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Sample records for release event behavior

  1. Models for recurrent gas release event behavior in hazardous waste tanks

    International Nuclear Information System (INIS)

    Anderson, D.N.; Arnold, B.C.

    1994-08-01

    Certain radioactive waste storage tanks at the United States Department of Energy Hanford facilities continuously generate gases as a result of radiolysis and chemical reactions. The congealed sludge in these tanks traps the gases and causes the level of the waste within the tanks to rise. The waste level continues to rise until the sludge becomes buoyant and ''rolls over'', changing places with heavier fluid on top. During a rollover, the trapped gases are released, resulting, in a sudden drop in the waste level. This is known as a gas release event (GRE). After a GRE, the wastes leading to another GRE. We present nonlinear time waste re-congeals and gas again accumulates leading to another GRE. We present nonlinear time series models that produce simulated sample paths that closely resemble the temporal history of waste levels in these tanks. The models also imitate the random GRE, behavior observed in the temporal waste level history of a storage tank. We are interested in using the structure of these models to understand the probabilistic behavior of the random variable ''time between consecutive GRE's''. Understanding the stochastic nature of this random variable is important because the hydrogen and nitrous oxide gases released from a GRE, are flammable and the ammonia that is released is a health risk. From a safety perspective, activity around such waste tanks should be halted when a GRE is imminent. With credible GRE models, we can establish time windows in which waste tank research and maintenance activities can be safely performed

  2. An Ilustrative Nuclide Release Behavior from an HLW Repository due to an Earthquake Event

    International Nuclear Information System (INIS)

    Lee, Youn-Myoung; Hwang, Yong-Soo; Choi, Jong-Won

    2008-01-01

    Program for the evaluation of a high-level waste repository which is conceptually modeled. During the last few years, programs developed with the aid of AMBER and GoldSim by which nuclide transports in the near- and far-field of a repository as well as transport through the biosphere under various normal and disruptive release scenarios could be modeled and evaluated, have been continuously demonstrated. To show its usability, as similarly done for the natural groundwater flow scheme, influence of a possible disruptive event on a nuclide release behavior from an HLW repository system caused naturally due to an earthquake has been investigated and illustrated with the newly developed GoldSim program

  3. Deep Sludge Gas Release Event Analytical Evaluation

    International Nuclear Information System (INIS)

    Sams, Terry L.

    2013-01-01

    Long Abstract. Full Text. The purpose of the Deep Sludge Gas Release Event Analytical Evaluation (DSGRE-AE) is to evaluate the postulated hypothesis that a hydrogen GRE may occur in Hanford tanks containing waste sludges at levels greater than previously experienced. There is a need to understand gas retention and release hazards in sludge beds which are 200 -300 inches deep. These sludge beds are deeper than historical Hanford sludge waste beds, and are created when waste is retrieved from older single-shell tanks (SST) and transferred to newer double-shell tanks (DST).Retrieval of waste from SSTs reduces the risk to the environment from leakage or potential leakage of waste into the ground from these tanks. However, the possibility of an energetic event (flammable gas accident) in the retrieval receiver DST is worse than slow leakage. Lines of inquiry, therefore, are (1) can sludge waste be stored safely in deep beds; (2) can gas release events (GRE) be prevented by periodically degassing the sludge (e.g., mixer pump); or (3) does the retrieval strategy need to be altered to limit sludge bed height by retrieving into additional DSTs? The scope of this effort is to provide expert advice on whether or not to move forward with the generation of deep beds of sludge through retrieval of C-Farm tanks. Evaluation of possible mitigation methods (e.g., using mixer pumps to release gas, retrieving into an additional DST) are being evaluated by a second team and are not discussed in this report. While available data and engineering judgment indicate that increased gas retention (retained gas fraction) in DST sludge at depths resulting from the completion of SST 241-C Tank Farm retrievals is not expected and, even if gas releases were to occur, they would be small and local, a positive USQ was declared (Occurrence Report EM-RP--WRPS-TANKFARM-2012-0014, 'Potential Exists for a Large Spontaneous Gas Release Event in Deep Settled Waste Sludge'). The purpose of this technical

  4. Purchase decision involvement: Event management segments and related event behavior

    Science.gov (United States)

    Rodney B. Warnick; David C. Bojanic

    2012-01-01

    The goal of this research was to examine the relationships between different levels of event purchase decision involvement (PDI) segments and their respective event behaviors (e.g., expenditures, travel behavior, event consumption and satisfaction). The specific purpose was to answer two major research questions: 1) Can PDI identify different levels or segments of...

  5. Private events: from methodological behaviorism to interbehaviorism

    OpenAIRE

    Bueno, Roberto; Universidad de San Martín de Porres / Universidad Nacional Federico Villarreal

    2010-01-01

    As supposed events being accessible to a unique observer, private events posit an interesting challenge to a behavioristic psychology. Three historical variants of behaviorism dealt with the problem of private events: methodological behaviorism, radical behaviorism and interbehaviorism. The basic argument of the two last views, and that distinguishes them from the former, is that private events are comprised into the scope of an objective science of behavior. The analysis of these accounts pe...

  6. Tritium behavior intentionally released in the room

    International Nuclear Information System (INIS)

    Kobayashi, K.; Hayashi, T.; Iwai, Y.; Yamanishi, T.; Willms, R. S.; Carlson, R. V.

    2008-01-01

    To construct a fusion reactor with high safety and acceptability, it is necessary to establish and to ensure tritium safe handling technology. Tritium should be well-controlled not to be released to the environment excessively and to prevent workers from excess exposure. It is especially important to grasp tritium behavior in the final confinement area, such as the room and/or building. In order to obtain data for actual tritium behavior in a room and/or building, a series of intentional Tritium Release Experiments (TREs) were planned and carried out within a radiologically controlled area (main cell) at Tritium System Test Assembly (TSTA) in Los Alamos National Laboratory (LANL) under US-JAPAN collaboration program. These experiments were carried out three times. In these experiments, influence of a difference in the tritium release point and the amount of hydrogen isotope for the initial tritium behavior in the room were suggested. Tritium was released into the main cell at TSTA/LANL. The released tritium reached a uniform concentration about 30 - 40 minutes in all the experiments. The influence of the release point and the amount of hydrogen isotope were not found to be important in these experiments. The experimental results for the initial tritium behavior in the room were also simulated well by the modified three-dimensional eddy flow analysis code FLOW-3D. (authors)

  7. CDC releases ventilator-associated events criteria

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2017-01-01

    Full Text Available No abstract available. Article truncated at 150 words. A new term has been coined by the CDC, ventilator-associated events (VAEs (1. In 2011, the CDC convened a working group composed of members of several stakeholder organizations to address the limitations of the definition of ventilator-associated pneumonia (VAP definition (2. The organizations represented in the Working Group include: the Critical Care Societies Collaborative (the American Association of Critical-Care Nurses, the American College of Chest Physicians, the American Thoracic Society, and the Society for Critical Care Medicine; the American Association for Respiratory Care; the Association of Professionals in Infection Control and Epidemiology; the Council of State and Territorial Epidemiologists; the Healthcare Infection Control Practices Advisory Committee’s Surveillance Working Group; the Infectious Diseases Society of America; and the Society for Healthcare Epidemiology of America. VAEs are defined by an increase oxygen (>0.2 in FiO2 or positive end-expiratory pressure (PEEP (≥3 cm H2O, after a previous stable baseline of at least 2 …

  8. Private events: from methodological behaviorism to interbehaviorism

    Directory of Open Access Journals (Sweden)

    Roberto Bueno

    2011-09-01

    Full Text Available As supposed events being accessible to a unique observer, private events posit an interesting challenge to a behavioristic psychology. Three historical variants of behaviorism dealt with the problem of private events: methodological behaviorism, radical behaviorism and interbehaviorism. The basic argument of the two last views, and that distinguishes them from the former, is that private events are comprised into the scope of an objective science of behavior. The analysis of these accounts permits us to confirm a gradual advance in behavior theory, in dealing with this issue, toward a totally monistic view.

  9. Behaviorism, private events, and the molar view of behavior.

    Science.gov (United States)

    Baum, William M

    2011-01-01

    Viewing the science of behavior (behavior analysis) to be a natural science, radical behaviorism rejects any form of dualism, including subjective-objective or inner-outer dualism. Yet radical behaviorists often claim that treating private events as covert behavior and internal stimuli is necessary and important to behavior analysis. To the contrary, this paper argues that, compared with the rejection of dualism, private events constitute a trivial idea and are irrelevant to accounts of behavior. Viewed in the framework of evolutionary theory or for any practical purpose, behavior is commerce with the environment. By its very nature, behavior is extended in time. The temptation to posit private events arises when an activity is viewed in too small a time frame, obscuring what the activity does. When activities are viewed in an appropriately extended time frame, private events become irrelevant to the account. This insight provides the answer to many philosophical questions about thinking, sensing, and feeling. Confusion about private events arises in large part from failure to appreciate fully the radical implications of replacing mentalistic ideas about language with the concept of verbal behavior. Like other operant behavior, verbal behavior involves no agent and no hidden causes; like all natural events, it is caused by other natural events. In a science of behavior grounded in evolutionary theory, the same set of principles applies to verbal and nonverbal behavior and to human and nonhuman organisms.

  10. Behaviorism, Private Events, and the Molar View of Behavior

    Science.gov (United States)

    Baum, William M

    2011-01-01

    Viewing the science of behavior (behavior analysis) to be a natural science, radical behaviorism rejects any form of dualism, including subjective–objective or inner–outer dualism. Yet radical behaviorists often claim that treating private events as covert behavior and internal stimuli is necessary and important to behavior analysis. To the contrary, this paper argues that, compared with the rejection of dualism, private events constitute a trivial idea and are irrelevant to accounts of behavior. Viewed in the framework of evolutionary theory or for any practical purpose, behavior is commerce with the environment. By its very nature, behavior is extended in time. The temptation to posit private events arises when an activity is viewed in too small a time frame, obscuring what the activity does. When activities are viewed in an appropriately extended time frame, private events become irrelevant to the account. This insight provides the answer to many philosophical questions about thinking, sensing, and feeling. Confusion about private events arises in large part from failure to appreciate fully the radical implications of replacing mentalistic ideas about language with the concept of verbal behavior. Like other operant behavior, verbal behavior involves no agent and no hidden causes; like all natural events, it is caused by other natural events. In a science of behavior grounded in evolutionary theory, the same set of principles applies to verbal and nonverbal behavior and to human and nonhuman organisms. PMID:22532740

  11. Spatiotemporal Organization of Energy Release Events in the Quiet Solar Corona

    Science.gov (United States)

    Uritsky, Vadim M.; Davila, Joseph M.

    2014-01-01

    Using data from the STEREO and SOHO spacecraft, we show that temporal organization of energy release events in the quiet solar corona is close to random, in contrast to the clustered behavior of flaring times in solar active regions. The locations of the quiet-Sun events follow the meso- and supergranulation pattern of the underling photosphere. Together with earlier reports of the scale-free event size statistics, our findings suggest that quiet solar regions responsible for bulk coronal heating operate in a driven self-organized critical state, possibly involving long-range Alfvenic interactions.

  12. Altered elementary calcium release events and enhanced calcium release by thymol in rat skeletal muscle.

    Science.gov (United States)

    Szentesi, Péter; Szappanos, Henrietta; Szegedi, Csaba; Gönczi, Monika; Jona, István; Cseri, Julianna; Kovács, László; Csernoch, László

    2004-03-01

    The effects of thymol on steps of excitation-contraction coupling were studied on fast-twitch muscles of rodents. Thymol was found to increase the depolarization-induced release of calcium from the sarcoplasmic reticulum, which could not be attributed to a decreased calcium-dependent inactivation of calcium release channels/ryanodine receptors or altered intramembrane charge movement, but rather to a more efficient coupling of depolarization to channel opening. Thymol increased ryanodine binding to heavy sarcoplasmic reticulum vesicles, with a half-activating concentration of 144 micro M and a Hill coefficient of 1.89, and the open probability of the isolated and reconstituted ryanodine receptors, from 0.09 +/- 0.03 to 0.22 +/- 0.04 at 30 micro M. At higher concentrations the drug induced long-lasting open events on a full conducting state. Elementary calcium release events imaged using laser scanning confocal microscopy in the line-scan mode were reduced in size, 0.92 +/- 0.01 vs. 0.70 +/- 0.01, but increased in duration, 56 +/- 1 vs. 79 +/- 1 ms, by 30 micro M thymol, with an increase in the relative proportion of lone embers. Higher concentrations favored long events, resembling embers in control, with duration often exceeding 500 ms. These findings provide direct experimental evidence that the opening of a single release channel will generate an ember, rather than a spark, in mammalian skeletal muscle.

