Sample records for release internal pressure

  1. Tending to Internal Pressure


    As China integrates into the world economy,its economic sustainability and industrial health become more vulnerable to external factors.While China’s grain security comes under intense pressure,thefinancialsectoris confrontedwithloomingrisks.Thecountry’s manufacturingindustryleads the world,but its competitiveness is impeded by a lack of high-end production.Many economists and experts discussed these issues at the 2011 China Economic Security Forum,recently held by the University of International Business and Economics in Beijing.Edited excerpts follow:

  2. Internal pressure sensor

    Dowalo, James A [Blackfoot, ID


    A pressure sensor for sensing changes in pressure in an enclosed vessel may include a first chamber having at least one expandable section therein that allows that first chamber to change in length. A reference member mounted within the first chamber moves as a result of changes in length of the first chamber. A second chamber having an expandable section therein allows the second chamber to change in length in response to changes in pressure in the enclosed vessel. The second chamber is operatively associated with the first chamber so that changes in length of the second chamber result in changes in length of the first chamber. A sensor operatively associated with the reference member detects changes in position of the reference member. Changes in position of the reference member are related to changes in pressure in the enclosed vessel.

  3. Internal pressure fluctuations in coacervates and syneresis

    Mohanty, B.; Bohidar, H. B.


    Syneresis exhibited by a heterogeneous polyampholyte coacervate (polymer-rich phase) is discussed through non-equilibrium statistical thermodynamics. It has been shown that the coacervate phase is associated with fluctuating excess internal pressure that gives rise to syneresis. It is proposed that energy is dissipated to the environment only by the surface of coacervate, whereas in the bulk, gelatin chains only exchange energy with each other with negligible or no dissipation. Consequently, the internal pressure inside the coacervate follows a damped oscillatory behaviour that relaxes slowly with time, independently of amplitude. We connect the volume of the supernatant released with time (exponential relaxation behavior) with the presence of long-lived nonlinear localized modes (the existence of breathers).

  4. Pipes under internal pressure and bending

    Catinaccio, A


    This article covers the general behaviour of a straight uniform pipe, with built-in open ends, subject to internal pressure and in plane bending or curvature. It is intended as a summary of the basic equations driving the unintuitive phenomena of bending and instability of pipes under internal pressure. The analysis covers in addition the investigation of opposite pressure stabilisation effects that can be observed in some orthotropic material pipes like composite pressure hoses.

  5. Internal pressure and solubility parameter as a function of pressure

    Verdier, Sylvain Charles Roland; Andersen, Simon Ivar


    The main goal of this work was to measure the solubility parameter of a complex mixture, such as a crude oil, especially as a function of pressure. Thus, its definition is explained, as well as the main approximations generally used in literature. Then, the internal pressure is investigated, since...... it is presented as an alternative of the solubility parameter. In this work, the assumption that internal pressure is a measure of the physical solubility parameter was made, i.e. representing the dispersion and polar forces. As for the pressure influence, it was seen that internal pressure reaches a maximum...... contrary to solubility parameter. An indirect method was chosen to estimate internal pressure, using thermal expansivities (determined by microcalorimetry) and isothermal compressibilities (determined by density measurements). The uncertainty is within 2% for the expansivity and 0.1% for the density. Five...

  6. Upflow bioreactor with septum and pressure release mechanism

    Hansen, Conly L.; Hansen, Carl S.; Pack, Kevin; Milligan, John; Benefiel, Bradley C.; Tolman, C. Wayne; Tolman, Kenneth W.


    An upflow bioreactor includes a vessel having an inlet and an outlet configured for upflow operation. A septum is positioned within the vessel and defines a lower chamber and an upper chamber. The septum includes an aperture that provides fluid communication between the upper chamber and lower chamber. The bioreactor also includes means for releasing pressure buildup in the lower chamber. In one configuration, the septum includes a releasable portion having an open position and a closed position. The releasable portion is configured to move to the open position in response to pressure buildup in the lower chamber. In the open position fluid communication between the lower chamber and the upper chamber is increased. Alternatively the lower chamber can include a pressure release line that is selectively actuated by pressure buildup. The pressure release mechanism can prevent the bioreactor from plugging and/or prevent catastrophic damage to the bioreactor caused by high pressures.

  7. Prediction of Payload Internal Pressure


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  8. Pressure-morphology relationship of a released carpal tunnel.

    Kim, Dong Hee; Marquardt, Tamara L; Gabra, Joseph N; Shen, Zhilei Liu; Evans, Peter J; Seitz, William H; Li, Zong-Ming


    We investigated morphological changes of a released carpal tunnel in response to variations of carpal tunnel pressure. Pressure within the carpal tunnel is known to be elevated in patients with carpal tunnel syndrome and dependent on wrist posture. Previously, increased carpal tunnel pressure was shown to affect the morphology of the carpal tunnel with an intact transverse carpal ligament (TCL). However, the pressure-morphology relationship of the carpal tunnel after release of the TCL has not been investigated. Carpal tunnel release (CTR) was performed endoscopically on cadaveric hands and the carpal tunnel pressure was dynamically increased from 10 to 120 mmHg. Simultaneously, carpal tunnel cross-sectional images were captured by an ultrasound system, and pressure measurements were recorded by a pressure transducer. Carpal tunnel pressure significantly affected carpal arch area (p 62 mm(2) at 120 mmHg. Carpal arch height, length, and width also significantly changed with carpal tunnel pressure (p carpal tunnel pressure increased, carpal arch height and length increased, but the carpal arch width decreased. Analyses of the pressure-morphology relationship for a released carpal tunnel revealed a nine times greater compliance than that previously reported for a carpal tunnel with an intact TCL. This change of structural properties as a result of transecting the TCL helps explain the reduction of carpal tunnel pressure and relief of symptoms for patients after CTR surgery.

  9. International team releases design, cost for next great particle smasher

    Cho, Adrian


    "An internationl team has released a preliminary design and cost estimate for the International Linear Collider (ILC), the hoped-for straight-shot particle smasher that many researchers say is the future of their field."

  10. 49 CFR 195.106 - Internal design pressure.


    ... 49 Transportation 3 2010-10-01 2010-10-01 false Internal design pressure. 195.106 Section 195.106... PIPELINE Design Requirements § 195.106 Internal design pressure. (a) Internal design pressure for the pipe... pressure in p.s.i. (kPa) gage. S=Yield strength in pounds per square inch (kPa) determined in accordance...

  11. Internal jugular pressure increases during parabolic flight.

    Martin, David S; Lee, Stuart M C; Matz, Timothy P; Westby, Christian M; Scott, Jessica M; Stenger, Michael B; Platts, Steven H


    One hypothesized contributor to vision changes experienced by >75% of International Space Station astronauts is elevated intracranial pressure (ICP). While no definitive data yet exist, elevated ICP might be secondary to the microgravity-induced cephalad fluid shift, resulting in venous congestion (overfilling and distension) and inhibition of cerebrospinal and lymphatic fluid drainage from the skull. The objective of this study was to measure internal jugular venous pressure (IJVP) during normo- and hypo-gravity as an index of venous congestion. IJVP was measured noninvasively using compression sonography at rest during end-expiration in 11 normal, healthy subjects (3 M, 8 F) during normal gravity (1G; supine) and weightlessness (0G; seated) produced by parabolic flight. IJVP also was measured in two subjects during parabolas approximating Lunar (1/6G) and Martian gravity (1/3G). Finally, IJVP was measured during increased intrathoracic pressure produced using controlled Valsalva maneuvers. IJVP was higher in 0G than 1G (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, mean ± SD P < 0.001) in all subjects, and IJVP increased as gravity levels decreased in two subjects. Finally, IJVP was greater in 0G than 1G at all expiration pressures (P < 0.01). Taken together, these data suggest that IJVP is elevated during acute exposure to reduced gravity and may be elevated further by conditions that increase intrathoracic pressure, a strong modulator of central venous pressure and IJVP However, whether elevated IJVP, and perhaps consequent venous congestion, observed during acute microgravity exposure contribute to vision changes during long-duration spaceflight is yet to be determined. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  12. Strategies to Mitigate Ammonia Release on the International Space Station

    Macatangay, Ariel V.; Prokhorov, Kimberlee S.; Sweterlitsch, Jeffrey J.


    International Space Station (ISS) is crucial to its continuous operation. Off-nominal situations can arise from virtually any aspect of ISS operations. One situation of particular concern is the inadvertent release of a chemical into the ISS atmosphere. In sufficient quantities, a chemical release can render the ISS uninhabitable regardless of the chemical s toxicity as a result of its effect on the hardware used to maintain the environment. This is certainly true with system chemicals which are integral components to the function and purpose of the system. Safeguards, such as design for minimum risk, multiple containment, hazard assessments, rigorous safety reviews, and others, are in place to minimize the probability of a chemical release to the ISS environment thereby allowing the benefits of system chemicals to outweigh the risks associated with them. The thermal control system is an example of such a system. Heat generated within the ISS is transferred from the internal thermal control system (ITCS) to the external thermal control system (ETCS) via two, single-barrier interface heat exchangers (IFHX). The ITCS and ETCS are closed-loop systems which utilize water and anhydrous ammonia, respectively, as heat-transfer fluids. There is approximately 1200 lbs. (208 gallons) of anhydrous ammonia in the ETCS circulating through the two heat exchangers, transferring heat from the ITCS water lines. At the amounts present in the ETCS, anhydrous ammonia is one system chemical that can easily overwhelm the station atmosphere scrubbing capabilities and render the ISS uninhabitable in the event of a catastrophic rupture. Although safeguards have certainly minimized the risk of an ammonia release into the Station atmosphere, credible release scenarios and controls to manage these scenarios are examined.

  13. "The blood pressure and dermal sensitivity effects of Nylon hollow fiber releasing Glycerin Trinitrate in vivo "

    "Ostad SN


    Full Text Available In order to improve patient's compliance in taking glycerine trinitrate (GTN nylon hollow fiber which has been successfully used for release of chlorhexidine diacetate and levonorgestrel was employed to make nylon hollow fiber releasing GTN. Hollow nylon fibres of external diameter 0.63 mm, 75 mm long with an internal capacity of 16 μl, were filled with GTN (190 mg/ml in 70% ethanol (v/v or vehicle alone and the ends were heat-sealed. The fibers were then immersed in 10 ml of 0.9% (w/v saline in a separating funnel. The GTN release pattern from fiber, the effect of the product on blood pressure and its potential dermal toxicity were assessed. The release of GTN from the fibres was approximately 2.7 μg/min when the fibres contained 16 mg of drug. The results showed that the amount of GTN within the single fibre was enough to reduce blood pressure significantly, while it did not show significant dermal toxicity. It is concluded that GTN fiber, if used as monofilament, is not an alternative method for GTN delivery.

  14. Airway pressure release ventilation and successful lung donation.

    Hanna, Kenny; Seder, Christopher W; Weinberger, Jeffrey B; Sills, Patty A; Hagan, Michael; Janczyk, Randy J


    Donor management with airway pressure release ventilation (APRV) improves oxygenation and increases lung donation while maintaining equivalent graft survival. Retrospective case series. Private, tertiary care, level I trauma center. Forty-five consecutive organ donors. Management with assist/control ventilation (ACV) or APRV. Demographic characteristics, medical history, mode of brain death, and partial pressure of arterial oxygen (Pao(2))/fraction of inspired oxygen (Fio(2)) ratios on admission and after 100% oxygen challenge, percentage of lungs transplanted, and graft survival. Twenty potential donors were managed with ACV and 25 were managed with APRV during the study period. The APRV patients were younger than the ACV patients (mean [SD] age, 34 [11] vs 41 [12] years, respectively; P = .05). Otherwise, there was no difference between the ACV and APRV groups with respect to demographic characteristics, medical history, or mode of brain death. Although the ACV and APRV groups had similar Pao(2)/Fio(2) ratios on admission and the mean time on the ventilator was the same, the APRV group had a higher Pao(2)/Fio(2) ratio than the ACV group (mean [SD], 498 [43] vs 334 [104] mm Hg, respectively; P ACV group ultimately donated 7 of 40 potential lungs (18%) compared with 42 of 50 potential lungs (84%) in the APRV group (P ACV compared favorably with national averages. The use of APRV prior to procurement may increase the rate of successful lung donation.

  15. Release of copper-amended particles from micronized copper-pressure-treated wood during mechanical abrasion

    Civardi, Chiara; Schlagenhauf, Lukas; Kaiser, Jean-Pierre; Hirsch, Cordula; Mucchino, Claudio; Wichser, Adrian; Wick, Peter; Schwarze, Francis W. M. R.


    Background We investigated the particles released due to abrasion of wood surfaces pressure-treated with micronized copper azole (MCA) wood preservative and we gathered preliminary data on its in vitro cytotoxicity for lung cells. The data were compared with particles released after abrasion of untreated, water (0% MCA)-pressure-treated, chromated copper (CC)-pressure-treated wood, and varnished wood. Size, morphology, and composition of the released particles were analyzed. Results Our resul...

  16. Opposing effects of narcotic gases and pressure on the striatal dopamine release in rats.

    Balon, Norbert; Kriem, Badreddine; Dousset, Erick; Weiss, Michel; Rostain, Jean-Claude


    Nitrogen-oxygen breathing mixtures, for pressures higher than 0.5 MPa, decrease the release of dopamine in the rat striatum, due to the narcotic potency of nitrogen. In contrast, high pressures of helium-oxygen breathing mixtures of more than 1-2 MPa induce an increase of the striatal dopamine release and an enhancement of motor activity, referred to as the high pressure nervous syndrome (HPNS), and attributed to the effect of pressure per se. It has been demonstrated that the effect of pressure could be antagonized by narcotic gas in a ternary mixture, but most of the narcotic gas studies measuring DA release were executed below the threshold for pressure effect. To examine the effect of narcotic gases at pressure on the rat striatal dopamine release, we have used two gases, with different narcotic potency, at sublethargic pressure, nitrogen at 3 MPa and argon at 2 MPa. In addition, to dissociate the effect of the pressure, we have used nitrous oxide at 0.1 MPa to induce narcosis at very low pressure, and helium at 8 MPa to study the effect of pressure per se. In all the narcotic conditions we have recorded a decrease of the striatal dopamine release. In contrast, helium pressure induced an increase of DA release. For the pressures used, the results suggest that the decrease of dopamine release was independent of such an effect of the pressure. However, for the same narcotic gas, the measurements of the extracellular DA performed in the striatum seem to reflect an opposing effect of pressure, since the decrease in DA release is lower with increasing pressure.

  17. Photoelastic stress analysis in mitred bend under internal pressure

    Sawa, Yoshiaki


    The stress analysis and stress relaxation in mitred bend subjected to internal pressure have been studied by means of the photoelastic stress freezing method. The experimental results show that stress concentration occurs in the wedge tip of the intersectional plane and it is considerably influenced by the bent angle. Then, the stress relaxation was obtained by planing the wedge tip.

  18. Rod internal pressure quantification and distribution analysis using Frapcon

    Jessee, Matthew Anderson [ORNL; Wieselquist, William A [ORNL; Ivanov, Kostadin [Pennsylvania State University, University Park


    This report documents work performed supporting the Department of Energy (DOE) Office of Nuclear Energy (NE) Fuel Cycle Technologies Used Fuel Disposition Campaign (UFDC) under work breakdown structure element, ST Analysis. In particular, this report fulfills the M4 milestone M4FT- 15OR0810036, Quantify effects of power uncertainty on fuel assembly characteristics, within work package FT-15OR081003 ST Analysis-ORNL. This research was also supported by the Consortium for Advanced Simulation of Light Water Reactors (, an Energy Innovation Hub ( for Modeling and Simulation of Nuclear Reactors under U.S. Department of Energy Contract No. DE-AC05-00OR22725. The discharge rod internal pressure (RIP) and cladding hoop stress (CHS) distributions are quantified for Watts Bar Nuclear Unit 1 (WBN1) fuel rods by modeling core cycle design data, operation data (including modeling significant trips and downpowers), and as-built fuel enrichments and densities of each fuel rod in FRAPCON-3.5. A methodology is developed which tracks inter-cycle assembly movements and assembly batch fabrication information to build individual FRAPCON inputs for each evaluated WBN1 fuel rod. An alternate model for the amount of helium released from the zirconium diboride (ZrB2) integral fuel burnable absorber (IFBA) layer is derived and applied to FRAPCON output data to quantify the RIP and CHS for these types of fuel rods. SCALE/Polaris is used to quantify fuel rodspecific spectral quantities and the amount of gaseous fission products produced in the fuel for use in FRAPCON inputs. Fuel rods with ZrB2 IFBA layers (i.e., IFBA rods) are determined to have RIP predictions that are elevated when compared to fuel rod without IFBA layers (i.e., standard rods) despite the fact that IFBA rods often have reduced fill pressures and annular fuel pellets. The primary contributor to elevated RIP predictions at burnups less than and greater than 30 GWd

  19. Ignition during hydrogen release from high pressure into the atmosphere

    Oleszczak, P.; Wolanski, P.


    The first investigations concerned with a problem of hydrogen jet ignition, during outflow from a high-pressure vessel were carried out nearly 40 years ago by Wolanski and Wojcicki. The research resulted from a dramatic accident in the Chorzow Chemical Plant Azoty, where the explosion of a synthesis gas made up of a mixture composed of three moles of hydrogen per mole of nitrogen, at 300°C and 30 MPa killed four people. Initial investigation had excluded potential external ignition sources and the main aim of the research was to determine the cause of ignition. Hydrogen is currently considered as a potential fuel for various vehicles such as cars, trucks, buses, etc. Crucial safety issues are of potential concern, associated with the storage of hydrogen at a very high pressure. Indeed, the evidence obtained nearly 40 years ago shows that sudden rupture of a high-pressure hydrogen storage tank or other component can result in ignition and potentially explosion. The aim of the present research is identification of the conditions under which hydrogen ignition occurs as a result of compression and heating of the air by the shock wave generated by discharge of high-pressure hydrogen. Experiments have been conducted using a facility constructed in the Combustion Laboratory of the Institute of Heat Engineering, Warsaw University of Technology. Tests under various configurations have been performed to determine critical conditions for occurrence of high-pressure hydrogen ignition. The results show that a critical pressure exists, leading to ignition, which depends mainly on the geometric configuration of the outflow system, such as tube diameter, and on the presence of obstacles.

  20. Modified drug release using atmospheric pressure plasma deposited siloxane coatings

    Dowling, D. P.; Maher, S.; Law, V. J.; Ardhaoui, M.; Stallard, C.; Keenan, A.


    This pilot study evaluates the potential of atmospheric plasma polymerised coatings to modify the rate of drug release from polymeric substrates. The antibiotic rifampicin was deposited in a prototype multi-layer drug delivery system, consisting of a nebulized layer of active drug between a base layer of TEOS deposited on a plastic substrate (polystyrene) and an overlying layer of plasma polymerised PDMS. The polymerised TEOS and PDMS layers were deposited using a helium atmospheric plasma jet system. Elution of rifampicin was measured using UV-VIS spectroscopy, in addition to a antimicrobial well diffusion assay with an established indicator organism. The multi-layered plasma deposited coatings significantly extended the duration of release of the rifampicin from 24 h for the uncoated polymer to 144 h for the coated polymer.

  1. International certification in developing countries: the role of internal and external institutional pressure.

    Fikru, Mahelet G


    This paper examines the different internal and external institutional factors that affect the decision of businesses in developing countries to adopt international certification (IC). Past studies focus on pressure from international laws, the role of multinationals, and businesses mimicking practices of their counterparts in developed countries. This paper finds that, in addition to these external factors, internal factors may have a significant role. Even though environmental regulation is weak in developing countries, governments do not ignore industrial pollution and casualties. They respond by increasing bureaucratic regulations for businesses and this can affect the decision to adopt IC. Furthermore, internal pressure may come from workers' unions that push for a safe and healthy working environment.

  2. Numerical analysis of accidental hydrogen releases from high pressure storage at low temperatures

    Markert, Frank; Melideo, Daniele; Baraldi, Daniele


    ) and temperatures (down to 20 K), e.g. cryogenic compressed gas storage covers pressures up to 35 MPa and temperatures between 33 K and 338 K. Accurate calculations of high pressure releases require real gas EOS. This paper compares a number of EOS to predict hydrogen properties typical in different storage types...

  3. Numerical simulation of high pressure release and dispersion of hydrogen into air with real gas model

    Khaksarfard, R.; Kameshki, M. R.; Paraschivoiu, M.


    Hydrogen is a renewable and clean source of energy, and it is a good replacement for the current fossil fuels. Nevertheless, hydrogen should be stored in high-pressure reservoirs to have sufficient energy. An in-house code is developed to numerically simulate the release of hydrogen from a high-pressure tank into ambient air with more accuracy. Real gas models are used to simulate the flow since high-pressure hydrogen deviates from ideal gas law. Beattie-Bridgeman and Abel Noble equations are applied as real gas equation of state. A transport equation is added to the code to calculate the concentration of the hydrogen-air mixture after release. The uniqueness of the code is to simulate hydrogen in air release with the real gas model. Initial tank pressures of up to 70 MPa are simulated.

  4. Grain boundary cavity growth under applied stress and internal pressure

    Mancuso, J.F.


    The growth of grain boundary cavities under applied stress and internal gas pressure was investigated. Methane gas filled cavities were produced by the C + 4H reversible CH4 reaction in the grain boundaries of type 270 nickel by hydrogen charging in an autoclave at 500/sup 0/C with a hydrogen pressure of either 3.4 or 14.5 MPa. Intergranular fracture of nickel was achieved at a charging temperature of 300/sup 0/C and 10.3 MPa hydrogen pressure. Cavities on the grain boundaries were observed in the scanning electron microscope after fracture. Photomicrographs of the cavities were produced in stereo pairs which were analyzed so as to correct for perspective distortion and also to determine the orientational dependence of cavity growth under an applied tensile stress.

  5. Simulated Internal Storage Buildup, Release, and Runoff from Greenland Ice Sheet at Kangerlussuaq, West Greenland

    Mernild, S. H.; Liston, G. E.; van den Broeke, M.R.


    This study focused on simulated glacier surface conditions (simulated Surface Melt and liquid Precipitation available for supra-, en-, sub-, and proglacial flow processes [after vertical percolation and potential storage within the snowpack] [henceforth SMP]), internal water storage and release, and

  6. Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure.

    Elliott, Paul; Kesteloot, Hugo; Appel, Lawrence J; Dyer, Alan R; Ueshima, Hirotsugu; Chan, Queenie; Brown, Ian J; Zhao, Liancheng; Stamler, Jeremiah


    Raised blood pressure is a leading cause of morbidity and mortality worldwide; improved nutritional approaches to population-wide prevention are required. Few data are available on dietary phosphorus and blood pressure and none are available on possible combined effects of phosphorus, magnesium, and calcium on blood pressure. The International Study of Macro- and Micro-Nutrients and Blood Pressure is a cross-sectional epidemiologic study of 4680 men and women ages 40 to 59 from 17 population samples in Japan, China, United Kingdom, and United States. Blood pressure was measured 8 times at 4 visits. Dietary intakes were obtained from four 24-hour recalls plus data on supplement use. Dietary phosphorus was inversely associated with blood pressure in a series of predefined multiple regression models, with the successive addition of potential confounders, both nondietary and dietary. Estimated blood pressure differences per 232 mg/1000 kcal (2 SD) of higher dietary phosphorus were -1.1 to -2.3 mm Hg systolic/-0.6 to -1.5 mm Hg diastolic (n=4680) and -1.6 to -3.5 mm Hg systolic/-0.8 to -1.8 mm Hg diastolic for 2238 "nonintervened" individuals, ie, those without special diet/nutritional supplements or diagnosis/treatment for cardiovascular disease or diabetes. Dietary calcium and magnesium, correlated with phosphorus (partial r=0.71 and r=0.68), were inversely associated with blood pressure. Blood pressures were lower by 1.9 to 4.2 mm Hg systolic/1.2 to 2.4 mm Hg diastolic for people with intakes above versus below country-specific medians for all 3 of the minerals. These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension.

  7. Stresses Analysis of Petroleum Pipe Finite Element under Internal Pressure



    Full Text Available This paper described the results of a nonlinear static mode within ANSYS of elastic and elastic-plastic behaviour of thin petroleum pipe that is subjected to an internal pressure and therefore a linear stress analysis performed using ANSYS 9.0 finite element software Such an analysis is important because the shape of most structures under internal pressure is cylindrical[1]. In this paper is considered only. Elastic and elastic-plastic finite element analysis is used to predict the principle stresses, effective stress results are compared with those obtained from theatrical equations in order to predict the limit and failure loads for this type of loading also the relationships between redial, hoop stresses and displacement has been used to develop a through understanding. The analysis was completed using ANAYS Version 9.0. (a finite element program for Microsoft Windows NT. The program allows pre-processing, analysis and post-processing stages to be completed within a single application. The program can be used to model a large number of situations including buckling, plastic deformation, forming and stress analysis problems. r mm (In this study ,a thin pipe of internal radiu ri 596 .9 mmand of externalo 609 .6objected to aninternal pressure 2 i  4 .83  / mm which is gradually increased to near the ultimate load that may be sustained by the pipe. The pipe is modelled as an elasto-plastic material using the Von Mises yield criterion which is normally used for metallic materials[2]. The specification of the load in several increments enables the spread of the plasticity to occur gradually and its effect on the stress distribution to be assessed. Key words: finite element analysis, elastic-plastic behavior, thin walled pipe equivalent stress, TWT.

  8. Internal hysteresis experienced on a high pressure syn gas compressor

    Zeidan, F. Y.


    A vibration instability phenomenon experienced in operating high pressure syn gas centrifugal compressors in two ammonia plants is described. The compressors were monitored by orbit and spectrum analysis for changes from baseline readings. It is found that internal hysteresis was the major destabilizing force; however, the problem was further complicated by seal lockup at the suction end of the compressor. A coupling lockup problem and a coupling fit problem, which frettage of the shaft, are also considered as contributors to the self excited vibrations.

  9. Upper internals arrangement for a pressurized water reactor

    Singleton, Norman R; Altman, David A; Yu, Ching; Rex, James A; Forsyth, David R


    In a pressurized water reactor with all of the in-core instrumentation gaining access to the core through the reactor head, each fuel assembly in which the instrumentation is introduced is aligned with an upper internals instrumentation guide-way. In the elevations above the upper internals upper support assembly, the instrumentation is protected and aligned by upper mounted instrumentation columns that are part of the instrumentation guide-way and extend from the upper support assembly towards the reactor head in hue with a corresponding head penetration. The upper mounted instrumentation columns are supported laterally at one end by an upper guide tube and at the other end by the upper support plate.

  10. Pressurized-water reactor internals aging degradation study. Phase 1

    Luk, K.H. [Oak Ridge National Lab., TN (United States)


    This report documents the results of a Phase I study on the effects of aging degradations on pr internals. Primary stressers for internals an generated by the primary coolant flow in the they include unsteady hydrodynamic forces and pump-generated pressure pulsations. Other stressors are applied loads, manufacturing processes, impurities in the coolant and exposures to fast neutron fluxes. A survey of reported aging-related failure information indicates that fatigue, stress corrosion cracking (SCC) and mechanical wear are the three major aging-related degradation mechanisms for PWR internals. Significant reported failures include thermal shield flow-induced vibration problems, SCC in guide tube support pins and core support structure bolts, fatigue-induced core baffle water-jet impingement problems and excess wear in flux thimbles. Many of the reported problems have been resolved by accepted engineering practices. Uncertainties remain in the assessment of long-term neutron irradiation effects and environmental factors in high-cycle fatigue failures. Reactor internals are examined by visual inspections and the technique is access limited. Improved inspection methods, especially one with an early failure detection capability, can enhance the safety and efficiency of reactor operations.

  11. Adding a custom made pressure release valve during air enema for intussusception: A new technique

    Hosni Morsi Ahmed


    Full Text Available Background: Non-surgical reduction remains the first line treatment of choice for intussusception. The major complication of air enema reduction is bowel perforation. The authors developed a custom made pressure release valve to be added to portable insufflation devices, delivering air at pressures accepted as safe for effective reduction of intussusception in children under fluoroscopic guidance. The aim of this study was to develop a custom made pressure release valve that is suitable for the insufflation devices used for air enema reduction of intussusception and to put this valve into regular clinical practice. Materials and Methods: An adjustable, custom made pressure release valve was assembled by the authors using readily available components. The valve was coupled to a simple air enema insufflation device. The device was used for the trial of reduction of intussusception in a prospective study that included 132 patients. Results: The success rate for air enema reduction with the new device was 88.2%. The mean pressure required to achieve complete reduction was 100 mmHg. The insufflation pressure never exceeded the preset value (120 mmHg. Of the successful cases, 58.3% were reduced from the first attempt while 36.1% required a second insufflation. Only 5.55% required a third insufflation to complete the reduction. In cases with unsuccessful pneumatic reduction attempt (18.1%, surgical treatment was required. Surgery ranged from simple reduction to resection with a primary end to end anastomosis. No complications from air enema were recorded. Conclusions: The authors recommend adding pressure release valves to ensure safety by avoiding pressure overshoot during the procedure.

  12. Internal Curing Using Water-releasing Material for High Strength Micro-expansive Concrete

    LU Linnu; YANG Wen; HE Yongjia; WU Jing; HU Shuguang


    Due to its low water content,it is difficult for expansive agent to have an effective expansive effect on high strength concrete to compensate its extensive shrinkage and form a certain expansion.To solve this problem,water-releasing material with water storage and releasing characteristics was incorporated into high strength micro-expansive concrete to provide internal curing,and expansive effect of expansive agent was improved.Migration of water from initially saturated water-releasing material to the surrounding hydrating cement paste was investigated.Based on a given efficient diffusion distance of water stored in water-releasing material,the mass and real water-cement ratio of cured cement paste were estimated.At the same time,the effect of internal curing of water-releasing material on the volume deformation of high strength micro-expansive concrete was investigated.

  13. Recyclability of mixed office waste papers containing pressure sensitive adhesives and silicone release liners

    Julie Hess; Roberta Sena-Gomes; Lisa Davie; Marguerite Sykes


    Increased use of pressure sensitive adhesives for labels and stamps has introduced another contaminant into the office paper stream: silicone- coated release liners. This study examines methods and conditions for removal of contaminants, including these liners, from a typical batch of discarded office papers. Removal of contaminants contained in the furnish were...

  14. Real-Time Flavor Release from French Fries Using Atmospheric Pressure Chemical Ionization-Mass Spectrometry

    Loon, W.A.M.; Linssen, J.P.H.; Boelrijk, A.E.M.; Burgering, M.J.M.; Voragen, A.G.J.


    Flavor release from French fries was measured with atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) using both assessors (in vivo) and a mouth model system (in vitro). Several volatiles measured with APCI were identified with MS-MS. The effect of frying time, salt addition, and a

  15. Atrial distension, arterial pulsation, and vasopressin release during negative pressure breathing in humans

    Pump, B; Damgaard, M; Gabrielsen, A


    in eight healthy males, we tested the hypothesis that with similar increases in LA diameter, suppression of AVP release is dependent on the degree of increase in PP. LA diameter increased similarly during the posture change and negative pressure breathing (-9 to -24 mmHg) from between 30 and 31 +/- 1 to 34......During an antiorthostatic posture change, left atrial (LA) diameter and arterial pulse pressure (PP) increase, and plasma arginine vasopressin (AVP) is suppressed. By comparing the effects of a 15-min posture change from seated to supine with those of 15-min seated negative pressure breathing...... +/- 1 mm (P breathing from 36 +/- 3 to 42 +/- 3 mmHg (P

  16. Atrial distension, arterial pulsation, and vasopressin release during negative pressure breathing in humans

    Pump, B; Damgaard, M; Gabrielsen, A;


    During an antiorthostatic posture change, left atrial (LA) diameter and arterial pulse pressure (PP) increase, and plasma arginine vasopressin (AVP) is suppressed. By comparing the effects of a 15-min posture change from seated to supine with those of 15-min seated negative pressure breathing...... in eight healthy males, we tested the hypothesis that with similar increases in LA diameter, suppression of AVP release is dependent on the degree of increase in PP. LA diameter increased similarly during the posture change and negative pressure breathing (-9 to -24 mmHg) from between 30 and 31 +/- 1 to 34...... +/- 1 mm (P breathing from 36 +/- 3 to 42 +/- 3 mmHg (P

  17. Influence of the adenosine A1 receptor on blood pressure regulation and renin release

    Brown, Russell D.; Thorén, Peter; Steege, Andreas


    The present study was performed to investigate the role of adenosine A1 receptors in regulating blood pressure in conscious mice. Adenosine A1-receptor knockout (A1R-/-) mice and their wild-type (A1R+/+) littermates were placed on standardized normal-salt (NS), high-salt (HS), or salt-deficient (SD......) diets for a minimum of 10 days before telemetric blood pressure and urinary excretion measurements in metabolic cages. On the NS diet, daytime and nighttime mean arterial blood pressure (MAP) was 7-10 mmHg higher in A1R-/- than in A1R+/+ mice. HS diet did not affect the MAP in A1R-/- mice....... The elevated plasma renin concentrations found in the A1R-/- mice could also result in increased blood pressure. Our results confirm that adenosine, acting through the adenosine A1 receptor, plays an important role in regulating blood pressure, renin release, and sodium excretion....

  18. The International Pulsar Timing Array: First Data Release

    Verbiest, J P W; Hobbs, G; van Haasteren, R; Demorest, P B; Janssen, G H; Wang, J -B; Desvignes, G; Caballero, R N; Keith, M J; Champion, D J; Arzoumanian, Z; Babak, S; Bassa, C G; Bhat, N D R; Brazier, A; Brem, P; Burgay, M; Burke-Spolaor, S; Chamberlin, S J; Chatterjee, S; Christy, B; Cognard, I; Cordes, J M; Dai, S; Dolch, T; Ellis, J A; Ferdman, R D; Fonseca, E; Gair, J R; Garver-Daniels, N E; Gentile, P; Gonzalez, M E; Graikou, E; Guillemot, L; Hessels, J W T; Jones, G; Karuppusamy, R; Kerr, M; Kramer, M; Lam, M T; Lasky, P D; Lassus, A; Lazarus, P; Lazio, T J W; Lee, K J; Levin, L; Liu, K; Lynch, R S; Lyne, A G; Mckee, J; McLaughlin, M A; McWilliams, S T; Madison, D R; Manchester, R N; Mingarelli, C M F; Nice, D J; Oslowski, S; Palliyaguru, N T; Pennucci, T T; Perera, B B P; Perrodin, D; Possenti, A; Petiteau, A; Ransom, S M; Reardon, D; Rosado, P A; Sanidas, S A; Sesana, A; Shaifullah, G; Shannon, R M; Siemens, X; Simon, J; Smits, R; Spiewak, R; Stairs, I H; Stappers, B W; Stinebring, D R; Stovall, K; Swiggum, J K; Taylor, S R; Theureau, G; Tiburzi, C; Toomey, L; Vallisneri, M; van Straten, W; Vecchio, A; Wang, Y; Wen, L; You, X P; Zhu, W W; Zhu, X -J


    The highly stable spin of neutron stars can be exploited for a variety of (astro-)physical investigations. In particular arrays of pulsars with rotational periods of the order of milliseconds can be used to detect correlated signals such as those caused by gravitational waves. Three such "Pulsar Timing Arrays" (PTAs) have been set up around the world over the past decades and collectively form the "International" PTA (IPTA). In this paper, we describe the first joint analysis of the data from the three regional PTAs, i.e. of the first IPTA data set. We describe the available PTA data, the approach presently followed for its combination and suggest improvements for future PTA research. Particular attention is paid to subtle details (such as underestimation of measurement uncertainty and long-period noise) that have often been ignored but which become important in this unprecedentedly large and inhomogeneous data set. We identify and describe in detail several factors that complicate IPTA research and provide r...

  19. Analysis of laminated composite shells under internal pressure

    Yuan, F. G.


    A closed form solution is presented that predicts the response of filament wound composite shells subjected to internal pressure. The material of the shell is assumed to be general cylindrically anisotropic. Based on the theory of cylindrical anisotropic elasticity coupled differential equations are developed using Lekhnitskii's stress function approach. Two composite systems, graphite/epoxy and glass/epoxy, are selected to demonstrate the influence of degree of material anisotropy and fiber orientations on the axial and induced twisting deformation. Detailed stress distributions of (45) off-axis unidirectional and (45/-45)s symmetric angle-ply fiber-reinforced laminated shells are shown to illustrate the effect of radius-to-thickness ratio and stacking sequence.

  20. Comparison of electrohydraulic lithotripters with rigid and pressure-release ellipsoidal reflectors. II. Cavitation fields.

    Bailey, M R; Blackstock, D T; Cleveland, R O; Crum, L A


    Dramatically different cavitation was produced by two separate acoustic pulses that had different shapes but similar duration, frequency content, and peak positive and negative pressure. Both pulses were produced by a Dornier HM-3 style lithotripter: one pulse when the ellipsoidal reflector was rigid, the other when the reflector was pressure release. The cavitation, or bubble action, generated by the conventional rigid-reflector pulse was nearly 50 times longer lived and 3-13 times stronger than that produced by the pressure-release-reflector pulse. Cavitation durations measured by passive acoustic detection and high-speed video agreed with calculations based on the Gilmore equation. Cavitation intensity, or destructive potential, was judged (1) experimentally by the size of pits in aluminum foil detectors and (2) numerically by the calculated amplitude of the shock wave emitted by a collapsing bubble. The results indicate that the trailing positive spike in the pressure-release-reflector waveform stifles bubble growth and mitigates the collapse, whereas the trough after the positive spike in the rigid-reflector waveform triggers inertially driven growth and collapse. The two reflectors therefore provide a tool to compare effects in weakly and strongly cavitating fields and thereby help assess cavitation's role in lithotripsy.

  1. Biomechanical consequences of adding plantar fascia release to metatarsal osteotomies: Changes in forefoot plantar pressures.

    Aydogan, Umur; Roush, Evan P; Moore, Blake E; Andrews, Seth H; Lewis, Gregory S


    Destruction of the normal metatarsal arch by a long metatarsal is often a cause for metatarsalgia. When surgery is warranted, distal oblique, or proximal dorsiflexion osteotomies of the long metatarsal bones are commonly used. The plantar fascia has anatomical connection to all metatarsal heads. There is controversial scientific evidence on the effect of plantar fascia release on forefoot biomechanics. In this cadaveric biomechanical study, we hypothesized that plantar fascia release would augment the plantar metatarsal pressure decreasing effects of two common second metatarsal osteotomy techniques. Six matched pairs of foot and ankle specimens were mounted on a pressure mat loading platform. Two randomly assigned surgery groups, which had received either distal oblique, or proximal dorsiflexion osteotomy of the second metatarsal, were evaluated before and after plantar fasciectomy. Specimens were loaded up to a ground reaction force of 400 N at varying Achilles tendon forces. Average pressures, peak pressures, and contact areas were analyzed. Supporting our hypothesis, average pressures under the second metatarsal during 600 N Achilles load were decreased by plantar fascia release following proximal osteotomy (p fascia release following modified distal osteotomy, under multiple Achilles loading conditions (p < 0.05). Plantar fasciotomy should not be added to distal metatarsal osteotomy in the treatment of metatarsalgia. If proximal dorsiflexion osteotomy would be preferred, plantar fasciotomy should be approached cautiously not to disturb the forefoot biomechanics. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:800-804, 2017. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  2. Estimation of influence of myofascial release techniques on esophageal pressure in patients after total laryngectomy.

    Marszałek, Sławomir; Zebryk-Stopa, Anna; Kraśny, Jacek; Obrebowski, Andrzej; Golusiński, Wojciech


    In patients after total laryngectomy, increased tension in myofascial neck and arm areas might be observed. Via fascial continuity it has an adverse impact on the superior esophageal constrictor forming the "mouth of the oesophagus", which hinders learning of esophageal speech. The aim is to assess the effect of manual myofascial release techniques on esophageal pressure in patients after total laryngectomy. Forty patients (12 F, 28 M), aged 43-75 (mean 56.8 years), 9 months to 13 years (average 3 years) after total laryngectomy, 35 patients (87.5%) after neck lymph node resection, 38 patients (95%) after radiotherapy. Esophageal pressure was assessed using modified Seeman's method. Manual myofascial release techniques were applied within head, neck, arms, upper trunk and upper limb areas. Wilcoxon and Shapiro-Wilk's test was used for the purpose of statistical analysis. Statistically significant decrease of the mean esophageal pressure was observed after the physiotherapy treatment. The average pressure among the examined patients decreased from 37.9 to 26.6 mmHg. The application of myofascial manual techniques decreases esophageal pressure, thus allowing patients to learn esophagus speech at a faster pace.

  3. Changes in Therapeutic Intensity Level Following Airway Pressure Release Ventilation in Severe Traumatic Brain Injury.

    Fletcher, Jeffrey J; Wilson, Thomas J; Rajajee, Venkatakrishna; Davidson, Scott B; Walsh, Jon C


    Airway pressure release ventilation (APRV) utilizes high levels of airway pressure coupled with brief expiratory release to facilitate open lung ventilation. The aim of our study was to evaluate the effects of APRV-induced elevated airway pressure mean in patients with severe traumatic brain injury. This was a retrospective cohort study at a 424-bed Level I trauma center. Linear mixed effects models were developed to assess the difference in therapeutic intensity level (TIL), intracranial pressure (ICP), and cerebral perfusion pressure (CPP) over time following the application of APRV. The study included 21 epochs of APRV in 21 patients. In the 6-hour epoch following the application of APRV, the TIL was significantly increased (P = .002) and the ICP significantly decreased (P = .041) compared to that before 6 hours. There was no significant change in CPP (P = .42) over time. The baseline static compliance and time interaction was not significant for TIL (χ(2) = 0.2 [df 1], P = .655), CPP (χ(2) = 0 [df 1], P = 1), or ICP (χ(2) = 0.1 [df 1], P = .752). Application of APRV in patients with severe traumatic brain injury was associated with significantly, but not clinically meaningful, increased TIL and decreased ICP. No significant change in CPP was observed. No difference was observed based on the baseline pulmonary static compliance. © The Author(s) 2016.

  4. Investigating Premature Ignition of Thruster Pressure Cartridges by Mechanical Impact of Internal Components

    Woods, Stephen S.; Saulsberry, Regor


    Pyrotechnic thruster pressure cartridges (TPCs) are used for aeroshell separation on a new NASA crew launch vehicle. The premature ignition concern was hypothesized based on the potential range of motion of the subassemblies, projected worst case accelerations, and the internal geometry that could subject propellant grains to mechanical impact sufficiently high for ignition. This possibility was investigated by fabricating a high-fidelity model of the suspected contact geometry, placing a representative amount of propellant in it, and impacting the propellant with a range of forces equivalent to and greater than the maximum possible during launch. Testing demonstrated that the likelihood of ignition is less than 1 in 1,000,000. The test apparatus, methodology, and results are described in this paper. Nondestructive evaluation ( NDE) during TPC acceptance testing indicated that internal assemblies moved during shock and vibration testing due to an internal bond anomaly. This caused concerns that the launch environment might produce the same movement and release propellant grains that might be prematurely ignited through impact or through electrostatic discharge (ESD) as grains vibrated against internal surfaces. Since a new lot could not be fabricated in time, a determination had to be made as to whether the lot was acceptable to fly. This paper discusses the analysis and impact testing used to address the potential impact issue and a separate paper addresses the ESD issue.

  5. Neuronal nitric oxide synthase-deficient mice have impaired Renin release but normal blood pressure

    Sällström, Johan; Carlström, Mattias; Jensen, Boye L


    BackgroundNitric oxide deficiency is involved in the development of hypertension, but the mechanisms are currently unclear. This study was conducted to further elucidate the role of neuronal nitric oxide synthase (nNOS) in blood pressure regulation and renin release in relation to different sodiu......-116; doi:10.1038/ajh.2007.16American Journal of Hypertension (2008) 21 111-116; doi:10.1038/ajh.2007.16....

  6. Evidence for pressure-release melting beneath magmatic arcs from basalt at Galunggung, Indonesia

    Sisson, T.W.; Bronto, S.


    The melting of peridotite in the mantle wedge above subduction zones is generally believed to involve hydrous fluids derived from the subducting slab. But if mantle peridotite is upwelling within the wedge, melting due to pressure release could also contribute to magma production. Here we present measurements of the volatile content of primitive magmas from Galunggung volcano in the Indonesian are which indicate that these magmas were derived from the pressure-release melting of hot mantle peridotite. The samples that we have analysed consist of mafic glass inclusions in high-magnesium basalts. The inclusions contain uniformly low H2O concentrations (0.21-0.38 wt%), yet relatively high levels of CO2 (up to 750 p.p.m.) indicating that the low H2O concentrations are primary and not due to degassing of the magma. Results from previous anhydrous melting experiments on a chemically similar Aleutian basalts indicate that the Galunggung high-magnesium basalts were last in equilibrium with peridotite at ~1,320 ??C and 1.2 GPa. These high temperatures at shallow sub-crustal levels (about 300-600 ??C hotter than predicted by geodynamic models), combined with the production of nearly H2O- free basaltic melts, provide strong evidence that pressure-release melting due to upwelling in the sub-are mantle has taken place. Regional low- potassium and low-H2O (ref. 5) basalts found in the Cascade are indicate that such upwelling-induced melting can be widespread.

  7. An experimental system for release simulation of internal stores in a supersonic wind tunnel

    Wei Liu


    Full Text Available Aerodynamic parameters obtained from separation experiments of internal stores in a wind tunnel are significant in aircraft designs. Accurate wind tunnel tests can help to improve the release stability of the stores and in-flight safety of the aircrafts in supersonic environments. A simulative system for free drop experiments of internal stores based on a practical project is provided in this paper. The system contains a store release mechanism, a control system and an attitude measurement system. The release mechanism adopts a six-bar linkage driven by a cylinder, which ensures the release stability. The structure and initial aerodynamic parameters of the stores are also designed and adjusted. A high speed vision measurement system for high speed rolling targets is utilized to measure the pose parameters of the internal store models and an optimizing method for the coordinates of markers is presented based on a priori model. The experimental results show excellent repeatability of the system, and indicate that the position measurement precision is less than 0.13 mm, and the attitude measurement precision for pitch and yaw angles is less than 0.126°, satisfying the requirements of practical wind tunnel tests. A separation experiment for the internal stores is also conducted in the FL-3 wind tunnel of China Aerodynamics Research Institute.

  8. The 2008 Public Release of the International Multi-tokamak Confinement Profile Database

    Roach, C. M.; Walters, M.; Budny, R. V.; Imbeaux, F.; Fredian, T. W.; Greenwald, M.; Stillerman, J. A.; Alexander, D. A.; Carlsson, J.; Cary, J. R.; Ryter, F.; Stober, J.; Gohil, P.; Greenfield, C.; Murakami, M.; Bracco, G.; Esposito, B.; Romanelli, M.; Parail, V.; Stubberfield, P.; Voitsekhovitch, I.; Brickley, C.; Field, A. R.; Sakamoto, Y.; Fujita, T.; Fukuda, T.; Hayashi, N.; Hogeweij, G. M. D.; Chudnovskiy, A.; Kinerva, N. A.; Kessel, C. E.; Aniel, T.; Hoang, G. T.; Ongena, J.; Doyle, E. J.; Houlberg, W. A.; Polevoi, A. R.


    This paper documents the public release PR08 of the International Tokamak Physics Activity (ITPA) profile database, which should be of particular interest to the magnetic confinement fusion community. Data from a wide variety of interesting discharges from many of the world's leading tokamak ex

  9. The initial responses of hot liquid water released under low atmospheric pressures: Experimental insights

    Bargery, Alistair Simon; Lane, Stephen J.; Barrett, Alexander; Wilson, Lionel; Gilbert, Jennie S.


    Experiments have been performed to simulate the shallow ascent and surface release of water and brines under low atmospheric pressure. Atmospheric pressure was treated as an independent variable and water temperature and vapor pressure were examined as a function of total pressure variation down to low pressures. The physical and thermal responses of water to reducing pressure were monitored with pressure transducers, temperature sensors and visible imaging. Data were obtained for pure water and for solutions with dissolved NaCl or CO 2. The experiments showed the pressure conditions under which the water remained liquid, underwent a rapid phase change to the gas state by boiling, and then solidified because of removal of latent heat. Liquid water is removed from phase equilibrium by decompression. Solid, liquid and gaseous water are present simultaneously, and not at the 611 Pa triple point, because dynamic interactions between the phases maintain unstable temperature gradients. After phase changes stop, the system reverts to equilibrium with its surroundings. Surface and shallow subsurface pressure conditions were simulated for Mars and the icy satellites of the outer Solar System. Freezing by evaporation in the absence of wind on Mars is shown to be unlikely for pure water at pressures greater than c. 670 Pa, and for saline solutions at pressures greater than c. 610 Pa. The physical nature of ice that forms depends on the salt content. Ice formed from saline water at pressures less than c. 610 Pa could be similar to terrestrial sea ice. Ice formed from pure water at pressures less than c. 100 Pa develops a low thermal conductivity and a 'honeycomb' structure created by sublimation. This ice could have a density as low as c. 450 kg m -3 and a thermal conductivity as low as 1.6 W m -1 K -1, and is highly reflective, more akin to snow than the clear ice from which it grew. The physical properties of ice formed from either pure or saline water at low pressures will

  10. Critical velocity of sandwich cylindrical shell under moving internal pressure


    Critical velocity of an infinite long sandwich shell under moving internal pres-sure is studied using the sandwich shell theory and elastodynamics theory. Propagation of axisymmetric free harmonic waves in the sandwich shell is studied using the sandwich shell theory by considering compressibility and transverse shear deformation of the core, and transverse shear deformation of face sheets. Based on the elastodynamics theory, displacement components expanded by Legendre polynomials, and position-dependent elastic constants and densities are introduced into the equations of motion. Critical ve-locity is the minimum phase velocity on the desperation relation curve obtained by using the two methods. Numerical examples and the finite element (FE) simulations are pre-sented. The results show that the two critical velocities agree well with each other, and two desperation relation curves agree well with each other when the wave number κ is relatively small. However, two limit phase velocities approach to the shear wave velocities of the face sheet and the core respectively when k limits to infinite. The two methods are efficient in the investigation of wave propagation in a sandwich cylindrical shell when κ is relatively small. The critical velocity predicted in the FE simulations agrees with theoretical prediction.

  11. Control of neurotransmitter release by an internal gel matrix in synaptic vesicles.

    Reigada, David; Díez-Pérez, Ismael; Gorostiza, Pau; Verdaguer, Albert; Gómez de Aranda, Inmaculada; Pineda, Oriol; Vilarrasa, Jaume; Marsal, Jordi; Blasi, Joan; Aleu, Jordi; Solsona, Carles


    Neurotransmitters are stored in synaptic vesicles, where they have been assumed to be in free solution. Here we report that in Torpedo synaptic vesicles, only 5% of the total acetylcholine (ACh) or ATP content is free, and that the rest is adsorbed to an intravesicular proteoglycan matrix. This matrix, which controls ACh and ATP release by an ion-exchange mechanism, behaves like a smart gel. That is, it releases neurotransmitter and changes its volume when challenged with small ionic concentration change. Immunodetection analysis revealed that the synaptic vesicle proteoglycan SV2 is the core of the intravesicular matrix and is responsible for immobilization and release of ACh and ATP. We suggest that in the early steps of vesicle fusion, this internal matrix regulates the availability of free diffusible ACh and ATP, and thus serves to modulate the quantity of transmitter released.

  12. Depleted internal store-activated Ca2+ entry can trigger neurotransmitter release in bovine chromaffin cells.

    Powis, D A; Clark, C L; O'Brien, K J


    A potential role of the intracellular Ca2+ stores in modulating catecholamine release has been investigated in bovine chromaffin cells maintained in tissue culture. Pharmacological depletion of the stores with a combination of caffeine, histamine and thapsigargin in Ca2+-free media resulted in a significantly greater release of catecholamines on re-exposure to Ca2+-containing media compared with that from non-store depleted cells. The increase in catecholamine release was prevented by intracellular BAPTA indicating that the increase was caused by a rise in Ca2+. Measurement of intracellular free Ca2+ concentration with the fluorescent indicator, fura-2, over the same time-course as the catecholamine release experiments showed that upon restoration of external Ca2+ there was an immediate, substantial and maintained increase in cytosolic Ca2+. It is most probable that the increase in catecholamine release was a consequence of an increase in Ca2+ influx triggered by prior depletion of the internal Ca2+ stores. However, the data suggest that capacitative Ca2+ entry is poorly linked to catecholamine release; although Ca2+ entry on restoration of external Ca2+ was immediate and substantial, the increase in catecholamine release, although quantitatively significant, was slowly realised.

  13. Effect of pressure on the release of endogenous dopamine from rat striatum and the role of sodium-calcium exchange.

    Paul, M L; Philp, R B


    Exposure to environmental pressures in excess of 20 atm abs can precipitate a hyperexcitability state known as high pressure neurologic syndrome (HPNS). Little is known about the underlying neurochemical basis of this syndrome. An in vitro model of the synthesis and release of endogenous dopamine (DA) from rat striatal slices has been used to examine the mechanism underlying the effects of high pressures of He. He at 100 atm abs produced changes in DA release which were strikingly similar to those of the cardiac glycoside, ouabain. Neither pressure nor ouabain (1-10 microM) had any significant effects on the spontaneous (nonevoked) release of DA or its metabolite 3,4-dihydroxyphenylacetic acid, but both pressure and ouabain significantly enhanced the stimulated release of DA which was evoked by a 6-min exposure to 35 mM KCl (P less than 0.05 and P less than 0.001). In both cases, this effect was dependent on the presence of extracellular Ca2+. Augmentation of evoked DA release by both ouabain and He pressure was reversed (P less than 0.05) by 3,4-dichlorobenzamil, a selective antagonist of the membrane Na+/Ca2+ exchange mechanism. The results suggest that pressure exerts its effects on DA release by increasing intracellular-free Ca2+ exchange after pressure-inhibition of the activity of the membrane Na,K-ATPase.

  14. High pressurized CO2 release CFD calculations from onshore pipeline leakages

    Herzog, Nicoleta; Gorenz, Paul; Egbers, Christoph


    Emissions from high pressurized pipelines can be determined on the basis of hydrodynamical and thermophysical calculations of the escaped fluid. If a rupture occurs when CO2 is onshore transported in liquid form there will be initially a large pressure drop in the pipeline, the pressure will fall until the liquid becomes a mixture of saturated vapor/liquid. In the vicinity of the rupture, liquid CO2 will escape and immediately vaporize and expand, some of the liquid will desublimate into dry ice, which will precipitate onto the ground [1, 2]. The period of time taken for a large amount of carbon dioxide to be discharged would be short. Initially CO2 will escape by pushing the overlying soil upwards at an explosion-like speed. After the pressure in the pipe fell the flow profile of the escaping gas will almost be as described for gaseous material transport. The expansion of carbon dioxide will occur at sonic speed and will continue to do so until the pressure ratio between the CO2 and the ambient air is lower than about 1.9 [3]. As a result of the expansion also the temperature of the escaping gas will fall drastically and a cloud of cold gas will form which is then dispersed and slowly mixed with ambient air. The rate of emptying the pipeline is controlled by the pipe cross-section area and the speed of the escaping gas, or by the pressure difference between the pipeline and the atmosphere. Therefore the mass flow will be largest immediately after the accident with an exponential decay in time. In this study a two-phase model is applied to a high pressurized pipeline through which liquid carbon dioxide flows. A leakage is considered to be at different positions along the pipeline and the release pressure is calculated over several parameter ranges. It is also intended to characterize from hydrodynamical point of view the dispersion of released CO2 in the ambient medium by means of CFD simulations which includes multiphase flow treatment. For that a turbulent two

  15. Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis.

    Sipos, Arnold; Vargas, Sarah L; Toma, Ildikó; Hanner, Fiona; Willecke, Klaus; Peti-Peterdi, János


    In the renal tubule, ATP is an important regulator of salt and water reabsorption, but the mechanism of ATP release is unknown. Several connexin (Cx) isoforms form mechanosensitive, ATP-permeable hemichannels. We localized Cx30 to the nonjunctional apical membrane of cells in the distal nephron and tested whether Cx30 participates in physiologically important release of ATP. We dissected, partially split open, and microperfused cortical collecting ducts from wild-type and Cx30-deficient mice in vitro. We used PC12 cells as ATP biosensors by loading them with Fluo-4/Fura Red to measure cytosolic calcium and positioning them in direct contact with the apical surface of either intercalated or principal cells. ATP biosensor responses, triggered by increased tubular flow or by bath hypotonicity, were approximately three-fold greater when positioned next to intercalated cells than next to principal cells. In addition, these responses did not occur in preparations from Cx30-deficient mice or with purinergic receptor blockade. After inducing step increases in mean arterial pressure by ligating the distal aorta followed by the mesenteric and celiac arteries, urine output increased 4.2-fold in wild-type mice compared with 2.6-fold in Cx30-deficient mice, and urinary Na(+) excretion increased 5.2-fold in wild-type mice compared with 2.8-fold in Cx30-deficient mice. Furthermore, Cx30-deficient mice developed endothelial sodium channel-dependent, salt-sensitive elevations in mean arterial pressure. Taken together, we suggest that mechanosensitive Cx30 hemichannels have an integral role in pressure natriuresis by releasing ATP into the tubular fluid, which inhibits salt and water reabsorption.

  16. Sensitivity Analysis of Dousing Spray Trip on Radioactive Release in Pressure Tube Rupture Accident with Both End Fitting Failures

    Jang, M. S.; Kang, H. S; Kim, S. R. [NESS, Daejeon (Korea, Republic of)


    We analyzed the sensitivity analysis of dousing spray trip conditions on radioactive release. In terms of conservativeness, the set 1 trip would be more appropriate in RR analysis than set 2 trip, which is the general condition of RR analysis. Radioactive releases from the containment building is related to containment air pressure, which increases by the coolant discharge from loss of coolant accident and the actuation conditions of dousing spray and so on. In LOCA analysis, the dousing spray trip conditions are set for the analysis objectives; for peak pressure (PP), for pressure signal (PS), for radioactive release (RR) and etc. In RR analysis, we would determine the dousing spray trip condition to increase radioactive release to the public for conservatism. Therefore, we carried out the sensitivity analysis of dousing spray trip condition on radioactive release from containment building using GOTHIC and SMART program for CANDU.

  17. Effects of press sizes on internal steam pressure during particleboard hot-pressing process

    Zhiyong Cai; Michael Birkeland; James M. Wescott; Jane O' Dell; Jerrold E. Winandy


    Internal steam pressure produced during the hot-pressing cycle in particleboard production is critical to the newly developed bond strength that will determine the overall performance of particleboard. The difference between the accumulation of internal steam pressure for small panels made in the laboratory and that of large commercial-sized panels makes it difficult...

  18. Effect of internal gas pressure on the shock consolidation of 304 stainless steel powders

    Elliott, N.E.; Staudhammer, K.P.


    Capsules of 304 SS powders having a pre-compacted density of 67% were shock consolidated at peak pressures of 100 GPa. Initial internal N{sub 2} gas pressures from 7 {times} 10 {sup {minus}4} Pa to 0.1 Gpa were employed. However, as the internal N{sub 2} gas pressure in the powders was increased, the quality of the compacted density decreased. While it is intuitive that high internal gas pressures in porous materials do not enhance their consolidation, a greater understanding of the consolidation process and the part entrapped (intentional or unintentional) gas plays is elucidated. 12 refs., 9 figs.

  19. Internal snapping hip syndrome: treatment by endoscopic release of the iliopsoas tendon.

    Ilizaliturri, Victor M; Villalobos, Felix E; Chaidez, Pedro A; Valero, Fernando S; Aguilera, Jose M


    The internal snapping hip syndrome is caused by slippage of the iliopsoas tendon over the iliopectineal eminence or the femoral head. Open surgical techniques have been successfully used to treat this condition. More recently, endoscopic techniques have become available to address this problem. The purpose of this study was to investigate an endoscopic technique for release of the iliopsoas tendon and its short-term results. Consecutive case series. Six patients (7 hips) with an average age of 38.5 years had an endoscopic release of the iliopsoas tendon for internal snapping hip syndrome. Hip arthroscopy was performed in every patient. Special inferior portals were used for psoas bursoscopy. The iliopsoas tendon was identified and released at the level of the lesser trochanter in all cases. Intra-articular concomitant injuries were identified and treated in 4 cases. No snapping symptoms were present in any patient after surgery nor at the last follow-up at, on average, 21 months. Significant loss of flexion strength was present after surgery but had improved by 8 weeks. In our hands, the endoscopic technique for iliopsoas tendon release was effective and reproducible and our results compare well with results of open procedures in the short term. Level IV.

  20. Internal wave-turbulence pressure above sloping sea bottoms

    van Haren, H.


    An accurate bottom pressure sensor has been moored at different sites varying from a shallow sea strait via open ocean guyots to a 1900 m deep Gulf of Mexico. All sites show more or less sloping bottom topography. Focusing on frequencies (sigma) higher than tidal, the pressure records are remarkably

  1. Viscoelastic behavior and durability of steel wire - reinforced polyethylene pipes under a high internal pressure

    Ivanov, S.; Anoshkin, A.N.; Zuyko, V.Yu


    The strength tests of steel-wire-reinforced polyethylene pipe specimens showed that, under a constant internal pressure exceeding 80% of their short-term ultimate pressure, the fracture of the specimens occurred in less than 24 hours. At pressures slightly lower than this level, some specimens did n

  2. 14C release from a Soviet-designed pressurized water reactor nuclear power plant.

    Uchrin, G; Csaba, E; Hertelendi, E; Ormai, P; Barnabas, I


    The Paks Nuclear Power Plant in Hungary runs with four pressurized water reactors, each of 440-MWe capacity. Sampling systems have been developed and used to determine the 14C of various chemical forms (14CO2, 14CO, 14CnHm) in the airborne releases. The average normalized yearly discharge rates for the time period 1988-1991 are equal to 0.77 TBq GWe-1 y-1 for hydrocarbons and 0.05 TBq GWe-1 y-1 for CO2. The contribution of 14CO was less than 0.5% of the total emission. The 14C discharge rate is estimated to be four times higher than the corresponding mean data of Western European pressurized water reactors. The calculated effective dose equivalent to individuals living in the vicinity of the power plant, due to 14C release, was 0.64 microSv in 1991 while the effective dose equivalent due to the natural 14C level was 15 microSv y-1. The long-term global impact of the 14C release in the operational period of the plant (1982-1991) was 1,270 man-Sv. The 14C excess in the environmental air has been measured since 1989 by taking biweekly samples at a distance of 1.7 km from the nuclear power plant. The long-term average of radiocarbon excess coming from the power plant was 2 mBq m-3. The local 14C deposition was followed by tree ring analysis, too. No 14C increase higher than the uncertainty of the measurement (four per thousand = 0.17 mBq m-3) was observed.

  3. Flavor release measurement by atmospheric pressure chemical ionization ion trap mass spectrometry, construction of interface and mathematical modeling of release profiles

    Haahr, Anne-Mette; Madsen, Henrik; Smedsgaard, Jørn


    An instrumental on-line retronasal flavor analysis was developed to obtain information about the release of flavor compounds in expired air from humans during eating. The volatile flavor compounds were measured by ion trap mass spectrometry with an atmospheric pressure chemical ionization source...

  4. Wind-induced internal pressure fluctuations of structure with single windward opening


    A frequency domain method for estimating wind-induced fluctuating internal pressure of structure with single windward opening is presented in this paper and wind tunnel tests were carried out to verify the theory. The nonlinear differential equation of intemal pressure dynamics and iteration algorithm were applied to calculate fluctuating internal pressure and time domain analysis was used to verify the accuracy of the proposed method. A simplified estimation method is also provided and its scope of application is clarified. The mechanism of internal pressure fluctuation is obtained by using the proposed method in the frequency domain and a new equivalent opening ratio is defined to evaluate internal pressure fluctuation. A series of low-rise building models with various openings and internal volumes were designed for wind tunnel tests with results agreeing well with analytical results. It is shown that the proposed frequency domain method based on Gaussian distribution of internal pressure fluctuations can be applied to predict the RMS internal pressure coefficient with adequate accuracy for any opening dimensions,while the simplified method can only be used for structure with single dominant opening. Helmholtz resonance is likely to occur when the equivalent opening ratio is adequately high, and controlling individual opening dimension is an effective strategy for avoiding Helmholtz resonance in engineering.

  5. CMC blade with pressurized internal cavity for erosion control

    Garcia-Crespo, Andres; Goike, Jerome Walter


    A ceramic matrix composite blade for use in a gas turbine engine having an airfoil with leading and trailing edges and pressure and suction side surfaces, a blade shank secured to the lower end of each airfoil, one or more interior fluid cavities within the airfoil having inlet flow passages at the lower end which are in fluid communication with the blade shank, one or more passageways in the blade shank corresponding to each one of the interior fluid cavities and a fluid pump (or compressor) that provides pressurized fluid (nominally cool, dry air) to each one of the interior fluid cavities in each airfoil. The fluid (e.g., air) is sufficient in pressure and volume to maintain a minimum fluid flow to each of the interior fluid cavities in the event of a breach due to foreign object damage.

  6. A New Approach To Inspect the Internal Pressure of Vacuum Switchgear

    LUO Li-wen; ZHAO Zi-yu; LI Hai-yu


    A new approach is developed to inspect the internal pressure within the vacuum switchgear by no means of magnet-exciting coil, micro-discharge threshold voltage Ud and field emission threshold voltage Ue, all of which are available in laboratory. Experimental results show that internal pressure is a function of the ratio of the micro-discharge threshold voltage to the field emission threshold voltage i.e., Ud/Ue. By this method, the internal pressure in the range of 100-10-4 Pa within vacuum chambers can be inspected without magnet-exciting coil which is required in conventional magnetron discharge method.

  7. Effects of High Pressure on Internally Self-Assembled Lipid Nanoparticles

    Kulkarni, Chandrashekhar V; Yaghmur, Anan; Steinhart, Milos;


    We present the first report on the effects of hydrostatic pressure on colloidally stabilized lipid nanoparticles enveloping inverse nonlamellar self-assemblies in their interiors. These internal self-assemblies were systematically tuned into bicontinuous cubic (Pn3m and Im3m), micellar cubic (Fd3m......), hexagonal (H2), and inverse micellar (L2) phases by regulating the lipid/oil ratio as the hydrostatic pressure was varied from atmospheric pressure to 1200 bar and back to atmospheric pressure. The effects of pressure on these lipid nanoparticles were compared with those on their equilibrium bulk...... samples, whereas the internal self-assemblies of the corresponding lipid nanoparticles displayed only pressure-modulated single phases. Interestingly, both the lattice parameters and the linear pressure expansion coefficients were larger for the self-assemblies enveloped inside the lipid nanoparticles...

  8. International Space Station (ISS) Oxygen High Pressure Storage Management

    Lewis, John R.; Dake, Jason; Cover, John; Leonard, Dan; Bohannon, Carl


    High pressure oxygen onboard the ISS provides support for Extra Vehicular Activities (EVA) and contingency metabolic support for the crew. This high pressure 02 is brought to the ISS by the Space Shuttle and is transferred using the Oxygen Recharge Compressor Assembly (ORCA). There are several drivers that must be considered in managing the available high pressure 02 on the ISS. The amount of O2 the Shuttle can fly up is driven by manifest mass limitations, launch slips, and on orbit Shuttle power requirements. The amount of 02 that is used from the ISS high pressure gas tanks (HPGT) is driven by the number of Shuttle docked and undocked EVAs, the type of EVA prebreath protocol that is used and contingency use of O2 for metabolic support. Also, the use of the ORCA must be managed to optimize its life on orbit and assure that it will be available to transfer the planned amount of O2 from the Shuttle. Management of this resource has required long range planning and coordination between Shuttle manifest on orbit plans. To further optimize the situation hardware options have been pursued.

  9. Internally Pressurized Spherical and Cylindrical Cavities in Rock Salt

    Krenk, Steen


    The paper deals with the stress distribution around cavities under pressure in an infinite, non-linear elastic material. A homogeneous stress state is assumed at infinity. For spherical and cylindrical cavities simple formulae are derived for the stress concentration, the extent of the non-linear...

