Nuclear Information System (INIS)

1992-09-01

The International Nuclear Fuel Cycle Fact Book has been compiled in an effort to provide current data concerning fuel cycle and waste management facilities, R ampersand D programs and key personnel on 23 countries, including the US, four multi-national agencies, and 21 nuclear societies. The Fact Book is organized as follows: National summaries-a section for each country which summarizes nuclear policy, describes organizational relationships, and provides addresses and names of key personnel and information on facilities. International agencies-a section for each of the international agencies which has significant fuel cycle involvement and a listing of nuclear societies. Glossary-a list of abbreviations/acronyms of organizations, facilities, technical and other terms. The national summaries, in addition to the data described above, feature a small map for each country as well as some general information. The latter presented from the perspective of the Fact Book user in the United States

Oral Health in the US: Key Facts

Science.gov (United States)

... national health issues… Prescription Drugs Waivers Puerto Rico/Virgin Islands Recovery Disparities Policy Search Graphics & Interactives Polls ... Medicare Private Insurance Uninsured Women’s Health Policy Nav Group Polling Perspectives State Health Facts Graphics & Interactives Charts & ...

48 CFR 750.7109-3 - Facts and evidence.

Science.gov (United States)

2010-10-01

... CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS Extraordinary Contractual Actions To Protect Foreign Policy Interests of the United States 750.7109-3 Facts and evidence. The contracting officer or the...

Get the Facts: Drinking Water and Intake

Science.gov (United States)

... Obesity About Us Nutrition Physical Activity Overweight & Obesity Healthy Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Related Links CDC Food Safety Adolescent and School Health BAM! Body and Mind Get the Facts: Drinking Water and Intake Recommend ...

Dams release methane even in temperate zoned

International Nuclear Information System (INIS)

Lemarchand, F.

2010-01-01

The Wohlen lake (near Bern) is a retaining dam built 90 years ago that has undergone a campaign to measure the quantity of methane released. The campaign lasted 1 year and the result was unexpected: 0.15 g/m 2 *day which one of the highest release rates in temperate zones. This result is all the more stunning since water stays only 2 days in average in the reservoir and that the drowned area is not important. In fact the river Aar that feeds the lake is loaded with organic matter coming from humane activities: agriculture and 3 sewage plants. This organic matter decays in the lake releasing methane. (A.C.)

Fact Sheets on Pesticides in Schools.

Science.gov (United States)

National Coalition against the Misuse of Pesticides, Washington, DC.

This document consists of a collection of fact sheets about the use of pesticides in schools and how to reduce it. The sheets are: (1) "Alternatives to Using Pesticides in Schools: What Is Integrated Pest Management?"; (2) "Health Effects of 48 Commonly Used Pesticides in Schools"; (3) "The Schooling of State Pesticide…

Nickel and cobalt release from children's toys purchased in Denmark and the United States.

Science.gov (United States)

Jensen, Peter; Hamann, Dathan; Hamann, Carsten R; Jellesen, Morten S; Jacob, Sharon E; Thyssen, Jacob P

2014-01-01

Nickel is the most common allergen detected by patch testing in children. There is an increasing number of cases in children who have not had exposure to piercing. Although the clinical relevance of nickel patch test reactions in children is sometimes uncertain, continued vigilance to identify new sources of nickel exposure in this age group is important. Recent case reports have described allergic nickel contact dermatitis in children following exposure to toys, but the magnitude of this problem is unknown. The aim of this study was to evaluate nickel and cobalt release from children's toys. We purchased 212 toys in 18 different retail and online stores in the United States and Denmark. Nickel and cobalt release was tested using the dimethylglyoxime and cobalt screening spot tests. A total of 73 toys (34.4%) released nickel, and none released cobalt. Toys are a commonly overlooked source of nickel exposure and sensitization. Therefore, dermatologists, allergists, and pediatricians should consider the role of toys in their evaluation of children with dermatitis, and the parents of children with positive nickel patch test reactions should be told that toys may release nickel and be a potential chemical source in the manifestation of allergic contact dermatitis.

International nuclear fuel cycle fact book: Revision 9

Energy Technology Data Exchange (ETDEWEB)

Leigh, I.W.

1989-01-01

The International Nuclear Fuel Cycle Fact Book has been compiled in an effort to provide current data concerning fuel cycle and waste management facilities, R and D programs and key personnel. The Fact Book contains: national summaries in which a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; and international agencies in which a section for each of the international agencies which has significant fuel cycle involvement, and a listing of nuclear societies. The national summaries, in addition to the data described above, feature a small map for each country as well as some general information. The latter is presented from the perspective of the Fact Book user in the United States.

Controlled release of cavity states into propagating modes induced via a single qubit

Science.gov (United States)

Pfaff, Wolfgang; Constantin, Marius; Reagor, Matthew; Axline, Christopher; Blumoff, Jacob; Chou, Kevin; Leghtas, Zaki; Touzard, Steven; Heeres, Reinier; Reinhold, Philip; Ofek, Nissim; Sliwa, Katrina; Frunzio, Luigi; Mirrahimi, Mazyar; Lehnert, Konrad; Jiang, Liang; Devoret, Michel; Schoelkopf, Robert

Photonic states stored in long-lived cavities are a promising platform for scalable quantum computing and for the realization of quantum networks. An important aspect in such a cavity-based architecture will be the controlled conversion of stored photonic states into propagating ones. This will allow, for instance, quantum state transfer between remote cavities. We demonstrate the controlled release of quantum states from a microwave resonator with millisecond lifetime in a 3D circuit QED system. Dispersive coupling of the cavity to a transmon qubit allows us to enable a four-wave mixing process that transfers the stored state into a second resonator from which it can leave the system through a transmission line. This permits us to evacuate the cavity on time scales that are orders of magnitude faster than the intrinsic lifetime. This Q-switching process can in principle be fully coherent, making our system highly promising for quantum state transfer between nodes in a quantum network of high-Q cavities.

Disintegration mediated controlled release supersaturating solid dispersion formulation of an insoluble drug: design, development, optimization, and in vitro evaluation.

Science.gov (United States)

Verma, Sanjay; Rudraraju, Varma S

2015-02-01

The objective of this study was to develop a solid dispersion based controlled release system for drug substances that are poorly soluble in water. A wax-based disintegration mediated controlled release system was designed based on the fact that an amorphous drug can crystallize out from hydrophilic matrices. For this study, cilostazol (CIL) was selected as the model drug, as it exhibits poor aqueous solubility. An amorphous solid dispersion was prepared to assist the drug to attain a supersaturated state. Povidone was used as carrier for solid dispersion (spray drying technique), hydrogenated vegetable oil (HVO) as wax matrix former, and sodium carboxymethyl cellulose (NaCMC) as a disintegrant. The extreme vertices mixture design (EVMD) was applied to optimize the designed and developed composition. The optimized formulation provided a dissolution pattern which was equivalent to the predicted curve, ascertaining that the optimal formulation could be accomplished with EVMD. The release profile of CIL was described by the Higuchi's model better than zero-order, first-order, and Hixson-Crowell's model, which indicated that the supersaturation state of CIL dominated to allow drug release by diffusion rather than disintegration regulated release as is generally observed by Hixson-Crowell's model. The optimized composition was evaluated for disintegration, dissolution, XRD, and stability studies. It was found that the amorphous state as well as the dissolution profile of CIL was maintained under the accelerated conditions of 40°C/75% RH for 6 months.

Metal lost and found: dissipative uses and releases of copper in the United States 1975-2000.

Science.gov (United States)

Lifset, Reid J; Eckelman, Matthew J; Harper, E M; Hausfather, Zeke; Urbina, Gonzalo

2012-02-15

Metals are used in a variety of ways, many of which lead to dissipative releases to the environment. Such releases are relevant from both a resource use and an environmental impact perspective. We present a historical analysis of copper dissipative releases in the United States from 1975 to 2000. We situate all dissipative releases in copper's life cycle and introduce a conceptual framework by which copper dissipative releases may be categorized in terms of intentionality of use and release. We interpret our results in the context of larger trends in production and consumption and government policies that have served as drivers of intentional copper releases from the relevant sources. Intentional copper releases are found to be both significant in quantity and highly variable. In 1975, for example, the largest source of intentional releases was from the application of copper-based pesticides, and this decreased more than 50% over the next 25 years; all other sources of intentional releases increased during that period. Overall, intentional copper releases decreased by approximately 15% from 1975 to 2000. Intentional uses that are unintentionally released such as copper from roofing, increased by the same percentage. Trace contaminant sources such as fossil fuel combustion, i.e., sources where both the use and the release are unintended, increased by nearly 50%. Intentional dissipative uses are equivalent to 60% of unintentional copper dissipative releases and more than five times that from trace sources. Dissipative copper releases are revealed to be modest when compared to bulk copper flows in the economy, and we introduce a metric, the dissipation index, which may be considered an economy-wide measure of resource efficiency for a particular substance. We assess the importance of dissipative releases in the calculation of recycling rates, concluding that the inclusion of dissipation in recycling rate calculations has a small, but discernible, influence, and should

Drug Facts

Medline Plus

Full Text Available ... to main content Easy-to-Read Drug Facts Search form Search Menu Home Drugs That People Abuse Alcohol Facts ... Past Drug Use Prevention Phone Numbers and Websites Search Share Listen English Español Information about this page ...

Power system stability enhancement using facts controllers: a review

International Nuclear Information System (INIS)

Abido, M. A

2009-01-01

In recent years, power demand has increased substantially while the expansion of power generation and transmission has been severely limited due to limited resources and environmental restrictions. As a consequence, some transmission lines are heavily loaded and the system stability becomes a power transfer-limiting factor. Flexible AC transmission systems (FACTS) controllers have been mainly used for solving various power system steady state control problems. However, recent studies reveal that FACTS controllers could be employed to enhance power system stability in addition to their main function of power flow control. The literature shows an increasing interest in this subject for the last two decades, where the enhancement of system stability using FACTS controllers has been extensively investigated. This paper presents a comprehensive review on the research and developments in the power system stability enhancement using FACTS damping controllers. Several technical issues related to FACTS installations have been highlighted and performance comparison of different FACTS controllers has been discussed. In addition, some of the utility experience, real-world installations, and semiconductor technology development have been reviewed and summarized. Applications of FACTS to other power system studies have also been discussed. About two hundred twenty seven research publications have been classified and appended for a quick reference. (author)

Historical Review of the Transportation Analysis Fact of the Week, 1996-2017

Energy Technology Data Exchange (ETDEWEB)

Gohlke, David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Davis, Stacy Cagle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-10-01

The Vehicle Technologies Office in the United States Department of Energy hosts a transportation analysis fact of the week on its webpage. As of October 2017, one thousand facts have been published since 1996. Examining the themes of published facts allows one to trace analytical trends determined to be of interest to the public over this time. The most popular themes addressed in the Fact of the Week were vehicle fuel economy, petroleum use and production, vehicle sales, and traveler behavior. Facts on vehicle electrification and advanced combustion technologies have been more popular in the last few years, showing their relevance to the Department of Energy mission.

Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers.

Science.gov (United States)

Yoon, Seonghae; Lee, Howard; Kim, Tae-Eun; Lee, SeungHwan; Chee, Dong-Hyun; Cho, Joo-Youn; Yu, Kyung-Sang; Jang, In-Jin

2014-01-01

This study was conducted to compare the oral bioavailability of an itopride extended-release (ER) formulation with that of the reference immediate-release (IR) formulation in the fasting state. The effect of food on the bioavailability of itopride ER was also assessed. A single-center, open-label, randomized, multiple-dose, three-treatment, three-sequence, crossover study was performed in 24 healthy male subjects, aged 22-48 years, who randomly received one of the following treatments for 4 days in each period: itopride 150 mg ER once daily under fasting or fed conditions, or itopride 50 mg IR three times daily in the fasting state. Steady-state pharmacokinetic parameters of itopride, including peak plasma concentration (Cmax) and area under the plasma concentration versus time curve over 24 hours after dosing (AUC(0-24h)), were determined by noncompartmental analysis. The geometric mean ratio of the pharmacokinetic parameters was derived using an analysis of variance model. A total of 24 healthy Korean subjects participated, 23 of whom completed the study. The geometric mean ratio and its 90% confidence interval of once-daily ER itopride versus IR itopride three times a day for AUC(0-24h) were contained within the conventional bioequivalence range of 0.80-1.25 (0.94 [0.88-1.01]), although Cmax was reached more slowly and was lower for itopride ER than for the IR formulation. Food delayed the time taken to reach Cmax for itopride ER, but AUC(0-24h) was not affected. There were no serious adverse events and both formulations were generally well tolerated. At steady state, once-daily itopride ER at 150 mg has a bioavailability comparable with that of itopride IR at 50 mg given three times a day under fasting conditions. Food delayed the absorption of itopride ER, with no marked change in its oral bioavailability.

Accidental hazardous material releases with human impacts in the United States: exploration of geographical distribution and temporal trends.

Science.gov (United States)

Sengul, Hatice; Santella, Nicholas; Steinberg, Laura J; Chermak, Christina

2010-09-01

To investigate the circumstances and geographic and temporal distributions of hazardous material releases and resulting human impacts in the United States. Releases with fatalities, injuries, and evacuations were identified from reports to the National Response Center between 1990 and 2008, correcting for data quality issues identified in previous studies. From more than 550,000 reports, 861 deaths, 16,348 injuries and 741,427 evacuations were identified. Injuries from releases of chemicals at fixed facilities and natural gas from pipelines have decreased whereas evacuations from petroleum releases at fixed facilities have increased. Results confirm recent advances in chemical and pipeline safety and suggest directions for further improvement including targeted training and inspections and adoption of inherently safer design principles.

Health impacts of coal: facts and fallacies

Energy Technology Data Exchange (ETDEWEB)

Finkelman, R.B. [University of Texas, Dallas, TX (United States)

2007-02-15

Coal has contributed enormously to the advance of civilization by providing an abundant, inexpensive, and convenient source of energy. Concurrent with its contributions, coal has extracted a high cost in terms of environmental damage and human health impacts. Unfortunately, the links between coal use and human health are distorted by a great deal of ignorance and misinformation. This paper discusses the facts and fallacies of the direct health impacts caused by coal. These include health problems caused by arsenic, fluorine, mercury and selenium released in coal use in the residential sector. The trace element iodine however may help prevent iodine deficiency disorder. Lignite in the ground in some Balkan areas has been associated with a urinary tract cancer known as Balkan endemic nephropathy (BEN). Uncontrolled burning coal seams and coal waste piles contribute to global warming and to respiratory problems. The 10-fold enrichment of trace elements in fly ash and the fine particles released from power plants could present a health threat but where good pollution control technology and disposal practices are applied the health threat is probably minimal. Radioactivity levels in coal are thought to be too low to cause concern. 27 refs., 2 figs.

Fact Sheet: Clean Air Act Section 112(r): Accidental Release Prevention / Risk Management Plan Rule

Science.gov (United States)

EPA is required to publish regulations and guidance for chemical accident prevention at facilities that pose the greatest risk of harm from accidental releases of regulated flammable and toxic substances above threshold quantities.

Physico-chemical state influences in vitro release profile of curcumin from pectin beads.

Science.gov (United States)

Nguyen, An Thi-Binh; Winckler, Pascale; Loison, Pauline; Wache, Yves; Chambin, Odile

2014-09-01

Curcumin is a polyphenolic compound with diverse effects interesting to develop health benefit products but its formulation in functional foods or in food supplement is hampered by its poor water solubility and susceptibility to alkaline conditions, light, oxidation and heat. Encapsulation of curcumin could be a mean to overcome these difficulties. In this paper, curcumin was encapsulated by ionotropic gelation method in low methoxyl pectin beads associated with different surfactants: Solutol(®), Transcutol(®) and sodium caseinate. After encapsulation, physico-chemical properties of encapsulated curcumin such as its solubility, physical state, tautomeric forms and encapsulation efficiency as well as encapsulation yield were characterized. In vitro dissolution of curcumin from beads displayed different kinetic profiles according to bead composition due to different matrix network. As Solutol(®) was a good solvent for curcumin, the drug was present into amorphous form in these beads inducing a rapid release of curcumin in the simulated digestive fluids. In contrast, drug release was slower from sodium caseinate beads since curcumin was not totally dissolved during the manufacturing process. Moreover, the FLIM studies showed that a part of curcumin was encapsulated in caseinate micelles and that 34% of this drug was in keto form which may delay the curcumin release. The Transcutol beads showed also a slow drug release because of the low curcumin solubility and the high density of the matrix. Copyright © 2014 Elsevier B.V. All rights reserved.

Nuclear economics: Issues and facts

International Nuclear Information System (INIS)

Hudson, C.R.

1993-01-01

Nuclear economics has become on the more prominent topics related to nuclear power. Beyond the subjects of nuclear safety and waste disposal, questions and concerns of nuclear power economics have emerged with growing frequency in utility board rooms, in state and federal regulatory proceedings, and in the media. What has caused nuclear power economics to become such a popular topic? This paper addresses issues and facts related to historical nuclear plant costs, new nuclear plant projections, and warning signals for future plants

Biophysical and Biochemical Mechanisms in Synaptic Transmitter Release.

Science.gov (United States)

1992-01-31

vesicle is normally released per active zone Sci USA 83. 3032 (1986) pared (15, 19, 20). In fact, in squid, the quantum 8 0 Shimomura 8 Musicki. V Kisni...8217, AND R. LLINAS• *Instituto de Biologia Celular Facultad de Medicina. Universidad de Buenos Aires. Paraguay 2155. Buenos Aires 1121. Argentina: and

Primary system fission product release and transport. A state-of-the-art report to the committee on the safety of nuclear installations

International Nuclear Information System (INIS)

Wright, A.L.

1994-06-01

This report presents a summary of the status of research activities associated with fission product behavior (release and transport) under severe accident conditions within the primary systems of water-moderated and water-cooled nuclear reactors. For each of the areas of fission product release and fission product transport, the report summarizes relevant information on important phenomena, major experiments performed, relevant computer models and codes, comparisons of computer code calculations with experimental results, and general conclusions on the overall state of the art. Finally, the report provides an assessment of the overall importance and knowledge of primary system release and transport phenomena and presents major conclusions on the state of the art

Primary system fission product release and transport: A state-of-the-art report to the committee on the safety of nuclear installations

International Nuclear Information System (INIS)

Wright, A.L.

1994-06-01

This report presents a summary of the status of research activities associated with fission product behavior (release and transport) under severe accident conditions within the primary systems of water-moderated and water-cooled nuclear reactors. For each of the areas of fission product release and fission product transport, the report summarizes relevant information on important phenomena, major experiments performed, relevant computer models and codes, comparisons of computer code calculations with experimental results, and general conclusions on the overall state of the art. Finally, the report provides an assessment of the overall importance and knowledge of primary system release and transport phenomena and presents major conclusions on the state of the art

Primary system fission product release and transport: A state-of-the-art report to the committee on the safety of nuclear installations

Energy Technology Data Exchange (ETDEWEB)

Wright, A.L. [Oak Ridge National Lab., TN (United States)

1994-06-01

This report presents a summary of the status of research activities associated with fission product behavior (release and transport) under severe accident conditions within the primary systems of water-moderated and water-cooled nuclear reactors. For each of the areas of fission product release and fission product transport, the report summarizes relevant information on important phenomena, major experiments performed, relevant computer models and codes, comparisons of computer code calculations with experimental results, and general conclusions on the overall state of the art. Finally, the report provides an assessment of the overall importance and knowledge of primary system release and transport phenomena and presents major conclusions on the state of the art.

GRASS-SST, Fission Products Gas Release and Fuel Swelling in Steady-State and Transients

International Nuclear Information System (INIS)

Zawadzki, S.

2001-01-01

1 - Description of program or function: GRASS-SST is a comprehensive, mechanistic model for the prediction of fission-gas behaviour in UO 2 -base fuels during steady-state and transient conditions. GRASS-SST treats fission-gas release and fuel swelling on an equal basis and simultaneously treats all major mechanisms that influence fission-gas behaviour. Models are included for intra- and inter-granular fission-gas bubble behaviour as well as a mechanistic description of the role of grain-edge inter-linked porosity on fission-gas release and swelling. GRASS-SST calculations include the effects of gas production from fissioning uranium atoms, bubble nucleation, a realistic equation of state for xenon, lattice bubble diffusivities based on experimental observations, bubble migration, bubble coalescence, re-solution, temperature and temperature gradients, inter-linked porosity, and fission-gas interaction with structural defects (dislocations and grain boundaries) on both the distribution of fission-gas within the fuel and on the amount of fission-gas released from the fuel. GRASS-SST includes the effects of the degree of nonequilibrium in the UO 2 lattice on fission-gas bubble mobility and bubble coalescence and also accounts for the observed formation of grain-surface channels. GRASS-SST also includes mechanistic models for grain-growth/grain boundary sweeping and for the behaviour of fission gas during liquefaction/dissolution and fuel melting conditions. 2 - Method of solution: A system of coupled equations for the evolution of the fission-gas bubble-size distributions in the lattice, on dislocations, on grain faces, and grain edges is derived based on the GRASS-SST models. Given a set of operating conditions, GRASS-SST calculates the bubble radii for the size classes of bubbles under consideration using a realistic equation of state for xenon as well as a generalised capillary relation. 3 - Restrictions on the complexity of the problem: Maxima of : 1 axial section

Marine fouling release silicone/carbon nanotube nanocomposite coatings: on the importance of the nanotube dispersion state.

Science.gov (United States)

Beigbeder, Alexandre; Mincheva, Rosica; Pettitt, Michala E; Callow, Maureen E; Callow, James A; Claes, Michael; Dubois, Philippe

2010-05-01

The present work reports on the influence of the dispersion quality of multiwall carbon nanotubes (MWCNTs) in a silicone matrix on the marine fouling-release performance of the resulting nanocomposite coatings. A first set of coatings filled with different nanofiller contents was prepared by the dilution of a silicone/MWCNTs masterbatch within a hydrosilylation-curing polydimethylsiloxane resin. The fouling-release properties of the nanocomposite coatings were studied through laboratory assays with the marine alga (seaweed) Ulva, a common fouling species. As reported previously (see Ref. [19]), the addition of a small (0.05%) amount of carbon nanotubes substantially improves the fouling-release properties of the silicone matrix. This paper shows that this improvement is dependent on the amount of filler, with a maximum obtained with 0.1 wt% of multiwall carbon nanotubes (MWCNTs). The method of dispersion of carbon nanotubes in the silicone matrix is also shown to significantly (p = 0.05) influence the fouling-release properties of the coatings. Dispersing 0.1% MWCNTs using the masterbatch approach yielded coatings with circa 40% improved fouling-release properties over those where MWCNTs were dispersed directly in the polymeric matrix. This improvement is directly related to the state of nanofiller dispersion within the cross-linked silicone coating.

Facts about Glaucoma

Science.gov (United States)

... Information » Glaucoma » Facts About Glaucoma Listen Facts About Glaucoma This information was developed by the National Eye ... is the best person to answer specific questions. Glaucoma Defined What is Glaucoma? Glaucoma is a group ...

SunShot Initiative Fact Sheet

Energy Technology Data Exchange (ETDEWEB)

DOE Solar Energy Technologies Office

2015-04-01

The U.S. Department of Energy (DOE) SunShot Initiative is a collaborative national effort launched in 2011 that aggressively drives innovation to make solar energy fully cost competitive with traditional energy sources before the end of the decade. The SunShot fact sheet outlines goals and successes of the program as it works with private companies, universities, non-profit organizations, state and local governments, and national laboratories to drive down the cost of solar electricity to $0.06 per kilowatt-hour, without incentives, by the year 2020.

Facts about food irradiation. A series of fact sheets from the International Consultative Group on Food Irradiation

Energy Technology Data Exchange (ETDEWEB)

NONE

1991-12-01

The safety and benefits of foods processed by ionizing radiation are well documented. In an effort to provide governments, especially those of developing countries, with scientifically accurate information on issues of general interest to the public, the International Consultative Group on Food Irradiation (ICGFI), which was established under the aegis of the Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), and the IAEA, decided at its 7th Annual Meeting in Rome, Italy, on October 1990, to issue a series of ''Fact Sheets'' on the subject. ICGFI, an inter-governmental body with a membership of 37 governments, has as one of its mandates the function to provide information to Member States of the FAO, WHO, and IAEA and to the three organizations themselves on the safe and proper use of food irradiation technology. The Fact Sheets included here cover issues relating to: status and trends; scientific and technical terms; food irradiation and radioactivity; chemical changes in irradiated food; nutritional quality of irradiated foods; genetic studies; microbiological safety of irradiated food; irradiation and food safety; irradiation and food additives and residues; packaging of irradiated foods; safety of irradiation facilities; controlling the process; food irradiation costs; and irradiated foods and the consumer. The Fact Sheets have been separately indexed and included in the INIS Database under Reference Numbers 23011206-23011217, 23011319 and 23012743. The Fact Sheets were first issued by the ICGFI Secretariat (Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria) in May 1991.

Facts about food irradiation. A series of fact sheets from the International Consultative Group on Food Irradiation

International Nuclear Information System (INIS)

1991-12-01

The safety and benefits of foods processed by ionizing radiation are well documented. In an effort to provide governments, especially those of developing countries, with scientifically accurate information on issues of general interest to the public, the International Consultative Group on Food Irradiation (ICGFI), which was established under the aegis of the Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), and the IAEA, decided at its 7th Annual Meeting in Rome, Italy, on October 1990, to issue a series of ''Fact Sheets'' on the subject. ICGFI, an inter-governmental body with a membership of 37 governments, has as one of its mandates the function to provide information to Member States of the FAO, WHO, and IAEA and to the three organizations themselves on the safe and proper use of food irradiation technology. The Fact Sheets included here cover issues relating to: status and trends; scientific and technical terms; food irradiation and radioactivity; chemical changes in irradiated food; nutritional quality of irradiated foods; genetic studies; microbiological safety of irradiated food; irradiation and food safety; irradiation and food additives and residues; packaging of irradiated foods; safety of irradiation facilities; controlling the process; food irradiation costs; and irradiated foods and the consumer. The Fact Sheets have been separately indexed and included in the INIS Database under Reference Numbers 23011206-23011217, 23011319 and 23012743. The Fact Sheets were first issued by the ICGFI Secretariat (Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria) in May 1991

Hazard of radioactive releases resulted from coal burning

International Nuclear Information System (INIS)

Gabbard, V.

1995-01-01

Consideration is given to the data, pointing to the fact, that coal-burning power plants release of radioactive substances, contained in gaseous wastes, is not less, than the same one of nuclear power plants. The necessity of regulating emission of these substance in atmosphere by analogy with nuclear power industry is shown. 1 fig

Anatomy of the Lockerbie bombing: Libya’s role and reactions to al-Megrahi’s release.

Directory of Open Access Journals (Sweden)

K. J. Ani

2015-04-01

Full Text Available Despite its long historical antecedents, terrorism is amongst the growing realities of the national history of contemporary sovereign states. With this emergence, destabilizing influence, and internationalization, terrorism has made the associated security challenge a major diplomatic headache for all key international actors and diplomats. This paper, which adopts a theoretical approach, assesses claims that Ghadafi’s Libya championed state-sponsored terrorism. It reviews the Lockerbie bombing and the conviction of al-Megrahi by the court in Netherland as well as his release from Scottish prison on compassionate grounds. It examines Libya’s use of available diplomatic tools and channels not only to prevent Abdelbaset Ali Mohammed al-Megrahi from facing justice but also to attain Ghadafi’s political and economic interests. This article documents the political communication that followed his release and calls for increased diplomatic investigations of the Lockerbie terrorist attack. Finally, the paper beckons on Libya’s new leaders and the leaderships of USA and Scotland to engage in a progressive multilateral strategic cooperation to unravel further facts on the Lockerbie bombing while promoting the current international “war” against terrorism

Accelerated in-vitro release testing methods for extended-release parenteral dosage forms.

Science.gov (United States)

Shen, Jie; Burgess, Diane J

2012-07-01

This review highlights current methods and strategies for accelerated in-vitro drug release testing of extended-release parenteral dosage forms such as polymeric microparticulate systems, lipid microparticulate systems, in-situ depot-forming systems and implants. Extended-release parenteral dosage forms are typically designed to maintain the effective drug concentration over periods of weeks, months or even years. Consequently, 'real-time' in-vitro release tests for these dosage forms are often run over a long time period. Accelerated in-vitro release methods can provide rapid evaluation and therefore are desirable for quality control purposes. To this end, different accelerated in-vitro release methods using United States Pharmacopeia (USP) apparatus have been developed. Different mechanisms of accelerating drug release from extended-release parenteral dosage forms, along with the accelerated in-vitro release testing methods currently employed are discussed. Accelerated in-vitro release testing methods with good discriminatory ability are critical for quality control of extended-release parenteral products. Methods that can be used in the development of in-vitro-in-vivo correlation (IVIVC) are desirable; however, for complex parenteral products this may not always be achievable. © 2012 The Authors. JPP © 2012 Royal Pharmaceutical Society.

Accelerated in vitro release testing methods for extended release parenteral dosage forms

Science.gov (United States)

Shen, Jie; Burgess, Diane J.

2012-01-01

Objectives This review highlights current methods and strategies for accelerated in vitro drug release testing of extended release parenteral dosage forms such as polymeric microparticulate systems, lipid microparticulate systems, in situ depot-forming systems, and implants. Key findings Extended release parenteral dosage forms are typically designed to maintain the effective drug concentration over periods of weeks, months or even years. Consequently, “real-time” in vitro release tests for these dosage forms are often run over a long time period. Accelerated in vitro release methods can provide rapid evaluation and therefore are desirable for quality control purposes. To this end, different accelerated in vitro release methods using United States Pharmacopoeia (USP) apparatus have been developed. Different mechanisms of accelerating drug release from extended release parenteral dosage forms, along with the accelerated in vitro release testing methods currently employed are discussed. Conclusions Accelerated in vitro release testing methods with good discriminatory ability are critical for quality control of extended release parenteral products. Methods that can be used in the development of in vitro-in vivo correlation (IVIVC) are desirable, however for complex parenteral products this may not always be achievable. PMID:22686344

Controlled-release tablet formulation of isoniazid.

Science.gov (United States)

Jain, N K; Kulkarni, K; Talwar, N

1992-04-01

Guar (GG) and Karaya gums (KG) alone and in combination with hydroxy-propylmethylcellulose (HPMC) were evaluated as release retarding materials to formulate a controlled-release tablet dosage form of isoniazid (1). In vitro release of 1 from tablets followed non-Fickian release profile with rapid initial release. Urinary excretion studies in normal subjects showed steady-state levels of 1 for 13 h. In vitro and in vivo data correlated (r = 0.9794). The studies suggested the potentiality of GG and KG as release retarding materials in formulating controlled-release tablet dosage forms of 1.

2015 TRI National Analysis: Toxics Release Inventory Releases at Various Summary Levels

Science.gov (United States)

The TRI National Analysis is EPA's annual interpretation of TRI data at various summary levels. It highlights how toxic chemical wastes were managed, where toxic chemicals were released and how the 2015 TRI data compare to data from previous years. This dataset reports US state, county, large aquatic ecosystem, metro/micropolitan statistical area, and facility level statistics from 2015 TRI releases, including information on: number of 2015 TRI facilities in the geographic area and their releases (total, water, air, land); population information, including populations living within 1 mile of TRI facilities (total, minority, in poverty); and Risk Screening Environmental Indicators (RSEI) model related pounds, toxicity-weighted pounds, and RSEI score. The source of administrative boundary data is the 2013 cartographic boundary shapefiles. Location of facilities is provided by EPA's Facility Registry Service (FRS). Large Aquatic Ecosystems boundaries were dissolved from the hydrologic unit boundaries and codes for the United States, Puerto Rico, and the U.S. Virgin Islands. It was revised for inclusion in the National Atlas of the United States of America (November 2002), and updated to match the streams file created by the USGS National Mapping Division (NMD) for the National Atlas of the United States of America.

FACTS controllers and the deregulated electric utility environment

International Nuclear Information System (INIS)

Ooi, B. T.; Galiana, F. D.; McGillis, D.; Joos, G.; Marceau, R.

1998-01-01

The concept of Flexible AC Transmission Systems (FACTS) is explored and the potential of power electronic converters to increase flexibility and reliability of modern power systems is explored. Power electronic controllers can reduce the required safety margin in electric power generation capacity through the use of faster controllers based on exploiting the high-power solid-state switches with gate-turn-off capabilities. The FACTS concept makes it possible to postpone the financial investment needed to build more power lines, and also offers a solution to securing the right-of-way to build new lines. Currently available FACTS controllers such as the Static var Compensator (STATCOM) and the Unified Power Flow Controller (UPFC) are described, including their function, structure and relevant implementation issues. Since they can produce the required amount of reactive power independently of line voltage or current, and if equipped with energy storing devices they can supply real power as required, they are a necessary element for the control of power systems in a deregulated environment. 15 refs., 3 figs

Location of facts devices from a dynamic perspective; Ubicacion de dispositivos FACTS desde una perspectiva dinamica

Energy Technology Data Exchange (ETDEWEB)

Coronado Gallegos, Ixtlahuatl

2001-09-15

In this work techniques for the location of FACTS devices (Flexible Systems of AC Transmission) in a multi-machine power system in order to improve the electromechanical transient behavior is presented. In the first part, a brief introduction is presented about the FACTS devices, in which are mentioned some of the main characteristics, classification and advantages that their utilization represents. In the next part, the formulation of the matrix of state in the context of machine-infinite bar considering the possibility of including a power system stabilizer is developed. Later the formulation is extended to a multi-machine system. Additionally the form of including a series capacitor controlled by thyristors (TCSC) as well as a unified controller of power flows (UPFC) is analyzed. An analysis of the UPFC is carried out in conditions of stationary and dynamic state in a system machine-infinite bar in order to know its operating characteristics and its capacity for dampening power oscillations through its entrances of control when using local signals. In the last part of the work a methodology is proposed to attack the problem of the location of FACTS devices, which is based in the technique of response to the system frequency. In order to validate this proposal some cases of study are used and the results obtained with the ones provided by other techniques are compared. Also some auxiliary means are proposed for obtaining the feasible locations utilizing other mathematical tools such as the singular values and the sensitivities. Finally, simulations in the time are carried out to corroborate the results obtained. [Spanish] En este trabajo se presentan tecnicas para la localizacion de dispositivos FACTS (Sistemas Flexibles de Transmision de C.A) en un sistema de potencia multimaquinas a fin de mejorar el comportamiento transitorio electromecanico. En la primera parte se presenta una breve introduccion acerca de los dispositivos FACTS, en la cual se mencionan

Brain Aneurysm Statistics and Facts

Science.gov (United States)

... Statistics and Facts A- A A+ Brain Aneurysm Statistics and Facts An estimated 6 million people in ... Understanding the Brain Warning Signs/ Symptoms Brain Aneurysm Statistics and Facts Seeking Medical Attention Risk Factors Aneurysm ...

Controlled release of biofunctional substances by radiation-induced polymerization

International Nuclear Information System (INIS)

Yoshida, M.; Kumakura, M.; Kaetsu, I.

1978-01-01

The release behaviour of a drug from flat circular capsules obtained by radiation-induced polymerization at low temperatures and with different hydrophilic properties has been studied. The effect of various factors on release property was investigated. The release process could be divided into three parts, an initial quick release stage, stationary state release stage and a retarded release stage. Release behaviour in the stationary state was examined using Noyes-Whitney and Higuchi equations. It was shown that the hydrophilic property of polymer matrix expressed by water content was the most important effect on diffusion and release rate. Rigidity of the polymer may also affect diffusivity. The first quick release step could be attributed to rapid dissolution of drug in the matrix surface due to polymer swelling. (author)

Support for Arts Education. State Arts Agency Fact Sheet

Science.gov (United States)

National Assembly of State Arts Agencies, 2011

2011-01-01

Supporting lifelong learning in the arts is a top priority for state arts agencies. By supporting arts education in the schools, state arts agencies foster young imaginations, address core academic standards, and promote the critical thinking and creativity skills essential to a 21st century work force. State arts agencies also support…

Facts against nuclear electricity generation. 2. enlarged ed.

International Nuclear Information System (INIS)

Buechele, C.

1986-01-01

The book destroys a legend. The nuclear cartel still goes on telling the tale of safety, environmental compatibility and economic efficiency of nuclear electricity generation. But nothing in this story stands the test: Bare facts destroy the legend. Up to now, only insiders have been able to state counterarguments. The book in hand now presents in a nutshell all results and experience and facts to be brought forward against nuclear electricity generation. The material is presented in a problem-oriented, reliable and comprehensible manner. Anyone who long since suspected lies and malinformation of the public will step by step find the arguments justifying his suspicion. In an annex, Harald Gaber explains the Chernobyl disaster and its consequences. A literature index with comments is a helpful guide for further reading. (orig.) [de

Key Facts about Tularemia

Science.gov (United States)

... Submit What's this? Submit Button Key Facts About Tularemia Recommend on Facebook Tweet Share Compartir This fact ... and Prevention (CDC) Tularemia Web site . What is Tularemia? Tularemia is a potentially serious illness that occurs ...

Meningitis Myths and Facts

Science.gov (United States)

... Diseases Infographic Prevention and Control of Meningococcal Disease Meningitis Myths and Facts Myth: Meningococcal disease is easy ... infected person, such as shaking hands. Fact: Meningococcal meningitis is spread through air droplets and direct contact ...

The Accountability Turn in Third Wave Human Rights Fact-Finding

Directory of Open Access Journals (Sweden)

Federica D'Alessandra

2017-04-01

Full Text Available Whereas the characteristics of human rights fact-finding largely vary depending on the typology and scope of the entity that carries it out, consensus seems to be developing that a common set of challenges to human rights fact-finding exists. This is especially so when carried out under United Nations auspices. For example, it has long been acknowledged that the very nature of the institution, sitting as it does at the crossroads of international politics, as well as the seemingly irresolvable tension between calls for human rights protection on the one hand, and State sovereignty on the other, present some structural challenges to human rights fact-finding. Furthermore, issues of coordination between the United Nations and other institutions (such as international governmental and non-governmental organisations, or international tribunals, as well as what some have called a ‘lack of institutional memory’ arguably often feature as regular traits among fact-finding mechanisms. In recent years, a further set of challenges has been added to the mix by additional requirements, featuring increasingly often in mandates, that instruct fact-finding mechanisms to make further determinations of facts (concerning, 'e.g.', the identity of those most responsible for the violations being documented, or the existence of an armed conflict and even consider questions of law ('e.g.' the qualification of the violations as crimes under international law. Building on an expanding body of scholarship on the subject, as well as the author’s own experience with fact-finding efforts sitting at the intersection between traditional international human rights law and international criminal justice, this article argues: (i that human rights fact-finding has evolved in three waves; (ii that the third wave of human rights fact-finding is characterised by an “accountability turn”; and that (iii this turn has brought about an additional set of challenges to the

West Valley Demonstration Project vitrification process equipment Functional and Checkout Testing of Systems (FACTS)

International Nuclear Information System (INIS)

Carl, D.E.; Paul, J.; Foran, J.M.; Brooks, R.

1990-01-01

The Vitrification Facility (VF) at the West Valley Demonstration Project was designed to convert stored radioactive waste into a stable glass for disposal in a federal repository. The Functional and Checkout Testing of Systems (FACTS) program was conducted from 1984 to 1989. During this time new equipment and processes were developed, installed, and implemented. Thirty-seven FACTS tests were conducted, and approximately 150,000 kg of glass were made by using nonradioactive materials to simulate the radioactive waste. By contrast, the planned radioactive operation is expected to produce approximately 500,000 kg of glass. The FACTS program demonstrated the effectiveness of equipment and procedures in the vitrification system, and the ability of the VF to produce quality glass on schedule. FACTS testing also provided data to validate the WVNS waste glass qualification method and verify that the product glass would meet federal repository acceptance requirements. The system was built and performed to standards which would have enabled it to be used in radioactive service. As a result, much of the VF tested, such as the civil construction, feed mixing and holding vessels, and the off-gas scrubber, will be converted for radioactive operation. The melter was still in good condition after being at temperature for fifty-eight of the sixty months of FACTS. However, the melter exceeded its recommended design life and will be replaced with a similar melter. Components that were not designed for remote operation and maintenance will be replaced with remote-use items. The FACTS testing was accomplished with no significant worker injury or environmental releases. During the last FACTS run, the VF processes approximated the remote-handling system that will be used in radioactive operations. Following this run the VF was disassembled for conversion to a radioactive process. Functional and checkout testing of new components will be performed prior to radioactive operation

Cocaine (Coke, Crack) Facts

Science.gov (United States)

... That People Abuse » Cocaine (Coke, Crack) Facts Cocaine (Coke, Crack) Facts Listen Cocaine is a white ... 69 KB) "My life was built around getting cocaine and getting high." ©istock.com/ Marjot Stacey is ...

Chlamydia - CDC Fact Sheet

Science.gov (United States)

... Archive STDs Home Page Bacterial Vaginosis (BV) Chlamydia Gonorrhea Genital Herpes Hepatitis HIV/AIDS & STDs Human Papillomavirus ( ... sheet Pelvic Inflammatory Disease (PID) – CDC fact sheet Gonorrhea – CDC fact sheet STDs Home Page Bacterial Vaginosis ( ...

Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation.

