Sample records for release rate time

  1. Optimum timing for integrated pest management: modelling rates of pesticide application and natural enemy releases.

    Tang, Sanyi; Tang, Guangyao; Cheke, Robert A


    Many factors including pest natural enemy ratios, starting densities, timings of natural enemy releases, dosages and timings of insecticide applications and instantaneous killing rates of pesticides on both pests and natural enemies can affect the success of IPM control programmes. To address how such factors influence successful pest control, hybrid impulsive pest-natural enemy models with different frequencies of pesticide sprays and natural enemy releases were proposed and analyzed. With releasing both more or less frequent than the sprays, a stability threshold condition for a pest eradication periodic solution is provided. Moreover, the effects of times of spraying pesticides (or releasing natural enemies) and control tactics on the threshold condition were investigated with regard to the extent of depression or resurgence resulting from pulses of pesticide applications. Multiple attractors from which the pest population oscillates with different amplitudes can coexist for a wide range of parameters and the switch-like transitions among these attractors showed that varying dosages and frequencies of insecticide applications and the numbers of natural enemies released are crucial. To see how the pesticide applications could be reduced, we developed a model involving periodic releases of natural enemies with chemical control applied only when the densities of the pest reached the given Economic Threshold. The results indicate that the pest outbreak period or frequency largely depends on the initial densities and the control tactics.

  2. Effects of Time-Release Caffeine Containing Supplement on Metabolic Rate, Glycerol Concentration and Performance

    Adam M. Gonzalez, Jay R. Hoffman, Adam J. Wells, Gerald T. Mangine, Jeremy R. Townsend, Adam R. Jajtner, Ran Wang, Amelia A. Miramonti, Gabriel J. Pruna, Michael B. LaMonica, Jonathan D. Bohner, Mattan W. Hoffman, Leonardo P. Oliveira, David H. Fukuda, Maren S. Fragala, Jeffrey R. Stout


    Full Text Available This study compared caffeine pharmacokinetics, glycerol concentrations, metabolic rate, and performance measures following ingestion of a time-release caffeine containing supplement (TR-CAF versus a regular caffeine capsule (CAF and a placebo (PL. Following a double-blind, placebo-controlled, randomized, cross-over design, ten males (25.9 ± 3.2 y who regularly consume caffeine ingested capsules containing either TR-CAF, CAF, or PL. Blood draws and performance measures occurred at every hour over an 8-hour period. Plasma caffeine concentrations were significantly greater (p < 0.05 in CAF compared to TR-CAF during hours 2-5 and significantly greater (p = 0.042 in TR-CAF compared to CAF at hour 8. There were no significant differences between trials in glycerol concentrations (p = 0.86 or metabolic measures (p = 0.17-0.91. Physical reaction time was significantly improved for CAF at hour 5 (p=0.01 compared to PL. Average upper body reaction time was significantly improved for CAF and TR-CAF during hours 1-4 (p = 0.04 and p = 0.01, respectively and over the 8-hour period (p = 0.04 and p = 0.001, respectively compared to PL. Average upper body reaction time was also significantly improved for TR-CAF compared to PL during hours 5-8 (p = 0.004. TR-CAF and CAF showed distinct pharmacokinetics yielding modest effects on reaction time, yet did not alter glycerol concentration, metabolic measures, or other performance measures.

  3. Inverse identification of the release location, temporal rates, and sensor alarming time of an airborne pollutant source.

    Zhang, T; Zhou, H; Wang, S


    With an accidental release of an airborne pollutant, it is always critical to know where, when, and how the pollutant has been released. Then, emergency measures can be scientifically advised to prevent any possible harm. This investigation proposes an inverse model to identify the release location, the temporal rate profile, and the sensor alarming time from the start of a pollutant release. The first step is to implement the inverse operation to the cause-effect matrix to obtain the release rate profiles for discrete candidate scenarios with concentration information provided by one sensor. The second step is to interpret the occurrence probability of each solution in the first step with the Bayesian model by matching the concentration at the other sensor. The proposed model was applied to identify a single pollutant source in a two-dimensional enclosure using measurement data and in a three-dimensional aircraft cabin with simulated data. The results show that the model is able to correctly determine the pollutant source location, the temporal rate profile, and the sensor alarming time. The known conditions for input into the inverse model include a steady flow field and the valid temporal concentrations at two different locations. The proposed inverse model can tell where, when, and how a gaseous pollutant has been accidently released based on the monitoring concentrations measured by two sensors. This methodology can be useful for providing emergency protection to indoor occupants. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

    Jeong, Jae Kwan; Choi, In Soo; Kang, Hyun Gu; Hur, Tai Young


    This study investigated the effects of gonadotrophin-releasing hormone (GnRH) administration (Experiment 1) and a controlled internal drug-releasing (CIDR) insert (Experiment 2) after timed artificial insemination (TAI) on the pregnancy rates of dairy cows. In Experiment 1, 569 dairy cows that underwent TAI (day 0) following short-term synchronization with prostaglandin F2α were randomly allocated into two groups: no further treatment (control, n = 307) or injection of 100 µg of gonadorelin on day 5 (GnRH, n = 262). In Experiment 2, 279 dairy cows that underwent TAI (day 0) following Ovsynch were randomly allocated into two groups: no further treatment (control, n = 140) or CIDR insert treatment from days 3.5 to 18 (CIDR, n = 139). The probability of pregnancy following TAI did not differ between the GnRH (34.4%) and control (31.6%, p > 0.05) groups. However, the probability of pregnancy following TAI was higher (odds ratio: 1.74, p < 0.05) in the CIDR group (51.1%) than in the control group (39.3%). Overall, CIDR insert treatment at days 3.5 to 18 increased pregnancy rates relative to non-treated controls, whereas a single GnRH administration on day 5 did not affect the pregnancy outcomes of dairy cows. PMID:27030200

  5. Ovarian responses and pregnancy rate with previously used intravaginal progesterone releasing devices for fixed-time artificial insemination in sheep.

    Vilariño, M; Rubianes, E; Menchaca, A


    The objective was to determine serum progesterone concentrations, ovarian responses, and pregnancy rate in sheep inseminated following a short-term protocol (6 days of treatment) with a previously used controlled internal drug release-G (CIDR-G) device. In experiment 1, 30 ewes were put on a short-term protocol using a CIDR-G of first use (new devices, N = 10), second use (previously used for 6 days, N = 10), or third use (previously used twice for 6 days, N = 10). All ewes were given prostaglandin F(2α) (10 mg dinoprost) and eCG (300 IU) im at device withdrawal. Mean serum progesterone concentrations were greater for ewes treated with new versus reused devices (P synchronization and ovulation, with lower serum progesterone concentrations for reused devices. Three times used CIDR-G yielded a pregnancy rate >70%, which tended to be lower than that obtained with new devices, adding evidence of the detrimental effect of low serum progesterone concentrations on fertility in sheep.

  6. Pregnancy rates to timed artificial insemination in dairy cows treated with gonadotropin-releasing hormone or porcine luteinizing hormone.

    Colazo, M G; Gordon, M B; Rajamahendran, R; Mapletoft, R J; Ambrose, D J


    We compared the effects of porcine luteinizing hormone (pLH) versus gonadotropin-releasing hormone (GnRH) on ovulatory response and pregnancy rate after timed artificial insemination (TAI) in 605 lactating dairy cows. Cows (mean+/-SEM: 2.4+/-0.08 lactations, 109.0+/-2.5 d in milk, and 2.8+/-0.02 body condition score) at three locations were assigned to receive, in a 2x2 factorial design, either 100 microg GnRH or 25mg pLH im on Day 0, 500 microg cloprostenol (PGF) on Day 7, and GnRH or pLH on Day 9, with TAI 14 to 18h later. Ultrasonographic examinations were performed in a subset of cows on Days 0, 7, 10, and 11 to determine ovulations, presence of corpus luteum, and follicle diameter and in all cows 32 d after TAI for pregnancy determination. In 35 cows, plasma progesterone concentrations were determined 0, 3, 4, 5, 6, 7, and 12 d after ovulation. The proportion of noncyclic cows and cows with ovarian cysts on Day 0 were 12% and 6%, respectively. Ovulatory response to first treatment was 62% versus 44% for pLH and GnRH and 78% versus 50% for noncyclic and cyclic cows (PpLH or GnRH, cyclic status, presence of an ovarian cyst, and preovulatory follicle size did not affect pregnancy rate. Plasma progesterone concentrations after TAI did not differ among treatments. Pregnancy rate to TAI was greater (PpLH group (42%) than in the other three groups (28%, 30%, and 26% for GnRH/PGF/GnRH, pLH/PGF/GnRH, and pLH/PGF/pLH, respectively). Although only 3% of cows given pLH in lieu of GnRH on Day 9 lost their embryo versus 7% in those subjected to a conventional TAI using two GnRH treatments, the difference was not statistically significant. In summary, pLH treatment on Day 0 increased ovulatory response but not pregnancy rate. Cows treated with GnRH/PGF/pLH had the highest pregnancy rate to TAI, but progesterone concentrations after TAI were not increased. In addition, preovulatory follicle diameter did not affect pregnancy rate.

  7. Effects of heat release rate on NOx time history in diesel combustion; Diesel nensho ni okeru netsu hasseiritsu keika ga NOx nodo rireki ni oyobosu eikyo

    Ishiyama, T.; Miwa, K.; Higashida, M. [Tokushima Univ., Tokushima (Japan). Faculty of Engineering; Watanabe, S. [Kawasaki Heavy Industries, Ltd., Kobe (Japan)


    For determining the optimum combination of combustion control techniques to reduce NOx emission from diesel engines, it is important to clarify the effects of each technique not only on the NOx emission but also on its time history during combustion. In this paper, NOx concentration in the combustion chamber of a rapid compression machine has been measured by using a total gas sampling method. In order to elucidate the relation between NOx history and heat release rate, air temperatures nozzle hole size and air motion are varied to control the heat release process. The results show that NOx emission is not solely dependent upon initial combustion. Air utilization in the main diffusive combustion phase has great influence on NOx formation and its decay. NOx formation is accelerated by activation of the initial stage of the main combustion when using a nozzle with small holes. 9 refs., 13 figs.

  8. Comparison of pregnancy rates in beef cattle after a fixed-time AI with once- or twice-used controlled internal drug release devices.

    Muth-Spurlock, A M; Poole, D H; Whisnant, C S


    The use of fixed-time artificial insemination (FTAI) provides producers with numerous benefits including the use of superior genetics, shorter breeding and calving seasons, and a more uniform calf crop. However, the cost of implementing FTAI protocols is one of the several drawbacks hindering their use in the beef industry. Potential injection-site lesions from intramuscular injections of the hormones necessary for estrus synchronization are also a cause of concern for carcass quality. The objectives of this experiment were to (1) determine whether or not a twice-used controlled internal drug release (CIDR) device would be effective in an FTAI protocol without adversely affecting pregnancy rate and (2) whether or not the subcutaneous administration of PGF2α affects pregnancy rate. Nulliparous females (n = 99) between 13 and 27 months of age and multiparous cows (n = 43) between 48 and 74 months of age were synchronized for estrus using the 7-day CO-Synch + CIDR protocol. The females were randomly assigned to one of the two treatments: (1) a once-used CIDR (control) or (2) a twice-used CIDR device (treatment) incorporated into their synchronization protocol. The females were also randomly assigned to have their injection of PGF2α administered either intramuscularly or subcutaneously. Blood was taken in a random subset of nulliparous females (n = 52) just before device removal and assayed for concentration of progesterone. The concentration of progesterone was higher (P = 0.01) in the animals that received once-used CIDR devices than that in those received twice-used CIDR devices (3.4 ± 0.5 and 1.4 ± 0.5 ng/mL, respectively). There was no significant effect of parity (P = 0.82), artificial insemination technician (P = 0.60), PGF2α administration (P = 0.83), or treatment (P = 0.67) on pregnancy rates to artificial insemination which were 75.4 ± 6.0% and 71.7 ± 6.4%, for animals that received once- and twice-used CIDR devices, respectively. This study provides

  9. 49 CFR 236.790 - Release, time.


    ... 49 Transportation 4 2010-10-01 2010-10-01 false Release, time. 236.790 Section 236.790... Release, time. A device used to prevent the operation of an operative unit until after the expiration of a predetermined time interval after the device has been actuated....


    Zamecnik, J; Michael Bronikowski, M; Alex Cozzi, A; Russell Eibling, R; Charles Nash, C


    The Modular Caustic-Side Solvent Extraction (CSSX) Unit (MCU) and the Salt Waste Processing Facility (SWPF) will produce a Decontaminated Salt Solution (DSS) that will go to the Saltstone Production Facility (SPF). Recent information indicates that solvent entrainment in the DSS is larger than expected. The main concern is with Isopar{reg_sign} L, the diluent in the solvent mixture, and its flammability in the saltstone vault. If it is assumed that all the Isopar{reg_sign} L is released instantaneously into the vault from the curing grout before each subsequent pour, the Isopar{reg_sign} L in the vault headspace is well mixed, and each pour displaces an equivalent volume of headspace, the maximum concentration of Isopar{reg_sign} L in the DSS to assure 25% of the lower flammable limit is not exceeded has been determined to be about 4 ppm. The amount allowed would be higher if the release from grout were significantly less. The Savannah River National Laboratory was tasked with determining the release of Isopar{reg_sign} L from saltstone prepared with a simulated DSS with Isopar{reg_sign} L concentrations ranging from 50 to 200 mg/L in the salt fraction and with test temperatures ranging from ambient to 95 C. The results from the curing of the saltstone showed that the amount of Isopar{reg_sign} L released versus time can be treated as a percentage of initial amount present; there was no statistically significant dependence of the release rate on the initial concentration. The majority of the Isopar{reg_sign} L that was released over the test duration was released in the first few days. The release of Isopar{reg_sign} L begins immediately and the rate of release decreases over time. At higher temperatures the immediate release rate is larger than at lower temperatures. Initial curing temperature was found to be very important as slight variations during the first few hours or days had a significant effect on the amount of Isopar{reg_sign} L released. Short scoping

  11. No Superiority of Treatment With Osmotic Controlled-Release Oral Delivery System-Methylphenidate Over Short/Medium-Acting Methylphenidate Preparations in the Rate and Timing of Injuries in Children With Attention-Deficit/Hyperactivity Disorder.

    Golubchik, Pavel; Kodesh, Arad; Weizman, Abraham

    Methylphenidate (MPH) treatment in patients with attention-deficit/hyperactivity disorder (ADHD) is reported to reduce the risk for injuries. In the present study, the rate and timing of injuries were compared among the various MPH preparations (4 and 6-8 vs 12 hour-acting) in children with ADHD. This real-world retrospective study covered the years 2011 to 2013. Participants included 2042 youngsters (aged 4-18 years, 13.01 ± 3.2 years; 71.8% males and 28.2% females) diagnosed with ADHD according to the International Statistical Classification of Diseases, 10th Revision criteria and treated with various MPH preparations. They were divided into 2 groups by their treatment preparation as follows: MPH-immediate release (MPH-IR)-4 hour-acting pooled with MPH-slow release/long-acting (MPH-SR/LA)- 6 to 8 hour-acting versus osmotic controlled-release oral delivery system-MPH (OROS-MPH; Concerta)-12 hour-acting that consisted of pooling of OROS-MPH only and OROS-MPH combined with the other MPH preparations. The monthly rates of injury, specifically, late injury (occurrence between 4:00 p.m. to midnight) and for multiple injuries, the time interval between injuries, were assessed. No significant differences in monthly rate of nonfatal injuries were found between OROS-MPH with or without 4/6 to 8 hour-acting MPH-formulations versus only 4/6 to 8 hour-acting MPH-preparations (P = 0.53). Neither were differences found in the between-injury time interval (P = 0.83) or in late-injury-rates (P = 0.37) between those groups. This real-world-naturalistic study in the community demonstrates that, in ADHD pediatric populations, OROS-MPH preparation is not superior to short/medium-acting (4/6-8 hours) MPH preparations regarding the rate and timing of injuries.

  12. ISOPAR L Release Rates from Saltstone Using Simulated Salt Solutions

    Bronikowski, M


    The Modular Caustic-Side Solvent Extraction (CSSX) Unit (MCU) and the Salt Waste Processing Facility (SWPF) will produce a Deactivated Salt Solution (DSS) that will go to the Saltstone Production Facility (SPF). Recent information indicates that solvent entrainment in the DSS is larger than expected. The main concern is with Isopar{reg_sign} L, the diluent in the solvent mixture, and its flammability in the saltstone vault. If it is assumed that all the Isopar{reg_sign} L is released instantaneously into the vault from the curing grout before each subsequent pour; the Isopar{reg_sign} L in the vault headspace is well mixed; and each pour displaces an equivalent volume of headspace, the allowable concentration of Isopar{reg_sign} L in the DSS sent to SPF has been calculated at approximately 4 ppm. The amount allowed would be higher, if the release from grout were significantly less. The Savannah River National Laboratory was tasked with determining the release of Isopar{reg_sign} L from saltstone prepared with a simulated DSS with Isopar{reg_sign} L concentrations ranging from 50 mg/L to 200 mg/L in the salt fraction and with test temperatures ranging from ambient to 95 C. The results from the curing of the saltstone showed that the Isopar{reg_sign} L release data can be treated as a percentage of initial concentration in the concentration range studied. The majority of the Isopar{reg_sign} L that was released over the test duration was released in the first few days. The release of Isopar{reg_sign} L begins immediately and the rate of release decreases over time. At higher temperatures the immediate release is larger than at lower temperatures. In one test at 95 C essentially all of the Isopar{reg_sign} L was released in three months. Initial curing temperature was found to be very important as slight variations during the first few days affected the final Isopar{reg_sign} L amount released. Short scoping tests at 95 C with solvent containing all components (Isopar

  13. Patient release criteria for low dose rate brachytherapy implants.

    Boyce, Dale E; Sheetz, Michael A


    A lack of consensus regarding a model governing the release of patients following sealed source brachytherapy has led to a set of patient release policies that vary from institution to institution. The U.S. Nuclear Regulatory Commission has issued regulatory guidance on patient release in NUREG 1556, Volume 9, Rev. 2, Appendix U, which allows calculation of release limits following implant brachytherapy. While the formalism presented in NUREG is meaningful for the calculation of release limits in the context of relatively high energy gamma emitters, it does not estimate accurately the effective dose equivalent for the common low dose rate brachytherapy sources Cs, I, and Pd. NUREG 1556 states that patient release may be based on patient-specific calculations as long as the calculation is documented. This work is intended to provide a format for patient-specific calculations to be used for the consideration of patients' release following the implantation of certain low dose rate brachytherapy isotopes.

  14. Timing crisis information release via television.

    Wei, Jiuchang; Zhao, Dingtao; Yang, Feng; Du, Shaofu; Marinova, Dora


    When and how often to release information on television are important issues in crisis and emergency risk communication. There is a lot of crisis information, including warnings and news, to which people should have access, but most of it is not significantly urgent to interrupt the broadcasting of television programmes. Hence, the right timing for the release of crisis information should be selected based on the importance of the crisis and any associated communication requirements. Using recursive methods, this paper builds an audience coverage model of crisis information release. Based on 2007 Household Using TV (HUT) data for Hefei City, China, the optimal combination of broadcasting sequence (with frequencies between one and eight times) is obtained using the implicit enumeration method. The developed model is applicable to effective transmission of crisis information, with the aim of reducing interference with the normal television transmission process and decreasing the psychological effect on audiences. The same model can be employed for other purposes, such as news coverage and weather and road information.

  15. Determining drug release rates of hydrophobic compounds from nanocarriers.

    D'Addio, Suzanne M; Bukari, Abdallah A; Dawoud, Mohammed; Bunjes, Heike; Rinaldi, Carlos; Prud'homme, Robert K


    Obtaining meaningful drug release profiles for drug formulations is essential prior to in vivo testing and for ensuring consistent quality. The release kinetics of hydrophobic drugs from nanocarriers (NCs) are not well understood because the standard protocols for maintaining sink conditions and sampling are not valid owing to mass transfer and solubility limitations. In this work, a new in vitroassay protocol based on 'lipid sinks' and magnetic separation produces release conditions that mimic the concentrations of lipid membranes and lipoproteins in vivo, facilitates separation, and thus allows determination of intrinsic release rates of drugs from NCs. The assay protocol is validated by (i) determining the magnetic separation efficiency, (ii) demonstrating that sink condition requirements are met, and (iii) accounting for drug by completing a mass balance. NCs of itraconazole and cyclosporine A (CsA) were prepared and the drug release profiles were determined. This release protocol has been used to compare the drug release from a polymer stabilized NC of CsA to a solid drug NP of CsA alone. These data have led to the finding that stabilizing block copolymer layers have a retarding effect on drug release from NCs, reducing the rate of CsA release fourfold compared with the nanoparticle without a polymer coating.This article is part of the themed issue 'Soft interfacial materials: from fundamentals to formulation'.

  16. Release-rate calorimetry of multilayered materials for aircraft seats

    Fewell, L. L.; Parker, J. A.; Duskin, F.; Speith, H.; Trabold, E.


    Multilayered samples of contemporary and improved fire-resistant aircraft seat materials were evaluated for their rates of heat release and smoke generation. Top layers with glass-fiber block cushion were evaluated to determine which materials, based on their minimum contributions to the total heat release of the multilayered assembly, may be added or deleted. The smoke and heat release rates of multilayered seat materials were then measured at heat fluxes of 1.5 and 3.5 W/cm2. Abrasion tests were conducted on the decorative fabric covering and slip sheet to ascertain service life and compatibility of layers

  17. Disestablishing Sex: The Case for Released-Time Sex Education

    Glanzer, Perry L.


    Allowing nonschool organizations to provide sex education in a released-time format would disestablish state-funded sex education and give families a choice in the sex education that would be provided for their children. Released-time programs, as originally conceived and currently practiced, allow students to be released for a period of time…

  18. Disestablishing Sex: The Case for Released-Time Sex Education

    Glanzer, Perry L.


    Allowing nonschool organizations to provide sex education in a released-time format would disestablish state-funded sex education and give families a choice in the sex education that would be provided for their children. Released-time programs, as originally conceived and currently practiced, allow students to be released for a period of time…

  19. 77 FR 47918 - Information Collection Activities (Released Rates)


    ... Surface Transportation Board Information Collection Activities (Released Rates) AGENCY: Surface... notice of its intent to seek from the Office of Management and Budget (OMB) approval of the information... required movers to provide certain information concerning the two available cargo-liability options on...

  20. Anthropogenic carbon release rate unprecedented during past 66 million years

    Zeebe, R. E.; Ridgwell, A.; Zachos, J. C.


    Carbon release rates from anthropogenic sources have reached a record high of about 10 Pg C/y in 2013. However, due to uncertainties in the strength of climate system feedbacks, the full impact of the rapid carbon release on the Earth system is difficult to predict with confidence. Geologic analogues from past transient climate changes could provide invaluable constraints but only if the associated carbon release rates can be reliably reconstructed. We present a new technique - based on combined data-model analysis - to extract rates of change from the geological record, without the need for a stratigraphic age model. Given currently available records, we then show that the present anthropogenic carbon release rate is unprecedented during the Cenozoic (past 66 million years) by at least an order of magnitude. Our results have important implications for our ability to use past analogues to predict future changes, including constraints on climate sensitivity, ocean acidification, and impacts on marine and terrestrial ecosystems. For example, the fact that we have effectively entered an era of 'no analogue' state presents fundamental challenges to constraining forward modeling. Furthermore, future ecosystem disruptions will likely exceed the relatively limited extinctions observed during climate aberrations throughout the Cenozoic.

  1. Effects of flow and water chemistry on lead release rates from pipe scales.

    Xie, Yanjiao; Giammar, Daniel E


    Lead release from pipe scales was investigated under different water compositions, stagnation times, and flow regimes. Pipe scales containing PbO(2) and hydrocerussite (Pb(3)(OH)(2)(CO(3))(2)) were developed on lead pipes by conditioning the pipes with water containing free chlorine for eight months. Water chemistry and the composition of the pipe scales are two key factors affecting lead release from pipe scales. The water rarely reached equilibrium with pipe scales within one day, which makes solid-water contact time and corrosion product dissolution rates the controlling factors of lead concentrations for the conditions tested. Among five water compositions studied, a solution with orthophosphate had the lowest dissolved lead release rate and highest particulate lead release rate. Free chlorine also decreased the dissolved lead release rate at stagnant conditions. Water flow increased rates of release of both dissolved and particulate lead by accelerating the mass transfer of lead out of the porous pipe scales and by physically destabilizing pipe scales. Dissolved lead comprised the majority of the lead released at both stagnant and laminar flow conditions. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Simultaneous drug release at different rates from biodegradable polyurethane foams.

    Sivak, Wesley N; Zhang, Jianying; Petoud, Stephané; Beckman, Eric J


    In this study, we present an approach for the simultaneous release of multiple drug compounds at different rates from single-phase polyurethane foams constructed from lysine diisocyanate (LDI) and glycerol. The anti-cancer compounds DB-67 and doxorubicin were covalently incorporated into polyurethane foams, whereby drug release can then occur in concert with material degradation. To begin, the reactions of DB-67 and doxorubicin with LDI in the presence of a tertiary amine catalyst were monitored with infrared spectroscopy; each compound formed urethane linkages with LDI. Fluorescent spectra of DB-67 and doxorubicin were then recorded in phosphate-buffered saline, pH 7.4 (PBS), to ensure that each anti-cancer compound could be quantitatively detected alone and in combination. Doxorubicin and DB-67 were then incorporated into a series of degradable LDI-glycerol polyurethane foams alone and in combination with one another. The sol content, average porosity and drug distribution throughout each foam sample was measured and found to be similar amongst all foam samples. The stability of DB-67 and doxorubicin's fluorescent signal was then assessed over a 2-week period at 70 degrees C. Release rates of the compounds from the foams were assessed over a 10-week period at 4, 22, 37 and 70 degrees C by way of fluorescence spectroscopy. Release was found to be temperature-dependent, with rates related to the chemical structure of the incorporated drug. This study demonstrates that differential release of covalently bound drugs is possible from simple single-phase, degradable polyurethane foams.

  3. Real-time imaging of renin release in vitro.

    Peti-Peterdi, János; Fintha, Attila; Fuson, Amanda L; Tousson, Albert; Chow, Robert H


    Renin release from juxtaglomerular granular cells is considered the rate-limiting step in activation of the renin-angiotensin system that helps to maintain body salt and water balance. Available assays to measure renin release are complex, indirect, and work with significant internal errors. To directly visualize and study the dynamics of both the release and tissue activity of renin, we isolated and perfused afferent arterioles with attached glomeruli dissected from rabbit kidneys and used multiphoton fluorescence imaging. Acidotropic fluorophores, such as quinacrine and LysoTrackers, clearly and selectively labeled renin granules. Immunohistochemistry of mouse kidney with a specific renin antibody and quinacrine staining colocalized renin granules and quinacrine fluorescence. A low-salt diet for 1 wk caused an approximately fivefold increase in the number of both individual granules and renin-positive granular cells. Time-lapse imaging showed no signs of granule trafficking or any movement, only the dimming and disappearance of fluorescence from individual renin granules within 1 s in response to 100 microM isoproterenol. There appeared to be a quantal release of the granular contents; i.e., an all-or-none phenomenon. Using As4.1 cells, a granular cell line, we observed further classic signs of granule exocytosis, the emptying of granule content associated with a flash of quinacrine fluorescence. Using a fluorescence resonance energy transfer-based, 5-(2-aminoethylamino)naphthalene-1-sulfonic acid (EDANS)-conjugated renin substrate in the bath, an increase in EDANS fluorescence (renin activity) was observed around granular cells in response to isoproterenol. Fluorescence microscopy is an excellent tool for the further study of the mechanism, regulation, and dynamics of renin release.

  4. Comodulation masking release in bit-rate reduction systems

    Vestergaard, Martin D.; Rasmussen, Karsten Bo; Poulsen, Torben


    It has been suggested that the level dependence of the upper masking slopebe utilised in perceptual models in bit-rate reduction systems. However,comodulation masking release (CMR) phenomena lead to a reduction of themasking effect when a masker and a probe signal are amplitude modulated withthe...... same frequency. In bit-rate reduction systems the masker would be theaudio signal and the probe signal would represent the quantization noise.Masking curves have been determined for sinusoids and 1-Bark-wide noisemaskers in order to investigate the risk of CMR, when quantizing depths arefixed...

  5. Parallel Machine Problems with a Single Server and Release Times

    SHI Ling


    Parallel machine problems with a single server and release times are generalizations of classical parallel machine problems.Before processing, each job must be loaded on a machine, which takes a certain release times and a certain setup times.All these setups have to be done by a single server, which can handle at most one job at a time.In this paper, we continue studying the complexity result for parallel machine problem with a single and release times.New complexity results are derived for special cases.

  6. Pregnancy rates after fixed-time artificial insemination of Brahman heifers treated to synchronize ovulation with low-dose intravaginal progesterone releasing devices, with or without eCG.

    Butler, S A A; Atkinson, P C; Boe-Hansen, G B; Burns, B M; Dawson, K; Bo, G A; McGowan, M R


    The objective was to determine whether eCG in an ovulation synchronization protocol with an intravaginal progesterone (P(4))-releasing device (IPRD) containing a low dose of P(4) improves pregnancy rate (PR) to fixed-time AI (FTAI) in Bos indicus heifers. Day 0, 2 y old Brahman heifers were allocated to either eCG+ (n = 159) or eCG- (n = 157) treatment groups. All heifers were weighed, body condition scored (BCS), and ultrasonographically examined to measure uterine horn diameter and presence of a CL. On Day 0, all heifers received a low-dose IPRD (0.78 g P(4)) and 1 mg of estradiol benzoate (EB) im. On Day 8, the IPRD was removed, all heifers received 500 μg cloprostenol im, and those in the eCG+ treatment group received 300 IU of eCG im. On Day 9, all heifers received 1 mg EB im. All heifers were FTAI 52 to 56 h after IPRD removal. Ten days after FTAI, heifers were exposed to bulls. Heifers were diagnosed as pregnant to FTAI, natural mating, or not detectably pregnant (NDP) 65 d after FTAI. Treatment with eCG+ as compared to eCG- did not affect PR to FTAI (28.9 vs 30.6%; P = 0.590), natural mating (51.3 vs 47.7%; P = 0.595), or overall (65.4 vs 63.7%; P = 0.872). Mean live weight gain from Days 0 to 65 d post-FTAI was higher in heifers pregnant to FTAI (72.29 ± 4.26 kg; P = 0.033) and overall (66.83 ± 3.65 kg; P = 0.021), compared to heifers that were NDP (60.03 ± 3.16 kg). Uterine diameter group, 9-11, 12-13, and 14-20 mm (26.2, 31.3, and 33.3%; P = 0.256), presence and absence of CL (29.8 vs 29.4%; P = 0.975), AI technicians 1, 2, and 3 (32.6, 28.8, and 22.4%; P = 0.293) and sires A, B, and C (23.9, 36.0 and 27.0%; P = 0.122) had no effect on PR to FTAI, natural mating, or overall. In conclusion, treatment of primarily cycling Brahman heifers with 300 IU eCG in conjunction with a low P(4)-dose (0.78 g) IPRD and EB to synchronize ovulation, did not improve PR after FTAI, natural mating, or overall. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Comodulation masking release in bit-rate reduction systems

    Vestergaard, Martin David; Rasmussen, Karsten Bo; Poulsen, Torben


    It has been suggested that the level dependence of the upper masking slope be utilized in perceptual models in bit-rate reduction systems. However, comodulation masking release (CMR) phenomena lead to a reduction of the masking effect when a masker and a probe signal are amplitude modulated...... with the same frequency. In bit-rate reduction systems the masker would be the audio signal and the probe signal would represent the quantization noise. Masking curves have been determined for sinusoids and 1-Bark-wide noise maskers in order to investigate the risk of CMR, when quantizing depths are fixed.......75. A CMR of up to 10 dB was obtained at a distance of 6 Bark above the masker. The amount of CMR was found to depend on the presentation level of the masker; a higher masker level leads to a higher CMR effect. Hence, the risk of CMR affecting the subjective performance of bit-rate reduction systems cannot...

  8. Inverse modelling of radionuclide release rates using gamma dose rate observations

    Hamburger, Thomas; Evangeliou, Nikolaos; Stohl, Andreas; von Haustein, Christoph; Thummerer, Severin; Wallner, Christian


    Severe accidents in nuclear power plants such as the historical accident in Chernobyl 1986 or the more recent disaster in the Fukushima Dai-ichi nuclear power plant in 2011 have drastic impacts on the population and environment. Observations and dispersion modelling of the released radionuclides help to assess the regional impact of such nuclear accidents. Modelling the increase of regional radionuclide activity concentrations, which results from nuclear accidents, underlies a multiplicity of uncertainties. One of the most significant uncertainties is the estimation of the source term. That is, the time dependent quantification of the released spectrum of radionuclides during the course of the nuclear accident. The quantification of the source term may either remain uncertain (e.g. Chernobyl, Devell et al., 1995) or rely on estimates given by the operators of the nuclear power plant. Precise measurements are mostly missing due to practical limitations during the accident. The release rates of radionuclides at the accident site can be estimated using inverse modelling (Davoine and Bocquet, 2007). The accuracy of the method depends amongst others on the availability, reliability and the resolution in time and space of the used observations. Radionuclide activity concentrations are observed on a relatively sparse grid and the temporal resolution of available data may be low within the order of hours or a day. Gamma dose rates, on the other hand, are observed routinely on a much denser grid and higher temporal resolution and provide therefore a wider basis for inverse modelling (Saunier et al., 2013). We present a new inversion approach, which combines an atmospheric dispersion model and observations of radionuclide activity concentrations and gamma dose rates to obtain the source term of radionuclides. We use the Lagrangian particle dispersion model FLEXPART (Stohl et al., 1998; Stohl et al., 2005) to model the atmospheric transport of the released radionuclides. The

  9. Examples of NIR based real time release in tablet manufacturing.

    Skibsted, E.; Westerhuis, J.A.; Smilde, A.K.; Witte, D.T.


    Real time release (RTR) of products is a new paradigm in the pharmaceutical industry. An RTR system assures that when the last manufacturing step is passed all the final release criteria are met. Various types of models can be used within the RTR framework. For each RTR system, the monitoring capabi

  10. Measurement of semiochemical release rates with a dedicated environmental control system

    nsect semiochemical dispensers are commonly deployed under variable environmental conditions over a specified time frame; however, predictions of their longevity are hampered by a lack of methods to accurately monitor and predict how the primary variables affect the semiochemical release rate. Herei...

  11. Real-time UV imaging of nicotin release from transdermal patch

    Østergaard, Jesper; Meng-Lund, Emil; Larsen, Susan Weng


    PURPOSE: This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system. METHODS: The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, p...... of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method. CONCLUSION: Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become...

  12. Real-time luminescence imaging of cellular ATP release.

    Furuya, Kishio; Sokabe, Masahiro; Grygorczyk, Ryszard


    Extracellular ATP and other purines are ubiquitous mediators of local intercellular signaling within the body. While the last two decades have witnessed enormous progress in uncovering and characterizing purinergic receptors and extracellular enzymes controlling purinergic signals, our understanding of the initiating step in this cascade, i.e., ATP release, is still obscure. Imaging of extracellular ATP by luciferin-luciferase bioluminescence offers the advantage of studying ATP release and distribution dynamics in real time. However, low-light signal generated by bioluminescence reactions remains the major obstacle to imaging such rapid processes, imposing substantial constraints on its spatial and temporal resolution. We have developed an improved microscopy system for real-time ATP imaging, which detects ATP-dependent luciferin-luciferase luminescence at ∼10 frames/s, sufficient to follow rapid ATP release with sensitivity of ∼10 nM and dynamic range up to 100 μM. In addition, simultaneous differential interference contrast cell images are acquired with infra-red optics. Our imaging method: (1) identifies ATP-releasing cells or sites, (2) determines absolute ATP concentration and its spreading manner at release sites, and (3) permits analysis of ATP release kinetics from single cells. We provide instrumental details of our approach and give several examples of ATP-release imaging at cellular and tissue levels, to illustrate its potential utility.

  13. Timed Release of Valsartan from Programmable Release Capsules: Importance of Plasticizers

    Usha Yogendra Nayak*


    Full Text Available The objective of the present study was to evaluate the effect of different plasticizers on the ethylcellulose coatings of capsules and its timed release characteristics. Various plasticizers such as dibutyl phthalate (DBP, triacetin (TA, glycerol, triethyl citrate (TEC, polyethylene glycol-4000 and polyethylene glycol-6000 (PEG were studied. The physicochemical properties of the casted polymeric films such as mechanical resistance, water uptake and dry weight loss were determined. Also the type and concentration of plasticizer on timed release of the capsule was studied. The drug release was found to be strongly dependent on the type of plasticizer and was in the order of GY>TA>PEG 6000>PEG 4000>TEC>DBP. Capsules coated with hydrophobic DBP (5% showed good release with a lag time of 6 ± 0.5 h. DBP provided mechanically resistant coatings on the capsule and remained within the polymeric films without leaching upon exposure to the release media which helped in maintaining the lag time.

  14. Effect of CaF2 content on rate of fluoride release from filled resins.

    Anusavice, K J; Zhang, N-Z; Shen, C


    Information on the time-dependent release of fluoride from filled resins containing fluoride particles as a function of particle content and solution pH is limited. This study characterized the fluoride ion release from filled resins containing CaF2 particles as a function of filler content and pH. Urethane dimethacrylate and triethylene glycol dimethacrylate resins were used to make filled-resin disks containing 9.09, 23.08, or 33.33 mass% CaF2 filler. Fluoride ion release for the 9.09 mass% concentration was independent of pH. Increasing the filler content from 9.09 to 33.33 mass% increased the fluoride release rate in pH 4.0 buffer solution, because of greater surface degradation. Fluoride ion release from disks stored in pH 6.0 buffer solutions occurred mainly by diffusion from disk surfaces, while fluoride release from disks in pH 4.0 buffers was controlled by diffusion from disk surfaces and degeneration of the resin matrix, which exposed more CaF2 particle surface area.

  15. In Praise of Education as a Time-Release Capsule

    Siegel, David J.


    The modern era of accountability--"Show me what you do matters, and do it quickly"--may discount it, but, according to this author, much of an education worthy of the name acts on "time release." Many of education's effects are gradual; they are also erratic, unpredictable, conditional, circumstantial, and, ultimately, subject to too many matters…

  16. Evaluating High Release Rate MCH (3-Methylcyclohex-2-en-1-one) Treatments for Reducing Dendroctonus pseudotsugae (Coleoptera: Curculionidae) Infestations.

    Brookes, Harrison M; Ross, Darrell W; Strand, Tara M; Thistle, Harold W; Ragenovich, Iral R; Lowrey, Laura L


    Current recommendations for applying the antiaggregation pheromone 3-methylcyclohex-2-en-1-one (MCH) to protect live trees from Douglas-fir beetle, Dendroctonus pseudotsugae Hopkins, infestation are to space individual passive releasers (MCH bubble capsules) on a 12- by 12-m grid throughout areas to be protected. Previous field studies and a theoretical study using a puff dispersion model to predict pheromone concentrations have shown that releasers emitting higher rates of MCH spaced farther apart may be as effective as the established standard treatment. During 2012 and 2013, we tested higher release rates of MCH at correspondingly wider spacings to keep the total amount of MCH released per unit area equal in all treatments. In 2012 near Challis, ID, treatments included the established standard release rate and spacing, four and six times the standard release rate at correspondingly wider spacings, and an untreated control. In 2013 near Ketchum, ID, treatments included the established standard release rate and spacing, five and seven times the standard release rate at correspondingly wider spacings, and an untreated control. Results from both years indicated that all MCH treatments were equally effective in reducing Douglas-fir beetle infestation. Using higher release rate formulations at wider spacings will reduce labor costs of installing MCH treatments, and, in cases where it is necessary, retrieving the releasers as well. In addition to reducing labor costs, the revised treatment protocol may increase the feasibility of treating areas that currently may not be possible due to treatment costs. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email:

  17. Evaluating release alternatives for a long-lived bird species under uncertainty about long-term demographic rates

    Moore, Clinton T.; Converse, Sarah J.; Folk, Martin J.; Runge, Michael C.; Nesbitt, Stephen A.


    The release of animals to reestablish an extirpated population is a decision problem that is often attended by considerable uncertainty about the probability of success. Annual releases of captive-reared juvenile Whooping Cranes (Grus americana) were begun in 1993 in central Florida, USA, to establish a breeding, non-migratory population. Over a 12-year period, 286 birds were released, but by 2004, the introduced flock had produced only four wild-fledged birds. Consequently, releases were halted over managers' concerns about the performance of the released flock and uncertainty about the efficacy of further releases. We used data on marked, released birds to develop predictive models for addressing whether releases should be resumed, and if so, under what schedule. To examine the outcome of different release scenarios, we simulated the survival and productivity of individual female birds under a baseline model that recognized age and breeding-class structure and which incorporated empirically estimated stochastic elements. As data on wild-fledged birds from captive-reared parents were sparse, a key uncertainty that confronts release decision-making is whether captive-reared birds and their offspring share the same vital rates. Therefore, we used data on the only population of wild Whooping Cranes in existence to construct two alternatives to the baseline model. The probability of population persistence was highly sensitive to the choice of these three models. Under the baseline model, extirpation of the population was nearly certain under any scenario of resumed releases. In contrast, the model based on estimates from wild birds projected a high probability of persistence under any release scenario, including cessation of releases. Therefore, belief in either of these models suggests that further releases are an ineffective use of resources. In the third model, which simulated a population Allee effect, population persistence was sensitive to the release decision

  18. Time Rate Gradient Effects and Negative Mass

    Miksch, Edmond


    The Harvard tower Experiment and tests with accurate atomic clocks show that a clock at a high elevation indicates more elapsed time than a clock at a low elevation, both clocks properly measuring time at their locations. This fact mandates that Newton's first law of motion be rewritten to cite impulse balance rather than force balance. Time rate gradient effects explain how the weight of a precisely vertical and precisely uniform electric field or a precisely vertical and precisely uniform magnetic field is supported in a precisely unidirectional gravitational field. Time rate gradient effects also explain how the weight of a unidirectional gravitational field is reacted. It is confirmed that the mass density of the gravitational field is negative.;;

  19. Modulation of Tenoxicam release from hydrophilic matrix: modulator membrane versus rate-controlling membrane.

    El-Nabarawi, Mohamed Ahmed


    This paper describes the preparation of two layered device comprising of tenoxicam containing layer and a drug free membrane layer based on Geomatrix Technology. Our device based on bilaminated films which produced by a casting/solvent evaporation technique. The drug-hydroxypropyl methylcellulose (HPMC) layer was covered by drug free membrane layer composed of a mixture of different ratios of HPMC and ethyl cellulose (EC). The prepared devices were evaluated for thickness, weight, drug content uniformity, water absorption capacity and in-vitro drug release. The films were also evaluated for appearance, smoothness and transparency. The influence of drug free membrane layer composition and thickness on the drug release pattern was studied on 12 devices (D1 to D12). The results indicate that, the release of drug from HPMC matrixes without the drug free membrane layer was fast and follows diffusion controlled mechanism. The release of drug from the devices D1, D4, D9 and D12 follow the same mechanism, while the release of drug from other devices become linear with time (zero order) and extended for long time especially when thickness and the ratio of EC was increased in the drug free membrane layer. From this study it is concluded that, changing the geometry of drug layer by addition of drug free membrane layer and changing its composition and thickness plays an important role in determining whether the drug free membrane layer is rate-controlling or modulator membrane. Hence it can facilitate the development of different pharmaceutical products with different release pattern.

  20. The timing statistics of spontaneous calcium release in cardiac myocytes.

    Mesfin Asfaw

    Full Text Available A variety of cardiac arrhythmias are initiated by a focal excitation that disrupts the regular beating of the heart. In some cases it is known that these excitations are due to calcium (Ca release from the sarcoplasmic reticulum (SR via propagating subcellular Ca waves. However, it is not understood what are the physiological factors that determine the timing of these excitations at both the subcellular and tissue level. In this paper we apply analytic and numerical approaches to determine the timing statistics of spontaneous Ca release (SCR in a simplified model of a cardiac myocyte. In particular, we compute the mean first passage time (MFPT to SCR, in the case where SCR is initiated by spontaneous Ca sparks, and demonstrate that this quantity exhibits either an algebraic or exponential dependence on system parameters. Based on this analysis we identify the necessary requirements so that SCR occurs on a time scale comparable to the cardiac cycle. Finally, we study how SCR is synchronized across many cells in cardiac tissue, and identify a quantitative measure that determines the relative timing of SCR in an ensemble of cells. Using this approach we identify the physiological conditions so that cell-to-cell variations in the timing of SCR is small compared to the typical duration of an SCR event. We argue further that under these conditions inward currents due to SCR can summate and generate arrhythmogenic triggered excitations in cardiac tissue.

  1. Implementation of Releasing Time to Care - the productive ward.

    Wilson, Gwyneth


    This paper describes the implementation of the NHS Institute for Innovation and Improvement Productive Ward - releasing time to care programme. It will discuss the benefits and key successes and provides advice for those wishing to implement the programme. In Lord Darzi's Next Stage Review, he advocates an ambitious vision of patient centred - clinician led, locally driven NHS. The Releasing Time to Care programme is a unique opportunity for everyone working within the NHS to improve effectiveness, safety and reliability of the services we provide. Whilst being situated within a National Health Service policy environment learning from this work can be translated nationally and internationally, as the principles underpin the provision of high quality care. Evaluation is currently in relation to each of the 15 modules rather than as the programme as a whole. It uses various methods including audit, observation, activity follow through, satisfaction surveys and process mapping. Each month data is colated for each of the 11 metrics which has shown a reduction in falls, drug administration errors and improvement in the recording of patient observations. One of the key issues is that an essential component for the success of the programme lies in the tangible support of the Trust Board/Board of Directors. Evidence shows that this programme improves patient satisfaction as it enables the provision of an increase in direct patient care by staff and subsequently improved clinical and safety outcomes. Ward Sister/Charge Nurse development includes Leadership, Project management and Lean Methodology techniques. The Releasing Time to Care programme is a key component of the Next Stage Review. It will create productive organisations by being a catalyst for the transformation of Trust services, enabling staff to spend more time caring for patients and users. This release in time will result in better outcomes and subsequent improvement with patient and staff satisfaction and

  2. A new time-independent formulation of fractional release

    Ostermöller, Jennifer; Bönisch, Harald; Jöckel, Patrick; Engel, Andreas


    The fractional release factor (FRF) gives information on the amount of a halocarbon that is released at some point into the stratosphere from its source form to the inorganic form, which can harm the ozone layer through catalytic reactions. The quantity is of major importance because it directly affects the calculation of the ozone depletion potential (ODP). In this context time-independent values are needed which, in particular, should be independent of the trends in the tropospheric mixing ratios (tropospheric trends) of the respective halogenated trace gases. For a given atmospheric situation, such FRF values would represent a molecular property.We analysed the temporal evolution of FRF from ECHAM/MESSy Atmospheric Chemistry (EMAC) model simulations for several halocarbons and nitrous oxide between 1965 and 2011 on different mean age levels and found that the widely used formulation of FRF yields highly time-dependent values. We show that this is caused by the way that the tropospheric trend is handled in the widely used calculation method of FRF.Taking into account chemical loss in the calculation of stratospheric mixing ratios reduces the time dependence in FRFs. Therefore we implemented a loss term in the formulation of the FRF and applied the parameterization of a mean arrival time to our data set.We find that the time dependence in the FRF can almost be compensated for by applying a new trend correction in the calculation of the FRF. We suggest that this new method should be used to calculate time-independent FRFs, which can then be used e.g. for the calculation of ODP.

  3. Convex quadratic programming relaxations for parallel machine scheduling with controllable processing times subject to release times

    ZHANG Feng; CHEN Feng; TANG Guochun


    Scheduling unrelated parallel machines with controllable processing times subject to release times is investigated. Based on the convex quadratic programming relaxation and the randomized rounding strategy, a 2-approximation algorithm is obtained for a special case with the all-or-none property and then a 3-approximation algorithm is presented for general problem.

  4. Magnetic Reconnection Rates and Energy Release in a Confined X-class Flare

    Veronig, A M


    We study the energy-release process in the confined X1.6 flare that occurred on 22 October 2014 in AR 12171. Magnetic-reconnection rates and reconnection fluxes are derived from three different data sets: space-based data from the Atmospheric Imaging Assembly (AIA) 1600 {\\AA} filter onboard the Solar Dynamics Observatory (SDO) and ground-based H$\\alpha$ and Ca II K filtergrams from Kanzelh\\"ohe Observatory. The magnetic-reconnection rates determined from the three data sets all closely resemble the temporal profile of the hard X-rays measured by the Ramaty High Energy Solar Spectroscopic Imager (RHESSI), which are a proxy for the flare energy released into high-energy electrons. The total magnetic-reconnection flux derived lies between $4.1 \\times 10^{21}$ Mx (AIA 1600 {\\AA}) and $7.9 \\times 10^{21}$ Mx (H$\\alpha$), which corresponds to about 2 to 4% of the total unsigned flux of the strong source AR. Comparison of the magnetic-reconnection flux dependence on the GOES class for 27 eruptive events collected fr...

  5. 75 FR 66057 - Waybill Data Released in Three-Benchmark Rail Rate Proceedings


    ... Surface Transportation Board 49 CFR Part 1244 Waybill Data Released in Three-Benchmark Rail Rate... Board is republishing its April 2, 2010 proposal to amend its rules with respect to the Three-Benchmark... rationale and regulatory objectives. This proposal provides for release to the parties to a...

  6. 28 CFR 523.12 - Work/study release good time.


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Work/study release good time. 523.12..., CLASSIFICATION, AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.12 Work/study release good time. Extra good time for an inmate in work or study release programs is awarded automatically, beginning on...

  7. Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica.

    Van Speybroeck, Michiel; Mellaerts, Randy; Mols, Raf; Thi, Thao Do; Martens, Johan Adriaan; Van Humbeeck, Jan; Annaert, Pieter; Van den Mooter, Guy; Augustijns, Patrick


    The aim of the present study was to evaluate the effect of release rate from ordered mesoporous silica materials on the rate and extent of absorption of the poorly soluble drug fenofibrate. Three ordered mesoporous silica materials with different pore diameter (7.3 nm, 4.4 nm and 2.7 nm) were synthesized and loaded with fenofibrate via impregnation. Release experiments were conducted under sink conditions and under supersaturating conditions in biorelevant media, simulating the fasted and the fed state. Subsequently, all silica-based formulations were evaluated in vivo (rat model). The release experiments under sink conditions indicated a clear increase in release rate with increasing pore size. However, under supersaturating conditions (FaSSIF), the, pharmaceutical performance (in terms of both the degree and duration of supersaturation), increased with decreasing pore size. The same trend was observed in vivo (fasted state): the area under the plasma concentration-time profile amounted to 102 ± 34 μMh, 86 ± 19 μMh and 20 ± 13 μMh for the materials with pore diameter of 2.7 nm, 4.4 nm and 7.3 nm, respectively. The results of this, study demonstrate that a decrease in drug release rate - and thus, a decrease of the rate at which supersaturation is created - is beneficial to the absorption of fenofibrate. Copyright © 2010 Elsevier B.V. All rights reserved.

  8. Experimental study on new monitoring method of radon release rate from uranium tailings

    Fu Jin; HanYaozHao; He Wen Xing; Zhang Biao


    Two new monitoring methods of radon release rate from uranium tailings are introduced. They are the active carbon absorption and gamma energy spectrum method. The instrument and sampler of active carbon absorption is presented with the manufacture, function, performance and calibration, the conditional test of the method and its measuring contrast to that of local static method. One-year continuous in-site monitoring of radon release rate of uranium tailings was done. The annual change regularity of radon release rate from uranium tailings was observed. The optimum season and condition of monitoring the annual average radon release rate are summarized. The parameter monitoring, calculating method and experimentation of gamma energy spectrum method is discussed

  9. Effective rates of heavy metal release from alkaline wastes--quantified by column outflow experiments and inverse simulations.

    Wehrer, Markus; Totsche, Kai Uwe


    Column outflow experiments operated at steady state flow conditions do not allow the identification of rate limited release processes. This requires an alternative experimental methodology. In this study, the aim was to apply such a methodology in order to identify and quantify effective release rates of heavy metals from granular wastes. Column experiments were conducted with demolition waste and municipal waste incineration (MSWI) bottom ash using different flow velocities and multiple flow interruptions. The effluent was analyzed for heavy metals, DOC, electrical conductivity and pH. The breakthrough-curves were inversely modeled with a numerical code based on the advection-dispersion equation with first order mass-transfer and nonlinear interaction terms. Chromium, Copper, Nickel and Arsenic are usually released under non-equilibrium conditions. DOC might play a role as carrier for those trace metals. By inverse simulations, generally good model fits are derived. Although some parameters are correlated and some model deficiencies can be revealed, we are able to deduce physically reasonable release-mass-transfer time scales. Applying forward simulations, the parameter space with equifinal parameter sets was delineated. The results demonstrate that the presented experimental design is capable of identifying and quantifying non-equilibrium conditions. They show also that the possibility of rate limited release must not be neglected in release and transport studies involving inorganic contaminants.

  10. Electrochemical Corrosion Studies for Modeling Metallic Waste Form Release Rates

    Poineau, Frederic [Univ. of Nevada, Las Vegas, NV (United States); Tamalis, Dimitri [Florida Memorial Univ., Miami Gardens, FL (United States)


    The isotope 99Tc is an important fission product generated from nuclear power production. Because of its long half-life (t1/2 = 2.13 ∙ 105 years) and beta-radiotoxicity (β⁻ = 292 keV), it is a major concern in the long-term management of spent nuclear fuel. In the spent nuclear fuel, Tc is present as an alloy with Mo, Ru, Rh, and Pd called the epsilon-phase, the relative amount of which increases with fuel burn-up. In some separation schemes for spent nuclear fuel, Tc would be separated from the spent fuel and disposed of in a durable waste form. Technetium waste forms under consideration include metallic alloys, oxide ceramics and borosilicate glass. In the development of a metallic waste form, after separation from the spent fuel, Tc would be converted to the metal, incorporated into an alloy and the resulting waste form stored in a repository. Metallic alloys under consideration include Tc–Zr alloys, Tc–stainless steel alloys and Tc–Inconel alloys (Inconel is an alloy of Ni, Cr and iron which is resistant to corrosion). To predict the long-term behavior of the metallic Tc waste form, understanding the corrosion properties of Tc metal and Tc alloys in various chemical environments is needed, but efforts to model the behavior of Tc metallic alloys are limited. One parameter that should also be considered in predicting the long-term behavior of the Tc waste form is the ingrowth of stable Ru that occurs from the radioactive decay of 99Tc (99Tc → 99Ru + β⁻). After a geological period of time, significant amounts of Ru will be present in the Tc and may affect its corrosion properties. Studying the effect of Ru on the corrosion behavior of Tc is also of importance. In this context, we studied the electrochemical behavior of Tc metal, Tc-Ni alloys (to model Tc-Inconel alloy) and Tc-Ru alloys in acidic media. The study of Tc-U alloys has also been performed in order to better understand the

  11. Effect of Starch Sources on the Release Rates of Herbicides Encapsulated


    The effects of starch sources on the behaviors of starch matrices and on the rates of herbicides released from the matrices were studied for slow release. The starches considered include native corn starch, wheat starch, potato starch and cassava starch. The matrices were prepared through encapsulating 2,4-dichlorophenoxyacetic or 2,4,5-trichlorophenoxyacetic acids as model herbicides with hot-gelatinized starch pastes. The encapsulation was evaluated in terms of herbicide content, swellability, encapsulation efficiency, and release rate. The results show that starch sources play an important role on the matrix behaviors and on release rates. The rate of 2,4-D released follows the order: wheat starch < potato starch < corn starch < cassava starch. And for the rate of 2,4,5-T, this order is nearly the same only with an exception that the late two kinds of starch are similar. It is also demonstrated that herbicides with different water solubility show different release rates, no matter what type of starch is used as the matrices.

  12. Effects of the rate of releases from Sam Rayburn Reservoir on the Aeration Capacity of the Angelina River, eastern Texas

    Rawson, Jack; Goss, Richard L.; Rathbun, Ira G.


    A three-phase study was conducted during July and August 1979 to determine the effects of varying release rates through the power-outlet works at Sam Rayburn Reservoir, eastern Texas, on aeration capacity of a 14-mile reach of the Angelina River below Sam Rayburn Dam. The dominant factors that affected the aeration capacity during the study time were time of travel and the dissolved-oxygen deficit of the releases. Aeration was low throughout the study but increased in response to increases in the dissolved-oxygen deficit and the duration of time that the releases were exposed to the atmosphere (time of travel). The average concentration of dissolved oxygen sustained by release of 8,800 cubic feet per second decreased from 5.0 milligrams per liter at a site near the power outlet to 4.8 milligrams per liter at a site about 14 miles downstream; the time of travel averaged about 8 hours. The average concentration of dissolved oxygen in flow sustained by releases of 2,200 cubic feet per second increased from 5.2 to 5.5 milligrams per liter; the time of travel averaged about 20 hours. (USGS)

  13. Time-dependent histamine release from stored human blood products

    Nielsen, Hans Jørgen; Edvardsen, L; Vangsgaard, K;


    storage. Whole blood (six units), plasma-reduced whole blood (six units), and plasma- and buffy coat-reduced (saline-adenine-glucose-mannitol) (SAGM) blood (six units) from unpaid healthy donors were stored in the blood bank for 35 days at 4 degrees C. Plasma histamine and total cell-bound histamine......Perioperative transfusion of whole blood has been shown to amplify trauma-induced immunosuppression, which could be attenuated by perioperative administration of histamine2 receptor antagonists. Supernatants from different blood products were, therefore, analysed for histamine content during.......0 (range 176.0-910.0) nmol/l in whole blood and 475.0 (range 360.0-1560.0) nmol/l in plasma-reduced whole blood, while it was undetectable in SAGM blood. Spontaneous histamine release increased in a time-dependent manner from a median of 6.7 (range 2.2-17.4) nmol/l at the time of storage to 175.0 (range 33...

  14. Levonorgestrel release rates over 5 years with the Liletta® 52-mg intrauterine system.

    Creinin, Mitchell D; Jansen, Rolf; Starr, Robert M; Gobburu, Joga; Gopalakrishnan, Mathangi; Olariu, Andrea


    To understand the potential duration of action for Liletta®, we conducted this study to estimate levonorgestrel (LNG) release rates over approximately 5½years of product use. Clinical sites in the U.S. Phase 3 study of Liletta collected the LNG intrauterine systems (IUSs) from women who discontinued the study. We randomly selected samples within 90-day intervals after discontinuation of IUS use through 900days (approximately 2.5years) and 180-day intervals for the remaining duration through 5.4years (1980days) to evaluate residual LNG content. We also performed an initial LNG content analysis using 10 randomly selected samples from a single lot. We calculated the average ex vivo release rate using the residual LNG content over the duration of the analysis. We analyzed 64 samples within 90-day intervals (range 6-10 samples per interval) through 900days and 36 samples within 180-day intervals (6 samples per interval) for the remaining duration. The initial content analysis averaged 52.0±1.8mg. We calculated an average initial release rate of 19.5mcg/day that decreased to 17.0, 14.8, 12.9, 11.3 and 9.8mcg/day after 1, 2, 3, 4 and 5years, respectively. The 5-year average release rate is 14.7mcg/day. The estimated initial LNG release rate and gradual decay of the estimated release rate are consistent with the target design and function of the product. The calculated LNG content and release rate curves support the continued evaluation of Liletta as a contraceptive for 5 or more years of use. Liletta LNG content and release rates are comparable to published data for another LNG 52-mg IUS. The release rate at 5years is more than double the published release rate at 3years with an LNG 13.5-mg IUS, suggesting continued efficacy of Liletta beyond 5years. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. A smoothed stochastic earthquake rate model considering seismicity and fault moment release for Europe

    Hiemer, S.; Woessner, J.; Basili, R.; Danciu, L.; Giardini, D.; Wiemer, S.


    We present a time-independent gridded earthquake rate forecast for the European region including Turkey. The spatial component of our model is based on kernel density estimation techniques, which we applied to both past earthquake locations and fault moment release on mapped crustal faults and subduction zone interfaces with assigned slip rates. Our forecast relies on the assumption that the locations of past seismicity is a good guide to future seismicity, and that future large-magnitude events occur more likely in the vicinity of known faults. We show that the optimal weighted sum of the corresponding two spatial densities depends on the magnitude range considered. The kernel bandwidths and density weighting function are optimized using retrospective likelihood-based forecast experiments. We computed earthquake activity rates (a- and b-value) of the truncated Gutenberg-Richter distribution separately for crustal and subduction seismicity based on a maximum likelihood approach that considers the spatial and temporal completeness history of the catalogue. The final annual rate of our forecast is purely driven by the maximum likelihood fit of activity rates to the catalogue data, whereas its spatial component incorporates contributions from both earthquake and fault moment-rate densities. Our model constitutes one branch of the earthquake source model logic tree of the 2013 European seismic hazard model released by the EU-FP7 project `Seismic HAzard haRmonization in Europe' (SHARE) and contributes to the assessment of epistemic uncertainties in earthquake activity rates. We performed retrospective and pseudo-prospective likelihood consistency tests to underline the reliability of our model and SHARE's area source model (ASM) using the testing algorithms applied in the collaboratory for the study of earthquake predictability (CSEP). We comparatively tested our model's forecasting skill against the ASM and find a statistically significant better performance for

  16. Timing of translocation influences birth rate and population dynamics in a forest carnivore

    Facka, Aaron N; Lewis, Jeffrey C.; Happe, Patricia; Jenkins, Kurt J.; Callas, Richard; Powell, Roger A.


    Timing can be critical for many life history events of organisms. Consequently, the timing of management activities may affect individuals and populations in numerous and unforeseen ways. Translocations of organisms are used to restore or expand populations but the timing of translocations is largely unexplored as a factor influencing population success. We hypothesized that the process of translocation negatively influences reproductive rates of individuals that are moved just before their birthing season and, therefore, the timing of releases could influence translocation success. Prior to reintroducing fishers (Pekania pennanti) into northern California and onto the Olympic Peninsula of Washington, we predicted that female fishers released in November and December (early) would have a higher probability of giving birth to kits the following March or April than females released in January, February, and March (late), just prior to or during the period of blastocyst implantation and gestation. Over four winters (2008–2011), we translocated 56 adult female fishers that could have given birth in the spring immediately after release. Denning rates, an index of birth rate, for females released early were 92% in California and 38% in Washington. In contrast, denning rates for females released late were 40% and 11%, in California and Washington, a net reduction in denning rate of 66% across both sites. To understand how releasing females nearer to parturition could influence population establishment and persistence, we used stochastic population simulations using three-stage Lefkovitch matrices. These simulations showed that translocating female fishers early had long-term positive influences on the mean population size and on quasi-extinction thresholds compared to populations where females were released late. The results from both empirical data and simulations show that the timing of translocation, with respect to life history events, should be considered during

  17. Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets.

    Khamanga, Sandile M; Walker, Roderick B


    Tablets manufactured in-house were compared to a marketed sustained-release product of verapamil to investigate the rate of hydration, erosion, and drug-release mechanism by measuring the wet and subsequent dry weights of the products. Swelling and erosion rates depended on the polymer and granulating fluid used, which ultimately pointed to their permeability characteristics. Erosion rate of the marketed product was highest, which suggests that the gel layer that formed around these tablets was weak as opposed to the robust and resistant layers of test products. Anomalous and near zero-order transport mechanisms were dominant in tests and commercial product, respectively.

  18. 75 FR 16712 - Waybill Data Released in Three-Benchmark Rail Rate Proceedings


    ... TRANSPORTATION Surface Transportation Board 49 CFR Part 1244 Waybill Data Released in Three-Benchmark Rail Rate... Board proposes to amend its rules with respect to the Three-Benchmark methodology used to adjudicate... simplified stand-alone cost approach for medium-size rail rate disputes and revising its...

  19. Production and release rate of (37)Ar from the UT TRIGA Mark-II research reactor.

    Johnson, Christine; Biegalski, Steven R; Artnak, Edward J; Moll, Ethan; Haas, Derek A; Lowrey, Justin D; Aalseth, Craig E; Seifert, Allen; Mace, Emily K; Woods, Vincent T; Humble, Paul


    Air samples were taken at various locations around The University of Texas at Austin's TRIGA Mark II research reactor and analyzed to determine the concentrations of (37)Ar, (41)Ar, and (133)Xe present. The measured ratio of (37)Ar/(41)Ar and historical records of (41)Ar releases were then utilized to estimate an annual average release rate of (37)Ar from the reactor facility. Using the calculated release rate, atmospheric transport modeling was performed in order to determine the potential impact of research reactor operations on nearby treaty verification activities. Results suggest that small research reactors (∼1 MWt) do not release (37)Ar in concentrations measurable by currently proposed OSI detection equipment.

  20. Measuring water-borne cortisol in Poecilia latipinna:is the process stressful, can stress be minimized and is cortisol correlated with sex steroid release rates?

    Gabor, C R; Contreras, A


    The stress of water-borne hormone collection process was examined in sailfin mollies Poecilia latipinna. Baseline release rates of the stress hormone cortisol were measured and minimum confinement time for water sampling was evaluated for a standard 60 min v. a 30 min protocol. A 30 min hormone collection period reflects release rates over 60 min. Potential stress response to confinement in the beaker for the water-borne collection process was tested over 4 days. There was no evidence of stress due to the collection methods, as cortisol release rates did not differ significantly across four sequential days of handling for P. latipinna. Males and females did not differ significantly in baseline cortisol release rates. Baseline cortisol release rates from fish immediately after being collected in the field were also not significantly different than those in the 4 day confinement experiment. After exposure to a novel environment, however, P. latipinna mounted a stress response. Stress may also affect sex steroids and behaviour but cortisol release rates were not significantly correlated with sex steroids [11-ketotestosterone (KT), testosterone, or oestradiol], or mating attempts. The correlation between water-borne release rates and plasma steroid levels was validated for both cortisol and KT. Finally, normalizing cortisol release rates using standard length in lieu of mass is viable and accurate. Water-borne hormone assays are a valuable tool for investigating questions concerning the role of hormones in mediating stress responses and reproductive behaviours in P. latipinna and other livebearing fishes.

  1. Irrigation timing and fertilizer rate in peppers

    Excessive rain fall might leach nutrients from the soil or cause producers to not supply irrigation to pepper (Capsicum sp.). Fertilizer at 150 or 300 lb/acre of triple 17 NPK, the lower rate is the recommended rate, was supplied to either bell, cv. Jupiter, or non-pungent jalapeno, cv. Pace 105, pe...

  2. Increased survival rate by local release of diclofenac in a murine model of recurrent oral carcinoma

    Will OM


    determination of tumor recurrence. At the end of 7 weeks following tumor resection, 33% of mice with diclofenac-loaded scaffolds had a recurrent tumor, in comparison to 90%–100% of the mice in the other three groups. At this time point, mice with diclofenac-releasing scaffolds showed 89% survival rate, while the other groups showed survival rates of 10%–25%. Immunohistochemical staining of recurrent tumors revealed a near 10-fold decrease in the proliferation marker Ki-67 in the tumors derived from mice with diclofenac-releasing scaffolds. In summary, the local application of diclofenac in an orthotopic mouse tumor resection model of oral cancer reduced tumor recurrence with significant improvement in survival over a 7-week study period following tumor resection. Local drug release of anti-inflammatory agents should be investigated as a therapeutic option in the prevention of tumor recurrence in oral squamous carcinoma. Keywords: tumor recurrence, oral squamous cell carcinoma, head and neck cancer, NSAIDs, drug releasing polymers, mouse model 

  3. Applying Learning Analytics to Investigate Timed Release in Online Learning

    Martin, Florence; Whitmer, John C.