  10. Dendronized Mesoporous Silica Nanoparticles Provide an Internal Endosomal Escape Mechanism for Successful Cytosolic Drug Release

    Weiss, Veronika; Torrano, Adriano A; Strobel, Claudia; Mackowiak, Stephan A; Gatzenmeier, Tim; Hilger, Ingrid; Braeuchle, Christoph; Bein, Thomas


    Mesoporous silica nanoparticles (MSNs) attract increasing interest in the field of gene and drug delivery due to their versatile features as a multifunctional drug delivery platform. Here, we describe poly(amidoamine) (PAMAM) dendron-functionalized MSNs that fulfill key prerequisites for a controllable intracellular drug release. In addition to high loading capacity, they offer 1) low cytotoxicity, showing no impact on the metabolism of endothelial cells, 2) specific cancer cell targeting due to receptor-mediated cell uptake, 3) a redox-driven cleavage of disulfide bridges allowing for stimuli-responsive cargo release, and most importantly, 4) a specific internal trigger based on the high buffering capacity of PAMAM dendrons to provide endosomal escape.

  11. Evaluation of CANDU NPP containment structure subjected to aging and internal pressure increase

    Huang, Xu [Department of Civil Engineering, University of Toronto, Toronto M5S 1A4 (Canada); Kwon, Oh-Sung, E-mail: [Department of Civil Engineering, University of Toronto, Toronto M5S 1A4 (Canada); Bentz, Evan [Department of Civil Engineering, University of Toronto, Toronto M5S 1A4 (Canada); Tcherner, Julia [Candu Energy Inc. a member of SNC-Lavalin Group, Mississauga L5K 1B1 (Canada)


    Highlights: • The aging effects on the performance of a nuclear containment structure is evaluated. • A numerical model of the structure is subjected to increasing internal pressure. • No through-thickness cracks are predicted under the design level internal pressure. • The structure is predicted to be ductile up to large internal pressure levels. - Abstract: The objective of this study is to investigate the long-term performance of a typical CANDU® containment structure. A three-dimensional nonlinear finite element model was built to realistically evaluate the performance of the structure under service load as well as a hypothetical beyond-design level internal pressure. Consideration is given to the time-dependent effects, such as shrinkage, creep, and relaxation of prestressing tendons, over a 60-year timeframe. In addition, the sensitivity of the response of the containment structure against support condition, internal temperature profile and temporary construction openings was also investigated. The accuracy of the numerical model was validated against structural measurements made during a routine leak rate test. The analysis results show that the containment structure would develop a ductile mechanism if the internal pressure significantly exceeded the design pressure. The pressure-deformation relationship of the structure is sensitive to the considered time-dependent parameters.

  12. Blood pressure variability in relation to outcome in the International Database of Ambulatory blood pressure in relation to Cardiovascular Outcome

    Stolarz-Skrzypek, Katarzyna; Thijs, Lutgarde; Richart, Tom


    Ambulatory blood pressure (BP) monitoring provides information not only on the BP level but also on the diurnal changes in BP. In the present review, we summarized the main findings of the International Database on Ambulatory BP in relation to Cardiovascular Outcome (IDACO) with regard to risk...

  13. Effect of advanced blood pressure control with nifedipine delayed-release tablets on the blood pressure in patients underwent nasal endoscope surgery

    Qing-Hua Xiao; Li Yang; Rong-Ping Chen; Wei-Dong Qiu


    Objective:To explore the effect of advanced blood pressure control with nifedipine delayed-release tablets on the blood pressure in patients underwent nasal endoscope surgery and its feasibility.Methods:A total of 80 patients who were admitted in ENT department from June, 2012 to June, 2015 for nasal endoscope surgery were included in the study and randomized into the observation group and the control group with 40 cases in each group. The patients in the observation group were given nifedipine delayed-release tablets for advanced blood pressure control before operation, and were given routine blood pressure control during operation; while the patients in the control group were only given blood pressure control during operation. The changes of blood pressure, mean central arterial pressure, and heart rate before anesthesia (T0), after intubation (T1), during operation (T2), extubation when waking (T3), 30 min after extubation (T4), and 3 h after back to wards (T5) in the two groups were compared. The intraoperative situation and the surgical field quality in the two groups were compared.Results: SBP, DBP, and MAP levels at T1-5 in the two groups were significantly lower than those at T0. SBP, DBP, and MAP levels at T2 were significantly lower than those at other timing points, and were gradually recovered after operation, but were significantly lower than those at T0. The effect taking time of blood pressure reducing, intraoperative nitroglycerin dosage, and postoperative wound surface exudation amount in the observation group were significantly less than those in the control group. The surgical field quality scores in the observation group were significantly superior to those in the control group.Conclusions:Advanced blood pressure control with nifedipine delayed-release tablets can stabilize the blood pressure during the perioperative period in patients underwent nasal endoscope surgery, and enhance the surgical field qualities.

  14. Correlation between balloon release pressure and no-reflow in patients with acute myocardial infarction undergoing direct percutaneous coronary intervention

    Wang Yanfei; Yao Min; Liu Haibo; Yang Yuejin; Xie Junmin; Jia Xinwei; Pan Huanjun


    Background Balloon release pressure may increase the incidence of no reflow after direct percutaneous coronary intervention (PCI).This randomized controlled study was designed to analyze the correlation between balloon release pressure and no-reflow in patients with acute myocardial infarction (AMI) undergoing direct PCI.Methods There were 156 AMI patients who underwent PCI from January 1,2010 to December 31,2012,and were divided into two groups according to the stent inflation pressure:a conventional pressure group and a high pressure group.After PCI,angiography was conducted to assess the thrombolysis in myocardial infarction (TIMI) grade with related artery.Examinations were undertaken on all patients before and after the operation including cardiac enzymes,total cholesterol,low-density lipoprotein,blood glucose,homocysteine,β-thromboglobulin (β-TG),Hamilton depression scale (HAMD) and self-rating anxiety scale (SAS).After interventional therapy,the afore-mentioned parameters in both the conventional pressure group and high pressure group were again analyzed.Results The results showed that CK-MB,HAMD,SAS were significantly different (P <0.05) in all patients after PCI,especially the CK-MB in the high pressure group ((25.7±7.6) U/L vs.(76.7±11.8) U/L).CK-MB,HAMD,SAS,and β-TG were comparative before PCI but they were significantly changed (P <0.05) after intervention.No-reflow phenomenon occurred in 13 patients in the high pressure group,which was significantly higher than in the conventional pressure group (17.11% vs.6.25%,P<0.05).Conclusion In stent implantation,using a pressure less than 1823.4 kPa balloon to release pressure may be the better choice to reduce the occurrence of no-reflow following direct PCI.

  15. Evaluation of Tritium Content and Release from Pressurized Water Reactor Fuel Cladding

    Robinson, Sharon M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chattin, Marc Rhea [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Giaquinto, Joseph [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jubin, Robert Thomas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)


    will behave during processing, scoping tests are being performed to determine the tritium content in the cladding pre- and post-tritium pretreatment. Samples of Surry-2 and H.B. Robinson pressurized water reactor cladding were heated to 1100–1200°C to oxidize the zirconium and release all of the tritium in the cladding sample. Cladding samples were also heated within the temperature range of 480–600ºC expected for standard air tritium pretreatment systems, and to a slightly higher temperature (700ºC) to determine the impact of tritium pretreatment on tritium release from the cladding. The tritium content of the Surry-2 and H.B. Robinson cladding was measured to be ~234 and ~500 µCi/g, respectively. Heating the Surry-2 cladding at 500°C for 24 h removed ~0.2% of the tritium from the cladding, and heating at 700°C for 24 h removed ~9%. Heating the H.B. Robinson cladding at 700°C for 24 h removed ~11% of the tritium. When samples of the Surry-2 and H.B. Robinson claddings were heated at 700°C for 96 h, essentially all of the tritium in the cladding was removed. However, only ~3% of the tritium was removed when a sample of Surry-2 cladding was heated at 600°C for 96 h. These data indicate that the amount of tritium released from tritium pretreatment systems will be dependent on both the operating temperature and length of time in the system. Under certain conditions, a significant fraction of the tritium could remain bound in the cladding and would need to be considered in operations involving cladding recycle.

  16. Smart bridge and building materials in which cyclic motion is controlled by internally released adhesives

    Dry, Carolyn M.


    The object of this research is to assess the feasibility of using the concept of self-healing concretes for structural highway elements such as bridges, and roadway pavements. Our research has concentrated on the material behavior of self-healing cements which internally release adhesive when crack damage occurs. The focus of this research is on the use of self- healing concretes in structural highway members, such as bridges, that may be damaged by dynamic events such as earthquakes, impacts. A following study will investigate the influence of different types of adhesives and release mechanisms in the concrete elements under several load histories, for self-healing of the structural element. In the experimental program, the first set of specimens used typical elements, such as frames containing adhesive loaded fibers. The results were positive. From there we next go on to joints containing several types of adhesives and release mechanisms. These are tested on a small shake table in which actuators, load sensors, and a deflection monitor are mounted on a base. The adhesives have different set times, strength of bond with the matrix, and elastic moduli. The specimens are tested for the effect of adhesive type on deflection, stiffness, and damping of the members.

  17. Optimized loading and sustained release of hydrophilic proteins from internally nanostructured particles.

    Chemelli, Angela; Maurer, Manuela; Geier, Roman; Glatter, Otto


    In this study, we demonstrate that emulsified microemulsions and micellar cubosomes are suitable as sustained delivery vehicles for water-soluble proteins. Through structural modifications, the loading efficiency of two model proteins, namely bovine serum albumin (BSA) and cytochrome c could be remarkably increased. A procedure for preparing these particles loaded with optimized amounts of sensitive substances is presented. Loading and dispersion at low temperatures is performed in two successive steps. First, a water-in-oil microemulsion is loaded with the proteins. Subsequently, this phase is dispersed in water resulting in particles with microemulsion and micellar cubic internal structure and a size of approximately 620 nm. This two-step method ensures optimal loading of the particles with the proteins. These nanostructured particles are able to sustain the release of the water-soluble BSA and cytochrome c. Within one day, less than 10% of BSA and 15% of cytochrome c are released. The release rate of cytochrome c is influenced by the nanostructure of the particles.

  18. Registers of pressure ulcers in an international context

    Andrea Pokorná


    Full Text Available Aim: The aim of the following review was to search for existing registers of pressure ulcer (PU incidence operating and collecting data on national level. Design: Type of study - review. Methods: Articles focusing on the subject of national PU registers were searched for by means of a systematic trawl through various databases using relevant terms. The search was limited to articles in English issued between 2010 and 2015 in the electronic databases SCOPUS and Nursing OVID. Articles focused on local datasets or registry as a part of local electronic health records were not included as well as studies which do not describe the dataset or the usability of data collection. Results: In total, six papers were found fulfilling the established criteria. Conclusion: According to information available from the literature review, it was recognised that only one register of PUs currently exists at the national level - the Registry of Ulcer Treatment (RUT in Sweden. It can be assumed that registers exist in other countries, but that the information is not available on electronic databases. After a detailed inspection of the articles, it appears the information derived from the studies could provide a useful picture of the data that should be collected, and at what time during the treatment period (initial and final assessment of the patients and local symptomatology of the wound/pressure ulcer it should be collected.

  19. 77 FR 23513 - Updated Aging Management Criteria for Reactor Vessel Internal Components of Pressurized Water...


    ... COMMISSION Updated Aging Management Criteria for Reactor Vessel Internal Components of Pressurized Water... Management Criteria for PWR Reactor Vessel Internal Components.'' The original notice provided the ADAMS... published a notice requesting public comments on draft LR-ISG-2011-04, ``Updated Aging Management...

  20. Internal wave pressure, velocity, and energy flux from density perturbations

    Allshouse, Michael R; Morrison, Philip J; Swinney, Harry L


    Determination of energy transport is crucial for understanding the energy budget and fluid circulation in density varying fluids such as the ocean and the atmosphere. However, it is rarely possible to determine the energy flux field $\\mathbf{J} = p \\mathbf{u}$, which requires simultaneous measurements of the pressure and velocity perturbation fields, $p$ and $\\mathbf{u}$. We present a method for obtaining the instantaneous $\\mathbf{J}(x,z,t)$ from density perturbations alone: a Green's function-based calculation yields $p$, and $\\mathbf{u}$ is obtained by integrating the continuity equation and the incompressibility condition. We validate our method with results from Navier-Stokes simulations: the Green's function method is applied to the density perturbation field from the simulations, and the result for $\\mathbf{J}$ is found to agree typically to within $1\\%$ with $\\mathbf{J}$ computed directly using $p$ and $ \\mathbf{u}$ from the Navier-Stokes simulation. We also apply the Green's function method to densit...

  1. Research and development on transonic compressor of high pressure ratio turbocharger for vehicle internal combustion engines


    The pressure ratio required for a turbocharger centrifugal compressor increases with internal combustion engine power density. High pressure ratio causes a transonic flow field at the impeller inducer. Transonic flow narrows the stable flow range and de-teriorates stage efficiency. In this work, an advanced high pressure ratio transonic compressor was designed. The experimental results show that the maximum pressure ratio of this turbocharger is about 4.2, the maximum efficiency is above 80% and the stable flow range at the designed rotating speed is up to 34%. A turbocharger with this transonic compressor has been applied to some vehicle research actually, and improved power density by 40%.

  2. A method for simulating the release of natural gas from the rupture of high-pressure pipelines in any terrain.

    Deng, Yajun; Hu, Hongbing; Yu, Bo; Sun, Dongliang; Hou, Lei; Liang, Yongtu


    The rupture of a high-pressure natural gas pipeline can pose a serious threat to human life and environment. In this research, a method has been proposed to simulate the release of natural gas from the rupture of high-pressure pipelines in any terrain. The process of gas releases from the rupture of a high-pressure pipeline is divided into three stages, namely the discharge, jet, and dispersion stages. Firstly, a discharge model is established to calculate the release rate of the orifice. Secondly, an improved jet model is proposed to obtain the parameters of the pseudo source. Thirdly, a fast-modeling method applicable to any terrain is introduced. Finally, based upon these three steps, a dispersion model, which can take any terrain into account, is established. Then, the dispersion scenarios of released gas in four different terrains are studied. Moreover, the effects of pipeline pressure, pipeline diameter, wind speed and concentration of hydrogen sulfide on the dispersion scenario in real terrain are systematically analyzed. The results provide significant guidance for risk assessment and contingency planning of a ruptured natural gas pipeline. Copyright © 2017. Published by Elsevier B.V.

  3. From Spin Noise to Systematics: Stochastic Processes in the First International Pulsar Timing Array Data Release

    Lentati, L; Coles, W A; Verbiest, J P W; van Haasteren, R; Ellis, J A; Caballero, R N; Manchester, R N; Arzoumanian, Z; Babak, S; Bassa, C G; Bhat, N D R; Brem, P; Burgay, M; Burke-Spolaor, S; Champion, D; Chatterjee, S; Cognard, I; Cordes, J M; Dai, S; Demorest, P; Desvignes, G; Dolch, T; Ferdman, R D; Fonseca, E; Gair, J R; Gonzalez, M E; Graikou, E; Guillemot, L; Hessels, J W T; Hobbs, G; Janssen, G H; Jones, G; Karuppusamy, R; Keith, M; Kerr, M; Kramer, M; Lam, M T; Lasky, P D; Lassus, A; Lazarus, P; Lazio, T J W; Lee, K J; Levin, L; Liu, K; Lynch, R S; Madison, D R; McKee, J; McLaughlin, M; McWilliams, S T; Mingarelli, C M F; Nice, D J; Osłowski, S; Pennucci, T T; Perera, B B P; Perrodin, D; Petiteau, A; Possenti, A; Ransom, S M; Reardon, D; Rosado, P A; Sanidas, S A; Sesana, A; Shaifullah, G; Siemens, X; Smits, R; Stairs, I; Stappers, B; Stinebring, D R; Stovall, K; Swiggum, J; Taylor, S R; Theureau, G; Tiburzi, C; Toomey, L; Vallisneri, M; van Straten, W; Vecchio, A; Wang, J -B; Wang, Y; You, X P; Zhu, W W; Zhu, X -J


    We analyse the stochastic properties of the 49 pulsars that comprise the first International Pulsar Timing Array (IPTA) data release. We use Bayesian methodology, performing model selection to determine the optimal description of the stochastic signals present in each pulsar. In addition to spin-noise and dispersion-measure (DM) variations, these models can include timing noise unique to a single observing system, or frequency band. We show the improved radio-frequency coverage and presence of overlapping data from different observing systems in the IPTA data set enables us to separate both system and band-dependent effects with much greater efficacy than in the individual PTA data sets. For example, we show that PSR J1643$-$1224 has, in addition to DM variations, significant band-dependent noise that is coherent between PTAs which we interpret as coming from time-variable scattering or refraction in the ionised interstellar medium. Failing to model these different contributions appropriately can dramatically...

  4. Improved wound healing in pressure-induced decubitus ulcer with controlled release of basic fibroblast growth factor

    Jiang Wei [Department of Respiratory Diseases, Tangdu Hospital, Fourth Military Medical University, Xi' an 710038 (China); Wang Hailun [Department of Dermatology, Tangdu Hospital, Fourth Military Medical University, Xi' an 710038 (China); Jin Faguang [Department of Respiratory Diseases, Tangdu Hospital, Fourth Military Medical University, Xi' an 710038 (China)], E-mail:; Yu Chunyan [Department of Dermatology, Tangdu Hospital, Fourth Military Medical University, Xi' an 710038 (China); Chu Dongling [Department of Respiratory Diseases, Tangdu Hospital, Fourth Military Medical University, Xi' an 710038 (China); Wang Lin [Department of Internal Medicine, 316 Hospital of PLA, Beijing 100093 (China); Lu Xian [93942 Unit Hospital of PLA, Xianyang 710012 (China)


    The purpose was to evaluate the efficacy of the wound dressing containing basic fibroblast growth factor (bFGF)-loaded microspheres on promoting healing in pressure-induced decubitus ulcer. In this study, the pressure-induced ulcer in swine was used as a model to demonstrate the hypothesis that controlled release of bFGF has the potential to provide optimal healing milieu for chronic wounds in the repair process. Average size of the microspheres was 14.36 {+-} 3.56 {mu}m and the network gelatin sponges were characterized with an average pore size of 80-160 {mu}m. Both the in vitro release efficiency and the protein bioactivity revealed that bFGF was released from the microspheres in a controlled manner and it was biologically active as assessed by its ability to induce the proliferation of fibroblasts. Pressure-induced ulcer was created at 500 g/cm{sup 2} pressure loaded on swine dorsal skin 12 h daily for 2 consecutive days. After removal of the pressure load, the gelatin sponge containing bFGF gelatin microspheres or bFGF in solution was implanted into the wound. Swine were sacrificed at 7, 14, and 21 days after implantation, and a full-thickness biopsy was taken and stained for histological analysis. It was observed that controlled release of bFGF provided an accelerated recovery in the wound areas. Histological investigations showed that the dressings were biocompatible and had capability of proliferating fibroblasts and inducing neovascularisation. The present study implied the clinical potential of gelatin sponge with bFGF microspheres to promote the healing in pressure-induced decubitus ulcer.

  5. Wind-induced internal pressure response for structure with single windward opening and background leakage

    Shi-ce YU; Wen-juan LOU; Bing-nan SUN


    Theoretical analysis and wind tunnel tests were carried out to study wind-induced internal pressure response for the structure with single windward opening and background leakage. Its governing differential equation was derived by the Bernoulli equation in an unsteady-isentropic form. Numerical examples were provided to study the additive damping caused by background leakage in laminar and turbulent flow, and the influence of background leakage on fluctuating internal pressure response was quantized. A series of models for low-rise building with various opening ratios and background leakage were designed and wind tunnel tests were conducted. It is shown that the fluctuating internal pressure reduces when the background leakage are considered and that the effect of background leakage can be predicted accurately by the governing differential equation deduced in this paper.

  6. Gas Loss by Ram Pressure Stripping and Internal Feedback From Low Mass Milky Way Satellites

    Emerick, Andrew; Grcevich, Jana; Gatto, Andrea


    The evolution of dwarf satellites of the Milky Way is affected by the combination of ram pressure and tidal stripping, and internal feedback from massive stars. We investigate gas loss processes in the smallest satellites of the Milky Way using three-dimensional, high resolution, idealized wind tunnel simulations, accounting for gas loss through both ram pressure stripping and expulsion by supernova feedback. Using initial conditions appropriate for a dwarf galaxy like Leo T, we investigate whether or not environmental gas stripping and internal feedback can quench these low mass galaxies on the expected timescales, shorter than 2 Gyr. We find that supernova feedback contributes negligibly to the stripping rate for these low star formation rate galaxies. However, we also find that ram pressure stripping is less efficient than expected in the stripping scenarios we consider. Our work suggests that, although ram pressure stripping can eventually completely strip these galaxies, other physics is likely at play t...

  7. A stochastic model for the indicated pressure process and the dynamics of the internal combustion engine

    Rizzoni, G. (Michigan Univ., Ann Arbor, MI (USA). Dept. of Electrical Engineering and Computer Science)


    In-cylinder gas pressure has long been recognized as a fundamental measure of performance in the internal combustion engine. Among the issues that have been the subject of research in recent years is the study of the effects cyclic combustion variability has on the cycle-to-cycle and cylinder-to-cylinder fluctuations in combustion pressures. Some of the research problems pertaining to cyclic combustion variability are to reformulate from a perspective markedly different from the fluid dynamic and thermodynamic models which traditionally characterize this research: a system viewpoint is embraced to construct a stochastic model for the indicated pressure process and the dynamics of the internal combustion engine. First a deterministic model for the dynamics of the engine is described; then a stochastic model is proposed for the cylinder pressure process. The deterministic model and the stochastic representation are then tied together in a Kalman filter model. Experimental results are discussed to validate the models.

  8. Internalization and recycling of receptor-bound gonadotropin-releasing hormone agonist in pituitary gonadotropes

    Schvartz, I.; Hazum, E.


    The fate of cell surface gonadotropin-releasing hormone (GnRH) receptors on pituitary cells was studied utilizing lysosomotropic agents and monensin. Labeling of pituitary cells with a photoreactive GnRH derivative, (azidobenzoyl-D-Lys6)GnRH, revealed a specific band of Mr = 60,000. When photoaffinity-labeled cells were exposed to trypsin immediately after completion of the binding, the radioactivity incorporated into the Mr = 60,000 band decreased, with a concomitant appearance of a proteolytic fragment (Mr = 45,000). This fragment reflects cell surface receptors. Following GnRH binding, the hormone-receptor complexes underwent internalization, partial degradation, and recycling. The process of hormone-receptor complex degradation was substantially prevented by lysosomotropic agents, such as chloroquine and methylamine, or the proton ionophore, monensin. Chloroquine and monensin, however, did not affect receptor recycling, since the tryptic fragment of Mr = 45,000 was evident after treatment with these agents. This suggests that recycling of GnRH receptors in gonadotropes occurs whether or not the internal environment is acidic. Based on these findings, we propose a model describing the intracellular pathway of GnRH receptors.

  9. The release of dipicolinic acid--the rate-limiting step of Bacillus endospore inactivation during the high pressure thermal sterilization process.

    Reineke, Kai; Schlumbach, Karl; Baier, Daniel; Mathys, Alexander; Knorr, Dietrich


    High pressure combined with elevated temperatures can produce low acid, commercially sterile and shelf-stable foods. Depending on the temperature and pressure levels applied, bacterial endospores pass through different pathways, which can lead to a pressure-induced germination or inactivation. Regardless of the pathway, Bacillus endospores first release pyridine-2,6-dicarboxylic acid (DPA), which contributes to the low amount of free water in the spore core and is consequently responsible for the spore's high resistance against wet and dry heat. This is therefore the rate-limiting step in the high pressure sterilization process. To evaluate the impact of a broad pressure, temperature and time domain on the DPA release, Bacillus subtilis spores were pressure treated between 0.1 and 900 MPa at between 30 and 80 °C under isothermal isobaric conditions during dwell time. DPA quantification was assessed using HPLC, and samples were taken both immediately and 2 h after the pressure treatment. To obtain a release kinetic for some pressure-temperature conditions, samples were collected between 1s and 60 min after decompression. A multiresponse kinetic model was then used to derive a model covering all kinetic data. The isorate lines modeled for the DPA release in the chosen pressure-temperature landscape enabled the determination of three distinct zones. (I) For pressures 50 °C, a 90% DPA release was achievable in less than 5 min and no difference in the amount of DPA was found immediately 2 h after pressurization. This may indicate irreversible damage to the inner spore membrane or membrane proteins. (II) Above 600 MPa the synergism between pressure and temperature diminished, and the treatment temperature alone dominated DPA release. (III) Pressures pressure-induced physiological like germination with cortex degradation, which continues after pressure release. Furthermore, at 600 MPa and 40 °C, a linear relationship was found for the DPA release rate constants ln

  10. Static internal pressure capacity of Hanford Single-Shell Waste Tanks

    Julyk, L.J.


    Underground single-shell waste storage tanks located at the Hanford Site in Richland, Washington, generate gaseous mixtures that could be ignited, challenging the structural integrity of the tanks. The structural capacity of the single-shell tanks to internal pressure is estimated through nonlinear finite-element structural analyses of the reinforced concrete tank. To determine their internal pressure capacity, designs for both the million-gallon and the half-million-gallon tank are evaluated on the basis of gross structural instability.

  11. Mechanical Response of Steel Wire Wound Reinforced Rubber Flexible Pipe under Internal Pressure

    GU Fan; HUANG Cheng-kui; ZHOU Jing; LI Lin-pu


    Steel wire wound reinforced flexible pipe in this study mainly consists of multiple anisotropic steel wire wound reinforcement layers and multiple isotropic rubber layers. Based on 3D anisotropic elastic theory, the analytic solutions of stresses and elastic deformations of steel wire wound reinforced rubber flexible pipe under internal pressure are presented. As the adjacent reinforcement layers with wound angle have different radii, the single reinforcement layer shows the effect of tensile-shear coupling. Moreover, the static loading test results of steel wire wound reinforced rubber flexible pipe under internal pressure are basically coincided with the calculated values by present method.

  12. Analysis of Pressure Rise in a Closed Container Due to Internal Arcing

    Peng Li


    Full Text Available When an arc fault occurs in a medium-voltage (MV metal enclosed switchgear, the arc heats the filling gas, resulting in a pressure rise, which may seriously damage the switchgear, the building it is contained in, or even endanger maintenance personnel. A pressure rise calculation method based on computational fluid dynamics (CFD has been put forward in this paper. The pressure rise was calculated and the arc tests between the copper electrodes were performed in the container under different gap lengths by the current source. The results show that the calculated pressure rise agrees well with the measurement, and the relative error of the average pressure rise is about 2%. Arc volume has less effect on the pressure distribution in the container. Arc voltage Root-Mean-Square (RMS has significant randomness with the change of arc current, and increases with the increase of gap length. The average arc voltage gradients measure at about 26, 20 and 16 V/cm when the gap lengths are 5, 10 and 15 cm, respectively. The proportion (thermal transfer coefficient kp of the arc energy leading to the pressure rise in the container is about 44.9%. The pressure is symmetrically distributed in the container before the pressure wave reaches the walls and the process of the energy release is similar to an explosion. The maximum overpressure in the corner is increased under the reflection and superimposition effects of the pressure wave, but the pressure waves will be of no importance any longer than a few milliseconds in the closed container.

  13. Hydrostatic pressure and shear stress affect endothelin-1 and nitric oxide release by endothelial cells in bioreactors.

    Vozzi, Federico; Bianchi, Francesca; Ahluwalia, Arti; Domenici, Claudio


    Abundant experimental evidence demonstrates that endothelial cells are sensitive to flow; however, the effect of fluid pressure or pressure gradients that are used to drive viscous flow is not well understood. There are two principal physical forces exerted on the blood vessel wall by the passage of intra-luminal blood: pressure and shear. To analyze the effects of pressure and shear independently, these two stresses were applied to cultured cells in two different types of bioreactors: a pressure-controlled bioreactor and a laminar flow bioreactor, in which controlled levels of pressure or shear stress, respectively, can be generated. Using these bioreactor systems, endothelin-1 (ET-1) and nitric oxide (NO) release from human umbilical vein endothelial cells were measured under various shear stress and pressure conditions. Compared to the controls, a decrease of ET-1 production by the cells cultured in both bioreactors was observed, whereas NO synthesis was up-regulated in cells under shear stress, but was not modulated by hydrostatic pressure. These results show that the two hemodynamic forces acting on blood vessels affect endothelial cell function in different ways, and that both should be considered when planning in vitro experiments in the presence of flow. Understanding the individual and synergic effects of the two forces could provide important insights into physiological and pathological processes involved in vascular remodeling and adaptation.

  14. Treatment of clinical endometritis in dairy cows by previously used controlled internal drug release devices.

    Eslami, Mohsen; Bolourchi, Mahmoud; Seifi, Hesam A; Asadi, Farzad; Akbari, Rahmat


    Postpartum endometritis is considered as one of the diseases that lead to a potential profit reduction in dairy cows. The aims of the present study were to promote follicle growth by a previously used controlled internal drug release (CIDR) device and to evaluate its effect on the likelihood of recovery and the reproductive performance of clinical endometritis (CE) cows. Endometritis was diagnosed using ultrasonographic examination at 31 ± 3 (Day 0 of the experiment) days in milk, and CE cows were included in one of the three experimental groups according to the presence of a CL on their ovaries. Cows without CL on their ovaries received a reused CIDR device, which was previously used for 14 days (CIDR-14, n = 108), or PGF2α (PG-1, n = 112) on Day 0. In the third group, those with CL on their ovaries received PGF2α (PG-2, n = 107) at the same time. Ovarian structures, serum estradiol and progesterone concentrations were measured on Days 0, 7, and 14. Controlled internal drug release devices were removed, and response to treatment was evaluated in all treated cows on Day 14. Diameters of ovarian follicles were 11.61 ± 0.50, 12.46 ± 0.25, and 18.36 ± 0.60 mm on Day 7 and 11.63 ± 0.58, 14.35 ± 0.40, and 21.96 ± 0.77 mm on Day 14 in PG-1, PG-2, and CIDR-14 cows, respectively (P estradiol concentrations were higher in CIDR-14 cows (141.17 ± 1.04 pg/mL) than in PG-1 (116.85 ± 1.05 pg/mL) and PG-2 (119.10 ± 1.05 pg/mL) cows on Day 7 (P 0.05). The cumulative pregnancy risk was lower in PG-1 (77.67%) cows than in CIDR-14 (87.07%) and PG-2 (87.85%) cows (P = 0.02). In conclusion, reused CIDR would be contributed to the treatment of CE by promotion of follicle growth and induction of sustainable sources of endogenic estrogen secreted by the dominant follicle.

  15. Bottom-pressure observations of deep-sea internal hydrostatic and non-hydrostatic motions

    van Haren, H.


    In the ocean, sloping bottom topography is important for the generation and dissipation of internal waves. Here, the transition of such waves to turbulence is demonstrated using an accurate bottom-pressure sensor that was moored with an acoustic Doppler current profiler and high-resolution thermisto

  16. 77 FR 16270 - Updated Aging Management Criteria for Reactor Vessel Internal Components of Pressurized Water...


    ... COMMISSION Updated Aging Management Criteria for Reactor Vessel Internal Components of Pressurized Water... license renewal interim staff guidance (LR-ISG), LR-ISG-2011-04, ``Updated Aging Management Criteria for... Aging Lessons Learned (GALL) Report for the aging management of stainless steel structures...

  17. Effect of Backpacking and Internal Pressurization on Stresses Transmitted to Buried Cylinders.

    Various aspects of the behavior of buried cylinders associated with backpacking , internal pressurization, and slippage at the interface are...considered. Parametric curves are presented for horizontally and vertically buried cylinders with and without backpacking . Four configurations of statically...loaded, horizontally buried cylinders were considered: no backpacking , rectangular backpacking placed above the cylinder, backpacking placed around

  18. Quantification of surface tension and internal pressure generated by single mitotic cells.

    Fischer-Friedrich, Elisabeth; Hyman, Anthony A; Jülicher, Frank; Müller, Daniel J; Helenius, Jonne


    During mitosis, adherent cells round up, by increasing the tension of the contractile actomyosin cortex while increasing the internal hydrostatic pressure. In the simple scenario of a liquid cell interior, the surface tension is related to the local curvature and the hydrostatic pressure difference by Laplace's law. However, verification of this scenario for cells requires accurate measurements of cell shape. Here, we use wedged micro-cantilevers to uniaxially confine single cells and determine confinement forces while concurrently determining cell shape using confocal microscopy. We fit experimentally measured confined cell shapes to shapes obeying Laplace's law with uniform surface tension and find quantitative agreement. Geometrical parameters derived from fitting the cell shape, and the measured force were used to calculate hydrostatic pressure excess and surface tension of cells. We find that HeLa cells increase their internal hydrostatic pressure excess and surface tension from ≈ 40 Pa and 0.2 mNm(-1) during interphase to ≈ 400 Pa and 1.6 mNm(-1) during metaphase. The method introduced provides a means to determine internal pressure excess and surface tension of rounded cells accurately and with minimal cellular perturbation, and should be applicable to characterize the mechanical properties of various cellular systems.

  19. Uncertainty analysis of spent nuclear fuel isotopics and rod internal pressure

    Bratton, Ryan N.

    The bias and uncertainty in fuel isotopic calculations for a well-defined radio- chemical assay benchmark are investigated with Sampler, the new sampling-based uncertainty quantification tool in the SCALE code system. Isotopic predictions are compared to measurements of fuel rod MKP109 of assembly D047 from the Calvert Cliffs Unit 1 core at three axial locations, representing a range of discharged fuel burnups. A methodology is developed which quantifies the significance of input parameter uncertainties and modeling decisions on isotopic prediction by compar- ing to isotopic measurement uncertainties. The SCALE Sampler model of the D047 assembly incorporates input parameter uncertainties for key input data such as multigroup cross sections, decay constants, fission product yields, the cladding thickness, and the power history for fuel rod MKP109. The effects of each set of input parameter uncertainty on the uncertainty of isotopic predictions have been quantified. In this work, isotopic prediction biases are identified and an investiga- tion into their sources is proposed; namely, biases have been identified for certain plutonium, europium, and gadolinium isotopes for all three axial locations. More- over, isotopic prediction uncertainty resulting from only nuclear data is found to be greatest for Eu-154, Gd-154, and Gd-160. The discharge rod internal pressure (RIP) and cladding hoop stress (CHS) distributions are quantified for Watts Bar Nuclear Unit 1 (WBN1) fuel rods by modeling core cycle design data, operation data (including modeling significant trips and downpowers), and as-built fuel enrichments and densities of each fuel rod in FRAPCON-3.5. A methodology is developed which tracks inter-cycle as- sembly movements and assembly batch fabrication information to build individual FRAPCON inputs for each considered WBN1 fuel rod. An alternate model for the amount of helium released from zirconium diboride (ZrB2) integral fuel burn- able absorber (IFBA) layers is

  20. Towards international consensus on patient harm: perspectives on pressure injury policy.

    Jackson, Debra; Hutchinson, Marie; Barnason, Susan; Li, William; Mannix, Judy; Neville, Stephen; Piper, Donella; Power, Tamara; Smith, Graeme D; Usher, Kim


    To analyse influential policies that inform practice related to pressure injury management in Australia, England, Hong Kong, New Zealand, Scotland and the United States of America. Pressure injuries are associated with significant harm to patients, and carry economic consequences for the health sector. Internationally, preventing and managing pressure injuries is a key nursing activity and quality indicator. Comparative review and synthesis of pressure injury policies that inform practice. The predominant focus of policy is on patient risk assessment, compliance with documentation and pressure relief. Financial penalty for institutions is emerging as a strategy where pressure injuries occur. Comparisons of prevalence rates are hampered by the lack of consensus on data collection and reporting. To date there has been little evaluation of policy implementation and implemented policy strategies, associated guidelines remain founded upon expert opinion and low-level evidence. The pressure injury policy agenda has fostered a discourse of attention to incidents, compliance and penalty (sanctions). Prevention and intervention strategies are informed by technical and biomedical interpretations of patient risk and harm, with little attention given to the nature or design of nursing work. Considerable challenges remain if this policy agenda is successfully to eliminate pressure injury as a source of patient harm. © 2016 John Wiley & Sons Ltd.

  1. [Suspension-sedimentation of sediment and release amount of internal load in Lake Taihu affected by wind].

    Pang, Yong; Yan, Run-run; Yu, Zhong-bo; Li, Yi-ping; Li, Rui-ling


    The water quality in Meiliang Bay of the Taihu Lake was totally tested five times in the four seasons. The suspension samples were obtained by using a sediment trap. The sediment settling flux and resuspended flux were calculated according to the observation data by using Gansith formula, and the relationships between these fluxes and wind speeds were established. Seven experiments were conducted in Laboratory for hydrostatic settling behavior of suspended matter affected by different wind speeds in Lake Taihu. The hydrostatic settling fluxes of suspended matter were calculated and the relationships between the fluxes and suspended matter concentrations were established. Base on these works, the suspension-sedimentation process was decomposed and generalized according to the critical wind speed of 3.7 m/s. Daily sediment resuspended amount and settling amount of the year 2005 was calculated and annual average release amount of internal load in Lake Taihu was estimated using the wind data of nearly 10 years. The results indicate that daily release amount of internal load in Lake Taihu significantly influenced by wind and have the same trend of change with wind, while the release amount of different nutrients in the same condition are different. The Lake Taihu has an annual average release amount of internal load with COD 49,600 t, TN 7773.0 t and TP 275.5 t, of which summer has the markedly highest release amount than other seasons.

  2. Intelligent Detector of Internal Combustion Engine Cylinder Pressure and Sensitivity Temperature Coefficient Compensation

    Beirong Zheng


    Full Text Available The detecting device based on mechanical mechanism is far from the measurement of internal combustion engine cylinder explosion and compression pressure. This pressure detection is under the environment of pulsed gas (over 500 times per one minute and mechanical impactive vibration. Piezoresistive detection with silicon on insulator (SOI strain gauges to pressure seems to be a good solution to meet such special applications. In this work, separation by implanted oxygen (SIMOX wafer was used to fabricate the high temperature pressure sensor chip. For high accuracy and wide temperature range application, this paper also presents a novel pressure sensitivity temperature coefficient (TCS compensation method, using integrated constant current network. A quantitative compensation formula is introduced in mathematics. During experiments, the absolute value of the compensated TCS is easy to be 10 × 10−6/°C~100 × 10−6/°C by individual adjustment and calibration of each device’s temperature compensation. Therefore, the feasibility and practicability of this technology are tested. Again, the disadvantages are discussed after the research of the experiment data and the improvement methods are also given in the designing period. This technology exhibits the great potential practical value of internal combustion engine cylinder pressure with volume manufacturing.

  3. 32 CFR 635.15 - Release of law enforcement information furnished by foreign governments or international...


    ... 32 National Defense 4 2010-07-01 2010-07-01 true Release of law enforcement information furnished... Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Release of Information § 635.15 Release of law enforcement information...

  4. Na2S, a fast-releasing H2S donor, given as suppository lowers blood pressure in rats.

    Tomasova, Lenka; Drapala, Adrian; Jurkowska, Halina; Wróbel, Maria; Ufnal, Marcin


    Hydrogen sulfide (H2S) is involved in blood pressure control. The available slow-releasing H2S-donors are poorly soluble in water and their ability to release H2S in biologically relevant amounts under physiological conditions is questionable. Therefore, new slow-releasing donors or new experimental approaches to fast-releasing H2S donors are needed. Hemodynamics and ECG were recorded in male, anesthetized Wistar Kyoto rats (WKY) and in Spontaneously hypertensive rats (SHR) at baseline and after: 1) intravenous (iv) infusion of vehicle or Na2S; 2) administration of vehicle suppositories or Na2S suppositories. Intravenously administered vehicle and vehicle suppositories did not affect mean arterial blood pressure (MABP) and heart rate (HR). Na2S administered iv caused a significant, but transient (2-5min) decrease in MABP. Na2S suppositories produced a dose-dependent hypotensive response that lasted ∼45min in WKY and ∼75-80min in SHR. It was accompanied by a decrease in HR in WKY, and an increase in HR in SHR. Na2S suppositories did not produce a significant change in corrected QT, an indicator of cardiotoxicity. Na2S suppositories increased blood level of thiosulfates, products of H2S oxidation. Na2S administered in suppositories exerts a prolonged hypotensive effect in rats, with no apparent cardiotoxic effect. SHR and WKY differ in hemodynamic response to the H2S donor. Suppository formulation of fast-releasing H2S donors may be useful in research, if a reference slow-releasing H2S donor is not available. Copyright © 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  5. ITRF2014: A new release of the International Terrestrial Reference Frame modeling nonlinear station motions

    Altamimi, Zuheir; Rebischung, Paul; Métivier, Laurent; Collilieux, Xavier


    For the first time in the International Terrestrial Reference Frame (ITRF) history, the ITRF2014 is generated with an enhanced modeling of nonlinear station motions, including seasonal (annual and semiannual) signals of station positions and postseismic deformation for sites that were subject to major earthquakes. Using the full observation history of the four space geodetic techniques (very long baseline interferometry (VLBI), satellite laser ranging (SLR), Global Navigation Satellite Systems (GNSS), and Doppler orbitography and radiopositioning integrated by satellite (DORIS)), the corresponding international services provided reprocessed time series (weekly from SLR and DORIS, daily from GNSS, and 24 h session-wise from VLBI) of station positions and daily Earth Orientation Parameters. ITRF2014 is demonstrated to be superior to past ITRF releases, as it precisely models the actual station trajectories leading to a more robust secular frame and site velocities. The ITRF2014 long-term origin coincides with the Earth system center of mass as sensed by SLR observations collected on the two LAGEOS satellites over the time span between 1993.0 and 2015.0. The estimated accuracy of the ITRF2014 origin, as reflected by the level of agreement with the ITRF2008 (both origins are defined by SLR), is at the level of less than 3 mm at epoch 2010.0 and less than 0.2 mm/yr in time evolution. The ITRF2014 scale is defined by the arithmetic average of the implicit scales of SLR and VLBI solutions as obtained by the stacking of their respective time series. The resulting scale and scale rate differences between the two solutions are 1.37 (±0.10) ppb at epoch 2010.0 and 0.02 (±0.02) ppb/yr. While the postseismic deformation models were estimated using GNSS/GPS data, the resulting parametric models at earthquake colocation sites were applied to the station position time series of the three other techniques, showing a very high level of consistency which enforces more the link

  6. In-Tunnel Blast Pressure Empirical Formulas for Detonations External, Internal and at the Tunnel Entrance

    LI Xiudi; ZHENG Yingren


    In order to define the loading on protective doors of an underground tunnel,the exact knowledge of the blast propagation through tunnels is needed.Thirty-three scale high-explosive tests are conducted to obtain in-tunnel blast pressure for detonations external,internal and at the tunnel entrance.The cross section of the concrete model tunnel is 0.67 m2.Explosive charges of TNT,ranging in mass from 400 g to 4 600 g,are detonated at various positions along the central axis of the model tunnel.Blast gages are flush-installed in the interior surface of the tunnel to record side-on blast pressure as it propagates down the tunnel.The engineering empirical formulas for predicting blast peak pressure are evaluated,and are found to be reasonably accurate for in-tunnel pressure prediction.

  7. Low internal pressure in femtoliter water capillary bridges reduces evaporation rates.

    Cho, Kun; Hwang, In Gyu; Kim, Yeseul; Lim, Su Jin; Lim, Jun; Kim, Joon Heon; Gim, Bopil; Weon, Byung Mook


    Capillary bridges are usually formed by a small liquid volume in a confined space between two solid surfaces. They can have a lower internal pressure than the surrounding pressure for volumes of the order of femtoliters. Femtoliter capillary bridges with relatively rapid evaporation rates are difficult to explore experimentally. To understand in detail the evaporation of femtoliter capillary bridges, we present a feasible experimental method to directly visualize how water bridges evaporate between a microsphere and a flat substrate in still air using transmission X-ray microscopy. Precise measurements of evaporation rates for water bridges show that lower water pressure than surrounding pressure can significantly decrease evaporation through the suppression of vapor diffusion. This finding provides insight into the evaporation of ultrasmall capillary bridges.

  8. The Effects of a Chactoid Scorpion Venom and Its Purified Toxins on Rat Blood Pressure and Mast Cells Histamine Release

    Philip Lazarovici


    Full Text Available The effect of the venom of the Chactoid family of scorpions on blood pressure was scantly investigated and was addressed in the present study using the venom of the Israeli scorpion, Scorpio maurus palmatus. Blood pressure in rats was monitored via cannulated femoral artery, while venom and toxins were introduced into femoral vein. Venom injection elicited a biphasic effect, expressed first by a fast and transient hypotensive response, which lasted up to 10 min, followed by a hypertensive response, which lasted up to one hour. It was found that these effects resulted from different venom components. Phospholipase A2 produced the hypotensive effect, while a non-enzymatic neurotoxic polypeptide fraction produced the hypertensive effect. Surprisingly, the main neurotoxic polypeptide to mice had no effect on blood pressure. In vitro experiments indicated that the hypertensive factors caused histamine release from the peritoneal mast cells, but this effect is assumed to be not relevant to their in vivo effect. In spite of the cytotoxic activity of phospholipase A2, it did not release histamine. These findings suggest that the effects of venom and isolated fractions on blood pressure parameters are mediated by different mechanisms, which deserve further pharmacological investigation.

  9. The effects of a chactoid scorpion venom and its purified toxins on rat blood pressure and mast cells histamine release.

    Ettinger, Keren; Cohen, Gadi; Momic, Tatjana; Lazarovici, Philip


    The effect of the venom of the Chactoid family of scorpions on blood pressure was scantly investigated and was addressed in the present study using the venom of the Israeli scorpion, Scorpio maurus palmatus. Blood pressure in rats was monitored via cannulated femoral artery, while venom and toxins were introduced into femoral vein. Venom injection elicited a biphasic effect, expressed first by a fast and transient hypotensive response, which lasted up to 10 min, followed by a hypertensive response, which lasted up to one hour. It was found that these effects resulted from different venom components. Phospholipase A₂ produced the hypotensive effect, while a non-enzymatic neurotoxic polypeptide fraction produced the hypertensive effect. Surprisingly, the main neurotoxic polypeptide to mice had no effect on blood pressure. In vitro experiments indicated that the hypertensive factors caused histamine release from the peritoneal mast cells, but this effect is assumed to be not relevant to their in vivo effect. In spite of the cytotoxic activity of phospholipase A₂, it did not release histamine. These findings suggest that the effects of venom and isolated fractions on blood pressure parameters are mediated by different mechanisms, which deserve further pharmacological investigation.

  10. Estimation of the in-cylinder air/fuel ratio of an internal combustion engine by the use of pressure sensors

    Tunestaal, Per


    This thesis investigates the use of cylinder pressure measurements for estimation of the in-cylinder air/fuel ratio in a spark ignited internal combustion engine. An estimation model which uses the net heat release profile for estimating the cylinder air/fuel ratio of a spark ignition engine is developed. The net heat release profile is computed from the cylinder pressure trace and quantifies the conversion of chemical energy of the reactants in the charge into thermal energy. The net heat release profile does not take heat- or mass transfer into account. Cycle-averaged air/fuel ratio estimates over a range of engine speeds and loads show an RMS error of 4.1% compared to measurements in the exhaust. A thermochemical model of the combustion process in an internal combustion engine is developed. It uses a simple chemical combustion reaction, polynominal fits of internal energy as function of temperature, and the first law of thermodynamics to derive a relationship between measured cylinder pressure and the progress of the combustion process. Simplifying assumptions are made to arrive at an equation which relates the net heat release to the cylinder pressure. Two methods for estimating the sensor offset of a cylinder pressure transducer are developed. Both methods fit the pressure data during the pre-combustion phase of the compression stroke to a polytropic curve. The first method assumes a known polytropic exponent, and the other estimates the polytropic exponent. The first method results in a linear least-squares problem, and the second method results in a nonlinear least-squares problem. The nonlinear least-squares problem is solved by separating out the nonlinear dependence and solving the single-variable minimization problem. For this, a finite difference Newton method is derived. Using this method, the cost of solving the nonlinear least-squares problem is only slightly higher than solving the linear least-squares problem. Both methods show good statistical

  11. Pipeline's natural frequency response due to internal pressure effect

    Massa, Andre L.L.; Guevara Junior, Nestor O. [Suporte - Consultoria e Projetos Ltda., Rio de Janeiro, RJ (Brazil); Galgoul, Nelson S. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil); Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil); Fernandes, Antonio C.; Coelho, Fabio M. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Coordenacao de Programas de Pos-graduacao de Engenharia


    A few years ago, a discussion about how internal pressure is treated in submarine pipelines has taken place. Galgoul et al (2004) have pointed out the conservatism of the latest recommendations for pipeline free-span evaluations associated to the way the axial force is considered in the determination of the pipeline natural frequency. Fyrileiv and Collberg (2005) have also discussed this point in defense of the effective axial force concept and its use in the natural frequency determination. In order to contribute to this aspect, an experimental test has been performed with a fully embedded pipeline which was pressurized. The main object consists in showing that the pipe is under tension (and not under compression) and, as a consequence, it is the authors' intention to prove that the natural frequency increases instead of reducing when the internal pressure is incremented. In addition to the test, a finite element model has been presented where this internal pressure effect is taken into account as it actually is (and not as an axial force) in order to show the real behavior of the wall stresses. Static analyses, as well as modal and transient analysis have been performed in order to compare theoretical results with the experimental test conducted. (author)

  12. Estimating the state of charge of MH-Ni batteries by measuring their stable internal pressure

    Zhang, Jian; Shao, Guangjie; Guo, Weiwen; Lou, Yuwan; Xia, Baojia


    Nickel metal hydride (MH-Ni) batteries are widely used in hybrid electric vehicles (HEVs). Estimating a battery's state of charge (SOC) remains challenging in practical applications, and it is also the core technology. Because MH-Ni batteries exhibit high rates of self-discharge and have flat and broad charge-discharge voltage plateaus, the estimation of their SOC through their voltage, current, internal resistance, and temperature is not accurate and has a large cumulative error. In this study, a new method for estimating SOC based on battery's stable internal pressure is proposed using the one-to-one correspondence between the hydrogen equilibrium pressure and the reversible hydrogen-storage capacity described by the pressure-concentration-isotherm (P-C-T) curves of hydrogen storage alloys. The actual SOC and the stable internal pressure of the battery have a one-to-one correspondence after the battery was stored at different temperatures and SOCs, and this relationship is maintained after different cycling number and after four years of storage.

  13. Elastic-plastic Transition of Transversely Isotropic Thick-walled Rotating Cylinder under Internal Pressure

    Sanjeev Sharma


    Full Text Available Elastic-plastic stresses for a transversely isotropic thick-walled rotating cylinder under internal pressure have been obtained by using Seth’s transition theory. It has been observed that a thick-walled circular cylinder made of isotropic material yields at the internal surface at a high pressure as compared to cylinder made of transversely isotropic material. With the increase in angular speed, much less pressure is required for initial yielding at the internal surface for transversely isotropic material as compared to isotropic material. For fullyplastic state, circumferential stress is maximum at the external surface. Thick-walled circular cylinder made of transversely isotropic material requires high percentage increase in pressure to become fully plastic as compared to isotropic cylinder. Therefore, circular cylinder made of transversely isotropic material is on the safer side of the design as compared to cylinder made of  isotropic material.Defence Science Journal, 2009, 59(3, pp.260-264, DOI:

  14. Harmonic components of cylinder pressure variation and their characteristics for combustion noise in internal combustion engines

    Lee, S.R.; Miyamoto, Noboru; Murayama, Tadashi


    Combustion noise is a serious problem in internal combustion engines, especially diesel engines. Although the cylinder pressure variation is easily visible tool to evaluate the combustion noise and thermal efficiency, the exciting force in engine combustion noise has not been completely determined. Cylinder pressure variation for different combustion behaviors and their harmonic components were calculated and an attempt was made to correlate the various components. It was found that the logarithmic harmonic components of cylinder pressure variations, the cylinder pressure level (CPL) can be described by a function with four variables, the values of cylinder pressure variation. The results of this paper is summarized as follows: 1) A relationship was established between CPL and four characteristic values describing the cylinder pressure and variation diagram. 2) Harmonic components of cylinder pressure variations are described by a linear function with four variables and four characteristic values. 3) In this case, the coefficients of the four variables depend solely on the order of engine revolutions and are independent of combustion behavior and engine operating conditions. (13 figs, 7 refs)

  15. Failure assessment of aluminum liner based filament-wound hybrid riser subjected to internal hydrostatic pressure

    Dikshit, Vishwesh; Seng, Ong Lin; Maheshwari, Muneesh; Asundi, A.


    The present study describes the burst behavior of aluminum liner based prototype filament-wound hybrid riser under internal hydrostatic pressure. The main objective of present study is to developed an internal pressure test rig set-up for filament-wound hybrid riser and investigate the failure modes of filament-wound hybrid riser under internal hydrostatic burst pressure loading. The prototype filament-wound hybrid riser used for burst test consists of an internal aluminum liner and outer composite layer. The carbon-epoxy composites as part of the filament-wound hybrid risers were manufactured with [±55o] lay-up pattern with total composite layer thickness of 1.6 mm using a CNC filament-winding machine. The burst test was monitored by video camera which helps to analyze the failure mechanism of the fractured filament-wound hybrid riser. The Fiber Bragg Grating (FBG) sensor was used to monitor and record the strain changes during burst test of prototype filament-wound hybrid riser. This study shows good improvements in burst strength of filament-wound hybrid riser compared to the monolithic metallic riser. Since, strain measurement using FBG sensors has been testified as a reliable method, we aim to further understand in detail using this technique.

  16. FOREWORD: CCM Second International Seminar: Pressure Metrology from 1 kPa to 1 GPa

    Molinar, G. F.


    The Comité Consultatif pour la Masse et les Grandeurs Apparentées (CCM), through its High Pressure and Medium Pressure Working Groups, organized this Second International Seminar on Pressure Metrology from 1 kPa to 1 GPa, which was held at the Laboratoire National d'Essais (LNE), Paris, France, from 2 to 4 June 1993. The scope of the seminar was to review the state of the art of pressure measurements in the 1 kPa to I GPa pressure range and to present innovative contributions by standards laboratories, universities and industry. The seminar was organized in six sessions: liquid-column manometers; piston gauge pressure standards; properties of liquids and gases relevant to pressure metrology; pressure transducers and transfer standards; pressure standard comparison (methods and results); dynamic pressure measurements. Each session opened with the presentation of a review paper on major requirements in that field and, at the end of the seminar, a general discussion was organized on the actual limits of accuracy of static and dynamic pressure measurements in fluid media, and the fundamental problems in pressure metrology between 1 kPa and 1 GPa. The seminar was attended by sixty scientists from twenty-four countries, all working in the field of pressure measurements. Forty-nine papers were presented. The participation of scientists from so many countries indicates the importance of pressure metrology from the scientific and industrial points of view. Most papers were presented by scientists from national standards laboratories, with eight papers from universities and four from industry. Eleven papers reported the results of cooperative work involving metrological institutions dealing with high pressure, generally national standards laboratories, an indication that scientific links are already well established at this level. Links are also strengthening between industry and standards laboratories. Although industrial participation at the seminar was relatively small

  17. Flavor release measurement by atmospheric pressure chemical ionization ion trap mass spectrometry, construction of interface and mathematical modeling of release profiles

    Haahr, Anne-Mette; Madsen, Henrik; Smedsgaard, Jørn


    An instrumental on-line retronasal flavor analysis was developed to obtain information about the release of flavor compounds in expired air from humans during eating. The volatile flavor compounds were measured by ion trap mass spectrometry with an atmospheric pressure chemical ionization source...... (APCI). An interface was designed to sample the breath directly from the nose. The repeat-ability in vitro for seven different flavor compounds came out with relative standard derivation less than 10% in most cases, which is acceptable. In vitro quantification was carried out by a determination...... of the concentration in the gas phase over a flavor solution by GC/MS, followed by measurements of intensities by the APCI ion trap. Ion suppression by acetone in the breath was negligible at concentration levels relevant in these experiments. The instrumental limits of detection for menthone and menthol coincide...

  18. IAEA international studies on irradiation embrittlement of reactor pressure vessel steels

    Brumovsky, M. [Nuclear Research Institute Rez plc (Czech Republic); Steele, L.E. [Chief Scientific Investigator of the Programme, Springfield, VA (United States)


    In last 25 years, three phases a Co-operative Research Programme on Irradiation Embrittlement of Reactor Pressure Vessel Steels has been organized by the International Atomic Energy Agency. This programme started with eight countries in 1971 and finally 16 countries took part in phase III of the Programme in 1983. Several main efforts were put into preparation of the programme, but the principal task was concentrated on an international comparison of radiation damage characterization by different laboratories for steels of {open_quotes}old{close_quotes} (with high impurity contents) and {open_quotes}advanced{close_quotes} (with low impurity contents) types as well as on development of small scale fracture mechanics procedures applicable to reactor pressure vessel surveillance programmes. This year, a new programme has been opened, concentrated mostly on small scale fracture mechanics testing.

  19. Effects of internal pressure and surface tension on the growth-induced wrinkling of mucosae.

    Xie, Wei-Hua; Li, Bo; Cao, Yan-Ping; Feng, Xi-Qiao


    Surface wrinkling of mucosae is crucial for the biological functions of many living tissues. In this paper, we investigate the instability of a cylindrical tube consisting of a mucosal layer and a submucosal layer. Our attention is focused on the effects of internal pressure and surface tension on the critical condition and mode number of surface wrinkling induced by tissue growth. It is found that the internal pressure plays a stabilizing role but basically has no effect on the critical mode number. Surface tension also stabilizes the system and reduces the critical mode number of surface patterns. Besides, the thinner the mucosal layer, the more significant the effect of surface tension. This work may help gain insights into the surface wrinkling and morphological evolution of such tubular organs as airways and esophagi. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. The effect of lateral internal sphincterotomy on resting anal sphincter pressures

    Peker, Kemal; YILMAZ, İsmayil; DEMİRYILMAZ, İsmail; İNAL, Abdullah; Işik, Arda


    Anal fissures are one of the most common proctologic disorders. This study aimed to investigate alterations in anal sphincteric resting pressures after lateral internal sphincterotomy, which was performed for chronic anal fissure treatment. Materials and methods: Fifty-six (68.3%) male and 26 (31.7%) female patients were included in this study. Patients complicated with fistula-in-ano, abscess, cancer, inflammatory bowel disease, dermatitis, poor general condition, allergy to any of the stan...

  1. Pressure ulcers in patients hospitalized in Internal Medicine: associated factors and mortality.

    Díez-Manglano, J; Fernández-Jiménez, C; Lambán-Aranda, M P; Landa-Santesteban, M C; Isasi de Isasmendi-Pérez, S; Moreno-García, P; Bejarano-Tello, E; Barranco-Usón, J; Munilla-López, E; Del Corral-Beamonte, E


    To determine the prevalence of pressure ulcers in patients hospitalized in internal medicine and the clinical factors and risk of death associated with its presence. Prospective cohort study with patients hospitalized in internal medicine. We recorded the age, sex, presence of pressure ulcers, degree of ulceration, Barthel index, Norton scale, major diagnostic category, length of hospital stay and weight of the diagnosis-related groups. We compared the clinical characteristics of the patients with or without ulcers and analysed the mortality after 3 years based on the presence of ulcers. The study included 699 patients, 100 of whom (14.3%) had pressure ulcers (27 with grade I, 17 with grade II, 21 with grade III, 25 with grade IV and 10 with unknown grade). The Barthel index (OR 0.985; 95% CI 0.972-0.998; p=.022) and Norton scale (OR 0.873; 95% CI 0.780-0.997; p=.018) are independently associated with ulcers. Twenty-three percent of the patients with ulcers died during hospitalization, 68% died within a year, and 83% died within 3 years. The presence of pressure ulcers was independently associated with mortality (HR, 1.531; 95% CI 1.140-2.056; p=.005). Pressure ulcers are common in patients hospitalized in internal medicine, and their presence is associated with higher short, medium and long-term mortality. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

  2. Wrinkling behavior in tube hydroforming coupled with internal and external pressure

    Cui X.L.


    Full Text Available Control and use of wrinkles is a challenge in tube hydroforming because wrinkle was always considered as one of the defects of tubes from the traditional view. In this paper, a dedicated experimental setup was designed and manufactured, using which the investigation of wrinkling behavior coupled with internal and external pressure can be realized. The effect of internal or external pressure on 5A02 aluminum alloy tubes and 0Cr18Ni9 stainless steel tubes were all investigated using this setup. It was found that the number and shape of wrinkles are strongly dependent on the internal or external pressure. More important is that the geometrical configuration of wrinkles can be perfectly characterized using the Gauss function rather than the sine function adopted in the published literature. In addition, the fitted Gauss functions for every wrinkle were integrated in order to compare their area with the corresponding area of die cavity, so as to obtain the appropriate process parameters for the useful wrinkle, which can be formed in advance and then flatted in the calibration stage.

  3. Case report: (Pre)syncopal symptoms associated with a negative internal jugular venous pressure

    Olesen, Niels; van Lieshout, Johannes J; Fisher, James P;


    A siphon is suggested to support cerebral blood flow but appears not to be established because internal jugular venous (IJV) pressure is close to zero in upright humans. Thus, in eleven young healthy males, IJV pressure was 9 ± 1 mmHg (mean ± SE) when supine and fell to 3 ± 1 mmHg when seated......, and middle cerebral artery mean blood velocity (MCA Vmean; P ... MCA Vmean decreased and yet within the time of observation ScO2 was not necessarily affected. These findings support the hypothesis that a negative IJV pressure that is a prerequisite for creation of a siphon provokes venous collapse inside the dura, and thereby limits rather than supports CBF....

  4. Video News release (A-roll) International Conference on Translational Research in Radio-Oncology and Physics for Health in Europe

    CERN Visual Media Office; Paola Catapano


    Video News Release (A-roll) accompanying the Press Release announcing the International Conference on Translational Research in Radio-Oncology and Physics for Health in Europe, organized by CERN at the International Conference Centre Geneva from February 27 to March 2.

  5. Particle image velocimetry for quantification of high pressure CO 2 release

    Jong, A. de; Spruijt, M.


    In the current work evaluation of CO2 release velocity profiles is determined using Particle Image Velocimetry (PIV). The formation of solid CO2 particles using the rapid expansion of nozzle flow is used as a seeder particle, making the method truly nonintrusive and negates the use of special seeder

  6. Development of pressurized internally circulating fluidized bed combustion technology; Kaatsu naibu junkan ryudosho boiler no kaihatsu

    Ishihara, I. [Center for Coal Utilization, Japan, Tokyo (Japan); Nagato, S.; Toyoda, S. [Ebara Corp., Tokyo (Japan)


    The paper introduced support research on element technology needed for the design of hot models of the pressurized internally circulating fluidized bed combustion boiler in fiscal 1995 and specifications for testing facilities of 4MWt hot models after finishing the basic plan. The support research was conduced as follows: (a) In the test for analysis of cold model fluidization, it was confirmed that each characteristic value of hot models is higher than the target value. Further, calculation parameters required for computer simulation were measured and data on the design of air diffusion nozzle for 1 chamber wind box were sampled. (b) In the CWP conveyance characteristic survey, it was confirmed that it is possible to produce CWP having favorable properties. It was also confirmed that favorable conveyability can be maintained even if the piping size was reduced down to 25A. (c) In the gas pressure reducing test, basic data required for the design of gas pressure reducing equipment were sampled. Specifications for the fluidized bed combustion boiler of hot models are as follows: evaporation amount: 3070kg/h, steam pressure: 1.77MPa, fuel supply amount: 600kg-coal/h, boiler body: cylinder shape water tube internally circulating fluidized bed combustion boiler. 4 refs., 4 figs.

  7. Estimation of internal nutrient release in large shallow Lake Taihu, China


    Based on field investigation of wave, sediment suspension and the changes in nutrient concentration of the water column in Lake Taihu, China, we proposed two release models to quantify nutrient release under static and dynamic conditions, respectively. Under static conditions, nutrient release from sediments to the overlying water mainly depends on chemical diffusion induced by concentration gradient, in which the nutrient release is controlled by the temperature, dissolved oxygen concentration in the sediment-water interface, oxidation-reduction potential and the concentration difference between porewater and overlying water. Under dynamic condition (or disturbed condition),both dissolved and particulate nutrients in sediments are released into the water column because of wind-induced sediment suspension. The amount of nutrient release under dynamic conditions is larger than that under the static condition. The release of dissolved nutrients, however, does not increase because the wind induced turbulence made oxidation of metallic elements such as Fe (ferric iron), Mn which are capable of precipitating soluble reactive phosphate (SRP). Under dynamic conditions, therefore, the release of total phosphorus (TP) increases dramatically but the release of SRP is close to those under static conditions. In sediments of Lake Taihu, high Fe content leads to a high ratio of Fe to P contents in sediments (Fe:P ratio). Under dynamic conditions, therefore, nutrient release is controlled by the intensity of disturbance, sediment consolidation and nutrient content in sediments.As for dissolved nutrients, especially SRP, the release is also controlled by the intensity of dynamic re-oxidation, Fe content in sediments and nutrient concentration gradient between porewater and overlying water. Based on these two release modes, the release flux in Lake Taihu has been estimated. In the static condition (i.e. laboratory experimental condition), total release of NH4+-N for whole lake is

  8. Pressure Ulcer Risk in the Incontinent Patient: Analysis of Incontinence and Hospital-Acquired Pressure Ulcers From the International Pressure Ulcer Prevalence™ Survey.

    Lachenbruch, Charlie; Ribble, David; Emmons, Kirsten; VanGilder, Catherine


    To measure the prevalence of incontinence in the 2013-2014 International Pressure Ulcer Prevalence (IPUP) surveys and determine the relative risk of developing a facility-acquired pressure ulcers (FAPUs) by stage and by Braden Scale score groupings. The IPUP survey is an observational, cross-sectional cohort database designed to determine the frequency and severity of pressure ulcers in various populations. The survey includes acute care (91.4%), long-term acute care (1.7%), rehabilitation patients (1.7%) and long-term care residents (5.2%). Geographic distribution included 182,832 patients in the United States, 22,282 patients in Canada, and the rest of the world, primarily in Europe and the Middle East. We analyzed data from the 2013 and 2014 IPUP surveys to better understand the relationship between incontinence and the frequency and severity of FAPUs. The IPUP survey is an annual voluntary survey of patients who are hospitalized or who reside in long-term care facilities. Data were collected over a 24-hour period within each participating facility. Data collection included limited demographics, presence and stage of pressure ulcers, and pressure ulcer risk assessment score (Braden Scale for Pressure Sore Risk, Braden Q, Norton, Waterlow, and others). In addition, data were collected on pertinent pressure ulcer risk factors including the number of linen layers, use of a pressure redistributing surface, adherence to repositioning schedule, and whether moisture management was provided in the last 24 hours. We aggregated data by urinary, urinary catheter, fecal, fecal management system, double (urinary and fecal), and ostomy incontinence category. If patients were managed by indwelling urinary catheter or fecal management systems, they were considered incontinent in this analysis. In order to analyze ulcers likely to be affected by incontinence, we defined a subset of ulcers as Relevant Pressure Ulcers, which are ulcers that are facility-acquired, non

  9. The effect of nitric oxide releasing cream on healing pressure ulcers

    Saidkhani, Vahid; Asadizaker, Marziyeh; Khodayar, Mohammad Javad; Latifi, Sayed Mahmoud


    Background: Pressure ulcer is one of the main concerns of nurses in medical centers around the world, which, if untreated, causes irreparable problems for patients. In recent years, nitric oxide (NO) has been proposed as an effective method for wound healing. This study was conducted to determine the effect of nitric oxide on pressure ulcer healing. Materials and Methods: In this clinical trial, 58 patients with pressure ulcer at hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences were homogenized and later divided randomly into two groups of treatment (nitric oxide cream; n = 29) and control (placebo cream; n = 29). In this research, the data collection tool was the Pressure Ulcer Scale for Healing (PUSH). At the outset of the study (before using the cream), the patients' ulcers were examined weekly in terms of size, amount of exudates, and tissue type using the PUSH tool for 3 weeks. By integrating these three factors, wound healing was determined. Data were analyzed using SPSS. Results: Although no significant difference was found in terms of the mean of score size, the amount of exudates, and the tissue type between the two groups, the mean of total score (healing) between the two groups was statistically significant (P = 0.04). Conclusions: Nitric oxide cream seems to accelerate wound healing. Therefore, considering its easy availability and cost-effectiveness, it can be used for treating pressure ulcers in the future. PMID:27186212

  10. The effect of nitric oxide releasing cream on healing pressure ulcers.

    Saidkhani, Vahid; Asadizaker, Marziyeh; Khodayar, Mohammad Javad; Latifi, Sayed Mahmoud


    Pressure ulcer is one of the main concerns of nurses in medical centers around the world, which, if untreated, causes irreparable problems for patients. In recent years, nitric oxide (NO) has been proposed as an effective method for wound healing. This study was conducted to determine the effect of nitric oxide on pressure ulcer healing. In this clinical trial, 58 patients with pressure ulcer at hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences were homogenized and later divided randomly into two groups of treatment (nitric oxide cream; n = 29) and control (placebo cream; n = 29). In this research, the data collection tool was the Pressure Ulcer Scale for Healing (PUSH). At the outset of the study (before using the cream), the patients' ulcers were examined weekly in terms of size, amount of exudates, and tissue type using the PUSH tool for 3 weeks. By integrating these three factors, wound healing was determined. Data were analyzed using SPSS. Although no significant difference was found in terms of the mean of score size, the amount of exudates, and the tissue type between the two groups, the mean of total score (healing) between the two groups was statistically significant (P = 0.04). Nitric oxide cream seems to accelerate wound healing. Therefore, considering its easy availability and cost-effectiveness, it can be used for treating pressure ulcers in the future.