  13. Preventing Buoyant Displacement Gas Release Events in Hanford Double-Shell Waste Tanks

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Perry A.; Stewart, Charles W.

    2001-01-01

    This report summarizes the predictive methods used to ensure that waste transfer operations in Hanford waste tanks do not create waste configurations that lead to unsafe gas release events. The gas release behavior of the waste in existing double-shell tanks has been well characterized, and the flammable gas safety issues associated with safe storage of waste in the current configuration are being formally resolved. However, waste is also being transferred between double-shell tanks and from single-shell tanks into double-shell tanks by saltwell pumping and sluicing that create new wastes and waste configurations that have not been studied as well. Additionally, planning is underway for various waste transfer scenarios to support waste feed delivery to the proposed vitrification plant. It is critical that such waste transfers do not create waste conditions with the potential for dangerous gas release events.

  14. Angular power spectrum in publically released ALICE events

    Science.gov (United States)

    Llanes-Estrada, Felipe J.; Muñoz Martinez, Jose L.

    2018-02-01

    We study the particles emitted in the fireball following a Relativistic Heavy Ion Collision with the traditional angular analysis employed in cosmology and earth sciences, producing Mollweide plots of the number and pt distribution of a few actual, publically released ALICE-collaboration events and calculating their angular power spectrum. We also examine the angular spectrum of a simple two-particle correlation. While this may not be the optimal way of analyzing heavy ion data, our intention is to provide a one to one comparison to analysis in cosmology. With the limited statistics at hand, we do not find evidence for acoustic peaks but a decrease of Cl that is reminiscent of viscous attenuation, but subject to a strong effect from the rapidity acceptance which probably dominates (so we also subtract the m = 0 component). As an exercise, we still extract a characteristic Silk damping length (proportional to the square root of the viscosity over entropy density ratio) to illustrate the method. The absence of acoustic-like peaks is also compatible with a crossover from the QGP to the hadron gas (because a surface tension at domain boundaries would effect a restoring force that could have driven acoustic oscillations). Presently we do not understand a depression of the l = 6 multipole strength; perhaps ALICE could reexamine it with full statistics.

  15. Fuel behavior and fission product release under HTGR accident conditions

    International Nuclear Information System (INIS)

    Fukuda, K.; Hayashi, K.; Shiba, K.

    1990-01-01

    In early 1989 a final decision was made over construction of a 30 MWth HTGR called the High Temperature Engineering Test Reactor, HTTR, in Japan in order to utilize it for high temperature gas engineering tests and various nuclear material tests. The HTTR fuel is a pin-in-block type fuel element which is composed of a hexagonal graphite block with dimension of 580 mm in length and 360 mm in face-to-face distance and about 30 of the fuel rods inserted into the coolant channels drilled in the block. The TRISO coated fuel particles for HTTR are incorporated with graphite powder and phenol resin into the fuel compacts, 19 of which are encased into a graphite sleeve as a fuel rod. It is necessary for the HTTR licensing to prove the fuel stability under predicted accidents related to the high temperature events. Therefore, the release of the fission products and the fuel failure have been investigated in the irradiation---and the heating experiments simulating these conditions at JAERI. This report describes the HTTR fuel behavior at extreme temperature, made clear in these experiments

  16. Release behavior of drugs from various natural gums and polymers.

    Science.gov (United States)

    Singh, Anupama; Sharma, Pramod Kumar; Malviya, Rishabha

    2011-01-01

    Polymers are the high molecular weight compounds of natural or synthetic origin, widely used in drug delivery of formulations. These polymers are further classified as hydrophilic or hydrophobic in nature. Depending upon this characteristic, polymers exhibit different release behavior in different media. This property plays an important role in the selection of polymers for controlled, sustained or immediate release formulations. The review highlights the literatures related to the research made on several polymers regarding the release kinetics which made them a novel approach for modifying the action of the particular formulation.

  17. Altered Elementary Calcium Release Events and Enhanced Calcium Release by Thymol in Rat Skeletal Muscle

    OpenAIRE

    Szentesi, Péter; Szappanos, Henrietta; Szegedi, Csaba; Gönczi, Monika; Jona, István; Cseri, Julianna; Kovács, László; Csernoch, László

    2004-01-01

    The effects of thymol on steps of excitation-contraction coupling were studied on fast-twitch muscles of rodents. Thymol was found to increase the depolarization-induced release of calcium from the sarcoplasmic reticulum, which could not be attributed to a decreased calcium-dependent inactivation of calcium release channels/ryanodine receptors or altered intramembrane charge movement, but rather to a more efficient coupling of depolarization to channel opening. Thymol increased ryanodine bind...

  18. Event-governed and verbally-governed behavior.

    Science.gov (United States)

    Vargas, E A

    1988-01-01

    A NUMBER OF STATEMENTS PRESCRIBE BEHAVIOR: apothegms, maxims, proverbs, instructions, and so on. These differing guides to conduct present varieties of the dictionary definition of "rules." The term "rules" thus defines a category of language usage. Such a term, and its derivative, "rule-governed," does not address a controlling relation in the analysis of verbal behavior. The prevailing confounding of a category of language with a category of verbal behavior appears related to a lack of understanding as to what distinguishes verbal behavior from other behavior. Verbal behavior is a behavior-behavior relation in which events are contacted through the mediation of another organism's behavior specifically shaped for such mediation by a verbal community. It contrasts with behavior that contacts events directly, and shaped directly by the features of those events. Thus we may distinguish between two large classes of behavior by whether it is behavior controlled by events, or behavior controlled verbally. However, the functional controls operative with both classes of behavior do not differ.

  19. New York hazardous substances emergency events surveillance: learning from hazardous substances releases to improve safety

    International Nuclear Information System (INIS)

    Welles, Wanda Lizak; Wilburn, Rebecca E.; Ehrlich, Jenny K.; Floridia, Christina M.

    2004-01-01

    Since 1993, the New York State Department of Health, funded by the Agency for Toxic Substances and Disease Registry, has collected data about non-petroleum hazardous substances releases through the Hazardous Substances Emergency Events Surveillance (NYHSEES) project. This study investigates risk factors for hazardous substances releases that may result in public health consequences such as injury or reported health effects. The 6428 qualifying events that occurred during the 10-year-period of 1993-2002 involved 8838 hazardous substances, 842 evacuations, more than 75,419 people evacuated, and more than 3120 people decontaminated. These events occurred both at fixed facilities (79%) and during transport (21%). The causative factors most frequently contributing to reported events were equipment failure (39%) and human error (33%). Five of the 10 chemicals most frequently associated with injuries were also among the 10 chemicals most frequently involved in reported events: sulfuric acid, hydrochloric acid, ammonia, sodium hypochlorite, and carbon monoxide. The chemical categories most frequently associated with events, and with events with adverse health effects were volatile organic compounds (VOCs) and solvents, and acids. Events with releases of hazardous substances were associated with injuries to 3089 people including employees (37%), responders (12%), the general public (29%) and students (22%). The most frequently reported adverse health effects were respiratory irritation, headache, and nausea or vomiting. Most of the injured were transported to the hospital, treated, and released (55%) or treated at the scene (29%). These data have been used for emergency response training, planning, and prevention activities to reduce morbidity and mortality from future events

  20. Kids Speak: Preferred Parental Behavior at Youth Sport Events

    Science.gov (United States)

    Omli, Jens; Wiese-Bjornstal, Diane M.

    2011-01-01

    News reports (e.g., Abrams, 2008) and scholarly research (e.g., Wiersma & Fifer, 2005) have indicated increasing concern that parent-spectator behavior at youth sport events may be problematic. Multiple strategies have been used to influence spectator behavior in youth sport contexts (e.g., "Silent Sundays"). However, it is unlikely that…

  1. Behavioral event occurrence differs between behavioral states in Sotalia guianensis (Cetarctiodactyla: Delphinidae dolphins: a multivariate approach

    Directory of Open Access Journals (Sweden)

    Rodrigo H. Tardin

    2014-02-01

    Full Text Available Difficulties in quantifying behavioral events can cause loss of information about cetacean behavior, especially behaviors whose functions are still debated. The lack of knowledge is greater for South American species such as Sotalia guianensis (Van Benédén, 1864. Our objective was to contextualize the behavioral events inside behavioral states using a Permutational Multivariate Analysis of Variance (MANOVA. Three events occurred in the Feeding, Socio-Sexual and Travelling states (Porpoising, Side flop, Tail out dive, and five events occurred in the Feeding and Travelling states (Back flop, Horizontal jump, Lobtail, Spy-hop, Partial flop ahead. Three events (Belly exposure, Club, and Heading occurred exclusively in the Socio-sexual state. Partial Back flop and Head flop occurred exclusively in the Feeding state. For the events that occurred in multiple states, we observed that some events occurred more frequently in one of the states (p < 0.001, such as Lobtail, Tail out dive horizontal Jump, Partial flop ahead and Side flop. Our multivariate analysis, which separated Socio-sexual behavior from Feeding and Travelling, showed that the abundance of behavioral events differs between states. This differentiation indicates that some events are associated with specific behavioral states. Almost 40% of the events observed were exclusively performed in one state, which indicates a high specialization for some events. Proper discrimination and contextualization of behavioral events may be efficient tools to better understand dolphin behaviors. Similar studies in other habitats and with other species, will help build a broader scenario to aid our understanding of the functions of dolphin behavioral events.

  2. Effects of burnup on fission product release and implications for severe fuel damage events

    International Nuclear Information System (INIS)

    Appelhans, A.D.; Cronenberg, A.W.; Carboneau, M.L.

    1984-01-01

    Xe, Kr, and I fission-product release data from (a) Halden tests where release in intact rods was measured during irradiation at burnups to 18,000 MWd/t and fuel temperatures of 800 to 1800 0 K, and (b) Power Burst Facility (PBF) tests where trace-irradiated fuel (approx. = 90 MWd/t) was driven to temperatures of >2400 0 K and fuel liquefaction occurred are discussed and related to fuel morphology. Results from both indicate that the fission-product morphology and fuel restructuring govern release behavior. The Halden tests show low release at beginning of life with a 10-fold increase at burnups in excess of 10,000 MWd/t, due to the development of grain boundary interlinkage at higher burnups. Such dependence of release on morphology characteristics is consistent with findings from the PBF tests, where for trace-irradiated fuel, the absence of interlinkage accounts for the low release rates observed during initial fuel heatup, with subsequent enhanced Xe, Kr, and I release via liquefaction or quench-induced destruction of the grain structure. Morphology is also shown to influence the chemical release form of I and Cs fission products

  3. Release behavior of triazine residues in stabilised contaminated soils

    International Nuclear Information System (INIS)

    Ying, G.G.; Kookana, R.S.; Mallavarpu, M.