    Adaptive learning gives learners control of context, pace, and scope of their learning experience. This strategy can be implemented in online learning by using the "Adaptive Release" feature in learning management systems. The purpose of this study was to use learning analytics research methods to explore the extent to which the adaptive…

  4. Metal release rate from AISI 316L stainless steel and pure Fe, Cr and Ni into a synthetic biological medium--a comparison.

    Herting, G; Wallinder, I Odnevall; Leygraf, C


    Metal release rates from stainless steel grade 316L were investigated in artificial lysosomal fluid (ALF), simulating a human inflammatory cell response. The main focus was placed on release rates of main alloying elements using graphite furnace atomic absorption spectroscopy, and changes in surface oxide composition by means of X-ray photoelectron spectroscopy. To emphasise that alloys and pure metals possess totally different intrinsic properties, comparative studies were performed on the pure alloying constituents: iron, nickel and chromium. Significant differences in release rates were observed due to the presence of a passive surface film on stainless steel. Iron and nickel were released at rates more than 300 times lower from the 316L alloy compared with the pure metals whereas the release rate of chromium was similar. Iron was preferentially released compared with nickel and chromium. Immersion in ALF resulted in the gradual enrichment of chromium in the surface film, a small increase of nickel, and the reduction of oxidized iron with decreasing release rates of alloy constituents as a result. As expected, released metals from stainless steel grade 316L were neither in proportion to the bulk alloy composition nor to the surface film composition.

  5. Relationship between in vivo skin blanching and in vitro release rate for betamethasone valerate creams.

    Shah, V P; Elkins, J; Skelly, J P


    Betamethasone valerate creams from two firms were evaluated using the skin blanching procedure. In both studies, the same cream formulation exhibited significantly higher blanching compared to the other product. An in vitro release rate was determined for these betamethasone valerate cream products using a diffusion cell system, with a cellulose acetate membrane and a 60% ethanol:water receptor medium. The release rate (flux) of betamethasone valerate was higher for the higher blanching formulation and was statistically different from the other product. The integrity of the cellulose acetate membrane in 60% ethanol:water mixture was ascertained using hydrocortisone cream product. The in vitro drug release method, using a diffusion cell system and a synthetic membrane, can serve as a good quality control test method for topical creams.

  6. Calculating the rate of exothermic energy release for catalytic converter efficiency monitoring

    Hepburn, J.S.; Meitzler, A.H. [Ford Motor Co., Dearborn, MI (United States)


    This paper reports on the development of a new methodology for OBD-II catalyst efficiency monitoring. Temperature measurements taken from the center of the catalyst substrate or near the exterior surface of the catalyst brick were used in conjunction with macroscopic energy balances to calculate the instantaneous rate of exothermic energy generation within the catalyst. The total calculated rate of exothermic energy release over the FTP test cycle was within 10% of the actual or theoretical value and provided a good indicator of catalyst light-off for a variety of aged catalytic converters. Normalization of the rate of exothermic energy release in the front section of the converter by the mass flow rate of air inducted through the engine was found to provide a simple yet practical means of monitoring the converter under both FTP and varying types of road driving.

  7. Release rates of Al from inorganic and organic compounds in a sandy podzol, during laboratory experiments

    Salm, van der C.; Westerveld, J.W.; Verstraten, J.M.


    Research with respect to release rates of Al and Al concentrations in the soil solution has led to two contrasting hypotheses, stressing either the importance of kinetically constrained dissolution reactions or the role of complexation of Al to soil organic matter. The existence of two contrasting

  8. Laboratory experiment to determine phosphate release rates from sediments of a formerly oligotrophic lake (Silbersee, Cuxhaven)

    Elmarami, Hatem; Greskowiak, Janek; Hamann, Enrico; Massmann, Gudrun


    The Silbersee is a small, formerly oligotrophic lake in northwestern Germany which still contains rare character species for oligotrophic lakes (Isoëtes lacustris, Littorella uniflora) threatened by eutrophication. It was suspected that the lake sediments and the redox conditions in the hypolimnon play an important role with regard to eutrophication, potentially releasing phosphorus (P) into the water column. This was the motivation to conduct experiments to estimate the release rate of phosphorus into the lake. It had been noted that the P concentrations in the bottom water were higher during summer in the stagnation phase, when conditions turned sulfidic. Eight sediment cores were taken with a Mondsee-corer (manufactured by UWITEC) at different sites of the lake. The thickness of the sediment within the cores ranged from 15cm to 35 cm and were overlying by approximately 40cm of lake water water. The headspace was approximately 10cm. The cores were stored in a fridge first under oxic, then under anoxic conditions as observed in the lake bottom water in the different seasons. Redox conditions were maintained by bubbling with oxygen and nitrogen gas during the respective time periods. During the experiment, the temperature was held constant to match the water temperature measured at the bottom of the lake (~ 7±1°C). Concentrations of total phosphorus (TP) and dissolved phosphorus (DP), iron (Fe) and dissolved oxygen (DO) as well as pH were measured under oxic and anoxic conditions in the water column. The results showed that TP, DP and Fe concentrations were higher under anoxic conditions than under oxic conditions. The observed increase of phosporous in the water column during the anoxic phase was presumably a result of (i) reductive Fe-oxides dissolution and the corresponding loss of sorption sites and (ii) desorption of phosphorous via surface complexation reactions due to pH changes during the experiment.

  9. Measurements of the time constant for steady ionization in shaped-charge barium releases

    Hoch, Edward L.; Hallinan, Thomas J.


    Quantitative measurements of three solar illuminated shaped-charge barium releases injected at small angles to the magnetic field were made using a calibrated color television camera. Two of the releases were from 1989. The third release, a reanalysis of an event included in Hallinan's 1988 study of three 1986 releases, was included to provide continuity between the two studies. Time constants for ionization, measured during the first 25 s of each release, were found to vary considerably. The two 1989 time constants differed substantially, and both were significantly less than any of the 1986 time constants. On the basis of this variability, we conclude that the two 1989 releases showed evidence of continuous nonsolar ionization. One release showed nonsolar ionization which could not he attributed to Alfven's critical ionization velocity process, which requires a component of velocity perpendicular to the magnetic field providing a perpendicular energy greater than the ionization potential.

  10. Fast scan cyclic voltammetry as a novel method for detection of real-time gonadotropin-releasing hormone release in mouse brain slices.

    Glanowska, Katarzyna M; Venton, B Jill; Moenter, Suzanne M


    Pulsatile gonadotropin-releasing hormone (GnRH) release is critical for the central regulation of fertility. There is no method allowing real-time GnRH detection in brain slices. We developed fast-scan cyclic voltammetry (FSCV) using carbon-fiber microelectrodes (CFME) to detect GnRH release and validated it using a biologically relevant system. FSCV parameters (holding potential, switching potential, and scan rate) were determined for stable GnRH detection in vitro, then optimized for GnRH detection in mouse brain slices. Placement of CFMEs in the median eminence (ME) near GnRH terminals allowed detection of both KCl-evoked and spontaneous GnRH release. GnRH release was also detected from GnRH fibers passing near GnRH soma and near fiber-fiber appositions in the preoptic area. No GnRH signal was detected from CFMEs in the ME of hpg mice, which lack GnRH, or in regions not containing GnRH neurons in wild-type mice; application of exogenous GnRH produced a signal similar to that observed for spontaneous/evoked endogenous GnRH release. Using an established mouse model that produces diurnal variations in GnRH neuron activity, we demonstrated corresponding changes in spontaneous GnRH release in the median eminence. These results validate FSCV to detect GnRH in brain slices and provide new information on the sites and amounts of GnRH release, providing insight into its neuromodulatory functions.

  11. The timing of phasic transmitter release is Ca2+-dependent and lacks a direct influence of presynaptic membrane potential.

    Felmy, Felix; Neher, Erwin; Schneggenburger, Ralf


    Ca2+ influx through voltage-gated Ca2+ channels and the resulting elevation of intracellular Ca2+ concentration, [Ca2+]i, triggers transmitter release in nerve terminals. However, it is controversial whether in addition to the opening of Ca2+ channels, membrane potential directly affects transmitter release. Here, we assayed the influence of membrane potential on transmitter release at the calyx of Held nerve terminals. Transmitter release was evoked by presynaptic Ca2+ uncaging, or by presynaptic Ca2+ uncaging paired with presynaptic voltage-clamp depolarizations to +80 mV, under pharmacological block of voltage-gated Ca2+ channels. Such a change in membrane potential did not alter the Ca2+ dependence of transmitter release rates or synaptic delays. We also found, by varying the amount of Ca2+ influx during Ca2+ tail-currents, that the time course of phasic transmitter release is not invariant to changes in release probability. Rather, the time difference between peak Ca2+ current and peak transmitter release became progressively shorter with increasing Ca2+ current amplitude. When this time difference was plotted as a function of the estimated local [Ca2+]i at the sites of vesicle fusion, a slope of approximately 100 micros per 10 microM [Ca2+]i was found, in reasonable agreement with a model of cooperative Ca2+ binding and vesicle fusion. Thus, the amplitude and time course of the [Ca2+]i signal at the sites of vesicle fusion controls the timing and the amount of transmitter release, both under conditions of brief periods of Ca2+ influx, as well as during step-like elevations of [Ca2+]i produced by Ca2+ uncaging.

  12. Single-machine batch scheduling minimizing weighted flow times and delivery costs with job release times

    Amir Ebrahimzadeh Pilerood


    Full Text Available This paper addresses scheduling a set of weighted jobs on a single machine in presence of release date for delivery in batches to customers or to other machines for further processing. The problem is a natural extension of minimizing the sum of weighted flow times by considering the possibility of delivering jobs in batches and introducing batch delivery costs. The classical problem is NP-hard and then the extended version of the problem is NP-hard. The objective function is that of minimizing the sum of weighted flow times and delivery costs. The extended problem arises in a real supply chain network by cooperation between two layers of chain. Structural properties of the problem are investigated and used to devise a branch-and-bound solution scheme. Computational experiments show the efficiency of suggested algorithm for solving instances up to 40 jobs.

  13. Waiting time before release increases the motivation to home in homing pigeons (Columba livia).

    Dell'Ariccia, Gaia; Costantini, David; Dell'Omo, Giacomo; Lipp, Hans-Peter


    When performing homing experiments with individual releases, pigeons have to wait in a transport box for a certain amount of time before being released and hence perceive the departure of companions. Quite often, the last pigeons disappear straightforward from the release site. The question is whether this reflects improved orientation because of prolonged exposure to the release place or whether it reflects increased homing motivation. By releasing pigeons from a familiar site, we investigated the effects of the time spent at the release site on homing performance, recording pigeons' flights with GPS loggers. Our results show that, despite individual peculiarities of flight patterns, the waiting time at release site had a positive effect on homing speed and time, and reduced the time spent circling around the release point. However, the overall path efficiency as derived from GPS tracking was not influenced. These results suggest that a longer waiting time before release improves homing performance and this is related not only to increased navigational abilities but also to increased homing motivation.

  14. A time-release technique for corrosion prevention

    Dry, C.M.; Corsaw, M.J.T. [Univ. of Illinois, Champaign, IL (United States). School of Architecture


    Researchers at the University of Illinois have developed an anti-corrosion system that is activated automatically where and when it is needed. Porous fibers are filled with calcium nitrite and coated with a salt-sensitive substance to control the response. The release of the corrosion inhibitor chemical is at the portion of the reinforcing bar in danger of corrosion when conditions would allow corrosion to initiate. In a series of tests with concrete samples containing either no protection or the conventional freely mixed calcium nitrite, this system performed well in that it delayed the onset of corrosion by at least three weeks in the laboratory specimens and reduced the amount of total corrosion by more than half.

  15. Study on encapsulation of chlorine dioxide in gelatin microsphere for reducing release rate.

    Ci, Ying; Wang, Lin; Guo, Yanchuan; Sun, Ruixue; Wang, Xijie; Li, Jinyou


    This study aims to explore the effects of encapsulation of chlorine dioxide in a hydrophilic biodegradable polymer gelatin to reduce its release rate. An emulsification-coacervation method was adopted. The characterizations of chlorine dioxide-gelatin microspheres were described. Using UV-vis spectrophotometer the λmax of chlorine dioxide was observed at 358 nm. The particle size and distribution of chlorine oxide-gelatin microspheres was measured by a dynamic light scattering (DLS) method, the diameter was (1400~1900) nm. The entrapment of chlorine dioxide-gelatin microspheres was confirmed by IR. The surface morphology, size, and shape of chlorine dioxide-gelatin microspheres were analyzed using Scanning electron microscope (SEM). It showed that the encapsulated microspheres size was around 2000 nm with uniform distribution. The percentage entrapment of chlorine dioxide in the encapsulated samples was about 80~85%. A slow release study of chlorine dioxide from the encapsulated biopolymer (gelatin) in air was also carried out, which showed continuous release up to ten days. It can be concluded that it is possible to make a slow release formulation of ClO2 by entrapped in a hydrophilic biodegradable polymer gelatin. ClO2-gelatin microspheres can stable release low concentration ClO2 gas over an extended period.

  16. Impaired sarcoplasmic reticulum Ca(2+) release rate after fatiguing stimulation in rat skeletal muscle

    Ørtenblad, Niels; Sjøgaard, G; Madsen, Klavs


    to 66% that persisted for 1 h, followed by a gradual recovery to 87% of prefatigue release rate at 3 h recovery. Tetanic force and rate of force development (+dF/dt) and relaxation (-dF/dt) were depressed by approximately 80% after stimulation. Recovery occurred in two phases: an initial phase, in which......The purpose of the study was to characterize the sarcoplasmic reticulum (SR) function and contractile properties before and during recovery from fatigue in the rat extensor digitorum longus muscle. Fatiguing contractions (60 Hz, 150 ms/s for 4 min) induced a reduction of the SR Ca(2+) release rate...... during the first 0.5-1 h the metabolic state recovered to resting levels, and a slow phase from 1-3 h characterized by a rather slow recovery of the mechanical properties. The recovery of SR Ca(2+) release rate was closely correlated to +dF/dt during the slow phase of recovery (r(2) = 0.51; P

  17. Variation of strain energy release rate with plate thickness. [fracture mode transition

    Sih, G. C.; Hartranft, R. J.


    An analytical model of a through-thickness crack in a statically stretched plate is presented in which the crack front stress state is permitted to vary in the direction of the plate thickness. The amplitude or intensity of this stress field can be made nearly constant over a major portion of the interior crack front which is in a state of plane strain. The average amount of work available for extending a small segment of the crack across the thickness is associated with an energy release rate quantity in a manner similar to the two-dimensional Griffith crack model. The theoretically calculated energy release rate is shown to increase with increasing plate thickness, indicating that available work for crack extension is higher in a thicker plate.

  18. Diurnal fluctuations in root oxygen release rate and dissolved oxygen budget in wetland mesocosm

    Dong, C.; Zhu, W; Zhao, Y. Q.; Gao, M


    To assess the role of plants for oxygen offering in constructed wetlands, this study experimentally evaluated the amount of root oxygen release rate using mass balance method. The mass balance calculation is based on the following components: respiratory oxygen consumption of the roots; oxygen required for degradation of the organic matters; oxygen required for nitrification; and the amount of dissolved oxygen in the influent, effluent and substrate water. Experimental results have demonstrat...

  19. Study on encapsulation of chlorine dioxide in gelatin microsphere for reducing release rate

    Ci, Ying; Wang,Lin; Guo, YanChuan; Sun, Ruixue; Wang, Xijie; Li, Jinyou


    Objective: This study aims to explore the effects of encapsulation of chlorine dioxide in a hydrophilic biodegradable polymer gelatin to reduce its release rate. Methods: An emulsification-coacervation method was adopted. The characterizations of chlorine dioxide-gelatin microspheres were described. Using UV-vis spectrophotometer the λmax of chlorine dioxide was observed at 358 nm. The particle size and distribution of chlorine oxide-gelatin microspheres was measured by a dynamic light scatte...

  20. A methodology to study cyclic debond growth at constant mode-mixity and energy release rate

    Quispitupa, Amilcar; Berggreen, Christian; Carlsson, Leif A.


    It is well known that face/core debond crack propagation is governed by the critical energy release rate (fracture toughness) and mode-mixity at the crack tip. Thus, the current study focuses on the developing of a methodology to perform fatigue crack growth experiments of debonded sandwich...... and better control of loading conditions at the crack tip will be the most relevant outcomes of using the proposed fatigue test method....

  1. The Effects of Different Amounts of Controlled Release Fertilizer on the Root Growth and the Filling Rate in Winter Wheat

    Meng Li; Jingtian Yang; Liyuan Yan; Yan Shi


    In order to increase the fertilizer use efficiency and yield in winter wheat, the effects of controlled release fertilizer on the root growth and the filling rate in winter wheat by applying different amounts of controlled release fertilizer had been studied in open field. The results indicated that conventional complex fertilizer and controlled release fertilizer could cause corresponding changes of the wheat root activity, dry root weight, root-shoot ratio and filling rate, but the fertiliz...

  2. The Effects of Different Amounts of Controlled Release Fertilizer on the Root Growth and the Filling Rate in Winter Wheat

    Meng Li; Jingtian Yang; Liyuan Yan; Yan Shi


    In order to increase the fertilizer use efficiency and yield in winter wheat, the effects of controlled release fertilizer on the root growth and the filling rate in winter wheat by applying different amounts of controlled release fertilizer had been studied in open field. The results indicated that conventional complex fertilizer and controlled release fertilizer could cause corresponding changes of the wheat root activity, dry root weight, root-shoot ratio and filling rate, but the fertiliz...

  3. The effect of inorganic cations Ca2+ and Al3+ on the release rate of propranolol hydrochloride from sodium carboxymethylcellulose matrices

    G Mohammadi


    Full Text Available Background and purpose of the study: Several methods are available for control release of propranolol hydrochloride (PLH. The aim of the present study was to develop a novel technique to sustain PLH release from matrices. Materials and methods: Matrices of PLH containing sodium carboxymethylcellulose (Na CMC and various amounts of the inorganic cations Ca2+ and Al3+ were prepared. Dissolution of the matrices was carried out using the USP apparatus I. Analysis of release data was performed by some model independent and dependent approaches.    Results: The release of PLH was affected by incorporation of different amounts (milliequivalents, meq of Ca2+ and Al3+. When the Ca2+amount increased from 0- 0.375 meq, the fraction of PLH which released within 480 min was augmented from 0.74 to 1 apparently via disintegrating effect of the cation. Al3+in the range 0- 0.125 meq, decreased the fractional release from 0.74 to 0.37 presumably by in situ cross- linking with polymer. Al3+ between 0.125 and 0.5 meq enhanced the release from 0.37 to 1 possibly due to the disintegrating effect. Among model independent metrics, the mean release time (MRT failed to represent the effect of the cations on the release but the release efficiency (RE as well as a suggested mean release rate (MRR correlated well with the experimental release rate. Due to the complexity of the release, the only suitable kinetic model was the Weibull distribution. The minimum and maximum Weibull release rate constants for matrices containing Al3+ were 0.0007-0.017 1/min. The corresponding values for the matrices with Ca2+ were 0.0029-0.0082 1/min. Conclusion: Through careful choice of the amount of Al3+in NaCMC matrices the release of PLH can be controlled at a desired rate. The best model independent approach is MRR and the most accurate model dependent method is Weibull distribution to describe the release data.

  4. Study on release rate of latent heat in Czochralski silicon growth

    REN Bingyan; YANG Jiankun; LI Yanlin; LIU Xiaoping; WANG Minhua


    The pulling rate in czochralski silicon (CZSi) growth is important for reducing the cost of solar cell.In this paper, double-heater, heat shield and composite argon duct system were introduced in the Ф450 mm hot zone of a Czochralski furnace.The pulling rate under different thermal system was recorded in experiments.Argon flow and temperature fields were simulated by finite element method(FEM).Experimental results and numerical simulation indicate that double-heater and composite argon duct system can enhance obviously the release rate of latent heat.In Φ 200 mm Czochralski silicon (CZSi) growth, average pulling rate can increase from 0.6 mm·min-1 in the conventional hot zone to 0.8 mm·min-1 in the modified hot zone.

  5. Self-rating of daily time management in children: psychometric properties of the Time-S.

    Sköld, Annika; Janeslätt, Gunnel Kristina


    Impaired ability to manage time has been shown in several diagnoses common in childhood. Impaired ability involves activities and participation domain (daily time management, DTM) and body function and structure domain (time-processing ability, TPA). DTM needs to be evaluated from an individual's own perspective. To date, there has been a lack of self-rating instruments for children that focus on DTM. The aim of this study is to describe psychometric properties of Time-S when used in children aged 10-17 years with a diagnosis of ADHD, Autism, CP or mild ID. Further, to test whether TPA correlates with self-rated DTM. Eighty-three children aged 10-17 years participated in the study. Rasch analysis was used to assess psychometric properties. Correlation analysis was performed between Time-S and a measure of TPA. The 21 items of the Time-S questionnaire fit into a unitary construct measuring self-perceived daily management of an individual's time. A non-significant, small correlation was found between TPA and DTM. The results indicate good psychometric properties for the questionnaire. The questionnaire is potentially useful in intervention planning and evaluation.

  6. Studies on the codling moth (Lepidoptera: Tortricidae) response to different codlemone release rates.

    Vacas, S; Miñarro, M; Bosch, M D; Primo, J; Navarro-Llopis, V


    The response of the codling moth (Cydia pomonella L. (Lepidoptera: Tortricidae)) to different emission values of its main pheromone component, 8E,10E-dodecadien-1-ol (codlemone), was investigated in three field trials conducted in plots without mating disruption treatments. Moth catches obtained in traps baited with pheromone dispensers were correlated with the corresponding codlemone release rates by multiple regression analysis. In a preliminary trial conducted in Lleida (NE Spain), a decreasing trend of captures was observed based on increasing pheromone levels. After this, the pheromone release profiles of the pheromone dispensers were studied, in parallel with the field trials, by residual codlemone extraction and gas chromatography quantification. In the trials carried out in Asturias (NW Spain), a correlation between trap catches and emission levels (within the range from 11 to 1,078 μg/d) was found and fitted a logarithmic model. Captures followed a decreasing linear trend in the range of emission rates from 11 to 134 μg/d. Given that release values comprised between 11 and 67 μg/d did not lead to significantly different catches in traps, this emission range could be considered to develop effective formulations for attraction purposes when mating disruption is not acting in the environment.


    Sabera eKhatun


    Full Text Available In recent years natural polymers have been widely used, because of their effectiveness and availability over synthetic polymers. In this present investigation matrix tablets of Metformin hydrochloride were formulated using Water hyacinth powder and its rate retardant activity was studied. Tablets were prepared using wet granulation method with 8% starch as granulating agent and 5%, 10%, 15%, 20%, 25% and 30% of Water hyacinth powder to the drug. In preformulation study, angle of repose, Carr’s Index and Hausner ratio were calculated. Fourier Transform Infrared Spectroscopy (FTIR, Differential Scanning Calorimetry (DSC and Scanning Electron Microscopy (SEM studies were performed and no interactions were found between drug and excipients. Weight variation, friability, hardness, thickness, diameter, and in vitro release study were performed with the prepared matrix tablets. Dissolution studies were conducted using USP type II apparatus at a speed of 100 rpm at 37oC ± 0.5 temperature, for 8 hours. All the formulations comply with both BP and USP requirements, but among all the formulations F-1 (5% of Water hyacinth was the best fitted formula. The drug release patterns were explained in different kinetic models such as Zero order, First order, Higuchi, Hixson Crowell and Korsmeyer-Peppas equations. The current investigation implies that Water hyacinth has the potential to be used as a rate-retarding agent in sustained release drug formulations.

  8. Release of native and amended boron from arid zone soils after varying incubation times

    In this study we evaluated the boron (B) release from soils containing elevated native B and examined the extent to which incubation time affected B release. Five soils varying in initial pH and clay content were selected for the study. The soils were spiked with five varying doses of B as H3BO3 (...

  9. Real-time imaging of inflation-induced ATP release in the ex vivo rat lung.

    Furuya, Kishio; Tan, Ju Jing; Boudreault, Francis; Sokabe, Masahiro; Berthiaume, Yves; Grygorczyk, Ryszard


    Extracellular ATP and other nucleotides are important autocrine/paracrine mediators that regulate diverse processes critical for lung function, including mucociliary clearance, surfactant secretion, and local blood flow. Cellular ATP release is mechanosensitive; however, the impact of physical stimuli on ATP release during breathing has never been tested in intact lungs in real time and remains elusive. In this pilot study, we investigated inflation-induced ATP release in rat lungs ex vivo by real-time luciferin-luciferase (LL) bioluminescence imaging coupled with simultaneous infrared tissue imaging to identify ATP-releasing sites. With LL solution introduced into air spaces, brief inflation of such edematous lung (1 s, ∼20 cmH2O) induced transient (lungs and provides the first direct evidence of inflation-induced ATP release in lung air spaces and in pulmonary blood capillaries, highlighting the importance of purinergic signaling in lung function. Copyright © 2016 the American Physiological Society.

  10. The International Pulsar Timing Array: First Data Release

    Verbiest, J P W; Hobbs, G; van Haasteren, R; Demorest, P B; Janssen, G H; Wang, J -B; Desvignes, G; Caballero, R N; Keith, M J; Champion, D J; Arzoumanian, Z; Babak, S; Bassa, C G; Bhat, N D R; Brazier, A; Brem, P; Burgay, M; Burke-Spolaor, S; Chamberlin, S J; Chatterjee, S; Christy, B; Cognard, I; Cordes, J M; Dai, S; Dolch, T; Ellis, J A; Ferdman, R D; Fonseca, E; Gair, J R; Garver-Daniels, N E; Gentile, P; Gonzalez, M E; Graikou, E; Guillemot, L; Hessels, J W T; Jones, G; Karuppusamy, R; Kerr, M; Kramer, M; Lam, M T; Lasky, P D; Lassus, A; Lazarus, P; Lazio, T J W; Lee, K J; Levin, L; Liu, K; Lynch, R S; Lyne, A G; Mckee, J; McLaughlin, M A; McWilliams, S T; Madison, D R; Manchester, R N; Mingarelli, C M F; Nice, D J; Oslowski, S; Palliyaguru, N T; Pennucci, T T; Perera, B B P; Perrodin, D; Possenti, A; Petiteau, A; Ransom, S M; Reardon, D; Rosado, P A; Sanidas, S A; Sesana, A; Shaifullah, G; Shannon, R M; Siemens, X; Simon, J; Smits, R; Spiewak, R; Stairs, I H; Stappers, B W; Stinebring, D R; Stovall, K; Swiggum, J K; Taylor, S R; Theureau, G; Tiburzi, C; Toomey, L; Vallisneri, M; van Straten, W; Vecchio, A; Wang, Y; Wen, L; You, X P; Zhu, W W; Zhu, X -J


    The highly stable spin of neutron stars can be exploited for a variety of (astro-)physical investigations. In particular arrays of pulsars with rotational periods of the order of milliseconds can be used to detect correlated signals such as those caused by gravitational waves. Three such "Pulsar Timing Arrays" (PTAs) have been set up around the world over the past decades and collectively form the "International" PTA (IPTA). In this paper, we describe the first joint analysis of the data from the three regional PTAs, i.e. of the first IPTA data set. We describe the available PTA data, the approach presently followed for its combination and suggest improvements for future PTA research. Particular attention is paid to subtle details (such as underestimation of measurement uncertainty and long-period noise) that have often been ignored but which become important in this unprecedentedly large and inhomogeneous data set. We identify and describe in detail several factors that complicate IPTA research and provide r...

  11. LEAK: A source term generator for evaluating release rates from leaking vessels

    Clinton, J.H.


    An interactive computer code for estimating the rate of release of any one of several materials from a leaking tank or broken pipe leading from a tank is presented. It is generally assumed that the material in the tank is liquid. Materials included in the data base are acetonitrile, ammonia, carbon tetrachloride, chlorine, chlorine trifluoride, fluorine, hydrogen fluoride, nitric acid, nitrogen tetroxide, sodium hydroxide, sulfur hexafluoride, sulfuric acid, and uranium hexafluoride. Materials that exist only as liquid and/or vapor over expected ranges of temperature and pressure can easily be added to the data base file. The Fortran source code for LEAK and the data file are included with this report.


    HU, T.A.


    Flammable gases such as hydrogen, ammonia, and methane are observed in the tank dome space of the Hanford Site high-level waste tanks. This report assesses the steady-state flammability level under normal and off-normal ventilation conditions in the tank dome space for 177 double-shell tanks and single-shell tanks at the Hanford Site. The steady-state flammability level was estimated from the gas concentration of the mixture in the dome space using estimated gas release rates, Le Chatelier's rule and lower flammability limits of fuels in an air mixture. A time-dependent equation of gas concentration, which is a function of the gas release and ventilation rates in the dome space, has been developed for both soluble and insoluble gases. With this dynamic model, the time required to reach the specified flammability level at a given ventilation condition can be calculated. In the evaluation, hydrogen generation rates can be calculated for a given tank waste composition and its physical condition (e.g., waste density, waste volume, temperature, etc.) using the empirical rate equation model provided in Empirical Rate Equation Model and Rate Calculations of Hydrogen Generation for Hanford Tank Waste, HNF-3851. The release rate of other insoluble gases and the mass transport properties of the soluble gas can be derived from the observed steady-state gas concentration under normal ventilation conditions. The off-normal ventilation rate is assumed to be natural barometric breathing only. A large body of data is required to do both the hydrogen generation rate calculation and the flammability level evaluation. For tank waste that does not have sample-based data, a statistical-based value from probability distribution regression was used based on data from tanks belonging to a similar waste group. This report (Revision 3) updates the input data of hydrogen generation rates calculation for 177 tanks using the waste composition information in the Best-Basis Inventory Detail

  13. Do Declining Discount Rates lead to Time Inconsistent Economic Advice?

    Hansen, Anders Chr.


    This paper addresses the risk of time inconsistency in economic appraisals related to the use of hyperbolic discounting (declining discount rates) instead of exponential discounting (constant discount rate). Many economists are uneasy about the prospects of potential time inconsistency. The paper...

  14. Study on the optimum pheromone release rate for attraction of Chilo suppressalis (Lepidoptera: Pyralidae).

    Vacas, Sandra; Alfaro, Cristina; Navarro-Llopis, Vicente; Zarzo, Manuel; Primo, Jaime


    Traditional chemical control against Chilo suppressalis Walker is currently being replaced in Spain by new methods based on pheromones. A key step to improve the efficacy of these methods is the determination of the optimum pheromone release rate, which is still uncertain for this pest. In this work, the pheromone release profile and the field performance of a new mesoporous dispenser was compared with a standard commercial dispenser. For this purpose, pheromone loads were extracted from field-aged dispensers and quantified by gas chromatography with flame ionization detector. In addition, a field trial was carried out with traps baited with one, two, or three mesoporous dispensers per trap, as well as with traps containing one standard dispenser. We found that the highest number of field catches did not correspond to the highest pheromone emission rate, which suggests a repellent effect of the insect if the emission is excessive. The results suggest that the attractant activity was maximized by emitting approximately 34 microg/d. The efficacy of the mesoporous dispenser and its possible improvements are discussed.

  15. Energy-release rate and mode mixity of face/core debonds in sandwich beams

    Kardomateas, George A.; Berggreen, Christian; Carlsson, Leif A.


    Closed-form algebraic expressions for the energy-release rate and the mode mixity are obtained for a debonded sandwich (trimaterial). The most general case of an "asymmetric" sandwich is considered (i.e., the bottom face sheet not necessarily of the same material or thickness as the top facesheet......).The energy-release rate is obtained by use of the J-integral,and the expression is derived interms of the forces and moments at the debond section.Regarding the mode mixity, a closed-form expression is derived in terms of the geometry, material, and applied loading, and it is proven that, in the trimaterial...... case, just as in the bimaterial case, the mode mixity can be obtained in terms of a single scalar quantityω,which is independent of loading;theωvalue for a particular geometry and material can be extracted from a numerical solution for one loading combination. Thus, this analysis extends the existing...

  16. Time scale bias in erosion rates of glaciated landscapes.

    Ganti, Vamsi; von Hagke, Christoph; Scherler, Dirk; Lamb, Michael P; Fischer, Woodward W; Avouac, Jean-Philippe


    Deciphering erosion rates over geologic time is fundamental for understanding the interplay between climate, tectonic, and erosional processes. Existing techniques integrate erosion over different time scales, and direct comparison of such rates is routinely done in earth science. On the basis of a global compilation, we show that erosion rate estimates in glaciated landscapes may be affected by a systematic averaging bias that produces higher estimated erosion rates toward the present, which do not reflect straightforward changes in erosion rates through time. This trend can result from a heavy-tailed distribution of erosional hiatuses (that is, time periods where no or relatively slow erosion occurs). We argue that such a distribution can result from the intermittency of erosional processes in glaciated landscapes that are tightly coupled to climate variability from decadal to millennial time scales. In contrast, we find no evidence for a time scale bias in spatially averaged erosion rates of landscapes dominated by river incision. We discuss the implications of our findings in the context of the proposed coupling between climate and tectonics, and interpreting erosion rate estimates with different averaging time scales through geologic time.

  17. Unexpectedly high catch-and-release rates in European marine recreational fisheries: implications for science and management

    Ferter, Keno; Weltersbach, Marc Simon; Strehlow, Harry Vincent;


    Unexpectedly high catch-and-release rates in European marine recreational fisheries: implications for science and management. – ICES Journal of Marine Science, 70: .While catch-and-release (C&R) is a well-known practice in several European freshwater recreational fisheries, studies on the magnitu...

  18. Sill intrusion driven fluid flow and vent formation in volcanic basins: Modeling rates of volatile release and paleoclimate effects

    Iyer, Karthik; Schmid, Daniel


    Evidence of mass extinction events in conjunction with climate change occur throughout the geological record and may be accompanied by pronounced negative carbon isotope excursions. The processes that trigger such globally destructive changes are still under considerable debate. These include mechanisms such as poisoning from trace metals released during large volcanic eruptions (Vogt, 1972), CO2 released from lava degassing during the formation of Large Igneous Provinces (LIPs) (Courtillot and Renne, 2003) and CH4 release during the destabilization of sub-seafloor methane (Dickens et al., 1995), to name a few. Thermogenic methane derived from contact metamorphism associated with magma emplacement and cooling in sedimentary basins has been recently gaining considerable attention as a potential mechanism that may have triggered global climate events in the past (e.g. Svensen and Jamtveit, 2010). The discovery of hydrothermal vent complexes that are spatially associated with such basins also supports the discharge of greenhouse gases into the atmosphere (e.g. Jamtveit et al., 2004; Planke et al., 2005; Svensen et al., 2006). A previous study that investigated this process using a fluid flow model (Iyer et al., 2013) suggested that although hydrothermal plume formation resulting from sill emplacement may indeed release large quantities of methane at the surface, the rate at which this methane is released into the atmosphere is too slow to trigger, by itself, some of the negative δ13C excursions observed in the fossil record over short time scales observed in the fossil record. Here, we reinvestigate the rates of gas release during sill emplacement in a case study from the Harstad Basin off-shore Norway with a special emphasis on vent formation. The presented study is based on a seismic line that crosses multiple sill structures emplaced around 55 Ma within the Lower Cretaceous sediments. A single well-defined vent complex is interpreted above the termination of the

  19. The Effect of Synthetic Brine Constituents on the Rate of Arsenic Release from Arsenopyrite

    Parthasarathy, H.; Dzombak, D. A.; Karamalidis, A.


    Geologic carbon dioxide storage (GCS) in deep saline sedimentary formations is a potential method for mitigating increased levels of atmospheric CO2. Injection of CO2 in those formations may induce dissolution of reservoir minerals. Leakage of CO2-saturated brines and native brines could impact overlying drinking water aquifers by contaminating them with toxic constituents. Of particular concern is the effect of CO2 on the rates of dissolution of arsenic and other toxic metals from reservoir minerals. The most common pure phase arsenic mineral in sedimentary geologic formations is arsenopyrite (FeAsS). Natural brines have high salinities (up to 7M), with high concentrations of Na+, Ca2+, Mg2+ and K+. The focus of this study is to examine the effect of brine components on the dissolution rate of arsenic from arsenopyrite. A small-scale flow-through column system was constructed for this purpose and is being used to measure arsenic release rates from arsenopyrite. Influent solutions of NaCl, CaCl2, and MgCl2 at equal ionic strengths were used to examine the effect of the cationic species. A cleaning procedure to remove prior surface oxidation on the surface of the arsenopyrite particles was also developed. Preliminary results with NaCl and CaCl2 at an ionic strength of 0.011M indicate that the rate of dissolution of arsenic is dependent on the cationic species but independent of ionic strength.

  20. Effect of flow rate and lead/copper pipe sequence on lead release from service lines.

    Cartier, Clément; Arnold, Roger B; Triantafyllidou, Simoni; Prévost, Michèle; Edwards, Marc


    A pilot experiment examined lead leaching from four representative configurations of service lines including: (1) 100% lead (Pb), (2) 100% copper (Cu), (3) 50% Pb upstream of 50% Cu, and (4) 50% Pb-downstream of 50% Cu using a range of flow rates. The cumulative mass of lead release indicated that a typical partial replacement configuration (50% lead downstream of copper) did not provide a net reduction in lead when compared to 100% lead pipe (85 mg for 50% Pb-downstream versus 83 mg for 100%-Pb) due to galvanic and deposition corrosion. The partially replaced service line configuration also had a much greater likelihood of producing water with "spikes" of lead particulates at higher flow rates, while tending to produce lower levels of lead at very low flow rates. After the first 214 days the galvanic current between copper and lead was only reduced by 34%, proving that galvanic impacts can be highly persistent even in water with optimized corrosion control by dosing of zinc orthophosphate. Finally, this experiment raises concern about the low flow rates used during some prior home sampling events, which may underestimate exposure to lead during normal water use, especially when galvanic Pb:Cu connections are present.

  1. On reevaluation rate in discrete time Hogg-Huberman model

    Tanaka, Toshijiro; Shibata, Junko; Inoue, Masayoshi


    The discrete time Hogg-Huberman model is extended to a case with time-dependent reevaluation rate at which agents using one resource decide to evaluate their resource choice. In this paper the time dependence of the reevaluation rate is determined by states of the system. The dynamical behavior of the extended Hogg-Huberman model is discussed. It is found that the change of fraction of agents using resource 1 is suppressed to be smaller than that in the case of constant reevaluation rate.

  2. A Note on Two-Agent Scheduling with Resource Dependent Release Times on a Single Machine

    Peng Liu


    Full Text Available We consider a scheduling problem in which both resource dependent release times and two agents exist simultaneously. Two agents share a common single machine, and each agent wants to minimize a cost function dependent on its own jobs. The release time of each A-agent’s job is related to the amount of resource consumed. The objective is to find a schedule for the problem of minimizing A-agent’s total amount of resource consumption with a constraint on B-agent’s makespan. The optimal properties and the optimal polynomial time algorithm are proposed to solve the scheduling problem.

  3. Groundwater flow analysis and dose rate estimates from releases to wells at a coastal site

    Kattilakoski, E.; Suolanen, V. [VTT Energy, Espoo (Finland)


    {sup 3}/a. Due to the placing of the shallow wells in the discharge areas, the dilution calculated in the shallow well was shown to be close to that calculated in the deep well. In conservative considerations the value around 90 000 m{sup 3}/a can be regarded as a representative expectation value of the effective dilution of the well. This dilution volume value was also suggested by the most realistic modelling approach of the groundwater flow analysis. It was used as basis when calculating the nuclide specific dose conversion factors (DCF's) for the drinking water pathway. The DCF's were calculated for unit release rates (1 Bq/a) and the assumed water consumption rate was 2 litres/day. (orig.)

  4. Rate-embedded differential space-time-frequency coding scheme


    In multiple-input-multiple-output orthogonal-frequency-division-multiplexing (MIMO-OFDM) system, a rate-embedded differential space-time-frequency (DSTF) coding scheme was proposed. Both the conventional space-time codes and coding techniques in frequency domain were employed to build high rate and low rate space-time-frequency message matrices. Then both types of message matrices were differentially transmitted alternately in the frequency domain. Consequently, the total transmission rate could be improved greatly. At receiver, a simple decision feedback differential detector (SDF-DD) was adopted to further enhance the total error performance with approximate DD complexity. Simulation results verified that the proposed scheme can implement high rate and high reliability differential transmission. Compared with the conventional DSTF coding schemes, the proposed scheme achieves higher spectral efficiency and much better error performance.

  5. The Effects of Different Amounts of Controlled Release Fertilizer on the Root Growth and the Filling Rate in Winter Wheat

    Meng Li


    Full Text Available In order to increase the fertilizer use efficiency and yield in winter wheat, the effects of controlled release fertilizer on the root growth and the filling rate in winter wheat by applying different amounts of controlled release fertilizer had been studied in open field. The results indicated that conventional complex fertilizer and controlled release fertilizer could cause corresponding changes of the wheat root activity, dry root weight, root-shoot ratio and filling rate, but the fertilizer of conventional fertilizer performed in the pre-stage significantly, controlled release fertilizer performed in the middle and late stage gradually. So mixing conventional fertilizer with controlled release fertilizer can ensure the nutrient supply of whole growth and development of wheat to explore the most appropriate collocation dosage. This will make fertilizer and economic benefits achieve the best.

  6. Stock Market Capitalisation and Interest Rate in Nigeria: A Time ...

    Stock Market Capitalisation and Interest Rate in Nigeria: A Time Series Analysis. ... PROMOTING ACCESS TO AFRICAN RESEARCH ... Obviously for the Nigerian capital market to enhance economic growth and development and compare ...

  7. Kinetic Energy Release in Fragmentation Processes following Electron Emission: A time dependent approach

    Chiang, Ying-Chih; Meyer, Hans-Dieter; Cederbaum, Lorenz S


    A time-dependent approach for the kinetic energy release (KER) spectrum is developed for a fragmentation of a diatomic molecule after an electronic decay process, e.g. Auger process. It allows one to simulate the time-resolved spectra and provides more insight into the molecular dynamics than the time-independent approach. Detailed analysis of the time-resolved emitted electron and KER spectra sheds light on the interrelation between wave packet dynamics and spectra.

  8. Impact of Eudragit EPO and hydroxypropyl methylcellulose on drug release rate, supersaturation, precipitation outcome and redissolution rate of indomethacin amorphous solid dispersions.

    Xie, Tian; Gao, Wei; Taylor, Lynne S


    The purpose of this work was to evaluate the impact of polymer(s) on the dissolution rate, supersaturation and precipitation of indomethacin amorphous solid dispersions (ASD), and to understand the link between precipitate characteristics and redissolution kinetics. The crystalline and amorphous solubilities of indomethacin were determined in the absence and presence of hydroxypropylmethyl cellulose (HPMC) and/or Eudragit (®) EPO to establish relevant phase boundaries. At acidic pH, HPMC could maintain supersaturation of the drug by effectively inhibiting solution crystallization while EPO increased both the crystalline and amorphous solubility of the drug, but did not inhibit crystallization. The HPMC dispersion dissolved relatively slowly without undergoing crystallization while the supersaturation generated by rapid dissolution of the EPO ASD was short-lived due to crystallization. The crystals thus generated underwent rapid redissolution upon pH increase, dissolving faster than the reference crystalline material, and at a comparable rate to the amorphous HPMC dispersion. A ternary dispersion containing both EPO and HPMC dissolved rapidly, generating an apparent drug concentration that exceeded the amorphous solubility of indomethacin, leading to the formation of a new nanosized droplet phase. These nanodroplets dissolved virtually immediately when the pH was increased. In conclusion, the concentration-time profiles achieved from indomethacin ASD dissolution are a complex interplay of drug release rate, precipitation kinetics and outcome, and precipitate redissolution rate, whereby each of these processes is highly dependent on the polymer(s) employed in the formulation. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Finite Block-Length Achievable Rates for Queuing Timing Channels


    The exponential server timing channel is known to be the simplest, and in some sense canonical, queuing timing channel. The capacity of this infinite-memory channel is known. Here, we discuss practical finite-length restrictions on the codewords and attempt to understand the amount of maximal rate that can be achieved for a target error probability. By using Markov chain analysis, we prove a lower bound on the maximal channel coding rate achievable at blocklength $n$ and error probability $...

  10. Teaching About Rates and Time: Challenges and Resources

    Ormand, C. J.; Manduca, C. A.; Semken, S. C.; Crespi, E.


    An understanding of geologic time is fundamental for all students in geoscience courses. Determining the rates of geoscience processes and dates of key events lie at the heart of much of geoscience research. Concepts associated with how geoscientists determine rates and dates are difficult for students to learn and challenging for instructors to teach. Further, intellectual grounding in the magnitudes of Deep Time may provide a foundation for understanding large magnitudes in other contexts, including astrophysics, evolutionary biology, and economics. In February, 2012, an NSF-funded 'On the Cutting Edge' workshop brought together 32 geoscience faculty, education and cognitive science researchers, and faculty from other STEM disciplines to develop an understanding of the cognitive challenges in learning temporal concepts and to share successful strategies for teaching about rates and time. Workshop participants developed a robust set of online resources for faculty teaching about rates and time, including web pages about learning goals for our students, assessing student learning about time, what research tells us about using analogies to teach about time, and teaching about geochronology. Each participant also contributed to SERC's online collections of courses, teaching activities, visualizations, and other instructional resources for teaching temporal concepts. Workshop participants concluded that understanding geologic time and rates is essential, not only for geoscientists, but also for scientists in other disciplines, such as biology and astronomy, and generally for citizens of the planet. Moreover, assessment of student understanding of temporal concepts is challenging, but essential. Participants also discussed the cognitive challenges involved in understanding geologic time and strategies for overcoming these challenges. While there has not been much research on best practices in teaching about Deep Time, there are many promising strategies taken from

  11. Numerical Studies on Heat Release Rate in Room Fire on Liquid Fuel under Different Ventilation Factors

    N. Cai


    Full Text Available Heat release rate (HRR of the design fire is the most important parameter in assessing building fire hazards. However, HRR in room fire was only studied by computational fluid dynamics (CFD in most of the projects determining fire safety provisions by performance-based design. In contrast to ten years ago, officers in the Far East are now having better knowledge of CFD. Two common questions are raised on CFD-predicted results on describing free boundaries; and on computing grid size. In this work, predicting HRR by the CFD model was justified with experimental room pool fire data reported earlier. The software fire dynamics simulator (FDS version 5 was selected as the CFD simulation tool. Prescribed input heating rate based on the experimental results was used with the liquid fuel model in FDS. Five different free boundary conditions were investigated to predict HRR. Grid sensitivity study was carried out using one stretched mesh and multiple uniform meshes with different grid sizes. As it is difficult to have the entire set of CFD predicted results agreed with experiments, macroscopic flow parameters on the mass flow rate through door opening predicted by CFD were also justified by another four conditions with different ventilation factors.

  12. Global rates of mantle serpentinization and H2 release at oceanic transform faults

    Ruepke, Lars; Hasenclever, Joerg


    The cycling of seawater through the ocean floor is the dominant mechanism of biogeochemical exchange between the solid earth and the global ocean. Crustal fluid flow appears to be typically associated with major seafloor structures, and oceanic transform faults (OTF) are one of the most striking yet poorly understood features of the global mid-ocean ridge systems. Fracture zones and transform faults have long been hypothesized to be sites of substantial biogeochemical exchange between the solid Earth and the global ocean. This is particularly interesting with regard to the ocean biome. Deep ocean ecosystems constitute 60% of it but their role in global ocean biogeochemical cycles is much overlooked. There is growing evidence that life is supported by chemosynthesis at hydrothermal vents but also in the crust, and therefore this may be a more abundant process than previously thought. In this context, the serpentine forming interaction between seawater and cold lithospheric mantle rocks is particularly interesting as it is also a mechanism of abiotic hydrogen and methane formation. Interestingly, a quantitative global assessment of mantle serpentinization at oceanic transform faults in the context of the biogeochemical exchange between the seafloor and the global ocean is still largely missing. Here we present the results of a set of 3-D thermo-mechanical model calculations that investigate mantle serpentinization at OTFs for the entire range of globally observed slip rates and fault lengths. These visco-plastic models predict the OTF thermal structure and the location of crustal-scale brittle deformation, which is a prerequisite for mantle serpentinization to occur. The results of these simulations are integrated with information on the global distribution of OTF lengths and slip rates yielding global estimates on mantle serpentinization and associated H2 release. We find that OTFs are potentially sites of intense crustal fluid flow and are in terms of H2 release

  13. Adhesive-Bonded Composite Joint Analysis with Delaminated Surface Ply Using Strain-Energy Release Rate

    Chadegani, Alireza; Yang, Chihdar; Smeltzer, Stanley S. III


    This paper presents an analytical model to determine the strain energy release rate due to an interlaminar crack of the surface ply in adhesively bonded composite joints subjected to axial tension. Single-lap shear-joint standard test specimen geometry with thick bondline is followed for model development. The field equations are formulated by using the first-order shear-deformation theory in laminated plates together with kinematics relations and force equilibrium conditions. The stress distributions for the adherends and adhesive are determined after the appropriate boundary and loading conditions are applied and the equations for the field displacements are solved. The system of second-order differential equations is solved to using the symbolic computation tool Maple 9.52 to provide displacements fields. The equivalent forces at the tip of the prescribed interlaminar crack are obtained based on interlaminar stress distributions. The strain energy release rate of the crack is then determined by using the crack closure method. Finite element analyses using the J integral as well as the crack closure method are performed to verify the developed analytical model. It has been shown that the results using the analytical method correlate well with the results from the finite element analyses. An attempt is made to predict the failure loads of the joints based on limited test data from the literature. The effectiveness of the inclusion of bondline thickness is justified when compared with the results obtained from the previous model in which a thin bondline and uniform adhesive stresses through the bondline thickness are assumed.

  14. Inferring time derivatives including cell growth rates using Gaussian processes

    Swain, Peter S.; Stevenson, Keiran; Leary, Allen; Montano-Gutierrez, Luis F.; Clark, Ivan B. N.; Vogel, Jackie; Pilizota, Teuta


    Often the time derivative of a measured variable is of as much interest as the variable itself. For a growing population of biological cells, for example, the population's growth rate is typically more important than its size. Here we introduce a non-parametric method to infer first and second time derivatives as a function of time from time-series data. Our approach is based on Gaussian processes and applies to a wide range of data. In tests, the method is at least as accurate as others, but has several advantages: it estimates errors both in the inference and in any summary statistics, such as lag times, and allows interpolation with the corresponding error estimation. As illustrations, we infer growth rates of microbial cells, the rate of assembly of an amyloid fibril and both the speed and acceleration of two separating spindle pole bodies. Our algorithm should thus be broadly applicable.

  15. Real-time detection of acetylcholine release from the human endocrine pancreas.

    Rodriguez-Diaz, Rayner; Dando, Robin; Huang, Y Anthony; Berggren, Per-Olof; Roper, Stephen D; Caicedo, Alejandro


    Neurons, sensory cells and endocrine cells secrete neurotransmitters and hormones to communicate with other cells and to coordinate organ and system function. Validation that a substance is used as an extracellular signaling molecule by a given cell requires a direct demonstration of its secretion. In this protocol we describe the use of biosensor cells to detect neurotransmitter release from endocrine cells in real-time. Chinese hamster ovary cells expressing the muscarinic acetylcholine (ACh) receptor M3 were used as ACh biosensors to record ACh release from human pancreatic islets. We show how ACh biosensors loaded with the Ca(2+) indicator Fura-2 and pressed against isolated human pancreatic islets allow the detection of ACh release. The biosensor approach is simple; the Ca(2+) signal generated in the biosensor cell reflects the presence (release) of a neurotransmitter. The technique is versatile because biosensor cells expressing a variety of receptors can be used in many applications. The protocol takes ∼3 h.

  16. Electrospun micelles/drug-loaded nanofibers for time-programmed multi-agent release.

    Yang, Guang; Wang, Jie; Li, Long; Ding, Shan; Zhou, Shaobing


    Combined therapy with drugs of different therapeutic effects is an effective way in the treatment of diseases and damaged tissues or organs. However, how to precisely control the release order, dose, and time of the drugs using vehicles is still a challenging task. In this work, for the first time, a study to develop a nanoscale multi-drug delivery system based on polymer micelle-enriched electrospun nanofibers is presented. The multi-drug delivery system is achieved, first, by the fabrication of hydrophobic curcumin encapsulated micelles assembled from biodegradable mPEG-PCL copolymer and, second, by the blending of the micelle powder with hydrophilic doxorubicin in polyvinyl alcohol solution, followed by simply electrospinning this combination. Due to the different domains of the two drugs within the nanofibers, the release behaviors show a time-programmed release, and can be temporally and spatially regulated. In vitro tumor cell inhibition assay indicates that the delivery system possesses great potential in cancer chemotherapy.

  17. The effects of heart rate and aiming time on performance in Turkish National Archery Team

    İpek Eroğlu Kolayiş


    Full Text Available The purpose of this study is to investigate the effects of aiming time and heart rate on the performance. Three elite female national subject was used in this study. The shooting performance was observed only in 70 m. To evaluate heart rate, Delta Plus CP/I portable, interpreting model ECG, to determine  the releasing time double channel ME 3000 micro-processor, Muscle Tester were used. The results of the study; the shooting heart rate is116,2±7,16 bpm., aiming time is 3,56±0,59 s. And the heart rate of the time between two shooting  is 113,13±9,54 bpm. According to statistical analysis, a significant difference between shooting HR and aiming time of arrows which hit the different point on the target has been observed (p<0,05.The relationships between shooting HR-performance and shooting HR-Aiming time have been observed.While shootings come close to the center of the target (through the 10 point the shooting heart rate and aiming time has decreased and there is no change in the value of the heart rate of the time between two shooting.

  18. The effects of heart rate and aiming time on performance in Turkish National Archery Team

    İpek Eroğlu Kolayiş


    Full Text Available The purpose of this study is to investigate the effects of aiming time and heart rate on the performance. Three elite female national subject was used in this study. The shooting performance was observed only in 70 m. To evaluate heart rate, Delta Plus CP/I portable, interpreting model ECG, to determine the releasing time double channel ME 3000 micro-processor, Muscle Tester were used. The results of the study; the shooting heart rate is116,2±7,16 bpm., aiming time is 3,56±0,59 s. And the heart rate of the time between two shooting is 113,13±9,54 bpm. According to statistical analysis, a significant difference between shooting HR and aiming time of arrows which hit the different point on the target has been observed (p<0,05.The relationships between shooting HR-performance and shooting HR-Aiming time have been observed.While shootings come close to the center of the target (through the 10 point the shooting heart rate and aiming time has decreased and there is no change in the value of the heart rate of the time between two shooting.

  19. Quantification of Kinetic Rate Law Parameters of Uranium Release from Sodium Autunite as a Function of Aqueous Bicarbonate Concentrations

    Gudavalli, Ravi; Katsenovich, Yelena; Wellman, Dawn M.; Lagos, Leonel; Tansel, Berrin


    ABSTRACT: Hydrogen carbonate is one of the most significant components within the uranium geochemical cycle. In aqueous solutions, hydrogen carbonate forms strong complexes with uranium. As such, aqueous bicarbonate may significantly increase the rate of uranium release from uranium minerals. Quantifying the relationship of aqueous hydrogen carbonate solutions to the rate of uranium release during dissolution is critical to understanding the long-term fate of uranium within the environment. Single-pass flow-through (SPTF) experiments were conducted to estimate the rate of uranium release from Na meta-autunite as a function of bicarbonate solutions (0.0005-0.003 M) under the pH range of 6-11 and temperatures of 5-60oC. Consistent with the results of previous investigation, the rate of uranium release from sodium autunite exhibited minimal dependency on temperature; but were strongly dependent on pH and increasing concentrations of bicarbonate solutions. Most notably at pH 7, the rate of uranium release exhibited 370 fold increases relative to the rate of uranium release in the absence of bicarbonate. However, the effect of increasing concentrations of bicarbonate solutions on the release of uranium was significantly less under higher pH conditions. It is postulated that at high pH values, surface sites are saturated with carbonate, thus the addition of more bicarbonate would have less effect on uranium release. Results indicate the activation energies were unaffected by temperature and bicarbonate concentration variations, but were strongly dependent on pH conditions. As pH increased from 6 to 11, activation energy values were observed to decrease from 29.94 kJ mol-1 to 13.07 kJ mol-1. The calculated activation energies suggest a surface controlled dissolution mechanism.

  20. The release of dipicolinic acid--the rate-limiting step of Bacillus endospore inactivation during the high pressure thermal sterilization process.

    Reineke, Kai; Schlumbach, Karl; Baier, Daniel; Mathys, Alexander; Knorr, Dietrich


    High pressure combined with elevated temperatures can produce low acid, commercially sterile and shelf-stable foods. Depending on the temperature and pressure levels applied, bacterial endospores pass through different pathways, which can lead to a pressure-induced germination or inactivation. Regardless of the pathway, Bacillus endospores first release pyridine-2,6-dicarboxylic acid (DPA), which contributes to the low amount of free water in the spore core and is consequently responsible for the spore's high resistance against wet and dry heat. This is therefore the rate-limiting step in the high pressure sterilization process. To evaluate the impact of a broad pressure, temperature and time domain on the DPA release, Bacillus subtilis spores were pressure treated between 0.1 and 900 MPa at between 30 and 80 °C under isothermal isobaric conditions during dwell time. DPA quantification was assessed using HPLC, and samples were taken both immediately and 2 h after the pressure treatment. To obtain a release kinetic for some pressure-temperature conditions, samples were collected between 1s and 60 min after decompression. A multiresponse kinetic model was then used to derive a model covering all kinetic data. The isorate lines modeled for the DPA release in the chosen pressure-temperature landscape enabled the determination of three distinct zones. (I) For pressures 50 °C, a 90% DPA release was achievable in less than 5 min and no difference in the amount of DPA was found immediately 2 h after pressurization. This may indicate irreversible damage to the inner spore membrane or membrane proteins. (II) Above 600 MPa the synergism between pressure and temperature diminished, and the treatment temperature alone dominated DPA release. (III) Pressures pressure-induced physiological like germination with cortex degradation, which continues after pressure release. Furthermore, at 600 MPa and 40 °C, a linear relationship was found for the DPA release rate constants ln

  1. Preset time count rate meter using adaptive digital signal processing

    Žigić Aleksandar D.


    Full Text Available Two presented methods were developed to improve classical preset time count rate meters by using adapt able signal processing tools. An optimized detection algorithm that senses the change of mean count rate was implemented in both methods. Three low-pass filters of various structures with adaptable parameters to implement the control of the mean count rate error by suppressing the fluctuations in a controllable way, were considered and one of them implemented in both methods. An adaptation algorithm for preset time interval calculation executed after the low-pass filter was devised and implemented in the first method. This adaptation algorithm makes it possible to obtain shorter preset time intervals for higher stationary mean count rate. The adaptation algorithm for preset time interval calculation executed before the low-pass filter was devised and implemented in the second method. That adaptation algorithm enables sensing of a rapid change of the mean count rate before fluctuations suppression is carried out. Some parameters were fixed to their optimum values after appropriate optimization procedure. Low-pass filters have variable number of stationary coefficients depending on the specified error and the mean count rate. They implement control of the mean count rate error by suppressing fluctuations in a controllable way. The simulated and realized methods, using the developed algorithms, guarantee that the response time shall not exceed 2 s for the mean count rate higher than 2 s-1 and that controllable mean count rate error shall be within the range of ±4% to ±10%.

  2. Static and dynamic strain energy release rates in toughened thermosetting composite laminates

    Cairns, Douglas S.


    In this work, the static and dynamic fracture properties of several thermosetting resin based composite laminates are presented. Two classes of materials are explored. These are homogeneous, thermosetting resins and toughened, multi-phase, thermosetting resin systems. Multi-phase resin materials have shown enhancement over homogenous materials with respect to damage resistance. The development of new dynamic tests are presented for composite laminates based on Width Tapered Double Cantilevered Beam (WTDCB) for Mode 1 fracture and the End Notched Flexure (ENF) specimen. The WTDCB sample was loaded via a low inertia, pneumatic cylinder to produce rapid cross-head displacements. A high rate, piezo-electric load cell and an accelerometer were mounted on the specimen. A digital oscilloscope was used for data acquisition. Typical static and dynamic load versus displacement plots are presented. The ENF specimen was impacted in three point bending with an instrumented impact tower. Fracture initiation and propagation energies under static and dynamic conditions were determined analytically and experimentally. The test results for Mode 1 fracture are relatively insensitive to strain rate effects for the laminates tested in this study. The test results from Mode 2 fracture indicate that the toughened systems provide superior fracture initiation and higher resistance to propagation under dynamic conditions. While the static fracture properties of the homogeneous systems may be relatively high, the apparent Mode 2 dynamic critical strain energy release rate drops significantly. The results indicate that static Mode 2 fracture testing is inadequate for determining the fracture performance of composite structures subjected to conditions such as low velocity impact. A good correlation between the basic Mode 2 dynamic fracture properties and the performance is a combined material/structural Compression After Impact (CAI) test is found. These results underscore the importance of

  3. Times and Sizes of Jumps in the Mexican Interest Rate

    José Antonio Núñez Mora; Arturo Lorenzo Valdés


    This paper examines the role of jumps in a continuous-time short-term interest rate model for Mexico. A filtering algorithm provides estimates of jumps times and sizes in the time series of Mexican cetes for the 1998-2006 period. The empirical results indicate that the inclusion of jumps in the diffusion model represents a better alternative than not to include them.

  4. Effect of ethanol, temperature, and gas flow rate on volatile release from aqueous solutions under dynamic headspace dilution conditions.

    Tsachaki, Maroussa; Gady, Anne-Laure; Kalopesas, Michalis; Linforth, Robert S T; Athès, Violaine; Marin, Michele; Taylor, Andrew J


    On the basis of a mechanistic model, the overall and liquid mass transfer coefficients of aroma compounds were estimated during aroma release when an inert gas diluted the static headspace over simple ethanol/water solutions (ethanol concentration = 120 mL x L(-1)). Studied for a range of 17 compounds, they were both increased in the ethanol/water solution compared to the water solution, showing a better mass transfer due to the presence of ethanol, additively to partition coefficient variation. Thermal imaging results showed differences in convection of the two systems (water and ethanol/water) arguing for ethanol convection enhancement inside the liquid. The effect of ethanol in the solution on mass transfer coefficients at different temperatures was minor. On the contrary, at different headspace dilution rates, the effect of ethanol in the solution helped to maintain the volatile headspace concentration close to equilibrium concentration, when the headspace was replenished 1-3 times per minute.

  5. Determination of Nitrogen, Phosphorus, and Potassium Release Rates of Slow- and Controlled-Release Fertilizers: Single-Laboratory Validation, First Action 2015.15.

    Thiex, Nancy


    A previously validated method for the determination of nitrogen release patterns of slow- and controlled-release fertilizers (SRFs and CRFs, respectively) was submitted to the Expert Review Panel (ERP) for Fertilizers for consideration of First Action Official Method(SM) status. The ERP evaluated the single-laboratory validation results and recommended the method for First Action Official Method status and provided recommendations for achieving Final Action. The 180 day soil incubation-column leaching technique was demonstrated to be a robust and reliable method for characterizing N release patterns from SRFs and CRFs. The method was reproducible, and the results were only slightly affected by variations in environmental factors such as microbial activity, soil moisture, temperature, and texture. The release of P and K were also studied, but at fewer replications than for N. Optimization experiments on the accelerated 74 h extraction method indicated that temperature was the only factor found to substantially influence nutrient-release rates from the materials studied, and an optimized extraction profile was established as follows: 2 h at 25°C, 2 h at 50°C, 20 h at 55°C, and 50 h at 60°C.

  6. Control of Aedes albopictus larvae using time-release larvicide formulations in Louisiana.

    Nasci, R S; Wright, G B; Willis, F S


    The ability of time-release formulations of larvicides and insect growth regulators (IGRs) to provide long-term control of Aedes albopictus was investigated in the field. Larvicides used in the study were Bactimos pellets (Bacillus thuringiensis var. israelensis, active ingredient) and Abate pellets (temephos, active ingredient). The IGR Altosid (methoprene, active ingredient) was used in pellet and sand formulations. Application rates were higher than label recommendations. In a preliminary test, clay flower bowls were treated with 2 g of material. Bactimos pellets failed to provide control after 60 days. Abate pellets and the Altosid formulations provided essentially 100% control for 150 days. After 360 days in the field, the Abate pellets produced 100% larval mortality, and significant levels of control were provided by the Altosid formulations and the Bactimos pellets. In a small-scale operational trial of this technique, 1 g of Altosid pellets was applied to every container that could be located in 2 urban residential neighborhoods in Lake Charles, LA. Aedes albopictus biting populations were monitored weekly in the treated areas and in an untreated control area. Biting population densities declined significantly in treated areas compared with the control area. Results suggested that long-term control of Ae. albopictus populations can be achieved economically with one application of Altosid pellets or Abate pellets in containers.

  7. Comparison of methods for estimating motor unit firing rate time series from firing times.

    Liu, Lukai; Bonato, Paolo; Clancy, Edward A


    The central nervous system regulates recruitment and firing of motor units to modulate muscle tension. Estimation of the firing rate time series is typically performed by decomposing the electromyogram (EMG) into its constituent firing times, then lowpass filtering a constituent train of impulses. Little research has examined the performance of different estimation methods, particularly in the inevitable presence of decomposition errors. The study of electrocardiogram (ECG) and electroneurogram (ENG) firing rate time series presents a similar problem, and has applied novel simulation models and firing rate estimators. Herein, we adapted an ENG/ECG simulation model to generate realistic EMG firing times derived from known rates, and assessed various firing rate time series estimation methods. ENG/ECG-inspired rate estimation worked exceptionally well when EMG decomposition errors were absent, but degraded unacceptably with decomposition error rates of ⩾1%. Typical EMG decomposition error rates-even after expert manual review-are 3-5%. At realistic decomposition error rates, more traditional EMG smoothing approaches performed best, when optimal smoothing window durations were selected. This optimal window was often longer than the 400ms duration that is commonly used in the literature. The optimal duration decreased as the modulation frequency of firing rate increased, average firing rate increased and decomposition errors decreased. Examples of these rate estimation methods on physiologic data are also provided, demonstrating their influence on measures computed from the firing rate estimate. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. The mean time-limited crash rate of stock price

    Li, Yun-Xian; Li, Jiang-Cheng; Yang, Ai-Jun; Tang, Nian-Sheng


    In this article we investigate the occurrence of stock market crash in an economy cycle. Bayesian approach, Heston model and statistical-physical method are considered. Specifically, Heston model and an effective potential are employed to address the dynamic changes of stock price. Bayesian approach has been utilized to estimate the Heston model's unknown parameters. Statistical physical method is used to investigate the occurrence of stock market crash by calculating the mean time-limited crash rate. The real financial data from the Shanghai Composite Index is analyzed with the proposed methods. The mean time-limited crash rate of stock price is used to describe the occurrence of stock market crash in an economy cycle. The monotonous and nonmonotonous behaviors are observed in the behavior of the mean time-limited crash rate versus volatility of stock for various cross correlation coefficient between volatility and price. Also a minimum occurrence of stock market crash matching an optimal volatility is discovered.