  11. Pavlovian conditioning of corticotropin-releasing factor-induced increase of blood pressure and corticosterone secretion in the rat.

    Kreutz, M; Hellhammer, D; Murison, R; Vetter, H; Krause, U; Lehnert, H


    Corticotropin-releasing factor (CRF) is clearly involved in the central regulation of the pituitary-adrenal axis and, moreover, of autonomic nervous system functions. Enhanced sympathetic activity with subsequent increases in blood pressure and heart rate and attenuation of the baroreceptor reflex results from the intracerebroventricular (i.c.v.) administration of CRF. Additionally, the peptide has a variety of potent effects on behavioural responses in animals similar to those observed after an experimentally evoked stress. It was therefore of obvious interest to examine whether CRF is a possible mediator of the learning processes associated with physiological stress reaction patterns. This report clearly demonstrates a classical conditioning of the endocrine (i.e. corticosterone secretion) and haemodynamic (i.e. blood pressure) sequelae following central CRF application and thus indicates that this mechanism is of physiological significance for learned stress responses.

  12. PREFACE: International Conference on High Pressure Science and Technology, Joint AIRAPT-22 & HPCJ-50

    Viña, Luis; Tejedor, Carlos; Calleja, José M.


    The International Joint AIRAPT-22 & HPCJ-50 Conference was held in Odaiba, Tokyo, on 26-31 July 2009. About 480 scientists from 24 countries attended the conference and 464 papers, including 3 plenary lectures, 39 invited talks, and 156 oral presentations, were presented. It is my great pleasure to present this proceedings volume, which is based on the high quality scientific works presented at the conference. The International AIRAPT conference has been held every two years in various countries around the world since 1965, while High Pressure Conference of Japan (HPCJ) has been held annually since 1959 in various Japanese cities. Pressure is a fundamental parameter to control the property of matter. As a result, both AIRAPT and HPCJ have become highly multidisciplinary, and cover Physics, Chemistry, Materials Science, Earth and Planetary Sciences, Biosciences, Food Science, and Technology. Although each discipline has a unique target, they all have high-pressure research in common. This proceedings volume includes about 200 papers of state-of-the-art studies from numerous fields. I hope this proceedings volume provides excellent pieces of information in various fields to further advance high-pressure research. Conference logo Takehiko Yagi Conference Chairman Institute for Solid State Physics The University of Tokyo 7 December 2009 Conference photograph Participants at the conference venue, Tokyo International Exchange Center, Odaiba, Tokyo, Japan. Editor in Chief TAKEMURA Kenichi National Institute for Materials Science, Japan Editorial board Tadashi KONDO Osaka University, Japan Hitoshi MATSUKI The University of Tokushima, Japan Nobuyuki MATUBAYASI Kyoto University, Japan Yoshihisa MORI Okayama University of Science, Japan Osamu OHTAKA Osaka University, Japan Chihiro SEKINE Muroran Institute of Technology, Japan

  13. An experimental model of episodic gas release through fracture of fluid confined within a pressurized elastic reservoir

    Rocco, Stefano; Woods, Andrew W.; Harrington, Jon; Norris, Simon


    We present new experiments that identify a mechanism for episodic release of gas from a pressurized, deformable reservoir confined by a clay seal, as a result of the transition from bulk deformation to channel growth through the clay. Air is injected into the center of a thin cylindrical cell initially filled with a mixture of bentonite clay and water. For sufficiently dry mixtures, the pressure initially increases with little volume change. On reaching the yield stress of the clay-water mixture, the lid of the cell then deforms elastically and an air-filled void forms in the center of the cell as the clay is driven radially outward. With continued supply of air, the pressure continues to increase until reaching the fracture strength of the clay. A fracture-like channel then forms and migrates to the outer edge of the cell, enabling the air to escape. The pressure then falls, and the clay flows back toward the center of the cell and seals the channel so the cycle can repeat. The phenomena may be relevant at mud volcanoes.

  14. The Covariance of Scalar Fields Scattered by Pressure-Release Randomly Rough Surfaces.


    The Mean Scattered Pressure .- The surfaces to be dealt with will be random stationary, ’. described by "(x",y"). "(x",y") is a sample of a...developed in Chapter 3 when the surface involved is the fully developed, non-directional ocean spectrum -see Appendix. For convience we list the most

  15. Rod internal pressure of spent nuclear fuel and its effects on cladding degradation during dry storage

    Kim, Ju-Seong; Hong, Jong-Dae; Yang, Yong-Sik; Kook, Dong-Hak


    Temperature and hoop stress limits have been used to prevent the gross rupture of spent nuclear fuel during dry storage. The stress due to rod internal pressure can induce cladding degradation such as creep, hydride reorientation, and delayed hydride cracking. Creep is a self-limiting phenomenon in a dry storage system; in contrast, hydride reorientation and delayed hydride cracking are potential degradation mechanisms activated at low temperatures when the cladding material is brittle. In this work, a conservative rod internal pressure and corresponding hoop stress were calculated using FRAPCON-4.0 fuel performance code. Based on the hoop stresses during storage, a study on the onset of hydride reorientation and delayed hydride cracking in spent nuclear fuel was conducted under the current storage guidelines. Hydride reorientation is hard to occur in most of the low burn-up fuel while some high burn-up fuel can experience hydride reorientation, but their effect may not be significant. On the other hand, delayed hydride cracking will not occur in spent nuclear fuel from pressurized water reactor; however, there is a lack of confirmatory data on threshold intensity factor for delayed hydride cracking and crack size distribution in the fuel.

  16. Prospective randomized study of 2 different techniques for endoscopic iliopsoas tendon release in the treatment of internal snapping hip syndrome.

    Ilizaliturri, Victor M; Chaidez, Carlos; Villegas, Patricio; Briseño, Arcadio; Camacho-Galindo, Javier


    To evaluate the short-term results of 2 different techniques of endoscopic iliopsoas tendon release for the treatment of internal snapping hip syndrome. Between January 2005 and January 2007, a consecutive series of patients with the diagnosis of internal snapping hip syndrome was treated with endoscopic release of the iliopsoas tendon. The patients were randomized into 2 different groups. Patients in group 1 were treated with endoscopic iliopsoas tendon release at the lesser trochanter, and patients in group 2 were treated with endoscopic transcapsular psoas release from the peripheral compartment. Hip arthroscopy of both the central and peripheral compartments was performed in both groups using the lateral approach. Associated injuries were identified and treated arthroscopically. Postoperative physical therapy was the same for both series, and each patient received 400 mg of celecoxib daily for 21 days after surgery. Preoperative and postoperative Western Ontario MacMaster (WOMAC) scores and imaging studies were evaluated. Nineteen patients were included in the study: 10 in group 1 (5 male and 5 female; average age, 29.5 years) and 9 in group 2 (8 female and 1 male; average age, 32.6 years). No statistical difference was found in group composition. Associated injuries were found and treated in 8 patients in group 1 and 7 patients in group 2. No statistical difference was found between groups in preoperative WOMAC scores, and every patient in both groups had an improvement in the WOMAC score. Improvements in WOMAC scores were statistically significant in both groups, and no difference was found in postoperative WOMAC results between groups. No complications were seen. Iliopsoas tendon release at the level of the lesser trochanter or at the level of the hip joint using a transcapsular technique is effective and reproducible. We found no clinical difference in the results of both techniques.

  17. Damage Control Plan for International Space Station Recharge Tank Assembly Composite Overwrapped Pressure Vessel

    Cook, Anthony J.


    As NASA has retired the Space Shuttle Program, a new method of transporting compressed gaseous nitrogen and oxygen needed to be created for delivery of these crucial life support resources to the International Space Station (ISS). One of the methods selected by NASA includes the use of highly pressurized, unprotected Recharge Tank Assemblies (RTAs) utilizing Composite Overwrapped Pressure Vessels (COPVs). A COPV consists of a thin liner wrapped with a fiber composite and resin or epoxy. It is typically lighter weight than an all metal pressure vessel of similar volume and therefore provides a higher-efficiency means for gas storage. However COPVs are known to be susceptible to damage resulting from handling, tool drop impacts, or impacts from other objects. As a result, a comprehensive Damage Control Plan has been established to mitigate damage to the RTA COPV throughout its life cycle. The DCP is intended to evaluate and mitigate defined threats during manufacturing, shipping and handling, test, assembly level integration, shipment while pressurized, launch vehicle integration and mission operations by defining credible threats and methods for preventing potential damage while still maintaining the primary goal of resupplying ISS gas resources. A comprehensive threat assessment is performed to identify all threats posed to the COPV during the different phases of its lifecycle. The threat assessment is then used as the basis for creating a series of general inspection, surveillance and reporting requirements which apply across all phases of the COPV's life, targeted requirements only applicable to specific work phases and a series of training courses for both ground personnel and crew aboard the ISS. A particularly important area of emphasis deals with creating DCP requirements for a highly pressurized, large and unprotected RTA COPV for use during Inter Vehicular Activities (IVA) operations in the micro gravity environment while supplying pressurized gas to the

  18. Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

    Jeong, Jae Kwan; Choi, In Soo; Kang, Hyun Gu; Hur, Tai Young


    This study investigated the effects of gonadotrophin-releasing hormone (GnRH) administration (Experiment 1) and a controlled internal drug-releasing (CIDR) insert (Experiment 2) after timed artificial insemination (TAI) on the pregnancy rates of dairy cows. In Experiment 1, 569 dairy cows that underwent TAI (day 0) following short-term synchronization with prostaglandin F2α were randomly allocated into two groups: no further treatment (control, n = 307) or injection of 100 µg of gonadorelin on day 5 (GnRH, n = 262). In Experiment 2, 279 dairy cows that underwent TAI (day 0) following Ovsynch were randomly allocated into two groups: no further treatment (control, n = 140) or CIDR insert treatment from days 3.5 to 18 (CIDR, n = 139). The probability of pregnancy following TAI did not differ between the GnRH (34.4%) and control (31.6%, p > 0.05) groups. However, the probability of pregnancy following TAI was higher (odds ratio: 1.74, p < 0.05) in the CIDR group (51.1%) than in the control group (39.3%). Overall, CIDR insert treatment at days 3.5 to 18 increased pregnancy rates relative to non-treated controls, whereas a single GnRH administration on day 5 did not affect the pregnancy outcomes of dairy cows. PMID:27030200

  19. The effects of ram-pressure stripping on the internal kinematics of simulated spiral galaxies

    Kronberger, T; Unterguggenberger, S; Schindler, S; Ziegler, B L


    We investigate the influence of ram-pressure stripping on the internal gas kinematics of simulated spiral galaxies. Additional emphasis is put on the question of how the resulting distortions of the gaseous disc are visible in the rotation curve and/or the full 2D velocity field of galaxies at different redshifts. A Milky-Way type disc galaxy is modelled in combined N-body/hydrodynamic simulations with prescriptions for cooling, star formation, stellar feedback, and galactic winds. This model galaxy moves through a constant density and temperature gas, which has parameters similar to the intra-cluster medium (ICM). Rotation curves (RCs) and 2D velocity fields of the gas are extracted from these simulations in a way that follows the procedure applied to observations of distant, small, and faint galaxies as closely as possible. We find that the appearance of distortions of the gaseous disc due to ram-pressure stripping depends on the direction of the acting ram pressure. In the case of face-on ram pressure, the...

  20. Proposed apparatus for measuring internal friction in rocks at high temperatures and pressures: a design analysis

    Bonner, B.P.


    An apparatus is described that measures internal friction in rocks at high temperatures (approximately 800/sup 0/C) and pressures (approximately 1.0 GPa). Steady oscillations (approximately 1.0 Hz) are induced in a jacketed sample while coaxial capacitive transducers monitor the resulting radial strain. Sample strains are continuously compared to the deformation of a low-loss standard, which acts as a stress transducer. The stress state produced is uniaxial stress. We use the theory of viscoelasticity to partition the loss into components depending on pure shear and dilatation. The theoretical results emphasize the importance of ultimately measuring each loss independently.

  1. Lattice Boltzmann equation calculation of internal, pressure-driven turbulent flow

    Hammond, L A; Care, C M; Stevens, A


    We describe a mixing-length extension of the lattice Boltzmann approach to the simulation of an incompressible liquid in turbulent flow. The method uses a simple, adaptable, closure algorithm to bound the lattice Boltzmann fluid incorporating a law-of-the-wall. The test application, of an internal, pressure-driven and smooth duct flow, recovers correct velocity profiles for Reynolds number to 1.25 x 10 sup 5. In addition, the Reynolds number dependence of the friction factor in the smooth-wall branch of the Moody chart is correctly recovered. The method promises a straightforward extension to other curves of the Moody chart and to cylindrical pipe flow.

  2. The Internal Pressure and Cohesive Energy Density of Liquid Metallic Elements

    Marcus, Yizhak


    The internal pressures, P_{int}, of practically all the liquid metallic elements in the periodic table up to plutonium (except highly radioactive ones) at their melting points were calculated from data in the literature. They are compared with the respective cohesive energy densities, ced, obtained from the literature data too. The ratios P_{int}{/}ced for various liquids are ranked as follows: molten salts < polar/hydrogen-bonded molecular solvents ˜ liquid metals < room temperature ionic liquids < nonpolar molecular solvents, and the reverse of this list reflects the relative strengths of the mutual interactions of the particles constituting these liquids.

  3. Internal hydration of a metal-transporting ATPase is controlled by membrane lateral pressure

    Fahmy, Karim [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Biophysics; Fischermeier, E. [Technische Univ. Dresden (Germany); Pospisil, P. [A.S.C. R., Prague (Czech Republic). J. Heyrovsky Inst. Physical Chemistry; Solioz, M. [Bern Univ. (Switzerland); Sayed, A.; Hof, M.


    The active transport of ions across biological mem branes requires their hydration shell to interact with the interior of membrane proteins. However, the influence of the external lipid phase on internal dielectric dynamics is hard to access by experiment. Using the octahelical transmembrane architecture of the copper-transporting P{sub 1B}-type ATPase from Legionella pneumophila (LpCopA) as a model structure, we have established the site-specific labeling of internal cysteines with a polarity-sensitive fluorophore. This enabled dipolar relaxation studies in a solubilized form of the protein and in its lipid-embedded state in nano-discs (NDs). Time-dependent fluorescence shifts revealed the site-specific hydration and dipole mobility around the conserved ion-binding motif. The spatial distribution of both features is shaped significantly and independently of each other by membrane lateral pressure.

  4. WRAITH - A Computer Code for Calculating Internal and External Doses Resulting From An Atmospheric Release of Radioactive Material

    Scherpelz, R. I.; Borst, F. J.; Hoenes, G. R.


    WRAITH is a FORTRAN computer code which calculates the doses received by a standard man exposed to an accidental release of radioactive material. The movement of the released material through the atmosphere is calculated using a bivariate straight-line Gaussian distribution model, with Pasquill values for standard deviations. The quantity of material in the released cloud is modified during its transit time to account for radioactive decay and daughter production. External doses due to exposure to the cloud can be calculated using a semi-infinite cloud approximation. In situations where the semi-infinite cloud approximation is not a good one, the external dose can be calculated by a "finite plume" three-dimensional point-kernel numerical integration technique. Internal doses due to acute inhalation are cal.culated using the ICRP Task Group Lung Model and a four-segmented gastro-intestinal tract model. Translocation of the material between body compartments and retention in the body compartments are calculated using multiple exponential retention functions. Internal doses to each organ are calculated as sums of cross-organ doses, with each target organ irradiated by radioactive material in a number of source organs. All doses are calculated in rads, with separate values determined for high-LET and low-LET radiation.

  5. A Review of Energy Release Processes from the Failure of Pneumatic Pressure Vessels


    RT) is not a good approximation. There are several equations cf state that can be used for real gases (e.g., Van der Waal’s, Beattie - Bridgeman ...The gas pressure can be written in terms of an appropriate equation of state for either an ideal or real gas. Initial fragment velocity is...assumption3 reduce Equation (1) to: -w - AE - AU (2) The ideal gas law states that foz the expailsion of a gas: W - -C, AT (3) where: C, - constant

  6. Calculation of Internal Energy and Pressure of Dense hydrogen Plasma by Direct Path Integral Monte Carlo Approach

    刘松芬; 胡北来


    The internal energy and pressure of dense hydrogen plasma are calculated by the direct path integral Monte Carlo approach. The Kelbg potential is used as interaction potentials both between electrons and between protons and electrons in the calculation. The complete formulae for internal energy and pressure in dense hydrogen plasma derived for the simulation are presented. The correctness of the derived formulae are validated by the obtained simulation results. The numerical results are discussed in details.

  7. Peptidases prevent μ-opioid receptor internalization in dorsal horn neurons by endogenously released opioids

    Song, Bingbing; Marvizón, Juan Carlos G.


    To evaluate the effect of peptidases on μ-opioid receptor (MOR) activation by endogenous opioids, we measured MOR-1 internalization in rat spinal cord slices. A mixture of inhibitors of aminopeptidases (amastatin), dipeptidyl carboxypeptidase (captopril), and neutral endopeptidase (phosphoramidon) dramatically increased the potencies of Leu-enkephalin and dynorphin A to produce MOR-1 internalization, and also enhanced the effects of Met-enkephalin and α-neoendorphin, but not endomorphins or β...

  8. Stress intensity factors and crack opening areas for axial through cracks in hollow cylinders under internal pressure loading

    Ehlers, R.


    For a linear-elastic cylinder with an axial through crack subject to internal pressure loading, stress intensity factors and crack opening areas were calculated by the finite element method. Wall thickness and crack length were varied for constant mean radius of the cylinder, thus varying the shell parameter lambda with 2.5 release rate for a semi-infinite crack is finite, a simple interpolation formula is given that retains the proper asymptotic behaviour for very long and very short cracks. Crack opening areas are given and compared to an approximate analytical formula from the literature. Some general limitations of the validity of the present results, particularly the required minimum lengths of the cylinder, are discussed.

  9. The Role of Internalized Stereotyping, Parental Pressure, and Parental Support on Asian Americans' Choice of College Major

    Shen, Frances C.


    The author explored the relationship between internalized stereotyping, parental pressure, and parental support on major choices among 315 Asian American undergraduate and graduate students. Results indicated that parental support, but not parental pressure, toward certain majors was associated with more stereotypical major choices. In addition,…

  10. The Role of Internalized Stereotyping, Parental Pressure, and Parental Support on Asian Americans' Choice of College Major

    Shen, Frances C.


    The author explored the relationship between internalized stereotyping, parental pressure, and parental support on major choices among 315 Asian American undergraduate and graduate students. Results indicated that parental support, but not parental pressure, toward certain majors was associated with more stereotypical major choices. In addition,…

  11. Competition between Bending and Internal Pressure Governs the Mechanics of Fluid Nanovesicles.

    Vorselen, Daan; MacKintosh, Fred C; Roos, Wouter H; Wuite, Gijs J L


    Nanovesicles (∼100 nm) are ubiquitous in cell biology and an important vector for drug delivery. Mechanical properties of vesicles are known to influence cellular uptake, but the mechanism by which deformation dynamics affect internalization is poorly understood. This is partly due to the fact that experimental studies of the mechanics of such vesicles remain challenging, particularly at the nanometer scale where appropriate theoretical models have also been lacking. Here, we probe the mechanical properties of nanoscale liposomes using atomic force microscopy (AFM) indentation. The mechanical response of the nanovesicles shows initial linear behavior and subsequent flattening corresponding to inward tether formation. We derive a quantitative model, including the competing effects of internal pressure and membrane bending, that corresponds well to these experimental observations. Our results are consistent with a bending modulus of the lipid bilayer of ∼14kbT. Surprisingly, we find that vesicle stiffness is pressure dominated for adherent vesicles under physiological conditions. Our experimental method and quantitative theory represents a robust approach to study the mechanics of nanoscale vesicles, which are abundant in biology, as well as being of interest for the rational design of liposomal vectors for drug delivery.

  12. Experimental determination of radiated internal wave power without pressure field data

    Lee, Frank M; Swinney, Harry L; Morrison, P J


    We present a method to determine, using only velocity field data, the time-averaged energy flux $\\left$ and total radiated power $P$ for two-dimensional internal gravity waves. Both $\\left$ and $P$ are determined from expressions involving only a scalar function, the stream function $\\psi$. We test the method using data from a direct numerical simulation for tidal flow of a stratified fluid past a knife edge. The results for the radiated internal wave power given by the stream function method agree to within 0.5% with results obtained using pressure and velocity data from the numerical simulation. The results for the radiated power computed from the stream function agree well with power computed from the velocity and pressure if the starting point for the stream function computation is on a solid boundary, but if a boundary point is not available, care must be taken to choose an appropriate starting point. We also test the stream function method by applying it to laboratory data for tidal flow past a knife ed...

  13. On the phase between pressure and heat release fluctuations for propane/hydrogen flames and its role in mode transitions

    Hong, Seunghyuck


    This paper presents an experimental investigation into mode-transitions observed in a 50-kW, atmospheric pressure, backward-facing step combustor burning lean premixed C3H8/H2 fuel mixtures over a range of equivalence ratios, fuel compositions and preheat temperatures. The combustor exhibits distinct acoustic response and dynamic flame shape (collectively referred to as "dynamic modes") depending on the operating conditions. We simultaneously measure the dynamic pressure and flame chemiluminescence to examine the phase between pressure (p\\') and heat release fluctuations (q\\') in the observed dynamic modes. Results show that the heat release is in phase with the pressure oscillations (θqp≈0) at the onset of a dynamic mode, while as the operating conditions change within the mode, the phase grows until it reaches a critical value θqp=θc, at which the combustor switches to another dynamic mode. According to the classical Rayleigh criterion, this critical phase (θc) should be π/2, whereas our data show that the transition occurs well below this value. A linear acoustic energy balance shows that this critical phase marks the point where acoustic losses across the system boundaries equal the energy addition from the combustion process to the acoustic field. Based on the extended Rayleigh criterion in which the acoustic energy fluxes through the system boundaries as well as the typical Rayleigh source term (p\\'q\\') are included, we derive an extended Rayleigh index defined as Re=θqp/θc, which varies between 0 and 1. This index, plotted against a density-weighted strained consumption speed, indicates that the impact of the operating parameters on the dynamic mode selection of the combustor collapses onto a family of curves, which quantify the state of the combustor within a dynamic mode. At Re=0, the combustor enters a mode, and switches to another as Re approaches 1. The results provide a metric for quantifying the instability margins of fuel

  14. Hydrostatic pressure activates ATP-sensitive K+ channels in lung epithelium by ATP release through pannexin and connexin hemichannels.

    Richter, Katrin; Kiefer, Kevin P; Grzesik, Benno A; Clauss, Wolfgang G; Fronius, Martin


    Lungs of air-breathing vertebrates are constantly exposed to mechanical forces and therefore are suitable for investigation of mechanotransduction processes in nonexcitable cells and tissues. Freshly dissected Xenopus laevis lungs were used for transepithelial short-circuit current (ISC) recordings and were exposed to increased hydrostatic pressure (HP; 5 cm fluid column, modified Ussing chamber). I(SC) values obtained under HP (I(5cm)) were normalized to values before HP (I(0cm)) application (I(5cm)/I(0cm)). Under control conditions, HP decreased I(SC) (I(5cm)/I(0cm)=0.84; n=68; Plung. These data show an activation of KATP in pulmonary epithelial cells in response to HP that is induced by ATP release through mechanosensitive pannexin and connexin hemichannels. These findings represent a novel mechanism of mechanotransduction in nonexcitable cells.

  15. Wave-Induced Pressure Under an Internal Solitary Wave and Its Impact at the Bed

    Rivera, Gustavo; Diamesis, Peter; Jenkins, James; Berzi, Diego


    The bottom boundary layer (BBL) under a mode-1 internal solitary wave (ISW) of depression propagating against an oncoming model barotropic current is examined using 2-D direct numerical simulation based on a spectral multidomain penalty method model. Particular emphasis is placed on the diffusion into the bed of the pressure field driven by the wake and any near-bed instabilities produced under specific conditions. To this end, a spectral nodal Galerkin approach is used for solving the diffusion equation for the wave-induced pressure. At sufficiently high ISW amplitude, the BBL undergoes a global instability which produces intermittent vortex shedding from within the separation bubble in the lee of the wave. The interplay between the bottom shear stress field and pressure perturbations during vortex ejection events and the subsequent evolution of the vortices is examined. The potential for bed failure upon the passage of the ISW trough and implications for resuspension of bottom particulate matter are both discussed in the context of specific sediment transport models.

  16. Novel atmospheric pressure plasma device releasing atomic hydrogen: reduction of microbial-contaminants and OH radicals in the air

    Nojima, Hideo; Park, Rae-Eun; Kwon, Jun-Hyoun; Suh, Inseon; Jeon, Junsang; Ha, Eunju; On, Hyeon-Ki; Kim, Hye-Ryung; Choi, Kyoung Hui; Lee, Kwang-Hee; Seong, Baik-Lin; Jung, Hoon; Kang, Shin Jung; Namba, Shinichi; Takiyama, Ken


    A novel atmospheric pressure plasma device releasing atomic hydrogen has been developed. This device has specific properties such as (1) deactivation of airborne microbial-contaminants, (2) neutralization of indoor OH radicals and (3) being harmless to the human body. It consists of a ceramic plate as a positive ion generation electrode and a needle-shaped electrode as an electron emission electrode. Release of atomic hydrogen from the device has been investigated by the spectroscopic method. Optical emission of atomic hydrogen probably due to recombination of positive ions, H+(H2O)n, generated from the ceramic plate electrode and electrons emitted from the needle-shaped electrode have been clearly observed in the He gas (including water vapour) environment. The efficacy of the device to reduce airborne concentrations of influenza virus, bacteria, mould fungi and allergens has been evaluated. 99.6% of airborne influenza virus has been deactivated with the operation of the device compared with the control test in a 1 m3 chamber after 60 min. The neutralization of the OH radical has been investigated by spectroscopic and biological methods. A remarkable reduction of the OH radical in the air by operation of the device has been observed by laser-induced fluorescence spectroscopy. The cell protection effects of the device against OH radicals in the air have been observed. Furthermore, the side effects have been checked by animal experiments. The harmlessness of the device has been confirmed.

  17. International Space Station Science Information for Public Release on the NASA Web Portal

    Robinson, Julie A.; Tate, Judy M.


    This document contains some of the descriptions of payload and experiment related to life support and habitation. These describe experiments that have or are scheduled to fly on the International Space Station. There are instructions, and descriptions of the fields that make up the database. The document is arranged in alphabetical order by the Payload

  18. On anisotropy and internal pressure errors in numerical ocean models and processes near the shelf edge

    Thiem, Oeyvind A.


    In this thesis the focus has been on anisotropy, internal pressure errors and shelf edge/slope processes. Anisotropy is a common problem in ocean models. Especially where a rectangular grid is used to discretize the horizontal. Selecting a horizontal grid, which reduces the anisotropy, will therefore probably be important when new ocean models are being developed. Hexagonal grid discretization in the horizontal has the desired property of reducing anisotropy, and therefore this grid should be considered as a reasonable choice for new ocean models. In sigma coordinate models internal pressure errors occur in areas with steep topography. In the second paper in this thesis, it is shown that the internal pressure errors depend on the grid orientation. It is further shown that the erroneous velocities in the sea mount test case of Beckmann and Haidvogel (1993) can be reduced significantly by first computing the internal pressure gradients in both the original and a coordinate system where the axis are rotated 45 degrees to the original. Then a normalized weighted linear combination of the two estimates is used as the internal pressure gradients in the simulation. A following up paper where this method is used on a real ocean should be performed to investigate how well this method performs in domains with irregular topography. In such an experiment the boundary should be closed and the initial velocities set to zero. The occurring currents should then be compared with a corresponding experiment, where the initial pressure gradients are computed in the original grid only. In the third and fourth paper the focus is on the use of BOM in along shelf barotropic flow. First the generation of eddies is investigated. This is done in the third paper and two simulations are performed. The first simulation is a barotropic simulation, and the second is a two layer simulation. The results from both simulations show development of eddies, but the strength of the eddies depend on the

  19. Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement.

    Flack, John M; Sica, Domenic A; Bakris, George; Brown, Angela L; Ferdinand, Keith C; Grimm, Richard H; Hall, W Dallas; Jones, Wendell E; Kountz, David S; Lea, Janice P; Nasser, Samar; Nesbitt, Shawna D; Saunders, Elijah; Scisney-Matlock, Margaret; Jamerson, Kenneth A


    Since the first International Society on Hypertension in Blacks consensus statement on the "Management of High Blood Pressure in African American" in 2003, data from additional clinical trials have become available. We reviewed hypertension and cardiovascular disease prevention and treatment guidelines, pharmacological hypertension clinical end point trials, and blood pressure-lowering trials in blacks. Selected trials without significant black representation were considered. In this update, blacks with hypertension are divided into 2 risk strata, primary prevention, where elevated blood pressure without target organ damage, preclinical cardiovascular disease, or overt cardiovascular disease for whom blood pressure consistently blood pressure with target organ damage, preclinical cardiovascular disease, and/or a history of cardiovascular disease, for whom blood pressure consistently blood pressure is ≤10 mm Hg above target levels, monotherapy with a diuretic or calcium channel blocker is preferred. When blood pressure is >15/10 mm Hg above target, 2-drug therapy is recommended, with either a calcium channel blocker plus a renin-angiotensin system blocker or, alternatively, in edematous and/or volume-overload states, with a thiazide diuretic plus a renin-angiotensin system blocker. Effective multidrug therapeutic combinations through 4 drugs are described. Comprehensive lifestyle modifications should be initiated in blacks when blood pressure is ≥115/75 mm Hg. The updated International Society on Hypertension in Blacks consensus statement on hypertension management in blacks lowers the minimum target blood pressure level for the lowest-risk blacks, emphasizes effective multidrug regimens, and de-emphasizes monotherapy.

  20. Structural Analysis of Helios Filament-Wound Tanks Subjected to Internal Pressure and Cooling

    Ko, William L


    A finite-element stress analysis is performed on Helios filament-wound hydrogen tanks to examine the stress field and effect of end dome geometry on the stress field. Each tank is composed of a central circular cylindrical section with either geodesic or hemispherical end domes, which have metallic polar bosses. The tanks are subjected to combined and separate internal pressure and temperature loading conditions, and the stress contributions of each loading component are examined. The tank-wall-polar-boss interfacial meridional tensile stress in the hemispherical dome is found to be approximately 27 percent lower than that in the geodesic dome. The effects of both material anisotropy and the aluminum lining on the intensities of tensile meridional stress at the tank-wall-polar-boss bonding interface are examined.

  1. A nonlinear analysis of infinitely long graphite-epoxy cylindrical panels loaded with internal pressure

    Boitnott, R. L.; Johnson, E. R.; Starnes, J. H., Jr.


    The structural response of internally pressurized composite cylindrical panels, representative of a transport aircraft's fuselage skins, is predicted by means of a one-dimensional, geometrically nonlinear analysis. An analytical study is conducted for the response of 4-, 8-, and 16-ply graphite/epoxy skins. The results obtained indicate that the response is geometrically nonlinear, and that a boundary layer with a severe bending gradient exists at the panel edges. The importance of through-the-thickness shearing deformations in the bending boundary layer is illustrated through comparison of analyses based on Kirchhoff-Love and shear deformation theories. Numerical results for the bending boundary layer lengths of the different panels are presented, and two bending boundary layers are predicted with the shear deformation theory.




    In preparation for the eventual decommissioning of the High Flux Beam Reactor after the permanent removal of its fuel elements from the Brookhaven National Laboratory, both measurements and calculations of the decay gamma-ray dose rate have been performed for the reactor pressure vessel and vessel internal structures which included the upper and lower thermal shields, the transition plate, and the control rod blades. The measurements were made using Red Perspex{trademark} polymethyl methacrylate high-level film dosimeters, a Radcal ''peanut'' ion chamber, and Eberline's high-range ion chamber. To compare with measured gamma-ray dose rate, the Monte Carlo MCNP code and geometric progressive Microshield code were used to model the gamma transport and dose buildup.

  3. Dynamic neck development in a polymer tube under internal pressure loading

    Lindgreen, Britta; Tvergaard, Viggo; Needleman, Alan


    and a short wave length imperfection. After some thinning down at the necks, the mode of deformation switches to neck propagation along the circumference of the tube. A case is shown in which the necks have propagated along the entire tube wall, so that network locking in the polymer results in high stiffness......The initiation and growth of necks in polymer tubes subjected to rapidly increasing internal pressure is analyzed numerically. Plane strain conditions are assumed to prevail in the axial direction. The polymer is characterized by a finite strain elastic-viscoplastic constitutive relation...... and the calculations are carried out using a dynamic finite element program. Numerical results for neck development are illustrated and discussed for tubes of various thicknesses. The sensitivity to the wave number of the thickness imperfections is studied with a focus on comparing a long wave length imperfection...

  4. Probabilistic Internal Pressure Capacity Evaluation of Prestressed Concrete Containment Buildings using Bonded Tendons

    Hahm, Dea Gi; Choi, In Kil; Seo, Jeong Moon; Chon, Young Sun; Kim, Min Kyu [KAERI, Daejeon (Korea, Republic of)


    In this research, an assessment method of the internal pressure fragility of the CANDU type containment buildings is developed. The uncertainties of the performance of the containment buildings, material properties and tendon characteristics are referred from the in-service inspection reports of Wolsung Unit 1. The containment buildings are modeled as a three-dimensional finite elements with considering the major opening and penetrations. A new method to evaluate the probabilistic fragility of the massive structural system is proposed. The fragility curves of the target containment building are presented with respect to the failure modes and reliability levels. The center of wall is reveled as the most weak structural component of the containment building in the sense of the rupture and catastrophic rupture failure modes

  5. Sociocultural pressures, thin-ideal internalization, self-objectification, and body dissatisfaction: could feminist beliefs be a moderating factor?

    Myers, Taryn A; Crowther, Janis H


    Theory and research suggest that sociocultural pressures, thin-ideal internalization, and self-objectification are associated with body dissatisfaction, while feminist beliefs may serve a protective function. This research examined thin-ideal internalization and self-objectification as mediators and feminist beliefs as a moderator in the relationship between sociocultural pressures to meet the thin-ideal and body dissatisfaction. Female undergraduate volunteers (N=195) completed self-report measures assessing sociocultural influences, feminist beliefs, thin-ideal internalization, self-objectification, and body dissatisfaction. Multisample structural equation modeling showed that feminist beliefs moderate the relationship between media awareness and thin-ideal internalization, but not the relationship between social influence and thin-ideal internalization. Research and clinical implications of these findings are discussed.

  6. Control Rod Drive Mechanism Installed in the Internal of Reactor Pressure Vessel

    Choi, M. H.; Choi, S.; Park, J. S.; Lee, J. S.; Kim, D. O.; Hur, N. S.; Hur, H.; Yu, J. Y


    This report describes the review results and important technologies related to the in-vessel type control rod drive mechanism. Generally, most of the CRDMs used in the PWR are attached outside of the reactor pressure vessel, and the pernetration of the vessel head can not avoid. However, in-vessel type CRDMs, which are installed inside the reactor vessel, can eliminate the possibility of rod ejection accidents and the penetration of the vessel head, and provide a compact design of the reactor vessel and containment. There are two kinds of in-vessel type CRDM concerning the driving force-driven by a driving motor and by a hydraulic force. Motor driven CRDMs have been mainly investigated in Japan(MRX, IMR, DRX, next generation BWR etc.), and developed the key components such as a canned motor, an integrated rod position indicator, a separating ball-nut and a ball bearing that can operate under the water conditions of a high temperature and pressure. The concept of hydraulically driven CRDMs have been first reported by KWU and Siemens for KWU 200 reactor, and Argentina(CAREM) and China(NHR-5, NHR-200) have been developed the internal CRDM with the piston and cylinder of slightly different geometries. These systems are driven by the hydraulic force which is produced by pumps outside of the reactor vessel and transmitted through a pipe penetrating the reactor vessel, and needs complicated control and piping systems including pumps, valves and pipes etc.. IRIS has been recently decided the internal CRDMs as the reference design, and an analytical and experimental investigations of the hydraulic drive concept are performed by POLIMI in Italy. Also, a small French company, MP98 has been developed a new type of control rods, called 'liquid control rods', where reactivity is controlled by the movement of a liquid absorber in a manometer type device.

  7. Tailoring International Pressure Ulcer Prevention Guidelines for Nigeria: A Knowledge Translation Study Protocol

    Rose Ekama Ilesanmi


    Full Text Available Background: The 2014 International Pressure Ulcer Prevention (PUP Clinical Practice Guidelines (CPG provides the most current evidence based strategies to prevent Pressure Ulcer (PU. The evidence upon which these guidelines have been developed has predominantly been generated from research conducted in developed countries. Some of these guidelines may not be feasible in developing countries due to structural and resource issues; therefore there is a need to adapt these guidelines to the context thus making it culturally acceptable. Aim: To present a protocol detailing the tailoring of international PUPCPG into a care bundle for the Nigerian context. Methods: Guided by the Knowledge to Action (KTA framework, a two phased study will be undertaken. In Phase 1, the Delphi technique with stakeholder leaders will be used to review the current PUPCPG, identifying core strategies that are feasible to be adopted in Nigeria. These core strategies will become components of a PUP care bundle. In Phase 2, key stakeholder interviews will be used to identify the barriers, facilitators and potential implementation strategies to promote uptake of the PUP care bundle. Results: A PUP care bundle, with three to eight components is expected to be developed from Phase 1. Implementation strategies to promote adoption of the PUP care bundle into clinical practice in selected Nigerian hospitals, is expected to result from Phase 2. Engagement of key stakeholders and consumers in the project should promote successful implementation and translate into better patient care. Conclusion: Using KTA, a knowledge translation framework, to guide the implementation of PUPCPG will enhance the likelihood of successful adoption in clinical practice. In implementing a PUP care bundle, developing countries face a number of challenges such as the feasibility of its components and the required resources.

  8. Patient release criteria following radioactive iodine-131 treatment in the light of international practice: where does South Africa fit in?

    Mongane, Modisenyane S; Rae, William I D


    The release from hospital of patients treated with radioactive iodine-131 (I) remains a controversial issue as a result of the range of guidelines implemented by national regulatory bodies responsible for radiation protection in various countries worldwide. The aim of this study was to review and analyse the literature on patient release criteria (PRC) applied internationally in an attempt to achieve a justifiable approach to setting equivalent criteria in South Africa. In 2016, the South African Department of Health, Directorate: Radiation Control added conditions (numbers 50 and 90), to licences to use radioactive nuclides. These conditions state that patients must be hospitalized when the dose rate at 1 m is above 25 μSv/h, or more than 555 MBq of iodine-131 was administered to the patient. However, these criteria do not consider patients' socioeconomic conditions. A literature survey was carried out of articles detailing PRC from high-income countries as well as those in the middle-income and lower-income groups. Socioeconomic conditions within countries were determined using the International Monetary Fund lists of gross domestic product. The results from the literature have shown that in setting PRC, several countries have considered the socioeconomic conditions prevailing in their countries to achieve harmony between public protection and cost associated with hospitalization. The South African authority conditions must be seen in the context of the approach followed by other countries. Considering the international context, a justifiable, and potentially implementable, guideline or policy for improving individualized and more caring patient management is advocated.

  9. Line Emission from Radiation-Pressurized HII Regions I: Internal Structure and Line Ratios

    Yeh, Sherry C C; Krumholz, Mark R; Matzner, Christopher D; Tielens, Alexander G G M


    The emission line ratios [OIII]5007/H-beta and [NII]6584/H-alpha have been adopted as an empirical way to distinguish between the fundamentally different mechanisms of ionization in emission-line galaxies. However, detailed interpretation of these diagnostics requires calculations of the internal structure of the emitting HII regions, and these calculations depend on the assumptions one makes about the relative importance of radiation pressure and stellar winds. In this paper we construct a grid of quasi-static HII region models to explore how choices about these parameters alter HII regions' emission line ratios. We find that, when radiation pressure is included in our models, HII regions reach a saturation point beyond which further increases in the luminosity of the driving stars does not produce any further increase in effective ionization parameter, and thus does not yield any further alteration in an HII region's line ratio. We also show that, if stellar winds are assumed to be strong, the maximum possi...

  10. Simultaneous high-speed internal and external flow measurements for a high-pressure diesel nozzle

    Purwar, Harsh; Méès, Loïc; Rozé, Claude; Blaisot, Jean-Bernard; Michard, Marc; Maligne, David


    We present an extensive experimental study focused on understanding the impact of cavitation in a high-pressure diesel nozzle on the macroscopic properties of fuel spray. Several high-speed videos of the liquid flow through a transparent, asymmetric cylindrical nozzle with a single orifice (phi = 0.35 mm) are recorded along with the videos of the resulting spray in the near-nozzle region, issued with an injection pressure of 300 bar at a frame-rate of 75 kHz. The high-repetition images of the internal flow are then used to estimate the onset of cavitation inside the transparent nozzle and the probability of development of cavitation in different regions of the nozzle with an average estimate of the amount of cavitation with time. On the other hand, recorded spray images are used to study spray penetration, cone-angles and velocity from the start of fuel injection. A novel approach is proposed for the measurement of perturbations that occur in form of big liquid structures along the spray boundary.

  11. International Space Station (ISS) Bacterial Filter Elements (BFEs): Filter Efficiency and Pressure Testing of Returned Units

    Green, Robert D.; Agui, Juan H.; Vijayakumar, R.


    The air revitalization system aboard the International Space Station (ISS) provides the vital function of maintaining a clean cabin environment for the crew and the hardware. This becomes a serious challenge in pressurized space compartments since no outside air ventilation is possible, and a larger particulate load is imposed on the filtration system due to lack of sedimentation due to the microgravity environment in Low Earth Orbit (LEO). The ISS Environmental Control and Life Support (ECLS) system architecture in the U.S. Segment uses a distributed particulate filtration approach consisting of traditional High-Efficiency Particulate Adsorption (HEPA) media filters deployed at multiple locations in each U.S. Segment module; these filters are referred to as Bacterial Filter Elements, or BFEs. These filters see a replacement interval, as part of maintenance, of 2-5 years dependent on location in the ISS. In this work, we present particulate removal efficiency, pressure drop, and leak test results for a sample set of 8 BFEs returned from the ISS after filter replacement. The results can potentially be utilized by the ISS Program to ascertain whether the present replacement interval can be maintained or extended to balance the on-ground filter inventory with extension of the lifetime of ISS beyond 2024. These results can also provide meaningful guidance for particulate filter designs under consideration for future deep space exploration missions.

  12. Subject-specific biomechanics of trunk: musculoskeletal scaling, internal loads and intradiscal pressure estimation.

    Ghezelbash, F; Shirazi-Adl, A; Arjmand, N; El-Ouaaid, Z; Plamondon, A


    Development of a subject-specific computational musculoskeletal trunk model (accounting for age, sex, body weight and body height), estimation of muscle forces and internal loads as well as subsequent validation by comparison with measured intradiscal pressure in various lifting tasks are novel, important and challenging. The objective of the present study is twofold. First, it aims to update and personalize the passive and active structures in an existing musculoskeletal kinematics-driven finite element model. The scaling scheme used an existing imaging database and biomechanical principles to adjust muscle geometries/cross-sectional-areas and passive joint geometry/properties in accordance with subjects' sex, age, body weight and body height. Second, using predictions of a detailed passive finite element model of the ligamentous lumbar spine, a novel nonlinear regression equation was proposed that relates the intradiscal pressure (IDP) at the L4-L5 disc to its compression force and intersegmental flexion rotation. Predicted IDPs and muscle activities of the personalized models under various tasks are found in good-to-excellent agreement with reported measurements. Results indicate the importance of personal parameters when computing muscle forces and spinal loads especially at larger trunk flexion angles as minor changes in individual parameters yielded up to 30 % differences in spinal forces. For more accurate subject-specific estimation of spinal loads and muscle activities, such a comprehensive trunk model should be used that accounts for subject's personalized features on active musculature and passive spinal structure.

  13. International scientific consensus on medical plantar pressure measurement devices: technical requirements and performance

    Claudia Giacomozzi


    Full Text Available BACKGROUND: Since 2006, the Italian National Institute of Health (ISS has been conducting independent scientific activities to standardize the technical assessment of plantar pressure measurement devices (PMDs. MATERIAL AND METHODS: On the basis of the ISS results, in 2010 the Pedobarographic Group of the International Foot and Ankle Biomechanics community (i-FAB-PG promoted a consensus activity about the main technical requirements for the appropriate use of PMDs. The activity relied on a moodlebased on-line forum, documents exchange, discussions, reviews, meetings and a final survey. RESULTS: The participation of clinical and technical researchers, users, and manufacturers, contributed to the delivery of the hereby reported recommendations which specifically regard Medical PMDs in the form of platforms. CONCLUSIONS: The i-FAB-PG community reached overall agreement on the recommendations, with a few minor objections which are reported and commented in the document. RELEVANCE: The present document, the highest result achievable within a small scientific community, will hopefully represent the starting point of the wider process of establishing official international guidelines or standards, within scientific communities and standardization organizations.

  14. Disruption of Pseudomonas putida by high pressure homogenization: a comparison of the predictive capacity of three process models for the efficient release of arginine deiminase.

    Patil, Mahesh D; Patel, Gopal; Surywanshi, Balaji; Shaikh, Naeem; Garg, Prabha; Chisti, Yusuf; Banerjee, Uttam Chand


    Disruption of Pseudomonas putida KT2440 by high-pressure homogenization in a French press is discussed for the release of arginine deiminase (ADI). The enzyme release response of the disruption process was modelled for the experimental factors of biomass concentration in the broth being disrupted, the homogenization pressure and the number of passes of the cell slurry through the homogenizer. For the same data, the response surface method (RSM), the artificial neural network (ANN) and the support vector machine (SVM) models were compared for their ability to predict the performance parameters of the cell disruption. The ANN model proved to be best for predicting the ADI release. The fractional disruption of the cells was best modelled by the RSM. The fraction of the cells disrupted depended mainly on the operating pressure of the homogenizer. The concentration of the biomass in the slurry was the most influential factor in determining the total protein release. Nearly 27 U/mL of ADI was released within a single pass from slurry with a biomass concentration of 260 g/L at an operating pressure of 510 bar. Using a biomass concentration of 100 g/L, the ADI release by French press was 2.7-fold greater than in a conventional high-speed bead mill. In the French press, the total protein release was 5.8-fold more than in the bead mill. The statistical analysis of the completely unseen data exhibited ANN and SVM modelling as proficient alternatives to RSM for the prediction and generalization of the cell disruption process in French press.

  15. Internal energy deposition and ion fragmentation in atmospheric-pressure mid-infrared laser ablation electrospray ionization.

    Nemes, Peter; Huang, Hehua; Vertes, Akos


    Mid-infrared laser ablation of water-rich targets at the maximum of the 2.94 μm absorption band is a two-step process initiated by phase explosion followed by recoil pressure induced material ejection. Particulates and/or droplets ejected by this high temperature high pressure process can be ionized for mass spectrometry by charged droplets from an electrospray. In order to gauge the internal energy introduced in this laser ablation electrospray ionization (LAESI®) process, we apply the survival yield method and compare the results with electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI). The results indicate that LAESI yields ions with internal energies indistinguishable from those produced by ESI. This finding is consistent with the recoil pressure induced ejection of low micrometre droplets that does not significantly change the internal energy of solute molecules.

  16. A Non-Invasive Ultrasonic Urinary Bladder Internal Pressure Monitoring Technique: Its Theoretical Foundation and Feasibility Test

    Choi, Min Joo; Kang, Gwan Suk [Jeju National University, Jeju (Korea, Republic of); Lee, Kang Il [Department of Physics, Kangwon National University, Chuncheon (Korea, Republic of)


    A new approach was proposed in this article, named, a non-invasive ultrasonic method to monitor the urinary bladder internal pressure which can resolve the shortcomings of the existing methods. The proposed method makes use of acoustic cavitation. It is based on a physical phenomenon that an extracorporeal high intensity focused ultrasonic pulse generates bubbles inside the urinary bladder and the dynamic properties of the bubbles are related to the urinary bladder internal pressure. The article presents the theoretical foundation for the proposed technique and verifies its feasibility with preliminary experimental data. The suggested ultrasonic urinary bladder internal pressure monitoring method is non-invasive and can be used any time regardless of sex and age.

  17. Influence of lower body negative pressure release on soleus H reflex, respiratory sensations and reflexes in human subjects.

    Anand, Ashima; Raj, Hans; Gupta, Uday A; Srivastava, Niraj


    Using a physiological model of acutely increasing venous return into the lungs, i.e. by applying and then releasing lower body negative pressure (LBNP) to mimic the natural stimulus of juxtapulmonary capillary (J) or pulmonary C fibre receptors, produced an immediate and significant reduction in the amplitude of the Hoffman (H) reflex by 81±4% (P=0.001) in a majority of subjects 70% (n=5). Accompanying this was a notable change in the respiratory pattern with tidal volume (V(T)) increasing in all subjects from (mean) 0.462±.038 to 0.777±.061l/min (P=0.001) and the respiratory rate (F(R)) in 40% from 14±1 to 24±0.8 breaths/min. A feeling of pressure in throat, upper chest was reported by all and a shortness of breath-by 70% of the subjects. These were similar in nature to the respiratory sensations felt with threshold doses of intravenous lobeline, a well-established chemical stimulant of J receptors. All effects lasted for 15-20s and within a minute the parameters resumed their earlier control values. In animals, respiratory augmentation and locomotion inhibition are well-established reflexes of J receptors - this simultaneous though transitory reduction in H reflex amplitude reflecting change in the excitability of the motoneurone pool and appearance of respiratory effects, is the first demonstration in human subjects of the two reflexes appearing in response to a sudden increase in pulmonary blood flow that mimics the natural stimulus of these receptors. Copyright 2010 Elsevier B.V. All rights reserved.

  18. Stresses and Displacements in Steel-Lined Pressure Tunnels and Shafts in Anisotropic Rock Under Quasi-Static Internal Water Pressure

    Pachoud, Alexandre J.; Schleiss, Anton J.


    Steel-lined pressure tunnels and shafts are constructed to convey water from reservoirs to hydroelectric power plants. They are multilayer structures made of a steel liner, a cracked backfill concrete layer, a cracked or loosened near-field rock zone and a sound far-field rock zone. Designers often assume isotropic behavior of the far-field rock, considering the most unfavorable rock mass elastic modulus measured in situ, and a quasi-static internal water pressure. Such a conventional model is thus axisymmetrical and has an analytical solution for stresses and displacements. However, rock masses often have an anisotropic behavior and such isotropic assumption is usually conservative in terms of quasi-static maximum stresses in the steel liner. In this work, the stresses and displacements in steel-lined pressure tunnels and shafts in anisotropic rock mass are studied by means of the finite element method. A quasi-static internal water pressure is considered. The materials are considered linear elastic, and tied contact is assumed between the layers. The constitutive models used for the rock mass and the cracked layers are presented and the practical ranges of variation of the parameters are discussed. An extensive systematic parametric study is performed and stresses and displacements in the steel liner and in the far-field rock mass are presented. Finally, correction factors are derived to be included in the axisymmetrical solution which allow a rapid estimate of the maximum stresses in the steel liners of pressure tunnels and shafts in anisotropic rock.

  19. Radionuclides release from re-irradiated fuel under high temperature and pressure conditions. Gamma-ray measurements of VEGA-5 test

    Hidaka, Akihide; Kudo, Tamotsu; Nakamura, Takehiko; Kanazawa, Toru; Kiuchi, Toshio; Uetsuka, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment


    The VEGA (Verification Experiments of radionuclides Gas/Aerosol release) program is being performed at JAERI to clarify mechanisms of radionuclides release from irradiated fuel during severe accidents and to improve source term predictability. The fifth VEGA-5 test was conducted in January 2002 to confirm the reproducibility of decrease in cesium release under elevated pressure that was observed in the VEGA-2 test and to investigate the release behavior of short-life radionuclides. The PWR fuel of 47 GWd/tU after about 8.2 years of cooling was re-irradiated at Nuclear Safety Research Reactor (NSRR) for 8 hours before the heat-up test. After that, the two pellets of 10.9 g without cladding were heated up to about 2,900 K at 1.0 MPa under the inert He condition. The experiment reconfirmed the decrease in cesium release rate under the elevated pressure. The release data on short-life radionuclides such as Ru-103, Ba-140 and Xe-133 that have never been observed in the previous VEGA tests without re-irradiation was obtained using the {gamma} ray measurement. (author)

  20. FOREWORD: The 4th CCM International Conference on Pressure Metrology from Ultra-High Vacuum to Very High Pressures (10-9 Pa to 109 Pa)

    Legras, Jean-Claude; Jousten, Karl; Severn, Ian


    The fourth CCM (Consultative Committee for Mass and related quantities) International Conference on Pressure Metrology from Ultra-High Vacuum to Very High Pressures (10-9 Pa to 109 Pa) was held at the Institute of Physics in London from 19-21 April 2005. The event, which was organized by the Low, Medium and High Pressure working groups of the CCM, was attended by in excess of one hundred participants with representatives from five continents and every regional metrology organization. The purpose of this conference is to review all the work that is devoted to the highest quality of pressure measurement by primary standards as well as the dissemination of the pressure scale. A total of 52 papers were presented orally, and 26 as posters, in sessions that covered the following topics: Latest scientific advances in pressure and vacuum metrology Innovative transfer standards, advanced sensors and new instrument development Primary (top-level) measurement standards International and regional key comparisons New approaches to calibration It is interesting the note that since the third conference in 1999 the pressure range covered has increased by two orders of magnitude to 109 Pa, to take into account more exacting scientific and industrial demands for traceable vacuum measurement. A further feature of the conference was the increased range of instrumentation and techniques used in the realization and potential realization of pressure standards. Seton Bennett, Director of International Metrology at the National Physical Laboratory, opened the conference and Andrew Wallard, Director of the Bureau International des Poids et Mesures (BIPM), gave the keynote address which described the implementation of the mutual recognition arrangement and the resulting removal of metrological barriers to international trade. Many experts have contributed significant amounts of their time to organize the event and to review the submitted papers. Thanks are due to all of these people

  1. 78 FR 1735 - Airworthiness Directives; Honeywell International Inc. Air Data Pressure Transducers


    ... measurement error in the pressure transducer used in various air data systems, which translates into air data... using the pressure measurements. The primary concern is the impact on the air data system and the... pressure measurement error in the pressure transducer used in various air data systems, which translates...

  2. Complete Maps for the Internal Oxidation of Ideal Ternary Alloys Forming Insoluble Oxides under High Oxidant Pressures



    This paper presents an analysis of the conditions of stability of the different forms of internal oxidation of ideal ternary A-B-C alloys, where A is the most noble and C the most reactive component, forming insoluble oxide and exposed to high pressures of a single oxidant. The treatment, based on an extension to ternary alloys of Wagner's criterion for the transition from internal to external oxidation in binary alloys, allows to predict the existence of three different forms of internal oxidation. In fact, in addition to the most common kinds of internal attack, involving the coupled internal oxidation of B+C beneath external AO scales and the internal oxidation of C beneath external BO scales, a third mode, involving the internal oxidation of C beneath external scales composed of mixtures of AO+BO, becomes also possible under special conditions. A combination of the boundary conditions for the existence of these different types of internal oxidation allows to predict three different kinds of complete maps for the internal oxidation in these systems, one of which involves only two modes, while the other two involve all the three possible modes of internal oxidation.

  3. Evaluation of a Composite Sandwich Fuselage Side Panel with Damage and Subjected to Internal Pressure

    Rouse, Marshall; Ambur, Damodar R.; Bodine, Jerry; Dopker, Bernhard


    The results from an experimental and analytical study of a composite sandwich fuselage side panel for a transport aircraft are presented. The panel has two window cutouts and three frames, and has been evaluated with internal pressure loads that generate biaxial tension loading conditions. Design limit load and design ultimate load tests have been performed on the graphite-epoxy sandwich panel with the middle frame removed to demonstrate the suitability of this two-frame design for supporting the prescribed biaxial loading conditions with twice the initial frame spacing of 20 inches. The two-frame panel was damaged by cutting a notch that originates at the edge of a cutout and extends in the panel hoop direction through the window-belt area. This panel with a notch was tested in a combined-load condition to demonstrate the structural damage tolerance at the design limit load condition. The two panel configurations successfully satisfied all design load requirements in the experimental part of the study, and the three-frame and two-frame panel responses are fully explained by the analysis results. The results of this study suggest that there is potential for using sandwich structural concepts with greater than the usual 20-in.-wide frame spacing to further reduce aircraft fuselage structural weight.

  4. Response of Composite Fuselage Sandwich Side Panels Subjected to Internal Pressure and Axial Tension

    Rouse, Marshall; Ambur, Damodar R.; Dopker, Bernard; Shah, Bharat


    The results from an experimental and analytical study of two composite sandwich fuselage side panels for a transport aircraft are presented. Each panel has two window cutouts and three frames and utilizes a distinctly different structural concept. These panels have been evaluated with internal pressure loads that generate biaxial tension loading conditions. Design limit load and design ultimate load tests have been performed on both panels. One of the sandwich panels was tested with the middle frame removed to demonstrate the suitability of this two-frame design for supporting the prescribed biaxial loading conditions with twice the initial frame spacing of 20 inches. A damage tolerance study was conducted on the two-frame panel by cutting a notch in the panel that originates at the edge of a cutout and extends in the panel hoop direction through the window-belt area. This panel with a notch was tested in a combined-load condition to demonstrate the structural damage tolerance at the design limit load condition. Both the sandwich panel designs successfully satisfied all desired load requirements in the experimental part of the study, and experimental results from the two-frame panel with and without damage are fully explained by the analytical results. The results of this study suggest that there is potential for using sandwich structural concepts with greater than the usual 20-in. wide frame spacing to further reduce aircraft fuselage structural weight.

  5. Release of alkali salts and coal volatiles affecting internal components in fluidized bed combustion systems

    Arias del Campo, E.


    Full Text Available In spite of the potential advantages of atmospheric fluidized bed systems, experience has proved that, under certain environments and operating conditions, a given material employed for internal components could lead to catastrophic events. In this study, an attempt is made to establish material selection and operational criteria that optimize performance and availability based on theoretical considerations of the bed hydrodynamics, thermodynamics and combustion process. The theoretical results may indicate that, for high-volatile coals with particle diameters (dc of 1-3 mm and sand particle size (ds of 0.674 mm, a considerable proportion of alkali chlorides may be transferred into the freeboard region of fluidized bed combustors as vapor phase, at bed temperatures (Tb < 840 °C, excess air (XSA ≤ 20 %, static bed height (Hs ≤ 0.2 m and fluidizing velocity (Uo < 1 m/s. Under these operating conditions, a high alkali deposition may be expected to occur in heat exchange tubes located above the bed. Conversely, when the combustors operate at Tb > 890 °C and XSA > 30 %, a high oxidation rate of the in-bed tubes may be present. Nevertheless, for these higher Tb values and XSA < 10 %, corrosion attack of metallic components, via sulfidation, would occur since the excessive gas-phase combustion within the bed induced a local oxygen depletion.

    A pesar de las ventajas potenciales de los sistemas atmosféricos de lecho fluidizado, la experiencia ha demostrado que, bajo ciertas atmósferas y condiciones de operación, un material que se emplea como componente interno podría experimentar una falla y conducir a eventos catastróficos. En este estudio, se intenta establecer un criterio tanto operativo como de selección del material que permita optimizar su disponibilidad y funcionalidad basados en consideraciones teóricas de la hidrodinámica del lecho, la termodin

  6. Effect of drug physicochemical properties on drug release and their relationship with drug skin permeation behaviors in hydroxyl pressure sensitive adhesive.

    Liu, Chao; Quan, Peng; Fang, Liang


    The aim of this study was to investigate the influence of drug physicochemical properties on drug release behaviors and their relationship with skin permeation behaviors, which provided transdermal enhancement strategies for the design of transdermal drug delivery system. Six model drugs with different physicochemical properties were selected and hydroxyl pressure sensitive adhesive (PSA) was synthesized. Horizontal diffusion cell was used to evaluate drug release and skin permeation behaviors. The relationship between physicochemical properties and release behaviors was conducted with regression analysis. Release behavior of 0.25% drug loading was linear related with polar surface area, which represented the hydrogen bond. Release behavior of 2.0% drug loading was dependent on the polarizability and log P, which represented dipole-dipole interaction and lipophilicity, respectively. According to the results of Fourier transform infrared spectroscopy, it was inferred that hydrogen bond was limited in controlling release of drug due to the limited quantity of bonding site, thus dipole-dipole interaction and log P became dominate control factors. Combining the drug release study and drug skin permeation study, it was concluded that drugs with different physicochemical properties should be applied with different transdermal enhancement strategies, which was useful for the design of transdermal drug delivery system. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Changes in Doppler waveforms can predict pressure reduction across internal carotid artery stenoses

    Sillesen, H; Schroeder, T


    perfusion pressure. Forty-nine patients were examined consecutively with ultrasound Doppler prior to carotid endarterectomy. Pulsatility index (PI), pulse rise-time (RT), and systolic width (SW) were related to angiographic degree of stenosis and the ratio of distal ICA blood pressure to common carotid...... artery (CCA) blood pressure (ICA/CCA pressure ratio). The latter was determined during surgery. All three waveform parameters were significantly correlated with the ICA/CCA pressure ratio when calculated from the mean frequency curve (p less than 0.001). A reduction in ICA pressure of 20% could...

  8. Pharmacokinetics and Paw Withdrawal Pressure in Female Guinea Pigs (Cavia porcellus) Treated with Sustained-Release Buprenorphine and Buprenorphine Hydrochloride.

    Smith, Brian J; Wegenast, Daniel J; Hansen, Ryan J; Hess, Ann M; Kendall, Lon V


    Providing appropriate analgesia is essential in minimizing pain and maintaining optimal animal care and welfare in laboratory animals. Guinea pigs are common animal models in biomedical research, often requiring analgesic support. Here we evaluated the pharmacokinetics and efficacy of a sustained-release formulation of buprenorphine (Bup-SR) in this species. Guinea pigs (n = 7 each group) received either Bup-HCl (0.05 mg/kg BID for 3 d) or Bup-SR (0.3 mg/kg once). Plasma collection and measurement of paw-withdrawal pressure (PWP) was conducted at 0, 1, 3, 6, 12, 26, 48, and 72 h after treatment. Plasma levels of Bup-HCl peaked at 2331 pg/mL at 1 h after administration and declined to 165 pg/mL by 12 h. Plasma concentrations of Bup-SR peaked at 1344 pg/mL at 26 h after administration and declined to 429 pg/mL by 48 h. The PWP of the Bup-HCltreated guinea pigs peaked at 674 g at 1 h and declined to 402 g at 6 h, whereas that of Bup-SRtreated guinea pigs at 1 h was 361 g, 555 g at 6 h (significantly higher than that after Bup-HCl), and peaked at 680 g at 12 h. The PWP of both treatments was similar from 24 to 72 h and ranged from 348 to 450 g. The plasma concentration and PWP showed good correlation. These results suggest that Bup-SR provides consistent analgesia equivalent to that of Bup-HCl for a prolonged period of time and that Bup-SR is an alternative method of analgesia in guinea pigs.

  9. Piston slap induced pressure fluctuation in the water coolant passage of an internal combustion engine

    Ohta, Kazuhide; Wang, Xiaoyu; Saeki, Atsushi


    Liner cavitation is caused by water pressure fluctuation in the water coolant passage (WCP). When the negative pressure falls below the saturated vapor pressure, the impulsive pressure following the implosion of cavitation bubbles causes cavitation erosion of the wet cylinder liner surface. The present work establishes a numerical model for structural-acoustic coupling between the crankcase and the acoustic field in the WCP considering their dynamic characteristics. The coupling effect is evaluated through mutual interaction terms that are calculated from the mode shapes of the acoustic field and of the crankcase vibration on the boundary. Water pressure fluctuations in the WCP under the action of piston slap forces are predicted and the contributions of the uncoupled mode shapes of the crankcase and the acoustic field to the pressure waveform are analyzed. The influence of sound speed variations on the water pressure response is discussed, as well as the pressure on the thrust sides of the four cylinders.

  10. Self-compassion as a moderator of thinness-related pressures' associations with thin-ideal internalization and disordered eating.

    Tylka, Tracy L; Russell, Hannah L; Neal, Ashley A


    During situations that threaten personal adequacy, people high in self-compassion are kind and caring toward themselves, mindful of their distress, and recognize that being imperfect is part of the human experience. Therefore, self-compassion may offset certain disorders (e.g., eating disorders) associated with environmental threats (e.g., thinness-related pressures). In this cross-sectional study, we explored self-compassion's associations with threats involving thinness-related pressures (from friends, family, partners, and media), thin-ideal internalization, and disordered eating among an online sample of 435 U.S. community women. Findings indicated that self-compassion buffered the links from media thinness-related pressure to disordered eating and thin-ideal internalization. Furthermore, higher self-compassion was directly associated with fewer perceived thinness-related pressures, lower thin-ideal internalization, and lower disordered eating. Collectively, these findings add to the growing conceptualization of self-compassion as beneficial to eating behavior and help justify pursuing rigorous longitudinal and clinical examinations of self-compassion as a protective factor of disordered eating. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Application of FOX-TEK sensors to measure strains in steel pipe with wall thinning defects under internal pressure

    Tennyson, R.C.; Lin, W.; Doiron, A. [Natural Resources Canada, Ottawa, ON (Canada)


    A project was undertaken as part of the ISPIR program to investigate the application of fiber optic sensing to monitor pipelines. This report discussed the application of FOX-TEK (FT) sensors to measure strains in steel pipe with wall thinning defects under internal pressure. Sensor installation and pipe test results were both discussed. Several illustrations were offered, including the geometry of pipes with internal defects and location of FT sensors; smoothing of the pipe surface prior to bonding sensors; close-up views of 2 FT sensors bonded over defect areas of the steel pipe; an overview of steel pipe with 3 FT sensors; and an internal pressure test of steel pipe with 4 FT sensors connected to an FTI 3300 instrument. FT sensor strain results were plotted for 2 different sized cutouts and a finite element analysis was conducted to calculate the circumferential strain distribution for 24 inch and 4 inch cutouts, with and without the weld seams present. It was concluded that the FT sensors can accurately detect the hoop strains for uniform wall sections, circumferential defect areas and large regions of wall thinning for a pipe under internal pressure. 1 tab., 8 figs.

  12. The Gaia-ESO Survey: the chemical structure of the Galactic discs from the first internal data release

    Mikolaitis, Š; Recio-Blanco, A; de Laverny, P; Prieto, C Allende; Kordopatis, G; Tautvaišiene, G; Romano, D; Gilmore, G; Randich, S; Feltzing, S; Micela, G; Vallenari, A; Alfaro, E J; Bensby, T; Bragaglia, A; Flaccomio, E; Lanzafame, A C; Pancino, E; Smiljanic, R; Bergemann, M; Carraro, G; Costado, M T; Damiani, F; Hourihane, A; Jofré, P; Lardo, C; Magrini, L; Maiorca, E; Morbidelli, L; Sbordone, L; Sousa, S G; Worley, C C; Zaggia, S


    Most high-resolution spectroscopic studies of the Galactic discs were mostly confined to objects in the solar vicinity. Here we aim at enlarging the volume in which individual chemical abundances are used to characterise both discs, using the first internal data release of the Gaia-ESO survey. We derive and discuss the abundances of eight elements (Mg, Al, Si, Ca, Ti, Fe, Cr, Ni, and Y). The trends of these elemental abundances with iron are very similar to those in the solar neighbourhood. We find a natural division between alpha-rich and alpha-poor stars, best seen in the bimodality of the [Mg/M] distributions in bins of metallicity, which we attribute to thick- and thin-disc sequences, respectively. With the possible exception of Al, the observed dispersion around the trends is well described by the expected errors, leaving little room for astrophysical dispersion. Using previously derived distances from Recio-Blanco et al. (2014b), we further find that the thick-disc is more extended vertically and is mor...