Science.gov (United States)

Uvnäs-Moberg, Kerstin; Handlin, Linda; Petersson, Maria

2014-01-01

Oxytocin, a hypothalamic nonapeptide, is linked to increased levels of social interaction, well-being and anti-stress effects. The effects of oxytocin that is released by sensory stimulation during different kinds of interactive behaviors are often underestimated or even forgotten. In fact, many of the positive effects caused during interaction, such a wellbeing, stress reduction and even health promotion, are indeed linked to oxytocin released in response to activation of various types of sensory nerves. Oxytocin is released in response to activation of sensory nerves during labor, breastfeeding and sexual activity. In addition oxytocin is released in response to low intensity stimulation of the skin, e.g., in response to touch, stroking, warm temperature, etc. Consequently oxytocin is not only released during interaction between mothers and infants, but also during positive interaction between adults or between humans and animals. Finally oxytocin is also released in response to suckling and food intake. Oxytocin released in the brain in response to sensory stimulation as a consequence of these types of interactive behaviors, contributes to every day wellbeing and ability to handle stress. Food intake or sex may be used or even abused to achieve oxytocin-linked wellbeing and stress relief to compensate for lack of good relationships or when the levels of anxiety are high. The present review article will summarize the role played by oxytocin released by sensory (in particular somatosensory) stimulation, during various kinds of interactive behaviors. Also the fact that the anti-stress effects of oxytocin are particularly strong when oxytocin is released in response to "low intensity" stimulation of the skin will be highlighted.

Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

Directory of Open Access Journals (Sweden)

Kerstin eUvnäs-Moberg

2015-01-01

Full Text Available Oxytocin, a hypothalamic nonapeptide, is linked to increased levels of social interaction, well-being and anti-stress effects. The effects of oxytocin that is released by sensory stimulation during different kinds of interactive behaviors are often underestimated or even forgotten. In fact, many of the positive effects caused during interaction, such a wellbeing, stress reduction and even health promotion, are indeed linked to oxytocin released in response to activation of various types of sensory nerves. Oxytocin is released in response to activation of sensory nerves during labor, breastfeeding and sexual activity. In addition oxytocin is released in response to low intensity stimulation of the skin, e.g. in response to touch, stroking, warm temperature etc . Consequently oxytocin is not only released during interaction between mothers and infants, but also during positive interaction between adult or between humans and animals. Finally oxytocin is also released in response to suckling and food intake. Oxytocin released in the brain in response to sensory stimulation as a consequence of these types of interactive behaviors, contributes to every day wellbeing and ability to handle stress. Food intake or sex may be used or even abused to achieve oxytocin-linked wellbeing and stress relief to compensate for lack of good relationships or when the levels of anxiety are high. The present review article will summarize the role played by oxytocin released by sensory (in particular somatosensory stimulation, during various kinds of interactive behaviors. Also the fact that the anti-stress effects of oxytocin are particularly strong when oxytocin is released in response to low intensity stimulation of the skin will be highlighted.

High Blood Pressure Facts

Science.gov (United States)

... Stroke Heart Disease Cholesterol Salt Million Hearts® WISEWOMAN High Blood Pressure Facts Recommend on Facebook Tweet Share Compartir On ... Top of Page CDC Fact Sheets Related to High Blood Pressure High Blood Pressure Pulmonary Hypertension Heart Disease Signs ...

African American Students and U.S. High Schools. Fact Sheet

Science.gov (United States)

Alliance for Excellent Education, 2008

2008-01-01

This fact sheet highlights the statistics of the status of the African American students living in the continental United States in terms of: population; graduation, dropouts, and preparedness; schools, segregation, and teacher quality; and special, gifted, and college preparatory education. According to the National Center for Education…

The Fabulous Fact Fan.

Science.gov (United States)

Couch, Jene P.

1994-01-01

Discusses the use and construction of "fact fans," fun and easy-to-make manipulatives that provide elementary school students with the opportunity to explore mathematics operations being studied in the classroom and to practice addition, subtraction, multiplication, and division facts. (BB)

John Searle on Institutional Facts

Directory of Open Access Journals (Sweden)

m Abdullahi

2010-09-01

Here we argue that the essence of institutional facts is status functions. Humans recognize these functions which contain a set of deontic powers through collective intentionality. Therefore, institutional facts are ontologically subjective and epistemologically objective. Nevertheless, objectivity of institutional facts totally depends on language which itself is a fundamental institution for other institutions.

Contact: Releasing the news

Science.gov (United States)

Pinotti, Roberto

The problem of mass behavior after man's future contacts with other intelligences in the universe is not only a challenge for social scientists and political leaders all over the world, but also a cultural time bomb as well. In fact, since the impact of CETI (Contact with Extraterrestrial Intelligence) on human civilization, with its different cultures, might cause a serious socio-anthropological shock, a common and predetermined worldwide strategy is necessary in releasing the news after the contact, in order to keep possible manifestations of fear, panic and hysteria under control. An analysis of past studies in this field and of parallel historical situations as analogs suggests a definite "authority crisis" in the public as a direct consequence of an unexpected release of the news, involving a devastating "chain reaction" process (from both the psychological and sociological viewpoints) of anomie and maybe the collapse of today's society. The only way to prevent all this is to prepare the world's public opinion concerning contact before releasing the news, and to develop a long-term strategy through the combined efforts of scientists, political leaders, intelligence agencies and the mass media, in order to create the cultural conditions in which a confrontation with ETI won't affect mankind in a traumatic way. Definite roles and tasks in this multi-level model are suggested.

Catalog of CERCLA applicable or relevant and appropriate requirements (ARARs) - fact sheets

Energy Technology Data Exchange (ETDEWEB)

1990-07-01

Section 121(d) of the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), requires attainment of federal and state applicable or relevant and appropriate requirements (ARARs). Subpart E, Section 300.400(g) {open_quotes}Identification of applicable or relevant and appropriate requirements{close_quotes} of the National Oil and Hazardous Substances Pollution Contingency Plan (NCP)(55 FR 8666, March 8, 1990) describes the process for attaining ARARs. The purpose of this catalog is to provide DOE Program Offices and Field Organizations with all of the {open_quotes}Quick Reference Fact Sheets{close_quotes} on attaining ARARS. These fact sheets provide overviews of ARARs for CERCLA cleanup actions pertinent to DOE environmental restoration activities. All of the fact sheets in this catalog were prepared by the Environmental Protection Agency`s Office of Solid Waste and Emergency Response. Fact sheets 1-7 discuss land disposal restrictions (LDRs) and their applicability. LDRs may pertain to a number of CERCLA response actions at DOE facilities. Fact Sheets 8-13 are based on the CERCLA Compliance with Other Laws Manual: Parts I and II and provide an overview of many other CERCLA ARARs. Overview of ARARs-Focus on ARAR Waivers (fact sheet 11), provides a good introduction to ARARS. The last two fact sheets, 14 and 15, are periodic reports that describe additional fact sheets and clarify issues.

Framework for DOE mixed low-level waste disposal: Site fact sheets

Energy Technology Data Exchange (ETDEWEB)

Gruebel, M.M.; Waters, R.D.; Hospelhorn, M.B.; Chu, M.S.Y. [eds.

1994-11-01

The Department of Energy (DOE) is required to prepare and submit Site Treatment Plans (STPS) pursuant to the Federal Facility Compliance Act (FFCAct). Although the FFCAct does not require that disposal be addressed in the STPS, the DOE and the States recognize that treatment of mixed low-level waste will result in residues that will require disposal in either low-level waste or mixed low-level waste disposal facilities. As a result, the DOE is working with the States to define and develop a process for evaluating disposal-site suitability in concert with the FFCAct and development of the STPS. Forty-nine potential disposal sites were screened; preliminary screening criteria reduced the number of sites for consideration to twenty-six. The DOE then prepared fact sheets for the remaining sites. These fact sheets provided additional site-specific information for understanding the strengths and weaknesses of the twenty-six sites as potential disposal sites. The information also provided the basis for discussion among affected States and the DOE in recommending sites for more detailed evaluation.

Building an Efficient Model for Afterburn Energy Release

Energy Technology Data Exchange (ETDEWEB)

Alves, S; Kuhl, A; Najjar, F; Tringe, J; McMichael, L; Glascoe, L

2012-02-03

Many explosives will release additional energy after detonation as the detonation products mix with the ambient environment. This additional energy release, referred to as afterburn, is due to combustion of undetonated fuel with ambient oxygen. While the detonation energy release occurs on a time scale of microseconds, the afterburn energy release occurs on a time scale of milliseconds with a potentially varying energy release rate depending upon the local temperature and pressure. This afterburn energy release is not accounted for in typical equations of state, such as the Jones-Wilkins-Lee (JWL) model, used for modeling the detonation of explosives. Here we construct a straightforward and efficient approach, based on experiments and theory, to account for this additional energy release in a way that is tractable for large finite element fluid-structure problems. Barometric calorimeter experiments have been executed in both nitrogen and air environments to investigate the characteristics of afterburn for C-4 and other materials. These tests, which provide pressure time histories, along with theoretical and analytical solutions provide an engineering basis for modeling afterburn with numerical hydrocodes. It is toward this end that we have constructed a modified JWL equation of state to account for afterburn effects on the response of structures to blast. The modified equation of state includes a two phase afterburn energy release to represent variations in the energy release rate and an afterburn energy cutoff to account for partial reaction of the undetonated fuel.

Nickel release from earrings purchased in the united states: the San Francisco earring study

DEFF Research Database (Denmark)

Maibach, H.I.; Thyssen, Jacob Pontoppidan

2008-01-01

Background: Nickel sensitization is frequent among US patients with dermatitis and in the general population. In Europe, decreasing prevalences of nickel sensitization are observed as a result of the European Union Nickel Directive. However, no directive exists in the United States. Objectives: We...... sought to examine nickel release from inexpensive earrings and discuss possible methods of reducing nickel exposure among consumers. Methods: A total of 34 different stores and artists were visited. A total of 277 earrings were purchased and examined with the dimethylglyoxitne (DMG) test. Results: DMG......-positive earrings were identified from local artists (69%) and tourist stores (42.9%) but also chain stores targeting young (24.1%) and mature (1.7%) women. No correlation between price and outcome of DMG testing was identified. Limitations. Our study does not reflect buying trends in the United States...

27 CFR 40.452 - Release from customs custody.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Release from customs... § 40.452 Release from customs custody. Cigarette papers and tubes which were made in the United States, exported, and subsequently returned to the United States, may be removed from customs custody for transfer...

The influence of spray-drying parameters on phase behavior, drug distribution, and in vitro release of injectable microspheres for sustained release.

Science.gov (United States)

Meeus, Joke; Lenaerts, Maité; Scurr, David J; Amssoms, Katie; Davies, Martyn C; Roberts, Clive J; Van Den Mooter, Guy

2015-04-01

For ternary solid dispersions, it is indispensable to characterize their structure, phase behavior, and the spatial distribution of the dispersed drug as this might influence the release profile and/or stability of these formulations. This study shows how formulation (feed concentration) and process (feed rate, inlet air temperature, and atomizing air pressure) parameters can influence the characteristics of ternary spray-dried solid dispersions. The microspheres considered here consist of a poly(lactic-co-glycolic acid) (PLGA) surface layer and an underlying polyvinylpyrrolidone (PVP) phase. A poorly soluble active pharmaceutical ingredient (API) was molecularly dispersed in this matrix. Differences were observed in component miscibility, phase heterogeneity, particle size, morphology, as well as API surface coverage for selected spray-drying parameters. Observed differences are likely because of changes in the droplet generation, evaporation, and thus particle formation processes. However, varying particle characteristics did not influence the drug release of the formulations studied, indicating the robustness of this approach to produce particles of consistent drug release characteristics. This is likely because of the fact that the release is dominated by diffusion from the PVP layer through pores in the PLGA surface layer and that observed differences in the latter have no influence on the release. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

Vitamin and Mineral Supplement Fact Sheets

Science.gov (United States)

... website Submit Search NIH Office of Dietary Supplements Vitamin and Mineral Supplement Fact Sheets Search the list ... Supplements: Background Information Botanical Dietary Supplements: Background Information Vitamin and Mineral Fact Sheets Botanical Supplement Fact Sheets ...

Investigation of delayed fission gas release

International Nuclear Information System (INIS)

Cayet, Nicolas

1996-05-01

The study of the fission gas release process in the high burnup rig IFA-562 has revealed a particular fuel behaviour: a delay in the fission gas release process. It appeared that an important release of gas was measured by the pressure transducers once the power had decreased, whereas, during steady-state operation, the pressure did not increase very much. After examinations, the gap size has been concluded to be the main parameter involving this delay. However the burnup could have been a potential factor, its role is mainly to close the gap by swelling. The observations of low burnup rods have shown the same delayed fission gas release, the gap being small by design and closed essentially by thermal expansion. The study of the kinetics has demonstrated the time-independency of the phenomenon. Thus the proposed mechanism driving this delayed fission gas release would involve three consecutives stages. During steady-state, the gas is released into the interlinkage network of grain boundary bubbles and cracks. Due to the closed gap, the gas is trapped in some void volumes, unable to escape the pellet. During power reduction, the gap and some old/new cracks open, immediately providing a path for the gas to the pressure transducers and explaining this delay in the fission gas release. (author)

Five Indisputable Facts on Modern Power Systems

Energy Technology Data Exchange (ETDEWEB)

Bloom, Aaron P [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Brinkman, Gregory L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Lopez, Anthony J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Holttinen, Hannele [VTT Technical Research Centre of Finland; Helman, Udi [Helman Analytics; Summers, Kate [Pacific Hydro; Bakke, Jordan [Midcontinent Independent System Operator

2017-08-01

This presentation overviews five indisputable facts about modern power systems: Fact one: The grid can handle more renewable generation than previously thought. Fact two: Geographic and resource diversity provide additional reliability to the system. Fact three: Wind and solar forecasting provide significant value. Fact four: Our electric power markets were not originally designed for variable renewables -- but they could be adapted. Fact five: Modern power electronics are creating new sources of essential reliability services.

Evaluation of PCB sources and releases for identifying priorities to reduce PCBs in Washington State (USA).

Science.gov (United States)

Davies, Holly; Delistraty, Damon

2016-02-01

Polychlorinated biphenyls (PCBs) are ubiquitously distributed in the environment and produce multiple adverse effects in humans and wildlife. As a result, the purpose of our study was to characterize PCB sources in anthropogenic materials and releases to the environment in Washington State (USA) in order to formulate recommendations to reduce PCB exposures. Methods included review of relevant publications (e.g., open literature, industry studies and reports, federal and state government databases), scaling of PCB sources from national or county estimates to state estimates, and communication with industry associations and private and public utilities. Recognizing high associated uncertainty due to incomplete data, we strived to provide central tendency estimates for PCB sources. In terms of mass (high to low), PCB sources include lamp ballasts, caulk, small capacitors, large capacitors, and transformers. For perspective, these sources (200,000-500,000 kg) overwhelm PCBs estimated to reside in the Puget Sound ecosystem (1500 kg). Annual releases of PCBs to the environment (high to low) are attributed to lamp ballasts (400-1500 kg), inadvertent generation by industrial processes (900 kg), caulk (160 kg), small capacitors (3-150 kg), large capacitors (10-80 kg), pigments and dyes (0.02-31 kg), and transformers (PCB distribution and decrease exposures include assessment of PCBs in buildings (e.g., schools) and replacement of these materials, development of Best Management Practices (BMPs) to contain PCBs, reduction of inadvertent generation of PCBs in consumer products, expansion of environmental monitoring and public education, and research to identify specific PCB congener profiles in human tissues.

Are we reaching the target audience? Evaluation of a fish fact sheet.

Science.gov (United States)

Burger, J; Waishwell, L

2001-09-28

According to the US Environmental Protection Agency, over 16% of freshwater lakes and 7% of the rivers are under some sort of fish consumption advisory because of the presence of toxic chemicals. There is considerable interest in the issuing of information, advisories, and fact sheets concerning the consumption of wild-caught fish from contaminated waters, and in the actual consumption patterns of subsistence and recreational anglers. Despite the large number of consumption advisories issued by state agencies, there is little information on how these advisories, or other forms of risk communication, are perceived by target audiences, notably fishermen and women of child-bearing age. The states of South Carolina and Georgia issue consumption advisories for fish from the Savannah River, among other sites. To gain a greater insight into the perception of anglers about a supplemental fish fact sheet jointly developed by South Carolina, Georgia, federal agencies, and the Consortium for Risk Evaluation with Stakeholder Participation, we interviewed fisherman along the Savannah River. The objectives were to determine: (1) whether they had previously read the Fish Fact Sheet or had heard about the consumption advisories; (2) what major message they obtained from the sheet; (3) who they felt the fact sheet was aimed at, and who should get the Fish Fact Sheet; (4) who should be concerned about health risks from consuming the fish; and (5) the best method of disseminating such information. We interviewed 92 fishermen (37% black, 62% white) during the fishing season of 1999. Half had heard some information about consumption advisories, mainly from the media (64%). The study concluded that there were no ethnic differences in whether they had heard about the advisories, understood the major message of the fact sheet, felt they could reduce their risk from consuming the fish, or felt that it made a difference which agency issued the fact sheet. There were significant ethnic

Asthma and Environment Fact Sheet for Parents and Schools. Revised

Science.gov (United States)

Healthy Schools Network, Inc., 2012

2012-01-01

Important facts about asthma and the environment include: (1) Asthma has reached epidemic proportions in the United States, affecting about 25 million people of all ages and races, including about 7 million children; (2) Nearly one in 10 school-aged children has asthma, and the percentage of children with asthma is rising more rapidly in…

Drug Facts

Medline Plus

Full Text Available ... Nicotine Facts Other Drugs of Abuse What is Addiction? What are some signs and symptoms of someone ... use problem? How Does Drug Use Become an Addiction? What Makes Someone More Likely to Get Addicted ...

Evaluating bioremediation: distinguishing fact from fiction.

Science.gov (United States)

Shannon, M J; Unterman, R

1993-01-01

Bioremediation options encompass diverse types of biochemical mechanisms that may lead to a target's mineralization, partial transformation, humification, or altered redox state (e.g. for metallic elements). Because these various mechanisms produce alternative fates of the targeted pollutants, it is often necessary to use diverse evaluation criteria to qualify a successful bioremediation. Too often target depletion from a treated matrix can be mistakenly ascribed to biological activity when in fact the depletion is caused by abiotic losses (e.g. volatilization, leaching, and stripping). Thus, effective, and therefore convincing, evaluation requires that experimental and engineering designs anticipate all possible routes of target depletion and that these routes be carefully monitored.

Fact Sheet - Final Air Toxics Rule for Gold Mine Ore Processing and Production

Science.gov (United States)

Fact sheet summarizing main points of National Emissions Standards for Hazardous Air Pollutants for gold ore processing and production facilities, the seventh largest source of mercury air emission in the United States.

Measurements of the Shock Release Of Quartz and Paralyene-N

Science.gov (United States)

Hawreliak, James; Karasik, Max; Oh, Jaechul; Aglitskiy, Yefim

2017-06-01

The shock and release properties of Quartz and hydrocarbons are important to high energy density (HED) research and inertial confinement fusion (ICF) science. The bulk of HED material research studies single shock or multiple shock conditions. The challenge with measuring release properties is unlike shocks which have a single interface from which to measure the properties, the release establishes gradients in the sample. The streaked x-ray imaging capability of the NIKE laser allow the interface between quartz and CH to be measured during the release, giving measurements of the interface velocity and CH density. Here, we present experimental results from the NIKE laser where quartz and parylene-N are shock compressed to high pressure and temperature and the release state is measured through x-ray imaging. The shock state is characterized by shock front velocity measurements using VISAR and the release state is characterized by using side-on streaked x-ray radiography Work supported by DOE/NNSA.

Heat release rate of wood-plastic composites

Science.gov (United States)

N. M. Stark; R. H. White; C. M. Clemons

1997-01-01

Wood-plastic composites are becoming more important as a material that fulfills recycling needs. In this study, fire performance tests were conducted on several compositions of wood and plastic materials using the Ohio State University rate of heat release apparatus. Test results included five-minute average heat release rate in kW/m2 (HRR avg) and maximum heat release...

Facts about Anophthalmia and Microphthalmia

Science.gov (United States)

... Facts About Anophthalmia and Microphthalmia Listen Facts About Anophthalmia and Microphthalmia This information was developed by the ... is the best person to answer specific questions. Anophthalmia and Microphthalmia Defined What are anophthalmia and microphthalmia? ...

Activation and regulation of arachidonic acid release in rabbit peritoneal neutrophils

International Nuclear Information System (INIS)

Tao, W.

1988-01-01

Arachidonic acid release in rabbit neutrophils can be enhanced by the addition of chemotactic fMet-Leu-Phe, platelet-activating factor, PAF, or the calcium ionophore A23187. Over 80% of the release [ 3 H]arachidonic acid comes from phosphatidylcholine and phosphatidylinositol. The release is dose-dependent and increases with increasing concentration of the stimulus. The A23187-induced release increases with increasing time of the stimulation. [ 3 H]arachidonic acid release, but not the rise in the concentration of intracellular calcium, is inhibited in pertussis toxin-treated neutrophils stimulated with PAF. The [ 3 H]arachidonic acid released by A23187 is potentiated while that release by fMET-Leu-Phe or PAF is inhibited in phorbol 12-myristate 13-acetate, PMA, treated rabbit neutrophils. The protein kinase C inhibitor 1-(5-isoquinoline sulfonyl)-2-methylpiperazine, H-7, has no effect on the potentiation by PMA of the A23187-induced release, it prevents the inhibition by PMA of the release produced by PAF or fMet-Leu-Phe. In addition, PMA increases arachidonic acid release in H-7-treated cells stimulated with fMet-Leu-Phe. The diacylglycerol kinase inhibitor R59022 increases the level of diacylglycerol in neutrophils stimulated with fMet-Leu-Phe. Furthermore, R59022 potentiates [ 3 H] arachidonic acid release produced by fMet-Leu-Phe. This potentiation is not inhibited by H-7, in fact, it is increased in H-7-treated neutrophils

Field Audit Checklist Tool (FACT)

Science.gov (United States)

Download EPA's The Field Audit Checklist Tool (FACT). FACT is intended to help auditors perform field audits, to easily view monitoring plan, quality assurance and emissions data and provides access to data collected under MATS.

Vehicle Technologies’ Fact of the Week 2013

Energy Technology Data Exchange (ETDEWEB)

Davis, Stacy Cagle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Diegel, Susan W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Moore, Sheila A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boundy, Robert Gary [Roltek, Inc., Clinton, TN (United States)

2014-04-01

Each week the U.S. Department of Energy’s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week’s Fact is available on the VTO homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2013. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

Vehicle Technologies Fact of the Week 2013

Energy Technology Data Exchange (ETDEWEB)

Davis, Stacy Cagle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Susan E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Moore, Sheila A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boundy, Robert Gary [Roltek, Inc., Clinton, TN (United States)

2014-03-01

Each week the U.S. Department of Energy s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week s Fact is available on the VTO homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2013. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

A comparison of the extended-release and standard-release formulations of tacrolimus in de novo kidney transplant recipients: a 12-month outcome study.

Science.gov (United States)

Fanous, Helen; Zheng, Rebecca; Campbell, Carolyn; Huang, Michael; Nash, Michelle M; Rapi, Lindita; Zaltzman, Jeffrey S; Prasad, G V Ramesh

2013-02-01

BACKGROUND: Limited comparative data are available on the outcomes between extended-release and standard-release tacrolimus when used de novo in kidney transplant recipients (KTRs). METHODS: We identified KTRs transplanted at our institution during 2009-10 routinely prescribed extended-release tacrolimus and compared them with those transplanted during 2008-09 prescribed standard-release tacrolimus. Graft function (eGFR by MDRD-7 equation) at 12 months post-transplant (primary outcome); new-onset diabetes and other cardiovascular risk factors, BK viremia incidence, acute rejection, and graft survival to 12 months (secondary outcomes) were compared by intent-to-treat analysis. Time-to-steady-state concentration and number of dose adjustments required to attain steady state were recorded. RESULTS: There were no important demographic differences between the extended-release (N = 106) and standard-release (N = 95) cohorts. The estimated glomerular filtration rate (eGFR) at 12 months was similar (58.8 ± 17 versus 59.2 ± 18 mL/min/1.73 m(2), P = 0.307). There was no difference in new-onset diabetes (17 versus 20%, P = 0.581), BK viremia (10 versus 7%, P = 0.450), acute rejection (7 versus 16%, P = 0.067) or graft survival (97 versus 95%, P = 0.301). Time-to-steady state was similar (9.2 ± 1.1 versus 8.1 ± 4.7 days, P = 0.490) although extended-release patients required fewer adjustments to attain steady state (1.2 ± 1.7 [0-8] versus 1.7 ± 1.5 [0-7], P = 0.030) but a similar dose (7.2 ± 2.4 [2-17] versus 7 ± 2.7 [2-16] mg/day, P = 0.697). CONCLUSION: De novo KTRs prescribed extended-release or standard-release tacrolimus demonstrate similar 12-month outcomes.

Vehicle Technologies Fact of the Week 2015

Energy Technology Data Exchange (ETDEWEB)

Davis, Stacy C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Diegel, Susan W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Moore, Sheila A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boundy, Robert G. [Roltek, Inc., Clinton, TN (United States)

2016-05-01

Each week the U.S. Department of Energy s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week s Fact is available on the VTO homepage, but older Facts (back to 2009) are archived and still available at: http://energy.gov/eere/vehicles/current-and-past-years-facts-week. Each Fact of the Week website page includes a link to an Excel file. That file contains the data from the Supporting Information section of the page so that researchers can easily use data from the Fact of the Week in their work. Beginning in August of 2015, a subscription list is available on the DOE website so that those interested can sign up for an email to be sent each Monday which includes the text and graphic from the current week s Fact. This report is a compilation of the Facts that were posted during calendar year 2015. The Facts were created, written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

Effects of Higher-order Cognitive Strategy Training on Gist Reasoning and Fact Learning in Adolescents

Directory of Open Access Journals (Sweden)

Jacquelyn F Gamino

2010-12-01

Full Text Available Improving the reasoning skills of adolescents across the United States has become a major concern for educators and scientists who are dedicated to identifying evidence-based protocols to improve student outcome. This small sample randomized, control pilot study sought to determine the efficacy of higher-order cognitive training on gist-reasoning and fact-learning in an inner-city public middle school. The study compared gist-reasoning and fact-learning performances after training in a smaller sample when tested in Spanish, many of the students’ native language, versus English. The 54 eighth grade students who participated in this pilot study were enrolled in an urban middle school, predominantly from lower socio-economic status families, and were primarily of minority descent. The students were randomized into one of three groups, one that learned cognitive strategies promoting abstraction of meaning, a group that learned rote memory strategies, or a control group to ascertain the impact of each program on gist-reasoning and fact-learning from text-based information. We found that the students who had cognitive strategy instruction that entailed abstraction of meaning significantly improved their gist-reasoning and fact-learning ability. The students who learned rote memory strategies significantly improved their fact-learning scores from a text but not gist-reasoning ability. The control group showed no significant change in either gist-reasoning or fact-learning ability. A trend toward significant improvement in overall reading scores for the group that learned to abstract meaning as well as a significant correlation between gist-reasoning ability and the critical thinking on a state-mandated standardized reading test was also found. There were no significant differences between English and Spanish performance of gist reasoning and fact learning. Our findings suggest that teaching higher-order cognitive strategies facilitates gist

Rubella - Fact Sheet for Parents

Science.gov (United States)

... and 4 through 6 years Fact Sheet for Parents Color [2 pages] Español: Rubéola The best way ... according to the recommended schedule. Fact Sheets for Parents Diseases and the Vaccines that Prevent Them Chickenpox ...

27 CFR 27.185 - Customs release.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Customs release. 27.185... Distilled Spirits From Customs Custody Free of Tax for Use of the United States § 27.185 Customs release. (a) Upon receipt of appropriate customs entry and a photocopy of a permit, Form 5150.33 or previous...

Sustainable Materials Management (SMM) - Materials and Waste Management in the United States Key Facts and Figures

Data.gov (United States)

U.S. Environmental Protection Agency — Each year EPA produces a report called Advancing Sustainable Materials Management: Facts and Figures. It includes information on municipal solid waste (MSW)...

Development NGOs: Basic Facts

OpenAIRE

Aldashev, Gani; Navarra, Cecilia

2017-01-01

This paper systematizes the results of the empirical literature on development non-governmental organizations (NGOs), drawing both from quantitative and qualitative analyses, and constructs a set of basic facts about these organizations. These basic facts concern the size of the development NGO sector and its evolution, the funding of NGOs, the allocation of NGO aid and projects across beneficiary countries, the relationship of NGOs with beneficiaries, and the phenomenon of globalization of d...

Reptile Facts.

Science.gov (United States)

Steinheimer, Margaret

1993-01-01

Describes an award-winning bulletin board for introducing a unit on reptiles. This interactive bulletin board contains fun facts and counters common misconceptions about reptiles. Twelve true-false statements are hidden behind pull-up flaps. Four pictures ask students to identify the difference between often-confused animals. (PR)

Is Natural Language a Perigraphic Process? The Theorem about Facts and Words Revisited

Directory of Open Access Journals (Sweden)

Łukasz Dębowski

2018-01-01

Full Text Available As we discuss, a stationary stochastic process is nonergodic when a random persistent topic can be detected in the infinite random text sampled from the process, whereas we call the process strongly nonergodic when an infinite sequence of independent random bits, called probabilistic facts, is needed to describe this topic completely. Replacing probabilistic facts with an algorithmically random sequence of bits, called algorithmic facts, we adapt this property back to ergodic processes. Subsequently, we call a process perigraphic if the number of algorithmic facts which can be inferred from a finite text sampled from the process grows like a power of the text length. We present a simple example of such a process. Moreover, we demonstrate an assertion which we call the theorem about facts and words. This proposition states that the number of probabilistic or algorithmic facts which can be inferred from a text drawn from a process must be roughly smaller than the number of distinct word-like strings detected in this text by means of the Prediction by Partial Matching (PPM compression algorithm. We also observe that the number of the word-like strings for a sample of plays by Shakespeare follows an empirical stepwise power law, in a stark contrast to Markov processes. Hence, we suppose that natural language considered as a process is not only non-Markov but also perigraphic.

[Suicide, a social fact].

Science.gov (United States)

Baudelot, Christian

2017-04-01

Treating suicide as a social fact means disregarding its individual and dramatic dimensions. Sociologists do not reason on the basis of specific cases but by studying the variations, in space and time, of suicide rates. Their contribution relates essentially to a renewed perspective on society: suicide is in fact a very accurate indicator of the intensity and quality of the bonds which unite or isolate individuals in a society. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Response to a radioactive materials release having a transboundary impact

International Nuclear Information System (INIS)

1989-01-01

Compared with an accidental release of radioactive material which is confined to the accident State, a transboundary release has added dimensions which were not fully anticipated in publications dealing with response to accidents at nuclear facilities. The new aspects to the problem may be summarized as follows: (1) A transboundary release of radioactive material, as distinct from a release which affects only the accident State, has international repercussions in the following ways: Potentially at least, the difficulties associated with a transboundary release may be magnified in those States that have no nuclear facilities of their own and may, therefore, have foreseen no need for resources to assess and deal with radioactive contamination of their food supplies, their water and their environment appropriately. International trade, in food commodities particularly, may be severely affected. Issues of compensation may arise for which the dispute settlement mechanisms are weak or non-existent. (2) Many Member States are in such geographic locations that they could be affected by a transboundary release occurring in any of their surrounding neighbour States. Planning for and responding to such an event is necessarily more difficult than planning for an accidental release from a single, identified nuclear facility. (3) Deposits of radioactive material from a distant source are apt to be highly unpredictable. Depending on weather conditions, they may be localized in a random fashion or widespread. Because of the international dimension of the problem and its essentially unpredictable character it is recommended here that planning for such events should be carried at the national or federal government level rather than at provincial government level. 14 refs

International Nuclear Fuel Cycle Fact Book. Revision 5

International Nuclear Information System (INIS)

Harmon, K.M.; Lakey, L.T.; Leigh, I.W.; Jeffs, A.G.

1985-01-01

This Fact Book has been compiled in an effort to provide: (1) an overview of worldwide nuclear power and fuel cycle programs; and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries - a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate

International Nuclear Fuel Cycle Fact Book. Revision 5

Energy Technology Data Exchange (ETDEWEB)

Harmon, K.M.; Lakey, L.T.; Leigh, I.W.; Jeffs, A.G.

1985-01-01

This Fact Book has been compiled in an effort to provide: (1) an overview of worldwide nuclear power and fuel cycle programs; and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries - a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate.

International nuclear fuel cycle fact book. Revision 4

Energy Technology Data Exchange (ETDEWEB)

Harmon, K.M.; Lakey, L.T.; Leigh, I.W.

1984-03-01

This Fact Book has been compiled in an effort to provide (1) an overview of worldwide nuclear power and fuel cycle programs and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries - a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids - international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate.

International nuclear fuel cycle fact book. Revision 4

International Nuclear Information System (INIS)

Harmon, K.M.; Lakey, L.T.; Leigh, I.W.

1984-03-01

This Fact Book has been compiled in an effort to provide (1) an overview of worldwide nuclear power and fuel cycle programs and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries - a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids - international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate

Matrix Mathematics Theory, Facts, and Formulas (Second Edition)

CERN Document Server

Bernstein, Dennis S

2011-01-01

When first published in 2005, Matrix Mathematics quickly became the essential reference book for users of matrices in all branches of engineering, science, and applied mathematics. In this fully updated and expanded edition, the author brings together the latest results on matrix theory to make this the most complete, current, and easy-to-use book on matrices. Each chapter describes relevant background theory followed by specialized results. Hundreds of identities, inequalities, and matrix facts are stated clearly and rigorously with cross references, citations to the literature, and illuminat

Dexamethasone-induced haptoglobin release by calf liver parenchymal cells.

Science.gov (United States)

Higuchi, H; Katoh, N; Miyamoto, T; Uchida, E; Yuasa, A; Takahashi, K

1994-08-01

Parenchymal cells were isolated from the liver of male calves, and monolayer cultures formed were treated with glucocorticoids to examine whether haptoglobin, appearance of which is associated with hepatic lipidosis (fatty liver) in cattle, is induced by steroid hormones. Without addition of dexamethasone, only trace amounts of haptoglobin were detected in culture medium. With addition of dexamethasone (10(-12) to 10(-4) M), considerable amounts of haptoglobin were released into the medium. Maximal release was observed at concentrations of 10(-8) to 10(-6) M dexamethasone. Haptoglobin release was similarly induced by cortisol, although the effect was less potent than that of dexamethasone. Actinomycin D (a known protein synthesis inhibitor) dose-dependently reduced amounts of haptoglobin released in response to 10(-8) M dexamethasone. Dexamethasone also induced annexin I, which is known to be synthesized in response to glucocorticoids. Dexamethasone treatment resulted in reduced protein kinase C activity in the cell cytosol, which has been shown to be an early event in dexamethasone-treated cells. Other than glucocorticoids, estradiol induced haptoglobin release, whereas progesterone was less effective. The association of haptoglobin with hepatic lipidosis can be reasonably explained by the fact that haptoglobin production by the liver is induced by glucocorticoids and estradiol, and these steroid hormones are triggers for development of hepatic lipidosis in cattle.

Fabrication of drug eluting implants: study of drug release mechanism from titanium dioxide nanotubes

International Nuclear Information System (INIS)

Hamlekhan, Azhang; Shokuhfar, Tolou; Sinha-Ray, Suman; Yarin, Alexander L; Takoudis, Christos; Mathew, Mathew T; Sukotjo, Cortino

2015-01-01

Formation of titanium dioxide nanotubes (TNTs) on a titanium surface holds great potential for promoting desirable cellular response. However, prolongation of drug release from these nano-reservoirs remains to be a challenge. In our previous work TNTs were successfully loaded with a drug. In this study the effect of TNTs dimensions on prolongation of drug release is quantified aiming at the introduction of a simple novel technique which overcomes complications of previously introduced methods. Different groups of TNTs with different lengths and diameters are fabricated. Samples are loaded with a model drug and rate of drug release over time is monitored. The relation of the drug release rate to the TNT dimensions (diameter, length, aspect ratio and volume) is established. The results show that an increase in any of these parameters increases the duration of the release process. However, the strongest parameter affecting the drug release is the aspect ratio. In fact, TNTs with higher aspect ratios release drug slower. It is revealed that drug release from TNT is a diffusion-limited process. Assuming that diffusion of drug in (Phosphate-Buffered Saline) PBS follows one-dimensional Fick’s law, the theoretical predictions for drug release profile is compatible with our experimental data for release from a single TNT. (paper)

Math Fact Strategies Research Project

Science.gov (United States)

Boso, Annie

2011-01-01

An action research project was conducted in order to determine effective math fact strategies for first graders. The traditional way of teaching math facts included using timed tests and flashcards, with most students counting on their fingers or a number line. Six new research-based strategies were taught and analyzed to decide which methods…

Confusing the drug facts on one nonprescription drug label with those on another: The Drug Facts Label as a text schema

Directory of Open Access Journals (Sweden)

Michael P Ryan

2016-04-01

Full Text Available The Drug Facts Label is designed to guide consumers in comparing nonprescription drugs. Undergraduates studied and recalled drug facts for three analgesic or non-analgesic labels using Drug Facts Label headings as retrieval cues. They then studied and recalled drug facts from an aspirin label. Aspirin recall was greater when the prior labels were analgesics, but prior-label intrusion errors were also greater. These two effects were associated with the number of prior drug labels on which facilitating and interfering drug facts appeared. Using the Drug Facts Label schema to read drug labels can both enhance and degrade the recall of nonprescription drug facts.

Disestablishing Sex: The Case for Released-Time Sex Education

Science.gov (United States)

Glanzer, Perry L.

2011-01-01

Allowing nonschool organizations to provide sex education in a released-time format would disestablish state-funded sex education and give families a choice in the sex education that would be provided for their children. Released-time programs, as originally conceived and currently practiced, allow students to be released for a period of time…

CMS Fast Facts

Data.gov (United States)

U.S. Department of Health & Human Services — CMS has developed a new quick reference statistical summary on annual CMS program and financial data. CMS Fast Facts includes summary information on total program...

Some basic facts about radioactive radon

International Nuclear Information System (INIS)

Duval, J.S.; Tanner, A.B.

1990-01-01

This article presents some basic facts about 222 Rn. These facts include: half-life; diffusion patterns; how radon enters a house; health risks; and means of definition and estimation of radon hazard potential

Vehicle Technologies' Fact of the Week 2012

Energy Technology Data Exchange (ETDEWEB)

Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Moore, Sheila A [ORNL; Boundy, Robert Gary [ORNL

2013-02-01

Each week the U.S. Department of Energy s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week s Fact is available on the VTO homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2012. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

Vehicle Technologies' Fact of the Week 2011

Energy Technology Data Exchange (ETDEWEB)

Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

2012-04-01

Each week the U.S. Department of Energy s Vehicle Technology Program (VTP) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/. These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current Fact is available Monday through Friday on the VTP homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2011. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

Postpartum Depression Facts

Science.gov (United States)

... Where can I find more information? Share Postpartum Depression Facts Download PDF Download ePub Download Mobi Order ... for herself or her family. What is postpartum depression? Postpartum depression is a mood disorder that can ...

Snapple[R] Real Facts Watercolors

Science.gov (United States)

Hodge, Stephanie

2007-01-01

Did you know that a hummingbird weighs less than a penny? Or that an elephant swims twenty miles a day? These are just two of the many facts that Snapple prints on the lids of their drink bottles. When Snapple first introduced the Snapple Real Facts the author was excited to see that something so trivial was also educational. She asked herself if…

Atmospheric release advisory capability pilot project at two nuclear power plants and associated state offices of emergency preparedness. Final report

International Nuclear Information System (INIS)

Rosen, L.C.

1983-01-01

A project to demonstrate the feasibility of utilizing Atmospheric Release Advisory Capability (ARAC) limited service with commercial nuclear power plants and their associated state offices of emergency preparedness is discussed. Preliminary planning, installation and testing of the ARAC site facilities at Indian Point Nucler Power Station, New York State; at New York State Office of Emergency Preparedness, Albany, New York; at Rancho Seco Nuclear Generating Station, California; and at the State of California Office of Emergency Services, Sacramento, California, are summarized. ARAC participation in the Robert E. Ginna nuclear generating plant accident in New York on January 25, 1982, is discussed. The ARAC system is evaluated with emphasis on communications, the suite of models contained within the ARAC system, and the staff. The implications of this project in designing the next-generation ARAC system to service federal and state needs are assessed

Anesthesia Fact Sheet

Science.gov (United States)

... Education About NIGMS NIGMS Home > Science Education > Anesthesia Anesthesia Tagline (Optional) Middle/Main Content Area En español ... Version (464 KB) Other Fact Sheets What is anesthesia? Anesthesia is a medical treatment that prevents patients ...

Facts about Omphalocele

Science.gov (United States)

... label> Information For… Media Policy Makers Facts about Omphalocele Language: English (US) Español (Spanish) Recommend on Facebook ... hardly ever is open or broken. What is Omphalocele? Omphalocele, also known as exomphalos, is a birth ...

Opening the Door to the American Dream: Increasing Higher Education Access and Success for Immigrants. New York Fact Sheet

Science.gov (United States)

Erisman, Wendy; Looney, Shannon

2008-01-01

This fact sheet presents a snapshot of important facts that are specific to the state of New York from the "Opening the Door to the American Dream: Increasing Higher Education Access and Success for Immigrants" report, which exposes systemic barriers that prevent immigrants from entering college and/or completing bachelor's degrees…

Facts and Figures

Science.gov (United States)

... Saves Lives Facts & Figures My Blood, Your Blood Blood Donation Types Did you know there is more than one type of blood donation? Learn more about blood donation types here. Blood Safety and Testing The blood supply ...

Michigan transportation facts & figures : public transportation

Science.gov (United States)

2002-08-16

This on-line document is part of a series, Transportation Facts & Figures, by the Michigan Department of Transportation (MDOT). The Public Transit section of Transportation Facts & Figures cover such topics as intercity bus service, intercity rail se...