  9. Timing of insertion of levonorgestrel-releasing intrauterine system : a randomised controlled trial

    van der Heijden, Pahh; Geomini, Pmaj; Herman, M C; Veersema, S; Bongers, M Y

    OBJECTIVE: The objective was to assess whether patient-perceived pain during the insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) depends on the timing during the menstrual cycle. DESIGN: A stratified two-armed non-inferiority randomised controlled trial. SETTING: Large

  10. Real-Time Flavor Release from French Fries Using Atmospheric Pressure Chemical Ionization-Mass Spectrometry

    Loon, W.A.M.; Linssen, J.P.H.; Boelrijk, A.E.M.; Burgering, M.J.M.; Voragen, A.G.J.


    Flavor release from French fries was measured with atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) using both assessors (in vivo) and a mouth model system (in vitro). Several volatiles measured with APCI were identified with MS-MS. The effect of frying time, salt addition, and a

  11. Religious Released Time Education: The Overlooked Open Door in Public Schools.

    Ericsson, Samuel E.; And Others

    This paper presents arguments in favor of, and legal and constitutional guidelines for, religious released time education programs as a workable counterbalance for those concerned with the trend toward secularism in public education. The guidelines are necessarily general, because laws regarding the authority of school districts to adopt released…

  12. Evaluation of in vitro release rate and in vivo absorption characteristics of four metoprolol tartrate immediate-release tablet formulations.

    Rekhi, G S; Eddington, N D; Fossler, M J; Schwartz, P; Lesko, L J; Augsburger, L L


    The purpose of this investigation was to examine the impact of formulation and process changes on dissolution and bioavailability/bioequivalency of metoprolol tartrate tablets manufactured using a high-shear granulation process. A half-factorial (2(4-1), Res IV) design was undertaken to study the selected formulation and processing variables during scale-up. Levels and ranges for excipients and processing changes studied represented level 2 or greater changes as indicated by the SUPAC-IR Guidance. Blend and tableting properties were evaluated. Changes in sodium starch glycolate and magnesium stearate levels, and the order of addition microcrystalline cellulose (intra- vs. extragranular) were significant only in affecting percent drug released (Q) in 5, 10, and 15 min. Statistical analysis of data showed no significant curvature. No interaction effects were found to be statistically significant. To examine the impact of formulation and processing variables on in vivo absorption, three batches were selected for a bioavailability study based on their dissolution profiles. Subjects received four metoprolol treatments (Lopressor, slow-, medium-, and fast-dissolving formulations) separated by 1 week according to a randomized crossover design. After an overnight fast, subjects were administered one tablet (100 mg), blood samples were collected over 24 hr and plasma samples were analyzed. The formulations were found to be bioequivalent with respect to the log Cmax and log AUC0-infinity. The results of this study suggest that: (i) bioavailability/bioequivalency studies may not be necessary for metoprolol tartrate and perhaps other class 1 drugs after level 2 type changes and (ii) in vitro dissolution tests may be used to show bioequivalence of metoprolol formulations with processing or formulation changes within the specified level 2 ranges for the equipment examined.

  13. Heart rate variability in natural time and 1/f "noise"

    Sarlis, N. V.; Skordas, E. S.; Varotsos, P. A.


    Several studies have shown that heart rate fluctuations exhibit the ubiquitous 1/f behavior which is altered in desease. Furthermore, the analysis of electrocardiograms in natural time reveals that important malfunctions in the complex system of the human heart can be identified. Here, we present a simple evolution model in natural time that exhibits the 1/fa behavior with a close to unity. The results of this model are consistent with a progressive modification of heart rate variability in healthy children and adolescents. The model results in complexity measures that separate healthy dynamics from patients as well as from sudden cardiac death individuals.

  14. Pulse wave transit time for monitoring respiration rate.

    Johansson, A; Ahlstrom, C; Lanne, T; Ask, P


    In this study, we investigate the beat-to-beat respiratory fluctuations in pulse wave transit time (PTT) and its subcomponents, the cardiac pre-ejection period (PEP) and the vessel transit time (VTT) in ten healthy subjects. The three transit times were found to fluctuate in pace with respiration. When applying a simple breath detecting algorithm, 88% of the breaths seen in a respiration air-flow reference could be detected correctly in PTT. Corresponding numbers for PEP and VTT were 76 and 81%, respectively. The performance during hypo- and hypertension was investigated by invoking blood pressure changes. In these situations, the error rates in breath detection were significantly higher. PTT can be derived from signals already present in most standard monitoring set-ups. The transit time technology thus has prospects to become an interesting alternative for respiration rate monitoring.

  15. In vitro fertility rate of 129 strain is improved by buserelin (gonadotropin-releasing hormone) administration prior to superovulation.

    Vasudevan, K; Sztein, J M


    The 129 mice are well recognized for their low fertility and it is speculated that this lack of fertility may be due to the oocyte condition. In this study we investigated superovulation regimens for the 129S1/SvImJ mouse strain to improve the oocyte quality and fertility rate of in vitro fertilization (IVF). Female mice were divided into four groups based on hormone and timing of injection. Group 1 received pregnant mare serum gonadotropin (PMSG) and 48 h later human chorionic gonadotropin (hCG); using the same dose, group 2 received hCG 52 h post-PMSG and group 3, 55 h post-PMSG. Group 4 received buserelin (gonadotropin-releasing hormone agonist [GnRH]) followed 24 h later by PMSG and then hCG 55 h post-PMSG. IVF was performed using 129S1/SvImJ oocytes and sperm; C57BL/6J sperm with 129S1/SvImJ oocytes was used as fertility control. The IVF fertility rate was 1% (Groups 1 and 2), 17% (Group 3) and 55% (Group 4) for 129 oocytes fertilized with 129 sperm. For 129 oocytes fertilized with C57BL/6J sperm, the fertility rate was 5% (Group 1), 10% (Group 2), 40% (Group 3) and 59% (Group 4). These results suggest that extending the interval time between PMSG and hCG and giving GnRH in addition to the standard PMSG and hCG treatments can improve IVF fertility rate of 129S1/SvImJ mouse strains significantly.

  16. Time-dependent release of extracellular vesicle subpopulations in tumor CABA I cells.

    Giusti, Ilaria; Di Francesco, Marianna; Cantone, Laura; D'Ascenzo, Sandra; Bollati, Valentina; Carta, Gaspare; Dolo, Vincenza


    Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various methods and techniques used to identify and isolate the specific EVs subpopulations exist. However, these methods should be further elucidated. A deep understanding of the different factors that affect the EVs release may therefore be useful for the standardization of protocols and to establish guidelines for a more adequate analysis and correct inter‑laboratory comparison. In the present study, we investigated whether composition and molecular features of EVs altered over time following a trigger stimulus. Starved CABA I cells were stimulated with FBS and conditioned medium was collected after different time intervals (30 min and 4, 8 and 18 h). The dynamic of EVs release was time-dependent, as shown by the results of scanning electron microscopy. Additionally, the time elapsed from the stimulus affected the size distribution (as highlighted by transmission electron microscopy and NanoSight assay), amount (in terms of the number of particles and protein amount) and molecular composition (CD63, HLA, Ago-2, gelatinases, and plasminogen activators) suggesting that, different EVs subpopulations were released at different time intervals following cell stimulation. Collectively, the results suggested that, parameters useful to standardize procedures for EVs isolation, including stimulation time should be considered.

  17. Time Variation of Overtopping Rates applied to WD

    Kofoed, Jens Peter

    In this investigation the results from a study on optimisation of overtopping ramps (see Kofoed & Frigaard (2000)) are used to compare with the method used by Jakobsen & Frigaard (1999) for simulating the time variation of overtopping rates in the Wave Dragon power simulation software (WDpower)....



    This paper presents a theory on premix fuel combustion at nearisosceles triangle type rate of heat release,describes the measures taken for the combustion system,points out its many theoretical advantages,and that it can solve effectively the problems of rough running,fuel consumption and exhaust emission.Two squish lip type combustion chambers are designed to match separately with multiple holes injector and conical spray type injector in order to achieve premix combustion at near isosceles triangle type rate of heat release.Experimental studies on two single cylinder diesel engines showed that premix combustion at isosceles triangle type rate of heat release resulted in longer ignition delay period,larger amount of fuel injected into cylinder during the ignition delay period,lower maximum pressure,better fuel economy,and better exhaust emission.

  19. Timing of insertion of levonorgestrel-releasing intrauterine system: a randomised controlled trial.

    van der Heijden, Pahh; Geomini, Pmaj; Herman, M C; Veersema, S; Bongers, M Y


    The objective was to assess whether patient-perceived pain during the insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) depends on the timing during the menstrual cycle. A stratified two-armed non-inferiority randomised controlled trial. Large teaching hospital in Veldhoven, the Netherlands. From October 2013 to May 2014, 60 nulliparous and 60 multiparous women were randomised. Eight women withdrew after randomisation and before insertion took place: therefore, data from 112 women were collected and analysed. Women were randomised to the groups 'during menstruation' (i.e. days 1-7 of menstruation) or 'outside menstruation' (i.e. any day of the cycle after menstruation without the presence of vaginal blood loss) in a ratio of 1 : 1. The primary outcome was pain during insertion, measured by the visual analogue scale (VAS, 0-100 mm). Second, we analysed ease of insertion, bleeding pattern, satisfaction, pregnancy, and expulsion rate. The follow-up time was 3 months. The mean VAS score for nulliparous women was 74 mm (95% confidence interval, 95% CI 67-81) in the 'during menstruation' group, compared with 66 mm (95% CI 59-74) in the 'outside menstruation' group (P = 0.14). The mean VAS score for multiparous women was 30 mm (95% CI 20-40) in the 'during menstruation group', compared with 43 mm (95% CI 32-53) in the 'outside menstruation' group (P = 0.08). There was no difference between the stratified 'during menstruation' group and the 'outside menstruation' group with regards to ease of insertion, satisfaction, bleeding pattern, and median spotting and bleeding days for the use of the LNG-IUS 3 months after insertion. As we did not find that the level of pain perceived during insertion was higher during menstruation, compared with outside menstruation, we conclude that the LNG-IUS can be inserted at any time during the menstrual cycle, especially in the case of nulliparous women. We conducted an RCT on time of insertion of

  20. Minimizing Total Completion Time For Preemptive Scheduling With Release Dates And Deadline Constraints

    He Cheng


    Full Text Available It is known that the single machine preemptive scheduling problem of minimizing total completion time with release date and deadline constraints is NP- hard. Du and Leung solved some special cases by the generalized Baker's algorithm and the generalized Smith's algorithm in O(n2 time. In this paper we give an O(n2 algorithm for the special case where the processing times and deadlines are agreeable. Moreover, for the case where the processing times and deadlines are disagreeable, we present two properties which could enable us to reduce the range of the enumeration algorithm

  1. Paper-based microfluidics with an erodible polymeric bridge giving controlled release and timed flow shutoff.

    Jahanshahi-Anbuhi, Sana; Henry, Aleah; Leung, Vincent; Sicard, Clémence; Pennings, Kevin; Pelton, Robert; Brennan, John D; Filipe, Carlos D M


    Water soluble pullulan films were formatted into paper-based microfluidic devices, serving as a controlled time shutoff valve. The utility of the valve was demonstrated by a one-step, fully automatic implementation of a complex pesticide assay requiring timed, sequential exposure of an immobilized enzyme layer to separate liquid streams. Pullulan film dissolution and the capillary wicking of aqueous solutions through the device were measured and modeled providing valve design criteria. The films dissolve mainly by surface erosion, meaning the film thickness mainly controls the shutoff time. This method can also provide time-dependent sequential release of reagents without compromising the simplicity and low cost of paper-based devices.

  2. Inverse method for estimating respiration rates from decay time series

    D. C. Forney


    Full Text Available Long-term organic matter decomposition experiments typically measure the mass lost from decaying organic matter as a function of time. These experiments can provide information about the dynamics of carbon dioxide input to the atmosphere and controls on natural respiration processes. Decay slows down with time, suggesting that organic matter is composed of components (pools with varied lability. Yet it is unclear how the appropriate rates, sizes, and number of pools vary with organic matter type, climate, and ecosystem. To better understand these relations, it is necessary to properly extract the decay rates from decomposition data. Here we present a regularized inverse method to identify an optimally-fitting distribution of decay rates associated with a decay time series. We motivate our study by first evaluating a standard, direct inversion of the data. The direct inversion identifies a discrete distribution of decay rates, where mass is concentrated in just a small number of discrete pools. It is consistent with identifying the best fitting "multi-pool" model, without prior assumption of the number of pools. However we find these multi-pool solutions are not robust to noise and are over-parametrized. We therefore introduce a method of regularized inversion, which identifies the solution which best fits the data but not the noise. This method shows that the data are described by a continuous distribution of rates which we find is well approximated by a lognormal distribution, and consistent with the idea that decomposition results from a continuum of processes at different rates. The ubiquity of the lognormal distribution suggest that decay may be simply described by just two parameters; a mean and a variance of log rates. We conclude by describing a procedure that estimates these two lognormal parameters from decay data. Matlab codes for all numerical methods and procedures are provided.

  3. Inverse method for estimating respiration rates from decay time series

    D. C. Forney


    Full Text Available Long-term organic matter decomposition experiments typically measure the mass lost from decaying organic matter as a function of time. These experiments can provide information about the dynamics of carbon dioxide input to the atmosphere and controls on natural respiration processes. Decay slows down with time, suggesting that organic matter is composed of components (pools with varied lability. Yet it is unclear how the appropriate rates, sizes, and number of pools vary with organic matter type, climate, and ecosystem. To better understand these relations, it is necessary to properly extract the decay rates from decomposition data. Here we present a regularized inverse method to identify an optimally-fitting distribution of decay rates associated with a decay time series. We motivate our study by first evaluating a standard, direct inversion of the data. The direct inversion identifies a discrete distribution of decay rates, where mass is concentrated in just a small number of discrete pools. It is consistent with identifying the best fitting "multi-pool" model, without prior assumption of the number of pools. However we find these multi-pool solutions are not robust to noise and are over-parametrized. We therefore introduce a method of regularized inversion, which identifies the solution which best fits the data but not the noise. This method shows that the data are described by a continuous distribution of rates, which we find is well approximated by a lognormal distribution, and consistent with the idea that decomposition results from a continuum of processes at different rates. The ubiquity of the lognormal distribution suggest that decay may be simply described by just two parameters: a mean and a variance of log rates. We conclude by describing a procedure that estimates these two lognormal parameters from decay data. Matlab codes for all numerical methods and procedures are provided.

  4. Angiotensin II and renal prostaglandin release in the dog. Interactions in controlling renal blood flow and glomerular filtration rate.

    Bugge, J F; Stokke, E S


    The relationship between angiotensin II and renal prostaglandins, and their interactions in controlling renal blood flow (RBF) and glomerular filtration rate (GFR) were investigated in 18 anaesthetized dogs with acutely denervated kidneys. Intrarenal angiotensin II infusion increased renal PGE2 release (veno-arterial concentration difference times renal plasma flow) from 1.7 +/- 0.9 to 9.1 +/- 0.4 and 6-keto-PGF1 alpha release from 0.1 +/- 0.1 to 5.3 +/- 2.1 pmol min-1. An angiotensin II induced reduction in RBF of 20% did not measurably change GFR whereas a 30% reduction reduced GFR by 18 +/- 8%. Blockade of prostaglandin synthesis approximately doubled the vasoconstrictory action of angiotensin II, and all reductions in RBF were accompanied by parallel reductions in GFR. When prostaglandin release was stimulated by infusion of arachidonic acid (46.8 +/- 13.3 and 15.9 +/- 5.4 pmol min-1 for PGE2, and 6-keto-PGF1 alpha, respectively), angiotensin II did not change prostaglandin release, but had similar effects on the relationship between RBF and GFR as during control. In an ureteral occlusion model with stopped glomerular filtration measurements of ureteral pressure and intrarenal venous pressure permitted calculations of afferent and efferent vascular resistances. Until RBF was reduced by 25-30% angiotensin II increased both afferent and efferent resistances almost equally, keeping the ureteral pressure constant. At greater reductions in RBF, afferent resistance increased more than the efferent leading to reductions in ureteral pressure. This pattern was not changed by blockade of prostaglandin synthesis indicating no influence of prostaglandins on the distribution of afferent and efferent vascular resistances during angiotensin II infusion. In this ureteral occlusion model glomerular effects of angiotensin II will not be detected, and it might well be that the shift from an effect predominantly on RBF to a combined effect on both RBF and GFR induced by inhibition

  5. Assessment of survival rates and reproductive success of captive bred milky stork released at Kuala Gula Bird Sanctuary, Perak

    Faiq, H.; Safie, M. Y.; Shukor, M. N.


    A release programme of captive bred Milky Storks was initiated to increase population size in the wild. Population size depends on the survival rate and breeding success of individuals in the population. Among factors that affect survival rate and breeding success are population age class and sex ratio. The main objective of this study was to estimate the survival rate of Mycteria cinerea that has been released in Kuala Gula Bird Sanctuary since 2007. The estimation of the survival rate was done across gender and age class. This study was conducted in 2012 at Kuala Gula Bird Sanctuary. The presence of M. cinerea individuals were recorded at the sanctuary and identified to background information, such as date of birth, gender and date of release. Females of M. cinerea were estimated to have a higher survival rate (30.0%) than male (16.7%). Across gender, each individual was assigned into 4 different age classes, namely less than 1 year, between 1 and 2 years, between 2 and 3 years, and more than 3 years. The survival rate of individuals less than 1 year was about 50%, between 1 and 2 years was 25%, between 2 and 3 years was 9.1%, and more than 3 years was 0%. This study was intended to facilitate future release programmeme on which gender and age class to emphasize.

  6. Simplified method for measuring the response time of scram release electromagnet in a nuclear reactor

    Patri, Sudheer, E-mail:; Mohana, M.; Kameswari, K.; Kumar, S. Suresh; Narmadha, S.; Vijayshree, R.; Meikandamurthy, C.; Venkatesan, A.; Palanisami, K.; Murthy, D. Thirugnana; Babu, B.; Prakash, V.; Rajan, K.K.


    Highlights: • An alternative method for estimating the electromagnet clutch release time. • A systematic approach to develop a computer based measuring system. • Prototype tests on the measurement system. • Accuracy of the method is ±6% and repeatability error is within 2%. - Abstract: The delay time in electromagnet clutch release during a reactor trip (scram action) is an important safety parameter, having a bearing on the plant safety during various design basis events. Generally, it is measured using current decay characteristics of electromagnet coil and its energising circuit. A simplified method of measuring the same in a Sodium cooled fast reactors (SFR) is proposed in this paper. The method utilises the position data of control rod to estimate the delay time in electromagnet clutch release. A computer based real time measurement system for measuring the electromagnet clutch delay time is developed and qualified for retrofitting in prototype fast breeder reactor. Various stages involved in the development of the system are principle demonstration, experimental verification of hardware capabilities and prototype system testing. Tests on prototype system have demonstrated the satisfactory performance of the system with intended accuracy and repeatability.

  7. Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations.

    Johnston, Michael J W; Semple, Sean C; Klimuk, Sandra K; Edwards, Katarina; Eisenhardt, Merete L; Leng, Esther C; Karlsson, Göran; Yanko, Daniel; Cullis, Pieter R


    The anti-tumor efficacy of liposomal formulations of cell cycle dependent anticancer drugs is critically dependent on the rates at which the drugs are released from the liposomes. Previous work on liposomal formulations of vincristine have shown increasing efficacy for formulations with progressively slower release rates. Recent work has also shown that liposomal formulations of vincristine with higher drug-to-lipid (D/L) ratios exhibit reduced release rates. In this work, the effects of very high D/L ratios on vincristine release rates are investigated, and the antitumor efficacy of these formulations characterized in human xenograft tumor models. It is shown that the half-times (T(1/2)) for vincristine release from egg sphingomyelin/cholesterol liposomes in vivo can be adjusted from T(1/2) = 6.1 h for a formulation with a D/L of 0.025 (wt/wt) to T(1/2) = 117 h (extrapolated) for a formulation with a D/L ratio of 0.6 (wt/wt). The increase in drug retention at the higher D/L ratios appears to be related to the presence of drug precipitates in the liposomes. Variations in the D/L ratio did not affect the circulation lifetimes of the liposomal vincristine formulations. The relationship between drug release rates and anti-tumor efficacy was evaluated using a MX-1 human mammary tumor model. It was found that the antitumor activity of the liposomal vincristine formulations increased as D/L ratio increased from 0.025 to 0.1 (wt/wt) (T(1/2) = 6.1-15.6 h respectively) but decreased at higher D/L ratios (D/L = 0.6, wt/wt) (T(1/2) = 117 h). Free vincristine exhibited the lowest activity of all formulations examined. These results demonstrate that varying the D/L ratio provides a powerful method for regulating drug release and allows the generation of liposomal formulations of vincristine with therapeutically optimized drug release rates.

  8. Sunda Shelf Seas: flushing rates and residence times

    B. Mayer


    Full Text Available The region of the Sunda Shelf has an average depth of approx. 48 m and is subject to many physical and biogeochemical processes with a strong impact from human activities. For the investigation of marine environmental water properties and quality, it is helpful to have an idea about exchange rates of water masses in the different parts of this region. Four numerical models, the global hydrodynamical model MPI-OM, the global hydrological model MPI-HM, the regional hydrodynamical model HAMSOM and a Lagrangian tracer model have been utilized to estimate the flushing rates and residence times in different seas on the Sunda Shelf. Using decadal averaged monthly transports, the commonly used flushing rate formula gives rates for the different months of approximately 40 to 70 days for the entire Sunda Shelf. For most parts of it (Malacca Strait, southern South China Sea, Java Sea, the results are similar, while for the Gulf of Thailand, the flushing rates amount to 80 to 170 days. The tracer model provides quite different but very detailed 3-D pictures with residence times of below 30 days to more than two years, depending on the location within the region, on the starting layer and on the season.

  9. Aerobic Fitness, Heart Rate Recovery and Heart Rate Recovery Time in Indian School Children.

    Fernando, Rajesh Jeniton; Ravichandran, K; Vaz, Mario


    Data on aerobic fitness and heart rate recovery in children are limited. This study was done to evaluate the relation between them in Indian school going children. Three hundred children of 7 to 10.5 years were recruited and their aerobic fitness was predicted using modified Harvard's step test (VO₂max) and 20 meter shuttle test (VO₂peak). The heart rate was monitored for 12 minutes post modified Harvard's step test. The difference between the maximum and the 1st minute HR was noted as HRR1 and the time taken to reach the resting heart rate was also recorded. VO₂max was inversely correlated with HRR1 (r = -0.64, precovery rate per unit time was 3% greater with increasing VO₂max (HR = 1.03, 95% CI:1.01 to 1.05, p = 0.013). The heart rate parameters did not show any associat with VO₂peak This study demonstrates that there is no relation between VO₂max and HRR1 after 3 minutes of modified Harvard's step test in Indian children of 7 to 10.5 years. However, aerobic fitness is a positive predictor of heart rate recovery time in this group.

  10. The 'Releasing Time to Care--the Productive Ward' programme: participants' perspectives.

    Davis, Jacqueline; Adams, John


    The aim of this study was to explore the perceptions of nursing staff concerning the implementation of the 'Releasing Time to Care - the Productive Ward' programme in a specialist cardiothoracic hospital. The 'Releasing Time to Care - the Productive Ward' programme uses the 'lean' philosophy originally developed in the Japanese motor industry to improve the efficiency of hospital wards. Its aim is to increase the proportion of time that nurses are able to spend in direct patient care. This study used a descriptive qualitative method with a sample size of four nurses and two health-care support workers. Thematic analysis of the interview transcripts was undertaken using the procedure developed by Burnard. Thematic content analysis identified five major themes: starting to implement the programme, anxiety and defensiveness, the importance of leadership and communication, challenges, and learning and personal development. Overall, the programme had a positive impact on both the wards studied. Challenges that were identified included the need to sustain momentum once the initial enthusiasm had waned. This study highlighted the importance of key transformational leadership skills at ward manager level, such as the ability to inspire nurses to approach old problems in new ways, in the implementation of the 'Releasing Time to Care - the Productive Ward' programme. © 2011 Blackwell Publishing Ltd.

  11. Effect of precipitation, sorption and stable of isotope on maximum release rates of radionuclides from engineered barrier system (EBS) in deep repository.

    Malekifarsani, A; Skachek, M A


    The basic function of the engineered barrier system (EBS) in geological disposal is to prevent or limit the release of radionuclides into the underground environment. For this purpose, the vitrified waste is contained in an overpack to isolate it from contact with groundwater for a certain initial period of time. However, it is impossible to ensure complete containment for all time. Therefore, the eventual release of nuclides must be minimized after the overpack fails (AEC, 1984. Radioactive waste processing and disposal measures; JNC, 2000a. Project to establish the scientific and technical basis for HLW disposal in Japan--first progress report-H3. Geological Environment in Japan, JNC TN1410 2000-002; JNC, 2000b. H12: project to establish the scientific and technical basis for HLW disposal in Japan--repository design and engineering technology, JNC TN1410 2000-003.). Low-permeability buffer material is installed between the overpack and the host rock to ensure that radionuclide release from the vitrified waste is limited by diffusive transport rather than advective transport in groundwater. Nuclides released from the waste form precipitate when their concentrations in the porewater result in their elemental solubility limits being exceeded. This limits the concentrations of many nuclides in the buffer and thus limits the release rates to the surrounding rock. High sorption coefficients act to delay the transport of certain nuclides during their migration through the buffer (PNC, development and management of the technical knowledge base for the geological disposal of HLW. Supporting report 2: repository engineering technology). The presence of isotopes of the same element has the effect of reducing the effective solubility of some nuclides; a lower nuclide concentration is required for precipitation to occur if the presence of any isotopes of the same element is taken into account. The calculated release rates of radionuclides from the EBS (per waste package) are

  12. Rates and mechanisms of radioactive release and retention inside a waste disposal canister - in Can Processes

    Oversby, V.M. (ed.) [and others


    the system that will not be present under long term disposal conditions. A simulation of long-term conditions can be done using uranium dioxide that contains a short-lived isotope of uranium, but this will not include the effects of fission product and higher actinide elements on the behaviour of the spent fuel. We designed a project that had as its objective to improve the scientific understanding of the processes that control release of radioactive species from spent fuel inside a disposal canister and the chemical changes in those species that might limit release of radioactivity from the canister. If the mechanisms that control dissolution of the fuel matrix, including self-irradiation effects, can be clarified, a more realistic assessment of the long-term behaviour of spent fuel under disposal conditions can be made. By removing uncertainties concerning waste form performance, a better assessment of the individual and collective role of the engineered barriers can be made. To achieve the overall objective of the project, the following scientific and technical objectives were set. 1. Measure the actual rate of matrix dissolution of uranium dioxide under oxidising and reducing conditions. 2. Measure the effect of alpha radiolysis on the dissolution rate of uranium dioxide under oxidising and reducing conditions. 3. Measure the dissolution rate of the matrix material of spent fuel and thereby determine the additional effects of beta and gamma radiation on uranium dioxide dissolution rate under oxidising and reducing conditions. 4. Measure the ability of actively corroding iron to reduce oxidised U(VI) to U(IV) when U is present as the complex ion uranyl carbonate. 5. Measure the rate of reduction of Np(V) species in the presence of actively corroding iron. 6. Calculate the expected equilibrium and steady state concentrations of U under the conditions of the experiments used for meeting objectives 1 through 3 and compare the calculated results with those measured in

  13. The surface-forming energy release rate based fracture criterion for elastic-plastic crack propagation

    Xiao, Si; Wang, He-Ling; Liu, Bin; Hwang, Keh-Chih


    The J-integral based criterion is widely used in elastic-plastic fracture mechanics. However, it is not rigorously applicable when plastic unloading appears during crack propagation. One difficulty is that the energy density with plastic unloading in the J-integral cannot be defined unambiguously. In this paper, we alternatively start from the analysis on the power balance, and propose a surface-forming energy release rate (ERR), which represents the energy available for separating the crack surfaces during the crack propagation and excludes the loading-mode-dependent plastic dissipation. Therefore the surface-forming ERR based fracture criterion has wider applicability, including elastic-plastic crack propagation problems. Several formulae are derived for calculating the surface-forming ERR. From the most concise formula, it is interesting to note that the surface-forming ERR can be computed using only the stress and deformation of the current moment, and the definition of the energy density or work density is avoided. When an infinitesimal contour is chosen, the expression can be further simplified. For any fracture behaviors, the surface-forming ERR is proven to be path-independent, and the path-independence of its constituent term, so-called Js-integral, is also investigated. The physical meanings and applicability of the proposed surface-forming ERR, traditional ERR, Js-integral and J-integral are compared and discussed. Besides, we give an interpretation of Rice paradox by comparing the cohesive fracture model and the surface-forming ERR based fracture criterion.

  14. Scanning electrochemical microscopy of metallic biomaterials: reaction rate and ion release imaging modes.

    Gilbert, J L; Smith, S M; Lautenschlager, E P


    The Scanning Electrochemical Microscope (SECM) is a nonoptical scanning microscopic instrument capable of imaging highly localized electrical currents associated with charge transfer reactions on metallic biomaterials surfaces. The SECM operates as an aqueous electrochemical cell under bipotentiostatic control with a microelectrode and sample independently biased as working electrodes. Microelectrode current and position is recorded as it is scanned very near a metallurgically polished planar sample surface. To date, the SECM has imaged metallic biomaterials surfaces in oxygen reaction rate imaging (ORRI) and ion release and deposition imaging (IRDI) modes. In ORRI, sample and microelectrode are biased at sufficiently negative potentials to reduce absorbed oxygen. As the microelectrode scans areas of active oxygen reduction, localized diffusion fields with decreased oxygen solution concentrations are encountered and resultant decrements in microelectrode current are observed. In IRDI mode the sample is positively biased and the microelectrode is negatively biased. The microelectrode detects anodic dissolution products with highest currents being observed over the most active areas. Performance of the SECM has been evaluated on Ni minigrids, gamma-1 Hg-Ag dental amalgam crystals, and sintered beads of Co-Cr-Mo alloy which represent significantly different geometries and corrosion processes to help demonstrate the potential of this instrument. The SECM is a valuable tool for imaging microelectrochemical processes on the surfaces of metallurgically polished metallic biomaterials samples and a wide variety of other surfaces of biological interest where charge transfer reactions occur. The SECM allows selective biasing of metallic biomaterials surfaces and Faradaic reactions can be selectively imaged while the surface is in the active, passive, or transpassive state.

  15. Effects of administration of gonadotropin-releasing hormone at artificial insemination on conception rates in dairy cows.

    Shephard, R W; Morton, J M; Norman, S T


    A controlled trial investigating the effect on conception of administration of 250 μg of gonadotropin-releasing hormone (GnRH) at artificial insemination (AI) in dairy cows in seasonal or split calving herds was conducted. Time of detection of estrus, body condition, extent of estrous expression, treatment, breed, age and milk production from the most recent herd test of the current lactation was recorded. Cows were tested for pregnancy with fetal aging between 35 and 135 days after AI. Sixteen herds provided 2344 spring-calved cows and 3007 inseminations. Logistic regression adjusting for clustering at herd level was used to examine the effect of treatment for first (2344) and second (579) inseminations separately. For first AI, treatment significantly improved conception rate in cows with milk protein concentrations of 3.75% or greater and for cows with milk protein concentrations between 3.00% and 3.50% and less than 40 days calved; increased conception rate from 41.2% to 53.4%. Treatment reduced conception rates in cows with milk protein concentrations of 2.75% or less. Treating only cows identified as responding positively to treatment (11% of all study cows) was estimated to increase first service conception rate in herds from 48.1% to 49.4%. There was no significant effect of treatment on conception to second AI, nor any significant interactions. These findings indicate that GnRH at AI should be limited to the sub-group cows most likely to respond. The positive effect of GnRH at AI may be mediated through improved oocyte maturation and/or improved luteal function, rather than by reducing AI-to-ovulation intervals.

  16. An analytical description of rate effects in timing RPCs

    Gonzalez-Diaz, D. [LabCaF, Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782, Santiago de Compostela (Spain)]. E-mail:; Fonte, P. [LIP, Departamento de Fisica, Universidade de Coimbra, 3004-516, Coimbra (Portugal); Instituto Superior de Engenharia de Coimbra, Rua Pedro Nunes, 3030-199, Coimbra (Portugal); Garzon, J.A. [LabCaF, Departamento de Fisica de Particulas, Universidade de Santiago de Compostela, 15782, Santiago de Compostela (Spain); Mangiarotti, A. [Physikalisches Institut der Universitaet Heidelberg, Philosophenweg 12, D-69120, Heidelberg (Germany)


    An analytical framework for describing the RPC behavior under high irradiation is proposed, including the effect of the fluctuations of the field. The description is compared with an equivalent MC and data for timing RPCs, showing good agreement. Moreover, the formalism allows to clearly identify the main variables ruling the process. By using the DC electric properties of the plates, the MC allows to reproduce the charging-up process in a dynamic situation, revealing that it takes place at the scale of the relaxation time, varying with the primary rate.

  17. The polycondensing temperature rather than time determines the degradation and drug release of poly(glycerol-sebacate) doped with 5-fluorouracil.

    Sun, Zhi-Jie; Sun, Cheng-Wu; Sun, Bo; Lu, Xi-Li; Dong, De-Li


    Poly(glycerol-sebacate) (PGS) is an elastomeric biodegradable polyester that could be used as biodegradable drug carrier. We have previously prepared PGS implants doped with 5-fluorouracil (5-FU-PGSs) and found that 5-FU-PGSs exhibited an initial burst of 5-FU release during in vitro degradation. The synthesis temperature and time are two of the most important reaction conditions for polymer synthesis. Therefore, in order to establish a controllable drug-release manner, we prepared a series of 5-FU-PGS with 2% weight of 5-FU under synthesis conditions with different polycondensing temperature and time and characterized the infrared spectrum properties, in vitro degradation and drug release. Results showed that the polycondensing temperature determined the mechanical properties, degradation and drug release of 5-FU-PGSs. With the polycondensing temperature increasing, the elastic modulus and hardness of 5-FU-PGSs increased, and the mass loss and 5-FU release rate decreased. The polycondensing time had no significant influence on the mechanical property, degradation and drug release of 5-FU-PGSs. We suggest that the polycondensing temperature is the factor to control the drug-release manner.

  18. Timing associated with oviductal sperm storage and release after artificial insemination in domestic hens

    Hemmings, N.; Birkhead, T.R.; Brillard, Jean-Pierre; Froment, Pascal; Brière, Sylvain


    Female birds store sperm in sperm storage tubules (SSTs) in the uterovaginal junction of their reproductive tract for days or weeks (depending on species) prior to fertilisation. Sperm are transported from the SSTs to the infundibulum where fertilisation occurs immediately following ovulation of each ovum. The timing of sperm release from the SSTs relative to ovulation is unknown for any bird. Here we show that, following artificial insemination of domestic fowl Gallus domesticus, sperm are n...

  19. Multiple release layer study of the intrinsic lateral etch rate of the epitaxial lift-off process

    Voncken, M.M.J.; Schermer, J.J.; Bauhuis, G.J.; Mulder, P.; Larsen, P.K.


    The lateral etch rate of AlGaAs in HF in the 'Epitaxial Lift-Off' (ELO) process consists of two parts, an intrinsic and a radius-induced part. The intrinsic part is studied with a new approach in which multiple release layers are introduced in one sample. By letting an essential ELO process paramete

  20. Attraction of agrilus planipennis fairmaire (Coleoptera: Buprestidae) to a volatile pheromone: effects of release rate, host volatile and trap placement

    Attraction of emerald ash borer, Agrilus planipennis Fairmaire, to a volatile pheromone was demonstrated in three field experiments using baited green sticky traps. A dose-response curve was generated for male A. planipennis to increasing release rates of (3Z)-dodecen-12-olide, (3Z)-lactone, in com...

  1. Release etch modeling analysis and the use of laser scanning microscopy for etch time prediction of micromachined structures

    Matamis, George; Gogoi, Bishnu P.; Monk, David J.; McNeil, Andrew; Burrows, Veronica A.


    An alternative non-destructive analysis method using laser scanning microscopy (LSM) was used to study etch release distances in MEMS pressure sensor. The LSM method eliminates samples preparation and is easy to implement in a MEMS manufacturing environment. In this study, various diaphragm structures were etched using a highly concentrated HF based solution. Experimental etch data were obtained for both SiO2 and PSG films under these various structures. Both the height and the width of the sacrificial layer port/channel had a significant effect on etch rate for both films. As expected, a non-linear etch rate was obtained for both SiO2 and PSG films. Since the HF concentration changes over time in a manufacturing bath process, careful selection of processing time is required in order to fully release MEMS structures. Future theoretical modeling with the assistance of experimental data obtained in this study is being pursued to strengthen past work done by Eaton et al, Monk et al, and Liu et al.

  2. Manual Choice Reaction Times in the Rate-Domain

    Chris eHarris


    Full Text Available Over the last 150 years, human manual reaction times (RTs have been recorded countless times. Yet, our understanding of them remains remarkably poor. RTs are highly variable with positively skewed frequency distributions, often modelled as an inverse Gaussian distribution reflecting a stochastic rise to threshold (diffusion process. However, latency distribution of saccades are very close to the reciprocal Normal, suggesting that ‘rate’ (reciprocal RT may be the more fundamental variable. We explored whether this phenomenon extends to choice manual RTs. We recorded two-alternative choice RTs from 24 subjects, each with 4 blocks of 200 trials with two task difficulties (easy vs. difficult discrimination and two instruction sets (urgent vs. accurate. We found that rate distributions were, indeed, very close to Normal, shifting to lower rates with increasing difficulty and accuracy, and for some blocks subjects they appeared to become left-truncated, but still close to Normal. Using autoregressive techniques, we found temporal sequential dependencies for lags of at least 3. We identified a transient and steady-state component in each block. Because rates were Normal, we were able to estimate autoregressive weights using the Box-Jenkins technique, and convert to a moving average model using z-transforms to show explicit dependence on stimulus input. We also found a spatial sequential dependence for the previous 3 lags depending on whether the laterality of previous trials was repeated or alternated. This was partially dissociated from temporal dependency as it only occurred in the easy tasks. We conclude that 2-alternative choice manual RT distributions are close to reciprocal Normal and not the inverse Gaussian. This is not consistent with stochastic rise to threshold models, and we propose a simple optimality model in which reward is maximized to yield to an optimal rate, and hence an optimal time to respond. We discuss how it might be

  3. Smart earthquake-resistant materials: using time-released adhesives for damping, stiffening, and deflection control

    Dry, Carolyn M.


    Preventing buildings and bridges from damage from severe dynamic loading events is a primary goal of civil infrastructure. Present designs attempt to control structural response by making the structures more massive, by increasing lateral stiffness through bracing, and by damping technology such as mass damping and base-isolation. These attempts affect portions of the governing equation: for an idealized building frame or bridge, the free vibrational behavior is described by Mu + cu + ku equals -mug(t) where m equals mass, c equals damping coefficient, k equals lateral stiffness, u equals deflection, and ug(t) equals ground acceleration. The use of adhesive released internally in a material based way of addressing the problem. The time release of low modulus adhesive chemicals would assist the damping characteristics of the structure, use of a stiffer adhesive would allow the damaged structure to regain some lateral stiffness (k) and adjustment of the set times of the adhesives would act to control the deflection. These can be thought of as potential new method of controlling vibration of behavior in case of a dynamic loading event. In past experiments, self-healing concrete matrices were shown to increase post-yield deflection and load carrying capability by the release and setting of adhesives. The results were promising in resisting damage of dynamic loads applied to frames. This indicates that self-healing concrete would be extremely valuable in civil engineering structures that were subjected to failure-inducing loads such as earthquakes.

  4. A novel nuclear magnetic resonance (NMR) imaging method for measuring the water front penetration rate in hydrophilic polymer matrix capsule plugs and its role in drug release.

    Ashraf, M; Iuorno, V L; Coffin-Beach, D; Evans, C A; Augsburger, L L


    An NMR imaging method was developed to estimate the rate of water movement in slow-release capsule matrices of pseudoephdrine HCl and hydroxypropyl cellulose (HPC). Test capsules were first placed in a USP method 2 (paddles, 50 rpm) dissolution apparatus. Each plug was removed from the dissolution medium at predetermined times, blotted dry, and placed within the magnetic field of a General Electric 400-MHz wide-bore NMR spectrometer equipped with a microimaging accessory. Images were recorded along the transverse plane of each plug. The water penetration rate was determined by comparison of the cut and weighed contour plots of the images acquired. After 1 hr, the plugs tamped to 200 N exhibited water penetration to the center, while only 45% of the drug was released. The percentage dry matrix was fitted to the Jost equation to obtain a diffusion coefficient of 4.15 x 10(-6) cm2/sec. NMR imaging is set forth as an important and practicable technique to investigate drug formulations. In the HPC matrix system of this study, the NMR imaging results convincingly revealed the rate of hydration front penetration not to be a rate-limiting step in the drug release process.

  5. Fast Timing for High-Rate Environments with Micromegas

    Papaevangelou, Thomas; Ferrer-Ribas, Esther; Giomataris, Ioannis; Godinot, Cyprien; Gonzalez Diaz, Diego; Gustavsson, Thomas; Kebbiri, Mariam; Oliveri, Eraldo; Resnati, Filippo; Ropelewski, Leszek; Tsiledakis, Georgios; Veenhof, Rob; White, Sebastian


    The current state of the art in fast timing resolution for existing experiments is of the order of 100 ps on the time of arrival of both charged particles and electromagnetic showers. Current R&D on charged particle timing is approaching the level of 10 ps but is not primarily directed at sustained performance at high rates and under high radiation (as would be needed for HL-LHC pileup mitigation). We demonstrate a Micromegas based solution to reach this level of performance. The Micromegas acts as a photomultiplier coupled to a Cerenkov-radiator front window, which produces sufficient UV photons to convert the ~100 ps single-photoelectron jitter into a timing response of the order of 10-20 ps per incident charged particle. A prototype has been built in order to demonstrate this performance. The first laboratory tests with a pico-second laser have shown a time resolution of the order of 27 ps for ~50 primary photoelectrons, using a bulk Micromegas readout.




    Full Text Available To obtain inflation forecasts is an important economic issue. The more accurate forecasts we get implies the more precise decisions we make. The central Bank reports inflation rates in certain periods of every year. In this reports the results of inflation expectation survey are presented. In this study we use an approach in which relationship is determined by artificial neural network in high order fuzzy time series model. Time series of consumer price index is estimated by both the artificial neural network based method and some fuzzy approaches which is common in the literature. The results are compared to the results of inflation expectation survey analysis conducted by Central Bank of the Republic of Turkey in the aspect of forecasts accuracy.

  7. The average rate of change for continuous time models.

    Kelley, Ken


    The average rate of change (ARC) is a concept that has been misunderstood in the applied longitudinal data analysis literature, where the slope from the straight-line change model is often thought of as though it were the ARC. The present article clarifies the concept of ARC and shows unequivocally the mathematical definition and meaning of ARC when measurement is continuous across time. It is shown that the slope from the straight-line change model generally is not equal to the ARC. General equations are presented for two measures of discrepancy when the slope from the straight-line change model is used to estimate the ARC in the case of continuous time for any model linear in its parameters, and for three useful models nonlinear in their parameters.

  8. Formulation and evaluation of press coated tablets of salbutamol sulphate for time controlled release

    M D Wasimul Hasan


    Full Text Available The objective of the present study was to formulate and evaluate a press coated pulsatile drug delivery system of salbutamol sulphate in order to attain a time controlled release for treatment of nocturnal asthma. The core was prepared by direct compression, while press coating technique was used in coating the outer layer there by preparing a press coated tablet. The immediate release core formulations comprised of salbutamol sulphate and disintegrants like crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with the drug. The outer coat formulations were prepared using a hydrophilic (HPMC and hydrophobic (EC polymer of similar viscosity. The polymers were reviewed individually for their influence on lag time further obtaining the lag time using polymer combinations were assessed by employing central composite design. All the preliminary trials were evaluated for various post compression parameters along with the dissolution study that was performed using USP paddle method at 50 rpm in 0.1 N HCl and phosphate buffer pH 6.8. The formulation containing 300 mg of EC N50 and 75-100 mg of HPMC E50 may be regarded as the minimum quantity required in outer press coat so as to attain a predetermined lag time of 6 h.

  9. Electrospun Polymer Blend Nanofibers for Tunable Drug Delivery: The Role of Transformative Phase Separation on Controlling the Release Rate.

    Tipduangta, Pratchaya; Belton, Peter; Fábián, László; Wang, Li Ying; Tang, Huiru; Eddleston, Mark; Qi, Sheng


    Electrospun fibrous materials have a wide range of biomedical applications, many of them involving the use of polymers as matrices for incorporation of therapeutic agents. The use of polymer blends improves the tuneability of the physicochemical and mechanical properties of the drug loaded fibers. This also benefits the development of controlled drug release formulations, for which the release rate can be modified by altering the ratio of the polymers in the blend. However, to realize these benefits, a clear understanding of the phase behavior of the processed polymer blend is essential. This study reports an in depth investigation of the impact of the electrospinning process on the phase separation of a model partially miscible polymer blend, PVP K90 and HPMCAS, in comparison to other conventional solvent evaporation based processes including film casting and spin coating. The nanoscale stretching and ultrafast solvent removal of electrospinning lead to an enhanced apparent miscibility between the polymers, with the same blends showing micronscale phase separation when processed using film casting and spin coating. Nanoscale phase separation in electrospun blend fibers was confirmed in the dry state. Rapid, layered, macroscale phase separation of the two polymers occurred during the wetting of the fibers. This led to a biphasic drug release profile from the fibers, with a burst release from PVP-rich phases and a slower, more continuous release from HPMCAS-rich phases. It was noted that the model drug, paracetamol, had more favorable partitioning into the PVP-rich phase, which is likely to be a result of greater hydrogen bonding between PVP and paracetamol. This led to higher drug contents in the PVP-rich phases than the HPMCAS-rich phases. By alternating the proportions of the PVP and HPMCAS, the drug release rate can be modulated.

  10. Estimating Divergence Times and Substitution Rates in Rhizobia.

    Chriki-Adeeb, Rim; Chriki, Ali


    Accurate estimation of divergence times of soil bacteria that form nitrogen-fixing associations with most leguminous plants is challenging because of a limited fossil record and complexities associated with molecular clocks and phylogenetic diversity of root nodule bacteria, collectively called rhizobia. To overcome the lack of fossil record in bacteria, divergence times of host legumes were used to calibrate molecular clocks and perform phylogenetic analyses in rhizobia. The 16S rRNA gene and intergenic spacer region remain among the favored molecular markers to reconstruct the timescale of rhizobia. We evaluate the performance of the random local clock model and the classical uncorrelated lognormal relaxed clock model, in combination with four tree models (coalescent constant size, birth-death, birth-death incomplete sampling, and Yule processes) on rhizobial divergence time estimates. Bayes factor tests based on the marginal likelihoods estimated from the stepping-stone sampling analyses strongly favored the random local clock model in combination with Yule process. Our results on the divergence time estimation from 16S rRNA gene and intergenic spacer region sequences are compatible with age estimates based on the conserved core genes but significantly older than those obtained from symbiotic genes, such as nodIJ genes. This difference may be due to the accelerated evolutionary rates of symbiotic genes compared to those of other genomic regions not directly implicated in nodulation processes.

  11. Connecting Galaxies, Halos, and Star Formation Rates Across Cosmic Time

    Conroy, Charlie; Wechsler, Risa H.


    A simple, observationally-motivated model is presented for understanding how halo masses, galaxy stellar masses, and star formation rates are related, and how these relations evolve with time. The relation between halo mass and galaxy stellar mass is determined by matching the observed spatial abundance of galaxies to the expected spatial abundance of halos at multiple epochs--i.e. more massive galaxies are assigned to more massive halos at each epoch. This 'abundance matching' technique has been shown previously to reproduce the observed luminosity- and scale-dependence of galaxy clustering over a range of epochs. Halos at different epochs are connected by halo mass accretion histories estimated from N-body simulations. The halo-galaxy connection at fixed epochs in conjunction with the connection between halos across time provides a connection between observed galaxies across time. With approximations for the impact of merging and accretion on the growth of galaxies, one can then directly infer the star formation histories of galaxies as a function of stellar and halo mass. This model is tuned to match both the observed evolution of the stellar mass function and the normalization of the observed star formation rate--stellar mass relation to z {approx} 1. The data demands, for example, that the star formation rate density is dominated by galaxies with M{sub star} {approx} 10{sup 10.0-10.5} M{sub {circle_dot}} from 0 < z < 1, and that such galaxies over these epochs reside in halos with M{sub vir} {approx} 10{sup 11.5-12.5} M{sub {circle_dot}}. The star formation rate--halo mass relation is approximately Gaussian over the range 0 < z < 1 with a mildly evolving mean and normalization. This model is then used to shed light on a number of issues, including (1) a clarification of 'downsizing', (2) the lack of a sharp characteristic halo mass at which star formation is truncated, and (3) the dominance of star formation over merging to the stellar

  12. Rate of Iceland Sea acidification from time series measurements

    J. Olafsson


    Full Text Available The Iceland Sea is one part of the Nordic Seas. Cold Arctic Water prevails there and the deep water is an important source of North Atlantic Deep Water. We have evaluated time series observations of measured pCO2 and total CO2 concentration from discrete seawater samples during 1985–2008 for changes in response to increasing atmospheric carbon dioxide. The surface pH in winter decreases 0.0024 yr−1, which is 50% faster than those at two subtropical time series stations, BATS and ESTOC. In the deep water regime (>1500 m, the rate of pH decline is ¼ of that observed in surface waters. The surface calcium carbonate saturation states (Ω are about 1.5 for aragonite and 2.5 for calcite, and are about ½ those for subtropical waters. During the period 1985–2008, the degree of saturation (Ω decreased at a rate of 0.0072 yr−1 for aragonite and 0.012 yr−1 for calcite. The aragonite saturation horizon is currently at 1750 m and rising at 4 m yr−1. Based on local hypsography, each year causes 800 km2 of sea floor, previously bathed in saturated waters, to be exposed to undersaturation conditions.

  13. The quenching time scale and quenching rate of galaxies

    Lian, Jianhui; Zhang, Kai; Kong, Xu


    The average star formation rate (SFR) in galaxies has been declining since redshift of 2. A fraction of galaxies quench and become quiescent. We constrain two key properties of the quenching process: the quenching time scale and the quenching rate among galaxies. We achieve this by analyzing the galaxy number density profile in NUV-u color space and the distribution in NUV-u v.s. u-i color-color diagram with a simple toy-model framework. We focus on galaxies in three mass bins between 10 to 10 and 10 to 10.6 solar mass. In the NUV-u v.s. u-i color-color diagram, the red u-i galaxies exhibit a different slope from the slope traced by the star-forming galaxies. This angled distribution and the number density profile of galaxies in NUV-u space strongly suggest that the decline of the SFR in galaxies has to accelerate before they turn quiescent. We model this color-color distribution with a two-phase exponential decline star formation history. The models with an e-folding time in the second phase (the quenching p...

  14. Real-time electrochemical recording of dopamine release under optogenetic stimulation.

    Wen-Tai Chiu

    Full Text Available Dopaminergic PC12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. Optogenetic stimulation of channelrhodopsin-2 provides high spatial and temporal precision for selective stimulation as a powerful neuromodulation tool for neuroscience studies. The aim of this study is to measure dopamine release from dopaminergic PC12 cells under optogenetic stimulation using electrochemical recording of self-assembled monolayers modified microelectrode with amperometric measurement in real time. The activation of PC12 cells under various optogenetic stimulation schemes are characterized by measuring single-cell Ca(2+ imaging. After 10 seconds of optogenetic stimulation, the evoked intracellular Ca(2+ level and dopamine current of channelrhodopsin-2-transfected PC12 cells were 1.6- and 3.5-fold higher than those of the control cells. The optogenetic stimulation effects on Ca(2+ influx and dopamine release were 81% and 63% inhibition by using a Ca(2+ channel antagonist Nifedipine. The results indicate that optogenetic stimulation can evoke voltage-gated Ca(2+ channel-dependent dopamine exocytosis from PC12 cells in a cell specific, temporally precise and dose-dependent manner. This proposed dopamine recording system can be developed to be a good cell model for dopamine regulation and drug screening in vitro, or dopaminergic cell implantation therapy in vivo using optogenetic stimulation in a precise and convenient way.

  15. Real-time electrochemical recording of dopamine release under optogenetic stimulation.

    Chiu, Wen-Tai; Lin, Che-Ming; Tsai, Tien-Chun; Wu, Chun-Wei; Tsai, Ching-Lin; Lin, Sheng-Hsiang; Chen, Jia-Jin Jason


    Dopaminergic PC12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. Optogenetic stimulation of channelrhodopsin-2 provides high spatial and temporal precision for selective stimulation as a powerful neuromodulation tool for neuroscience studies. The aim of this study is to measure dopamine release from dopaminergic PC12 cells under optogenetic stimulation using electrochemical recording of self-assembled monolayers modified microelectrode with amperometric measurement in real time. The activation of PC12 cells under various optogenetic stimulation schemes are characterized by measuring single-cell Ca(2+) imaging. After 10 seconds of optogenetic stimulation, the evoked intracellular Ca(2+) level and dopamine current of channelrhodopsin-2-transfected PC12 cells were 1.6- and 3.5-fold higher than those of the control cells. The optogenetic stimulation effects on Ca(2+) influx and dopamine release were 81% and 63% inhibition by using a Ca(2+) channel antagonist Nifedipine. The results indicate that optogenetic stimulation can evoke voltage-gated Ca(2+) channel-dependent dopamine exocytosis from PC12 cells in a cell specific, temporally precise and dose-dependent manner. This proposed dopamine recording system can be developed to be a good cell model for dopamine regulation and drug screening in vitro, or dopaminergic cell implantation therapy in vivo using optogenetic stimulation in a precise and convenient way.

  16. Estimation of peacock bass (Cichla spp.) mortality rate during catch-release fishing employing different post-capture procedures.

    Barroco, L S A; Freitas, C E C; Lima, Á C


    The effect of catch-and-release fishing on the survival of peacock bass (Cichla spp.) was evaluated by comparing two types of artificial bait (jig and shallow-diver plugs) and two types of post-catch confinement. Two experiments were conducted during the periods January-February and October-November 2012 in the Unini River, a right-bank tributary of the Negro River. In total, 191 peacock bass were captured. Both groups of fish were subjected to experimental confinement (collective and individual) for three days. Additionally, 11 fish were tagged with radio transmitters for telemetry monitoring. Mortality rate was estimated as the percentage of dead individuals for each type of bait and confinement. For peacock bass caught with jig baits, mortality was zero. The corresponding figure for shallow-diver bait was 1.66% for fish in collective containment, 18.18% for fish monitored by telemetry and 0% for individuals confined individually. Our results show low post-release mortality rates for peacock bass. Furthermore, neither the type of confinement nor the type of bait had a statistically significant influence on mortality rates. While future studies could include other factors in the analysis, our results show that catch-and-release fishing results in low mortality rates.

  17. Development of time and pH dependent controlled release colon specific delivery of tinidazole


    Full Text Available Purpose: Tinidazole is used in treatment of amoebiasis and other protozoal infections in doses of 2.0 g/ day (60 mg/kg for three days. In the present paper, controlled release formulation of tinidazole was developed with an objective to achieve colon specific drug delivery with reduced frequency of dosing, to minimize gastric side effects and thus to increase patient compliance. Methods: Matrix systems of tinidazole (500 mg were prepared by using swellable and pH dependent polymers like hydroxypropyl methylcellulose (HPMC K4M and K15M and eudragit (eudragit L-100 and S-100. Prepared tablets were enteric coated in order to overcome variability in gastric emptying time and delay in the release, to reduce gastric side effects and to provide prolonged localized action in colon. Process of manufacture was optimized during the scale up studies. Bioavailability study (using parallel group design was carried of on conventional marketed, developed uncoated and enteric coated tablets in healthy human volunteers. Results: Bioavailability study showed that greater portion of tinidazole was released in the large intestine and drug level in plasma was above 4 mg/mL in blood for 24 hours. Conclusion: From the results of this study it appears that, the proposed single enteric coated tinidazole (500 mg tablet per day could be used in place of 3-4 doses of 500 mg tinidazole conventional tablet with better control of drug release for targeted drug delivery. In addition developed colon-specific drug delivery system (CDDS was relatively inexpensive and easy to manufacture using conventional pharmaceutical coating technique.

  18. Anthocyanin Incorporated Dental Copolymer: Bacterial Growth Inhibition, Mechanical Properties, and Compound Release Rates and Stability by 1H NMR

    Halyna Hrynash


    Full Text Available Objective. To evaluate bacterial growth inhibition, mechanical properties, and compound release rate and stability of copolymers incorporated with anthocyanin (ACY; Vaccinium macrocarpon. Methods. Resin samples were prepared (Bis-GMA/TEGDMA at 70/30 mol% and incorporated with 2 w/w% of either ACY or chlorhexidine (CHX, except for the control group. Samples were individually immersed in a bacterial culture (Streptococcus mutans for 24 h. Cell viability (n=3 was assessed by counting the number of colony forming units on replica agar plates. Flexural strength (FS and elastic modulus (E were tested on a universal testing machine (n=8. Compound release and chemical stability were evaluated by UV spectrophotometry and 1H NMR (n=3. Data were analyzed by one-way ANOVA and Tukey’s test (α = 0.05. Results. Both compounds inhibited S. mutans growth, with CHX being most effective (P<0.05. Control resin had the lowest FS and E values, followed by ACY and CHX, with statistical difference between control and CHX groups for both mechanical properties (P<0.05. The 24 h compound release rates were ACY: 1.33 μg/mL and CHX: 1.92 μg/mL. 1H NMR spectra suggests that both compounds remained stable after being released in water. Conclusion. The present findings indicate that anthocyanins might be used as a natural antibacterial agent in resin based materials.

  19. Real-Time Chemical Measurements of Dopamine Release in the Brain

    Roberts, James G.; Lugo-Morales, Leyda Z.; Loziuk, Philip L.; Sombers, Leslie A.


    Rapid changes in extracellular dopamine concentrations in freely moving or anesthetized rats can be detected using fast-scan cyclic voltammetry (FSCV). Background-subtracted FSCV is a real-time electrochemical technique that can monitor neurochemical transmission in the brain on a subsecond timescale, while providing chemical information on the analyte. Also, this voltammetric approach allows for the investigation of the kinetics of release and uptake of molecules in the brain. This chapter describes, completely, how to make these measurements and the properties of FSCV that make it uniquely suitable for performing chemical measurements of dopaminergic neurotransmission in vivo. PMID:23296789

  20. Micromagnetic Cancer Cell Immobilization and Release for Real-Time Single Cell Analysis

    Jaiswal, Devina; Rad, Armin Tahmasbi; Nieh, Mu-Ping; Claffey, Kevin P.; Hoshino, Kazunori


    Understanding the interaction of live cells with macromolecules is crucial for designing efficient therapies. Considering the functional heterogeneity found in cancer cells, real-time single cell analysis is necessary to characterize responses. In this study, we have designed and fabricated a microfluidic channel with patterned micromagnets which can temporarily immobilize the cells during analysis and release them after measurements. The microchannel is composed of plain coverslip top and bottom panels to facilitate easy microscopic observation and undisturbed application of analytes to the cells. Cells labeled with functionalized magnetic beads were immobilized in the device with an efficiency of 90.8±3.6%. Since the micromagnets are made of soft magnetic material (Ni), they released cells when external magnetic field was turned off from the channel. This allows the reuse of the channel for a new sample. As a model drug analysis, the immobilized breast cancer cells (MCF7) were exposed to fluorescent lipid nanoparticles and association and dissociation were measured through fluorescence analysis. Two concentrations of nanoparticles, 0.06 μg/ml and 0.08 μg/ml were tested and time lapse images were recorded and analyzed. The microfluidic device was able to provide a microenvironment for sample analysis, making it an efficient platform for real-time analysis.

  1. Real-time measurement of volatile chemicals released by bed bugs during mating activities.

    Ole Kilpinen

    Full Text Available In recent years, bed bug (Hemiptera: Cimicidae problems have increased dramatically in many parts of the world, leading to a renewed interest in their chemical ecology. Most studies of bed bug semiochemicals have been based on the collection of volatiles over a period of time followed by chemical analysis. Here we present for the first time, a combination of proton transfer reaction mass spectrometry and video analysis for real-time measurement of semiochemicals emitted by isolated groups of bed bugs during specific behavioural activities. The most distinct peaks in the proton transfer reaction mass spectrometry recordings were always observed close to the termination of mating attempts, corresponding to the defensive emissions that bed bugs have been suspected to exploit for prevention of unwanted copulations. The main components of these emissions were (E-2-hexenal and (E-2-octenal recorded in ratios between 1:3 and 3:1. In the current study, the quantity varied over 1000 fold for both of the compounds with up to 40 µg total release in a single emission. Males also emit defensive compounds due to homosexual copulation attempts by other males, and no significant differences were observed in the ratio or the amount of the two components released from males or females. In summary, this study has demonstrated that combining proton-transfer-reaction mass spectrometry with video analysis can provide detailed information about semiochemicals emitted during specific behavioural activities.

  2. Real-time measurement of volatile chemicals released by bed bugs during mating activities.

    Kilpinen, Ole; Liu, Dezhao; Adamsen, Anders Peter S


    In recent years, bed bug (Hemiptera: Cimicidae) problems have increased dramatically in many parts of the world, leading to a renewed interest in their chemical ecology. Most studies of bed bug semiochemicals have been based on the collection of volatiles over a period of time followed by chemical analysis. Here we present for the first time, a combination of proton transfer reaction mass spectrometry and video analysis for real-time measurement of semiochemicals emitted by isolated groups of bed bugs during specific behavioural activities. The most distinct peaks in the proton transfer reaction mass spectrometry recordings were always observed close to the termination of mating attempts, corresponding to the defensive emissions that bed bugs have been suspected to exploit for prevention of unwanted copulations. The main components of these emissions were (E)-2-hexenal and (E)-2-octenal recorded in ratios between 1:3 and 3:1. In the current study, the quantity varied over 1000 fold for both of the compounds with up to 40 µg total release in a single emission. Males also emit defensive compounds due to homosexual copulation attempts by other males, and no significant differences were observed in the ratio or the amount of the two components released from males or females. In summary, this study has demonstrated that combining proton-transfer-reaction mass spectrometry with video analysis can provide detailed information about semiochemicals emitted during specific behavioural activities.

  3. From Spin Noise to Systematics: Stochastic Processes in the First International Pulsar Timing Array Data Release

    Lentati, L; Coles, W A; Verbiest, J P W; van Haasteren, R; Ellis, J A; Caballero, R N; Manchester, R N; Arzoumanian, Z; Babak, S; Bassa, C G; Bhat, N D R; Brem, P; Burgay, M; Burke-Spolaor, S; Champion, D; Chatterjee, S; Cognard, I; Cordes, J M; Dai, S; Demorest, P; Desvignes, G; Dolch, T; Ferdman, R D; Fonseca, E; Gair, J R; Gonzalez, M E; Graikou, E; Guillemot, L; Hessels, J W T; Hobbs, G; Janssen, G H; Jones, G; Karuppusamy, R; Keith, M; Kerr, M; Kramer, M; Lam, M T; Lasky, P D; Lassus, A; Lazarus, P; Lazio, T J W; Lee, K J; Levin, L; Liu, K; Lynch, R S; Madison, D R; McKee, J; McLaughlin, M; McWilliams, S T; Mingarelli, C M F; Nice, D J; Osłowski, S; Pennucci, T T; Perera, B B P; Perrodin, D; Petiteau, A; Possenti, A; Ransom, S M; Reardon, D; Rosado, P A; Sanidas, S A; Sesana, A; Shaifullah, G; Siemens, X; Smits, R; Stairs, I; Stappers, B; Stinebring, D R; Stovall, K; Swiggum, J; Taylor, S R; Theureau, G; Tiburzi, C; Toomey, L; Vallisneri, M; van Straten, W; Vecchio, A; Wang, J -B; Wang, Y; You, X P; Zhu, W W; Zhu, X -J


    We analyse the stochastic properties of the 49 pulsars that comprise the first International Pulsar Timing Array (IPTA) data release. We use Bayesian methodology, performing model selection to determine the optimal description of the stochastic signals present in each pulsar. In addition to spin-noise and dispersion-measure (DM) variations, these models can include timing noise unique to a single observing system, or frequency band. We show the improved radio-frequency coverage and presence of overlapping data from different observing systems in the IPTA data set enables us to separate both system and band-dependent effects with much greater efficacy than in the individual PTA data sets. For example, we show that PSR J1643$-$1224 has, in addition to DM variations, significant band-dependent noise that is coherent between PTAs which we interpret as coming from time-variable scattering or refraction in the ionised interstellar medium. Failing to model these different contributions appropriately can dramatically...

  4. Organic carbon decomposition rates controlled by water retention time across inland waters

    Catalán, Núria; Marcé, Rafael; Kothawala, Dolly N.; Tranvik, Lars. J.


    The loss of organic carbon during passage through the continuum of inland waters from soils to the sea is a critical component of the global carbon cycle. Yet, the amount of organic carbon mineralized and released to the atmosphere during its transport remains an open question, hampered by the absence of a common predictor of organic carbon decay rates. Here we analyse a compilation of existing field and laboratory measurements of organic carbon decay rates and water residence times across a wide range of aquatic ecosystems and climates. We find a negative relationship between the rate of organic carbon decay and water retention time across systems, entailing a decrease in organic carbon reactivity along the continuum of inland waters. We find that the half-life of organic carbon is short in inland waters (2.5 +/- 4.7 yr) compared to terrestrial soils and marine ecosystems, highlighting that freshwaters are hotspots of organic carbon degradation. Finally, we evaluate the response of organic carbon decay rates to projected changes in runoff. We calculate that regions projected to become drier or wetter as the global climate warms will experience changes in organic carbon decay rates of up to about 10%, which illustrates the influence of hydrological variability on the inland waters carbon cycle.

  5. Controllable deterioration rate for time-dependent demand and time-varying holding cost

    Mishra Vinod Kumar


    Full Text Available In this paper, we develop an inventory model for non-instantaneous deteriorating items under the consideration of the facts: deterioration rate can be controlled by using the preservation technology (PT during deteriorating period, and holding cost and demand rate both are linear function of time, which was treated as constant in most of the deteriorating inventory models. So in this paper, we developed a deterministic inventory model for non-instantaneous deteriorating items in which both demand rate and holding cost are a linear function of time, deterioration rate is constant, backlogging rate is variable and depend on the length of the next replenishment, shortages are allowed and partially backlogged. The model is solved analytically by minimizing the total cost of the inventory system. The model can be applied to optimizing the total inventory cost of non-instantaneous deteriorating items inventory for the business enterprises, where the preservation technology is used to control the deterioration rate, and demand & holding cost both are a linear function of time.