    2005-01-01

    This paper reports the release behavior of two triazines (atrazine and simazine) in stabilised soils from a pesticide-contaminated site in South Australia. The soils were contaminated with a range of pesticides, especially with triazine herbicides. With multiple extractions of each soil sample with deionised water (eight in total), 15% of atrazine and 4% of simazine residues were recovered, resulting in very high concentrations of the two herbicides in leachate. The presence of small fractions of surfactants was found to further enhance the release of the residues. Methanol content up to 10% did not substantially influence the concentration of simazine and atrazine released. The study demonstrated that while the stabilisation of contaminated soil with particulate activated carbon (5%) and cement mix (15%) was effective in locking the residues of some pesticides, it failed to immobilise triazine herbicides residues completely. Given the higher water solubility of these herbicides than other compounds more effective strategies to immobilise their residues is needed. - Stabilisation of contaminated soil with a mix of activated carbon and cement may fail to immobilise some contaminants like triazines

  4. Simulation of tritium behavior after intended tritium release in ventilated room

    International Nuclear Information System (INIS)

    Iwai, Yasunori; Hayashi, Takumi; Yamanishi, Toshihiko; Kobayashi, Kazuhiro; Nishi, Masataka

    2001-01-01

    At the Tritium Process Laboratory (TPL) at the Japan Atomic Energy Research Institute (JAERI), Caisson Assembly for Tritium Safety study (CATS) with 12 m 3 of large airtight vessel (Caisson) was fabricated for confirmation and enhancement of fusion reactor safety to estimate tritium behavior in the case where a tritium leak event should happen. One of the principal objectives of the present studies is the establishment of simulation method to predict the tritium behavior after the tritium leak event should happen in a ventilated room. The RNG model was found to be valid for eddy flow calculation in the 50 m 3 /h ventilated Caisson with acceptable engineering precision. The calculated initial and removal tritium concentration histories after intended tritium release were consistent with the experimental observations in the 50 m 3 /h ventilated Caisson. It is found that the flow near a wall plays an important role for the tritium transport in the ventilated room. On the other hand, tritium behavior intentionally released in the 3,000 m 3 of tritium handling room was investigated experimentally under a US-Japan collaboration. The tritium concentration history calculated with the same method was consistent with the experimental observations, which proves that the present developed method can be applied to the actual scale of tritium handling room. (author)

  5. Ca(2+ release events in cardiac myocytes up close: insights from fast confocal imaging.

    Directory of Open Access Journals (Sweden)

    Vyacheslav M Shkryl

    Full Text Available The spatio-temporal properties of Ca(2+ transients during excitation-contraction coupling and elementary Ca(2+ release events (Ca(2+ sparks were studied in atrial and ventricular myocytes with ultra-fast confocal microscopy using a Zeiss LSM 5 LIVE system that allows sampling rates of up to 60 kHz. Ca(2+ sparks which originated from subsarcolemmal junctional sarcoplasmic reticulum (j-SR release sites in atrial myocytes were anisotropic and elongated in the longitudinal direction of the cell. Ca(2+ sparks in atrial cells originating from non-junctional SR and in ventricular myocytes were symmetrical. Ca(2+ spark recording in line scan mode at 40,000 lines/s uncovered step-like increases of [Ca(2+]i. 2-D imaging of Ca(2+ transients revealed an asynchronous activation of release sites and allowed the sequential recording of Ca(2+ entry through surface membrane Ca(2+ channels and subsequent activation of Ca(2+-induced Ca(2+ release. With a latency of 2.5 ms after application of an electrical stimulus, Ca(2+ entry could be detected that was followed by SR Ca(2+ release after an additional 3 ms delay. Maximum Ca(2+ release was observed 4 ms after the beginning of release. The timing of Ca(2+ entry and release was confirmed by simultaneous [Ca(2+]i and membrane current measurements using the whole cell voltage-clamp technique. In atrial cells activation of discrete individual release sites of the j-SR led to spatially restricted Ca(2+ release events that fused into a peripheral ring of elevated [Ca(2+]i that subsequently propagated in a wave-like fashion towards the center of the cell. In ventricular myocytes asynchronous Ca(2+ release signals from discrete sites with no preferential subcellular location preceded the whole-cell Ca(2+ transient. In summary, ultra-fast confocal imaging allows investigation of Ca(2+ signals with a time resolution similar to patch clamp technique, however in a less invasive fashion.

  6. Conceptualization of Collective Behavior Events in the New York "Times."

    Science.gov (United States)

    Blake, Joseph A.; And Others

    1978-01-01

    Reports that most collective behavior events reported in the New York "Times" are described in terms of emotionality and anonymity of membership and are alleged to be violent and spontaneous, and that there are significant rank-order correlations between the reported presence of control agents, reported violence, and attributions of spontaneity.…

  7. Using random event simulation to evaluate the effectiveness of indoor sheltering during a sour gas release

    International Nuclear Information System (INIS)

    Wilson, D.

    2003-01-01

    In the event of sour gas releases to the atmosphere, there is a strong bias toward evacuation rather than sheltering-in-place. This paper described the critical factors in decision-making for shelter-in-place versus evacuation. These include: delay time expected before release begins; size of potential release, explosion or fire; expected duration; direction to safety for evacuation; the air tightness of the building; and, the number of people in the emergency response zone. A shelter-in-place decision chart developed by the Canadian Association of Fire Chiefs was presented. It shows the usual bias toward evacuation as the default position. It also shows the greatest drawbacks of sheltering-in-place. The main factor in maintaining the effectiveness of the building shelter is the rate of air infiltration into the building. Other issues to consider include: reactive versus passive chemicals in the release; light versus heavy gas releases; building type (houses, high-rise apartments, office buildings, or warehouses); tightness of building construction; whether to turn the house heating and air conditioning on or off during shelter; daytime versus nighttime conditions; and, cost factors. Equations for calculating indoor and outdoor toxic exposure to decide on shelter versus evacuation were also presented. It was concluded that the absence of peak concentrations dramatically reduce the risk of fatality to people sheltering indoors. Keeping people indoors is the best way to assure their safety for the first hour following a toxic release. 8 refs., 6 figs

  8. Initial concepts on energetics and mass releases during nonnuclear explosive events in fuel cycle facilities

    International Nuclear Information System (INIS)

    Halverson, M.A.; Mishima, J.

    1986-09-01

    Non-nuclear explosions are one of the initiating events (accidents) considered in the US Nuclear Regulatory Commission study of formal methods for estimating the airborne release of radionuclides from fuel cycle facilities. Methods currently available to estimate the energetics and mass airborne release from the four types of non-nuclear explosive events (fast and slow physical explosions and fast and slow chemical explosions) are reviewed. The likelihood that fast physical explosions will occur in fuel cycle facilities appears to be remote and this type of explosion is not considered. Methods to estimate the consequences of slow physical and fast chemical explosions are available. Methods to estimate the consequences of slow chemical explosions are less well defined

  9. Concurrent Bursty Behavior of Social Sensors in Sporting Events

    Science.gov (United States)

    Takeichi, Yuki; Sasahara, Kazutoshi; Suzuki, Reiji; Arita, Takaya

    2015-01-01

    The advent of social media expands our ability to transmit information and connect with others instantly, which enables us to behave as “social sensors.” Here, we studied concurrent bursty behavior of Twitter users during major sporting events to determine their function as social sensors. We show that the degree of concurrent bursts in tweets (posts) and retweets (re-posts) works as a strong indicator of winning or losing a game. More specifically, our simple tweet analysis of Japanese professional baseball games in 2013 revealed that social sensors can immediately react to positive and negative events through bursts of tweets, but that positive events are more likely to induce a subsequent burst of retweets. We confirm that these findings also hold true for tweets related to Major League Baseball games in 2015. Furthermore, we demonstrate active interactions among social sensors by constructing retweet networks during a baseball game. The resulting networks commonly exhibited user clusters depending on the baseball team, with a scale-free connectedness that is indicative of a substantial difference in user popularity as an information source. While previous studies have mainly focused on bursts of tweets as a simple indicator of a real-world event, the temporal correlation between tweets and retweets implies unique aspects of social sensors, offering new insights into human behavior in a highly connected world. PMID:26659028

  10. Real time imaging of live cell ATP leaking or release events by chemiluminescence microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yun [Iowa State Univ., Ames, IA (United States)

    2008-12-18

    The purpose of this research was to expand the chemiluminescence microscopy applications in live bacterial/mammalian cell imaging and to improve the detection sensitivity for ATP leaking or release events. We first demonstrated that chemiluminescence (CL) imaging can be used to interrogate single bacterial cells. While using a luminometer allows detecting ATP from cell lysate extracted from at least 10 bacterial cells, all previous cell CL detection never reached this sensitivity of single bacteria level. We approached this goal with a different strategy from before: instead of breaking bacterial cell membrane and trying to capture the transiently diluted ATP with the firefly luciferase CL assay, we introduced the firefly luciferase enzyme into bacteria using the modern genetic techniques and placed the CL reaction substrate D-luciferin outside the cells. By damaging the cell membrane with various antibacterial drugs including antibiotics such as Penicillins and bacteriophages, the D-luciferin molecules diffused inside the cell and initiated the reaction that produces CL light. As firefly luciferases are large protein molecules which are retained within the cells before the total rupture and intracellular ATP concentration is high at the millmolar level, the CL reaction of firefly luciferase, ATP and D-luciferin can be kept for a relatively long time within the cells acting as a reaction container to generate enough photons for detection by the extremely sensitive intensified charge coupled device (ICCD) camera. The result was inspiring as various single bacterium lysis and leakage events were monitored with 10-s temporal resolution movies. We also found a new way of enhancing diffusion D-luciferin into cells by dehydrating the bacteria. Then we started with this novel single bacterial CL imaging technique, and applied it for quantifying gene expression levels from individual bacterial cells. Previous published result in single cell gene expression quantification

  11. Adverse Events With Sustained-Release Donepezil in Alzheimer Disease: Relation to Body Mass Index.

    Science.gov (United States)

    Lee, Chunsoo; Lee, Kyungsang; Yu, Hyewon; Ryu, Seung-Ho; Moon, Seok Woo; Han, Changsu; Lee, Jun-Young; Lee, Young Min; Kim, Shin-Gyeom; Kim, Ki Woong; Lee, Dong Woo; Kim, Seong Yoon; Lee, Sang-Yeol; Bae, Jae Nam; Jung, Young-Eun; Kim, Jeong Lan; Kim, Byung-Soo; Shin, Il-Seon; Kim, Young Hoon; Kim, Bong Jo; Kang, Hyo Shin; Myung, Woojae; Carroll, Bernard J; Kim, Doh Kwan

    2017-08-01

    Sustained-release, high-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD). Based on a previous clinical trial, body weight of less than 55 kg is a risk factor for adverse events with donepezil 23 mg/d treatment in global population. To clarify whether this finding is consistent across ethnic groups that vary in absolute body mass, we recruited Korean patients aged 45 to 90 years with moderate to severe AD who had been receiving standard donepezil immediate release 10 mg/d for at least 3 months. After screening, we analyzed a final cohort of 166 patients who received donepezil 23 mg/d for 24 weeks to compare the occurrence of treatment-emergent adverse events (TEAEs) between patients with high versus low body mass index (BMI) based on the World Health Organization overweight criteria for Asian populations (23 kg/m). Treatment-emergent adverse events were reported by 79.45% of patients in the lower BMI group and 58.06% of patients in the higher BMI group (odds ratio, 2.79; 95% confidence interval, 1.39-5.63; χ = 7.58, P = 0.006). In a multivariable survival analysis, the group with lower BMI showed a higher occurrence of TEAEs (hazard ratio, 1.83; 95% confidence interval, 1.25-2.68; P = 0.002). In Korean patients with moderate to severe AD receiving high-dose donepezil over 24 weeks, TEAEs were significantly more common in those with lower BMI (not clinically overweight), especially nausea. This finding may inform clinical practice for Asian patients.

  12. Integrated performance assessment model for waste policy package behavior and radionuclide release

    International Nuclear Information System (INIS)

    Kossik, R.; Miller, I.; Cunnane, M.

    1992-01-01

    Golder Associates Inc. (GAI) has developed a probabilistic total system performance assessment and strategy evaluation model (RIP) which can be applied in an iterative manner to evaluate repository site suitability and guide site characterization. This paper describes one component of the RIP software, the waste package behavior and radionuclide release model. The waste package component model considers waste package failure by various modes, matrix alteration/dissolution, and radionuclide mass transfer. Model parameters can be described as functions of local environmental conditions. The waste package component model is coupled to component models for far-field radionuclide transport and disruptive events. The model has recently been applied to the proposed repository at Yucca Mountain

  13. Integrated performance assessment model for waste package behavior and radionuclide release

    International Nuclear Information System (INIS)

    Kossik, R.; Miller, I.; Cunnane, M.