Communicating facts through third-party partnerships

International Nuclear Information System (INIS)

Kearns, K.D.

1989-01-01

Every day in the United States people are making decisions about the future of nuclear energy, while it continues to be one of our most controversial issues. How these decisions turn out and whether they are based on fact and need or fear and misconceptions will depend in large part on how active a role knowledgeable people choose to play in the public arena. The participation of scientists and engineers, industry employees, and operators is particularly important because of the respect the public has for their knowledge of the issues. There are a number of very successful programs in which individuals participate through meaningful partnerships with larger national public information efforts. This paper reviews two such partnership programs and makes generalized conclusions about their success and their importance

Fuels planning: science synthesis and integration; social issues fact sheet 09: Benefits of collaboration

Science.gov (United States)

Christine Esposito

2006-01-01

Wildland fire professionals at the Federal, State, and local levels have a long tradition of collaborating across agencies and jurisdictions to achieve goals that they could not achieve independently. This fact sheet discusses the reasons and resources for collaboration.Other...

It's Indisputable: Five Facts About Planning and Operating Modern Power Systems

Energy Technology Data Exchange (ETDEWEB)

Bloom, Aaron; Helman, Udi; Holttinen, Hannele; Summers, Kate; Bakke, Jordan; Brinkman, Gregory; Lopez, Anthony

2017-11-01

An indisputable fact cannot be rebutted. It is supported by theory and experience. Over the past 25 years, wind and solar generation has undergone dramatic growth, resulting in a variety of experiences that model the integration of wind and solar into the planning and operation of modern electric power systems. In this article, we bring together examples from Europe, North America, and Australia to identify five indisputable facts about planning and operating modern power systems. Taken together, we hope these experiences can help build consensus among the engineering and public policy communities about the current state of wind and solar integration and also facilitate conversations about evolving future challenges.

Emulsion-based encapsulation and delivery of nanoparticles for the controlled release of alkalinity within the subsurface environment

Science.gov (United States)

Ramsburg, C. A.; Muller, K.; Gill, J.

2012-12-01

Many current approaches to managing groundwater contamination rely on further advances in amendment delivery in order to initiate and sustain contaminant degradation or immobilization. In fact, limited or ineffective delivery is often cited when treatment objectives are not attained. Emulsions, specifically oil-in-water emulsions, have demonstrated potential to aid delivery of remediation amendments. Emulsions also afford opportunities to control the release of active ingredients encapsulated within the droplets. Our research is currently focused on the controlled release of nanoparticle-based buffering agents using oil-in-water emulsions. This interest is motivated by the fact that chemical and biological processes employed for the remediation and stewardship of contaminated sites often necessitate control of pH during treatment and, in some cases, long thereafter. Alkalinity-release nanoparticles (e.g., CaCO3, MgO) were suspended within soybean oil and subsequently encapsulated by through the creation of oil-in-water emulsions. These oil-in-water emulsions are designed to have physical properties which are favorable for subsurface delivery (nominal properties: 1 g/mL density; 10 cP viscosity; and 1.5 μm droplet diameter). Buffer capacity titrations suggest that MgO particles are moderately more accessible within the oil phase and nearly twice as effective (on a per mass basis) at releasing alkalinity (as compared to the CaCO3 particles). Results from experiments designed to assess the release kinetics suggest that a linear driving force model is capable of describing the release process and mass transfer coefficients are constant through the reactive life of the emulsion. The release kinetics in emulsions containing MgO particles were found to be three orders of magnitude faster than those quantified for emulsions containing CaCO3. The slower release kinetics of the emulsions containing CaCO3 particles may prove beneficial when considering pH control at sites

Radioactivity release vs probability for a steam generator tube rupture accident

International Nuclear Information System (INIS)

Buslik, A.J.; Hall, R.E.

1978-01-01

A calculation of the probability of obtaining various radioactivity releases from a steam generator tube rupture (SGTR) is presented. The only radioactive isotopes considered are Iodine-131 and Xe-133. The particular accident path considered consists of a double-ended guillotine SGTR followed by loss of offsite power (LOSP). If there is no loss of offsite power, and no system fault other than the SGTR, it is judged that the consequences will be minimal, since the amount of iodine released through the condenser air ejector is expected to be quite small; this is a consequence of the fact that the concentration of iodine in the vapor released from the condenser air ejector is very small compared to that dissolved in the condensate water. In addition, in some plants the condenser air ejector flow is automatically diverted to containment or a high-activity alarm. The analysis presented here is for a typical Westinghouse PWR such as described in RESAR-3S

Main facts 1995

International Nuclear Information System (INIS)

1996-01-01

This report presents the main facts of the studies carried out by the Direction des Etudes et Recherches (DER) of Electricite de France: new applications of electricity, classical and nuclear thermal power plants, electrical equipment, environment protection, monitoring and plants operations

Measuring Nanomaterial Release from Carbon Nanotube Composites: Review of the State of the Science

International Nuclear Information System (INIS)

Harper, Stacey; Wohlleben, Wendel; Doa, Maria; Nowack, Bernd; Clancy, Shaun; Canady, Richard; Maynard, Andrew

2015-01-01

Hazard studies of “as-produced” nanomaterials are increasingly available, yet a critical gap exists in exposure science that may impede safe development of nanomaterials. The gap is that we do not understand what is actually released because nanomaterials can change when released in ways that are not understood. We also generally do not have methods capable of quantitatively measuring what is released to support dose assessment. This review presents a case study of multi-walled carbon nanotubes (MWCNTs) for the measurement challenge to bridge this gap. As the use and value of MWCNTs increases, methods to measure what is released in ways relevant to risk evaluation are critically needed if products containing these materials are to be economically, environmentally, and socially sustainable. This review draws on the input of over 50 experts engaged in a program of workshops and technical report writing to address the release of MWCNTs from nanocomposite materials across their life cycle. The expert analyses reveals that new and sophisticated methods are required to measure and assess MWCNT exposures for realistic exposure scenarios. Furthermore, method requirements vary with the materials and conditions of release across life cycle stages of products. While review shows that the likelihood of significant release of MWCNTs appears to be low for many stages of composite life cycle, measurement methods are needed so that exposures from MWCNT-composites are understood and managed. In addition, there is an immediate need to refocus attention from study of “as-produced” nanomaterials to coordinated research on actual release scenarios. (paper)

Looking for optimal number and placement of FACTS devices to manage the transmission congestion

International Nuclear Information System (INIS)

Rahimzadeh, Sajad; Tavakoli Bina, Mohammad

2011-01-01

Some applications of FACTS devices show that they are proper and effective tools to control the technical parameters of power systems. However determination of optimal number, location, size and type of these devices is a difficult problem. Moreover, applying a suitable objective function for optimal placement of FACTS devices plays a very important role in economic improvement of a power market. In this paper optimal placement of parallel and series FACTS devices is studied. The STATCOM is selected as a parallel FACTS device and SSSC as a series one. The optimization problem is formulated in regard to restructured environment and a new objective function is defined so that its minimization can alleviate the congestion and provide fairer conditions for power market participants. Moreover, an index based on objective function value is presented to determine the optimal number of each FACTS device in a specific designed algorithm. The power injection models for STATCOM and SSSC are adopted by applying neural models based on the averaging technique. This model takes the converter power losses into account and produces the required PQ-phasor that is suitable for power system steady state analysis. The proposed method is applied on modified IEEE 14-bus, 30-bus and 118-bus test systems and the results are analyzed.

Selection of Hydrological Model for Waterborne Release

International Nuclear Information System (INIS)

Blanchard, A.

1999-01-01

Following a request from the States of South Carolina and Georgia, downstream radiological consequences from postulated accidental aqueous releases at the three Savannah River Site nonreactor nuclear facilities will be examined. This evaluation will aid in determining the potential impacts of liquid releases to downstream populations on the Savannah River. The purpose of this report is to evaluate the two available models and determine the appropriate model for use in following waterborne release analyses. Additionally, this report will document the accidents to be used in the future study

State Health Facts

Science.gov (United States)

... Infants who were Breastfed June 1, 2018 Teen Birth Rate per 1,000 Population Ages 15-19 June ... access, and costs, as well as demographic and economic data, into interactive custom reports for a single ...

Main facts 1993

International Nuclear Information System (INIS)

1994-01-01

This report presents the main facts of the studies carried out by the Direction des Etudes et Recherches (DER) of Electricite de France: new applications of electricity, classical and nuclear thermal power plants, electrical equipment, environment protection, network analysis, information and informatic equipment

Tuberculosis Facts - You Can Prevent TB

Science.gov (United States)

Tuberculosis (TB) Facts You Can Prevent TB What is TB? “TB” is short for a disease called tuberculosis. TB is spread through the air from one ... Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination TB Facts: You Can Prevent TB What ...

Tuberculosis Facts - TB Can Be Treated

Science.gov (United States)

Tuberculosis (TB) Facts TB Can Be Treated What is TB? “TB” is short for a disease called tuberculosis. TB is spread through the air from one ... Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination Page 1 of 2 TB Facts: TB ...

Modeling of fission product release in integral codes

International Nuclear Information System (INIS)

Obaidurrahman, K.; Raman, Rupak K.; Gaikwad, Avinash J.

2014-01-01

The Great Tohoku earthquake and tsunami that stroke the Fukushima-Daiichi nuclear power station in March 11, 2011 has intensified the needs of detailed nuclear safety research and with this objective all streams associated with severe accident phenomenology are being revisited thoroughly. The present paper would cover an overview of state of art FP release models being used, the important phenomenon considered in semi-mechanistic models and knowledge gaps in present FP release modeling. Capability of FP release module, ELSA of ASTEC integral code in appropriate prediction of FP release under several diversified core degraded conditions will also be demonstrated. Use of semi-mechanistic fission product release models at AERB in source-term estimation shall be briefed. (author)

Fuels planning: science synthesis and integration; forest structure and fire hazard fact sheet 06: Guide to fuel treatments in dry forests of the Western United States: assessing forest structure and fire hazard

Science.gov (United States)

Rocky Mountain Research Station USDA Forest Service

2005-01-01

The Guide to Fuel Treatments analyzes a range of potential silvicultural thinnings and surface fuel treatments for 25 representative dry-forest stands in the Western United States. The guide provides quantitative guidelines and visualization for treatment based on scientific principles identified for reducing potential crown fires. This fact sheet identifies the...

The National Program for Occupational Safety and Health in Agriculture. 1992 Project Facts.

Science.gov (United States)

National Inst. for Occupational Safety and Health (DHHS/PHS), Cincinnati, OH.

This book contains information about a project instituted in 1990 by the National Institute for Occupational Safety and Health (NIOSH) to prevent work-related diseases and injuries among agricultural workers. Included are facts about 25 projects within NIOSH and 42 cooperative agreements between NIOSH and institutions in 25 states. These…

Fact sheet on thyroid test in Fukushima prefecture

International Nuclear Information System (INIS)

Hiranuma, Yuri

2017-01-01

Fukushima Prefecture chose about 360,000 people who were 18 years old or younger at the time of the accident at Fukushima Daiichi NPS on March 11, 2011, and started thyroid test as part of the prefectural health survey on October 9, 2011. The survey is entrusted to Fukushima Medical University of Medicine from Fukushima Prefecture. This fact sheet summarizes the current state of thyroid test in Fukushima Prefecture. A considerable amount of data and related information have been accumulated in the seventh year from the beginning. However, especially the information disclosed in English by people concerned combined the results of the second round, which was not analyzed properly, with those of the first round. This fact gives a suspicion of intention to deny the possibility of radiation influence in such a way as to make it invisible even if there was the influence. This study firstly prepared an English fact sheet to convey the actual situation in English. However, since some official information/views were contained in papers only available in English, this study also prepared the Japanese version for enabling to grasp the current situation. The Japanese version is supplemented with explanation rather than the Japanese translation of the English version, in order to make it easier to understand. The future of thyroid test is a topic that is causing controversy. Now that the transparency, scientific fairness, and the data integrity of Fukushima Medical University are suspected, it is extremely important that an independent analysis in the true sense is to be performed by qualified experts based on the latest evidence. (A.O.)

Should repository release criteria be based on collective dose, release limits, or individual doses?

International Nuclear Information System (INIS)

Channell, J.K.; Neill, R.H.

1999-01-01

The advantages and disadvantages of using each of 3 alternative methods (collective dose, release limits, and individual dose) as release criteria for determining long-term high level or transuranic waste repository performance of naturally occurring releases or man-made intrusions are evaluated. Each of the alternative approaches have positive aspects and each has uncertainties that require some arbitrary assumptions. A comparison of the numerical results from evaluating the three alternatives at WIPP leads to the conclusion that a collective dose is preferable because it is more site specific and allows consideration of the full effects of human intrusion. The main objection to release limits is they do not use site specific criteria to determine the radiological effect on local and regional populations. Individual dose criteria used and recommended in the United States have ignored doses to drillers and the public from wastes brought to the surface by human intrusion because these doses can be greater than acceptable limits. Also, there is disagreement about defining the location and lifestyle of the individual

Estimation of North American population doses resulting from radon-222 release in western United States: methodology

International Nuclear Information System (INIS)

Fields, D.E.; Travis, C.C.; Watson, A.P.; McDowell-Boyer, L.M.

1979-12-01

The report represents a compilation of computer codes used to estimate potential human exposures and inhalation doses due to unit releases of 222 Rn from uranium milling sites in western United States. The populations considered for potential exposure to risk from 222 Rn and associated daughters are the inhabitants of North America between 20 0 and 60 0 North latitude. The primary function of these codes is to integrate spatially atmospheric radionuclide concentrations with current population data for the geographic area under consideration. It is expected that these codes will be of assistance to anyone interested in assessing nuclear or nonnuclear population exposures over large geographic areas

The State of Hispanic Health, 1992. Facing the Facts.

Science.gov (United States)

ASPIRA Association, Inc., Washington, DC. National Office.

This publication offers an overview of the health of Hispanic Americans in the United States. Topics covered include the following: (1) Hispanic representation in health fields; (2) access to health care; (3) maternal and child health; (4) substance abuse; (5) Acquired Immune Deficiency Syndrome and Hispanics; (6) Hispanic elderly; (7) migrant…

Pseudomonas - Fact Sheet

OpenAIRE

Public Health Agency

2012-01-01

Fact sheet on Pseudomonas, including:What is Pseudomonas?What infections does it cause?Who is susceptible to pseudomonas infection?How will I know if I have pseudomonas infection?How can Pseudomonas be prevented from spreading?How can I protect myself from Pseudomonas?How is Pseudomonas infection treated?

Role of fission gas release in reactor licensing

International Nuclear Information System (INIS)

1975-11-01

The release of fission gases from oxide pellets to the fuel rod internal voidage (gap) is reviewed with regard to the required safety analysis in reactor licensing. Significant analyzed effects are described, prominent gas release models are reviewed, and various methods used in the licensing process are summarized. The report thus serves as a guide to a large body of literature including company reports and government documents. A discussion of the state of the art of gas release analysis is presented

Hazard of radioactive releases resulted from coal burning; Opasnost` vysvobozhdeniya radioaktivnykh produktov pri szhiganii uglya

Energy Technology Data Exchange (ETDEWEB)

Gabbard, V

1995-09-01

Consideration is given to the data, pointing to the fact, that coal-burning power plants release of radioactive substances, contained in gaseous wastes, is not less, than the same one of nuclear power plants. The necessity of regulating emission of these substance in atmosphere by analogy with nuclear power industry is shown. 1 fig.

Spina Bifida: General Information. Fact Sheet Number 12 = La Espina Bifida: Informacion General. Fact Sheet Number 12.

Science.gov (United States)

National Information Center for Children and Youth with Disabilities, Washington, DC.

This fact sheet offers definitions of the three types of spina bifida, outlines their incidence, describes characteristics of individuals with spina bifida, and reviews educational implications. The fact sheet emphasizes that school programs should be flexible to accommodate these students' special needs and frequent absences, that children with…

Electronic Nicotine Delivery Systems Key Facts Infographic

Data.gov (United States)

U.S. Department of Health & Human Services — Explore the Electronic Nicotine Delivery Systems Key Facts Infographic which outlines key facts related to electronic nicotine delivery systems (ENDS), including...

United States Nuclear Regulatory Commission research program on core debris/concrete interactions and ex-vessel fission-product release

International Nuclear Information System (INIS)

Burson, S.B.

1987-01-01

The study of core debris/concrete interaction phenomena has been a significant element of the NRC's Severe Accident Research Program for a number of years. The CORCON and VANESA codes used to predict the consequences of high-temperature debris attack on concrete and fission-product aerosol release are state-of-the-art computational tools. The major thrust of current NRC sponsored research focuses on the refinement, verification, and validation of these codes. An overview of the analytical and experimental aspects of the NRC research program is presented

Reciprocal links between metabolic and ionic events in islet cells. Their relevance to the rhythmics of insulin release.

Science.gov (United States)

Malaisse, W J

1998-02-01

The notion of reciprocal links between metabolic and ionic events in islet cells and the rhythmics of insulin release is based on (i) the rhythmic pattern of hormonal release from isolated perfused rat pancreas, which supports the concept of an intrapancreatic pacemaker; (ii) the assumption that this phasic pattern is due to the integration of secretory activity in distinct functional units, e.g. distinct islets; and (iii) the fact that reciprocal coupling between metabolic and ionic events is operative in the secretory sequence.

Design and evaluation of nicorandil extended-release tablet

Directory of Open Access Journals (Sweden)

Ju-Young Kim

2015-04-01

Full Text Available The aim of this study was to design and evaluate extended-release formulations of a model drug, nicorandil, in order to achieve the desired steady-state plasma concentration of drug in vivo. Simulation was employed to estimate optimum dissolution and absorption rate of nicorandil. The dissolution test was employed using pH 1.2, 4.0, 6.8 buffer solution, or water, to measure the in vitro release behaviors of nicorandil formulations. A single dose (15 mg of each formulation was orally administered to four beagle dogs under fasted conditions, and the pharmacokinetic parameters were calculated. The in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle dogs. Nicorandil was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release tablets. The nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release formulation. The release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extended-release formulations. These results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

Fact sheets relating to use of geothermal energy in the United States

Energy Technology Data Exchange (ETDEWEB)

None

1980-12-01

A compilation of data relating to geothermal energy in each of the 50 states is presented. The data are summarized on one page for each state. All summary data sheets use a common format. Following the summary data sheet there are additional data on the geology of each state pertaining to possible hydrothermal/geothermal resources. Also there is a list of some of the reports available pertaining to the state and state energy contacts. The intent of these documents is to present in a concise form reference data for planning by the Department of Energy.

Adsorption and release of ofloxacin from acid- and heat-treated halloysite.

Science.gov (United States)

Wang, Qin; Zhang, Junping; Zheng, Yue; Wang, Aiqin

2014-01-01

Halloysite nanotube is an ideal vehicle of the controlled release of drugs. In this study, we systematically investigated the effects of acid- and heat-treatments on the physicochemical properties, structure and morphology of halloysite by XRD, FTIR, SEM and TEM. Afterwards, the adsorption and in vitro release properties of halloysite for cationic ofloxacin (OFL) were evaluated. The results indicate that HCl treatment has no influence on the crystal structure of halloysite, whereas it becomes amorphous after calcined at temperature higher than 500 °C. Both acid- and heat-treatments have no evident influence on the tubular structure of halloysite. OFL was adsorbed onto halloysite via electrostatic interaction between protonated OFL and negative halloysite surface, cation exchange as well as electrostatic interaction between the OFL-Al(3+) complexes and the negative halloysite surface. Acid-treatment facilitates the release of the adsorbed OFL compared with the natural halloysite in spite of a slight decrease of adsorption capacity. However, heat-treatment results in a sharp decrease of adsorption capacity for OFL owning to the OFL-promoted dissolution of aluminum and the disappearance of the porous structure. Although heat-treatment also facilitates release of the adsorbed OFL, the amount of OFL released is in fact less than the natural halloysite owing to the very low adsorption capacity. Thus, acid-activation is an effective protocol to improve the adsorption and release of halloysite for cationic drug molecules. Copyright © 2013 Elsevier B.V. All rights reserved.

Metabolic control of vesicular glutamate transport and release.

Science.gov (United States)

Juge, Narinobu; Gray, John A; Omote, Hiroshi; Miyaji, Takaaki; Inoue, Tsuyoshi; Hara, Chiaki; Uneyama, Hisayuki; Edwards, Robert H; Nicoll, Roger A; Moriyama, Yoshinori

2010-10-06

Fasting has been used to control epilepsy since antiquity, but the mechanism of coupling between metabolic state and excitatory neurotransmission remains unknown. Previous work has shown that the vesicular glutamate transporters (VGLUTs) required for exocytotic release of glutamate undergo an unusual form of regulation by Cl(-). Using functional reconstitution of the purified VGLUTs into proteoliposomes, we now show that Cl(-) acts as an allosteric activator, and the ketone bodies that increase with fasting inhibit glutamate release by competing with Cl(-) at the site of allosteric regulation. Consistent with these observations, acetoacetate reduced quantal size at hippocampal synapses and suppresses glutamate release and seizures evoked with 4-aminopyridine in the brain. The results indicate an unsuspected link between metabolic state and excitatory neurotransmission through anion-dependent regulation of VGLUT activity. Copyright © 2010 Elsevier Inc. All rights reserved.

16 CFR 460.13 - Fact sheets.

Science.gov (United States)

2010-01-01

... INSULATION § 460.13 Fact sheets. If you are a manufacturer, you must give retailers and installers fact... uses. (b) A heading: “This is ____ insulation.” Fill in the blank with the type and form of your... compressed during installation.” (e) After the chart and any statement dealing with the specific type of...

Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations

DEFF Research Database (Denmark)

Andersen, O; Nielsen, M K; Eriksen, P B

1983-01-01

Ten healthy volunteers received two sustained-release preparations as a single and multiple dose regimen in an open crossover study. Plasma theophylline concentrations were measured by an enzyme immunoassay. The limited fluctuation of the theophylline levels at steady state, with twice daily...... formulation, whereas this was not the case for the other (r = 0.27 and 0.49). The daily dose necessary to keep the plasma concentration within the therapeutic range of 55-110 mumole/liter varied from 7.9 to 22.9 mg/kg. Only mild side effects were recorded, but they were not correlated to the plasma...... theophylline concentration....

International nuclear waste management fact book

International Nuclear Information System (INIS)

Abrahms, C.W.; Patridge, M.D.; Widrig, J.E.

1995-11-01

The International Nuclear Waste Management Fact Book has been compiled to provide current data on fuel cycle and waste management facilities, R and D programs, and key personnel in 24 countries, including the US; four multinational agencies; and 20 nuclear societies. This document, which is in its second year of publication supersedes the previously issued International Nuclear Fuel Cycle Fact Book (PNL-3594), which appeared annually for 12 years. The content has been updated to reflect current information. The Fact Book is organized as follows: National summaries--a section for each country that summarizes nuclear policy, describes organizational relationships, and provides addresses and names of key personnel and information on facilities. International agencies--a section for each of the international agencies that has significant fuel cycle involvement and a list of nuclear societies. Glossary--a list of abbreviations/acronyms of organizations, facilities, and technical and other terms. The national summaries, in addition to the data described above, feature a small map for each country and some general information that is presented from the perspective of the Fact Book user in the US

International nuclear waste management fact book

Energy Technology Data Exchange (ETDEWEB)

Abrahms, C W; Patridge, M D; Widrig, J E

1995-11-01

The International Nuclear Waste Management Fact Book has been compiled to provide current data on fuel cycle and waste management facilities, R and D programs, and key personnel in 24 countries, including the US; four multinational agencies; and 20 nuclear societies. This document, which is in its second year of publication supersedes the previously issued International Nuclear Fuel Cycle Fact Book (PNL-3594), which appeared annually for 12 years. The content has been updated to reflect current information. The Fact Book is organized as follows: National summaries--a section for each country that summarizes nuclear policy, describes organizational relationships, and provides addresses and names of key personnel and information on facilities. International agencies--a section for each of the international agencies that has significant fuel cycle involvement and a list of nuclear societies. Glossary--a list of abbreviations/acronyms of organizations, facilities, and technical and other terms. The national summaries, in addition to the data described above, feature a small map for each country and some general information that is presented from the perspective of the Fact Book user in the US.

Cholera Fact Sheet

Science.gov (United States)

... news-room/fact-sheets/detail/cholera","@context":"http://schema.org","@type":"Article"}; العربية 中文 français русский español ... that includes feedback at the local level and information-sharing at the global level. Cholera cases are ...

Concerns in assessing radiological releases to a major estuary

International Nuclear Information System (INIS)

Foldesi, Leslie P.

1989-01-01

Full text: In the State of Virginia, the James River flows into the Chesapeake Bay and from the mouth of the James River to the fall line the river is under the influence of tidal forces. There are several centers of commerce along the river including an international port of call at the mouth of the James. Associated with the centers of commerce are potential sources of radioactive materials for being released to the river. Two hundred miles inland, the Babcock and Wilcox nuclear fuels processing plants are situated along-side the James River, which has been known to flood its banks quickly in the mountainous regions of Virginia. Storage tanks have been swept downstream from this facility in a previous flood. Fortunately, the tanks were not destroyed. Another source of a possible release is the Suny Nuclear Power Station located on the James River about fifty miles from the Chesapeake Bay. In the cities of Norfolk and Newport News, shipyards are fueling and defueling the Navy's nuclear powered fleet. In addition, many of the Navy's ships are carrying nuclear weapons. These activities may also result in an inadvertent release. In assessing the radiological release from any one of the previously mentioned activities, it is obvious that dilution of the material released into the river is a major factor in dose assessment, as well as the fact that the water is brackish and not suitable as a source of potable water. However, dilution in this case may not be the simple solution. We also have to remember that this estuary is under tidal effects, which means that the materials may not be going out to sea to be further diluted as quickly as we would like to think. It may be possible that the material will be carried up river as far as the fall line and deposited, or deposited along the river's banks. From Virginia's experience with the pesticide, Kepone, materials may be deposited along the estuary and enter the food chain thereby necessitating the limitation of taking

Concerns in assessing radiological releases to a major estuary

Energy Technology Data Exchange (ETDEWEB)

Foldesi, Leslie P [Virginia Department of Health, Bureau of Radiological Health, Richmond, VA (United States)

1989-09-01

Full text: In the State of Virginia, the James River flows into the Chesapeake Bay and from the mouth of the James River to the fall line the river is under the influence of tidal forces. There are several centers of commerce along the river including an international port of call at the mouth of the James. Associated with the centers of commerce are potential sources of radioactive materials for being released to the river. Two hundred miles inland, the Babcock and Wilcox nuclear fuels processing plants are situated along-side the James River, which has been known to flood its banks quickly in the mountainous regions of Virginia. Storage tanks have been swept downstream from this facility in a previous flood. Fortunately, the tanks were not destroyed. Another source of a possible release is the Suny Nuclear Power Station located on the James River about fifty miles from the Chesapeake Bay. In the cities of Norfolk and Newport News, shipyards are fueling and defueling the Navy's nuclear powered fleet. In addition, many of the Navy's ships are carrying nuclear weapons. These activities may also result in an inadvertent release. In assessing the radiological release from any one of the previously mentioned activities, it is obvious that dilution of the material released into the river is a major factor in dose assessment, as well as the fact that the water is brackish and not suitable as a source of potable water. However, dilution in this case may not be the simple solution. We also have to remember that this estuary is under tidal effects, which means that the materials may not be going out to sea to be further diluted as quickly as we would like to think. It may be possible that the material will be carried up river as far as the fall line and deposited, or deposited along the river's banks. From Virginia's experience with the pesticide, Kepone, materials may be deposited along the estuary and enter the food chain thereby necessitating the limitation of taking

Hibernia fact sheet

International Nuclear Information System (INIS)

Anon.

1994-01-01

This fact sheet gives details of the Hibernia oil field including its location, discovery date, oil company's interests in the project, the recoverable reserves of the two reservoirs, the production system used, capital costs of the project, and overall targets for Canadian benefit. Significant dates for the Hibernia project are listed. (UK)

Cerebral Palsy: General Information. Fact Sheet Number 2 = La Paralisis Cerebral: Informacion General. Fact Sheet Number 18.

Science.gov (United States)

Interstate Research Associates, McLean, VA.

This fact sheet on cerebral palsy is offered in both English and Spanish. First, it provides a definition and considers various causes (e.g., an insufficient amount of oxygen reaching the fetal or newborn brain). The fact sheet then offers incidence figures and explains characteristics of the three main types of cerebral palsy: spastic, athetoid,…

Tinnitus: Understanding the Facts

Science.gov (United States)

American Tinnitus Association Donate Become A Member Member Login Find A Provider Support Search form Search Menu Close Understanding The Facts Managing Your Tinnitus Research Toward A Cure About Us Initiatives News & ...

Whooping Cough (Pertussis) - Fact Sheet for Parents

Science.gov (United States)

... months 4 through 6 years Fact Sheet for Parents Color [2 pages] Español: Tosferina (pertussis) The best ... according to the recommended schedule. Fact Sheets for Parents Diseases and the Vaccines that Prevent Them Chickenpox ...

How to Read a Nutrition Facts Label

Medline Plus

Full Text Available ... Educators Search English Español How to Read a Nutrition Facts Label (Video) KidsHealth / For Parents / How to Read a Nutrition Facts Label (Video) Print en español Cómo leer ...

Assessment of released organics from leaf biomass on air quality in the state of California

International Nuclear Information System (INIS)

Badgett-West, C.R.; Cort, R.P.

1991-01-01

Air quality scientists today are concerned that significant amounts of volatile organic compounds (VOCs), specifically isoprenes and monoterpenes, are released by vegetative matter during biological processes. These emissions have not been previously accounted for and therefore the magnitude of their contribution to ozone concentrations has not been determined. A study of the emissions in the State of California was performed using 1987 as a base year. Data were collected on the acerages of natural and agricultural vegetation for each county in the state. Vegetation acreages were divided by season for direct input into air quality models. Generally, an inventory of the agricultural lands was more complicated than accounting for natural vegetation acreages. This was due to a large extent to crop rotation and production of more than one crop on the same land within the same calendar year. The amount of leaf biomass per acre was very difficult to define. Very little research has been completed in this area. In addition, several variables influence the amount of leaf biomass per acre. These include moisture, temperature, type of soil, insect/animal consumption, and agricultural practices

Energy: facts and figures in 2006

International Nuclear Information System (INIS)

Lavergne, R.; Nanot, B.; Scherrer, S.; Paquel, V.; Louati, S.; Thienard, H.

2007-01-01

The consumption of final energy in France in 2006 increased slightly on the whole (+0.6%) and in all sectors except the industry (-0.7%). The final energy consumption is defined as the difference between the total consumption of primary energy and the consumption of the energy production sector. The evolution of the consumption of final energy is different according to the type of energy: +4.1% for coal (due to the strong demand in the iron and steel industry), +3.6% for renewable energies (due to specific development programs), +1.5% for electrical power and no change for oil and natural gas. Despite high prices, sales of car fuels rose by 0.4%, this figure hides the fact that the sales of fuels for diesel cars rose by 2.7% (because of the growing population of diesel cars) while those of grade petrol kept on plummeting (-5.9%). It is important to note that the releases of CO 2 due to energy went down by -1.4% in 2006. The energy bill increased by +18.5% to fetch 46.2*10 9 euros despite the decrease of the imported volumes. This articles details the energy figures for France in 2006 and sheds light particularly on 3 aspects: first, the annual trends in energy since 1973, secondly, the energy bill and thirdly the figures for electricity, natural gas, solid mineral fuels, hydrocarbons and renewable sources of energy. (A.C.)

State Maternity/Parental Leave Laws. Facts on Working Women No. 90-1.

Science.gov (United States)

Women's Bureau (DOL), Washington, DC.

The status of state maternity/parental leave laws throughout the United States is depicted in eight figures and three tables. Information is reported by state for maternity/parental leave laws, months of available leave, maternity/family illness laws, days of leave for family illness, temporary disability insurance laws, temporary disability…

Structural Biology Fact Sheet

Science.gov (United States)

... NIGMS NIGMS Home > Science Education > Structural Biology Structural Biology Tagline (Optional) Middle/Main Content Area PDF Version (688 KB) Other Fact Sheets What is structural biology? Structural biology is the study of how biological ...

Cholesterol Facts and Statistics

Science.gov (United States)

... Managing High Cholesterol Cholesterol-lowering Medicine High Cholesterol Statistics and Maps High Cholesterol Facts High Cholesterol Maps ... Deo R, et al. Heart disease and stroke statistics—2017 update: a report from the American Heart ...

Nuclear fact book

Energy Technology Data Exchange (ETDEWEB)

Hill, O. F.; Platt, A. M.; Robinson, J. V. [comps

1983-05-01

This reference provides significant highlights and summary facts in the following areas: general energy; nuclear energy; nuclear fuel cycle; uranium supply and enrichment; nuclear reactors; spent fuel and advanced repacking concepts; reprocessing; high-level waste; gaseous waste; transuranic waste; low-level waste; remedial action; transportation; disposal; radiation information; environment; legislation; socio-political aspects; conversion factors; and a glossary. (GHT)

Controlled release of ibuprofen by meso-macroporous silica

Science.gov (United States)

Santamaría, E.; Maestro, A.; Porras, M.; Gutiérrez, J. M.; González, C.

2014-02-01

Structured meso-macroporous silica was successfully synthesized from an O/W emulsion using decane as a dispersed phase. Sodium silicate solution, which acts as a silica source and a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (EO19PO39EO19) denoted as P84 was used in order to stabilize the emulsion and as a mesopore template. The materials obtained were characterized through transmission electron microscopy (TEM), scanning electron microscopy (SEM), small-angle X-ray diffraction scattering (SAXS) and nitrogen adsorption-desorption isotherms. Ibuprofen (IBU) was selected as the model drug and loaded into ordered meso-macroporous materials. The effect of the materials’ properties on IBU drug loading and release was studied. The results showed that the loading of IBU increases as the macropore presence in the material is increased. The IBU adsorption process followed the Langmuir adsorption isotherm. A two-step release process, consisting of an initial fast release and then a slower release was observed. Macropores enhanced the adsorption capacity of the material; this was probably due to the fact that they allowed the drug to access internal pores. When only mesopores were present, ibuprofen was probably adsorbed on the mesopores close to the surface. Moreover, the more macropore present in the material, the slower the release behaviour observed, as the ibuprofen adsorbed in the internal pores had to diffuse along the macropore channels up to the surface of the material. The material obtained from a highly concentrated emulsion was functionalized with amino groups using two methods, the post-grafting mechanism and the co-condensation mechanism. Both routes improve IBU adsorption in the material and show good behaviour as a controlled drug delivery system.

Lithium ceramics: sol-gel preparation and tritium release

International Nuclear Information System (INIS)

Renoult, O.

1994-04-01

Ceramics based on lithium aluminate (LiA1O 2 ), lithium zirconate (Li 2 ZrO 3 ) and lithium titanate (Li 2 TiO 3 ) are candidates as tritium breeder blanket materials for forthcoming nuclear fusion reactors. Lithium silico-aluminate Li 4+x A1 4-3x Si 2x O 8 (0 ≤ x ≤ 0,25) powders were synthetized from alkoxyde-hydroxyde sol-gel route. By direct sintering at 850-1100 deg C (without prior calcination), ceramics with controlled stoichiometry and homogenous microstructure were obtained. We have also prepared, using a comparable method, Li 2 Zr 1-x Ti x O 3 (x = 0, x = 0,1 et x = 1) materials. All these ceramics, with different microstructures and compositions, have been tested in out-of-reactor experiments. Concerning lithium aluminate microporous ceramics, the silicon substitution leads to a significant improvement of the tritrium release. Classical models taking into account independent surface mechanisms are not able to describe correctly the observed tritium release kinetics. We show, using a simple model, that the release kinetics is in fact limited by an intergranular diffusion followed by a desorption. The delay in tritium release, which occurs when the ceramic compacity increases, is explained in terms of an enhancement of the ionic T + diffusion path length. The energy required for desorption includes a leading term independent of hydrogen contained in the sweep gas. This term is attributed to the limiting recombination step of T + in molecular species HTO. For similar microstructures, the facility of tritium release for the different studied materials is explained by three properties: the crystal structure of the ceramic, the acidity of oxides and finally the presence of electronic non-stoichiometric defects. (author). 89 refs., 50 figs., 2 tabs., 1 annexe

Food Preparation. I: Food Facts for Home. II: Facts about Foodservice.

Science.gov (United States)

Procter and Gamble Educational Services, Cincinnati, OH.

This package is intended for use in home economics classes focusing on nutrition and food preparation and service. The teaching guide is divided into two parts. The first centers on selected first-time facts on nutrition, meal planning, and basic food preparation skills. It includes modules on nutrition, meal management, initial steps in food…

The offshore hydrocarbon releases (HCR) database

International Nuclear Information System (INIS)

Bruce, R.A.P.

1995-01-01

Following Cullen Recommendation 39 which states that: ''The regulatory body should be responsible for maintaining a database with regard to hydrocarbon leaks, spills, and ignitions in the Industry and for the benefit of Industry'', HSE Offshore Safety Division (HSE-OSD) has now been operating the Hydrocarbon Releases (HCR) Database for approximately 3 years. This paper deals with the reporting of Offshore Hydrocarbon Releases, the setting up of the HCR Database, the collection of associated equipment population data, and the main features and benefits of the database, including discussion on the latest output information. (author)

Request for approval, vented container annual release fraction

International Nuclear Information System (INIS)

HILL, J.S.

1999-01-01

In accordance with the approval conditions for Modification to the Central Waste Complex (CWC) Radioactive Air Emissions Notice of Construction (NOC). dated August 24,1998, a new release fraction has been developed for submittal to the Washington State Department of Health (WDOH). The proposed annual release fraction of 2.50 E-14 is proposed for use in future NOCs involving the storage and handling operations associated with vented containers on the Hanford Site. The proposed annual release fraction was the largest release fraction calculated from alpha measurements of the NucFil filters from 10 vented containers consisting of nine 55-gallon drums and one burial box with dimensions of 9.3 x 5.7 x 6.4 feet. An annual release fraction of 2.0 E-09 was used in the modification to the CWC radioactive air emissions NOC. This study confirmed that the release fraction used in the CWC radioactive air emissions NOC was conservative

Structure of a low-population intermediate state in the release of an enzyme product.

Science.gov (United States)

De Simone, Alfonso; Aprile, Francesco A; Dhulesia, Anne; Dobson, Christopher M; Vendruscolo, Michele

2015-01-09

Enzymes can increase the rate of biomolecular reactions by several orders of magnitude. Although the steps of substrate capture and product release are essential in the enzymatic process, complete atomic-level descriptions of these steps are difficult to obtain because of the transient nature of the intermediate conformations, which makes them largely inaccessible to standard structure determination methods. We describe here the determination of the structure of a low-population intermediate in the product release process by human lysozyme through a combination of NMR spectroscopy and molecular dynamics simulations. We validate this structure by rationally designing two mutations, the first engineered to destabilise the intermediate and the second to stabilise it, thus slowing down or speeding up, respectively, product release. These results illustrate how product release by an enzyme can be facilitated by the presence of a metastable intermediate with transient weak interactions between the enzyme and product.

Facts about Birth Defects

Science.gov (United States)

... label> Information For… Media Policy Makers Facts about Birth Defects Language: English (US) Español (Spanish) Recommend on ... having a baby born without a birth defect. Birth Defects Are Common Every 4 ½ minutes, a ...

Surface-Engineered Nanocontainers Based on Molecular Self-Assembly and Their Release of Methenamine

Directory of Open Access Journals (Sweden)

Minghui Zhang

2018-02-01

Full Text Available The mixing of polymers and nanoparticles is opening pathways for engineering flexible composites that exhibit advantageous functional properties. To fabricate controllable assembling nanocomposites for efficiently encapsulating methenamine and releasing them on demand, we functionalized the surface of natural halloysite nanotubes (HNTs selectively with polymerizable gemini surfactant which has peculiar aggregation behavior, aiming at endowing the nanomaterials with self-assembly and stimulative responsiveness characteristics. The micromorphology, grafted components and functional groups were identified using transmission electron microscopy (TEM, thermogravimetric analysis (TGA, Fourier transform infrared (FTIR spectroscopy, and X-ray photoelectron spectroscopy (XPS. The created nanocomposites presented various characteristics of methenamine release with differences in the surface composition. It is particularly worth mentioning that the controlled release was more efficient with the increase of geminized monomer proportion, which is reasonably attributed to the fact that the amphiphilic geminized moieties with positive charge and obvious hydrophobic interactions interact with the outer and inner surface in different ways through fabricating polymeric shell as release stoppers at nanotube ends and forming polymer brush into the nanotube lumen for guest immobilization. Meanwhile, the nanocomposites present temperature and salinity responsive characteristics for the release of methenamine. The combination of HNTs with conjugated functional polymers will open pathways for engineering flexible composites which are promising for application in controlled release fields.

How to Read a Nutrition Facts Label

Medline Plus

Full Text Available ... A) Staying Safe Videos for Educators Search English Español How to Read a Nutrition Facts Label (Video) ... Read a Nutrition Facts Label (Video) Print en español Cómo leer las etiquetas de datos nutricionales (video) ...

FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1.