  6. Connecting Galaxies, Halos, and Star Formation Rates Across Cosmic Time

    Conroy, Charlie


    A simple, observationally-motivated model is presented for understanding how halo masses, galaxy stellar masses, and star formation rates are related, and how these relations evolve with time. The relation between halo mass and galaxy stellar mass is determined by matching the observed spatial abundance of galaxies to the expected spatial abundance of halos at multiple epochs -- i.e. more massive galaxies are assigned to more massive halos at each epoch. Halos at different epochs are connected by halo mass accretion histories estimated from N-body simulations. The halo--galaxy connection at fixed epochs in conjunction with the connection between halos across time provides a connection between observed galaxies across time. With approximations for the impact of merging and accretion on the growth of galaxies, one can then directly infer the star formation histories of galaxies as a function of stellar and halo mass. This model is tuned to match both the observed evolution of the stellar mass function and the n...

  7. Real time imaging of live cell ATP leaking or release events by chemiluminescence microscopy

    Zhang, Yun [Iowa State Univ., Ames, IA (United States)


    The purpose of this research was to expand the chemiluminescence microscopy applications in live bacterial/mammalian cell imaging and to improve the detection sensitivity for ATP leaking or release events. We first demonstrated that chemiluminescence (CL) imaging can be used to interrogate single bacterial cells. While using a luminometer allows detecting ATP from cell lysate extracted from at least 10 bacterial cells, all previous cell CL detection never reached this sensitivity of single bacteria level. We approached this goal with a different strategy from before: instead of breaking bacterial cell membrane and trying to capture the transiently diluted ATP with the firefly luciferase CL assay, we introduced the firefly luciferase enzyme into bacteria using the modern genetic techniques and placed the CL reaction substrate D-luciferin outside the cells. By damaging the cell membrane with various antibacterial drugs including antibiotics such as Penicillins and bacteriophages, the D-luciferin molecules diffused inside the cell and initiated the reaction that produces CL light. As firefly luciferases are large protein molecules which are retained within the cells before the total rupture and intracellular ATP concentration is high at the millmolar level, the CL reaction of firefly luciferase, ATP and D-luciferin can be kept for a relatively long time within the cells acting as a reaction container to generate enough photons for detection by the extremely sensitive intensified charge coupled device (ICCD) camera. The result was inspiring as various single bacterium lysis and leakage events were monitored with 10-s temporal resolution movies. We also found a new way of enhancing diffusion D-luciferin into cells by dehydrating the bacteria. Then we started with this novel single bacterial CL imaging technique, and applied it for quantifying gene expression levels from individual bacterial cells. Previous published result in single cell gene expression quantification

  8. A theoretical approach to evaluate the release rate of acetaminophen from erosive wax matrix dosage forms.

    Agata, Yasuyoshi; Iwao, Yasunori; Shiino, Kai; Miyagishima, Atsuo; Itai, Shigeru


    To predict drug dissolution and understand the mechanisms of drug release from wax matrix dosage forms containing glyceryl monostearate (GM; a wax base), aminoalkyl methacrylate copolymer E (AMCE; a pH-dependent functional polymer), and acetaminophen (APAP; a model drug), we tried to derive a novel mathematical model with respect to erosion and diffusion theory. Our model exhibited good agreement with the whole set of experimentally obtained values pertaining to APAP release at pH 4.0 and pH 6.5. In addition, this model revealed that the eroding speed of wax matrices was strongly influenced by the loading content of AMCE, but not that of APAP, and that the diffusion coefficient increased as APAP loading decreased and AMCE loading increased, thus directly defining the physicochemical properties of erosion and diffusion. Therefore, this model might prove a useful equation for the precise prediction of dissolution and for understanding the mechanisms of drug release from wax matrix dosage forms. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. 77 FR 15969 - Waybill Data Released in Three-Benchmark Rail Rate Proceedings


    ... compares the R/VC ratios (i.e., percentage markups over variable cost) of particular current movements... compare current rates against older rates or current costs against historical costs, but rather R/VC... its simplified rail rate guidelines, creating a Simplified Stand-Alone Cost approach for...

  10. Tritium release from neutron irradiated beryllium: Kinetics, long-time annealing and effect or crack formation

    Scaffidi-Argentina, F.; Werle, H. [Forschungszentrum Karlsruhe, (Germany)


    Since beryllium is considered as one of the best neutron multiplier materials in the blanket of the next generation fusion reactors, several studies have been started to evaluate its behaviour under irradiation during both operating and accidental conditions. Based on safety considerations, tritium produced in beryllium during neutron irradiation represents one important issue, therefore it is necessary to investigate tritium transport processes by using a comprehensive mathematical model and comparing its predictions with well characterized experimental tests. Because of the difficulties in extrapolating the short-time tritium release tests to a longer time scale, also long-time annealing experiments with beryllium samples from the SIBELIUS irradiation. have been carried out at the Forschungszentrum Karlsruhe. Samples were annealed up to 12 months at temperatures up to 650{degrees}C. The inventory after annealing was determined by heating the samples up to 1050{degrees}C with a He+0.1 vo1% H{sub 2} purge gas. Furthermore, in order to investigate the likely effects of cracks formation eventually causing a faster tritium release from beryllium, the behaviour of samples irradiated at low temperature (40-50{degrees}C) but up to very high fast neutron fluences (0.8-3.9{center_dot}10{sup 22} cm{sup -2}, E{sub n}{ge}1 MeV) in the BR2 reactor has been investigated. Tritium was released by heating the beryllium samples up to 1050{degrees}C and purging them with He+0.1 vo1% H{sub 2}. Tritium release from high-irradiated beryllium samples showed a much faster kinetics than from the low-irradiated ones, probably because of crack formation caused by thermal stresses in the brittle material and/or by helium bubbles migration. The obtained experimental data have been compared with predictions of the code ANFIBE with the goal to better understand the physical mechanisms governing tritium behaviour in beryllium and to assess the prediction capabilities of the code.

  11. Fuzzy economic production quantity model with time dependent demand rate

    Susanta Kumar Indrajitsingha


    Full Text Available Background: In this paper, an economic production quantity model is considered under a fuzzy environment. Both the demand cost and holding cost are considered using fuzzy pentagonal numbers. The Signed Distance Method is used to defuzzify the total cost function. Methods: The results obtained by these methods are compared with the help of a numerical example. Sensitivity analysis is also carried out to explore the effect of changes in the values of some of the system parameters. Results and conclusions: The fuzzy EPQ model with time dependent demand rate was presented together with the possible implementation. The behavior of changes in parameters was analyzed. The possible extension of the implementation of this method was presented.

  12. Interpreting the Dependence of Mutation Rates on Age and Time.

    Ziyue Gao


    Full Text Available Mutations can originate from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that arise between replication cycles and are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing a framework for understanding how mutation rates depend on sex, age, and cell division rate. We show that the accrual of mutations should track cell divisions not only when mutations are replicative in origin but also when they are non-replicative and repaired efficiently. One implication is that observations from diverse fields that to date have been interpreted as pointing to a replicative origin of most mutations could instead reflect the accumulation of mutations arising from endogenous reactions or exogenous mutagens. We further find that only mutations that arise from inefficiently repaired lesions will accrue according to absolute time; thus, unless life history traits co-vary, the phylogenetic "molecular clock" should not be expected to run steadily across species.

  13. A relation between screening masses and real-time rates

    Brandt, B.B. [Institute for Theoretical Physics, University of Regensburg,93040 Regensburg (Germany); Francis, A. [PRISMA Cluster of Excellence, Institute for Nuclear Physics,Helmholtz Institute Mainz, Johannes Gutenberg University Mainz,55099 Mainz (Germany); Laine, M. [Institute for Theoretical Physics, Albert Einstein Center, University of Bern,Sidlerstrasse 5, 3012 Bern (Switzerland); Meyer, H.B. [PRISMA Cluster of Excellence, Institute for Nuclear Physics,Helmholtz Institute Mainz, Johannes Gutenberg University Mainz,55099 Mainz (Germany)


    Thermal screening masses related to the conserved vector current are determined for the case that the current carries a non-zero Matsubara frequency, both in a weak-coupling approach and through lattice QCD. We point out that such screening masses are sensitive to the same infrared physics as light-cone real-time rates. In particular, on the perturbative side, the inhomogeneous Schrödinger equation determining screening correlators is shown to have the same general form as the equation implementing LPM resummation for the soft-dilepton and photon production rates from a hot QCD plasma. The static potential appearing in the equation is identical to that whose soft part has been determined up to NLO and on the lattice in the context of jet quenching. Numerical results based on this potential suggest that screening masses overshoot the free results (multiples of 2πT) more strongly than at zero Matsubara frequency. Four-dimensional lattice simulations in two-flavour QCD at temperatures of 250 and 340 MeV confirm the non-static screening masses at the 10% level. Overall our results lend support to studies of jet quenching based on the same potential at T≳250 MeV.

  14. Amount, Timing, and Rate of Global Contraction on Mercury

    Klimczak, C.; Byrne, P. K.; Banks, M. E.; Solomon, S. C.


    Mercury's surface hosts a large number of thrust-fault-related landforms that primarily accommodated global contraction driven by interior cooling. The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft returned a wealth of data that allow for a detailed characterization of the amount and timing of that contraction. In particular, mapping of thrust-fault-related landforms shows that the planet experienced a radius decrease of 5.1±2 km since the end of heavy bombardment. Cross-cutting relationships of thrust faults with impact craters of different degradation stages indicate that global contraction operated throughout much of Mercury's past, with the earliest evidence for faulting dating from near the time of cessation of widespread plains volcanism. An assessment of the brittle strength of Mercury's lithosphere indicates that 0.4±0.1 to 2.1±0.4 km of radius change is necessary for stresses to be sufficiently large to overcome the frictional resistance to sliding on pre-existing fractures and faults. These values not only increase estimates for the overall amount of global contraction but also imply that this process was initiated before any evidence of shortening in the geologic record was manifest as brittle deformation. Together, these observations and results have implications for the rate at which global contraction operated through Mercury's geologic history. Higher initial strain rates are required if the radial contraction prior to the initiation of thrust faulting was ~2.1 km, and are possible but not required if the radial contraction accommodated prior to the onset of thrust faulting was ~0.4 km. These findings incorporate an aspect of global contraction not previously considered, as well as a contribution to radius change beyond that inferable from mapping. This approach is applicable to inferences on global contraction from tectonic mapping, and constraints on thermal histories, for any world dominated by secular

  15. Towards more physiological manipulations of hormones in field studies: comparing the release dynamics of three kinds of testosterone implants, silastic tubing, time-release pellets and beeswax.

    Quispe, Rene; Trappschuh, Monika; Gahr, Manfred; Goymann, Wolfgang


    Hormone manipulations are of increasing interest in the areas of physiological ecology and evolution, because hormones are mediators of complex phenotypic changes. Often, however, hormone manipulations in field settings follow the approaches that have been used in classical endocrinology, potentially using supra-physiological doses. To answer ecological and evolutionary questions, it may be important to manipulate hormones within their physiological range. We compare the release dynamics of three kinds of implants, silastic tubing, time-release pellets, and beeswax pellets, each containing 3mg of testosterone. These implants were placed into female Japanese quail, and plasma levels of testosterone measured over a period of 30 days. Testosterone in silastic tubing led to supraphysiological levels. Also, testosterone concentrations were highly variable between individuals. Time-release pellets led to levels of testosterone that were slightly supraphysiological during the first days. Over the period of 30 days, however, testosterone concentrations were more consistent. Beeswax implants led to a physiological increase in testosterone and a relatively constant release. The study demonstrated that hormone implants in 10mm silastic tubing led to a supraphysiological peak in female quail. Thus, the use of similar-sized or even larger silastic implants in males or in other smaller vertebrates needs careful assessment. Time-release pellets and beeswax implants provide a more controlled release and degrade within the body. Thus, it is not necessary to recapture the animal to remove the implant. We propose beeswax implants as an appropriate procedure to manipulate testosterone levels within the physiological range. Hence, such implants may be an effective alternative for field studies.

  16. Cortisol release, heart rate and heart rate variability in the horse and its rider: different responses to training and performance.

    von Lewinski, Mareike; Biau, Sophie; Erber, Regina; Ille, Natascha; Aurich, Jörg; Faure, Jean-Michel; Möstl, Erich; Aurich, Christine


    Although some information exists on the stress response of horses in equestrian sports, the horse-rider team is much less well understood. In this study, salivary cortisol concentrations, heart rate (HR) and heart rate variability (HRV), SDRR (standard deviation of beat-to-beat interval) and RMSSD (root mean square of successive beat-to-beat intervals) were analysed in horses and their riders (n=6 each) at a public performance and an identical rehearsal that was not open to the public. Cortisol concentrations increased in both horses and riders (Phorses and riders increased during the rehearsal and the public performance (Priders than in their horses during the public performance (from 91 ± 10 to 150 ± 15 beats/min) compared to the rehearsal (from 94 ± 10 to 118 ± 12 beats/min). The SDRR decreased significantly during the equestrian tasks in riders (Phorses. The RMSSD decreased in horses and riders (Priders was more pronounced (Priders than it did in their horses.

  17. Calculation of the inventory and near-field release rates of radioactivity from neutron-activated metal parts discharged from the high flux isotope reactor and emplaced in solid waste storage area 6 at Oak Ridge National Laboratory

    Kelmers, A.D.; Hightower, J.R.


    Emplacement of contaminated reactor components involves disposal in lined and unlined auger holes in soil above the water table. The radionuclide inventory of disposed components was calculated. Information on the composition and weight of the components, as well as reasonable assumptions for the neutron flux fueling use, the time of neutron exposure, and radioactive decay after discharge, were employed in the inventory calculation. Near-field release rates of /sup 152/Eu, /sup 154/Eu, and /sup 155/Eu from control plates and cylinders were calculated for 50 years after emplacement. Release rates of the europium isotopes were uncertain. Two release-rate-limiting models were considered and a range of reasonable values were assumed for the time-to-failure of the auger-hole linear and aluminum cladding and europium solubility in SWSA-6 groundwater. The bounding europium radionuclide near-field release rates peaked at about 1.3 Ci/year total for /sup 152,154,155/Eu in 1987 for the lower bound, and at about 420 Ci/year in 1992 for the upper bound. The near-field release rates of /sup 55/Fe, /sup 59/Ni, /sup 60/Co, and /sup 63/Ni from stainless steel and cobalt alloy components, as well as of /sup 10/Be, /sup 41/Ca, and /sup 55/Fe from beryllium reflectors, were calculated for the next 100 years, assuming bulk waste corrosion was the release-rate-limiting step. Under the most conservative assumptions for the reflectors, the current (1986) total radionuclide release rate was calculated to be about 1.2 x 10/sup -4/ Ci/year, decreasing by 1992 to a steady release of about 1.5 x 10/sup -5/ Ci/year due primarily to /sup 41/Ca. 50 refs., 13 figs., 8 tabs.

  18. Sleep apnea detection using time-delayed heart rate variability.

    Nano, Marina-Marinela; Xi Long; Werth, Jan; Aarts, Ronald M; Heusdens, Richard


    Sleep apnea is a sleep disorder distinguished by repetitive absence of breathing. Compared with the traditional expensive and cumbersome methods, sleep apnea diagnosis or screening with physiological information that can be easily acquired is needed. This paper describes algorithms using heart rate variability (HRV) to automatically detect sleep apneas as long as it can be easily acquired with unobtrusive sensors. Because the changes in cardiac activity are usually hysteretic than the presence of apneas with a few minutes, we propose to use the delayed HRV features to identify the episodes with sleep apneic events. This is expected to help improve the apnea detection performance. Experiments were conducted with a data set of 23 sleep apnea patients using support vector machine (SVM) classifiers and cross validations. Results show that using eleven HRV features with a time delay of 1.5 minutes rather than the features without time delay for SA detection, the overall accuracy increased from 74.9% to 76.2% and the Cohen's Kappa coefficient increased from 0.49 to 0.52. Further, an accuracy of 94.5% and a Kappa of 0.89 were achieved when applying subject-specific classifiers.

  19. Preparation of Sinomenine Hydrochloride Sustained Release Tablet and determination of the release rate%盐酸青藤碱缓释片的制备及其释放度测定

    洪怡; 刘亚杰; 胡建峰


    Objective To prepare the Sinomenine Hydrochloride Sustained Release Tablet. Methods The prescription was selected by orthogonal design and the investigation index was the effect of EC, MCC and lactose to the release rate. The release rate and the release behavior were studied. Results The release rate of sustained release tablet fitted the first release eqution and the release rate for 12 h was more than 75%. Conclusion The prescription is reasonable, the technology is simple and the release effect is good.%目的 制备盐酸青藤碱缓释片.方法 采用正交设计法,考察乙基纤维素、微晶纤维素、乳糖对缓释片溶出度的影响,进行处方筛选,对最佳处方进行溶出度测定及释放行为的拟合.结果 缓释片的释放行为符合一级释放方程,12 h释放度大于75%.结论 该缓释片处方合理,工艺简单,缓释效果好.

  20. Steady State Flammable Gas Release Rate Calculation and Lower Flammability Level Evaluation for Hanford Tank Waste

    HU, T.A.


    This work is to assess the steady-state flammability level at normal and off-normal ventilation conditions in the tank dome space for 177 double-shell and single-shell tanks at Hanford. Hydrogen generation rate was calculated for 177 tanks using rate equation model developed recently.


    HU, T.A.


    Assess the steady-state flammability level at normal and off-normal ventilation conditions. The hydrogen generation rate was calculated for 177 tanks using the rate equation model. Flammability calculations based on hydrogen, ammonia, and methane were performed for 177 tanks for various scenarios.


    HU TA


    Assess the steady-state flammability level at normal and off-normal ventilation conditions. The hydrogen generation rate was calculated for 177 tanks using the rate equation model. Flammability calculations based on hydrogen, ammonia, and methane were performed for 177 tanks for various scenarios.

  3. Determining Ca2+-sensor binding time and its variability in evoked neurotransmitter release.

    Yoon, Ava Chomee; Kathpalia, Vinnie; D'Silva, Sahana; Cimenser, Aylin; Hua, Shao-Ying


    The speed and reliability of neuronal reactions are important factors for proper functioning of the nervous system. To understand how organisms use protein molecules to carry out very fast biological actions, we quantified single-molecule reaction time and its variability in synaptic transmission. From the synaptic delay of crayfish neuromuscular synapses the time for a few Ca(2+) ions to bind with their sensors in evoked neurotransmitter release was estimated. In standard crayfish saline at room temperature, the average Ca(2+) binding time was 0.12 ms for the first evoked quanta. At elevated extracellular Ca(2+) concentrations this binding time reached a limit due to saturation of Ca(2+) influx. Analysis of the synaptic delay variance at various Ca(2+) concentrations revealed that the variability of the Ca(2+)-sensor binding time is the major source of the temporal variability of synaptic transmission, and that the Ca(2+)-independent molecular reactions after Ca(2+) influx were less stochastic. The results provide insights into how organisms maximize reaction speed and reliability.

  4. Evaluation of Plantago major L. seed mucilage as a rate controlling matrix for sustained release of propranolol hydrochloride.

    Saeedi, Majid; Morteza-Semnani, Katayoun; Sagheb-Doust, Mehdi


    Polysaccharide mucilage derived from the seeds of Plantago major L. (family Plantaginaceae) was investigated for use in matrix formulations containing propranolol hydrochloride. HPMC K4M and tragacanth were used as standards for comparison. The hardness, tensile strength, and friability of tablets increased as the concentration of mucilage increased, indicating good compactibility of mucilage powders. The rate of release of propranolol hydrochloride from P. major mucilage matrices was mainly controlled by the drug/mucilage ratio. Formulations containing P. major mucilage were found to exhibit a release rate comparable to HPMC containing matrices at a lower drug/polymer ratio (drug/HPMC 2:1). These results demonstrated that P. major mucilage is a better release retardant compared to tragacanth at an equivalent content. The results of kinetic analysis showed that in F3 (containing 1:2 drug/mucilage) the highest correlation coefficient was achieved with the zero order model. The swelling and erosion studies revealed that as the proportion of mucilage in tablets was increased, there was a corresponding increase in percent swelling and a decrease in percent erosion of tablets. The DSC and FT-IR studies showed that no formation of complex between the drug and mucilage or changes in crystallinity of the drug had occurred.

  5. Timing associated with oviductal sperm storage and release after artificial insemination in domestic hens.

    Hemmings, N; Birkhead, T R; Brillard, J P; Froment, P; Briere, S


    Female birds store sperm in sperm storage tubules (SSTs) in the uterovaginal junction of their reproductive tract for days or weeks (depending on species) before fertilization. Sperm are transported from the SSTs to the infundibulum where fertilization occurs immediately after ovulation of each ovum. The timing of sperm release from the SSTs relative to ovulation is unknown for any bird. Here, we show that, after artificial insemination of domestic fowl Gallus domesticus, sperm are not accepted into any region of the oviduct before sexual maturity. Once hens reach maturity, there is a temporal shift in the distribution of sperm throughout the oviduct. Sperm are first accepted into and accumulate in the SSTs 6 to 8 days before ovulation but are at this point significantly less numerous in the infundibulum. From 1 to 6 days before ovulation, approximately 10-fold more sperm (235 × 10(3) sperm) populate the infundibulum than at 6 to 8 days before ovulation (26 × 10(3) sperm; P < 0.001). Our results suggest that the mechanisms underlying sperm acceptance and release in the oviduct are under fine temporal control, most likely mediated by female hormones.

  6. Waiting time before release increases the motivation to home in homing pigeons (Columba livia)

    Dell'Ariccia, Gaia; Costantini, David; Dell'Omo, Giacomo; Lipp, Hans-Peter


    .... Quite often, the last pigeons disappear straightforward from the release site. The question is whether this reflects improved orientation because of prolonged exposure to the release place or whether it reflects increased homing motivation...

  7. Evidence That the Pi Release Event Is the Rate-Limiting Step in the Nitrogenase Catalytic Cycle.

    Yang, Zhi-Yong; Ledbetter, Rhesa; Shaw, Sudipta; Pence, Natasha; Tokmina-Lukaszewska, Monika; Eilers, Brian; Guo, Qingjuan; Pokhrel, Nilisha; Cash, Valerie L; Dean, Dennis R; Antony, Edwin; Bothner, Brian; Peters, John W; Seefeldt, Lance C


    Nitrogenase reduction of dinitrogen (N2) to ammonia (NH3) involves a sequence of events that occur upon the transient association of the reduced Fe protein containing two ATP molecules with the MoFe protein that includes electron transfer, ATP hydrolysis, Pi release, and dissociation of the oxidized, ADP-containing Fe protein from the reduced MoFe protein. Numerous kinetic studies using the nonphysiological electron donor dithionite have suggested that the rate-limiting step in this reaction cycle is the dissociation of the Fe protein from the MoFe protein. Here, we have established the rate constants for each of the key steps in the catalytic cycle using the physiological reductant flavodoxin protein in its hydroquinone state. The findings indicate that with this reductant, the rate-limiting step in the reaction cycle is not protein-protein dissociation or reduction of the oxidized Fe protein, but rather events associated with the Pi release step. Further, it is demonstrated that (i) Fe protein transfers only one electron to MoFe protein in each Fe protein cycle coupled with hydrolysis of two ATP molecules, (ii) the oxidized Fe protein is not reduced when bound to MoFe protein, and (iii) the Fe protein interacts with flavodoxin using the same binding interface that is used with the MoFe protein. These findings allow a revision of the rate-limiting step in the nitrogenase Fe protein cycle.

  8. Removal rate and releases of polybrominated diphenyl ethers in two wastewater treatment plants, Korea

    Lee, Hyo Jin; Kim, Gi Beum


    Wastewater treatment plants (WWTPs) play an important role in minimizing the release of many pollutants into the environment. Nineteen congeners in two WWTPs in Korea were determined to investigate the occurrence and fate of polybrominated diphenyl ethers (PBDEs) during wastewater treatment processes. The concentration of total PBDEs was 69.6 and 183 ng/L in influent, which declined to 1.59 and 2.34 ng/L in the final effluent, respectively (Tongyeong and Jinhae WWTPs). PBDEs were found to exist mostly in the particulate phase of wastewater, which rendered sedimentation efficient for the removal of PBDEs. BDE-209 was the predominant congener in the influent and sludge. Most of the PBDEs entering the WWTPs presumably ended up in the sludge, with WWTP in Korea.

  9. A real-time positron monitor for the estimation of stack effluent releases from PET medical cyclotron facilities.

    Mukherjee, Bhaskar


    Large activities of short-lived positron emitting radiopharmaceuticals are routinely manufactured by modern Medical Cyclotron facilities for positron emission tomography (PET) applications. During radiochemical processing, a substantial fraction of the volatile positron emitting radiopharmaceuticals are released into the atmosphere. An inexpensive, fast response positron detector using a simple positron-annihilation chamber has been developed for real-time assessment of the stack release of positron emitting effluents at the Australian National Medical Cyclotron. The positron detector was calibrated by using a 3.0 ml (1.50 MBq) aliquot of 18FDG and interfaced to an industrial standard datalogger for the real-time acquisition of stack release data.

  10. Reaction rate estimation of controlled-release antifouling paint binders: Rosin-based systems

    Meseguer Yebra, Diego; Kiil, Søren; Dam-Johansen, Kim


    at product optimisation and innovation (e.g. incorporation of natural active agents). This study seeks to attain scientifically founded knowledge of the reaction mechanisms and the rate of reaction with sea water of a Zn-carboxylate of a synthetic rosin compound. The kinetic expression attained can be used...... have shown that mathematical coating models based on a fundamental knowledge of the underlying mechanisms of A/F paints is a promising tool for accelerated product testing at different operational conditions of a sailing ship or a paint rotor. Such models can also be used for generation of ideas aiming...... rather than pointing at a certain diffusion control in the reaction rate experiments. The reverse reaction is found not to affect the hydrolysis rate within the pores, of antifouling paints significantly. It is concluded, from the reaction mechanism proposed, that the observed partial exchange of Zn2...

  11. Solar Energetic-Particle Release Times in Historic Ground-Level Events

    Reames, Donald V.


    Ground-level events (GLEs) are large solar energetic-particle events with sufficiently hard spectra for GeV protons to be detected by neutron monitors at ground level. For each of 30 well-observed historic GLEs from four solar cycles, extending back to 1973, I have plotted onset times versus velocity-1 for particles observed on the IMP-7 and 8, ISEE-3, Wind, and GOES spacecraft and by neutron monitors. A linear fit on such a plot for each GLE determines the initial solar particle release (SPR) time, as the intercept, and the magnetic path length traversed, as the slope, of the fitted line. Magnetic path lengths and SPR times are well determined by the fits and cannot be used as adjustable parameters to make particle and photon emission times coincide. SPR times follow the onsets of shock-induced type II radio bursts and the coronal height of the coronal mass ejection (CME)-driven shock at SPR time can be determined for GLEs spanning an interval of solar longitude of ~140 deg. For a given GLE, all particle species and energies diverge from a single SPR point at a given coronal height and footpoint longitude of the field line to the Earth. These heights tend to increase with longitudinal distance away from the source, a pattern expected for shock acceleration. Acceleration for magnetically well-connected large GLEs begins at ~2 solar radii, in contrast to non-GLEs that have been found to be strongly associated with shocks above ~3 solar radii. The higher densities and magnetic field strengths at lower altitudes may be responsible for the acceleration of higher-energy particles in GLEs, while those GLEs that begin above 3R S may compensate by having higher shock speeds. These results support the joint dependence of maximum particle energy on magnetic field strength, injected particle density, and shock speed, all predicted theoretically.

  12. Star Formation Rate Indicators in Wide-Field Infrared Survey Preliminary Release

    Fei Shi; Xu Kong; James Wicker; Yang Chen; Zi-Qiang Gong; Dong-Xin Fan


    With the goal of investigating the degree at which the MIR luminosity in the Wide-field Infrared Survey Explorer (WISE) traces the SFR, we analyse 3.4, 4.6, 12 and 22 m data in a sample of ∼ 140,000 star-forming galaxies or star-forming regions covering a wide range in metallicity 7.66 < 12 + \\log (O/H) < 9.46, with redshift < 0.4. These star-forming galaxies or star-forming regions are selected by matching the WISE Preliminary Release Catalog with the star-forming galaxy Catalog in SDSS DR8 provided by JHU/MPA. We study the relationship between the luminosity at 3.4, 4.6, 12 and 22 m from WISE and H luminosity in SDSS DR8. From these comparisons, we derive reference SFR indicators for use in our analysis. Linear correlations between SFR and the 3.4, 4.6, 12 and 22 m luminosity are found, and calibrations of SFRs based on L(3.4), L(4.6), L(12) and L(22) are proposed. The calibrations hold for galaxies with verified spectral observations. The dispersion in the relation between 3.4, 4.6, 12 and 22 m luminosity and SFR relates to the galaxy’s properties, such as 4000 Å break and galaxy color.

  13. CDC Releases Report on 30-Year Low in Youth Homicide Rates

    ... is one too many. Comprehensive approaches that include evidence-based prevention strategies are essential to eliminate homicide as ... to 24 years, and 28.8 for non-Hispanic black youth. The annual rate ... school-based programs that build students’ communications skills to solve ...

  14. Growth rates and post-release survival of captive neonate timber rattlesnakes Crotalus horridus

    Richard N. Conner; D. Craig Rudolph; Daniel Saenz; Richard R. Schaefer; Shirley J. Burgdorf


    The need for conservation and management of rare species is becoming increasingly important as wildlife species and their habitat continue to decline. Translocation of wild captured adults to augment and reintroduce populations has been successfully used for some endangered avian species (see Carrie et al. 1999; Rudolph et al. 1992). In general, success rates for...

  15. Determination of the releasing rate of Compound Doxycycline Sustained-release Gel in vivo%复方多西环素缓释凝胶的体内释放度测定

    程凤峡; 张海芳; 杨玉鹏; 田华; 刘勇


    Objective To observe the releasing rate in vivo of Compound Doxycycline Sustained-release Gel. Methods 11 patients were enrolled in and 26 teeth were divided into Experimental group and Control group .After one week of initial treatment ,the periodontal pockets of defective teeth in Control group were injected Compound Doxycycline Gel and those in experimental group were injected Compound Doxycycline Sustained-release Gel.Gingival crevicular fluid ( GCF ) samples were collected every day by filter strip after administering medicine ,and the concentration of doxycycline in GCF was tested by HPLC.Results The concentration of doxycycline in GCF decreased to 6.82μg/ml on the third day of treatment with Compound Doxycycline Gel;while the concentration of doxycycline in GCF could still maintain at 60 .46μg/ml on the seventh day after the treatment with Compound Doxycycline Sustained-release Gel.Conclusion Compound Doxycycline Sustained-release gel can be slowly released in periodontal pocket , and the doxycycline can be maintained at an effective concentration within a long time.%目的:观察复方多西环素缓释凝胶的体内缓释性能。方法将11名患者的26颗患牙随机分为实验组和对照组,于基础治疗1周后,分别在牙周袋内置入复方多西环素缓释凝胶和复方多西环素凝胶,并于置药后每天定时用滤纸条法采集龈沟液样本,高效液相色谱法测定龈沟液内多西环素的浓度。结果复方多西环素凝胶在用药后第3天,龈沟液内多西环素浓度已降至6.82μg/ml;复方多西环素缓释凝胶在用药7 d后龈沟液内多西环素浓度仍可达到60.46μg/ml。结论复方多西环素缓释凝胶在牙周袋内可缓慢释放,较长时间维持有效浓度。

  16. A semimechanistic model of the time-course of release of PTH into plasma following administration of the calcilytic JTT-305/MK-5442 in humans.

    Cabal, Antonio; Mehta, Khamir; Ross, David S; Shrestha, Rajiv P; Comisar, Wendy; Denker, Andrew; Pai, Sudhakar M; Ishikawa, Tomohiro


    JTT-305/MK-5442 is a calcium-sensing receptor (CaSR) allosteric antagonist being investigated for the treatment of osteoporosis. JTT-305/MK-5442 binds to CaSRs, thus preventing receptor activation by Ca(2+) . In the parathyroid gland, this results in the release of parathyroid hormone (PTH). Sharp spikes in PTH secretion followed by rapid returns to baseline are associated with bone formation, whereas sustained elevation in PTH is associated with bone resorption. We have developed a semimechanistic, nonpopulation model of the time-course relationship between JTT-305/MK-5442 and whole plasma PTH concentrations to describe both the secretion of PTH and the kinetics of its return to baseline levels. We obtained mean concentration data for JTT-305/MK-5442 and whole PTH from a multiple dose study in U.S. postmenopausal women at doses of 5, 10, 15, and 20 mg. We hypothesized that PTH is released from two separate sources: a reservoir that is released rapidly (within minutes) in response to reduction in Ca(2+) binding, and a second source released more slowly following hours of reduced Ca(2+) binding. We modeled the release rates of these reservoirs as maximum pharmacologic effect (Emax ) functions of JTT-305/MK-5442 concentration. Our model describes both the dose-dependence of PTH time of occurrence for maximum drug concentration (Tmax ) and maximum concentration of drug (Cmax ), and the extent and duration of the observed nonmonotonic return of PTH to baseline levels following JTT-305/MK-5442 administration.

  17. Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration

    Kousaku Kawashima


    Full Text Available Purpose. Few reports have compared the clinical efficacy of a pH-dependent release formulation of mesalazine (pH-5-ASA with a time-dependent release formulation (time-5-ASA. We examined whether pH-5-ASA is effective for active ulcerative colitis (UC in patients resistant to time-5-ASA. Methods. We retrospectively and prospectively analyzed the efficacy of pH-5-ASA in mildly to moderately active UC patients in whom time-5-ASA did not successfully induce or maintain remission. The clinical efficacy of pH-5-ASA was assessed by clinical activity index (CAI before and after switching from time-5-ASA. In addition, the efficacy of pH-5-ASA on mucosal healing (MH was evaluated in a prospective manner by measuring fecal calprotectin concentration. Results. Thirty patients were analyzed in a retrospective manner. CAI was significantly reduced at both 4 and 8 weeks after switching to pH-5-ASA. In the prospective study (n=14, administration of pH-5-ASA also significantly reduced CAI scores at 4 and 8 weeks in these patients who were resistant to time-5-ASA. In addition, fecal calprotectin concentration was significantly decreased along with improvement in CAI after switching to pH-5-ASA. Conclusions. Our results suggest that pH-5-ASA has clinical efficacy for mildly to moderately active patients with UC in whom time-5-ASA did not successfully induce or maintain remission.

  18. Tracks FAQs: How Can I Tell If Asthma Hospitalization Rates In My Area Are Changing Over Time?


    In this podcast, CDC Tracking experts discuss asthma hospitalization rates and how you can tell if they've changed in your area over time. Do you have a question for our Tracking experts? Please e-mail questions to  Created: 6/7/2011 by National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Environmental Health Tracking Branch.   Date Released: 6/7/2011.

  19. Estimations of direct release rate of 137Cs and 90Sr to the ocean from the Fukushima Dai-ichi Nuclear Power Plant for five-and-a-half years

    Tsumune, Daisuke; Aoyama, Michio; Tsubono, Takaki; Misumi, Kazuhiro; Tateda, Yutaka


    A series of accidents at the Fukushima Dai-ichi Nuclear Power Plant (1F NPP) following the earthquake and tsunami of 11 March 2011 resulted in the release of radioactive materials to the ocean by two major pathways, direct release from the accident site and atmospheric deposition. Additional release pathways by river input and runoff from 1F NPP site with precipitation and were also effective for coastal zone in the specific periods before starting direct release on March 26 2011. Direct release from 1F NPP site is dominant one year after the accident. We estimated the direct release rate of 137Cs and 90Sr for more than five-and-a-half years after the accident by the Regional Ocean Model System (ROMS). Direct release rate of 137Cs were estimated for five-and-a-half years after the accident by comparing simulated results and measured activities adjacent to the 1F NPP site(at 5,6 discharge and south discharge). Directly release rate of 137Cs was estimated to be the order of magnitude of 1014 Bq/day and decreased exponentially with time to be the order of magnitude of 109 Bq/day by the end of September 2016. Estimated direct release rate have exponentially reduced with constant rate since November 2011. Apparent half-life of direct release rate was estimated to be 346 days. The estimated total amounts of directly released 137Cs was 3.7±0.7 PBq for five and a half years. Simulated 137Cs activities attributable to direct release were in good agreement with observed activities, a result that implies the estimated direct release rate was reasonable. Simulated 137Cs activity affected off coast in the Fukushima prefecture. We used the measured 137Cs activities by the Tokyo Electric Power Company (TEPCO) for the estimation of direct release. The sea water samples were corrected from the coast. The averaged 137Cs activities from November 2013 to June 2016 were 391 and 383 Bq/m3 at 5,6 discharge and south discharge, respectively. The averaged 137Cs activities measured by the

  20. The biowaiver extension for BCS class III drugs: the effect of dissolution rate on the bioequivalence of BCS class III immediate-release drugs predicted by computer simulation.

    Tsume, Yasuhiro; Amidon, Gordon L


    The Biopharmaceutical Classification System (BCS) guidance issued by the FDA allows waivers for in vivo bioavailability and bioequivalence studies for immediate-release (IR) solid oral dosage forms only for BCS class I drugs. However, a number of drugs within BCS class III have been proposed to be eligible for biowaivers. The World Health Organization (WHO) has shortened the requisite dissolution time of BCS class III drugs on their Essential Medicine List (EML) from 30 to 15 min for extended biowaivers; however, the impact of the shorter dissolution time on AUC(0-inf) and C(max) is unknown. The objectives of this investigation were to assess the ability of gastrointestinal simulation software to predict the oral absorption of the BCS class I drugs propranolol and metoprolol and the BCS class III drugs cimetidine, atenolol, and amoxicillin, and to perform in silico bioequivalence studies to assess the feasibility of extending biowaivers to BCS class III drugs. The drug absorption from the gastrointestinal tract was predicted using physicochemical and pharmacokinetic properties of test drugs provided by GastroPlus (version 6.0). Virtual trials with a 200 mL dose volume at different drug release rates (T(85%) = 15 to 180 min) were performed to predict the oral absorption (C(max) and AUC(0-inf)) of the above drugs. Both BCS class I drugs satisfied bioequivalence with regard to the release rates up to 120 min. The results with BCS class III drugs demonstrated bioequivalence using the prolonged release rate, T(85%) = 45 or 60 min, indicating that the dissolution standard for bioequivalence is dependent on the intestinal membrane permeability and permeability profile throughout the gastrointestinal tract. The results of GastroPlus simulations indicate that the dissolution rate of BCS class III drugs could be prolonged to the point where dissolution, rather than permeability, would control the overall absorption. For BCS class III drugs with intestinal absorption patterns

  1. Atmospheric plume progression as a function of time and distance from the release point for radioactive isotopes

    Eslinger, Paul W.; Bowyer, Ted W.; Cameron, Ian M.; Hayes, James C.; Miley, Harry S.


    The International Monitoring System contains up to 80 stations around the world that have aerosol and xenon monitoring systems designed to detect releases of radioactive materials to the atmosphere from nuclear tests. A rule of thumb description of plume concentration and duration versus time and distance from the release point is useful when designing and deploying new sample collection systems. This paper uses plume development from atmospheric transport modeling to provide a power-law rule describing atmospheric dilution factors as a function of distance from the release point.

  2. Solar Energetic Particle Event of 2005 January 20: Release Times and Possible Sources

    Gui-Ming Le; Yu-Hua Tang; Yan-Ben Han


    Based on cosmic ray data obtained by neutron monitors at the Earth's surface, and data on near-relativistic electrons measured by the WIND satellite, as well as on solar X-ray and radio burst data, the solar energetic particle (SEP) event of 2005 January 20 is studied. The results show that this event is a mixed event where the flare is dominant in the acceleration of the SEPs, the interplanetary shock accelerates mainly solar protons with energies below 130 MeV, while the relativistic protons are only accelerated by the solar flare. The interplanetary shock had an obvious acceleration effect on relativistic electrons with energies greater than 2 MeV. It was found that the solar release time for the relativistic protons was about 06:41 UT, while that for the near-relativistic electrons was about 06:39 UT. The latter turned out to be about 2 min later than the onset time of the interplanetary type Ⅲ burst.

  3. Persistence in us interest rates: Is it stable over time?

    Caporale, GM; Gil-Alana, LA


    This paper analyses persistence in US interest rates. It focuses on the Federal Funds effective rate, whose degree of persistence is modelled using fractional integration, monthly from July 1954 through March 2008. The full-sample estimates of the fractional differencing parameter appear to be very sensitive to the choice of the I(0) error term; specifically, the order of integration is strictly above 1 if the errors are uncorrelated, whilst it is strictly below 1 with autocorrelated disturba...

  4. Diffusive spatio-temporal noise in a first-passage time model for intracellular calcium release

    Flegg, Mark B.


    The intracellular release of calcium from the endoplasmic reticulum is controlled by ion channels. The resulting calcium signals exhibit a rich spatio-temporal signature, which originates at least partly from microscopic fluctuations. While stochasticity in the gating transition of ion channels has been incorporated into many models, the distribution of calcium is usually described by deterministic reaction-diffusion equations. Here we test the validity of the latter modeling approach by using two different models to calculate the frequency of localized calcium signals (calcium puffs) from clustered IP3 receptor channels. The complexity of the full calcium system is here limited to the basic opening mechanism of the ion channels and, in the mathematical reduction simplifies to the calculation of a first passage time. Two models are then studied: (i) a hybrid model, where channel gating is treated stochastically, while calcium concentration is deterministic and (ii) a fully stochastic model with noisy channel gating and Brownian calcium ion motion. The second model utilises the recently developed two-regime method [M. B. Flegg, S. J. Chapman, and R. Erban, "The two-regime method for optimizing stochastic reaction-diffusion simulations," J. R. Soc., Interface 9, 859-868 (2012)] in order to simulate a large domain with precision required only near the Ca2+ absorbing channels. The expected time for a first channel opening that results in a calcium puff event is calculated. It is found that for a large diffusion constant, predictions of the interpuff time are significantly overestimated using the model (i) with a deterministic non-spatial calcium variable. It is thus demonstrated that the presence of diffusive noise in local concentrations of intracellular Ca2+ ions can substantially influence the occurrence of calcium signals. The presented approach and results may also be relevant for other cell-physiological first-passage time problems with small ligand concentration

  5. Statistical correlation of the soil incubation and the accelerated laboratory extraction methods to estimate nitrogen release rates of slow- and controlled-release fertilizers.

    Medina, L Carolina; Sartain, Jerry; Obreza, Thomas; Hall, William L; Thiex, Nancy J


    Several technologies have been proposed to characterize the nutrient release patterns of enhanced-efficiency fertilizers (EEFs) during the last few decades. These technologies have been developed mainly by manufacturers and are product-specific based on the regulation and analysis of each EEF product. Despite previous efforts to characterize nutrient release of slow-release fertilizer (SRF) and controlled-release fertilizer (CRF) materials, no official method exists to assess their nutrient release patterns. However, the increased production and distribution of EEFs in specialty and nonspecialty markets requires an appropriate method to verify nutrient claims and material performance. Nonlinear regression was used to establish a correlation between the data generated from a 180-day soil incubation-column leaching procedure and 74 h accelerated lab extraction method, and to develop a model that can predict the 180-day nitrogen (N) release curve for a specific SRF and CRF product based on the data from the accelerated laboratory extraction method. Based on the R2 > 0.90 obtained for most materials, results indicated that the data generated from the 74 h accelerated lab extraction method could be used to predict N release from the selected materials during 180 days, including those fertilizers that require biological activity for N release.

  6. Smoke Movement in an Atrium with a Fire with Low Rate of Heat Release

    Nielsen, Peter V.; Brohus, Henrik; Petersen, A. J.


    Results from small-scale experiments on smoke movement in an atrium are given, both with and without a vertical temperature gradient, and expressions for the smoke movement are developed on the basis of these experiments. Comparisons with a general analytical expression used for calculating...... the height to the location of the smoke layer are given. Furthermore, the paper discusses the air movement in a typical atrium exposed to different internal and external heat loads to elaborate on the use of the "flow element" expressions developed for smoke movement from a fire with a low rate of heat...

  7. On the Impact of the Fuel Dissolution Rate Upon Near-Field Releases From Nuclear Waste Disposal

    A Pereira


    Full Text Available Calculations of the impact of the dissolution of spent nuclear fuel on the release from a damaged canister in a KBS-3 repository are presented. The dissolution of the fuel matrix is a complex process and the dissolution rate is known to be one of the most important parameters in performance assessment models of the near-field of a geological repository. A variability study has been made to estimate the uncertainties associated with the process of fuel dissolution. The model considered in this work is a 3D model of a KBS-3 copper canister. The nuclide used in the calculations is Cs-135. Our results confirm that the fuel degradation rate is an important parameter, however there are considerable uncertainties associated with the data and the conceptual models. Consequently, in the interests of safety one should reduce, as far as possible, the uncertainties coupled to fuel degradation.

  8. An approach for estimating time-variable rates from geodetic time series

    Didova, Olga; Gunter, Brian; Riva, Riccardo; Klees, Roland; Roese-Koerner, Lutz


    There has been considerable research in the literature focused on computing and forecasting sea-level changes in terms of constant trends or rates. The Antarctic ice sheet is one of the main contributors to sea-level change with highly uncertain rates of glacial thinning and accumulation. Geodetic observing systems such as the Gravity Recovery and Climate Experiment (GRACE) and the Global Positioning System (GPS) are routinely used to estimate these trends. In an effort to improve the accuracy and reliability of these trends, this study investigates a technique that allows the estimated rates, along with co-estimated seasonal components, to vary in time. For this, state space models are defined and then solved by a Kalman filter (KF). The reliable estimation of noise parameters is one of the main problems encountered when using a KF approach, which is solved by numerically optimizing likelihood. Since the optimization problem is non-convex, it is challenging to find an optimal solution. To address this issue, we limited the parameter search space using classical least-squares adjustment (LSA). In this context, we also tested the usage of inequality constraints by directly verifying whether they are supported by the data. The suggested technique for time-series analysis is expanded to classify and handle time-correlated observational noise within the state space framework. The performance of the method is demonstrated using GRACE and GPS data at the CAS1 station located in East Antarctica and compared to commonly used LSA. The results suggest that the outlined technique allows for more reliable trend estimates, as well as for more physically valuable interpretations, while validating independent observing systems.


    HU TA


    Assess the steady-state flammability level at normal and off-normal ventilation conditions. The methodology of flammability analysis for Hanford tank waste is developed. The hydrogen generation rate model was applied to calculate the gas generation rate for 177 tanks. Flammability concentrations and the time to reach 25% and 100% of the lower flammability limit, and the minimum ventilation rate to keep from 100 of the LFL are calculated for 177 tanks at various scenarios.

  10. Predictive Information Rate in Discrete-time Gaussian Processes

    Abdallah, Samer A


    We derive expressions for the predicitive information rate (PIR) for the class of autoregressive Gaussian processes AR(N), both in terms of the prediction coefficients and in terms of the power spectral density. The latter result suggests a duality between the PIR and the multi-information rate for processes with mutually inverse power spectra (i.e. with poles and zeros of the transfer function exchanged). We investigate the behaviour of the PIR in relation to the multi-information rate for some simple examples, which suggest, somewhat counter-intuitively, that the PIR is maximised for very `smooth' AR processes whose power spectra have multiple poles at zero frequency. We also obtain results for moving average Gaussian processes which are consistent with the duality conjectured earlier. One consequence of this is that the PIR is unbounded for MA(N) processes.

  11. Studies on applicability of press-coated tablets using hydroxypropylcellulose (HPC) in the outer shell for timed-release preparations.

    Fukui, E; Uemura, K; Kobayashi, M


    Press-coated tablets, containing diltiazem hydrochloride (DIL) in the core tablet and coated with hydroxypropylcellulose (HPC) as the outer shell, were examined for applicability as timed-release tablets with a predetermined lag time and subsequent rapid drug release phase. Various types of press-coated tablets were prepared using a rotary tabletting machine and their DIL dissolution behavior was evaluated by the JP paddle method. The results indicated that tablets with the timed-release function could be prepared, and that the lag times were prolonged as the viscosity of HPC and the amount of the outer shell were increased. The lag times could be controlled widely by the above method, however, the compression load had little effect. Two different kinds of timed-release press-coated tablets that showed lag times of 3 and 6 h in the in vitro test (denoted PCT(L3) and PCT(L6), respectively) were administered to beagle dogs. DIL was first detected in the plasma more than 3 h after administration, and both tablets showed timed-release. The lag times showed a good agreement between the in vivo and in vitro tests in PCT(L3). However, the in vivo lag times were about 4 h in PCT(L6) and were much shorter than the in vitro lag time. The dissolution test was performed at different paddle rotation speeds, and good agreement was obtained between the in vivo and in vitro lag times at 150 rpm. This suggested that the effects of gastrointestinal peristalsis and contraction should also be taken into consideration for the further development of drug delivery systems.

  12. 川芎嗪自乳化缓释固体分散体释放度测定方法研究%Study on Release Rate of TMP Self-emulsifying Release Solid Dispersion

    陈道阳; 陈晓丹; 王利胜


    Objective: To establish release rate determination methods of TMP self-emulsifying release solid dispersion. Methods: HPLC was applied to determine the content of TMP, and different effects on release rate of TMP self-emulsifying release solid dispersion were studied in vitro. Results: The release medium was degassed pure water, the rotation speed was 50r · min-1. Conclusion: A good method to determine release rate of TMP self-emulsifying release solid dispersion was established, providing a basis to evaluate and control the quality of drugs.%目的:建立川芎嗪自乳化缓释固体分散体释放度测定方法.方法:采用HPLC法测定川芎嗪自乳化缓释固体分散体中TMP的含量,考察相关因素对其体外释药的影响.结果:以转篮法为溶出度测定方法,释放介质为脱气纯水,转速为50r/min.结论:建立了良好的川芎嗪自乳化缓释固体分散体释放度测定方法,为评价和控制该药的质量提供依据.

  13. Determining phosphorus release rates to runoff from selected Alberta soils using laboratory rainfall simulation.

    Wright, Charles R; Amrani, Mohamed; Akbar, Muhammad A; Heaney, Danial J; Vanderwel, Douwe S


    Phosphorus losses from agricultural land can cause accelerated eutrophication of surface water bodies. This study evaluated the use of soil test phosphorus (STP) levels to predict dissolved inorganic phosphorus (DIP) concentrations in runoff water from agricultural soils using laboratory rainfall simulation. The objectives of this study were to determine (i) to what extent STP concentrations can be used as a basis to predict P losses from Alberta soils and (ii) how extended rainfall simulation run times affected DIP losses. Soil samples collected from a total of 38 field sites, widely scattered throughout the southern half of Alberta, were subjected to rainfall simulation in the laboratory. The STP concentrations were determined using Miller-Axley, Norwest, Kelowna, Modified Kelowna Mehlich-III, and distilled water extraction methods. Each rainfall simulation event lasted for at least 90 min. Runoff samples were collected in time series for the duration of each simulation, during two distinct runoff intervals: (i) for the first 30 min of continuous runoff (T30) and (ii) for 40 min during runoff equilibrium (Teq). For all the STP extractants and both runoff intervals, the relationship with DIP-flow-weighted mean concentration (FWMC) was linear and highly significant with r2 values ranging from 0.74 to 0.96. However, the slopes of the resulting regression lines were, on average, 1.85 times greater for the T30 runoff interval over those computed for the Teq interval. Thus experimental methodology greatly influenced regression parameters, suggesting that more work was needed to verify these relationships under natural conditions. In addition, with many of the r2 values greater than 0.90 there would be little, if any, benefit derived by including soil properties in regression analysis.

  14. Space-time encoding for high frame rate ultrasound imaging

    Misaridis, Thanssis; Jensen, Jørgen Arendt


    Frame rate in ultrasound imaging can be dramatically increased by using sparse synthetic transmit aperture (STA) beamforming techniques. The two main drawbacks of the method are the low signal-to-noise ratio (SNR) and the motion artifacts, that degrade the image quality. In this paper we propose ...

  15. Time-Space Evolution of Seismic Strain Release in the Area Shocked by the August 24-October 30 Central Italy Seismic Sequence

    Barani, Simone; Mascandola, Claudia; Serpelloni, Enrico; Ferretti, Gabriele; Massa, Marco; Spallarossa, Daniele


    In this study, we analyze the space-time evolution of the seismic strain release in the area shocked by the still ongoing Italian Central Apennines seismic crisis started on August 24, 2016 and culminated with the October 30 main shock of M w 6.5. Specifically, we examine the variation in time and space of the seismic strain release rate with the aim of identifying the presence of peculiar seismicity patterns, such as seismic gaps, according to the seismic cycle theory. To this end, seismic strain rates are checked for consistency with strain rates from GPS measurements to possibly adjust them for missing events due to limited seismic catalog extension or incompleteness at large magnitudes. Our results has revealed that the seismic crisis followed a long-term quiescence of about 310 years, characterized by the absence of M6.5+ earthquakes, and marked by an almost steady release of seismic deformation. Such temporal gap started after the occurrence of two nearby strong events in 1703 (Valnerina and L'Aquila earthquakes with magnitudes of 6.9 and 6.7, respectively) and terminated with the beginning of the current Central Apennines seismic crisis.

  16. Impact of gonadotropin-releasing hormone antagonist addition on pregnancy rates in gonadotropin-stimulated intrauterine insemination cycles

    Shikha Jain


    Full Text Available OBJECTIVES: The objective of the study is to evaluate the efficacy of gonadotropin-releasing hormone (GnRH antagonist in improving clinical pregnancy rate in gonadotropin-stimulated intrauterine insemination (IUI cycles in patients of unexplained infertility. STUDY DESIGN: This was a prospective, randomized case-controlled study. SETTINGS: The study was conducted in the infertility clinic of a tertiary care center. MATERIALS AND METHODS: Four hundred twenty-seven women undergoing IUI following controlled ovarian stimulation with gonadotropins (recombinant follicle-stimulating hormone [r-FSH] 75 IU/day were randomly divided into two groups. Women in Group I received GnRH antagonist (Cetrorelix 0.25 mg/day in a multiple dose flexible protocol. Women in Group II received r-FSH alone. Ovulatory trigger was given with human chorionic gonadotropin 5000 IU when dominant follicle was ≥18 mm. IUI was performed within 44-48 h. Both groups received similar luteal phase support. Primary outcome measure was clinical pregnancy rate. The trial was powered to detect an absolute increase in clinical pregnancy rate by 13% from an assumed 20% clinical pregnancy rate in the control group, with an alpha error level of 0.05 and a beta error level of 0.20. RESULTS: Clinical pregnancy rate in Groups I and II was 27.6% (n = 56 and 26.5% (n = 54, respectively (P=0.800. Ongoing pregnancy and multiple pregnancy rates were likewise similar between the groups. CONCLUSIONS: Addition of GnRH antagonist to gonadotropin-stimulated IUI cycles results in no significant difference in clinical pregnancy rate.

  17. Solar release time of solar energetic particles and associated acceleration source in corona


    Solar energetic particles (SEPs) are accelerated in corona at an early phase of solar energetic particle events (SEPE). The acceleration mechanism of SEPs in corona can only be inferred from an analysis of multi-band observational data, as the observation of SEPs is usually made around 1AU. In this context,people have investigated spectrums, charge state, solar release time (SRT), and multi-band data of SEPEs, in an attempt to judge the acceleration mechanism of SEPs. The SRT computation of SEPs is an important and commonly used approach to study the acceleration mechanism of SEPs in corona.This paper reviews some important findings concerning the SRT computation of SEPs, and analyzes different merits of each approach for such calculation, based on a range of SEPE case studies. This paper also analyzes and discusses both possible and actual acceleration mechanisms of a number of SEPEs, by calculating the SRT of the SEPEs. Finally, the paper summarizes the possible problems in studying an acceleration mechanism of SEPEs inferred from the SRT of SEP.

  18. Generation of low-timing-jitter femtosecond pulse trains with 2 GHz repetition rate via external repetition rate multiplication.

    Chen, Jian; Sickler, Jason W; Fendel, Peter; Ippen, Erich P; Kärtner, Franz X; Wilken, Tobias; Holzwarth, Ronald; Hänsch, Theodor W


    Generation of low-timing-jitter 150 fs pulse trains at 1560 nm with 2 GHz repetition rate is demonstrated by locking a 200 MHz fundamental polarization additive-pulse mode-locked erbium fiber laser to high-finesse external Fabry-Perot cavities. The timing jitter and relative intensity noise of the repetition-rate multiplied pulse train are investigated.

  19. In vivo real-time monitoring of aphrodisiac pheromone release of small white cabbage butterflies (Pieris rapae).

    Li, Yue; Mathews, Robert A


    The study of insect behavior is of practical importance for developing possible control methods in Integrated Pest Management. Currently, one model of butterfly mating behavior suggests that the initial location of potential mates occurs visually followed by the release of one or more short-range male aphrodisiac pheromones. This model is supported by data obtained from field observations and inferences based on the behavioral effects of chemicals extracted or isolated using indirect and offline techniques. In this study, we performed in vivo real-time monitoring of the male aphrodisiac pheromones released by the small white cabbage male butterfly (Pieris rapae Linnaeus) using confined direct analysis in real time (cDART) mass spectrometry. cDART is a new method easily adapted to the study in real time of chemicals released into the environment by virtually any insect. The major compound released by the male Pieris rapae was identified as ferrulactone. The experimental results reported here indicate that the release of ferrulactone occurs less than 1s after the male visualizes its partner, and reaches a maximum after about one half minute. This study is the first reported in vivo detection and monitoring of butterfly male aphrodisiac pheromones in real time.

  20. Identify source location and release time for pollutants undergoing super-diffusion and decay: Parameter analysis and model evaluation

    Zhang, Yong; Sun, HongGuang; Lu, Bingqing; Garrard, Rhiannon; Neupauer, Roseanna M.


    Backward models have been applied for four decades by hydrologists to identify the source of pollutants undergoing Fickian diffusion, while analytical tools are not available for source identification of super-diffusive pollutants undergoing decay. This technical note evaluates analytical solutions for the source location and release time of a decaying contaminant undergoing super-diffusion using backward probability density functions (PDFs), where the forward model is the space fractional advection-dispersion equation with decay. Revisit of the well-known MADE-2 tracer test using parameter analysis shows that the peak backward location PDF can predict the tritium source location, while the peak backward travel time PDF underestimates the tracer release time due to the early arrival of tracer particles at the detection well in the maximally skewed, super-diffusive transport. In addition, the first-order decay adds additional skewness toward earlier arrival times in backward travel time PDFs, resulting in a younger release time, although this impact is minimized at the MADE-2 site due to tritium's half-life being relatively longer than the monitoring period. The main conclusion is that, while non-trivial backward techniques are required to identify pollutant source location, the pollutant release time can and should be directly estimated given the speed of the peak resident concentration for super-diffusive pollutants with or without decay.

  1. Effects of Vibration and G-Loading on Heart Rate, Breathing Rate, and Response Time

    Godinez, Angelica; Ayzenberg, Ruthie; Liston, Dorian B.; Stone, Leland S.


    Aerospace and applied environments commonly expose pilots and astronauts to G-loading and vibration, alone and in combination, with well-known sensorimotor (Cohen, 1970) and performance consequences (Adelstein et al., 2008). Physiological variables such as heart rate (HR) and breathing rate (BR) have been shown to increase with G-loading (Yajima et al., 1994) and vibration (e.g. Guignard, 1965, 1985) alone. To examine the effects of G-loading and vibration, alone and in combination, we measured heart rate and breathing rate under aerospace-relevant conditions (G-loads of 1 Gx and 3.8 Gx; vibration of 0.5 gx at 8, 12, and 16 Hz).

  2. Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis

    Ling, K.H.; Hanzlik, R.P.


    Liver microsomes from phenobarbital-induced rats oxidize toluene to a mixture of benzyl alcohol plus o-, m- and p-cresol (ca. 69:31). Stepwise deuteration of the methyl group causes stepwise decreases in the yield of benzyl alcohol relative to cresols (ca. 24:76 for toluene-d3). For benzyl alcohol formation from toluene-d3 DV = 1.92 and D(V/K) = 3.53. Surprisingly, however, stepwise deuteration induces stepwise increases in total oxidation, giving rise to an inverse isotope effect overall (DV = 0.67 for toluene-d3). Throughout the series (i.e. d0, d1, d2, d3) the ratios of cresol isomers remain constant. These results are interpreted in terms of product release for benzyl alcohol being slower than release of cresols (or their epoxide precursors), and slow enough to be partially rate-limiting in turnover. Thus metabolic switching to cresol formation causes a net acceleration of turnover.

  3. University Instructors' Ratings Profiles: Stability Over Time, and Disciplinary Differences.

    Hativa, Nira; Raviv, Alona


    A study compared the teaching behaviors of University of Tel Aviv (Israel) physics and chemistry faculty over two consecutive years, at mid- and end-semester. Findings indicate a high degree of stability in behaviors over time, with no clear-cut improvement during a semester except for faculty undertaking special instructional improvement…

  4. Energy Release Rate in hydraulic fracture: can we neglect an impact of the hydraulically induced shear stress?

    Wrobel, Michal; Piccolroaz, Andrea


    A novel hydraulic fracture (HF) formulation is introduced which accounts for the hydraulically induced shear stress at the crack faces. It utilizes a general form of the elasticity operator alongside a revised fracture propagation condition based on the critical value of the energy release rate. It is shown that the revised formulation describes the underlying physics of HF in a more accurate way and is in agreement with the asymptotic behaviour of the linear elastic fracture mechanics. A number of numerical simulations by means of the universal HF algorithm previously developed in Wrobel & Mishuris (2015) are performed in order to: i) compare the modified HF formulation with its classic counterpart and ii) investigate the peculiarities of the former. Computational advantages of the revised HF model are demonstrated. Asymptotic estimations of the main solution elements are provided for the cases of small and large toughness. The modified formulation opens new ways to analyse the physical phenomenon of HF ...

  5. Releasable activity and maximum permissible leakage rate within a transport cask of Tehran Research Reactor fuel samples

    Rezaeian Mahdi


    Full Text Available Containment of a transport cask during both normal and accident conditions is important to the health and safety of the public and of the operators. Based on IAEA regulations, releasable activity and maximum permissible volumetric leakage rate within the cask containing fuel samples of Tehran Research Reactor enclosed in an irradiated capsule are calculated. The contributions to the total activity from the four sources of gas, volatile, fines, and corrosion products are treated separately. These calculations are necessary to identify an appropriate leak test that must be performed on the cask and the results can be utilized as the source term for dose evaluation in the safety assessment of the cask.

  6. Long-range correlations in heart rate variability during computer-mouse work under time pressure

    Jiang, Dineng; He, Mulu; Qiu, Yihong; Zhu, Yisheng; Tong, Shanbao


    The aim of this study was to investigate the influences of time pressure on long-range correlations in heart rate variability (HRV), the effects of relaxation on the cardiovascular regulation system and the advantages of detrended fluctuation analysis (DFA) over the conventional power spectral analysis in discriminating states of the cardiovascular systems under different levels of time pressure. Volunteer subjects ( n=10, male/female=5/5) participated in a computer-mouse task consisting of five sessions, i.e. baseline session (BSS) which was free of time pressure, followed by sessions with 80% (SS80), 100% (SS100), 90% (SS90) and 150% (SS150) of the baseline time. Electrocardiogram (ECG) and task performance were recorded throughout the experiments. Two rest sessions before and after the computer-mouse work, i.e. RS1 and RS2, were also recorded as comparison. HRV series were subsequently analyzed by both conventional power spectral analysis and detrended fluctuation analysis (DFA). The long-term scaling exponent α2 by DFA was significantly lower in SS80 than that in other sessions. It was also found that short-term release of time pressure had positive influences on the cardiovascular system, i.e. the α2 in RS2 was significantly higher than that in SS80, SS100 and SS90. No significant differences were found between any two sessions by conventional power spectral analysis. Our results showed that DFA performed better in discriminating the states of cardiovascular autonomic modulation under time pressure than the conventional power spectral analysis.

  7. Air renewal times and ventilation rate calculations for underground workings using radioactive measurement

    Ayman A. El-Abnoudy⇑; Sayed F. Hassan


    Potential alpha emitters are of prime concern to the ventilation engineer due to their rapid concentration increasing once radon released in the mine atmosphere, causing tissue irradiation and lung cancer. Studying of the time based variations of the natural ventilation in tunnels and their relationship to the external parameters contribute to the air circulation assessment. Due to the continuous and high fluctu-ation of the meteorological conditions affecting the air circulation and intensity through the underground workings, there is a difficulty in the natural ventilation assessment by only the ordinary meteorological measurements. So, in this paper, the possibility of using the radioactive measurements, allowing for the air aging and ventilation quality to be qualified, is investigated through three different underground structures. Referring to the most confined structure of them, results show that one structure has a better exchange rate by a factor 1.8 and the other has the best rate by a factor 2.1. This parameter can be linked to the operating costs and size of a future ventilation system.

  8. Changes in cortisol release and heart rate and heart rate variability during the initial training of 3-year-old sport horses.

    Schmidt, Alice; Aurich, Jörg; Möstl, Erich; Müller, Jürgen; Aurich, Christine


    Based on cortisol release, a variety of situations to which domestic horses are exposed have been classified as stressors but studies on the stress during equestrian training are limited. In the present study, Warmblood stallions (n=9) and mares (n=7) were followed through a 9 respective 12-week initial training program in order to determine potentially stressful training steps. Salivary cortisol concentrations, beat-to-beat (RR) interval and heart rate variability (HRV) were determined. The HRV variables standard deviation of the RR interval (SDRR), RMSSD (root mean square of successive RR differences) and the geometric means standard deviation 1 (SD1) and 2 (SD2) were calculated. Nearly each training unit was associated with an increase in salivary cortisol concentrations (pCortisol release varied between training units and occasionally was more pronounced in mares than in stallions (p<0.05). The RR interval decreased slightly in response to lunging before mounting of the rider. A pronounced decrease occurred when the rider was mounting, but before the horse showed physical activity (p<0.001). The HRV variables SDRR, RMSSD and SD1 decreased in response to training and lowest values were reached during mounting of a rider (p<0.001). Thereafter RR interval and HRV variables increased again. In contrast, SD2 increased with the beginning of lunging (p<0.05) and no changes in response to mounting were detectable. In conclusion, initial training is a stressor for horses. The most pronounced reaction occurred in response to mounting by a rider, a situation resembling a potentially lethal threat under natural conditions.

  9. Effects of pH, Temperature, Dissolved Oxygen, and Flow Rate on Phosphorus Release Processes at the Sediment and Water Interface in Storm Sewer

    Haiyan Li


    Full Text Available The effects of pH, temperature, dissolved oxygen (DO, and flow rate on the phosphorus (P release processes at the sediment and water interface in rainwater pipes were investigated. The sampling was conducted in a residential storm sewer of North Li Shi Road in Xi Cheng District of Beijing on August 3, 2011. The release rate of P increased with the increase of pH from 8 to 10. High temperature is favorable for the release of P. The concentration of total phosphorus (TP in the overlying water increased as the concentration of DO decreased. With the increase of flow rate from 0.7 m s−1 to 1.1 m s−1, the concentration of TP in the overlying water increased and then tends to be stable. Among all the factors examined in the present study, the flow rate is the primary influence factor on P release. The cumulative amount of P release increased with the process of pipeline runoff in the rainfall events with high intensities and shorter durations. Feasible measures such as best management practices and low-impact development can be conducted to control the P release on urban sediments by slowing down the flow rate.