    1992-01-01

    Golder Associates Inc. (GAI) has developed a probabilistic total system performance assessment and strategy evaluation model (RIP) which can be applied in an iterative manner to evaluate repository site suitability and guide site characterization. This paper describes one component of the RIP software, the waste package behavior and radionuclide release model. The waste package component model considers waste package failure by various modes, matrix alteration/dissolution, and radionuclide mass transfer. Model parameters can be described as functions of local environmental conditions. The waste package component model is coupled to component models for far-field radionuclide transport and disruptive events. The model has recently been applied to the proposed repository at Yucca Mountain

  14. ARE THERE TWO DISTINCT SOLAR ENERGETIC PARTICLE RELEASES IN THE 2012 MAY 17 GROUND LEVEL ENHANCEMENT EVENT?

    International Nuclear Information System (INIS)

    Ding, Liu-Guan; Jiang, Yong; Li, Gang

    2016-01-01

    We examine ion release times in the solar vicinity for the 2012 May 17 Ground Level Enhancement event using the velocity dispersion analysis method. In situ energetic proton data from Solar and Heliospheric Observatory (SOHO)/Energetic and Relativistic Nuclei and Electron and Geostationary Operational Environmental Satellite are used. We find two distinct releases of Solar Energetic Particles (SEPs) near the Sun, separated by ∼40 minutes. From soft X-ray observations, we find that the first release coincides with the solar flare eruption: the release starts from the flare onset and ends near the peak of the soft X-ray; type-III radio bursts also occur when the release starts. A type II radio burst may also start at the begining of the release. However, the associated Coronal Mass Ejection (CME) only has a height of 0.08R s from extrapolation of SOHO/LASCO data. At the start of the second release, the CME propagates to more than 8.4R s in height, and there are signatures of an enhanced type II radio burst. The time-integrated spectra for the two releases differ. The spectrum for the second release shows the common double-power-law feature of gradual SEP events. The spectrum for the first release does not resemble power laws because there is considerable modulation at lower energies. Based on our analysis, we suggest that SEPs of the first release were dominated by particles accelerated at the flare, and those of the second release were dominated by particles accelerated at the associated CME-driven shock. Our study may be important to understand certain extreme SEP events

  15. Event-related potentials, cognition, and behavior: a biological approach.

    Science.gov (United States)

    Kotchoubey, Boris

    2006-01-01

    The prevailing cognitive-psychological accounts of event-related brain potentials (ERPs) assume that ERP components manifest information processing operations leading from stimulus to response. Since this view encounters numerous difficulties already analyzed in previous studies, an alternative view is presented here that regards cortical control of behavior as a repetitive sensorimotor cycle consisting of two phases: (i) feedforward anticipation and (ii) feedback cortical performance. This view allows us to interpret in an integrative manner numerous data obtained from very different domains of ERP studies: from biophysics of ERP waves to their relationship to the processing of language, in which verbal behavior is viewed as likewise controlled by the same two basic control processes: feedforward (hypothesis building) and feedback (hypothesis checking). The proposed approach is intentionally simplified, explaining numerous effects on the basis of few assumptions and relating several levels of analysis: neurophysiology, macroelectrical processes (i.e. ERPs), cognition and behavior. It can, therefore, be regarded as a first approximation to a general theory of ERPs.

  16. Thermal release behavior of helium from copper irradiated by He+ ions

    International Nuclear Information System (INIS)

    Yamauchi, T.; Tokura, S.; Yamanaka, S.; Miyake, M.

    1988-01-01

    Thermal release behavior of helium from copper irradiated by 20 keV He + ions with a dose of 2x10 15 to 3x10 17 ions/cm 2 has been studied. The shape of the thermal release curves and thew number of helium release peaks strongly depend on the irradiation dose. Results from SEM surface observastion after post-irradiation heating suggested that helium release caused various surface damages such as blistering, flaking, and hole formation. Helium release resulting in small holes was analyzed and helium bubble growth mechanisms are discussed. (orig.)

  17. Effect of surface water on tritium release behavior from Li4SiO4

    International Nuclear Information System (INIS)

    Hanada, T.; Fukada, S.; Nishikawa, M.; Suematsu, K.; Yamashita, N.; Kanazawa, T.

    2010-01-01

    The tritium release model to represent the release behavior of bred tritium from solid breeder materials has been developed by the blanket group of Kyushu University. It has been found that water is released to the purge gas from solid breeder materials and that this water affects the tritium release behavior. In this study, the amount of surface water released from Li 4 SiO 4 is quantified by the experiment. In addition, the tritium release behavior from Li 4 SiO 4 are estimated based on the tritium release model using parameters obtained in our studies under conditions of commercial reactor operation and ITER test blanket module operation. The effect of the surface water on tritium release behavior is discussed from the obtained results. Moreover, the tritium inventory of Li 4 SiO 4 is discussed based on calculation under the unsteady state condition. Further, the effects of grain size and temperature on distribution of tritium inventory under the steady state condition are evaluated, and the optimal grain size is discussed from the view point of tritium release from Li 4 SiO 4 .

  18. Early Decrease in Respiration and Uncoupling Event Independent of Cytochrome c Release in PC12 Cells Undergoing Apoptosis

    Science.gov (United States)

    Berghella, Libera; Ferraro, Elisabetta

    2012-01-01

    Cytochrome c is a key molecule in mitochondria-mediated apoptosis. It also plays a pivotal role in cell respiration. The switch between these two functions occurs at the moment of its release from mitochondria. This process is therefore extremely relevant for the fate of the cell. Since cytochrome c mediates respiration, we studied the changes in respiratory chain activity during the early stages of apoptosis in order to contribute to unravel the mechanisms of cytochrome c release. We found that, during staurosporine (STS)- induced apoptosis in PC12 cells, respiration is affected before the release of cytochrome c, as shown by a decrease in the endogenous uncoupled respiration and an uncoupling event, both occurring independently of cytochrome c release. The decline in the uncoupled respiration occurs also upon Bcl-2 overexpression (which inhibits cytochrome c release), while the uncoupling event is inhibited by Bcl-2. We also observed that the first stage of nuclear condensation during STS-induced apoptosis does not depend on the release of cytochrome c into the cytosol and is a reversibile event. These findings may contribute to understand the mechanisms affecting mitochondria during the early stages of apoptosis and priming them for the release of apoptogenic factors. PMID:22666257

  19. Behavior of fission products released from severely damaged fuel during the PBF severe fuel damage tests

    International Nuclear Information System (INIS)

    Osetek, D.J.; Cronenberg, A.W.; Hagrman, D.L.; Broughton, J.M.; Rest, J.

    1984-01-01

    The results of fission product release behavior during the first two Power Burst Facility Severe Fuel Damage tests are presented. Measured fission product release is compared with calculated release using temperature dependent release rate correlations and FASTGRASS analysis. The test results indicate that release from fuel of the high volatility fission products (Xe, Kr, I, Cs, and Te) is strongly influenced by parameters other than fuel temperature; namely fuel/fission product morphology, fuel and cladding oxidation state, extent of fuel liquefaction, and quench induced fuel shattering. Fission product transport from the test fuel through the sample system was strongly influenced by chemical effects. Holdup of I and Cs was affected by fission product chemistry, and transport time while Te release was primarily influenced by the extent of zircaloy oxidation. Analysis demonstrates that such integral test data can be used to confirm physical, chemical, and mechanistic models of fission product behavior for severe accident conditions

  20. Modeling E. coli Release And Transport In A Creek During Artificial High-Flow Events

    Science.gov (United States)

    Yakirevich, A.; Pachepsky, Y. A.; Gish, T. J.; Cho, K.; Shelton, D. R.; Kuznetsov, M. Y.

    2012-12-01

    In-stream fate and transport of E. coli, is a leading indicator of microbial contamination of natural waters, and so needs to be understood to eventually minimize surface water contamination by microbial organisms. The objective of this work was to simulate E. coli release and transport from soil sediment in a creek bed both during and after high water flow events. The artificial high-water flow events were created by releasing 60-80 m3 of city water on a tarp-covered stream bank at a rate of 60 L/s in four equal allotments in July of 2008, 2009 and 2010. The small first-order creek used in this study is part of the Beaver Dam Creek Tributary and is located at the USDA Optimizing Production inputs for Economic and Environmental Enhancement (OPE3) research site, in Beltsville, Maryland. In 2009 and 2010 a conservative tracer difluorobenzoic acid (DFBA) was added to the released water. Specifically, water flow rates, E. coli and DFBA concentrations as well as water turbidity were monitored with automated samplers at the ends of the three in-stream weirs reaching a total length of 630 m. Sediment particle size distributions and the streambed E. coli concentrations were measured along a creek before and after experiment. The observed DFBA breakthrough curves (BTCs) exhibited long tails after the water pulse and tracer peaks indicating that transient storage might be an important element of the in-stream transport process. Turbidity and E. coli BTCs also exhibited long tails indicative of transient storage and low rates of settling caused by re-entrainment. Typically, turbidity peaked prior to E. coli and returned to lower base-line levels more rapidly. A one-dimensional model was applied to simulate water flow, E. coli and DFBA transport during these experiments. The Saint-Venant equations were used to calculate water depth and discharge while a stream solute transport model accounted for advection-dispersion, lateral inflow/outflow, exchange with the transient storage

  1. Reciprocal links between metabolic and ionic events in islet cells. Their relevance to the rhythmics of insulin release.

    Science.gov (United States)

    Malaisse, W J

    1998-02-01

    The notion of reciprocal links between metabolic and ionic events in islet cells and the rhythmics of insulin release is based on (i) the rhythmic pattern of hormonal release from isolated perfused rat pancreas, which supports the concept of an intrapancreatic pacemaker; (ii) the assumption that this phasic pattern is due to the integration of secretory activity in distinct functional units, e.g. distinct islets; and (iii) the fact that reciprocal coupling between metabolic and ionic events is operative in the secretory sequence.

  2. POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR

    Institute of Scientific and Technical Information of China (English)

    BEI Jianzhong; WANG Zhifeng; WANG Shenguo

    1995-01-01

    The drug release behavior of degradable polymer - polycaprolactone-poly (ethylene glycol)block copolymer(PCE) in vitro was investigated by using 5-Fluoro-uracil (5-Fu) as a model drug under a condition of pH 7.4 at 37℃. It is found that the release rate of 5-Fu from PCE increased with increasing polyether content of the copolymer. The results show that the increasing polyether content of the copolymer caused increasing hydrophilicity and decreasing crystallinity of the PCE copolymer. Thus, the drug release behavior and the degradable property of the PCE can be controlled by adjusting the composition of the copolymer.

  3. New oral dosage form for elderly patients. II. Release behavior of benfotiamine from silk fibroin gel.

    Science.gov (United States)

    Hanawa, T; Watanabe, A; Tsuchiya, T; Ikoma, R; Hidaka, M; Sugihara, M

    1995-05-01

    Silk fibroin gel (SFG) containing benfotiamine (BTMP) was prepared. The release behavior of BTMP from SFG was studied as a function of silk fibroin (SF) content and glycerol content, and the influence of the existence of beta-cyclodextrin (beta-CD) on the physicochemical properties of SFG were investigated. The release rate of BTMP from SFG was retarded by an increase in SF concentration. The addition of beta-CD affected both the release properties and rheological properties of the SFG. It was found from the results of the "paddle-bead method" that the release profiles of BTMP from SFG were inversely proportional to the SFG firmness.

  4. Effect of Permeation Enhancers on the Release Behavior and ...

    African Journals Online (AJOL)

    Purpose: The aim of this research work was to formulate, characterize and evaluate the in vitro permeation behavior of tramadol lotion containing propylene glycol (PG) and polyethylene glycol (PEG) as permeation enhancers. Methods: The permeation experiments were conducted in vitro using full thickness rabbit skin in ...