Directory of Open Access Journals (Sweden)

Macarena Morillo-Huesca

2010-05-01

Full Text Available The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins and exhibit defects in the G1/S transition. Here we show that the dysfunction of chromatin reassembly factors, like FACT or Spt6, down-regulates the expression of the gene encoding the cyclin that modulates the G1 length (CLN3 in START by specifically triggering the repression of its promoter. The G1 delay undergone by spt16 mutants is not mediated by the DNA-damage checkpoint, although the mutation of RAD53, which is otherwise involved in histone degradation, enhances the cell-cycle defects of spt16-197. We reveal how FACT dysfunction triggers an accumulation of free histones evicted from transcribed chromatin. This accumulation is enhanced in a rad53 background and leads to a delay in G1. Consistently, we show that the overexpression of histones in wild-type cells down-regulates CLN3 in START and causes a delay in G1. Our work shows that chromatin reassembly factors are essential players in controlling the free histones potentially released from transcribed chromatin and describes a new cell cycle phenomenon that allows cells to respond to excess histones before starting DNA replication.

Facts about Type 2

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Full Text Available ... Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type 1 Type 2 Facts About Type 2 ... Planner, and tips from experts Let's Be Well: Products to help you thrive with diabetes - lets-be- ...

Facts about Type 2

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Full Text Available ... Your Risk Alert Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type 1 Type 2 Facts ... Online Community Site Menu Are You at Risk? Diagnosis Lower Your Risk Risk Test Alert Day Prediabetes ...

Facts about Folic Acid

Science.gov (United States)

... Information For… Media Policy Makers Facts About Folic Acid Language: English (US) Español (Spanish) Recommend on Facebook ... of the baby’s brain and spine. About folic acid Folic acid is a B vitamin. Our bodies ...

Facts about Type 2

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Full Text Available ... August 1, 2013 Last Edited: October 27, 2015 Articles from Diabetes Forecast® magazine: lp-type-2, . In this section Diabetes Basics Type 2 Facts About Type 2 Recently Diagnosed Treatment and Care Blood ...

Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155 compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen

Directory of Open Access Journals (Sweden)

Devarakonda K

2015-09-01

Full Text Available Krishna Devarakonda,1 Kenneth Kostenbader,2 Michael J Giuliani,3 Jim L Young41Department of Clinical Pharmacology, Mallinckrodt Pharmaceuticals, 2Mallinckrodt Pharmaceuticals, 3Research and Development, Mallinckrodt Pharmaceuticals, 4Department of Clinical Affairs and Program Management, Mallinckrodt Pharmaceuticals, Hazelwood, MO, USAObjective: To characterize the single-dose and steady-state pharmacokinetics (PK of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (IR/ER HB/APAP, IR HB/ibuprofen, and IR tramadol HCl/APAP.Methods: In this single-center, open-label, randomized, four-period crossover study, healthy participants received four treatments under fasted conditions: 1 a single dose of two IR/ER HB/APAP 7.5/325 mg tablets (15/650 mg total dose on day 1, followed by two tablets every 12 hours (q12h beginning on day 3; 2 a single dose of IR HB/ibuprofen 15/400 mg (divided as one 7.5/200 mg tablet at hour 0 and 6, followed by one tablet every 6 hours (q6h beginning on day 3; 3 a single dose of IR tramadol HCl/APAP 75/650 mg (divided as one 37.5/325 mg tablet at hour 0 and 6, followed by one tablet q6h beginning on day 3; and 4 a single dose of three IR/ER HB/APAP 7.5/325 mg tablets (22.5/975 mg total dose on day 1, a three-tablet initial dose at 48 hours followed by two-tablet doses q12h beginning on day 3. Hydrocodone and APAP single-dose and steady-state PK were assessed. Adverse events were monitored.Results: The PK analysis was carried out on 29 of 48 enrolled participants who completed all treatment periods. Single-dose hydrocodone exposure was similar for IR/ER HB/APAP 22.5/975 mg and IR HB/ibuprofen 15/400 mg; time to maximum observed plasma concentration was shorter and half-life was longer for IR/ER HB/APAP (22.5/975 mg and 15/650 mg vs IR HB/ibuprofen. Single-dose APAP exposure was similar for IR/ER HB/APAP 15/650 mg and IR tramadol HCl/APAP 75/650 mg. Steady-state hydrocodone and APAP exposures

Release behavior and stability of encapsulated D-limonene from emulsion-based edible films.

Science.gov (United States)

Marcuzzo, Eva; Debeaufort, Frédéric; Sensidoni, Alessandro; Tat, Lara; Beney, Laurent; Hambleton, Alicia; Peressini, Donatella; Voilley, Andrée

2012-12-12

Edible films may act as carriers of active molecules, such as flavors. This possibility confers to them the status of active packaging. Two different film-forming biopolymers, gluten and ι-carrageenans, have been compared. D-Limonene was added to the two film formulations, and its release kinetics from emulsion-based edible films was assessed with HS-SPME. Results obtained for edible films were compared with D-limonene released from the fatty matrix called Grindsted Barrier System 2000 (GBS). Comparing ι-carrageenans with gluten-emulsified film, the latter showed more interesting encapsulating properties: in fact, D-limonene was retained by gluten film during the process needed for film preparation, and it was released gradually during analysis time. D-Limonene did not show great affinity to ι-carrageenans film, maybe due to high aroma compound hydrophobicity. Carvone release from the three different matrices was also measured to verify the effect of oxygen barrier performances of edible films to prevent D-limonene oxidation. Further investigations were carried out by FT-IR and liquid permeability measurements. Gluten film seemed to better protect D-limonene from oxidation. Gluten-based edible films represent an interesting opportunity as active packaging: they could retain and release aroma compounds gradually, showing different mechanical and nutritional properties from those of lipid-based ingredients.

FACT — STATUS AND FIRST RESULTS

Directory of Open Access Journals (Sweden)

Daniela Dorner

2014-06-01

Full Text Available FACT is the first imaging Cherenkov telescope based on a camera using solid state photosensors (Geigermode Avalanche Photodiodes G-APD aka SiPM. Since October 2011, it has been taking data regularly. Apart from commissioning and calibration measurements, it has already started regular operation, where the main goal is to do long-term monitoring of bright TeV blazars. In June 2012, a flare of Mrk 501 was observed. Thanks to the robustness of the G-APDs, observations can be carried out during strong moon light without aging of the sensors. This improves the duty cycle of the instrument and provides better statistics for long-term light curves. The telescope, situated on the Canary Island of La Palma, is operated, already now, remotely from central Europe. For the future, robotic operation is planned. We report on our experiences during the commissioning, and we present first results from the first 1.5 years of observations.

CMS fact sheet : to give an overview of the basic facts on the CMS Detector, its aims and collaboration

CERN Multimedia

CMS, Outreach

2010-01-01

2-sided color print A4 size sheet containing the facts on the CMS Detector, its name, what it is designed to do, questions scientists hope to answer, collaboration members, detector parts and their functions, and other miscellaneous facts on the CMS detector

Is sexual motivational state linked to dopamine release in the medial preoptic area?

Science.gov (United States)

Kleitz-Nelson, H K; Dominguez, J M; Cornil, C A; Ball, G F

2010-04-01

The medial preoptic area (mPOA) is a key site for the dopaminergic enhancement of male sexual behavior. Dopamine release increases in the rat mPOA with mating, supporting the critical stimulatory role played by preoptic dopamine on male sexual behavior. However, it has been questioned whether dopamine is specifically related to the occurrence of male sexual behavior and not simply involved in general arousal. To address this question, we asked whether dopamine release in the mPOA is linked to the production of male sexual behavior in Japanese quail (Coturnix japonica), a species that exhibits a much shorter temporal pattern of copulation than rats and does not have an intermittent organ, resulting in a very different topography of their sexual response. Extracellular samples from the mPOA of adult sexually experienced male quail were collected every 6 min before, during, and after exposure to a female using in vivo microdialysis and analyzed using high-performance liquid chromatography with electrochemical detection. Extracellular dopamine significantly increased in the presence of a female and returned to baseline after removal of the female. However, quail that failed to copulate did not display this increased release. These findings indicate that it is not solely the presence of a female that drives dopamine release in males, but how a male responds to her. Furthermore, in quail that copulated, dopamine release did not change in samples collected during periods of no copulation. Together, these findings support the hypothesis that dopamine action in the mPOA is specifically linked to sexual motivation and not only to copulatory behavior or physical arousal.

Facts about Type 2

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Full Text Available ... org > Diabetes Basics > Type 2 Share: Print Page Text Size: A A A Listen En Español Facts ... Type 2 Education Series Hear audio clips and full recordings of past Q&A events at your ...

Facts about Type 2

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Full Text Available ... for Association Events Messaging Tools Recruiting Advocates Local Market Planning Training Webinars News & Events Advocacy News Call ... Diabetes Basics > Type 2 Share: Print Page Text Size: A A A Listen En Español Facts About ...

Facts about food irradiation: Controlling the process

International Nuclear Information System (INIS)

1991-01-01

This fact sheet briefly reviews the procedures that exist to control the process of food irradiation. It also summarizes the difficulties in identifying irradiated food, which stem from the fact that irradiation does not physically change the food or cause significant chemical changes in foods. 4 refs

Shock compression and quasielastic release in tantalum

International Nuclear Information System (INIS)

Johnson, J.N.; Hixson, R.S.; Tonks, D.L.; Gray, G.T. III

1994-01-01

Previous studies of quasielastic release in shock-loaded FCC metals have shown a strong influence of the defect state on the leading edge, or first observable arrival, of the release wave. This is due to the large density of pinned dislocation segments behind the shock front, their relatively large pinning separation, and a very short response time as determined by the drag coefficient in the shock-compressed state. This effect is entirely equivalent to problems associated with elastic moduli determination using ultrasonic methods. This is particularly true for FCC metals, which have an especially low Peierls stress, or inherent lattice resistance, that has little influence in pinning dislocation segments and inhibiting anelastic deformation. BCC metals, on the other hand, have a large Peierls stress that essentially holds dislocation segments in place at low net applied shear stresses and thus allows fully elastic deformation to occur in the complete absence of anelastic behavior. Shock-compression and release experiments have been performed on tantalum (BCC), with the observation that the leading release disturbance is indeed elastic. This conclusion is established by examination of experimental VISAR records taken at the tantalum/sapphire (window) interface in a symmetric-impact experiment which subjects the sample to a peak longitudinal stress of approximately 7.3 GPa, in comparison with characteristic code calculations. copyright 1994 American Institute of Physics

Model for calculating shock loading and release paths for multicomponent geologic media

International Nuclear Information System (INIS)

Butkovich, T.R.; Moran, B.; Burton, D.E.

1981-07-01

A model has been devised to calculate shock Hugoniots and release paths off the Hugoniots for multicomponent rocks containing silicate, carbonate, and water. Hugoniot equations of state are constructed from relatively simple measurements of rock properties including bulk density, grain density of the silicate component, and weight fractions of water and carbonate. Release paths off the composite Hugoniot are calculated by mixing release paths off the component Hugoniots according to their weight fractions. If the shock imparts sufficient energy to the component to cause vaporization, a gas equation of state is used to calculate the release paths. For less energetic shocks, the rock component will unload like a solid or liquid, taking into account the irreversible removal of air-filled porosity

Leptin inhibits and ghrelin augments hypothalamic noradrenaline release after stress.

Science.gov (United States)

Kawakami, Akio; Okada, Nobukazu; Rokkaku, Kumiko; Honda, Kazufumi; Ishibashi, Shun; Onaka, Tatsushi

2008-09-01

Metabolic conditions affect hypothalamo-pituitary-adrenal responses to stressful stimuli. Here we examined effects of food deprivation, leptin and ghrelin upon noradrenaline release in the hypothalamic paraventricular nucleus (PVN) and plasma adrenocorticotropic hormone (ACTH) concentrations after stressful stimuli. Food deprivation augmented both noradrenaline release in the PVN and the increase in plasma ACTH concentration following electrical footshocks (FSs). An intracerebroventricular injection of leptin attenuated the increases in hypothalamic noradrenaline release and plasma ACTH concentrations after FSs, while ghrelin augmented these responses. These data suggest that leptin inhibits and ghrelin facilitates neuroendocrine stress responses via noradrenaline release and indicate that a decrease in leptin and an increase in ghrelin release after food deprivation might contribute to augmentation of stress-induced ACTH release in a fasting state.

26 CFR 301.6325-1 - Release of lien or discharge of property.

Science.gov (United States)

2010-04-01

... sale before satisfaction of any Federal tax liens or claims of the United States. (4) Right of... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Release of lien or discharge of property. 301....6325-1 Release of lien or discharge of property. (a) Release of lien—(1) Liability satisfied or...

Energy in Sweden. Facts and figures 2005

International Nuclear Information System (INIS)

2005-12-01

Energy in Sweden. Facts and Figures 2005 contains the tabular data for most of the diagrams in the main publication. These data consist primarily of the results of the Agency's processing of basic data from Statistics Sweden. Facts and Figures is available at www.stem.se in pdf- and excel file formats. With effect from the 2001 edition, statistics are of preliminary character for the two preceding years (2003 and 2004). Breakdowns into certain types of fuels vary somewhat depending on whether preliminary or final data has been used. Further information about the statistics can be found in Energy in Sweden, chapter 8 Energy Facts

Some Surprising Introductory Physics Facts and Numbers

Science.gov (United States)

Mallmann, A. James

2016-01-01

In the entertainment world, people usually like, and find memorable, novels, short stories, and movies with surprise endings. This suggests that classroom teachers might want to present to their students examples of surprising facts associated with principles of physics. Possible benefits of finding surprising facts about principles of physics are…

Facts about Type 2

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Full Text Available ... Alert Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type 1 Type 2 Facts About Type 2 Enroll in ... Where Do I Begin With Type2? Living With Type 1 Diabetes Enroll in the Living WIth Type 2 Diabetes ...

International Nuclear Waste Management Fact Book

International Nuclear Information System (INIS)

Leigh, I.W.

1994-05-01

International Nuclear Waste Management Fact Book has been compiled in an effort to provide current data concerning fuel cycle and waste management facilities, R ampersand D programs, and key personnel in 24 countries, including the US, four multinational agencies and 21 nuclear societies. This publication succeeds the previously issued International Nuclear Fuel Cycle Fact Book (PNL-3594), which appeared annually for 13 years. While the title is different, there are no substantial changes in the content

Calculations in support of a potential definition of large release

International Nuclear Information System (INIS)

Hanson, A.L.; Davis, R.E.; Mubayi, V.

1994-05-01

The Nuclear Regulatory Commission has stated a hierarchy of safety goals with the qualitative safety goals as Level I of the hierarchy, backed up by the quantitative health objectives as Level II and the large release guideline as Level III. The large release guideline has been stated in qualitative terms as a magnitude of release of the core inventory whose frequency should not exceed 10 -6 per reactor year. However, the Commission did not provide a quantitative specification of a large release. This report describes various specifications of a large release and focuses, in particular, on an examination of releases which have a potential to lead to one prompt fatality in the mean. The basic information required to set up the calculations was derived from the simplified source terms which were obtained from approximations of the NUREG-1150 source terms. Since the calculation of consequences is affected by a large number of assumptions, a generic site with a (conservatively determined) population density and meteorology was specified. At this site, various emergency responses (including no response) were assumed based on information derived from earlier studies. For each of the emergency response assumptions, a set of calculations were performed with the simplified source terms; these included adjustments to the source terms, such as the timing of the release, the core inventory, and the release fractions of different radionuclides, to arrive at a result of one mean prompt fatality in each case. Each of the source terms, so defined, has the potential to be a candidate for a large release. The calculations show that there are many possible candidate source terms for a large release depending on the characteristics which are felt to be important

Steady-state pharmacokinetics of fluvastatin in healthy subjects following a new extended release fluvastatin tablet, Lescol XL.

Science.gov (United States)

Barilla, Denise; Prasad, Pratapa; Hubert, Martine; Gumbhir-Shah, Kavita

2004-03-01

This was an open-label, randomized, three-period, three-treatment, multiple dose, crossover study in 12 healthy male and female subjects. This study evaluated single dose and steady-state pharmacokinetics of fluvastatin following single and multiple dose administrations of a new extended release fluvastatin 8 h matrix tablet, Lescol XL 80 mg and 160 mg doses once a day. The study also included a twice a day administration of an immediate release (IR) form of fluvastatin capsule, Lescol, for comparative purposes. All doses were administered for 7 days. The safety and tolerability were also assessed. The pharmacokinetics of fluvastatin were evaluated on days 1 and 7 following each treatment. Fluvastatin systemic exposure was 50% less when administered as Lescol XL 80 mg qd compared with Lescol IR 40 mg bid. Conversely, fluvastatin systemic exposure was 22% higher when administered as Lescol XL 160 mg qd compared with Lescol IR 40 mg bid. Single doses of Lescol XL 80 mg and 160 mg were dose proportional but, deviation (30%) from dose proportionality was observed for the Lescol XL 160 mg at steady-state. There appeared to be moderate (20%-40%) accumulation of serum fluvastatin maximal concentrations and exposure after multiple doses of Lescol XL tablets. Both Lescol XL 80 mg and 160 mg showed delayed absorption and longer apparent elimination half-life compared with fluvastatin IR capsule. Single and multiple doses of fluvastatin were generally well tolerated in this healthy volunteer population. Adverse event profiles were consistent with the published safety profile of the marketed formulations. Aside from one incidence of creatine phosphokinase (CPK) elevation (following Lescol XL 160 mg qd treatment), there were no safety concerns with any of the treatments when administered acutely (7 days). Copyright 2004 John Wiley & Sons, Ltd.

Better Solar Cells and Manufacturing Processes Using NREL's Ultrafast Quantum Efficiency Method (Fact Sheet)

Energy Technology Data Exchange (ETDEWEB)

2011-08-01

Fact sheet on the FlashQE system, a 2011 R&D 100 Award winner. A solid-state optical system by NREL and Tau Science measures solar cell quantum efficiency in less than a second, enabling a suite of new capabilities for solar cell manufacturers.

Becoming Resilient: Disaster Planning and Recovery: NREL Experts Assist Before and After a Disaster (Fact Sheet)

Energy Technology Data Exchange (ETDEWEB)

Hotchkiss, E.

2014-08-01

This fact sheet provides information on how private industry; federal, state, and local governments; non-profit organizations; and communities can utilize NREL's expertise, tools, and innovations to incorporate energy efficiency and renewable energy into the planning, recovery, and rebuilding stages of disaster.

The Recidivism Patterns of Previously Deported Aliens Released from a Local Jail: Are They High-Risk Offenders?

Science.gov (United States)

Hickman, Laura J.; Suttorp, Marika J.

2010-01-01

Previously deported aliens are a group about which numerous claims are made but very few facts are known. Using data on male deportable aliens released from a local jail, the study sought to test the ubiquitous claim that they pose a high risk of recidivism. Using multiple measures of recidivism and propensity score weighting to account for…

State Alcohol-Impaired-Driving Estimates

Science.gov (United States)

... 2012 Data DOT HS 812 017 May 2014 State Alcohol-Impaired-Driving Estimates This fact sheet contains ... alcohol involvement in fatal crashes for the United States and individually for the 50 States, the District ...

Facts about Type 2

Medline Plus

Full Text Available ... from Diabetes Forecast® magazine: lp-type-2, . In this section Diabetes Basics Type 2 Facts About Type ... ensureArray(data.submitSurveyResponse.errors); $.each(surveyErrors, function () { if (this.errorField) { $('input[name="' + this.errorField + '"]').closest('.form-group') . ...

Homosexuality: Facts for Teens

Science.gov (United States)

... Talking to Your Kids About VirginityTalking to Your Kids About Sex Home Family Health Kids and Teens Homosexuality: Facts ... by: familydoctor.org editorial staff Categories: Family Health, Kids and Teens, Prevention and Wellness, Sex and Birth Control, Sex and SexualityTags: female, Gay ...

Chernobyl: the facts

International Nuclear Information System (INIS)

Radicella, Renato

2007-01-01

The Chernobyl accident and its consequences are briefly outlined in order to provide a synthesis of the facts from the most reliable sources. The paper describes in main lines the accident and the measures that were taken to mitigate its effects. The data on the radiation doses received by the population and the effects of the accident on the human health as well as on the environment are summarized. (author) [es

Fake facts and alternative truths in medical research.

Science.gov (United States)

Hofmann, Bjørn

2018-01-27

Fake news and alternative facts have become commonplace in these so-called "post-factual times." What about medical research - are scientific facts fake as well? Many recent disclosures have fueled the claim that scientific facts are suspect and that science is in crisis. Scientists appear to engage in facting interests instead of revealing interesting facts. This can be observed in terms of what has been called polarised research, where some researchers continuously publish positive results while others publish negative results on the same issue - even when based on the same data. In order to identify and address this challenge, the objective of this study is to investigate how polarised research produce "polarised facts." Mammography screening for breast cancer is applied as an example. The main benefit with mammography screening is the reduced breast cancer mortality, while the main harm is overdiagnosis and subsequent overtreatment. Accordingly, the Overdiagnosis to Mortality Reduction Ratio (OMRR) is an estimate of the risk-benefit-ratio for mammography screening. As there are intense interests involved as well as strong opinions in debates on mammography screening, one could expect polarisation in published results on OMRR. A literature search identifies 8 studies publishing results for OMRR and reveals that OMRR varies 25-fold, from 0.4 to 10. Two experts in polarised research were asked to rank the attitudes of the corresponding authors to mammography screening of the identified publications. The results show a strong correlation between the OMRR and the authors' attitudes to screening (R = 0.9). Mammography screening for breast cancer appears as an exemplary field of strongly polarised research. This is but one example of how scientists' strong professional interests can polarise research. Instead of revealing interesting facts researchers may come to fact interests. In order to avoid this and sustain trust in science, researchers should disclose

Facts in nuclear engineering

International Nuclear Information System (INIS)

Buenemann, D.

1979-07-01

This compilation of facts has been published on behalf of Kerntechnische Gesellschaft (Society for Nuclear Engineering), as a basis for the discussion between promoters and opponents of nuclear power. It intends to make the nuclear discussion less emotional by providing relevant data material. (orig./HP) [de

Facts about Vitamin K

Science.gov (United States)

Facts about Vitamin K 1 R. Elaine Turner and Wendy J. Dahl 2 FCS8666 Figure 1. Vitamin K is mostly found in vegetables, especially green ... ColognePhotos/iStock/Thinkstock, © ColognePhotos Why do we need vitamin K? Vitamin K is one of the fat- ...

Diet myths and facts

Science.gov (United States)

... night will make you fat. FACT: People who eat late at night do tend to put on extra weight. One possible reason is that late-night eaters tend to choose high-calorie treats. Some people who snack after dinner do not sleep well, which can lead to ...

31 CFR 306.95 - Attorneys in fact.

Science.gov (United States)

2010-07-01

... recognized until the Bureau receives proof of revocation or proof of the grantor's death or incompetency. (b... to by an officer who has access to the records: (1) A copy of the resolution of the governing body... fact, or (3) A copy of the resolution of the governing body directly appointing an attorney in fact. If...

EJSCREEN States Percentiles Lookup Table--2015 Public Release

Data.gov (United States)

U.S. Environmental Protection Agency — The States table provides percentile breaks of important EJSCREEN elements (demographic indicators and indexes, environmental indicators and indexes) at the state...

Youth Volunteering in the States: 2002 to 2006. Fact Sheet

Science.gov (United States)

Helms, Sara E.; Marcelo, Karlo Barrios

2007-01-01

Volunteer rates vary tremendously across states and age groups. In recent years, young people have exhibited rising volunteering rates, particularly high school students and college freshmen, but 2006 witnessed a drop in the volunteering rate among. When comparing the volunteer rates for different age groups from 2002 to 2006, 16-18 year olds…

32 CFR 705.6 - Releasing public information material to the media.

Science.gov (United States)

2010-07-01

... UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS PUBLIC AFFAIRS REGULATIONS § 705.6 Releasing public... and/or as approved by the Assistant Secretary of Defense (Public Affairs). (i) Overall responsibility for release of information rests with the Assistant Secretary of Defense (Public Affairs). The Chief...

Request for approval, vented container annual release fraction; FINAL

International Nuclear Information System (INIS)

HILL, J.S.

1999-01-01

In accordance with the approval conditions for Modification to the Central Waste Complex (CWC) Radioactive Air Emissions Notice of Construction (NOC). dated August 24,1998, a new release fraction has been developed for submittal to the Washington State Department of Health (WDOH). The proposed annual release fraction of 2.50 E-14 is proposed for use in future NOCs involving the storage and handling operations associated with vented containers on the Hanford Site. The proposed annual release fraction was the largest release fraction calculated from alpha measurements of the NucFil filters from 10 vented containers consisting of nine 55-gallon drums and one burial box with dimensions of 9.3 x 5.7 x 6.4 feet. An annual release fraction of 2.0 E-09 was used in the modification to the CWC radioactive air emissions NOC. This study confirmed that the release fraction used in the CWC radioactive air emissions NOC was conservative

Examining overlap in behavioral and neural representations of morals, facts, and preferences.

Science.gov (United States)

Theriault, Jordan; Waytz, Adam; Heiphetz, Larisa; Young, Liane

2017-11-01

Metaethical judgments refer to judgments about the information expressed by moral claims. Moral objectivists generally believe that moral claims are akin to facts, whereas moral subjectivists generally believe that moral claims are more akin to preferences. Evidence from developmental and social psychology has generally favored an objectivist view; however, this work has typically relied on few examples, and analyses have disallowed statistical generalizations beyond these few stimuli. The present work addresses whether morals are represented as fact-like or preference-like, using behavioral and neuroimaging methods, in combination with statistical techniques that can (a) generalize beyond our sample stimuli, and (b) test whether particular item features are associated with neural activity. Behaviorally, and contrary to prior work, morals were perceived as more preference-like than fact-like. Neurally, morals and preferences elicited common magnitudes and spatial patterns of activity, particularly within the dorsal-medial prefrontal cortex (DMPFC), a critical region for social cognition. This common DMPFC activity for morals and preferences was present across whole-brain conjunctions, and in individually localized functional regions of interest (targeting the theory of mind network). By contrast, morals and facts did not elicit any neural activity in common. Follow-up item analyses suggested that the activity elicited in common by morals and preferences was explained by their shared tendency to evoke representations of mental states. We conclude that morals are represented as far more subjective than prior work has suggested. This conclusion is consistent with recent theoretical research, which has argued that morality is fundamentally about regulating social relationships. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Getting a New Pancreas: Facts about Pancreas Transplants

Science.gov (United States)

... 2003 December 2006 March 2012 Getting A New Pancreas Facts About Pancreas Transplants American Society of Transplantation 1120 Route 73, ... the views of the Society. _________________________________________________________________ Getting a New Pancreas Facts About Pancreas Transplants When you get a ...

78 FR 13771 - Selection and Functions of Farm Service Agency State and County Committees

Science.gov (United States)

2013-03-01

... presentations, public service announcements, newsletters, press releases, posters, fact sheets, and success.... USDA will also respond in a timely and meaningful manner to all Tribal government requests for...

Effect of surface water on tritium release behavior from Li4SiO4

International Nuclear Information System (INIS)

Hanada, T.; Fukada, S.; Nishikawa, M.; Suematsu, K.; Yamashita, N.; Kanazawa, T.

2010-01-01

The tritium release model to represent the release behavior of bred tritium from solid breeder materials has been developed by the blanket group of Kyushu University. It has been found that water is released to the purge gas from solid breeder materials and that this water affects the tritium release behavior. In this study, the amount of surface water released from Li 4 SiO 4 is quantified by the experiment. In addition, the tritium release behavior from Li 4 SiO 4 are estimated based on the tritium release model using parameters obtained in our studies under conditions of commercial reactor operation and ITER test blanket module operation. The effect of the surface water on tritium release behavior is discussed from the obtained results. Moreover, the tritium inventory of Li 4 SiO 4 is discussed based on calculation under the unsteady state condition. Further, the effects of grain size and temperature on distribution of tritium inventory under the steady state condition are evaluated, and the optimal grain size is discussed from the view point of tritium release from Li 4 SiO 4 .

Energy in Sweden. Facts and figures 2004

International Nuclear Information System (INIS)

2004-12-01

Energy in Sweden 2004: Facts and Figures contains the tabular data for most of the diagrams in the main publication. These data consist primarily of the results of the Agency's processing of basic data from Statistics Sweden. Facts and Figures is available at www.stem.se in pdf- and excel file formats. Since the year 2001 statistics for the period 1983-1998 are revised compared to data for previous editions. With effect from the 2001 edition, statistics are of preliminary character for the two preceding years. Breakdowns into certain types of fuels vary somewhat depending on whether preliminary or final data has been used. Further information about the statistics can be found in Energy in Sweden, chapter 8 Energy Facts.

Leadership: sad facts and silver linings.

Science.gov (United States)

Peters, T J

1979-01-01

The typical CEO has endless interruptions and limited options for action. In addition, he may not even hear about his choices, or any bad news that might require action, until it is almost too late. Finally, any decision he does make will probably require months or years to implement fully. This author suggests that this gloomy picture has another side. In fact, each of these "sad facts" of managerial life can be turned into an opportunity to communicate values and to persuade, and they add up to a new notion of the chief executive's function.

Capture and release of carriers in InGaAs/GaAs quantum dots

DEFF Research Database (Denmark)

Turchinovich, Dmitry; Porte, Henrik; Daghestani, N.

2009-01-01

We observe the ultrafast capture and release of charge carriers in InGaAs/GaAs quantum dots (QDs) at room-temperature with time-resolved terahertz spectroscopy. For excitation into the barrier states, a decay of the photoinduced conductivity, due to capture of carriers into the nonconducting QD...... states is observed. The increase of the decay time constant with increasing pump fluence is attributed to filling of the QD states. In the case of resonantly excitation into the QD ground state a maximum conductivity is reached 35 ps after photoexcitation, which is assigned to the release of carriers...

Mastering the Multiplication Facts

Science.gov (United States)

D'Ettorre, Jenna

2009-01-01

The purpose of this paper is to share the results of a six-week research project (after baseline data was collected) that focused on three different strategies (flashcards, interactive games, and music) and their effectiveness in helping fifth grade students memorize the basic multiplication facts. Many teachers face a serious problem when their…

Thorndike Revisited--Some Facts

Science.gov (United States)

Tuinman, J. Jaap

1971-01-01

Examines some historical facts surrounding Thorndike's 1917 article, Reading as Reasoning: A Study of Mistakes in Paragraph Reading," (republished in Reading Research Quarterly, 1971, 6, 425-48), in an attempt to put the article in its proper perspective both as a research study and as a contribution to the psychology of reading. (VJ)

Release isentrope measurements with the LLNL electric gun

Energy Technology Data Exchange (ETDEWEB)

Gathers, G.R.; Osher, J.E.; Chau, H.H.; Weingart, R.C.; Lee, C.G.; Diaz, E.

1987-06-01

The liquid-vapor coexistence boundary is not well known for most metals because the extreme conditions near the critical point create severe experimental difficulties. The isentropes passing through the liquid-vapor region typically begin from rather large pressures on the Hugoniot. We are attempting to use the high velocities achievable with the Lawrence Livermore National Laboratory (LLNL) electric gun to obtain these extreme states in aluminum and measure the release isentropes by releasing into a series of calibrated standards with known Hugoniots. To achieve large pressure drops needed to explore the liquid-vapor region, we use argon gas for which Hugoniots have been calculated using the ACTEX code, as one of the release materials.

Best Management Practice Fact Sheet. 12, Filtering Practices

OpenAIRE

Sample, David; Barlow, Stefani

2013-01-01

This fact sheet is one of a 15-part series on urban stormwater management practices. This fact sheet discusses filtering practices, what they are, where they are used, how they work, maintenance, limitations, performance, expected costs and includes a glossary of terms.

Best Management Practice Fact Sheet. 10, Dry Swale

OpenAIRE

Sample, David; Doumar, Lia

2013-01-01

This fact sheet is one of a 15-part series on urban stormwater management practices. This fact sheet discusses dry swales, what they are, where they are used, how they work, maintenance, limitations, performance, expected costs and includes a glossary of terms.

Best Management Practice Fact Sheet. 11, Wet Swale

OpenAIRE

Sample, David; Doumar, Lia

2013-01-01

This fact sheet is one of a 15-part series on urban stormwater management practices. This fact sheet discusses wet swales, what they are, where they are used, how they work, maintenance, limitations, performance, expected costs and includes a glossary of terms.

Barrier and operational risk analysis of hydrocarbon releases (BORA-Release)

International Nuclear Information System (INIS)

Sklet, Snorre; Vinnem, Jan Erik; Aven, Terje

2006-01-01

This paper presents results from a case study carried out on an offshore oil and gas production platform with the purpose to apply and test BORA-Release, a method for barrier and operational risk analysis of hydrocarbon releases. A description of the BORA-Release method is given in Part I of the paper. BORA-Release is applied to express the platform specific hydrocarbon release frequencies for three release scenarios for selected systems and activities on the platform. The case study demonstrated that the BORA-Release method is a useful tool for analysing the effect on the release frequency of safety barriers introduced to prevent hydrocarbon releases, and to study the effect on the barrier performance of platform specific conditions of technical, human, operational, and organisational risk influencing factors (RIFs). BORA-Release may also be used to analyse the effect on the release frequency of risk reducing measures

NJ transportation fact book, 2007

Science.gov (United States)

2010-01-01

The New Jersey Transportation Fact Book 2006-07 presents information about the New Jersey Department of Transportation : and other agencies that provide transportation services in New Jersey. We hope it will prove helpful.

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... Join the Cause alz.org >> Alzheimer's & Dementia >> Home Text size: A A A 2018 Alzheimer's Disease Facts and Figures Download the full report: Download the Infographic: English Spanish Share the ...

INITIAL DATA RELEASE OF THE KEPLER-INT SURVEY

Energy Technology Data Exchange (ETDEWEB)

Greiss, S.; Steeghs, D.; Gaensicke, B. T. [Department of Physics, Astronomy and Astrophysics group, University of Warwick, CV4 7AL Coventry (United Kingdom); Martin, E. L. [INTA-CSIC Centro de Astrobiologia, Carretera de Ajalvir km 4, 28550 Torrejon de Ardoz (Spain); Groot, P. J.; Verbeek, K.; Jonker, P. G.; Scaringi, S. [Department of Astrophysics/IMAPP, Radboud University Nijmegen, P.O. Box 9010, 6500 GL Nijmegen (Netherlands); Irwin, M. J.; Gonzalez-Solares, E. [Cambridge Astronomy Survey Unit, Institute of Astronomy, University of Cambridge, Madingley Road, CB3 0HA Cambridge (United Kingdom); Greimel, R. [Institut fuer Physik, Karl-Franzen Universitaet Graz, Universitaetsplatz 5, 8010 Graz (Austria); Knigge, C. [School of Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom); Ostensen, R. H. [Instituut voor Sterrenkunde, KU Leuven, Celestijnenlaan 200D, 3001 Leuven (Belgium); Drew, J. E.; Farnhill, H. [Centre for Astrophysics Research, University of Hertfordshire, College Lane, Hatfield AL10 9AB (United Kingdom); Drake, J.; Wright, N. J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Ripepi, V. [INAF-Osservatorio Astronomico di Capodimonte, via Moiariello 16, Naples I-80131 (Italy); Southworth, J. [Astrophysics Group, Keele University, Newcastle-under-Lyme ST5 5BG (United Kingdom); Still, M., E-mail: s.greiss@warwick.ac.uk [NASA Ames Research Center, M/S 244-40, Moffett Field, CA 94035 (United States); and others

2012-07-15

This paper describes the first data release of the Kepler-INT Survey (KIS) that covers a 116 deg{sup 2} region of the Cygnus and Lyra constellations. The Kepler field is the target of the most intensive search for transiting planets to date. Despite the fact that the Kepler mission provides superior time-series photometry, with an enormous impact on all areas of stellar variability, its field lacks optical photometry complete to the confusion limit of the Kepler instrument necessary for selecting various classes of targets. For this reason, we follow the observing strategy and data reduction method used in the IPHAS and UVEX galactic plane surveys in order to produce a deep optical survey of the Kepler field. This initial release concerns data taken between 2011 May and August, using the Isaac Newton Telescope on the island of La Palma. Four broadband filters were used, U, g, r, i, as well as one narrowband one, H{alpha}, reaching down to a 10{sigma} limit of {approx}20th mag in the Vega system. Observations covering {approx}50 deg{sup 2}, thus about half of the field, passed our quality control thresholds and constitute this first data release. We derive a global photometric calibration by placing the KIS magnitudes as close as possible to the Kepler Input Catalog (KIC) photometry. The initial data release catalog containing around 6 million sources from all the good photometric fields is available for download from the KIS Web site (www.astro.warwick.ac.uk/research/kis/) as well as via MAST (KIS magnitudes can be retrieved using the MAST enhanced target search page http://archive.stsci.edu/kepler/kepler{sub f}ov/search.php and also via Casjobs at MAST Web site http://mastweb.stsci.edu/kplrcasjobs/).

INITIAL DATA RELEASE OF THE KEPLER-INT SURVEY

International Nuclear Information System (INIS)

Greiss, S.; Steeghs, D.; Gänsicke, B. T.; Martín, E. L.; Groot, P. J.; Verbeek, K.; Jonker, P. G.; Scaringi, S.; Irwin, M. J.; González-Solares, E.; Greimel, R.; Knigge, C.; Østensen, R. H.; Drew, J. E.; Farnhill, H.; Drake, J.; Wright, N. J.; Ripepi, V.; Southworth, J.; Still, M.

2012-01-01

This paper describes the first data release of the Kepler-INT Survey (KIS) that covers a 116 deg 2 region of the Cygnus and Lyra constellations. The Kepler field is the target of the most intensive search for transiting planets to date. Despite the fact that the Kepler mission provides superior time-series photometry, with an enormous impact on all areas of stellar variability, its field lacks optical photometry complete to the confusion limit of the Kepler instrument necessary for selecting various classes of targets. For this reason, we follow the observing strategy and data reduction method used in the IPHAS and UVEX galactic plane surveys in order to produce a deep optical survey of the Kepler field. This initial release concerns data taken between 2011 May and August, using the Isaac Newton Telescope on the island of La Palma. Four broadband filters were used, U, g, r, i, as well as one narrowband one, Hα, reaching down to a 10σ limit of ∼20th mag in the Vega system. Observations covering ∼50 deg 2 , thus about half of the field, passed our quality control thresholds and constitute this first data release. We derive a global photometric calibration by placing the KIS magnitudes as close as possible to the Kepler Input Catalog (KIC) photometry. The initial data release catalog containing around 6 million sources from all the good photometric fields is available for download from the KIS Web site (www.astro.warwick.ac.uk/research/kis/) as well as via MAST (KIS magnitudes can be retrieved using the MAST enhanced target search page http://archive.stsci.edu/kepler/kepler_fov/search.php and also via Casjobs at MAST Web site http://mastweb.stsci.edu/kplrcasjobs/).

State-dependent variation in the inhibitory effect of (D-Ala sup 2 , D-Leu sup 5 )-enkephalin on hippocampal serotonin release in ground squirrels

Energy Technology Data Exchange (ETDEWEB)

Kramarova, L.I.; Lee, T.F.; Cui, Y.; Wang, L.C.H. (Univ. of Alberta, Edmonton (Canada))

1990-01-01

Accumulated evidence has suggested that increased endogenous opioid activities may facilitate the onset of hibernation either directly or possibly through modulation of other neurotransmitter systems. The seasonal change of (D-Ala{sup 2}, D-Leu{sup 5})-enkephalin (DADLE), a {delta} receptor agonist, in modulating K{sup +}-induced ({sup 3}H)-5-hydroxytryptamine (5-HT) release from the hippocampal and hypothalamic slices of euthermic and hibernating Richardsons' ground squirrels was therefore investigated. DADLE had no effect on 5-HT release in the hypothalamic slices but elicited a dose-related inhibition on ({sup 3}H)-5-HT release from the hippocampal slices of the euthermic ground squirrel. The inhibitory effect of DADLE was completely reversed by naloxone, but not by tetrodotoxin. In contrast, DADLE failed to alter the K{sup +}-induced 5-HT release from the hippocampal slices of the hibernating ground squirrel. This state-dependent reduction in responsiveness to an opioid is consistent with the hypothesis that enhanced endogenous opioid activity in the hibernating phase could lead to down regulation of the opioid receptors and minimize its inhibition on hippocampal serotonergic activity. A high 5-HT activity would inhibit midbrain reticular activating system indirectly through non-serotonergic fibers, which in turn facilitate the onset or maintenance of hibernation.

Achievement of solid-state plasma fusion ('Cold-Fusion')

International Nuclear Information System (INIS)

Arata, Yoshiaki; Zhang, Yue-Chang

1995-01-01

Using a 'QMS' (Quadrupole Mass Spectrometer), the authors detected a significantly large amount (10 20 -10 21 [cm -3 ]) of helium ( 2 4 He), which was concluded to have been produced by a deuterium nuclear reaction within a host solid. These results were found to be fully repeatable and supported the authors' proposition that solid state plasma fusion ('Cold Fusion') can be generated in energetic deuterium Strongly Coupled Plasma ('SC-plasma'). This fusion reaction is thought to be sustained by localized 'Latticequake' in a solid-state media with the deuterium density equivalent to that of the host solid. While exploring this basic proposition, the characteristic differences when compared with ultra high temperature-state plasma fusion ('Hot Fusion') are clarified. In general, the most essential reaction product in both types of the deuterium plasma fusion is considered to be helium, irrespective of the 'well-known and/or unknown reactions', which is stored within the solid-state medium in abundance as a 'Residual Product', but which generally can not enter into nor be released from host-solid at a room temperature. Even measuring instruments with relatively poor sensitivity should be able to easily detect such residual helium. An absence of residual helium means that no nuclear fusion reaction has occurred, whereas its presence provides crucial evidence that nuclear fusion has, in fact, occurred in the solid. (author)

Gas Release as a Deformation Signal

Energy Technology Data Exchange (ETDEWEB)

Bauer, Stephen J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-09-01

Radiogenic noble gases are contained in crustal rock at inter and intra granular sites. The gas composition depends on lithology, geologic history, fluid phases, and the aging effect by decay of U, Th, and K. The isotopic signature of noble gases found in rocks is vastly different than that of the atmosphere which is contributed by a variety of sources. When rock is subjected to stress conditions exceeding about half its yield strength, micro-cracks begin to form. As rock deformation progresses a fracture network evolves, releasing trapped noble gases and changing the transport properties to gas migration. Thus, changes in gas emanation and noble gas composition from rocks could be used to infer changes in stress-state and deformation. The purpose of this study has been to evaluate the effect of deformation/strain rate upon noble gas release. Four triaxial experiments were attempted for a strain rate range of %7E10-8 /s (180,000s) to %7E 10-4/s (500s); the three fully successful experiments (at the faster strain rates) imply the following: (1) helium is measurably released for all strain rates during deformation, this release is in amounts 1-2 orders of magnitude greater than that present in the air, and (2) helium gas release increases with decreasing strain rate.