  10. Modulation of drug release rate of diltiazem-HCl from hydrogel matrices of succinic acid-treated ispaghula husk.

    Gohel, M C; Amin, A F; Chhabaria, M T; Panchal, M K; Lalwani, A N


    The feasibility of using succinic acid-treated ispaghula husk in matrix-based tablets of diltiazem-HCl was investigated. The sample prepared using 4:1 weight ratio of ispaghula husk to succinic acid showed improved swelling and gelling. A 3(2) factorial design was employed to investigate the effect of amount of succinic acid-treated ispaghula husk and dicalcium phosphate (DCP) on the percentage of the drug dissolved in 60, 300, and 480 min from the compressed tablets. The results of multiple linear regression analysis revealed that the significance of the amount of succinic acid-treated ispaghula husk was greater in magnitude than that of the amount of DCP in controlling the drug release. Acceptable batches were identified from a contour plot with constraints on the percentage drug released at the three sampling times. A mathematical model was also evolved to describe the entire dissolution profile. The results of F-test revealed that the Higuchi model fits well to the in vitro dissolution data. The tablets showed considerable radial and axial swelling in distilled water. Succinic acid-treated ispaghula husk can be used as an economical hydrophilic matrixing agent.

  11. A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction

    Prapatsorn Techawanitchai, Naokazu Idota, Koichiro Uto, Mitsuhiro Ebara and Takao Aoyagi


    Full Text Available We demonstrate a timed explosive drug release from smart pH-responsive hydrogels by utilizing a phototriggered spatial pH-jump reaction. A photoinitiated proton-releasing reaction of o-nitrobenzaldehyde (o-NBA was integrated into poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide (P(NIPAAm-co-CIPAAm hydrogels. o-NBA-hydrogels demonstrated the rapid release of protons upon UV irradiation, allowing the pH inside the gel to decrease to below the pKa value of P(NIPAAm-co-CIPAAm. The generated protons diffused gradually toward the non-illuminated area, and the diffusion kinetics could be controlled by adjusting the UV irradiation time and intensity. After irradiation, we observed the enhanced release of entrapped L-3,4-dihydroxyphenylalanine (DOPA from the gels, which was driven by the dissociation of DOPA from CIPAAm. Local UV irradiation also triggered the release of DOPA from the non-illuminated area in the gel via the diffusion of protons. Conventional systems can activate only the illuminated region, and their response is discontinuous when the light is turned off. The ability of the proposed pH-jump system to permit gradual activation via proton diffusion may be beneficial for the design of predictive and programmable devices for drug delivery.

  12. Vernonia cinerea Less. supplementation and strenuous exercise reduce smoking rate: relation to oxidative stress status and beta-endorphin release in active smokers

    Yankai Araya


    Full Text Available Abstract Purpose The aim of this study was to evaluate the effects of Vernonia cinerea Less. (VC supplementation and exercise on oxidative stress biomarkers, beta-endorphin release, and the rate of cigarette smoking. Methods Volunteer smokers were randomly divided into four groups: group 1: VC supplement; group 2: exercise with VC supplement; group 3: exercise; and group 4: control. VC was prepared by wash and dry techniques and taken orally before smoking, matching the frequency of strenuous exercise (three times weekly. Before and after a two month period, exhaled carbon monoxide (CO, blood oxidative stress (malondialdehyde [MDA], nitric oxide [NOx], protein hydroperoxide [PrOOH] and total antioxidant capacity [TAC], beta-endorphin and smoking rate were measured, and statistically analyzed. Results In Group 1, MDA, PrOOH, and NOx significantly decreased, whereas TAC increased (p 0.05. In Group 3, MDA, PrOOH, NOx, TAC, and beta-endorphin levels increased significantly (p 0.05. All groups had lower levels of CO after the intervention. The smoking rate for light cigarette decreased in group 2(62.7%, 1(59.52%, 3 (53.57% and 4(14.04%, whereas in self-rolled cigarettes it decreased in group 1 (54.47%, 3 (42.30%, 2 (40% and 4 (9.2%. Conclusion Supplementation with Vernonia cinerea Less and exercise provided benefit related to reduced smoking rate, which may be related to oxidaive stress and beta-endorphine levels.

  13. Proton transfer reaction mass spectrometry and time intensity perceptual measurement of flavor release from lipid emulsions using trained human subjects.

    Frank, Damian; Appelqvist, Ingrid; Piyasiri, Udayasika; Wooster, Tim J; Delahunty, Conor


    The effect of the fat component of liquid emulsions on dynamic "in-nose" flavor release was examined using a panel of trained human subjects (n = 6), proton transfer reaction mass spectrometry (PTR-MS), and time intensity (TI) sensory evaluation. A rigorous breathing and consumption protocol was developed, which synchronized subjects' breathing cycles and also the timing of sample introduction. Temporal changes in volatile release were measured in exhaled nostril breath by real-time PTR-MS. Corresponding changes in the perceived odor intensity could also be simultaneously measured using a push button TI device. The method facilitated accurate examination of both "preswallow" and "postswallow" phases of volatile release and perception. Volatile flavor compounds spanning a range of octanol/water partition coefficient (K(o/w)) values (1-1380) were spiked into water (0% fat) or lipid emulsions with various fat contents (2, 5, 10, and 20% fat). Replicate samples for each fat level were consumed according to the consumption protocol by six subjects. Statistical comparisons were made at the individual level and across the group for the effects of changes in the food matrix, such as fat content, on both pre- and postswallow volatile release. Significant group differences in volatile release parameters including area under the concentration curve (AUC) and maximum concentration (I(max)) were measured according to the lipid content of emulsions and volatile K(o/w). In a second experiment, using single compounds (2-heptanone, ethyl butanoate, and ethyl hexanoate), significant decreases in both in-nose volatile release and corresponding perceived odor intensities were measured with increasing fat addition. Overall, the effect of fat on in vivo release conformed to theory; fat had little effect on compounds with low K(o/w) values, but increased for volatiles with higher lipophilicity. In addition, significant pre- and postswallow differences were observed in AUC and I(max), as

  14. A GTPase chimera illustrates an uncoupled nucleotide affinity and release rate, Providing insight into the activation mechanism

    Guilfoyle, Amy P.; Deshpande, Chandrika N.; Font Sadurni, Josep


    for GDP release, or, alternatively, the movement is a consequence of release. To gain additional insight into the sequence of events leading to GDP release, we have created a chimeric protein comprised of Escherichia coli NFeoB and the G5 loop from the human Giα1 protein. The protein chimera retains...

  15. Spore release of Bremia lactucae on lettuce is affected by timing of light initiation and decrease in relative humidity

    Su, H.; Bruggen, van A.H.C.; Subbarao, K.V.


    A suction-impaction mini-spore trap was developed to study the effect of light initiation and decreasing relative humidity (RH) on spore release of Bremia lactucae in a controlled environment. Three light periods (from 0400 to 1600, 0600 to 1800, and 0800 to 2000 h, circadian time) at a constant RH

  16. Time-delay polynomial networks and rates of approximation

    Irwin W. Sandberg


    Full Text Available We consider a large family of finite memory causal time-invariant maps G from an input set S to a set of ℝ-valued functions, with the members of both sets of functions defined on the nonnegative integers, and we give an upper bound on the error in approximating a G using a two-stage structure consisting of a tapped delay line and a static polynomial network N . This upper bound depends on the degree of the multivariable polynomial that characterizes N. Also given is a lower bound on the worst-case error in approximating a G using polynomials of a fixed maximum degree. These upper and lower bounds differ only by a multiplicative constant. We also give a corresponding result for the approximation of not-necessarily-causal input–output maps with inputs and outputs that may depend on more than one variable. This result is of interest, for example, in connection with image processing.

  17. Financial modeling in medicine: cash flow, basic metrics, the time value of money, discount rates, and internal rate of return.

    Lexa, Frank James; Berlin, Jonathan W


    In this article, the authors cover tools for financial modeling. Commonly used time lines and cash flow diagrams are discussed. Commonly used but limited terms such as payback and breakeven are introduced. The important topics of the time value of money and discount rates are introduced to lay the foundation for their use in modeling and in more advanced metrics such as the internal rate of return. Finally, the authors broach the more sophisticated topic of net present value.

  18. Technical note: Reduced pulsation chamber vacuum at normal pulsation rate and ratio provides adequate prestimulation to induce oxytocin release and milk ejection while simultaneous milk flow is prevented.

    Neuheuser, Anna-Lena; Belo, Claire; Bruckmaier, Rupert M


    In the present study we investigated the milking characteristics and the oxytocin release in dairy cows milked after either manual prestimulation or a premilking period with pulsating liners at normal pulsation rate (60) and ratio (60:40) while the pulsation chamber vacuum (PCV) was reduced to 20 kPa to prevent the opening of the liners. During the milking trial with 8 cows the PCV reduction was started either before attachment (PCV-1) or immediately after attachment (PCV-2) of the teat cups. Milk yields, total milking times, average milk flows, peak flow rates, the duration of milk flow plateaus, and the duration of milk flow declines did not differ among the 3 treatments. Only the time to reach peak milk flow was prolonged when the vacuum reduction was started after teat cup attachment (PCV-2). In this treatment, milk flow >200 g/min already occurred during the premilking period, resulting in bimodal milk flow curves. In 5 of the 8 cows, plasma oxytocin (OT) concentrations were measured from -2 min before the start of milking until 3 min of milking to compare the OT release in response to manual prestimulation and during PCV-1. In both treatments, OT increased similarly and remained elevated until the end of measurements. Consequently, the areas under the curve of OT concentrations did not differ between treatments. In conclusion, milking performance is similar if milking is performed after manual prestimulation or after normal pulsation at reduced PCV. To prevent milk flow during the prestimulation period, it is of crucial importance to start the reduction of the PCV before cluster attachment. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  19. Spinal release of the amino acids with a time course in a rat model of postoperative pain

    WANG Yun; YUE Yun; SHI Lin; WU An-shi; FENG Chun-sheng; NI Cheng


    Background The mechanisms underlying postoperative pain remain unclear. Neurotransmitters of excitatory and inhibitory amino acids play an important role in the transmission and modulation of pain in the spinal dorsal horn. This study aimed to investigate the changes of release of excitatory and inhibitory amino acids in the spinal cord during postoperative pain and to provide a novel theoretical basis for postoperative pain management.Methods Loop microdialysis catheters were implanted subarachnoidally via the atlanto-occipital membrane in 16 healthy Sprague-Dawley rats. All rats without neural deficits were divided into two groups, Group A and Group B,following 5 days of recovery. The tubes for microdialysis were connected and 25 μl microdialysate sample for baseline value was collected after one-hour washout in each rat. A plantar incision in the right hind paws of rats in Group A were performed under 1.2% isoflurane. All rats in Group B were only anesthetized by 1.2% isoflurane for the same duration.The microdialysate samples were collected at 3 hours, 1 day, 2 days and 3 days after the incision (or isoflurane anesthesia in Group B) in both groups. The cumulative pain scores were also assessed at the above time-points. The amino acids in the microdialysate samples were tested using high performance liquid chromatography.Results Within Group A, the release of aspartate and glutamate at 3 hours after the incision was significantly higher than the baseline values and the release of glycine at 1 day after the incision significantly increased compared with the baseline values (P<0.01). Within Group B, the release of neurotransmitters at each time point had no significant difference compared with the baseline values (P>0.05). The release of aspartate and glutamate at 3 hours after the incision in Group A was significantly higher than that in Group B (P<0.01). The release of glycine at 1 day after the incision in Group A significantly increased compared with

  20. Modelling flow phenomena in time dependent store release from transonic aircraft

    MacLucas, David A


    Full Text Available Computational Fluid Dynamics is routinely used in clearance of stores for carriage and release from aircraft in the transonic range of flight. A well-known validation case is modelled in this study, for which aerodynamic loads have been compared...

  1. Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

    Bajpai AK


    Full Text Available Abstract Background Many anticancer agents have poor water solubility and therefore the development of novel delivery systems for such molecules has received significant attention. Nanocarriers show great potential in delivering therapeutic agents into the targeted organs or cells and have recently emerged as a promising approach to cancer treatments. The aim of this study was to prepare and use poly-2-hydroxyethyl methacrylate (PHEMA nanoparticles for the controlled release of the anticancer drug doxorubicin. Results PHEMA nanoparticles have been synthesized and characterized using FTIR and scanning electron microscopy (SEM, particle size analysis and surface charge measurements. We also studied the effects of various parameters such as percent loading of drugs, chemical architecture of the nanocarriers, pH, temperature and nature of the release media on the release profiles of the drug. The chemical stability of doxorubicin in PBS was assessed at a range of pH. Conclusion Suspension polymerization of 2-hydroxyethyl methacrylate (HEMA results in the formation of swellable nanoparticles of defined composition. PHEMA nanoparticles can potentially be used for the controlled release of the anticancer drug doxorubicin.

  2. Release of quantum dot nanoparticles in porous media: Role of cation exchange and aging time

    Understanding the fate and transport of engineered nanoparticles (ENPs) in subsurface environments is required for developing the best strategy for waste management and disposal of these materials. In this study, the deposition and release of quantum dot (QD) nanoparticles were studied in saturated ...

  3. Fabrication of thin SU-8 cantilevers: initial bending, release and time stability

    Keller, Stephan Urs; Haefliger, D.; Boisen, Anja


    , the rotational deformation at the clamping point allowed a qualitative assessment of the device release from the fluorocarbon-coated substrate. The change of these parameters during several months of storage at ambient temperature was investigated in detail. The introduction of a long hard bake in an oven after...

  4. Success rate, efficacy, and safety/tolerability of overnight switching from immediate- to extended-release pramipexole in advanced Parkinson's disease.

    Schapira, A H V; Barone, P; Hauser, R A; Mizuno, Y; Rascol, O; Busse, M; Debieuvre, C; Fraessdorf, M; Poewe, W


    For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight switch from adjunctive IR to ER. Levodopa users experiencing motor fluctuations were randomized to adjunctive double-blind (DB) placebo, IR, or ER. Amongst completers of ≥18 weeks, ER recipients were kept on DB ER, whilst IR recipients were switched overnight to DB ER at unchanged daily dosage. After a DB week, switch success was assessed. During the next 5 weeks, all patients underwent ER titration to optimal open-label maintenance dosage. One week post-switch, 86.2% of 123 IR-to-ER and 83.8% of 105 ER-to-ER patients had ≤15% (or ≤3-point, for pre-switch scores ≤20) increase on UPDRS Parts II + III, and 77.9% (of 122) and 70.2% (of 104) had ≤1-h increase in daily OFF-time. At 32 weeks, the groups showed comparable improvements from DB baseline (pramipexole inception), including, on UPDRS II + III, adjusted mean (SE) changes of -14.8 (1.5) for IR-to-ER and -13.3 (1.6) for ER-to-ER. Rates of premature discontinuation owing to adverse events were 6.5% for IR-to-ER and 4.9% for ER-to-ER. By OFF-time and UPDRS criteria, majorities of patients with advanced PD were successfully switched overnight from pramipexole IR to ER at unchanged daily dosage. During subsequent maintenance, pramipexole showed sustained efficacy, safety, and tolerability, regardless of formulation (IR or ER) in the preceding DB trial. © 2012 The Author(s) European Journal of Neurology © 2012 EFNS.

  5. A tubular gelatin scaffold capable of the time-dependent controlled release of epidermal growth factor and mitomycin C.

    Zhu, Jixiang; Yang, Fanwen; He, Fupo; Tian, Xiumei; Tang, Shuo; Chen, Xiaoming


    A tubular gelatin scaffold for the time-dependent controlled release of epidermal growth factor (EGF) and mitomycin C (MMC) was fabricated. EGF was incorporated using silk fibroin carriers, and MMC was planted using polylactide (PLA) microspheres. The relationship between scaffold properties and crosslinking degrees was evaluated. As the crosslinking degree was increased from 23.7% to 65.3%, the mechanical properties of the scaffold obviously improved, and the compressive modulus increased to approximately 65kPa. The mass degradation of the scaffold was also controlled from 9 days to approximately 1 month. In vitro release tests indicated that the scaffold mainly released EGF in the early period and MMC in the later period. Urethral epithelial cells (UECs) and urethral scar derived fibroblast cells (UFCs) were coseeded in the scaffold at a ratio of 1:1. After 9 days of coculture, immunostaining results displayed that the proportion of UECs continuously increased to approximately 71%. These changes in cell proportion were confirmed by the results of Western blot analysis. Therefore, the scaffold promoted the growth but inhibited the regeneration of UFCs. This scaffold for time-dependent controlled release of multiple biofactors may be potentially useful in urethral reconstruction and other tissue engineering studies.

  6. Nanodomain coupling explains Ca2+ independence of transmitter release time course at a fast central synapse


    eLife digest The nervous system sends information around the body in the form of electrical signals that travel through cells called neurons. However, these electrical signals cannot cross the synapses between neurons. Instead, the information is carried across the synapse by molecules called neurotransmitters. Calcium ions control the release of neurotransmitters. There is a high concentration of calcium ions outside the neuron but they are not able to pass through the cell membrane under no...

  7. Theoretical prediction of energy release rate for interface crack initiation by thermal stress in environmental barrier coatings for ceramics

    Kawai, E.; Umeno, Y.


    As weight reduction of turbines for aircraft engines is demanded to improve fuel consumption and curb emission of carbon dioxide, silicon carbide (SiC) fiber reinforced SiC matrix composites (SiC/SiC) are drawing enormous attention as high-pressure turbine materials. For preventing degradation of SiC/SiC, environmental barrier coatings (EBC) for ceramics are deposited on the composites. The purpose of this study is to establish theoretical guidelines for structural design which ensures the mechanical reliability of EBC. We conducted finite element method (FEM) analysis to calculate energy release rates (ERRs) for interface crack initiation due to thermal stress in EBC consisting of Si-based bond coat, Mullite and Ytterbium (Yb)-silicate layers on a SiC/SiC substrate. In the FEM analysis, the thickness of one EBC layer was changed from 25 μm to 200 μm while the thicknesses of the other layers were fixed at 25 μm, 50 μm and 100 μm. We compared ERRs obtained by the FEM analysis and a simple theory for interface crack in a single-layered structure where ERR is estimated as nominal strain energy in the coating layers multiplied by a constant factor (independent of layer thicknesses). We found that, unlike the case of single-layered structures, the multiplication factor is no longer a constant but is determined by the combination of consisting coating layer thicknesses.


    郭茂林; 孟庆元; 王彪


    A new extrapolation approach was proposed to calculate the strain energy release rates of complex cracks. The point-by-point closed method was used to calculate the closed energy, thus the disadvantage of self inconsistency in some published papers can be avoided. The disadvantage is that the closed energy is repeatedly calculated: when closed nodal number along radial direction is more than two, the displacement of nodes behind the crack tip that is multiplied by nodal forces, the closed energy has been calculated and the crack surfaces have been closed, and that closed energy of middle point is calculated repeatedly. A DCB ( double cantilever beam) specimen was calculated and compared with other theoretical results, it is shown that a better coincidence is obtained. In addition the same results are also obtained for compact tension specimen, three point bend specimen and single edge cracked specinen. In comparison with theoretical results, the error can be limited within 1 per cent. This method can be extended to analyze the fracture of composite laminates with various delamination cracks.

  9. Measurement Uncertainty of Chromogenic LAL Assays: Reaction Time and Proportion of Endotoxin and LAL Reagent Affect Release of p-Nitroaniline.

    Ostronoff, Celina Silva; Lourenço, Felipe Rebello


    Limulus Amebocyte Lysate (LAL) assays are widely used for detection and quantification of bacterial endotoxins in pharmaceuticals and medical devices. However, there are only a few studies on the measurement uncertainty of LAL assays. The aim of this work was to identify and quantify the main sources of measurement uncertainty for end point and kinetic-chromogenic LAL assays. Response surface methodology was used to study how the release of p-nitroaniline (pNA) is affected by reaction time and proportion of endotoxin and LAL reagent in end point and kinetic-chromogenic LAL assays, respectively. Increased release of pNA was observed when reaction time was increased. In addition, if different volumes of sample (or endotoxin standard) and LAL reagent are used, the pNA release rate will be affected. These results may be due to the increased interaction between the bacterial endotoxin and LAL-activated enzyme. Final measurement uncertainties (95% confidence interval) were 90-120% and 90-127% of bacterial endotoxin content for end point and kinetic-chromogenic assays, respectively. These values are reasonable for the scope of the method and allow the application of these measurement uncertainties in routine analysis of pharmaceuticals and medical devices.


    TangShengdao; WangFengquan


    To solve a real problem :how to calculate the reliability of a system with time-varying failure rates in industry systems,this paper studies a model for the load-sharing parallel system with time-varying failure rates,and obtains calculating formulas of reliability and availability of the system by solving differential equations. In this paper, the failure rates are expressed in polynomial configuration. The constant,linear and Weibull failure rate are in their special form. The polynomial failure rates provide flexibility in modeling the practical time-varying failure rates.

  11. Comparison of release rates of ibuprofen sustained-release capsules from different manufacturers%不同厂家布洛芬缓释胶囊体外释放度比较

    彭秋燕; 许煜静; 许文婷; 李翔宇; 杨金荣


    目的:考察9个不同厂家的布洛芬缓释胶囊的体外释放度并与芬必得缓释胶囊进行对比,为临床合理用药提供参考.方法:按照《中华人民共和国药典》2010年版有关布洛芬缓释胶囊释放度测定的规定,采用转篮法的装置进行体外溶出实验,用高效液相色谱法进行含量测定,计算累积释放百分率,进行释药曲线拟合,比较溶出参数,并通过计算相似因子的方法与芬必得进行比较.结果:9个厂家中仅F厂的产品释放不符合要求,其余厂家产品释放度均符合要求,且与芬必得缓释胶囊相似因子大于50.除F厂家外,其余厂家产品的释药曲线均符合威布尔方程.结论:不同厂家产品存在内在差异,可为临床用药提供参考.%Objective: To investigate the release rates of different ibuprofen sustained-release capsules in vitro by comparing with fen-bid, thus provide a reference for its rational use in clinical. Methods: The release rate tests of ibuprofen sustained-release capsules were performed accordance to China Pharmacopeia (2010 edition, basket-rotating method of drug release rate), and the release amount was determined by HPLC. Release curve was used to fit different equation, and the parameters of m, T50 and Td were caculated and compared with fenbid. f2 factor was calculated to compare their similarity with fenbid. Results: The f2 factors of nine manufacturers' products with fenbid were greater than 50, except for F capsule. And their release curves are fit with Weibull equation. Conclusion: There are differences in dissolution parameters among the ibuprofen sustained-release capsules from different manufacturers.

  12. Timing of pollen release and stigma receptivity period of Piper vicosanum: New insights into sexual reproduction of the genus.

    Valentin-Silva, Adriano; Coelho, Victor Peçanha de Miranda; Ventrella, Marília Contin; Vieira, Milene Faria


    Dichogamy is a common characteristic among angiosperms, including Piper species. In this genus, the tiny flowers are morphologically similar and have an asynchronous stamen development. However, there is no information on the duration of stigma receptivity and whether it overlaps with pollen release. To better understand mechanisms of floral function in Piper vicosanum, we provide a detailed characterization of the timing of pollen release from the four stamens and the period of stigma receptivity and exposure mode of the receptive areas. We investigated plants of a natural population in a semideciduous seasonal forest (Viçosa, Minas Gerais State, southeastern Brazil), based on chemical tests, light microscopy, and scanning electron microscopy analyses. Incomplete protogyny-a mechanism that favors outcrossing-was recorded. The period of stigma receptivity was long (14 d), and the sequential exposure and senescence of stigmatic papillae occurred gradually and in a basipetal direction. Pollen release began 2-6 d after the beginning of the pistillate phase, with an average pollen viability of 87.7%, during the bisexual flower phase. Pollen was released for up to 6 d and occurred in one stamen at a time. The fruit set observed in tests of self-pollination indicated self-compatibility. The gradual and sequential exposure of stigmatic papillae in P. vicosanum flowers is described here as the mechanism for the long duration of receptivity. Anther development and pollen release were also sequential. These findings are yet unreported reproductive characteristics of the genus and offer new perspectives for future studies on the floral biology of other Piper species. © 2015 Botanical Society of America, Inc.

  13. Effect of timing of estradiol benzoate administration upon synchronization of ovulation in suckling Nelore cows (Bos indicus) treated with a progesterone-releasing intravaginal device.

    Ayres, H; Martins, C M; Ferreira, R M; Mello, J E; Dominguez, J H; Souza, A H; Valentin, R; Santos, I C C; Baruselli, P S


    The present study investigated how the timing of the administration of estradiol benzoate (EB) impacted the synchronization of ovulation in fixed-time artificial insemination protocols of cattle. To accomplish this, two experiments were conducted, with EB injection occurring at different times: at withdrawal of the progesterone-releasing (P4) intravaginal device or 24h later. The effectiveness of these times was compared by examining ovarian follicular dynamics (Experiment 1, n=30) and conception rates (Experiment 2, n=504). In Experiment 1, follicular dynamics was performed in 30 Nelore cows (Bos indicus) allocated into two groups. On a random day of the estrous cycle (Day 0), both groups received 2mg of EB i.m. and a P4-releasing intravaginal device, which was removed on Day 8, when 400 IU of eCG and 150 microg of PGF were administered. The control group (G-EB9; n=15) received 1mg of EB on Day 9, while Group EB8 (G-EB8; n=15) received the same dose a day earlier. Ovarian ultrasonographic evaluations were performed every 8h after device removal until ovulation. The timing of EB administration (Day 8 compared with Day 9) did affect the interval between P4 device removal to ovulation (59.4+/-2.0 h compared with 69.3+/-1.7h) and maximum diameter of dominant (1.54+/-0.06 acm compared with 1.71+/-0.05 bcm, P=0.03) and ovulatory (1.46+/-0.05 acm compared with 1.58+/-0.04 bcm, Pwithdrawal (D8), the interval to ovulation shortened and dominant and ovulatory follicle diameters decreased. Furthermore, when EB treatment was performed 24h after device removal, FTAI conducted at either 48 or 54 h resulted in similar conception rates. However, EB treatment on the same day as device withdrawal resulted in a lesser conception rate when FTAI was conducted 54 h after device removal.

  14. Study on detection method of niacin release rate in lovastatin and niacin ustained-release tablets%洛伐他汀烟酸缓释片中烟酸释放度检测方法研究

    蒋艳霞; 秦晶晶; 焦志斌


    目的 建立洛伐他汀烟酸缓释片中烟酸释放度的最佳检测方法.方法 参照ADVICOR中烟酸释放度测定方法,将水做为释放介质,温度(37±0.5)℃,转速为100 r/min,作为本实验中烟酸的释放条件;照中紫外-可见分光光度法(2010版附录Ⅳ A),选用262 nm作为烟酸溶出量紫外检测波长.结果 烟酸的溶出量不受辅料影响;浓度在11.01-27.13 μg/ml范围内回收率大于99.70%;体外24 h内烟酸的稳定性良好;在3.88-23.28 μg/ml浓度范围内,紫外吸光度与溶液浓度呈良好的线性关系;烟酸释放均一性没有显著差异.结论 此方法适合洛伐他汀烟酸缓释片中烟酸释放度的测定.%Objective To establish an optimal detection method of niacin in lovastatin and niacin sustained-release tablets. Methods Referring to the detection method of the release rate of niacin in ADVICOR(R) , niacin release conditions were as follows: water as the release medium,( 37 ±0.5 )℃ ,100 r/min. According to UV-Vis spectrophotometry in Chinese Pharmacopoeia( 2010 version of Appendix ⅣA ) , niacin detection wavelength was set at 262 nm. Results Niacin release rate was not affected by the excipients. Recovery rate was more than 99. 70% at the concentrations of 11.01- 27. 13 μg/ml. Nician stability in vitro was good in 24 h. It showed a good linear relationship between UV absorbance and the solution concentration in the range of 3. 88 - 23. 28 μg/ml. Niacin release homogeneity was not significantly different. Conclusion This method is suitable for detecting the niacin release rate in lovastatin and niacin sustained-release tablets.

  15. An optimal policy for deteriorating items with time-proportional deterioration rate and constant and time-dependent linear demand rate

    Singh, Trailokyanath; Mishra, Pandit Jagatananda; Pattanayak, Hadibandhu


    In this paper, an economic order quantity (EOQ) inventory model for a deteriorating item is developed with the following characteristics: (i) The demand rate is deterministic and two-staged, i.e., it is constant in first part of the cycle and linear function of time in the second part. (ii) Deterioration rate is time-proportional. (iii) Shortages are not allowed to occur. The optimal cycle time and the optimal order quantity have been derived by minimizing the total average cost. A simple solution procedure is provided to illustrate the proposed model. The article concludes with a numerical example and sensitivity analysis of various parameters as illustrations of the theoretical results.

  16. Release of a single neurotransmitter from an identified interneuron coherently affects motor output on multiple time scales

    Dacks, Andrew M.; Weiss, Klaudiusz R.


    Neurotransmitters can have diverse effects that occur over multiple time scales often making the consequences of neurotransmission difficult to predict. To explore the consequences of this diversity, we used the buccal ganglion of Aplysia to examine the effects of GABA release by a single interneuron, B40, on the intrinsic properties and motor output of the radula closure neuron B8. B40 induces a picrotoxin-sensitive fast IPSP lasting milliseconds in B8 and a slow EPSP lasting seconds. We fou...

  17. Effect of hearing aid release time and presentation level on speech perception in noise in elderly individuals with hearing loss.

    Pottackal Mathai, Jijo; Mohammed, Hasheem


    To investigate the effect of compression time settings and presentation levels on speech perception in noise for elderly individuals with hearing loss. To compare aided speech perception performance in these individuals with age-matched normal hearing subjects. Twenty (normal hearing) participants within the age range of 60-68 years and 20 (mild-to-moderate sensorineural hearing loss) in the age range of 60-70 years were randomly recruited for the study. In the former group, SNR-50 was determined using phonetically balanced sentences that were mixed with speech-shaped noise presented at the most comfortable level. In the SNHL group, aided SNR-50 was determined at three different presentation levels (40, 60, and 80 dB HL) after fitting binaural hearing aids that had different compression time settings (fast and slow). In the SNHL group, slow compression time settings showed significantly better SNR-50 compared to fast release time. In addition, the mean of SNR-50 in the SNHL group was comparable to normal hearing participants while using a slow release time. A hearing aid with slow compression time settings led to significantly better speech perception in noise, compared to that of a hearing aid that had fast compression time settings.

  18. Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation.

    Tan, David Cheng Thiam; Chin, William Wei Lim; Tan, En Hui; Hong, Shiqi; Gu, Wei; Gokhale, Rajeev


    Conventional manufacturing of pharmaceutical tablets often involves single processes such as blending, granulation, milling and direct compression. A process that minimizes and incorporates all these in a single continuous step is desirable. The concept of omitting milling step followed by direct-molding of tablets utilizing a twin-screw extruder in a melt granulation process using thermoplastic binders was explored. The objective of this study was to investigate the effect of combining hydrophilic binder (HPMC K4M, PEO 1M), and hydrophobic binder (Compritol® ATO 888, Precirol® ATO 5) on the release profiles of direct-molded tablets and direct-compressed tablets from milled extrudates using a quality-by-design approach. It was identified that hydrophilic binder type and process significantly affects (p=0.005) the release profiles of verapamil. Moreover, two-way interaction analysis demonstrated that the combination of process with type of hydrophilic polymer (p=0.028) and the type of hydrophilic polymer with polymer ratio (p=0.033) significantly affected the release profiles. The formulation release kinetics correlated to Higuchi release model and the mechanism correlated to a non-Fickian release mechanism. The results of the present study indicated that direct-molded tablets with different release profiles can be manufactured without milling process and through a continuous melt granulation using twin-screw extruder with appropriate thermoplastic binder ratio.

  19. Development and Design of Cost-Effective, Real-Time Implementable Sediment and Contaminant Release Controls

    Hampson, Steve [Univ of KY, Center for Applied Energy Research, Kentucky Research Consortium for Energy and Environment


    evaporation –only and evapotranspiration – infiltration secondary treatment methods. Based on a 5 acre site and a very conservative evapotranspiration rate, i.e. a low value of 0.10 in/day, a completely full Pond 015 would take approximately 10 days to empty by the drip irrigation system design. For a 25 acre site, the dewatering time would, of course, be 2 days. For the micro-sprinkler irrigation system 8 and 1 ¾ days would be required for the 5 acre and 25 acre sites, respectively. When the evapotranspiration – infiltration treatment system was employed the drip irrigation system, based on a 5 acre site, would take 2 days to dewatering Pond 015; 1/10 of the evapotranspiration-only method. For the micro-sprinklers, with a 5 acre site the dewatering time would be 1 ¾ days. A comprehensive irrigation design was completed for each alternative scenario and a listing of all major system components was provided. Outfall 008 was used to illustrate the combination weep berm – grass filter treatment system. Such a system has proven to be very effective at other applied research and at international hard rock mines. Design considerations were provided encompassing dewatering pumping rate, sediment load and concentration, soil type, weep berm characteristics and grass filter length and infiltration rates. The expected performance of a combination weep berm – grass filter system design was illustrated through a detailed example and SEDCAD modeling. The retention pond – weep berm – grass filter, for the illustrated example, resulted in a peak effluent sediment concentration at the end of the grass filter of 2 mg

  20. Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate.

    Guilfoyle, Amy P; Deshpande, Chandrika N; Vincent, Kimberley; Pedroso, Marcelo M; Schenk, Gerhard; Maher, Megan J; Jormakka, Mika


    GTPases (G proteins) hydrolyze the conversion of GTP to GDP and free phosphate, comprising an integral part of prokaryotic and eukaryotic signaling, protein biosynthesis and cell division, as well as membrane transport processes. The G protein cycle is brought to a halt after GTP hydrolysis, and requires the release of GDP before a new cycle can be initiated. For eukaryotic heterotrimeric Gαβγ proteins, the interaction with a membrane-bound G protein-coupled receptor catalyzes the release of GDP from the Gα subunit. Structural and functional studies have implicated one of the nucleotide binding sequence motifs, the G5 motif, as playing an integral part in this release mechanism. Indeed, a Gαs G5 mutant (A366S) was shown to have an accelerated GDP release rate, mimicking a G protein-coupled receptor catalyzed release state. In the present study, we investigate the role of the equivalent residue in the G5 motif (residue A143) in the prokaryotic membrane protein FeoB from Streptococcus thermophilus, which includes an N-terminal soluble G protein domain. The structure of this domain has previously been determined in the apo and GDP-bound states and in the presence of a transition state analogue, revealing conformational changes in the G5 motif. The A143 residue was mutated to a serine and analyzed with respect to changes in GTPase activity, nucleotide release rate, GDP affinity and structural alterations. We conclude that the identity of the residue at this position in the G5 loop plays a key role in the nucleotide release rate by allowing the correct positioning and hydrogen bonding of the nucleotide base. © 2014 FEBS.

  1. Real-time imaging of ATP release induced by mechanical stretch in human airway smooth muscle cells.

    Takahara, Norihiro; Ito, Satoru; Furuya, Kishio; Naruse, Keiji; Aso, Hiromichi; Kondo, Masashi; Sokabe, Masahiro; Hasegawa, Yoshinori


    Airway smooth muscle (ASM) cells within the airway walls are continually exposed to mechanical stimuli, and exhibit various functions in response to these mechanical stresses. ATP acts as an extracellular mediator in the airway. Moreover, extracellular ATP is considered to play an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease. However, it is not known whether ASM cells are cellular sources of ATP secretion in the airway. We therefore investigated whether mechanical stretch induces ATP release from ASM cells. Mechanical stretch was applied to primary human ASM cells cultured on a silicone chamber coated with type I collagen using a stretching apparatus. Concentrations of ATP in cell culture supernatants measured by luciferin-luciferase bioluminescence were significantly elevated by cyclic stretch (12 and 20% strain). We further visualized the stretch-induced ATP release from the cells in real time using a luminescence imaging system, while acquiring differential interference contrast cell images with infrared optics. Immediately after a single uniaxial stretch for 1 second, strong ATP signals were produced by a certain population of cells and spread to surrounding spaces. The cyclic stretch-induced ATP release was significantly reduced by inhibitors of Ca(2+)-dependent vesicular exocytosis, 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetraacetoxymethyl ester, monensin, N-ethylmaleimide, and bafilomycin. In contrast, the stretch-induced ATP release was not inhibited by a hemichannel blocker, carbenoxolone, or blockade of transient receptor potential vanilloid 4 by short interfering RNA transfection or ruthenium red. These findings reveal a novel property of ASM cells: mechanically induced ATP release may be a cellular source of ATP in the airway.

  2. A Real-Time Terahertz Time-Domain Polarization Analyzer with 80-MHz Repetition-Rate Femtosecond Laser Pulses

    Takehiro Tachizaki


    Full Text Available We have developed a real-time terahertz time-domain polarization analyzer by using 80-MHz repetition-rate femtosecond laser pulses. Our technique is based on the spinning electro-optic sensor method, which we recently proposed and demonstrated by using a regenerative amplifier laser system; here we improve the detection scheme in order to be able to use it with a femtosecond laser oscillator with laser pulses of a much higher repetition rate. This improvement brings great advantages for realizing broadband, compact and stable real-time terahertz time-domain polarization measurement systems for scientific and industrial applications.

  3. A real-time terahertz time-domain polarization analyzer with 80-MHz repetition-rate femtosecond laser pulses.

    Watanabe, Shinichi; Yasumatsu, Naoya; Oguchi, Kenichi; Takeda, Masatoshi; Suzuki, Takeshi; Tachizaki, Takehiro


    We have developed a real-time terahertz time-domain polarization analyzer by using 80-MHz repetition-rate femtosecond laser pulses. Our technique is based on the spinning electro-optic sensor method, which we recently proposed and demonstrated by using a regenerative amplifier laser system; here we improve the detection scheme in order to be able to use it with a femtosecond laser oscillator with laser pulses of a much higher repetition rate. This improvement brings great advantages for realizing broadband, compact and stable real-time terahertz time-domain polarization measurement systems for scientific and industrial applications.

  4. Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment.

    Park, Chan Woo; Choi, Min Hye; Yang, Kwang Moon; Song, In Ok


    To determine the preferred regimen for women with adenomyosis undergoing in vitro fertilization (IVF), we compared the IVF outcomes of fresh embryo transfer (ET) cycles with or without gonadotropin-releasing hormone (GnRH) agonist pretreatment and of frozen-thawed embryo transfer (FET) cycles following GnRH agonist treatment. This retrospective study included 241 IVF cycles of women with adenomyosis from January 2006 to January 2012. Fresh ET cycles without (147 cycles, group A) or with (105 cycles, group B) GnRH agonist pretreatment, and FET cycles following GnRH agonist treatment (43 cycles, group C) were compared. Adenomyosis was identified by using transvaginal ultrasound at the initial workup and classified into focal and diffuse types. The IVF outcomes were also subanalyzed according to the adenomyotic region. GnRH agonist pretreatment increased the stimulation duration (11.5±2.1 days vs. 9.9±2.0 days) and total dose of gonadotropin (3,421±1,141 IU vs. 2,588±1,192 IU), which resulted in a significantly higher number of retrieved oocytes (10.0±8.2 vs. 7.9±6.8, p=0.013) in group B than in group A. Controlled ovarian stimulation for freezing resulted in a significantly higher number of retrieved oocytes (14.3±9.2 vs. 10.0±8.2, p=0.022) with a lower dose of gonadotropin (2,974±1,112 IU vs. 3,421±1,141 IU, p=0.037) in group C than in group B. The clinical pregnancy rate in group C (39.5%) tended to be higher than those in groups B (30.5%) and A (25.2%) but without a significant difference. FET following GnRH agonist pretreatment tended to increase the pregnancy rate in patients with adenomyosis. Further large-scale prospective studies are required to confirm this result.

  5. Preparation of Ibuprofen Sustained-release Tablet and Its Release Rate in Vitro%布洛芬缓释片的制备及其体外释放度考察

    王平; 肖昌录; 袁训贤


    OBJECTIVE: To study and prepare Ibuprofen sustained-release tablets and to establish determination method for release rate of it in vitro. METHODS: Ibuprofen sustained-release tablet was prepared using hydrophilic gel framework material. The content of Ibuprofen sustained release tablets was determined by HPLC. Ac coding to stirring basket method stated in Chinese Pharmacopeia (2010 edition), phosphate buffer solution was used as solvent at rotating speed of 150 r·min-1 to determine release rate of 3 batches of samples in vitro. Repeatability of different batches and homogeneity of the same batch of samples (1, 3, 6, 8 h)were investigated. RESULTS: 3 batches of sustained-release tablet released completely within 8 h with sound repeatability. The RSDs of dissolution rate of the same batch of samples at 1, 3, 6, 8 h were 0.45%, 1.89%, 1.88%, 1.31%. There was small difference among different batches. CONCLUSION: Established preparation method is simple and stable, and the method for in vitro dissolution rate determination is convenient, rapid and easy to do.%目的:研制布洛芬缓释片并建立其体外释放度测定方法.方法:以亲水性凝胶骨架材料羟丙基甲基纤维素制备布洛芬缓释片.采用高效液相色谱法测定其含量,根据2010年版篮法,以磷酸盐缓冲液为溶出介质、转速为150 r·min-1测定3批样品的体外释放度,进行批闻重现性和同一批样品的均一性(1、3、6、8h)考察.结果:所制3批缓释片在8 h内释放基本完成,批间重现性良好;同一批样品在1、3、6、8 h各取样时间点,释放度的RSD值分别为0.45%、1.89%、1.88%、1.3l%,批间差异小.结论:布洛芬缓释片的制备方法简单、质量稳定,建立的体外释放度测定方法简便、快速,易于操作.

  6. Reconciling extreme branch length differences: decoupling time and rate through the evolutionary history of filmy ferns.

    Schuettpelz, Eric; Pryer, Kathleen M


    The rate of molecular evolution is not constant across the Tree of Life. Characterizing rate discrepancies and evaluating the relative roles of time and rate along branches through the past are both critical to a full understanding of evolutionary history. In this study, we explore the interactions of time and rate in filmy ferns (Hymenophyllaceae), a lineage with extreme branch length differences between the two major clades. We test for the presence of significant rate discrepancies within and between these clades, and we separate time and rate across the filmy fern phylogeny to simultaneously yield an evolutionary time scale of filmy fern diversification and reconstructions of ancestral rates of molecular evolution. Our results indicate that the branch length disparity observed between the major lineages of filmy ferns is indeed due to a significant difference in molecular evolutionary rate. The estimation of divergence times reveals that the timing of crown group diversification was not concurrent for the two lineages, and the reconstruction of ancestral rates of molecular evolution points to a substantial rate deceleration in one of the clades. Further analysis suggests that this may be due to a genome-wide deceleration in the rate of nucleotide substitution.

  7. Formulation of a modified release metformin. HCl matrix tablet: influence of some hydrophilic polymers on release rate and in-vitro evaluation

    John Rojas


    Full Text Available Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic polymers that rendered a 24 h in-vitro release profile of metformin.HCl. The Korsmeyer-Peppas model was used to model the dissolution profiles since it presented the best fit to the experimental data. Further, a cubic model predicted the best formulation of metformin.HCl containing polyvinyl pyrrolidone, ethyl cellulose, hydroxypropyl methyl cellulose, carrageenan, sodium alginate, and gum arabic at 6.26, 68.7, 6.26, 6.26, 6.26 and 6.26 % levels, respectively. The validation runs confirmed the accuracy of the cubic model with six components for predicting the best set of components which rendered a once-a-day modified release hydrophilic matrix tablet in compliance with the USP specifications.O cloridrato de metformina é um agente antidiabético que melhora a tolerância à glicose em pacientes com diabetes tipo 2 e reduz os níveis plasmáticos basais de glicose. Neste estudo, um projeto experimental do tipo "centróide simplex" com 69 tomadas foi usado para selecionar a melhor combinação de alguns polímeros hidrofílicos que gerou um perfil de liberação da metformina.HCl de 24 horas. O modelo Korsmeyer-Peppas foi usado para modelar os perfis de dissolução, uma vez que apresentou os melhores ajustes aos dados experimentais. Além disso, um modelo cúbico previu a melhor formulação de metformina.HCl sendo aquela contendo polivinilpirrolidona, etilcelulose, hidroxipropilmetil celulose, carragena, alginato de sódio e goma arábica nos níveis 6.26, 68.7, 6.26, 6.26, 6.26 e 6.26 %, respectivamente. As corridas de validação confirmaram a precisão do modelo cúbico com os seis componentes para prever o melhor conjunto de componentes que originou uma

  8. Hurdle Effect of Antimicrobial Activity Achieved by Time Differential Releasing of Nisin and Chitosan Hydrolysates from Bacterial Cellulose.

    Hsiao, Hui-Ling; Lin, Shih-Bin; Chen, Li-Chen; Chen, Hui-Huang


    We investigated the combined antimicrobial effect of nisin and chitosan hydrolysates (CHs) by regulating the antimicrobial reaction order of substances due to differential releasing rate from hydroxypropylmethylcellulose-modified bacterial cellulose (HBC). The minimum inhibitory concentration of nisin against Staphylococcus aureus and that of CHs against Escherichia coli were 6 IU and 200 μg/mL, respectively. Hurdle and additive effects in antimicrobial tests were observed when nisin was used 6 h before CH treatment against S. aureus; similar effects were observed when CH was used before nisin treatment against E. coli. Simultaneously combined treatment of nisin and CHs exhibited the low antimicrobial effect. HBC was then selected as the carrier for the controlled release of nisin and CHs. A 90% inhibition in the growth of S. aureus and E. coli was achieved when 30 IU-nisin-containing HBC and 62.5 μg/mL-CH-containing HBC were used simultaneously. The controlled release of nisin and CHs by using HBC minimized the interaction between nisin and CHs as well as increased the number of microbial targets.

  9. Effect of adding self-emulsifying excipients on release rate of tetramethylpyrazine-release solid dispersion%自乳化辅料对川芎嗪缓释固体分散体释放度的影响

    王利胜; 陈晓丹; 吕耿彬; 涂星; 吴俊洪


    Objective: To determine the effect of adding self-emulsifying excipients on release rate of tetramethylpyrazine-release solid dispersion (TMP-SD).Methods: The in vitro dissolution between TMP-SD and tetramethylpyrazine-release self-emulsifying solid dispersion (TMP-SESD) was compared.Results: The cumulative release rate of TMP-SD was (39.26±1.86)% within 12 h, whereas that of TMP-SESD was (98.33 ± 2.02)% .Conclusion: Addition of self-emulsifying excipients to the TMP-SD can greatly increase the drug release rate.%目的:考察自乳化辅料的加入对川芎嗪缓释固体分散体释放度的影响,为剂型的改进提供一定的依据.方法:HPLC法测定川芎嗪缓释固体分散体(tetramethylpyrazine solid dispersion,TMP-SD)与川芎嗪自乳化缓释固体分散体(tetramethylpyrazine self-emulsifying solid dispersion,TMP-SESD)的累积释放度,比较二者的释药特征.结果:TMP-SD 12 h释放量仅为(39.26±1.86)%,而TMP-SESD释放量可达(98.33±2.02)%.结论:自乳化辅料的加入解决了TMP-SD释放度过低的问题,达到理想的释药效果.

  10. Photovoltaic Capacity Additions: The optimal rate of deployment with sensitivity to time-based GHG emissions

    Triplican Ravikumar, Dwarakanath

    Current policies subsidizing or accelerating deployment of photovoltaics (PV) are typically motivated by claims of environmental benefit, such as the reduction of CO2 emissions generated by the fossil-fuel fired power plants that PV is intended to displace. Existing practice is to assess these environmental benefits on a net life-cycle basis, where CO2 benefits occurring during use of the PV panels is found to exceed emissions generated during the PV manufacturing phase including materials extraction and manufacture of the PV panels prior to installation. However, this approach neglects to recognize that the environmental costs of CO2 release during manufacture are incurred early, while environmental benefits accrue later. Thus, where specific policy targets suggest meeting CO2 reduction targets established by a certain date, rapid PV deployment may have counter-intuitive, albeit temporary, undesired consequences. Thus, on a cumulative radiative forcing (CRF) basis, the environmental improvements attributable to PV might be realized much later than is currently understood. This phenomenon is particularly acute when PV manufacture occurs in areas using CO2 intensive energy sources (e.g., coal), but deployment occurs in areas with less CO 2 intensive electricity sources (e.g., hydro). This thesis builds a dynamic Cumulative Radiative Forcing (CRF) model to examine the inter-temporal warming impacts of PV deployments in three locations: California, Wyoming and Arizona. The model includes the following factors that impact CRF: PV deployment rate, choice of PV technology, pace of PV technology improvements, and CO2 intensity in the electricity mix at manufacturing and deployment locations. Wyoming and California show the highest and lowest CRF benefits as they have the most and least CO2 intensive grids, respectively. CRF payback times are longer than CO2 payback times in all cases. Thin film, CdTe PV technologies have the lowest manufacturing CO2 emissions and

  11. The rating of perceived exertion during competitive running scales with time.

    Faulkner, James; Parfitt, Gaynor; Eston, Roger


    This study assessed the relationship of the rating of perceived exertion (RPE) with heart rate and pacing strategy during competitive running races of differing distance and course elevation. Nine men and women competed in a 7-mile road race (7-MR) and the Great West Run half marathon (GWR; 13.1 miles). Heart rate, split mile time, and RPE were recorded throughout the races. The RPE was regressed against time and %time to complete the 7-MR and GWR. Although the rate of increase in RPE was greater in the 7-MR, there were no differences when expressed against %time (inferring that the brain uses a scalar timing mechanism). As the course elevation, distance, pacing strategy, and heart rate response varied between conditions, this study has provided evidence that the perceptual response may have distinct temporal characteristics during distance running. The results provide further evidence that RPE scales with the proportion of exercise time that remains.

  12. Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization

    M. L. Gomez


    Full Text Available The influence of the ionic character of a specific drug on its release rate from a hydrogel based on 2-hydroxyethylmethacrylate (HEMA and acrylamide (AAm is analyzed. The hydrogel was synthesized by photopolymerization employing visible light, safranine O (Saf, as sensitizer, and a silsesquioxane functionalized with amine and methacrylate groups (SFMA, as co-initiator and crosslinker. Safranine O (Saf was employed as a model of a cationic drug and the anionic form of resorufin (Rf as a model of an anionic drug. Saf exhibited a larger affinity with functional groups of the hydrogel than that of Rf. This produced a lower loading and a faster release rate of Rf with respect to Saf. Besides, the release rate of Rf followed a Fickian behavior, while that of Saf exhibited a non-Fickian behavior. By hydrolyzing the hydrogel at pH = 13, amide groups supplied by AAm were irreversibly converted into carboxylic acid groups. Higher loadings and slower release rates of Saf from the hydrolyzed hydrogels were observed, making them particularly suitable for the slow drug-delivery of cationic drugs.


    Wu Gang; Chen Ming; Wang Haifeng; Cheng Shixin


    Space-time trellis codes can achieve the best tradeoff among bandwidth effciency,diversity gain, constellation size and trellis complexity. In this paper, some optimum low rate space-time trellis codes are proposed. Performance analysis and simulation show that the low rate space-time trellis codes outperform space-time block codes concatenated with convolutional code at the same bandwidth effciency, and are more suitable for the power limited wireless communication system.

  14. Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release

    Chartoff, Elena H; Ebner, Shayla R; Sparrow, Angela; Potter, David; Baker, Phillip M; Ragozzino, Michael E; Roitman, Mitchell F


    Negative affective states can increase the rewarding value of drugs of abuse and promote drug taking. Chronic cocaine exposure increases levels of the neuropeptide dynorphin, an endogenous ligand at kappa opioid receptors (KOR) that suppresses dopamine release in the nucleus accumbens (NAc) and elicits negative affective states upon drug withdrawal. However, there is evidence that the effects of KOR activation on affective state are biphasic: immediate aversive effects are followed by delayed increases in reward. The impact of KOR-induced affective states on reward-related effects of cocaine over time is not known. We hypothesize that the initial aversive effects of KOR activation increase, whereas the delayed rewarding effects decrease, the net effects of cocaine on reward and dopamine release. We treated rats with cocaine at various times (15 min to 48 h) after administration of the selective KOR agonist salvinorin A (salvA). Using intracranial self-stimulation and fast scan cyclic voltammetry, we found that cocaine-induced increases in brain stimulation reward and evoked dopamine release in the NAc core were potentiated when cocaine was administered within 1 h of salvA, but attenuated when administered 24 h after salvA. Quantitative real-time PCR was used to show that KOR and prodynorphin mRNA levels were decreased in the NAc, whereas tyrosine hydroxylase and dopamine transporter mRNA levels and tissue dopamine content were increased in the ventral tegmental area 24 h post-salvA. These findings raise the possibility that KOR activation—as occurs upon withdrawal from chronic cocaine—modulates vulnerability to cocaine in a time-dependent manner. PMID:26239494

  15. Dynamics of a Hogg-Huberman Model with Time Dependent Reevaluation Rates

    Tanaka, Toshijiro; Kurihara, Tetsuya; Inoue, Masayoshi


    The dynamical behavior of the Hogg-Huberman model with time-dependent reevaluation rates is studied. The time dependence of the reevaluation rate that agents using one of resources decide to consider their resource choice is obtained in terms of states of the system. It is seen that the change of fraction of agents using one resource is suppressed to be smaller than that in the case of a fixed reevaluation rate and the chaos control in the system associated with time-dependent reevaluation rates can be performed by the system itself.

  16. Differential Dropout Rates of Minority and Majority Job Candidates Due to "Time Lags" between Selection Procedures

    Arvey, Richard D.; And Others


    This research investigated whether or not "time lags" are related to the dropout rates of job applicants. The effect of duration of these time lags, periods between initial job application and psychological testing, on differential dropout rates of minority and majority candidates was also examined. (Author/RK)

  17. Convergence Rate for Discrete-Time Multiagent Systems With Time-Varying Delays and General Coupling Coefficients.

    Chen, Yao; Ho, Daniel W C; Lü, Jinhu; Lin, Zongli


    Multiagent systems (MASs) are ubiquitous in our real world. There is an increasing attention focusing on the consensus (or synchronization) problem of MASs over the past decade. Although there are numerous results reported on the convergence of a discrete-time MAS based on the infinite products of matrices, few results are on the convergence rate. Because of the switching topology, the traditional eigenvalue analysis and the Lyapunov function methods are both invalid for the convergence rate analysis of an MAS with a switching topology. Therefore, the estimation of the convergence rate for a discrete-time MAS with time-varying delays remains a difficult problem. To overcome the essential difficulty of switching topology, this paper aims at developing a contractive-set approach to analyze the convergence rate of a discrete-time MAS in the presence of time-varying delays and generalized coupling coefficients. Using the proposed approach, we obtain an upper bound of the convergence rate under the condition of joint connectivity. In particular, the proposed method neither requires the nonnegative property of the coupling coefficients nor the basic assumption of a uniform lower bound for all positive coupling coefficients, which have been widely applied in the existing works on this topic. As an application of the main results, we will show that the classical Vicsek model with time delays can realize synchronization if the initial topology is connected.

  18. Real-Time Fluorescence Tracking of Protoporphyrin Incorporated Thermosensitive Hydrogel and Its Drug Release in Vivo.

    Dong, Xia; Wei, Chang; Liu, Tianjun; Lv, Feng; Qian, Zhiyong


    Fluorescence imaging in vivo will pave an important way for the evaluation of biomaterials. The major advantage of fluorescence imaging compared to other imaging modalities is the possibility of tracking two or more fluorescence probes simultaneously with multispectral fluorescence imaging. It is essential to elucidate the location, erosion, drug release and resection of implanted biomaterials in vivo. Herein, a thermosensitive hydrogel with a protoporphyrin core based on a PEG and PCL copolymer (PCL-PEG-PPOR-PEG-PCL) was synthesized by ring-opening polymerization using protoporphyrin as a fluorescence tag. The optical properties of the hydrogel were investigated by UV-vis and fluorescence spectroscopy in vitro and by fluorescence imaging system in vivo. The hydrogel erosion and drug delivery in vivo were monitored and tracked by multispectral fluorescence imaging system in nude mice. The results show that the thermosensitive hydrogel exhibits fluorescence and injectability in vivo with good biocompatibility. Through the modality of fluorescence imaging, the status of the hydrogel is reflected in situ in vivo including its location and erosion. Multispectral analysis separates the autofluorescence signals from the specific label and provides the ability to locate the drug and carrier. The protoporphyrin incorporated thermosensitive hydrogel can be a potential visiable biomedical implant for tissue repair or drug delivery.

  19. Note: A high count rate real-time digital processing method for PGNAA data acquisition system

    Liu, Yuzhe; Chen, Lian; Li, Feng; Liang, Futian; Jin, Ge


    The prompt gamma neutron activation analysis (PGNAA) technique is a real-time online method to analyze the composition of industrial materials. This paper presents a data acquisition system with a high count rate and real-time digital processing method for PGNAA. Limited by the decay time of the detector, the ORTEC multi-channel analyzer (MCA) can normally achieve an average count rate of 100 kcps. However, this system uses an electrical technique to increase the average count rate and reduce dead time, and guarantees good accuracy. Since the measuring time is usually limited to about 120 s, in order to accelerate the accumulation rate of spectrum and reduce the statistical error, the average count rate is expected to reach more than 500 kcps.

  20. Time-dependent release of growth factors from implant surfaces treated with plasma rich in growth factors.

    Sánchez-Ilárduya, María Belén; Trouche, Elodie; Tejero, Ricardo; Orive, Gorka; Reviakine, Ilya; Anitua, Eduardo


    Plasma rich in growth factors (PRGFs) technology is an autologous platelet-rich plasma approach that provides a pool of growth factors and cytokines that have been shown to increase tissue regeneration and accelerate dental implant osseointegration. In this framework, the spatiotemporal release of growth factors and the establishment of a provisional fibrin matrix are likely to be key aspects governing the stimulation of the early phases of tissue regeneration around implants. We investigated the kinetics of growth factor release at implant surfaces functionalized either with PRGFs or platelet-poor plasma and correlated the results obtained with the morphology of the resulting interfaces. Our main finding is that activation and clot formation favors longer residence times of the growth factors at the interfaces studied, probably due to their retention in the adsorbed fibrin matrix. The concentration of the platelet-derived growth factors above the interfaces becomes negligible after 2-4 days and is significantly higher in the case of activated interfaces than in the case of nonactivated ones, whereas that of the plasmatic hepatocyte growth factor is independent of platelet concentration and activation, and remains significant for up to 9 days. Platelet-rich plasma preparations should be activated to permit growth factor release and thereby facilitate implant surface osseointegration.

  1. Poly(ethylene glycol)-poly(lactic-co-glycolic acid) core-shell microspheres with enhanced controllability of drug encapsulation and release rate.

    Cha, Chaenyung; Jeong, Jae Hyun; Kong, Hyunjoon


    Poly(lactic-co-glycolic acid) (PLGA) microspheres have been widely used as drug carriers for minimally invasive, local, and sustained drug delivery. However, their use is often plagued by limited controllability of encapsulation efficiency, initial burst, and release rate of drug molecules, which cause unsatisfactory outcomes and several side effects including inflammation. This study presents a new strategy of tuning the encapsulation efficiency and the release rate of protein drugs from a PLGA microsphere by filling the hollow core of the microsphere with poly(ethylene glycol) (PEG) hydrogels of varying cross-linking density. The PEG gel cores were prepared by inducing in situ cross-linking reactions of PEG monoacrylate solution within the PLGA microspheres. The resulting PEG-PLGA core-shell microspheres exhibited (1) increased encapsulation efficiency, (2) decreased initial burst, and (3) a more sustained release of protein drugs, as the cross-linking density of the PEG gel core was increased. In addition, implantation of PEG-PLGA core-shell microspheres encapsulated with vascular endothelial growth factor (VEGF) onto a chicken chorioallantoic membrane resulted in a significant increase in the number of new blood vessels at an implantation site, while minimizing inflammation. Overall, this strategy of introducing PEG gel into PLGA microspheres will be highly useful in tuning release rates and ultimately in improving the therapeutic efficacy of a wide array of protein drugs.

  2. A GTPase chimera illustrates an uncoupled nucleotide affinity and release rate, Providing insight into the activation mechanism

    Guilfoyle, Amy P.; Deshpande, Chandrika N.; Font Sadurni, Josep;


    The release of GDP from GTPases signals the initiation of a GTPase cycle, where the association of GTP triggers conformational changes promoting binding of downstream effector molecules. Studies have implicated the nucleotide-binding G5 loop to be involved in the GDP release mechanism. For example......, biophysical studies on both the eukaryotic Gα proteins and the GTPase domain (NFeoB) of prokaryotic FeoB proteins have revealed conformational changes in the G5 loop that accompany nucleotide binding and release. However, it is unclear whether this conformational change in the G5 loop is a prerequisite...... GTPase activity at a similar level to wild-type NFeoB, and structural analyses of the nucleotide-free and GDP-bound proteins show that the G5 loop adopts conformations analogous to that of the human nucleotide-bound Giα1 protein in both states. Interestingly, isothermal titration calorimetry and stopped...

  3. Short-term Outcomes following Concussion in the NFL: An 11-year Retrospective Study of Player Release Rate and Financial Loss

    Ramkumar, Prem; Navarro, Sergio Michael


    Objectives: The primary goal of this study was to assess the short-term outcomes among National Football League (NFL) players following concussion in terms of: (1) DNP protocol activation, (2) release rate at one and three years, and (3) mean salary reduction. A secondary goal of the study was to stratify the post-concussive release rate by franchise and player position. Methods: NFL player transaction records and publicly available weekly injury reports from August 2005 to January 2016 for NFL players were analyzed. All players immediately sustaining recorded concussions were evaluated for a change to inactive or do-not-play (DNP) status. The one-year and three-year release rate following concussion was defined as any player transitioning to inactivation, retirement, free agency, or any failure to return for a successive season on the same team’s active roster after one or three years from the initial concussion. Student’s t-test was used to compare release rates between non-concussed and concussed players at one and three years. Mean salary reduction per year following concussion was calculated using publicly available player contracts. Additionally, franchise-level and position-based analyses of the release rate were performed. Results: Of the total 5,451 NFL players retrospectively analyzed over the 11-year period, 373 sustained publicly reported concussions resulting in DNP protocol activation. The release rate of the post-concussive versus non-concussive player was 26% vs. 20% at 1 year (p<0.01) and 31% vs. 19% at 3 years (p<0.01). After analyzing individual player contracts, the mean year-over-year change in contract value for concussed players after DNP protocol activation was an overall salary reduction of $760,000/year ± $2,380,000. Figure 1 depicts the tendency of each NFL franchise to release an athlete following concussion within one and three years. Table 1 reports a position-based analysis in terms of concussion rate, mean salary reduction, and

  4. The effect of treatment with a slow-releasing oxytocin preparation at the onset of oestrus on the ovulation rate of Merino ewes : research note

    P.R. King


    Full Text Available The effect of a slow-releasing oxytocin preparation on the ovulation rate of Merino ewes was investigated. Synchronised Merino ewes were subcutaneously injected with a slow-re-leasing preparation containing 10 IU oxytocin, 48 hours after sponge withdrawal. Laparo-scopic examination of the ovaries of all ewes was performed 10 d after the oxytocin treatment in order to determine the number of corpora lutea per ewe. The ovulation rate of the adult ewes of the treated and control groups was 179.1 % and 159.1 % respectively (p < 0.05 while that of the 2-tooth ewes was 108.3 % and 112.8 % respectively (p > 0.05. It would appear that a higher ovulation rate can be obtained by a single injection of a slow-releasing oxytocin preparation at the onset of oestrus. The lack of response in the 2-tooth ewes was probably due to their relatively low body weight.

  5. Optimal harvesting of fish stocks under a time-varying discount rate

    Duncan, Stephen; Hepburn, Cameron; Papachristodoulou, Antonis


    Abstract Optimal control theory has been extensively used to determine the optimal harvesting policy for renewable resources such as fish stocks. In such optimizations, it is common to maximise the discounted utility of harvesting over time, employing a constant time discount rate. However, evidence from human and animal behaviour suggests that we have evolved to employ discount rates which fall over time, often referred to as ?hyperbolic discounting?. This increases the weight on ...


    白翠莲; 孙虹; 许丽萍


    Objective:To prepare ibuprofen sustained-release pellets. Methods:Blank cores were prepared by means of powder layering with the PDL-Ⅱequipment,ibuprofen pellets were coated in the same equipment. Various factors influence on release rate and the release mechanism of the drug from the pellets was studied. Results:The optimal formula of the ibuprofen sustained release pellets were the following:pill core 100g,ibuprofen 300g,stearic acid 3g,PVP K 306g,and the dissolution test in vitro showed that they can meet with ibuprofen sustained release capsules launched. Release mechanism of the drug from pellets was in accordance with Higuchi equation:Q=-14. 814+38. 480t1/2(r=0. 996). Conclusions:The method and the formulation are successful in providing slow and steady release of ibuprofen from sustained-release pellets.%目的::制备布洛芬缓释微丸。方法:采用DPL-Ⅱ多功能制粒包衣机制备微晶纤维素空白丸芯和布洛芬含药微丸。用释放度测定法考察影响药物释放的各种因素,并对布洛芬缓释微丸体外释药机理进行研究。结果:布洛芬缓释微丸最佳处方为:丸芯100g、布洛芬300g、硬脂酸3g、PVP K 306 g,其释放度与市售产品(芬必得)拟合良好,体外释药过程基本符合Higuchi 方程:Q=-14.814+38.480t1/2(r=0.996)。结论:成功的制备了布洛芬缓释微丸。

  7. Real-Time Measurement of Volatile Chemicals Released by Bed Bugs during Mating Activities

    Kilpinen, Ole Østerlund; Liu, Dezhao; Adamsen, Anders Peter


    In recent years, bed bug (Hemiptera: Cimicidae) problems have increased dramatically in many parts of the world, leading to a renewed interest in their chemical ecology. Most studies of bed bug semiochemicals have been based on the collection of volatiles over a period of time followed by chemical...... analysis. Here we present for the first time, a combination of proton transfer reaction mass spectrometry and video analysis for real-time measurement of semiochemicals emitted by isolated groups of bed bugs during specific behavioural activities. The most distinct peaks in the proton transfer reaction...... mass spectrometry recordings were always observed close to the termination of mating attempts, corresponding to the defensive emissions that bed bugs have been suspected to exploit for prevention of unwanted copulations. The main components of these emissions were (E)-2-hexenal and (E)-2-octenal...

  8. Application of sonication to release DNA from Bacillus cereus for quantitative detection by real-time PCR.

    Fykse, Else Marie; Olsen, Jaran Strand; Skogan, Gunnar


    A rapid sonication method for lysis of Gram-positive bacteria was evaluated for use in combination with quantitative real-time polymerase chain reaction (PCR) analyses for detection. Other criteria used for evaluation of lysis were microscopic cell count, colony forming units (cfu), optical density at 600 nm and total yield of DNA measured by PicoGreen fluorescence. The aim of this study was complete disruption of cellular structures and release of DNA without the need for lysing reagents and time-consuming sample preparation. The Gram-positive bacterium Bacillus cereus was used as a model organism for Gram-positive bacteria. It was demonstrated by real-time PCR that maximum yield of DNA was obtained after 3 to 5 min of sonication. The yield of DNA was affected by culture age and the cells from a 4-h-old culture in the exponential phase of growth gave a higher yield of DNA after 5 min of sonication than a 24-h-old culture in the stationary phase of growth. The 4-h-old culture was also more sensitive for lysis caused by heating. The maximum yield of DNA, evaluated by real-time PCR, from a culture of the Gram-negative bacterium Escherichia coli, was obtained after 20 s of sonication. However, the yield of target DNA from E. coli rapidly decreased after 50 s of sonication due to degradation of DNA. Plate counting (cfu), microscopic counting and absorbance at 600 nm showed that the number of viable and structurally intact B. cereus cells decreased rapidly with sonication time, whereas the yield of DNA increased as shown by PicoGreen fluorescence and real-time PCR. The present results indicate that 3-5 min of sonication is sufficient for lysis and release of DNA from samples of Gram-positive bacteria.