  13. Transcutaneous pressure at which the internal jugular vein is collapsed on ultrasonic imaging predicts easiness of the venous puncture.

    Joo, Woo Jin; Fukui, Michihiko; Kooguchi, Kunihiko; Sakaguchi, Masahiro; Shinzato, Taiichi


    Even though we use ultrasound guidance for central venous puncture, we sometimes experience difficulties. We infer that in such cases the vein is collapsed and that the transcutaneous ultrasound probe pressure at which the vein is collapsed (P (tc)) may predict the easiness of the venous puncture. We measured P (tc) and the diameter of the internal jugular vein in 47 adult patients in our ICU. After successful puncture, we also measured venous pressure (P (v)). The patients were divided into two groups based on the number of puncture attempts: ≥3 attempts constituted the "difficult group" and venous collapsibility and vertical diameter determine difficulty in performing venous puncture.

  14. Perceived social pressures and the internalization of the mesomorphic ideal: The role of drive for muscularity and autonomy in physically active men.

    Edwards, Christian; Tod, David; Molnar, Gyozo; Markland, David


    We examined if there were both direct and indirect relationships (via the drive for muscularity) between the perceived pressure to be muscular and internalization of the mesomorphic ideal, and if autonomy moderates these relationships in physically active men. A sample of 330 men, who were undergraduate students studying sport, completed the Behavioral Regulation in Exercise Questionnaire-2, the Mesomorphic Ideal Internalization subscale of the revised male version Sociocultural Attitudes Toward Appearance Questionnaire, the Perceived Sociocultural Pressure Scale-Modified, and the Drive for Muscularity Scale Attitudes subscale. Perceived pressure predicted internalization directly, and indirectly through the drive for muscularity. The direct relationship between pressure and internalization was weaker under higher levels of autonomy. The indirect path, via drive for muscularity, was stronger under higher levels of autonomy. These results provide insights into why men vary in the degree to which they internalize pressure to develop a mesomorphic ideal, supporting further examination of autonomy.

  15. Internal ballistics of recoilless high-low pressure guns using hepta-tubular powders

    M. C. Gupta


    Full Text Available In this paper, the theory of recoilless high-low pressure guns has been discussed by taking the form function and the results have been applied to the case of hepta-tubular powders. The results for high-low pressure guns follow as a particular case.

  16. Blood Pressure in Young Adults Born at Very Low Birth Weight: Adults Born Preterm International Collaboration

    Hovi, P.; Vohr, B.; Ment, L.R.; Doyle, L.W.; McGarvey, L.; Morrison, K.M.; Evensen, K.A.I.; Pal, S. van der; Grunau, R.E.; Brubakk, A.M.; Andersson, S.; Saigal, S.; Kajantie, E.


    Adults born preterm at very low birth weight (VLBW; <1500 g) have higher blood pressure than those born at term. It is not known whether all VLBW adults are at risk or whether higher blood pressure could be attributed to some of the specific conditions underlying or accompanying preterm birth. To

  17. Blood Pressure in Young Adults Born at Very Low Birth Weight: Adults Born Preterm International Collaboration

    Hovi, P.; Vohr, B.; Ment, L.R.; Doyle, L.W.; McGarvey, L.; Morrison, K.M.; Evensen, K.A.I.; Pal, S. van der; Grunau, R.E.; Brubakk, A.M.; Andersson, S.; Saigal, S.; Kajantie, E.


    Adults born preterm at very low birth weight (VLBW; <1500 g) have higher blood pressure than those born at term. It is not known whether all VLBW adults are at risk or whether higher blood pressure could be attributed to some of the specific conditions underlying or accompanying preterm birth. To id

  18. Comparison of Airway Pressure Release Ventilation to Conventional Mechanical Ventilation in the Early Management of Smoke Inhalation Injury in Swine


    acute respiratory distress syndrome developed ( PaO2 /FIO2 ratio ), plateau pressures were limited to ន cm H2O. Six uninjured pigs received...conventional mechanical ventilation for 48 hrs and served as time controls. Changes in PaO2 /FIO2 ratio, tidal volume, respiratory rate, mean airway pressure...plateau pressure, and hemody- namic variables were recorded. Survival was assessed using Kaplan- Meier analysis. PaO2 /FIO2 ratio was lower in airway

  19. Dependence of macrophage superoxide release on the pulse amplitude of an applied pressure regime: a potential factor at the soft tissue-implant interface.

    Shin, Hainsworth Y; Frechette, Danielle M; Rohner, Nathan; Zhang, Xiaoyan; Puleo, David A; Bjursten, Lars M


    Failure of soft tissue implants has been largely attributed to the influence of biomaterial surface properties on the foreign body response, but some implant complications, e.g. macrophage accumulation and necrosis, are still not effectively addressed with surface treatments to minimize deleterious biomaterial effects. We explored an alternative explanation for implant failure, linking biocompatibility with implant micromotion-induced pressure fluctuations at the tissue-biomaterial interface. For this purpose, we used a custom in vitro system to characterize the effects of pressure fluctuations on the activity of macrophages, the predominant cells at a healing implant site. Initially, we quantified superoxide production by HL60-derived macrophage-like cells under several different pressure regimes with means of 5-40 mmHg, amplitudes of 0-15 mmHg and frequencies of 0-1.5 Hz. All pressure regimes tested elicited significantly (p superoxide production by macrophage-like cells relative to parallel controls. Notably, pressure-sensitive reductions in superoxide release correlated (r(2)  = 0.74; p superoxide production and cell viability, we also explored the influence of cyclic pressure on macrophage numbers and death. Compared to controls, adherent macrophage-like cells exposed to 7.5/2.5 mmHg cyclic pressures for 6 h exhibited significantly (p superoxide dismutase. Collectively, our results suggest that pressure pulses are a putative regulator of macrophage adhesion via a superoxide-related effect. Pressure fluctuations, e.g. due to implant micromotion, may, therefore, potentially modulate macrophage-dependent wound healing.

  20. Ramifications of structural deformations on collapse loads of critically cracked pipe bends under in-plane bending and internal pressure

    Sasidharan, Sumesh; Arunachalam, Veerappan; Subramaniam, Shanmugam [Dept. of Mechanical Engineering, National Institute of Technology, Tiruchirappalli (India)


    Finite-element analysis based on elastic-perfectly plastic material was conducted to examine the influence of structural deformations on collapse loads of circumferential through-wall critically cracked 90 .deg. pipe bends undergoing in-plane closing bending and internal pressure. The critical crack is defined for a through-wall circumferential crack at the extrados with a subtended angle below which there is no weakening effect on collapse moment of elbows subjected to in-plane closing bending. Elliptical and semioval cross sections were postulated at the bend regions and compared. Twice-elastic-slope method was utilized to obtain the collapse loads. Structural deformations, namely, ovality and thinning, were each varied from 0% to 20% in steps of 5% and the normalized internal pressure was varied from 0.2 to 0.6. Results indicate that elliptic cross sections were suitable for pipe ratios 5 and 10, whereas for pipe ratio 20, semioval cross sections gave satisfactory solutions. The effect of ovality on collapse loads is significant, although it cancelled out at a certain value of applied internal pressure. Thinning had a negligible effect on collapse loads of bends with crack geometries considered.

  1. Research on the internal pressure behavior of metal gas distribution pipelines with different types of tubing defects

    Filip Stefan Mihai


    Full Text Available The paper aims to approach an important subject related to natural gas distribution networks which, depending on the expansion of the localities, are composed of intercommunicating pipes, pressure reducing stations and branch connections fittings. The urban networks are the most complex ones and the rural areas networks are the simplest. However, irrespective of their installation, they must meet the safety operating requirements as much as possible. According to standards, all these components must be tight and pressure resistant. In this regard, we intend to approach a very important issue related to the behavior of the tubular steel material showing corrosion and/or material defects, and to the internal stress caused by the gas pressure on the walls of the tubing material.

  2. Experimental study of heat transfer of ultra-supercritical pressure water in vertical upward internally ribbed tube

    Wang Weishu; Chen Tingkuan; Luo Yushan; Gu Hongfang; Yin Fei


    Under ultra-supercritical pressure, the heat transfer characteristics of water in vertical upward 4-head internally ribbed tubes with a diameter of 28.65mm and thickness of 8mm were experimentally studied.The experiments were performed at P=25~34MPa,G=450~1800kg/(m2·s)and q=200~600kW/m2. The results show that the pressure has only a moderate effect on the heat transfer of ultra-supercritical water when the water temperature is below the pseudocritical point. Sharp rise of the wall temperature near the pesudocritical region occurs earlier at a higher pressure. Increasing the mass velocity improves the heat transfer with a much stronger effect below the pesudocritical point than that above the pesudocritical point. For given pressure and mass velocity, the inner wall heat flux also shows a significant effect on the inner wall temperature, with a higher inner wall heat flux leading to a higher inner wall temperature. Increasing of inner wall heat flux leads to an early occurrence of sharp rise of the wall temperature. Correlations of heat transfer coefficients are also presented for vertical upward internally ribbed tubes.

  3. Prognosis of white-coat and masked hypertension: International Database of HOme blood pressure in relation to Cardiovascular Outcome.

    Stergiou, George S; Asayama, Kei; Thijs, Lutgarde; Kollias, Anastasios; Niiranen, Teemu J; Hozawa, Atsushi; Boggia, José; Johansson, Jouni K; Ohkubo, Takayoshi; Tsuji, Ichiro; Jula, Antti M; Imai, Yutaka; Staessen, Jan A


    Home blood pressure monitoring is useful in detecting white-coat and masked hypertension and is recommended for patients with suspected or treated hypertension. The prognostic significance of white-coat and masked hypertension detected by home measurement was investigated in 6458 participants from 5 populations enrolled in the International Database of HOme blood pressure in relation to Cardiovascular Outcomes. During a median follow-up of 8.3 years, 714 fatal plus nonfatal cardiovascular events occurred. Among untreated subjects (n=5007), cardiovascular risk was higher in those with white-coat hypertension (adjusted hazard ratio 1.42; 95% CI [1.06-1.91]; P=0.02), masked hypertension (1.55; 95% CI [1.12-2.14]; Phypertension (2.13; 95% CI [1.66-2.73]; Phigh office and low home blood pressure (white-coat) and treated controlled subjects (low office and home blood pressure; 1.16; 95% CI [0.79-1.72]; P=0.45). However, treated subjects with masked hypertension (low office and high home blood pressure; 1.76; 95% CI [1.23-2.53]; P=0.002) and uncontrolled hypertension (high office and home blood pressure; 1.40; 95% CI [1.02-1.94]; P=0.04) had higher cardiovascular risk than treated controlled patients. In conclusion, white-coat hypertension assessed by home measurements is a cardiovascular risk factor in untreated but not in treated subjects probably because the latter receive effective treatment on the basis of their elevated office blood pressure. In contrast, masked uncontrolled hypertension is associated with increased cardiovascular risk in both untreated and treated patients, who are probably undertreated because of their low office blood pressure.

  4. Certain hormonal profiles of postpartum anestrus jersey crossbred cows treated with controlled internal drug release and ovsynch protocol

    Dayanidhi Jena


    Full Text Available Aim: The study was conducted to determine the serum levels of certain hormones in post-partum anestrus cows following treatment with controlled internal drug release (CIDR and Ovsynch protocol. Materials and Methods: A total of 30 postpartum anestrus cows were divided into three equal groups after thorough gynecoclinical examination. The Group 1 animals received an intravaginal progesterone device on day 0 and 2 ml of prostaglandin F2α (PGF2α on day of CIDR removal (7th day, Group 2 cows were treated with ovsynch protocol (gonadotropinreleasing hormone [GnRH]-PGF2α-GnRH on day 0, 7 and 9, respectively, and Group 3 cows were supplemented with mineral mixture and treated as control. The serum estrogen, progesterone, triiodothyronine, and thyroxine concentration were estimated using enzyme-linked immunosorbent assay kit and absorbance was read at 450 nm with Perkin Elmer Wallac 1420 Microplate Reader. Results: There was a significant increase in progesterone level in Group 1 after withdrawal of CIDR as compared to other two groups. However, the estrogen assay revealed a greater concentration in Group 2 against Group 1 on day 7 of sampling. However, there was no significant difference for serum triiodothyronine (T3 and thyroxine (T4 irrespective of treatment protocols and days of sampling. Conclusion: Treatment with CIDR based progesterone therapy and drug combinations may affect the reproductive hormonal balance like estrogen and progesterone, which is inevitable for successful return to cyclicity and subsequent fertilization and conception. However, as far as serum T3 and T4 concentration concerned it may not give an astounding result.

  5. Characterization of endocrine events during the periestrous period in sheep after estrous synchronization with controlled internal drug release (CIDR) device.

    Van Cleeff, J; Karsch, F J; Padmanabhan, V


    The Controlled Internal Drug Releasing (CIDR) device is an intravaginal pessary containing progesterone (P4) designed for synchronizing estrus in ruminants. To date, there has been little information available on the timing, duration, and quality of the follicular phase after CIDR removal and how those characteristics compare with natural periovulatory endocrine events. The present communication relates the results of methods we used to characterize the endocrine events that followed CIDR synchronization. Breeding-season ewes were given an injection (10 mg) of Lutalyse (PGF2 alpha), and then studied during three consecutive estrous cycles, beginning in the luteal phase after the estrus induced by PGF2 alpha. Cycle 1 estrus was synchronized with 1 CIDR (Type G) inserted for 8 d beginning 10 d after PGF2 alpha. Cycles 2 and 3 were synchronized with two CIDRs for 8 d beginning 10 d after previous CIDR removal. Cycle 1 estrous behavior and serum gonadotropins showed a follicular phase (the interval from CIDR withdrawal to gonadotropin surge [surge] peak) of 38.2 +/- 1.5 hr. Two CIDRs lengthened the interval to 46.2 +/- 1.5 hr (P synchronization concentrated surges within a 24-hr period in 92% of the ewes in Cycles 1 and 2. Cycles 3 ewes were euthanized at estimated luteal, early follicular, late follicular, LH surge, and secondary FSH rise timepoints. Endocrine data and ovaries showed that 88% of the ewes synchronized with two CIDRs were in the predicted stage of the estrous cycle. These data demonstrate that the CIDR device applied during the luteal phase effectively synchronizes estrus and results in a CIDR removal-to-surge interval of similar length to a natural follicular phase.

  6. Blood Pressure in Young Adults Born at Very Low Birth Weight: Adults Born Preterm International Collaboration.

    Hovi, Petteri; Vohr, Betty; Ment, Laura R; Doyle, Lex W; McGarvey, Lorcan; Morrison, Katherine M; Evensen, Kari Anne I; van der Pal, Sylvia; Grunau, Ruth E; Brubakk, Ann-Mari; Andersson, Sture; Saigal, Saroj; Kajantie, Eero


    Adults born preterm at very low birth weight (VLBW; blood pressure than those born at term. It is not known whether all VLBW adults are at risk or whether higher blood pressure could be attributed to some of the specific conditions underlying or accompanying preterm birth. To identify possible risk or protective factors, we combined individual-level data from 9 cohorts that measured blood pressure in young adults born at VLBW or with a more stringent birth weight criterion. In the absence of major heterogeneity, we performed linear regression analysis in our pooled sample of 1571 adults born at VLBW and 777 controls. Adults born at VLBW had 3.4 mm Hg (95% confidence interval, 2.2-4.6) higher systolic and 2.1 mm Hg (95% confidence interval, 1.3-3.0) higher diastolic pressure, with adjustment for age, sex, and cohort. The difference in systolic pressure was present in men (1.8 mm Hg; 95% confidence interval, 0.1-3.5) but was stronger in women (4.7 mm Hg; 95% confidence interval, 3.2-6.3). Among the VLBW group, blood pressure was unrelated to gestational age, maternal smoking, multiple pregnancy, retinopathy of prematurity, or bronchopulmonary dysplasia. Blood pressure was higher than that of controls among VLBW adults unexposed to maternal preeclampsia. Among those exposed, it was even higher, especially if born appropriate for gestational age. In conclusion, although female sex and maternal preeclampsia are additional risk factors, the risk of higher blood pressure is not limited to any etiologic subgroup of VLBW adults, arguing for vigilance in early detection of high blood pressure in all these individuals. © 2016 American Heart Association, Inc.

  7. Validation of the Oregon Scientific BPU 330 for self-monitoring of blood pressure according to the International Protocol

    Li Li


    Full Text Available Li Li1, XinYu Zhang1, ChunHong Yan1, QingXiang Liang21Biomedical Engineering Lab, Faculty of Information Engineering, ShenZhen University, ShenZhen, China; 2Bao An People’s Hospital, ShenZhen, ChinaObjective: Extensive marketing of devices for self-measurement of blood pressure has created a need for purchasers to be able to satisfy themselves that such devices have been evaluated according to agreed criteria. The Oregon Scientific BPU 330 blood pressure monitor is an electronic device for upper arm measurement. This study assessed the accuracy of the Oregon Scientific BPU 330 blood pressure monitor according to the International Protocol by the Working Group on Blood Pressure Monitoring of the European Society of Hypertension for validation of blood pressure measuring devices.Method: 52 participants over 30 years of age were studied in the validation. Nine blood pressure measurements were taken alternately with a mercury sphygmomanometer by two observers, and by the supervisor, using the BPU 330 device. A total of 33 participants were selected for the analysis. The validation was divided into two phases. Phase 1 included 15 participants. If the device passed phase 1, 18 more participants were included. The 99 pairs of measurements were compared according to the International Protocol. The device was given a pass/fail recommendation based on its accuracy compared with the mercury standard (within 5, 10, and 15 mmHg, as well as the number met in the ranges specified by the International Protocol.Results: The mean and standard deviation of the difference between the mean of the observers and the BPU 330 device were 1.7 ± 4.7 mmHg and 2.8 ± 3.9 mmHg for systolic blood pressure (SBP and diastolic blood pressure (DBP, respectively. In phase 1, the device passed with a total of 33, 43, and 44 SBP readings; 38, 44, and 45 DBP readings were within 5, 10, and 15 mmHg, respectively. In phase 2.1, 81, 95, and 96 for SBP, and 83, 95, and 98 for DBP

  8. Preparation of porous poly(trimethylene carbonate structures for controlled release applications using high pressure CO2

    Nalawade, S.P.; Hennink, W.E.; Westerman, D.; Feijen, J.; Sam, A.P.; Leeke, G.; Santos, R.C.D.; Grijpma, Dirk W.; Feijen, Jan


    Porous poly(trimethylene carbonate) structures can readily be prepared using high pressure CO2. Differences in CO2 solubility in the polymer matrix at the different processing temperatures and pressures lead to different pore morphologies upon depressurization. Furthermore, crystallization of the

  9. Preparation of porous poly(trimethylene carbonate) structures for controlled release applications using high pressure CO2

    Nalawade, S.P.; Westerman, D.; Leeke, G.; Santos, R.C.D.; Grijpma, D.W.; Feijen, J.


    Porous poly(trimethylene carbonate) structures can readily be prepared using high pressure CO2. Differences in CO2 solubility in the polymer matrix at the different processing temperatures and pressures lead to different pore morphologies upon depressurization. Furthermore, crystallization of the in

  10. Review of the International Atomic Energy Agency International database on reactor pressure vessel materials and US Nuclear Regulatory Commission/Oak Ridge National Laboratory embrittlement data base

    Wang, J.A.; Kam, F.B.K.


    The International Atomic Energy Agency (IAEA) has supported neutron radiation effects information exchange through meetings and conferences since the mid-1960s. Through an International Working Group on Reliability of Reactor Pressure Components, information exchange and research activities were fostered through the Coordinated Research Program (CRP) sponsored by the IAEA. The final CRP meeting was held in November 1993, where it was recommended that the IAEA coordinate the development of an International Database on Reactor Pressure Vessel Material (IDRPVM) as the first step in generating an International Database on Aging Management. The purpose of this study was to provide special technical assistance to the NRC in monitoring and evaluating the IAEA activities in developing the IAEA IDRPVM, and to compare the IDRPVM with the Nuclear Regulatory Commission (NRC) - Oak Ridge National Laboratory (ORNL) Power Reactor Embrittlement Data Base (PR-EDB) and provide recommendations for improving the PR-EDB. A first test version of the IDRPVM was distributed at the First Meeting of Liaison Officers to the IAEA IDRPVM, in November 1996. No power reactor surveillance data were included in this version; the testing data were mainly from CRP Phase III data. Therefore, because of insufficient data and a lack of power reactor surveillance data received from the IAEA IDRPVM, the comparison is made based only on the structure of the IDRPVM. In general, the IDRPVM and the EDB have very similar data structure and data format. One anticipates that because the IDRPVM data will be collected from so many different sources, quality assurance of the data will be a difficult task. The consistency of experimental test results will be an important issue. A very wide spectrum of material characteristics of RPV steels and irradiation environments exists among the various countries. Hence the development of embrittlement prediction models will be a formidable task. 4 refs., 2 figs., 4 tabs.


    LI Yang; LIU Jie; OUYANG Hua; DU Zhao-Hui


    This article presents the flow mechanism analysis and experimental study of a forward-skewed impeller and a radial impeller in low pressure axial fan. The forward-skewed blade was obtained by the optimization design of the radial blade and CFD technique. Measurement of the two blades was carried out in aerodynamic and aeroacoustic performance. Compared to the radial blade, the forward-skewed blade has demonstrated the improvements in efficiency, total pressure ratio, Stable Operating Range (SOR) and less aerodynamic noise. Detailed flow measurement and computation were performed for outlet flow field for investigating the responsible flow mechanisms. The results show the forward-skewed blade can cause a spanwise redistribution of flow toward the blade mid-span and reduce tip loading. This results in reduced significantly total pressure loss near hub and shroud endwall region, despite the slight increase of total pressure loss at mid-span.

  12. Microelectromechanical System-Based Internally Unpowered Leak-Pressure Sensor Project

    National Aeronautics and Space Administration — To address the NASA need for a miniature pressure-leak sensor, Physical Optics Corporation (POC) proposes to develop a new Microelectromechanical System-based...

  13. Analysis of Releasing Curve for High Pressure Chamber%高压容腔卸压曲线的研究

    任晓剑; 武晓凤; 姚平喜; 张晓俊


    提出了使油液以无冲击、振动和气蚀的最大动量变化量排出高压容腔的卸压思想。通过理论分析与公式推导,得到了卸压过程中高压容腔压力、卸压阀开口面积、卸压时间三者之间的关系。基于负载敏感原理,对卸压阀阀芯结构进行了初步设计,分析表明:此阀口可满足快速、无冲击卸压的要求。%A pressure relief method was proposed with which the high pressure fluid was discharged with maximum momentum variable quantity in less impact,less vibration and non-cavitation. By theoretical analysis and formula derivation,the relationships a-mong the pressure of chamber,the throttle area of pressure relief valve,the pressure relief time were obtained. Based on the load-sens-ing theory,the structure of pressure relief valve core was preliminarily designed. The result shows that the valve port can meet the pres-sure relief requirement of rapid,non-impact.

  14. The autocrine role of tryptase in pressure overload-induced mast cell activation, chymase release and cardiac fibrosis

    Jianping Li


    Results and conclusion: The results indicate the presence of PAR-2 on MCs and that tryptase inhibition and nedocromil prevented TAC-induced fibrosis and increases in MC density, activation, and chymase release. Tryptase also significantly increased chymase concentration in ventricular slice culture media, which was prevented by the tryptase inhibitor. Hydroxyproline concentration in culture media was significantly increased with tryptase incubation as compared to the control group and the tryptase group incubated with nafamostat mesilate or chymostatin. We conclude that tryptase contributes to TAC-induced cardiac fibrosis primarily via activation of MCs and the amplified release of chymase.

  15. Releases of whooping cranes to the Florida nonmigratory flock: a structured decision-making approach: report to the International Whooping Crane Recovery Team, September 22, 2008

    Moore, Clinton T.; Converse, Sarah J.; Folk, Martin J.; Boughton, Robin; Brooks, Bill; French, John B.; O'Meara, Timothy; Putnam, Michael; Rodgers, James; Spalding, Marilyn


    We used a structured decision-making approach to inform the decision of whether the Florida Fish and Wildlife Conservation Commission should request of the International Whooping Crane Recovery Team that additional whooping crane chicks be released into the Florida Non-Migratory Population (FNMP). Structured decision-making is an application of decision science that strives to produce transparent, replicable, and defensible decisions that recognize the appropriate roles of management policy and science in decision-making. We present a multi-objective decision framework, where management objectives include successful establishment of a whooping crane population in Florida, minimization of costs, positive public relations, information gain, and providing a supply of captive-reared birds to alternative crane release projects, such as the Eastern Migratory Population. We developed models to predict the outcome relative to each of these objectives under 29 different scenarios of the release methodology used from 1993 to 2004, including options of no further releases and variable numbers of releases per year over the next 5-30 years. In particular, we developed a detailed set of population projection models, which make substantially different predictions about the probability of successful establishment of the FNMP. We used expert elicitation to develop prior model weights (measures of confidence in population model predictions); the results of the population model weighting and modelaveraging exercise indicated that the probability of successful establishment of the FNMP ranged from 9% if no additional releases are made, to as high as 41% with additional releases. We also used expert elicitation to develop weights (relative values) on the set of identified objectives, and we then used a formal optimization technique for identifying the optimal decision, which considers the tradeoffs between objectives. The optimal decision was identified as release of 3 cohorts (24

  16. The Effects of a Chactoid Scorpion Venom and Its Purified Toxins on Rat Blood Pressure and Mast Cells Histamine Release


    The effect of the venom of the Chactoid family of scorpions on blood pressure was scantly investigated and was addressed in the present study using the venom of the Israeli scorpion, Scorpio maurus palmatus. Blood pressure in rats was monitored via cannulated femoral artery, while venom and toxins were introduced into femoral vein. Venom injection elicited a biphasic effect, expressed first by a fast and transient hypotensive response, which lasted up to 10 min, followed by a hypertensive res...

  17. Measurement of internal die pressure distributions during pultrusion of thermoplastic composites

    Fanucci, Jerome P.; Nolet, Stephen C.; Koppernaes, Christian; Kim, Young R.

    This paper describes the development and use of a thin, disposable pressure sensor designed specifically for monitoring pointwise through-the-thickness consolidation forces developed during composite processing. The unique postage stamp-sized sensor (11.1 mm diameter active gage area and 0.31 mm thickness) can be placed directly at points in or on a laminate where pressure data is desired. The sonsor's small dimensions and low cost permit it to be treated as a disposable item in aerospace and other composite fabrication applications. This paper will illustrate the use of the sensor as a means of measuring the pressures developed inside a die during the pultrusion of a graphite/ULTEM thermoplastic structure, as well as with other pultrusion processing examples.

  18. Impact of Dietary Acculturation on the Food Habits, Weight, Blood Pressure, and Fasting Blood Glucose Levels of International College Students.

    Almohanna, Amal; Conforti, Frank; Eigel, William; Barbeau, William


    This study was conducted to determine the impact of dietary acculturation on the health status of newly arrived international students at Virginia Tech in Fall 2010. Thirty-five international students, 18-36 years of age, completed the study. Data were collected at 3 different time periods (V1, V2, and V3) approximately 6 weeks apart. A food frequency- and dietary pattern-related questionnaire was administered and numerically coded responses were analyzed. Twenty-four-hour dietary recall data were also collected at V1, V2, and V3. Body weight, fasting blood glucose level, and blood pressure of study participants were also determined at each time period. Total sample population (TSP) had a significant increase in mean weight of 2.79 lb from visit 1 (V1) to visit 3 (V3) (p = .0082). Ten participants gained an average of 9.0 lb (participants who gained weight; n = 10). There was also an increase in the frequency of consumption of high-calorie American food items from V1 to V3. However, there were no significant changes in mean systolic blood pressure and mean fasting blood glucose was significantly lower at V3 than at V1. There was a gradual shift in the dietary patterns of international students towards the American diet. Dietary acculturation led to weight gain among some of the students, which may potentially have a negative impact on their health status if continued for longer time periods.

  19. Temporal links to performing under pressure in international soccer penalty shootouts

    Jordet, Geir; Hartman, Esther; Sigmundstad, Einar


    Objectives: This study examined the temporal characteristics of performing under pressure in a high-stakes real-world sport situation. Design: Behavior observation analyses were conducted of televised soccer games. Methods: Videos were obtained from all penalty shootouts ever held in three major int

  20. Temporal links to performing under pressure in international soccer penalty shootouts

    Jordet, Geir; Hartman, Esther; Sigmundstad, Einar


    Objectives: This study examined the temporal characteristics of performing under pressure in a high-stakes real-world sport situation. Design: Behavior observation analyses were conducted of televised soccer games. Methods: Videos were obtained from all penalty shootouts ever held in three major

  1. Investigation of the Unsteady Total Pressure Profile Corresponding to Counter-Rotating Vortices in an Internal Flow Application

    Gordon, Kathryn; Morris, Scott; Jemcov, Aleksandar; Cameron, Joshua


    The interaction of components in a compressible, internal flow often results in unsteady interactions between the wakes and moving blades. A prime example in which this flow feature is of interest is the interaction between the downstream rotor blades in a transonic axial compressor with the wake vortices shed from the upstream inlet guide vane (IGV). Previous work shows that a double row of counter-rotating vortices convects downstream into the rotor passage as a result of the rotor blade bow shock impinging on the IGV. The rotor-relative time-mean total pressure distribution has a region of high total pressure corresponding to the pathline of the vortices. The present work focuses on the relationship between the magnitude of the time-mean rotor-relative total pressure profile and the axial spacing between the IGV and the rotor. A survey of different axial gap sizes is performed in a two-dimensional computational study to obtain the sensitivity of the pressure profile amplitude to IGV-rotor axial spacing.

  2. A fluid-structure interaction model of the internal carotid and ophthalmic arteries for the noninvasive intracranial pressure measurement method.

    Misiulis, Edgaras; Džiugys, Algis; Navakas, Robertas; Striūgas, Nerijus


    Accurate and clinically safe measurements of intracranial pressure (ICP) are crucial for secondary brain damage prevention. There are two methods of ICP measurement: invasive and noninvasive. Invasive methods are clinically unsafe; therefore, safer noninvasive methods are being developed. One of the noninvasive ICP measurement methods implements the balance principle, which assumes that if the velocity of blood flow in both ophthalmic artery segments - the intracranial (IOA) and extracranial (EOA) - is equal, then the acting ICP on the IOA and the external pressure (Pe) on the EOA are also equal. To investigate the assumption of the balance principle, a generalized computational model incorporating a fluid-structure interaction (FSI) module was created and used to simulate noninvasive ICP measurement by accounting for the time-dependent behavior of the elastic internal carotid (ICA) and ophthalmic (OA) arteries and their interaction with pulsatile blood flow. It was found that the extra balance pressure term, which incorporates the hydrodynamic pressure drop between measurement points, must be added into the balance equation, and the corrections on a difference between the velocity of blood flow in the IOA and EOA must be made, due to a difference in the blood flow rate.

  3. Limit analysis of viscoplastic thick-walled cylinder and spherical shell under internal pressure using a strain gradient plasticity theory


    Plastic limit load of viscoplastic thick-walled cylinder and spherical shell subjected to internal pressure is investigated analytically using a strain gradient plastic-itv theory. As a result, the current solutions can capture the size effect at the micron scale. Numerical results show that the smaller the inner radius of the cylinder or spherical shell, the more significant the scale effects. Results also show that the size effect is more evident with increasing strain or strain-rate sensitivity index. The classical plastic-based solutions of the same problems are shown to be a special case of the present solution.

  4. Evaluation of wind-induced internal pressure in low-rise buildings: A multi scale experimental and numerical approach

    Tecle, Amanuel Sebhatu

    Hurricane is one of the most destructive and costly natural hazard to the built environment and its impact on low-rise buildings, particularity, is beyond acceptable. The major objective of this research was to perform a parametric evaluation of internal pressure (IP) for wind-resistant design of low-rise buildings and wind-driven natural ventilation applications. For this purpose, a multi-scale experimental, i.e. full-scale at Wall of Wind (WoW) and small-scale at Boundary Layer Wind Tunnel (BLWT), and a Computational Fluid Dynamics (CFD) approach was adopted. This provided new capability to assess wind pressures realistically on internal volumes ranging from small spaces formed between roof tiles and its deck to attic to room partitions. Effects of sudden breaching, existing dominant openings on building envelopes as well as compartmentalization of building interior on the IP were systematically investigated. Results of this research indicated: (i) for sudden breaching of dominant openings, the transient overshooting response was lower than the subsequent steady state peak IP and internal volume correction for low-wind-speed testing facilities was necessary. For example a building without volume correction experienced a response four times faster and exhibited 30--40% lower mean and peak IP; (ii) for existing openings, vent openings uniformly distributed along the roof alleviated, whereas one sided openings aggravated the IP; (iii) larger dominant openings exhibited a higher IP on the building envelope, and an off-center opening on the wall exhibited (30--40%) higher IP than center located openings; (iv) compartmentalization amplified the intensity of IP and; (v) significant underneath pressure was measured for field tiles, warranting its consideration during net pressure evaluations. The study aimed at wind driven natural ventilation indicated: (i) the IP due to cross ventilation was 1.5 to 2.5 times higher for Ainlet/Aoutlet>1 compared to cases where Ainlet

  5. Effects of metoclopramide and metoclopramide/dopamine on blood pressure and insulin release in normotensive, hypertensive, and type 2 diabetic subjects.

    Contreras, Freddy; Fouillioux, Christian; Lares, Mary; Bolívar, Hector; Hernández, Rafael Hernández; Velasco, Manuel; Cano, Raquel; Chacin, Maricarmen; Bermúdez, Valmore


    The objective is to determine cardiovascular and insulin release effects under metoclopramide (MTC) and dopamine (DA) infusion by using an acute comparative design with the intravenous infusion of both drugs. We evaluated 15 normal (normotensive and normoglycemic) subjects, 13 hypertensive, and 15 type 2 diabetic subjects. Subjects were submitted to an experimental design in which we first gave them a 0.9% saline solution for 30 minutes, and then administered MTC at 7.5 microg kg min through an intravenous infusion during a period of 30 minutes. Although subjects were receiving MTC, we added an intravenous infusion of DA at 1-3 microg kg min during 30 minutes. Blood pressure, heart rate, serum lipid profile, and insulin levels were measured. Sympathetic reactivity by the cold pressor test was also measured. In normotensive subjects, there was a systolic blood pressure and heart rate increase during MTC plus DA infusion. In subjects with diabetes mellitus there was a heart rate increase without changes in blood pressure during the MTC plus DA infusion period. In hypertensive subjects, MTC induced a significant decrease of systolic and diastolic blood pressure. During MTC plus DA period there was an increase of heart rate but no significant changes in blood pressure. During cold pressor test in both diabetic and hypertensive subjects, there were significant increases of both blood pressure and heart rate. Insulin serum levels increased in normotensive and hypertensive subjects but were attenuated in subjects with diabetes mellitus. We conclude that there is a pharmacologic interaction between MTC and DA, that the pressor effects of DA are due to activation to beta and alpha adrenergic receptors, and that the cardiovascular effects of DA in type 2 diabetic subjects are attenuated by a probable defect in sympathetic system and to endothelial dysfunction.

  6. Blood volume, blood pressure and total body sodium: internal signalling and output control

    Bie, P


    , and under experimental conditions, ABP is a powerful, independent controller of NaEx. Blood volume is a function of dietary salt intake; however, ABP is not, at least not in steady states. A transient increase in ABP after a step-up in sodium intake could provide a causal relationship between ABP......Total body sodium and arterial blood pressure (ABP) are mutually dependent variables regulated by complex control systems. This review addresses the role of ABP in the normal control of sodium excretion (NaEx), and the physiological control of renin secretion. NaEx is a pivotal determinant of ABP...... and the regulation of NaEx via a hypothetical integrative control system. However, recent data show that subtle sodium loading (simulating salty meals) causes robust natriuresis without changes in ABP. Changes in ABP are not necessary for natriuresis. Normal sodium excretion is not regulated by pressure. Plasma...

  7. Flow Control Device Evaluation for an Internal Flow with an Adverse Pressure Gradient

    Jenkins, Luther N.; Gorton, Susan Althoff; Anders, Scott G.


    The effectiveness of several active and passive devices to control flow in an adverse pressure gradient with secondary flows present was evaluated in the 15 Inch Low Speed Tunnel at NASA Langley Research Center. In this study, passive micro vortex generators, micro bumps, and piezoelectric synthetic jets were evaluated for their flow control characteristics using surface static pressures, flow visualization, and 3D Stereo Digital Particle Image Velocimetry. Data also were acquired for synthetic jet actuators in a zero flow environment. It was found that the micro vortex generator is very effective in controlling the flow environment for an adverse pressure gradient, even in the presence of secondary vortical flow. The mechanism by which the control is effected is a re-energization of the boundary layer through flow mixing. The piezoelectric synthetic jet actuators must have sufficient velocity output to produce strong longitudinal vortices if they are to be effective for flow control. The output of these devices in a laboratory or zero flow environment will be different than the output in a flow environment. In this investigation, the output was higher in the flow environment, but the stroke cycle in the flow did not indicate a positive inflow into the synthetic jet.

  8. Parental pressure and support toward Asian Americans' self-efficacy, outcome expectations, and interests in stereotypical occupations: Living up to parental expectations and internalized stereotyping as mediators.

    Shen, Frances C; Liao, Kelly Yu-Hsin; Abraham, W Todd; Weng, Chih-Yuan


    This study examined whether living up to parental expectations and internalized stereotyping (i.e., internalizing Asian American stereotypes) mediated the impact of parental pressure and support on occupational outcomes (i.e., self-efficacy, outcome expectations, and interests in stereotypical occupations) among 229 Asian American students from universities nationwide. Results indicated that living up to parental expectations and internalized stereotyping partially mediated the associations between parental pressure and these 3 occupational outcomes. In addition, living up to parental expectations fully mediated the associations between parental support and the 3 occupational outcomes, but internalized stereotyping did not. The results demonstrated the differential role of parental pressure and parental support as well as the mediating role of living up to parental expectations and internalized stereotyping in Asian Americans' occupational outcomes. Future research directions and clinical implications are discussed.

  9. Analytical solution for the pseudoelastic response of a shape memory alloy thick-walled cylinder under internal pressure

    Tabesh, M.; Liu, B.; Boyd, J. G.; Lagoudas, D. C.


    Analytical solutions are derived for the isothermal pseudoelastic response of a shape memory alloy (SMA) thick-walled cylinder subjected to internal pressure. The Tresca transformation criterion and linear hardening are used. Equations are given for the radial and circumferential stresses, transformation strains and radial displacement at various steps of loading and unloading. A structural pressure-temperature phase diagram is provided for the cylinder, analogous to the stress-temperature phase diagram of SMA materials. Pressurization of an initially 100% austenitic cylinder causes the martensite to initially form at the inner radius. For a relatively thin-walled cylinder the transformation front reaches the outer radius before the transformation has completed at the inner radius, whereas for a thick-walled cylinder the transformation completes at the inner radius while there is still an outer ring of 100% austenite. For a given OD/ID ratio, a critical temperature is derived that stipulates which of these two cases occurs. An analytical result is provided for the pressure that will cause the transformation to complete at the inner radius. During unloading, the reverse transformation can start at either the inner or the outer surface of the cylinder and can propagate outward and then reverse its direction and propagate back to the inner surface. The effect of martensitic transformation on the structural yield strength due to plasticity is also investigated and it is shown that the pressure required to initiate yielding can be substantially decreased or increased depending on the temperature and the state of transformation achieved, even though the yield stress of the material is independent of temperature. Finally, the effectiveness of the Tresca transformation criterion to derive closed-form solutions for this problem is demonstrated by comparing with finite element solutions using the von Mises theory.

  10. Relationship between stiffness, internal cell pressure and shape of outer hair cells isolated from the guinea-pig hearing organ.

    Chan, E; Ulfendahl, M


    The mechanical properties of outer hair cells are of importance for normal hearing, and it has been shown that damage of the cells can lead to a reduction in the hearing sensitivity. In this study, we measured the stiffness of isolated outer hair cells in hyper- and hypotonic conditions, and examined the change in stiffness in relation to the corresponding changes in internal cell pressure and cell shape. The results showed that the axial stiffness of isolated outer hair cells (30-90 microns in length, 8-12 microns in diameter), ranging from 0.13-5.39 mN m-1, was inversely related to cell length. Exposure to hyper- and hypotonic external media with a small percentage change in osmolality caused a similar magnitude of change in cell length and cell diameter, but an average 60% change in cell stiffness. Therefore, a moderate osmotic change in the external medium can lead to a significant alteration in cell stiffness. The findings thus indicate an important contribution of internal cell pressure to cell stiffness.

  11. Benzylammonium Thermometer Ions: Internal Energies of Ions Formed by Low Temperature Plasma and Atmospheric Pressure Chemical Ionization.

    Stephens, Edward R; Dumlao, Morphy; Xiao, Dan; Zhang, Daming; Donald, William A


    The extent of internal energy deposition upon ion formation by low temperature plasma and atmospheric pressure chemical ionization was investigated using novel benzylammonium thermometer ions. C-N heterolytic bond dissociation enthalpies of nine 4-substituted benzylammoniums were calculated using CAM-B3LYP/6-311++G(d,p), which was significantly more accurate than B3LYP/6-311++G(d,p), MP2/6-311++G(d,p), and CBS-QB3 for calculating the enthalpies of 20 heterolytic dissociation reactions that were used to benchmark theory. All 4-substituted benzylammonium thermometer ions fragmented by a single pathway with comparable dissociation entropies, except 4-nitrobenzylammonium. Overall, the extent of energy deposition into ions formed by low temperature plasma was significantly lower than those formed by atmospheric pressure chemical ionization under these conditions. Because benzylamines are volatile, this new suite of thermometer ions should be useful for investigating the extent of internal energy deposition during ion formation for a wide range of ionization methods, including plasma, spray and laser desorption-based techniques. Graphical Abstract ᅟ.

  12. Fuel reactivity and release of pollutants and alkali vapours in pressurized combustion for combined cycle power generation

    Aho, M.; Haemaelaeinen, J.; Paakkinen, K.; Rantanen, J. [VTT Energy, Jyvaeskylae (Finland); Hernberg, R.; Haeyrinen, V.; Joutsenoja, T. [Tampere Univ. of Technology (Finland). Lab. of Plasma Technology


    This project forms a part of the overall Pressurized Power Coal Combustion Project Area (PPFC) which aims at an assessment of the viability and technical merits of pressurized pulverized coal combustion, in an atmosphere of recycled flue gas and oxygen in a coordinated and harmonized programme. The objective of the research at Technical Research Centre of Finland (VTT) and Tampere University of Technology (TUT) is aimed at determining the consequences of solid fuel burning in a mixture of oxygen and recycled flue gases. Combustion conditions of a pressurized entrained flow of pulverized coal and char particles in PEFR are determined with high precision. The effects of experimental parameters on the formation of nitrogen oxides (N{sub 2}O, NO and NO{sub 2}) and gaseous alkali compounds (indicated as NaX(g) and KX(g)) are studied. An effective on-line analysis method for vaporised Na and K compounds was developed. The dependency between particle temperatures and the vaporisation of Na and K was measured with three coals. The results show that alkali removal before gas turbines is always necessary with these coals if combusted in combined cycles. Pressure decreases the formation of NO and has usually no clear effect on the formation of N{sub 2}O. The order of NO/N{sub 2}O ratios correspond to fuel-O/fuel-N ratios. Increase of PO{sub 2} (oxygen concentration) of combustion gas increases the formation of NO{sub 2}. Remarkable concentrations of NO{sub 2} were often measured at high PO{sub 2} at 800-850 deg C. Therefore, NO{sub 2} should be measured from pressurized fluidized bed reactors. Some trends of the formation of NO{sub 2} with coal differ clearly from those with its parent char: N{sub 2}O formation is not strongly temperature dependent with char, and the concentrations of N{sub 2}O formed from char are much lower than those of coal. PO{sub 2} does not effect on the formation of NO from char in the studied range

  13. Comparison of electric and growth responses to excision in cucumber and pea seedlings. II. Long-distance effects are caused by the release of xylem pressure

    Stahlberg, R.; Cosgrove, D. J.


    Excision of a growing stem causes local wound responses, such as membrane depolarization and growth inhibition, as well as effects at larger distances from the cut. In this study, cucumber hypocotyls were excised 100 mm below the hook, so that the growing region was beyond the reach of the wound-induced depolarization (up to 40 mm). Even at such a distance, the cut still caused a considerable and rapid drop in the hypocotyl growth rate. This growth response is not a direct wound response because it does not result from the cut-induced depolarization and because it can be simulated by root pressure manipulation (using a pressure chamber). The results indicate that the growth response resulted from the rapid release of the xylem pressure upon excision. To test this conclusion we measured the xylem pressure by connecting a pressure probe to the cut surface of the stem. Xylem pressure (Px) was found to be +10 to +40 kPa in cucumber hypocotyls and -5 to -10 kPa or lower in pea epicotyls. Excision of the cucumber hypocotyl base led to a rapid drop in Px to negative values, whereas excision in pea led to a rapid rise in Px to ambient (zero) pressure. These fast and opposite Px changes parallel the excision-induced changes in growth rate (GR): a decrease in cucumber and a rise in pea. The sign of the endogenous xylem pressure also determined whether excision induced a propagating depolarization in the form of a slow wave potential (SWP). Under normal circumstances pea seedlings generated an SWP upon excision whereas cucumber seedlings failed to do so. When the Px in cucumber hypocotyls was experimentally inverted to negative values by incubating the cumber roots in solutions of NaCN or n-ethylmaleimide, excision caused a propagating depolarization (SWP). The experiment shows that only hydraulic signals in the form of positive Px steps are converted into propagating electric SWP signals. These propagating depolarizations might be causally linked to systemic 'wound

  14. Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats.

    Drapala, Adrian; Koszelewski, Dominik; Tomasova, Lenka; Ostaszewski, Ryszard; Grman, Marian; Ondrias, Karol; Ufnal, Marcin


    Hydrogen sulfide (H2S) is involved in blood pressure regulation. We evaluated hemodynamic effects of Na2S and morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate (GYY4137), H2S donors. GYY4137 is the most widely studied slow-releasing H2S donor, however, its ability to release H2S under physiological conditions is unclear. Hemodynamics were recorded in anaesthetized Wistar-Kyoto rats at baseline and after intravenous (IV) or intraperitoneal (IP) administration of either a vehicle (20% dimethyl sulfoxide), GYY4137 or Na2S. The stability of GYY4137 in buffers and in plasma was evaluated with nuclear magnetic resonance. The vehicle, as well as GYY4137, given IV did not affect mean arterial blood pressure (MABP), whereas Na2S produced a significant decrease in MABP. Similarly, IP given Na2S, but not GYY4137, lowered MABP. In the buffers at pH of 7.4 and 5.5 and in rat plasma no reaction of GYY4137 was found during 18 hours of observation. In contrast, rapid decomposition of GYY4137 occurred in buffers at pH 2.0. In conclusion, parenteral GYY4137 does not exert a hemodynamic effect in Wistar-Kyoto rats. This seems to be due to the high stability of GYY4137 at physiological pH. Therefore, it is likely that widely reported biological effects of GYY4137 are not H2S-dependent but may depend on GYY4137 itself. However, the H2S-dependent biological effects of GYY4137 may be expected in tissues characterized by low pH.

  15. Computational analysis of heat transfer and pressure drop performance for internally finned tubes with three different longitudinal wavy fins

    Wang, Qiu-Wang; Lin, Mei; Zeng, Min; Tian, Lin [Xi' an Jiaotong University, State Key Laboratory of Multiphase Flow in Power Engineering, Xi' an, Shaanxi (China)


    Turbulent pressure drop and heat transfer characteristics in tubes with three different kinds of internally longitudinal fin patterns (interrupted wavy, sinusoidal wavy and plain) are numerically investigated for Re=904-4,520. The channel velocity, temperature, and turbulence fields are obtained to discern the mechanisms of heat transfer enhancement. Numerical results indicate that the steady and spatially periodic growth and disruption of cross-sectional vortices occur near the tube/fin walls along the streamwise locations. The thermal boundary layers near the tube/fin surfaces are thereby periodically interrupted, with heat transfer near the recirculation zones being enhanced. The overall heat transfer coefficients in wavy channels are higher than those in a plain fin channel, while with larger pressure drop penalties. At the same waviness, the interrupted wavy fin tube could enhance heat transfer by 72-90%, with more than 2-4 times of pressure drop penalty. Among the fins studied, the sinusoidal wavy fin has the best comprehensive performance. (orig.)

  16. International Space Station (ISS) Bacterial Filter Elements (BFEs): Filter Efficiency and Pressure Drop Testing of Returned Units

    Green, Robert D.; Agui, Juan H.; Vijayakumar, R.; Berger, Gordon M.; Perry, Jay L.


    The air quality control equipment aboard the International Space Station (ISS) and future deep space exploration vehicles provide the vital function of maintaining a clean cabin environment for the crew and the hardware. This becomes a serious challenge in pressurized space compartments since no outside air ventilation is possible, and a larger particulate load is imposed on the filtration system due to lack of sedimentation. The ISS Environmental Control and Life Support (ECLS) system architecture in the U.S. Segment uses a distributed particulate filtration approach consisting of traditional High-Efficiency Particulate Air (HEPA) filters deployed at multiple locations in each U.S. Seg-ment module; these filters are referred to as Bacterial Filter Elements, or BFEs. In our previous work, we presented results of efficiency and pressure drop measurements for a sample set of two returned BFEs with a service life of 2.5 years. In this follow-on work, we present similar efficiency, pressure drop, and leak tests results for a larger sample set of six returned BFEs. The results of this work can aid the ISS Program in managing BFE logistics inventory through the stations planned lifetime as well as provide insight for managing filter element logistics for future exploration missions. These results also can provide meaningful guidance for particulate filter designs under consideration for future deep space exploration missions.

  17. An investigation into the heat transfer characteristics of spiral wall with internal rib in a supercritical sliding-pressure operation once-through boiler

    TANG Renhu; YIN Fei; WANG Haijun; CHEN Tingkuan


    Within the pressure range of 9-28 MPa,mass 200-500 kW/m2,experiments were performed to investigate the heat transfer to water in the inclined upward internally ribbed tube with an inclined angle of 19.5 degrees,a maximum outer diameter of 38.1 mm,and a thickness of 7.5 mm.Based on the experiments,it was found that heat transfer enhancement of the internally ribbed tube could postpone departure from nucleate boiling at the sub-critical pressure.However,the heat transfer enhancement decreased near the critical pressure.At supercritical pressure,the temperature difference between the wall and the fluid increased near the pseudo-critical temperature,but the increase of wall temperature was less than that of departure from nucleate boiling at sub-critical pressure.When pressure is closer to the critical pressure,the temperature difference between the wall and the fluid increased greatly near the pseudo-critical temperature.Heat transfer to supercritical water in the inclined upward internally ribbed tube was enhanced or deteriorated near the pseudo-critical temperature with the variety of ratio between the mass velocity and the heat flux.Because the rotational flow of the internal groove reduced the effect of natural convection,the internal wall temperature of internally ribbed tube uniformly distributed along the circumference.The maximum internal wall temperature difference of the tube along the circumference was only 10 degrees when the fluid enthalpy exceeded 2 000 J/g.Considering the effect of acute variety of the fluid property on heat transfer,the correlation of heat transfer coefficient on the top of the internally ribbed tube was orovided.

  18. Modernization of Cross Section Library for VVER-1000 Type Reactors Internals and Pressure Vessel Dosimetry

    Voloschenko Andrey


    Full Text Available The broad-group library BGL1000_B7 for neutron and gamma transport calculations in VVER-1000 internals, RPV and shielding was carried out on a base of fine-group library v7-200n47g from SCALE-6 system. The comparison of the library BGL1000_B7 with the library v7-200n47g and the library BGL1000 (the latter is using for VVER-1000 calculations is demonstrated on several calculation and experimental tests.

  19. Modernization of Cross Section Library for VVER-1000 Type Reactors Internals and Pressure Vessel Dosimetry

    Voloschenko, Andrey; Zaritskiy, Sergey; Egorov, Aleksander; Boyarinov, Viktor


    The broad-group library BGL1000_B7 for neutron and gamma transport calculations in VVER-1000 internals, RPV and shielding was carried out on a base of fine-group library v7-200n47g from SCALE-6 system. The comparison of the library BGL1000_B7 with the library v7-200n47g and the library BGL1000 (the latter is using for VVER-1000 calculations) is demonstrated on several calculation and experimental tests.

  20. Evaluation of blood pressure and heart rate in patients with hypertension who received tapentadol extended release for chronic pain: a post hoc, pooled data analysis.

    Biondi, David M; Xiang, Jim; Etropolski, Mila; Moskovitz, Bruce


    Hypertension is one of the most common co-existing conditions in patients with chronic pain, and the potential effects of an analgesic on heart rate and blood pressure are of particular concern for patients with hypertension. The purpose of this analysis was to evaluate changes in blood pressure and heart rate with tapentadol extended release (ER) treatment in patients with hypertension. We performed a post hoc analysis of data pooled from three randomized, placebo- and active-controlled, phase III studies of tapentadol ER for managing chronic osteoarthritis knee (NCT00421928, NCT00486811) or low back (NCT00449176) pain (15-week, double-blind treatment period). Data were independently analyzed for patients with a listed medical history of hypertension at baseline and patients with at least one listed concomitant antihypertensive medication at baseline. Heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured at each visit. In patients with a listed medical history of hypertension (n = 1,464), least-squares mean (LSM [standard error (SE)]) changes from baseline to endpoint with placebo, tapentadol ER, and oxycodone HCl controlled release (CR), respectively, were -0.7 (0.44), 0.2 (0.43), and -0.9 (0.45) beats per minute (bpm) for heart rate; -2.4 (0.64), -2.7 (0.64), and -3.7 (0.67) mmHg for SBP; and -1.0 (0.39), -1.3 (0.39), and -2.3 (0.41) mmHg for DBP; in patients with at least one listed concomitant antihypertensive medication (n = 1,376), the LSM (SE) changes from baseline to endpoint were -0.6 (0.45), 0.1 (0.44), and -0.7 (0.47) bpm for heart rate; -1.8 (0.66), -3.3 (0.65), and -3.7 (0.69) mmHg for SBP; and -0.7 (0.40), -1.4 (0.40), and -2.3 (0.42) mmHg for DBP. No clinically meaningful mean changes in heart rate or blood pressure were observed for the evaluated cohorts of patients with hypertension who were treated with tapentadol ER (100-250 mg twice daily).

  1. Subaquatic, pressure vessels and LPG storage spheres internal inspection; Inspecao interna de esfera utilizando mergulho como acesso

    Filgueira Filho, Rafael; Monteiro, Ayres [PETROBRAS, Rio de Janeiro, RJ (Brazil)


    Minimizing shut-down costs is a widespread target in the oil and gas industry. The use of new inspection techniques is one of the ways for that. This work presents a new procedure for internal inspections in pressure vessels by the non destructive testing - NDT, ACFM, using industrial diving techniques. As a pioneer experience, this method was applied in the inspection of the internal parts of the LPG sphere tank 5101 at PETROBRAS Transporte S.A. - TRANSPETRO, in Jequie's Terminal, in the state of Bahia, in december, 2003. This new method allows the reduction of indirect costs related to operational unavailability of the equipment, by the reduction of the shut-down time in approximately 50%, when compared to the demanded shut down time, when using scaffolds for accessing the internal parts. Despite of direct costs are still higher with the new methodology, this paper demonstrates the economical feasibility of this new method, based on the savings obtained with the fastest return of the equipment to operation. (author)

  2. Modelling of heat and mass transfer in a granular medium during high-temperature air drying. Effect of the internal gas pressure

    Othmani, Hammouda; Hassini, Lamine; Lamloumi, Raja; El Cafsi, Mohamed Afif


    A comprehensive internal heat and water transfer model including the gas pressure effect has been proposed in order to improve the industrial high-temperature air drying of inserts made of agglomerated sand. In this model, the internal gas phase pressure effect was made perfectly explicit, by considering the liquid and vapour transfer by filtration and the liquid expulsion at the surface. Wet sand enclosed in a tight cylindrical glass bottle dried convectively at a high temperature was chosen as an application case. The model was validated on the basis of the experimental average water content and core temperature curves for drying trials at different operating conditions. The simulations of the spatio-temporal distribution of internal gas pressure were performed and interpreted in terms of product potential damage. Based on a compromise between the drying time and the pressure increase, a simple drying cycle was implemented in order to optimize the drying process.

  3. The effect of government internal auditors moral reasoning and situational pressure on the tendency to commit fraud when auditing: An experimental study

    Novita Puspasari


    Full Text Available This study aims to examine the effect of government internal auditors moral levels and situational pressures on the tendency to commit fraud when conducting audit. Based on the hypothesis, despite the situational pressures, the government internal auditors who have a high moral level will not commit fraud at the time of auditing. Meanwhile, the government internal auditors who have a low moral level will com-mit fraud at the time of auditing when there is situational pressure. To test the hypothesis, a 22 factorial experiment is conducted involving 68 students of STAR-BPKP of Jenderal Soedirman University. The results indicate that the government internal auditors who have a high moral level will not commit fraud in the time of auditing despite some situational pressures. Meanwhile, the government internal auditors who have a low moral level will commit fraud at the time of auditing either there is a situational pressure or not. The implications of this study are to streng-then the supervisory system for the internal auditors at the time of auditing, to provide protection for whistle- blowers who report the presence of fraud committed by auditors, and to be consistent in giving reward to professional auditors and pu-nishment to auditors who are convicted of fraud at the time of auditing.

  4. Tuberculosis screening using a T-cell interferon-γ release assay in Japanese medical students and non-Japanese international students.

    Ogiwara, Takayuki; Kimura, Takao; Tokue, Yutaka; Watanabe, Rumi; Nara, Makoto; Obuchi, Toshiko; Yaegashi, Akiko; Yomoda, Sachie; Ohshima, Kihachi; Murakami, Masami


    Screening of medical students and international students for tuberculosis (TB) at the time of admission is a key strategy to control and prevent the spread of infection on university campus and teaching hospitals because of the high risk of exposure to TB patients. The Mycobacterium tuberculosis antigen-specific T-cell interferon-γ release assays (IGRAs) are specific latent tuberculosis detection methods used in such groups. Currently, in Japan, there are no guidelines and no baseline data on IGRAs to evaluate the risk of TB in these high-risk groups. In order to evaluate TB risk at the time of admission in university campus and medical schools in Japan, a retrospective study was conducted. A total of 969 students (585 Japanese students and 384 international students) were screened for TB using the IGRAs at the time of admission. Eight Japanese students (0.9%) were positive for IGRAs, but none were diagnosed with active TB at the follow-up. In contrast, 30 international students (7.8%) were positive for IGRAs, including two students diagnosed with active TB during follow up. Positive ratio of IGRAs in international students was significantly higher than that of medical students at the time of admission. Here we propose a standard approach for TB screening with IGRAs at the time of admission for medical students and international students in Japan.

  5. Domestic Polymerization Inhibitor BL-628B Used in High-Pressure Depropanizer of Ethylene Unit Commands an International Leading Position


    @@ The high-pressure depropanizer of the 180 kt/a ethylene unit at the SINOPEC's Zhongyuan Petrochemical Limited Liability Company has been smoothly operating for three years since the adoption of the polymerization inhibitor BL-62B manufactured by the Beijing Sparrow Science and Technology Company to achieve first in China the target on a threeyear long-cycle,overloaded and stable operation.The large ethylene unit at PetroChina's Lanzhou Petrochemical Company will shortly apply this polymerization inhibitor to substitute for the imported additive,symbolizing the indigenous mature technology for inhibiting polymerization in the HP depropanizer by means of the multifunctional additive under high load with the product quality reaching the internationally advanced level.

  6. The effect of the egg's shape on the stress distribution in the eggshell at internal pressure loading

    Šárka Nedomová


    Full Text Available The influence of the eggshell shape on the stress distribution under internal pressure is studied. A mathematical description of the hen's eggshell is proposed. The analytical expressions for the membrane solution are presented. Obtained results are used for the evaluation of a set of domestic hen's eggs. 28 eggs were analysed in this study. The weight of eggs ranged from 49.55 g to 61.08 g, the egg shape ranged from 72.82 % to 84.94 %, the average eggshell thickness ranged from 0.343 to 0.433 mm. The eggshell strength is given namely by the maximum values both of meridian and circumferential forces. The dependence of the meridian force maximum on the egg shape index has some tendency to increase with egg shape index. The outlined linear dependence is very weak, the coefficient of correlation is about 0.45.

  7. Severe pediatric acute respiratory distress syndrome due to scrub typhus: Successful ventilation with airway pressure release ventilation mode after becoming refractory to protective ventilation

    Sudha Chandelia


    Full Text Available Scrub typhus can affect lungs from mild illness like pneumonitis to a severe illness like acute respiratory distress syndrome (ARDS. Such patients may be very challenging to treat when their hypoxemia becomes severe and refractory to treatment. Main treatment is supportive in terms of mechanical ventilation. In adult ARDS, low tidal volume (TV ventilation has been recommended, but there is no consensus on most effective ventilation mode in children. We present a case of a 12-year-old girl who developed severe ARDS (PO 2 /FiO 2 ratio - 58, refractory to low TV ventilation. There was a rapid improvement in oxygenation on the application of airway pressure release ventilation (APRV mode within ΍ h. She was successfully ventilated and weaned off the ventilator over 5 days. This case highlights the utility of APRV mode of ventilation as a rescue therapy for severe refractory ARDS in children.

  8. Internalization of appearance ideals mediates the relationship between appearance-related pressures from peers and emotional eating among adolescent boys and girls.

    Thompson, Katherine A; Kelly, Nichole R; Schvey, Natasha A; Brady, Sheila M; Courville, Amber B; Tanofsky-Kraff, Marian; Yanovski, Susan Z; Yanovski, Jack A; Shomaker, Lauren B


    Appearance-related pressures have been associated with binge eating in previous studies. Yet, it is unclear if these pressures are associated with emotional eating or if specific sources of pressure are differentially associated with emotional eating. We studied the associations between multiple sources of appearance-related pressures, including pressure to be thin and pressure to increase muscularity, and emotional eating in 300 adolescents (Mage=15.3, SD=1.4, 60% female). Controlling for age, race, puberty, body mass index (BMI) z-score, and sex, both pressure to be thin and pressure to be more muscular from same-sex peers were positively associated with emotional eating in response to feeling angry/frustrated and unsettled (psPressure from same-sex peers to be more muscular also was associated with eating when depressed (ppressure from opposite-sex peers related to eating in response to anger/frustration (ppressures from mothers and fathers with emotional eating were non-significant. Results considering sex as a moderator of the associations between appearance-related pressures and emotional eating were non-significant. Findings illustrate that both pressure to be thin and muscular from peers are related to more frequent emotional eating among both boys and girls, and these associations are explained through internalization of appearance-related ideals. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Ultimate analysis of a 1/4-scale prestressed concrete containment vessel model subject to internal pressure

    Lee, Young Jung; Choun, Young Sun; Lee, Sang Jin; Choi, In Kil; Kim, Hyun Ah [Korea Atomic Energy Research Institute, Taejeon (Korea)


    The research on the investigation of ultimate capacity and integrity of the containment structures has been internationally performed since the late 1980's. However, it is almost impossible to predict the behavior and ultimate capacity of concrete structures with enough accuracy, because of the uncertainties in material properties of concrete. Especially it is a difficult task to predict the response of containment structures with numerical methods since the complex behaviors of concrete appear with crack formation. The objectives of this research are to establish and develop nonlinear analysis procedures for ultimate capacity of prestressed concrete containment structure subject to internal pressure. In this research 20 and 3D numerical analysis procedures are accomplished and fully evaluated by the test result of 1/4-scale model of a prestressed concrete containment that was tested by SNL. The computer program ABAQUS was used to analyze the 1/4-scale model. There is the limitation in the estimation of nonlinear response of containment with 2D analysis since it simple and doesn't consider penetrations although it has been widely used. Therefore in this research 3D FE analysis considering discontinuity was performed to estimate the response of containment together with 2D FE analysis. And the results of analysis were compared with the results of the pretest Round Robin Analysis of the PCCV model to examine the validity of analytical methods. 14 refs., 40 figs., 22 tabs. (Author)

  10. [A case of respiratory insufficiency after resection of the aortic aneurysm and replacement with a synthetic conduit which recovered by airway pressure release ventilation].

    Shimoyama, Yuichiro; Majima, Nozomi; Kadono, Noriko; Ito, Masayuki; Agui, Tomoyuki; Umegaki, Osamu; Minami, Toshiaki


    We experienced a patient with respiratory insufficiency after resection of the aortic aneurysm and replacement with a synthetic conduit which recovered by airway pressure release ventilation (APRV) dramatically. A 44-year-old man diagnosed as aortic aneurysm of the descending thoracic aorta was admitted to our hospital and an operation was scheduled. The operation lasted for 19 hours and the time of general anesthesia was 23 hours. The immediate post-operative chest x-ray showed atelectasis of the right upper lobe, elevated right diaphragm and poor aeration of the lungs. A volume-limited mechanical ventilation was used for this patient postoperatively in ICU. But accumulation of carbon dioxide and poor oxygenation were observed. We started APRV by Bennet 840 (Tyco Healthcare, Tokyo). Specifically, we used Bilevel mode (PEEP 20/3 cmH20/3, inspiratory time 3.2 seconds, respiratory rate 15 times per minute, pressure support 20 cm H2O, FI(O2) 1.0). Promptly accumulation of carbon dioxide was improved and atelectasis of the right upper lobe vanished. Additionally, oxygenation was improved. He was weaned from a ventilator on postoperative day 5. We have demonstrated that APRV is an important tool that should be used to improve severe respiratory insufficiency.