Atmospheric Release Advisory Capability

International Nuclear Information System (INIS)

Dickerson, M.H.; Gudiksen, P.H.; Sullivan, T.J.

1983-02-01

The Atmospheric Release Advisory Capability (ARAC) project is a Department of Energy (DOE) sponsored real-time emergency response service available for use by both federal and state agencies in case of a potential or actual atmospheric release of nuclear material. The project, initiated in 1972, is currently evolving from the research and development phase to full operation. Plans are underway to expand the existing capability to continuous operation by 1984 and to establish a National ARAC Center (NARAC) by 1988. This report describes the ARAC system, its utilization during the past two years, and plans for its expansion during the next five to six years. An integral part of this expansion is due to a very important and crucial effort sponsored by the Defense Nuclear Agency to extend the ARAC service to approximately 45 Department of Defense (DOD) sites throughout the continental US over the next three years

Dental Health: The Basic Facts

Science.gov (United States)

Dental Health THE BASIC FACTS MULTIPLE SCLEROSIS Kim, diagnosed in 1986 People with a chronic disease may neglect their general health and wellness, research shows. Dental care is no exception. A tendency to focus ...

Facts about Jaundice and Kernicterus

Science.gov (United States)

... Search Form Controls Cancel Submit Search the CDC Jaundice & Kernicterus Note: Javascript is disabled or is not ... Websites Information For… Media Policy Makers Facts about Jaundice and Kernicterus Recommend on Facebook Tweet Share Compartir ...

Definition and Facts for Constipation

Science.gov (United States)

... Causes Diagnosis Treatment Eating, Diet, & Nutrition Clinical Trials Definition & Facts for Constipation What is constipation? Constipation is ... and Treatment. New York, NY: Springer Science and Business Media; 2014. May 2018 Share Previous: Constipation Next: ...

Chemical Agents: Facts about Evacuation

Science.gov (United States)

... What CDC is Doing Blog: Public Health Matters Chemical Agents: Facts About Evacuation Format: Select One PDF [ ... on Facebook Tweet Share Compartir Some kinds of chemical accidents or attacks, such as a train derailment ...

Alzheimer's Disease Facts and Figures

Science.gov (United States)

... Dementia >> Home Text size: A A A 2018 Alzheimer's Disease Facts and Figures Download the full report: ... twice as high. Invest in a world without Alzheimer's. Donate Caregivers Eighty-three percent of the help ...

Role of various natural, synthetic and semi-synthetic polymers on drug release kinetics of losartan potassium oral controlled release tablets.

Science.gov (United States)

Jayasree, J; Sivaneswari, S; Hemalatha, G; Preethi, N; Mounika, B; Murthy, S Vasudeva

2014-10-01

The objective of the present work was to formulate and to characterize controlled release matrix tablets of losartan potassium in order to improve bioavailability and to minimize the frequency of administration and increase the patient compliance. Losartan potassium controlled release matrix tablets were prepared by direct compression technique by the use of different natural, synthetic and semisynthetic polymers such as gum copal, gum acacia, hydroxypropyl methyl cellulose K100 (HPMC K100), eudragit RL 100 and carboxy methyl ethyl cellulose (CMEC) individually and also in combination. Studies were carried out to study the influence of type of polymer on drug release rate. All the formulations were subjected to physiochemical characterization such as weight variation, hardness, thickness, friability, drug content, and swelling index. In vitro dissolution studies were carried out simulated gastric fluid (pH 1.2) for first 2 h and followed by simulated intestinal fluid (pH 6.8) up to 24 h, and obtained dissolution data were fitted to in vitro release kinetic equations in order to know the order of kinetics and mechanism of drug release. Results of physiochemical characterization of losartan potassium matrix tablets were within acceptable limits. Formulation containing HPMC K100 and CMEC achieved the desired drug release profile up to 24 h followed zero order kinetics, release pattern dominated by Korsmeyer - Peppas model and mechanism of drug release by nonfickian diffusion. The good correlation obtained from Hixson-Crowell model indicates that changes in surface area of the tablet also influences the drug release. Based on the results, losartan potassium controlled release matrix tablets prepared by employing HPMC K100 and CMEC can attain the desired drug release up to 24 h, which results in maintaining steady state concentration and improving bioavailability.

Computational Studies of Drug Release, Transport and Absorption in the Human Intestines

Science.gov (United States)

Behafarid, Farhad; Brasseur, J. G.; Vijayakumar, G.; Jayaraman, B.; Wang, Y.

2016-11-01

Following disintegration of a drug tablet, a cloud of particles 10-200 μm in diameter enters the small intestine where drug molecules are absorbed into the blood. Drug release rate depends on particle size, solubility and hydrodynamic enhancements driven by gut motility. To quantify the interrelationships among dissolution, transport and wall permeability, we apply lattice Boltzmann method to simulate the drug concentration field in the 3D gut released from polydisperse distributions of drug particles in the "fasting" vs. "fed" motility states. Generalized boundary conditions allow for both solubility and gut wall permeability to be systematically varied. We apply a local 'quasi-steady state' approximation for drug dissolution using a mathematical model generalized for hydrodynamic enhancements and heterogeneity in drug release rate. We observe fundamental differences resulting from the interplay among release, transport and absorption in relationship to particle size distribution, luminal volume, motility, solubility and permeability. For example, whereas smaller volume encourages higher bulk concentrations and reduced release rate, it also encourages higher absorption rate, making it difficult to generalize predictions. Supported by FDA.

Argon-41 ALARA, or reduction of argon-41 released from the OSTR by use of a nitrogen purging system for the rotating rack facility

International Nuclear Information System (INIS)

Johnson, A.G.; Anderson, T.V.; Dodd, B.; Carpenter, W.T.

1982-01-01

During a generally concurrent era, the NRC began emphasizing the concept of keeping all radiation doses and releases of radioactivity to the environment 'as low as reasonably achievable' (ALARA). In much the same way as the physical security regulations were expanded, the ALARA idea was defined for a number of different NRC licensee categories, but the underlying principle remained the same, namely, reduce occupational doses and releases of radioactivity. In keeping with this NRC policy (i.e., regulatory requirement), the OSTR staff conducted a study of the argon-41 production sites throughout the facility, with the idea of minimizing the production without increasing the potential for higher occupational doses to the staff. The reduction in argon-41 production and release should, after a full year's implementation, result in the 41.68 curie value documented for the past reporting year (July 1, 1980 through June 30, 1981) being cut to about 9 curies per year. This value is based on the fact that the LN purging system was used about the last four months of the stated reporting period. From a dose commitment standpoint, this should reduce the maximum projected annual dose in the unrestricted area under the worst case hypothetical conditions from the currently estimated 1.04 mrem per year to about 0.23 mrem per year

International Nuclear Fuel Cycle Fact Book

Energy Technology Data Exchange (ETDEWEB)

Leigh, I.W.; Patridge, M.D.

1991-05-01

As the US Department of Energy (DOE) and DOE contractors have become increasingly involved with other nations in nuclear fuel cycle and waste management cooperative activities, a need has developed for a ready source of information concerning foreign fuel cycle programs, facilities, and personnel. This Fact Book was compiled to meet that need. The information contained in the International Nuclear Fuel Cycle Fact Book has been obtained from many unclassified sources: nuclear trade journals and newsletters; reports of foreign visits and visitors; CEC, IAEA, and OECN/NEA activities reports; not reflect any one single source but frequently represent a consolidation/combination of information.

Enriching Addition and Subtraction Fact Mastery through Games

Science.gov (United States)

Bay-Williams, Jennifer M.; Kling, Gina

2014-01-01

The learning of "basic facts"--single-digit combinations for addition, subtraction, multiplication, and division--has long been a focus of elementary school mathematics. Many people remember completing endless worksheets, timed tests, and flash card drills as they attempted to "master" their basic facts as children. However,…

Basic Tuberculosis Facts

Centers for Disease Control (CDC) Podcasts

2012-03-12

In this podcast, Dr. Kenneth Castro, Director of the Division of Tuberculosis Elimination, discusses basic TB prevention, testing, and treatment information.  Created: 3/12/2012 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 3/12/2012.

Type 1 Diabetes Facts

Science.gov (United States)

... Affiliates JDRF Celebrity Ambassadors JDRF Logo Usage Contact Us Donate Events More Type 1 Diabetes Facts Type 1 diabetes (T1D) is an autoimmune ... about Insulin and T1D Learn More What Is Diabetes? Causes of T1D The Complexity of Diagnosing ... US CAREERS NEWSROOM FOR RESEARCHERS © JDRF 2018 • Privacy Policy • ...

DER 86: main facts

International Nuclear Information System (INIS)

1987-01-01

This report presents the important facts among the studies carried out by the Direction des Etudes et Recherches (E.D.F.): new applications of electric power for customers, protection of environment, classical equipments for power plants and nuclear equipments, monitoring and control of power plants, electrical equipments, development and operation of electrical networks, informatics and office automation [fr

Filtering Dialysis Myths from Facts

Science.gov (United States)

... to work. Fact: Many dialysis patients continue to work, go to school, or volunteer . Some take time off when they first start dialysis treatment and back to work or school after they have gotten used to ...

Tuberculosis Facts - Exposure to TB

Science.gov (United States)

Tuberculosis (TB) Facts Exposure to TB What is TB? “TB” is short for a disease called tuberculosis. TB is spread through the air from one ... Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination

Tuberculosis Facts - Testing for TB

Science.gov (United States)

Tuberculosis (TB) Facts Testing for TB What is TB? “TB” is short for a disease called tuberculosis. TB is spread through the air from one ... Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination

Publication bias and the canonization of false facts

DEFF Research Database (Denmark)

Nissen, Silas Boye; Magidson, Tali; Gross, Kevin

2016-01-01

canonized as fact. Data-dredging, p-hacking, and similar behaviors exacerbate the problem. Should negative results become easier to publish as a claim approaches acceptance as a fact, however, true and false claims would be more readily distinguished. To the degree that the model reflects the real world...

50 Facts about Oral, Head and Neck Cancer

Science.gov (United States)

... Marketplace Find an ENT Doctor Near You 50 Facts about Oral, Head and Neck Cancer 50 Facts about Oral, Head and Neck Cancer Patient Health ... cancer has increased in all races and both sexes. Thyroid cancers account for ... who work in environments with dust, glues, formaldehyde, mustard gas, ...

75 FR 55340 - Recovery Fact Sheet 9580.100, Mold Remediation

Science.gov (United States)

2010-09-10

...] Recovery Fact Sheet 9580.100, Mold Remediation AGENCY: Federal Emergency Management Agency, DHS. ACTION... accepting comments on Recovery Fact Sheet RP9580.100, Mold Remediation. DATES: Comments must be received by... 20472-3100. II. Background The Recovery Fact Sheet RP9580.100, Mold Remediation, identifies the expenses...

Optimal placement of FACTS devices using optimization techniques: A review

Science.gov (United States)

Gaur, Dipesh; Mathew, Lini

2018-03-01

Modern power system is dealt with overloading problem especially transmission network which works on their maximum limit. Today’s power system network tends to become unstable and prone to collapse due to disturbances. Flexible AC Transmission system (FACTS) provides solution to problems like line overloading, voltage stability, losses, power flow etc. FACTS can play important role in improving static and dynamic performance of power system. FACTS devices need high initial investment. Therefore, FACTS location, type and their rating are vital and should be optimized to place in the network for maximum benefit. In this paper, different optimization methods like Particle Swarm Optimization (PSO), Genetic Algorithm (GA) etc. are discussed and compared for optimal location, type and rating of devices. FACTS devices such as Thyristor Controlled Series Compensator (TCSC), Static Var Compensator (SVC) and Static Synchronous Compensator (STATCOM) are considered here. Mentioned FACTS controllers effects on different IEEE bus network parameters like generation cost, active power loss, voltage stability etc. have been analyzed and compared among the devices.

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... 2018 Alzheimer's Disease Facts and Figures report contains data on the impact of this disease in every ... with third parties. Please read our security and privacy policy . Plan ahead Get help and support I ...

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... 272.3900 Donate Alzheimer's & Dementia What Is Alzheimer's? Brain Tour Younger/Early Onset Risk Factors Genetics Myths ... Dementia Korsakoff Syndrome Related Conditions CTE MCI Traumatic Brain Injury Facts and Figures Know the 10 Signs ...

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... Dementia >> Home Text size: A A A 2018 Alzheimer's Disease Facts and Figures Download the full report: ... twice as high. Invest in a world without Alzheimer's. Donate Caregivers Eighty-three percent of the help ...

Altered elementary calcium release events and enhanced calcium release by thymol in rat skeletal muscle.

Science.gov (United States)

Szentesi, Péter; Szappanos, Henrietta; Szegedi, Csaba; Gönczi, Monika; Jona, István; Cseri, Julianna; Kovács, László; Csernoch, László

2004-03-01

The effects of thymol on steps of excitation-contraction coupling were studied on fast-twitch muscles of rodents. Thymol was found to increase the depolarization-induced release of calcium from the sarcoplasmic reticulum, which could not be attributed to a decreased calcium-dependent inactivation of calcium release channels/ryanodine receptors or altered intramembrane charge movement, but rather to a more efficient coupling of depolarization to channel opening. Thymol increased ryanodine binding to heavy sarcoplasmic reticulum vesicles, with a half-activating concentration of 144 micro M and a Hill coefficient of 1.89, and the open probability of the isolated and reconstituted ryanodine receptors, from 0.09 +/- 0.03 to 0.22 +/- 0.04 at 30 micro M. At higher concentrations the drug induced long-lasting open events on a full conducting state. Elementary calcium release events imaged using laser scanning confocal microscopy in the line-scan mode were reduced in size, 0.92 +/- 0.01 vs. 0.70 +/- 0.01, but increased in duration, 56 +/- 1 vs. 79 +/- 1 ms, by 30 micro M thymol, with an increase in the relative proportion of lone embers. Higher concentrations favored long events, resembling embers in control, with duration often exceeding 500 ms. These findings provide direct experimental evidence that the opening of a single release channel will generate an ember, rather than a spark, in mammalian skeletal muscle.

The Development of Reasoning about Beliefs: Fact, Preference, and Ideology.

Science.gov (United States)

Heiphetz, Larisa; Spelke, Elizabeth S; Harris, Paul L; Banaji, Mahzarin R

2013-05-01

The beliefs people hold about the social and physical world are central to self-definition and social interaction. The current research analyzes reasoning about three kinds of beliefs: those that concern matters of fact (e.g., dinosaurs are extinct), preference (e.g., green is the prettiest color), and ideology (e.g., there is only one God). The domain of ideology is of unique interest because it is hypothesized to contain elements of both facts and preferences. If adults' distinct reasoning about ideological beliefs is the result of prolonged experience with the physical and social world, children and adults should reveal distinct patterns of differentiating kinds of beliefs, and this difference should be particularly pronounced with respect to ideological beliefs. On the other hand, if adults' reasoning about beliefs is a basic component of social cognition, children and adults should demonstrate similar belief representations and patterns of belief differentiation. Two experiments demonstrate that 5-10 year old children and adults similarly judged religious beliefs to be intermediate between factual beliefs (where two disagreeing people cannot both be right) and preferences (where they can). From the age of 5 years and continuing into adulthood, individuals distinguished ideological beliefs from other types of mental states and demonstrated limited tolerance for belief-based disagreements.

Chernobyl: the facts

International Nuclear Information System (INIS)

Stanbridge, R.; Dept. of Journalism, Media and Communication Studies)

1993-01-01

In these Search Strategies, searchers from different countries and professions are given a question to answer, a budget of Pounds 50 and a time in which to produce their report. We hope that these blow-by-blow accounts, together with the hints and tips picked up along the way, will help readers to develop their own search strategies. Journalists are more and more coming to use online services and here the author gives a journalist's account of tracking down the elusive facts surrounding the Chernobyl disaster. (author)

Darwinism Defined: The Difference Between Fact and Theory.

Science.gov (United States)

Gould, Stephen Jay

1987-01-01

Discusses various developments in both science and theology following the work of Charles Darwin on evolution. Differentiates between the facts regarding evolution and the theory of natural selection as a mechanism for evolutionary change. Warns that the differences between facts and theory have not been adequately emphasized by scientists. (TW)

On the Ni-Ion release rate from surfaces of binary NiTi shape memory alloys

Science.gov (United States)

Ševčíková, Jana; Bártková, Denisa; Goldbergová, Monika; Kuběnová, Monika; Čermák, Jiří; Frenzel, Jan; Weiser, Adam; Dlouhý, Antonín

2018-01-01

The study is focused on Ni-ion release rates from NiTi surfaces exposed in the cell culture media and human vascular endothelial cell (HUVEC) culture environments. The NiTi surface layers situated in the depth of 70 μm below a NiTi oxide scale are affected by interactions between the NiTi alloys and the bio-environments. The finding was proved with use of inductively coupled plasma mass spectrometry and electron microscopy experiments. As the exclusive factor controlling the Ni-ion release rates was not only thicknesses of the oxide scale, but also the passivation depth, which was two-fold larger. Our experimental data strongly suggested that some other factors, in addition to the Ni concentration in the oxide scale, admittedly hydrogen soaking deep below the oxide scale, must be taken into account in order to rationalize the concentrations of Ni-ions released into the bio-environments. The suggested role of hydrogen as the surface passivation agent is also in line with the fact that the Ni-ion release rates considerably decrease in NiTi samples that were annealed in controlled hydrogen atmospheres prior to bio-environmental exposures.

Notice of release for Eagle Germplasm western yarrow (selected germplasm, natural track)

Science.gov (United States)

Scott M. Lambert; Stephen B. Monsen; Nancy Shaw

2011-01-01

The United States Department of Agriculture, Forest Service, Rocky Mountain Research Station; United States Department of the Interior, Bureau of Land Management, Idaho State Office; Utah State University, Agricultural Experiment Station; and University of Idaho, Agricultural Experiment Station, announce the release of a selected germplasm (natural track) of western...

Desktop 3D printing of controlled release pharmaceutical bilayer tablets.

Science.gov (United States)

Khaled, Shaban A; Burley, Jonathan C; Alexander, Morgan R; Roberts, Clive J

2014-01-30

Three dimensional (3D) printing was used as a novel medicine formulation technique for production of viable tablets capable of satisfying regulatory tests and matching the release of standard commercial tablets. Hydroxypropyl methylcellulose (HPMC 2208) (Methocel™ K100M Premium) and poly(acrylic acid) (PAA) (Carbopol(®) 974P NF) were used as a hydrophilic matrix for a sustained release (SR) layer. Hypromellose(®) (HPMC 2910) was used as a binder while microcrystalline cellulose (MCC) (Pharmacel(®) 102) and sodium starch glycolate (SSG) (Primojel(®)) were used as disintegrants for an immediate release (IR) layer. Commercial guaifenesin bi-layer tablets (GBT) were used as a model drug (Mucinex(®)) for this study. There was a favourable comparison of release of the active guaifenesin from the printed hydrophilic matrix compared with the commercially available GBT. The printed formulations were also evaluated for physical and mechanical properties such as weight variation, friability, hardness and thickness as a comparison to the commercial tablet and were within acceptable range as defined by the international standards stated in the United States Pharmacopoeia (USP). All formulations (standard tablets and 3D printed tablets) showed Korsmeyer-Peppas n values between 0.27 and 0.44 which indicates Fickian diffusion drug release through a hydrated HPMC gel layer. Copyright © 2013 Elsevier B.V. All rights reserved.

Estimation of in-vivo neurotransmitter release by brain microdialysis: the issue of validity.

Science.gov (United States)

Di Chiara, G.; Tanda, G.; Carboni, E.

1996-11-01

Although microdialysis is commonly understood as a method of sampling low molecular weight compounds in the extracellular compartment of tissues, this definition appears insufficient to specifically describe brain microdialysis of neurotransmitters. In fact, transmitter overflow from the brain into dialysates is critically dependent upon the composition of the perfusing Ringer. Therefore, the dialysing Ringer not only recovers the transmitter from the extracellular brain fluid but is a main determinant of its in-vivo release. Two types of brain microdialysis are distinguished: quantitative micro-dialysis and conventional microdialysis. Quantitative microdialysis provides an estimate of neurotransmitter concentrations in the extracellular fluid in contact with the probe. However, this information might poorly reflect the kinetics of neurotransmitter release in vivo. Conventional microdialysis involves perfusion at a constant rate with a transmitter-free Ringer, resulting in the formation of a steep neurotransmitter concentration gradient extending from the Ringer into the extracellular fluid. This artificial gradient might be critical for the ability of conventional microdialysis to detect and resolve phasic changes in neurotransmitter release taking place in the implanted area. On the basis of these characteristics, conventional microdialysis of neurotransmitters can be conceptualized as a model of the in-vivo release of neurotransmitters in the brain. As such, the criteria of face-validity, construct-validity and predictive-validity should be applied to select the most appropriate experimental conditions for estimating neurotransmitter release in specific brain areas in relation to behaviour.

26 CFR 513.7 - Release of excess tax withheld at source.

Science.gov (United States)

2010-04-01

... source from life annuities and pensions, other than pensions paid by the Government of the United States... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Release of excess tax withheld at source. 513.7...) REGULATIONS UNDER TAX CONVENTIONS IRELAND Withholding of Tax § 513.7 Release of excess tax withheld at source...

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... health and long-term care costs. worried about memory loss? KNOW THE 10 SIGNS Alzheimer's Disease Facts ... Copyright © 2018 Alzheimer's Association ® . All rights reserved. Our vision is a world without Alzheimer's Formed in 1980, ...

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... health and long-term care costs. worried about memory loss? KNOW THE 10 SIGNS Alzheimer's Disease Facts ... is a not-for-profit 501(c)(3) organization. Copyright © 2018 Alzheimer's Association ® . All rights reserved. Our ...

FACT. Energy spectrum of the Crab Nebula

Energy Technology Data Exchange (ETDEWEB)

Temme, Fabian; Einecke, Sabrina; Buss, Jens [TU Dortmund, Experimental Physics 5, Otto-Hahn-Str.4, 44221 Dortmund (Germany); Collaboration: FACT-Collaboration

2016-07-01

The First G-APD Cherenkov Telescope is the first Imaging Air Cherenkov Telescope which uses silicon photon detectors (G-APDs aka SiPM) as photo sensors. With more than four years of operation, FACT proved an application of SiPMs is suitable for the field of ground-based gamma-ray astronomy. Due to the stable flux at TeV energies, the Crab Nebula is handled as a ''standard candle'' in Cherenkov astronomy. The analysis of its energy spectrum and comparison with other experiments, allows to evaluate the performance of FACT. A modern analysis chain, based on data stream handling and multivariate analysis methods was developed in close cooperation with the department of computer science at the TU Dortmund. In this talk, this analysis chain and its application are presented. Further to this, results, including the energy spectrum of the Crab Nebula, measured with FACT, are shown.

AutoFACT: An Automatic Functional Annotation and Classification Tool

Directory of Open Access Journals (Sweden)

Lang B Franz

2005-06-01

Full Text Available Abstract Background Assignment of function to new molecular sequence data is an essential step in genomics projects. The usual process involves similarity searches of a given sequence against one or more databases, an arduous process for large datasets. Results We present AutoFACT, a fully automated and customizable annotation tool that assigns biologically informative functions to a sequence. Key features of this tool are that it (1 analyzes nucleotide and protein sequence data; (2 determines the most informative functional description by combining multiple BLAST reports from several user-selected databases; (3 assigns putative metabolic pathways, functional classes, enzyme classes, GeneOntology terms and locus names; and (4 generates output in HTML, text and GFF formats for the user's convenience. We have compared AutoFACT to four well-established annotation pipelines. The error rate of functional annotation is estimated to be only between 1–2%. Comparison of AutoFACT to the traditional top-BLAST-hit annotation method shows that our procedure increases the number of functionally informative annotations by approximately 50%. Conclusion AutoFACT will serve as a useful annotation tool for smaller sequencing groups lacking dedicated bioinformatics staff. It is implemented in PERL and runs on LINUX/UNIX platforms. AutoFACT is available at http://megasun.bch.umontreal.ca/Software/AutoFACT.htm.

Facts about Tetralogy of Fallot

Science.gov (United States)

... Websites Information For… Media Policy Makers Facts about Tetralogy of Fallot Language: English (US) Español (Spanish) Recommend on Facebook ... in the mother’s womb during pregnancy. What is Tetralogy of Fallot? Tetralogy of Fallot is made up of the ...

State of Art About water Uses and Waste water Management in Lebanon

International Nuclear Information System (INIS)

Geara, D.; Moilleron, R.; Lorgeoux, C.; El Samarani, A.; Chebbo, Gh.

2010-01-01

This paper shows the real situation about management of water and waste water in Lebanon and focuses on problems related to urban water pollution released in environment. Water and waste water infrastructures have been rebuilt since 1992. However, waste water management still remains one of the greatest challenges facing Lebanese people, since water supply projects have been given priority over wastewater projects. As a consequence of an increased demand of water by agricultural, industrial and household sectors in the last decade, waste water flows have been increased. In this paper, the existing waste water treatment plants (WWTP) operating in Lebanon are presented. Most of them are small-scale community-based ones, only two large-scale plants, constructed by the government, are currently operational. Lebanese aquatic ecosystems are suffering from the deterioration of water quality because of an insufficient treatment of waste water, which is limited mostly to pre-treatment processes. In fact, domestic and industrial effluents are mainly conducted together in the sewer pipes to the WWTP before being discharged, without adequate treatment into the rivers or directly into the Mediterranean Sea. Such discharges are threatening the coastal marine ecosystem in the Mediterranean basin. This paper aims at giving the current state of knowledge about water uses and wastewater management in Lebanon. The main conclusion drawn from this state of art is a lack of data. In fact, the available data are limited to academic research without being representative on a national scale. (author)

Reporting continuous releases of hazardous and extremely hazardous substances under CERCLA and EPCRA

International Nuclear Information System (INIS)

1995-01-01

This guidance is designed to provide basic instruction to US DOE and DOE operations contractor personnel on how to characterize CERCLA and EPCRA hazardous substance releases as continuous and how to prepare and deliver continuousreleasee reports to Federal, State, and local authorities. DOE staff should use this guidance as an overview of the continuous release requirements, a quick ready reference guide for specific topics concerning continuous releases and a step-by-step guide for the process of identifying and reporting continuous releases

Hanford Tanks 241-C-203 and 241-C-204: Residual Waste Contaminant Release Model and Supporting Data

Energy Technology Data Exchange (ETDEWEB)

Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.; Cantrell, Kirk J.; Brown, Christopher F.; Schaef, Herbert T.

2004-10-28

This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.

Hanford Tanks 241-C-203 and 241-C-204: Residual Waste Contaminant Release Model and Supporting Data

International Nuclear Information System (INIS)

Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.; Cantrell, Kirk J.; Brown, Christopher F.; Schaef, Herbert T.

2004-01-01

This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy

Related Fact Checks: a tool for combating fake news

OpenAIRE

Guha, Sreya

2017-01-01

The emergence of "Fake News" and misinformation via online news and social media has spurred an interest in computational tools to combat this phenomenon. In this paper we present a new "Related Fact Checks" service, which can help a reader critically evaluate an article and make a judgment on its veracity by bringing up fact checks that are relevant to the article. We describe the core technical problems that need to be solved in building a "Related Fact Checks" service, and present results ...

Rapid release of 42K and 86Rb from an occluded state of the Na,K-pump in the presence of ATP or ADP

International Nuclear Information System (INIS)

Forbush, B. III

1987-01-01

We have measured the time course of release of 42 K and 86 Rb from an occluded state of the Na,K-pump using a rapid filtration apparatus. We have found that at 20 degrees C and in the presence of ATP, 42 K is released with a rate constant of approximately 45 s-1 and 86 Rb with a rate constant of approximately 20 s-1; both ATP and ADP are effective at a low affinity site (Kd approximately 0.3 and 1 mM, respectively) with the rate of deocclusion being only half as great in ADP as in ATP. Mg2+ stimulates 2-fold at low concentrations probably by forming MgATP, and free Mg2+ is strongly inhibitory at high concentrations (Kd approximately 10 mM). Mg2+ also decreases the affinity for ATP, and the data are consistent with mixed type inhibition; from the analysis the dissociation constant is approximately 1 mM for the inhibitory Mg2+ and the Rb+-occluded form without ATP. The rate of 42 K or 86 Rb release increases monotonically with pH while ATPase activity decreases above pH 8, so that deocclusion is not rate-limiting in the overall cycle at high pH. This is reflected by a convergence of the rate of Na,K-ATPase and Na,Rb-ATPase activities at high pH and by a decrease in the observed steady-state level of the occluded 86 Rb intermediate at high pH. K+, Rb+, Na+, and Cs+, but not Li+, increase the rate of 42 K and 86 Rb release at constant ionic strength, presumably at sites other than the transport sites. The spontaneous rate of deocclusion is only approximately 0.1 s-1 at low ionic strength in the absence of nucleotides, and it is increased markedly by all cations tested except Li+. Overall the data are consistent with deocclusion as a rate-limiting step in the Na,K-pump cycle

Modelling the release behaviour of cesium during severe fuel degradation

International Nuclear Information System (INIS)

Lewis, B.J.; Andre, B.; Morel, B.

1995-01-01

An analytical model has been applied to describe the diffusional release of fission product cesium from Zircaloy-clad fuel under high-temperature reactor accident conditions. The present treatment accounts for the influence of the atmosphere (i.e., changing oxygen potential) on the state of fuel oxidation and the release kinetics. The effects of fuel dissolution on the volatile release behaviour (under reducing conditions) is considered in terms of earlier crucible experiments and a simple model based on bubble coalescence and transport in metal pools. The model has been used to interpret the cesium release kinetics observed in steam and hydrogen experiments at the Vertical Irradiation (VI) Facility in the Oak Ridge National Laboratory and at the HEVA/VERCORS Facility in the Commissariat a l'Energie Atomique. (author)

Myths and Facts about SIDS and Safe Infant Sleep

Science.gov (United States)

... Myths and Facts About SIDS and Safe Infant Sleep Page Content Myth: Babies can “catch” SIDS. Fact: ... sleep environment for your baby. Myth: Babies who sleep on their backs will choke if they spit ...

MIT Lincoln Laboratory Facts 2013

Science.gov (United States)

2012-12-01

creativity . Representative Technical Positions ■■ Aerospace engineer ■■ Applications engineer ■■ Bioengineer ■■ Biologist 16 Facts 2012–2013...schedules, part-time employment, and telecommuting opportunities. Child Care The Technology Children’s Center facility in Lexington (TCC Lincoln

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... and support I have Alzheimer's I am a caregiver I am a care professional I am a physician I am a researcher Message boards Get the facts 10 warning signs & symptoms What is dementia What is Alzheimer's 7 stages of ...

Modified thermoresponsive Poloxamer 407 and chitosan sol-gels as potential sustained-release vaccine delivery systems.

Science.gov (United States)

Kojarunchitt, Thunjiradasiree; Baldursdottir, Stefania; Dong, Yao-Da; Boyd, Ben J; Rades, Thomas; Hook, Sarah

2015-01-01

Thermoresponsive, particle-loaded, Poloxamer 407 (P407)-Pluronic-R® (25R4) or chitosan-methyl cellulose (MC) formulations were developed as single-dose, sustained release vaccines. The sol-gels, loaded either with a particulate vaccine (cubosomes) or soluble antigen (ovalbumin) and adjuvants (Quil A and monophosphoryl lipid A), were free-flowing liquids at room temperature and formed stable gels at physiological temperatures. Rheological results showed that both systems meet the criteria of being thermoresponsive gels. The P407-25R4 sol-gels did not significantly sustain the release of antigen in vivo while the chitosan-MC sol-gels sustained the release of antigen up to at least 14 days after administration. The chitosan-MC sol-gels stimulated both cellular and humoral responses. The inclusion of cubosomes in the sol-gels did not provide a definitive beneficial effect. Further analysis of the formulations with small-angle X-ray scattering (SAXS) revealed that while cubosomes were stable in chitosan-MC gels they were not stable in P407-25R4 formulations. The reason for the mixed response to cubosome-loaded vehicles requires more investigation, however it appears that the cubosomes did not facilitate synchronous vaccine release and may in fact retard release, reducing efficacy in some cases. From these results, chitosan-MC sol-gels show potential as sustained release vaccine delivery systems, as compared to the P407-25R4 system that had a limited ability to sustain antigen release. Copyright © 2014 Elsevier B.V. All rights reserved.

A novel symbiotic organisms search algorithm for optimal power flow of power system with FACTS devices

Directory of Open Access Journals (Sweden)

Dharmbir Prasad

2016-03-01

Full Text Available In this paper, symbiotic organisms search (SOS algorithm is proposed for the solution of optimal power flow (OPF problem of power system equipped with flexible ac transmission systems (FACTS devices. Inspired by interaction between organisms in ecosystem, SOS algorithm is a recent population based algorithm which does not require any algorithm specific control parameters unlike other algorithms. The performance of the proposed SOS algorithm is tested on the modified IEEE-30 bus and IEEE-57 bus test systems incorporating two types of FACTS devices, namely, thyristor controlled series capacitor and thyristor controlled phase shifter at fixed locations. The OPF problem of the present work is formulated with four different objective functions viz. (a fuel cost minimization, (b transmission active power loss minimization, (c emission reduction and (d minimization of combined economic and environmental cost. The simulation results exhibit the potential of the proposed SOS algorithm and demonstrate its effectiveness for solving the OPF problem of power system incorporating FACTS devices over the other evolutionary optimization techniques that surfaced in the recent state-of-the-art literature.

On the consequences of the fact that atomic levels have a certain width

OpenAIRE

Billionnet, Claude

2009-01-01

This note presents two ideas. The first one is that quantum theory has a fundamentally perturbative basis but leads to nonperturbative states which it would seem natural to take into account in the foundation of a theory of quantum phenomena. The second one consists in questioning the validity of the present notion of time. Both matters are related to the fact that atomic levels have a certain width. This note is presented qualitatively so as to evidence its main points, independently of the ...

FACT — LONGTERM MONITORING OF BRIGHT TeV BLAZARS

Directory of Open Access Journals (Sweden)

Katja Meier

2014-06-01

Full Text Available The First G-APD Cherenkov Telescope (FACT, located on the Canary Island of La Palma, has been taking data since October 2011. FACT has been optimized for longterm monitoring of bright TeV blazars, to study their variability time scales and flare probability. G-APD photo-sensors allow for observations even under strong moonlight conditions, and the telescope can be operated remotely. The monitoring strategy of FACT is discussed and preliminary results of the flare of Mrk501 in June 2012 are shown.

Clean Cities Fact Sheet

Energy Technology Data Exchange (ETDEWEB)

2004-01-01

This fact sheet explains the Clean Cities Program and provides contact information for all coalitions and regional offices. It answers key questions such as: What is the Clean Cities Program? What are alternative fuels? How does the Clean Cities Program work? What sort of assistance does Clean Cities offer? What has Clean Cities accomplished? What is Clean Cities International? and Where can I find more information?

Considering FACTS in Optimal Transmission Expansion Planning

Directory of Open Access Journals (Sweden)

K. Soleimani

2017-10-01

Full Text Available The expansion of power transmission systems is an important part of the expansion of power systems that requires enormous investment costs. Since the construction of new transmission lines is very expensive, it is necessary to choose the most efficient expansion plan that ensures system security with a minimal number of new lines. In this paper, the role of Flexible AC Transmission System (FACTS devices in the effective operation and expansion planning of transmission systems is examined. Effort was taken to implement a method based on sensitivity analysis to select the optimal number and location of FACTS devices, lines and other elements of the transmission system. Using this method, the transmission expansion plan for a 9 and a 39 bus power system was performed with and without the presence of FACTS with the use of DPL environment in Digsilent software 15.1. Results show that the use of these devices reduces the need for new transmission lines and minimizes the investment cost.

Bioavailability and stability of erythromycin delayed release tablets.

Science.gov (United States)

Ogwal, S; Xide, T U

2001-12-01

Erythromycin is available as the free base, ethylsuccinate, estolate, stearate, gluceptate, and lactobionate derivatives. When given orally erythromycin and its derivatives except the estolate are inactivated to some extent by the gastric acid and poor absorption may result. To establish whether delayed release erythromycin tablets meet the bioequivalent requirement for the market. Sectrophotometric analysis was used to determine the dissolution percentage of the tablets in vitro. High performance liquid chromatography and IBM/XT microcomputer was used to determine the bioavailability and pharmacokinetic parameters in vivo. Dissolution percentage in thirty minutes reached 28.9% and in sixty minutes erythromycin was completely released. The parameters of the delayed release tablets were Tlag 2.3 hr, Tmax.4.5 hr, and Cmax 2.123 g/ml Ka 0.38048 hr(-1) T (1/2) 1.8 hr, V*C/F 49.721 AUC 12.9155. The relative bioavailability of erythromycin delayed release tablet to erythromycin capsules was 105.31% The content, appearance, and dissolution bioavailability of delayed release erythromycin tablets conforms to the United States pharmacopoeia standards. The tablets should be stored in a cool and dry place in airtight containers and the shelf life is temporarily assigned two years.

Fission gas release from oxide fuels at high burnups (AWBA development program)

International Nuclear Information System (INIS)

Dollins, C.C.

1981-02-01

The steady state gas release, swelling and densification model previously developed for oxide fuels has been modified to accommodate the slow transients in temperature, temperature gradient, fission rate and pressure that are encountered in normal reactor operation. The gas release predictions made by the model were then compared to gas release data on LMFBR-EBRII fuels obtained by Dutt and Baker and reported by Meyer, Beyer, and Voglewede. Good agreement between the model and the data was found. A comparison between the model and three other sets of gas release data is also shown, again with good agreement

International Nuclear Fuel Cycle Fact Book

International Nuclear Information System (INIS)

Leigh, I.W.

1992-05-01

As the US Department of Energy (DOE) and DOE contractors have become increasingly involved with other nations in nuclear fuel cycle and waste management cooperative activities, a need exists costs for a ready source of information concerning foreign fuel cycle programs, facilities, and personnel. This Fact Book has been compiled to meet that need. The information contained in the International Nuclear Fuel Cycle Fact Book has been obtained from many unclassified sources: nuclear trade journals and newsletters; reports of foreign visits and visitors; CEC, IAEA, and OECD/NMEA activities reports; and proceedings of conferences and workshops. The data listed typically do not reflect any single source but frequently represent a consolidation/combination of information

International Nuclear Fuel Cycle Fact Book

International Nuclear Information System (INIS)

Leigh, I.W.; Mitchell, S.J.

1990-01-01

As the US Department of Energy (DOE) and DOE contractors have become increasingly involved with other nations in nuclear fuel cycle and waste management cooperative activities, a need has developed for a ready source of information concerning foreign fuel cycle programs, facilities, and personnel. This Fact Book was compiled to meet that need. The information contained in the International Nuclear Fuel Cycle Fact Book has been obtained from many unclassified sources: nuclear trade journals and newsletters; reports of foreign visits and visitors; CEC, IAEA, and OECD/NEA activities reports; proceedings of conferences and workshops, etc. The data listed do not reflect any one single source but frequently represent a consolidation/combination of information

International Nuclear Fuel Cycle Fact Book

Energy Technology Data Exchange (ETDEWEB)

Leigh, I W; Mitchell, S J

1990-01-01

As the US Department of Energy (DOE) and DOE contractors have become increasingly involved with other nations in nuclear fuel cycle and waste management cooperative activities, a need has developed for a ready source of information concerning foreign fuel cycle programs, facilities, and personnel. This Fact Book was compiled to meet that need. The information contained in the International Nuclear Fuel Cycle Fact Book has been obtained from many unclassified sources: nuclear trade journals and newsletters; reports of foreign visits and visitors; CEC, IAEA, and OECD/NEA activities reports; proceedings of conferences and workshops, etc. The data listed do not reflect any one single source but frequently represent a consolidation/combination of information.

Norms and facts in measurement

NARCIS (Netherlands)

Brakel, J. van

1984-01-01

Publications concerned with the foundations of measurement often accept uncritically the theory/observation and the norm/fact distinction. However, measurement is measurement-in-a-context. This is analysed in the first part of the paper. Important aspects of this context are: the purpose of the

Globalization and the Nation-State: Sovereignty and State Welfare in Jeopardy

Science.gov (United States)

Jotia, Agreement Lathi

2011-01-01

This paper addresses the fact that although globalization cannot be resisted by the nation-state, it is often confronted by mixed reactions from both the GN (Global North) and the GS (Global South). The essay charges that globalization has political, economic and cultural impact on the nation-state, which ultimately impacts the issue of identity…

Kinetics of corrosion products release from nickel-base alloys corroding in primary water conditions. A new modeling of release

International Nuclear Information System (INIS)

Carrette, F.; Guinard, L.; Pieraggi, B.