  9. Evaluation of Gamma Fluence Rate Predictions for 41-argon Releases to the Atmosphere at a Nuclear Research Reactor Site

    Rojas-Palma, Carlos; Aage, Helle Karina; Astrup, Poul


    An experimental study of radionuclide dispersion in the atmosphere has been conducted at the BR1 research reactor in Mol, Belgium. Artificially generated aerosols ('white smoke') were mixed with the routine releases of Ar-41 in the reactor's 60-m tall venting stack. The detailed plume geometry...

  10. Unexpectedly high catch-and-release rates in European marine recreational fisheries: implications for science and management

    Ferter, K.; Weltersbach, M.S.; Strehlow, H.V.; Graaf, de M.; Hammen, van der T.


    While catch-and-release (C&R) is a well-known practice in several European freshwater recreational fisheries, studies on the magnitude and impact of this practice in European marine recreational fisheries are limited. To provide an overview of the practice and magnitude of C&R among marine

  11. Evaluation of Gamma Fluence Rate Predictions for 41-argon Releases to the Atmosphere at a Nuclear Research Reactor Site

    Rojas-Palma, Carlos; Aage, Helle Karina; Astrup, Poul


    An experimental study of radionuclide dispersion in the atmosphere has been conducted at the BR1 research reactor in Mol, Belgium. Artificially generated aerosols ('white smoke') were mixed with the routine releases of Ar-41 in the reactor's 60-m tall venting stack. The detailed plume geometry...

  12. It's about time: WHO and partners release programming strategies for postpartum family planning.

    Gaffield, Mary Eluned; Egan, Shannon; Temmerman, Marleen


    The postpartum period is a critical time to address high unmet family planning need and to reduce the risks of closely spaced pregnancies. Practical tools are included in the new resource for integrating postpartum family planning at points when women have frequent health system contact, including during antenatal care, labor and delivery, postnatal care, immunization, and child health care.

  13. Real-Time Measurement of Volatile Chemicals Released by Bed Bugs during Mating Activities

    Kilpinen, Ole Østerlund; Liu, Dezhao; Adamsen, Anders Peter


    In recent years, bed bug (Hemiptera: Cimicidae) problems have increased dramatically in many parts of the world, leading to a renewed interest in their chemical ecology. Most studies of bed bug semiochemicals have been based on the collection of volatiles over a period of time followed by chemical...

  14. 3D time-dependent flow computations using a molecular stress function model with constraint release

    Rasmussen, Henrik Koblitz


    The numerical simulation of time dependent viscoelastic flow (in three dimensions) is of interest in connection with a variety of polymer processing operations. The application of the numerical simulation techniques is in the analysis and design of polymer processing problems. This is operations,...

  15. Sudden cold temperature regulates the time-lag between plant CO2 uptake and release

    Barthel, M.; Cieraad, E.; Zakharova, A.; Hunt, J. E.


    Since substrates for respiration are supplied mainly by recent photo-assimilates, there is a strong but time-lagged link between short-term above- and belowground carbon (C) cycling. However, regulation of this coupling by environmental variables is poorly understood. Whereas recent studies focussed on the effect of drought and shading on the link between above and belowground short-term C cycling, the effect of temperature remains unclear. We used a 13CO2 pulse-chase labelling experiment to investigate the effect of a sudden temperature change from 25 °C to 10 °C on the short-term coupling between assimilatory C uptake and respiratory loss. The study was done in the laboratory using two month old perennial rye-grass plants (time intervals using laser spectroscopy. In addition, δ13C was also analysed in bulk root and shoot samples using IRMS. Cold temperature (10 °C) reduced the short-term coupling between shoot and roots by delaying belowground transfer of recent assimilates and its subsequent respiratory use, as indicated by the δ13C signal of root respiration (δ13CRR). That is, the time-lag from the actual shoot labelling to the first appearance of the label in 13CRR was about 1.5 times longer under cold temperature (time-lags of 1 h and 1.5 h in the warm and cold treatments, respectively). Moreover, analysis of bulk shoot and root material revealed that plants at cold temperature invest relatively more carbon into respiration compared to growth or storage. These results increase our understanding of environmental controls on the link between short-term above- and belowground C cycling.

  16. In vitro release testing of matrices based on starch-methyl methacrylate copolymers: effect of tablet crushing force, dissolution medium pH and stirring rate.

    Ferrero, C; Jiménez-Castellanos, M R


    Direct-compressed matrix tablets were obtained from a variety of potato starch-methyl methacrylate copolymers(1) as sustained-release agents, using anhydrous theophylline as a model drug. The aim of this work was to investigate the influence of the copolymer type, the tablet crushing force and dissolution variables such as the pH of the dissolution medium and the agitation intensity on the in vitro drug release behaviour of such matrices. Commercial sustained-release theophylline products (Theo-Dur(®) 100mg, Theolair(®) 175 mg) were used as standards. Test formulations were compacted into tablets at three different crushing force ranges (70-80, 90-100 and 110-120 N) to examine the effect of this factor on the porous network and drug release kinetics. In vitro release experiments were conducted in a pH-changing medium (1.2-7.5) with basket rotation speeds in the range 25-100 r.p.m. to simulate the physiological conditions of the gastrointestinal tract. The release rate of theophylline was practically not affected by pH in the case of Theo-Dur(®) and HSMMA matrices. In contrast, Theolair(®) and CSMMA tablets demonstrated a biphasic drug release pattern, which appeared to be sensitive to the pH of the dissolution medium. An increase in the crushing force of the copolymer matrices was accompanied by a reduction of the matrix porosity, although the porous network depends markedly on the type of copolymer, having a strong influence on the drug release kinetics. Mathematical modelling of release data shows a Fickian diffusion or anomalous transport mechanism. Based on the similarity factor f2, FD-HSMMA, OD-CSMMA and FD-CSMMA at 90-100 N were selected for agitation studies. In general, all formulations showed an agitation speed-dependent release, with Theo-Dur(®) and FD-CSMMA matrices being the less susceptible to this factor. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. Morning employees are perceived as better employees: employees' start times influence supervisor performance ratings.

    Yam, Kai Chi; Fehr, Ryan; Barnes, Christopher M


    In this research, we draw from the stereotyping literature to suggest that supervisor ratings of job performance are affected by employees' start times-the time of day they first arrive at work. Even when accounting for total work hours, objective job performance, and employees' self-ratings of conscientiousness, we find that a later start time leads supervisors to perceive employees as less conscientious. These perceptions in turn cause supervisors to rate employees as lower performers. In addition, we show that supervisor chronotype acts as a boundary condition of the mediated model. Supervisors who prefer eveningness (i.e., owls) are less likely to hold negative stereotypes of employees with late start times than supervisors who prefer morningness (i.e., larks). Taken together, our results suggest that supervisor ratings of job performance are susceptible to stereotypic beliefs based on employees' start times. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  18. Pneumatic shutoff and time-delay valve operates at controlled rate

    Horning, J. L.; Tomlinson, L. E.


    Shutoff and time delay valve, which incorporates a metering spool that moves at constant velocity under pneumatic pressure and spring compression, increases fluid-flow area at a uniform rate. Diaphragm areas, control cavity volume, and bleed-orifice size may be varied to give any desired combination of time delay and spool travel time.

  19. Use of age-adjusted rates of suicide in time series studies in Israel.

    Bridges, F Stephen; Tankersley, William B


    Durkheim's modified theory of suicide was examined to explore how consistent it was in predicting Israeli rates of suicide from 1965 to 1997 when using age-adjusted rates rather than crude ones. In this time-series study, Israeli male and female rates of suicide increased and decreased, respectively, between 1965 and 1997. Conforming to Durkheim's modified theory, the Israeli male rate of suicide was lower in years when rates of marriage and birth are higher, while rates of suicide are higher in years when rates of divorce are higher, the opposite to that of Israeli women. The corrected regression coefficients suggest that the Israeli female rate of suicide remained lower in years when rate of divorce is higher, again the opposite suggested by Durkheim's modified theory. These results may indicate that divorce affects the mental health of Israeli women as suggested by their lower rate of suicide. Perhaps the "multiple roles held by Israeli females creates suicidogenic stress" and divorce provides some sense of stress relief, mentally speaking. The results were not as consistent with predictions suggested by Durkheim's modified theory of suicide as were rates from the United States for the same period nor were they consistent with rates based on "crude" suicide data. Thus, using age-adjusted rates of suicide had an influence on the prediction of the Israeli rate of suicide during this period.

  20. Location and release time identification of pollution point source in river networks based on the Backward Probability Method.

    Ghane, Alireza; Mazaheri, Mehdi; Mohammad Vali Samani, Jamal


    The pollution of rivers due to accidental spills is a major threat to environment and human health. To protect river systems from accidental spills, it is essential to introduce a reliable tool for identification process. Backward Probability Method (BPM) is one of the most recommended tools that is able to introduce information related to the prior location and the release time of the pollution. This method was originally developed and employed in groundwater pollution source identification problems. One of the objectives of this study is to apply this method in identifying the pollution source location and release time in surface waters, mainly in rivers. To accomplish this task, a numerical model is developed based on the adjoint analysis. Then the developed model is verified using analytical solution and some real data. The second objective of this study is to extend the method to pollution source identification in river networks. In this regard, a hypothetical test case is considered. In the later simulations, all of the suspected points are identified, using only one backward simulation. The results demonstrated that all suspected points, determined by the BPM could be a possible pollution source. The proposed approach is accurate and computationally efficient and does not need any simplification in river geometry and flow. Due to this simplicity, it is highly recommended for practical purposes. Copyright © 2016. Published by Elsevier Ltd.

  1. Flow Time Analysis of Load Management Late Arrival Discrete Time Queueing System with Dual Service Rate Using Hypogeometrical Distribution

    Syed Asif Ali Shah


    Full Text Available Flow time analysis is a powerful concept to analyze the flow time of any arriving customer in any system at any instant. A load management mechanism can be employed very effectively in any queueing system by utilizing a system which provides probability of dual service rate. In this paper, we develop and demonstrate the flow and service processes transition diagram to determine the flow time of a customer in a load management late arrival state dependent finite discrete time queueing system with dual service rate where customers are hypogeometrically distributed. We compute the probability mass function of each starting state and total probability mass function. The obtained analytical results are validated with simulation results for varying values of arrival and service probabilities.

  2. Daylight savings time transitions and the incidence rate of unipolar depressive episodes

    Hansen, Bertel T; Sønderskov, Kim M; Hageman, Ida


    BACKGROUND: Daylight savings time transitions affect approximately 1.6 billion people worldwide. Prior studies have documented associations between daylight savings time transitions and adverse health outcomes, but it remains unknown whether they also cause an increase in the incidence rate...... of depressive episodes. This seems likely because daylight savings time transitions affect circadian rhythms, which are implicated in the etiology of depressive disorder. Therefore, we investigated the effects of daylight savings time transitions on the incidence rate of unipolar depressive episodes. METHODS......: Using time series intervention analysis of nationwide data from the Danish Psychiatric Central Research Register from 1995 to 2012 we compared the observed trend in the incidence rate of hospital contacts for unipolar depressive episodes after the transitions to and from summer time to the predicted...

  3. A fluid response: Alpha-amylase reactions to acute laboratory stress are related to sample timing and saliva flow rate.

    Nagy, Tamás; van Lien, René; Willemsen, Gonneke; Proctor, Gordon; Efting, Marieke; Fülöp, Márta; Bárdos, György; Veerman, Enno C I; Bosch, Jos A


    Salivary alpha-amylase (sAA) is used as a sympathetic (SNS) stress marker, though its release is likely co-determined by SNS and parasympathetic (PNS) activation. The SNS and PNS show asynchronous changes during acute stressors, and sAA responses may thus vary with sample timing. Thirty-four participants underwent an eight-minute memory task (MT) and cold pressor task (CPT). Cardiovascular SNS (pre-ejection period, blood pressure) and PNS (heart rate variability) activity were monitored continuously. Unstimulated saliva was collected repeatedly during and after each laboratory stressor, and sAA concentration (U/ml) and secretion (U/minute) determined. Both stressors increased anxiety. The MT caused an immediate and continued cardiac SNS activation, but sAA concentration increased at task cessation only (+54%); i.e., when there was SNS-PNS co-activation. During the MT sAA secretion even decreased (-35%) in conjunction with flow rate and vagal tone. The CPT robustly increased blood pressure but not sAA. In summary, sAA fluctuations did not parallel changes in cardiac SNS activity or anxiety. sAA responses seem contingent on sample timing and flow rate, likely involving both SNS and PNS influences. Verification using other stressors and contexts seems warranted.

  4. Low-sampling-rate ultra-wideband digital receiver using equivalent-time sampling

    Ballal, Tarig


    In this paper, we propose an all-digital scheme for ultra-wideband symbol detection. In the proposed scheme, the received symbols are sampled many times below the Nyquist rate. It is shown that when the number of symbol repetitions, P, is co-prime with the symbol duration given in Nyquist samples, the receiver can sample the received data P times below the Nyquist rate, without loss of fidelity. The proposed scheme is applied to perform channel estimation and binary pulse position modulation (BPPM) detection. Results are presented for two receivers operating at two different sampling rates that are 10 and 20 times below the Nyquist rate. The feasibility of the proposed scheme is demonstrated in different scenarios, with reasonable bit error rates obtained in most of the cases.

  5. "The End of Time" released - a film partly shot at CERN


    Qu’est-ce que le temps ? Une réalité ? Une illusion ? Un concept ? Ces questions sont au coeur du nouveau film de Peter Mettler. Avec The End of Time, guidé par son intuition et sa capacité d’émerveillement, Peter Mettler projette à nouveau le familier dans une dimension extraordinaire et nous donne à voir l’invisible.   Dix ans après Gambling, gods and LSD, son prodigieux essai visuel sur la transcendance, Peter Mettler revient avec un film d’une profonde et rare beauté. Troisième opus d’une trilogie commencée avec Picture of light (1996), puis Gambling, gods and LSD (2002), The End of Time confirme l'attachement de Mettler à un cinéma exigeant, résolument virtuose et visionnaire. Synopsis : Défi envers l’insaisissable sujet du temps entre le dicible et l’...

  6. Sparse Bayesian learning machine for real-time management of reservoir releases

    Khalil, Abedalrazq; McKee, Mac; Kemblowski, Mariush; Asefa, Tirusew


    Water scarcity and uncertainties in forecasting future water availabilities present serious problems for basin-scale water management. These problems create a need for intelligent prediction models that learn and adapt to their environment in order to provide water managers with decision-relevant information related to the operation of river systems. This manuscript presents examples of state-of-the-art techniques for forecasting that combine excellent generalization properties and sparse representation within a Bayesian paradigm. The techniques are demonstrated as decision tools to enhance real-time water management. A relevance vector machine, which is a probabilistic model, has been used in an online fashion to provide confident forecasts given knowledge of some state and exogenous conditions. In practical applications, online algorithms should recognize changes in the input space and account for drift in system behavior. Support vectors machines lend themselves particularly well to the detection of drift and hence to the initiation of adaptation in response to a recognized shift in system structure. The resulting model will normally have a structure and parameterization that suits the information content of the available data. The utility and practicality of this proposed approach have been demonstrated with an application in a real case study involving real-time operation of a reservoir in a river basin in southern Utah.

  7. A New High Rate Differential Space-Time-Frequency Modulation for MIMO-OFDM


    In this paper, we propose a new differential space-time-frequency (DSTF) modulation for MIMO- OFDM system with four transmit-antennas and arbitrary receive-antennas, which can improve the transmission rate since it can adopt high order quadrature amplitude modulation (QAM) modulation. Our proposed DSTF scheme embeds some full diversity full rate (FDFR) quasi-orthogonal space-time codes (QOSTBC) with QAM modulation into the frequency intervals and adopts the differential modulation in both time and frequency domains. The simulation results demonstrate that the proposed DSTF scheme can improve transmission rate greatly. Compared with the conventional differential unitary space-time modulation (DUSTM), it can get better transmission performance in high transmission rate for MIMO-OFDM system.

  8. Neutron Scattering in Hydrogenous Moderators, Studied by Time Dependent Reaction Rate Method

    Larsson, L.G.; Moeller, E.; Purohit, S.N.


    The moderation and absorption of a neutron burst in water, poisoned with the non-1/v absorbers cadmium and gadolinium, has been followed on the time scale by multigroup calculations, using scattering kernels for the proton gas and the Nelkin model. The time dependent reaction rate curves for each absorber display clear differences for the two models, and the separation between the curves does not depend much on the absorber concentration. An experimental method for the measurement of infinite medium reaction rate curves in a limited geometry has been investigated. This method makes the measurement of the time dependent reaction rate generally useful for thermalization studies in a small geometry of a liquid hydrogenous moderator, provided that the experiment is coupled to programs for the calculation of scattering kernels and time dependent neutron spectra. Good agreement has been found between the reaction rate curve, measured with cadmium in water, and a calculated curve, where the Haywood kernel has been used.

  9. Hydrogen release from sodium alanate observed by time-resolved neutron backscattering.

    Léon, Aline; Wuttke, Joachim


    Innermolecular motion in Na(3)AlH(6) gives rise to a Lorentzian spectrum with a wavenumber-independent width of about 1  µeV at 180 °C, which is probably due to the rotation of AlH(6) tetrahedra. There is no such quasielastic line in NaAlH(4) or NaH. Based on this finding, time-resolved measurements on the neutron backscattering spectrometer SPHERES were used to monitor the decomposition kinetics of sodium alanate, [Formula: see text] NaH. Both reaction steps were found to be accelerated by autocatalysis, most likely at the surfaces of Na(3)AlH(6) and NaH crystallites.

  10. Hydrogen release from sodium alanate observed by time-resolved neutron backscattering

    Leon, Aline [Karlsruhe Institute of Technology, Institute of Nanotechnology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Wuttke, Joachim, E-mail:, E-mail: [Juelich Centre for Neutron Science JCNS, Forschungszentrum Juelich GmbH, Outstation at FRM II, Lichtenbergstrasse 1, 85747 Garching (Germany)


    Innermolecular motion in Na{sub 3}AlH{sub 6} gives rise to a Lorentzian spectrum with a wavenumber-independent width of about 1 {mu}eV at 180 {sup 0}C, which is probably due to the rotation of AlH{sub 6} tetrahedra. There is no such quasielastic line in NaAlH{sub 4} or NaH. Based on this finding, time-resolved measurements on the neutron backscattering spectrometer SPHERES were used to monitor the decomposition kinetics of sodium alanate, NaAlH{sub 4{yields}}Na{sub 3}AlH{sub 6{yields}} NaH. Both reaction steps were found to be accelerated by autocatalysis, most likely at the surfaces of Na{sub 3}AlH{sub 6} and NaH crystallites.

  11. Diastolic time – frequency relation in the stress echo lab: filling timing and flow at different heart rates

    Faita Francesco


    Full Text Available Abstract A cutaneous force-frequency relation recording system based on first heart sound amplitude vibrations has been recently validated. Second heart sound can be simultaneously recorded in order to quantify both systole and diastole duration. Aims 1- To assess the feasibility and extra-value of operator-independent, force sensor-based, diastolic time recording during stress. Methods We enrolled 161 patients referred for stress echocardiography (exercise 115, dipyridamole 40, pacing 6 patients. The sensor was fastened in the precordial region by a standard ECG electrode. The acceleration signal was converted into digital and recorded together with ECG signal. Both systolic and diastolic times were acquired continuously during stress and were displayed by plotting times vs. heart rate. Diastolic filling rate was calculated as echo-measured mitral filling volume/sensor-monitored diastolic time. Results Diastolic time decreased during stress more markedly than systolic time. At peak stress 62 of the 161 pts showed reversal of the systolic/diastolic ratio with the duration of systole longer than diastole. In the exercise group, at 100 bpm HR, systolic/diastolic time ratio was lower in the 17 controls (0.74 ± 0.12 than in patients (0.86 ± 0.10, p Diastolic filling rate increased from 101 ± 36 (rest to 219 ± 92 ml/m2* s-1 at peak stress (p Conclusion Cardiological systolic and diastolic duration can be monitored during stress by using an acceleration force sensor. Simultaneous calculation of stroke volume allows monitoring diastolic filling rate. Stress-induced "systolic-diastolic mismatch" can be easily quantified and is associated to several cardiac diseases, possibly expanding the spectrum of information obtainable during stress.

  12. Generation time, net reproductive rate, and growth in stage-age-structured populations

    Steiner, Uli; Tuljapurkar, Shripad; Coulson, Tim


    to age-structured populations. Here we generalize this result to populations structured by stage and age by providing a new, unique measure of reproductive timing (Tc) that, along with net reproductive rate (R0), has a direct mathematical relationship to and approximates growth rate (r). We use simple...

  13. Application of time-hopping UWB range-bit rate performance in the UWB sensor networks

    Nascimento, J.R.V. do; Nikookar, H.


    In this paper, the achievable range-bit rate performance is evaluated for Time-Hopping (TH) UWB networks complying with the FCC outdoor emission limits in the presence of Multiple Access Interference (MAI). Application of TH-UWB range-bit rate performance is presented for UWB sensor networks. Result

  14. Research on Mail Surveys: Response Rates and Methods in Relation to Population Group and Time.

    Boser, Judith A.; Green, Kathy

    The purpose of this review was to look for trends across time in response rates and variables studied for published mail surveys and to compare response rates and variables studied for different target populations. Studies were identified in databases in four fields: education, psychology, business and marketing, and sociology. A total of 225…

  15. Space-time evolution rules of acoustic emission location of unloaded coal sample at different loading rates

    Ai Ting; Zhang Ru; Liu Jianfeng; Ren Li


    By using MTS815 rock mechanics test system,a series of acoustic emission (AE) location experiments were performed under unloading confining pressure,increasing the axial stress.The AE space-time evolution regularities and energy releasing characteristics during deformation and failure process of coal of different loading rates are compared,the influence mechanism of loading rates on the microscopic crack evolution were studied,combining the AE characteristics and the macroscopic failure modes of the specimens,and the precursory characteristics of coal failure were also analyzed quantitatively.The results indicate that as the loading rate is higher,the AE activity and the main fracture will begin earlier.The destruction of coal body is mainly the function of shear strain at lower loading rate and tension strain at higher rate,and will transform from brittleness to ductility at critical velocities.When the deformation of the coal is mainly plasticity,the amplitude of the AE tinging counting rate increases largely and the AE energy curves appear an obvious "step",which can be defined as the first failure precursor point.Statics of AE information shows that the strongest AE activity begins when the axial stress level was 92-98%,which can be defined as the other failure precursor point.As the loading rate is smaller,the coal more easily reaches the latter precursor point after the first one,so attention should be aroused to prevent dynamic disaster in coal mining when the AE activity reaches the first precursor point.

  16. Space-time evolution rules of acoustic emission location of unloaded coal sample at different loading rates

    Ai; Ting; Zhang; Ru; Liu; Jianfeng; Ren; Li


    By using MTS815 rock mechanics test system,a series of acoustic emission(AE) location experiments were performed under unloading confining pressure,increasing the axial stress.The AE space-time evolution regularities and energy releasing characteristics during deformation and failure process of coal of different loading rates are compared,the influence mechanism of loading rates on the microscopic crack evolution were studied,combining the AE characteristics and the macroscopic failure modes of the specimens,and the precursory characteristics of coal failure were also analyzed quantitatively.The results indicate that as the loading rate is higher,the AE activity and the main fracture will begin earlier.The destruction of coal body is mainly the function of shear strain at lower loading rate and tension strain at higher rate,and will transform from brittleness to ductility at critical velocities.When the deformation of the coal is mainly plasticity,the amplitude of the AE ringing counting rate increases largely and the AE energy curves appear an obvious ''step'',which can be defined as the first failure precursor point.Statics of AE information shows that the strongest AE activity begins when the axial stress level was 92-98%,which can be defined as the other failure precursor point.As the loading rate is smaller,the coal more easily reaches the latter precursor point after the first one,so attention should be aroused to prevent dynamic disaster in coal mining when the AE activity reaches the first precursor point.

  17. Variable responses by southern pine beetle, Dendroctonus frontalis Zimmermann, to the pheromone component endo-brevicomin: influence of enantiomeric composition, release rate, and proximity to infestations.

    Sullivan, Brian T; Dalusky, Mark J; Mori, Kenji; Brownie, Cavell


    The male-produced bicyclic acetal endo-brevicomin is a component of the pheromone blend that mediates colonization of host pines by the bark beetle Dendroctonus frontalis Zimmermann. Efforts to identify its behavioral function have been complicated by contrasting reports that it either enhances or reduces attraction of flying beetles. Our studies failed to support the hypothesis that this published variability is due to differences in release rate and/or the enantiomeric composition [i.e., the beetle-produced (+)-enantiomer vs. the racemate] of the endo-brevicomin used in the experiments. In trapping trials within active D. frontalis infestations, racemic and (+)-endo-brevicomin did not differ from each other in behavioral effects when tested at seven different release rates ranging from 0.005 to 3 mg/d. At the highest release rates, racemic and (+)-endo-brevicomin similarly reduced catches in traps baited with an attractant (frontalin and turpentine), but neither enhanced catches at any release rate. Furthermore, the activity of racemic endo-brevicomin baits depended on trap proximity to D. frontalis infestations. Addition of these baits to attractant-baited traps located inside active infestations reduced catches, but they enhanced catches at traps located either 100 or 200 m outside these infestations. The contrasting responses may reflect differences in host-seeking strategies by either aggregated or dispersing D. frontalis, and may be elicited by differing abundance of natural sources of semiochemicals or differing responsiveness of beetles inside vs. outside of infestations. We suspect that much of the published variability in D. frontalis responses to endo-brevicomin is attributable to differing proximity of experimental field sites to infestations.

  18. GNSS seismometer: Seismic phase recognition of real-time high-rate GNSS deformation waves

    Nie, Zhaosheng; Zhang, Rui; Liu, Gang; Jia, Zhige; Wang, Dijin; Zhou, Yu; Lin, Mu


    High-rate global navigation satellite systems (GNSS) can potentially be used as seismometers to capture short-period instantaneous dynamic deformation waves from earthquakes. However, the performance and seismic phase recognition of the GNSS seismometer in the real-time mode, which plays an important role in GNSS seismology, are still uncertain. By comparing the results of accuracy and precision of the real-time solution using a shake table test, we found real-time solutions to be consistent with post-processing solutions and independent of sampling rate. In addition, we analyzed the time series of real-time solutions for shake table tests and recent large earthquakes. The results demonstrated that high-rate GNSS have the ability to retrieve most types of seismic waves, including P-, S-, Love, and Rayleigh waves. The main factor limiting its performance in recording seismic phases is the widely used 1-Hz sampling rate. The noise floor also makes recognition of some weak seismic phases difficult. We concluded that the propagation velocities and path of seismic waves, macro characteristics of the high-rate GNSS array, spatial traces of seismic phases, and incorporation of seismographs are all useful in helping to retrieve seismic phases from the high-rate GNSS time series.

  19. Release the BEESTS: Bayesian Estimation of Ex-Gaussian STop-Signal Reaction Time Distributions

    Dora eMatzke


    Full Text Available The stop-signal paradigm is frequently used to study response inhibition. Inthis paradigm, participants perform a two-choice response time task wherethe primary task is occasionally interrupted by a stop-signal that promptsparticipants to withhold their response. The primary goal is to estimatethe latency of the unobservable stop response (stop signal reaction timeor SSRT. Recently, Matzke, Dolan, Logan, Brown, and Wagenmakers (inpress have developed a Bayesian parametric approach that allows for theestimation of the entire distribution of SSRTs. The Bayesian parametricapproach assumes that SSRTs are ex-Gaussian distributed and uses Markovchain Monte Carlo sampling to estimate the parameters of the SSRT distri-bution. Here we present an efficient and user-friendly software implementa-tion of the Bayesian parametric approach —BEESTS— that can be appliedto individual as well as hierarchical stop-signal data. BEESTS comes withan easy-to-use graphical user interface and provides users with summarystatistics of the posterior distribution of the parameters as well various diag-nostic tools to assess the quality of the parameter estimates. The softwareis open source and runs on Windows and OS X operating systems. In sum,BEESTS allows experimental and clinical psychologists to estimate entiredistributions of SSRTs and hence facilitates the more rigorous analysis ofstop-signal data.

  20. Time-stretched real-time measurement technique for ultrafast absorption variations with TS/s sampling-rate.

    Weber, Stefan; Waller, Erik H; Kaiser, Christoph; von Freymann, Georg


    We present a real-time measurement technique, based on time-stretching for measuring the temporal dynamic of ultrafast absorption variations with a sampling-rate of up to 1.1 TS/s. The single-shot captured data are stretched in a resonator-based time-stretch system with a variable stretch-factor of up to 13.8. The time-window of the time-stretch system for capturing the signal of interest is about 800 ps with an update-rate of 10 MHz. An adapted optical backpropagation algorithm is introduced for reconstructing the original unstretched event. As proof-of-principle the temporal characteristic of a picosecond semiconductor saturable absorber mirror is measured: The real-time results agree well with the results of a conventional pump-probe experiment. The time-stretch technique potentially allows to gain access to a large field of ultrafast absorption variations like semiconductor charge carrier dynamics, irreversible polymerization processes, and saturable absorber materials.

  1. Time-varying surrogate data to assess nonlinearity in nonstationary time series: application to heart rate variability.

    Faes, Luca; Zhao, He; Chon, Ki H; Nollo, Giandomenico


    We propose a method to extend to time-varying (TV) systems the procedure for generating typical surrogate time series, in order to test the presence of nonlinear dynamics in potentially nonstationary signals. The method is based on fitting a TV autoregressive (AR) model to the original series and then regressing the model coefficients with random replacements of the model residuals to generate TV AR surrogate series. The proposed surrogate series were used in combination with a TV sample entropy (SE) discriminating statistic to assess nonlinearity in both simulated and experimental time series, in comparison with traditional time-invariant (TIV) surrogates combined with the TIV SE discriminating statistic. Analysis of simulated time series showed that using TIV surrogates, linear nonstationary time series may be erroneously regarded as nonlinear and weak TV nonlinearities may remain unrevealed, while the use of TV AR surrogates markedly increases the probability of a correct interpretation. Application to short (500 beats) heart rate variability (HRV) time series recorded at rest (R), after head-up tilt (T), and during paced breathing (PB) showed: 1) modifications of the SE statistic that were well interpretable with the known cardiovascular physiology; 2) significant contribution of nonlinear dynamics to HRV in all conditions, with significant increase during PB at 0.2 Hz respiration rate; and 3) a disagreement between TV AR surrogates and TIV surrogates in about a quarter of the series, suggesting that nonstationarity may affect HRV recordings and bias the outcome of the traditional surrogate-based nonlinearity test.

  2. The influence of hydrophylic polymers on the release rate of calcium dobesilate in hydrogel formulation assessed in vitro using porcine ear skin

    Wojcik-Pastuszka Dorota


    Full Text Available A shortage of available experimental data exists in the available bibliography on the release rate of calcium dobesilate (CD from hydrogel formulations. Thus, the aim of the study was to evaluate the effect of selected hydrophilic nonionic polymers and anionic polymers on the release rate of CD from formulation provided for dermal application, as compared to the reference product in the market. The work utilized excised pork skin, while, Methylcellulose (MC, hydroxypropyl methylcellulose (HPMC, and anionic polymers (copolymers of acrylic acid were used as CD carriers. The release study was executed by the pharmacopoeial paddle method, with extraction cells and fresh excised porcine skin as a membrane. CD in aqueous acceptor fluid was quantified by UV-VIS spectrometry at 300 nm. Subsequently, the kinetic curves were fitted to a zero-order kinetics model, a first-order kinetics model, a second-order kinetics model, as well as to the Higuchi model. The work saw that porcine ear skin influences the release pattern of the CD, compared to the artificial membrane. In the study, the evaluated formulations with MC, polyacrylic acid (PA and polyacrylate crosspolymer 11 (PC-11 deliver over 60% of the active component (AC, within 250 min, through the excised porcine ear skin, to the acceptor compartment. Moreover, the release observed via porcine ear skin to the aqueous acceptor compartment is congenial to zero-order or first-order kinetics. In addition, the formulations prepared on the basis of MC and PA appear to control AC delivery, independently of actual concentration of AC.

  3. Release of a single neurotransmitter from an identified interneuron coherently affects motor output on multiple time scales.

    Dacks, Andrew M; Weiss, Klaudiusz R


    Neurotransmitters can have diverse effects that occur over multiple time scales often making the consequences of neurotransmission difficult to predict. To explore the consequences of this diversity, we used the buccal ganglion of Aplysia to examine the effects of GABA release by a single interneuron, B40, on the intrinsic properties and motor output of the radula closure neuron B8. B40 induces a picrotoxin-sensitive fast IPSP lasting milliseconds in B8 and a slow EPSP lasting seconds. We found that the excitatory effects of this slow EPSP are also mediated by GABA. Together, these two GABAergic actions structure B8 firing in a pattern characteristic of ingestive programs. Furthermore, we found that repeated B40 stimulation induces a persistent increase in B8 excitability that was occluded in the presence of the GABA B receptor agonist baclofen, suggesting that GABA affects B8 excitability over multiple time scales. The phasing of B8 activity during the feeding motor programs determines the nature of the behavior elicited during that motor program. The persistent increase in B8 excitability induced by B40 biased the activity of B8 during feeding motor programs causing the motor programs to become more ingestive in nature. Thus, a single transmitter released from a single interneuron can have consequences for motor output that are expressed over multiple time scales. Importantly, despite the differences in their signs and temporal characteristics, the three actions of B40 are coherent in that they promote B8 firing patterns that are characteristic of ingestive motor outputs.

  4. On the quantification of heart rate variability spectral parameters using time-frequency and time-varying methods.

    Mainardi, Luca T


    In the last decades, one of the main challenges in the study of heart rate variability (HRV) signals has been the quantification of the low-frequency (LF) and high-frequency (HF) components of the HRV spectrum during non-stationary events. At this regard, different time-frequency and time-varying approaches have been proposed with the aim to track the modification of the HRV spectra during ischaemic attacks, provocative stress testing, sleep or daily-life activities. The quantitative evaluation of power (and frequencies) of the LF and HF components has been approached in various ways depending on the selected time-frequency method. This paper is an excursus through the most common time-frequency/time-varying representation of the HRV signal with a special emphasis on the algorithms employed for the reliable quantification of the LF and HF parameters and their tracking.

  5. Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation.

    Johannsson, G; Nilsson, A G; Bergthorsdottir, R; Burman, P; Dahlqvist, P; Ekman, B; Engström, B E; Olsson, T; Ragnarsson, O; Ryberg, M; Wahlberg, J; Biller, B M K; Monson, J P; Stewart, P M; Lennernäs, H; Skrtic, S


    Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile. The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of conventional hydrocortisone tablets. We conducted an open, randomized, two-period, 12-wk crossover multicenter trial with a 24-wk extension at five university hospital centers. The trial enrolled 64 adults with primary AI; 11 had concomitant diabetes mellitus (DM). The same daily dose of hydrocortisone was administered as OD dual-release or TID. We evaluated cortisol pharmacokinetics. Compared with conventional TID, OD provided a sustained serum cortisol profile 0-4 h after the morning intake and reduced the late afternoon and the 24-h cortisol exposure. The mean weight (difference = -0.7 kg, P = 0.005), systolic blood pressure (difference = -5.5 mm Hg, P = 0.0001) and diastolic blood pressure (difference: -2.3 mm Hg; P = 0.03), and glycated hemoglobin (absolute difference = -0.1%, P = 0.0006) were all reduced after OD compared with TID at 12 wk. Compared with TID, a reduction in glycated hemoglobin by 0.6% was observed in patients with concomitant DM during OD (P = 0.004). The OD dual-release tablet provided a more circadian-based serum cortisol profile. Reduced body weight, reduced blood pressure, and improved glucose metabolism were observed during OD treatment. In particular, glucose metabolism improved in patients with concomitant DM.

  6. Time-variant modelling of heart rate responses to exercise intensity during road cycling.

    Lefever, Joris; Berckmans, Daniel; Aerts, Jean-Marie


    The aim of this study was to determine if heart rate responses to training intensity during road cycling could be modelled with compact time-variant mathematical model structures. The model performance was evaluated in terms of model order (complexity), number of inputs and parameter estimation methods used (time-invariant vs. time-variant). Thirteen male cyclists performed two identical cycling tests of 27 km on the road. Uphill sections were introduced to induce dynamic variations in heart rate. The heart rate and training intensity, represented by power output and road inclination, were measured in real-time. Taking only power as system input allowed to explain the variations in heart rate in an accurate way R2 T = 0.86 ± 0.08, since adding the road inclination as an additional input did not significantly improve the modelling performance R2 T = 0.87 ± 0.08, P = 0.32. Furthermore, we demonstrated that models with first-order dynamics accurately describes the heart rate responses to power variations R2 T = 0.86 ± 0.08, but that more complex second-order model structures R2 T = 0.88 ± 0.08 were significantly better than the first-order model structures (P = 0.028). Finally, the heart rate dynamics appeared to be time-variant, since the time-variant model structures R2 T = 0.89 ± 0.07 were significantly better than the time-invariant model structures R2 T = 0.84 ± 0.08, P = 0.0002. So, compact time-variant second-order model structures could be used to model the heart rate response to training intensity as a basis for training optimisation.

  7. The timing of phasic transmitter release is Ca2+-dependent and lacks a direct influence of presynaptic membrane potential

    Felmy, Felix; Neher, Erwin; Schneggenburger, Ralf


    Ca2+ influx through voltage-gated Ca2+ channels and the resulting elevation of intracellular Ca2+ concentration, [Ca2+]i, triggers transmitter release in nerve terminals. However, it is controversial whether in addition to the opening of Ca2+ channels, membrane potential directly affects transmitter release. Here, we assayed the influence of membrane potential on transmitter release at the calyx of Held nerve terminals. Transmitter release was evoked by presynaptic Ca2+ uncaging, or by presyn...

  8. Analysis of Real-Time Monitoring Technology andDynamic Rating method of Transmission Lines

    徐峰; 刘聪


    Transmission line dynamic rating method as an important part of the inteligent transmission technical system can effectively solve the problem of insufficient power supply capacity of transmission lines. In this paper,the overal scheme of the dynamic rating method is briefly ilustrated. Next,transmission lines real-time monitoring technology and transmission line dynamic rating method are described respectively. Finaly,the influence of external factors on carrying capacity of transmission lines is analysed. Numerical results show that the proposed dynamic rating method is very effective.

  9. Distribution Function Estimation of the Timing Jitter in Sample Rate Converter

    Vipan Kakkar


    Full Text Available The aim of digital sample rate conversion is to bring a digital audio signal from one sample frequency to another. The distortion of the audio signal introduced by the sample rate converter should be as low as possible. The generation of the output samples from the inputsamples may be performed by the application of various methods. In this paper, a new technique of digital sample-rate converter is proposed. We perform the analysis for distribution function estimation of the timing jitter in proposed digital sample rate converter.

  10. A real-time phoneme counting algorithm and application for speech rate monitoring.

    Aharonson, Vered; Aharonson, Eran; Raichlin-Levi, Katia; Sotzianu, Aviv; Amir, Ofer; Ovadia-Blechman, Zehava


    Adults who stutter can learn to control and improve their speech fluency by modifying their speaking rate. Existing speech therapy technologies can assist this practice by monitoring speaking rate and providing feedback to the patient, but cannot provide an accurate, quantitative measurement of speaking rate. Moreover, most technologies are too complex and costly to be used for home practice. We developed an algorithm and a smartphone application that monitor a patient's speaking rate in real time and provide user-friendly feedback to both patient and therapist. Our speaking rate computation is performed by a phoneme counting algorithm which implements spectral transition measure extraction to estimate phoneme boundaries. The algorithm is implemented in real time in a mobile application that presents its results in a user-friendly interface. The application incorporates two modes: one provides the patient with visual feedback of his/her speech rate for self-practice and another provides the speech therapist with recordings, speech rate analysis and tools to manage the patient's practice. The algorithm's phoneme counting accuracy was validated on ten healthy subjects who read a paragraph at slow, normal and fast paces, and was compared to manual counting of speech experts. Test-retest and intra-counter reliability were assessed. Preliminary results indicate differences of -4% to 11% between automatic and human phoneme counting. Differences were largest for slow speech. The application can thus provide reliable, user-friendly, real-time feedback for speaking rate control practice.

  11. Time-Efficient High-Rate Data Flooding in One-Dimensional Acoustic Underwater Sensor Networks.

    Kwon, Jae Kyun; Seo, Bo-Min; Yun, Kyungsu; Cho, Ho-Shin


    Because underwater communication environments have poor characteristics, such as severe attenuation, large propagation delays and narrow bandwidths, data is normally transmitted at low rates through acoustic waves. On the other hand, as high traffic has recently been required in diverse areas, high rate transmission has become necessary. In this paper, transmission/reception timing schemes that maximize the time axis use efficiency to improve the resource efficiency for high rate transmission are proposed. The excellence of the proposed scheme is identified by examining the power distributions by node, rate bounds, power levels depending on the rates and number of nodes, and network split gains through mathematical analysis and numerical results. In addition, the simulation results show that the proposed scheme outperforms the existing packet train method.

  12. Time-Efficient High-Rate Data Flooding in One-Dimensional Acoustic Underwater Sensor Networks

    Jae Kyun Kwon


    Full Text Available Because underwater communication environments have poor characteristics, such as severe attenuation, large propagation delays and narrow bandwidths, data is normally transmitted at low rates through acoustic waves. On the other hand, as high traffic has recently been required in diverse areas, high rate transmission has become necessary. In this paper, transmission/reception timing schemes that maximize the time axis use efficiency to improve the resource efficiency for high rate transmission are proposed. The excellence of the proposed scheme is identified by examining the power distributions by node, rate bounds, power levels depending on the rates and number of nodes, and network split gains through mathematical analysis and numerical results. In addition, the simulation results show that the proposed scheme outperforms the existing packet train method.

  13. Adaptive real-time forecast of river flow-rates from rainfall data

    Bolzern, P.; Ferrario, M.; Fronza, G.


    The paper describes a stochastic rainfall—river flow-rate model of the ARMAX type. Then a real-time Kalman predictor is derived from the model, namely a recursive relationship which, at the beginning of each time step, supplies the "best" forecast of future flow-rate on the basis of current rainfall and flow-rate measurements. Three different versions (ordered in the sense of increasing complexity) of the predictor are considered, corresponding to different approaches for estimating parameters and noise statistics of the stochastic model. The flood forecast performance of all predictors is tested on a real case (Lake Maggiore water system). The performance is satisfactory (for instance correlations about 99% between forecast and true values, standard deviation of the forecast error less than 1% of the average flood flow-rate) and conspicuously better than the one given by the trivial persistence predictor (the future flow-rate is the present one).

  14. Effects of a combination of 3,4-methylenedioxymeth amphetamine and caffeine on real time stimulated dopamine release in the rat striatum: Studies using fast cyclic voltammetry.

    O'Connor, J J; O'Boyle, K M; Lowry, J P


    It is well documented that caffeine exacerbates the hyperthermia associated with acute exposure to 3,4-methylenedioxymethamphetamine (MDMA) in rats. Previous reports have also indicated that MDMA-related enhancement of dopamine release is exacerbated in the presence of caffeine. In the present study we have examined whether the effects of MDMA on real-time stimulated dopamine release, in the absence of uptake inhibition, are accentuated in the presence of caffeine. Isolated striatal slices from adult male Wistar rats were treated acutely with MDMA, caffeine, or a combination, and their effects on single and 5pulse stimulated dopamine release monitored using the technique of fast cyclic voltammetry. Caffeine at 10 or 100μM had no significant effect on single pulse stimulated dopamine release. However 100μM caffeine caused a significant peak increase in 5pulse stimulated dopamine release. Both 1 and 30μM MDMA gave rise to a significant increase in both single and 5-pulse dopamine release and reuptake. A combination of 100μM caffeine and 1 or 30μM MDMA did not significantly enhance the effects of MDMA on single or 5pulse dopamine release and reuptake when compared to that applied alone. Utilizing single action potential dependent dopamine release, these results do not demonstrate a caffeine-enhanced MDMA-induced dopamine release. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Yield performance of upland rice cultivars at different rates and times of nitrogen application

    José Hildernando Bezerra Barreto


    Full Text Available Nitrogen is the most important nutrient for rice (Oryza sativa L yields. This study aimed to evaluate the response of upland rice cultivars to N rate and application times in a randomized block design, in subdivided plots with four replications. The studied factors were five rice cultivars (BRS MG Curinga, BRS Monarca, BRS Pepita, BRS Primavera, and BRS Sertaneja, three application times (100 % at planting, 50 % at planting - 50 % at tillering and 100 % at tillering and four N rates (0, 50, 100, and 150 kg ha-1. All cultivars responded to increased rates and different times of N application, especially BRS Primavera and BRS Sertaneja, which were the most productive when 50 % N rates were applied at sowing and 50 % at tillering. The response of cultivar BRS Monarca to N fertilization was best when 100 % of the fertilizer was applied at tillering.

  16. Matrix tablets: the effect of hydroxypropyl methylcellulose/anhydrous dibasic calcium phosphate ratio on the release rate of a water-soluble drug through the gastrointestinal tract I. In vitro tests.

    Mamani, Pseidy L; Ruiz-Caro, Roberto; Veiga, María D


    Different hydroxypropyl methylcellulose (HPMC)/anhydrous dibasic calcium phosphate (ADCP) matrix tablets have been developed aiming to evaluate the influence of both components ratio in the control release of a water-soluble drug (theophylline). In order to characterise the matrix tablets, swelling, buoyancy and dissolution studies have been carried out in different aqueous media (demineralised water, progressive pH medium, simulated gastric fluid, simulated intestinal fluid and simulated colonic fluid). The HPMC/ADCP ratio has turned out to be the determinant in the matrix behaviour: the HPMC characteristic swelling behaviour was modulated, in some cases, by the ADCP characteristic acidic dissolution. When the HPMC/ADCP ratio was ≥0.69, buoyancy, continuous swelling and low theophylline dissolution rate from the matrices (H1, H2 and H3) were observed in all dissolution media. Consequently, these formulations could be adequate as gastro-retentive drug delivery systems. Additionally, HPMC/ADCP ratio ≤0.11 (H5 and H6) induces a pH-dependent drug release which could be applied to design control drug release enteric formulations (with a suitable enteric coating). Finally, a HPMC/ADCP ratio between 0.11 and 0.69 (H4) yield a gastrointestinal controlled drug release, due to its time-dependent buoyancy (7 h) and a total drug delivery in 17 h in simulated colonic fluid.

  17. Predicting demographically sustainable rates of adaptation: can great tit breeding time keep pace with climate change?

    Gienapp, Phillip; Lof, Marjolein; Reed, Thomas E; McNamara, John; Verhulst, Simon; Visser, Marcel E


    Populations need to adapt to sustained climate change, which requires micro-evolutionary change in the long term. A key question is how the rate of this micro-evolutionary change compares with the rate of environmental change, given that theoretically there is a 'critical rate of environmental change' beyond which increased maladaptation leads to population extinction. Here, we parametrize two closely related models to predict this critical rate using data from a long-term study of great tits (Parus major). We used stochastic dynamic programming to predict changes in optimal breeding time under three different climate scenarios. Using these results we parametrized two theoretical models to predict critical rates. Results from both models agreed qualitatively in that even 'mild' rates of climate change would be close to these critical rates with respect to great tit breeding time, while for scenarios close to the upper limit of IPCC climate projections the calculated critical rates would be clearly exceeded with possible consequences for population persistence. We therefore tentatively conclude that micro-evolution, together with plasticity, would rescue only the population from mild rates of climate change, although the models make many simplifying assumptions that remain to be tested.

  18. Response rate, response time, and economic costs of survey research: A randomized trial of practicing pharmacists.

    Hardigan, Patrick C; Popovici, Ioana; Carvajal, Manuel J


    There is a gap between increasing demands from pharmacy journals, publishers, and reviewers for high survey response rates and the actual responses often obtained in the field by survey researchers. Presumably demands have been set high because response rates, times, and costs affect the validity and reliability of survey results. Explore the extent to which survey response rates, average response times, and economic costs are affected by conditions under which pharmacist workforce surveys are administered. A random sample of 7200 U.S. practicing pharmacists was selected. The sample was stratified by delivery method, questionnaire length, item placement, and gender of respondent for a total of 300 observations within each subgroup. A job satisfaction survey was administered during March-April 2012. Delivery method was the only classification showing significant differences in response rates and average response times. The postal mail procedure accounted for the highest response rates of completed surveys, but the email method exhibited the quickest turnaround. A hybrid approach, consisting of a combination of postal and electronic means, showed the least favorable results. Postal mail was 2.9 times more cost effective than the email approach and 4.6 times more cost effective than the hybrid approach. Researchers seeking to increase practicing pharmacists' survey participation and reduce response time and related costs can benefit from the analytical procedures tested here. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release

    Fan, Zhen; Sun, Leming; Huang, Yujian; Wang, Yongzhong; Zhang, Mingjun


    Peptide nanostructures are biodegradable and are suitable for many biomedical applications. However, to be useful imaging probes, the limited intrinsic optical properties of peptides must be overcome. Here we show the formation of tryptophan-phenylalanine dipeptide nanoparticles (DNPs) that can shift the peptide's intrinsic fluorescent signal from the ultraviolet to the visible range. The visible emission signal allows the DNPs to act as imaging and sensing probes. The peptide design is inspired by the red shift seen in the yellow fluorescent protein that results from π-π stacking and by the enhanced fluorescence intensity seen in the green fluorescent protein mutant, BFPms1, which results from the structure rigidification by Zn(II). We show that DNPs are photostable, biocompatible and have a narrow emission bandwidth and visible fluorescence properties. DNPs functionalized with the MUC1 aptamer and doxorubicin can target cancer cells and can be used to image and monitor drug release in real time.

  20. Time delay estimation in a reverberant environment by low rate sampling of impulsive acoustic sources

    Omer, Muhammad


    This paper presents a new method of time delay estimation (TDE) using low sample rates of an impulsive acoustic source in a room environment. The proposed method finds the time delay from the room impulse response (RIR) which makes it robust against room reverberations. The RIR is considered a sparse phenomenon and a recently proposed sparse signal reconstruction technique called orthogonal clustering (OC) is utilized for its estimation from the low rate sampled received signal. The arrival time of the direct path signal at a pair of microphones is identified from the estimated RIR and their difference yields the desired time delay. Low sampling rates reduce the hardware and computational complexity and decrease the communication between the microphones and the centralized location. The performance of the proposed technique is demonstrated by numerical simulations and experimental results. © 2012 IEEE.

  1. Analysis of Heart Rate Variability Using Time-Varying Filtering of Heart Transplanted Patients

    Laouini, Ghailen; Meste, Olivier; Meo, Marianna


    International audience; In this paper, we analyze the heart rate variability (HRV), obtained by using the time-varying integral pulse frequency modulation (TVIPFM) which is well adapted to the exercise stress testing. We consider that the mean heart period is varying function of time, during exercise. This technique allows the estimation of the autonomic nervous system modulation (ANS) from the beat occurrences. The estimated respiratory sinus arrhythmia is then filtered in the time-frequency...

  2. Time-variant power spectral analysis of heart-rate time series by autoregressive moving average (ARMA) method

    V P S Naidu; M R S Reddy


    Frequency domain representation of a short-term heart-rate time series (HRTS) signal is a popular method for evaluating the cardiovascular control system. The spectral parameters, viz. percentage power in low frequency band (%PLF), percentage power in high frequency band (%PHF), power ratio of low frequency to high frequency (PRLH), peak power ratio of low frequency to high frequency (PPRLH) and total power (TP) are extrapolated from the averaged power spectrum of twenty-five healthy subjects, and 16 acute anterior-wall and nine acute inferior-wall myocardial infarction (MI) patients. It is observed that parasympathetic activity predominates in healthy subjects. From this observation we conclude that during acute myocardial infarction, the anterior wall MI has stimulated sympathetic activity, while the acute inferior wall MI has stimulated parasympathetic activity. Results obtained from ARMA-based analysis of heart-rate time series signals are capable of complementing the clinical examination results.

  3. Correlation Between Ecospace and Metabolic Rate of Marine Organisms Through Geologic Time

    Duong, C.; Tenorio, A.; Heim, N. A.; Payne, J.


    Marine organisms are the most abundant fossils scientists have discovered in the fossil record. Various factors affect the survival rate of individual organisms and entire genera including metabolic rate, genetic diversity, environmental availability, and ecology. We however chose to focus our attention on studying mean metabolic rates in correlation to life modes. A marine organism's life mode is determined by three criteria: tiering, motility, and feeding mechanism. We believe an organism's life mode has an effect on its survivorship, especially since ecospace is the "primary determinant of routine metabolic rate for marine organisms" (Seibel & Drazen 2007). Using the metabolic equation, we were able to plot metabolic rate changes for various life modes over time. Seibel and Drazen (2007) explain that "metabolic variation in the ocean results from interspecific differences in ecological energy demand," thus allowing us to hypothesize that with different combinations of life modes, different marine organisms will have varying metabolic rates. To further compare our data, we created a heatmap to show the change in metabolic rates over the last 540 million years. Based on the collection of data, metabolic rates of marine organisms have shown an increasing trend. When analyzing ecospaces, pelagic (living in the water column), free moving organisms have relatively high metabolic rates in comparison to other modes of tiering. In other life modes, there's a general trend of genera maintaining a stabilized and moderate metabolic rate that is neither extremely high nor low.

  4. [Preparation and evaluation of press-coated aminophylline tablet using crystalline cellulose and polyethylene glycol in the outer shell for timed-release dosage forms].

    Watanabe, Yoshiteru; Mukai, Baku; Kawamura, Ken-ichi; Ishikawa, Tatsuya; Namiki, Michihiro; Utoguchi, Naoki; Fujii, Makiko


    In an attempt to achieve chronopharmacotherapy for asthma, press-coated tablets (250 mg), which contained aminophylline in the core tablet in the form of low-substituted hydroxypropylcellulose (L-HPC) and coated with crystalline cellulose (PH-102) and polyethylene glycol (PEG) at various molecular weights and mixing ratios in the amounts of PH-102 and PEG as the outer shell (press-coating material), were prepared (chronopharmaceutics). Their applicability as timed-release (delayed-release) tablets with a lag time of disintegration and a subsequent rapid drug release phase was investigated. Various types of press-coated tablets were prepared using a tableting machine, and their aminophylline dissolution profiles were evaluated by the JP paddle method. Tablets with the timed-release characteristics could be prepared, and the lag time of disintegration was prolonged as the molecular weight and the amount of PEG, for example PEG 500,000, in the outer shell were increased. The lag time of disintegration could be controlled by the above-mentioned method, however, the pH of the medium had no effect on disintegration of the tablet and dissolution behavior of theophylline. The press-coated tablet (core tablet:aminophylline 50 mg, L-HPC and PEG 6000; outer shell:PH-102:PEG = 8:2 200 mg) with the timed-release characteristics was administered orally to rabbits for an in vivo test. Theophylline was first detected in plasma more than 2 h after administration; thus, this tablet showed a timed-release characteristics in the gastrointestinal tract. The time (tmax) required to reach the maximum plasma theophylline concentration (Cmax) observed after administration of the press-coated tablet was significantly (p 24) between the press-coated tablet and aminophylline solution. These results suggest that the press-coated aminophylline tablet (with the timed-release characteristic) offers a promising forms of theophylline chronotherapy for asthma.

  5. Heart rate time series characteristics for early detection of infections in critically ill patients.

    Tambuyzer, T; Guiza, F; Boonen, E; Meersseman, P; Vervenne, H; Hansen, T K; Bjerre, M; Van den Berghe, G; Berckmans, D; Aerts, J M; Meyfroidt, G


    It is difficult to make a distinction between inflammation and infection. Therefore, new strategies are required to allow accurate detection of infection. Here, we hypothesize that we can distinguish infected from non-infected ICU patients based on dynamic features of serum cytokine concentrations and heart rate time series. Serum cytokine profiles and heart rate time series of 39 patients were available for this study. The serum concentration of ten cytokines were measured using blood sampled every 10 min between 2100 and 0600 hours. Heart rate was recorded every minute. Ten metrics were used to extract features from these time series to obtain an accurate classification of infected patients. The predictive power of the metrics derived from the heart rate time series was investigated using decision tree analysis. Finally, logistic regression methods were used to examine whether classification performance improved with inclusion of features derived from the cytokine time series. The AUC of a decision tree based on two heart rate features was 0.88. The model had good calibration with 0.09 Hosmer-Lemeshow p value. There was no significant additional value of adding static cytokine levels or cytokine time series information to the generated decision tree model. The results suggest that heart rate is a better marker for infection than information captured by cytokine time series when the exact stage of infection is not known. The predictive value of (expensive) biomarkers should always be weighed against the routinely monitored data, and such biomarkers have to demonstrate added value.




    Full Text Available The white paper is on HINO 6 cylinder engine and the aim is to reduce the rejection rate of engines during testing due to the problems occur in valve timing and injection timing. The concept of Six Sigma is mainly practiced as a design to eliminate the production defects by improving the process of manufacturing. In the observation, the injection timing mark (spill mark is not perfectly done and also the imperfection in flywheel marking machine locator pin increases engine rejection. The aim is to eliminate the engines getting rejected during engine test due to problems arising in the injection timing and valve timing. As there are a lot of problems arising in the test bed where the engine is tested, few of which are related to injection timing and valve timing. These problems mainly arise due to changes in the valve and injection timing variation.

  7. Stellar masses, star formation rates, metallicities and AGN properties for 200,000 galaxies in the SDSS Data Release Two (DR2)

    Brinchmann, J; Heckman, T M; Kauffmann, G; Tremonti, C A; White, S D M; Brinchmann, Jarle; Charlot, Stephane; Heckman, Timothy M.; Kauffmann, Guinevere; Tremonti, Christy; White, Simon D.M.


    By providing homogeneous photometric and spectroscopic data of high quality for very large and objectively selected samples of galaxies, the Sloan Digital Sky Survey allows statistical studies of the physical properties of galaxies and AGN to be carried out at an unprecedented level of precision and detail. Here we publicly release catalogues of derived physical properties for 211,894 galaxies, including 33,589 narrow-line AGN. These are complete samples with well understood selection criteria drawn from the normal galaxy spectroscopic sample in the second SDSS public data release (DR2). We list properties obtained from the SDSS spectroscopy and photometry using modelling techniques presented in papers already published by our group. These properties include: stellar masses; stellar mass-to-light ratios; attenuation of the starlight by dust; indicators of recent major starbursts; current total and specific star-formation rates, both for the regions with spectroscopy and for the galaxies as a whole; gas-phase ...

  8. The Oil Price and Exchange Rate Relationship Revisited: A time-varying VAR parameter approach

    Vincent Brémond


    Full Text Available The aim of this paper is to study the relationship between the effective exchange rate of the dollar and the oil price dynamics from 1976 to 2013. We explore the links between financial factors (exchange rate, monetary policy, international liquidity and the oil price volatility. Using a Bayesian time-varying parameter vector auto-regressive estimation we demonstrate that the “historical coincidence” of oil and financial crises can be explained by the specificities of the relationship between these two commodities. The results of this paper are twofold. The US Dollar effective exchange rate elasticity of crude oil prices is not constant across time and remains negative from 1989: a depreciation of the effective exchange rate of the dollar triggers an increase of crude oil prices. This paper also demonstrates the contagion of financial commodities markets development upon the global economy.

  9. Time-Based Dithering Algorithm and Frame Rate Control Technique for STN LCD Controller

    LEIJianming; ZOUXuechen


    Time-based dithering algorithm and Frame rate control (FRC) technique applied to the STN liquid crystal display controller are presented. The dithering unit performs time-based dithering algorithm on pixel data to advantageously increase smoothness of an image displayed. The frame rate control unit is responsive to the dithering unit and performs frame rate controlling to generate more gray-shades, which may reduce flicker and visual artifacts. Results show that the gray shades displayed on images can be up to 256 for monochrome STN LCD panels or 2563 colors for color STN LCD panels respectively by using timebased dithering algorithm and frame rate control technique if each encoded pixel data is 8 bits. The images displayed on the STN liquid crystal display can get desirable grayshades and very little flicker and visual artifacts.

  10. A Low-Cost Time-Hopping Impulse Radio System for High Data Rate Transmission

    Jinyun Zhang


    Full Text Available We present an efficient, low-cost implementation of time-hopping impulse radio that fulfills the spectral mask mandated by the FCC and is suitable for high-data-rate, short-range communications. Key features are (i all-baseband implementation that obviates the need for passband components, (ii symbol-rate (not chip rate sampling, A/D conversion, and digital signal processing, (iii fast acquisition due to novel search algorithms, and (iv spectral shaping that can be adapted to accommodate different spectrum regulations and interference environments. Computer simulations show that this system can provide 110 Mbps at 7–10 m distance, as well as higher data rates at shorter distances under FCC emissions limits. Due to the spreading concept of time-hopping impulse radio, the system can sustain multiple simultaneous users, and can suppress narrowband interference effectively.

  11. A conversion formula for comparing pulse oximeter desaturation rates obtained with different averaging times.

    Jan Vagedes

    Full Text Available OBJECTIVE: The number of desaturations determined in recordings of pulse oximeter saturation (SpO2 primarily depends on the time over which values are averaged. As the averaging time in pulse oximeters is not standardized, it varies considerably between centers. To make SpO2 data comparable, it is thus desirable to have a formula that allows conversion between desaturation rates obtained using different averaging times for various desaturation levels and minimal durations. METHODS: Oxygen saturation was measured for 170 hours in 12 preterm infants with a mean number of 65 desaturations <90% per hour of arbitrary duration by using a pulse oximeter in a 2-4 s averaging mode. Using 7 different averaging times between 3 and 16 seconds, the raw red-to-infrared data were reprocessed to determine the number of desaturations (D. The whole procedure was carried out for 7 different minimal desaturation durations (≥ 1, ≥ 5, ≥ 10, ≥ 15, ≥ 20, ≥ 25, ≥ 30 s below SpO2 threshold values of 80%, 85% or 90% to finally reach a conversion formula. The formula was validated by splitting the infants into two groups of six children each and using one group each as a training set and the other one as a test set. RESULTS: Based on the linear relationship found between the logarithm of the desaturation rate and the logarithm of the averaging time, the conversion formula is: D2 = D1 (T2/T1(c, where D2 is the desaturation rate for the desired averaging time T2, and D1 is the desaturation rate for the original averaging time T1, with the exponent c depending on the desaturation threshold and the minimal desaturation duration. The median error when applying this formula was 2.6%. CONCLUSION: This formula enables the conversion of desaturation rates between different averaging times for various desaturation thresholds and minimal desaturation durations.

  12. Continuous Time Models of Interest Rate: Testing the Mexican Data (1998-2006)

    Jose Luis de la Cruz; Elizabeth Ortega.


    Distinct parametric models in continuous time for the interest rates are tested by means of a comparative analysis of the implied parametric and nonparametric densities. In this research the statistic developed by Ait-Sahalia (1996a) has been applied to the Mexican CETES (28 days) interest rate in the period 1998-2006. With this technique, the discrete approximation to the continuous model is unnecessary even when the data are discrete. The results allow to affirm that the models of interest ...

  13. Are low Danish fertility rates explained by changes in timing of births?

    Hvidtfeldt, Ulla A; Gerster, Mette; Knudsen, Lisbeth B;


    AIMS: The most commonly used indicator of fertility, the period total fertility rate (TFR(p)), tends to underestimate actual fertility when women delay childbearing. The objective of this study was to examine to which extent fluctuations in Danish fertility rates result from changes in timing...... of births and, thus, whether the conventional TFR(p) is a distorted indicator of fertility quantum. In addition, we investigated whether such changes in timing explained the observed regional differences in the TFR(p) in Denmark. METHODS: The study applied age-, period-, county-, and parity-specific data...... from the Danish Fertility of Women and Couples Dataset, 1980-2001. We evaluated fluctuations in period fertility rates by the tempo-adjusted TFR(') - a proposed variant of the conventional TFR(p) taking period changes in timing of births into account. Tempo-effects were given by the difference between...

  14. First-time NCLEX-RN pass rate: measure of program quality or something else?

    Taylor, Heidi; Loftin, Collette; Reyes, Helen


    The first-time NCLEX-RN(®) pass rate is considered by many to be the primary, if not sole, indicator of the quality of prelicensure nursing education programs. Used by state boards of nursing, educational program accreditors, and nursing faculty, the first-time NCLEX-RN pass rate influences important decisions about overall program quality, admission and progression policies, curricula, and teaching and learning practices. In this article, the authors call for a professional dialogue about the use of first-time pass rate (F-TPR) as an indicator of program quality, offer alternative methods for using the F-TPR as one measure of program quality, and suggest further research. One program's experience with low F-TPRs is offered as an exemplar of the unintended negative consequences that occur when the F-TPR is used as a sole criterion by a state board of nursing in judging a program's quality.


    TAN Guang-ming; WANG Jun; SHU Cai-wen; LAI Yong-hui


    By means of flumes, experiments have been done in order to determine the effects of consolidation time and particle size on scour rates of cohesive sediment. Experimental results shown dry unit weight increased and scour rates decreased during the course of consolidation, the resistance to scour was related to consolidation time, but it presented different consolidation properties that depended on particle size. For the finer particle, the consolidation process was longer, the range of dry unit weight altered was greater, the consolidated sediments moved in chunks. On the other hand, based on analysis of the relationship of dry unit weight change with consolidation time, the simplified analytical expressions of dry unit weight and scour rates were derived, the results were checked with experimental data in the same flow situation and good agreements were achieved. Since the effects of different particle size were considered during the process of consolidation, the variations of consolidation properties were well reflected in these formulas.

  16. Impact of different discharge patterns on bed occupancy rate and bed waiting time: a simulation approach.

    Zhu, Zhecheng


    Beds are one of the most important resources in a healthcare system. How to manage beds efficiently is an important indicator of the efficiency of the healthcare system. Bed management is challenging to many healthcare service providers in many aspects. In recent years, population growth and aging society impose extra pressure on bed requirement. There are usually two key performance indicators of a bed management system: bed occupancy rate and bed waiting time. In this paper, different discharge patterns and their impacts on the bed occupancy rate and bed waiting time are studied. A discrete event simulation model is constructed to evaluate the existing discharge pattern in a Singapore regional hospital using actual hospital admission and discharge transaction data. Then different discharge patterns are tested in the same context. Simulation results show that a proper discharge pattern significantly smoothes the fluctuation of bed occupancy rate and reduce the bed waiting time.

  17. Flouride release from various restorative materials.

    Bala, O; Uçtaşli, M; Can, H; Türköz, E; Can, M


    Fluoride release from six light-activated restorative materials, including two resinmodified glass-ionomers, two composites, and two compomers, was evaluated and compared with one conventional acid-based glass-ionomer cement. The amount and rate of release varied among the tested materials. Both resin-modified glass-ionomers and the conventional acid-base glass-ionomer cements released more fluoride then the composites and compomers (p < 0.05). Additionally, composite materials released less fluoride than compomer materials (p < 0.05). Release of fluoride by the tested materials showed a significant decrease after all the tested time intervals.