  11. Cenosphere formation from heavy fuel oil: a numerical analysis accounting for the balance between porous shells and internal pressure

    Vanteru, Mahendra Reddy


    Heavy fuel oil (HFO) as a fuel in industrial and power generation plants ensures the availability of energy at economy. Coke and cenosphere emissions from HFO combustion need to be controlled by particulate control equipment such as electrostatic precipitators, and collection effectiveness is impacted by the properties of these particulates. The cenosphere formation is a function of HFO composition, which varies depending on the source of the HFO. Numerical modelling of the cenosphere formation mechanism presented in this paper is an economical method of characterising cenosphere formation potential for HFO in comparison to experimental analysis of individual HFO samples, leading to better control and collection. In the present work, a novel numerical model is developed for understanding the global cenosphere formation mechanism. The critical diameter of the cenosphere is modelled based on the balance between two pressures developed in an HFO droplet. First is the pressure (Prpf) developed at the interface of the liquid surface and the inner surface of the accumulated coke due to the flow restriction of volatile components from the interior of the droplet. Second is the pressure due to the outer shell strength (PrC) gained from van der Walls energy of the coke layers and surface energy. In this present study it is considered that when PrC ≥ Prpf the outer shell starts to harden. The internal motion in the shell layer ceases and the outer diameter (DSOut) of the shell is then fixed. The entire process of cenosphere formation in this study is analysed in three phases: regression, shell formation and hardening, and post shell hardening. Variations in pressures during shell formation are analysed. Shell (cenosphere) dimensions are evaluated at the completion of droplet evaporation. The rate of fuel evaporation, rate of coke formation and coke accumulation are analysed. The model predicts shell outer diameters of 650, 860 and 1040 µm, and inner diameters are 360, 410

  12. International challenge to predict the impact of radioxenon releases from medical isotope production on a comprehensive nuclear test ban treaty sampling station

    Eslinger, Paul W.; Bowyer, Ted W.; Achim, Pascal; Chai, Tianfeng; Deconninck, Benoit; Freeman, Katie; Generoso, Sylvia; Hayes, Philip; Heidmann, Verena; Hoffman, Ian; Kijima, Yuichi; Krysta, Monika; Malo, Alain; Maurer, Christian; Ngan, Fantine; Robins, Peter; Ross, J. Ole; Saunier, Olivier; Schlosser, Clemens; Schöppner, Michael; Schrom, Brian T.; Seibert, Petra; Stein, Ariel F.; Ungar, Kurt; Yi, Jing


    Abstract The International Monitoring System (IMS) is part of the verification regime for the Comprehensive Nuclear-Test-Ban-Treaty Organization (CTBTO). At entry-into-force, half of the 80 radionuclide stations will be able to measure concentrations of several radioactive xenon isotopes produced in nuclear explosions, and then the full network may be populated with xenon monitoring afterward (Bowyer et al., 2013). Fission-based production of 99Mo for medical purposes also releases radioxenon isotopes to the atmosphere (Saey, 2009). One of the ways to mitigate the effect of emissions from medical isotope production is the use of stack monitoring data, if it were available, so that the effect of radioactive xenon emissions could be subtracted from the effect from a presumed nuclear explosion, when detected at an IMS station location. To date, no studies have addressed the impacts the time resolution or data accuracy of stack monitoring data have on predicted concentrations at an IMS station location. Recently, participants from seven nations used atmospheric transport modeling to predict the time-history of 133Xe concentration measurements at an IMS station in Germany using stack monitoring data from a medical isotope production facility in Belgium. Participants received only stack monitoring data and used the atmospheric transport model and meteorological data of their choice. Some of the models predicted the highest measured concentrations quite well (a high composite statistical model comparison rank or a small mean square error with the measured values). The results suggest release data on a 15 min time spacing is best. The model comparison rank and ensemble analysis suggests that combining multiple models may provide more accurate predicted concentrations than any single model. Further research is needed to identify optimal methods for selecting ensemble members and those methods may depend on the specific transport problem. None of the submissions based only

  13. A New Method for Simultaneous Determination of the TDC Offset and the Pressure Offset in Fired Cylinders of an Internal Combustion Engine

    Urban Žvar Baškovič


    Full Text Available An innovative computationally efficient method for the simultaneous determination of top dead centre (TDC offset and pressure offset is presented. It is based on characteristic deviations of the rate of heat release (ROHR that are specific for both offsets in compression phase and expansion phase after the end of combustion. These characteristic deviations of the ROHR are derived from first principles and they were also confirmed through manual shifts of the pressure trace. The ROHR is calculated based on the first law of thermodynamics using an in-cylinder pressure trace, engine geometrical parameters and operating point specific parameters. The method can be applied in off-line analyses using an averaged pressure trace or in on-line analyses using a single pressure trace. In both application areas the method simultaneously determines the TDC position and the pressure offset within a single processing of the pressure trace, whereas a second refinement step can be performed for obtaining more accurate results as correction factors are determined more accurately using nearly converged input data. Innovative analytic basis of the method allows for significant reduction of the computational times compared to the existing methods for the simultaneous determination of TDC offset and pressure offset in fired conditions. The method was validated on a heavy-duty and a light-duty diesel engine.

  14. Pituitary binding and internalization of radioiodinated gonadotropin-releasing hormone agonist and antagonist ligands in vitro and in vivo

    Wynn, P.C.; Suarez-Quian, C.A.; Childs, G.V.; Catt, K.J.


    In rat pituitary gonadotrophs, the rates of binding and endocytosis of two GnRH superagonist analogs, (D-Ala6,Pro9-NEt)GnRH and (D-Lys6,Pro9-NEt)GnRH, were compared with those of the potent antagonist analog (N-acetyl-D-pCl-Phe1,2,D-Trp3,D-Lys6,D-Ala10)GnRH by quantitative electron microscopic autoradiography. In dispersed pituitary cells, the two agonist analogs showed similar binding kinetics and comparable degrees of sequestration, as measured by their resistance to dissociation by low pH buffer. However, quantification of silver grain localization suggested that cellular internalization of the (D-Ala6)GnRH agonist increased more rapidly than that of the (D-Lys6)GnRH analog. These discrepancies, and the finding that a larger amount of the specifically bound /sup 125/I-(D-Ala6)GnRH agonist was removed during glutaraldehyde fixation, indicated that the proportional internalization of this analog was over estimated by quantitative autoradiography owing to loss of cell surface-bound radioligand. We, therefore, employed radioiodinated D-Lys6-substituted analogs to analyze the receptor binding and cellular uptake of GnRH agonist and antagonist derivatives in vivo. After iv injection, a high proportion of the /sup 125/I-(D-Lys6)GnRH agonist was translocated into pituitary gonadotrophs within 60 min, whereas the D-Lys6 antagonist was predominantly associated with the plasma membrane during that time. Four hours after injection of the antagonist, an appreciable proportion of silver grains was associated with intracellular organelles, and this trend increased progressively at later time points. The relatively prolonged cellular processing of the GnRH antagonist is consistent with in vivo binding kinetics, and its slower internalization may reflect the basal rate of GnRH receptor turnover in the cell membrane.

  15. Contact behavior analysis of elastomeric x-ring under uniform squeeze rate and internal pressure before and after forcing-out using the photoelastic experimental hybrid method

    Bernard, Alunda Ouma [Dedan Kimathi University of Technology, Nyeri (Kenya); Hawong, Jai Sug; Dong, Bai [Yeungnam University, Gyeongsan (Korea, Republic of); Shin, Dong Chul [Koje College, Geoje (Korea, Republic of)


    Many different types of elastomeric rings have been developed to suit various needs in industry. The X-ring was introduced as a result of the limitations of O-rings that twist, especially during dynamic application. A better understanding of the behavior and the stress distribution of the X-ring under a uniform squeeze rate and internal pressure is needed. We analyzed the contact stresses and internal stresses developed in an X-ring before and after forcing-out by using the photoelastic experimental hybrid method, ascertained the packing ability of an X-ring, and studied the failure criterion of an X-ring under uniform squeeze rate and internal pressure. Forcing-out in the X-ring occurred when the internal pressure was 3.92 MPa. After forcing-out, at an internal pressure of 5.88 MPa, the two lobes on the upper contact surface merged one contact side of the upper side immensely. Even after extrusion of the X-ring, the X-ring can be used to effectively contain the fluid. This is because the effects of extrusion on the X-ring affected the stress distribution of only two lobes close to the assembly gap and the two lobes are merge into one lobe. In addition, our experimental results show that the maximum shear failure criterion is suitable for the prediction of failure in X-ring seals.

  16. Irradiation testing of internally pressurized and/or graphite coated Zircaloy-4 clad fuel rods in the NRX Reactor (AWBA Development Program). [LWBR

    Hoffman, R.C.; Sherman, J.


    Irradiation tests on 0.612 inch O.D. by 117-inch long Zircaloy-4 clad fuel rods were performed to assess the effects on fuel rod performance of (1) internal helium pre-pressurization to 500 psi as fabricated, (2) the presence of a graphite barrier coating on the inside cladding surface, and (3) combined pre-pressurization and graphite coating. Periodic dimensional examinations were performed on the test rods, and the results were compared with data obtained from two previously irradiated test rods--both unpressurized and uncoated and one intentionally defected. These comparisons indicate that both pre-pressurization and graphite coating can substantially improve fuel element performance capability.

  17. Tailoring the internal structure of liquid crystalline nanoparticles responsive to fungal lipases: A potential platform for sustained drug release.

    Poletto, F S; Lima, F S; Lundberg, D; Nylander, T; Loh, W


    Lipases are key components in the mechanisms underlying the persistence and virulence of infections by fungi, and thus also promising triggers for bioresponsive lipid-based liquid crystalline nanoparticles. We here propose a platform in which only a minor component of the formulation is susceptible to cleavage by lipase and where hydrolysis triggers a controlled phase transition within the nanoparticles that can potentially allow for an extended drug release. The responsive formulations were composed of phytantriol, which was included as a non-cleavable major component and polysorbate 80, which serves both as nanoparticle stabilizer and potential lipase target. To monitor the structural changes resulting from lipase activity with sufficient time resolution, we used synchrotron small angle x-ray scattering. Comparing the effect of the two different lipases used in this work, lipase B from Candida Antarctica, (CALB) and lipase from Rhizomucor miehei (RMML), only CALB induced phase transition from bicontinuous reverse cubic to reverse hexagonal phase within the particles. This phase transition can be attributed to an increasing amount of oleic acid formed on cleavage of the polysorbate 80. However, when also a small amount of a cationic surfactant was included in the formulation, RMML could trigger the corresponding phase transition as well. The difference in activity between the two lipases can tentatively be explained by a difference in their interaction with the nanoparticle surface. Thus, a bioresponsive system for treating fungal infections, with a tunable selectivity for different types of lipases, could be obtained by tuning the composition of the nanoparticle formulation.

  18. High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle

    Timo KIRSCHSTEIN; Mirko REHBERG; Rika BAJORAT; Tursonjan TOKAY; Katrin PORATH; Rudiger KOHLING


    Aim: Depolarization-induced contraction of smooth muscle is thought to be mediated by Ca2+influx through voltage-gated L-type Ca2+channels. We describe a novel contraction mechanism that is independent of Ca2+ entry.Methods: Pharmacological experiments were carried out on isolated rat gut longitudinal smooth muscle preparations, measuring iso-metric contraction strength upon high K+-induced depolarization.Results: Treatment with verapamil, which presumably leads to a conformational change in the channel, completely abolished K+-induced contraction, while residual contraction still occurred when Ca2+ entry was blocked with Cd2+. These results were further con-firmed by measuring intracellular Ca2+ transients using Fura-2. Co-application of Cd2+ and the ryanodine receptor blocker DHBP further reduced contraction, albeit incompletely. Additional blockage of either phospholipase C (U 73122) or inositol 1,4,5-trisphophate (IP3)receptors (2-APB) abolished most contractions, while sole application of these blockers and Cd2+ (without parallel ryanodine receptor manipulation) also resulted in incomplete contraction block.Conclusion: We conclude that there are parallel mechanisms of depolarization-induced smooth muscle contraction via (a) Ca2+ entry and (b) Ca2+ entry-independent, depolarization-induced Ca2+-release through ryanodine receptors and IP3, with the latter being depen-dent on phospholipase C activation.

  19. Estimation of C*-Integral for Radial Cracks in Annular Discs under Constant Angular Velocity and Internal Pressure

    A. R. Gowhari-Anaraki


    Full Text Available The finite element method has been used to predict the creep rupture parameter, C*-Integral for single and double-edge cracks in eight annular rotating discs under constant angular velocity with and without internal pressure. In this study, a new dimensionless creeping crack configuration factor, Q* has been introduced. Power law creeping finite element analyses have been performed and the results are presented in the form of Q* for a wide range of components and crack geometry parameters. These parameters are chosen to be representative of typical practical situations and have been determined from evidence presented in the open literature. The extensive range of Q* obtained from the analyses are then used to obtain equivalent prediction equations using a statistical multiple non-linear regression model. The predictive equations for Q*, can also be used easily to calculate the C*-Integral values for extensive range of geometric parameters. The C*-Integral values obtained from predictive equations were also compared with those obtained from reference stress method (RSM. Finally, creep zone growth behavior was studied in the component during transient time.

  20. Numerical study with experimental comparison of pressure waves in the air intake system of an internal combustion engine

    Falcao, Carlos E.G.; Vielmo, Horacio A. [Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Mechanical Engineering Dept.], E-mails:; Hanriot, Sergio M. [Pontifical Catholic University of Minas Gerais (PUC-Minas), Belo Horizonte, MG (Brazil). Mechanical Engineering Dept.], E-mail:


    The work investigates the pressure waves behavior in the intake system of an internal combustion engine. For the purpose of examining this problem, it was chosen an experimental study in order to validate the results of the present simulation. At the literature there are several experimental studies, and some numerical simulations, but the most of the numerical studies treat the problem only in one dimension in practical problems, or two dimensions in specific problems. Using a CFD code it is possible to analyze more complex systems, including tridimensional effects. The pulsating phenomenon is originated from the periodic movement of the intake valve, and produces waves that propagate within the system. The intake system studied was composed by a straight pipe connected to a 1000 cc engine with a single operating cylinder. The experiments were carried out in a flow bench. In the present work, the governing equations was discretized by Finite Volumes Method with an explicit formulation, and the time integration was made using the multi-stage Runge-Kutta time stepping scheme. The solution is independent of mesh or time step. The numerical analysis presents a good agreement with the experimental results. (author)

  1. International challenge to predict the impact of radioxenon releases from medical isotope production on a comprehensive nuclear test ban treaty sampling station.

    Eslinger, Paul W; Bowyer, Ted W; Achim, Pascal; Chai, Tianfeng; Deconninck, Benoit; Freeman, Katie; Generoso, Sylvia; Hayes, Philip; Heidmann, Verena; Hoffman, Ian; Kijima, Yuichi; Krysta, Monika; Malo, Alain; Maurer, Christian; Ngan, Fantine; Robins, Peter; Ross, J Ole; Saunier, Olivier; Schlosser, Clemens; Schöppner, Michael; Schrom, Brian T; Seibert, Petra; Stein, Ariel F; Ungar, Kurt; Yi, Jing


    The International Monitoring System (IMS) is part of the verification regime for the Comprehensive Nuclear-Test-Ban-Treaty Organization (CTBTO). At entry-into-force, half of the 80 radionuclide stations will be able to measure concentrations of several radioactive xenon isotopes produced in nuclear explosions, and then the full network may be populated with xenon monitoring afterward. An understanding of natural and man-made radionuclide backgrounds can be used in accordance with the provisions of the treaty (such as event screening criteria in Annex 2 to the Protocol of the Treaty) for the effective implementation of the verification regime. Fission-based production of (99)Mo for medical purposes also generates nuisance radioxenon isotopes that are usually vented to the atmosphere. One of the ways to account for the effect emissions from medical isotope production has on radionuclide samples from the IMS is to use stack monitoring data, if they are available, and atmospheric transport modeling. Recently, individuals from seven nations participated in a challenge exercise that used atmospheric transport modeling to predict the time-history of (133)Xe concentration measurements at the IMS radionuclide station in Germany using stack monitoring data from a medical isotope production facility in Belgium. Participants received only stack monitoring data and used the atmospheric transport model and meteorological data of their choice. Some of the models predicted the highest measured concentrations quite well. A model comparison rank and ensemble analysis suggests that combining multiple models may provide more accurate predicted concentrations than any single model. None of the submissions based only on the stack monitoring data predicted the small measured concentrations very well. Modeling of sources by other nuclear facilities with smaller releases than medical isotope production facilities may be important in understanding how to discriminate those releases from

  2. Validation of the Samsung SBM-100A and Microlife BP 3BU1-5 wrist blood pressure measuring devices in adults according to the International Protocol.

    Altunkan, Sekip; Ilman, Nevzat; Altunkan, Erkan


    A variety of automatic blood measurement devices with diverse features have been introduced to the medical markets recently. Among these devices, models that measure at the wrist have become increasingly popular in self measurements. The objective of this study was to evaluate the accuracy of the Samsung SBM-100A and Microlife BP 3BU1-5 wrist blood pressure devices against the mercury sphygmomanometer in adults according to the International Protocol criteria. Fifty-four patients over 30 years of age were studied and classified based on the International Protocol range. Blood pressure measurements at the wrist with the Samsung SBM-100A and Microlife BP 3BU1-5 were compared with the results obtained by two trained observers using a mercury sphygmomanometer. Nine sequential blood pressure measurements were taken. A total of 33 participants with randomly distributed arm circumferences were selected for both of the validation studies. During each validation study, 99 measurements were obtained for comparison from 33 participants. The first phase was performed on 15 participants and if the device passed this phase, 18 more participants were selected. Mean discrepancies and standard deviations of the device-sphygmomanometer were 0.9+/-9.2 and -2.7+/-9.3 mmHg for systolic blood pressure and -1.4+/-8.0 mmHg and 1.4+/-5.7 for diastolic blood pressure in the Samsung and Microlife study groups, respectively. The Samsung SBM-100A passed Phase 1 in 15 participants. Despite the fact that Microlife BP 3BU1-5 passed Phase 1 for diastolic pressure, it failed according to the systolic pressure criteria. Eighteen patients were added and Phase 2 was continued, in which Samsung SBM-100A failed to meet the criteria of Phases 2.1 and 2.2 for adults in systolic and diastolic blood pressure. It was found that the Microlife BP 3BU1-5 does not meet the criteria of either of Phases 2.1 and 2.2 for systolic blood pressure and Phase 2.2 for diastolic blood pressure. In this study, Samsung SBM

  3. The Comparison of the Effects of Trigger Points Pressure Release and Kinesio Taping on Pain and Hip Abductor Muscles Strength in Patients with Patellofemoral Pain Syndrome

    Vahid Mazloum


    Full Text Available Background & objectives: Hip muscles insufficiency plays a significant role in deterioration of patellofemoral pain syndrome (PFPS, which can be manifested as myofascial trigger point (MTrPs in hip muscles. Then, our purpose was to determine the prevalence of MTrPs in the gluteus medius (GMe and quadratus lumborum (QL muscles and to investigate the effect of a therapeutic intervention on pain intensity and hip abductor muscles isometric strength in patients with PFPS. Methods: Forty volunteer subjects (20 patients and 20 healthy participated in the study. Latent MTrPs in GMe and QL were evaluated and a handheld dynamometer was used to measure peak isometric strength test (PIST for hip abductors. Patients with PFPS having MTrPs in GMe were randomly divided into either a treatment group (Mean age±SD: 23.2±4.3 years or control (Mean age±SD: 24.4±4.6 years. The therapeutic intervention included trigger point pressure release (TrPPR and Kinesio Taping® (KT. Pain intensity and PIST for hip abductors were assessed at baseline and after intervention in both groups. Results: There is more significant patients with PFPS having latent MTrPs in GMe and QL than the healthy counterparts (p0.05. Conclusion: Concomitant using of TrPPR therapy and KT method can decrease pain intensity in individuals with PFPS. Further studies are required to understand the underlying mechanisms.

  4. Cycling above rather than below lactate threshold is more effective for nitric oxide release and post-exercise blood pressure reduction in individuals with type-2 diabetes

    Ricardo Yukio Asano


    Full Text Available The purposes of this study were to analyze and compare the effects of exercise performed in different intensities, above and below lactate threshold (LT on post-exercise blood pressure (BP and nitric oxide (NO responses in individuals with type 2 diabetes (T2D. For this, 11 T2D underwent the following sessions: 1 control session; 2 20-min of moderate cycling (80% LT; and 3 20-min of high intensity cycling (120%LT on a cycle ergometer. Plasma NO and BP measurements were carried out at rest and at 15 and 45 min of post-sessions. When compared to rest, only the exercise session performed at 120%LT elicited an increase of NO (from 7.2 to 9.5 µM, p<0.05, as well as a decrease in systolic BP (from 126.6±7.9 to 118.7±3.9 mmHg, p<0.05 during the post-exercise period. In conclusion, the results suggest that NO release and post-exercise BP decrease are intensity-dependent for individuals with T2D.

  5. Add-on-Statin Extended Release Nicotinic Acid/Laropiprant but Not the Switch to High-Dose Rosuvastatin Lowers Blood Pressure: An Open-Label Randomized Study

    Anastazia Kei


    Full Text Available Introduction. Nicotinic acid (NA and statins have been associated with reductions in blood pressure (BP. Patients and Methods. We recruited 68 normotensive and hypertensive dyslipidemic patients who were treated with a conventional statin dose and had not achieved lipid targets. Patients were randomized to switch to high-dose rosuvastatin (40 mg/day or to add-on current statin treatment with extended release (ER NA/laropiprant (1000/20 mg/day for the first 4 weeks followed by 2000/40 mg/day for the next 8 weeks for 3 months. Results. Switching to rosuvastatin 40 mg/day was not associated with significant BP alterations. In contrast, the addition of ER-NA/laropiprant to current statin treatment resulted in a 7% reduction of systolic BP (from 134±12 to 125±10 mmHg, <.001 versus baseline and =.01 versus rosuvastatin group and a 5% reduction of diastolic BP (from 81±9 to 77±6 mmHg, =.009 versus baseline and =.01 versus rosuvastatin group. These reductions were significant only in the subgroup of hypertensives and were independent of the hypolipidemic effects of ER-NA/laropiprant. Conclusions. Contrary to the switch to high-dose rosuvastatin, the addition of ER-NA/laropiprant to statin treatment was associated with significant reductions in both systolic and diastolic BP.

  6. Effects of Blood Pressure and Blood Pressure-Lowering Treatment During the First 24 Hours Among Patients in the Third International Stroke Trial of Thrombolytic Treatment for Acute Ischemic Stroke.

    Berge, Eivind; Cohen, Geoffrey; Lindley, Richard I; Sandercock, Peter; Wardlaw, Joanna M; Sandset, Else C; Whiteley, William


    In patients with acute ischemic stroke, a high blood pressure or a highly variable blood pressure is a common reason for withholding thrombolytic treatment, but guidelines recommend a conservative approach to active blood pressure lowering in this setting. We have performed exploratory analyses to study the clinical effects of blood pressure and early blood pressure-lowering treatment in patients included in a randomized-controlled trial of thrombolytic treatment for acute ischemic stroke. The Third International Stroke Trial (IST-3) randomized 3035 patients with ischemic stroke to recombinant tissue-type plasminogen activator 0.9 mg/kg or open control within 6 hours of symptom onset. Blood pressure was measured at randomization, at start of treatment, and at 30 minutes and 1 and 24 hours after start of treatment, and the use of blood pressure-lowering treatment during the first 24 hours was recorded. We have characterized blood pressure by mean systolic blood pressure at baseline, by variability of systolic blood pressure (expressed by the standard deviation and the range between the lowest and the highest pressure), and by the change in systolic blood pressure from baseline to 24 hours. We used logistic regression analysis to explore the associations of blood pressure characteristics or blood pressure-lowering treatment with early adverse events, early death, and functional outcome at 6 months, after adjustment for key prognostic variables. High baseline blood pressure and high blood pressure variability during the first 24 hours were associated with higher numbers of early adverse events and early deaths, and for several analyses, the differences were statistically significant. A larger decline in blood pressure and the use of blood pressure-lowering treatment during the first 24 hours were associated with a reduced risk of poor outcome at 6 months (odds ratio, 0.93; 95% confidence interval, 0.89-0.97; P=0.001 and odds ratio, 0.78; 95% confidence interval, 0

  7. Renin release

    Schweda, Frank; Friis, Ulla; Wagner, Charlotte;


    The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located......, salt, and volume overload. In contrast, the events controlling the function of renin-secreting cells at the organ and cellular level are markedly less clear and remain mysterious in certain aspects. The unravelling of these mysteries has led to new and interesting insights into the process of renin...

  8. Multiphase Transport in Porous Media: Gas-Liquid Separation Using Capillary Pressure Gradients International Space Station (ISS) Flight Experiment Development

    Wheeler, Richard R., Jr.; Holtsnider, John T.; Dahl, Roger W.; Deeks, Dalton; Javanovic, Goran N.; Parker, James M.; Ehlert, Jim


    Advances in the understanding of multiphase flow characteristics under variable gravity conditions will ultimately lead to improved and as of yet unknown process designs for advanced space missions. Such novel processes will be of paramount importance to the success of future manned space exploration as we venture into our solar system and beyond. In addition, because of the ubiquitous nature and vital importance of biological and environmental processes involving airwater mixtures, knowledge gained about fundamental interactions and the governing properties of these mixtures will clearly benefit the quality of life here on our home planet. The techniques addressed in the current research involving multiphase transport in porous media and gas-liquid phase separation using capillary pressure gradients are also a logical candidate for a future International Space Station (ISS) flight experiment. Importantly, the novel and potentially very accurate Lattice-Boltzmann (LB) modeling of multiphase transport in porous media developed in this work offers significantly improved predictions of real world fluid physics phenomena, thereby promoting advanced process designs for both space and terrestrial applications.This 3-year research effort has culminated in the design and testing of a zero-g demonstration prototype. Both the hydrophilic (glass) and hydrophobic (Teflon) media Capillary Pressure Gradient (CPG) cartridges prepared during the second years work were evaluated. Results obtained from ground testing at 1-g were compared to those obtained at reduced gravities spanning Martian (13-g), Lunar (16-g) and zero-g. These comparisons clearly demonstrate the relative strength of the CPG phenomena and the efficacy of its application to meet NASAs unique gas-liquid separation (GLS) requirements in non-terrestrial environments.LB modeling software, developed concurrently with the zero-g test effort, was shown to accurately reproduce observed CPG driven gas-liquid separation

  9. Blood pressure control with a single-pill combination of indapamide sustained-release and amlodipine in patients with hypertension: the EFFICIENT study.

    Uday Jadhav

    Full Text Available OBJECTIVE: Despite antihypertensive treatment, most hypertensive patients still have high blood pressure (BP, notably high systolic blood pressure (SBP. The EFFICIENT study examines the efficacy and acceptability of a single-pill combination of sustained-release (SR indapamide, a thiazide-like diuretic, and amlodipine, a calcium channel blocker (CCB, in the management of hypertension. METHODS: Patients who were previously uncontrolled on CCB monotherapy (BP≥140/90 mm Hg or were previously untreated with grade 2 or 3 essential hypertension (BP≥160/100 mm Hg received a single-pill combination tablet containing indapamide SR 1.5 mg and amlodipine 5 mg daily for 45 days, in this multicenter prospective phase 4 study. The primary outcome was mean change in BP from baseline; percentage of patients achieving BP control (BP<140/90 mm Hg was a secondary endpoint. SBP reduction (ΔSBP versus diastolic BP reduction (ΔDBP was evaluated (ΔSBP/ΔDBP from baseline to day 45. Safety and tolerability were also assessed. RESULTS: Mean baseline BP of 196 patients (mean age 52.3 years was 160.2/97.9 mm Hg. After 45 days, mean SBP decreased by 28.5 mm Hg (95% CI, 26.4 to 30.6, while diastolic BP decreased by 15.6 mm Hg (95% CI, 14.5 to 16.7. BP control (<140/90 mm Hg was achieved in 85% patients. ΔSBP/ΔDBP was 1.82 in the overall population. Few patients (n = 3 [2%] reported side effects, and most (n = 194 [99%] adhered to treatment. CONCLUSION: In patients who were previously uncontrolled on CCB monotherapy or untreated with grade 2 or 3 hypertension, single-pill combination indapamide SR/amlodipine reduced BP effectively--especially SBP--over 45 days, and was safe and well tolerated. TRIAL REGISTRATION: Clinical Trial Registry-India CTRI/2010/091/000114.

  10. First-principles calculations of high-pressure iron-bearing monoclinic dolomite and single-cation carbonates with internally consistent Hubbard U

    Solomatova, Natalia V.; Asimow, Paul D.


    It has been proposed that iron has a significant effect on the relative stability of carbonate phases at high pressures, possibly even stabilizing double-cation carbonates (e.g., dolomite) with respect to single-cation carbonates (e.g., magnesite, aragonite and siderite). X-ray diffraction experiments have shown that dolomite transforms at 35 GPa to a high-pressure polymorph that is stable to decomposition; however, there has been disagreement on the structure of the high-pressure phase (Mao et al. in Geophys Res Lett 38, 2011. doi: 10.1029/2011GL049519; Merlini et al. in Proc Natl Acad Sci 109:13509-13514, 2012. doi: 10.1073/pnas.1201336109). Ab initio calculations interfaced with an evolutionary structure prediction algorithm demonstrated that a C2/c polymorph of pure CaMg(CO3)2 dolomite is more stable than previously reported structures (Solomatova and Asimow in Am Mineral 102:210-215, 2017, doi: 10.2138/am-2017-5830). In this study, we calculate the relative enthalpies up to 80 GPa for a set of carbonate phases including Fe-bearing solutions and endmembers, using the generalized gradient approximation and a Hubbard U parameter calculated through linear response theory to accurately characterize the electronic structure of Fe. When calculated with a constant U of 4 eV, the spin transition pressure of (Mg,Fe)CO3 agrees well with experiments, whereas an internally consistent U overestimates the spin transition pressure by 50 GPa. However, whether we use constant or internally consistent U values, a higher iron concentration increases the stability field of dolomite C2/c with respect to single-cation carbonate assemblages, but iron-free dolomite is not stable with respect to single-cation carbonates at any pressure. Thus, high-pressure polymorphs of Fe-bearing dolomite could in fact represent an important reservoir for carbon storage within oxidized sections of Earth's mantle.

  11. Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome*.

    Yehya, Nadir; Topjian, Alexis A; Thomas, Neal J; Friess, Stuart H


    Children with an immunocompromised condition and requiring invasive mechanical ventilation have high risk of death. Such patients are commonly transitioned to rescue modes of nonconventional ventilation, including airway pressure release ventilation and high-frequency oscillatory ventilation, for acute respiratory distress syndrome refractory to conventional ventilation. Our aim was to describe our experience with airway pressure release ventilation and high-frequency oscillatory ventilation in children with an immunocompromised condition and acute respiratory distress syndrome refractory to conventional ventilation and to identify factors associated with survival. Retrospective cohort study. Tertiary care, university-affiliated PICU. Sixty pediatric patients with an immunocompromised condition and acute respiratory distress syndrome refractory to conventional ventilation transitioned to either airway pressure release ventilation or high-frequency oscillatory ventilation. None. Demographic data, ventilator settings, arterial blood gases, oxygenation index, and PaO(2)/FIO(2) were recorded before transition to either mode of nonconventional ventilation and at predetermined intervals after transition for up to 5 days. Mortality in the entire cohort was 63% and did not differ between patients transitioned to airway pressure release ventilation and high-frequency oscillatory ventilation. For both airway pressure release ventilation and high-frequency oscillatory ventilation, improvements in oxygenation index and PaO(2)/FIO(2) at 24 hours expressed as a fraction of pretransition values (oxygenation index(24)/oxygenation index(pre) and PaO(2)/FIO(224)/PaO(2)/FIO(2pre)) reliably discriminated nonsurvivors from survivors, with receiver operating characteristic areas under the curves between 0.89 and 0.95 (p for all curves high-frequency oscillatory ventilation were less than 5% reduction in oxygenation index (100% sensitive, 83% specific) or less than 80% increase in PaO(2

  12. Validation of Omron RS8, RS6, and RS3 home blood pressure monitoring devices, in accordance with the European Society of Hypertension International Protocol revision 2010

    Takahashi H


    Full Text Available Hakuo Takahashi, Masamichi Yoshika, Toyohiko YokoiDepartment of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Hirakata, Osaka, JapanBackground: Allowing patients to measure their blood pressure at home is recognized as being of clinical value. However, it is not known how often these measurements are taken correctly. Blood pressure monitors for home use fall into two types based on the position of the cuff, ie, at the upper arm or the wrist. The latter is particularly convenient, as measurements can be taken fully clothed. This study aimed to evaluate the performance of the wrist-type blood pressure monitors Omron RS8 (HEM-6310F-E, Omron RS6 (HEM-6221-E, and Omron RS3 (HEM-6130-E.Methods: A team of three trained doctors validated the performance of these devices by comparing the measurements obtained from these devices with those taken using a standard mercury sphygmomanometer. All the devices met the validation requirements of the European Society of Hypertension International Protocol revision 2010.Results: The difference in blood pressure readings between the tested device and the standard mercury sphygmomanometer was within 3 mmHg, which is acceptable according to the European Society of Hypertension guidelines.Conclusion: All the home devices tested were found to be suitable for measuring blood pressure at home because their performance fulfilled the requirement of the guidelines.Keywords: blood pressure, device, European Society of Hypertension, guideline, measurement, validation

  13. Evidence-based recommendations for negative pressure wound therapy: treatment variables (pressure levels, wound filler and contact layer)--steps towards an international consensus.

    Birke-Sorensen, H; Malmsjo, M; Rome, P; Hudson, D; Krug, E; Berg, L; Bruhin, A; Caravaggi, C; Chariker, M; Depoorter, M; Dowsett, C; Dunn, R; Duteille, F; Ferreira, F; Francos Martínez, J M; Grudzien, G; Ichioka, S; Ingemansson, R; Jeffery, S; Lee, C; Vig, S; Runkel, N; Martin, R; Smith, J


    Negative pressure wound therapy (NPWT) is becoming a commonplace treatment in many clinical settings. New devices and dressings are being introduced. Despite widespread adoption, there remains uncertainty regarding several aspects of NPWT use. To respond to these gaps, a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In a previous communication, we have reviewed the evidence base for the use of NPWT within trauma and reconstructive surgery. In this communication, we present results of the assessment of evidence relating to the different NPWT treatment variables: different wound fillers (principally foam and gauze); when to use a wound contact layer; different pressure settings; and the impact of NPWT on bacterial bioburden. Evidence-based recommendations were obtained by a systematic review of the literature, grading of evidence and drafting of the recommendations by a global expert panel. Evidence and recommendations were graded according to the Scottish Intercollegiate Guidelines Network (SIGN) classification system. In general, there is relatively weak evidence on which to base recommendations for any one NPWT treatment variable over another. Overall, 14 recommendations were developed: five for the choice of wound filler and wound contact layer, four for choice of pressure setting and five for use of NPWT in infected wounds. With respect to bioburden, evidence suggests that reduction of bacteria in wounds is not a major mode of action of NPWT.

  14. Manipulation of reproductive performance of lactating buffaloes using melatonin and controlled internal drug release device treatment during out-of-breeding season under tropical conditions.

    Ramadan, T A; Sharma, R K; Phulia, S K; Balhara, A K; Ghuman, S S; Singh, I


    Twelve lactating Murrah buffalo, divided into control and treatment group of six animals each, were used to study the effect of melatonin and controlled internal drug release (CIDR) device treatment on the resumption of ovarian activity during out-of-breeding season (summer solstice). Treated group implanted with melatonin (18-mg melatonin/50-kg body weight) for 45 days and then animals of both groups received CIDR for 9 days. All animals received intramuscular 500 IU eCG, at day before CIDR removal, and 10-μg GnRH at day after CIDR withdrawal. All animals were subjected to estrus detection daily. Blood samples in conjunction with transrectal ultrasonography were performed once a week to determine serum concentrations of melatonin, progesterone, and antioxidant enzyme activities, as well as to monitor the ovarian activity. Melatonin treatment resulted in an increase (P < 0.01) in the overall mean superoxide dismutase activity. Melatonin and CIDR increased the diameter of CL (P < 0.01) and plasma progesterone concentration (P < 0.05). In addition, melatonin and CIDR exhibited superior ability to maintain presence of CL at Day 21 and Day 30 after artificial insemination and achieved higher percentage of conception rate than control. In conclusion, the CIDR treatment preceded by melatonin improved the reproductive performance in lactating buffaloes during out-of-breeding season under tropical conditions.

  15. Body satisfaction, thin-ideal internalization, and perceived pressure to be thin among Canadian women: The role of acculturation and religiosity.

    Chaker, Zina; Chang, Felicia M; Hakim-Larson, Julie


    In an online study, 143 Canadian women of various religious backgrounds completed measures of acculturation, religiosity, body satisfaction, internalization of the thin ideal, perceived pressure from media, and manner of dress. Heritage acculturation correlated with appearance satisfaction, but not weight satisfaction. After accounting for BMI and social desirability, higher heritage acculturation and lower mainstream acculturation were associated with lower perceived pressure from media. Thus, heritage acculturation across religious denominations may serve as a buffer against appearance dissatisfaction and perceived media pressure. Manner of dress among the Muslim subgroup and its relation to religiosity and acculturation were also assessed. Muslim women who dressed in greater accordance with Islamic principles reported lower heritage acculturation and greater religiosity. Thus, Muslim women's manner of dress was related to their religiosity and the extent to which they embraced cultural values. These findings are discussed in terms of the possible distinctions between heritage acculturation and religiosity.

  16. Experiment of internal pressure response characteristics excited by sinusoidal external pressure for rigid structure with opening%正弦波激励下刚性开孔结构内压响应特性实验

    余世策; 李庆祥; 俞海峰; 吕江; 王彤


    利用声音振动发生原理研制了专门用于内压机理研究的实验装置,对单一开孔的刚性结构在正弦波气压激励下的内压动力特性进行了多参数对比实验.实验研究结果表明:开孔结构在外部动压力作用下会发生腔体共振,随开孔面积增大,腔体共振频率增大阻尼比减小;随孔口深度及内部容积增大,腔体共振频率减小阻尼比增大;对于深宽比很小且开孔面积相同的孔口,孔口形状对腔体共振频率影响不大,对阻尼比有一定影响.%A special experimental device was developed for researching internal pressure mechanism by using principle of sound vibrations, and the multi-parameter comparative experiments were conducted to study the internal pressure response characteristics for rigid structure with single opening excited by sinusoidal external pressure. Experimental results show that cavity resonance occurs for structure with opening excited by dynamic external pressure. With the opening area increasing, the cavity resonance frequency increases and damping ratio decreases. With the orifice depth and internal volume increasing, the cavity resonance frequency decreases and the damping ratio increases. For the openings with small aspect ratio and the same opening area, orifice shape has little effect on the cavity resonance frequency but has some influence on damping ratio.

  17. Effect of external pressure environment on the internal noise level due to a source inside a cylindrical tank

    Clevenson, S. A.; Roussos, L. A.


    A small cylindrical tank was used to study the effect on the noise environment within a tank of conditions of atmospheric (sea level) pressure or vacuum environments on the exterior. Experimentally determined absorption coefficients were used to calculate transmission loss, transmissibility coefficients and the sound pressure (noise) level differences in the interior. The noise level differences were also measured directly for the two exterior environments and compared to various analytical approximations with limited agreement. Trend study curves indicated that if the tank transmission loss is above 25 dB, the difference in interior noise level between the vacuum and ambient pressure conditions are less than 2 dB.

  18. 利用卸压槽治理软岩巷道底鼓%Pressure Releasing Groove Applied to Floor Heave Control of Mine Sof t Rock Roadway

    郝建斌; 魏巍; 董长龙


    在建矿井奇台一矿主采B3煤层,厚度约22m ,埋深518~540m。中央辅助运输大巷沿煤层底板掘进。底板属极软岩,遇水易膨胀,出现底鼓现象。巷道掘进后,底板即鼓起,且速度较快,平均底鼓速度达10mm/d ,原采用常规浇筑混凝土底板的办法来加以治理,未获成功。后根据具体情况,在巷道底板中间开挖卸压槽,并采用反底拱支护方式来治理底鼓,效果良好,为软岩巷道底鼓治理提供了新的经验。%In a construction mine of Qitai No.1 mine ,a main mining seam was B3 seam ,a thickness of the seam was about 22m and a depth of the seam was 518~540m. A mine central auxiliary transporta‐tion roadway was headed along the seam floor. The seam floor was an ultra soft rock ,could be easily swelled with water and would cause a floor heave phenomenon.After the mine roadway headed ,the floor would be soon heaved ,the heave speed was fast and an average floor heave speed was 10mm/day. A previous conventional method with a site pouring concrete floor was applied to control the floor heave and the method was not success.Late ,according to the certain condition ,a pressure releasing groove was excavated in the middle of the mine roadway ,a reverse floor arch support method was ap‐plied to control the floor heave and excellent effect was obtained. Thus a new experience was provided to the floor heave control of the mine soft rock roadway.

  19. Alkali release and sorption during combustion and gasification of coal under pressure; Freisetzung und Einbindung von Alkalien bei der Verbrennung und Vergasung von Kohle unter Druck

    Steffin, C.R.; Wanzl, W.; Heek, K.H. van [DMT-Gesellschaft fuer Forschung und Pruefung mbH, Essen (Germany). Geschaeftsbereich FuelTec - Kokerei- und Brennstofftechnik


    Investigations and model calculations have shown that water-soluble alkaline substances (in German coal, mostly NaCl) are released by a desorption process rather than a purely physical evaporation process. Sorption takes place in the presence of reactive oxygen species (H{sub 2}O or O{sub 2}), but only the reaction with water vapour is applicable to technical processes. Soorption is preferred to desorption at low temperatures both kinetically and thermodynamically. Metakaolin has a high alkali sorption capacity and potential depending significantly on the chemical properties of the clay mineral. With increasing basicity, the sorption potential decreases drastically, which has a significant effect in terms of fuel selection and mode of operation of the process of coal dust combustion under pressure. A fuel with low alkali emissions would be a coal grade with a small fraction of water-soluble alkalis and a high fraction of acid clay minerals. Intensive scrubbing in a wet chemical treatment stage may serve to reduce the water-soluble alkalis. [Deutsch] Die Untersuchungen und Modellrechnungen haben gezeigt, dass die Freisetzung der wasserloeslichen Alkalien, was in deutschen Steinkohlen hauptsaechlich NaCl ist, ein Desorptionsmechanismus zugrunde liegt und die Vorstellung eines rein physikalischen Verdampfungsprozesses verworfen werden muss. Die Einbindung der Alkalien findet unter Teilnahme reaktiver Sauerstoffspezies (H{sub 2}O oder O{sub 2}) statt, wobei aber nur die Reaktion mit Wasserdampf auch auf technische Prozesse uebertragbar ist. Die Einbindung ist gegenueber der Desorption bei niedrigen Temperaturen kinetisch und thermodynamisch bevorzugt. Metakaolin besitzt eine hohe Kapazitaet und ein hohes Potential zur Einbindung von Alkalien, wobei die Faehigkeit zur Einbindung ganz entscheidend von den chemischen Eigenschaften des Tonminerals abhaengig ist. Mit steigender Basizitaet nimmt das Einbindungspotential der Mineralsubstanz drastisch ab. Das hat auch

  20. Impact of Dietary Acculturation on the Food Habits, Weight, Blood Pressure, and Fasting Blood Glucose Levels of International College Students

    Almohanna, Amal; Conforti, Frank; Eigel, William; Barbeau, William


    Objective: This study was conducted to determine the impact of dietary acculturation on the health status of newly arrived international students at Virginia Tech in Fall 2010. Participants: Thirty-five international students, 18-36 years of age, completed the study. Methods: Data were collected at 3 different time periods (V1, V2, and V3)…

  1. Drag with external and pressure drop with internal flows: a new and unifying look at losses in the flow field based on the second law of thermodynamics

    Herwig, Heinz; Schmandt, Bastian, E-mail: [Hamburg University of Technology, Institute for Thermo-Fluid Dynamics, Denickestr. 17, D-21073 Hamburg (Germany)


    Internal and external flows are characterized by friction factors and drag coefficients, respectively. Their definitions are based on pressure drop and drag force and thus are very different in character. From a thermodynamics point of view in both cases dissipation occurs which can uniformly be related to the entropy generation in the flow field. Therefore we suggest to account for losses in the flow field by friction factors and drag coefficients that are based on the overall entropy generation due to the dissipation in the internal and external flow fields. This second law analysis (SLA) has been applied to internal flows in many studies already. Examples of this flow category are given together with new cases of external flows, also treated by the general SLA-approach. (paper)

  2. 腕管内压测量及其临床意义%Carpal tunnel internal pressure measurement and its clinical significance

    罗特坚; 刘冬强; 全金海; 肖亮; 徐运碧; 伍日萍


    Objective To research into the etiology of carpal tunnel syndrome and seek for the best therapy. Methods The internal pressure of carpal tunnel above and under transverse carpal ligament were measured by blood pressure monitor and the thickness of transverse carpal ligament was observed. Results The internal pressure of carpal runnel was ( 1.39 ±1.14) mmHg and ( 1.81 ±0.72)mmHg above the ligament while it was (3.02 ± 1.12) mmHg and ( 3.15 ± 1.23 ) mmHg below the ligament. The thickness of transverse carpal ligament was (0.13 ±0.06)mm. No results of internal pressure could be detected by this blood pressure monitor after cutting off transverse carpal ligament. Conclusion The internal pressure of carpal tunnel is connected with the thickness of transverse carpal ligament. The factor that makes transverse carpal ligament thicker is one of the inducing factors of carpal tunnel syndrome.%目的探讨腕管综合症的发病原因,寻找治疗腕管综合症的最佳方法.方法利用通过造改的血压测量器,测量腕管在碗横韧带上、下方的内压;观察测量腕横韧带的厚度.结果腕管内压力在韧带上方左侧为(1.39±1.14)mmHg,右侧为(1.81±0.72)mmHg,在韧带下方左侧为(3.02±1.12)mmHg,右侧为(3.15±1.23)mmHg;腕横韧带的厚度为(0.13±0.06)mm.切断腕横韧带后用此种压力测量器尚未测出腕管内压.结论腕管内压的维持与腕横韧带的厚度有一定关系,某种因素造成腕横韧带的增厚是腕管综合症的发病原因之一.

  3. An atmospheric pressure chemical ionization-ion-trap mass spectrometer for the on-line analysis of volatile compounds in foods: a tool for linking aroma release to aroma perception.

    Le Quéré, Jean-Luc; Gierczynski, Isabelle; Sémon, Etienne


    An atmospheric pressure chemical ionization ion-trap mass spectrometer was set up for the on-line analysis of aroma compounds. This instrument, which has been successfully employed for some years in several in vitro and in vivo flavour release studies, is described for the first time in detail. The ion source was fashioned from polyether ether ketone and operated at ambient pressure and temperature making use of a discharge corona pin facing coaxially the capillary ion entrance of the ion-trap mass spectrometer. Linear dynamic ranges (LDR), limits of detection (LOD) and other analytical characteristics have been re-evaluated. LDRs and LODs have been found fully compatible with the concentrations of aroma compounds commonly found in foods. Thus, detection limits have been found in the low ppt range for common flavouring aroma compounds (for example 5.3 ppt (0.82 ppbV) for ethyl hexanoate and 4.8 ppt (1.0 ppbV) for 2,5-dimethylpyrazine). This makes the instrument applicable for in vitro and in vivo aroma release investigations. The use of dynamic sensory techniques such as the temporal dominance of sensations (TDS) method conducted simultaneously with in vivo aroma release measurements allowed to get some new insights in the link between flavour release and flavour perception.

  4. The effect of a trunk release maneuver on Peak Pressure Index, trunk displacement and perceived discomfort in older adults seated in a High Fowler's position: a randomized controlled trial.

    Best, Krista L; Desharnais, Guylaine; Boily, Jeanette; Miller, William C; Camp, Pat G


    Pressure ulcers pose significant negative individual consequences and financial burden on the healthcare system. Prolonged sitting in High Fowler's position (HF) is common clinical practice for older adults who spend extended periods of time in bed. While HF aids in digestion and respiration, being placed in a HF may increase perceived discomfort and risk of pressure ulcers due to increased pressure magnitude at the sacral and gluteal regions. It is likely that shearing forces could also contribute to risk of pressure ulcers in HF. The purpose of this study was to evaluate the effect of a low-tech and time-efficient Trunk Release Manuever (TRM) on sacral and gluteal pressure, trunk displacement and perceived discomfort in ambulatory older adults. A randomized controlled trial was used. We recruited community-living adults who were 60 years of age and older using posters, newspaper advertisements and word-of-mouth. Participants were randomly allocated to either the intervention or control group. The intervention group (n = 59) received the TRM, while the control group (n = 58) maintained the standard HF position. The TRM group had significantly lower mean (SD) PPI values post-intervention compared to the control group, 59.6 (30.7) mmHg and 79.9 (36.5) mmHg respectively (p = 0.002). There was also a significant difference in trunk displacement between the TRM and control groups, +3.2 mm and -5.8 mm respectively (p = 0.005). There were no significant differences in perceived discomfort between the groups. The TRM was effective for reducing pressure in the sacral and gluteal regions and for releasing the trunk at the point of contact between the skin and the support surface, but did not have an effect on perceived discomfort. The TRM is a simple method of repositioning which may have important clinical application for the prevention of pressure ulcers that may occur as a result of HF.

  5. Comparison of pregnancy rates in beef cattle after a fixed-time AI with once- or twice-used controlled internal drug release devices.

    Muth-Spurlock, A M; Poole, D H; Whisnant, C S


    The use of fixed-time artificial insemination (FTAI) provides producers with numerous benefits including the use of superior genetics, shorter breeding and calving seasons, and a more uniform calf crop. However, the cost of implementing FTAI protocols is one of the several drawbacks hindering their use in the beef industry. Potential injection-site lesions from intramuscular injections of the hormones necessary for estrus synchronization are also a cause of concern for carcass quality. The objectives of this experiment were to (1) determine whether or not a twice-used controlled internal drug release (CIDR) device would be effective in an FTAI protocol without adversely affecting pregnancy rate and (2) whether or not the subcutaneous administration of PGF2α affects pregnancy rate. Nulliparous females (n = 99) between 13 and 27 months of age and multiparous cows (n = 43) between 48 and 74 months of age were synchronized for estrus using the 7-day CO-Synch + CIDR protocol. The females were randomly assigned to one of the two treatments: (1) a once-used CIDR (control) or (2) a twice-used CIDR device (treatment) incorporated into their synchronization protocol. The females were also randomly assigned to have their injection of PGF2α administered either intramuscularly or subcutaneously. Blood was taken in a random subset of nulliparous females (n = 52) just before device removal and assayed for concentration of progesterone. The concentration of progesterone was higher (P = 0.01) in the animals that received once-used CIDR devices than that in those received twice-used CIDR devices (3.4 ± 0.5 and 1.4 ± 0.5 ng/mL, respectively). There was no significant effect of parity (P = 0.82), artificial insemination technician (P = 0.60), PGF2α administration (P = 0.83), or treatment (P = 0.67) on pregnancy rates to artificial insemination which were 75.4 ± 6.0% and 71.7 ± 6.4%, for animals that received once- and twice-used CIDR devices, respectively. This study provides

  6. 蒸气压对聚合物包膜肥料氮素释放特性的影响%Influence of Vapor Pressure on the Nitrogen Release of Polymer-coated Fertilizers

    陈可可; 张保林; 侯翠红


    为了从微观和动力学的角度揭示聚合物包膜肥料氮素释放的机理,研究了不同介质的蒸汽压对国内外生产工艺、养分释放机理不相同的4种聚合物包膜肥料中的氮素释放特性的影响。结果表明:在水、KH2PO4饱和溶液、KCl 饱和溶液3种介质蒸汽压下,4种供试肥料的氮素累积释放率均为:H2O>KH2PO4饱和溶液>KCl饱和溶液,利用一级动力学方程和Arrhenius方程联合得出3种介质蒸汽压下4种供试肥料的氮素释放活化能依次为:H2O<KH2PO4饱和溶液<KCl饱和溶液。缓/控释肥料的氮素累积释放率随包膜层内外的蒸汽压差增大而增大,包膜材料、肥料核心养分类型均影响肥料养分的释放。%In order to reveal the mechanism of nitrogen release of polymer-coated fertilizers, the N release characteristic from 4 polymer-coated fertilizers which have different produce technics and nutrition release mechanism was investigated in this paper. The results showed that: based on the experiments of nitrogen release under different vapor pressure, the cumulate release rate of nitrogen from polymer-coated fertilizers was: H2O > saturated solution of KH2PO4 > saturated solution of KCl; the nitrogen release activation energy from polymer-coated fertilizers was: H2O < saturated solution of KH2PO4 < saturated solution of KCl. The cumulate release rate of nitrogen from polymer-coated fertilizers increased as the difference between vapor pressure in or out integument increasing, and both the coated materials and the types of nutrient affected the release rate of nitrogen release from fertilizers.


    SONG, B.; MARVIZÓN, J. C. G.


    Endogenous opioids in the spinal cord play an important role in nociception, but the mechanisms that control their release are poorly understood. To simultaneously detect all opioids able to activate the μ-opioid receptor, we measured μ-opioid receptor internalization in rat spinal cord slices stimulated electrically or chemically to evoke opioid release. Electrical stimulation of the dorsal horn in the presence of peptidase inhibitors produced μ-opioid receptor internalization in half of the μ-opioid receptor neurons. This internalization was rapidly abolished by N-methyl-d-aspartate (IC50=2 μM), and N-methyl-d-aspartate antagonists prevented this effect. μ-Opioid receptor internalization evoked by high K+ or veratridine was also inhibited by N-methyl-d-aspartate receptor activation. N-methyl-d-aspartate did not affect μ-opioid receptor internalization induced by exogenous endomorphins, confirming that the effect of N-methyl-d-aspartate was on opioid release. We hypothesized that this inhibition was mediated by large conductance Ca2+-sensitive K+ channels BK(Ca2+). Indeed, inhibition by N-methyl-d-aspartate was prevented by tetraethylammonium and by the selective BK(Ca2+) blockers paxilline, penitrem A and verruculogen. Paxilline did not increase μ-opioid receptor internalization in the absence of N-methyl-d-aspartate, indicating that it does not produce an increase in opioid release unrelated to the inhibition by N-methyl-d-aspartate. The BK(Ca2+) involved appears to be a subtype with slow association kinetics for iberiotoxin, which was effective only with long incubations. The BK(Ca2+) opener NS-1619 also inhibited the evoked μ-opioid receptor internalization, and iberiotoxin prevented this effect. We concluded that Ca2+ influx through N-methyl-d-aspartate receptors causes the opening of BK(Ca2+) and hyperpolarization in opioid-containing dorsal horn neurons, resulting in the inhibition of opioid release. Since μ-opioid receptors in the dorsal horn

  8. N-methyl-D-aspartate receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce mu-opioid receptor internalization in the rat spinal cord.

    Song, B; Marvizón, J C G


    Endogenous opioids in the spinal cord play an important role in nociception, but the mechanisms that control their release are poorly understood. To simultaneously detect all opioids able to activate the mu-opioid receptor, we measured mu-opioid receptor internalization in rat spinal cord slices stimulated electrically or chemically to evoke opioid release. Electrical stimulation of the dorsal horn in the presence of peptidase inhibitors produced mu-opioid receptor internalization in half of the mu-opioid receptor neurons. This internalization was rapidly abolished by N-methyl-D-aspartate (IC50=2 microM), and N-methyl-D-aspartate antagonists prevented this effect. mu-Opioid receptor internalization evoked by high K+ or veratridine was also inhibited by N-methyl-D-aspartate receptor activation. N-methyl-D-aspartate did not affect mu-opioid receptor internalization induced by exogenous endomorphins, confirming that the effect of N-methyl-D-aspartate was on opioid release. We hypothesized that this inhibition was mediated by large conductance Ca2+-sensitive K+ channels BK(Ca2+). Indeed, inhibition by N-methyl-D-aspartate was prevented by tetraethylammonium and by the selective BK(Ca2+) blockers paxilline, penitrem A and verruculogen. Paxilline did not increase mu-opioid receptor internalization in the absence of N-methyl-D-aspartate, indicating that it does not produce an increase in opioid release unrelated to the inhibition by N-methyl-d-aspartate. The BK(Ca2+) involved appears to be a subtype with slow association kinetics for iberiotoxin, which was effective only with long incubations. The BK(Ca2+) opener NS-1619 also inhibited the evoked mu-opioid receptor internalization, and iberiotoxin prevented this effect. We concluded that Ca2+ influx through N-methyl-D-aspartate receptors causes the opening of BK(Ca2+) and hyperpolarization in opioid-containing dorsal horn neurons, resulting in the inhibition of opioid release. Since mu-opioid receptors in the dorsal horn

  9. The efficacy of controlled internal drug release (CIDR) in synchronizing the follicular wave in dromedary camels (Camelus dromedarius) during the breeding season.

    Swelum, Ayman Abdel-Aziz; Alowaimer, Abdullah Nasser


    The present study aimed to evaluate the efficacy of controlled internal drug release (CIDR) to synchronize the follicular wave in dromedary camels (Camelus dromedarius) during the breeding season through ovarian monitoring, evaluating sexual receptivity, and measuring progesterone (P4) and estradiol (E2) levels during and after CIDR treatment. Sixteen camels received a new CIDR containing 1.9 g of P4 for 14 days. Ultrasound ovarian monitoring was performed on the day of insertion and every 3 days until the CIDR was withdrawn. Ultrasound examinations were continued day in day out after the CIDR was withdrawn for 10 days. According to the ultrasound examinations, the percentages of camels in the breeding (follicles: 12-18 mm) and nonbreeding phases were calculated. Blood samples were collected day after day during the experimental period (24 days) from the day that the CIDR was inserted. The serum P4 and E2 concentrations were analyzed using ELISA kits. The sexual receptivity of the camels was tested daily during the course of the experiment. The results revealed that 2 and 4 days after the CIDR was withdrawn, the percentage of camels in the breeding phase (68.75% and 75.00%, respectively) was significantly (P dromedary camels. In conclusion, the treatment of dromedary camels with CIDR produced a uniform increase in serum concentrations of P4 that could completely prevent sexual receptivity but could not suppress the follicular wave. After CIDR withdrawal, the P4 levels fell and induced the emergence of a new follicular wave, and most of the camels were in the breeding (ovulatory) phase 2 to 4 days after withdrawal. Therefore, CIDR can be used to synchronize the follicular wave in dromedary camels.

  10. Lipopolysaccharide Could Be Internalized into Human Peripheral Blood Mononuclear Cells and Elicits TNF-α Release,but not via the Pathway of Toll-Like Receptor 4 on the Cell Surface

    HongZhou; GuofuDing; WeiLiu; LiangxiWang; YonglingLu; HongweiCao; JiangZheng


    Lipopolysaccharide (LPS [endotoxin]), the principal component of the outer membrane of gram-negative bacteria, stimulate various cell types to release numerous proinflammatory mediators such as TNF-α, IL-6 and IL-12, which may damage cells and lead to organ injury, even sepsis and septic shock. Toll-like receptor 4(TLR4) has been identified as the receptor involved in the recognition of LPS, but the role of LPS uptake inactivating signal transduction remains controversial. In the present study, TNF-α was used as a marker of macrophages/monocytes activated by LPS, and CQ was used as an inhibitor of endosome mature in order to definitude what stage the signal transduction elicited by LPS was interrupted. We found that there indeed existed internalization of LPS and internalization partially participated in LPS signaling since CQ inhibitedcytokine release, and decreased accumulation of FITC-LPS in hPBMC. In contrast, anti-hTLR4 antibodycould decrease cytokines' release, but no inhibition on accumulation of FITC-LPS. This result revealed thatinhibition of cytokine release was related to reduction of FITC-LPS accumulation in the cells. But TLR4 on thecell surface didn't possibly participated in internalization of LPS. Thus, LPS signaling and internalizationcannot be viewed as mutually independent processes. Cellular & Molecular Immunology. 2004;1(5):373-377.

  11. Numerical investigation on the effect of injection pressure on the internal flow characteristics for diethyl ether, dimethyl ether and diesel fuel injectors using CFD

    Vijayakumar Thulasi


    Full Text Available The spray characteristics of the diesel fuel are greatly affected by the cavitation formed inside the injector due to the high pressure differential across the nozzle. Many researchers across the globe are exploring the potential of using diethyl ether and dimethyl ether as an alternate for diesel fuel to meet the strict emission norms. Due to the variation in the fuel properties the internal flow characteristics in injectors for ether fuels are expected to be different from that of the diesel fuel. In this paper computational technique is used to study and compare the internal flow characteristics of diethyl ether, dimethyl ether and diesel fuel. The two phase flow model considering the fuel as a mixture of liquid and vapor is adopted for the simulation study. The injection pressure is varied from 100 to 400 bar and the flow characteristics of all three fuels are simulated and compared. Results indicate that all three fuels have distinct cavitating patterns owing to different property values. The dimethyl ether is found to be more cavitating than diesel and diethyl ether fuels as expected. The mass of fuel injected are found to be decreasing for the ether fuels when compared with diesel fuel at all injection pressures.

  12. CONFERENCE NOTE: Comité Consultatif pour la Masse et les grandeurs apparentées (CCM), High Pressure and Medium Pressure Working Groups, Second International Seminar on Pressure Metrology from 1 kPa to 1 GPa


    The seminar will be held from 2 to 4 June 1993, preceding the next meeting of the CCM, at the Laboratoire National d'Essais (LNE), 1 rue Gaston Boissier, 75015 Paris, France. Scope of the Seminar The purpose of the seminar is to review the state of the art of pressure measurements in the 1 kPa to 1 GPa range and to present original and innovative contributions from standards laboratories and industry. Main Topics The seminar will be organized in six sessions as follows: Liquid-column manometers Piston gauge pressure standards Properties of liquids and gases relevant to pressure metrology Pressure transducers and transfer standards Pressure standard comparison (methods and results) Dynamic pressure measurements. Each topic will be introduced by a review paper presented by a session chairman. A final session, coordinated by Dr G F Molinar (IMGC), Chairman of the CCM High Pressure Working Group, and Dr P Stuart (NPL), Chairman of the CCM Medium Pressure Working Group, will deal with: Actual limits of accuracy of static pressure measurements in fluid media Fundamental problems in pressure metrology between I kPa and 1 GPa. Call for Papers Papers should be prepared for oral presentation and will be refereed by the session chairmen. The Proceedings will be published as a special issue of Metrologia. Papers should be written according to the instructions for authors printed on the inside back cover of this journal. A one-page abstract should be sent to Dr Molinar at the IMGC, to arrive before 31 January 1993. A participation fee of 900 FFr (175 US) will be charged. This will cover general expenses and a copy of the Proceedings. Hotel reservations, meals and transport are not included. Organizers For further information please contact: 1993 CCM Pressure Seminar, Dr G F Molinar, Istituto di Metrologia "G Colonnetti", Strada delle Cacce 73, 1-10135 Torino, Italy telephone (39) 11 39771; telex 212209 IMGCTO-I; fax (39) 11 346761. Contact at the LNE: J C Legras, telephone (33

  13. 内水相结构对微球包封率及控释行为的影响%Influences of Microparticle Internal Phase on Hydrophilic Drug Loading Efficiency and Releasing

    陈龙; 李红; 邓春林; 何显运; 魏坤; 吴刚


    Poly(lactic-co-glycolic acid) (PLGA) microspheres containing ofloxacine were made using the double-emulsion ( water-in-oil-in-water) solvent extraction/evaporation method. The influences of mesoporous silica, hyaluronic acid, polylysine in internal aqueous solution on the microparticle size distribution, surface morphology, ofloxacine loading efficiency and release behavior were investigated. SEM pictures indicate that microparticles with the microcavities inside are fabricated. The average particle size of Haluronic acid (HA) internal phase group is largest and the span index is smallest. Loading efficiency increases in both mesoporous silica (MS) and HA internal phase groups but decreases in polylysine group. The burst release of all groups is higher than that of the control group. Releasing profiles present the release rates of polylysine internal phase microparticle is fastest, while HA internal phase microparticles present the slowest release rates. The fit curves of the drug release pattern of the microparticles with different internal phases accord with the Slogistic mathematic mode.%采用水-油-水双乳化溶剂挥发法制备了聚乳酸-羟基乙酸共聚物(PLGA)/氧氟沙星载药微球,并考察了介孔硅、透明质酸、多聚赖氨酸不同内水相成分对微球粒径及其分布、表面形态、包封率以及释放特性的影响.研究结果表明,采用该方法制备出了内部具有多孔结构的载药微球;透明质酸内水相组微球平均粒度最大,粒径分布最小;介孔硅和透明质酸的加入提高了微球包封率;3种内水相组的初期爆释均高于对照组;多聚赖氨酸内水相组释放速率最快,透明质酸内水相组释放速率最慢.释放拟合曲线表明,4组不同内水相的微球,在释放区间内,释放行为都符合Slogistic方程式.

  14. Stress State of Elastic Thick-Walled Ring With Self-Balanced Pressures Distributed on Its Internal and External Borders

    Kravchuk Aleksandr Stepanovich


    Full Text Available For the first time with the help of the theory of analytic functions and Kolosov-Muskhelishvili formulas the problem of the two-dimensional theory of elasticity for a thickwalled ring with the uneven pressures, acting on its borders, was solved. The pressure on the inner and outer boundaries is represented by Fourier series. The authors represent the two complex functions which solve boundary problem in the form of Laurent series. The logarithmic terms in these series are absent because the boundary problem has the self-balancing loads on each boundary of ring. The coefficients in the Laurent series are calculated by the boundary conditions. Firstly, the equations were obtained in the general form. But the hypothesis about even distributions of pressures at borders of ring was used for constructing an example. It leads to the fact that all coefficients of analytic functions represented in Laurent series have to be only real. As a solving example, the representation of pressures in equivalent hypotrochoids was used. The application of the computer algebra system Mathematica greatly simplifies the calculation of the distribution of stresses and displacements in ring. It does not require manual formal separation of real and imaginary parts in terms of Kolosov-Muskhelishvili to display the distribution of the physical parameters. It separates them only for calculated numbers with the help of built-in functions.

  15. The Camino intracranial pressure sensor: is it optimal technology? An internal audit with a review of current intracranial pressure monitoring technologies.

    Piper, I; Barnes, A; Smith, D; Dunn, L


    To audit the reliability of the Camino intracranial pressure (ICP) sensor (Camino Laboratories, San Diego, CA) in our clinical practice as part of a continuing quality assurance program, and to assess its relative usefulness as compared with currently available ICP monitoring technologies that we reviewed. Prospective audit of ICP device reliability and function in 50 patients with head injuries. Zero drift was recorded immediately after the ICP device was removed from the patient. Dynamic frequency response bench testing of each functioning catheter from 0 to 30 Hz and static calibration testing from 0 to 100 mmHg during environmental temperature variation from 22 to 40 degrees C were carried out. Zero drift (range, -13 to 22 mmHg; median, -1 mmHg) was recorded immediately after the devices were removed from patients. Seventeen (50%) of the devices tested for zero drift had absolute drifts of at least 3 mmHg. There was no correlation between recorded zero drift and duration of monitoring (r = 0.154, P = 0.207). Five sensors (10% of those tested) failed during patient monitoring and were replaced. Static and dynamic calibration tests of the functioning sensors were within the manufacturer's specifications. However, the sensitivity of the devices to environmental temperature remains a problem. The Camino ICP sensor remains one of the most popular ICP monitoring devices for use in patients with traumatic brain injuries. However, our recent in-house assessment demonstrated the robustness of the device to be less than adequate during routine practice. In this study, more than 50% exhibited zero drift greater than 3 mmHg, which is unacceptable in a catheter tip ICP monitoring device in which zero drift and calibration cannot be checked in vivo. A review of the literature revealed that other available ICP monitoring devices may prove to be more reliable and thus more appropriate for routine clinical measurement of ICP.

  16. Doreen Norton OBE, MSc, SRN, FRCN (1922-2007): Pioneer who revolutionised pressure sore management and geriatric nursing to international acclaim.

    Denham, Michael J


    Doreen Norton was a delightful, widely respected nurse who devoted her life to improving the care of elderly people. She researched the neglected problem of pressure sores, revolutionised their nursing care, and thus achieved international fame. Her Pressure Sore Scale was established as a management tool and is still used today. She was a key member of the design team that produced the 'King's Fund Bed', researched equipment required on geriatric wards, assessed all geriatric long stay units in Scotland and established research as a valuable nursing tool within her profession and health authorities. She lectured extensively and her publications attracted worldwide acclamation. After her retirement, she was subsequently appointed to the world's first Chair of Gerontological Nursing in Cleveland, Ohio.

  17. Ventilación con liberación de presión en la vía aérea, en neonatos con insuficiencia respiratoria aguda Airway pressure release ventilation in newborns

    Emmanuel Jiménez-Castro


    Full Text Available La ventilación con liberación de presión en la vía aérea (APRVes una modalidad ventilatoria que utiliza presión positiva controlada en la vía aérea, con el fin de maximizar el reclutamiento alveolar, con tiempos inspiratorios prolongados, permitiendo la respiración espontánea durante ambas fases del ciclo respiratorio. Los autores describen su experiencia en una serie de 12 casos con pacientes neonatales con insuficiencia respiratoria aguda, que fueron tratados con la APRV ventilación con liberación de presión en la vía aérea, cuando la oxigenación no mejoró con la ventilación de control de presión. La edad media de los pacientes fue de 13± 16,5 días. La fracción inspirada de oxígeno disminuyó de 62,9±23,6 cm H2O para la ventilación de control de presión, a 44±14,0 cm H2O, para la APRV. El promedio de presión parcial de oxígenoaumentó de 54,6 ± 11,9mmHg a 92±32mmH; el promedio de presión parcial de CO2 disminuyó de 53,2±15,6 mmHg a 43,1±10mmHg, y la presión pico de la vía aérea se redujo de 16,8±5,9cm H2O a 16,6±5,3 cm de H2O, respectivamente. La ventilación con liberación de presión en la vía aérea, puede mejorar la oxigenación en pacientes pediátricos con insuficiencia respiratoria aguda, cuando la ventilación mecánica convencional falla.Airway pressure release ventilation is a mechanical ventilation method that uses a controlled positive airway pressure in order to maximize alveolar recruitment, with prolonged inspiratory times, therefore allowing spontaneous breathing during both phases of the respiratory cycle. The authors describe their experience in twelve cases of newborn patients with acute respiratory failure treated with airway pressure release ventilation when oxygenation did not improve with pressure control ventilation. The mean age of patients was 13 ± 16.5 days. The fractional concentration of oxygen (FiO2 decreased from 62.9 ± 23.6 cmH2O for pressure control ventilation to 44

  18. At the Fulcrum of Air Force Identity: Balancing the Internal and External Pressures of Image and Culture


    meaning, including internal 9 Kurt Lewin , Field Theory in Social Science (1951; repr., as Resolving Social...the years have also explored cases in which some identities are less central, more malleable, and less distinctive than commonly believed.8 Kurt ... Lewin laid 5 Mary Jo Hatch and Majken Schultz, ―The Dynamics of Organizational Identity,‖ Human Relations 55, no

  19. Blind Intubation through Self-pressurized, Disposable Supraglottic Airway Laryngeal Intubation Masks: An International, Multicenter, Prospective Cohort Study.