2002-01-01

The radioactivity in the primary circuit arises mainly from the activation of corrosion products in the core of pressurised water reactors; corrosion products dissolve from the oxide scales developed on steam generator tubes of alloy 690. The controlling and modelling of this process require a detailed knowledge of the microstructure and chemical composition of oxide scales as well as the kinetics of their corrosion and dissolution. Alloy 690 was studied as tubes and sheets, with three various surface states (as-received, cold-worked, electropolished). Corrosion tests were performed at 325 C and 155 bar in primary water conditions (B/Li - 1000/2 ppm, [H 2 ] 30 cm 3 .kg -1 TPN, [O 2 ] < 5 ppb); test durations ranged between 24 and 2160 hours. Corrosion tests in the TITANE loop provided mainly corrosion and oxidation kinetics, and tests in the BOREAL loop yielded release kinetics. This study revealed asymptotic type kinetics. Characterisation of the oxide scales grown in representative conditions of the primary circuit was performed by several techniques (SEM, TEM, SIMS, XPS, GIXRD). These analyses revealed the essential role of the fine grained cold-worked scale present on as-received and cold-worked materials. This scale controls the corrosion and release phenomena. The kinetic study and the characterisation of the oxide scales contributed to the modelling of the corrosion/release process. A growth/dissolution model was proposed for corrosion product scales grown in non-saturated dynamic fluid. This model provided the temporal evolution of oxide scales and release kinetics for different species (Fe, Ni, Cr). The model was validated for several surface states and several alloys. (authors)

Autism: General Information. Fact Sheet Number 1 = Autismo: Informacion General. Fact Sheet Number 22.

Science.gov (United States)

Interstate Research Associates, McLean, VA.

This fact sheet on autism is offered in both English and Spanish, and is the same in both languages although numbered differently. It provides a definition, information on incidence, typical characteristics, and educational implications. It notes that autism is listed as a separate category under the Individuals with Disabilities Education Act.…

Fact or factitious? A psychobiological study of authentic and simulated dissociative identity states.

Science.gov (United States)

Reinders, A A T S; Reinders, A A T Simone; Willemsen, Antoon T M; Vos, Herry P J; den Boer, Johan A; Nijenhuis, Ellert R S

2012-01-01

Dissociative identity disorder (DID) is a disputed psychiatric disorder. Research findings and clinical observations suggest that DID involves an authentic mental disorder related to factors such as traumatization and disrupted attachment. A competing view indicates that DID is due to fantasy proneness, suggestibility, suggestion, and role-playing. Here we examine whether dissociative identity state-dependent psychobiological features in DID can be induced in high or low fantasy prone individuals by instructed and motivated role-playing, and suggestion. DID patients, high fantasy prone and low fantasy prone controls were studied in two different types of identity states (neutral and trauma-related) in an autobiographical memory script-driven (neutral or trauma-related) imagery paradigm. The controls were instructed to enact the two DID identity states. Twenty-nine subjects participated in the study: 11 patients with DID, 10 high fantasy prone DID simulating controls, and 8 low fantasy prone DID simulating controls. Autonomic and subjective reactions were obtained. Differences in psychophysiological and neural activation patterns were found between the DID patients and both high and low fantasy prone controls. That is, the identity states in DID were not convincingly enacted by DID simulating controls. Thus, important differences regarding regional cerebral bloodflow and psychophysiological responses for different types of identity states in patients with DID were upheld after controlling for DID simulation. The findings are at odds with the idea that differences among different types of dissociative identity states in DID can be explained by high fantasy proneness, motivated role-enactment, and suggestion. They indicate that DID does not have a sociocultural (e.g., iatrogenic) origin.

Release Early, Release Often: Predicting Change in Versioned Knowledge Organization Systems on the Web

OpenAIRE

Meroño-Peñuela, Albert; Guéret, Christophe; Schlobach, Stefan

2015-01-01

The Semantic Web is built on top of Knowledge Organization Systems (KOS) (vocabularies, ontologies, concept schemes) that provide a structured, interoperable and distributed access to Linked Data on the Web. The maintenance of these KOS over time has produced a number of KOS version chains: subsequent unique version identifiers to unique states of a KOS. However, the release of new KOS versions pose challenges to both KOS publishers and users. For publishers, updating a KOS is a knowledge int...

Facts about Type 2

Medline Plus

Full Text Available ... About Us Who We Are Careers Contact Us Policies Corporate Support Newsroom Press Releases For Professionals En Español Online Community Walk Bike Shop Sign in American Diabetes Association ...

Controlled release of ibuprofen by meso–macroporous silica

Energy Technology Data Exchange (ETDEWEB)

Santamaría, E., E-mail: esthersantamaria@ub.edu; Maestro, A.; Porras, M.; Gutiérrez, J.M.; González, C.

2014-02-15

Structured meso–macroporous silica was successfully synthesized from an O/W emulsion using decane as a dispersed phase. Sodium silicate solution, which acts as a silica source and a poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (EO{sub 19}PO{sub 39}EO{sub 19}) denoted as P84 was used in order to stabilize the emulsion and as a mesopore template. The materials obtained were characterized through transmission electron microscopy (TEM), scanning electron microscopy (SEM), small-angle X-ray diffraction scattering (SAXS) and nitrogen adsorption–desorption isotherms. Ibuprofen (IBU) was selected as the model drug and loaded into ordered meso–macroporous materials. The effect of the materials’ properties on IBU drug loading and release was studied. The results showed that the loading of IBU increases as the macropore presence in the material is increased. The IBU adsorption process followed the Langmuir adsorption isotherm. A two-step release process, consisting of an initial fast release and then a slower release was observed. Macropores enhanced the adsorption capacity of the material; this was probably due to the fact that they allowed the drug to access internal pores. When only mesopores were present, ibuprofen was probably adsorbed on the mesopores close to the surface. Moreover, the more macropore present in the material, the slower the release behaviour observed, as the ibuprofen adsorbed in the internal pores had to diffuse along the macropore channels up to the surface of the material. The material obtained from a highly concentrated emulsion was functionalized with amino groups using two methods, the post-grafting mechanism and the co-condensation mechanism. Both routes improve IBU adsorption in the material and show good behaviour as a controlled drug delivery system. - Graphical abstract: Ibuprofen release profiles for the materials obtained from samples P84{sub m}eso (black diamonds), P84{sub 2}0% (white squares), P84{sub 5

Controlled release of ibuprofen by meso–macroporous silica

International Nuclear Information System (INIS)

Santamaría, E.; Maestro, A.; Porras, M.; Gutiérrez, J.M.; González, C.

2014-01-01

Structured meso–macroporous silica was successfully synthesized from an O/W emulsion using decane as a dispersed phase. Sodium silicate solution, which acts as a silica source and a poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (EO 19 PO 39 EO 19 ) denoted as P84 was used in order to stabilize the emulsion and as a mesopore template. The materials obtained were characterized through transmission electron microscopy (TEM), scanning electron microscopy (SEM), small-angle X-ray diffraction scattering (SAXS) and nitrogen adsorption–desorption isotherms. Ibuprofen (IBU) was selected as the model drug and loaded into ordered meso–macroporous materials. The effect of the materials’ properties on IBU drug loading and release was studied. The results showed that the loading of IBU increases as the macropore presence in the material is increased. The IBU adsorption process followed the Langmuir adsorption isotherm. A two-step release process, consisting of an initial fast release and then a slower release was observed. Macropores enhanced the adsorption capacity of the material; this was probably due to the fact that they allowed the drug to access internal pores. When only mesopores were present, ibuprofen was probably adsorbed on the mesopores close to the surface. Moreover, the more macropore present in the material, the slower the release behaviour observed, as the ibuprofen adsorbed in the internal pores had to diffuse along the macropore channels up to the surface of the material. The material obtained from a highly concentrated emulsion was functionalized with amino groups using two methods, the post-grafting mechanism and the co-condensation mechanism. Both routes improve IBU adsorption in the material and show good behaviour as a controlled drug delivery system. - Graphical abstract: Ibuprofen release profiles for the materials obtained from samples P84 m eso (black diamonds), P84 2 0% (white squares), P84 5 0% (black triangles), P84 7

Social constructivism and positive epistemology: On establishing of scientific facts

Directory of Open Access Journals (Sweden)

Brdar Milan

2009-01-01

Full Text Available In this article author is dealing with the problem of genesis and establishing of scientific fact. In the first part is given philosophical treatment of the problem and its futility, for the reason given in Minhausen trilema as a conclusion of this kind of treatment. Second part of the article contains the review of Ludvik Fleck's positive epistemology and of social constructivism. After the short historical review of the roots of social constructivism in the Mannheim's sociology of knowledge, author describes how it goes with erstablishing of scientific fact. Solution is set forth by elaboration of triad physis-nomos-logos within the constitutive elements of society known as authority-institution-reason-discourse. Author's concluding thesis claims that there is no fact without convention, i.e. that nature and scientific fact are connected by institution (scientific or social. It does not mean that there is no sound established facts but that obstacle toward it is provided just with institutional mediation that make condition of possibility of very truth. Therefore, the question: what among known facts are really truthful amounts to eternal problem of science and common sense in every epoch of history. .

Alzheimer's Disease Facts and Figures

Medline Plus

Full Text Available ... get Alzheimer's disease were diagnosed in the mild cognitive impairment (MCI) stage — before dementia — it would collectively save $7 trillion to $7.9 trillion in health and long-term care costs. worried about memory loss? KNOW THE 10 SIGNS Alzheimer's Disease Facts ...

Facts about Infectious Diseases (ID)

Science.gov (United States)

... an ID Specialist? Facts about ID Pocketcard Infectious diseases are caused by microscopic organisms that penetrate the body’s natural ... from diseases such as AIDS or treatment of diseases such as cancer, may allow ... of contaminated food or water, bites from vectors such as ticks or mosquitoes ...

Fact Sheet on Women of Spanish Origin in the United States.

Science.gov (United States)

Employment Standards Administration (DOL), Washington, DC. Women's Bureau.

March 1971 data are given for women of Spanish origin in the United States. Country of origin, population, family composition, educational attainment, labor force participation, type of work, income, and low income level are covered. Where separate data for women are not available, data for both sexes are shown. (KM)

Preparation of mesoporous silica microparticles by sol-gel/emulsion route for protein release.

Science.gov (United States)

Vlasenkova, Mariya I; Dolinina, Ekaterina S; Parfenyuk, Elena V

2018-04-06

Encapsulation of therapeutic proteins into particles from appropriate material can improve both stability and delivery of the drugs, and the obtained particles can serve as a platform for development of their new oral formulations. The main goal of this work was development of sol-gel/emulsion method for preparation of silica microcapsules capable of controlled release of encapsulated protein without loss of its native structure. For this purpose, the reported in literature direct sol-gel/W/O/W emulsion method of protein encapsulation was used with some modifications, because the original method did not allow to prepare silica microcapsules capable for protein release. The particles were synthesized using sodium silicate and tetraethoxysilane as silica precursors and different compositions of oil phase. In vitro kinetics of bovine serum albumin (BSA) release in buffer (pH 7.4) was studied by Fourier transform infrared (FTIR) and fluorescence spectrometry, respectively. Structural state of encapsulated BSA and after release was evaluated. It was found that the synthesis conditions influenced substantially the porous structure of the unloaded silica particles, release properties of the BSA-loaded silica particles and structural state of the encapsulated and released protein. The modified synthesis conditions made it possible to obtain the silica particles capable of controlled release of the protein during a week without loss of the protein native structure.

Steady-State Flammable Gas Release Rate Calculation And Lower Flammability Level Evaluation For Hanford Tank Waste

International Nuclear Information System (INIS)

Meacham, J.E.

2008-01-01

This report assesses the steady state flammability level under off normal ventilation conditions in the tank headspace for 28 double-shell tanks (DST) and 149 single shell-tanks (SST) at the Hanford Site. Flammability was calculated using estimated gas release rates, Le Chatelier's rule, and lower flammability limits of fuels in an air mixture. This revision updates the hydrogen generation rate input data for al1 177 tanks using waste composition information from the Best Basis Inventory Detail Report (data effective as of August 4,2008). Assuming only barometric breathing, the shortest time to reach 25% of the lower flammability limit is 13 days for DSTs (i.e., tank 241-AZ-102) and 36 days for SSTs (i.e., tank 241-B-203). Assuming zero ventilation, the shortest time to reach 25% of the lower flammability limit is 12 days for DSTs (i.e., tank 241-AZ-102) and 34 days for SSTs (i.e., tank 241-B-203).

Steady-State Flammable Gas Release Rate Calculation And Lower Flammability Level Evaluation For Hanford Tank Waste

International Nuclear Information System (INIS)

Meacham, J.E.

2009-01-01

This report assesses the steady state flammability level under off normal ventilation conditions in the tank headspace for 28 double-shell tanks (DST) and 149 single shell-tanks (SST) at the Hanford Site. Flammability was calculated using estimated gas release rates, Le Chatelier's rule, and lower flammability limits of fuels in an air mixture. This revision updates the hydrogen generation rate input data for all 177 tanks using waste composition information from the Best Basis Inventory Detail Report (data effective as of August 4,2008). Assuming only barometric breathing, the shortest time to reach 25% of the lower flammability limit is 11 days for DSTs (i.e., tank 241-AZ-10l) and 36 days for SSTs (i.e., tank 241-B-203). Assuming zero ventilation, the shortest time to reach 25% of the lower flammability limit is 10 days for DSTs (i.e., tank 241-AZ-101) and 34 days for SSTs (i.e., tank 241-B-203).

Fact or factitious? A psychobiological study of authentic and simulated dissociative identity states.

Directory of Open Access Journals (Sweden)

A A T S Reinders

Full Text Available BACKGROUND: Dissociative identity disorder (DID is a disputed psychiatric disorder. Research findings and clinical observations suggest that DID involves an authentic mental disorder related to factors such as traumatization and disrupted attachment. A competing view indicates that DID is due to fantasy proneness, suggestibility, suggestion, and role-playing. Here we examine whether dissociative identity state-dependent psychobiological features in DID can be induced in high or low fantasy prone individuals by instructed and motivated role-playing, and suggestion. METHODOLOGY/PRINCIPAL FINDINGS: DID patients, high fantasy prone and low fantasy prone controls were studied in two different types of identity states (neutral and trauma-related in an autobiographical memory script-driven (neutral or trauma-related imagery paradigm. The controls were instructed to enact the two DID identity states. Twenty-nine subjects participated in the study: 11 patients with DID, 10 high fantasy prone DID simulating controls, and 8 low fantasy prone DID simulating controls. Autonomic and subjective reactions were obtained. Differences in psychophysiological and neural activation patterns were found between the DID patients and both high and low fantasy prone controls. That is, the identity states in DID were not convincingly enacted by DID simulating controls. Thus, important differences regarding regional cerebral bloodflow and psychophysiological responses for different types of identity states in patients with DID were upheld after controlling for DID simulation. CONCLUSIONS/SIGNIFICANCE: The findings are at odds with the idea that differences among different types of dissociative identity states in DID can be explained by high fantasy proneness, motivated role-enactment, and suggestion. They indicate that DID does not have a sociocultural (e.g., iatrogenic origin.

Fact or Factitious? A Psychobiological Study of Authentic and Simulated Dissociative Identity States

Science.gov (United States)

Simone Reinders, A. A. T.; Willemsen, Antoon T. M.; Vos, Herry P. J.; den Boer, Johan A.; Nijenhuis, Ellert R. S.

2012-01-01

Background Dissociative identity disorder (DID) is a disputed psychiatric disorder. Research findings and clinical observations suggest that DID involves an authentic mental disorder related to factors such as traumatization and disrupted attachment. A competing view indicates that DID is due to fantasy proneness, suggestibility, suggestion, and role-playing. Here we examine whether dissociative identity state-dependent psychobiological features in DID can be induced in high or low fantasy prone individuals by instructed and motivated role-playing, and suggestion. Methodology/Principal Findings DID patients, high fantasy prone and low fantasy prone controls were studied in two different types of identity states (neutral and trauma-related) in an autobiographical memory script-driven (neutral or trauma-related) imagery paradigm. The controls were instructed to enact the two DID identity states. Twenty-nine subjects participated in the study: 11 patients with DID, 10 high fantasy prone DID simulating controls, and 8 low fantasy prone DID simulating controls. Autonomic and subjective reactions were obtained. Differences in psychophysiological and neural activation patterns were found between the DID patients and both high and low fantasy prone controls. That is, the identity states in DID were not convincingly enacted by DID simulating controls. Thus, important differences regarding regional cerebral bloodflow and psychophysiological responses for different types of identity states in patients with DID were upheld after controlling for DID simulation. Conclusions/Significance The findings are at odds with the idea that differences among different types of dissociative identity states in DID can be explained by high fantasy proneness, motivated role-enactment, and suggestion. They indicate that DID does not have a sociocultural (e.g., iatrogenic) origin. PMID:22768068

Quinoidal Oligo(9,10-anthryl)s with Chain-Length-Dependent Ground States: A Balance between Aromatic Stabilization and Steric Strain Release

KAUST Repository

Lim, Zhenglong

2015-11-12

Quinoidal π-conjugated polycyclic hydrocarbons have attracted intensive research interest due to their unique optical/electronic properties and possible magnetic activity, which arises from a thermally excited triplet state. However, there is still lack of fundamental understanding on the factors that determine the electronic ground states. Herein, by using quinoidal oligo(9,10-anthryl)s, it is demonstrated that both aromatic stabilisation and steric strain release play balanced roles in determining the ground states. Oligomers with up to four anthryl units were synthesised and their ground states were investigated by electronic absorption and electron spin resonance (ESR) spectroscopy, assisted by density functional theory (DFT) calculations. The quinoidal 9,10-anthryl dimer 1 has a closed-shell ground state, whereas the tri- (2) and tetramers (3) both have an open-shell diradical ground state with a small singlet-triplet gap. Such a difference results from competition between two driving forces: the large steric repulsion between the anthryl/phenyl units in the closed-shell quinoidal form that drives the molecule to a flexible open-shell diradical structure, and aromatic stabilisation due to the gain of more aromatic sextet rings in the closed-shell form, which drives the molecule towards a contorted quinoidal structure. The ground states of these oligomers thus depend on the overall balance between these two driving forces and show chain-length dependence. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Youth Volunteering in the States: 2002 and 2003. CIRCLE Fact Sheet.

Science.gov (United States)

Helms, Sara E.

2004-01-01

Volunteer rates vary tremendously across states and age groups. In recent years, young people have exhibited rising volunteering rates, particularly high school students and college freshmen. When comparing the volunteer rates for different age groups in 2002 and 2003, 16-18 year olds volunteer at consistently higher rates than their college-age…

75 FR 24740 - Recovery Fact Sheet RP9580.102, Permanent Relocation

Science.gov (United States)

2010-05-05

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2010-0028] Recovery Fact Sheet RP9580.102, Permanent Relocation AGENCY: Federal Emergency Management Agency, DHS... Management Agency (FEMA). DATES: This fact sheet is effective April 14, 2010. ADDRESSES: This final fact...

Visitor, State of Alaska

Science.gov (United States)

/Fishing License Get a Birth Certificate, Marriage License, etc. Alaska Permanent Fund Dividend Statewide Library Alaska Historical Society Alaska State Museum Sheldon Jackson Museum Industry Facts Agriculture

Reductive Alkaline Release of N-Glycans Generates a Variety of Unexpected, Useful Products.

Science.gov (United States)

Figl, Rudolf; Altmann, Friedrich

2018-02-01

Release of O-glycans by reductive β-elimination has become routine in many glyco-analytical laboratories and concomitant release of N-glycans has repeatedly been observed. Revisiting this somewhat forgotten mode of N-glycan release revealed that all kinds of N-glycans including oligomannosidic and complex-type N-glycans from plants with 3-linked fucose and from mammals with or without 6-linked fucose and with sialic acid could be recovered. However, the mass spectra of the obtained products revealed very surprising facts. Even after 16 h incubation in 1 M sodium borohydride, a large part of the glycans occurred in reducing form. Moreover, about one third emerged in the form of the stable amino-functionalized 1-amino-1-deoxy-glycitol. When avoiding acidic conditions, considerable amounts of glycosylamine were observed. In addition, a compound with a reduced asparagine and de-N-acetylation products, in particular of sialylated glycans, was seen. The relative yields of the products reducing glycosylamine, reducing N-glycan, 1-amino-1-deoxy-glycitol or glycitol could be controlled by the release conditions, foremost by temperature and borohydride concentration. Thus, chemical release of N-glycans constitutes a cost-saving alternative to enzymatic hydrolysis for the preparation of precursors for the production of reference compounds for various formats of N-glycan analysis. Moreover, it allows to obtain a stable amino-functionalized glycan derivative, which can be employed to construct glycan arrays or affinity matrices. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Ionizing radiation damage in Micrococcus radiodurans cell wall: release of polysaccharide

International Nuclear Information System (INIS)

Mitchel, R.E.J.

1976-01-01

Sublethal 60 Co γ-irradiation of the bacterium Micrococcus radiodurans in aqueous suspension results in a loss of up to 6 percent of its cellular dry weight and 30 percent of its wet weight. In the process some specific cell wall polysaccharides, including a polymer of glucose and N-acylated glucosamine, are released into the surrounding medium. These polysaccharides appear to originate from a hydrophobic site in the middle, lipid-rich, cell wall layer. The damage to this layer which results in the release of these and other polymers may be due to a disruption of this hydrophobic site. The polysaccharide containing glucose and N-acylated glucosamine exists as a high molecular weight polymer in unirradiated cells, but irradiation causes some degradation prior to release. In a free state this polysaccharide is considerably less sensitive to radiolytic degradation than in a bound state. Free radicals generated from surrounding water by ionizing radiation initiate the release, hydroxyl radicals being the most important species. Oxygen protects the cell wall against loss of the polysaccharides, apparently by a mechanism which does not depend on the ability of O 2 to scavenge hydrogen atoms and aqueous electrons

Evaluating conditional release in not guilty by reason of insanity acquittees: a prospective follow-up study in Virginia.

Science.gov (United States)

Vitacco, Michael J; Vauter, Rebecca; Erickson, Steven K; Ragatz, Laurie

2014-08-01

Detailed research on treatment and risk management approaches with not guilty by reason of insanity acquittees (NGRI) during their conditional release is needed as states increasingly use community-based services for these individuals. Grounded in case law, and supported by follow-up studies demonstrating low recidivism rates, states have been encouraged in their efforts to conditionally release NGRI acquittees. The authors evaluated a state-wide sample of 127 NGRI acquittees released into the community after spending a mean of 61.63 months (SD = 76.54) in the hospital. One hundred individuals were committed to the hospital for lengthier treatment (M hospital time = 77.23 months, SD = 79.84), but 27 individuals were released to the community after a relatively short hospital stay (M hospital time = 5.60 months, SD = 3.01). Regarding release, 96 individuals (75.6%) maintained their conditional release. After evaluating a host of demographic and standardized risk data, the following variables predicted revocation on conditional release: previous failure on conditional release, nonadherence with hospital treatment, dangerousness to others, and previous violent charges. A multivariate survival analysis determined criminal behavior and previous failure on conditional release predicted time to revocation. The results of this study demonstrate the importance of considering standardized risk variables in the community-based management of forensic patients. In addition, the data are supportive of continued attempts at moving insanity acquittees from the hospital to the community via conditional release.

Flexible AC transmission systems: the state of the art

Energy Technology Data Exchange (ETDEWEB)

Edris, Abdel-Aty [Electric Power Research Inst., Palo Alto, CA (United States). Electric Systems Division

1994-12-31

Flexible AC transmission systems (FACTS) is a concept promoting the use of power electronic controllers to enhance the controllability and usable capacity of AC transmission. This paper presents the state of the art of FACTS and the status of the current projects for the application of the FACTS controllers in transmission systems. (author) 8 refs., 8 figs.

A steady-state mechanism can account for the properties of inositol 2,4,5-trisphosphate-stimulated Ca2+ release from permeabilized L1210 cells.

Science.gov (United States)

Loomis-Husselbee, J W; Dawson, A P

1993-01-01

We have investigated the effects of sub-maximal Ins(2,4,5)P3 concentrations on the Ca2+ permeability of the residual undischarged Ca2+ stores in electroporated or digitonin-permeabilized L1210 cells by measuring Ca(2+)-efflux rate after addition of the ATPase inhibitor thapsigargin. Low concentrations of Ins(2,4,5)P3, causing rapid discharge of a small proportion of the releasable Ca2+, result in a substantial stimulation of Ca2+ efflux after thapsigargin addition. This indicates firstly that in the absence of thapsigargin there must have been a substantial, counterbalancing, increase in rate of Ca2+ pumping, and secondly that the increased Ca2+ permeability is more consistent with a steady state than with a quantal model of Ca2+ release. Similar increases in passive Ca2+ permeability are produced by addition of concentrations of ionomycin which produce equivalent changes in Ca2+ loading to those produced by Ins(2,4,5)P3, although the time course and initial rate of Ca2+ release are very much slower. In the presence of a Ca(2+)-buffering system, the time course of Ca2+ release by Ins(2,4,5)P3 becomes superimposable on that of ionomycin, indicating that the initial rapid phase of Ins(2,4,5)P3-stimulated Ca2+ is at least partially due to positive feedback from extravesicular Ca2+. PMID:8382056

Sustained-release progesterone vaginal suppositories 1--development of sustained-release granule--.

Science.gov (United States)

Nakayama, Ayako; Sunada, Hisakazu; Okamoto, Hirokazu; Furuhashi, Kaoru; Ohno, Yukiko; Ito, Mikio

2009-02-01

Progesterone (P) is an important hormone for the establishment of pregnancy, and its administration is useful for luteal insufficiency. Considering the problems of commercially available oral and injection drugs, hospital-formulated vaginal suppositories are clinically used. However, since the half-life of P suppositories is short, it is difficult to maintain its constant blood concentration. To sustain drug efficacy and prevent side-effects, we are attempting to develop sustained-release suppositories by examining the degree of sustained-release of active ingredients. In this study, we examined the combinations of granulation methods and release systems for the preparation of sustained-release granules of P, and produced 13 types of sustained-release granules. We also examined the diameter, content, and dissolution of each type of granules, and confirmed that the sustained-release of all types of granules was satisfactory. Among the sustained-release granules, we selected granules with a content and a degree of sustained-release suitable for sustained-release suppositories.

Faith, Fact, and Behaviorism.

Science.gov (United States)

Staddon, J E R

2013-01-01

David Hume argued that ought cannot be derived from is . That is, no set of facts, no amount of scientific knowledge, is by itself sufficient to urge us to action. Yet generations of well-meaning scientists (more and more as secular influences grow in the West) seem to have forgotten Hume's words of wisdom. All motivated action depends ultimately on beliefs that cannot be proved by the methods of science, that is, on faith.

Biomolecular Science (Fact Sheet)

Energy Technology Data Exchange (ETDEWEB)

2012-04-01

A brief fact sheet about NREL Photobiology and Biomolecular Science. The research goal of NREL's Biomolecular Science is to enable cost-competitive advanced lignocellulosic biofuels production by understanding the science critical for overcoming biomass recalcitrance and developing new product and product intermediate pathways. NREL's Photobiology focuses on understanding the capture of solar energy in photosynthetic systems and its use in converting carbon dioxide and water directly into hydrogen and advanced biofuels.

Teaching English as A Foreign Language at Madrasah Ibtidaiyyah: Facts and Challenges

Directory of Open Access Journals (Sweden)

Wakhid Nashruddin

2015-06-01

Full Text Available The mastery of English as a tool of communication among nations, cultures, and people around the globe is an undeniable fact. This is just like an unstoppable virus spreading worldwide. It is rather difficult to emerge new languages to stop or even just to slow down the wide use of English. Islam world also needs to follow this by equipping its people with English as a communication tool. As Arabic is used for the communication inside Islam, English is needed to communicate Islam to other people around the earth both to Muslims or Non-Muslims. Teaching English has become an increasingly significant element in Islamic education. For this, the issue of teaching English at madrasah is an important concern for practitioners in the area of TEFL in Islamic institutions. This paper will explore the writer’s ten-year experience in teaching English at a madrasah ibtidaiyyah in Cirebon, West Java-Indonesia. The conditions that will be pictured are the culture, the students, the teaching and learning process, and the outcome of the current practices in madrasah ibtidaiyyah, mainly in the area of TEFL. Then, all these conditions will be contrasted to up to date research findings and theories so that the facts and the challenges can be clearly seen. This will also be seen from the perspective of current curriculum in Indonesia, namely curriculum 2013, which bears contradictions with the presence of it. In fact, the curriculum 2013 eliminates English as a subject learned at primary school level. What madrasah ibtidaiyyah will do in the next coming years can direct the expected outcome of the teaching of English at this level. Kinds of program that can be designed to empower the state of English mastery are an essential case to discuss. This all facts and challenges can provide insights so that people working in and with madrasah ibtidaiyyah understand and are ready to face the global communication era.

Impact of global financial crisis on stylized facts between energy markets and stock markets

Science.gov (United States)

Leng, Tan Kim; Cheong, Chin Wen; Hooi, Tan Siow

2014-06-01

Understanding the stylized facts is extremely important and has becomes a hot issue nowadays. However, recent global financial crisis that started from United States had spread all over the world and adversely affected the commodities and financial sectors of both developed and developing countries. This paper tends to examine the impact of crisis on stylized facts between energy and stock markets using ARCH-family models based on the experience over 2008 global financial crisis. Empirical results denote that there is long lasting, persists and positively significant the autocorrelation function of absolute returns and their squares in both markets for before and during crisis. Besides that, leverage effects are found in stock markets whereby bad news has a greater impact on volatility than good news for both before and during crisis. However, crisis does not indicate any impact on risk-return tradeoff for both energy and stock markets. For forecasting evaluations, GARCH model and FIAPARCH model indicate superior out of sample forecasts for before and during crisis respectively.

States on algebras of unbounded operators

International Nuclear Information System (INIS)

Timmermann, W.

1985-01-01

There are reviewed some of the fundamental results on normal states on algebras of unbounded operators. It is ndicated how these results are related with ideal theory. Few known facts concerning perturbation of normal states are included. There are contained some new results on singular states

Facts about Type 2

Medline Plus

Full Text Available ... Recipe Kits Delivered We've teamed up with Chef'd to bring you healthy recipe kits. Ways ... Us Policies Corporate Support Newsroom Press Releases For Professionals En Español Online Community Walk Bike Shop Sign ...

Fission product release modelling for application of fuel-failure monitoring and detection - An overview

Energy Technology Data Exchange (ETDEWEB)

Lewis, B.J., E-mail: lewibre@gmail.com [Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, K7K 7B4 (Canada); Chan, P.K.; El-Jaby, A. [Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, K7K 7B4 (Canada); Iglesias, F.C.; Fitchett, A. [Candesco Division of Kinectrics Inc., 26 Wellington Street East, 3rd Floor, Toronto, Ontario M5E 1S2 (Canada)

2017-06-15

A review of fission product release theory is presented in support of fuel-failure monitoring analysis for the characterization and location of defective fuel. This work is used to describe: (i) the development of the steady-state Visual-DETECT code for coolant activity analysis to characterize failures in the core and the amount of tramp uranium; (ii) a generalization of this model in the STAR code for prediction of the time-dependent release of iodine and noble gas fission products to the coolant during reactor start-up, steady-state, shutdown, and bundle-shifting manoeuvres; (iii) an extension of the model to account for the release of fission products that are delayed-neutron precursors for assessment of fuel-failure location; and (iv) a simplification of the steady-state model to assess the methodology proposed by WANO for a fuel reliability indicator for water-cooled reactors.

Fission product release from nuclear fuel I. Physical modelling in the ASTEC code

International Nuclear Information System (INIS)

Brillant, G.; Marchetto, C.; Plumecocq, W.

2013-01-01

Highlights: • Physical modeling of FP and SM release in ASTEC is presented. • The release is described as solid state diffusion within fuel for high volatile FP. • The release is described as FP vaporisation for semi volatile FP. • The release is described as fuel vaporisation for low volatile FP. • ASTEC validation is presented in the second paper. - Abstract: This article is the first of a series of two articles dedicated to the mechanisms of fission product release from a degraded core as they are modelled in the ASTEC code. The ASTEC code aims at simulating severe accidents in nuclear reactors from the initiating event up to the radiological consequences on the environment. This code is used for several applications such as nuclear plant safety evaluation including probabilistic studies and emergency preparedness. To cope with the requirements of robustness and low calculation time, the code is based on a semi-empirical approach and only the main limiting phenomena that govern the release from intact rods and from debris beds are considered. For solid fuel, fission products are classified into three groups, depending on their degree of volatility. The kinetics of volatile fission products release depend on the rate-limiting process of solid-state diffusion through fuel grains. For semi-volatile fission products, the release from the open fuel porosities is assumed to be governed by vaporisation and mass transfer processes. The key phenomenon for the release of low volatile fission products is supposed to be fuel volatilisation. A similar approach is used for the release of fission products from a rubble bed. An in-depth validation of the code including both analytical and integral experiments is the subject of the second article

Influence of start up and pulsed operation on tritium release and inventory of NET ceramic blanket

International Nuclear Information System (INIS)

Iseli, M.; Esser, B.

1989-01-01

A first estimate for the tritium release behaviour of a ceramic breeder blanket in pulsed operation is obtained by assuming a linear steady state temperature distribution and taking into account the time constant of the thermal behaviour. The release behaviour of the breeder exposed to consecutive periods of tritium generation is described with an analytical solution of the diffusion equation. The results are compared with a simple exponential approach valid for surfacte desorption controlled release. The exponential model is used to simulate a blanket with aluminate as breeder material, which takes longest to reach steady state. The simulation demonstrates that a significant fraction (>67%) of steady state can be achieved after a testing time of about one day. (author). 7 refs.; 8 figs.; 3 tabs

Environmental technology applications: fact file on toxic contaminants in industrial waste process streams

Energy Technology Data Exchange (ETDEWEB)

Newkirk, H.W.

1977-05-11

This report is a compendium of facts related to chemical materials present in industrial waste process streams which have already been declared or are being evaluated as hazardous under the Toxic Substances Control Act. Since some 400 chemicals are presently covered by consensus standards, the substances reviewed are only those considered to be a major threat to public health and welfare by Federal and State regulatory agencies. For each hazardous material cited, the facts relate, where possible, to an identification of the stationary industrial sources, the kind of waste stream impacted, proposed regulations and established effluent standards, the volume of emissions produced each year, the volume of emissions per unit of industrial product produced, present clean-up capabilities, limitations, and costs. These data should be helpful in providing information for the assessment of potential problems, should be of use to the manufacturers of pollution control equipment or of chemicals for pollution control, should be of use to the operators or potential operators of processes which produce pollutants, and should help to define industry-wide emission practices and magnitudes.

Recommended plutonium release fractions from postulated fires. Final report

International Nuclear Information System (INIS)

Kogan, V.; Schumacher, P.M.

1993-12-01

This report was written at the request of EG ampersand G Rocky Flats, Inc. in support of joint emergency planning for the Rocky Flats Plant (RFP) by EG ampersand G and the State of Colorado. The intent of the report is to provide the State of Colorado with an independent assessment of any respirable plutonium releases that might occur in the event of a severe fire at the plant. Fire releases of plutonium are of interest because they have been used by EG ampersand G to determine the RFP emergency planning zones. These zones are based on the maximum credible accident (MCA) described in the RFP Final Environmental Impact Statement (FEIS) of 1980, that MCA is assumed to be a large airplane crashing into a RFP plutonium building.The objective of this report was first, to perform a worldwide literature review of relevant release experiments from 1960 to the present and to summarize those findings, and second, to provide recommendations for application of the experimental data to fire release analyses at Rocky Flats. The latter step requires translation between experimental and expected RFP accident parameters, or ''scaling.'' The parameters of particular concern are: quantities of material, environmental parameters such as the intensity of a fire, and the physico-chemical forms of the plutonium. The latter include plutonium metal, bulk plutonium oxide powder, combustible and noncombustible wastes contaminated with plutonium oxide powder, and residues from plutonium extraction processes

International comparison on radioactive releases of PWR between 1975 and 1988

International Nuclear Information System (INIS)

Benedittini, M.; Tabare, M.

1990-02-01

This report presents the main results of a comparison on radioactive releases from 135 PWRs in the following countries: Belgium, Federal Republic of Germany, Finland, France, Japan, Sweden, Switzerland and the United States. For liquid releases, distinctions have been undertaken between tritium and no tritium activities and for gaseous releases between noble gases and halogens-aerosols. Data has been collected from literature published or by contacting utilities administrative staff or authorities in order to constitute a data base. As regards this comparison however, reactors, the commercial operation of which started prior to July 1974, have been excluded [fr

Nanotechnology for Site Remediation: Fact Sheet

Science.gov (United States)

This fact sheet presents a snapshot of nanotechnology and its current uses in remediation. It presents information to help site project managers understand the potential applications of this group of technologies at their sites.

HIV and AIDS: Know the Facts

Science.gov (United States)

... Special Issues Subscribe June 2015 Print this issue HIV and AIDS: Know the Facts Treatments Work, but ... Biological Blueprints Wise Choices Should You Get an HIV Test? HIV tests involve a simple cheek swab, ...

HIV/AIDS Clinical Trials Fact Sheet

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... AIDS Drugs Clinical Trials Apps skip to content HIV Overview Home Understanding HIV/AIDS Fact Sheets HIV/ ... 4 p.m. ET) Send us an email HIV/AIDS Clinical Trials Last Reviewed: August 25, 2017 ...

Description of tritium release from lithium titanate at constant temperature

Energy Technology Data Exchange (ETDEWEB)

Pena, L; Lagos, S; Jimenez, J; Saravia, E [Comision Chilena de Energia Nuclear, Santiago (Chile)

1998-03-01

Lithium Titanate Ceramics have been prepared by the solid-state route, pebbles and pellets were fabricated by extrusion and their microstructure was characterized in our laboratories. The ceramic material was irradiated in the La Reina Reactor, RECH-1. A study of post-irradiation annealing test, was performed measuring Tritium release from the Lithium Titanate at constant temperature. The Bertone`s method modified by R. Verrall is used to determine the parameters of Tritium release from Lithium Titanate. (author)

Epilepsy: General Information. Fact Sheet Number 6 = La Epilepsia: Informacion General. Fact Sheet Number 20.

Science.gov (United States)

Interstate Research Associates, McLean, VA.

This fact sheet on epilepsy is offered in both English and Spanish. It provides a definition, information on incidence, typical characteristics, and educational implications. It notes that epilepsy is classified as "other health impaired" under the Individuals with Disabilities Education Act and that students with epilepsy are eligible for special…

Load-Unload Response Ratio (LURR), Accelerating Moment/Energy Release (AM/ER) and State Vector Saltation as Precursors to Failure of Rock Specimens

Science.gov (United States)

Yin, Xiang-Chu; Yu, Huai-Zhong; Kukshenko, Victor; Xu, Zhao-Yong; Wu, Zhishen; Li, Min; Peng, Keyin; Elizarov, Surgey; Li, Qi

2004-12-01

In order to verify some precursors such as LURR (Load/Unload Response Ratio) and AER (Accelerating Energy Release) before large earthquakes or macro-fracture in heterogeneous brittle media, four acoustic emission experiments involving large rock specimens under tri-axial stress, have been conducted. The specimens were loaded in two ways: monotonous or cycling. The experimental results confirm that LURR and AER are precursors of macro-fracture in brittle media. A new measure called the state vector has been proposed to describe the damage evolution of loaded rock specimens.

Surface radiological free release program for the Battelle Columbus Laboratory Decommissioning Project

International Nuclear Information System (INIS)

Horton, C.N.

1995-01-01

This paper was prepared for the Second Residual Radioactivity and Recycling Criteria Workshop and discusses decommissioning and decontamination activities at the Battelle Columbus Laboratories Decommissioning Project (BCLDP). The BCLDP is a joint effort between the Department of Energy (DOE) and Battelle Columbus Operations to decontaminate fifteen Battelle-owned buildings contaminated with DOE radioactive materials. The privately owned buildings located across the street from The Ohio State University campus became contaminated with natural uranium and thorium during nuclear research activities. BCLDP waste management is supported by an extensive radiological free-release program. Miscellaneous materials and building surfaces have been free-released from the BCLDP. The free-release program has substantially reduced radioactive waste volumes and supported waste minimization. Free release for unrestricted use has challenged regulators and NRC licensees since the development of early surface-release criteria. This paper discusses the surface radiological free-release program incorporated by the BCLDP and the historical development of the surface radiological free-release criteria. Concerns regarding radiological free-release criteria are also presented. (author)

Hazardous substances releases associated with Hurricanes Katrina and Rita in industrial settings, Louisiana and Texas.

Science.gov (United States)

Ruckart, Perri Zeitz; Orr, Maureen F; Lanier, Kenneth; Koehler, Allison

2008-11-15

The scientific literature concerning the public health response to the unprecedented hurricanes striking the Gulf Coast in August and September 2005 has focused mainly on assessing health-related needs and surveillance of injuries, infectious diseases, and other illnesses. However, the hurricanes also resulted in unintended hazardous substances releases in the affected states. Data from two states (Louisiana and Texas) participating in the Hazardous Substances Emergency Events Surveillance (HSEES) system were analyzed to describe the characteristics of hazardous substances releases in industrial settings associated with Hurricanes Katrina and Rita. HSEES is an active multi-state Web-based surveillance system maintained by the Agency for Toxic Substances and Disease Registry (ATSDR). In 2005, 166 hurricane-related hazardous substances events in industrial settings in Louisiana and Texas were reported. Most (72.3%) releases were due to emergency shut downs in preparation for the hurricanes and start-ups after the hurricanes. Emphasis is given to the contributing causal factors, hazardous substances released, and event scenarios. Recommendations are made to prevent or minimize acute releases of hazardous substances during future hurricanes, including installing backup power generation, securing equipment and piping to withstand high winds, establishing procedures to shutdown process operations safely, following established and up-to-date start-up procedures and checklists, and carefully performing pre-start-up safety reviews.