  18. How Do Output Growth Rate Distributions Look Like? Some Time-Series Evidence on OECD Countries

    Fagiolo, G; Roventini, A; Fagiolo, Giorgio; Napoletano, Mauro; Roventini, Andrea


    This paper investigates the statistical properties of within-country GDP and industrial production (IP) growth rate distributions. Many empirical contributions have recently pointed out that cross-section growth rates of firms, industries and countries all follow Laplace distributions. In this work, we test whether also within-country, time-series GDP and IP growth rates can be approximated by tent-shaped distributions. We fit output growth rates with the exponential-power (Subbotin) family of densities, which includes as particular cases both the Gaussian and the Laplace distributions. We find that, for a large number of OECD countries including the U.S., both GDP and IP growth rates are Laplace distributed. Moreover, we show that fat-tailed distributions robustly emerge even after controlling for outliers, autocorrelation and heteroscedasticity.

  19. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently

    Carolien M. S. Schophuizen


    Full Text Available In renal failure, the systemic accumulation of uremic waste products is strongly associated with the development of a chronic inflammatory state. Here, the effect of cationic uremic toxins on the release of inflammatory cytokines and endothelin-1 (ET-1 was investigated in conditionally immortalized proximal tubule epithelial cells (ciPTEC. Additionally, we examined the effects of ET-1 on the cellular uptake mediated by organic cation transporters (OCTs. Exposure of ciPTEC to cationic uremic toxins initiated production of the inflammatory cytokines IL-6 (117 ± 3%, p < 0.001, IL-8 (122 ± 3%, p < 0.001, and ET-1 (134 ± 5%, p < 0.001. This was accompanied by a down-regulation of OCT mediated 4-(4-(dimethylaminostyryl-N-methylpyridinium-iodide (ASP+ uptake in ciPTEC at 30 min (23 ± 4%, p < 0.001, which restored within 60 min of incubation. Exposure to ET-1 for 24 h increased the ASP+ uptake significantly (20 ± 5%, p < 0.001. These effects could be blocked by BQ-788, indicating activation of an ET-B-receptor-mediated signaling pathway. Downstream the receptor, iNOS inhibition by (N(G‐monomethyl‐l‐arginine l-NMMA acetate or aminoguanidine, as well as protein kinase C activation, ameliorated the short-term effects. These results indicate that uremia results in the release of cytokines and ET-1 from human proximal tubule cells, in vitro. Furthermore, ET-1 exposure was found to regulate proximal tubular OCT transport activity in a differential, time-dependent, fashion.

  20. Does time of day influence cancer detection and recall rates in mammography?

    Stinton, Chris; Jenkinson, David; Adekanmbi, Victor; Clarke, Aileen; Taylor-Phillips, Sian


    Background: The interpretation of screening mammograms is influenced by factors such as reader experience and their annual interpretative volume. There is some evidence that time of day can also have an effect, with better diagnostic accuracy for readings conducted early in the day. This is not a consistent finding, however. The aim of our study is to provide further evidence on whether there is an effect of time of day on recall- and breast cancer detection rates. Method: We analysed breast screening data from 222,577 women from the Midlands of England. Data were split into three eight hour periods: 0900-1700, 1700-0100, 0100-0900. Differences in recall- and cancer detection rates were analysed using multilevel logistic regression models. Results: Recall rates were lowest for mammograms read between the 1700-0100 time period. Cancer detection rates were lowest during the 0100-0900 time period. Conclusions: Our findings suggest that there are fluctuations in recall- and cancer detection rates over the course of the day.

  1. [Effects of nitrogen fertilization rate and harvest time on summer maize grain yield and its quality].

    Zhang, Xue-lin; Wang, Qun; Zhao, Ya-li; Yang, Qing-hua; Li, Chao-hai


    In order to approach the optimal nitrogen fertilization rate and suitable harvest time for the high grain yield and quality of summer maize in Huanghe-Haihe Area, a field experiment with five nitrogen fertilization rates (0, 113, 181, 249, and 375 kg N x hm(-2)) and two harvest time (S1: September 23, conventional harvest time for local farmers, and S2: September 29, 6 days delayed) was conducted. The results showed that the kernel number, grain yield, and 1000-grain mass increased with nitrogen fertilization rate, but the differences were not significant. With increasing nitrogen fertilization rate, the protein and lysine contents of the grains increased, while the starch content decreased. After 6 days delayed for harvest, the grain yield, 1000-grain mass, and the starch and lysine contents of the grains increased, but the protein and crude fat contents decreased. Based on the yield level, the optimal nitrogen fertilization rate for the summer maize in Huanghe-Haihe Area was 113-180 kg N x hm(-2), and the suitable harvest time was from September 29 to October 5.

  2. Real time mass flow rate measurement using multiple fan beam optical tomography.

    Abdul Rahim, R; Leong, L C; Chan, K S; Rahiman, M H; Pang, J F


    This paper presents the implementing multiple fan beam projection technique using optical fibre sensors for a tomography system. From the dynamic experiment of solid/gas flow using plastic beads in a gravity flow rig, the designed optical fibre sensors are reliable in measuring the mass flow rate below 40% of flow. Another important matter that has been discussed is the image processing rate or IPR. Generally, the applied image reconstruction algorithms, the construction of the sensor and also the designed software are considered to be reliable and suitable to perform real-time image reconstruction and mass flow rate measurements.

  3. Use of recurrence plot and recurrence quantification analysis in Taiwan unemployment rate time series

    Chen, Wei-Shing


    The aim of the article is to answer the question if the Taiwan unemployment rate dynamics is generated by a non-linear deterministic dynamic process. This paper applies a recurrence plot and recurrence quantification approach based on the analysis of non-stationary hidden transition patterns of the unemployment rate of Taiwan. The case study uses the time series data of the Taiwan’s unemployment rate during the period from 1978/01 to 2010/06. The results show that recurrence techniques are able to identify various phases in the evolution of unemployment transition in Taiwan.

  4. Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate

    Buttafava, Mauro, E-mail:; Boso, Gianluca; Ruggeri, Alessandro; Tosi, Alberto [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy); Dalla Mora, Alberto [Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy)


    We present the design and characterization of a complete single-photon counting module capable of time-gating a silicon single-photon avalanche diode with ON and OFF transition times down to 110 ps, at repetition rates up to 80 MHz. Thanks to this sharp temporal filtering of incoming photons, it is possible to reject undesired strong light pulses preceding (or following) the signal of interest, allowing to increase the dynamic range of optical acquisitions up to 7 decades. A complete experimental characterization of the module highlights its very flat temporal response, with a time resolution of the order of 30 ps. The instrument is fully user-configurable via a PC interface and can be easily integrated in any optical setup, thanks to its small and compact form factor.

  5. Influence of cooking time and cooling rate on the functionality and microstructure of processed cheese spreads

    LI Xiaodong; WU Han; LIU Huaiwei


    The objective of this work was to study the influence of cooking time and cooling rate on functionality and microstructure of processed cheese spreads. When the cooking time was 20 min, the hardness and apparent viscosity were increased, and formed a homogenous, dense, and three-dimensional protein network, and a stronger gel was formed at this time. The slow cooling can increase the hardness and apparent viscosity of products, protein wall was thicker, and network was closer, so products can formed a stronger gel structure. The influence of cooking time on the functional properties was more significant than the influence of rapid cooling.

  6. Dynamic learning rates algorithm for BPNN to forecast time series of dam security


    Time series data of dam security have a large number of observed values and should be forecasted accurately in time.Neural networks have the powerful approach ablilities of arbitrary functions and have been broadly utilized in many domains.In this paper,a dynamic learning rate training algorithm of hack-propagation neural networks for time series forecasting is proposed and the networks with this algorithm are built to forecast time series of dam security.The application results demonostrate the efficiency of modelling and the effictiveness of forecasting.

  7. Estimating time to steady state using the effective rate of drug accumulation.

    Panebianco, Deborah L; Maes, Andrea


    Unless all of a drug is eliminated during each dosing interval, the plasma concentrations within a dosing interval will increase until the time course of change in plasma concentrations becomes invariant from one dosing interval to the next, resulting in steady state. A simple method for estimating drug concentration time to steady state based on multiple dose area under the plasma concentration-time curve and effective rate of drug accumulation is presented. Several point estimates and confidence intervals for time to 90% of steady state are compared, and a recommendation is made on how to summarize and present the results. Copyright © 2009 John Wiley & Sons, Ltd.

  8. Encoding of temporal information by timing, rate, and place in cat auditory cortex.

    Kazuo Imaizumi

    Full Text Available A central goal in auditory neuroscience is to understand the neural coding of species-specific communication and human speech sounds. Low-rate repetitive sounds are elemental features of communication sounds, and core auditory cortical regions have been implicated in processing these information-bearing elements. Repetitive sounds could be encoded by at least three neural response properties: 1 the event-locked spike-timing precision, 2 the mean firing rate, and 3 the interspike interval (ISI. To determine how well these response aspects capture information about the repetition rate stimulus, we measured local group responses of cortical neurons in cat anterior auditory field (AAF to click trains and calculated their mutual information based on these different codes. ISIs of the multiunit responses carried substantially higher information about low repetition rates than either spike-timing precision or firing rate. Combining firing rate and ISI codes was synergistic and captured modestly more repetition information. Spatial distribution analyses showed distinct local clustering properties for each encoding scheme for repetition information indicative of a place code. Diversity in local processing emphasis and distribution of different repetition rate codes across AAF may give rise to concurrent feed-forward processing streams that contribute differently to higher-order sound analysis.

  9. A Co-integration Approach to Forecasting Container Carriers' Time Charter Rates

    CHEN Fei-er; ZHANG Ren-yi


    A vector autoregressive model was developed for a sample of container carrier time charter rates.Although the series of time charter rates are themselves found non-stationary, thus precluding the use of manymodeling methodologies, evidence provided by co-integration tests points to the existence of stable long-termrelationships between the series. An assessment of the forecasts derived from the model suggests that the spec-ification of these long-term relationships does not improve the accuracy of long-term forecasts. These resultsare interpreted as a corroboration of the efficient market hypothesis.

  10. Periodic review inventory policy for non-instantaneous deteriorating items with time dependent deterioration rate

    Anwesha Samanta


    Full Text Available The paper studies a periodic review inventory model with no shortages and different demand rates during pre- and post- deterioration periods . Deterioration of units start after a fixed time interval, and the deterioration rate is time dependent. The model determines the optimal reorder interval and the optimal order quantity so as to minimize the total cost per unit length of an inventory cycle. An extension of the model to include price discount has been further considered. Numerical examples are presented to illustrate the model and a sensitivity analysis is also reported.

  11. Multiscale analysis of heart rate, blood pressure and respiration time series

    Angelini, L; Marinazzo, D; Nitti, L; Pellicoro, M; Pinna, G D; Stramaglia, S; Tupputi, S A


    We present the multiscale entropy analysis of short term physiological time series of simultaneously acquired samples of heart rate, blood pressure and lung volume, from healthy subjects and from subjects with Chronic Heart Failure. Evaluating the complexity of signals at the multiple time scales inherent in physiologic dynamics, we find that healthy subjects show more complex time series at large time scales; on the other hand, at fast time scales, which are more influenced by respiration, the pathologic dynamics of blood pressure is the most random. These results robustly separate healthy and pathologic groups. We also propose a multiscale approach to evaluate interactions between time series, by performing a multivariate autoregressive modelling of the coarse grained time series: this analysis provides several new quantitative indicators which are statistically correlated with the pathology.

  12. Time lag between immigration and tuberculosis rates in immigrants in the Netherlands: a time-series analysis.

    van Aart, C; Boshuizen, H; Dekkers, A; Korthals Altes, H


    In low-incidence countries, most tuberculosis (TB) cases are foreign-born. We explored the temporal relationship between immigration and TB in first-generation immigrants between 1995 and 2012 to assess whether immigration can be a predictor for TB in immigrants from high-incidence countries. We obtained monthly data on immigrant TB cases and immigration for the three countries of origin most frequently represented among TB cases in the Netherlands: Morocco, Somalia and Turkey. The best-fit seasonal autoregressive integrated moving average (SARIMA) model to the immigration time-series was used to prewhiten the TB time series. The cross-correlation function (CCF) was then computed on the residual time series to detect time lags between immigration and TB rates. We identified a 17-month lag between Somali immigration and Somali immigrant TB cases, but no time lag for immigrants from Morocco and Turkey. The absence of a lag in the Moroccan and Turkish population may be attributed to the relatively low TB prevalence in the countries of origin and an increased likelihood of reactivation TB in an ageing immigrant population. Understanding the time lag between Somali immigration and TB disease would benefit from a closer epidemiological analysis of cohorts of Somali cases diagnosed within the first years after entry.

  13. Drought stress release increased growth rate but did not affect levels of storage carbohydrates in Scots pine trees

    Schönbeck, Leonie; Gessler, Arthur; Rigling, Andreas; Schaub, Marcus; Li, Mai-He


    For trees, energy storage in the form of non-structural carbohydrates (NSCs) plays an important role for survival and growth, especially during stress events such as drought. It is hypothesized, that tree individuals that experience long-term drought stress use up larger amounts of NSCs than trees that do not experience drought. Consequently, such drought-induced depletion might lead to a decrease in tree vigor and carbon starvation, a mechanism that is subject of intensive debates in recent literature. Hence, if carbon starvation is occurring during drought, drought stress release should again increase NSC concentrations. A long-term (13 years) irrigation experiment is being conducted in the Pfyn forest, the largest Pinus sylvestris dominated forest in Switzerland, located in the dry inner-Alpine Swiss Rhone valley (average precipitation 600 mm/year, with frequent dry spells). Water addition ( 600 mm/year) is executed every year during the growing season between April and October. Tree height, stem diameter and crown transparency are being measured since 2003. In February, July and October 2015, roots, stem sapwood and needles were harvested from 30 irrigated and 30 control trees and 5 different crown transparency classes. Shoot length, needle morphology, soluble sugars, starch concentrations, needle δ13C and δ15N were measured. Shoot and stem growth were higher in irrigated trees than in control trees. Growth decreased with increasing crown transparency in both treatments. Only in July, needle starch levels were higher in irrigated trees than in control trees but there was no treatment effect for wood and root starch concentrations. Tissue starch and sugar levels were negatively correlated with crown transparency, particularly in the roots (p<0.001), independent of the treatment. Needle δ13C values were higher in the control trees than in the irrigated trees, where needle δ13C values were positively correlated with increasing transparency (p<0.01). Annual

  14. Lyapunov Exponent and Out-of-Time-Ordered Correlator's Growth Rate in a Chaotic System.

    Rozenbaum, Efim B; Ganeshan, Sriram; Galitski, Victor


    It was proposed recently that the out-of-time-ordered four-point correlator (OTOC) may serve as a useful characteristic of quantum-chaotic behavior, because, in the semiclassical limit ℏ→0, its rate of exponential growth resembles the classical Lyapunov exponent. Here, we calculate the four-point correlator C(t) for the classical and quantum kicked rotor-a textbook driven chaotic system-and compare its growth rate at initial times with the standard definition of the classical Lyapunov exponent. Using both quantum and classical arguments, we show that the OTOC's growth rate and the Lyapunov exponent are, in general, distinct quantities, corresponding to the logarithm of the phase-space averaged divergence rate of classical trajectories and to the phase-space average of the logarithm, respectively. The difference appears to be more pronounced in the regime of low kicking strength K, where no classical chaos exists globally. In this case, the Lyapunov exponent quickly decreases as K→0, while the OTOC's growth rate may decrease much slower, showing a higher sensitivity to small chaotic islands in the phase space. We also show that the quantum correlator as a function of time exhibits a clear singularity at the Ehrenfest time t_{E}: transitioning from a time-independent value of t^{-1}lnC(t) at tt_{E}. We note that the underlying physics here is the same as in the theory of weak (dynamical) localization [Aleiner and Larkin, Phys. Rev. B 54, 14423 (1996)PRBMDO0163-182910.1103/PhysRevB.54.14423; Tian, Kamenev, and Larkin, Phys. Rev. Lett. 93, 124101 (2004)PRLTAO0031-900710.1103/PhysRevLett.93.124101] and is due to a delay in the onset of quantum interference effects, which occur sharply at a time of the order of the Ehrenfest time.

  15. Lyapunov Exponent and Out-of-Time-Ordered Correlator's Growth Rate in a Chaotic System

    Rozenbaum, Efim B.; Ganeshan, Sriram; Galitski, Victor


    It was proposed recently that the out-of-time-ordered four-point correlator (OTOC) may serve as a useful characteristic of quantum-chaotic behavior, because, in the semiclassical limit ℏ→0 , its rate of exponential growth resembles the classical Lyapunov exponent. Here, we calculate the four-point correlator C (t ) for the classical and quantum kicked rotor—a textbook driven chaotic system—and compare its growth rate at initial times with the standard definition of the classical Lyapunov exponent. Using both quantum and classical arguments, we show that the OTOC's growth rate and the Lyapunov exponent are, in general, distinct quantities, corresponding to the logarithm of the phase-space averaged divergence rate of classical trajectories and to the phase-space average of the logarithm, respectively. The difference appears to be more pronounced in the regime of low kicking strength K , where no classical chaos exists globally. In this case, the Lyapunov exponent quickly decreases as K →0 , while the OTOC's growth rate may decrease much slower, showing a higher sensitivity to small chaotic islands in the phase space. We also show that the quantum correlator as a function of time exhibits a clear singularity at the Ehrenfest time tE: transitioning from a time-independent value of t-1ln C (t ) at t tE. We note that the underlying physics here is the same as in the theory of weak (dynamical) localization [Aleiner and Larkin, Phys. Rev. B 54, 14423 (1996), 10.1103/PhysRevB.54.14423; Tian, Kamenev, and Larkin, Phys. Rev. Lett. 93, 124101 (2004), 10.1103/PhysRevLett.93.124101] and is due to a delay in the onset of quantum interference effects, which occur sharply at a time of the order of the Ehrenfest time.

  16. Real-time monitoring of inhibitory effects on glutamate-induced neurotransmitter release using a potassium ion image sensor

    Kono, Akiteru; Sakurai, Takashi; Hattori, Toshiaki; Okumura, Koichi; Ishida, Makoto; Sawada, Kazuaki


    To directly image the release of neurotransmitters from neurons, we combined a substance-selective layer with a 128 × 128-pixel ion image sensor based on CMOS technology. Using the substance-specific image sensors, we studied the dynamics of potassium ion ( K+) release from neurons and examined the effect of ouabain on K+ release. K+ transients were significantly inhibited by ouabain. The K+ image sensor used in this study demonstrated the dynamic analysis of ligand-operated signal release and the pharmacological assessment of secretagogues without requiring cell labeling.

  17. Increased rate change over time of a sphincter-saving procedure for lower rectal cancer

    WU Xiao-jian; WANG Jian-ping; WANG Lei; HE Xiao-sheng; ZOU Yi-feng; LIAN Lei; ZHANG Long-juan; LAN Ping


    Background Total mesorectal excision(TME)has increased the rate of sphincter-preservation(SP)for more patients with low-lying rectal cancer.Here,we analyze the change of sphincter preserving rates in lower rectal cancer and their related factors.Methods We reviewed retrospectively the medical records of 316 patients with lower rectal cancers,1 to 5 cm from the anorectal line,who had surgical resections from August 1994 to November 2005.The 12-year span was divided into 2 periods:period Ⅰ(August 1994-December 1998)and period Ⅱ(January 1999-November 2005),based on the date (January 1999)when standard total mesorectal excision(TME)was introduced.The patients were divided jnto two groups based on the operation:abdominoperineal resection(APR)or SP surgery.SP rates,leakage and other clinicopathological characteristics were compared between the two time periods and between the two different groups.Results The SP rate increased significantly over the 12 years,from 44.9% in period Ⅰ to 76.2% in period Ⅱ(P=0.000).The factors significantly influencing SP included the distance of the tumor from the anorectal line,gender,time period,circumference of intramural spread and histological differentiation (P<0.05).Significant differences were detected between the two time periods in gender,blood transfusion volume and Dukes'stage(P<0.05).The leakage rate was 2.7% in period Ⅰ and 1.3% in period Ⅱ (P>0.05).Conclusions Over the 12-year period of the study the SP rate in rectal cancers 1-5 cm from the anorectal line has increased significantly while the blood transfusion volume has decreased due to the introduction of TME.However,TME had no effect on operating time and leakage rates.

  18. Quality of life in mild dementia: patterns of change in self and caregiver ratings over time

    Marcia C. Dourado


    Full Text Available Objectives: To determine changes over time in self and caregiver ratings of quality of life (QoL in people with dementia (PwD and to identify factors associated with changes in QoL ratings. Methods: In this longitudinal study, 69 people with mild Alzheimer’s disease and their caregivers were assessed at baseline and after 1 year. We examined the association of QoL ratings with the following variables at the two time points: awareness of disease, cognitive status, mood, functionality, neuropsychiatric symptoms, and caregiver burden. Multivariate regression analyses were conducted to examine the contribution of co-factors. Results: At baseline, PwD self-ratings of QoL were associated with caregiver ratings of PwD QoL (p = 0.001. Caregiver ratings were associated with PwD mood (p = 0.001 and self-rated QoL (p = 0.001. After 1 year, caregiver ratings of PwD QoL changed significantly (p = 0.049, d = -0.27, whereas PwD self-ratings did not (p = 0.89, d = 0.09. PwD awareness of disease changed significantly (p = 0.001 at 1 year, having declined in 25.4% and improved in 12.3% of participants. PwD QoL self-ratings were associated with caregiver ratings (p = 0.001. Caregiver ratings of PwD QoL after 1 year were associated with PwD mood (p = 0.029, self-reported QoL (p = 0.001, and awareness of disease (p = 0.033. Conclusions: The association between self and caregiver ratings of PwD QoL was maintained over 1 year. The primary factors accounting for the change in caregiver ratings were PwD mood and awareness of disease. QoL and cognitive impairment seem to be relatively independent in mild dementia.

  19. 近红外透射光谱法快速测定布洛芬缓释胶囊释放度%Rapid determination of ibuprofen sustained-release capsule releasing rate using near infrared transmission spectroscopy technology

    王小亮; 贾建忠; 杨欣; 刘雪峰


    目的:利用近红外透射光谱分析技术和化学计量学方法对布洛芬缓释胶囊释放度进行快速定量分析.方法:以30批布洛芬缓释胶囊为分析对象,首先用近红外透射光谱法采集不同时间段释放液的近红外透射光谱,并以高效液相色谱法测定其含量,最后采用偏最小二乘法建立释放度定量测定模型.结果:30批布洛芬缓释胶囊释放度实验得到101个样品数据,采用外部验证建立模型.根据自动分离原理,从101个样品数据中选择了61个数据作为校正集样本,含量范围为4.97%~30.89%;剩余40个数据作为验证集样本,含量范围为5.07% ~30.34%;建模谱段为8937 ~7487 cm-1及6102 ~5446 cm-1;预处理方法为一阶导加多元散射校正;维数为6;内部验证及外部验证的相关系数分别为95.04%和94.37%;内部交叉验证及外部验证均方根误差分别为1.96%和2.04%.结论:所建立的释放度快速分析定量模型可对布洛芬制剂进行准确、快速定量分析,方法快速简便,可用于药品的快速分析和检验.%Objective: To quantitatively analyze the releasing rate of ibuprofen sustained - release capsules by near infrared transmission spectroscopy technology and chemometrics. Methods:A total of 30 batches of ibuprofen sustained - release capsules were chosen for analysis. First,the near infrared spectrum of the releasing liquid of ibuprofen sustained -release capsules was collected in different periods. Then,the active pharmaceutical ingredient(API) contents were determined by HPLC. Finally, the releasing rate quantitative model with the partial least square { PLS) algorithm available in the Quant 2 was developed. Results:Our model was based on 101 data obtained from 30 batches of samples, which included 61 data in calibration set with the API ranged from 4. 97% - 30. 89% , and 40 data in test set with the API from 5.07% - 30. 34% . The spectra ranges were 8937 - 7487 cm-1

  20. Optimal harvesting of fish stocks under a time-varying discount rate.

    Duncan, Stephen; Hepburn, Cameron; Papachristodoulou, Antonis


    Optimal control theory has been extensively used to determine the optimal harvesting policy for renewable resources such as fish stocks. In such optimisations, it is common to maximise the discounted utility of harvesting over time, employing a constant time discount rate. However, evidence from human and animal behaviour suggests that we have evolved to employ discount rates which fall over time, often referred to as "hyperbolic discounting". This increases the weight on benefits in the distant future, which may appear to provide greater protection of resources for future generations, but also creates challenges of time-inconsistent plans. This paper examines harvesting plans when the discount rate declines over time. With a declining discount rate, the planner reduces stock levels in the early stages (when the discount rate is high) and intends to compensate by allowing the stock level to recover later (when the discount rate will be lower). Such a plan may be feasible and optimal, provided that the planner remains committed throughout. However, in practice there is a danger that such plans will be re-optimized and adjusted in the future. It is shown that repeatedly restarting the optimization can drive the stock level down to the point where the optimal policy is to harvest the stock to extinction. In short, a key contribution of this paper is to identify the surprising severity of the consequences flowing from incorporating a rather trivial, and widely prevalent, "non-rational" aspect of human behaviour into renewable resource management models. These ideas are related to the collapse of the Peruvian anchovy fishery in the 1970's. Copyright © 2010 Elsevier Ltd. All rights reserved.

  1. Growth rates of atmospheric molecular clusters determined from cluster appearance times and collision-evaporation fluxes

    Kontkanen, Jenni; Olenius, Tinja; Lehtipalo, Katrianne; Vehkamäki, Hanna; Kulmala, Markku


    The probability of freshly formed particles to survive to climatically relevant sizes is determined by the competition between the coagulation loss rate and the particle growth rate. Therefore, various methods have been developed to deduce the growth rates from measured particle size distributions. Recently, the growth rates of sub-3nm clusters have been determined based on the appearance times of different cluster sizes. However, it is not clear to what extent these growth rates are consistent with the growth rates corresponding to molecular fluxes between clusters. In this work, we simulated the time evolution of a population of sub-3 nm molecular clusters and compared the growth rates determined (1) from the cluster appearance times and (2) from the collision-evaporation fluxes between different cluster sizes. We performed a number of simulations by varying the ambient conditions and the properties of the model substance. In the first simulation set, the Gibbs free energy of the formation of the clusters was assumed to have a single maximum and no minima, corresponding to a monotonically increasing stability as a function of cluster size. The saturation vapor pressure was selected so that the growth proceeded solely via monomer additions. The growth rates were determined separately for each cluster. However, to see the effect of finite size resolution, we also performed simulations where the clusters were grouped into size bins, for which we determined the growth rates. In the second simulation set, the saturation vapor pressure was lowered so that the collisions of small clusters significantly contributed to the growth. As the growth rate of a single cluster is ambiguous in this case, the growth rates were determined only for different size bins. We performed simulations using a similar free energy profile as in other simulations but we also used a free energy profile containing a local minimum, corresponding to small stable clusters. Our simulations show that

  2. Time series analyses reveal environmental and fisheries controls on Atlantic horse mackerel (Trachurus trachurus) catch rates

    Leitão, Francisco


    Time-series models (Dynamic factorial analyses and; Min/max autocorrelation factor analysis) were used to explore the relative influences of environmental variables and fishing pressure of trawl, seine and artisanal fleets on catch rates on Trachurus trachurus in ICES IXa sub-divisions (IXaCN-North coast; IXa- CS-South coast; IXaS-Algarve, South coast, Algarve). Fishing effort influenced catch rates in all areas with a 2 year lag and fishing pressure for each area was related to specific fleet sectors effort. In IXaCN, winter upwelling (spawning peak) and both summer northerly wind and wind magnitude (outside of the spawning peak) were strongly correlated with catch rates. In IXaCS summer/autumn westerly winds were related with catch rates. Northerly winds in spring, upwelling and SST (winter and autumn) were related with catch rates in IXaS-Algarve. For species with a long spawning season such as horse mackerel, seasonal analyses at broad regional scales can detract from a better understanding of variability in short term sub-stock catch rates. Favorable environmental conditions, even during seasons with low spawning activity can positively affect catch rates. Ignoring the role of regional oceanographic features on the spatial distribution of the sub-stocks when analysing variability in catch rates can lead to poor inferences about the productivity of the populations.

  3. Heterogeneity of rat FSH by chromatofocusing: studies on serum FSH, hormone released in vitro and metabolic clearance rates of its various forms.

    Blum, W F; Gupta, D


    Rat pituitary FSH was fractionated by chromatofocusing between pH 6 and 3. Ten components were resolved having apparent isoelectric points between 3.1 and 5.1. A comparative study of pituitary FSH and FSH secreted in vitro by quartered pituitary glands in the presence and in the absence of gonadotrophin-releasing hormone (GnRH) revealed similar patterns of charged species of intracellular and released FSH. Although GnRH increased FSH secretion about fourfold, no influence on the pattern of charged species was observed. Utilizing exclusion chromatography and chromatofocusing, pituitary FSH was compared to serum FSH which had been extracted by immuno-affinity chromatography. The results demonstrate for serum FSH a larger molecular size and a relative shift to more acidic components. Metabolic clearance rates of eight FSH components separated by chromatofocusing were measured in adult male rats. Half-lives varied between 13 min and several hours. A correlation existed between decrease of isoelectric points and decrease of metabolic clearance rates. These findings suggest that all hypophysial FSH components are secreted into the circulation at similar rates and the more acidic FSH components which appear to contain increased sialic acid, have a longer circulatory half-life and are more abundant in serum. It is concluded that sialylation may be involved in modulating serum FSH levels.

  4. Comparative evaluation of the calcium release from mineral trioxide aggregate and its mixture with glass ionomer cement in different proportions and time intervals – An in vitro study

    Surbhi Sawhney


    Conclusions: Adding GIC to improve the setting time and handling properties of the MTA powder can be detrimental to the calcium-releasing ability of the resultant mixture, depending on the proportion of GIC added. Adding MTA and GIC at a proportion of 2:1 by volume did not impact calcium release from the mixture. These findings should be verified through further clinical studies.

  5. Controlled-release microchips.

    Sharma, Sadhana; Nijdam, A Jasper; Sinha, Piyush M; Walczak, Robbie J; Liu, Xuewu; Cheng, Mark M-C; Ferrari, Mauro


    Efficient drug delivery remains an important challenge in medicine: continuous release of therapeutic agents over extended time periods in accordance with a predetermined temporal profile; local delivery at a constant rate to the tumour microenvironment to overcome much of the systemic toxicity and to improve antitumour efficacy; improved ease of administration, and increasing patient compliance required are some of the unmet needs of the present drug delivery technology. Microfabrication technology has enabled the development of novel controlled-release microchips with capabilities not present in the current treatment modalities. In this review, the current status and future prospects of different types of controlled-release microchips are summarised and analysed with reference to microneedle-based microchips, as well as providing an in-depth focus on microreservoir-based and nanoporous microchips.

  6. Aptamer/Graphene Quantum Dots Nanocomposite Capped Fluorescent Mesoporous Silica Nanoparticles for Intracellular Drug Delivery and Real-Time Monitoring of Drug Release.

    Zheng, Fen-Fen; Zhang, Peng-Hui; Xi, Yu; Chen, Jing-Jia; Li, Ling-Ling; Zhu, Jun-Jie


    Great challenges in investigating the release of drug in complex cellular microenvironments necessitate the development of stimuli-responsive drug delivery systems with real-time monitoring capability. In this work, a smart drug nanocarrier based on fluorescence resonance energy transfer (FRET) is fabricated by capping graphene quantum dots (GQDs, the acceptor) onto fluorescent mesoporous silica nanoparticles (FMSNs, the donor) via ATP aptamer for real-time monitoring of ATP-triggered drug release. Under extracellular conditions, the fluorescence of FMSNs remains in the "off" state in the low ATP level which is unable to trigger the release of drug. Once specifically recognized and internalized into the target tumor cells by AS1411 aptamer, in the ATP-rich cytoplasm, the conformation switch of the ATP aptamer causes the shedding of the GQDs from the nanocarriers, leading to the release of the loaded drugs and consequently severe cytotoxicity. Simultaneously, the fluorescence of FMSNs turns "on" along with the dissociation of GQDs, which allows real-time monitoring of the release of drug from the pores. Such a drug delivery system features high specificity of dual-target recognition with AS1411 and ATP aptamer as well as high sensitivity of the FRET-based monitoring strategy. Thus, the proposed multifunctional ATP triggered FRET-nanocarriers will find potential applications for versatile drug-release monitoring, efficient drug transport, and targeted cancer therapeutics.

  7. The relative efficiency of time-to-threshold and rate of change in longitudinal data.

    Donohue, M C; Gamst, A C; Thomas, R G; Xu, R; Beckett, L; Petersen, R C; Weiner, M W; Aisen, P


    Randomized, placebo-controlled trials often use time-to-event as the primary endpoint, even when a continuous measure of disease severity is available. We compare the power to detect a treatment effect using either rate of change, as estimated by linear models of longitudinal continuous data, or time-to-event estimated by Cox proportional hazards models. We propose an analytic inflation factor for comparing the two types of analyses assuming that the time-to-event can be expressed as a time-to-threshold of the continuous measure. We conduct simulations based on a publicly available Alzheimer's disease data set in which the time-to-event is algorithmically defined based on a battery of assessments. A Cox proportional hazards model of the time-to-event endpoint is compared to a linear model of a single assessment from the battery. The simulations also explore the impact of baseline covariates in either analysis.

  8. High-Rate Fast-Time GRPC for the high eta CMS muon detectors

    Mirabito, Laurent


    CMS detector. In their single-gap version we will show that they can stand rates of few ${\\rm kHz/cm}^2$. We also demonstrate that using multi-gap glass RPC, a time resolution of about 60 ps is achieved.

  9. Response-Time Variability Is Related to Parent Ratings of Inattention, Hyperactivity, and Executive Function

    Gomez-Guerrero, Lorena; Martin, Cristina Dominguez; Mairena, Maria Angeles; Di Martino, Adriana; Wang, Jing; Mendelsohn, Alan L.; Dreyer, Benard P.; Isquith, Peter K.; Gioia, Gerard; Petkova, Eva; Castellanos, F. Xavier


    Objective: Individuals with ADHD are often characterized as inconsistent across many contexts. ADHD is also associated with deficits in executive function. We examined the relationships between response time (RT) variability on five brief computer tasks to parents' ratings of ADHD-related features and executive function in a group of children with…

  10. Index for Evaluating Heart Rate Variability based on the Extreme Point of Time Series

    Yoshida, Yutaka; Yokoyama, Kiyoko; Ishii, Naohiro

    In this study, it aimed at the proposal of real time and continuous estimating method of physiological states using biological signals. The proposal method will be one of the basic technology to develop physiological state monitor. The proposal index is defined in the ratio of the number of extreme points of the heart rate time series and the number of heart rate. This index is called NEP. The characteristic of the NEP was shown by simulation analysis. The NEP was compared with classical indices of heart rate variability by the analysis of measured heart rate time series. NEP decreased significantly (p<0.05) when posture changed from supine to standing. In this case, the autonomic nervous activity balance changes from the parasympathetic to the sympathetic nerve. Moreover, the NEP was correlated with the respiratory frequency in supine position (p<0.01). It is not necessary to consider individual variation of NEP in the physiological state evaluation. Standardization process or relative value is not necessary to compare individual persons. This parameter is applicable to evaluate physiological state at real time and continuously.

  11. Prohexadione rate and timing effects on alfalfa interseeded into silage corn

    Prohexadione-Ca (PHD) can enhance establishment of alfalfa (Medicago sativa, L.) interseeded into silage corn (Zea mays, L.), but optimal application rates and timing for this growth regulator are unknown. Two experiments examined how single or split applications of 0.25 to 1.0 kg a.i. ha-1 of PHD o...

  12. The rate, luminosity function and time delay of non-Collapsar short GRBs

    Wanderman, David


    We estimate the rate and the luminosity function of short (hard) Gamma-Ray Bursts (sGRBs) that are non-Collapsars, using the peak fluxes and redshifts of BATSE, Swift and Fermi GRBs. Following \\cite{Bromberg2013} we select a sub-sample of \\swift bursts which are most likely non-Collapsars. We find that these sGRBs are delayed relative to the global star formation rate (SFR) with a typical delay time of a $2.9^{+0.4}_{-0.4} $~Gyr or $3.9^{+0.4}_{-0.5}$ (depending on the SFR model). The current event rate of these non-Collapsar sGRBs with $L_{iso}>5\\times 10^{49} erg/s$ is $4.1_{-1.9}^{+2.3}Gpc^{-3}yr^{-1}$. The rate was significantly larger around $z \\sim 1$ and it declines since that time. The luminosity function we find is a broken power law with a break at $2.0_{-0.4}^{+1.4} \\times 10^{52}$~erg/s and power-law indices $0.95_{-0.1 2}^{+0.12}$ and $2.0_{-0.8}^{+1.0}$. When considering the whole \\swift sGRB sample we find that it is composed of two populations: One group ($\\approx 60\\%-80\\%$ of \\swift sGRBs) o...

  13. Norway and adjacent sedimentary basins during Cenozoic times - sediment fluxes, accumulation rates and mass balance

    Gołędowski, Bartosz; Nielsen, S.B.; Clausen, O.R.


    is in agreement with the so-called ICE hypothesis (Nielsen et al., 2009) which suggests the longevity of the Scandinavian mountains and do not impose tectonic rejuvenation of topography in Cenozoic times. Such episodes of tectonic uplift have been previously suggested as the controlling factors of erosion rates...

  14. Real Time Quantification of Ultrafast Photoinduced Bimolecular Electron Transfer Rate: Direct Probing of the Transient Intermediate.

    Mukherjee, Puspal; Biswas, Somnath; Sen, Pratik


    Fluorescence quenching studies through steady-state and time-resolved measurements are inadequate to quantify the bimolecular electron transfer rate in bulk homogeneous solution due to constraints from diffusion. To nullify the effect of diffusion, direct evaluation of the rate of formation of a transient intermediate produced upon the electron transfer is essential. Methyl viologen, a well-known electron acceptor, produces a radical cation after accepting an electron, which has a characteristic strong and broad absorption band centered at 600 nm. Hence it is a good choice to evaluate the rate of photoinduced electron transfer reaction employing femtosecond broadband transient absorption spectroscopy. The time constant of the aforementioned process between pyrene and methyl viologen in methanol has been estimated to be 2.5 ± 0.4 ps using the same technique. The time constant for the backward reaction was found to be 14 ± 1 ps. These values did not change with variation of concentration of quencher, i.e., methyl viologen. Hence, we can infer that diffusion has no contribution in the estimation of rate constants. However, on changing the solvent from methanol to ethanol, the time constant of the electron transfer reaction has been found to increase and has accounted for the change in solvent reorganization energy.

  15. The Limit Behavior of a Stochastic Logistic Model with Individual Time-Dependent Rates

    Yilun Shang


    Full Text Available We investigate a variant of the stochastic logistic model that allows individual variation and time-dependent infection and recovery rates. The model is described as a heterogeneous density dependent Markov chain. We show that the process can be approximated by a deterministic process defined by an integral equation as the population size grows.

  16. Time Series Studies on Indonesian Rupiah/USD Rate: 1995-2005

    A.V. Hardiyanto


    textabstractThe exchange rate of Rp/USD has experienced three regimes since 1967: fixed, managed float, and free float. During the period of 1967 – 1986, Rp/USD was devalued for 8 times by the authority to help maintain the external balance. The devaluations were part of the expenditure switching po

  17. The control of self-propelled microjets inside a microchannel with time-varying flow rates

    Khalil, Islam S.M.; Magdanz, Veronika; Sanchez, Samuel; Schmidt, Oliver S.; Misra, Sarthak


    We demonstrate the closed-loop motion control of self-propelled microjets inside a fluidic microchannel. The motion control of the microjets is achieved in hydrogen peroxide solution with time-varying flow rates, under the influence of the controlled magnetic fields and the self-propulsion force. Ma

  18. The ruin probability of a discrete time risk model under constant interest rate with heavy tails

    Tang, Q.


    This paper investigates the ultimate ruin probability of a discrete time risk model with a positive constant interest rate. Under the assumption that the gross loss of the company within one year is subexponentially distributed, a simple asymptotic relation for the ruin probability is derived and co

  19. Time utilization rate (TUR) of NTI-PGDE Students in self-study: the ...

    Time utilization rate (TUR) of NTI-PGDE Students in self-study: the case of Port Harcourt ... Diploma in Education (PGDE) students of the National Teachers' Institute. ... in self-study since that is mainly the mode of study in the Distance Learning ...

  20. High-Rate Fast-Time GRPC for the high eta CMS muon detectors

    Mirabito, Laurent


    CMS detector. In their single-gap version we will show that they can stand rates of few ${\\rm kHz/cm}^2$. We also demonstrate that using multi-gap glass RPC, a time resolution of about 60 ps is achieved.

  1. Real-time Continuous Assessment Method for Mental and Physiological Condition using Heart Rate Variability

    Yoshida, Yutaka; Yokoyama, Kiyoko; Ishii, Naohiro

    It is necessary to monitor the daily health condition for preventing stress syndrome. In this study, it was proposed the method assessing the mental and physiological condition, such as the work stress or the relaxation, using heart rate variability at real time and continuously. The instantanuous heart rate (HR), and the ratio of the number of extreme points (NEP) and the number of heart beats were calculated for assessing mental and physiological condition. In this method, 20 beats heart rate were used to calculate these indexes. These were calculated in one beat interval. Three conditions, which are sitting rest, performing mental arithmetic and watching relaxation movie, were assessed using our proposed algorithm. The assessment accuracies were 71.9% and 55.8%, when performing mental arithmetic and watching relaxation movie respectively. In this method, the mental and physiological condition was assessed using only 20 regressive heart beats, so this method is considered as the real time assessment method.



    Space-Time Block (STB) code has been an effective transmit diversity technique for combating fading due to its orthogonal design, simple decoding and high diversity gains. In this paper, a unit-rate complex orthogonal STB code for multiple antennas in Time Division Duplex (TDD) mode is proposed. Meanwhile, Turbo Coding (TC) is employed to improve the performance of proposed STB code further by utilizing its good ability to combat the burst error of fading channel. Compared with full-diversity multiple antennas STB codes, the proposed code can implement unit rate and partial diversity; and it has much smaller computational complexity under the same system throughput. Moreover, the application of TC can effectively make up for the performance loss due to partial diversity. Simulation results show that on the condition of same system throughput and concatenation of TC, the proposed code has lower Bit Error Rate (BER) than those full-diversity codes.

  3. Simulation of biochemical reactions with time-dependent rates by the rejection-based algorithm

    Thanh, Vo Hong, E-mail: [The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Piazza Manifattura 1, Rovereto 38068 (Italy); Priami, Corrado, E-mail: [The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Piazza Manifattura 1, Rovereto 38068 (Italy); Department of Mathematics, University of Trento, Trento (Italy)


    We address the problem of simulating biochemical reaction networks with time-dependent rates and propose a new algorithm based on our rejection-based stochastic simulation algorithm (RSSA) [Thanh et al., J. Chem. Phys. 141(13), 134116 (2014)]. The computation for selecting next reaction firings by our time-dependent RSSA (tRSSA) is computationally efficient. Furthermore, the generated trajectory is exact by exploiting the rejection-based mechanism. We benchmark tRSSA on different biological systems with varying forms of reaction rates to demonstrate its applicability and efficiency. We reveal that for nontrivial cases, the selection of reaction firings in existing algorithms introduces approximations because the integration of reaction rates is very computationally demanding and simplifying assumptions are introduced. The selection of the next reaction firing by our approach is easier while preserving the exactness.

  4. Dynamic linear models to explore time-varying suspended sediment-discharge rating curves

    Ahn, Kuk-Hyun; Yellen, Brian; Steinschneider, Scott


    This study presents a new method to examine long-term dynamics in sediment yield using time-varying sediment-discharge rating curves. Dynamic linear models (DLMs) are introduced as a time series filter that can assess how the relationship between streamflow and sediment concentration or load changes over time in response to a wide variety of natural and anthropogenic watershed disturbances or long-term changes. The filter operates by updating parameter values using a recursive Bayesian design that responds to 1 day-ahead forecast errors while also accounting for observational noise. The estimated time series of rating curve parameters can then be used to diagnose multiscale (daily-decadal) variability in sediment yield after accounting for fluctuations in streamflow. The technique is applied in a case study examining changes in turbidity load, a proxy for sediment load, in the Esopus Creek watershed, part of the New York City drinking water supply system. The results show that turbidity load exhibits a complex array of variability across time scales. The DLM highlights flood event-driven positive hysteresis, where turbidity load remained elevated for months after large flood events, as a major component of dynamic behavior in the rating curve relationship. The DLM also produces more accurate 1 day-ahead loading forecasts compared to other static and time-varying rating curve methods. The results suggest that DLMs provide a useful tool for diagnosing changes in sediment-discharge relationships over time and may help identify variability in sediment concentrations and loads that can be used to inform dynamic water quality management.

  5. In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.

    de Witte, Wilhelmus E A; Danhof, Meindert; van der Graaf, Piet H; de Lange, Elizabeth C M


    It is generally accepted that, in conjunction with pharmacokinetics, the first-order rate constant of target dissociation is a major determinant of the time course and duration of in vivo target occupancy. Here we show that the second-order rate constant of target association can be equally important. On the basis of the commonly used mathematical models for drug-target binding, it is shown that a high target association rate constant can increase the (local) concentration of the drug, which decreases the rate of decline of target occupancy. The increased drug concentration can also lead to increased off-target binding and decreased selectivity. Therefore, the kinetics of both target association and dissociation need to be taken into account in the selection of drug candidates with optimal pharmacodynamic properties. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Effect of dairy manure rate and the stabilization time of amended soils on atrazine degradation.

    Aguilera, Paula; Briceño, Gabriela; Candia, Maribel; Mora, Maria de la Luz; Demanet, Rolando; Palma, Graciela


    The application rate of liquid cow manure (LCM) in the field and the stabilization time of amended soils before application of pre-plant herbicides are factors that determine their efficiency. This study includes evaluation of residual atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) in soil and amended soils with equivalent rate of 100,000; 200,000; and 300,000 L ha(-1) of LCM and the effect of pre-incubation time of amended soils on atrazine degradation. The study was carried out under controlled conditions using an Andisol with previous historical application of atrazine. The respiratory activity and fluorescein diacetate (FDA) studies indicated that the time necessary for stabilization of amended soils is over 20-30 d. During the measurement of respiratory and FDA activity, no significant differences were observed when atrazine was applied. The half-life of atrazine ranged from 5 to 8d and the relative distribution of degradation products seem to be affected by the application of LCM. The pre-incubation time of amended soil and LCM dose would not affect atrazine degradation rate, when the soil has a history of herbicide application. However, repeated applications of LCM in a long period of time could change the soil pH and increase the content of dissolved organic carbon (DOC) which could further contribute to a faster degradation of atrazine. Both effects would reduce the effectiveness of atrazine in weed control.

  7. Determination of Optimum Frame Rates for Observation of Construction Operations from Time-Lapse Movies

    Y. M. Ibrahim


    Full Text Available Construction professionals have been using time-lapse movies in monitoring construction operations. However, some amount of detail is always lost in the interval between two consecutive frames in a time-lapse movie. This poses the question: By how much can the frame rate be lowered from the standard 30fps (frames per second to allow for the accurate observation of construction operations from a time-lapse movie? This paper addresses the problem by establishing the optimum frame rates for observation of activities related to mortar mixing and block handling. The activities were first recorded at the standard rate of 30fps. Using the Adobe Premier Pro video editing software, the records were then segregated into still images from which 15 different time-lapse movies of various time intervals were generated. The movies were then shown to 25 Construction Managers. A structured questionnaire was employed to capture the level of accuracy with which Construction Managers could interpret the job site situation from each movie. The results suggest that 1fpm (frame per minute is sufficient for the accurate tracking of labourers involved in mortar mixing while 1 frame in every 20 seconds is sufficient for accurate identification of number of cement bags used. However, for tracking number of blocks off-loaded, and those damaged, 1 frame in every 2 seconds is required.

  8. Single Machine Problem with Multi-Rate-Modifying Activities under a Time-Dependent Deterioration

    M. Huang


    Full Text Available The single machine scheduling problem with multi-rate-modifying activities under a time-dependent deterioration to minimize makespan is studied. After examining the characteristics of the problem, a number of properties and a lower bound are proposed. A branch and bound algorithm and a heuristic algorithm are used in the solution, and two special cases are also examined. The computational experiments show that, for the situation with a rate-modifying activity, the proposed branch and bound algorithm can solve situations with 50 jobs within a reasonable time, and the heuristic algorithm can obtain the near-optimal solution with an error percentage less than 0.053 in a very short time. In situations with multi-rate-modifying activities, the proposed branch and bound algorithm can solve the case with 15 jobs within a reasonable time, and the heuristic algorithm can obtain the near-optimal with an error percentage less than 0.070 in a very short time. The branch and bound algorithm and the heuristic algorithm are both shown to be efficient and effective.

  9. Use of a prototype pulse oximeter for time series analysis of heart rate variability

    González, Erika; López, Jehú; Hautefeuille, Mathieu; Velázquez, Víctor; Del Moral, Jésica


    This work presents the development of a low cost pulse oximeter prototype consisting of pulsed red and infrared commercial LEDs and a broad spectral photodetector used to register time series of heart rate and oxygen saturation of blood. This platform, besides providing these values, like any other pulse oximeter, processes the signals to compute a power spectrum analysis of the patient heart rate variability in real time and, additionally, the device allows access to all raw and analyzed data if databases construction is required or another kind of further analysis is desired. Since the prototype is capable of acquiring data for long periods of time, it is suitable for collecting data in real life activities, enabling the development of future wearable applications.

  10. Nonlinear Least-Squares Time-Difference Estimation from Sub-Nyquist-Rate Samples

    Harada, Koji; Sakai, Hideaki

    In this paper, time-difference estimation of filtered random signals passed through multipath channels is discussed. First, we reformulate the approach based on innovation-rate sampling (IRS) to fit our random signal model, then use the IRS results to drive the nonlinear least-squares (NLS) minimization algorithm. This hybrid approach (referred to as the IRS-NLS method) provides consistent estimates even for cases with sub-Nyquist sampling assuming the use of compactly-supported sampling kernels that satisfies the recently-developed nonaliasing condition in the frequency domain. Numerical simulations show that the proposed NLS-IRS method can improve performance over the straight-forward IRS method, and provides approximately the same performance as the NLS method with reduced sampling rate, even for closely-spaced time delays. This enables, given a fixed observation time, significant reduction in the required number of samples, while maintaining the same level of estimation performance.

  11. Timing of IUI Treatment after hCG Administration 1-48 h Affecting Pregnancy Rate

    Fan YANG; Zu-mei SHI; Hui JIN; Li-ping ZHU; Kun-ming LI; Jian-zhi YANG; Zhi-qin CHEN; Xiao-ming TENG; Hui-fen CHEN; Yu WANG


    Objective To compare the different time of administration of hCG affecting pregnancy rate of IUI. Methods A total of 189 infertile couples underwent 331 cycles of IUI with husband’s sperm.They were separated into 3 groups according to the time of hCG administration in IUI:hCG 1-23 h(group A):hCG 24-36 h (group B);hCG 37—48 h(group C). Results There were no statistical differences among 3 groups.None of the other relative factors,such as the female age,the different methods of ovulation and the cause of infertility,showed differences in pregnancy rate among 3 groups. Conclusion IUI can be performed any time after administration of hCG(1—48 h).

  12. Coarse-grained entropy rates for characterization of complex time series

    Paluš, Milan

    A method for classification of complex time series using coarse grained entropy rates (CER's) is presented. The CER's, which are computed from information-theoretic funcionals - redundancies, are relative measures of regularity and predictability, and for data generated by dynamical systems they are related to Kolmogorov-Sinai entropy. A deterministic dynamical origin of the data under study, however, is not a necessary condition for the use of the CER's, since the entropy rates can be defined for stochastic processes as well. Sensitivity of the CER's to changes in data dynamics and their robustness with respect to noise are tested by using numerically generated time series resulted from both deterministic - chaotic and stochastic processes. Potential application of the CER's in analysis of physiological signals or other complex time series is demonstrated by using examples from pharmaco-EEG and tremor classification.

  13. Timing Analysis of Rate Constrained Traffic for the TTEthernet Communication Protocol

    Tamas-Selicean, Domitian; Pop, Paul; Steiner, Wilfried


    proposed, such as TTEthernet, which is the focus of this paper. TTEthernet is suitable for mixed-criticality systems both in the safety and temporal domain. TTEthernet offers three traffic classes: static time-triggered (TT) traffic, dynamic traffic with bounded transmission rate (called "Rate Constrained......Ethernet is a low-cost communication solution offering high transmission speeds. Although its applications extend beyond computer networking, Ethernet is not suitable for real-time and safety-critical systems. To alleviate this, several real-time Ethernet-based communication protocols have been......", RC), and unbounded dynamic traffic ("Best-Effort", BE). In this paper we propose a novel worst-case end-to-end delay analysis of the RC traffic for TTEthernet systems. The proposed technique considerably reduces the pessimism of the analysis, compared to existing approaches. We have evaluated the new...

  14. Time-Dependent Behaviors of Granite: Loading-Rate Dependence, Creep, and Relaxation

    Hashiba, K.; Fukui, K.


    To assess the long-term stability of underground structures, it is important to understand the time-dependent behaviors of rocks, such as their loading-rate dependence, creep, and relaxation. However, there have been fewer studies on crystalline rocks than on tuff, mudstone, and rock salt, because the high strength of crystalline rocks makes the detection of their time-dependent behaviors much more difficult. Moreover, studies on the relaxation, temporal change of stress and strain (TCSS) conditions, and relations between various time-dependent behaviors are scarce for not only granites, but also other rocks. In this study, previous reports on the time-dependent behaviors of granites were reviewed and various laboratory tests were conducted using Toki granite. These tests included an alternating-loading-rate test, creep test, relaxation test, and TCSS test. The results showed that the degree of time dependence of Toki granite is similar to other granites, and that the TCSS resembles the stress-relaxation curve and creep-strain curve. A viscoelastic constitutive model, proposed in a previous study, was modified to investigate the relations between the time-dependent behaviors in the pre- and post-peak regions. The modified model reproduced the stress-strain curve, creep, relaxation, and the results of the TCSS test. Based on a comparison of the results of the laboratory tests and numerical simulations, close relations between the time-dependent behaviors were revealed quantitatively.

  15. Fission-product energy release for times following thermal-neutron fission of /sup 235/U between 2 and 14000 seconds

    Dickens, J.K.; Emery, J.F.; Love, T.A.; McConnell, J.W.; Northcutt, K.J.; Peelle, R.W.; Weaver, H.


    Fission-product decay energy-releases rates were measured for thermal-neutron fission of /sup 235/U. Samples of mass 1 to 10 were irradiated for 1 to 100 sec by use of the fast pneumatic-tube facility at the Oak Ridge Research Reactor. The resulting beta- and gamma-ray emissions were counted for times-after-fission between 2 and 14,000 seconds. The data were obtained for beta and gamma rays separately as spectral distributions, N(E/sub ..gamma../) vs E/sub ..gamma../ and N(E/sub beta/) vs E/sub ..beta../. For the gamma-ray data the spectra were obtained by using a NaI detector, while for the beta-ray data the spectra were obtained by using an NE-110 detector with an anticoincidence mantle. The raw data were unfolded to provide spectral distributions of modest resolution. These were integrated over E/sub ..gamma../ and E/sub ..beta../ to provide total yield and energy integrals as a function of time after fission. Results are low compared to the present 1973 ANS Decay-heat standard. A complete description of the experimental apparatus and data-reduction techniques is presented. The final integral data are given in tabular and graphical form and are compared with published data. 41 figures, 13 tables.

  16. Estimation of Saturation Flow Rate and Start-Up Lost Time for Signal Timing Based on Headway Distribution

    Yi Zhao


    Full Text Available This study aimed to calibrate saturation flow rate (SFR and start-up lost time (SLT when developing signal timing. In current commonly used methods, SFR for one given lane is usually calibrated from many subjective adjustment factors and a fixed result. SLT is calculated based on the fixed SFR, which prevents local applications in China. Considering the importance of traffic behavior (headway in determining SFR and SLT, this study started from headway distribution and attempted to specify the relationships between headway and vehicle position directly. A common intersection in Nanjing, China, was selected to implement field study and data from 920 queues was collected. Headway distribution was explored and the 78th percentile of headway at each position was selected to build model. Based on the developed relationships, SFR and SLT were calibrated. The results showed that SFR and SLT were correlated with queue length. Moreover, the results showed that it was difficult to reach saturated state even with a long queue length. This paper provides a new perspective on calibrating important parameters in signal timing, which will be useful for traffic agencies to complete signal timing by making the process simpler.

  17. A Bayesian framework to estimate diversification rates and their variation through time and space

    Silvestro Daniele


    Full Text Available Abstract Background Patterns of species diversity are the result of speciation and extinction processes, and molecular phylogenetic data can provide valuable information to derive their variability through time and across clades. Bayesian Markov chain Monte Carlo methods offer a promising framework to incorporate phylogenetic uncertainty when estimating rates of diversification. Results We introduce a new approach to estimate diversification rates in a Bayesian framework over a distribution of trees under various constant and variable rate birth-death and pure-birth models, and test it on simulated phylogenies. Furthermore, speciation and extinction rates and their posterior credibility intervals can be estimated while accounting for non-random taxon sampling. The framework is particularly suitable for hypothesis testing using Bayes factors, as we demonstrate analyzing dated phylogenies of Chondrostoma (Cyprinidae and Lupinus (Fabaceae. In addition, we develop a model that extends the rate estimation to a meta-analysis framework in which different data sets are combined in a single analysis to detect general temporal and spatial trends in diversification. Conclusions Our approach provides a flexible framework for the estimation of diversification parameters and hypothesis testing while simultaneously accounting for uncertainties in the divergence times and incomplete taxon sampling.

  18. TR-BREATH: Time-Reversal Breathing Rate Estimation and Detection.

    Chen, Chen; Han, Yi; Chen, Yan; Lai, Hung-Quoc; Zhang, Feng; Wang, Beibei; Liu, K J Ray


    In this paper, we introduce TR-BREATH, a timereversal (TR) based contact-free breathing monitoring system. It is capable of breathing detection and multi-person breathing rate estimation within a short period of time using off-the-shelf WiFi devices. The proposed system exploits the channel state information (CSI) to capture the miniature variations in the environment caused by breathing. To magnify the CSI variations, TRBREATH projects CSIs into the TR resonating strength (TRRS) feature space and analyzes the TRRS by the Root-MUSIC and affinity propagation algorithms. Extensive experiment results indoor demonstrate a perfect detection rate of breathing. With only 10 seconds of measurement, a mean accuracy of 99% can be obtained for single-person breathing rate estimation under the non-line-of-sight (NLOS) scenario. Furthermore, it achieves a mean accuracy of 98:65% in breathing rate estimation for a dozen people under the line-of-sight (LOS) scenario and a mean accuracy of 98:07% in breathing rate estimation of 9 people under the NLOS scenario, both with 63 seconds of measurement. Moreover, TR-BREATH can estimate the number of people with an error around 1. We also demonstrate that TR-BREATH is robust against packet loss and motions. With the prevailing of WiFi, TR-BREATH can be applied for in-home and real-time breathing monitoring.

  19. [Nitrogen uptake rate and use efficiency by rice under different levels of the controlled-release N fertilizers (CRF) in the Nansi Lake basin].

    Zhang, Qing-Wen; Du, Chun-Xiang; Li, Xiao-Wei; Li, Gui-Chun; Wang, Ming


    The nitrogen (N) fertilizers overused or misused are the main contributors for water eutrophication of the Nansi Lake in eastern China. A field experiment with different application levels of controlled-release N fertilizer (CRF) was carried out at a rice field in the Nansi lake basin to provide information on the nitrogen uptake rate and use efficiency by rice with CRF application at different growth stages of rice. The fertilization levels for the controlled fertilizer in this study were 0, 300, 337.5 and 375 kg/hm2, respectively, and 375 kg/hm2 for conventional urea (CU). We estimated the N uptake rate in different growing season and apparent recovery of fertilizer in root, stover and grain of rice. The result showed that grain yield increased by higher N rate. However, the N uptake rate did not increase linearly with the nitrogen application amount. The highest N uptake rate was 22.48 mg/(plant x d) under the fertilization amount of 337.5 kg/hm2 during the young panicle differentiation stage. Apparent N recovery efficiency for CU with traditional application amount of 375 kg/hm2 was 21.86%. Apparent N recovery efficiency for CRF with application amount of 337.5 kg/hm2 was highest with 37.17%. Based on the statistical data, with CU of traditional urea application amount of 375 kg/hm2, nitrogen loss and soil N residue at one growing season are 130.07 x 10(3) t for Jining city and 11.4 x 10(3) t for Yutai county of the Nansi Lake basin. If using CRF with the optimized application amount of 337.5 kg/hm2, nitrogen loss and soil residual at one growing season is 10.46 x 10(4) t for Jining city. It could reduce losses of 2.55 x 10(4) t N for Jining city and 2 235.26 t N for Yutai county per year. Because of releasing patterns more closely matched to crop N uptake patterns, controlled release N fertilizer could be a good way to prevent water eutrophication due to nitrogen fertilizer overused or misused in the Nansi Lake.




    Full Text Available This paper discusses the combustion propensity of single cylinder direct injection engine fueled with palm kernel methyl ester (PKME, which is non- edible oil and a secondary co-injection of saturated Diethyl ether (DEE with water. DEE along with water is fumigated through a high pressure nozzle fitted to the inlet manifold of the engine and the flow rate of the secondary injection was electronically controlled. DEE is known to improve the cold starting problem in engines when used in straight diesel fuel. However, its application in emulsion form is little known. Experimental results show that for 5% DEE- H2O solution injection, occurrence of maximum net heat release rate is delayed due to controlled premixed combustion, which normally helped in better torque conversion when the piston is in accelerated mode. Vibration measurements in the frequency range of 900Hz to 1300Hz revealed that a new mode of combustion has taken place with different excitation frequencies.

  1. Corrosion studies with high burnup light water reactor fuel. Release of nuclides into simulated groundwater during accumulated contact time of up to two years

    Zwicky, Hans-Urs (Zwicky Consulting GmbH, Remigen (Switzerland)); Low, Jeanett; Ekeroth, Ella (Studsvik Nuclear AB, Nykoeping (Sweden))


    period, water samples are taken for different analyses and for pH and carbonate determination. The fuel sample is placed in a new flask with fresh synthetic groundwater for the next contact period. Release fractions are calculated by dividing the total amount of a nuclide of concern in the analysed solution by the total amount in the corroded fuel sample. Cumulative release fractions are the sum of release fractions up to a certain cumulative contact time. Release rates are calculated by dividing release fractions by the length of the contact period of concern. Caesium and rubidium were released to a significantly larger extent in the high burnup samples, compared to the Series 11 experiments. This is probably more a consequence of different operating conditions than of burnup

  2. Mass flow-rate control through time periodic electro-osmotic flows in circular microchannels

    Chakraborty, Suman; Ray, Subhashis


    The present study is directed towards devising a scientific strategy for obtaining controlled time-periodic mass flow-rate characteristics through the employment of pulsating electric fields in circular microchannels by exploiting certain intrinsic characteristics of periodic electro-osmosis phenomenon. Within the assumption of thin electrical double layers, the governing equations for potential distribution and fluid flow are derived, corresponding to a steady base state and a time-varying perturbed state, by assuming periodic forms of the imposed electrical fields and the resultant velocity fields. For sinusoidal pulsations of the electric field superimposed over its mean, a signature map depicting the amplitudes of the mass flow rate and the electrical field as well as their phase differences is obtained from the theoretical analysis as a function of a nondimensional frequency parameter for different ratios of the characteristic electric double layer thickness relative to the microchannel radius. Distinctive characteristics in the signature profiles are obtained for lower and higher frequencies, primarily attributed to the finite time scale for momentum propagation away from the walls. The signature characteristics, obtained from the solution of the prescribed sinusoidal electric field, are subsequently used to solve the "inverse" problem, where the mass flow rate is prescribed in the form of sinusoidal pulsations and the desired electric fields that would produce the required mass flow-rate variations are obtained. The analysis is subsequently extended for controlled triangular and trapezoidal pulsations in the mass flow rate and the required electric fields are successfully obtained. It is observed that the higher the double layer thickness is in comparison to the channel radius, the more prominent is the deviation of the shape of the required electric field pulsation from the desired transience in the mass flow-rate characteristics. Possible extensions of the

  3. Sleep Duration and “on” Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release

    Heinz Reichmann


    Full Text Available Patients undergoing long-term therapy for PD often experience motor fluctuations and nocturnal disturbances. In a post-hoc analysis, we explored effects of ropinirole prolonged release on sleep, night-time awakenings, and “on” time over 24 hours. Patients with advanced PD suboptimally controlled with L-dopa were randomized to adjunctive ropinirole prolonged release (2–24 mg/day or placebo for 24 weeks. Awake/asleep and, if awake, “on”/“off” status was recorded via diary cards. At week 24 last observation carried forward, changes in nighttime or daytime sleep duration were not significantly different between treatments. Of patients with baseline awakenings, a significantly higher proportion in the ropinirole prolonged release group had a reduction in awakenings versus placebo. Patients receiving ropinirole prolonged release had a significantly greater increase in amount/percentage of awake time “on”/“on” without troublesome dyskinesia during all periods assessed (including night-time and early morning, versus placebo, and higher odds for being “on” on waking. Adjunctive once-daily ropinirole prolonged release may help provide 24-hour symptom control in patients with advanced PD not optimally controlled with L-dopa.

  4. Sleep Duration and “on” Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release

    Reichmann, Heinz; Cooper, James; Rolfe, Katie; Martinez-Martin, Pablo


    Patients undergoing long-term therapy for PD often experience motor fluctuations and nocturnal disturbances. In a post-hoc analysis, we explored effects of ropinirole prolonged release on sleep, night-time awakenings, and “on” time over 24 hours. Patients with advanced PD suboptimally controlled with L-dopa were randomized to adjunctive ropinirole prolonged release (2–24 mg/day) or placebo for 24 weeks. Awake/asleep and, if awake, “on”/“off” status was recorded via diary cards. At week 24 last observation carried forward, changes in nighttime or daytime sleep duration were not significantly different between treatments. Of patients with baseline awakenings, a significantly higher proportion in the ropinirole prolonged release group had a reduction in awakenings versus placebo. Patients receiving ropinirole prolonged release had a significantly greater increase in amount/percentage of awake time “on”/“on” without troublesome dyskinesia during all periods assessed (including night-time and early morning), versus placebo, and higher odds for being “on” on waking. Adjunctive once-daily ropinirole prolonged release may help provide 24-hour symptom control in patients with advanced PD not optimally controlled with L-dopa. PMID:21687750

  5. Silica-Based and Borate-Based, Titania-Containing Bioactive Coatings Characterization: Critical Strain Energy Release Rate, Residual Stresses, Hardness, and Thermal Expansion.