  5. Characterization of endocrine events during the periestrous period in sheep after estrous synchronization with controlled internal drug release (CIDR) device.

    Science.gov (United States)

    Van Cleeff, J; Karsch, F J; Padmanabhan, V

    1998-01-01

    The Controlled Internal Drug Releasing (CIDR) device is an intravaginal pessary containing progesterone (P4) designed for synchronizing estrus in ruminants. To date, there has been little information available on the timing, duration, and quality of the follicular phase after CIDR removal and how those characteristics compare with natural periovulatory endocrine events. The present communication relates the results of methods we used to characterize the endocrine events that followed CIDR synchronization. Breeding-season ewes were given an injection (10 mg) of Lutalyse (PGF2 alpha), and then studied during three consecutive estrous cycles, beginning in the luteal phase after the estrus induced by PGF2 alpha. Cycle 1 estrus was synchronized with 1 CIDR (Type G) inserted for 8 d beginning 10 d after PGF2 alpha. Cycles 2 and 3 were synchronized with two CIDRs for 8 d beginning 10 d after previous CIDR removal. Cycle 1 estrous behavior and serum gonadotropins showed a follicular phase (the interval from CIDR withdrawal to gonadotropin surge [surge] peak) of 38.2 +/- 1.5 hr. Two CIDRs lengthened the interval to 46.2 +/- 1.5 hr (P synchronization concentrated surges within a 24-hr period in 92% of the ewes in Cycles 1 and 2. Cycles 3 ewes were euthanized at estimated luteal, early follicular, late follicular, LH surge, and secondary FSH rise timepoints. Endocrine data and ovaries showed that 88% of the ewes synchronized with two CIDRs were in the predicted stage of the estrous cycle. These data demonstrate that the CIDR device applied during the luteal phase effectively synchronizes estrus and results in a CIDR removal-to-surge interval of similar length to a natural follicular phase.

  6. The release behavior and kinetic evaluation of tramadol HCl from chemically cross linked Ter polymeric hydrogels.

    Science.gov (United States)

    Malana, Muhammad A; Zohra, Rubab

    2013-01-18

    Hydrogels, being stimuli responsive are considered to be effective for targeted and sustained drug delivery. The main purpose for this work was to study the release behavior and kinetic evaluation of Tramadol HCl from chemically cross linked ter polymeric hydrogels. Ter-polymers of methacrylate, vinyl acetate and acrylic acid cross linked with ethylene glycol dimethacrylate (EGDMA) were prepared by free radical polymerization. The drug release rates, dynamic swelling behavior and pH sensitivity of hydrogels ranging in composition from 1-10 mol% EGDMA were studied. Tramadol HCl was used as model drug substance. The release behavior was investigated at pH 8 where all formulations exhibited non-Fickian diffusion mechanism. Absorbency was found to be more than 99% indicating good drug loading capability of these hydrogels towards the selected drug substance. Formulations designed with increasing amounts of EGDMA had a decreased equilibrium media content as well as media penetrating velocity and thus exhibited a slower drug release rate. Fitting of release data to different kinetic models indicate that the kinetic order shifts from the first to zero order as the concentration of drug was increased in the medium, showing gradual independency of drug release towards its concentration. Formulations with low drug content showed best fitness with Higuchi model whereas those with higher concentration of drug followed Hixson-Crowell model with better correlation values indicating that the drug release from these formulations depends more on change in surface area and diameter of tablets than that on concentration of the drug. Release exponent (n) derived from Korse-Meyer Peppas equation implied that the release of Tramadol HCl from these formulations was generally non-Fickian (n > 0.5 > 1) showing swelling controlled mechanism. The mechanical strength and controlled release capability of the systems indicate that these co-polymeric hydrogels have a great potential to

  7. Effects of Vascular and Nonvascular Adverse Events and of Extended-Release Niacin With Laropiprant on Health and Healthcare Costs.

    Science.gov (United States)

    Kent, Seamus; Haynes, Richard; Hopewell, Jemma C; Parish, Sarah; Gray, Alastair; Landray, Martin J; Collins, Rory; Armitage, Jane; Mihaylova, Borislava

    2016-07-01

    Extended-release niacin with laropiprant did not significantly reduce the risk of major vascular events and increased the risk of serious adverse events in Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE), but its net effects on health and healthcare costs are unknown. 25 673 participants aged 50 to 80 years with previous cardiovascular disease were randomized to 2 g of extended-release niacin with 40 mg of laropiprant daily versus matching placebo, in addition to effective statin-based low-density lipoprotein cholesterol-lowering treatment. The net effects of niacin-laropiprant on quality-adjusted life years and hospital care costs (2012 UK £; converted into US $ using purchasing power parity index) during 4 years in HPS2-THRIVE were evaluated using estimates of the impact of serious adverse events on health-related quality of life and hospital care costs. During the study, participants assigned niacin-laropiprant experienced marginally but not statistically significantly lower survival (0.012 fewer years [standard error (SE) 0.007]), fewer quality-adjusted life years (0.023 [SE 0.007] fewer using UK EQ-5D scores; 0.020 [SE 0.006] fewer using US EQ-5D scores) and accrued greater hospital costs (UK £101 [SE £37]; US $145 [SE $53]). Stroke, heart failure, musculoskeletal events, gastrointestinal events, and infections were associated with significant decreases in health-related quality of life in both the year of the event and in subsequent years. All serious vascular and nonvascular events were associated with substantial increases in hospital care costs. In HPS2-THRIVE, the addition of extended-release niacin-laropiprant to statin-based therapy reduced quality of life-adjusted survival and increased hospital costs. URL: http://clinicaltrials.gov. Unique identifier: NCT00461630. © 2016 American Heart Association, Inc.

  8. Behavioral and Physiological Responses of Calves to Marshalling and Roping in a Simulated Rodeo Event

    Directory of Open Access Journals (Sweden)

    Michelle Sinclair

    2016-04-01

    Full Text Available Rodeos are public events at which stockpeople face tests of their ability to manage cattle and horses, some of which relate directly to rangeland cattle husbandry. One of these is calf roping, in which a calf released from a chute is pursued by a horse and rider, who lassoes, lifts and drops the calf to the ground and finally ties it around the legs. Measurements were made of behavior and stress responses of ten rodeo-naïve calves marshalled by a horse and rider, and ten rodeo-experienced calves that were roped. Naïve calves marshalled by a horse and rider traversed the arena slowly, whereas rodeo-experienced calves ran rapidly until roped. Each activity was repeated once after two hours. Blood samples taken before and after each activity demonstrated increased cortisol, epinephrine and nor-epinephrine in both groups. However, there was no evidence of a continued increase in stress hormones in either group by the start of the repeated activity, suggesting that the elevated stress hormones were not a response to a prolonged effect of the initial blood sampling. It is concluded that both the marshalling of calves naïve to the roping chute by stockpeople and the roping and dropping of experienced calves are stressful in a simulated rodeo calf roping event.

  9. Dynamic Duos? Jamaican Fruit Bats (Artibeus jamaicensis Do Not Show Prosocial Behavior in a Release Paradigm

    Directory of Open Access Journals (Sweden)

    Eric Hoffmaster

    2016-11-01

    Full Text Available Once thought to be uniquely human, prosocial behavior has been observed in a number of species, including vampire bats that engage in costly food-sharing. Another social chiropteran, Jamaican fruit bats (Artibeus jamaicensis, have been observed to engage in cooperative mate guarding, and thus might be expected to display prosocial behavior as well. However, frugivory and hematophagy diets may impose different selection pressures on prosocial preferences, given that prosocial preferences may depend upon cognitive abilities selected by different ecological constraints. Thus, we assessed whether Jamaican fruit bats would assist a conspecific in an escape paradigm in which a donor could opt to release a recipient from an enclosure. The test apparatus contained two compartments—one of which was equipped with a sensor that, once triggered, released the trap door of the adjacent compartment. Sixty-six exhaustive pairs of 12 bats were tested, with each bat in each role, twice when the recipient was present and twice when absent. Bats decreased their behavior of releasing the trapdoor in both conditions over time, decreasing the behavior slightly more rapidly in the recipient absent condition. Bats did not release the door more often when recipients were present, regardless of the recipient; thus, there was no clear evidence of prosocial behavior.

  10. Visualization of Sedentary Behavior Using an Event-Based Approach

    Science.gov (United States)

    Loudon, David; Granat, Malcolm H.

    2015-01-01

    Visualization is commonly used in the interpretation of physical behavior (PB) data, either in conjunction with or as precursor to formal analysis. Effective representations of the data can enable the identification of patterns of behavior, and how they relate to the temporal context in a single day, or across multiple days. An understanding of…

  11. Gas retention and release behavior in Hanford single-shell waste tanks

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, C.W.; Brewster, M.E.; Gauglitz, P.A.; Mahoney, L.A.; Meyer, P.A.; Recknagle, K.P.; Reid, H.C.

    1996-12-01

    This report describes the current understanding of flammable gas retention and release in Hanford single-shell waste tanks based on theory, experimental results, and observations of tank behavior. The single-shell tanks likely to pose a flammable gas hazard are listed and described, and photographs of core extrusions and the waste surface are included. The credible mechanisms for significant flammable gas releases are described, and release volumes and rates are quantified as much as possible. The only mechanism demonstrably capable of producing large ({approximately}100 m{sup 3}) spontaneous gas releases is the buoyant displacement, which occurs only in tanks with a relatively deep layer of supernatant liquid. Only the double-shell tanks currently satisfy this condition. All release mechanisms believed plausible in single-shell tanks have been investigated, and none have the potential for large spontaneous gas releases. Only small spontaneous gas releases of several cubic meters are likely by these mechanisms. The reasons several other postulated gas release mechanisms are implausible or incredible are also given.

  12. Gas retention and release behavior in Hanford single-shell waste tanks

    International Nuclear Information System (INIS)

    Stewart, C.W.; Brewster, M.E.; Gauglitz, P.A.; Mahoney, L.A.; Meyer, P.A.; Recknagle, K.P.; Reid, H.C.

    1996-12-01

    This report describes the current understanding of flammable gas retention and release in Hanford single-shell waste tanks based on theory, experimental results, and observations of tank behavior. The single-shell tanks likely to pose a flammable gas hazard are listed and described, and photographs of core extrusions and the waste surface are included. The credible mechanisms for significant flammable gas releases are described, and release volumes and rates are quantified as much as possible. The only mechanism demonstrably capable of producing large (∼100 m 3 ) spontaneous gas releases is the buoyant displacement, which occurs only in tanks with a relatively deep layer of supernatant liquid. Only the double-shell tanks currently satisfy this condition. All release mechanisms believed plausible in single-shell tanks have been investigated, and none have the potential for large spontaneous gas releases. Only small spontaneous gas releases of several cubic meters are likely by these mechanisms. The reasons several other postulated gas release mechanisms are implausible or incredible are also given

  13. Event-governed and verbally-governed behavior

    OpenAIRE

    Vargas, Ernest A.

    1988-01-01

    A number of statements prescribe behavior: apothegms, maxims, proverbs, instructions, and so on. These differing guides to conduct present varieties of the dictionary definition of “rules.” The term “rules” thus defines a category of language usage. Such a term, and its derivative, “rule-governed,” does not address a controlling relation in the analysis of verbal behavior. The prevailing confounding of a category of language with a category of verbal behavior appears related to a lack of unde...