    Ruetzler, Kurt; Guzzella, Sandra Esther; Tscholl, David Werner; Restin, Tanja; Cribari, Marco; Turan, Alparslan; You, Jing; Sessler, Daniel I; Seifert, Burkhardt; Gaszynski, Tomasz; Ganter, Michael T; Spahn, Donat R


    Supraglottic airway devices commonly are used for securing the airway during general anesthesia. Occasionally, intubation with an endotracheal tube through a supraglottic airway is indicated. Reported success rates for blind intubation range from 15 to 97%. The authors thus investigated as their primary outcome the fraction of patients who could be intubated blindly with an Air-Qsp supraglottic airway device (Mercury Medical, USA). Second, the authors investigated the influence of muscle relaxation on air leakage pressure, predictors for failed blind intubation, and associated complications of using the supraglottic airway device. The authors enrolled 1,000 adults having elective surgery with endotracheal intubation. After routine induction of general anesthesia, a supraglottic airway device was inserted and patients were ventilated intermittently. Air leak pressure was measured before and after full muscle relaxation. Up to two blind intubation attempts were performed. The supraglottic airway provided adequate ventilation and oxygenation in 99% of cases. Blind intubation succeeded in 78% of all patients (95% CI, 75 to 81%). However, the success rate was inconsistent among the three centers (P intubation in nearly 80% of patients. It is thus a reasonable initial approach to airway control. Muscle relaxation can be used safely when unparalyzed leak pressure is adequate.

  20. Comparison of 4- versus 5-day Co-Synch + controlled internal drug release (CIDR) + timed artificial insemination protocols in dairy heifers.

    Palomares, Roberto A; Fishman, Heidi J; Jones, Arthur L; Ferrer, Maria S; Jenerette, Mathews; Vaughn, Aimee


    The objective of this study was to compare the pregnancy rate after timed artificial insemination (P/TAI) in dairy heifers treated with 4- versus 5-day Co-Synch + controlled internal drug release (CIDR) protocols. A total of 120 Holstein heifers were randomly assigned to one of two groups. The heifers received an intravaginal CIDR insert containing 1.38 g of progesterone for 4 days (Monday-Friday 4-day Co-Synch + CIDR; n = 60) or 5 days (5-day Co-Synch + CIDR; n = 60). At the time of CIDR removal, 25 mg of PGF2α was injected intramuscularly, and 72 hours after CIDR removal, the heifers received 100 μg of GnRH intramuscularly and were artificially inseminated. Artificial insemination was performed by an experienced technician, using commercial frozen-thawed semen from a single sire. Pregnancy diagnosis was performed by ultrasonography per rectum 32 days after TAI. Categorical data were analyzed using proc logistic and the chi-square test, whereas continuous variables were analyzed using the t-test of Statistical Analysis Systems. Heifers in the 4-day Co-Synch + CIDR group had an acceptable P/TAI32 (55.0%, 33 of 60), which was not different (P = 0.35) from that observed in the 5-day Co-Synch + CIDR group (63.3%, 38 of 60). Progesterone concentration at CIDR insertion or estradiol concentration at TAI did not influence the pregnancy outcomes. Interestingly, estradiol concentration at TAI was greater in the 4-day Co-Synch + CIDR group compared to the 5-day Co-Synch + CIDR group (P < 0.01). In conclusion, the Monday to Friday 4-day Co-Synch + CIDR protocol resulted in adequate P/TAI in dairy heifers, which was similar to that of the 5-day Co-Synch + CIDR protocol. This novel protocol might represent a promising hormonal treatment for TAI in dairy heifers, facilitating their reproductive management routine, while maintaining an adequate fertility.

  1. Ovarian follicular development and oocyte quality in anestrous ewes treated with melatonin, a controlled internal drug release (CIDR) device and follicle stimulating hormone.

    Luther, Justin S; Redmer, Dale A; Reynolds, Lawrence P; Choi, Jong Tae; Pant, Disha; Navanukraw, Chainarong; Arnold, Daniel R; Scheaffer, Abraham N; Borowicz, Pawel; Kirsch, James D; Weigl, Robert M; Kraft, Kim C; Grazul-Bilska, Anna T


    The objective of the current study was to determine the effects of hormonal treatments on ovarian follicular development and oocyte quality in anestrous ewes. Multiparous crossbred (RambouilletxTarghee) ewes were given melatonin implants (MEL) and/or controlled internal drug release (CIDR) devices in conjunction with follicle stimulating hormone (FSH) during anestrus (March-May). In Experiment 1, ewes (n=25) were assigned randomly to four groups (n=4-7/group) in a 2x2 factorial arrangement [+/-MEL and +/-CIDR], resulting in Control (no treatment), CIDR, MEL, and MEL/CIDR groups, respectively. Ewes received an implant containing 18 mg of melatonin (Melovine) on Day 42 and/or a CIDR from Days 7 to 2 (Day 0: oocyte collection). In Experiment 2, ewes (n=12) were assigned randomly to two groups (n=6/group; 1CIDR or 2CIDR) and received the same type of melatonin implant on Day 60. All ewes received a CIDR device from Days -22 to -17 and 2CIDR ewes received an additional CIDR device from Days -10 to -2. In both experiments, ewes were given FSH im twice daily (morning and evening) on Days -2 and -1 (Day -2: 5 units/injection; Day -1: 4 units/injection). On the morning of Day 0, ovaries were removed, follicles>or=1 mm were counted, and oocytes were collected. Thereafter oocytes were matured and fertilized in vitro. In Experiment 1, the number of visible follicles and the rates of oocyte recovery and in vitro maturation were similar (P>0.10) for Control, CIDR, MEL and MEL/CIDR (overall 29.7+/-2.9%, 89.9+/-7.1% and 95.0+/-2.0%, respectively). The rates of in vitro fertilization (IVF) were lower (P0.10) for 1CIDR and 2CIDR groups (overall 27.3+/-3.2%, 92.1+/-2.7% and 90.2+/-1.9%, respectively). However, the rates of IVF were lower (P<0.01) for 2CIDR than 1CIDR group (30.2% versus 58.0%, respectively). In summary, when treatment with P4 commenced only 2 d before oocyte collection, rates of IVF were reduced in both experiments. Therefore, progestin treatment protocols used in

  2. Results of the 2008-2009 International Pressure Ulcer Prevalence Survey and a 3-year, acute care, unit-specific analysis.

    VanGilder, Catherine; Amlung, Stephanie; Harrison, Patrick; Meyer, Stephanie


    The National Quality Forum has identified a pressure ulcer as a hospital-acquired condition (HAC) that is high-cost and high-volume and may be preventable with implementation of evidence-based guidelines. The Center for Medicare and Medicaid Services no longer reimburses acute care facilities for the ancillary cost of facility-acquired (FA) ulcers. Benchmarking patient safety indicators, such as FA, may help facilities reduce pressure ulcer rates. The purpose of this observational, cross-sectional cohort study was to report the International Pressure Ulcer Prevalence Survey (IPUP) in the United States in 2008 and 2009. In addition, previously collected data (2006/2007) were used to evaluate and report general and unit-specific prevalence rates in acute care facilities. The overall prevalence and FA pressure ulcer rates were 13.5% and 6% (2008, N = 90,398) and 12.3 and 5% (2009, N = 92,408), respectively. In 2008 and 2009, overall prevalence rates were highest in long-term acute care (22%). FA rates were highest in adult intensive care units (ICUs) and ranged from 9.2% (general cardiac care unit [CCU]) to 12.1% (medical ICU) in 2008 and from 8.8% (general CCU) to 10.3% (surgical ICU) in 2009. In 2009, 3.3% of ICU patients developed severe FA ulcers (Stage III, Stage IV, eschar/unable to stage, or deep tissue injury). In 2009, approximately 10% (n = 1,631) of all ulcers were described as device-related. The most common anatomic locations for device-related ulcers were the ear (20%) and sacral/coccyx region (17%). Both the overall and FA pressure ulcer prevalence rates were lower in 2008 and 2009 than in 2006 and 2007. Results indicate that, although overall prevalence trends are encouraging, there is a stark contrast from the desired state, especially in adult ICUs.

  3. 底板巷水力冲孔卸压增透技术的研究与应用%Study and Application on Pressure Releasing and Permeability Improved Technology with Hydraulic Flushing in Floor Gateway

    徐东方; 黄渊跃; 罗治顺; 杨献东


    In order to investigate the effect of the pressure releasing and permeability improved technology with hydraulic flushing in floor gateway to improve the seam permeability and to improve the gas drainage rate, a trial was conducted on the pressure releasing and permeability improved technology with hydraulic flushing in No. 1259(3) floor gateway of Puxijing.The results showed that the radius of the pressure releasing and permeability improvement with the hydraulic flushing borehole could reach 4~5 m and would be 1.6~2.0 times higher than the influence radius of the gas drainage with a conventional borehole. Within half month after the hydraulic flushing measures conducted, the average gas drainage concentration of the borehole was 2.77 times higher than the conventional borehole,the average gas flow value was 3.43 times higher than the conventional borehole,the effect of the pressure releasing and permeability improvement was relatively remarkable , the seam permeability was improved and the outburst danger was reduced.%为了考察底板巷水力冲孔卸压增透技术对增加煤层透气性,提高瓦斯抽采效果,在浦溪井1259(3)底板巷实施水力冲孔卸压增透技术试验.结果表明:水力冲孔卸压增透半径达到4~5m,为普通钻孔抽采影响半径的1.6~2.0倍;采取水力冲孔措施的半个月内,钻孔的平均瓦斯抽采浓度是普通钻孔的2.77倍,平均瓦斯流量是普通钻孔的3.43倍,卸压增透效果比较明显,提高了煤层透气性,降低了突出危险性.

  4. Gas depletion in Local Group dwarfs on ~250 kpc scales: Ram pressure stripping assisted by internal heating at early times

    Nichols, Matthew


    A recent survey of the Galaxy and M31 reveals that more than 90% of dwarf galaxies within 270 kpc of their host galaxy are deficient in HI gas. At such an extreme radius, the coronal halo gas is an order of magnitude too low to remove HI gas through ram-pressure stripping for any reasonable orbit distribution. However, all dwarfs are known to have an ancient stellar population (\\geq 10 Gyr) from early epochs of vigorous star formation which, through heating of HI, could allow the hot halo to remove this gas. Our model looks at the evolution of these dwarf galaxies analytically as the host-galaxy dark matter halo and coronal halo gas builds up over cosmic time. The dwarf galaxies - treated as spherically symmetric, smooth distributions of dark matter and gas - experience early star formation, which sufficiently heats the gas allowing it to be removed easily through tidal stripping by the host galaxy, or ram-pressure stripping by a tenuous hot halo (n_H = 3x10^{-4} cm^{-3} at 50 kpc). This model of evolution is...

  5. The effect of a trunk release maneuver on Peak Pressure Index, trunk displacement and perceived discomfort in older adults seated in a high Fowler’s position: a randomized controlled trial

    Best Krista L


    Full Text Available Abstract Background Pressure ulcers pose significant negative individual consequences and financial burden on the healthcare system. Prolonged sitting in High Fowler’s position (HF is common clinical practice for older adults who spend extended periods of time in bed. While HF aids in digestion and respiration, being placed in a HF may increase perceived discomfort and risk of pressure ulcers due to increased pressure magnitude at the sacral and gluteal regions. It is likely that shearing forces could also contribute to risk of pressure ulcers in HF. The purpose of this study was to evaluate the effect of a low-tech and time-efficient Trunk Release Manuever (TRM on sacral and gluteal pressure, trunk displacement and perceived discomfort in ambulatory older adults. Method A randomized controlled trial was used. We recruited community-living adults who were 60 years of age and older using posters, newspaper advertisements and word-of-mouth. Participants were randomly allocated to either the intervention or control group. The intervention group (n = 59 received the TRM, while the control group (n = 58 maintained the standard HF position. Results The TRM group had significantly lower mean (SD PPI values post-intervention compared to the control group, 59.6 (30.7 mmHg and 79.9 (36.5 mmHg respectively (p = 0.002. There was also a significant difference in trunk displacement between the TRM and control groups, +3.2 mm and −5.8 mm respectively (p = 0.005. There were no significant differences in perceived discomfort between the groups. Conclusion The TRM was effective for reducing pressure in the sacral and gluteal regions and for releasing the trunk at the point of contact between the skin and the support surface, but did not have an effect on perceived discomfort. The TRM is a simple method of repositioning which may have important clinical application for the prevention of pressure ulcers that may occur as a result of HF.

  6. "Deflategate": Time, Temperature, and Moisture Effects on Football Pressure

    Blumenthal, Jack; Beljak, Lauren; Macatangay, Dahlia-Marie; Helmuth-Malone, Lilly; McWilliams, Catharina; Raptis, Sofia


    In a recent paper in TPT, DiLisi and Rarick used the National Football League "Deflategate" controversy to introduce to physics students the physics of a bouncing ball. In this paper, we measure and analyze the environmental effects of time, ambient temperature, and moisture on the internal pressure of an NFL football. We focus on the rate of pressure recovery that occurs when a cold football (either wet or dry) is returned to the warm locker room environment where the pressure was initially measured. Both studies stem from the so-called NFL "Deflategate" controversy in which footballs that initially met a minimum internal pressure requirement were rechecked at halftime of the AFC Championship game, and in some cases were reported to have fallen below the minimum pressure requirement. The question is whether the pressure changes were due to environmental exposure or rather to some air being released from the balls, or both.

  7. Experimental investigation of certain internal condensing and boiling flows: Their sensitivity to pressure fluctuations and heat transfer enhancements

    Kivisalu, Michael Toomas

    Space-based (satellite, scientific probe, space station, etc.) and millimeter -- to -- micro-scale (such as are used in high power electronics cooling, weapons cooling in aircraft, etc.) condensers and boilers are shear/pressure driven. They are of increasing interest to system engineers for thermal management because flow boilers and flow condensers offer both high fluid flow-rate-specific heat transfer capacity and very low thermal resistance between the fluid and the heat exchange surface, so large amounts of heat may be removed using reasonably-sized devices without the need for excessive temperature differences. However, flow stability issues and degredation of performance of shear/pressure driven condensers and boilers due to non-desireable flow morphology over large portions of their lengths have mostly prevented their use in these applications. This research is part of an ongoing investigation seeking to close the gap between science and engineering by analyzing two key innovations which could help address these problems. First, it is recommended that the condenser and boiler be operated in an innovative flow configuration which provides a non-participating core vapor stream to stabilize the annular flow regime throughout the device length, accomplished in an energy-efficient manner by means of ducted vapor re-circulation. This is demonstrated experimentally.. Second, suitable pulsations applied to the vapor entering the condenser or boiler (from the re-circulating vapor stream) greatly reduce the thermal resistance of the already effective annular flow regime. For experiments reported here, application of pulsations increased time-averaged heat-flux up to 900 % at a location within the flow condenser and up to 200 % at a location within the flow boiler, measured at the heat-exchange surface. Traditional fully condensing flows, reported here for comparison purposes, show similar heat-flux enhancements due to imposed pulsations over a range of frequencies

  8. Administration of a GnRH analog on day 9 of a 14-day controlled internal drug release insert with timed artificial insemination in lactating beef cows.

    Giles, R L; Ahola, J K; Whittier, J C; French, J T; Repenning, P E; Kruse, S G; Seidel, G E; Peel, R K


    Many estrus synchronization protocols aim to induce a new follicular wave to improve response and enhance pregnancy rate. Our objectives were to determine the effectiveness of GnRH analog administered d 0 and 9 during an extended controlled internal drug release (CIDR) protocol to produce 2 follicular waves, induce cyclicity in anestrus cows, and evaluate the efficacy of a single 50-mg dose of PGF2α to initiate luteal regression on CIDR removal. Lactating beef cows (n = 779) at 3 locations (n = 247, location 1; n = 395, location 2; n = 137, location 3) were randomly assigned to 1 of 3 treatments. Cows in the 14-d 50 PG treatment received a CIDR (1.38 g progesterone) with 100 μg GnRH analog intramuscularly (i.m.) on d 0, 100 μg GnRH analog i.m. on d 9, and CIDR removal concurrent with 50 mg PGF2α i.m. on d 14. Cows in the 14-d 6-h PG treatment were assigned the same protocol as the 14-d 50 PG treatment except that 25 mg PGF2α i.m. was given on d 14 plus 25 mg PGF2α i.m. 6 ± 1 h later. Cows in the control treatment, 5-d CO-Synch + CIDR (5-d CO-Synch), received a CIDR concurrent with 100 μg GnRH analog i.m. on d 9, CIDR removal concurrent with 25 mg PGF2α i.m. on d 14, and 25 mg PGF2α i.m. 6 ± 1 h after first F2α injection. Cows in all treatments received 100 μg GnRH analog i.m. and timed AI (TAI) 72 ± 3 h after CIDR removal. Pregnancy status to TAI was determined by ultrasonography 37 to 40 d after TAI. Averaged over all locations, pregnancy rates to TAI for 14-d 50 PG, 14-d 6-h PG, and 5-d CO-Synch treatments were 58.2%, 46.8%, and 41.9%, respectively. Pregnancy rates to TAI were greater (P 1 ng/mL at either (or both) bleeding date were considered cyclic. Averaged over the 2 locations, there was a tendency (P = 0.06) for a greater number of cyclic animals to become pregnant to TAI in the 14-d 50 PG treatment (64.4%) than 5-d CO-Synch treatment (50.2%). The 14-d CIDR with GnRH analog on d 0 and 9 and a single 50-mg dose of PG i.m. at CIDR removal was a

  9. 右颈内静脉加压对颈内静脉穿刺置管术的影响%Effect of Right Internal Jugular Vein Pressure on Internal Jugular Vein Catheterization

    高恺; 张月秋; 高言国


    目的:探讨右颈内静脉加压对颈内静脉穿刺置管术的影响。方法:选取需进行右颈内静脉穿刺置管的低血容量性或脓毒性休克患者79例作为研究对象,随机分为对照组(C组)40例和颈内静脉加压组(P组)39例。所有患者均去枕平卧、Trendelenburg体位和头左侧偏转15°~30°,C组进行常规右颈内静脉穿刺置管,P组在C组基础上于患者右侧锁骨上窝靠近胸锁关节外侧凹陷处以食指中指二指并拢向内下方用力按压颈内静脉,以颈内静脉压瘪为宜。记录两组患者三次穿刺置管成功率、回血通畅率、穿刺失败率及血肿发生率。结果:P组穿刺置管成功率、回血通畅率、穿刺失败率及血肿发生率均优于C组,比较差异均有统计学意义(P<0.05)。结论:颈内静脉压迫明显有助于颈内静脉穿刺置管术的成功,减少了并发症。%Objective:To discuss the effect of right internal jugular vein pressure on internal jugular vein catheterization.Method:From May 2013 to March 2016,79 cases of low blood volume or septic shock with right internal jugular vein catheterization were selected as the research objects,they were divided into 40 cases of the control group(group C) and 39 cases of the internal jugular venous pressure group(group P).All patients had to lie,Trendelenburg position and the left side of the head deflection 15°-30°,group C were treated with conventional right internal jugular vein catheterization,group P was treated with an index finger and a middle finger were put together to push jugular veins hard inward and downward on the ipsilateral supraclavicular fossa near lateral recess of joints of the sternoclavicular joint until the veins were squashed based on group C,internal jugular vein press to make flat was appropriate.Three times puncture catheter success rate,the rate of return to blood,puncture failure rate and incidence of hematoma of two groups were

  10. The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study

    Santana Hugo AP


    Full Text Available Abstract Background The absence of the I allele of the angiotensin converting enzyme (ACE gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO2- and blood pressure (BP responses to different exercise intensities in elderly women divided according to their ACE genotype. Methods Participants (n = 30; II/ID = 20 and DD = 10 underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT; and 20 min control session without exercise. Volunteers had their BP and NO2- measured before and after experimental sessions. Results Despite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO2- release was observed only for carriers of the I allele (p Conclusion Genotypes of the ACE gene may exert a role in post-exercise NO release and BP response.

  11. Study on Seam Deformation and Permeability Improved Effect of Pressure Released Mining in Protective Seam%保护层卸压开采煤层变形与增透效应研究

    涂敏; 袁亮; 缪协兴; 刘泽功; 徐乃忠; 付宝杰


    为了研究高瓦斯赋存煤层卸压增透效应,以达到提高低渗透性松软煤层瓦斯抽采率,降低工作面瓦斯突出危险性,采用RFPA2D-Gasflow软件分析下保护层卸压开采后上覆煤岩采动裂隙发育、应力分布特征及由此产生的卸压煤层增透效应.结果表明:卸压开采煤层的透气性系数增大200倍左右,增透效果显著.利用该研究结果在顾桥矿沿空留巷内布置斜向上长短穿层钻孔,代替传统的底板巷内布置向上穿层钻孔抽采本层采空区内和上覆卸压煤层内瓦斯,可使沿空留巷中回风流和上隅角瓦斯体积分数均控制在0.5%以下,平均瓦斯抽采率达50% ~ 70%,保证了工作面的安全回采.%In order to study the pressure released and permeability improved effect of the high gas content seam and to reach the targets to improve the gas drainage rate of the low permeability soft seam and to reduce the gas outburst danger of the coal mining face,the RFPA -Gasflow software was applied to analyze the mining crack development and the stress distribution features of the overburden coal and rock and thus created pressure released and permeability effect after the pressure released mining in the underneath protective seam.The results showed that the permeability coefficient of the pressure released mining seam could be increased about 200 times and the permeability improved effect was obvious.The study results were applied to the layout of the inclined upward long and short boreholes in the gateway retained along goaf in Guqiao Mine to replace the layout of the inclined upward borehole in the conventional floor gateway for the gas drainage in the mining goaf and the overburden pressure released seam.Thus the gas volume fractions of the air returning flow in the gateway retained and the gas in the upper corner both could be controlled below 0. 5%, the average gas drainage rate could be 50% ~ 70% and the safety mining of the coal mining face

  12. The multi-layered ring under parabolic distribution of radial stresses combined with uniform internal and external pressure

    Christos F. Markides


    Full Text Available A recently introduced solution for the stress- and displacement-fields, developed in a multi-layered circular ring, composed of a finite number of linearly elastic concentric layers, subjected to a parabolic distribution of ra-dial stresses, is here extended to encompass a more general loading scheme, closer to actual conditions. The loading scheme includes, besides the para¬-bolic radial stresses, a combination of uniform pressures acting along the outer- and inner- most boundaries of the layered ring. The analytic solution of the problem is achieved by adopting Savin’s pioneering approach for an infinite plate with a hole strengthened by rings. Taking advantage of the results provided by the ana¬lytic solution, a numerical model, simulating the configuration of a three-layered ring (quite commonly encountered in practic¬al applications is validated. The numerical model is then used for a parametric analysis enlightening some crucial aspects of the overall response of the ring.

  13. Heat transfer and pressure drop performance of smooth and internally finned tubes with oil and refrigerant 22 mixtures

    Schlager, L.M. (Indiana-Purdue Univ., Ft. Wayne, IN (US)); Pate, M.B. (Iowa State Univ., Ames, IA (US)); Bergles, A.E. (Rensselaer Polytechnic Inst., Troy, NY (US))


    The overall performance of a smooth tube and two augmented tubes is compared by using an enhancement performance ratio, defined as the ratio of heat transfer enhancement to pressure drop increase. The augmented tubes are compared to the smooth tube with pure R-22 and with mixtures of R-22 plus 150-or 300-SUS naphthenic mineral oil. Additionally, the performance of all three tubes with refrigerant-oil mixtures is compared to performance of the same tube with pure refrigerant. Various oil concentrations up to 5% by weight were tested and mass flux was varied from 92,000 to 294,000 lb/h{circle dot}ft{sup 2} (125 to 400 kg/m{sup 2}{circle dot}s). Nominal evaporation conditions were 37{degrees}F(3{degrees}C) with inlet and outlet qualities of 15% and 85%, respectively. The condensation conditions were 105{degrees}F (41{degrees}C) with inlet and outlet qualities of 85% and 15%, respectively. The enhancement performance ratio of the micro-fin tube is consistently higher than that of the low-fin tube with either pure refrigerant or refrigerant-oil mixtures. With pure refrigerant, the enhancement performance ratio of the augmented tubes is generally greater than unity, indicating improved performance relative to a smooth tube.

  14. International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

    Parmar, Priyakumari Ganesh; Taal, H. Rob; Timpson, Nicholas J.; Howe, Laura D.; Verwoert, Germaine; Aalto, Ville; Uitterlinden, Andre G.; Briollais, Laurent; Evans, Dave M.; Wright, Margie J.; Newnham, John P.; Whitfield, John B.; Lyytikäinen, Leo-Pekka; Rivadeneira, Fernando; Boomsma, Dorrett I.; Viikari, Jorma; Gillman, Matthew W.; St Pourcain, Beate; Hottenga, Jouke-Jan; Montgomery, Grant W.; Hofman, Albert; Kähönen, Mika; Martin, Nicholas G.; Tobin, Martin D.; Raitakari, Ollie; Vioque, Jesus; Jaddoe, Vincent W.V.; Jarvelin, Marjo-Riita; Beilin, Lawrence J.; Heinrich, Joachim; van Duijn, Cornelia M.; Pennell, Craig E.; Lawlor, Debbie A.; Palmer, Lyle J.


    Background Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4–7 years), puberty (8–12 years), and postpuberty (13–20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5′-C-phosphate-G-3′ methylation site) during prepuberty (P=2.86×10–8) and rs872256 during puberty (P=8.67×10–9). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P<5×10–3. Using a P value threshold of <5×10–3, we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms. Conclusions Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects. PMID:26969751

  15. 热熔压敏胶性能与药物释放速率的关系研究%Study on relationship of properties and drug release rate of hot melt pressure sensitive adhesive

    俞振伟; 梁漪; 梁文权


    Objective: To investigate the relationship of properties and drug release rate of hot melt pressure sensitive adhesive ( HMPSA) , and to provide a recommendation of preparing and selecting of HMPSA for transdermal use. Method; HMPSA with different properties were prepared using styrene-isoprene-styrene triblock copolymer as main material, and the tacks, adhesions and cohesions were determined. Drug-in-adhesive type patches were prepared using α-asarone as model drug, and the drug release rates were investigated on single chamber diffusion cells using 60% ethanol solution as release media. Result; The prepared HMPSAs had different tacks, adhesions and cohesions. The drug release rates of HMPSA patches were related to the cohesions. The release rate decreased when the cohesion increased. Conclusion; The HMPSA with appropriate cohesion should be selected when preparing patches to balance the drug release rate and patch property.%目的:研究热熔压敏胶的性能与药物释放速率的关系,为经皮给药制剂用热熔压敏胶的制备与选择提供参考.方法:以苯乙烯-异戊二烯-苯乙烯三嵌段共聚物为主体材料制备了多种不同性能的热熔压敏胶,测定其初黏力、黏合力与内聚力;以α-细辛醚为模型药物制备各热熔压敏胶的胶黏分散型贴剂,以60%乙醇溶液为释放介质,于单室扩散池中测定药物的释放.结果:制备得到的热熔压敏胶具有不同的初黏力、黏合力与内聚力;热熔压敏胶贴剂的释放速率与热熔压敏胶的内聚力相关,内聚力越大,药物的释放速率就越慢.结论:制备贴剂时需选择内聚力适宜的热熔压敏胶,以达到药物释放速率和贴剂内聚力的平衡.

  16. Smart Composite Overwrapped Pressure Vessel - Integrated Structural Health Monitoring System to Meet Space Exploration and International Space Station Mission Assurance Needs

    Saulsberry, Regor; Nichols, Charles; Waller, Jess


    Currently there are no integrated NDE methods for baselining and monitoring defect levels in fleet for Composite Overwrapped Pressure Vessels (COPVs) or related fracture critical composites, or for performing life-cycle maintenance inspections either in a traditional remove-and-inspect mode or in a more modern in situ inspection structural health monitoring (SHM) mode. Implicit in SHM and autonomous inspection is the existence of quantitative accept-reject criteria. To be effective, these criteria must correlate with levels of damage known to cause composite failure. Furthermore, implicit in SHM is the existence of effective remote sensing hardware and automated techniques and algorithms for interpretation of SHM data. SHM of facture critical composite structures, especially high pressure COPVs, is critical to the success of nearly every future NASA space exploration program as well as life extension of the International Space Station. It has been clearly stated that future NASA missions may not be successful without SHM [1]. Otherwise, crews will be busy addressing subsystem health issues and not focusing on the real NASA mission

  17. Changes in recruitment, growth, and stock size of northern shrimp (Pandalus borealis) at West Greenland: temperature and density-dependent effects at released predation pressure

    Wieland, Kai


    was carried out oil a spatially disaggregated basis in order to account for the latitudinal differences in bottom temperature and shrimp density. Changes in recruitment and, with a lag of 2 years, in stock biomass were most pronounced in the northern part of its distributional range, while bottom temperature...... threshold of the optimal range in the northern regions has extended the distributional area that is most favourable for northern shrimp. This, together with a decreasing rate of exploitation and a continuous low predation pressure, resulted in an increase of the stock to a level at which density...

  18. Low temperature-pressure batch experiments and field push-pull tests: Assessing potential effects of an unintended CO2 release from CCUS projects on groundwater chemistry

    Mickler, P. J.; Yang, C.; Lu, J.; Reedy, R. C.; Scanlon, B. R.


    Carbon Capture Utilization and Storage projects (CCUS), where CO2 is captured at point sources such as power stations and compressed into a supercritical liquid for underground storage, has been proposed to reduce atmospheric CO2 and mitigate global climate change. Problems may arise from CO2 releases along discreet pathways such as abandoned wells and faults, upwards and into near surface groundwater. Migrating CO2 may inversely impact fresh water resources by increasing mineral solubility and dissolution rates and mobilizing harmful trace elements including As and Pb. This study addresses the impacts on fresh water resources through a combination of laboratory batch experiments, where aquifer sediment are reacted in their corresponding groundwater in 100% CO2 environments, and field push-pull tests where groundwater is equilibrated with 100% CO2, reacted in-situ in the groundwater system, and pulled out for analyses. Batch experiments were performed on aquifer material from carbonate dominated, mixed carbonate/silicalstic, and siliclastic dominated systems. A mixed silicalstic/carbonate system was chosen for the field based push-pull test. Batch experiment results suggest carbonate dissolution increased the concentration of Ca, Mg, Sr, Ba, Mn, U and HCO3- in groundwater. In systems with significant carbonate content, dissolution continued until carbonate saturation was achieved at approximately 1000 hr. Silicate dissolution increased the conc. of Si, K Ni and Co, but at much lower rates than carbonate dissolution. The elements As, Mo, V, Zn, Se and Cd generally show similar behavior where concentrations initially increase but soon drop to levels at or below the background concentrations (~48 hours). A Push-Pull test on one aquifer system produced similar geochemical behavior but observed reaction rates are higher in batch experiments relative to push-pull tests. Release of CO2 from CCUS sites into overlying aquifer systems may adversely impact groundwater quality

  19. Creep crack growth analysis using C{sub t}-parameter for internal circumferential and external axial surface cracks in a pressurized cylinder

    Tun, Nwe Ni; Yang, Hee Seung; Yu, Jong Min; Yoon, Kee Bong [Dept. of Mechanical Engineering, Chung Ang University, Seoul (Korea, Republic of)


    Creep crack growth at elevated temperatures is a critical consideration in estimating the remaining life of high temperature structural components and in deciding their inspection interval. In this study, creep crack growth analyses for external radial-axial and internal radial-circumferential surface cracks in a pressurized cylinder were conducted by an analytical method. The effect of crack depth and crack length on the variations in Ct and remaining life predictions were investigated for surface cracks with various initial aspect ratios. It was observed that the remaining life of an internal radial-circumferential surface crack was approximately 53 times longer than that of an external radial-axial surface crack for the same crack size and loading conditions with 316 stainless steel material. It was also observed that the variations in remaining life, crack propagations, and the Ct values were considerably sensitive to the crack location and crack depth. Convergence of crack aspect ratio was not observed when the crack depth ratio was increased. Since the method is independent of material properties and location of the crack geometries, it can be extended to various material properties and various locations of the surface crack geometries.

  20. Headache attributed to intracranial pressure alterations: applicability of the International Classification of Headache Disorders ICHD-3 beta version versus ICHD-2.

    Curone, M; Peccarisi, C; Bussone, G


    The association between headache and changes in intracranial pressure is strong in clinical practice. Syndromes associated with abnormalities of cerebrospinal fluid (CSF) pressure include spontaneous intracranial hypotension (SIH) and idiopathic intracranial hypertension (IIH). In 2013, the Headache Classification Committee of the International Headache Society (IHS) published the third International Classification of Headache Disorders (ICHD-3 beta version). The aim of this study was to investigate applicability of the new ICHD-3 versus ICHD-2 criteria in a clinical sample of patients with intracranial pressure (ICP) alterations. Patients admitted at our Headache Center for headache evaluation in whom a diagnosis of ICP alterations was performed were reviewed. 71 consecutive patients were studied. 40 patients (Group A) were diagnosed as IIH, 22 (Group B) as SIH, 7 (Group C) and 2 (Group D), respectively, as symptomatic intracranial hypertension and symptomatic intracranial hypotension. Main headache features were: in Group A, daily or nearly-daily headache (100 %) with diffuse/non-pulsating pain (73 %), aggravated by coughing/straining (54 %) and migrainous-associated symptoms (43 %). In Group B, an orthostatic headache (100 %) with nausea (29 %), vomiting (24 %), hearing disturbance (33 %), neck pain (48 %), hypacusia (24 %), photophobia (22 %) was reported. In Group C, a diffuse non-pulsating headache was present in 95 % with vomiting (25 %), sixth nerve palsy (14 %) and tinnitus (29 %). In Group D, an orthostatic headache with neck stiffness was reported by 100 %. Regarding applicability of ICHD-2 criteria in Group A, 73 % of the patients fitted criterion A; 100 %, criterion B; 100 %, criterion C; and 75 %, criterion D; while applying ICHD-3 beta version criteria, 100 % fitted criterion A; 97.5 %, criterion B; 100 %, criterion C; and 100 %, criterion D. In Group B, application of ICHD-2 showed 91 % patients fitting criterion A; 100 %, criterion B; 100

  1. Microstructural characterization and model of hardening for the irradiated austenitic stainless steels of the internals of pressurized water reactors; Caracterisation microstructurale et modelisation du durcissement des aciers austenitiques irradies des structures internes des reacteurs a eau pressurisee

    Pokor, C


    The core internals of Pressurized Water Reactors (PWR) are composed of SA 304 stainless steel plates and CW 316 stainless steel bolts. These internals undergo a neutron flux at a temperature between 280 deg C and 380 deg C which modifies their mechanical properties. These modifications are due to the changes in the microstructure of these materials under irradiation which depend on flux, dose and irradiation temperature. We have studied, by Transmission Electron Microscopy, the microstructure of stainless steels SA 304, CW 316 and CW 316Ti irradiated in a mixed flux reactor (OSIRIS at 330 deg C between 0,8 dpa et 3,4 dpa) and in a fast breeder reactor at 330 deg C (BOR-60) up to doses of 40 dpa. Moreover, samples have been irradiated at 375 deg C in a fast breeder reactor (EBR-II) up to doses of 10 dpa. The microstructure of the irradiated stainless steels consists in faulted Frank dislocation loops in the [111] planes of austenitic, with a Burgers vector of [111]. It is possible to find some voids in the solution annealed samples irradiated at 375 deg C. The evolution of the dislocations loops and voids has been simulated with a 'cluster dynamic' model. The fit of the model parameters has allowed us to have a quantitative description of our experimental results. This description of the microstructure after irradiation was coupled together with a hardening model by Frank loops that has permitted us to make a quantitative description of the hardening of SA 304, CW 316 and CW 316Ti stainless steels after irradiation at a certain dose, flux and temperature. The irradiation doses studied grow up to 90 dpa, dose of the end of life of PWR internals. (author)

  2. Vascular Health Assessment of The Hypertensive Patients (VASOTENS) Registry: Study Protocol of an International, Web-Based Telemonitoring Registry for Ambulatory Blood Pressure and Arterial Stiffness

    Parati, Gianfranco; Avolio, Alberto; Rogoza, Anatoly N; Kotovskaya, Yulia V; Mulè, Giuseppe; Muiesan, Maria Lorenza; Orlova, Iana A; Grigoricheva, Elena A; Cardona Muñoz, Ernesto; Zelveian, Parounak H; Pereira, Telmo; Peixoto Maldonado, João Manuel


    Background Hypertension guidelines recommend ambulatory blood pressure (ABP), central aortic pressure (CAP), and pulse wave velocity (PWV) as parameters for estimating blood pressure (BP) control and vascular impairment. Recent advances in technology have enabled devices to combine non-invasive estimation of these parameters over the 24-hour ABP monitoring. However, currently there is limited evidence on the usefulness of such an approach for routine hypertension management. Objective We recently launched an investigator-initiated, international, multicenter, observational, prospective study, the Vascular health Assessment Of The Hypertensive patients (VASOTENS) Registry, aimed at (1) evaluating non-invasive 24-hour ABP and arterial stiffness estimates (through 24-hour pulse wave analysis, PWA) in hypertensive subjects undergoing ambulatory blood pressure monitoring (ABPM) for clinical reasons; (2) assessing the changes in estimates following treatment; (3) weighing the impact of 24-hour PWA on target organ damage and cardiovascular prognosis; (4) assessing the relationship between arterial stiffness, BP absolute mean level and variability, and prognosis; and (5) validating the use of a 24-hour PWA electronic health (e-health) solution for hypertension screening. Methods Approximately 2000 subjects, referred to 20 hypertension clinics for routine diagnostic evaluation and follow-up of hypertension of any severity or stage, will be recruited. Data collection will include ABPM, performed with a device allowing simultaneous non-invasive assessment of 24-hour CAP and arterial stiffness (BPLab), and clinical data (including cardiovascular outcomes). As recommended by current guidelines, each patient will be followed-up with visits occurring at regular intervals (ideally every 6 months, and not less than once a year depending on disease severity). A Web-based telemedicine platform (THOLOMEUS) will be used for data collection. The use of the telemedicine system will allow

  3. Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels.

    Vaca, Luis; Sampieri, Alicia


    In the present study we have explored the role of calmodulin (CaM) and inositol 1,4,5-trisphosphate receptor (IP(3)R) in the communication process activated after the release of calcium from the endoplasmic reticulum (ER) and the activation of calcium influx via endogenous TRP1 channels from Chinese hamster ovary cells. Experiments using combined rapid confocal calcium and electrophysiology measurements uncovered a consistent delay of around 900 ms between the first detectable calcium released from the ER and the activation of the calcium current. This delay was evident with two different methods used to release calcium from the ER: either the blockade of the microsomal calcium ATPase with thapsigargin or activation of bradykinin receptors linked to the IP(3) cascade. Direct application of IP(3) or a peptide from the NH(2)-terminal region of the IP(3)R activated store operated calcium, reducing the delay period. Introduction of CaM into the cell via the patch pipette increased the delay period from 900 +/- 100 ms to 10 +/- 2.1 s (n = 18). Furthermore, the use of selective CaM antagonists W7 and trifluoperazine maleate resulted in a substantial reduction of the delay period to 200 +/- 100 ms with 5 microm trifluoperazine maleate (n = 16) and 150 +/- 50 ms with 500 nm W7 (n = 22). CaM reduced also the current density activated by thapsigargin or brandykinin to about 60% from control. The CaM antagonists did not affect significantly the current density. The results presented here are consistent with an antagonistic effect of IP(3)R and CaM for the activation of store operated calcium after depletion of the ER. The functional competition between the activating effect of IP(3)R and the inhibiting effect of CaM may modulate the delay period between the release of calcium from the ER and the activation of calcium influx observed in different cells, as well as the amount of current activated after depletion of the ER.

  4. Measures to influence nitric oxide formation and alkali release in coal dust combustion under pressure; Massnahmen zur Beeinflussung der Stickoxidbildung und Alkalienfreisetzung bei der Kohlenstaubdruckverbrennung

    Thielen, W.; Niepel, H. [Steinmueller (L.u.C.) GmbH, Gummersbach (Germany)


    Messrs. Steinmueller are making the following contributions to the Dorsten experimental plant: Development of pressure burner and combustion chamber, fuel supply and flue gas analysis, especially the development of a high-temperature flue gas tapping unit at the end of the hot reaction zone. Burner development should always aim at complete converstion of the fuel and minimal pollutant emissions, as well as stable combustion over a wide range of operating conditons and maximum reliability in case of disturbances. Tools for development and experiment analysis are flow measurements in isothermal models, numerical flow and radiation excchange calculation programs, and reference data from the hot operation under pressure of the small-scale Dorsten pilot plant. The contribution presents the results of the burner experiments with a view to nitric oxide and alkali emissions; finally, the effects of different influencing parameters on combustion control and on the still unresolved fields of investigation are indicated. [Deutsch] Die Druckkohlenstaubfeuerung erschliesst fuer den Brennstoff Kohle durch Nutzung des Gas- und Dampfturbinenprozesses Kraftwerkswirkungsgrade im Bereich von 50 % und mehr. Dabei soll das unter Druck verbrannte Rauchgas nach Abscheidung aller schaedlichen Bestandteile, insbesondere der Asche, die in diesem Temperaturbereich durchweg schmelzfluessig vorliegt, direkt auf die Gasturbine geleitet werden. Mit Foerderung des Bundes (seinerzeit BMFT) wurde unter Beteiligung der GHS Essen, mehrerer Industriepartner und Energieversorger am Zechenstandort Dorsten eine Kleinpilotanlage mit einer thermischen Leistung von ca 1 MW errichtet und seither betrieben. Der Forschungsschwerpunkt der L. und C. Steinmueller GmbH richtete sich darin auf die Thematik Kohleumwandlung. Die Aktivitaeten umfssten die Bereiche Druckbrenner- und Brennkammerentwicklung, die Brennstoffversorgung und die Rauchgasanalytik, hier insbesondere die Entwicklung einer Hochtemperatur

  5. O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies.

    Huang, Zhangjian; Kaur, Jatinder; Bhardwaj, Atul; Alsaleh, Nasser; Reisz, Julie A; DuMond, Jenna F; King, S Bruce; Seubert, John M; Zhang, Yihua; Knaus, Edward E


    New types of nonexplosive O(2)-sulfonylethyl protected (-CH(2)CH(2)SO(2)R; R = OMe, NHOMe, NHOBn, Me) derivatives of isopropylamine diazen-1-ium-1,2-diolate (IPA/NO) (2-5) were developed that are designed to act as novel HNO donors. These compounds, with suitable half-lives (6.6-17.1 h) at pH 7.4, undergo a base-induced β-elimination reaction that releases a methyl vinyl sulfone product and the parent IPA/NO anion which subsequently preferentially releases HNO (46-61% range). Importantly, the O(2)-methylsulfonylethyl compound 5 exhibited a significant in vitro inotropic effect up to 283% of the baseline value and increased the rates of contraction and relaxation but did not induce a chronotropic effect. Furthermore, compound 5 (22.5 mg/kg po dose) provided a significant reduction in blood pressure up to 6 h after drug administration. All these data suggest that O(2)-sulfonylethyl protected derivatives of IPA/NO, which are efficient HNO donors, could have potential applications to treat cardiovascular disease(s) such as congestive heart failure.

  6. Effects of the Trendelenburg Position and Positive End-Expiratory Pressure on the Internal Jugular Vein Cross-Sectional Area in Children With Simple Congenital Heart Defects.

    Kim, Hee Yeong; Choi, Jae Moon; Lee, Yong-Hun; Lee, Sukyung; Yoo, Hwanhee; Gwak, Mijeung


    Catheterization of the internal jugular vein (IJV) remains difficult in pediatric populations. Increasing the cross-sectional area (CSA) of the IJV facilitates cannulation and decreases complications. We aimed to evaluate the Trendelenburg position and the levels of positive end-expiratory pressure (PEEP) at which the maximum increase of CSA of the IJV occurred in children undergoing cardiac surgery.In this prospective study, the CSA of the right IJV was assessed using ultrasound in 47 anesthetized pediatric patients with simple congenital heart defects. The baseline CSA was obtained in response to a supine position with no PEEP and compared with 5 different randomly ordered maneuvers, that is, a PEEP of 5 and 10 cm H2O in a supine position and of 0, 5, and 10 cm H2O in a 10° Trendelenburg position. Hemodynamic variables, including blood pressure and heart rate, maximum and minimum diameters, and CSA, were measured.All maneuvers increased the CSA of the right IJV with respect to the control condition. In the supine position, the CSA was increased by 9.4% with a PEEP of 5 and by 19.5% with a PEEP of 10 cm H2O. The Trendelenburg tilt alone increased the CSA by 19.0%, and combining the 10° Trendelenburg with a 10 cm H2O PEEP resulted in the largest IJV CSA increase (33.3%) compared with the supine position with no PEEP. Meanwhile, vital signs remained relatively steady during the experiment.The application of the Trendelenburg position and a 10 cm H2O PEEP thus significantly increases the CSA of the right IJV, perhaps improving the chances of successful cannulation in pediatric patients with simple congenital heart defects.

  7. Compression-tracking photoacoustic perfusion and microvascular pressure measurements

    Choi, Min; Zemp, Roger


    We propose a method to measure blood pressure of small vessels non-invasively and in-vivo: by combining PA imaging with compression US. Using this method, we have shown pressure-lumen area tracking, as well as estimation of the internal vessel pressure, located 2 mm deep in tissue. Additionally, reperfusion can be tracked by measuring the total PA signal within a region of interest (ROI) after compression has been released. The ROI is updated using cross-correlation based displacement tracking1. The change in subcutaneous perfusion rates can be seen when the temperature of the hand of a human subject drops below the normal.

  8. NOAA/NGDC candidate models for the 11th generation International Geomagnetic Reference Field and the concurrent release of the 6th generation POMME magnetic model


    The International Geomagnetic Reference Field (IGRF) is updated every five years based on candidate model submissions by research institutions worldwide. In the call for the 11th generation of IGRF, candidates were requested for the definitive main field in 2005, the predicted main field in 2010, and the predicted secular variation from 2010 to 2015. The NOAA/NGDC candidate models for IGRF-11 were produced from parent models parameterized in the same way as the 6th generation of our Pomme mag...

  9. Conséquences de l'effet de fond sur l'instabilité des conduites soumises à une pression interne Consequences of the End Effect on the Instability of Pipes Subjected to Internal Pressure

    Bournazel C.


    Full Text Available Cet article a pour objet d'éclairer, par quelques exemples concrets et simples, les problèmes inhérents à la mécanique statique des tubes élancés soumis à une pression interne. En effet, la production pétrolière en mer, par grande profondeur d'eau, amène de plus en plus souvent à des solutions originales d'assemblage des conduites ou à envisager l'emploi de nouveaux matériaux anisotropes. Cela peut conduire à des instabilités mécaniques (flambement des tubes, ou bien entraîner des surcontraintes de traction ou de flexion importantes qu'il est nécessaire d'analyser avec précaution. Cette analyse est au demeurant indispensable pour déterminer avec plus de précision les spécifications et les coefficients de sécurité applicables aux nouveaux produits tubulaires envisageables pour ces objectifs. he aim of this article is to give a few concrete and simple examples so as to illustrate the problems inherent in the static mechanics of slender tube subjected to internal pressure. Offshore oil production at great water depths more and more frequently involves original solutions for the assembly of pipes or the possible use of new anisotropic materials This may result in mechanical instabilities (buckling of the tubes or even cause traction overstresses or great bending forces which must be very carefully analyzed. This analysis, moreover is indispensable for more accurately determining the safety specifications and coefficients which are applicable to new tubular products being considered for such objectives.

  10. Prediction of fracture parameters of circumferential through-wall cracks in the interface between an elbow and a pipe under internal pressure

    Jang, Youn Young; Huh, Nam Su [Dept. of Mechanical System Design Engineering, Seoul National Univ. of Science and Technology, Seoul (Korea, Republic of); Jeong, Jae Uk [Doosan Heavy Industries and Construction, Changwon (Korea, Republic of)


    This paper provides plastic influence functions of GE/EPRI method for calculating J and Crack opening displacement (COD) of pipes with a circumferential Through-wall crack (TWC) in the interface between an elbow and a straight pipe by using 3-dimensional (3-D) elastic-plastic finite element analyses for Ramberg-Osgood (R-O) materials, in which internal pressure was considered as a loading condition. The proposed plastic influence functions are tabulated as a function of the pipe geometries, crack length and strain hardening exponent. In order to provide sufficient confidence for the proposed plastic influence functions, the estimation scheme using the proposed plastic influence functions for J and COD of cracked elbows was validated against FE results using R-O parameters for the SA312 TP316 stainless steel. Moreover, the predicted J and COD for elbows with a TWC in the interface between an elbow and a pipe by the proposed scheme were compared with those for cracked straight pipes to investigate the effect of the elbow geometries on crack behavior of elbows. One important point is that crack behaviors in the interface between an elbow and a straight pipe can be significantly different with those in straight pipes according to pipe thickness, crack length and bend radius of elbows. Thus, the proposed plastic influence functions can be useful to predict accurate J and COD for cracked elbows.

  11. Development and Progress of Ireland's Biobank Network: Ethical, Legal, and Social Implications (ELSI), Standardized Documentation, Sample and Data Release, and International Perspective

    Mee, Blanaid


    Biobank Ireland Trust (BIT) was established in 2004 to promote and develop an Irish biobank network to benefit patients, researchers, industry, and the economy. The network commenced in 2008 with two hospital biobanks and currently consists of biobanks in the four main cancer hospitals in Ireland. The St. James\\'s Hospital (SJH) Biobank coordinates the network. Procedures, based on ISBER and NCI guidelines, are standardized across the network. Policies and documents—Patient Consent Policy, Patient Information Sheet, Biobank Consent Form, Sample and Data Access Policy (SAP), and Sample Application Form have been agreed upon (after robust discussion) for use in each hospital. An optimum sequence for document preparation and submission for review is outlined. Once consensus is reached among the participating biobanks, the SJH biobank liaises with the Research and Ethics Committees, the Office of the Data Protection Commissioner, The National Cancer Registry (NCR), patient advocate groups, researchers, and other stakeholders. The NCR provides de-identified data from its database for researchers via unique biobank codes. ELSI issues discussed include the introduction of prospective consent across the network and the return of significant research results to patients. Only 4 of 363 patients opted to be re-contacted and re-consented on each occasion that their samples are included in a new project. It was decided, after multidisciplinary discussion, that results will not be returned to patients. The SAP is modeled on those of several international networks. Biobank Ireland is affiliated with international biobanking groups—Marble Arch International Working Group, ISBER, and ESBB. The Irish government continues to deliberate on how to fund and implement biobanking nationally. Meanwhile BIT uses every opportunity to promote awareness of the benefits of biobanking in events and in the media.

  12. Development and progress of Ireland's biobank network: Ethical, legal, and social implications (ELSI), standardized documentation, sample and data release, and international perspective.

    Mee, Blanaid; Gaffney, Eoin; Glynn, Sharon A; Donatello, Simona; Carroll, Paul; Connolly, Elizabeth; Garrigle, Sarah Mc; Boyle, Terry; Flannery, Delia; Sullivan, Francis J; McCormick, Paul; Griffin, Mairead; Muldoon, Cian; Fay, Joanna; O'Grady, Tony; Kay, Elaine; Eustace, Joe; Burke, Louise; Sheikh, Asim A; Finn, Stephen; Flavin, Richard; Giles, Francis J


    Biobank Ireland Trust (BIT) was established in 2004 to promote and develop an Irish biobank network to benefit patients, researchers, industry, and the economy. The network commenced in 2008 with two hospital biobanks and currently consists of biobanks in the four main cancer hospitals in Ireland. The St. James's Hospital (SJH) Biobank coordinates the network. Procedures, based on ISBER and NCI guidelines, are standardized across the network. Policies and documents-Patient Consent Policy, Patient Information Sheet, Biobank Consent Form, Sample and Data Access Policy (SAP), and Sample Application Form have been agreed upon (after robust discussion) for use in each hospital. An optimum sequence for document preparation and submission for review is outlined. Once consensus is reached among the participating biobanks, the SJH biobank liaises with the Research and Ethics Committees, the Office of the Data Protection Commissioner, The National Cancer Registry (NCR), patient advocate groups, researchers, and other stakeholders. The NCR provides de-identified data from its database for researchers via unique biobank codes. ELSI issues discussed include the introduction of prospective consent across the network and the return of significant research results to patients. Only 4 of 363 patients opted to be re-contacted and re-consented on each occasion that their samples are included in a new project. It was decided, after multidisciplinary discussion, that results will not be returned to patients. The SAP is modeled on those of several international networks. Biobank Ireland is affiliated with international biobanking groups-Marble Arch International Working Group, ISBER, and ESBB. The Irish government continues to deliberate on how to fund and implement biobanking nationally. Meanwhile BIT uses every opportunity to promote awareness of the benefits of biobanking in events and in the media.

  13. NOAA/NGDC candidate models for the 11th generation International Geomagnetic Reference Field and the concurrent release of the 6th generation Pomme magnetic model

    Maus, S.; Manoj, C.; Rauberg, J.; Michaelis, I.; Lühr, H.


    The International Geomagnetic Reference Field (IGRF) is updated every five years based on candidate model submissions by research institutions worldwide. In the call for the 11th generation of IGRF, candidates were requested for the definitive main field in 2005, the predicted main field in 2010, and the predicted secular variation from 2010 to 2015. The NOAA/NGDC candidate models for IGRF-11 were produced from parent models parameterized in the same way as the 6th generation of our Pomme magnetic model. All models were based on CHAMP satellite measurements, while Ørsted satellite measurements were used for model validation. The internal field in Pomme-6 is described by a 2nd degree Taylor time series of spherical harmonic expansion coefficients of a scalar magnetic potential. Magnetic fields of ionospheric origin are avoided by careful data selection. Instead of co-estimating magnetospheric fields, we subtract a magnetospheric field model estimated previously from a more extensive data set covering all local times. From comparison with Örsted measurements and general considerations of magnetic field predictability, we attribute a root mean square (RMS) uncertainty of 1.3 nT to our candidate model for the main field in 2005, 2.5 nT to the predicted main field in 2010 and 26 nT/a to the predicted secular variation from 2010 to 2015.

  14. Research on Prompt Release of the International Tribunal for the Law of the Sea%国际海洋法法庭迅速释放问题研究

    任虎; 姚妍韡


    Since the establishment of the International Tribunal for the Law of the Sea (ITLOS),there have been nine cases related to prompt release process,six of which were sentenced that the defendant coastal states should prompt release the detained vessels and crews,so as to effectively solve the disputes between coastal states and flag states.Because the rules on prompt release under the United Nations Convention on the Law of the Sea are vague,and the tribunal is inconsistent on the judgement standard of the rationality of bond security and the substantive examination problem,it fails to form customary law in the practice field of prompt release.It can be determined that the judicial practice of the tribunal has played a positive role to perfect the related legal system of coastal countries.In order to maintain our marine rights,China should timely modify and improve the assistance system and solve the problem of bond security of prompt release,when Chinese fishermen are de-tained by foreign law enforcement.%国际海洋法法庭自成立以来共审理了9个迅速释放案件,其中6个案件判决被告沿海国迅速释放被扣押船只和船员,从而有效地解决了沿海国和船旗国之间的争议。因联合国海洋法公约迅速释放相关规定的模糊性,以及国际海洋法法庭在保证金合理性判断标准和实质性审查问题上所采取的非一致性立场,在迅速释放问题上尚未形成习惯法。应该肯定的是,国际海洋法法庭的司法实践对沿海国相关法律制度的完善起到积极作用。本文认为,为维护我国海洋权利不受非法侵犯,应及时修改和完善我国渔民被外国执法扣押时的国家援助制度,以及解决迅速释放时的保证金制度问题。

  15. “三软”煤层水力冲孔卸压增透技术研究%Study on pressure releasing and permeability improving technology with hydraulic flushing in “three soft”coal seam

    何志龙; 孙谦; 宋大钊; 高勤琼


    针对糯东煤矿“三软”高瓦斯低透气性煤层易流变、难抽采的问题,提出了底板巷道穿层水力冲孔卸压增透技术,并在糯东煤矿11702掘进工作面进行了现场试验。结果表明:冲孔后比冲孔前抽采瓦斯浓度上升3.4倍,瓦斯抽采流量增加4.4倍,炮掘工作面回风流中的瓦斯(体积分数)由冲孔前0.8%的超限预警状态变成冲孔后的0.4%的安全范围,水力冲孔技术应用效果显著,在糯东煤矿取得了良好的卸压增透效果。%To solve the problem of easy rheology and hard drainage in"three soft"coal seam with high gas concentration and low permeability in Nuodong coal mine,the pressure releasing and permeability improving technology with hydraulic flushing in floor gateway was proposed,and corresponding field test at the No.11702 heading face of Nuodong coal mine was carried out.The re-sults show that the drained gas concentration after hydraulic flushing is 3.4 times as that without hydraulic flushing and the gas flow rate is increased by 4.4 times;and the gas concentration at the blasting working face changes from 0.8% (overrun warning state,before hydraulic flushing)to 0.4% (safety state,after hydraulic flushing).The application of hydraulic flushing technolo-gy is more effective and remarkable in releasing pressure and improving permeability in Nuodong coal mine.

  16. Determination of internal pressure and the backfill gas composition of nuclear fuel rods; Determinacion de la presion interna y la composicion del gas de llenado de barras de combustible nuclear

    Garcia C, M.A.; Cota S, G.; Merlo S, L.; Fernandez T, F. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)


    An important consideration in the nuclear fuel manufacturing is the measurement of the helium atmosphere pressure and its composition analysis inside the nuclear fuel rod. In this work it is presented a system used to measure the internal pressure and to determine the backfill gas composition of fuel rods. The system is composed of an expansion chamber provided of a seals system to assure that when rod is drilled, the gas stays contained inside the expansion chamber. The system is connected to a pressure measurement digital system: Baratron MKS 310-AHS-1000. Range 1000 mm Hg from which the pressure readings are taken when this is stabilized in all the system. After a gas sample is sent toward a Perkin Elmer gas chromatograph, model 8410 with thermal conductivity detector to get the corresponding chromatogram and doing the necessary calculations for obtaining the backfill gas composition of the rod in matter. (Author)

  17. Investigations on the effect of chlorine in lubricating oil and the presence of a diesel oxidation catalyst on PCDD/F releases from an internal combustion engine.

    Dyke, Patrick H; Sutton, Mike; Wood, David; Marshall, Jonathan


    This paper reports on an intensive study into releases of polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated furans (PCDF) and polychlorinated biphenyls (PCB) from a diesel engine and the analysis of PCDD/F and PCB in crankcase lubricating oil. Experimental conditions were set and carefully controlled in order to maximize the possible impact of, and our ability to measure the effect of, changes in the levels of chlorine in the lubricant. Emissions to air were measured using modified EPA methods following the principles of the European EN 1948 standards. A series of 40 experimental runs were completed using three reference lubricants formulated to have three levels of chlorine present as a residual component (at levels of 12, 131 and 259 mg kg(-1) or ppm). The engine was run with and without the diesel oxidation catalyst. All lubricants were realistic oils and the use of unrealistic additives or doping of components - particularly chlorine - in the fuel and lubricant was carefully avoided. Analysis of fuel and lubricant (before and after testing) samples required strenuous attention to achieve acceptable recoveries and showed non-detectable levels of PCB and PCDD/F at a detection limit of around 1.5 ng I-TEQ kg(-1) (ppt), indistinguishable from the laboratory blank. The testing demonstrated the need for extreme care to be taken in developing measurement methods that are sufficiently sensitive for measuring chlorine content of fluids and PCDD/F in oils, the latter being particularly challenging. Mean emissions of PCDD/F with the diesel oxidation catalyst in place were 23 pg I-TEQ l(-1) of fuel and with the diesel oxidation catalyst removed 97 pg I-TEQ l(-1) of fuel. The results of this testing showed that the emissions of PCDD/F were greatly reduced by the presence of a diesel oxidation catalyst in the exhaust, a finding that has not been explicitly tested in previous work. They also show that emissions from the engine were not controlled by the level of

  18. Tritium and helium retention and release from irradiated beryllium

    Anderl, R.A.; Longhurst, G.R.; Oates, M.A.; Pawelko, R.J. [Idaho National Engineering and Environmental Lab., Idaho Falls, ID (United States)


    This paper reports the results of an experimental effort to anneal irradiated beryllium specimens and characterize them for steam-chemical reactivity experiments. Fully-dense, consolidated powder metallurgy Be cylinders, irradiated in the EBR-II to a fast neutron (>0.1 MeV) fluence of {approx}6 x 10{sup 22} n/cm{sup 2}, were annealed at temperatures from 450degC to 1200degC. The releases of tritium and helium were measured during the heat-up phase and during the high-temperature anneals. These experiments revealed that, at 600degC and below, there was insignificant gas release. Tritium release at 700degC exhibited a delayed increase in the release rate, while the specimen was at 700degC. For anneal temperatures of 800degC and higher, tritium and helium release was concurrent and the release behavior was characterized by gas-burst peaks. Essentially all of the tritium and helium was released at temperatures of 1000degC and higher, whereas about 1/10 of the tritium was released during the anneals at 700degC and 800degC. Measurements were made to determine the bulk density, porosity and specific surface area for each specimen before and after annealing. These measurements indicated that annealing caused the irradiated Be to swell, by as much as 14% at 700degC and 56% at 1200degC. Kr gas adsorption measurements for samples annealed at 1000degC and 1200degC determined specific surface areas between 0.04 m{sup 2}/g and 0.1 m{sup 2}/g for these annealed specimens. The tritium and helium gas release measurements and the specific surface area measurements indicated that annealing of irradiated Be caused a porosity network to evolve and become surface-connected to relieve internal gas pressure. (author)

  19. Environmental and social pressure as drivers of corporate social responsibility in a globalizing world

    Haleem, Fazli; Farooq, Sami; Boer, Harry


    Studies of drivers of corporate social responsibility (CSR) practices that also explore the influence of company size and location are rare. This paper fills this gap by showing the extent to which environmental and social pressures affect the efforts companies put into implementing internal and ...... and external CSR practices and how size and location affect this relationship. The paper is based on data collected in 2013 using the sixth release of the International Manufacturing Strategy Survey....

  20. Internal jugular vein: Peripheral vein adrenocorticotropic hormone ratio in patients with adrenocorticotropic hormone-dependent Cushing′s syndrome: Ratio calculated from one adrenocorticotropic hormone sample each from right and left internal jugular vein during corticotrophin releasing hormone stimulation test

    Sachin Chittawar


    Full Text Available Background: Demonstration of central: Peripheral adrenocorticotropic hormone (ACTH gradient is important for diagnosis of Cushing′s disease. Aim: The aim was to assess the utility of internal jugular vein (IJV: Peripheral vein ACTH ratio for diagnosis of Cushing′s disease. Materials and Methods: Patients with ACTH-dependent Cushing′s syndrome (CS patients were the subjects for this study. One blood sample each was collected from right and left IJV following intravenous hCRH at 3 and 5 min, respectively. A simultaneous peripheral vein sample was also collected with each IJV sample for calculation of IJV: Peripheral vein ACTH ratio. IJV sample collection was done under ultrasound guidance. ACTH was assayed using electrochemiluminescence immunoassay (ECLIA. Results: Thirty-two patients participated in this study. The IJV: Peripheral vein ACTH ratio ranged from 1.07 to 6.99 ( n = 32. It was more than 1.6 in 23 patients. Cushing′s disease could be confirmed in 20 of the 23 cases with IJV: Peripheral vein ratio more than 1.6. Four patients with Cushing′s disease and 2 patients with ectopic ACTH syndrome had IJV: Peripheral vein ACTH ratio less than 1.6. Six cases with unknown ACTH source were excluded for calculation of sensitivity and specificity of the test. Conclusion: IJV: Peripheral vein ACTH ratio calculated from a single sample from each IJV obtained after hCRH had 83% sensitivity and 100% specificity for diagnosis of CD.

  1. Atmospheric pressure: Russian drug policy as a driver for violations of the UN Convention against Torture and the International Covenant on Economic, Social and Cultural Rights.

    Golichenko, Mikhail; Sarang, Anya


    Responding to problematic drug use in Russia, the government promotes a policy of "zero tolerance" for drug use and "social pressure" against people who use drugs (PWUD), rejecting effective drug treatment and harm reduction measures. In order to assess Russian drug policy against the UN Convention Against Torture and the International Covenant on Economic, Social, and Cultural Rights, we reviewed published data from government and non-governmental organizations, scientific publications, media reports, and interviews with PWUD. Drug-dependent people (DDP) are the most vulnerable group of PWUD. The state strictly controls all aspects of drug dependence. Against this background, the state promotes hatred towards PWUD via state-controlled media, corroding public perception of PWUD and of their entitlement to human rights. This vilification of PWUD is accompanied by their widespread ill-treatment in health care facilities, police detention, and prisons. In practice, zero tolerance for drug use translates to zero tolerance for PWUD. Through drug policy, the government deliberately amplifies harms associated with drug use by causing PWUD (especially DDP) additional pain and suffering. It exploits the particular vulnerability of DDP, subjecting them to unscientific and ideologically driven methods of drug prevention and treatment and denying access to essential medicines and services. State policy is to legitimize and encourage societal ill-treatment of PWUD. The government intentionally subjects approximately 1.7 million people to pain, suffering, and humiliation. Aimed at punishing people for using drugs and coercing people into abstinence, the official drug policy disregards the chronic nature of drug dependence. It also ignores the ineffectiveness of punitive measures in achieving the purposes for which they are officially used, that is, public safety and public health. Simultaneously, the government impedes measures that would eliminate the pain and suffering of DDP

  2. Calculation of the internal pressure of fuel rod from measurements of krypton-85 at its plenum; Calculo de la presion interna de barra combustible a partir de la medida de kripton-85 en su plenum

    Arana, I.; Doncel, N.; Casado, C.


    ENUSA carried out numerous campaigns of measurement internal pressure of fuel rod irradiated. All of them have been performed of form destructively in a hot cell laboratory which implies a time high to obtain results and a high economic cost to obtain a single data by rod, representative of the end of the irradiation. The objective of the project is to develop a non-destructive measurement and a methodology for reliable calculation that eliminates these problems.

  3. 神经内科高危患者发生压疮的相关因素分析%Analysis of related factors for pressure ulcers in high risk patients in Department of Internal Neurology

    黎华; 何凤荣; 杜玲


    Objective To explore the causes of pressure ulcers in high risk patients in Department of Internal Neurology. Methods A total of 376 patients in Neurological Intensive Care Unit whose Norton scale scores were less than or equal to 14 were observed. Results Among 376 high risk patients with pressure ulcer,35 (55 sites) had pressure ulcers. Conclusion Pressure ulcer is caused by multiple internal and external factors. The negative effects of nursing technological innovation and novel sanitary materials are the new noteworthy risk factors,and paralysis,fecal and urinary incontinence,hyperglycemia,obesity and hypoproteinemia are the main internal factors in the formation of pressure ulcers.%目的 探讨神经内科高危压疮患者发生的原因.方法 对入住神经内科重症监护病房376例诺顿评分≤14分的患者进行观察.结果 376例高危压疮患者发生压疮35例共55处.结论 压疮是内外多重因素共同导致的结果,护理技术革新及新型卫生材料使用的负面效应是压疮形成值得关注的新因素,瘫痪、大小便失禁、高血糖、肥胖、低蛋白血症等是压疮形成的主要内因.