Hazardous substances releases associated with Hurricanes Katrina and Rita in industrial settings, Louisiana and Texas

International Nuclear Information System (INIS)

Ruckart, Perri Zeitz; Orr, Maureen F.; Lanier, Kenneth; Koehler, Allison

2008-01-01

The scientific literature concerning the public health response to the unprecedented hurricanes striking the Gulf Coast in August and September 2005 has focused mainly on assessing health-related needs and surveillance of injuries, infectious diseases, and other illnesses. However, the hurricanes also resulted in unintended hazardous substances releases in the affected states. Data from two states (Louisiana and Texas) participating in the Hazardous Substances Emergency Events Surveillance (HSEES) system were analyzed to describe the characteristics of hazardous substances releases in industrial settings associated with Hurricanes Katrina and Rita. HSEES is an active multi-state Web-based surveillance system maintained by the Agency for Toxic Substances and Disease Registry (ATSDR). In 2005, 166 hurricane-related hazardous substances events in industrial settings in Louisiana and Texas were reported. Most (72.3%) releases were due to emergency shut downs in preparation for the hurricanes and start-ups after the hurricanes. Emphasis is given to the contributing causal factors, hazardous substances released, and event scenarios. Recommendations are made to prevent or minimize acute releases of hazardous substances during future hurricanes, including installing backup power generation, securing equipment and piping to withstand high winds, establishing procedures to shutdown process operations safely, following established and up-to-date start-up procedures and checklists, and carefully performing pre-start-up safety reviews

Hazardous substances releases associated with Hurricanes Katrina and Rita in industrial settings, Louisiana and Texas

Energy Technology Data Exchange (ETDEWEB)

Ruckart, Perri Zeitz [Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA (United States)], E-mail: afp4@cdc.gov; Orr, Maureen F. [Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA (United States); Lanier, Kenneth; Koehler, Allison [Louisiana Department of Health and Hospitals, Office of Public Health, New Orleans, LA (United States)

2008-11-15

The scientific literature concerning the public health response to the unprecedented hurricanes striking the Gulf Coast in August and September 2005 has focused mainly on assessing health-related needs and surveillance of injuries, infectious diseases, and other illnesses. However, the hurricanes also resulted in unintended hazardous substances releases in the affected states. Data from two states (Louisiana and Texas) participating in the Hazardous Substances Emergency Events Surveillance (HSEES) system were analyzed to describe the characteristics of hazardous substances releases in industrial settings associated with Hurricanes Katrina and Rita. HSEES is an active multi-state Web-based surveillance system maintained by the Agency for Toxic Substances and Disease Registry (ATSDR). In 2005, 166 hurricane-related hazardous substances events in industrial settings in Louisiana and Texas were reported. Most (72.3%) releases were due to emergency shut downs in preparation for the hurricanes and start-ups after the hurricanes. Emphasis is given to the contributing causal factors, hazardous substances released, and event scenarios. Recommendations are made to prevent or minimize acute releases of hazardous substances during future hurricanes, including installing backup power generation, securing equipment and piping to withstand high winds, establishing procedures to shutdown process operations safely, following established and up-to-date start-up procedures and checklists, and carefully performing pre-start-up safety reviews.

Depth of Information Processing and Memory for Medical Facts.

Science.gov (United States)

Slade, Peter D.; Onion, Carl W. R.

1995-01-01

The current emphasis in medical education is on engaging learners in deep processing of information to achieve better understanding of the subject matter. Traditional approaches aimed for memorization of medical facts; however, a good memory for medical facts is still essential in clinical practice. This study demonstrates that deep information…

On the burnout in annular channels at non-uniform heat release distribution in length

International Nuclear Information System (INIS)

Ornatskij, A.P.; Chernobaj, V.A.; Vasil'ev, A.F.; Struts, G.V.

1982-01-01

The effect of axial heat release non-uniformity on the conditions of the burnout in annular channels is investigated. The investigation is carried out in annular channels with different laws of heat flux density distribution by channel length. The heat release non-uniformity coefficient was varied from 4.4 to 10, the pressure from 9.8 to 17.6 MPa, mass rate from 500 to 1700 kg (m 2 xS), liquid temperature (chemically desalted water) at the channel inlet constituted 30-300 deg C. The experiments have been performed at the test bench with a closed circulation circuit. The data obtained testify to the fact that under non-uniform heat release the influence of main operating parameters on the value of critical power is of the same character as under uniform heat release. The character of wall temperature variation by channel length before the burnout is determined by the form of heat supply temperature profile. The temperature maximum is observed in the region lying behind the cross section with maximum heat flux. The conclusion is drawn that the dominant influence on the position of the cross section in which the burnout arises is exerted by the form of heat flux density distribution by length. Independently of this distribution form the burnout developes when the vapour content near the wall reaches a limiting value

Creutzfeldt-Jakob Disease Fact Sheet for Healthcare Workers and Morticians

Science.gov (United States)

... here Home » Disorders » Patient & Caregiver Education » Fact Sheets Creutzfeldt-Jakob Disease Fact Sheet for Healthcare Workers and Morticians Creutzfeldt-Jakob disease (CJD) is a rare, fatal brain disorder that ...

Droplet trapping and fast acoustic release in a multi-height device with steady-state flow.

Science.gov (United States)

Rambach, Richard W; Linder, Kevin; Heymann, Michael; Franke, Thomas

2017-10-11

We demonstrate a novel multilayer polydimethylsiloxane (PDMS) device for selective storage and release of single emulsion droplets. Drops are captured in a microchannel cavity and can be released on-demand through a triggered surface acoustic wave pulse. The surface acoustic wave (SAW) is excited by a tapered interdigital transducer (TIDT) deposited on a piezoelectric lithium niobate (LiNbO 3 ) substrate and inverts the pressure difference across the cavity trap to push a drop out of the trap and back into the main flow channel. Droplet capture and release does not require a flow rate change, flow interruption, flow inversion or valve action and can be achieved in as fast as 20 ms. This allows both on-demand droplet capture for analysis and monitoring over arbitrary time scales, and continuous device operation with a high droplet rate of 620 drops per s. We hence decouple long-term droplet interrogation from other operations on the chip. This will ease integration with other microfluidic droplet operations and functional components.

Facts about Type 2

Medline Plus

Full Text Available ... errors); $.each(surveyErrors, function () { if (this.errorField) { $('input[name="' + this.errorField + '"]').closest('.form-group') .prepend(' ' + ' ' + this.errorMessage + ' ' + ' '); } }); $('. ... Us Who We Are Careers Contact Us Policies Corporate Support Newsroom Press Releases For Professionals En Español ...

39 CFR 230.5 - Release of information.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Release of information. 230.5 Section 230.5 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION OFFICE OF INSPECTOR GENERAL General..., contained in Section 552 of Title 5 of the U.S. Code and 39 U.S.C. 410 (c), and/or the Privacy Act, Section...

NASA Facts, The Viking Mission.

Science.gov (United States)

National Aeronautics and Space Administration, Washington, DC. Educational Programs Div.

Presented is one of a series of publications of National Aeronautics and Space Administration (NASA) facts about the exploration of Mars. The Viking mission to Mars, consisting of two unmanned NASA spacecraft launched in August and September, 1975, is described. A description of the spacecraft and their paths is given. A diagram identifying the…

Fuels planning: science synthesis and integration; social issues fact sheet 07: The "laws" of effective public education about fire hazards

Science.gov (United States)

Rocky Mountain Research Station USDA Forest Service

2004-01-01

Within the past 10 years, breakthrough research has identified factors that are most important for effectively communicating about wildland fire hazards. This fact sheet discusses seven "Laws" of effective public communication that should be considered in any state-of-the-art education campaign.

Pore geometry of ceramic device: The key factor of drug release kinetics

Directory of Open Access Journals (Sweden)

Čolović B.

2013-01-01

Full Text Available Release kinetics of tigecycline, a potential antibiotic in treatment of osteomyelitis, from calcium hydroxyapatite (CHA, as one of the most important ceramic materials in bone tissue engineering, was investigated in this study. Tigecycline, in solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets using two different pressures. These tablets were immersed in a phosphate-buffered saline solution and tigecycline release was measured by a UV-VIS spectrophotometer. The total release time was 5 or 28 days, depending on the pressure applied during compression. It was shown that there is a close relationship between pore sizes and drug release rate. The drug release kinetics was interpreted on the base of pore sizes and pore size distribution. [Projekat Ministarstva nauke Republike Srbije, br. 172026

Key Facts about Seasonal Flu Vaccine

Science.gov (United States)

... Swine Variant Pandemic Other Key Facts About Seasonal Flu Vaccine Language: English (US) Español Recommend on Facebook ... the flu is to get vaccinated each year. Flu Vaccination Why should people get vaccinated against the ...

Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse

Directory of Open Access Journals (Sweden)

Guy eMalkinson

2013-09-01

Full Text Available Much of what we know about the mechanisms underlying Homosynaptic Depression (HSD and heterosynaptic facilitation is based on intracellular recordings of integrated postsynaptic potentials. This methodological approach views the presynaptic apparatus as a single compartment rather than taking a more realistic representation reflecting the fact that it is made up of tens to hundreds of individual and independent Presynaptic Release Boutons (PRBs. Using cultured Aplysia sensorimotor synapses, we reexamined HSD and its dishabituation by imaging the release properties of individual PRBs. We find that the PRB population is heterogeneous and can be clustered into three groups: approximately 25% of the PRBs consistently release neurotransmitter throughout the entire habituation paradigm (35 stimuli, 0.05Hz and have a relatively high quantal content, 36% of the PRBs display intermittent failures only after the tenth stimulation, and 39% are low quantal-content PRBs that exhibit intermittent release failures from the onset of the habituation paradigm. 5HT-induced synaptic dishabituation by a single 5HT application was generated by the enhanced recovery of the quantal content of the habituated PRBs and did not involve the recruitment of new release boutons. The characterization of the PRB population as heterogeneous in terms of its temporal pattern of release-probability and quantal content provides new insights into the mechanisms underlying HSD and its dishabituation.

Role of In Vitro Release Methods in Liposomal Formulation Development: Challenges and Regulatory Perspective.

Science.gov (United States)

Solomon, Deepak; Gupta, Nilesh; Mulla, Nihal S; Shukla, Snehal; Guerrero, Yadir A; Gupta, Vivek

2017-11-01

In the past few years, measurement of drug release from pharmaceutical dosage forms has been a focus of extensive research because the release profile obtained in vitro can give an indication of the drug's performance in vivo. Currently, there are no compendial in vitro release methods designed for liposomes owing to a range of experimental challenges, which has created a major hurdle for both development and regulatory acceptance of liposome-based drug products. In this paper, we review the current techniques that are most often used to assess in vitro drug release from liposomal products; these include the membrane diffusion techniques (dialysis, reverse dialysis, fractional dialysis, and microdialysis), the sample-and-separate approach, the in situ method, the continuous flow, and the modified United States Pharmacopeia methods (USP I and USP IV). We discuss the principles behind each of the methods and the criteria that assist in choosing the most appropriate method for studying drug release from a liposomal formulation. Also, we have included information concerning the current regulatory requirements for liposomal drug products in the United States and in Europe. In light of increasing costs of preclinical and clinical trials, applying a reliable in vitro release method could serve as a proxy to expensive in vivo bioavailability studies. Graphical Abstract Appropriate in-vitro drug release test from liposomal products is important to predict the in-vivo performance.

A role for FACT in repopulation of nucleosomes at inducible genes.

Directory of Open Access Journals (Sweden)

Warren P Voth

Full Text Available Xenobiotic drugs induce Pleiotropic Drug Resistance (PDR genes via the orthologous Pdr1/Pdr3 transcription activators. We previously identified the Mediator transcription co-activator complex as a key target of Pdr1 orthologs and demonstrated that Pdr1 interacts directly with the Gal11/Med15 subunit of the Mediator complex. Based on an interaction between Pdr1 and the FACT complex, we show that strains with spt16 or pob3 mutations are sensitive to xenobiotic drugs and display diminished PDR gene induction. Although FACT acts during the activation of some genes by assisting in the nucleosomes eviction at promoters, PDR promoters already contain nucleosome-depleted regions (NDRs before induction. To determine the function of FACT at PDR genes, we examined the kinetics of RNA accumulation and changes in nucleosome occupancy following exposure to a xenobiotic drug in wild type and FACT mutant yeast strains. In the presence of normal FACT, PDR genes are transcribed within 5 minutes of xenobiotic stimulation and transcription returns to basal levels by 30-40 min. Nucleosomes are constitutively depleted in the promoter regions, are lost from the open reading frames during transcription, and the ORFs are wholly repopulated with nucleosomes as transcription ceases. While FACT mutations cause minor delays in activation of PDR genes, much more pronounced and significant defects in nucleosome repopulation in the ORFs are observed in FACT mutants upon transcription termination. FACT therefore has a major role in nucleosome redeposition following cessation of transcription at the PDR genes, the opposite of its better-known function in nucleosome disassembly.

The Temperature Condition of the Plate with Temperature-Dependent Thermal Conductivity and Energy Release

Directory of Open Access Journals (Sweden)

V. S. Zarubin

2016-01-01

Full Text Available The temperature state of a solid body, in addition to the conditions of its heat exchange with the environment, can greatly depend on the heat release (or heat absorption processes within the body volume. Among the possible causes of these processes should be noted such as a power release in the fuel elements of nuclear reactors, exothermic or endothermic chemical reactions in the solid body material, which respectively involve heat release or absorbtion, heat transfer of a part of the electric power in the current-carrying conductors (so-called Joule’s heat or the energy radiation penetrating into the body of a semitransparent material, etc. The volume power release characterizes an intensity of these processes.The extensive list of references to the theory of heat conductivity of solids offers solutions to problems to determine a stationary (steady over time and non-stationary temperature state of the solids (as a rule, of the canonical form, which act as the sources of volume power release. Thus, in general case, a possibility for changing power release according to the body volume and in solving the nonstationary problems also a possible dependence of this value on the time are taken into consideration.However, in real conditions the volume power release often also depends on the local temperature, and such dependence can be nonlinear. For example, with chemical reactions the intensity of heat release or absorption is in proportion to their rate, which, in turn, is sensitive to the temperature value, and a dependence on the temperature is exponential. A further factor that in such cases makes the analysis of the solid temperature state complicated, is dependence on the temperature and the thermal conductivity of this body material, especially when temperature distribution therein  is significantly non-uniform. Taking into account the influence of these factors requires the mathematical modeling methods, which allow us to build an adequate

Tuberculosis Facts - TB and HIV/AIDS

Science.gov (United States)

Tuberculosis (TB) Facts TB and HIV/AIDS What is TB? “TB” is short for a disease called tuberculosis. TB is spread through the air from one ... Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination

Youth Violence: Facts at a Glance

Science.gov (United States)

Youth Violence Facts at a Glance 2016 Yout h Vi olence • In 2014, 4,300 young people ages 10 ... in combined medical and work loss costs. 1 Violence-related Behaviors In a 2015 nationally-representative sample ...

Case Management for Individuals with Mental Retardation. ARC Facts.

Science.gov (United States)

Association for Retarded Citizens, Arlington, TX.

A question-and-answer format is used in this fact sheet to provide information on case management for individuals with mental retardation. The fact sheet describes the major components of a case management system, the role of the case manager, the individual's or family's role in case management, providers of case management services and systems…

Assessing the FACTS at Kayenta

Energy Technology Data Exchange (ETDEWEB)

Pereira, M.; Renz, K.; Unterla, F. (Siemens AG Unternehmensbereich KWU, Erlangen (Germany))

1993-12-01

The world's first advanced series compensator with controllable series impedance as a flexible AC transmission (FACTS) device has been introduced at Western Area Power Administration's Kayenta substation in Arizona, USA. The system, which has been in operation for a year, allows existing transmission lines to carry up to 33 per cent more power. (author)

Drug release kinetic analysis and prediction of release data via polymer molecular weight in sustained release diltiazem matrices.

Science.gov (United States)

Adibkia, K; Ghanbarzadeh, S; Mohammadi, G; Khiavi, H Z; Sabzevari, A; Barzegar-Jalali, M

2014-03-01

This study was conducted to investigate the effects of HPMC (K4M and K100M) as well as tragacanth on the drug release rate of diltiazem (DLTZ) from matrix tablets prepared by direct compression method.Mechanism of drug transport through the matrices was studied by fitting the release data to the 10 kinetic models. 3 model independent parameters; i. e., mean dissolution time (MDT), mean release rate (MRR) and release rate efficacy (RE) as well as 5 time point approaches were established to compare the dissolution profiles. To find correlation between fraction of drug released and polymer's molecular weight, dissolution data were fitted into two proposed equations.All polymers could sustain drug release up to 10 h. The release data were fitted best to Peppas and Higuchi square root kinetic models considering squared correlation coefficient and mean percent error (MPE). RE and MRR were decreased when polymer to drug ratio was increased. Conversely, t60% was increased with raising polymer /drug ratio. The fractions of drug released from the formulations prepared with tragacanth were more than those formulated using the same amount of HPMC K4M and HPMC K100M.Preparation of DLTZ matrices applying HPMCK4M, HPMC K100M and tragacanth could effectively extend the drug release. © Georg Thieme Verlag KG Stuttgart · New York.

Imitating manual curation of text-mined facts in biomedicine.

Directory of Open Access Journals (Sweden)

Raul Rodriguez-Esteban

2006-09-01

Full Text Available Text-mining algorithms make mistakes in extracting facts from natural-language texts. In biomedical applications, which rely on use of text-mined data, it is critical to assess the quality (the probability that the message is correctly extracted of individual facts--to resolve data conflicts and inconsistencies. Using a large set of almost 100,000 manually produced evaluations (most facts were independently reviewed more than once, producing independent evaluations, we implemented and tested a collection of algorithms that mimic human evaluation of facts provided by an automated information-extraction system. The performance of our best automated classifiers closely approached that of our human evaluators (ROC score close to 0.95. Our hypothesis is that, were we to use a larger number of human experts to evaluate any given sentence, we could implement an artificial-intelligence curator that would perform the classification job at least as accurately as an average individual human evaluator. We illustrated our analysis by visualizing the predicted accuracy of the text-mined relations involving the term cocaine.

Stylized facts in social networks: Community-based static modeling

Science.gov (United States)

Jo, Hang-Hyun; Murase, Yohsuke; Török, János; Kertész, János; Kaski, Kimmo

2018-06-01

The past analyses of datasets of social networks have enabled us to make empirical findings of a number of aspects of human society, which are commonly featured as stylized facts of social networks, such as broad distributions of network quantities, existence of communities, assortative mixing, and intensity-topology correlations. Since the understanding of the structure of these complex social networks is far from complete, for deeper insight into human society more comprehensive datasets and modeling of the stylized facts are needed. Although the existing dynamical and static models can generate some stylized facts, here we take an alternative approach by devising a community-based static model with heterogeneous community sizes and larger communities having smaller link density and weight. With these few assumptions we are able to generate realistic social networks that show most stylized facts for a wide range of parameters, as demonstrated numerically and analytically. Since our community-based static model is simple to implement and easily scalable, it can be used as a reference system, benchmark, or testbed for further applications.

Fuels planning: science synthesis and integration; environmental consequences fact sheet 13: Root Disease Analyzer-Armillaria Response Tool (ART)

Science.gov (United States)

Geral I. McDonald; Philip D. Tanimoto; Thomas M. Rice; David E. Hall; Jane E. Stewart; Paul J. Zambino; Jonalea R. Tonn; Ned B. Klopfenstein; Mee-Sook Kim

2005-01-01

The Root Disease Analyzer-Armillaria Response Tool (ART) is a Web-based tool that estimates Armillaria root disease risk in dry forests of the Western United States. This fact sheet identifies the intended users and uses, required inputs, what the model does and does not do, and tells the user how to obtain the model.

Reshock and release response of aluminum single crystal

International Nuclear Information System (INIS)

Huang, H.; Asay, J. R.

2007-01-01

Reshock and release experiments were performed on single crystal aluminum along three orientations and on polycrystalline 1050 aluminum with 50 μm grain size at shock stresses of 13 and 21 GPa to investigate the mechanisms for previously observed quasielastic recompression behavior. Particle velocity profiles obtained during reshocking both single crystals and polycrystalline aluminum from initial shock stresses of 13-21 GPa show similar quasielastic recompression behavior. Quasielastic release response is also observed in all single crystals, but the magnitude of the effect is crystal orientation dependent, with [111] and [110] exhibiting more ideal elastic-plastic release for unloading from the shocked state than for the [100] orientation and polycrystalline aluminum. The quasielastic response of 1050 aluminum is intermediate to that of the [100] and [111] orientations. Comparison of the wave profiles obtained for both unloading and reloading of single crystals and polycrystalline 1050 aluminum from shocked states suggests that the observed quasielastic response of polycrystalline aluminum results from the averaging response of single crystals for shock propagation along different orientations, and that the response of 1050 aluminum with large grain boundaries is not significantly different from the results obtained on single crystal aluminum. The yield strength of the single crystals and 1050 aluminum is found to increase with shock stress, which is consistent with previous results [H. Huang and I. R. Asay, J. Appl. Phys. 98, 033524 (2005)

Release of a Poorly Soluble Drug from Hydrophobically Modified Poly (Acrylic Acid in Simulated Intestinal Fluids.

Directory of Open Access Journals (Sweden)

Patrik Knöös

Full Text Available A large part of new pharmaceutical substances are characterized by a poor solubility and high hydrophobicity, which might lead to a difference in drug adsorption between fasted and fed patients. We have previously evaluated the release of hydrophobic drugs from tablets based on Pemulen TR2 and showed that the release can be manipulated by adding surfactants. Here we further evaluate the possibility to use Pemulen TR2 in controlled release tablet formulations containing a poorly soluble substance, griseofulvin. The release is evaluated in simulated intestinal media that model the fasted state (FaSSIF medium or fed state (FeSSIF. The rheology of polymer gels is studied in separate experiments, in order to gain more information on possible interactions. The release of griseofulvin in tablets without surfactant varied greatly and the slowest release were observed in FeSSIF. Addition of SDS to the tablets eliminated the differences and all tablets showed a slow linear release, which is of obvious relevance for robust drug delivery. Comparing the data from the release studies and the rheology experiment showed that the effects on the release from the different media could to a large extent be rationalised as a consequence of the interactions between the polymer and the surfactants in the media. The study shows that Pemulen TR2 is a candidate for controlled release formulations in which addition of surfactant provides a way to eliminate food effects on the release profile. However, the formulation used needs to be designed to give a faster release rate than the tablets currently investigated.

Oxide fuel fabrication technology development of the FaCT project (1). Overall review of fuel technology development of the FaCT project

International Nuclear Information System (INIS)

Abe, Tomoyuki; Namekawa, Takashi; Tanaka, Kenya

2011-01-01

The FaCT project is in progress in Japan for the commercialization of fast reactor cycle system. The development goal of the fuel in the FaCT project is a low-decontaminated TRU homo-recycling in a closed cycle and extension in average discharge burn-up to 150 GWd/t. Research and development on innovative technologies concerning the short process, remote maintenance and cooling system of automatic fuel production equipments, long life cladding material and control of oxygen potential have been conducted in phase I of the FaCT project. As the result of various test including 600 g batch MOX tests, it is concluded that the short process is available to fuel pellet fabrication of the FaCT project. Although cold mock-up tests on test model of some typical process equipments suggest possibilities of remote maintenance of automatic fuel fabrication equipment, it is concluded that it still needs further efforts to judge the operability of the completely remote fabrication for low-decontaminated TRU fuel. A cold mock-up test on fuel pin assembling equipment show that influence of decay heat of MA can be managed by cooling system. Irradiation tests in BOR-60 indicate that 9Cr-ODS possess the satisfactory in-reactor performance as the long life cladding material if homogeneity of alloy element is adequately controlled. Modification of cladding tube fabrication process to ensure homogeneity and further development of measures to control oxygen potential inside the fuel pin are necessary to reach the burn-up target of the FaCT project. (author)

Myths and Facts about Suicide from Individuals Involved in Suicide Prevention

Science.gov (United States)

Schurtz, David R.; Cerel, Julie; Rodgers, Philip

2010-01-01

Myth-busting, in which a so-called myth is presented and dispelled by facts, is used in suicide prevention gatekeeper trainings such as QPR. Evidence from other areas of public health shows this technique leads to memory for myths and not facts. An internet survey was used to determine if the "myths" and "facts" presented in QPR are endorsed as…

In vitro labelled neurotransmitters release for the study of neuro toxins

International Nuclear Information System (INIS)

Camillo, Maria A.P.; Rogero, Jose R.; Troncone, Lanfranco R.P.

1995-01-01

There is an increasing concern in the replacement of in vivo by in vitro methods in Pharmacology. Looking for a method which involves the most of the physiological aspects related to neural functions, a super fusion system designed to evaluate in vitro neurotransmitter release from brain striatal tissue is here described. The method is based on the basal and stimulated release of pre-loaded tritium-labelled neurotransmitters. This procedure bears an active uptake/release function which is fairly changed by membrane polarisation state, ion channel activation and enzymatic activity, as well as other still unknown steps involved in neurotransmission. Calcium dependency of dopamine and acetylcholine release induced by high potassium depolarization or glutamate (Glu) stimulation was demonstrated employing calcium-free (+EGTA) super fusion or lanthanum/cadmium addition. Glutamate stimulation involved NMDA receptors since magnesium or MK801 blocks stimulated release. Uptake of DA and Ach was evidenced by using bupropione or hemicolinium-3. presynaptic inhibition of Ach release was evidenced by physostigmine-induced inhibitions of acetylcholinesterase. (author). 3 refs., 6 figs

Meteorological conditions at the release site during the two tracer experiments

DEFF Research Database (Denmark)

Gryning, Sven-Erik; Batchvarova, E.; Schneiter, D.

1998-01-01

The state of the boundary layer at the release site during the two tracer experiments is described, based on measurements of atmospheric turbulence carried our by a sonic anemometer, profiles of horizontal and vertical wind by a SODAR as well as frequent radiosonde releases. The boundary layer...... height is derived from radiosoundings, modelled and discussed. The study is meant as background for discussions of the tracer behaviour near the release site, and possible influence of the local meteorology at the release site on the long-range dispersion. The difference in the initial mese...... model development. It is concluded that the micrometeorological measurements are very important as background information for the understanding of plume behaviour on small as well as long scales. (C) 1998 Elsevier Science Ltd. All rights reserved....

News/Press Releases

Data.gov (United States)

Office of Personnel Management — A press release, news release, media release, press statement is written communication directed at members of the news media for the purpose of announcing programs...

12 CFR 404.6 - Release of records under the Freedom of Information Act.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Release of records under the Freedom of Information Act. 404.6 Section 404.6 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Procedures for Disclosure of Records Under the Freedom of Information Act. § 404.6 Release of...

SU-F-19A-08: Optimal Time Release Schedule of In-Situ Drug Release During Permanent Prostate Brachytherapy

International Nuclear Information System (INIS)

Cormack, R; Ngwa, W; Makrigiorgos, G; Tangutoori, S; Rajiv, K; Sridhar, S

2014-01-01

Purpose: Permanent prostate brachytherapy spacers can be used to deliver sustained doses of radiosentitizing drug directly to the target, in order to enhance the radiation effect. Implantable nanoplatforms for chemo-radiation therapy (INCeRTs) have a maximum drug capacity and can be engineered to control the drug release schedule. The optimal schedule for sensitization during continuous low dose rate irradiation is unknown. This work studies the optimal release schedule of drug for both traditional sensitizers, and those that work by suppressing DNA repair processes. Methods: Six brachytherapy treatment plans were used to model the anatomy, implant geometry and calculate the spatial distribution of radiation dose and drug concentrations for a range of drug diffusion parameters. Three state partial differential equations (cells healthy, damaged or dead) modeled the effect of continuous radiation (radiosensitivities α,β) and cellular repair (time tr) on a cell population. Radiosensitization was modeled as concentration dependent change in α,β or tr which with variable duration under the constraint of fixed total drug release. Average cell kill was used to measure effectiveness. Sensitization by means of both enhanced damage and reduced repair were studied. Results: Optimal release duration is dependent on the concentration of radiosensitizer compared to the saturation concentration (csat) above which additional sensitization does not occur. Long duration drug release when enhancing α or β maximizes cell death when drug concentrations are generally over csat. Short term release is optimal for concentrations below saturation. Sensitization by suppressing repair has a similar though less distinct trend that is more affected by the radiation dose distribution. Conclusion: Models of sustained local radiosensitization show potential to increase the effectiveness of radiation in permanent prostate brachytherapy. INCeRTs with high drug capacity produce the greatest

Photovoltaics Fact Sheet

Energy Technology Data Exchange (ETDEWEB)

None

2016-02-01

This fact sheet is an overview of the Photovoltaics (PV) subprogram at the U.S. Department of Energy SunShot Initiative. The U.S. Department of Energy (DOE)’s Solar Energy Technologies Office works with industry, academia, national laboratories, and other government agencies to advance solar PV, which is the direct conversion of sunlight into electricity by a semiconductor, in support of the goals of the SunShot Initiative. SunShot supports research and development to aggressively advance PV technology by improving efficiency and reliability and lowering manufacturing costs. SunShot’s PV portfolio spans work from early-stage solar cell research through technology commercialization, including work on materials, processes, and device structure and characterization techniques.

FACT facilitates chromatin transcription by RNA polymerases I and III

DEFF Research Database (Denmark)

Birch, Joanna L; Tan, Bertrand C-M; Panov, Kostya I

2009-01-01

Efficient transcription elongation from a chromatin template requires RNA polymerases (Pols) to negotiate nucleosomes. Our biochemical analyses demonstrate that RNA Pol I can transcribe through nucleosome templates and that this requires structural rearrangement of the nucleosomal core particle....... The subunits of the histone chaperone FACT (facilitates chromatin transcription), SSRP1 and Spt16, co-purify and co-immunoprecipitate with mammalian Pol I complexes. In cells, SSRP1 is detectable at the rRNA gene repeats. Crucially, siRNA-mediated repression of FACT subunit expression in cells results...... in a significant reduction in 47S pre-rRNA levels, whereas synthesis of the first 40 nt of the rRNA is not affected, implying that FACT is important for Pol I transcription elongation through chromatin. FACT also associates with RNA Pol III complexes, is present at the chromatin of genes transcribed by Pol III...

Main facts 1995; Faits marquants 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-11-01

This report presents the main facts of the studies carried out by the Direction des Etudes et Recherches (DER) of Electricite de France: new applications of electricity, classical and nuclear thermal power plants, electrical equipment, environment protection, monitoring and plants operations.

Instant-release fractions for the assessment of used nuclear fuel disposal

International Nuclear Information System (INIS)

Garisto, N.C.; Vance, E.R.; Stroes-Gascoyne, S.; Johnson, L.H.

1989-02-01

Quantitative estimates of instant-release fractions for the potential release of radionuclides from used CANDU fuel in an underground disposal vault have been made in terms of probability- density functions, taking variability and uncertainty into account. The radionuclides included in this study are 129 I, 135 Cs, 79 Se, 126 Sn, 99 Tc, 14 C, and 3 H. The probability-density functions are based on experimental data on the short term release of radionuclides upon contact with groundwater, and on a knowledge of the solid-state chemistry of used fuel. They provide source terms for the environmental and safety assessment of used nuclear fuel disposal

Fuels planning: science synthesis and integration; environmental consequences fact sheet 03: structure fires in the wildland-urban interface

Science.gov (United States)

Steve Sutherland

2004-01-01

National Fire Protection Association (NFPA) data indicate that wildfires destroyed approximately 9,000 homes between 1985 and 1994 in the United States. The loss of homes to wildfire has had a significant impact on Federal fire policy. This fact sheet discusses the causes of home ignitions in the wildland-urban interface, home ignition zones, how to reduce home...

Isoniazid release from suppositories compounded with selected bases.

Science.gov (United States)

Hudson, Kristofer C; Asbill, C Scott; Webster, Andrew A

2007-01-01

There is an increasing need for an alternative route of isoniazid adminstration for prophylaxis and treatment of tuberculosis in children. The purpose of this study is to evaluate the in vitro release of isoniazid from extemporaneously compounded isoniazid suppositories with a goal of optimizing the suppository dosage form for this indication. Suppositories were compounded using three different base formulations (cocoa butter, Witepsol H15 Base F, and a combination of polyethylene glycols 3350, 1000, and 400). The release profiles of six compounded suppositories with isoniazid (100 mg) were tested with a United States Pharmacopeial Convention-approved dissolution apparatus. Isoniazid concentrations at predetermined time points were determined using high-performance liquid chromatographic analysis. The results show that drug release from the water-solutble base (mixed polyethylene glycols) was significantly greater than that from the lipophilic bases (cocoa butter and Witepsol H15). The percentage of isoniazid release form the polyethylene glycol suppository formulation (70 +/- 1.4 mg/mL) was greater than that from the cocoa butter (55 +/- 1.1 mg/mL) and Witepsol H15 Base F (18 +/- 0.36 mg/mL) suppository formulations.

The acquisition of dangerous biological materials: Technical facts sheets to assist risk assessments of 46 potential BW agents

Energy Technology Data Exchange (ETDEWEB)

Aceto, Donato Gonzalo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Astuto-Gribble, Lisa M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gaudioso, Jennifer M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2007-11-01

Numerous terrorist organizations have openly expressed interest in producing and deploying biological weapons. However, a limiting factor for many terrorists has been the acquisition of dangerous biological agents, as evidenced by the very few successful instances of biological weapons use compared to the number of documented hoaxes. Biological agents vary greatly in their ability to cause loss of life and economic damage. Some agents, if released properly, can kill many people and cause an extensive number of secondary infections; other agents will sicken only a small number of people for a short period of time. Consequently, several biological agents can potentially be used to perpetrate a bioterrorism attack but few are likely capable of causing a high consequence event. It is crucial, from a US national security perspective, to more deeply understand the likelihood that terrorist organizations can acquire the range of these agents. Few studies have attempted to comprehensively compile the technical information directly relevant to the acquisition of dangerous bacteria, viruses and toxins. In this report, technical fact sheets were assembled for 46 potentially dangerous biological agents. Much of the information was taken from various research sources which could ultimately and significantly expedite and improve bioterrorism threat assessments. By systematically examining a number of specific agent characteristics included in these fact sheets, it may be possible to detect, target, and implement measures to thwart future terrorist acquisition attempts. In addition, the information in these fact sheets may be used as a tool to help laboratories gain a rudimentary understanding of how attractive a method laboratory theft is relative to other potential acquisition modes.

16 CFR 460.15 - How installers must handle fact sheets.

Science.gov (United States)

2010-01-01

... ADVERTISING OF HOME INSULATION § 460.15 How installers must handle fact sheets. If you are an installer, you... from you, you must show them the fact sheet(s) for the type(s) of insulation they want. You can decide...

Fission product release from TRIGA-LEU reactor fuels

International Nuclear Information System (INIS)

Baldwin, N.L.; Foushee, F.C.; Greenwood, J.S.

1980-01-01

Due to present international concerns over nuclear proliferation, TRIGA reactor fuels will utilize only low-enriched uranium (LEU) (enrichment <20%). This requires increased total uranium loading per unit volume of fuel in order to maintain the appropriate fissile loading. Tests were conducted to determine the fractional release of gaseous and metallic fission products from typical uranium-zirconium hydride TRIGA fuels containing up to 45 wt-% uranium. These tests, performed in late 1977 and early 1978, were similar to those conducted earlier on TRIGA fuels with 8.5 wt-% U. Fission gas release measurements were made on prototypic specimens from room temperature to 1100 deg. C in the TRIGA King Furnace Facility. The fuel specimens were irradiated in the TRIGA reactor at a low power level. The fractional releases of the gaseous nuclides of krypton and xenon were measured under steady-state operating conditions. Clean helium was used to sweep the fission gases released during irradiation from the furnace into a standard gas collection trap for gamma counting. The results of these tests on TRIGA-LEU fuel agree well with data from the similar, earlier tests on TRIGA fuel. The correlation used to calculate the release of fission products from 8.5 wt-% U TRIGA fuel applies equally well for U contents up to 45 wt-%. (author)

Invasive plants and enemy release: evolution of trait means and trait correlations in Ulex europaeus.

Science.gov (United States)

Hornoy, Benjamin; Tarayre, Michèle; Hervé, Maxime; Gigord, Luc; Atlan, Anne

2011-01-01

Several hypotheses that attempt to explain invasive processes are based on the fact that plants have been introduced without their natural enemies. Among them, the EICA (Evolution of Increased Competitive Ability) hypothesis is the most influential. It states that, due to enemy release, exotic plants evolve a shift in resource allocation from defence to reproduction or growth. In the native range of the invasive species Ulex europaeus, traits involved in reproduction and growth have been shown to be highly variable and genetically correlated. Thus, in order to explore the joint evolution of life history traits and susceptibility to seed predation in this species, we investigated changes in both trait means and trait correlations. To do so, we compared plants from native and invaded regions grown in a common garden. According to the expectations of the EICA hypothesis, we observed an increase in seedling height. However, there was little change in other trait means. By contrast, correlations exhibited a clear pattern: the correlations between life history traits and infestation rate by seed predators were always weaker in the invaded range than in the native range. In U. europaeus, the role of enemy release in shaping life history traits thus appeared to imply trait correlations rather than trait means. In the invaded regions studied, the correlations involving infestation rates and key life history traits such as flowering phenology, growth and pod density were reduced, enabling more independent evolution of these key traits and potentially facilitating local adaptation to a wide range of environments. These results led us to hypothesise that a relaxation of genetic correlations may be implied in the expansion of invasive species.

Invasive plants and enemy release: evolution of trait means and trait correlations in Ulex europaeus.

Directory of Open Access Journals (Sweden)

Benjamin Hornoy

Full Text Available Several hypotheses that attempt to explain invasive processes are based on the fact that plants have been introduced without their natural enemies. Among them, the EICA (Evolution of Increased Competitive Ability hypothesis is the most influential. It states that, due to enemy release, exotic plants evolve a shift in resource allocation from defence to reproduction or growth. In the native range of the invasive species Ulex europaeus, traits involved in reproduction and growth have been shown to be highly variable and genetically correlated. Thus, in order to explore the joint evolution of life history traits and susceptibility to seed predation in this species, we investigated changes in both trait means and trait correlations. To do so, we compared plants from native and invaded regions grown in a common garden. According to the expectations of the EICA hypothesis, we observed an increase in seedling height. However, there was little change in other trait means. By contrast, correlations exhibited a clear pattern: the correlations between life history traits and infestation rate by seed predators were always weaker in the invaded range than in the native range. In U. europaeus, the role of enemy release in shaping life history traits thus appeared to imply trait correlations rather than trait means. In the invaded regions studied, the correlations involving infestation rates and key life history traits such as flowering phenology, growth and pod density were reduced, enabling more independent evolution of these key traits and potentially facilitating local adaptation to a wide range of environments. These results led us to hypothesise that a relaxation of genetic correlations may be implied in the expansion of invasive species.

Release of radon contaminants from Yucca Mountain: The role of buoyancy driven flow

International Nuclear Information System (INIS)

Sullivan, T.M.; Pescatore, C.

1994-02-01

The potential for the repository heat source to promote buoyancy driven flow and thereby cause release of radon gas out of Yucca Mountain has been examined through a critical review of the theoretical and experimental studies of this process. The review indicates that steady-state buoyancy enhanced release of natural radon and other contaminant gases should not be a major concern at Yucca Mountain. Barometric pumping and wind pumping are identified as two processes that will have a potentially greater effect on surface releases of gases

The state of amphibians in the United States

Science.gov (United States)

Muths, E.; Adams, M.J.; Grant, E.H.C.; Miller, D.; Corn, P.S.; Ball, L.C.

2012-01-01

More than 25 years ago, scientists began to identify unexplained declines in amphibian populations around the world. Much has been learned since then, but amphibian declines have not abated and the interactions among the various threats to amphibians are not clear. Amphibian decline is a problem of local, national, and international scope that can affect ecosystem function, biodiversity, and commerce. This fact sheet provides a snapshot of the state of the amphibians and introduces examples to illustrate the range of issues in the United States.

D.E.R. 91 main facts

International Nuclear Information System (INIS)

Schmidt, N.

1991-01-01

This report presents the main facts of the studies carried out by the Direction des Etudes et Recherches (DER) of Electricite de France: New applications of electricity, classical and nuclear thermal power plants, electrical equipment, environment protection, network analysis, information and informatic equipment

D.E.R. 92 - Main facts

International Nuclear Information System (INIS)

1992-01-01

This report presents the main facts of the studies carried out by the Direction des Etudes et Recherches (DER) of Electricite de France: new applications of electricity, classical and nuclear thermal power plants, electrical equipment, environment protection, network analysis, information and informatic equipment

Physical Therapy and Occupational Therapy: Suggested Readings [and] Physical Therapy: Supply/Demand--Some Facts [and] Occupational Therapy: Supply and Demand--Some Facts. Information on Personnel Supply and Demand.

Science.gov (United States)

National Clearinghouse for Professions in Special Education, Reston, VA.

Brought together are two fact sheets on the supply of and demand for physical therapists and occupational therapists. The fact sheets cite statistical data from the National Easter Seal Society, the American Physical Therapy Association, and the American Occupational Therapy Association. The cited facts focus on the need to recruit and retain…

Dynamic Management of Releases for the Delaware River Basin using NYC's Operations Support Tool

Science.gov (United States)

Weiss, W.; Wang, L.; Murphy, T.; Muralidhar, D.; Tarrier, B.