  14. Natural and industrial analogues for release of CO2 from storagereservoirs: Identification of features, events, and processes and lessonslearned

    Energy Technology Data Exchange (ETDEWEB)

    Lewicki, Jennifer L.; Birkholzer, Jens; Tsang, Chin-Fu

    2006-03-03

    The injection and storage of anthropogenic CO{sub 2} in deep geologic formations is a potentially feasible strategy to reduce CO{sub 2} emissions and atmospheric concentrations. While the purpose of geologic carbon storage is to trap CO{sub 2} underground, CO{sub 2} could migrate away from the storage site into the shallow subsurface and atmosphere if permeable pathways such as well bores or faults are present. Large-magnitude releases of CO{sub 2} have occurred naturally from geologic reservoirs in numerous volcanic, geothermal, and sedimentary basin settings. Carbon dioxide and natural gas have also been released from geologic CO{sub 2} reservoirs and natural gas storage facilities, respectively, due to influences such as well defects and injection/withdrawal processes. These systems serve as natural and industrial analogues for the potential release of CO{sub 2} from geologic storage reservoirs and provide important information about the key features, events, and processes (FEPs) that are associated with releases, as well as the health, safety, and environmental consequences of releases and mitigation efforts that can be applied. We describe a range of natural releases of CO{sub 2} and industrial releases of CO{sub 2} and natural gas in the context of these characteristics. Based on this analysis, several key conclusions can be drawn, and lessons can be learned for geologic carbon storage. First, CO{sub 2} can both accumulate beneath, and be released from, primary and secondary reservoirs with capping units located at a wide range of depths. Both primary and secondary reservoir entrapments for CO{sub 2} should therefore be well characterized at storage sites. Second, many natural releases of CO{sub 2} have been correlated with a specific event that triggered the release, such as magmatic fluid intrusion or seismic activity. The potential for processes that could cause geomechanical damage to sealing cap rocks and trigger the release of CO{sub 2} from a storage

  15. Gas retention and release behavior in Hanford double-shell waste tanks

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, P.A.; Brewster, M.E.; Bryan, S.A. [and others

    1997-05-01

    This report describes the current understanding of flammable gas retention and release in Hanford double-shell waste tanks AN-103, AN-104, AN-105, AW-101, SY-101, and SY-103. This knowledge is based on analyses, experimental results, and observations of tank behavior. The applicable data available from the void fraction instrument, retained gas sampler, ball rheometer, tank characterization, and field monitoring are summarized. Retained gas volumes and void fractions are updated with these new data. Using the retained gas compositions from the retained gas sampler, peak dome pressures during a gas burn are calculated as a function of the fraction of retained gas hypothetically released instantaneously into the tank head space. Models and criteria are given for gas generation, initiation of buoyant displacement, and resulting gas release; and predictions are compared with observed tank behavior.

  16. Gas retention and release behavior in Hanford double-shell waste tanks

    International Nuclear Information System (INIS)

    Meyer, P.A.; Brewster, M.E.; Bryan, S.A.

    1997-05-01

    This report describes the current understanding of flammable gas retention and release in Hanford double-shell waste tanks AN-103, AN-104, AN-105, AW-101, SY-101, and SY-103. This knowledge is based on analyses, experimental results, and observations of tank behavior. The applicable data available from the void fraction instrument, retained gas sampler, ball rheometer, tank characterization, and field monitoring are summarized. Retained gas volumes and void fractions are updated with these new data. Using the retained gas compositions from the retained gas sampler, peak dome pressures during a gas burn are calculated as a function of the fraction of retained gas hypothetically released instantaneously into the tank head space. Models and criteria are given for gas generation, initiation of buoyant displacement, and resulting gas release; and predictions are compared with observed tank behavior

  17. Turbid releases from Glen Canyon Dam, Arizona, following rainfall-runoff events of September 2013

    Science.gov (United States)

    Wildman, Richard A.; Vernieu, William

    2017-01-01

    Glen Canyon Dam is a large dam on the Colorado River in Arizona. In September 2013, it released turbid water following intense thunderstorms in the surrounding area. Turbidity was >15 nephelometric turbidity units (NTU) for multiple days and >30 NTU at its peak. These unprecedented turbid releases impaired downstream fishing activity and motivated a rapid-response field excursion. At 5 locations upstream from the dam, temperature, specific conductance, dissolved oxygen, chlorophyll a, and turbidity were measured in vertical profiles. Local streamflow and rainfall records were retrieved, and turbidity and specific conductance data in dam releases were evaluated. Profiling was conducted to determine possible sources of turbidity from 3 tributaries nearest the dam, Navajo, Antelope, and Wahweap creeks, which entered Lake Powell as interflows during this study. We discuss 4 key conditions that must have been met for tributaries to influence turbidity of dam releases: tributary flows must have reached the dam, tributary flows must have been laden with sediment, inflow currents must have been near the depth of dam withdrawals, and the settling velocity of particles must have been slow. We isolate 2 key uncertainties that reservoir managers should resolve in future similar studies: the reach of tributary water into the reservoir thalweg and the distribution of particle size of suspended sediment. These uncertainties leave the source of the turbidity ambiguous, although an important role for Wahweap Creek is possible. The unique combination of limnological factors we describe implies that turbid releases at Glen Canyon Dam will continue to be rare.

  18. The current status of ARAC [Atmospheric Release Advisory Capability] and its application to the Chernobyl event

    International Nuclear Information System (INIS)

    Gudiksen, P.H.; Sullivan, T.J.; Harvey, T.F.

    1986-10-01

    The Atmospheric Release Advisory Capability (ARAC) project, developed by the Lawrence Livermore National Laboratory (LLNL), provides real-time dose assessments and estimates of the extent of surface contamination that may result from an atmospheric release of radioactivity. It utilizes advanced computer-based data communication and processing systems to acquire the meteorological and source term information needed by the three-dimensional atmospheric dispersion models to derive the consequence assessments. The ARAC responded to the recent Chernobyl reactor accident in the Soviet Union by estimating the source term and the radiation dose distribution due to exposure to the radioactive cloud over Europe and the Northern Hemisphere. This analysis revealed that approximately 50% of the estimated core inventories of I-131 and Cs-137 were released. The estimated committed effective dose equivalent due to inhalation of radioactivty during cloud passage is of the order of 10 mrem within parts of Scandinavia and eastern Europe, while most of the populations within central Europe were exposed to levels ranging from 1 to 10 mrem. The amount of Cs-137 released by the Chernobyl accident far exceeds that released by previous reactor accidents, but is only about 6% of the Cs-137 produced by the atmospheric weapon testing programs. 9 refs., 4 figs., 2 tabs

  19. Fabrication, characterization and in vitro drug release behavior of electrospun PLGA/chitosan nanofibrous scaffold

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Z.X.; Zheng, W.; Li, L. [Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001 (China); Zheng, Y.F., E-mail: yfzheng@pku.edu.cn [Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001 (China); Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871 (China)

    2011-02-15

    Graphical abstract: The fenbufen loaded PLGA/chitosan nanofibrous scaffolds were fabricated by electrospinning. The hydrophilicity of nanofibrous scaffold was enhanced with the increase of chitosan content. The drug release also is accelerated with chitosan increasing because the higher hydrophilicity makes drug diffusing from scaffold more easily. Research highlights: {yields} The average diameter increased with the increase of chitosan content and then decreased. {yields} The release rate of fenbufen increased with the increase of chitosan. {yields} The aligned nanofibrous scaffold exhibits lower drug release rate. {yields} The drug release could be controlled by crosslinking in glutaraldehyde vapor. - Abstract: In this study both aligned and randomly oriented poly(D,L-lactide-co-glycolide) (PLGA)/chitosan nanofibrous scaffold have been prepared by electrospinning. The ratio of PLGA to chitosan was adjusted to get smooth nanofiber surface. Morphological characterization using scanning electron microscopy showed that the aligned nanofiber diameter distribution obtained by electrospinning of polymer blend increased with the increase of chitosan content which was similar to that of randomly oriented nanofibers. The release characteristic of model drug fenbufen (FBF) from the FBF-loaded aligned and randomly oriented PLGA and PLGA/chitosan nanofibrous scaffolds was investigated. The drug release rate increased with the increase of chitosan content because the addition of chitosan enhanced the hydrophilicity of the PLGA/chitosan composite scaffold. Moreover, for the aligned PLGA/chitosan nanofibrous scaffold the release rate was lower than that of randomly oriented PLGA/chitosan nanofibrous scaffold, which indicated that the nanofiber arrangement would influence the release behavior. In addition, crosslinking in glutaraldehyde vapor would decrease the burst release of FBF from FBF-loaded PLGA/chitosan nanofibrous scaffold with a PLGA/chitosan ratio less than 9/1, which

  20. Fabrication, characterization and in vitro drug release behavior of electrospun PLGA/chitosan nanofibrous scaffold

    International Nuclear Information System (INIS)

    Meng, Z.X.; Zheng, W.; Li, L.; Zheng, Y.F.

    2011-01-01

    Graphical abstract: The fenbufen loaded PLGA/chitosan nanofibrous scaffolds were fabricated by electrospinning. The hydrophilicity of nanofibrous scaffold was enhanced with the increase of chitosan content. The drug release also is accelerated with chitosan increasing because the higher hydrophilicity makes drug diffusing from scaffold more easily. Research highlights: → The average diameter increased with the increase of chitosan content and then decreased. → The release rate of fenbufen increased with the increase of chitosan. → The aligned nanofibrous scaffold exhibits lower drug release rate. → The drug release could be controlled by crosslinking in glutaraldehyde vapor. - Abstract: In this study both aligned and randomly oriented poly(D,L-lactide-co-glycolide) (PLGA)/chitosan nanofibrous scaffold have been prepared by electrospinning. The ratio of PLGA to chitosan was adjusted to get smooth nanofiber surface. Morphological characterization using scanning electron microscopy showed that the aligned nanofiber diameter distribution obtained by electrospinning of polymer blend increased with the increase of chitosan content which was similar to that of randomly oriented nanofibers. The release characteristic of model drug fenbufen (FBF) from the FBF-loaded aligned and randomly oriented PLGA and PLGA/chitosan nanofibrous scaffolds was investigated. The drug release rate increased with the increase of chitosan content because the addition of chitosan enhanced the hydrophilicity of the PLGA/chitosan composite scaffold. Moreover, for the aligned PLGA/chitosan nanofibrous scaffold the release rate was lower than that of randomly oriented PLGA/chitosan nanofibrous scaffold, which indicated that the nanofiber arrangement would influence the release behavior. In addition, crosslinking in glutaraldehyde vapor would decrease the burst release of FBF from FBF-loaded PLGA/chitosan nanofibrous scaffold with a PLGA/chitosan ratio less than 9/1, which would be beneficial

  1. Physicochemical properties and drug release behavior of biguanidino and O-carboxymethyl chitosan microcapsules.

    Science.gov (United States)

    Huo, Weiqiang; Zhang, Weixin; Wang, Wei; Zhou, Xiaohua

    2014-09-01

    Two types of microcapsules (MCs) were prepared by the emulsion cross-linking method, where biguanidino chitosan (BGCS)and O-carboxymethyl chitosan (O-CMCS) served as the wall materials, and the antibacterial agent 2,4-diamino-6-(2-pyridyl)-1,3,5-triazine (PyTNH) served as a model water-soluble drug. The physicochemical performance of the MCs and their drug release behavior were investigated by Fourier transform infrared spectroscopy, thermogravimetric analysis/derivative thermogravimetric analysis, scanning electron microscopy, and swelling and in vitro drug release studies of the two MCs with unmodified chitosan-MCs (CS-MCs) used as the control. The results indicated that the degree of cross-linking, encapsulation efficiency, and thermal stability of the shell wall of the BGCS-microcapsules (BGCS-MCs) were much higher than those of the control and the O-CMCS-microcapsules (CMCS-MCs), owing to the reduction of steric hindrance and development of the conjugation effect in the cross-linking process. Studies on the swelling and in vitro drug-release behavior revealed a sustained release effect of the BGCS-MCs. Moreover, the CMCS-MCs were found to exhibit a pH-dependent drug release behavior, which can be attributed to the successive formation of H-bonds and repulsive forces with the change in the pH of the medium. Based on these results, the swelling-release models and the drug release kinetics of BGCS-MCs and CMCS-MCs are proposed. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Climate Change : Behavioral Responses from Extreme Events and Delayed Damages

    NARCIS (Netherlands)

    Ghidoni, Riccardo; Calzolari, G.; Casari, Marco

    2017-01-01

    Understanding how to sustain cooperation in the climate change global dilemma is crucial to mitigate its harmful consequences. Damages from climate change typically occurs after long delays and can take the form of more frequent realizations of extreme and random events. These features generate a

  3. Climate change : Behavioral responses from extreme events and delayed damages

    NARCIS (Netherlands)

    Ghidoni, Riccardo; Calzolari, Giacomo; Casari, Marco

    2017-01-01

    Understanding how to sustain cooperation in the climate change global dilemma is crucial to mitigate its harmful consequences. Damages from climate change typically occur after long delays and can take the form of more frequent realizations of extreme and random events. These features generate a

  4. Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling.