    Rodriguez, Omar; Matinmanesh, Ali; Phull, Sunjeev; Schemitsch, Emil H; Zalzal, Paul; Clarkin, Owen M; Papini, Marcello; Towler, Mark R


    Silica-based and borate-based glass series, with increasing amounts of TiO₂ incorporated, are characterized in terms of their mechanical properties relevant to their use as metallic coating materials. It is observed that borate-based glasses exhibit CTE (Coefficient of Thermal Expansion) closer to the substrate's (Ti6Al4V) CTE, translating into higher mode I critical strain energy release rates of glasses and compressive residual stresses and strains at the coating/substrate interface, outperforming the silica-based glasses counterparts. An increase in the content of TiO₂ in the glasses results in an increase in the mode I critical strain energy release rate for both the bulk glass and for the coating/substrate system, proving that the addition of TiO₂ to the glass structure enhances its toughness, while decreasing its bulk hardness. Borate-based glass BRT3, with 15 mol % TiO₂ incorporated, exhibits superior properties overall compared to the other proposed glasses in this work, as well as 45S5 Bioglass(®) and Pyrex.

  6. Heart rate and time-motion analyses in top junior players during basketball matches

    Karel Hůlka


    Full Text Available BACKGROUND: Basketball performance can be classified as an intermittent physical activity due to the changing situational game conditions and the number of intervening variables. It is necessary to have detailed knowledge about the performance of basketball players during a match as a background for more specific planning of the training process. OBJECTIVE: The aim of this study was to analyse the indicators of internal and external load of basketball player’s performance during a match of U18 top men basketball players as a background for the planning of specific training processes. METHODS: Thirty-two Czech top junior basketball players (male, aged 16.88 ± 0.72 years participated in this research. The heart rate was recorded and time-motion analysis was conducted during six warm-up matches. RESULTS: The average heart rate was measured to be 167.47 ± 13.01 beats • min.–1, which corresponded to 85.06 ± 6.40% of peak heart rate. The percentages of the total time spent over and under 85% were 63.12% and 36.88%, respectively. Average distance covered was measured to be 5,880.91 ± 831.01 meters. The average work : rest ratio was 1 : 7.95 ± 1.83, ranging from 1 : 4.80 to 1 : 10.92. CONCLUSIONS: The results from these matches suggest that the exercise intensity and sprint activity observed during junior basketball are dependent on the player's position and partly on the level of the performance. The heart rate during a match was not dependent on the positions, however, time-motion analysis revealed significant differences between three basketball positions during a match. The combination of heart rate and time-motion analysis is recommended.

  7. The mortality rates and the space-time patterns of John Snow's cholera epidemic map.

    Shiode, Narushige; Shiode, Shino; Rod-Thatcher, Elodie; Rana, Sanjay; Vinten-Johansen, Peter


    Snow's work on the Broad Street map is widely known as a pioneering example of spatial epidemiology. It lacks, however, two significant attributes required in contemporary analyses of disease incidence: population at risk and the progression of the epidemic over time. Despite this has been repeatedly suggested in the literature, no systematic investigation of these two aspects was previously carried out. Using a series of historical documents, this study constructs own data to revisit Snow's study to examine the mortality rate at each street location and the space-time pattern of the cholera outbreak. This study brings together records from a series of historical documents, and prepares own data on the estimated number of residents at each house location as well as the space-time data of the victims, and these are processed in GIS to facilitate the spatial-temporal analysis. Mortality rates and the space-time pattern in the victims' records are explored using Kernel Density Estimation and network-based Scan Statistic, a recently developed method that detects significant concentrations of records such as the date and place of victims with respect to their distance from others along the street network. The results are visualised in a map form using a GIS platform. Data on mortality rates and space-time distribution of the victims were collected from various sources and were successfully merged and digitised, thus allowing the production of new map outputs and new interpretation of the 1854 cholera outbreak in London, covering more cases than Snow's original report and also adding new insights into their space-time distribution. They confirmed that areas in the immediate vicinity of the Broad Street pump indeed suffered from excessively high mortality rates, which has been suspected for the past 160 years but remained unconfirmed. No distinctive pattern was found in the space-time distribution of victims' locations. The high mortality rates identified around the

  8. Increasing health examination survey participation rates by SMS reminders and flexible examination times.

    Tolonen, Hanna; Aistrich, Anna; Borodulin, Katja


    Declining participation rates are an increasing problem in population surveys. Different kinds of methods have been used to ensure participation rates as high as possible. Monetary incentives and reminders have been found to be effective ways to increase participation rates, but these are rather expensive to implement in large population surveys. There is a need for cheaper ways to motivate survey invitees to participate. The Kuusamo Health Examination Survey was conducted in May-June 2011. A random sample of 250 people was selected for the survey. Mobile phone numbers, when available, were obtained for people within the sample. For a random sample of 50% of survey invitees with a mobile phone number, a short message service (SMS) reminder was sent prior to their appointment. All survey participants were asked to fill in a feedback questionnaire. Participation rate was 58% for men and 74% for women. Mobile phone numbers were available for 66% of the sample. Among those receiving an SMS reminder about their appointment, participation rates were up to 25 percentage points higher than among the group not receiving a reminder. In the feedback questionnaire, 9% of the survey participants reported that they would not have participated without the SMS reminder they received. Participants preferred morning hours and Monday-Tuesday as time and day options for the examinations. SMS reminder about the appointment time was an effective way to increase participation rate, especially among the youngest age groups also, providing flexible office hours for the examination clinic may increase participation rate. © 2014 the Nordic Societies of Public Health.

  9. Designing Process Improvement of Finished Good On Time Release and Performance Indicator Tool in Milk Industry Using Business Process Reengineering Method

    Dachyar, M.; Christy, E.


    To maintain position as a major milk producer, the Indonesian milk industry should do some business development with the purpose of increasing customer service level. One strategy is to create on time release conditions for finished goods which will be distributed to customers and distributors. To achieve this condition, management information systems of finished goods on time release needs to be improved. The focus of this research is to conduct business process improvement using Business Process Reengineering (BPR). The deliverable key of this study is a comprehensive business strategy which is the solution of the root problems. To achieve the goal, evaluation, reengineering, and improvement of the ERP system are conducted. To visualize the predicted implementation, a simulation model is built by Oracle BPM. The output of this simulation showed that the proposed solution could effectively reduce the process lead time and increase the number of quality releases.

  10. An SIR Epidemic Model with Time Delay and General Nonlinear Incidence Rate

    Mingming Li


    Full Text Available An SIR epidemic model with nonlinear incidence rate and time delay is investigated. The disease transmission function and the rate that infected individuals recovered from the infected compartment are assumed to be governed by general functions F(S,I and G(I, respectively. By constructing Lyapunov functionals and using the Lyapunov-LaSalle invariance principle, the global asymptotic stability of the disease-free equilibrium and the endemic equilibrium is obtained. It is shown that the global properties of the system depend on both the properties of these general functions and the basic reproductive number R0.

  11. On the time-homogeneous Ornstein–Uhlenbeck process in the foreign exchange rates

    Fonseca, Regina C.B. da, E-mail: [Department of Mathematics, Instituto Federal de Goiás, Goiânia, Goiás 74055-110 (Brazil); International Center for Condensed Matter Physics, Instituto de Física, Universidade de Brasília, Caixa Postal 04455, 70919-970, Brasília, Distrito Federal (Brazil); Matsushita, Raul Y. [Department of Statistics, Universidade de Brasília, 70919-970, Brasília, Distrito Federal (Brazil); Castro, Márcio T. de; Figueiredo, Annibal [International Center for Condensed Matter Physics, Instituto de Física, Universidade de Brasília, Caixa Postal 04455, 70919-970, Brasília, Distrito Federal (Brazil)


    Since Gaussianity and stationarity assumptions cannot be fulfilled by financial data, the time-homogeneous Ornstein–Uhlenbeck (THOU) process was introduced as a candidate model to describe time series of financial returns [1]. It is an Ornstein–Uhlenbeck (OU) process in which these assumptions are replaced by linearity and time-homogeneity. We employ the OU and THOU processes to analyze daily foreign exchange rates against the US dollar. We confirm that the OU process does not fit the data, while in most cases the first four cumulants patterns from data can be described by the THOU process. However, there are some exceptions in which the data do not follow linearity or time-homogeneity assumptions. - Highlights: • Gaussianity and stationarity assumptions replaced by linearity and time-homogeneity. • We revisit the time-homogeneous Ornstein–Uhlenbeck (THOU) process. • We employ the THOU process to analyze foreign exchange rates against the US dollar. • The first four cumulants patterns from data can be described by the THOU process.

  12. Investigation of Bicycle Travel Time Estimation Using Bluetooth Sensors for Low Sampling Rates

    Zhenyu Mei


    Full Text Available Filtering the data for bicycle travel time using Bluetooth sensors is crucial to the estimation of link travel times on a corridor. The current paper describes an adaptive filtering algorithm for estimating bicycle travel times using Bluetooth data, with consideration of low sampling rates. The data for bicycle travel time using Bluetooth sensors has two characteristics. First, the bicycle flow contains stable and unstable conditions. Second, the collected data have low sampling rates (less than 1%. To avoid erroneous inference, filters are introduced to “purify” multiple time series. The valid data are identified within a dynamically varying validity window with the use of a robust data-filtering procedure. The size of the validity window varies based on the number of preceding sampling intervals without a Bluetooth record. Applications of the proposed algorithm to the dataset from Genshan East Road and Moganshan Road in Hangzhou demonstrate its ability to track typical variations in bicycle travel time efficiently, while suppressing high frequency noise signals.

  13. Tectonic, lithologic and climatic controls on knickpoint retreat rates and landscape response times

    Whittaker, Alexander; Boulton, Sarah; Kent, Emiko; Alçiçek, Cihat


    The plan-view and vertical rates at which transient knickpoints propagate through a landscape fundamentally controls geomorphic response times to tectonic and climatic perturbations. Here we present knickpoint retreat rates upstream of active faults for bedrock catchments in the Gediz graben of Turkey where past climate is well documented but where the history of faulting is not fully constrained. The rivers upstream of the normal fault-bounded graben each contain a non-lithologic knickpoint, including those that drain through inferred fault segment boundaries. Knickpoint heights measured vertically from the fault scale with footwall relief and documented fault throw (vertical displacement). Consequently, we deduce these knickpoints were initiated by an increase in slip rate on the basin-bounding fault, driven by linkage of the three main fault segments of the high-angle graben-bounding fault array. Fault interaction theory and ratios of channel steepness suggest that the slip rate enhancement factor on linkage was a factor of 3. We combine this information with geomorphic and structural constraints to estimate that linkage took place between 0.6 Ma and 1 Ma. Calculated pre- and post- linkage throw rates are 0.6 and 2 mm/yr respectively. Maximum plan-view knickpoint retreat rates upstream of the faults range from 4.5 to 28 mm/yr, and when normalised by drainage area, they are 2-7 times faster than for similar catchments upstream of normal faults in the Central Apennines of Italy and the Hatay Graben of Turkey. These knickpoint retreat rates imply a fluvial response time to fault growth and interaction of 1.6 to 2.7 My. However, marked along-strike disparities in retreat rates exist. We demonstrate that climate differences may explain the variation in rates between these study areas, but not within the Gediz graben itself. Consequently, we evaluate the extent to which measureable differences in bedrock lithology and erodibility modulate the propagation of

  14. Real time heart rate variability assessment from Android smartphone camera photoplethysmography: Postural and device influences.

    Guede-Fernandez, F; Ferrer-Mileo, V; Ramos-Castro, J; Fernandez-Chimeno, M; Garcia-Gonzalez, M A


    The aim of this paper is to present a smartphone based system for real-time pulse-to-pulse (PP) interval time series acquisition by frame-to-frame camera image processing. The developed smartphone application acquires image frames from built-in rear-camera at the maximum available rate (30 Hz) and the smartphone GPU has been used by Renderscript API for high performance frame-by-frame image acquisition and computing in order to obtain PPG signal and PP interval time series. The relative error of mean heart rate is negligible. In addition, measurement posture and the employed smartphone model influences on the beat-to-beat error measurement of heart rate and HRV indices have been analyzed. Then, the standard deviation of the beat-to-beat error (SDE) was 7.81 ± 3.81 ms in the worst case. Furthermore, in supine measurement posture, significant device influence on the SDE has been found and the SDE is lower with Samsung S5 than Motorola X. This study can be applied to analyze the reliability of different smartphone models for HRV assessment from real-time Android camera frames processing.

  15. Rate-limited electroless gold thin film growth: a real-time study.

    Jang, Gyoung Gug; Blake, Phillip; Roper, D Keith


    Time-resolved, in situ spectroscopy of electroless (EL) gold (Au) films combined with electron microscopy showed that the deposition rate increased up to two-fold on surfaces swept by the bulk flow of adjacent fluid at Reynolds numbers less than 1.0, compared to batch immersion. Deposition rates from 5.0 to 9.0 nm/min and thicknesses of the EL Au film from 20 to 100 nm, respectively, increased predictably with flow rate at conditions when the deposition was limited primarily by Fickian diffusion. Time-frames were identified for metal island nucleation, growth, and subsequent film development during EL Au deposition by real-time UV-visible spectroscopy of photoluminescence (PL) and surface plasmon features of nanoscale metal deposits. Film thicknesses measured by scanning electron microscopy and X-ray photoelectron spectroscopy paired with real-time optical spectroscopy of kinetic aspects of plasmon and PL optical features indicated that Au film deposition on surfaces swept by a steady flow of adjacent fluid can be primarily diffusion limited.

  16. A Harmony Search Algorithm with Multi-pitch Adjustment Rate for Symbolic Time Series Data Representation

    Almahdi M. Ahmed


    Full Text Available The representation task in time series data mining has been a critical issue because the direct manipulation of continuous, high-dimensional data is extremely difficult to complete efficiently. One time series representation approach is a symbolic representation called the Symbolic Aggregate Approximation (SAX. The main function of SAX is to find the appropriate numbers of alphabet symbols and word size that represent the time series. The aim is to achieve the largest alphabet size and maximum word length with the minimum error rate. The purpose of this study is to propose an integrated approach for a symbolic time series data representation that attempts to improve SAX by improving alphabet and word size. The Relative Frequency (RF binning method is employed to obtain alphabet size and is integrated with the proposed Multi-pitch Harmony Search (HSMPAR algorithm to calculate the optimum alphabet and word size. RF is used because of its ability to obtain a sufficient number of intervals with a low error rate compared to other related techniques. HSMPAR algorithm is an optimization algorithm that randomly generates solutions for alphabet and word sizes and selects the best solutions. HS algorithms are compatible with multi-pitch adjustment. The integration of the RF and HSMPAR algorithms is developed to maximize information rather than to improve the error rate. The algorithms are tested on 20 standard time series datasets and are compared with the meta-heuristic algorithms GENEBLA and the original SAX algorithm. The experimental results show that the proposed method generates larger alphabet and word sizes and achieves a lower error rate than the compared methods. With larger alphabet and word sizes, the proposed method is capable of preserving important information.

  17. Effect of gonadotropin secretion rate on the radiosensitivity of the rat luteinizing hormone-releasing hormone neuron and gonadotroph

    Winterer, J.; Barnes, K.M.; Lichter, A.S.; Deluca, A.M.; Loriaux, D.L.; Cutler, G.B. Jr.


    To test the hypothesis that the functional state of hypothalamic LHRH neurons and pituitary gonadotrophs might alter their radiosensitivity, we determined the experimental conditions under which the gonadotropin response to castration could be impaired by a single dose of cranial irradiation. Single doses of cranial irradiation greater than 2000 rads were lethal to unshielded rats. Shielding of the oropharynx and esophagus allowed the animals to survive doses up to 5000 rads. Doses between 2000 and 5000 rads had no effect on basal gonadotropin levels for as long as 3 months after irradiation. Irradiation caused a dose- and time-dependent impairment, however, in the gonadotropin response to castration. Impairment of the gonadotropin levels of castrate animals occurred in animals that were irradiated either before or after castration. However, rats irradiated in the castrate state showed a decreased susceptibility to irradiation damage. Additionally, stimulation of the pituitary by LHRH agonist (LHRHa) 3 h before irradiation significantly reduced the impairment of gonadotropin secretion 12-20 weeks after irradiation (P less than 0.05). Thus, increased functional activity of the rat hypothalamus or pituitary at the time of irradiation, induced by either castration or acute LHRHa administration, was associated with some protection against the gonadotropin-lowering effect of irradiation. Based upon these data, we hypothesize that stimulation of gonadotropin secretion at the time of therapeutic cranial irradiation in humans might protect against subsequent impairment of gonadotropin secretion.

  18. Exploitation of 3D face-centered cubic mesoporous silica as a carrier for a poorly water soluble drug: Influence of pore size on release rate

    Zhu, Wenquan; Wan, Long; Zhang, Chen; Gao, Yikun; Zheng, Xin; Jiang, Tongying; Wang, Siling, E-mail:


    The purposes of the present work were to explore the potential application of 3D face-centered cubic mesoporous silica (FMS) with pore size of 16.0 nm as a delivery system for poorly soluble drugs and investigate the effect of pore size on the dissolution rate. FMS with different pore sizes (16.0, 6.9 and 3.7 nm) was successfully synthesized by using Pluronic block co-polymer F127 as a template and adjusting the reaction temperatures. Celecoxib (CEL), which is a BCS class II drug, was used as a model drug and loaded into FMS with different pore sizes by the solvent deposition method at a drug–silica ratio of 1:4. Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transformation infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), nitrogen adsorption, X-ray diffraction (XRD), and differential scanning calorimetry (DSC) was used to systematically investigate the drug loading process. The results obtained showed that CEL was in a non-crystalline state after incorporation of CEL into the pores of FMS-15 with pore size of 16.0 nm. In vitro dissolution was carried out to demonstrate the effects of FMS with different pore sizes on the release of CEL. The results obtained indicated that the dissolution rate of CEL from FMS-15 was significantly enhanced compared with pure CEL. This could be explained by supposing that CEL encountered less diffusion resistance and its crystallinity decreased due to the large pore size of 16.0 nm and the nanopore channels of FMS-15. Moreover, drug loading and pore size both play an important role in enhancing the dissolution properties for the poorly water-soluble drugs. As the pore size between 3.7 and 16.0 nm increased, the dissolution rate of CEL from FMS gradually increased. - Highlights: • Exploitation of 3D cubic mesoporous silica (16 nm) as a carrier was completed. • The release rate of CEL increased on increasing the pore size of carriers. • The crystallinity

  19. Elevated time-dependent strengthening rates observed in San Andreas Fault drilling samples

    Ikari, Matt J.; Carpenter, Brett M.; Vogt, Christoph; Kopf, Achim J.


    The central San Andreas Fault in California is known as a creeping fault, however recent studies have shown that it may be accumulating a slip deficit and thus its seismogenic potential should be seriously considered. We conducted laboratory friction experiments measuring time-dependent frictional strengthening (healing) on fault zone and wall rock samples recovered during drilling at the San Andreas Fault Observatory at Depth (SAFOD), located near the southern edge of the creeping section and in the direct vicinity of three repeating microearthquake clusters. We find that for hold times of up to 3000 s, frictional healing follows a log-linear dependence on hold time and that the healing rate is very low for a sample of the actively shearing fault core, consistent with previous results. However, considering longer hold times up to ∼350,000 s, the healing rate accelerates such that the data for all samples are better described by a power law relation. In general, samples having a higher content of phyllosilicate minerals exhibit low log-linear healing rates, and the notably clay-rich fault zone sample also exhibits strong power-law healing when longer hold times are included. Our data suggest that weak faults, such as the creeping section of the San Andreas Fault, can accumulate interseismic shear stress more rapidly than expected from previous friction data. Using the power-law dependence of frictional healing on hold time, calculations of recurrence interval and stress drop based on our data accurately match observations of discrete creep events and repeating Mw = 2 earthquakes on the San Andreas Fault.

  20. The impact of different sampling rates and calculation time intervals on ROTI values

    Jacobsen Knut Stanley


    Full Text Available The ROTI (Rate of TEC index is a commonly used measure of ionospheric irregularities level. The algorithm to calculate ROTI is easily implemented, and is the same from paper to paper. However, the sample rate of the GNSS data used, and the time interval over which a value of ROTI is calculated, varies from paper to paper. When comparing ROTI values from different studies, this must be taken into account. This paper aims to show what these differences are, to increase the awareness of this issue. We have investigated the effect of different parameters for the calculation of ROTI values, using one year of data from 8 receivers at latitudes ranging from 59° N to 79° N. We have found that the ROTI values calculated using different parameter choices are strongly positively correlated. However, the ROTI values are quite different. The effect of a lower sample rate is to lower the ROTI value, due to the loss of high-frequency parts of the ROT spectrum, while the effect of a longer calculation time interval is to remove or reduce short-lived peaks due to the inherent smoothing effect. The ratio of ROTI values based on data of different sampling rate is examined in relation to the ROT power spectrum. Of relevance to statistical studies, we find that the median level of ROTI depends strongly on sample rate, strongly on latitude at auroral latitudes, and weakly on time interval. Thus, a baseline “quiet” or “noisy” level for one location or choice or parameters may not be valid for another location or choice of parameters.

  1. Rates of processes with coherent production of different particles and the GSI time anomaly

    Giunti, Carlo [INFN, Sezione di Torino, Via P. Giuria 1, I-10125 Torino (Italy)], E-mail:


    With the help of an analogy with a double-slit experiment, it is shown that the standard method of calculation of the rate of an interaction process by adding the rates of production of all the allowed channels, regardless of a possible coherence among them, is correct. The claims that the GSI time anomaly is due to the mixing of neutrinos in the final state of the electron-capture process are refuted. It is shown that the GSI time anomaly may be due to quantum beats due to the existence of two coherent energy levels of the decaying ion with an extremely small energy splitting (about 10{sup -15} eV) and relative probabilities having a ratio of about 1/0008.

  2. A time-varying parameter VAR investigation of the exchange rate pass-through in Turkey

    Çatık Abdurrahman Nazif


    Full Text Available The effects of exchange rate movements on price levels have important implications to macroeconomic policies through the impacts on trade balance and inflation. In contrast to previous studies, we employ a VAR model with time-varying parameters to measure the magnitude of exchange rate pass-through (ERPT. The findings confirm the time-varying pattern in the ERPT, as the magnitude of ERPT has reached its maximum value during the 1994 financial crisis. The decline in the magnitude of ERPT has become more pronounced after the 2001 financial crisis as a result of the implementation of inflation targeting, which has shifted Turkey’s economy from a long lasting high inflationary phase to a low inflationary economic environment.

  3. Phosphoproteomics analysis of postmortem porcine muscle with pH decline rate and time difference

    Huang, Honggang; Larsen, Martin R; Karlsson, Anders H


    The aim of this study was to characterize the protein phosphorylation in postmortem (PM) muscle and reveal the change during meat quality development. The gel-based phosphoproteomic analysis of PM porcine muscle was performed in three pig groups with different pH decline rates from PM 1h to 24 h...... the reverse case. The phosphorylation level of 12 bands in sarcoplasmic fraction and 3 bands in myofibrillar fraction were significantly affected by the synergy effects of pH and time (pproteins were identified. The phosphorylation patterns of pyruvate kinase, triosephosphate isomerase-1......, tropomyosin and myosin regulatory light chain 2 showed to be related to PM muscle pH decline rate and time. Our work sheds light on the potential role of protein phosphorylation on regulation of meat quality development....

  4. Shortening gametes co-incubation time improves live birth rate for couples with a history of fragmented embryos.

    Le Bras, Anne; Hesters, Laetitia; Gallot, Vanessa; Tallet, Cathie; Tachdjian, Gerard; Frydman, Nelly


    Short gamete co-incubation (SGCO) consists in decreasing the duration of contact between oocytes and sperm from the standard overnight insemination (SOI) toward 2 hours. However, the effectiveness of this technique to improve in vitro fertilization and embryo transfer (IVF-ET) outcomes remains controversial. Our study was designed to evaluate the efficiency of SGCO in a poor prognosis population with a history of fragmented embryos defined by the presence of at least 50% of the embryos with more than 25% of cytoplasmic fragments. From January 2010 to January 2014, 97 couples were included in a SGCO protocol. We separated women into 2 subgroups: younger and older than 35 years. Compared to SOI, after SGCO, 2-cell stage embryos were higher in all women (p<0.001) and less fragmented in women over 35 years (p<0.05). On day 2, top quality embryos obtained and transferred were higher with SCGO than with SOI, independently of the age of the women (p<0.001). Moreover, the number of embryos with less than 25% of fragmentation was higher after SGCO than SOI (p<0.001) whereas the number of multinucleated embryos was lower (p<0.001). We observed that after fresh ET, independently of the age of the women, the clinical pregnancy rate was 3 times higher after SGCO than after SOI. However, the live-birth rate was 4 times higher with SGCO than with SOI in women above 35 years but 3 times higher with SGCO than with SOI in women younger than 35 years. The present results indicate that for a particular indication, reducing the time of oocytes and sperm co-incubation may improve IVF-ET outcomes in terms of live-birth rate. AMH: anti mullerian hormone; COC: cumulus-oocytes complex; E2: estradiol; ET: embryo transfer; FET: frozen embryo transfer; FSH: follicle stimulating hormone; GnRH: gonadotrophin releasing hormone; hCG: human chorionic gonadotropin hormone; hMG: human menopausal gonadotropin hormone; IRB: institutional review board; IVF: in vitro fertilization; IVF-ET: in vitro

  5. Diving reflex: can the time course of heart rate reduction be quantified?

    Caspers, C; Cleveland, S; Schipke, J D


    In this meta-analysis of diving bradycardia in humans, we sought to quantify any heart rate (HR) reduction using a relatively simple mathematical function. Using the terms "diving reflex,"diving bradycardia,"diving response,"diving plus heart rate," databases were searched. Data from the studies were fitted using HR=c+aexp(-(t-t(0))/τ), where c is the final HR, a is the HR decrease, τ is the time constant of HR decay, and t(0) is the time delay. Of 890 studies, 220 were given closer scrutiny. Only eight of these provided data obtained under comparable conditions. Apneic facial immersion decreased HR with τ=10.4 s and in air alone it was less pronounced and slower (τ=16.2 s). The exponential function fitted the time course of HR decrease closely (r(2)>0.93). The fit was less adequate for apneic-exercising volunteers. During apnea both with and without face immersion, HR decreases along a monoexponential function with a characteristic time constant. HR decrease during exercise with and without face immersion could not readily be described with a simple function: the parasympathetic reaction was partially offset by some sympathetic activity. Thus, we succeeded in quantifying the early time course of diving bradycardia. It is concluded that the diving reflex is useful to diagnose the integrity of efferent cardiovascular autonomic pathways. © 2010 John Wiley & Sons A/S.

  6. Left ventricular ejection time, not heart rate, is an independent correlate of aortic pulse wave velocity.

    Salvi, Paolo; Palombo, Carlo; Salvi, Giovanni Matteo; Labat, Carlos; Parati, Gianfranco; Benetos, Athanase


    Several studies showed a positive association between heart rate and pulse wave velocity, a sensitive marker of arterial stiffness. However, no study involving a large population has specifically addressed the dependence of pulse wave velocity on different components of the cardiac cycle. The aim of this study was to explore in subjects of different age the link between pulse wave velocity with heart period (the reciprocal of heart rate) and the temporal components of the cardiac cycle such as left ventricular ejection time and diastolic time. Carotid-femoral pulse wave velocity was assessed in 3,020 untreated subjects (1,107 men). Heart period, left ventricular ejection time, diastolic time, and early-systolic dP/dt were determined by carotid pulse wave analysis with high-fidelity applanation tonometry. An inverse association was found between pulse wave velocity and left ventricular ejection time at all ages (pulse wave velocity and heart period was also found, with the exception of the youngest subjects (P = 0.20). A significant positive correlation was also found between pulse wave velocity and dP/dt (P pulse wave velocity at all ages, whereas the contribution of heart period no longer became significant. Our data demonstrate that pulse wave velocity is more closely related to left ventricular systolic function than to heart period. This may have methodological and pathophysiological implications.

  7. Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets.

    Jacoba M Maurer

    Full Text Available ColoPulse tablets are an innovative development in the field of oral dosage forms characterized by a distal ileum and colon-specific release. Previous studies in humans showed release in the ileo-colonic region, but the relationship between gastrointestinal pH and release was not experimentally proven in vivo. This information will complete the in vivo release-profile of ColoPulse tablets.Release from ColoPulse tablets was studied in 16 healthy volunteers using the dual label isotope strategy. To determine gastrointestinal pH profiles and transit times the IntelliCap system was used. A ColoPulse tablet containing 13C-urea and an uncoated, immediate release tablet containing 15N2-urea were taken simultaneously followed by a standardized breakfast after three hours. Five minutes after intake of the tablets the IntelliCap capsule was swallowed and pH was measured until excretion in the feces. Breath and urine samples were collected for isotope analysis.Full analysis could be performed in 12 subjects. Median bioavailability of 13C -urea was 82% (95% CI 74-94%, range 61-114%. The median lag time (5% release of 13C was 5:42 h (95% CI 5:18-6:18 h, range 2:36-6:36 h, There was no statistically significant difference between lag time based on isotope signal and colon arrival time (CAT based on pH (median 5:42 vs 5:31 h p = 0.903. In all subjects an intestinal pH value of 7.0 was reached before release of 13C from the ColoPulse tablet occurred.From the combined data from the IntelliCap system and the 13C -isotope signal it can be concluded that release from a ColoPulse tablet in vivo is not related to transit times but occurs in the ileo-colonic region after pH 7.0 is reached. This supports our earlier findings and confirms that the ColoPulse system is a promising delivery system for targeting the distal ileum and colon.ISRCTN Registry 18301880.

  8. Information-transmission rates in manual control of unstable systems with time delays.

    Lupu, Mircea F; Sun, Mingui; Wang, Fei-Yue; Mao, Zhi-Hong


    In analyzing the human-machine interaction (HMI), a human-centered approach is needed to address the potential and limitation of human control, especially in the control of high-order or unstable systems. However, there is no quantitative measure of the human performance or cognitive workload in these difficult HMI tasks. We propose to characterize the HMI as information flows quantified by the information-transmission rate in bits per second (b/s). Using information- and control-theoretic approaches, we derive the minimum rates of information transmission in manual control required by any deterministic controller to stabilize the feedback system. Furthermore, we suggest a method adopted from time-series analysis to estimate the information-transmission rate from human experiments. We show that the relationship between the empirically estimated information rates and the minimum bounds allows for the quantitative indication of the potential and limitation of human manual control. We illustrate our method in the control of an inverted pendulum with time delays.

  9. Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses.

    Sudhakar, Shyam Kumar; Torben-Nielsen, Benjamin; De Schutter, Erik


    Neurons of the cerebellar nuclei convey the final output of the cerebellum to their targets in various parts of the brain. Within the cerebellum their direct upstream connections originate from inhibitory Purkinje neurons. Purkinje neurons have a complex firing pattern of regular spikes interrupted by intermittent pauses of variable length. How can the cerebellar nucleus process this complex input pattern? In this modeling study, we investigate different forms of Purkinje neuron simple spike pause synchrony and its influence on candidate coding strategies in the cerebellar nuclei. That is, we investigate how different alignments of synchronous pauses in synthetic Purkinje neuron spike trains affect either time-locking or rate-changes in the downstream nuclei. We find that Purkinje neuron synchrony is mainly represented by changes in the firing rate of cerebellar nuclei neurons. Pause beginning synchronization produced a unique effect on nuclei neuron firing, while the effect of pause ending and pause overlapping synchronization could not be distinguished from each other. Pause beginning synchronization produced better time-locking of nuclear neurons for short length pauses. We also characterize the effect of pause length and spike jitter on the nuclear neuron firing. Additionally, we find that the rate of rebound responses in nuclear neurons after a synchronous pause is controlled by the firing rate of Purkinje neurons preceding it.

  10. Heart rate, blood lactate concentration, and time-motion analysis of female basketball players during competition.

    Matthew, Dionne; Delextrat, Anne


    The aim of this study was to examine the physiological demands and movement patterns of female basketball players after changes in the rules of the game. Nine varsity players were studied during nine official games. Each game was videotaped to identify the frequencies of the main movements performed, heart rate was recorded continuously, and blood samples were collected to determine blood lactate concentration when the competition rules allowed. The main results showed that the players performed on average 652 +/- 128 movements per game, which corresponded to a change in activity every 2.82 s. Mean heart rate was 165 +/- 9 beats . min(-1) (89.1% of maximum heart rate) for total time and 170 +/- 8 beats . min(-1) (92.5% of maximum) for live time. Mean blood lactate concentration was 5.2 +/- 2.7 mmol . l(-1) (55.9% of maximum blood lactate concentration). In addition, heart rates were significantly higher in the first half than the second half of games. These results indicate: (1) a greater physiological load compared with previous studies on female players tested before the rules modification (Beam & Merrill, 1994; McArdle et al., 1971) and (2) lower movement frequencies compared with male players competing under modern rules (Ben Abdelkrim et al., 2007). These observations must be taken into account by coaches and conditioning specialists working with female players.

  11. Time Decay Rates of the Isotropic Non-Newtonian Flows in Rn

    Bo-Qing Dong


    This paper is concerned with time decay rates for weak solutions to a class system of isotropic incompressible non-Newtonian fluid motion in Rn. With the use of the spectral decomposition methods of Stokes operator, the optimal decay estimates of weak solutions in L2 norm are derived under the different conditions on the initial velocity. Moreover, the error estimates of the difference between non-Newtonian flow and Navier-Stokes flow are also investigated.

  12. Dynamic output feedback for discrete-time systems under amplitude and rate actuator constraints

    Silva Junior, Joao Manoel Gomes da; Limon Marruedo, Daniel; Alamo Cantarero, Teodoro Rafael; Camacho, Eduardo F.


    This work proposes a technique for the design of stabilizing dynamic output feedback controllers for discrete-time linear systems with rate and amplitude saturating actuators. The nonlinear effects introduced by the saturations in the closed-loop system are taken into account by using a generalized sector condition, which leads to theoretical conditions for solving the problem directly in the form of linear matrix inequalities.

  13. Comparing Response Times and Error Rates in a Simultaneous Masking Paradigm

    F Hermens


    Full Text Available In simultaneous masking, performance on a foveally presented target is impaired by one or more flanking elements. Previous studies have demonstrated strong effects of the grouping of the target and the flankers on the strength of masking (e.g., Malania, Herzog & Westheimer, 2007. These studies have predominantly examined performance by measuring offset discrimination thresholds as a measure of performance, and it is therefore unclear whether other measures of performance provide similar outcomes. A recent study, which examined the role of grouping on error rates and response times in a speeded vernier offset discrimination task, similar to that used by Malania et al. (2007, suggested a possible dissociation between the two measures, with error rates mimicking threshold performance, but response times showing differential results (Panis & Hermens, 2014. We here report the outcomes of three experiments examining this possible dissociation, and demonstrate an overall similar pattern of results for error rates and response times across a broad range of mask layouts. Moreover, the pattern of results in our experiments strongly correlates with threshold performance reported earlier (Malania et al., 2007. Our results suggest that outcomes in a simultaneous masking paradigm do not critically depend on the outcome measure used, and therefore provide evidence for a common underlying mechanism.

  14. Real-Time Analysis of Electrocardiographic Data for Heart Rate Turbulence

    Greco, E. Carl, Jr.


    Episodes of ventricular ectopy (premature ventricular contractions, PVCs) have been reported in several astronauts and cosmonauts during space flight. Indeed, the "Occurrence of Serious Cardiac Dysrhythmias" is now NASA's #1 priority critical path risk factor in the cardiovascular area that could jeopardize a mission as well as the health and welfare of the astronaut. Epidemiological, experimental and clinical observations suggest that severe autonomic dysfunction and/or transient cardiac ischemia can initiate potentially lethal ventricular arrhythmias. On earth, Heart Rate Turbulence (HRT) in response to PVCs has been shown to provide not only an index of baroreflex sensitivity (BRS), but also more importantly, an index of the propensity for lethal ventricular arrhythmia. An HRT procedure integrated into the existing advanced electrocardiographic system under development in JSC's Human Adaptation and Countermeasures Office was developed to provide a system for assessment of PVCs in a real-time monitoring or offline (play-back) scenario. The offline heart rate turbulence software program that was designed in the summer of 2003 was refined and modified for "close to" real-time results. In addition, assistance was provided with the continued development of the real-time heart rate variability software program. These programs should prove useful in evaluating the risk for arrhythmias in astronauts who do and who do not have premature ventricular contractions, respectively. The software developed for these projects has not been included in this report. Please contact Dr. Todd Schlegel for information on acquiring a specific program.

  15. A poly(glycerol sebacate)-coated mesoporous bioactive glass scaffold with adjustable mechanical strength, degradation rate, controlled-release and cell behavior for bone tissue engineering.

    Lin, Dan; Yang, Kai; Tang, Wei; Liu, Yutong; Yuan, Yuan; Liu, Changsheng


    Various requirements in the field of tissue engineering have motivated the development of three-dimensional scaffold with adjustable physicochemical properties and biological functions. A series of multiparameter-adjustable mesoporous bioactive glass (MBG) scaffolds with uncrosslinked poly(glycerol sebacate) (PGS) coating was prepared in this article. MBG scaffold was prepared by a modified F127/PU co-templating process and then PGS was coated by a simple adsorption and lyophilization process. Through controlling macropore parameters and PGS coating amount, the mechanical strength, degradation rate, controlled-release and cell behavior of the composite scaffold could be modulated in a wide range. PGS coating successfully endowed MBG scaffold with improved toughness and adjustable mechanical strength covering the bearing range of trabecular bone (2-12MPa). Multilevel degradation rate of the scaffold and controlled-release rate of protein from mesopore could be achieved, with little impact on the protein activity owing to an "ultralow-solvent" coating and "nano-cavity entrapment" immobilization method. In vitro studies indicated that PGS coating promoted cell attachment and proliferation in a dose-dependent manner, without affecting the osteogenic induction capacity of MBG substrate. These results first provide strong evidence that uncrosslinked PGS might also yield extraordinary achievements in traditional MBG scaffold. With the multiparameter adjustability, the composite MBG/PGS scaffolds would have a hopeful prospect in bone tissue engineering. The design considerations and coating method of this study can also be extended to other ceramic-based artificial scaffolds and are expected to provide new thoughts on development of future tissue engineering materials.

  16. Low-sampling-rate ultra-wideband channel estimation using equivalent-time sampling

    Ballal, Tarig


    In this paper, a low-sampling-rate scheme for ultra-wideband channel estimation is proposed. The scheme exploits multiple observations generated by transmitting multiple pulses. In the proposed scheme, P pulses are transmitted to produce channel impulse response estimates at a desired sampling rate, while the ADC samples at a rate that is P times slower. To avoid loss of fidelity, the number of sampling periods (based on the desired rate) in the inter-pulse interval is restricted to be co-prime with P. This condition is affected when clock drift is present and the transmitted pulse locations change. To handle this case, and to achieve an overall good channel estimation performance, without using prior information, we derive an improved estimator based on the bounded data uncertainty (BDU) model. It is shown that this estimator is related to the Bayesian linear minimum mean squared error (LMMSE) estimator. Channel estimation performance of the proposed sub-sampling scheme combined with the new estimator is assessed in simulation. The results show that high reduction in sampling rate can be achieved. The proposed estimator outperforms the least squares estimator in almost all cases, while in the high SNR regime it also outperforms the LMMSE estimator. In addition to channel estimation, a synchronization method is also proposed that utilizes the same pulse sequence used for channel estimation. © 2014 IEEE.

  17. A note on inventory model for ameliorating items with time dependent second order demand rate

    Gobinda Chandra Panda


    Full Text Available Background: This paper is concerned with the development of ameliorating inventory models. The ameliorating inventory is the inventory of goods whose utility increases over the time by ameliorating activation. Material and Methods: This study is performed according to two areas: one is an economic order quantity (EOQ model for the items whose utility is ameliorating in accordance with Weibull distribution, and the other is a partial selling quantity (PSQ model developed for selling the surplus inventory accumulated by ameliorating activation with linear demand. The aim of this paper was to develop a mathematical model for inventory type concerned in the paper. Numerical examples were presented show the effect of ameliorating rate on inventory polices.  Results and Conclusions:  The inventory model for items with Weibull ameliorating is developed. For the case of small ameliorating rate (less than linear demand rate, EOQ model is developed, and for the case where ameliorating rate is greater than linear demand rate, PSQ model is developed.  .  

  18. Simulation of the Universal-Time Diurnal Variation of the Global Electric Circuit Charging Rate

    Mackerras, D.; Darvenzia, M.; Orville, R. E.; Williams, E. R.; Goodman, S. J.


    A global lightning model that includes diurnal and annual lightning variation, and total flash density versus latitude for each major land and ocean, has been used as the basis for simulating the global electric circuit charging rate. A particular objective has been to reconcile the difference in amplitude ratios [AR=(max-min)/mean] between global lightning diurnal variation (AR approx. = 0.8) and the diurnal variation of typical atmospheric potential gradient curves (AR approx. = 0.35). A constraint on the simulation is that the annual mean charging current should be about 1000 A. The global lightning model shows that negative ground flashes can contribute, at most, about 10-15% of the required current. For the purpose of the charging rate simulation, it was assumed that each ground flash contributes 5 C to the charging process. It was necessary to assume that all electrified clouds contribute to charging by means other than lightning, that the total flash rate can serve as an indirect indicator of the rate of charge transfer, and that oceanic electrified clouds contribute to charging even though they are relatively inefficient in producing lightning. It was also found necessary to add a diurnally invariant charging current component. By trial and error it was found that charging rate diurnal variation curves in Universal time (UT) could be produced with amplitude ratios and general shapes similar to those of the potential gradient diurnal variation curves measured over ocean and arctic regions during voyages of the Carnegie Institute research vessels.

  19. Fluoride release from newly marketed fluoride varnishes.

    Jablonowski, Beth L; Bartoloni, Joseph A; Hensley, Donna M; Vandewalle, Kraig S


    New fluoride varnishes have been marketed that reportedly release more fluoride (Enamel Pro) or release fluoride more slowly (Vanish XT). The purpose of this study was to compare the amount and rate of fluoride release of new fluoride varnishes with other traditional fluoride varnishes. Extracted molars were cut into block sections. The enamel surfaces of the sections were painted with Enamel Pro, Duraphat, Vanish, or Vanish XT fluoride varnishes. One group was not treated and served as a negative control. The tooth sections were immersed in artificial saliva. The concentration of fluoride in parts per million was measured after the first 30 minutes, daily for the first week, and weekly until the level was below the limit of detection. Fluoride release was plotted over time. Cumulative fluoride release and rate of release (slope) were analyzed using one-way ANOVA/Tukey (α = .05). Enamel Pro had the greatest cumulative fluoride release. There was no significant difference between Duraphat and Vanish. Vanish XT had the lowest cumulative fluoride release. The rate of fluoride release from 1 week to limit of detection was Enamel Pro > Vanish > Duraphat > Vanish XT. The two newly marketed fluoride varnishes (Enamel Pro and Vanish XT) had significantly different fluoride release from the two conventional fluoride varnishes (Duraphat and Vanish).

  20. The rates and time-delay distribution of multiply imaged supernovae behind lensing clusters

    Li, Xue; Hjorth, Jens [Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, 2100, Copenhagen (Denmark); Richard, Johan, E-mail:, E-mail:, E-mail: [CRAL, Observatoire de Lyon, Université Lyon 1, 9 Avenue Ch. André, 69561 Saint Genis Laval Cedex (France)


    Time delays of gravitationally lensed sources can be used to constrain the mass model of a deflector and determine cosmological parameters. We here present an analysis of the time-delay distribution of multiply imaged sources behind 17 strong lensing galaxy clusters with well-calibrated mass models. We find that for time delays less than 1000 days, at z = 3.0, their logarithmic probability distribution functions are well represented by P(log Δt) = 5.3 × 10{sup −4}Δt{sup β-tilde}/M{sub 250}{sup 2β-tilde}, with β-tilde = 0.77, where M{sub 250} is the projected cluster mass inside 250 kpc (in 10{sup 14}M{sub ☉}), and β-tilde is the power-law slope of the distribution. The resultant probability distribution function enables us to estimate the time-delay distribution in a lensing cluster of known mass. For a cluster with M{sub 250} = 2 × 10{sup 14}M{sub ☉}, the fraction of time delays less than 1000 days is approximately 3%. Taking Abell 1689 as an example, its dark halo and brightest galaxies, with central velocity dispersions σ≥500kms{sup −1}, mainly produce large time delays, while galaxy-scale mass clumps are responsible for generating smaller time delays. We estimate the probability of observing multiple images of a supernova in the known images of Abell 1689. A two-component model of estimating the supernova rate is applied in this work. For a magnitude threshold of m{sub AB} = 26.5, the yearly rate of Type Ia (core-collapse) supernovae with time delays less than 1000 days is 0.004±0.002 (0.029±0.001). If the magnitude threshold is lowered to m{sub AB} ∼ 27.0, the rate of core-collapse supernovae suitable for time delay observation is 0.044±0.015 per year.

  1. Evaluation of blood pressure and heart rate in patients with hypertension who received tapentadol extended release for chronic pain: a post hoc, pooled data analysis.

    Biondi, David M; Xiang, Jim; Etropolski, Mila; Moskovitz, Bruce


    Hypertension is one of the most common co-existing conditions in patients with chronic pain, and the potential effects of an analgesic on heart rate and blood pressure are of particular concern for patients with hypertension. The purpose of this analysis was to evaluate changes in blood pressure and heart rate with tapentadol extended release (ER) treatment in patients with hypertension. We performed a post hoc analysis of data pooled from three randomized, placebo- and active-controlled, phase III studies of tapentadol ER for managing chronic osteoarthritis knee (NCT00421928, NCT00486811) or low back (NCT00449176) pain (15-week, double-blind treatment period). Data were independently analyzed for patients with a listed medical history of hypertension at baseline and patients with at least one listed concomitant antihypertensive medication at baseline. Heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured at each visit. In patients with a listed medical history of hypertension (n = 1,464), least-squares mean (LSM [standard error (SE)]) changes from baseline to endpoint with placebo, tapentadol ER, and oxycodone HCl controlled release (CR), respectively, were -0.7 (0.44), 0.2 (0.43), and -0.9 (0.45) beats per minute (bpm) for heart rate; -2.4 (0.64), -2.7 (0.64), and -3.7 (0.67) mmHg for SBP; and -1.0 (0.39), -1.3 (0.39), and -2.3 (0.41) mmHg for DBP; in patients with at least one listed concomitant antihypertensive medication (n = 1,376), the LSM (SE) changes from baseline to endpoint were -0.6 (0.45), 0.1 (0.44), and -0.7 (0.47) bpm for heart rate; -1.8 (0.66), -3.3 (0.65), and -3.7 (0.69) mmHg for SBP; and -0.7 (0.40), -1.4 (0.40), and -2.3 (0.42) mmHg for DBP. No clinically meaningful mean changes in heart rate or blood pressure were observed for the evaluated cohorts of patients with hypertension who were treated with tapentadol ER (100-250 mg twice daily).

  2. Rate and time trend of perinatal, infant, maternal mortality, natality and natural population growth in kosovo.

    Azemi, Mehmedali; Gashi, Sanije; Berisha, Majlinda; Kolgeci, Selim; Ismaili-Jaha, Vlora


    THE AIM OF WORK HAS BEEN THE PRESENTATION OF THE RATE AND TIME TRENDS OF SOME INDICATORS OF THE HEATH CONDITION OF MOTHERS AND CHILDREN IN KOSOVO: fetal mortality, early neonatal mortality, perinatal mortality, infant mortality, natality, natural growth of population etc. The treated patients were the newborn and infants in the post neonatal period, women during their pregnancy and those 42 days before and after the delivery. THE DATA WERE TAKEN FROM: register of the patients treated in the Pediatric Clinic of Prishtina, World Health Organization, Mother and Child Health Care, Reproductive Health Care, Ministry of Health of the Republic of Kosovo, Statistical Department of Kosovo, the National Institute of Public Health and several academic texts in the field of pediatrics. Some indicators were analyzed in a period between year 1945-2010 and 1950-2010, whereas some others were analyzed in a time period between year 2000 and 2011. The perinatal mortality rate in 2000 was 29.1‰, whereas in 2011 it was 18.7‰. The fetal mortality rate was 14.5‰ during the year 2000, whereas in 2011 it was 11.0‰, in 2000 the early neonatal mortality was 14.8‰, in 2011 it was 7.5‰. The infant mortality in Kosovo was 164‰ in 1950, whereas in 2010 it was 20.5‰. The most frequent causes of infant mortality have been: lower respiratory tract infections, acute infective diarrhea, perinatal causes, congenital malformations and unclassified conditions. Maternal death rate varied during this time period. Maternal death in 2000 was 23 whereas in 2010 only two cases were reported. Regarding the natality, in 1950 it reached 46.1 ‰, whereas in 2010 it reached 14‰, natural growth of population rate in Kosovo was 29.1‰ in 1950, whereas in 2011 it was 11.0‰. Perinatal mortality rate in Kosovo is still high in comparison with other European countries (Turkey and Kyrgyzstan have the highest perinatal mortality rate), even though it is in a continuous decrease. Infant mortality

  3. Decarbonization rate and the timing and magnitude of the CO2 concentration peak

    Seshadri, Ashwin K.


    Carbon-dioxide (CO2) is the main contributor to anthropogenic global warming, and the timing of its peak concentration in the atmosphere is likely to be the major factor in the timing of maximum radiative forcing. Other forcers such as aerosols and non-CO2 greenhouse gases may also influence the timing of maximum radiative forcing. This paper approximates solutions to a linear model of atmospheric CO2 dynamics with four time-constants to identify factors governing the timing of its concentration peak. The most important emissions-related factor is the ratio between average rates at which emissions increase and decrease, which in turn is related to the rate at which the emissions intensity of CO2 is reduced. Rapid decarbonization of CO2 can not only limit global warming but also achieve an early CO2 concentration peak. The most important carbon cycle parameters are the long multi-century time-constant of atmospheric CO2, and the ratio of contributions to the impulse response function of atmospheric CO2 from the infinitely long lived and the multi-century contributions respectively. Reducing uncertainties in these parameters can reduce uncertainty in forecasts of the radiative forcing peak. A simple approximation for peak CO2 concentration, valid especially if decarbonization is slow, is developed. Peak concentration is approximated as a function of cumulative emissions and emissions at the time of the concentration peak. Furthermore peak concentration is directly proportional to cumulative CO2 emissions for a wide range of emissions scenarios. Therefore, limiting the peak CO2 concentration is equivalent to limiting cumulative emissions. These relationships need to be verified using more complex models of Earth system's carbon cycle.

  4. Surface deformation associated with the 2013 Mw7.7 Balochistan earthquake: Geologic slip rates may significantly underestimate strain release

    Gold, Ryan; Reitman, Nadine; Briggs, Richard; Barnhart, William; Hayes, Gavin


    sections with narrow deformation zones in order to capture the full deformation field. Our results imply that hazard analyses based on geologically-determined fault slip rates (e.g., near-field) should consider the significant and heterogeneous mismatch we document between on- and off-fault coseismic deformation.

  5. Comparison of toxicity and release rates of Cu and Zn from anti-fouling paints leached in natural and artificial brackish seawater.

    Ytreberg, Erik; Karlsson, Jenny; Eklund, Britta


    Biocide-containing anti-fouling paints are regulated and approved according to the added active ingredients, such as Cu. Biocide-free paints are considered to be less environmentally damaging and do not need an approval. Zn, a common ingredient in paints with the potential of causing adverse effects has received only minor attention. Laboratory experiments were conducted in artificial brackish seawater (ASW) and natural brackish seawater (NSW) to quantify release rates of Cu and Zn from biocide-containing and biocide-free labeled eroding anti-fouling paints used on commercial vessels as well as leisure boats. In addition, organisms from three trophic levels, the crustacean Nitocra spinipes, the macroalga Ceramium tenuicorne and the bacteria Vibrio fischeri, were exposed to Cu and Zn to determine the toxicity of these metals. The release rate of Cu in NSW was higher from the paints for professional use (3.2-3.6 microg cm(-)(2)d(-1)) than from the biocide leaching leisure boat paint (1.1 microg cm(-)(2)d(-1)). Biocide-free paints did leach considerably more Zn (4.4-8.2 microg cm(-)(2)d(-1)) than biocide-containing leisure boat paint (3.0 microg cm(-)(2)d(-1)) and ship paints (0.7-2.0 microg cm(-)(2)d(-1)). In ASW the release rates of both metals were notably higher than in NSW for most tested paints. The macroalga was the most sensitive species to both Cu (EC(50)=6.4 microg l(-1)) and Zn (EC(50)=25 microg l(-1)) compared to the crustacean (Cu, LC(50)=2000 microg l(-1) Zn, LC(50)=890 microg l(-1)), and the bacteria (Cu, EC(50)=800 microg l(-1) and Zn, EC(50)=2000 microg l(-1)). The results suggest that the amounts of Zn and Cu leached from anti-fouling paints may attain toxic concentrations in areas with high boat density. To fully account for potential ecological risk associated with anti-fouling paints, Zn as well as active ingredients should be considered in the regulatory process.

  6. Remission Rate and Functional Outcomes During a 6-Month Treatment With Osmotic-Release Oral-System Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder.

    Su, Yi; Li, Haibo; Chen, Yixin; Fang, Fang; Xu, Tong; Lu, Haiping; Xie, Ling; Zhuo, Jianmin; Qu, Jiazhi; Yang, Li; Wang, Yufeng


    Many definitions have been used to evaluate remission in patients with attention-deficit/hyperactivity disorder (ADHD) in different studies resulting with varied remission rates. This open-label, multicenter study investigated the remission rate in Chinese children (n = 239; aged 6-16 years) with a diagnosis of ADHD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), treated with osmotic-release oral-system methylphenidate at doses of 18, 36, and 54 mg, once daily. Two definitions of remission were used: (1) (primary end point): average scores of SNAP-IV (Swanson, Nolan, and Pelham, Fourth Edition) items of 1 or less (0-3 rating scale for each item) according to the subtype of ADHD (inattentive [1-9], hyperactive-impulsive [10-18], and combined type [1-18]), and (2) total score of SNAP-IV items 1 to 18 of 18 or less, at week 8. The study consisted of screening/baseline, titration/open-label treatment (8 weeks), and extended observation (up to 24 weeks) phases. Secondary efficacy assessments were Clinical Global Impression-Improvement (clinical efficacy), Behavior Rating Inventory of Executive Function Scale (BRIEF; executive function behaviors), and Weiss Functional Impairment Rating Scale (social function). Validity of remission was assessed by comparing the function measures (BRIEF and Weiss's) between patients who achieved remission and those who did not. At week 8, 69.3% (151/218) of patients achieved remission by definition 1, and 73.2% (161/220) by definition 2. At weeks 8 and 24, the remission group had significantly lower BRIEF, Weiss's, and Clinical Global Impression-Improvement scores (P methylphenidate was well tolerated, with increased remission rates in children with ADHD.

  7. Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?

    Ren, Jianzhi; Sha, Aiguo; Han, Dongmei; Li, Ping; Geng, Jie; Ma, Chaihui


    To evaluate the effects of a prolonged duration of gonadotropin-releasing hormone agonist (GnRH-a) in pituitary down-regulation for controlled ovarian hyperstimulation (COH) on the live-birth rate in nonendometriotic women undergoing in vitro fertilization and embryo transfer (IVF-ET). Retrospective cohort study. University-affiliated hospital. Normogonadotropic women undergoing IVF. Three hundred seventy-eight patients receiving a prolonged pituitary down-regulation with GnRH-a before ovarian stimulation and 422 patients receiving a GnRH-a long protocol. Live-birth rate per fresh ET. In comparison with the long protocol, the prolonged down-regulation protocol required a higher total dose of gonadotropins. A lower serum luteinizing hormone (LH) level on the starting day of gonadotropin and the day of human chorionic gonadotropin (hCG) and a fewer number of oocytes and embryos were observed in the prolonged down-regulation protocol. However, the duration of stimulation and number of high-quality embryos were comparable between the two groups. A statistically significantly higher implantation rate (50.27% vs. 39.69%), clinical pregnancy rate (64.02% vs. 56.87%) and live-birth rate per fresh transfer cycle (55.56% vs. 45.73%) were observed in the prolonged protocol. Prolonged down-regulation in a GnRH-a protocol might increase the live-birth rates in normogonadotropic women. Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  8. [Time trend of the rates of cesarean and vaginal delivery according to the source of financing].

    Paris, Gisele Ferreira; Monteschio, Lorenna Vlccentine Coutinho; de Oliveira, Rosana Rosseto; Latorre, Maria do Rosário Dias de Oliveira; Pelloso, Sandra Marisa; Mathias, Thais Aidar de Freitas


    To analyze the time trend of the rates of cesarean and vaginal delivery according to the source of financing. This was an ecological study of the time series analysis of cesarean and vaginal delivery rates according to the financing source, carried out in Maringá, Paraná State, Brazil, from 2002 to 2012. Information available at the System of Information on Live Births and at the System of Hospital Information of the Brazilian Unified Health System (SUS) was used for data collection. Moving averages were calculated for all mode of delivery rates in order to smooth random fluctuations in the series, dispersion diagrams were designed between the coefficients and years of the study, and polynomial regression models were estimated from the functional relation observed, with the level of significance set at pdelivery and only 22.9% by vaginal delivery. A total of 22,366 procedures were financed by SUS, 54.6% of them being cesareans. Trend analysis was significant for all the regression models, demonstrating an ascending trend for cesarean delivery and a descending trend for vaginal delivery for both types of financing. The non-SUS cesarean rates always exceeded 90.0% and were more frequent than the SUS cesarean rates, even with a 36.0% increase of the latter during the study period. Based on trend analysis, cesarean deliveries will continue to increase in both health financing sources unless new actions and strategies of reduction are implemented, involving the sociocultural, demographic and obstetric characteristics of women, the training and activity of professionals in the area of obstetrics and an adequate structure of health services for providing vaginal delivery.

  9. Dynamic temperature estimation and real time emergency rating of transmission cables

    Olsen, R. S.; Holboll, J.; Gudmundsdottir, Unnur Stella


    enables real time emergency ratings, such that the transmission system operator can make well-founded decisions during faults. Hereunder is included the capability of producing high resolution loadability vs. time schedules within few minutes, such that the TSO can safely control the system.......This paper is concerned with the development of a fast computational methodology for dynamical estimation of the temperature in transmission cables solely based on current measurements and an enhanced version of the lumped parameters model, also denoted thermo electric equivalents (TEE......). It is found that the calculated temperature estimations are fairly accurate — within 1.5oC of the finite element method (FEM) simulation to which it is compared — both when looking at the temperature profile (time dependent) and the temperature distribution (geometric dependent). The methodology moreover...

  10. Dynamically Switching among Bundled and Single Tickets with Time-Dependent Demand Rates

    Serhan Duran


    Full Text Available The most important market segmentation in sports and entertainment industry is the competition between customers that buy bundled and single tickets. A common selling practice is starting the selling season with bundled ticket sales and switching to selling single tickets later on. The aim of this practice is to increase the number of customers that buy bundles, which in return increases the load factor of the events with low demand. In this paper, we investigate the effect of time dependent demand on dynamic switching times from bundled to single ticket sales and the potential revenue gain over the case where the demand rate of events is assumed to be constant with time.

  11. Adaptive multi-rate interface: development and experimental verification for real-time hybrid simulation

    Maghareh, Amin; Waldbjørn, Jacob Paamand; Dyke, Shirley J.;


    Real-time hybrid simulation (RTHS) is a powerful cyber-physical technique that is a relatively cost-effective method to perform global/local system evaluation of structural systems. A major factor that determines the ability of an RTHS to represent true system-level behavior is the fidelity...... it employs different time steps in the numerical and the physical substructures while including rate-transitioning to link the components appropriately. Typically, a higher-order numerical substructure model is solved at larger time intervals, and is coupled with a physical substructure that is driven...... frequency between the numerical and physical substructures and for input signals with high-frequency content. Further, it does not induce signal chattering at the coupling frequency. The effectiveness of AMRI is also verified experimentally....

  12. Rainfall timing and poultry litter application rate effects on phosphorus loss in surface runoff.

    Schroeder, P D; Radcliffe, D E; Cabrera, M L


    Phosphorus (P) in runoff from pastures amended with poultry litter may be a significant contributor to eutrophication of lakes and streams in Georgia and other areas in the southeastern United States. The objectives of this research were to determine the effects of litter application rate and initial runoff timing on the long-term loss of P in runoff from surface-applied poultry litter and to develop equations that predict P loss in runoff under these conditions. Litter application rates of 2, 7, and 13 Mg ha(-1), and three rainfall scenarios applied to 1- x 2-m plots in a 3 x 3 randomized complete block design with three replications. The rainfall scenarios included (i) sufficient rainfall to produce runoff immediately after litter application; (ii) no rainfall for 30 d after litter application; and (iii) small rainfall events every 7 d (5 min at 75 mm h(-1)) for 30 d. Phosphorus loss was greatest from the high litter rate and immediate runoff treatments. Nonlinear regression equations based on the small plot study produced fairly accurate (r(2) = 0.52-0.62) prediction of P concentrations in runoff water from larger (0.75 ha) fields over a 2-yr period. Predicted P concentrations were closest to observed values for events that occurred shortly after litter application, and the relative error in predictions increased with time after litter application. In addition, previously developed equations relating soil test P levels to runoff P concentrations were ineffective in the presence of surface-applied litter.

  13. Timing and Variability of Galactose Metabolic Gene Activation Depend on the Rate of Environmental Change.

    Truong D Nguyen-Huu


    Full Text Available Modulation of gene network activity allows cells to respond to changes in environmental conditions. For example, the galactose utilization network in Saccharomyces cerevisiae is activated by the presence of galactose but repressed by glucose. If both sugars are present, the yeast will first metabolize glucose, depleting it from the extracellular environment. Upon depletion of glucose, the genes encoding galactose metabolic proteins will activate. Here, we show that the rate at which glucose levels are depleted determines the timing and variability of galactose gene activation. Paradoxically, we find that Gal1p, an enzyme needed for galactose metabolism, accumulates more quickly if glucose is depleted slowly rather than taken away quickly. Furthermore, the variability of induction times in individual cells depends non-monotonically on the rate of glucose depletion and exhibits a minimum at intermediate depletion rates. Our mathematical modeling suggests that the dynamics of the metabolic transition from glucose to galactose are responsible for the variability in galactose gene activation. These findings demonstrate that environmental dynamics can determine the phenotypic outcome at both the single-cell and population levels.

  14. Photothermal damage is correlated to the delivery rate of time-integrated temperature

    Denton, Michael L.; Noojin, Gary D.; Gamboa, B. Giovanna; Ahmed, Elharith M.; Rockwell, Benjamin A.


    Photothermal damage rate processes in biological tissues are usually characterized by a kinetics approach. This stems from experimental data that show how the transformation of a specified biological property of cells or biomolecule (plating efficiency for viability, change in birefringence, tensile strength, etc.) is dependent upon both time and temperature. However, kinetic methods require determination of kinetic rate constants and knowledge of substrate or product concentrations during the reaction. To better understand photothermal damage processes we have identified temperature histories of cultured retinal cells receiving minimum lethal thermal doses for a variety of laser and culture parameters. These "threshold" temperature histories are of interest because they inherently contain information regarding the fundamental thermal dose requirements for damage in individual cells. We introduce the notion of time-integrated temperature (Tint) as an accumulated thermal dose (ATD) with units of °C s. Damaging photothermal exposure raises the rate of ATD accumulation from that of the ambient (e.g. 37 °C) to one that correlates with cell death (e.g. 52 °C). The degree of rapid increase in ATD (ΔATD) during photothermal exposure depends strongly on the laser exposure duration and the ambient temperature.

  15. Linear genetic programming for time-series modelling of daily flow rate

    Aytac Guven


    In this study linear genetic programming (LGP),which is a variant of Genetic Programming,and two versions of Neural Networks (NNs)are used in predicting time-series of daily flow rates at a station on Schuylkill River at Berne,PA,USA.Daily flow rate at present is being predicted based on different time-series scenarios.For this purpose,various LGP and NN models are calibrated with training sets and validated by testing sets.Additionally,the robustness of the proposed LGP and NN models are evaluated by application data,which are used neither in training nor at testing stage.The results showed that both techniques predicted the flow rate data in quite good agreement with the observed ones,and the predictions of LGP and NN are challenging.The performance of LGP,which was moderately better than NN,is very promising and hence supports the use of LGP in predicting of river flow data.

  16. Magnetic Photon Splitting Computations of Proper-time Rates and Spectra

    Baring, M G; Baring, Matthew G.; Harding, Alice K.


    The splitting of photons in the presence of an intense magnetic field has recently found astrophysical applications in polar cap models of gamma-ray pulsars and in magnetar scenarios for soft gamma repeaters. Numerical computation of the polarization-dependent rates of this third order QED process for arbitrary field strengths and energies below pair creation threshold is difficult: thus early analyses focused on analytic developments and simpler asymptotic forms. The recent astrophysical interest spurred the use of the S-matrix approach by Mentzel, Berg and Wunner to determine splitting rates. In this paper, we present numerical computations of a full proper-time expression for the rate of splitting that was obtained by Stoneham, and is exact up to the pair creation threshold. While the numerical results derived here are in accord with the earlier asymptotic forms due to Adler, our computed rates still differ by as much as factors of 3 from the S-matrix re-evaluation of Wilke and Wunner, reflecting the extre...

  17. Real-time monitoring of spontaneous resonance in heart rate variability.

    Jovanov, Emil


    The resonant characteristic of heart rate variability is usually generated using biofeedback and the external pacing of breathing, which is typically around 6 breaths/min (0.1 Hz), although the exact frequency varies between individuals. It was hypothesized that the actual resonant characteristic of heart rate actually depends on the current psychophysiological state of the subject; therefore, the real-team evaluation of this form of resonance is important for a variety of biofeedback applications. This paper presents an analysis of the spontaneous resonance of heart rate variability generated during singing and non-paced slow breathing after breathing exercises. Two methods for automatic analysis and characterization of heart rate variability resonance in real-time have been presented. The first method uses FFT-based spectral analysis, while the second method calculates the period and amplitude of the RR interval variation during each resonant cycle. The proposed methods were tested on a 45-min record from a chanting session and compared with manually annotated and measured periods.

  18. A discrete-time two-factor model for pricing bonds and interest rate derivatives under random volatility

    Heston, Steven L.; Nandi, Saikat


    This paper develops a discrete-time two-factor model of interest rates with analytical solutions for bonds and many interest rate derivatives when the volatility of the short rate follows a GARCH process that can be correlated with the level of the short rate itself. Besides bond and bond futures, the model yields analytical solutions for prices of European options on discount bonds (and futures) as well as other interest rate derivatives such as caps, floors, average rate options, yield curv...

  19. Transient deformation from daily GPS displacement time series: postseismic deformation, ETS and evolving strain rates

    Bock, Y.; Fang, P.; Moore, A. W.; Kedar, S.; Liu, Z.; Owen, S. E.; Glasscoe, M. T.


    underlying physical mechanisms. (3) We present evolving strain dilatation and shear rates based on the SESES velocities for regional subnetworks as a metric for assigning earthquake probabilities and detection of possible time-dependent deformation related to underlying physical processes.

  20. A fluid response: alpha-amylase reactions to acute laboratory stress are related to sample timing and saliva flow rate

    Nagy, T.; van Lien, R.; Willemsen, G.; Proctor, G.; Effting, M.; Fülöp, M.; Bárdos, G.; Veerman, E.C.I.; Bosch, J.A.


    Salivary alpha-amylase (sAA) is used as a sympathetic (SNS) stress marker, though its release is likely co-determined by SNS and parasympathetic (PNS) activation. The SNS and PNS show asynchronous changes during acute stressors, and sAA responses may thus vary with sample timing. Thirty-four