2011-12-01

The New York City Department of Environmental Protection (DEP) has initiated design of an Operations Support Tool (OST), a state-of-the-art decision support system to provide computational and predictive support for water supply operations and planning. Using an interim version of OST, DEP and the New York State Department of Environmental Conservation (DEC) have developed a provisional, one-year Delaware River Basin reservoir release program to succeed the existing Flexible Flow Management Program (FFMP) which expired on May 31, 2011. The FFMP grew out of the Good Faith Agreement of 1983 among the four Basin states (New York, New Jersey, Pennsylvania, and Delaware) that established modified diversions and flow targets during drought conditions. It provided a set of release schedules as a framework for managing diversions and releases from New York City's Delaware Basin reservoirs in order to support multiple objectives, including water supply, drought mitigation, flood mitigation, tailwaters fisheries, main stem habitat, recreation, and salinity repulsion. The provisional program (OST-FFMP) defines available water based on current Upper Delaware reservoir conditions and probabilistic forecasts of reservoir inflow. Releases are then set based on a set of release schedules keyed to the water availability. Additionally, OST-FFMP attempts to provide enhanced downstream flood protection by making spill mitigation releases to keep the Delaware System reservoirs at a seasonally varying conditional storage objective. The OST-FFMP approach represents a more robust way of managing downstream releases, accounting for predicted future hydrologic conditions by making more water available for release when conditions are forecasted to be wet and protecting water supply reliability when conditions are forecasted to be dry. Further, the dynamic nature of the program allows the release decision to be adjusted as hydrologic conditions change. OST simulations predict that this

Influence of medical journal press releases on the quality of associated newspaper coverage: retrospective cohort study.

Science.gov (United States)

Schwartz, Lisa M; Woloshin, Steven; Andrews, Alice; Stukel, Therese A

2012-01-27

To determine whether the quality of press releases issued by medical journals can influence the quality of associated newspaper stories. Retrospective cohort study of medical journal press releases and associated news stories. We reviewed consecutive issues (going backwards from January 2009) of five major medical journals (Annals of Internal Medicine, BMJ, Journal of the National Cancer Institute, JAMA, and New England Journal of Medicine) to identify the first 100 original research articles with quantifiable outcomes and that had generated any newspaper coverage (unique stories ≥100 words long). We identified 759 associated newspaper stories using Lexis Nexis and Factiva searches, and 68 journal press releases using Eurekalert and journal website searches. Two independent research assistants assessed the quality of journal articles, press releases, and a stratified random sample of associated newspaper stories (n=343) by using a structured coding scheme for the presence of specific quality measures: basic study facts, quantification of the main result, harms, and limitations. Proportion of newspaper stories with specific quality measures (adjusted for whether the quality measure was present in the journal article's abstract or editor note). We recorded a median of three newspaper stories per journal article (range 1-72). Of 343 stories analysed, 71% reported on articles for which medical journals had issued press releases. 9% of stories quantified the main result with absolute risks when this information was not in the press release, 53% did so when it was in the press release (relative risk 6.0, 95% confidence interval 2.3 to 15.4), and 20% when no press release was issued (2.2, 0.83 to 6.1). 133 (39%) stories reported on research describing beneficial interventions. 24% mentioned harms (or specifically declared no harms) when harms were not mentioned in the press release, 68% when mentioned in the press release (2.8, 1.1 to 7.4), and 36% when no press release

Water: Facts without Myths

Directory of Open Access Journals (Sweden)

Marc Henry

2009-08-01

Full Text Available Among all the chemical substances available in the universe, water, with its deceptively simple formula H2O, is the most discussed subject either in science or in philosophy [1]. If you are not convinced by this affirmation, a little experiment at no cost may help you change your mind. Just open your favorite web browser and type the word “water” in any search engine. When I have done that using Google, the number of hits was about 682,000,000 (please do not try to read all the pages. In fact, the only words that seem to beat water at this little game are “air” (770,000,000 hits with Google and 3,120,000,000 with Yahoo, and “food” (689,000,000 hits with Google and 3,820,000,000 with Yahoo. Of course this should not be a surprise, as breathing, eating, drinking just mean that you are a living entity. In fact extending the water search to “eau” (French, “wasser” (German, “agua” (Spanish, Portuguese and “acqua” (Italian leads to 978,900,000 hits under Google and 3,426,000,000 hits under Yahoo, showing now that water is about as important as food. After all, as everybody knows, “water is life”, and do we really have to read about one billion documents to know at least what water really is? [...

Proving Opacity of Transactional Memory with Early Release

Directory of Open Access Journals (Sweden)

Siek Konrad

2015-12-01

Full Text Available Transactional Memory (TM is an alternative way of synchronizing concurrent accesses to shared memory by adopting the abstraction of transactions in place of low-level mechanisms like locks and barriers. TMs usually apply optimistic concurrency control to provide a universal and easy-to-use method of maintaining correctness. However, this approach performs a high number of aborts in high contention workloads, which can adversely affect performance. Optimistic TMs can cause problems when transactions contain irrevocable operations. Hence, pessimistic TMs were proposed to solve some of these problems. However, an important way of achieving efficiency in pessimistic TMs is to use early release. On the other hand, early release is seemingly at odds with opacity, the gold standard of TM safety properties, which does not allow transactions to make their state visible until they commit. In this paper we propose a proof technique that makes it possible to demonstrate that a TM with early release can be opaque as long as it prevents inconsistent views.

Peptide secreted by human alveolar macrophages releases neutrophil granule contents

International Nuclear Information System (INIS)

MacArthur, C.K.; Miller, E.J.; Cohen, A.B.

1987-01-01

A monoclonal antibody was developed against an 8000-kDa enzyme-releasing peptide (ERP) released from human alveolar macrophages. ERP was isolated on an immunoaffinity column containing the antibody bound to staphylococcal protein A-Sepharose, and by autoradiography. Release of ERP from the macrophages is not changed by plastic adherence, phagocytosis, calcium ionophore, or phorbol esters. The peptide was not antigenically similar to interferon-γ, tumor necrosis factor, or interleukin lα or 1β. The release of constituents from azurophilic and specific granules was the main identified biologic function of ERP. ERP was a more effective secretagogue in the untreated neutrophils and f-met-leu-phe was more effective in the cytochalasin B-treated neutrophils. Absorption of ERP from macrophage-conditioned medium removed a small amount of the chemotactic activity; however, the immunopurified peptide was not chemotactic or chemokinetic for neutrophils, and at high concentrations, it suppressed base line chemokinesis. Treatment of washed macrophages with trypsin released active ERP of approximately the same m.w. of spontaneously secreted ERP. These studies showed that human alveolar macrophages release a peptide which is a secretagogue for human neutrophils under conditions which may be encountered in the lungs during certain disease states. Proteolytic enzymes which are free in the lungs may release the peptide and lead to the secretion of neutrophil enzymes

Carbon-Based Solid-State Calcium Ion-Selective Microelectrode and Scanning Electrochemical Microscopy: A Quantitative Study of pH-Dependent Release of Calcium Ions from Bioactive Glass.

Science.gov (United States)

Ummadi, Jyothir Ganesh; Downs, Corey J; Joshi, Vrushali S; Ferracane, Jack L; Koley, Dipankar

2016-03-15

Solid-state ion-selective electrodes are used as scanning electrochemical microscope (SECM) probes because of their inherent fast response time and ease of miniaturization. In this study, we report the development of a solid-state, low-poly(vinyl chloride), carbon-based calcium ion-selective microelectrode (Ca(2+)-ISME), 25 μm in diameter, capable of performing an amperometric approach curve and serving as a potentiometric sensor. The Ca(2+)-ISME has a broad linear response range of 5 μM to 200 mM with a near Nernstian slope of 28 mV/log[a(Ca(2+))]. The calculated detection limit for Ca(2+)-ISME is 1 μM. The selectivity coefficients of this Ca(2+)-ISME are log K(Ca(2+),A) = -5.88, -5.54, and -6.31 for Mg(2+), Na(+), and K(+), respectively. We used this new type of Ca(2+)-ISME as an SECM probe to quantitatively map the chemical microenvironment produced by a model substrate, bioactive glass (BAG). In acidic conditions (pH 4.5), BAG was found to increase the calcium ion concentration from 0.7 mM ([Ca(2+)] in artificial saliva) to 1.4 mM at 20 μm above the surface. In addition, a solid-state dual SECM pH probe was used to correlate the release of calcium ions with the change in local pH. Three-dimensional pH and calcium ion distribution mapping were also obtained by using these solid-state probes. The quantitative mapping of pH and Ca(2+) above the BAG elucidates the effectiveness of BAG in neutralizing and releasing calcium ions in acidic conditions.

A proposal for investment recovery of FACTS devices in deregulated electricity markets

International Nuclear Information System (INIS)

Mithulananthan, Nadarajah; Acharya, Naresh

2007-01-01

The paper presents a methodology to quantify the benefits, in terms of monetary values, of FACTS devices when used in deregulated electricity market for congestion management. The proposed methodology is used in the proposal for investment recovery of FACTS devices. Despite the long history of development and mature technology, the practical installations of FACTS devices are still limited. The main reasons for few installations are high investment cost and lack of viable measures to quantify the long list of benefits offered by FACTS device. In this respect, the methodology proposed in the paper provides a promising solution. The proposed methodology is based on establishing pricing schemes with and without FACTS devices using OPF formulation. The volume of market with FACTS devices and the increase in surplus due to them forms the basis of quantifying their benefits. The pricing scheme does not destroy the incentive effect in short run and also makes possible the provision of merchant FACTS. The proposed concept was tested and validated with TCSC in five-bus test system. Result shows that, when TCSC is used to relieve congestion in the system and the investment on TCSC can be recovered. (author)

Florida Atlantic Coast Telemetry (FACT) Array: A Working Partnership

Science.gov (United States)

Scheidt, Douglas; Ault, Erick; Ellis, Robert D.; Gruber, Samuel; Iafrate, Joseph; Kalinowsky, Chris; Kessel, Steven; Reyier, Eric; Snyder, David; Watwood, Stephanie;

Maximally Entangled Multipartite States: A Brief Survey

International Nuclear Information System (INIS)

Enríquez, M; Wintrowicz, I; Życzkowski, K

2016-01-01

The problem of identifying maximally entangled quantum states of a composite quantum systems is analyzed. We review some states of multipartite systems distinguished with respect to certain measures of quantum entanglement. Numerical results obtained for 4-qubit pure states illustrate the fact that the notion of maximally entangled state depends on the measure used. (paper)

Gastrin release: Antrum microdialysis reveals a complex neural control

DEFF Research Database (Denmark)

Ericsson, P; Håkanson, R; Rehfeld, Jens F.

2010-01-01

in both serum and microdialysate. Food intake induced a 2- to 3-fold increase in serum gastrin, while gastrin in antral microdialysate increased 10- to 15-fold. In unilaterally vagotomized rats (fasted, 3 days post-op.), food evoked a prompt peak gastrin release followed by a gradual decline on the intact......We used microdialysis to monitor local gastrin release in response to food, acid blockade and acute vagal excitation. For the first time, gastrin release has been monitored continuously in intact conscious rats in a physiologically relevant experimental setting in a fashion that minimizes...... in serum regardless of the prandial state. The rats were conscious during microdialysis except when subjected to electrical vagal stimulation. Acid blockade (omeprazole treatment of freely fed rats for 4 days), or bilateral sectioning of the abdominal vagal trunks (fasted, 3 days post-op.), raised...

NuclearFACTS: public engagement about the impacts of nuclear research

Energy Technology Data Exchange (ETDEWEB)

Dalzell, M.T.J.; Alexander, R.N.; Main, M.G., E-mail: matthew.dalzell@fedorukcentre.ca [Sylvia Fedoruk Canadian Centre for Nuclear Innovation, Saskatoon, SK, (Canada)

2015-07-01

The Forum for Accountability and Communities Talking nuclear Science - nuclearFACTS - is a cornerstone of the Sylvia Fedoruk Canadian Centre for Nuclear Innovation's efforts to engage the people of Saskatchewan in evidence-based conversations about the impacts of the nuclear research, development and training activities supported by the Fedoruk Centre. The second annual nuclearFACTS public colloquium was held 20 November 2014, and featured the participation of 16 research projects. This paper discusses the continued development of the nuclearFACTS concept and its role in the Fedoruk Centre's upstream engagement efforts. (author)

EU AND GLOBALIZATION: SOME STYLIZED FACTS

Directory of Open Access Journals (Sweden)

Scamuffa Domenico

2009-05-01

Full Text Available Most of the people all over the world claim that globalization is a result of dynamic interactions between economic, technological, social and political factors. The aim of this paper is to document some stylized facts on this phenomenon in order to take

Moving Facts in an Arctic field

DEFF Research Database (Denmark)

Hastrup, Kirsten Blinkenberg; Flora, Janne; Andersen, Astrid Oberborbeck

2016-01-01

, and an engagement with other disciplinary practices. The gain of our cross-disciplinary experiment was therefore not only to know more about the makings of a particular landscape in a multi-disciplinary perspective, but also to understand how anthropology makes sense of inherently moving facts....

Data analysis unveils a new stylized fact in foreign currency markets

Science.gov (United States)

Nacher, J. C.; Ochiai, T.

2012-09-01

The search for stylized facts (i.e., simplified empirical facts) is of capital importance in econophysics because the stylized facts constitute the experimental empirical body on which theories and models should be tested. At the moment they are too few and this is an important limitation to the progress in the field. In this work, we unveil a new stylized fact, which consists of resistance effect and breaking-acceleration effect that implicitly requires a long memory feature in price movement. By analyzing a vast amount of historical data, we demonstrate that the financial market tends to exceed a past (historical) extreme price less often than expected by a classic short-memory model (e.g., Black-Scholes model). We call it resistance effect. However, when the market does it, we predict that the average volatility at that time point will be much higher (accelerates more). It means, in average, volatility accelerates more when the price breaks the highest (lowest) value. We refer to this as breaking-acceleration effect. These observed empirical facts are actually an effect which may arise from technical trading and psychological effects. Taken together, these results indicate that, beyond the predictive capability of this unveiled stylized fact, traditional short-memory models do not faithfully capture the market dynamics.

Characterization of unsaturated fatty acid sustained-release microspheres for long-term algal inhibition.

Science.gov (United States)

Ni, Lixiao; Jie, Xiaoting; Wang, Peifang; Li, Shiyin; Hu, Shuzhen; Li, Yiping; Li, Yong; Acharya, Kumud

2015-02-01

The unsaturated fatty acid (linoleic acid) sustained-release microspheres were prepared with linoleic acid (LA) using alginate-chitosan microcapsule technology. These LA sustained-release microspheres had a high encapsulation efficiency (up to 62%) tested by high performance liquid chromatography with a photo diode array. The dry microspheres were characterized by a scanning electron microscope, X-ray diffraction measurement, dynamic thermogravimetric analysis and Fourier transform infrared spectral analysis. The results of characterization showed that the microspheres had good thermal stability (decomposition temperature of 236°C), stable and temperature independent release properties (release time of more than 40 d). Compared to direct dosing of LA, LA sustained-released microspheres could inhibit Microcystis aeruginosa growth to the non-growth state. The results of this study suggested that the LA sustained-release microspheres may be a potential candidate for algal inhibition. Copyright © 2014 Elsevier Ltd. All rights reserved.

THE POPULATION HEALTH STATE IN THE UPPER BAZIN OF MOLDOVIAN BISTRITA AND ITS LIFESTYLE

Directory of Open Access Journals (Sweden)

Alexandrina D. CRUCEANU

2014-06-01

Full Text Available It is an unanimously accepted fact that the communities’ health state in general and of the individual’s in particular is determined and influenced by a cumulus of physico-geographical factors (natural and human, factors more difficult to quantify as a society’s structure and functionality is more complex. The starting hypothesis of our study focused on identifying the existence/absence of a causality connection between the lifestyle of the communities in the upper basin of the Moldavian Bistrita (Vatra Dornei town and other ten rural areas and their health state. If we can’t control the release of a storm, drought, landslide, volcano eruption, tsunami, etc., we can’t say the same thing about our decisions regarding nutrition, weight control and maintenance, physical and psychical hygiene, the quality of interpersonal relationships, continuous self-development, the attitude towards stressful events, etc., aspects upon which we can fortunately interfere. Our case study confirms once again that the healthy persons’ lifestyle is significantly different from that of a person suffering from different medical affections.

Spina Bifida. Fact Sheet = Espina Bifida. Hojas Informativas Sobre Discapacidades.

Science.gov (United States)

National Information Center for Children and Youth with Disabilities, Washington, DC.

This fact sheet offers definitions of the three types of spina bifida (spina bifida occulta, meningocele, and myelomeningocele), outlines their incidence, describes characteristics of individuals with spina bifida, and reviews educational implications. The fact sheet discusses the need for many children with myelomeningocele to learn to manage…

Facing the facts: the suspension of a design requirement applicable to nuclear power reactor effluents

International Nuclear Information System (INIS)

Amado, Valeria; Biaggio, Alfredo; Canoba, Analia; Curti, Adriana

2008-01-01

A design requirement aimed at limiting the discharge of globally dispersed long-lived radionuclides released by nuclear power reactors was in force in Argentine since 1979 till recently. The practical results of such regulatory measure was the need to retain C-14 in the PHWR under construction, as well as in furniture heavy water reactors to be built in the country. This paper explains the basis of such requirement, which was formulated as a collective dose constraint per unit of energy generated, and the main assumptions that triggered it. The differences between the assumptions made at the time and the reality of nuclear power generation at the beginning of the 21 st century, as well as their implications in relation to the requirement are described, including the Suess effect and its impact in the total dose due to C-14. Finally, the facts that made no longer reasonable to keep in force the above mentioned requirement are presented. (author)

Metal-organic framework tethering PNIPAM for ON-OFF controlled release in solution.

Science.gov (United States)

Nagata, Shunjiro; Kokado, Kenta; Sada, Kazuki

2015-05-21

A smart metal-organic framework (MOF) exhibiting controlled release was achieved by modification with a thermoresponsive polymer (PNIPAM) via a surface-selective post-synthetic modification technique. Simple temperature variation readily switches "open" (lower temperature) and "closed" (higher temperature) states of the polymer-modified MOF through conformational change of PNIPAM grafted onto the MOF, resulting in controlled release of the included guest molecules such as resorufin, caffeine, and procainamide.

More Cancer Types - SEER Cancer Stat Facts

Science.gov (United States)

Cancer Statistical Fact Sheets are summaries of common cancer types developed to provide an overview of frequently-requested cancer statistics including incidence, mortality, survival, stage, prevalence, and lifetime risk.

Contribution of Content Knowledge and Learning Ability to the Learning of Facts.

Science.gov (United States)

Kuhara-Kojima, Keiko; Hatano, Giyoo

1991-01-01

In 3 experiments, 1,598 Japanese college students were examined concerning the learning of facts in 2 content domains, baseball and music. Content knowledge facilitated fact learning only in the relevant domain; learning ability facilitated fact learning in both domains. Effects of content knowledge and learning ability were additive. (SLD)

Subtle Implicit Language Facts Emerge from the Functions of Constructions.

Science.gov (United States)

Goldberg, Adele E

2015-01-01

Much has been written about the unlikelihood of innate, syntax-specific, universal knowledge of language (Universal Grammar) on the grounds that it is biologically implausible, unresponsive to cross-linguistic facts, theoretically inelegant, and implausible and unnecessary from the perspective of language acquisition. While relevant, much of this discussion fails to address the sorts of facts that generative linguists often take as evidence in favor of the Universal Grammar Hypothesis: subtle, intricate, knowledge about language that speakers implicitly know without being taught. This paper revisits a few often-cited such cases and argues that, although the facts are sometimes even more complex and subtle than is generally appreciated, appeals to Universal Grammar fail to explain the phenomena. Instead, such facts are strongly motivated by the functions of the constructions involved. The following specific cases are discussed: (a) the distribution and interpretation of anaphoric one, (b) constraints on long-distance dependencies, (c) subject-auxiliary inversion, and (d) cross-linguistic linking generalizations between semantics and syntax.

43 CFR 414.3 - Storage and Interstate Release Agreements.

Science.gov (United States)

2010-10-01

... any other provisions that the parties deem appropriate. (b) How to address financial considerations. The Secretary will not execute an agreement that has adverse impacts on the financial interests of the... Release Agreement on the financial interests of the United States. Based on the consideration of the...

Hydraulic running and release tool with mechanical emergency release

International Nuclear Information System (INIS)

Baker, S.F.

1991-01-01

This patent describes a setting tool for connection in a well string to position a tubular member in a well bore. It comprises: a mandrel adapted to be connected to the well string; an outer sleeve surrounding the mandrel and releasably secured thereto; a latch nut releasably connected to the outer sleeve; piston means sealingly engaging the mandrel; shear means releasably securing the piston to the latch nut to maintain the latch nut releasably connected to the tubular member; the mandrel having port means for conducting fluid pressure from the well string to release the piston means from and the latch nut; cooperating engageable surfaces on the piston and latch nut to reengage them together after the piston moves a predetermined longitudinal distance relative to the latch nut; and additional cooperating engageable surfaces on the latch nut and the outer sleeve which are engageable when the piston and engaged latch nut are moved a predetermined additional longitudinal distance by fluid pressure to secure the engaged piston and latch nut with the outer sleeve for retrieval along with the mandrel from the well bore

78 FR 48156 - Update to An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the...

Science.gov (United States)

2013-08-07

... Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the United States for the Years... document entitled, Update to An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in... the report: An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the United...

International nuclear fuel cycle fact book

Energy Technology Data Exchange (ETDEWEB)

Leigh, I.W.

1988-01-01

As the US Department of Energy (DOE) and DOE contractors have become increasingly involved with other nations in nuclear fuel cycle and waste management cooperative activities, a need has developed for a ready source or information concerning foreign fuel cycle programs, facilities, and personnel. This Fact Book was compiled to meet that need. The information contained has been obtained from nuclear trade journals and newsletters; reports of foreign visits and visitors; CEC, IAEA, and OECD/NEA activities reports; proceedings of conferences and workshops; and so forth. Sources do not agree completely with each other, and the data listed herein does not reflect any one single source but frequently is consolidation/combination of information. Lack of space as well as the intent and purpose of the Fact Book limit the given information to that pertaining to the Nuclear Fuel Cycle and to data considered of primary interest or most helpful to the majority of users.

International nuclear fuel cycle fact book

International Nuclear Information System (INIS)

Leigh, I.W.

1988-01-01

As the US Department of Energy (DOE) and DOE contractors have become increasingly involved with other nations in nuclear fuel cycle and waste management cooperative activities, a need has developed for a ready source or information concerning foreign fuel cycle programs, facilities, and personnel. This Fact Book was compiled to meet that need. The information contained has been obtained from nuclear trade journals and newsletters; reports of foreign visits and visitors; CEC, IAEA, and OECD/NEA activities reports; proceedings of conferences and workshops; and so forth. Sources do not agree completely with each other, and the data listed herein does not reflect any one single source but frequently is consolidation/combination of information. Lack of space as well as the intent and purpose of the Fact Book limit the given information to that pertaining to the Nuclear Fuel Cycle and to data considered of primary interest or most helpful to the majority of users

International nuclear fuel cycle fact book

International Nuclear Information System (INIS)

Leigh, I.W.; Lakey, L.T.; Schneider, K.J.; Silviera, D.J.

1987-01-01

As the US Department of Energy (DOE) and DOE contractors have become increasingly involved with other nations in nuclear fuel cycle and waste management cooperative activities, a need has developed for a ready source of information concerning foreign fuel cycle programs, facilities, and personnel. This Fact Book was compiled to meet that need. The information contained has been obtained from nuclear trade journals and newsletters; reports of foreign visits and visitors; CEC, IAEA, and OECD/NEA activities reports; proceedings of conferences and workshops; and so forth. Sources do not agree completely with each other, and the data listed herein does not reflect any one single source but frequently is a consolidation/combination of information. Lack of space as well as the intent and purpose of the Fact Book limit the given information to that pertaining to the Nuclear Fuel Cycle and to data considered of primary interest or most helpful to the majority of users

Meltable magnetic biocomposites for controlled release

Energy Technology Data Exchange (ETDEWEB)

Müller, R., E-mail: robert.mueller@ipht-jena.de [Leibniz Institute of Photonic Technology (IPHT), P.O.B. 100239, Jena, D-07702 Germany (Germany); Zhou, M. [Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstrasse 10, Jena, D-07743 Germany (Germany); Dellith, A. [Leibniz Institute of Photonic Technology (IPHT), P.O.B. 100239, Jena, D-07702 Germany (Germany); Liebert, T.; Heinze, T. [Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstrasse 10, Jena, D-07743 Germany (Germany)

2017-06-01

New biocompatible composites with adjustable melting point in the range of 30–140 °C, consisting of magnetite nanoparticles embedded into a matrix of meltable dextran fatty acid ester are presented which can be softened under an induced alternating magnetic field (AMF). The chosen thermoplastic magnetic composites have a melting range close to human body temperature and can be easily shaped into disk or coating film under melting. The composite disks were loaded with green fluorescent protein (GFP) as a model protein. Controlled release of the protein was realized with high frequent alternating magnetic field of 20 kA/m at 400 kHz. These results showed that under an AMF the release of GFP from magnetic composite was accelerated compared to the control sample without exposure to AMF. Furthermore a texturing of particles in the polymer matrix by a static magnetic field was investigated. - Highlights: • Thermoplastic biocomposite are prepared from dextran ester and magnetite particles. • The composite can be heated by an AC magnetic field above the melting temperature. • In molten state texturing of particles is possible and improves the heating ability. • The biopolymer could be used as a remote controlled matrix for protein release.

Evidence for endogenous opioid release in the amygdala during positive emotion.

Science.gov (United States)

Koepp, M J; Hammers, A; Lawrence, A D; Asselin, M C; Grasby, P M; Bench, C J

2009-01-01

Endogenous opioid release has been linked to relief from aversive emotional memories, thereby promoting a euphoric state and subsequent interactions towards social stimuli resulting in the formation of social preferences. However, this theory remains controversial. Using positron emission tomography and [(11)C]diprenorphine (DPN) in healthy volunteers, we found significantly reduced DPN binding to opioid receptor in the hippocampus during positive mood induction compared to neutral mood. Furthermore, the magnitude of positive mood change correlated negatively with DPN binding in the amygdala bilaterally. Our finding of reduced DPN binding is consistent with increased release of endogenous opioids, providing direct evidence that localised release of endogenous opioids is involved in the regulation of positive emotion in humans.

Electron Beam Processing of Polymers: Facts and Opportunities

International Nuclear Information System (INIS)

Gielenz, G.

2006-01-01

Electron Beam (EB) processing of polymers is a well established and mature technology in a multitude of industrial polymer applications for more than 40 years. Constant research effort in combination with emerging tailored EB process technologies, have led to numerous new (niche) applications and products within the past decade. Nonetheless, and despite the fact, that nowadays a large variety of EB and related process equipment is readily available for use by the respective industries, EB processing of polymers still takes up only a small niche in comparison to the overall polymer business. In this lecture the author attempts to present a short overview on the current industrial established and emerging radiation processing applications and the related EB equipment suppliers. Then some selected plastics business facts and figures with a forecast of the global plastics consumption situation up to 2010 will be shown. As a conclusion from these facts, some comments will be deduced, regarding the future potential, attractiveness and economical relevance of irradiation processing technologies in present day competitive global markets

Nanodiamond-based injectable hydrogel for sustained growth factor release: Preparation, characterization and in vitro analysis.

Science.gov (United States)

Pacelli, Settimio; Acosta, Francisca; Chakravarti, Aparna R; Samanta, Saheli G; Whitlow, Jonathan; Modaresi, Saman; Ahmed, Rafeeq P H; Rajasingh, Johnson; Paul, Arghya

2017-08-01

Nanodiamonds (NDs) represent an emerging class of carbon nanomaterials that possess favorable physical and chemical properties to be used as multifunctional carriers for a variety of bioactive molecules. Here we report the synthesis and characterization of a new injectable ND-based nanocomposite hydrogel which facilitates a controlled release of therapeutic molecules for regenerative applications. In particular, we have formulated a thermosensitive hydrogel using gelatin, chitosan and NDs that provides a sustained release of exogenous human vascular endothelial growth factor (VEGF) for wound healing applications. Addition of NDs improved the mechanical properties of the injectable hydrogels without affecting its thermosensitive gelation properties. Biocompatibility of the generated hydrogel was verified by in vitro assessment of apoptotic gene expressions and anti-inflammatory interleukin productions. NDs were complexed with VEGF and the inclusion of this complex in the hydrogel network enabled the sustained release of the angiogenic growth factor. These results suggest for the first time that NDs can be used to formulate a biocompatible, thermosensitive and multifunctional hydrogel platform that can function both as a filling agent to modulate hydrogel properties, as well as a delivery platform for the controlled release of bioactive molecules and growth factors. One of the major drawbacks associated with the use of conventional hydrogels as carriers of growth factors is their inability to control the release kinetics of the loaded molecules. In fact, in most cases, a burst release is inevitable leading to diminished therapeutic effects and unsuccessful therapies. As a potential solution to this issue, we hereby propose a strategy of incorporating ND complexes within an injectable hydrogel matrix. The functional groups on the surface of the NDs can establish interactions with the model growth factor VEGF and promote a prolonged release from the polymer network

Hazards to nuclear plants from off-site release of toxic vapors

International Nuclear Information System (INIS)

Hornyik, K.

1976-01-01

A method for the assessment of risk involved in shipping toxic compounds past nuclear power plants uses a postulated chain of events, starting with a traffic accident causing instantaneous release of the compound as vapor, and leading to incapacitation of control operators in the nuclear plant, described by deterministic and statistical models as appropriate to the respective event. Statistical treatment of relevant atmospheric conditions is a major improvement over more conservative assumptions commonly made in current analyses of this problem. Consequently, one obtains a substantial reduction in the estimated risk expressed in usual terms of the annual probability of an unacceptable event, in spite of the fact that no credit is taken for protective measures other than potential control room isolation

Recent facts about photovoltaics in Germany

International Nuclear Information System (INIS)

Wirth, Harry

2015-01-01

Germany is leaving the age of fossil fuel behind. In building a sustainable energy future, photovoltaics is going to have an important role. The following summary consists of the most recent facts, figures and findings and shall assist in forming an overall assessment of the photovoltaic expansion in Germany.

Large scientific releases

International Nuclear Information System (INIS)

Pongratz, M.B.

1981-01-01

The motivation for active experiments in space is considered, taking into account the use of active techniques to obtain a better understanding of the natural space environment, the utilization of the advantages of space as a laboratory to study fundamental plasma physics, and the employment of active techniques to determine the magnitude, degree, and consequences of artificial modification of the space environment. It is pointed out that mass-injection experiments in space plasmas began about twenty years ago with the Project Firefly releases. Attention is given to mass-release techniques and diagnostics, operational aspects of mass release active experiments, the active observation of mass release experiments, active perturbation mass release experiments, simulating an artificial modification of the space environment, and active experiments to study fundamental plasma physics

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

DEFF Research Database (Denmark)

Christophersen, Philip C; Vaghela, Dimple; Müllertz, Anette

2014-01-01

The effect of food intake on the release and degradation of peptide drugs from solid lipid particles is unknown and was therefore investigated in vitro using different fed state media in a lipolysis model. Desmopressin was used as a model peptide and incorporated into solid lipid particles...... and the protease or desmopressin. Addition of a medium chain triglyceride, trilaurin, in combination with drug-loaded lipid particles diminished the food effect on the TG18 particles, and trilaurin is therefore proposed to be a suitable excipient for reduction of the food effect. Overall, the present study shows...... that strategies to reduce food effect, such as adding trilaurin, for lipid particle formulations should be considered as drug release from such formulations might be influenced by the presence of food in the gastrointestinal tract....

Release and nonvolatile operation of carbon nanotube nanorelay by resonant vibration

Energy Technology Data Exchange (ETDEWEB)

Kagota, Tatsuya; Takei, Kuniharu; Arie, Takayuki; Akita, Seiji, E-mail: akita@pe.osakafu-u.ac.jp [Department of Physics and Electronics, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531 (Japan); Nagataki, Atsuko [Department of Physics and Electronics, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531 (Japan); Materials Analysis Research Center, KRI, Inc., Osaka 554-0051 (Japan)

2013-11-11

We investigated the release of a stuck carbon nanotube (CNT) cantilever beam in nanorelay applications using a nano-manipulator. Even with strong adhesion induced by electrostatic attraction that is 100 times stronger than the van der Waals interaction, successful release of a nanotube arm from a stuck state was realized by the application of a resonant vibration to the stuck CNT arm. Furthermore, nonvolatile operation of the nanotube nanorelay was demonstrated by the application of the resonant vibration to the stuck CNT arm.

Stimulatory effects of neuronally released norepinephrine on renin release in vitro

Energy Technology Data Exchange (ETDEWEB)

Matsumura, Yasuo; Kawazoe, Shinka; Ichihara, Toshio; Shinyama, Hiroshi; Kageyama, Masaaki; Morimoto, Shiro (Osaka Univ. of Pharmaceutical Sciences (Japan))

1988-10-01

Extracellular high potassium inhibits renin release in vitro by increasing calcium concentrations in the juxtaglomerular cells. The authors found that the decreased response of renin release from rat kidney cortical slices in high potassium solution changed to a strikingly increased one in the presence of nifedipine at doses over 10{sup {minus}6} M. They then examined the stimulatory effect of extracellular high potassium in the presence of nifedipine on renin release. The enhancement of release was significantly suppressed either by propranolol or by metoprolol but not by prazosin. High potassium plus nifedipine-induced increase in renin release was markedly attenuated by renal denervation. The enhancing effect was not observed when the slices were incubated in calcium-free medium. Divalent cations such as Cd{sup 2+}, Co{sup 2+}, and Mn{sup 2+} blocked this enhancement in a concentration-dependent manner. High potassium elicited an increase in {sup 3}H efflux from the slices preloaded with ({sup 3}H)-norepinephrine. The increasing effect was not influenced by nifedipine but was abolished by the removal of extracellular calcium or by the addition of divalent cations. These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of {beta}-adrenoceptors.

Know the Facts: Understand Concussion

Centers for Disease Control (CDC) Podcasts

2010-03-17

This podcast discusses concussions and provides information to help people better understand concussion.  Created: 3/17/2010 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 3/17/2010.

Modelling isothermal fission gas release

International Nuclear Information System (INIS)

Uffelen, P. van

2002-01-01

The present paper presents a new fission gas release model consisting of two coupled modules. The first module treats the behaviour of the fission gas atoms in spherical grains with a distribution of grain sizes. This module considers single atom diffusion, trapping and fission induced re-solution of gas atoms associated with intragranular bubbles, and re-solution from the grain boundary into a few layers adjacent to the grain face. The second module considers the transport of the fission gas atoms along the grain boundaries. Four mechanisms are incorporated: diffusion controlled precipitation of gas atoms into bubbles, grain boundary bubble sweeping, re-solution of gas atoms into the adjacent grains and gas flow through open porosity when grain boundary bubbles are interconnected. The interconnection of the intergranular bubbles is affected both by the fraction of the grain face occupied by the cavities and by the balance between the bubble internal pressure and the hydrostatic pressure surrounding the bubbles. The model is under validation. In a first step, some numerical routines have been tested by means of analytic solutions. In a second step, the fission gas release model has been coupled with the FTEMP2 code of the Halden Reactor Project for the temperature distribution in the pellets. A parametric study of some steady-state irradiations and one power ramp have been simulated successfully. In particular, the Halden threshold for fission gas release and two simplified FUMEX cases have been computed and are summarised. (author)

A Look at the IEA 2011 Release of Strategic Oil Reserves

International Nuclear Information System (INIS)

Glick, Devin

2011-07-01

On June 23, 2011, the International Energy Agency (IEA) coordinated the release of 60 million barrels of emergency stocks in response to the disruption of oil production in Libya due to civil unrest. This announcement elicited a mixed reaction from the public and from the market. Some politicians in the United States called the move a political decision by the President to satisfy voters, private oil companies did not like the interference, and some OPEC countries were upset and called the release unnecessary. The reason why there was a strong reaction was because the IEA had never coordinated a release in this manner before. It was only the third time there had ever been a release, after the First Gulf War in 1991 and for Hurricane Katrina and Rita in 2005. The circumstance and decision for the June 23 drawdown was more flexible and may signal a change in the way strategic petroleum stocks are used. This paper examines the motivations and the potential consequences of the International Energy Agency's coordinated action to release petroleum stocks on June 23, 2011. (author)

Long term safety assessment of geological waste disposal systems: issues on release scenarios

International Nuclear Information System (INIS)

Khan, S.A.; Qureshi, A.A.

1995-01-01

Geological insolation of high level nuclear waste is an attractive waste disposal concept. However, long term safety demonstration of this concept is a major challenge to the operators, regulators and the scientific community. Identification of the factors responsible for the release of radionuclides from geosphere to biosphere,is first step in this regard. Current understanding of the release scenarios indicates that faulting, ground after percolation, seismicity, volcanism and human intrusion are the dominating release factors for most of the candidate rock formations. The major source of uncertainties is the probability values of various release events due to random nature of catastrophic geological events and past poor historical records of the frequencies of such events. There is consensus among the experts that the waste release via human intrusion is the most unpredictable scenario at present state of the knowledge. (author)

Digital Learning in California's K-12 Schools. Just the Facts

Science.gov (United States)

Gao, Niu

2015-01-01

This fact page briefly discusses the following facts on digital learning in California's K-12: (1) As California implements new tests in its K-12 schools, technology infrastructure is a key concern; (2) Many districts are confident that they had enough bandwidth for online field tests; (3) Digital learning will require significantly greater…

Institutional Facts and the NaturalisticFallacy : Confronting Searle with Searle

NARCIS (Netherlands)

Hindriks, Frank

2002-01-01

In 1964 Searle argued against the naturalistic fallacy thesis that an ought-statement can in fact be derived from is-statements. From an analysis of this argument and of Searle’s social ontology of 1995 – which includes a full-blown theory of institutional facts – I conclude that this argument is

Effect of power change on fission gas release. Re-irradiation tests of spent fuel at JMTR

International Nuclear Information System (INIS)

Nakamura, Jinichi; Shimizu, Michio; Ishii, Tadahiko; Endo, Yasuichi; Ohwada, Isao; Nabeya, Hideaki; Uetsuka, Hiroshi

1999-01-01

A full length rod irradiated at Tsuruga unit 1 was refabricated to short length rods, and rod inner pressure gauges were re-instrumented to the rods. Re-irradiation tests to study the fission gas release during power change were carried out by means of BOCA/OSF-1 facility at the JMTR. In the tests, steady state operation at 40 kW/m and power cycling operations between 20 and 40 kW/m were conducted for the same high power holding time, and the rod inner pressure change during the tests was measured. The rod inner pressure increase was observed during power change, especially during power reduction. The rod inner pressure increase during a power cycling depended on the length of the high power operation just before the power cycling. The fission gas release during power reduction is estimated to be the release from fission gas bubbles on the grain boundary caused by the thermal stress in the pellet during power reduction. When steady state operation and power cycling were repeated at the power levels of 30, 35 and 40 kW/m, the power cycling accelerated the fission gas release compared with the steady state operation. (author)

Extended‐Release Once‐Daily Formulation of Tofacitinib: Evaluation of Pharmacokinetics Compared With Immediate‐Release Tofacitinib and Impact of Food

Science.gov (United States)

Wang, Rong; Fletcher, Tracey; Alvey, Christine; Kushner, Joseph; Stock, Thomas C.

2016-01-01

Abstract Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. An extended‐release (XR) formulation has been designed to provide a once‐daily (QD) dosing option to patients to achieve comparable pharmacokinetic (PK) parameters to the twice‐daily immediate‐release (IR) formulation. We conducted 2 randomized, open‐label, phase 1 studies in healthy volunteers. Study A characterized single‐dose and steady‐state PK of tofacitinib XR 11 mg QD and intended to demonstrate equivalence of exposure under single‐dose and steady‐state conditions to tofacitinib IR 5 mg twice daily. Study B assessed the effect of a high‐fat meal on the bioavailability of tofacitinib from the XR formulation. Safety and tolerability were monitored in both studies. In study A (N = 24), the XR and IR formulations achieved time to maximum plasma concentration at 4 hours and 0.5 hours postdose, respectively; terminal half‐life was 5.9 hours and 3.2 hours, respectively. Area under plasma concentration‐time curve (AUC) and maximum plasma concentration (Cmax) after single‐ and multiple‐dose administration were equivalent between the XR and IR formulations. In study B (N = 24), no difference in AUC was observed for fed vs fasted conditions. Cmax increased by 27% under the fed state. On repeat administration, negligible accumulation (Tofacitinib administration as an XR or IR formulation was generally well tolerated in these studies. PMID:26970526

Advancing Concentrating Solar Power Research (Fact Sheet)

Energy Technology Data Exchange (ETDEWEB)

None, None

2014-02-01

Researchers at the National Renewable Energy Laboratory (NREL) provide scientific, engineering, and analytical expertise to help advance innovation in concentrating solar power (CSP). This fact sheet summarizes how NREL is advancing CSP research.

Mastering Fact Fluency: Are They Game?

Science.gov (United States)

Godfrey, Connie J.; Stone, Jamalee

2013-01-01

Math games can be powerful tools in helping students achieve automaticity in basic addition and related subtraction facts if both teachers and students use them purposefully. According to the National Council of Teachers of Mathematics (NCTM 2000), developing a solid mathematical foundation is essential for every child in prekindergarten through…

The Manager's Job: Folklore and Fact

Science.gov (United States)

Mintzberg, Henry

1975-01-01

Contrasts popular myths about managers' duties with the facts, as indicated by various studies of managers and how they function. The author argues that managers often have distorted views of their role, and that they must first recognize what their job really involves in order to perform it effectively. (JG)

Fission gas release during power change by means of re-irradiation of spent fuel