  4. 老年高血压病病人降压效果的护理干预%The clinical effect of nursing intervention for release of pressure of senior hypertension



    Objective: To disucss the methods of nursing intervention for release of pressure of senior hypertension. Methods: Choosed 150 cases of senior hypertension to divide into study group and control ed group. The study group were treated with nursing intervention, the control ed group were treated with common nursing. Compared the resutls of QOL, SDS, ADL. Results: The results of study group were bet er than control ed group. Conclusion: Nursing intervention can improve patients’compliance to decrease complication.%目的:总结护理干预降压的方法,探讨其在老年高血压患者治疗中的作用。方法:随机选择150例在我院住院治疗的老年高血压患者,其中80例患者采取系统性护理干预为研究组。另70例患者采取一般护理为对照组。对比两组血压情况以及生活质量评分量表(QOL)、抑郁自评量表(SDS)、日常生活能力量表( ADL)等指标。结果: TG组健康教育有效率明显高于与OG组,两组存在显著性差异(P<0.05)。结论:护理干预方法能够明显提高慢性病患者遵医率,控制老年高血压患者血压,降低并发症,改善患者生活治疗。

  5. News release


    The 1st Foshan International Ceramic Industrial Exhibition successfully lowered its curtain,The 3rd bathroom space design contest close,TOTO: Hope Primary School was set up and put into use,Jiajun: Attend the annual meeting of Interior Design Academy attached to China Architectural Association,KITO: two newly-developed tiles have passed the technological appraisal

  6. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials

    Laudon M


    Full Text Available Ehud Grossman1,4, Moshe Laudon2, Nava Zisapel2,31Department of Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel; 2Neurim Pharmaceuticals Ltd, Tel Aviv, Israel and 3Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel; 4Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelBackground: Patients with nocturnal hypertension are at higher risk for cardiovascular complications such as myocardial infarction and cerebrovascular insult. Published studies inconsistently reported decreases in nocturnal blood pressure with melatonin.Methods: A meta-analysis of the efficacy and safety of exogenous melatonin in ameliorating nocturnal blood pressure was performed using a random effects model of all studies fitting the inclusion criteria, with subgroup analysis of fast-release versus controlled-release preparations.Results: Seven trials (three of controlled-release and four of fast-release melatonin with 221 participants were included. Meta-analysis of all seven studies did not reveal significant effects of melatonin versus placebo on nocturnal blood pressure. However, subgroup analysis revealed that controlled-release melatonin significantly reduced nocturnal blood pressure whereas fast-release melatonin had no effect. Systolic blood pressure decreased significantly with controlled-release melatonin (-6.1 mmHg; 95% confidence interval [CI] -10.7 to -1.5; P = 0.009 but not fast-release melatonin (-0.3 mmHg; 95% CI -5.9 to 5.30; P = 0.92. Diastolic blood pressure also decreased significantly with controlled-release melatonin (-3.5 mmHg; 95% CI -6.1 to -0.9; P = 0.009 but not fast-release melatonin (-0.2 mmHg; 95% CI -3.8 to 3.3; P = 0.89. No safety concerns were raised.Conclusion: Add-on controlled-release melatonin to antihypertensive therapy is effective and safe in ameliorating nocturnal hypertension, whereas fast-release melatonin is ineffective. It is necessary

  7. [Variations in the internal pressure of the pneumatic cuffs of endotracheal tubes according to their contents and the anesthetic mixtures used. Experimental study].

    de Santos, P; Castillo, J; Bogdanovich, A; Nalda, M A


    With the purpose of measuring pressure changes in the pneumatic cuffs of endotracheal tubes when the composition of the mixture of gases used for ventilation had to change for the same content, we designed a model of artificial respiration that consisted of a tube with a low pressure pneumatic cuff measuring 8.5 mm in inner diameter introduced in a replica of a human trachea, adjusted to two anesthetic bags. The cuff valve was connected to a pressure transducer by a three-ended stopcock and, after aspiration of its content, it was inflated with air, saline or nitrous oxide and oxygen at 60% up to a basal pressure of 20 mmHg. The tube was connected to a respirator adjusted to inflate 10 l/min at a rate of 15 insufflations/min of: oxygen 100% for 5 minutes, then nitrous oxide and oxygen at 60% for 30 minutes and oxygen 100% again for 15 minutes. When inflating the pneumatic cuff with air and ventilating with nitrous oxide and oxygen at 60%, its pressure reached a maximum mean value of 58 mmHg (190% with respect to base values). When insufflating with saline and ventilating in the same conditions, pressure reached a maximum mean value of 33 mmHg (65% with respect to base values). When the pneumatic cuff was inflated with nitrous oxide and oxygen at 60%, important changes in pressure were observed when the characteristics of the inspired gases were modified. We conclude that some method for monitoring pneumatic cuff pressure should be systematized.

  8. Energy Release Through Internal Wave Breaking

    van Haren, H.; Gostiaux, L.


    The sun inputs huge amounts of heat to the ocean, heat that would stay near the ocean's surface if it were not mechanically mixed into the deep. Warm water is less dense than cold water, so that heated surface waters "float" on top of the cold deep waters. Only active mechanical turbulent mixing can

  9. Energy Release Through Internal Wave Breaking

    van Haren, H.; Gostiaux, L.


    The sun inputs huge amounts of heat to the ocean, heat that would stay near the ocean's surface if it were not mechanically mixed into the deep. Warm water is less dense than cold water, so that heated surface waters "float" on top of the cold deep waters. Only active mechanical turbulent mixing can

  10. Pressure-driven opening of carbon nanotubes

    Chaban, Vitaly V.; Prezhdo, Oleg V.


    The closing and opening of carbon nanotubes (CNTs) is essential for their applications in nanoscale chemistry and biology. We report reactive molecular dynamics simulations of CNT opening triggered by internal pressure of encapsulated gas molecules. Confined argon generates 4000 bars of pressure inside capped CNT and lowers the opening temperature by 200 K. Chemical interactions greatly enhance the efficiency of CNT opening: fluorine-filled CNTs open by fluorination of carbon bonds at temperature and pressure that are 700 K and 1000 bar lower than for argon-filled CNTs. Moreover, pressure induced CNT opening by confined gases leaves the CNT cylinders intact and removes only the fullerene caps, while the empty CNT decomposes completely. In practice, the increase in pressure can be achieved by near-infrared light, which penetrates through water and biological tissues and is absorbed by CNTs, resulting in rapid local heating. Spanning over a thousand of bars and Kelvin, the reactive and non-reactive scenarios of CNT opening represent extreme cases and allow for a broad experimental control over properties of the CNT interior and release conditions of the confined species. The detailed insights into the thermodynamic conditions and chemical mechanisms of the pressure-induced CNT opening provide practical guidelines for the development of novel nanoreactors, catalysts, photo-catalysts, imaging labels and drug delivery vehicles.

  11. Effect of eprosartan-based therapy on systolic blood pressure and total cardiovascular risk in a large international population: preliminary report of the observational POWER study.

    Goudev, Assen; Berrou, Jean-Pascal; Pathak, Atul


    Estimation of total cardiovascular risk is useful for developing preventive strategies for individual patients. The POWER (Physicians' Observational Work on Patient Education According to their Vascular Risk) survey, a 6-month, open-label, multinational, post-marketing observational evaluation of eprosartan, an angiotensin II receptor blocker, was undertaken to assess the efficacy and safety of eprosartan-based therapy in the treatment of high arterial blood pressure in a large population recruited from 16 countries with varying degrees of baseline cardiovascular risk, and the effect of eprosartan-based therapy on total cardiovascular risk, as represented by the SCORE (Systematic Coronary Risk Assessment) or Framingham risk equations. Participating physicians recruited > 29,000 hypertensive patients whom they considered to be candidates (according to specified criteria) for treatment with eprosartan 600 mg/day, with other drugs added at the discretion of the physician. During treatment, systolic blood pressure decreased by 25.8 ± 14.4 mmHg to 134.6 ± 11.4 mmHg (P blood pressure fell by 12.6 ± 9.5 mmHg to 81.1 ± 7.6 mmHg, and pulse pressure fell by 13.2 ± 13.5 mmHg to 53.6 ± 11.4 mmHg (both P risk declined in parallel with the reduction in blood pressure. The POWER study has demonstrated, in a large and nonselected population, the feasibility and practicability of reducing total cardiovascular risk through systematic management of high blood pressure.


    Muhammad Abid


    Full Text Available In this paper result of an extensive comparative experimental study of a gasketed and non-gasketed flange joint with different assemblies with different combined load combinations is carried out to investigate joint performance i.e. joint strength and sealing capability. Actual joint load capacities are determined under both the design and proof test pressure with maximum additional external loading (axial and bending that can be applied for safe joint performance. In addition, application of combined load is also discussed in the light of equivalent pressure approach.

  13. Internationalization and migration pressure.

    Kultalahti, O


    The author first develops the concept of migration pressure, which is defined as the growth in the number of people wishing to migrate and the barriers preventing them from so doing. Both macro- and micro-level factors affecting migration pressure are identified. Historical trends in migration pressure in Finland are then discussed. The author then applies this concept to the analysis of current Finnish migration trends. The primary focus is on international migration.

  14. The impact on the environment and on the population due to the release of the patients after therapy with unsealed sources: a comparison between the new international recommendations and the Italian regulations

    Russo, A.; Speranza, A.; Storto, G.; Salvatore, M. [National Research Council, Institute of Biostructures and Bioimaging and Dep. of Biomorphological and Functional Sciences Federico-2 Univ., Napoli (Italy); Casale, M. [Federico-2 Univ., Dept. of Physics - Health Physics School, Napoli (Italy); Delia, R. [La Sapienza Univ., Faculty of Medicine, Rieti Section, Roma (Italy)


    The radiopharmaceutical therapy is the administration of unsealed sources of radioactivity designed to elicit a therapeutic response as a result of irradiation of a target human tissue. Historically, radioiodine (131 I) therapy for thyroid diseases, including hyperthyroidism as well as localized and metastatic thyroid cancer, has been the most studied and successful application of radionuclide therapy. This success has largely resulted from the high, rapid, and long-retained uptake of iodide in thyroidal tissue, whereas little uptake occurs in extra-thyroidal tissues. After diagnostic nuclear medicine procedures, precautions for the public are rarely required. In the other hand, after some therapeutic procedures, exposures to the public, patients relatives, and others should be limited. The decision to hospitalise or release a patient after the therapy with unsealed radioactive sources should be determined on an individual basis, and on the factors such as the residual activity in the patient, the patients wishes, the occupational and public exposures, cost, family and environmental aspects. The ICRP Publication 94 sets a limit for the radio nuclide activities, depending on external dose to other people, that can decide if patients may be or may not be hospitalised after the therapy. The International Commission on Radiological Protection (ICRP) has relied upon the dose limit of 1 mSv/year for the public, and the dose constraint of 5 mSv/episode for relatives, visitors, and caregivers (ICRP, 1991, 1996). These recommendations have been interpreted in various Countries, and the dose constraint has often been inappropriately interpreted as a rigid annual dose limit. As iodine-131 is a frequently used high-energy gamma emitter and has an 8-days physical half-life, it results in the largest dose to medical staff, the public, and relatives after procedures involving therapeutic administration of unsealed radionuclides. If we consider 1 mSv as the dose effective for the

  15. Press release

    Association du personnel


    Geneva, 26 April 2006 – In the framework of the current five-yearly review, the CERN Staff Association denounces a serious attack on employment conditions. Indeed, the Management of the Organization has announced that it will not raise salary levels, even though after-tax salaries in the reference sector (high-tech industry, following a decision by the Member States) in Switzerland are today on average 20% higher than those at CERN. With this decision, the ever-increasing gap between CERN and this comparator as well as other international organizations will not be reduced. In view of the apathy and deceit of the Management which reveals an obvious contempt for the efforts agreed to by the staff, a notice of strike action has been given for Friday 28 April 2006.

  16. Effect of eprosartan-based therapy on systolic blood pressure and total cardiovascular risk in a large international population: preliminary report of the observational POWER study

    Goudev A


    Full Text Available Assen Goudev,1 Jean-Pascal Berrou,2 Atul Pathak3 On behalf of the POWER Investigators1Department of Cardiology, Queen Giovanna University Hospital, Sofia, Bulgaria; 2Strategic Medical Affairs, CardioMetabolic Established Products, Abbott Products Operations AG, Allschwil, Switzerland; 3Faculte´ de Médecine et CHU Toulouse, Unité de Pharmacologie Cardiovasculaire et Autonome, Service de Pharmacologie et Cardiologie, INSERM U 1048, Université Paul Sabatier, Toulouse, FranceBackground: Estimation of total cardiovascular risk is useful for developing preventive strategies for individual patients. The POWER (Physicians' Observational Work on Patient Education According to their Vascular Risk survey, a 6-month, open-label, multinational, post-marketing observational evaluation of eprosartan, an angiotensin II receptor blocker, was undertaken to assess the efficacy and safety of eprosartan-based therapy in the treatment of high arterial blood pressure in a large population recruited from 16 countries with varying degrees of baseline cardiovascular risk, and the effect of eprosartan-based therapy on total cardiovascular risk, as represented by the SCORE® (Systematic Coronary Risk Assessment or Framingham risk equations.Methods: Participating physicians recruited > 29,000 hypertensive patients whom they considered to be candidates (according to specified criteria for treatment with eprosartan 600 mg/day, with other drugs added at the discretion of the physician.Results: During treatment, systolic blood pressure decreased by 25.8 ± 14.4 mmHg to 134.6 ± 11.4 mmHg (P < 0.001, mean diastolic blood pressure fell by 12.6 ± 9.5 mmHg to 81.1 ± 7.6 mmHg, and pulse pressure fell by 13.2 ± 13.5 mmHg to 53.6 ± 11.4 mmHg (both P < 0.01. Calculated total cardiovascular risk declined in parallel with the reduction in blood pressure.Conclusion: The POWER study has demonstrated, in a large and nonselected population, the feasibility and practicability of

  17. Aluminum corrosion product release kinetics

    Edwards, Matt, E-mail:; Semmler, Jaleh; Guzonas, Dave; Chen, Hui Qun; Toor, Arshad; Hoendermis, Seanna


    Highlights: • Release of Al corrosion product was measured in simulated post-LOCA sump solutions. • Increased boron was found to enhance Al release kinetics at similar pH. • Models of Al release as functions of time, temperature, and pH were developed. - Abstract: The kinetics of aluminum corrosion product release was examined in solutions representative of post-LOCA sump water for both pressurized water and pressurized heavy-water reactors. Coupons of AA 6061 T6 were exposed to solutions in the pH 7–11 range at 40, 60, 90 and 130 °C. Solution samples were analyzed by inductively coupled plasma atomic emission spectroscopy, and coupon samples were analyzed by secondary ion mass spectrometry. The results show a distinct “boron effect” on the release kinetics, expected to be caused by an increase in the solubility of the aluminum corrosion products. New models were developed to describe both sets of data as functions of temperature, time, and pH (where applicable)

  18. Deep geological disposal system development; mechanical structural stability analysis of spent nuclear fuel disposal canister under the internal/external pressure variation

    Kwen, Y. J.; Kang, S. W.; Ha, Z. Y. [Hongik University, Seoul (Korea)


    This work constitutes a summary of the research and development work made for the design and dimensioning of the canister for nuclear fuel disposal. Since the spent nuclear fuel disposal emits high temperature heats and much radiation, its careful treatment is required. For that, a long term(usually 10,000 years) safe repository for spent fuel disposal should be securred. Usually this repository is expected to locate at a depth of 500m underground. The canister construction type introduced here is a solid structure with a cast iron insert and a corrosion resistant overpack, which is designed for spent nuclear fuel disposal in a deep repository in the crystalline bedrock, which entails an evenly distributed load of hydrostatic pressure from undergroundwater and high pressure from swelling of bentonite buffer. Hence, the canister must be designed to withstand these high pressure loads. Many design variables may affect the structural strength of the canister. In this study, among those variables array type of inner baskets and thicknesses of outer shell and lid and bottom are tried to be determined through the mechanical linear structural analysis, thicknesses of outer shell is determined through the nonlinear structural analysis, and the bentonite buffer analysis for the rock movement is conducted through the of nonlinear structural analysis Also the thermal stress effect is computed for the cast iron insert. The canister types studied here are one for PWR fuel and another for CANDU fuel. 23 refs., 60 figs., 23 tabs. (Author)

  19. The effects of sustained release new indapamide on blood pressure and quality of life in patients with hypertension%新型帕胺缓释剂对高血压患者的血压及生存质量的影响

    郑晓荣; 王易虎; 张灿久


    Objective To observe the effects of sustained release new indapadmide on blood pressure,and to acquire with its efficacy on the living quality of patients with hypertension.Methods The 101 patients were randomly divided into B group with new indapamide and A group with old.The supine blood pressure was measured by sphygmomanometer,and the shape of whole day recorded by 24 hours dynamic sphygmometrograph before and after 6 months of experience.Results The antihypertensive effects of two medicines were both significant,patients in B group had lower mean nocturnal diastolic blood pressure by statistical analysis.The cases of the hypokalemic side in B group were fewer than that in A group.The living quality of patients in B group was improved significantly.Conclusion Both drugs have almost equal efficacy in management of the hypertension,and the new one brought less the hypokalemia and higher quality of life.

  20. Pressure activated stability-bypass-control valves to increase the stable airflow range of a Mach 2.5 inlet with 40 percent internal contraction

    Mitchell, G. A.; Sanders, B. W.


    The throat of a Mach 2.5 inlet with a coldpipe termination was fitted with a stability-bypass system. The inlet stable airflow range provided by various stability-bypass entrance configurations in alternate combination with several stability-bypass exit controls was determined for both steady-state conditions and internal transient pulses. Transient results were also obtained for the inlet with a choke point at the diffuser exit. Instart angles of attack were determined for the various stability-bypass entrance configurations. The response of the inlet-coldpipe system to internal and external oscillating disturbances was determined. Poppet valves at the stability-bypass exit provided an inlet stable airflow range of 28 percent or greater at all static and transient conditions.

  1. Assessment of a pressurizer spray valve faulty opening transient at Asco Nuclear Power Plant with RELAP5/MOD2. International Agreement Report

    Reventos, F.; Baptista, J.S.; Navas, A.P.; Moreno, P. [Asociacion Nuclear Asco, Barcelona (Spain)


    The Asociacion Nuclear Asco has prepared a model of Asco NPP using RELAP5/MOD2. This model, which include thermalhydraulics, kinetics and protection and controls, has been qualified in previous calculations of several actual plant transients. One of the transients of the qualification process is a ``Pressurizer spray valve faulty opening`` presented in this report. It consists in a primary coolant depressurization that causes the reactor trip by overtemperature and later on the actuation of the safety injection. The results are in close agreement with plant data.

  2. Fission-product releases from a PHWR terminal debris bed

    Brown, M.J.; Bailey, D.G., E-mail: [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada)


    During an unmitigated severe accident in a pressurized heavy water reactor (PHWR) with horizontal fuel channels, the core may disassemble and relocate to the bottom of the calandria vessel. The resulting heterogeneous in-vessel terminal debris bed (TDB) would likely be quenched by any remaining moderator, and some of the decay heat would be conducted through the calandria vessel shell to the surrounding reactor vault or shield tank water. As the moderator boiled off, the solid debris bed would transform into a more homogeneous molten corium pool located between top and bottom crusts. Until recently, the severe accident code MAAP-CANDU assumed that unreleased volatile and semi-volatile fission products remained in the TDB until after calandria vessel failure, due to low diffusivity through the top crust and the lack of gases or steam to flush released fission products from the debris. However, national and international experimental results indicate this assumption is unlikely; instead, high- and medium-volatility fission products would be released from a molten debris pool, and their volatility and transport should be taken into account in TDB modelling. The resulting change in the distribution of fission products within the reactor and containment, and the associated decay heat, can have significant effects upon the progression of the accident and fission-product releases to the environment. This article describes a postulated PHWR severe accident progression to generate a TDB and the effects of fission-product releases from the terminal debris, using the simple release model in the MAAP-CANDU severe accident code. It also provides insights from various experimental programs related to fission-product releases from core debris, and their applicability to the MAAP-CANDU TDB model. (author)


    周声才; 李栋; 张凤舞; 沈大富; 周东平; 郭臣业


    To resolve the problems of low gas draining rate in soft coal seam with low permeability,a new technology of improving seam permeability by pre-splitting blasting on floor rock is proposed.The process of increasing permeability is divided into two stages:firstly forms penetrative cranny area in the interaction of blasting stress wave and detonation gas; secondly forms releasing pressure area by coal-rock caving at the top of the blast cavity.Dynamic variation of blasting stress wave of different drilling intervals was researched by numerical simulation; and it is found that the influence sphere of the pre-splitting blasting is divided into smash area and penetrative cranny area.The smash area is 6 times of the diameter of blast hole; and the tensile wave caused by large diameter pores reflection plays the major role to connect fissures.The optimal space of forming unicom fissures and keeping same high destruction scope with the control hole is 0.9 meter,which is applied to gas pre-drainage engineering in a bottom road of a Chongqing coal mine.The application result shows that the gas drainage flow is 2.8 times of the original,and the gas drainage efficiency is improved by 3.75 times of the original.Besides,it is obvious that the much better results was achieved 20-30 days after blasting.%为解决重庆地区低透气性松软煤层瓦斯抽采率低的难题,提出煤层底板预裂爆破卸压增透新技术,指出其增透过程分为爆破应力波与爆生气体共同作用形成裂隙贯通区和爆破空腔顶部煤岩体垮落形成卸压带2个阶段.借助数值模拟对不同孔距爆破应力波的动态演变规律进行研究,发现预裂爆破影响范围分为粉碎区和贯通区,其中粉碎区范围约为爆破孔直径的6倍,而贯通区的形成则主要受大直径控制孔反射形成的拉伸波作用,最终得到预裂爆破形成贯穿裂隙且保持与控制孔同高破坏区间的最优孔距为0.9 m,并将该

  4. Validation of four devices: Omron M6 Comfort, Omron HEM-7420, Withings BP-800, and Polygreen KP-7670 for home blood pressure measurement according to the European Society of Hypertension International Protocol

    Topouchian J


    Full Text Available Jirar Topouchian,1 Davide Agnoletti,1 Jacques Blacher,1 Ahmed Youssef,1 Mirna N Chahine,2,3 Isabel Ibanez,3 Nathalie Assemani,3 Roland Asmar1–31Centre de Diagnostic, Hôpital Hôtel-Dieu, Paris, France; 2Faculty of Medicine of the Lebanese University, 3Foundation-Medical Research Institutes, Beirut, LebanonBackground: Four oscillometric devices, including the Omron M6 Comfort, Omron HEM-7420, Withings BP-800, and Polygreen KP-7670, designed for self-blood pressure measurement (SBPM were evaluated according to the European Society of Hypertension (ESH International Protocol Revision 2010 in four separate studies.Methods: The four devices measure brachial blood pressure (BP using the oscillometric method. The Withings BP-800 has to be connected to an Apple® iOS device such as an iPhone®, iPad®, or iPod®. The ESH International Protocol Revision 2010 includes a total number of 33 subjects. The difference between observer and device BP values was calculated for each measure. Ninety-nine pairs of BP differences were classified into three categories (≤5 mmHg, ≤10 mmHg, ≤15 mmHg. The protocol procedures were followed precisely in each of the four studies.Results: All four tested devices passed the validation process. The mean differences between the device and mercury readings were: −1.8±5.1 mmHg and −0.4±2.8 mmHg for systolic and diastolic BP, respectively, using the Omron M6 Comfort device; 2.5±4.6 mmHg and −1.2±4.3 mmHg for the Omron HEM-7420 device; −0.2±5.0 mmHg and 0.4±4.2 mmHg for the Withings BP-800 device; and 3.0±5.3 mmHg and 0.3±5.2 mmHg for the Polygreen KP-7670 device.Conclusion: Omron M6 Comfort, Omron HEM-7420, Withings BP-800, and Polygreen KP-7670 readings differing by less than 5 mmHg, 10 mmHg, and 15 mmHg fulfill the ESH International Protocol Revision 2010 requirements, and therefore are suitable for use by patients for SBPM, if used correctly.Keywords: Omron M6 Comfort, Omron HEM-7420, Withings BP-800

  5. Report of pilot study CCM.P-P1 for international comparison of absolute pressure measurements in gas from 3 × 10-9 Pa to 9 × 10-4 Pa

    Yoshida, Hajime; Arai, Kenta; Komatsu, Eiichi; Fujii, Kenichi; Bock, Thomas; Jousten, Karl


    A bilateral comparison of absolute gas pressure measurements from 3 × 10-9 Pa to 9 × 10-4 Pa was performed between the National Metrology Institute of Japan (NMIJ) and Physikalisch-Technische Bundesanstalt (PTB). It is a pilot study CCM.P-P1 for the next international comparison in this pressure range to test the stability of ultrahigh vacuum gauges (UHV gauges) as transfer standards. Two spinning rotor gauges (SRGs), an axial-symmetric transmission gauge (ATG), and an extractor gauge (EXG) were used as transfer standards. The calibration ratio of one SRG was sufficiently stable, but the other was not. This result indicates that improvements in the transport mechanism for SRG are needed. The two ionization gauges ATG and EXG, on the other hand, were sufficiently stable. Provisional equivalence of the pressures realized by the primary standards at NMIJ and PTB was found. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database The final report has been peer-reviewed and approved for publication by CCM-WGS.

  6. Conformable pressure vessel for high pressure gas storage

    Simmons, Kevin L.; Johnson, Kenneth I.; Lavender, Curt A.; Newhouse, Norman L.; Yeggy, Brian C.


    A non-cylindrical pressure vessel storage tank is disclosed. The storage tank includes an internal structure. The internal structure is coupled to at least one wall of the storage tank. The internal structure shapes and internally supports the storage tank. The pressure vessel storage tank has a conformability of about 0.8 to about 1.0. The internal structure can be, but is not limited to, a Schwarz-P structure, an egg-crate shaped structure, or carbon fiber ligament structure.

  7. News/Press Releases

    Office of Personnel Management — A press release, news release, media release, press statement is written communication directed at members of the news media for the purpose of announcing programs...

  8. 内压作用下壳体刚度对药柱强度的影响%Effect of case stiffness on the grain strength when applied internal pressure



    Based on the elastic stress solution of heavy wall cylinder to which applied both internal and external pressure, the strain and displacement of cylinder are derived in terms of the three-dimensional stress/strain relationship. In accordance with the radial displacement continuous condition at the bondline between the circular port grain and composite case, the pressure between grain and case is obtained under internal pressure. The influence of this pressure .on the stresses and strains in the grain is approached. The formulae of stress and strain are given in the grain. The results show that the hoop strain is reduced obviously on the inner surface of grain when the stiffness of case cylinder is increased and/or the parameter m is decreased. Therefore,it is suggested that the carbon fther of the medium strength and high modulus should be applied to manufacture the case for SRM used to tactical missile stzviced wnder the low temperature condition.%在厚壁圆筒内、外压强作用下弹性应力解的基础上,利用三维问题的应力-应变关系,得到了厚壁圆筒内的应变和位移表达式;由圆管型药柱与复合材料壳体连接处的径向位移连续性条件,得到了内压作用下药柱与壳体之间的压强;讨论了该压强对药柱内应力和应变的影响,给出了药柱内的应力和应变表达式.结果表明,提高壳体圆筒的刚度或减小药柱的m数,可有效减小药柱内表面的环向应变.对低温服役的战术发动机,宜采用中强高模炭纤维制作壳体.

  9. 核电厂安全壳极限抗压承载力及影响因素分析%Ultimate Capacity and Influenced Factors Analysis of Nuclear RC Containment Subj ected to Internal Pressure

    宋辰宁; 侯钢领; 周国良


    Ultimate compressive bearing capacity,influenced factors and its rules of nuclear RC containment are key problems of safety assessment,accident treatment and structure design,etc.Ultimate compressive bearing capacity of nuclear RC containment is shown by concrete damaged plasticity model and steel double liner model of ABAQUS.The study shows that the concrete of nuclear RC containment cylinder wall becomes plastic when the internal pressure is up to 0.87 MPa,the maximum tensile strain of steel liner exceeds 3000 × 106 and nuclear RC containment reaches ultimate status when the internal pressure is up to 1.02 MPa.The result shows that nuclear RC containment is in elastic condition under the design internal pressure and the bearing capacity meets requirement.Prestress and steel liner play key parts in the ultimate internal pressure and failure mode of nuclear RC containment.The study results have value for the analysis of ultimate compressive bearing capacity,structure design and safety assessment.%核电厂安全壳极限抗压承载力、影响因素及其规律是核电结构安全评估、事故处理和结构设计的关键问题。本文以某安全壳为例,采用损伤塑性模型模拟混凝土的力学性能,双线形应力-应变模型模拟钢衬里和预应力钢束的材料非线性,基于 ABAQUS软件系统地分析了核安全壳极限抗压承载力,并给出了结构自重、预应力、钢衬里等因素的影响规律。研究表明,当内压增大到0��87 MP a 时,安全壳筒壁上部混凝土开始进入塑性;当内压增大到1��02 MPa时,钢衬里最大拉应变超过限值3000×10-6,安全壳达到极限状态。在各种影响因素中,预应力和钢衬里对安全壳的极限内压和破坏形式起着关键作用。本文研究结果对核安全壳极限承载能力分析、结构设计和安全评定等方面具有一定的参考价值。

  10. Analysis of an Aircraft Honeycomb Sandwich Panel with Circular Face Sheet/Core Disbond Subjected to Ground-Air Pressurization

    Rinker, Martin; Krueger, Ronald; Ratcliffe, James


    The ground-air pressurization of lightweight honeycomb sandwich structures caused by alternating pressure differences between the enclosed air within the honeycomb core and the ambient environment is a well-known and controllable loading condition of aerospace structures. However, initial face sheet/core disbonds intensify the face sheet peeling effect of the internal pressure load significantly and can decrease the reliability of the sandwich structure drastically. Within this paper, a numerical parameter study was carried out to investigate the criticality of initial disbonds in honeycomb sandwich structures under ground-air pressurization. A fracture mechanics approach was used to evaluate the loading at the disbond front. In this case, the strain energy release rate was computed via the Virtual Crack Closure Technique. Special attention was paid to the pressure-deformation coupling which can decrease the pressure load within the disbonded sandwich section significantly when the structure is highly deformed.

  11. 密封Cd/Ni电池内压问题的实验与分析%Analysis and experiment for problems of internal pressure of sealing nickel-cadmium battery



    The results of experiments and the point of view reported in someliteratures about the problem of internal pressure in sealing alkaline accumulator were collected and some differences in them were analysed.It was indicated that it should be careful to use the conception of catalysis in respect to the positive effect of adding Ag and C into cadmium electrode for increasing oxygen recombination.At the same time,the results of the experiment showed that under the condition of an optimized structure of cadmium electrode,the internal pressure of the test sealing nickel cadmium battery tested could be minimized to lower than 0.02 MPa in all period of charge at 0.2C.%分析了有关碱性密封蓄电池内气压问题的实验结果和结论,讨论了它们之间的差异及其产生的条件。指出有关在镉电极中添加银、碳等有助于氧复合的正面效果时应慎重引用“催化”的概念。本工作实验结果表明,在优化镉电极条件下,密封Cd/Ni实验电池的内气压在充电全过程中可能降至0.02MPa以下,而且瞬间即逝。

  12. Impacts of an Ammonia Leak on the Cabin Atmosphere of the International Space Station

    Duchesne, Stephanie M.; Sweterlitsch, Jeffrey J.; Son, Chang H.; Perry Jay L.


    Toxic chemical release into the cabin atmosphere is one of the three major emergency scenarios identified on the International Space Station (ISS). The release of anhydrous ammonia, the coolant used in the U.S. On-orbit Segment (USOS) External Active Thermal Control Subsystem (EATCS), into the ISS cabin atmosphere is one of the most serious toxic chemical release cases identified on board ISS. The USOS Thermal Control System (TCS) includes an Internal Thermal Control Subsystem (ITCS) water loop and an EATCS ammonia loop that transfer heat at the interface heat exchanger (IFHX). Failure modes exist that could cause a breach within the IFHX. This breach would result in high pressure ammonia from the EATCS flowing into the lower pressure ITCS water loop. As the pressure builds in the ITCS loop, it is likely that the gas trap, which has the lowest maximum design pressure within the ITCS, would burst and cause ammonia to enter the ISS atmosphere. It is crucial to first characterize the release of ammonia into the ISS atmosphere in order to develop methods to properly mitigate the environmental risk. This paper will document the methods used to characterize an ammonia leak into the ISS cabin atmosphere. A mathematical model of the leak was first developed in order to define the flow of ammonia into the ISS cabin atmosphere based on a series of IFHX rupture cases. Computational Fluid Dynamics (CFD) methods were then used to model the dispersion of the ammonia throughout the ISS cabin and determine localized effects and ventilation effects on the dispersion of ammonia. Lastly, the capabilities of the current on-orbit systems to remove ammonia were reviewed and scrubbing rates of the ISS systems were defined based on the ammonia release models. With this full characterization of the release of ammonia from the USOS TCS, an appropriate mitigation strategy that includes crew and system emergency response procedures, personal protection equipment use, and atmosphere monitoring

  13. Analysis of the Internal and External Flow Fields of High Pressure Water Jet Nozzle in Radial Drilling%径向钻井高压水射流喷嘴内外流场分析

    易松林; 汪志明; 孙怡红; 易先中; 吉源强; 刘利军


    The technology of high pressure water jet in radial drilling has currently been used widely at home and abroad. A numerical simulation and analysis of the internal and external flow fields of jet nozzle will lay the foundation for the further study of selection of rational nozzle structure as well as for high pressure water jet rock breaking. According to the jet dynamic principle, the physical and mathematical models of axial - symmetrical submerged jet rock breaking with single nozzle were established. A numerical simulation of the internal and external flow fields of high pressure water jet nozzle in radial drilling was conducted with the Fluent software. The laws of the internal and external flow fields were analyzed in different jet distances and inlet flowrates. The analysis shows that there exist velocity attenuation, velocity retention in the cylindrical section and migration in the maximum speed. When the jet flow impacts into the radial hole bottom, the water cushion will occur on the bottomhole wall surface. This will produce a barrier to nozzle advance. Stagnation will arise in high pressure water jet for radial drilling. This will be unfavorable to the transportation of cuttings in the drilling process.%径向钻井高压水射流技术目前在国内外得到了广泛应用.对射流喷嘴内、外流场进行数值模拟分析将为选择合理的喷嘴结构以及为高压水射流破岩的进一步研究奠定基础.根据射流动力学原理,建立了单喷嘴轴对称淹没射流破岩的物理模型和数学模型,运用Fluent软件对径向钻井高压水射流喷嘴内、外流场进行了数值模拟,并分析了在不同喷距和入口流量下喷嘴内、外流场的规律.分析结果表明,射流轴线上存在速度衰减性、圆柱段速度保持性和最大速度偏移性;当射流冲击到径向井底后,在井底壁面上产生水垫,对喷头的推进产生阻碍作用;在径向钻井高压水射流中会产生滞止现象,

  14. Modified-Release Recombinant Human TSH (MRrhTSH) Augments the Effect of 131I Therapy in Benign Multinodular Goiter: Results from a Multicenter International, Randomized, Placebo-Controlled Study

    Graf, H; Fast, S; Pacini, F


    Background: Recombinant human TSH (rhTSH) can be used to enhance (131)I therapy for shrinkage of multinodular goiter (MG). Objective, Design, and Setting: The objective of the study was to compare the efficacy and safety of 0.01 and 0.03 mg modified-release (MR) rhTSH as an adjuvant to (131)I the...

  15. Long-term efficacy of modified-release recombinant human TSH (MRrhTSH) augmented radioiodine (131I) therapy for benign multinodular goiter. Results from a multicenter international, randomized, placebo-controlled dose-selection study

    Fast, Søren; Hegedus, Laszlo; Pacini, Furio


    Background: Enhanced reduction of multinodular goiter (MNG) can be achieved by stimulation with recombinant human thyrotropin (rhTSH) before radioiodine (131I) therapy. The objective was to compare the long-term efficacy and safety of two low doses of modified release rhTSH (MRrhTSH) in combinati...

  16. 非对称冲击-卸载实验中纵波声速的特征线分析方法%Characteristic metho d to infer the high-pressure sound sp eed in a nonsymmetric impact and release exp eriment

    潘昊; 吴子辉; 胡晓棉


    Sound speed is of great importance for high velocity impact phenomena because it is a fundamental parameter to deduce the shear moduli, strengths and phase transitions of materials at high pressure. It has attracted much attention because of significant challenges to experiment and simulation. In practice, with the development of laser interferometer measurement system, one can obtain velocity-time histories of windowed-surfaces or free surfaces with high resolution in shock or ramp compression and unload experiments. This development provides a possible way to infer the sound speed from these velocity profiles. The key problem is to build valid analysis technique to extract the sound speed. Commonly used Lagrangian analysis methods include backward integration method, incremental impedance matching method, transfer function method and backward characteristic analysis method. However, all of these methods hardly infer the right results from the nonsymmetric impact and release experiment with only one depth of material due to the complex impedance mismatch among a flyer, sample and window. Some decreasing impedance mismatch techniques have been developed for the experiments including reverse impact or using a high strength flyer, but these techniques will limit the pressure range or need a newly designed gun with large caliber. In fact, the traditional backward characteristic analysis method only considers the sample/window interaction while bending of the incoming characteristics due to impedance difference between the flyer and sample is always ignored, which causes a distortion to the loading condition of samples. Thus in this work, we add forward characteristics to describe rarefaction wave reflection at the flyer/sample interface. Then a reasonable loading-releasing in-situ velocity profile of the interface can be derived from this improvement. We use the improved/tradition characteristics and incremental impedance matching method to analyze a synthetic

  17. Mechanisms of renin release from juxtaglomerular cells

    Skøtt, O; Salomonsson, Max; Sellerup Persson, Anja;


    In microdissected, nonperfused afferent arterioles changes in intravascular pressure did not affect renin secretion. On the contrary, renin release from isolated afferent arterioles perfused in a free-flow system has been reported to be sensitive to simultaneous changes in luminal pressure and flow....... Hence local blood flow may be involved in the baroreceptor control of renin release. If flow is sensed, the sensor is likely to be located near the endothelial cell layer, where ion channels have been shown to be influenced by variations in shear stress....

  18. "Sustained release formulation of Metoclopramide Hydrochloride "

    Dabbagh MA


    Full Text Available In this research, several formulations containing, an anti emetic agent (Metoclopramide hydrochloride, a hydrophilic polymer (hydroxypropylmethylcellulose and a hydrophobic polymer (ethylcellulose 10 cP were prepared by direct compression. Different factors such as: the effect of different ratios of the polymers, particle size, pressure force and differences of release in acidic and distilled water as media were investigated. After developing the ideal formulation, the effect of changing the ratio of drug in core: coating on the formulation was investigated. Coating of tablets with ethylcellulose, changed the release mechanism of drug and shifted it to near zero order release. The results showed that except when matrices were coated with ethylcellulose, drug release was proportioned to the square root of time, which might be due to the change of release pattern from matrix to reservoir system.

  19. Pressure ulcers

    Reddy, Madhuri


    Unrelieved pressure or friction of the skin, particularly over bony prominences, can lead to pressure ulcers in up to one third of people in hospitals or community care, and one fifth of nursing home residents...

  20. Pressure Sores

    Pressure sores are areas of damaged skin caused by staying in one position for too long. They ... wheelchair, or are unable to change your position. Pressure sores can cause serious infections, some of which ...

  1. Medications and International Travel


    This podcast answers a listener's question about her medications and an international trip she's planning.  Created: 4/12/2011 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 4/12/2011.

  2. Toxics Release Inventory (TRI)

    U.S. Environmental Protection Agency — The Toxics Release Inventory (TRI) is a dataset compiled by the U.S. Environmental Protection Agency (EPA). It contains information on the release and waste...

  3. Pressure ulcers

    Monfre, Jill M.


    Unrelieved pressure or friction of the skin, particularly over bony prominences, can lead to pressure ulcers, which affect up to one third of people in hospitals or community care, and one fifth of nursing home residents. Pressure ulcers are more likely in people with reduced mobility and poor skin condition, such as older people or those with vascular disease.

  4. Feasibility investigations on a novel micro-manufacturing process for fabrication of fuel cell bipolar plates: Internal pressure-assisted embossing of micro-channels with in-die mechanical bonding

    Koc, Muammer [NSF I/UCR Center for Precision Forming (CPF), Department of Mechanical Engineering, Virginia Commonwealth University (VCU), Richmond, VA (United States); Mahabunphachai, Sasawat [NSF I/UCR Center for Precision Forming (CPF), Department of Mechanical Engineering, Virginia Commonwealth University (VCU), Richmond, VA (United States); Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI (United States)


    In this paper, we present the results of our studies on conceptual design and feasibility experiments towards development of a novel hybrid manufacturing process to fabricate fuel cell bipolar plates that consists of multi-array micro-channels on a large surface area. The premises of this hybrid micro-manufacturing process stem from the use of an internal pressure-assisted embossing process (cold or warm) combined with mechanical bonding of double bipolar plates in a single-die and single-step operation. Such combined use of hydraulic and mechanical forming forces and in-process bonding will (a) enable integrated forming of micro-channels on both surfaces (as anode and cathode flow fields) and at the middle (as cooling channels), (b) reduce the process steps, (c) reduce variation in dimensional tolerances and surface finish, (d) increase the product quality, (e) increase the performance of fuel cell by optimizing flow-field designs and ensuring consistent contact resistance, and (f) reduce the overall stack cost. This paper explains two experimental investigations that were performed to characterize and evaluate the feasibility of the conceptualized manufacturing process. The first investigation involved hydroforming of micro-channels using thin sheet metals of SS304 with a thickness of 51 {mu}m. The width of the channels ranged from 0.46 to 1.33 mm and the height range was between 0.15 and 0.98 mm. Our feasibility experiments resulted in that different aspect ratios of micro-channels could be fabricated using internal pressure in a controllable manner although there is a limit to very sharp channel shapes (i.e., high aspect ratios with narrow channels). The second investigation was on the feasibility of mechanical bonding of thin sheet metal blanks. The effects of different process and material variables on the bond quality were studied. Successful bonding of various metal blanks (Ni201, Al3003, and SS304) was obtained. The experimental results from both

  5. Modelo por elementos finitos de un tubo a presión interna con una grieta transversal parcial // Partial transverse crack modelling in pipes under internal pressure using finite elements.

    Freddy Enrique Rodríguez


    Full Text Available ResumenLa detección de defectos en tubos sometidos a presión interna es un aspecto poco estudiado. Uno de los problemas a resolver es el modelado de los defectos, en particular los del tipo grieta cerrada.La dinámica de un tubo con un fluido interno a presión implica dificultades adicionales al problema.Se presentan los principios y las ecuaciones necesarias para poder modelar por el método de los elementos finitos la presencia de una grieta transversal parcial en un tubo de paredes delgadas en varios escenarios: vacío, con un fluido interno y con un fluido a presión. El análisis modal es empleado para determinar los cambios en los parámetros del modelo y valorar la influencia de la grieta en los mismos. Se parte del experimento de S.M. Murigendrappa y S.K. Maiti, el efecto de la grieta está representado por una reducción de la rigidez a la flexión del tubo en la zona de extensión d, cuya extensión es determinada a partir del concepto de energía potencial de la deformación,planteado por A P. Bovsunovsky y V. V. Matveev.Palabras claves: grieta cerrada, análisis modal, tubos, elementos finitos._______________________________________________AbstractFail detection in pipes under internal pressure is a not enough studied matter. A main problem is fault modeling, particularly the closed crack type. The dynamic of a pipe filled with a fluid under pressure implies additional challenges. The equations and principles needed to obtain a finite elements model of a partial transverse crack in a thin walled pipe are shown in different sceneries: empty, filled with fluid and filled with fluid under certain pressure. A modal analysis is performed to obtain the changes in modal parameters and crack influence. The result shows a good agreement with those obtained by S.M. Murigendrappa and S.K. Maiti. The crack is modeled trough a reduction of bending stiffness in a reduced zone. Its extension is calculated using the principle of equal strain

  6. 压力源量表对本科护理实习生的指导意义及对策%The Countermeasure and Guiding Signiifcande of Undergraduate Course Nurse Intern by Pressure Source Scale

    金瑞阳; 欧伟伟


    Objective To explore the stress source and coping style of the undergraduate nursing students, and the methods of psychological stress reduction for the nursing students to keep their physical and mental health. Methods The pressure source and coping style of 160 male and female, undergraduate nursing interns were investigated by using the psychological pressure source scale and questionnaire.Results 32.84% of the nursing students have high level of stress, the main source of the pressure of nursing work is too hard, income and pay no matching, employment and high risk of nursing career. In terms of stress response, nursing students mostly adopt positive coping style, the most used is to talk with people, talk heart troubles, sports.Conclusion There are many kinds of psychological stress sources in undergraduate nursing students. The nursing educators should take the method of consolidating the professional thought, giving psychological support and so on.%目的:了解护理本科业实习生的压力源和应对方式,了解护理实习生的压力总体水平和主要压力源,探讨积极应对实习压力的措施,缓解护理实习生压力,保持身心健康。方法采用心理压力源量表和问卷调查,对160例男、女本科护理专业实习生的压力源和应对方式进行调查。结果32.84%的护生具有较高水平的压力,其压力主要来源于就业、自身知识和能力、护理工作过于辛劳、收入与付出不匹配、护理职业的高风险等方面。在压力应对方面,护生大多采取积极的应对方式,采用最多的是运动、寻求支持倾诉内心烦恼等方式。结论护理本科实习生在临床实习过程中面临多种心理压力源,护理教育者应采取正确引导,巩固专业思想、给予心理支持等方法减轻其压力。

  7. DIREPI: Sistema para el cálculo a resistencia de recipientes sometidos a presión interna // DIREPI: System for the resistance calculation of recipients with internal pressure

    L. S. Flores Bernal


    Full Text Available El trabajo muestra la confección de un software para el cálculo a resistencia de recipientes sometidos a presión interna y construidosde acero, aborda también las ventajas que reporta el tener automatizado la metodología de trabajo por la calidad de los resultadosfinales que se obtienen y la fiabilidad de los mismos, el sistema posee una salida gráfica por AutoCAD que permite obtener losplanos de taller de los componentes de los recipientes diseñados.Palabras claves: CADD, CAD, diseño, cálculo de recipientes._________________________________________________________________________________AbstractThe work shows the making of a software for the calculation to resistance of steel recipients with internal pressure, it also approachesthe advantages that reports having automated the work methodology, the system has a graphic result for AutoCAD that allows toobtain the blueprinters of the components of the designed recipients.Key words: CADD, AutoCAD, design, calculation of recipients.

  8. Deformation and failure behaviour of pipe bends subject to internal pressure and constant additional moment in the creep range; Verformungs- und Versagensverhalten von Rohrbogen unter Innendruck und konstantem Zusatzmoment im Kriechbereich

    Kussmaul, K. [Staatliche Materialpruefungsanstalt (MPA), Univ. Stuttgart (Germany); Maile, K. [Staatliche Materialpruefungsanstalt (MPA), Univ. Stuttgart (Germany); Purper, H. [Staatliche Materialpruefungsanstalt (MPA), Univ. Stuttgart (Germany)


    A series of failures on pipe bends, which occurred in the creep range, necessitated the carrying out of the research project `Internal pressure tests on pipe bends of heat-resistant steels with additionally applied bending moments at temperatures within the creep range` for the formulation of principles and regulations for qualifying design and expert assessment of creep-stressed pipe bends. The incidence of failure on pipe bends can be described on the basis of the results obtained (assessment of cause of damage, characterization of time-dependent stress condition); therefore a catastrophic failure can be excluded by monitoring of pipe bends. Proposals for revising the existing regulation (TRD 301) are focussed on avoiding this kind of damage. (orig.) [Deutsch] Eine Reihe von Schaeden an Rohrbogen, die im Zeitstandbereich beansprucht waren, erforderten die Durchfuehrung des Forschungsvorhabens `Innendruckversuche an Rohrbogen aus warmfesten Staehlen mit zusaetzlich aufgebrachten Biegemonmenten bei Temperaturen im Kriechbereich` zur Schaffung von Grundlagen und Regeln fuer eine qualifizierte Auslegung und Begutachtung kriechbeanspruchter Rohrbogen. Auf der Grundlage der erzielten Ergebnisse (Bewertung des Schaedigungsablaufes, Charakterisierung des zeitabhaengigen Beanspruchungszustandes) ist der Versagensablauf an Rohrbogen beschreibbar; es kann daher in der Ueberwachung von Rohrbogen ein katastrophales Versagen ausgeschlossen werden. Vorschlaege zur Modifizierung des bestehenden Regelwerkes (TRD 301) konzentrieren sich darauf, derartige Schaeden zu vermeiden. (orig.)


    Michelson, C.


    An electromagnetic release mechanism is offered that may be used, for example, for supporting a safety rod for a nuclear reactor. The release mechanism is designed to have a large excess holding force and a rapid, uniform, and dependable release. The fast release is accomplished by providing the electromagnet with slotttd polts separated by an insulating potting resin, and by constructing the poles with a ferro-nickel alloy. The combination of these two features materially reduces the eddy current power density whenever the magnetic field changes during a release operation. In addition to these features, the design of the armature is such as to provide ready entrance of fluid into any void that might tend to form during release of the armature. This also improves the release time for the mechanism. The large holding force for the mechanism is accomplished by providing a small, selected, uniform air gap between the inner pole piece and the armature.

  10. DVD With High Gapacity Released


    After two years of research and development, the Center for International Cultural Exchange under the Ministry of Culture of China has recently released a new type of DVD which is double-faced, double-system and bears ten languages. Teststatistics show that all its indicators come up withthose of its foreign counterparts. Now it has beenput into mass production.This new type of DVD features the following performances. It is a high-clarity one, with the horizontal clarity more than 500. It has a superb sound effect, capable of recording various stereo signals such as DOLBY DIGITAL and DTS. It can record dubbing in eight languages and subtitles

  11. CH4 release character from pressurized fast pyrolysis of lignite in CO atmosphere%CO气氛下褐煤加压快速热解过程中CH4的逸出规律

    高松平; 王建飞; 赵建涛; 王志青; 房倚天; 黄戒介


    在管式反应器上进行了霍林河褐煤加压快速热解实验,研究了CO气氛下CH4逸出规律。在加压快速热解条件下,由于CO解离态吸附的O( a)吸附在煤上,提供了活性中心,电负性强的O( a)诱发其周围其他原子的电子云向O( a)偏移,减弱了原来化学键的强度,导致芳香环的开裂,侧链、醚键和脂肪链的断裂提供更多的自由基,稳定煤热解生成的碎片,促进了CH4的生成和逸出。因此,CO气氛下CH4产率较N2气氛下的高,在900℃、1.0 MPa时,50%CO气氛下的CH4产率较N2气氛下的提高了12.5%,并且CH4产率随着温度升高、压力的增大而增大。%Fast pyrolysis of Huolinhe lignite was carried out under pressure in a tubular reactor, and the CH4 evolution at CO atmosphere was examined. CO dissociation state O( a) adsorbed on coal is an active center. The stronger electronegative O could induce the electron cloud of other atoms around O ( a ) atom to offset to it, which could weaken the strength of original chemical bonds and promote their breaking. These result in the cracks of the aromatic ring, side chain, ether linkages and aliphatic chain in the char, which could produce more free radicals. The free radicals could stabilize the fragments produced in the pyrolysis, and lead to more CH4 generated and involved. Therefore, the CH4 yield is higher under CO than it in N2 . The CH4 yield increases by 12. 5% under CO compared with N2 at 900℃ and 1. 0 MPa. The CH4 yield increases with raise of temperature and pressure.

  12. Investigation and modelling of release and transport processes of alkaline substances in high-pressure coal combustion processes. Final report; Untersuchung und Modellierung der Freisetzungs- und Transportvorgaenge von Alkalien bei der Kohleverbrennung unter hohen Druecken. Abschlussbericht

    Kremer, H.; Wirtz, S.; Mueller, C.; Murza, S.; Scheuer, S.; Mohr, M.


    On the basis of IWE and DMT-FuelTec measurements on the release of alkaline components in coal dust combustion processes, a model for mathematical description of these processes was developed at LEAT and was integrated in the LEAT CFD code LORA. This required extensive further development and enhancement of the basic program available at the beginning of the project, especially the parallelization of the Lagrangian particle trackings and the improvement and enhancement of the description of the chemical and physical particle reactions. As a comparison with measurements showed, this results in an acceptably accurate description of the processes. The results of the project were applied in further LEAT projects and were also supported by experimental projects, making use of synergies and achieving clear progress in the description of combustion systems. Further developments of the model components are already used in industrial applications. [German] Auf der Grundlage von bei IWE und DMT-FuelTec durchgefuehrten Messungen zur Freisetzung von Alkalikomponenten bei der Kohlenstaubverbrennung ist am LEAT ein Modellansatz zur mathematischen Beschreibung dieser Vorgaenge entwickelt und in den am LEAT entwickelten CFD-Code LORA integriert worden. Dazu war eine umfangreiche Weiterentwicklung und Ergaenzung des zu Projektbeginn vorhandenen Basisprogramms notwendig. Dies betraf vor allem die Parallelisierung des Lagrange'schen Partikeltrackings und die Verbresserung bzw. Erweiterung der Beschreibung der chemischen und physikalischen Partikelreaktionen. Wie der Vergleich mit Messungen zeigt [9, 36], ist damit eine brauchbare Beschreibung der Vorgaenge moeglich. Die in diesem theoretisch orientierten Projekt erarbeiteten Ergebnisse sind sowohl in weitere Projekte des LEAT eingeflossen, als auch durch andere, experimentell ausgerichtete Projekte unterstuetzt worden. Insgesamt wurden dadurch Synergien genutzt und ein deutlicher Fortschritt bei der Beschreibung entsprechender

  13. Investigation and modelling of the alkaline release and transport during coal combustion at elevated pressures. Final report; Untersuchung und Modellierung der Freisetzungs- und Transportvorgaenge von Alkalien bei der Kohleverbrennung unter hohen Druecken. Untersuchungen mit der Hochdruck-Hochtemperatur-Thermowaage, Alkalienanalysen in Rohkohlen und Feuerungsversuche in der Druckwirbelschichtanlage FRED (DMT). Abschlussbericht

    Bonn, B.; Steffin, C.; Busch, U.; Mayer, M.


    In this joint research project DMT investigated the release (and incorporation) of alkalis of the coal mineral matter to clear up the affecting mechanisms during combustion at elevated pressure. In the experiments parameter like the ambient gas and the ash composition, pressure and heating rate were varied. The experiments were conducted in DMT's high-temperature and high-pressure Thermogravimetric-Analyser (TGA) and the DMT Pressurised Fluidised Bed Combustor (PFBC). TGA-Experiments: A model compounds for the alkali sodium chloride and for the mineral matter metakaoline were used. The chemical properties (basicity) of metakaoline was modified by adding CaO. The commonly accepted physical volatilization process of the alkali from the ash was not confirmed by TGA experiments. The alkali release must be regarded as a desorption mechanism of the sodium chloride from the metakaoline surface. The desorption of the alkali is not affected by chemical composition of the mineral matter but is strongly influenced by gas phase oxygen species and pressure. PFBC-Experiments: The rig was operated with a fluidised bed temperature of 920 C and a pressure of 7 bar. The online/in-situ alkali detection was based on the excimer laser induced fragmentation fluorescence ELIF. The alkali content of the coal was varied by addition of sodium acetate and sodium chloride. Kaoline was used as gettermaterial for mitigation of alkali emissions. Furthermore, the influence of limestone on the alkali release was investigated. Among other results, the experiments showed that the alkali emissions of the lignite are 50-100 times higher than those of the bituminous coal and if limestone for capturing SO{sub 2} is added to the combustor the alkali chloride emissions increase rapidly. (orig.) [German] Im Rahmen des o.g. Gemeinschaftsprojekts untersuchte die DMT die Freisetzung (und Einbindung) der Alkalien aus der Mineralsubstanz von Kohlen zur Aufklaerung der beeinflussenden Mechanismen bei der

  14. Vital Signs - High Blood Pressure


    In the U.S., nearly one third of the adult population have high blood pressure, the leading risk factor for heart disease and stroke - two of the nation's leading causes of death.  Created: 10/2/2012 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/17/2012.

  15. Peer Pressure

    ... who are unsure of themselves, new to the group, or inexperienced with peer pressure may also be more likely to give in. ... stand that makes you look uncool to your group. But these situations can be ... up to peer pressure, but it does take courage — yours: Listen to ...

  16. Release the Body, Release the Mind.

    Stoner, Martha Goff


    A college English teacher describes the anxiety and resentment of students during in-class writing assignments and the successful classroom use of meditation and body movement. Movement seemed to relax the students, change their attitudes, and release their creative impulses to write. Implications related to the body-mind connection are pondered.…

  17. Wrinkling of Pressurized Elastic Shells

    Vella, Dominic


    We study the formation of localized structures formed by the point loading of an internally pressurized elastic shell. While unpressurized shells (such as a ping-pong ball) buckle into polygonal structures, we show that pressurized shells are subject to a wrinkling instability. We study wrinkling in depth, presenting scaling laws for the critical indentation at which wrinkling occurs and the number of wrinkles formed in terms of the internal pressurization and material properties of the shell. These results are validated by numerical simulations. We show that the evolution of the wrinkle length with increasing indentation can be understood for highly pressurized shells from membrane theory. These results suggest that the position and number of wrinkles may be used in combination to give simple methods for the estimation of the mechanical properties of highly pressurized shells. © 2011 American Physical Society.

  18. First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 3: Porcine islet product manufacturing and release testing criteria.

    Rayat, Gina R; Gazda, Lawrence S; Hawthorne, Wayne J; Hering, Bernhard J; Hosking, Peter; Matsumoto, Shinichi; Rajotte, Ray V


    In the 2009 IXA consensus, the requirements for the quality and control of manufacturing of porcine islet products were based on the U.S. regulatory framework where the porcine islet products fall within the definition of somatic cell therapy under the statutory authority of the U.S. Food and Drug Administration (FDA). In addition, porcine islet products require pre-market approval as a biologic product under the Public Health Services Act and they meet the definition of a drug under the Federal Food, Drug, and Cosmetic Act (FD&C Act). Thus, they are subject to applicable provisions of the law and as such, control of manufacturing as well as reproducibility and consistency of porcine islet products, safety of porcine islet products, and characterization of porcine islet products must be met before proceeding to clinical trials. In terms of control of manufacturing as well as reproducibility and consistency of porcine islet products, the manufacturing facility must be in compliance with current Good Manufacturing Practices (cGMP) guidelines appropriate for the initiation of Phase 1/2 clinical trials. Sponsors intending to conduct a Phase 1/2 trial of islet xenotransplantation products must be able to demonstrate the safety of the product through the establishment of particular quality assurance and quality control procedures. All materials (including animal source and pancreas) used in the manufacturing process of the porcine islet products must be free of adventitious agents. The final porcine islet product must undergo tests for the presence of these adventitious agents including sterility, mycoplasma (if they are cultured), and endotoxin. Assessments of the final product must include the safety specifications mentioned above even if the results are not available until after release as these data would be useful for patient diagnosis and treatment if necessary. In addition, a plan of action must be in place for patient notification and treatment in case the

  19. Member end releases in framed structures

    Stallings, J. M.


    Discontinuities such as internal hinges are commonly encountered in framed structures. A general method of including discontinuities in stiffness method analyses of planar frames by the release of member end forces is developed. Modifications are made to the member stiffness matrix and equivalent joint load vector to account for the released end forces. A FORTRAN algorithm is given that makes the necessary modifications to the member stiffness matrix and equivalent joint load vector for the standard planar frame member. The algorithm allows combinations of up to three member end forces to be released (specified at zero or nonzero values). An algorithm is also given that calculates the unknown member end displacements at the released member end forces. Numerical examples are given to illustrate the uses and capabilities of the algorithms.

  20. Fission Product Release and Survivability of UN-Kernel LWR TRISO Fuel

    Besmann, Theodore M [ORNL; Ferber, Mattison K [ORNL; Lin, Hua-Tay [ORNL


    A thermomechanical assessment of the LWR application of TRISO fuel with UN kernels was performed. Fission product release under operational and transient temperature conditions was determined by extrapolation from range calculations and limited data from irradiated UN pellets. Both fission recoil and diffusive release were considered and internal particle pressures computed for both 650 and 800 m diameter kernels as a function of buffer layer thickness. These pressures were used in conjunction with a finite element program to compute the radial and tangential stresses generated with a TRISO particle as a function of fluence. Creep and swelling of the inner and outer pyrolytic carbon layers were included in the analyses. A measure of reliability of the TRISO particle was obtained by measuring the probability of survival of the SiC barrier layer and the maximum tensile stress generated in the pyrolytic carbon layers as a function of fluence. These reliability estimates were obtained as functions of the kernel diameter, buffer layer thickness, and pyrolytic carbon layer thickness. The value of the probability of survival at the end of irradiation was inversely proportional to the maximum pressure.

  1. Investigation of Burst Pressures in PWR Primary Pressure Boundary Components

    Ihn Namgung


    Full Text Available In a reactor coolant system of a nuclear power plant (NPP, an overpressure protection system keeps pressure in the loop within 110% of design pressure. However if the system does not work properly, pressure in the loop could elevate hugely in a short time. It would be seriously disastrous if a weak point in the pressure boundary component bursts and releases radioactive material within the containment; and it may lead to a leak outside the containment. In this study, a gross deformation that leads to a burst of pressure boundary components was investigated. Major components in the primary pressure boundary that is structurally important were selected based on structural mechanics, then, they were used to study the burst pressure of components by finite element method (FEM analysis and by number of closed forms of theoretical relations. The burst pressure was also used as a metric of design optimization. It revealed which component was the weakest and which component had the highest margin to bursting failure. This information is valuable in severe accident progression prediction. The burst pressures of APR-1400, AP1000 and VVER-1000 reactor coolant systems were evaluated and compared to give relative margins of safety.

  2. Prediction of release ratios of multicomponent pheromones from rubber septa.

    Heath, R R; Teal, P E; Tumlinson, J H; Mengelkoch, L J


    A method has been developed to predict the release ratio of the components of blends of alcohols, acetates, and/or aldehydes from rubber septa. The calculations of predicted release ratios are based on the relative vapor pressures of the components. The relative vapor pressures of the compounds were calculated from their retention indices on a liquid crystal capillary gas chromatographie column. The correlation between the theoretically predicted and experimentally determined ratios was very good. Thus, formulations can be prepared that will release a desired ratio of the components of a multicomponent pheromone blend.

  3. Estimation of turgor pressure through comparison between single plant cell and pressurized shell mechanics

    Durand-Smet, P.; Gauquelin, E.; Chastrette, N.; Boudaoud, A.; Asnacios, A.


    While plant growth is well known to rely on turgor pressure, it is challenging to quantify the contribution of turgor pressure to plant cell rheology. Here we used a custom-made micro-rheometer to quantify the viscoelastic behavior of isolated plant cells while varying their internal turgor pressure. To get insight into how plant cells adapt their internal pressure to the osmolarity of their medium, we compared the mechanical behavior of single plant cells to that of a simple, passive, pressurized shell: a soccer ball. While both systems exhibited the same qualitative behavior, a simple mechanical model allowed us to quantify turgor pressure regulation at the single cell scale.

  4. Factors controlling alkalisalt deposition in recovery boiler- release mechanisms

    McKeough, P.; Kylloenen, H.; Kurkela, M. [VTT Energy, Espoo (Finland). Process Technology Group


    As part of a cooperative effort to develop a model to describe the behaviour of inorganic compounds in kraft recovery boilers, an experimental investigation of the release of sulphur during black liquor pyrolysis has been undertaken. Previous to these studies, the mechanisms of sulphur release and the reasons for the observed effects of process conditions on sulphur release were very poorly understood. On the basis of the experimental results, the main reactions leading to sulphur release have been elucidated with a fair degree of certainty. Logical explanations for the variations of sulphur release with temperature and with liquor solids content have been proposed. The influence of pressure has been investigated in order to gain insights into the effects of mass transfer on the sulphur-release rate. In the near future, the research will be aimed at generating the kinetic data necessary for modelling the release of sulphur in the recovery furnace. (author)

  5. Pressure Sores

    ... injury. Some chronic diseases, such as diabetes and hardening of the arteries, make it hard for pressure ... Use a mild soap and warm (not hot) water. Apply moisturizers so your skin doesn’t get ...

  6. Pressure sensor

    Mee, David K.; Ripley, Edward B.; Nienstedt, Zachary C.; Nienstedt, Alex W.; Howell, Jr., Layton N.


    Disclosed is a passive, in-situ pressure sensor. The sensor includes a sensing element having a ferromagnetic metal and a tension inducing mechanism coupled to the ferromagnetic metal. The tension inducing mechanism is operable to change a tensile stress upon the ferromagnetic metal based on a change in pressure in the sensing element. Changes in pressure are detected based on changes in the magnetic switching characteristics of the ferromagnetic metal when subjected to an alternating magnetic field caused by the change in the tensile stress. The sensing element is embeddable in a closed system for detecting pressure changes without the need for any penetrations of the system for power or data acquisition by detecting changes in the magnetic switching characteristics of the ferromagnetic metal caused by the tensile stress.

  7. High-pressure plastic scintillation detector for measuring radiogenic gases in flow systems

    Schell, W R; Yoon, S R; Tobin, M J


    Radioactive gases are emitted into the atmosphere from nuclear electric power and nuclear fuel reprocessing plants, from hospitals discarding xenon used in diagnostic medicine, as well as from nuclear weapons tests. A high-pressure plastic scintillation detector was constructed to measure atmospheric levels of such radioactive gases by detecting the beta and internal conversion (IC) electron decays. Operational tests and calibrations were made that permit integration of the flow detectors into a portable Gas Analysis, Separation and Purification system (GASP). The equipment developed can be used for measuring fission gases released from nuclear reactor sources and/or as part of monitoring equipment for enforcing the Comprehensive Test Ban Treaty. The detector is being used routinely for in-line gas separation efficiency measurements, at the elevated operational pressures used for the high-pressure swing analysis system (2070 kPa) and at flow rates of 5-15 l/min . This paper presents the design features, opera...

  8. Clinical observation of arthroscopic lateral retinacular release in the treatment of patella lateral pressure syndrome%关节镜下外侧支持带松解治疗髌骨外侧高压综合征临床疗效观察

    廖军; 孟庆才


    目的:探讨关节镜下外侧支持带松解术治疗髌骨外侧高压综合征(EL PS )的临床疗效。方法选择2009年6月-2013年8月新疆医科大学附属中医医院关节外科收治的100例髌骨外侧高压综合征患者,将其分为两组:关节镜下行外侧支持带松解术58例(ALRR组),保守治疗42例(对照组),参考Lysholm膝关节功能评分评价临床疗效。结果两组患者随访3~15个月,平均8.6个月,对照组和 ALRR组有效率分别为85.71%和982.8%;两组患者治疗后Lysholm评分均较治疗前提高,差异有统计学意义(P <00.5);两组患者治疗后Lysholm评分差异有统计学意义(P <00.5),ALRR组高于对照组。结论关节镜下外侧支持带松解术可有效地减轻髌骨外侧高压导致的髌股关节疼痛,且具备术后康复快、并发症少、膝关节功能恢复好等优势,其远期疗效有待进一步观察。%Objective To discuss the effective and clinical value of arthroscopic lateral retinaculum release treatment in excessive lateral pressure syndrome .Methods From June 2009 to August 2013 ,110 patients with patellar lateral pressure syndrome were randomly divided into lateral retinaculum under arthroscopy release (ALRR) treatment group (58 cases ,conservative treatment group (42 cases ,two groups of pa-tients with preoperative general data no statistically significant difference (P >0 0.5) ,there was no statis-tically significant difference Lysholm score before treatment (P >0 0.5) .Results Two groups of patients were followed up for 3-15 months ,an average of 8 6. months ,conservative treatment group and ALRR group effectiveness 85 7.1% ,98 2.8% respectively ;Lysholm score after treatment in both groups was im-proved ,the difference was statistically significant (P < 0 .05);Lysholm score after treatment in both groups ,the difference was statistically significant (P <0 0.5);Conclusion The lateral retinaculum

  9. Intracellular drug release nanosystems

    Fenghua Meng


    Full Text Available In order to elicit therapeutic effects, many drugs including small molecule anticancer drugs, proteins, siRNA, and DNA have to be delivered and released into the specific cellular compartments typically the cytoplasm or nucleus of target cells. Intracellular environment-responsive nanosystems that exhibit good extracellular stability while rapidly releasing drugs inside cancer cells have been actively pursued for effective cancer therapy. Here, we highlight novel designs of smart nanosystems that release drugs in response to an intracellular biological signal of cancer cells such as acidic pH in endo/lysosomal compartments, enzymes in lysosomes, and redox potential in cytoplasm and the cell nucleus.