    Science.gov (United States)

    Campiñez, María Dolores; Caraballo, Isidoro; Puchkov, Maxim; Kuentz, Martin

    2017-07-01

    The aim of the present work was to better understand the drug-release mechanism from sustained release matrices prepared with two new polyurethanes, using a novel in silico formulation tool based on 3-dimensional cellular automata. For this purpose, two polymers and theophylline as model drug were used to prepare binary matrix tablets. Each formulation was simulated in silico, and its release behavior was compared to the experimental drug release profiles. Furthermore, the polymer distributions in the tablets were imaged by scanning electron microscopy (SEM) and the changes produced by the tortuosity were quantified and verified using experimental data. The obtained results showed that the polymers exhibited a surprisingly high ability for controlling drug release at low excipient concentrations (only 10% w/w of excipient controlled the release of drug during almost 8 h). The mesoscopic in silico model helped to reveal how the novel biopolymers were controlling drug release. The mechanism was found to be a special geometrical arrangement of the excipient particles, creating an almost continuous barrier surrounding the drug in a very effective way, comparable to lipid or waxy excipients but with the advantages of a much higher compactability, stability, and absence of excipient polymorphism.

  5. Protecting marine parks and sanctuaries from aquatic nuisance species releases from ballast during emergency response events

    Science.gov (United States)

    Phyllis A. Green

    2011-01-01

    Commercial shipping activities that release aquatic invasive species are recognized globally as a dominant transport vector for marine invasions. Aquatic nuisance species (ANS) introductions have resulted in billions of dollars of damages and immeasurable biological devastation within the Great Lakes. National Park Service managers are working with United States...

  6. Life events, locus of control, and behavioral problems among Chinese adolescents.

    Science.gov (United States)

    Liu, X; Kurita, H; Uchiyama, M; Okawa, M; Liu, L; Ma, D

    2000-12-01

    This study examined associations of life events and locus of control with behavioral problems among 1,365 Chinese adolescents by using the Youth Self-Report (YSR), Adolescent Self-Rating Life Events Checklist (ASLEC), and the Nowicki-Strickland Locus of Control Scale for Children. Results indicated that the overall prevalence of behavioral and emotional problems was 10.7% (95% CI = 9.9-11.5%). Logistic-regression analyses showed that a total of 13 negative life events mainly coming from academic domain and interpersonal relationships, high life-stress score, and high external locus score significantly increased the risk for behavioral problems. Life stress and locus of control significantly interacted with behavioral problems. These findings support the linkage between stressful life events and psychopathology in a general population of adolescents from mainland China, and demonstrate the stress-moderating effects of locus of control on psychopathology as well.

  7. Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

    Directory of Open Access Journals (Sweden)

    Kazuyuki Takata

    2017-10-01

    Full Text Available We investigated the release behavior of glucagon-like peptide-1 (GLP-1 from a biodegradable injectable polymer (IP hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40 was observed compared with a reversible (physical gelation IP formulation (F(P1. Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.

  8. Fluoride release and recharge behavior of a nano-filled resin-modified glass ionomer compared with that of other fluoride releasing materials.

    Science.gov (United States)

    Mitra, Sumita B; Oxman, Joe D; Falsafi, Afshin; Ton, Tiffany T

    2011-12-01

    To compare the long-term fluoride release kinetics of a novel nano-filled two-paste resin-modified glass-ionomer (RMGI), Ketac Nano (KN) with that of two powder-liquid resin-modified glass-ionomers, Fuji II LC (FLC) and Vitremer (VT) and one conventional glass-ionomer, Fuji IX (FIX). Fluoride release was measured in vitro using ion-selective electrodes. Kinetic analysis was done using regression analysis and compared with existing models for GIs and compomers. In a separate experiment the samples of KN and two conventional glass-ionomers, FIX and Ketac Molar (KM) were subjected to a treatment with external fluoride source (Oral-B Neutra-Foam) after 3 months of fluoride release and the recharge behavior studied for an additional 7-day period. The cumulative amount of fluoride released from KN, VT and FLC and the release profiles were statistically similar but greater than that for FIX at P coating of KN with its primer and of DY with its adhesive did not significantly alter the fluoride release behavior of the respective materials. The overall rate for KN was significantly higher than for the compomer DY. DY showed a linear rate of release vs. t and no burst effect as expected for compomers. The nanoionomer KN showed fluoride recharge behavior similar to the conventional glass ionomers FIX and KM. Thus, it was concluded that the new RMGI KN exhibits fluoride ion release behavior similar to typical conventional and RMGIs and that the primer does not impede the release of fluoride.

  9. Corticotropine-releasing hormone and/or corticosterone differentially affect behavior of rat

    Czech Academy of Sciences Publication Activity Database

    Valeš, Karel; Řezáčová, Lenka; Stuchlík, Aleš

    2008-01-01

    Roč. 11, Suppl.1 (2008), s. 118-118 ISSN 1461-1457. [CINP Congress /26./. 13.07.2008-17.07.2008, Munich] R&D Projects: GA MŠk(CZ) 1M0517; GA MZd NR9180; GA ČR(CZ) GA309/07/0341 Institutional research plan: CEZ:AV0Z50110509 Keywords : cpo1 * corticotropine-releasing hormone * corticosterone * behavior Subject RIV: FH - Neurology

  10. Parental Separation and Child Aggressive and Internalizing Behavior: An Event History Calendar Analysis

    Science.gov (United States)

    Averdijk, Margit; Malti, Tina; Eisner, Manuel; Ribeaud, Denis

    2012-01-01

    This study investigated the relationship between parental separation and aggressive and internalizing behavior in a large sample of Swiss children drawn from the ongoing Zurich Project on the Social Development of Children and Youths. Parents retrospectively reported life events and problem behavior for the first 7 years of the child's life on a…

  11. Metal release behavior of surface oxidized stainless steels into flowing high temperature pure water

    International Nuclear Information System (INIS)

    Fujiwara, Kazuo; Tomari, Haruo; Nakayama, Takenori; Shimogori, Kazutoshi; Ishigure, Kenkichi; Matsuura, Chihiro; Fujita, Norihiko; Ono, Shoichi.

    1987-01-01

    In order to clarify the effect of oxidation treatment of Type 304 SS on the inhibition of metal release into high temperature pure water, metal release rate of individual alloying element into flowing deionized water containing 50 ppb dissolved oxygen was measured as the function of exposure time on representative specimens oxidized in air and steam. The behavior of metal release was also discussed in relation to the structure of surface films. Among the alloying elements the amount of Fe ion, Cr ion and Fe crud in high temperature pure water tended to saturate with the exposure time and that of Ni ion and Co ion tended to increase monotonously with the exposure time for all specimens tested. And the treatment of steam-oxidation was the most effective to decrease the metal release of alloying elements and the treatment by air-oxidation also decreased the metal release. These tendencies were confirmed to correlate well with the structure of the surface films as it was in the results in the static autoclave test. (author)

  12. Concurrent duodenal manometric and impedance recording to evaluate the effects of hyoscine on motility and flow events, glucose absorption, and incretin release

    NARCIS (Netherlands)

    Chaikomin, Reawika; Wu, Keng Liang; Doran, Selena; Jones, Karen L.; Smout, Andre J. P. M.; Renooij, Willem; Holloway, Richard H.; Meyer, James H.; Horowitz, Michael; Rayner, Christopher K.

    2007-01-01

    Upper gastrointestinal motor function and incretin hormone secretion are major determinants of postprandial glycemia and insulinemia. However, the impact of small intestinal flow events on glucose absorption and incretin release is poorly defined. Intraluminal impedance monitoring is a novel

  13. A Status of Art-Report on the Fission Products Behavior Released from Spent Fuel at High Temperature Conditions

    International Nuclear Information System (INIS)

    Park, Geun Il; Kim, J. H.; Lee, J. W.

    2003-04-01

    The experiments on the fission products release behavior from spent fuel at high temperature assuming reactor accident conditions have been carried out at Oak Ridge Nation Laboratory of USA in HI/VI tests, CEA of France in HEVA/VERCOS tests, AEA of England and CRNL of Canada in HOX test. The VEGA program to study the fission product release behavior from LWR irradiated fuel was recently initiated at JAERI. The key parameter affecting the fission product(FP) release behavior is temperature. In addition, other parameters such as fuel oxidation, burnup, pre-transient conditions are found to affect the FP releases considerably in the earlier tests. The atmosphere conditions such as oxidizing atmosphere (steam or air) or reducing atmosphere (hydrogen) can cause significant change of FPs release and transport behavior due to chemical forms of the reactive FPs which is dependent on the oxidation potential. The effect of fuel burnup on the Kr-85 or Cs-137 release showed that the release rates of these radionuclides increased with the increase of burnup, meaning that release rates are dominated by the atomic diffusions in the grains and they are primarily a function of temperature. However, the data on FPs release behavior using higher burnups above 50,000 MWD/MTU are not so many reported up to now. This report summarizes the test results of FPs release behavior in reactor accident conditions produced from other countries mentioned above. This review and analysis on earlier studies would be useful for predicting the release characteristics of FPs from domestic spent fuel. The release rates of fission gas or FPs from spent fuel at high temperature conditions during fabrication process of dry recycling fuel were also analyzed using many data obtained from earlier tests

  14. Association between adverse life events and addictive behaviors among male and female adolescents.

    Science.gov (United States)

    Lee, Grace P; Storr, Carla L; Ialongo, Nicholas S; Martins, Silvia S

    2012-01-01

    Adverse life events have been associated with gambling and substance use as they can serve as forms of escapism. Involvement in gambling and substance use can also place individuals in adversely stressful situations. To explore potential male-female differences in the association between addictive behavior and adverse life events among an urban cohort of adolescents. The study sample comprised of 515 adolescent participants in a randomized prevention trial. With self-reported data, four addictive behavior groups were created: nonsubstance users and nongamblers, substance users only, gamblers only, and substance users and gamblers. Multinomial logistic regression analyses with interaction terms of sex and adverse life events were conducted. Adverse life events and engaging in at least one addictive behavior were common for both sexes. Substance users and gamblers had more than twice the likelihood of nonsubstance users and nongamblers to experience any event as well as events of various domains (ie, relationship, violence, and instability). Neither relationship nor instability events' associations with the co-occurrence of substance use and gambling significantly differed between sexes. Conversely, females exposed to violence events were significantly more likely than similarly exposed males to report the co-occurrence of substance use and gambling. Findings from the current study prompt future studies to devote more attention to the development of effective programs that teach adaptive coping strategies to adolescents, particularly to females upon exposure to violence. Copyright © American Academy of Addiction Psychiatry.

  15. Assessment of models for steam release from concrete and implications for modeling corium behavior in reactor cavities

    International Nuclear Information System (INIS)

    Washington, K.E.; Carroll, D.E.

    1988-01-01

    Models for concrete outgassing have been developed and incorporated into a developmental version of the CONTAIN code for the assessment of corium behavior in reactor cavities. The resultant code, referred to as CONTAIN/OR in order to distinguish it from the released version of CONTAIN, has the capability to model transient heat conduction and concrete outgassing in core-concrete interaction problems. This study focused on validation and assessment of the outgassing model through comparisons with other concrete response codes. In general, the model is not mechanistic; however, there are certain important processes and feedback effects that are treated rigorously. The CONTAIN outgassing model was compared against two mechanistic concrete response codes (USINT and SLAM). Gas release and temperature profile predictions for several concrete thicknesses and heating rates were performed with acceptable agreement seen in each case. The model was also applied to predict corium behavior in a reactor cavity for a hypothetical severe accident scenario. In this calculation, gases evolving from the concrete during nonablating periods fueled exothermic Zr chemical reactions in the corium. Higher corium temperatures and more concrete ablation were observed when compared with that seen when concrete outgassing was neglected. Even though this result depends somewhat upon the makeup of the corium sources and the concrete type in the cavity, it does show that concrete outgassing can be important in the modeling of corium behavior in reactor cavities. In particular, the need to expand the traditional role of CORCON from steady-state ablation to the consideration of more transient events is clearly evident as a result of this work. 5 refs., 11 figs., 1 tab

  16. Modelling of fission product release behavior from HTR spherical fuel elements under accident conditions

    International Nuclear Information System (INIS)

    Verfondern, K.; Mueller, D.