  10. Release Behaviour of Shock Loaded LY12 Aluminium Alloy

    YAN Min; DAI Lan-Hong; SHEN Le-Tian


    @@ By making use of a light gas gun, a specially designed target is impacted by the LY12 flyer, and the pressure is taken in the range of 0.6-3 GPa. Based on the stress profiles measured in the buffer materials by manganese gauges, the Hugoniot curve and release curves of LY12 aluminium alloy are obtained. Meanwhile, the release curves from different initial shocked states are described in both the pressure-particle velocity plane and the pressure-specific volume plane.

  11. 高密度澄清池一内压式超滤组合净水工艺的试验%Water Purification Treatment Combined with High-Density Clarifier and Internal Pressure Type Uitrafiltration Membrane Technology

    鲁剑; 徐国勋


    试验采用高密度澄清池—内压式超滤组合工艺,以模拟微污染地表水为处理对象,研究了组合工艺对浊度、CODmn、UV254、NH3-N等污染物质的去除效果,探讨了反冲洗的操作条件.研究表明,在最佳运行条件下,组合工艺对浊度、CODMn、UV254和NH3-N的平均去除率分别为99.85%、43.23%、40.85%和63.72%,系统保持平稳运行;当膜通量降低到初始通量的70%时,组合工艺的工作周期比单独超滤工艺过滤持续时间延长了大约4倍左右;当要达到同样的反洗效果时,增加反洗持续时间比缩短反洗周期更有效.%The experiment used internal pressure type ultrafiltration membrane (UF), a high-density clarifier, to treat micro-polluted surface water. The removal effects of turbidity, CODMn, UV254, NH3-N were studied. The operating conditions of back washing was discussed. Results show that, in the best condition, the average removal rates of turbidity, COD, UV254, and NH3-N were 99.85 %, 43.23 %, 40.85 % and 63.72 % respectively, the system worked smoothly. As the membrane flux decreased to 70 % of the initial value, the working time of the high-density clarifier/UF combined unit is 4 times longer than that of direct filtration. At the same flux recovery, increasing the backwashing duration time was proved to be more effective than shortening backwashing interval.

  12. Miniature Release Mechanism Project

    National Aeronautics and Space Administration — The objective is to design, build and functionally test a miniature release mechanism for CubeSats and other small satellites. The WFF 6U satellite structure will be...

  13. Comparative validation of the growth hormone-releasing hormone and arginine test for the diagnosis of adult growth hormone deficiency using a growth hormone assay conforming to recent international recommendations.

    Chanson, Philippe; Cailleux-Bounacer, Anne; Kuhn, Jean-Marc; Weryha, Georges; Chabre, Olivier; Borson-Chazot, Françoise; Dubois, Séverine; Vincent-Dejean, Caroline; Brue, Thierry; Fedou, Christine; Bresson, Jean-Louis; Demolis, Pierre; Souberbielle, Jean-Claude


    The GHRH plus arginine (GHRH+Arg) test is a promising alternative to the insulin tolerance test (ITT) for diagnosis of adult GH deficiency (AGHD). The objectives of the study were to validate the GHRH+Arg test for diagnosis of AGHD, using the ITT as comparator and a GH assay calibrated according to recent international recommendations, and to study the repeatability and tolerance of both tests. This was a multicenter, randomized, open-label, phase III study. The study was conducted at 10 French university hospitals. Sixty-nine subjects (38 and 15 with high and low probability of GH deficiency, respectively, and 16 healthy controls) were randomized: 35 to the GHRH+Arg-GHRH+Arg-ITT test sequence and 34 to the ITT-ITT-GHRH+Arg test sequence. Each subject underwent three tests of GH secretion separated by 24 h or more. The primary variable used for response assessments was serum peak GH response. Test results were compared with the final AGHD diagnosis. Peak GH responses in the two tests were strongly correlated. A cutoff value of 7.89 microg/liter for GHRH+Arg corresponding to 3 microg/liter for ITT was calculated. The cutoff value leading to 95% specificity with the GHRH+Arg test was measured at about 3.67 microg/liter (sensitivity 79.0%). Intermethod agreement and repeatability were high. Both tests were well tolerated. A preference for the GHRH+Arg test was expressed by 74% of subjects. The GHRH+Arg test demonstrated good accuracy and repeatability, was at least as sensitive as the ITT, and was associated with better subject acceptability. The GHRH+Arg test represents a good alternative to the ITT for the diagnosis of AGHD.

  14. 奶茶杯内膜中增塑剂含量的检测分析%Determination of the Three Plasticizer Release into Some Fat-soluble Analog Solution from Tea Milk-Tea Cup of Internal Film



    The high-performance liquid chromatographic method was developed for the determination of 3 phthalic acid esters (PAEs) in Milk-Tea cup of internal film,including di-butyl phthalate (DBP),di-(2-ethylhexyl) phthalate (DEHP)and dioctyl phthalate (DOP) 3 kinds of plasticizers to lipophilic simulations of liquid ( milk, vegetable oil, isooctane ) .The results showed that, tea cups lining materials through lipid soluble analog fluid after soaking with DEP and DBP detection, DOP not detected, DBP detectable quantities in the EU directive 2007/19/EC in a prescribed range, DEP detection was much greater than that of British farming fishing Ministry of food provisions daily tolerance.%采用高效液相色谱法测定奶茶杯内膜材料中的邻苯二甲酸(2-乙基己基)酯(DEHP)、邻苯二甲酸二丁酯(DBP)、邻苯二甲酸二辛脂(DOP)3种增塑剂向脂溶性模拟液(牛奶、植物油、异辛烷)中的迁移溶出量。结果表明,奶茶杯内膜材料经过脂溶性模拟液浸泡后有DEHP和DBP的检出,DOP未检出,DBP检出量在欧盟指令2007/19/EC的规定范围内,DEHP检出量远大于英国农渔食品部规定的的每日耐受量。

  15. Thermodynamical effects during carbon dioxide release

    Singh, A. K.; Böttcher, N.; Görke, U.-J.; Kolditz, O.


    Pruess [1] investigated the risk of carbon dioxide leakage from shallow storage sites by modeling scenarios. Such a fluid release is associated with mechanical work performed by formation fluid against expansion without taking heat from ambient environment. Understanding of heat related to mechanical work is essential to predict the temperature at the leak. According to the first law of thermodynamics, internal energy of working fluid decreases with an amount which is equivalent to this work hence, working fluid lost its own heat. Such kind of heat loss depends strongly on whether the expansion process is adiabatic or isothermal. Isothermal expansion allows the working fluid to interact thermally with the solid matrix. Adiabatic expansion is an isenthalpic process that takes heat from the working fluid and the ambient environment remains unchanged. This work is part of the CLEAN research project [6]. In this study, thermodynamic effects of mechanical work during eventual carbon dioxide leakage are investigated numerically. In particular, we are interested to detect the temperature at leakage scenarios and its deviation with different thermodynamic processes. Finite element simulation is conducted with a two-dimensional rectangular geometry representing a shallow storage site which bottom was located at -300m below the land surface. A fully saturated porous medium is assumed where the pore space is filled completely with carbon dioxide. Carbon dioxide accumulated in the secondary trap at 30 Bar and 24 °C is allowed to leak from top right point of rectangle with atmospheric pressure. With (i) adiabatic and (ii) isothermal compressibility factors, temperature around leakage area has been calculated which show a significant difference. With some simplification, this study detects leak temperature which is very close with [1]. Temporal evaluation at the leaky area shows that the working fluid temperature can be reduced to -20 °C when the leakage scenario is performed

  16. Electrosprayed nanoparticle delivery system for controlled release

    Eltayeb, Megdi, E-mail: [Department of Biomedical Engineering, Sudan University of Science and Technology, PO Box 407, Khartoum (Sudan); Stride, Eleanor, E-mail: [Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Headington OX3 7DQ (United Kingdom); Edirisinghe, Mohan, E-mail: [Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE (United Kingdom); Harker, Anthony, E-mail: [London Centre for Nanotechnology, Gordon Street, London WC1H 0AH (United Kingdom); Department of Physics & Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)


    This study utilises an electrohydrodynamic technique to prepare core-shell lipid nanoparticles with a tunable size and high active ingredient loading capacity, encapsulation efficiency and controlled release. Using stearic acid and ethylvanillin as model shell and active ingredients respectively, we identify the processing conditions and ratios of lipid:ethylvanillin required to form nanoparticles. Nanoparticles with a mean size ranging from 60 to 70 nm at the rate of 1.37 × 10{sup 9} nanoparticles per minute were prepared with different lipid:ethylvanillin ratios. The polydispersity index was ≈ 21% and the encapsulation efficiency ≈ 70%. It was found that the rate of ethylvanillin release was a function of the nanoparticle size, and lipid:ethylvanillin ratio. The internal structure of the lipid nanoparticles was studied by transmission electron microscopy which confirmed that the ethylvanillin was encapsulated within a stearic acid shell. Fourier transform infrared spectroscopy analysis indicated that the ethylvanillin had not been affected. Extensive analysis of the release of ethylvanillin was performed using several existing models and a new diffusive release model incorporating a tanh function. The results were consistent with a core-shell structure. - Highlights: • Electrohydrodynamic spraying is used to produce lipid-coated nanoparticles. • A new model is proposed for the release rates of active components from nanoparticles. • The technique has potential applications in food science and medicine. • Electrohydrodynamic processing controlled release lipid nanoparticles.

  17. Internal and International Corruption

    Dr.Sc. Mario Antinucci


    Full Text Available This subject, whence the name of this paper originates from, must be addressed with courage and intellectual integrity by all of us, the different parts of the civil society, the public institutions, the entrepreneurs and the legal professionals, the youth and the new generations. All the public policies of the European governments share the belief of a direct correlation between the criminal density connected to corruption of States political and economic protagonists and the lack of availability of investments on young talents, new generations, both in the entrepreneurial and in the professional fields. In most Member States, anticorruption policies have gained an increased prominence in government agendas and the financial crisis has drawn attention to the integrity and accountability of policy-makers. Most Member States that are currently in serious financial difficulties have acknowledged the seriousness of issues related to corruption and have created (or are planning anticorruption programs in order to deal with the risks deriving from this issue and with the diversion of public funds. In some Member States, the economic adjustment programs provide for explicit obligations related to anti-corruption policies. Even when not formally connected to adjustment programs, anticorruption policies complement the adjustment measures, especially in those countries in which corruption is a serious issue.  During the European Semester of economic policy coordination, recommendations for efficiently fighting corruption have been laid out; Among the most vulnerable sectors, urban development and building projects are certainly very exposed to corruption risks and to infiltration of internal and transnational organized crime.

  18. Building an Efficient Model for Afterburn Energy Release

    Alves, S; Kuhl, A; Najjar, F; Tringe, J; McMichael, L; Glascoe, L


    Many explosives will release additional energy after detonation as the detonation products mix with the ambient environment. This additional energy release, referred to as afterburn, is due to combustion of undetonated fuel with ambient oxygen. While the detonation energy release occurs on a time scale of microseconds, the afterburn energy release occurs on a time scale of milliseconds with a potentially varying energy release rate depending upon the local temperature and pressure. This afterburn energy release is not accounted for in typical equations of state, such as the Jones-Wilkins-Lee (JWL) model, used for modeling the detonation of explosives. Here we construct a straightforward and efficient approach, based on experiments and theory, to account for this additional energy release in a way that is tractable for large finite element fluid-structure problems. Barometric calorimeter experiments have been executed in both nitrogen and air environments to investigate the characteristics of afterburn for C-4 and other materials. These tests, which provide pressure time histories, along with theoretical and analytical solutions provide an engineering basis for modeling afterburn with numerical hydrocodes. It is toward this end that we have constructed a modified JWL equation of state to account for afterburn effects on the response of structures to blast. The modified equation of state includes a two phase afterburn energy release to represent variations in the energy release rate and an afterburn energy cutoff to account for partial reaction of the undetonated fuel.

  19. Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children.

    Cicchetti, Dante; Rogosch, Fred A


    Genetic moderation of the effects of child maltreatment on depression and internalizing symptoms was investigated in a sample of low-income maltreated and nonmaltreated African American children (N = 1,096). Lifetime child maltreatment experiences were independently coded from Child Protective Services records and maternal report. Child depression and internalizing problems were assessed in the context of a summer research camp by self-report on the Children's Depression Inventory and adult counselor report on the Teacher Report Form. DNA was obtained from buccal cell or saliva samples and genotyped for polymorphisms of the following genes: serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter, and corticotropin releasing hormone receptor 1. Analyses of covariance with age and gender as covariates were conducted, with maltreatment status and respective polymorphism as main effects and their Gene × Environment (G × E) interactions. Maltreatment consistently was associated with higher Children's Depression Inventory and Teacher Report Form symptoms. The results for child self-report symptoms indicated a G × E interaction for BDNF and maltreatment. In addition, BDNF and triallelic 5-HTTLPR interacted with child maltreatment in a G × G × E interaction. Analyses for counselor report of child anxiety/depression symptoms on the Teacher Report Form indicated moderation of child maltreatment effects by triallelic 5-HTTLPR. These effects were elaborated based on variation in developmental timing of maltreatment experiences. Norepinephrine transporter was found to further moderate the G × E interaction of 5-HTTLPR and maltreatment status, revealing a G × G × E interaction. This G × G × E was extended by consideration of variation in maltreatment subtype experiences. Finally, G × G × E effects were observed for the co-action of BDNF and the corticotropin releasing hormone receptor 1

  20. International arbejdsdeling

    Henten, Anders


    Article dealing with the implications of informátion and communication technologies on the international division of labour.......Article dealing with the implications of informátion and communication technologies on the international division of labour....

  1. Internal Bleeding

    ... in Paralyzed Monkeys Additional Content Medical News Internal Bleeding By Amy H. Kaji, MD, PhD, Associate Professor, ... Emergency First Aid Priorities Cardiac Arrest Choking Internal Bleeding Wounds Soft-Tissue Injuries Severed or Constricted Limbs ...

  2. Alterations in Brain Monoamine Neurotransmitter Release at High Pressure


    Services Division F 02-295-2188 ISD/ADMIN/hNXRI )D FORM 1473,84 MAR 83 APR edition may oe used until exnausted. SECURITY CLASIFICATION OF TWIS PAGE of the synaptosomal preparation con- taining 3.0 3.5 mg ml protein were incubated for Is mm Of [3H]serotonin from synaptosome fractions iso- 370...Brauer R"’. Beaser RW. Sheehan ME (1978) Role of mono- S~napsin I ( protein I1). a nerse terminal-specific phospho- amnine neurotransmnitters in the

  3. Pressure Suppresses Serotonin Release by Guinea Pig Striatal Synaptosomes


    cuerpo estriado-de conejillos de Indias.-Undersea Biorned Res 19,98; 15(2):69-77. La exposici6n a presiones altas produce cambios neurol6gicos en...sistemna serotonin~rgico en estos sintortias, nuestro’itr~s residi6 en el estudic de Ia Iiberaci6n de serotonina a presiones altas. SC empleo

  4. Oxygen (Average seabed consumption) data collected using pressure gauge from the Northwest Atlantic Ocean in part of the International Decade of Ocean Exploration / Mid-Ocean Dynamics Experiment from 18 March 1973 to 07 September 1973 (NODC Accession 7700231)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oxygen (average seabed consumption) data were collected using pressure gauge from March 11, 1973 to July 1, 1973. Data were submitted by Scripps Institution of...

  5. Iliopsoas Tendon Reformation after Psoas Tendon Release

    K. Garala


    Full Text Available Internal snapping hip syndrome, or psoas tendonitis, is a recognised cause of nonarthritic hip pain. The majority of patients are treated conservatively; however, occasionally patients require surgical intervention. The two surgical options for iliopsoas tendinopathy are step lengthening of the iliopsoas tendon or releasing the tendon at the lesser trochanter. Although unusual, refractory snapping usually occurs soon after tenotomy. We report a case of a 47-year-old active female with internal snapping and pain following an open psoas tenotomy. Postoperatively she was symptom free for 13 years. An MRI arthrogram revealed reformation of a pseudo iliopsoas tendon reinserting into the lesser trochanter. The pain and snapping resolved after repeat iliopsoas tendon release. Reformation of tendons is an uncommon sequela of tenotomies. However the lack of long-term studies makes it difficult to calculate prevalence rates. Tendon reformation should be included in the differential diagnosis of failed tenotomy procedures after a period of symptom relief.

  6. Iliopsoas tendon reformation after psoas tendon release.

    Garala, K; Power, R A


    Internal snapping hip syndrome, or psoas tendonitis, is a recognised cause of nonarthritic hip pain. The majority of patients are treated conservatively; however, occasionally patients require surgical intervention. The two surgical options for iliopsoas tendinopathy are step lengthening of the iliopsoas tendon or releasing the tendon at the lesser trochanter. Although unusual, refractory snapping usually occurs soon after tenotomy. We report a case of a 47-year-old active female with internal snapping and pain following an open psoas tenotomy. Postoperatively she was symptom free for 13 years. An MRI arthrogram revealed reformation of a pseudo iliopsoas tendon reinserting into the lesser trochanter. The pain and snapping resolved after repeat iliopsoas tendon release. Reformation of tendons is an uncommon sequela of tenotomies. However the lack of long-term studies makes it difficult to calculate prevalence rates. Tendon reformation should be included in the differential diagnosis of failed tenotomy procedures after a period of symptom relief.

  7. A fluoride release-adsorption-release system applied to fluoride-releasing restorative materials.

    Suljak, J P; Hatibovic-Kofman, S


    This investigation compared the initial fluoride release and release following refluoridation of three resin-modified glass-ionomer cements (Photac-Fil Applicap, Vitremer, and Fuji II LC) and a new polyacid-modified resin composite material (Dyract). After daily flouride release was measured for 8 days, specimens were refluoridated in 1,000-ppm solutions of fluoride ion for 10 minutes and fluoride release was measured for 5 days. Two further 5-day refluoridation-release periods were carried out. All materials released fluoride initially. Photac released the most; Dyract released the least. Initial release was greatest over the first few days. All materials released significantly more fluoride for 24 to 48 hours after refluoridation. Less fluoride was released with each successive refluoridation for the three glass-ionomer cements. The release from the Dyract compomer remained at a comparatively constant and significantly lower level following each refluoridation.

  8. RAVEN Beta Release

    Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alfonsi, Andrea [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cogliati, Joshua Joseph [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mandelli, Diego [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinoshita, Robert Arthur [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wang, Congjian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Maljovec, Daniel Patrick [Idaho National Lab. (INL), Idaho Falls, ID (United States); Talbot, Paul William [Idaho National Lab. (INL), Idaho Falls, ID (United States)


    This documents the release of the Risk Analysis Virtual Environment (RAVEN) code. A description of the RAVEN code is provided, and discussion of the release process for the M2LW-16IN0704045 milestone. The RAVEN code is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. RAVEN is capable of investigating the system response as well as the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. RAVEN has now increased in maturity enough for the Beta 1.0 release.

  9. Controlled-release microchips.

    Sharma, Sadhana; Nijdam, A Jasper; Sinha, Piyush M; Walczak, Robbie J; Liu, Xuewu; Cheng, Mark M-C; Ferrari, Mauro


    Efficient drug delivery remains an important challenge in medicine: continuous release of therapeutic agents over extended time periods in accordance with a predetermined temporal profile; local delivery at a constant rate to the tumour microenvironment to overcome much of the systemic toxicity and to improve antitumour efficacy; improved ease of administration, and increasing patient compliance required are some of the unmet needs of the present drug delivery technology. Microfabrication technology has enabled the development of novel controlled-release microchips with capabilities not present in the current treatment modalities. In this review, the current status and future prospects of different types of controlled-release microchips are summarised and analysed with reference to microneedle-based microchips, as well as providing an in-depth focus on microreservoir-based and nanoporous microchips.

  10. Evaluation of the internal pressure in UO{sub 2} and UO{sub 2}-Gd{sub 2}O{sub 3} rods of fuel assemblies 10 x 10 with the FEMAXI-Vi code; Evaluacion de la presion interna en barras de UO{sub 2} y UO{sub 2}-Gd{sub 2}O{sub 3} de ensambles combustibles 10 x 10 con el codigo FEMAXI-VI

    Hernandez L, H.; Lucatero, M. A., E-mail: [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)


    Inside the acceptable criterions of fuel licensing are some that should be fulfilled in relation to the internal pressure of the fuel rods. These criterions are related with the loss of mechanical integrity due to the load excess in the pressure inside the jacket, as well as by the pressure that exercises the pellet on the jacket at the time of suffering the swelling by irradiation. This work shows the calculation of the increment of the internal pressure of the fuel rods caused by the swelling contribution of the pellets and by the accumulation of the fission gases inside the hole, pellet-jacket, in function of the burned for values of the lineal heat generation reason (LHGR) mean of fuel rods in arrangements 10 x 10. (author)

  11. Polysaccharides As Safer Release Systems For Agrochemicals

    Campos E.V.R.; de Oliveira J.L.; Fraceto L.F.; Singh B


    International audience; Agrochemicals are used to improve the production of crops. Conventional formulations of agrochemicals can contaminate the environment, in particular in the case of intensive cropping. Hence, there is a need for controlled-release formulations of agrochemicals such as polysaccharides to reduce pollution and health hazards. Natural polysaccharides are hydrophilic, biodegradable polymers. This article reviews the use of polysaccharides in the form of micro- and nanopartic...

  12. Organization and management of ATLAS software releases

    S. Albrand; J. Collot; Fulachier, J.; Lambert, F.; Arnault, C.; Garonne, V.; Schaffer, A.; Nzuobontane, E.; Sherwood, P.; Simmons, B.; George, S.; Rybkine, G.; Holloway, R; Lloyd, S; E. Obreshkov, .


    International audience; ATLAS is one of the largest collaborations ever undertaken in the physical sciences. This paper explains how the software infrastructure is organized to manage collaborative code development by around 300 developers with varying degrees of expertise, situated in 30 different countries. We will describe how the succeeding releases of the software are built, validated and subsequently deployed to remote sites. Several software management tools have been used, the majorit...

  13. A Responsive Battery with Controlled Energy Release.

    Wang, Xiaopeng; Gao, Jian; Cheng, Zhihua; Chen, Nan; Qu, Liangti


    A new type of responsive battery with the fascinating feature of pressure perceptibility has been developed, which can spontaneously, timely and reliably control the power outputs (e.g., current and voltage) in response to pressure changes. The device design is based on the structure of the Zn-air battery, in which graphene-coated sponge serves as pressure-sensitive air cathode that endows the whole system with the capability of self-controlled energy release. The responsive batteries exhibit superior battery performance with high open-circuit voltage (1.3 V), and competitive areal capacity of 1.25 mAh cm(-2) . This work presents an important move towards next-generation intelligent energy storage devices with energy management function. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Pressure transducer

    Anderson, Thomas T.; Roop, Conard J.; Schmidt, Kenneth J.; Gunchin, Elmer R.


    A pressure transducer suitable for use in high temperature environments includes two pairs of induction coils, each pair being bifilarly wound together, and each pair of coils connected as opposite arms of a four arm circuit; an electrically conductive target moveably positioned between the coil pairs and connected to a diaphragm such that deflection of the diaphragm causes axial movement of the target and an unbalance in the bridge output.

  15. Regulation of atriopeptin release from the isolated rat heart

    Currie, M.G.; Newman, W.H.


    Recent studies have demonstrated that the mammalian atria possess an endocrine function which appears to play a role in the regulation of systemic arterial pressure, fluid balance, and electrolyte homeostasis. They have begun to study the regulation of atriopeptin (atrial natriuretic factor) release into the coronary effluent of the isolated perfused rat heart. Characterization by high pressure liquid chromatography of the form of the hormone released indicates that the predominant form is the active low MW circulating hormone not the pro-hormone. The release of immunoreactive atriopeptin (iAP) was stimulated by infusion of norepinephrine (1 or epinephrine (1 3.0 and 2.6-fold, respectively. The ..beta..-adrenergic agonist isoproterenol and the ..cap alpha..-2 adrenergic agonist BHT-920 lacked effects on iAP release. On the other hand, the ..cap alpha..-1 adrenergic agonist phenylephrine caused a dose-dependent increase in release of iAP. Release of iAP stimulated by phenylephrine was inhibited by the ..cap alpha.. antagonist phentolamine. Further, iAP release was stimulated 4.2-fold by phorbol ester (1 but was not affected by 4-..beta.. phorbol (1 From these collective data they conclude that the release of atriopeptin is stimulated by ..cap alpha..-1 receptor activation and that protein kinase C participates in the regulation of secretion. The data suggests that the sympathetic nervous system may play a physiologic role in the regulation of atriopeptin secretion.

  16. Release of OLe peanut

    OLe is a high oleic Spanish-type peanut that has excellent yield and enhanced Sclerotinia blight and pod rot resistance when compared to other high oleic Spanish cultivars. The purpose for releasing OLe is to provide peanut producers with a true Spanish peanut that is high oleic and has enhanced yi...

  17. Border cell release

    Mravec, Jozef


    Plant border cells are specialised cells derived from the root cap with roles in the biomechanics of root growth and in forming a barrier against pathogens. The mechanism of highly localised cell separation which is essential for their release to the environment is little understood. Here I present...

  18. Beam Loss Diagnostics Based on Pressure Measurements

    Weinrich, U


    The GSI is operating a heavy ion synchrotron, which is currently undergoing an upgrade towards higher beam intensities. It was discovered that beam losses induce a significant pressure increase in the vacuum system. In order to detect the time constants of the pressure increase and decrease, fast total pressure measurements were put into operation. With the recently installed partial pressure diagnostics it is also possible to follow up which types of molecules are released. The presentation will focus on the different techniques applied as well as on some measurement results. The potential and difficulties of this diagnostic tool will also be discussed.

  19. Healthy Travel for International Adoptions


    The number of international adoptions, many from developing countries, has doubled in the last 10 years. This podcast discusses ways adoptive families can protect their own health and the health of their new children.  Created: 10/22/2007 by National Center for the Prevention, Detection and Control of Infectious Diseases (NCPDCID).   Date Released: 10/24/2007.

  20. Beijing: Next International Financial Hub?

    Li Zhen


    @@ Beijing's new financial dream On May 5,the Beijing Municipal Government released a notice regarding its plans to spur the financial industry,vowing to put forth a strong effort to become the national financial decision-making center,financial management center and financial information and services center,and formally announcing its ambitious aspiration to become a financial hub with international influence.

  1. Blood pressure measurement

    Diastolic blood pressure; Systolic blood pressure; Blood pressure reading; Measuring blood pressure ... or your health care provider will wrap the blood pressure cuff snugly around your upper arm. The lower ...

  2. Controlled Release of the Indomethacin Microencapsulation Based on Layer-by-layer Assembly by Polyelectrolyte Multilayers

    CHEN You-fang; LIN Xian-fu


    Indomethacin has been encapsulated with polyelectrolyte multilayers for controlled release. Gelatin and alginate were alternatively deposited on indomethacin microcrystals. The released amount of indomethacin from coated microcrystals in pH6. 8phosphate buffer solution (PBS) was measured with a UV spectrophometer. The polyelectrolyte multilayer capsule thickness was proved to control the release rate. The effects of osmotic pressure existed during the release process of indomethacin from microcapsules coated by (gelatin/alginate) 4.

  3. Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism.

    zur Mühlen, A; Schwarz, C; Mehnert, W


    Solid lipid nanoparticles (SLN) are particulate systems for parenteral drug administration with mean particle diameters ranging from 50 up to 1000 nm. The model drugs tetracaine, etomidate and prednisolone were incorporated (1, 5 and 10%) to study the drug load, effect of drug incorporation on the structure of the lipid matrix and the release profiles and mechanism. SLN were produced by high pressure homogenization of aqueous surfactant solutions containing the drug-loaded lipids in the melted or in the solid state (500/1500 bar, 3/10 cycles). In case of tetracaine and etomidate, high drug loadings up to 10% could be achieved when using Compritol 888 ATO and Dynasan 112 as matrix material. The melting behavior of the drug loaded particles revealed that little or no interactions between drug and lipid occurred. A burst drug release (100% release < 1 min) was observed with tetracaine and etomidate SLN, which was attributed to the large surface area of the nanoparticles and drug enrichment in the outer shell of the particles. In contrast, prednisolone loaded SLN showed a distinctly prolonged release over a monitored period of 5 weeks. Depending on the chemical nature of the lipid matrix, 83.8 and 37.1% drug were released (cholesterol and compritol, respectively). These results demonstrate the principle suitability of SLN as a prolonged release formulation for lipophilic drugs.

  4. Clinical study on the effects of lateral retinaculum release with small knife needle in the treatment of excessive lateral pressure syndrome of patellofemoral joint%小针刀松解髌股外侧支持带治疗髌股外侧高压综合征的临床研究

    刘劲松; 张道平


    Objective:To explore the clinical curative effects of lateral retinaculum release with small knife needle in the treatment of excessive lateral pressure syndrome of patellofemoral joint. Methods :60 patients with excessive lateral pressure syndrome of patellofemoral joint were randomly divided into experimental group and control group, 30 cases in each group. Patients in the experimental group were administrated with lateral retinaculum release with small knife needle,while the others in the control group were administrated with triamcinolone acetonide injection into the knee joint cavity. The curative effects of the patients were evaluated according to the improved Lysholm scoring standards, visual analogue scales(VAS) and Kujala scoring system. Results:①There was no statistical difference in VAS of the patients between the 2 groups before the treatment(t =2. 121 ,P =0.061 ). At the final follow - up time,VAS of patients in the experimental group were lower than those of patients in the control group, while the score differences before and after the treatment of experimental group were higher than those of control group( t = - 10.589, P = 0.000; t = 49. 410, P = 0. 000). ②There was no statistical difference in Kujala scores of the patients between the 2 groups before the treatment( t = -0. 707 ,P = 0. 488). At the final follow -up time, Kujala scores and score differences before and after the treatment in the experimental group were all higher than those in the control groul ( t = 4. 1 89, P =0.000; t = 6.608, P = 0.001 ). ③The curative effects of the experimental group were better than those of the control group according to the improved Lysholm scoring standards( u = 1. 960 ,P = 0.028 ). Conclusion: The therapy of lateral retinaculum release with small knife needle is effective in the treatment of excessive lateral pressure syndrome of patellofemoral joint.%目的:探讨小针刀松解髌股外侧支持带治疗髌股外侧高压综合征的临床

  5. Comparison of the direct burst pressure and the ring tensile test methods for mechanical characterization of tissue-engineered vascular substitutes.

    Laterreur, Véronique; Ruel, Jean; Auger, François A; Vallières, Karine; Tremblay, Catherine; Lacroix, Dan; Tondreau, Maxime; Bourget, Jean-Michel; Germain, Lucie


    Tissue engineering provides a promising alternative for small diameter vascular grafts, especially with the self-assembly method. It is crucial that these grafts possess mechanical properties that allow them to withstand physiological flow and pressure without being damaged. Therefore, an accurate assessment of their mechanical properties, especially the burst pressure, is essential prior to clinical release. In this study, the burst pressure of self-assembled tissue-engineered vascular substitutes was first measured by the direct method, which consists in pressurizing the construct with fluid until tissue failure. It was then compared to the burst pressure estimated by Laplace׳s law using data from a ring tensile test. The major advantage of this last method is that it requires a significantly smaller tissue sample. However, it has been reported as overestimating the burst pressure compared to a direct measurement. In the present report, it was found that an accurate estimation of the burst pressure may be obtained from a ring tensile test when failure internal diameter is used as the diameter parameter in Laplace׳s law. Overestimation occurs with the method previously reported, i.e. when the unloaded internal diameter is used for calculations. The estimation of other mechanical properties was also investigated. It was demonstrated that data from a ring tensile test provide an accurate estimate of the failure strain and the stiffness of the constructs when compared to measurements with the direct method. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Shoot water relations of mature black spruce families displaying a genotype × environment interaction in growth rate. III. Diurnal patterns as influenced by vapor pressure deficit and internal water status

    John E. Major; Kurt H. Johnsen


    Pressure­volume curves were constructed and shoot water potentials measured for +20-year-old black spruce (Picea mariana (Mill.) BSP) trees from four full-sib families growing on a moist site and a dry site at the Petawawa Research Forest, Ontario, to determine whether differences in diurnal water relations traits were related to productivity. To...

  7. Erratum: Correction to Table 3, in: Equivalent threshold sound pressure levels (ETSPL) for Sennheiser HDA 280 supra-aural audiometric earphones in the frequency range 125 Hz to 8000 Hz (International Journal of Audiology (2009) 48 (271-276))

    Poulsen, Torben


    The main results in Poulsen & Oakley (2009) are given as the equivalent threshold sound pressure level, ETSPL, measured in an acoustic coupler specifi ed in IEC 60318-3. These results are all correct. The ETSPL values for the ear simulator specifi ed in IEC 60318-1 were calculated from acoustic...

  8. 75 FR 8114 - Pressure Sensitive Plastic Tape From Italy


    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Pressure Sensitive Plastic Tape From Italy AGENCY: United States International Trade Commission. ACTION: Revised schedule for the subject review. DATES: Effective Date: February 16, 2010. FOR...

  9. [Role of internal mediators in surgical stress].

    Endo, Shigeatsu; Sato, Nobuhiro


    In surgical stress, internal mediators include cytokines released locally as well as into the circulation; activation of neutrophils, monocytes, macrophages, endothelial cells, platelets and other cells; activation of plasma protein cascade systems such the complement, coagulation, fibrinolytic and contact systems the release of tissue-damaging proteinases; the formation of lipid mediators such as eicosanoids and platelet-activating factor; and the generation of oxygen and nitrogen radicals. In addition, during host defense rections, a number of agents are released that blunt the inflammatory response, such as anti-inflamatory cytokines, soluble cytokine receptors, acute-phase proteins including proteinase inhibitors and stress hormones. In this paper, we explain such internal mediators.

  10. International skatteret

    Winther-Sørensen, Niels; Wittendorff, Jens


    De seneste 6 måneders udvikling indenfor international skatteret beskrives. NW-S har skrevet artiklens afsnit om udvalgte afgørelser og om EU-skatteret.......De seneste 6 måneders udvikling indenfor international skatteret beskrives. NW-S har skrevet artiklens afsnit om udvalgte afgørelser og om EU-skatteret....

  11. International indsats

    Sachs, Therese

    En analyse af Beredskabsstyrelsens internationale engagement og muligheder for international indsats fremover. Forslag til struktur logistisk og materielt samt til udvikling af personel-kompetencer......En analyse af Beredskabsstyrelsens internationale engagement og muligheder for international indsats fremover. Forslag til struktur logistisk og materielt samt til udvikling af personel-kompetencer...

  12. International Curriculums.

    Neal, Larry L.

    This workshop presentation on international curriculums in the field of parks, recreation, leisure, cultural services, and travel/tourism comments that the literature is replete with articles addressing what the field is about, but not about curriculum issues, models, and structure. It reports an international survey of 12 college educators…

  13. Combustion dynamics of low vapour pressure nanofuel droplets

    Pandey, Khushboo; Chattopadhyay, Kamanio; Basu, Saptarshi


    Multiscale combustion dynamics, shape oscillations, secondary atomization, and precipitate formation have been elucidated for low vapour pressure nanofuel [n-dodecane seeded with alumina nanoparticles (NPs)] droplets. Dilute nanoparticle loading rates (0.1%-1%) have been considered. Contrary to our previous studies of ethanol-water blend (high vapour pressure fuel), pure dodecane droplets do not exhibit internal boiling after ignition. However, variation in surface tension due to temperature causes shape deformations for pure dodecane droplets. In the case of nanofuels, intense heat release from the enveloping flame leads to the formation of micron-size aggregates (of alumina NPS) which serve as nucleation sites promoting heterogeneous boiling. Three boiling regimes (A, B, and C) have been identified with varying bubble dynamics. We have deciphered key mechanisms responsible for the growth, transport, and rupture of the bubbles. Bubble rupture causes ejections of liquid droplets termed as secondary atomization. Ejection of small bubbles (mode 1) resembles the classical vapour bubble collapse mechanism near a flat free surface. However, large bubbles induce severe shape deformations as well as bulk oscillations. Rupture of large bubbles results in high speed liquid jet formation which undergoes Rayleigh-Plateau tip break-up. Both modes contribute towards direct fuel transfer from the droplet surface to flame envelope bypassing diffusion limitations. Combustion lifetime of nanofuel droplets consequently has two stages: stage I (where bubble dynamics are dominant) and stage II (formation of gelatinous mass due to continuous fuel depletion; NP agglomeration). In the present work, variation of flame dynamics and spatio-temporal heat release (HR) have been analysed using high speed OH* chemiluminescence imaging. Fluctuations in droplet shape and flame heat release are found to be well correlated. Droplet flame is bifurcated in two zones (I and II). Flame response is

  14. International Specialization

    Kleindienst, Ingo; Geisler Asmussen, Christian; Hutzschenreuter, Thomas;


    Whether and how international diversification and cross-border arbitrage affects firm performance remains one of the major unresolved research questions in the strategy and international business literatures. We propose that knowing how much a firm has internationally diversified tells us very...... little about performance implications, if we do not know, and do not ask, how the firm has diversified. Therefore, building on the two broad arguments of operating flexibility and location-specific commitment, we develop a theoretical framework that focuses on the extent to which a firm's international...... arbitrage strategy is characterized by specialization versus replication and argue that these different strategies may have differential impact on profitability and risk reduction. Developing a sophisticated measure of international specialization and using a unique panel data set of 92 German MNEs to test...

  15. International Specialization

    Kleindienst, Ingo; Geisler Asmussen, Christian; Hutzschenreuter, Thomas


    Whether and how international diversification and cross-border arbitrage affects firm performance remains one of the major unresolved research questions in the strategy and international business literatures. We propose that knowing how much a firm has internationally diversified tells us very...... little about performance implications, if we do not know, and do not ask, how the firm has diversified. Therefore, building on the two broad arguments of operating flexibility and location-specific commitment, we develop a theoretical framework that focuses on the extent to which a firm's international...... arbitrage strategy is characterized by specialization versus replication and argue that these different strategies may have differential impact on profitability and risk reduction. Developing a sophisticated measure of international specialization and using a unique panel data set of 92 German MNEs to test...

  16. International Relations:

    This is the textbook for the Open University module International Relations: Continuity and Change in Global Politics. Instead of leading with a succession of theoretical 'isms', the module structures its presentation of the subject around six teaching ‘blocks’, each of which explores a dilemma......: Flat or uneven? Change and transformation in the international system • Block 3: Just or unjust? Intervention and inequality in the international system • Block 4: Top-down or bottom-up? Governance in the international system • Block 5: Secure or insecure? Pursuing security in the international system...... • Block 6: Continuity or change in global politics? Each block introduces new IR theories through discussions of the substantive dilemmas and adds in a layered way levels of analysis and conceptual complexity....

  17. Carpal tunnel release

    Larsen, Morten Bo; Sørensen, A I; Crone, K L;


    A single-blind, randomized, controlled trial was done to compare the results of carpal tunnel release using classic incision, short incision, or endoscopic technique. In total, 90 consecutive cases were included. Follow-up was 24 weeks. We found a significantly shorter sick leave in the endoscopi...... incision could be found. There were no serious complications in either group. The results indicate that the endoscopic procedure is safe and has the benefit of faster rehabilitation and return to work....

  18. Cryogenic hydrogen release research.

    LaFleur, Angela Christine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    The objective of this project was to devolop a plan for modifying the Turbulent Combustion Laboratory (TCL) with the necessary infrastructure to produce a cold (near liquid temperature) hydrogen jet. The necessary infrastructure has been specified and laboratory modifications are currently underway. Once complete, experiments from this platform will be used to develop and validate models that inform codes and standards which specify protection criteria for unintended releases from liquid hydrogen storage, transport, and delivery infrastructure.

  19. EIA new releases


    This report was prepared by the Energy Information Administration. It contains news releases on items of interest to the petroleum, coal, nuclear, electric and alternate fuels industries ranging from economic outlooks to environmental concerns. There is also a listing of reports by industry and an energy education resource listing containing sources for free or low-cost energy-related educational materials for educators and primary and secondary students.

  20. Contact: Releasing the news

    Pinotti, Roberto

    The problem of mass behavior after man's future contacts with other intelligences in the universe is not only a challenge for social scientists and political leaders all over the world, but also a cultural time bomb as well. In fact, since the impact of CETI (Contact with Extraterrestrial Intelligence) on human civilization, with its different cultures, might cause a serious socio-anthropological shock, a common and predetermined worldwide strategy is necessary in releasing the news after the contact, in order to keep possible manifestations of fear, panic and hysteria under control. An analysis of past studies in this field and of parallel historical situations as analogs suggests a definite "authority crisis" in the public as a direct consequence of an unexpected release of the news, involving a devastating "chain reaction" process (from both the psychological and sociological viewpoints) of anomie and maybe the collapse of today's society. The only way to prevent all this is to prepare the world's public opinion concerning contact before releasing the news, and to develop a long-term strategy through the combined efforts of scientists, political leaders, intelligence agencies and the mass media, in order to create the cultural conditions in which a confrontation with ETI won't affect mankind in a traumatic way. Definite roles and tasks in this multi-level model are suggested.

  1. Generation and release of radioactive gases in LLW disposal facilities

    Yim, M.S. [Harvard School Public Health, Boston, MA (United States); Simonson, S.A. [Massachusetts Institute of Technology, Cambridge, MA (United States)


    The atmospheric release of radioactive gases from a generic engineered LLW disposal facility and its radiological impacts were examined. To quantify the generation of radioactive gases, detailed characterization of source inventory for carbon-14, tritium, iodine-129, krypton-85, and radon-222, was performed in terms of their activity concentrations; their distribution within different waste classes, waste forms and containers; and their subsequent availability for release in volatile or gaseous form. The generation of gases was investigated for the processes of microbial activity, radiolysis, and corrosion of waste containers and metallic components in wastes. The release of radionuclides within these gases to the atmosphere was analyzed under the influence of atmospheric pressure changes.

  2. Mechanisms of HSP72 release

    Alexzander Asea


    Currently two mechanisms are recognized by which heat shock proteins (HSP) are released from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma, surgery and following infection with lytic viruses, and an active release mechanism which involves the non classical protein release pathway. HSPs are released both as free HSP and within exosomes. This review covers recent findings on the mechanism by which stress induces the release of HSP72 into the circulation and the biological significance of circulating HSP72 to host defense against disease.

  3. Triggered Release from Polymer Capsules

    Esser-Kahn, Aaron P. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry; Odom, Susan A. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry; Sottos, Nancy R. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Materials Science and Engineering; White, Scott R. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Aerospace Engineering; Moore, Jeffrey S. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry


    Stimuli-responsive capsules are of interest in drug delivery, fragrance release, food preservation, and self-healing materials. Many methods are used to trigger the release of encapsulated contents. Here we highlight mechanisms for the controlled release of encapsulated cargo that utilize chemical reactions occurring in solid polymeric shell walls. Triggering mechanisms responsible for covalent bond cleavage that result in the release of capsule contents include chemical, biological, light, thermal, magnetic, and electrical stimuli. We present methods for encapsulation and release, triggering methods, and mechanisms and conclude with our opinions on interesting obstacles for chemically induced activation with relevance for controlled release.

  4. Protecting privacy in data release

    Livraga, Giovanni


    This book presents a comprehensive approach to protecting sensitive information when large data collections are released by their owners. It addresses three key requirements of data privacy: the protection of data explicitly released, the protection of information not explicitly released but potentially vulnerable due to a release of other data, and the enforcement of owner-defined access restrictions to the released data. It is also the first book with a complete examination of how to enforce dynamic read and write access authorizations on released data, applicable to the emerging data outsou

  5. Effect of pressure of supercritical carbon dioxide on morphology of wool fibers during dyeing process

    Zheng Lai-Jiu


    Full Text Available In this paper, the effect of pressure release rate on dyeing of wool fibers was studied in the supercritical carbon dioxide dyeing. Surface morphology, chemical composition and color difference at different pressure release rates were investigated by employing scanning electron microscope, color matching, and measuring instrument. Experiment data reveal that wool fibers are easy to be damaged with increasing pressure release rate. Fiber’s surface brightness varies also with the pressure release rate. The phenomena are theoretically explained using Bernoulli's principle.

  6. Space and Missile Systems Center Standard: Space Flight Pressurized Systems


    pressure and vehicle structural loads. The main propellant tank of a launch vehicle is a typical example. Pressurized System: A system that...SPACE AND MISSILE SYSTEMS CENTER STANDARD SPACE FLIGHT PRESSURIZED SYSTEMS APPROVED FOR PUBLIC RELEASE...Space Flight Pressurized Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER

  7. Dreams collide with reality for international experiment

    Cho, Adrian


    "Three weeks ago, an international team released a design and cost estimate for the International Linear Collider (ILC). American physicists want to build the ILC at Fermi National Accelerator Laboratory (Fermilab) in Batavia, Illinois, and researchers had hoped to break ground in 2012 and fire up the ILC's beams of electrons and positrons in 2019." (1 page)

  8. Publishing papers in international journals


    @@ INTRODUCTIONThere is increasing pressure for scientists in all countries, including China,to publish their research in international journals.This is necessary for personal careers,as well as for the reputations of universities and other research organizations.Additionally,with the continued growth in international scientific research and the speed with which advances are being made,and active and successful researcher needs to take part in the global circulation of results and information on new technologies.

  9. Recent Developments in Simulations of Internal Flows in High Pressure Swirl Injectors Progrès récents dans la simulation des écoulements dans les injecteurs haute pression à swirl

    Ren W. M.


    Full Text Available As far as design of direct injection spark ignited engine is concerned, the fuel injector is a key component for success. Internal flow simulation is the best adapted tool for the design of the internal geometry of the injector. First, simulations of the internal flow will be discussed, especially transient stages of an injection event as well as the prediction of the fuel characteristics at the nozzle exit. Second, a coupling between internal flow calculations and instability model in order to predict initial spray characteristics will be suggested. L'injecteur est un des éléments clés dans la conception des moteurs essence à injection directe. La modélisation de l'écoulement dans l'injecteur guide la conception de la géométrie interne. Dans une première partie, les aspects de cette modélisation seront soulevés, à savoir, l'écoulement transitoire en début et fin d'injection, ainsi que la prédiction des caractéristiques du carburant à la sortie de l'injecteur qui va conditionner les caractéristiques du spray. Dans une deuxième partie, nous évoquerons les théories d'instabilités à l'origine de la formation des sprays, ainsi que l'approche employée pour prédire les caractéristiques des gouttes générées.

  10. Determination of fission gas release of spent nuclear fuel in puncturing test and in leaching experiments under anoxic conditions

    González-Robles, E.; Metz, V.; Wegen, D. H.; Herm, M.; Papaioannou, D.; Bohnert, E.; Gretter, R.; Müller, N.; Nasyrow, R.; de Weerd, W.; Wiss, T.; Kienzler, B.


    During reactor operation the fission gases Kr and Xe are formed within the UO2 matrix of nuclear fuel. Their quantification is important to evaluate their impact on critical parameters regarding the fuel behaviour during irradiation and (long-term) interim storage, such as internal pressure of the fuel rod and fuel swelling. Moreover the content of Kr and Xe in the plenum of a fuel rod and their content in the UO2 fuel itself are widely used as indicators for the release properties of 129I, 137Cs, and other safety relevant radionuclides with respect to final disposal of spent nuclear fuel. The present study deals with the fission gas release from spent nuclear fuel exposed to simulated groundwater in comparison with the fission gas previously released to the fuel rod plenum during irradiation in reactor. In a unique approach we determined both the Kr and Xe inventories in the plenum by means of a puncturing test and in leaching experiments with a cladded fuel pellet and fuel fragments in bicarbonate water under 3.2 bar H2 overpressure. The fractional inventory of the fission gases released during irradiation into the plenum was (8.3 ± 0.9) %. The fraction of inventory of fission gases released during the leaching experiments was (17 ± 2) % after 333 days of leaching of the cladded pellet and (25 ± 2) % after 447 days of leaching of the fuel fragments, respectively. The relatively high release of fission gases in the experiment with fuel fragments was caused by the increased accessibility of water to the Kr and Xe occluded in the fuel.

  11. Numerical analysis of pressure fluctuation of internal flow in submersible axial-flow pump%潜水轴流泵内部流场压力脉动的数值模拟

    张玉新; 王秀叶; 丁鹏; 唐学林


    The pressure fluctuation in flow field has important influence on the operation stability of axial-flow pumps.In order to precisely analyze the pressure fluctuation in submersible axial-flow pumps,the RNG k-εturbulence model and SIMPLEC algorithm were adopted to investigate the three dimensional turbulent flow and the pressure fluctuation in an axial-flow pump.The calculated results show that the predicted performance curves of pump were in good agreement with the experiment.The maximum amplitude of the pressure fluctuation occurs at the inlet of the impeller,and the main fre-quency of the pressure fluctuation inside the pump is the same as the blade passing frequency when the pressure fluctuation behind the guide-vanes is dominated by low-frequency.From hub to tip of the blade surface,the low frequency components of the fluctuation decreases .On the pressure surface of the blade,the pressure fluctuation amplitude decreases from tip to hub and increases from inlet to out-let of the impe-ller.The fluctuation amplitude on the outer tip is 1 .22 times higher than that on the hub at the inlet.On the suction surface,the pressure fluctuation amplitude on tip is 1.77 times of thehub at the inlet and is 0.92 times of the hub at the outlet of the impeller.The amplitude on the suctionsurface is significantly less than that on the pressure surface of the blade.At the inlet of the impeller,the maximum amplitude of the pressure fluctuation happens at 0.8Q flow rate which is about twice thevalue at the design flow rate.The abovesimulated results can provide some references for further analyzing the pressure fluctuation of axialflow pumps.%流场压力脉动对轴流泵的运行稳定性具有重要影响,为了准确分析潜水轴流泵的压力脉动特性,采用RNG k-ε湍流模型和SIMPLEC算法,对ZQA系列潜水轴流泵进行了全流道三维流动数值模拟和压力脉动分析.计算结果表明:轴流泵的扬程、功率、效率等外特性

  12. Release of charges under external fields of PbLa(Zr,Sn,Ti)O3 ceramic

    Zhang Chong-Hui; Xu Zhuo; Gao Jun-Jie; Yao Xi


    This paper investigates the pyroelectric of poled antiferroelectric (AFE) ceramic Pb0.97La0.02 (Zr0.69Sn0.196 Ti0.114)O3 and its remnant polarization dependence of hydrostatic pressure. The results show that the bound charges of poled sample can be released in short time by temperature field or pressure field. The released charge abruptly forms a large pulse current. The phenomena of released charge under external fields result in the ferroelectric-AFE phase transition induced by temperature or hydrostatic pressure.

  13. International Health

    ... create refugee populations with immediate and long-term health problems. Some of the major diseases currently affecting ... also an international problem which can affect people's health. Many countries and health organizations are working together ...

  14. International Reports.

    Valauskas, Edward J.; Stowe, Jennifer L.; Haycock, Ken; Dodd, Frances


    Presents three reports: International Federation of Library Associations and Institutions; Special Libraries Association; and Canadian library trends, focusing on information technology and access to information and rights and examining provincial libraries and library education. (PEN)

  15. Juris International

    A database on international trade law aimed at lawyers and legal counsel in developing and transition economies. Juris International is a multilingual collection (English, Spanish, and French) of legal information on international trade. Juris International aims to facilitate and reduce the work involved in research for business lawyers, advisers and in-house counsel, and state organizations in developing nd transition economies, by providing access to texts which have often been difficult to obtain. Its objective is to gather a large quantity of basic information at one site (favoring complete legal texts), without the need to send for the information, and consequently without excessive communication costs for users who d benefit from an efficient and cheap telecommunications network.

  16. Allegheny County Toxics Release Inventory

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — The Toxics Release Inventory (TRI) data provides information about toxic substances released into the environment or managed through recycling, energy recovery, and...

  17. Internal education

    Anita Zagorc


    Research Question (RQ): The importance of internal trainings in an organization. Purpose: The purpose of research is to examine and present internal trainings in an organization and their contribution to greater success of an organization. The paper studies employee training in a company, how the organization itself looks after its employees during training, how trainings contribute to further development of organization and the advancement of knowledge for successful operation of organi...

  18. Assembly of bio-nanoparticles for double controlled drug release.

    Wei Huang

    Full Text Available A critical limiting factor of chemotherapy is the unacceptably high toxicity. The use of nanoparticle based drug carriers has significantly reduced the side effects and facilitated the delivery of drugs. Source of the remaining side effect includes (1 the broad final in vivo distribution of the administrated nanoparticles, and (2 strong basal drug release from nanoparticles before they could reach the tumor. Despite the advances in pH-triggered release, undesirable basal drug release has been a constant challenge under in vivo conditions. In this study, functionalized single walled carbon nanohorn supported immunoliposomes were assembled for paclitaxel delivery. The immunoliposomes were formulated with polyethylene glycol, thermal stable and pH sensitive phospholipids. Each nanohorn was found to be encapsulated within one immunoliposome. Results showed a highly pH dependent release of paclitaxel in the presence of serum at body temperature with minimal basal release under physiological conditions. Upon acidification, paclitaxel was released at a steady rate over 30 days with a cumulative release of 90% of the loaded drug. The drug release results proved our hypothesized double controlled release mechanism from the nanoparticles. Other results showed the nanoparticles have doubled loading capacity compared to that of traditional liposomes and higher affinity to breast cancer cells overexpressing Her2 receptors. Internalized nanoparticles were found in lysosomes.

  19. Flavor release measurement from gum model system

    Ovejero-López, I.; Haahr, Anne-Mette; van den Berg, Frans W.J.


    Flavor release from a mint-flavored chewing gum model system was measured by atmospheric pressure chemical ionization mass spectroscopy (APCI-MS) and sensory time-intensity (TI). A data analysis method for handling the individual curves from both methods is presented. The APCI-MS data are ratio...... composition can be measured by both instrumental and sensory techniques, providing comparable information. The peppermint oil level (0.5-2% w/w) in the gum influenced both the retronasal concentration and the perceived peppermint flavor. The sweeteners' (sorbitol or xylitol) effect is less apparent. Sensory...

  20. Heat release mechanism of energetics

    Kubota, N. [Third Research Center, Technical Research and development Institute (Japan)


    Determination of the heat release mechanism of energetic materials is a major subject of combustion study. In order to elucidate the combustion process of various types of energetic materials a generalized combustion wave structure was proposed and the heat release process was discussed. The heat release process was significantly different between the physical structures of the materials: homogeneous and heterogeneous materials. The thermal structure of an azide polymer was evaluated to demonstrate the heat release mechanism. (author) 6 refs.

  1. Low Blood Pressure

    ... a problem. Sometimes blood pressure that is too low can also cause problems. Blood pressure is the ... reading is 90/60 or lower, you have low blood pressure. Some people have low blood pressure ...

  2. Normal Pressure Hydrocephalus (NPH)

    ... your local chapter Join our online community Normal Pressure Hydrocephalus (NPH) Normal pressure hydrocephalus is a brain ... About Symptoms Diagnosis Causes & risks Treatments About Normal Pressure Hydrocephalus Normal pressure hydrocephalus occurs when excess cerebrospinal ...

  3. Hypertension (High Blood Pressure)

    ... Surgery? A Week of Healthy Breakfasts Shyness Hypertension (High Blood Pressure) KidsHealth > For Teens > Hypertension (High Blood Pressure) Print ... rest temperature diet emotions posture medicines Why Is High Blood Pressure Bad? High blood pressure means a person's heart ...

  4. Energy release in driven twisted coronal loops

    Bareford, M R; Browning, P K; Hood, A W


    In the present study we investigate magnetic reconnection in twisted magnetic fluxtubes with different initial configurations. In all considered cases, energy release is triggered by the ideal kink instability, which is itself the result of applying footpoint rotation to an initially potential field. The main goal of this work is to establish the influence of the field topology and various thermodynamic effects on the energy release process. Specifically, we investigate convergence of the magnetic field at the loop footpoints, atmospheric stratification, as well as thermal conduction. In all cases, the application of vortical driving at the footpoints of an initally potential field leads to an internal kink instability. With the exception of the curved loop with high footpoint convergence, the global geometry of the loop change little during the simulation. Footpoint convergence, curvature and atmospheric structure clearly influences the rapidity with which a loop achieves instability as well as the size of t...

  5. Is bioexsiccation releasing dioxins?

    Benfenati, E.; Mariani, G.; Lodi, M.; Reitano, G.; Fanelli, R. [' ' Mario Negri' ' Institute for Pharmacological Research, Milan (Italy)


    Bioexsiccation is a relatively new process to treat urban solid wastes. We studied the possible release of dioxins from this process, measuring dioxin concentration in the emissions from a bioexsiccation plant. As a comparison, we measured atmospheric levels nearby the plant. The biofilter treating gaseous emissions was also evaluated to assess its efficiency. Dioxin concentrations in the biofilter effluent were lower than both those before the biofilter and the nearby atmosphere. In the last years the management and treatment of solid urban wastes produced some improved processes, in a general attempt to cope with the problem of the huge amount of wastes produced by the modern society. Bio-exsiccation of waste aims at affording a much more biologically inert and manageable material compared to the original waste. In this process the urban solid waste is kept under an air stream for about two weeks. The waste undergoes biological transformation, due to fermentation, which produces an increase of the temperature up to 60-70 C. At the end of the process the weight waste is typically reduced by one third, due to the loss of water and to the degradation of putrescible compounds. Since this is a relatively new industrial process, we studied the possible release of dioxins in the atmospheric emissions of the bioexsiccation plant.

  6. TDC Offset Estimation from Motored Cylinder Pressure Data based on Heat Release Shaping Estimation du décalage de PMH à partir de données de pression de cylindre moteur basées sur la conformation de libération de chaleur

    Tunestål P.


    Full Text Available Finding the correct Top Dead Center (TDC offset for an internal combustion engine is harder than it seems. This study introduces a novel method to find the TDC offset based on the simple assumption that the heat loss power through the combustion chamber walls is constant for motored cycles in a narrow Crank Angle interval around TDC. The proposed method uses nonlinear least squares optimization to find the combination of specific heat ratio and TDC offset that makes the heat loss power as constant as possible. An important subproblem is to determine the peak pressure location with high accuracy. Fitting a third order Fourier series to the motored cylinder pressure allows the pressure maximum to be estimated with a standard deviation of 0.005° Crank Angle (CA and it can also be used instead of the measured pressure to reduce the uncertainty of the TDC estimate by approximately 50%. The standard deviation of a single-cycle TDC estimate is approximately 0.025° CA when using a crank resolution of 0.2° CA for the measurements. The bias of the TDC estimate is in the 0-0.02° CA range both when comparing to measurements with a TDC sensor and with simulated motored cycles. The method can be used both for calibration and on-board diagnostics purposes e.g. during cranking, fuel cut-off or engine switch-off. The third order Fourier series fit comes with a significant computational penalty but since it is only applied very intermittently this does not have to be a serious issue. La détermination du décalage de Point Mort Haut (PMH correct d’un moteur à combustion interne est plus difficile qu’il n’y paraît. Cette étude introduit une nouvelle méthode destinée à déterminer le décalage de PMH sur la base de la simple supposition que la puissance de perte de chaleur à travers les parois de la chambre de combustion soit constante pour des cycles moteur selon un intervalle d’angle de bras de manivelle étroit autour du PMH. La m

  7. Control Techtronics International

    West, J.


    Polish graded coal can be burned in existing stoker boilers and meet the 1998 Air Quality standard. This is accomplished with the Control Techtronics microprocessor-based combustion controller accurately and repeatedly: (a) matching the combustion air to the coal firing rate, with continuous stack sensor feedback; (b) continuously varying the boiler`s firing rate based on output water temperature or steam pressure; (c) continuously varying the exhaust fan`s speed to maintain minimum negative pressure in the boiler`s combustion chamber; and recirculating a portion of the flue gas, at varying amounts throughout the boiler`s firing rate. Systems for five boilers have been installed and are operating on MPEC`s Balicka plant in Krakow. Control Techtronics International has $10 million of U.S. Export-Import Bank funds available for similar projects throughout Poland.

  8. The impact of emergency release in LNG transfer

    Bokhorst, E. van; Webber, T.; Putte, L.J. van der; Smeulers, J.P.M.; Remans, D.


    This paper describes the results of experimental work and simulations of pressure surges resulting from fast closing valves and activation of an emergency release coupling (ERC) in ship-to-ship LNG transfer. The first part presents the results of an ambient water flow test with a fast closing 4-inch

  9. 40 CFR 63.165 - Standards: Pressure relief devices in gas/vapor service.


    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Standards: Pressure relief devices in gas/vapor service. 63.165 Section 63.165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Standards: Pressure relief devices in gas/vapor service. (a) Except during pressure releases, each pressure...

  10. 40 CFR 265.1054 - Standards: Pressure relief devices in gas/vapor service.


    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Standards: Pressure relief devices in gas/vapor service. 265.1054 Section 265.1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...: Pressure relief devices in gas/vapor service. (a) Except during pressure releases, each pressure relief...

  11. Teaming Up Against High Blood Pressure


    This podcast is based on the September 2012 CDC Vital Signs report. A team-based approach by patients, health care systems, and health care providers is one of the best ways to treat uncontrolled high blood pressure.  Created: 9/4/2012 by Centers for Disease Control and Prevention (CDC).   Date Released: 9/4/2012.

  12. Release isentrope measurements with the LLNL electric gun

    Gathers, G.R.; Osher, J.E.; Chau, H.H.; Weingart, R.C.; Lee, C.G.; Diaz, E.


    The liquid-vapor coexistence boundary is not well known for most metals because the extreme conditions near the critical point create severe experimental difficulties. The isentropes passing through the liquid-vapor region typically begin from rather large pressures on the Hugoniot. We are attempting to use the high velocities achievable with the Lawrence Livermore National Laboratory (LLNL) electric gun to obtain these extreme states in aluminum and measure the release isentropes by releasing into a series of calibrated standards with known Hugoniots. To achieve large pressure drops needed to explore the liquid-vapor region, we use argon gas for which Hugoniots have been calculated using the ACTEX code, as one of the release materials.

  13. Release-ability of nano fillers from different nanomaterials (toward the acceptability of nanoproduct)

    Golanski, L.; Guiot, A.; Pras, M.; Malarde, M.; Tardif, F.


    It is of great interest to set up a reproducible and sensitive method able to qualify nanomaterials before their market introduction in terms of their constitutive nanoparticle release-ability in usage. Abrasion was performed on polycarbonate, epoxy, and PA11 polymers containing carbone nanotubes (CNT) up to 4 %wt. Using Taber linear standard tool and standard abrasion conditions no release from polymer coatings containing CNT was measured. In this study, new practical tools inducing non-standardized stresses able to compete with van der Waals forces were developed and tested on model polymers, showing controlled CNT dispersion. These stresses are still realistic, corresponding to scratching, instantaneous mechanical shocks, and abrasion of the surface. They offer an efficient way to quantify if release is possible from nanomaterials under different mechanical stresses and therefore give an idea about the mechanisms that favors it. Release under mechanical shocks and hard abrasion was obtained using these tools but only when nanomaterials present a bad dispersion of CNT within the epoxy matrix. Under the same conditions no release was obtained from the same material presenting a good dispersion. The CNT used in this study showed an external diameter Dext = 12 nm, an internal diameter Din = 5 nm, and a mean length of 1 μm. Release from paints under hard abrasion using a standard rotative Taber tool was obtained from a intentionaly non-optimized paint containing SiO2 nanoparticles up to 35 %wt. The primary diameter of the SiO2 was estimated to be around 12 nm. A metallic rake was efficient to remove nanoparticles from a non-woven fabric nanomaterial.

  14. Release-ability of nano fillers from different nanomaterials (toward the acceptability of nanoproduct)

    Golanski, L., E-mail:; Guiot, A. [CEA-Grenoble, LITEN (France); Pras, M. [Institut National des Sciences Appliquees de Lyon, Laboratoire des Materiaux Macromoleculaires (France); Malarde, M.; Tardif, F. [CEA-Grenoble, LITEN (France)


    It is of great interest to set up a reproducible and sensitive method able to qualify nanomaterials before their market introduction in terms of their constitutive nanoparticle release-ability in usage. Abrasion was performed on polycarbonate, epoxy, and PA11 polymers containing carbone nanotubes (CNT) up to 4 %wt. Using Taber linear standard tool and standard abrasion conditions no release from polymer coatings containing CNT was measured. In this study, new practical tools inducing non-standardized stresses able to compete with van der Waals forces were developed and tested on model polymers, showing controlled CNT dispersion. These stresses are still realistic, corresponding to scratching, instantaneous mechanical shocks, and abrasion of the surface. They offer an efficient way to quantify if release is possible from nanomaterials under different mechanical stresses and therefore give an idea about the mechanisms that favors it. Release under mechanical shocks and hard abrasion was obtained using these tools but only when nanomaterials present a bad dispersion of CNT within the epoxy matrix. Under the same conditions no release was obtained from the same material presenting a good dispersion. The CNT used in this study showed an external diameter Dext = 12 nm, an internal diameter Din = 5 nm, and a mean length of 1 {mu}m. Release from paints under hard abrasion using a standard rotative Taber tool was obtained from a intentionaly non-optimized paint containing SiO{sub 2} nanoparticles up to 35 %wt. The primary diameter of the SiO{sub 2} was estimated to be around 12 nm. A metallic rake was efficient to remove nanoparticles from a non-woven fabric nanomaterial.

  15. Attentional priming releases crowding.

    Kristjánsson, Arni; Heimisson, Pétur Rúnar; Róbertsson, Gunnar Freyr; Whitney, David


    Views of natural scenes unfold over time, and objects of interest that were present a moment ago tend to remain present. While visual crowding places a fundamental limit on object recognition in cluttered scenes, most studies of crowding have suffered from the limitation that they typically involved static scenes. The role of temporal continuity in crowding has therefore been unaddressed. We investigated intertrial effects upon crowding in visual scenes, showing that crowding is considerably diminished when objects remain constant on consecutive visual search trials. Repetition of both the target and distractors decreases the critical distance for crowding from flankers. More generally, our results show how object continuity through between-trial priming releases objects that would otherwise be unidentifiable due to crowding. Crowding, although it is a significant bottleneck on object recognition, can be mitigated by statistically likely temporal continuity of the objects. Crowding therefore depends not only on what is momentarily present, but also on what was previously attended.

  16. Pressure Venting Tests of Phenolic Impregnated Carbon Ablator (PICA)

    Blosser, Max L.; Knutson, Jeffrey R.


    A series of tests was devised to investigate the pressure venting behavior of one of the candidate ablators for the Orion capsule heat shield. Three different specimens of phenolic impregnated carbon ablator (PICA) were instrumented with internal pressure taps and subjected to rapid pressure changes from near vacuum to one atmosphere and simulated Orion ascent pressure histories. The specimens vented rapidly to ambient pressure and sustained no detectable damage during testing. Peak pressure differences through the thickness of a 3-inch-thick specimen were less than 1 psi during a simulated ascent pressure history.

  17. Pressure evolution during HBC fuse operation

    Rochette, D; Bussiere, W [Laboratoire Arc Electrique et Plasmas Thermiques (LAEPT)-CNRS UMR 6069, Universite Blaise Pascal, 24 Avenue des Landais, F 63177 Aubiere Cedex (France)


    The purpose of this paper is to describe the influence of the silica sand grains on pressure during the energy release in a high breaking capacity (HBC) fuse. During the HBC fuse operation, the pressure evolution is the result of two opposite trends: the pressure increase due to the interaction of the silica plasma with the surrounding granular sand, and the pressure decrease due to the propagation of the pressure waves toward the porous medium. Due to the complex phenomena occurring during the current extinction by a fuse, two kinds of pressure are distinguished: the pressure inside the silica plasma and the pressure in the silica sand. From the simulations we show that the Forchheimer flow resistance is stronger than the Darcy flow resistance once the electric power is over 30% of the maximum value. A comparison of the calculated and measured pressures is made at various positions from the fuse element axis. Two different pressures are obtained experimentally: the pressure P{sub SAND} exerted on the sand grains due to the plasma pressure, and the pressure P{sub GAS} of the gas flowing through the interstices of the silica sand. We show that the experimental and calculated trends are similar and they both depend on the electric power level and the silica sand mean granulometry. The maximum pressures are observed at the same time as the maximum electric power levels. The ratio P{sub SAND}/P{sub GAS} is about 8 with P{sub GAS} values not exceeding 1.5 x 10{sup 5} Pa.


    Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan


    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without


    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary


    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners


    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary


    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without