    1991-01-01

    Computer codes for modelling the fission product release behavior of spherical fuel elements for High Temperature Reactors (HTR) have been developed for the purpose of being used in risk analyses for HTRs. An important part of the validation and verification procedure for these calculation models is the theoretical investigation of accident simulation experiments which have been conducted in the KueFA test facility in the Hot Cells at KFA. The paper gives a presentation of the basic modeling and the calculational results of fission product release from modern German HTR fuel elements in the temperature range 1600-1800 deg. C using the TRISO coated particle failure model PANAMA and the diffusion model FRESCO. Measurements of the transient release behavior for cesium and strontium and of their concentration profiles after heating have provided informations about diffusion data in the important retention barriers of the fuel: silicon carbide and matrix graphite. It could be shown that the diffusion coefficients of both cesium and strontium in silicon carbide can significantly be reduced using a factor in the range of 0.02 - 0.15 compared to older HTR fuel. Also in the development of fuel element graphite, a tendency towards lower diffusion coefficients for both nuclides can be derived. Special heating tests focussing on the fission gases and iodine release from the matrix contamination have been evaluated to derive corresponding effective diffusion data for iodine in fuel element graphite which are more realistic than the iodine transport data used so far. Finally, a prediction of krypton and cesium release from spherical fuel elements under heating conditions will be given for fuel elements which at present are irradiated in the FRJ2, Juelich, and which are intended to be heated at 1600/1800 deg. C in the KueFA furnace in near future. (author). 7 refs, 11 figs

  17. Evaluation of the release behavior of the dexamethasone embedded in polycarbonate polyurethane membranes: an in vitro study

    International Nuclear Information System (INIS)

    Kim, Dong Hyun; Kang, Sung Gwon; Lee, Chul Gab; Park, Sang Soo; Lee, Don Haeng; Lee, Gyu Baek; Song, Ho Young

    2003-01-01

    To evaluate the release behavior of dexamethasone embedded in a polycarbonate polyurethane membrane. Both water-soluble and water-insoluble dexamethasone were tested, and the release behavior of five water-insoluble dexamethasone films of different thickness (78 to 211 μm) was also evaluated. The amount of dexamethasone used was 10% of the total weight of the polyurethan film mass. Each film was placed in a centrifuge tube containing 25 ml of 0.1-M neutral phosphate buffer, and the tubes were placed in a shaking incubator to quantify the amount of drug released into the buffer, absorption spectroscopy (λ max=242 nm) was employed. In the test involving water-soluble dexamethasone, 60%, of the drug was released during the first two hours of the study. Films containing water-insoluble dexamethasone, on the other hand, released 40%, 60% and 75% of the dexamethasone in one, three and seven days, respectively. Both types of film maintained low-dose drug release for 28 days. When release behavior was compared between water-insoluble films of different thickness, thicker film showed less initial burst and more sustained release. Dexamethasone release behavior varies according to drug solubility and membrane thickness, and may thus be conrolled

  18. Dimorphic ejaculates and sperm release strategies associated with alternative mating behaviors in the squid.

    Science.gov (United States)

    Apostólico, Lígia H; Marian, José E A R

    2017-11-01

    Sperm competition is a powerful postcopulatory selective force influencing male adaptations associated with increasing fertilization success, and it is usually related to the evolution of different strategies of ejaculate expenditure between individuals. Ejaculates may also be influenced by additional selective pressures associated with sperm competition, such as timing between insemination and fertilization, female reproductive tract morphology, and fertilization environment. Also, males that adopt alternative mating tactics may face distinct sperm competition pressures, which may lead to the evolution of intraspecific diversity in ejaculates. In loliginid squids, males with alternative reproductive tactics (sneakers and consorts) differ not only in mating behavior, but also transfer spermatophores into two distinct sites within the female. Here, we compared structure and functioning of spermatophores between sneakers and consorts in the squid Doryteuthis plei applying microscopy techniques and in vitro experiments. Sneakers and consorts exhibit differences in spermatophore structure that lead to distinct spermatophoric reactions and spermatangium morphologies. Moreover, in sneakers, sperm release lasts longer and their sperm show an aggregative behavior not detected in consorts. Slow sperm release may be a strategy to guarantee longer sperm provision, given the wide interval between sneaker mating and egg release. For consorts, in turn, intense and quick sperm discharge may be advantageous, as timing between mating and egg-laying is relatively short. Within the complex squid mating system, factors such as (i) different fertilization sites and (ii) interval between mating and egg release may also influence sperm competition, and ultimately shape the evolution of divergent ejaculates between dimorphic males. © 2017 Wiley Periodicals, Inc.

  19. Associations among Life Events, Empathic Concern, and Adolescents' Prosocial and Aggressive Behaviors Toward Specific Targets.

    Science.gov (United States)

    Davis, Alexandra N; Luce, Haley; Davalos, Natasha

    2018-05-25

    The goal of the present study was to examine the links between life events and adolescents' social behaviors (prosocial and aggressive behaviors) toward specific targets and to examine how empathic concern may play a role in these associations. The study examined two hypotheses: both the mediating role of empathic concern and the moderating role of empathic concern. The sample included 311 high school students from the Midwest (M age = 16.10 years; age range = 14-19 years; 58.7% girls; 82.7% White, 13.6% Latino). The results demonstrated support for the moderation model as well as complex links between life events and prosocial and aggressive behaviors toward specific targets. The discussion focuses on the role of empathic concern in understanding how life events are ultimately associated with adolescents' social development.

  20. Surfacing behavior and gas release of the physostome sprat (Sprattus sprattus) in ice-free and ice-covered waters

    KAUST Repository

    Solberg, Ingrid; Kaartvedt, Stein

    2013-01-01

    Upward-facing echosounders that provided continuous, long-term measurements were applied to address the surfacing behavior and gas release of the physostome sprat (Sprattus sprattus) throughout an entire winter in a 150-m-deep Norwegian fjord

  1. Behavior coordination of mobile robotics using supervisory control of fuzzy discrete event systems.

    Science.gov (United States)

    Jayasiri, Awantha; Mann, George K I; Gosine, Raymond G

    2011-10-01

    In order to incorporate the uncertainty and impreciseness present in real-world event-driven asynchronous systems, fuzzy discrete event systems (DESs) (FDESs) have been proposed as an extension to crisp DESs. In this paper, first, we propose an extension to the supervisory control theory of FDES by redefining fuzzy controllable and uncontrollable events. The proposed supervisor is capable of enabling feasible uncontrollable and controllable events with different possibilities. Then, the extended supervisory control framework of FDES is employed to model and control several navigational tasks of a mobile robot using the behavior-based approach. The robot has limited sensory capabilities, and the navigations have been performed in several unmodeled environments. The reactive and deliberative behaviors of the mobile robotic system are weighted through fuzzy uncontrollable and controllable events, respectively. By employing the proposed supervisory controller, a command-fusion-type behavior coordination is achieved. The observability of fuzzy events is incorporated to represent the sensory imprecision. As a systematic analysis of the system, a fuzzy-state-based controllability measure is introduced. The approach is implemented in both simulation and real time. A performance evaluation is performed to quantitatively estimate the validity of the proposed approach over its counterparts.

  2. Anisotropic kinetic energy release and gyroscopic behavior of CO2 super rotors from an optical centrifuge

    Science.gov (United States)

    Murray, Matthew J.; Ogden, Hannah M.; Mullin, Amy S.

    2017-10-01

    An optical centrifuge is used to generate an ensemble of CO2 super rotors with oriented angular momentum. The collision dynamics and energy transfer behavior of the super rotor molecules are investigated using high-resolution transient IR absorption spectroscopy. New multipass IR detection provides improved sensitivity to perform polarization-dependent transient studies for rotational states with 76 ≤ J ≤ 100. Polarization-dependent measurements show that the collision-induced kinetic energy release is spatially anisotropic and results from both near-resonant energy transfer between super rotor molecules and non-resonant energy transfer between super rotors and thermal molecules. J-dependent studies show that the extent and duration of the orientational anisotropy increase with rotational angular momentum. The super rotors exhibit behavior akin to molecular gyroscopes, wherein molecules with larger amounts of angular momentum are less likely to change their angular momentum orientation through collisions.

  3. Reduced fatalism and increased prevention behavior after two high-profile lung cancer events.

    Science.gov (United States)

    Portnoy, David B; Leach, Corinne R; Kaufman, Annette R; Moser, Richard P; Alfano, Catherine M

    2014-01-01

    The positive impact of media coverage of high-profile cancer events on cancer prevention behaviors is well-established. However, less work has focused on potential adverse psychological reactions to such events, such as fatalism. Conducting 3 studies, the authors explored how the lung cancer death of Peter Jennings and diagnosis of Dana Reeve in 2005 related to fatalism. Analysis of a national media sample in Study 1 found that media coverage of these events often focused on reiterating the typical profile of those diagnosed with lung cancer; 38% of the media mentioned at least 1 known risk factor for lung cancer, most often smoking. Data from a nationally representative survey in Study 2 found that respondents reported lower lung cancer fatalism, after, compared with before, the events (OR = 0.16, 95% CI [0.03, 0.93]). A sustained increase in call volume to the national tobacco Quitline after these events was found in Study 3. These results suggest that there is a temporal association between high-profile cancer events, the subsequent media coverage, psychological outcomes, and cancer prevention behaviors. These results suggest that high-profile cancer events could be leveraged as an opportunity for large-scale public heath communication campaigns through the dissemination of cancer prevention messages and services.

  4. Abnormal occipital event-related potentials in Parkinson's disease with concomitant REM sleep behavior disorder.

    Science.gov (United States)

    Gaudreault, Pierre-Olivier; Gagnon, Jean-François; Montplaisir, Jacques; Vendette, Mélanie; Postuma, Ronald B; Gagnon, Katia; Gosselin, Nadia

    2013-02-01

    Rapid eye movement sleep behavior disorder is found in 33-46% of patients with Parkinson's disease and was shown to be associated with cognitive deficits. Our goal was to improve our understanding of the role of this sleep disorder in cerebral dysfunction occurring in Parkinson's disease using a visual cognitive task and event-related potentials. Sixteen patients with Parkinson's disease and rapid eye movement sleep behavior disorder, 15 patients with Parkinson's disease without rapid eye movement sleep behavior disorder and 16 healthy control subjects were included. The amplitude and latency of event-related potentials were compared between groups. No group differences were found for reaction times or accuracy. A Group effect was found for P2 wave amplitude; patients with rapid eye movement sleep behavior disorder had increased P2 in comparison with the control group (p disorder were associated with abnormal visual P2 component of event-related potentials. Although patients with Parkinson's disease alone were not significantly different from patients with combined Parkinson's disease and rapid eye movement sleep behavior disorder, their P2 amplitudes were not sufficiently abnormal to differ from that of control subjects. This study confirms that rapid eye movement sleep behavior disorder accentuates cerebral dysfunctions in Parkinson's disease. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. Effect of corticotropin-releasing factor receptor antagonist on psychologically suppressed masculine sexual behavior in rats.

    Science.gov (United States)

    Miwa, Yoshiji; Nagase, Keiko; Oyama, Nobuyuki; Akino, Hironobu; Yokoyama, Osamu

    2011-03-01

    Corticotropin-releasing factor (CRF) coordinates various responses of the body to stress, and CRF receptors are important targets of treatment for stress-related disorders. To investigate the effect of a nonselective CRF receptor antagonist, astressin, on suppression of masculine sexual behavior by psychological stress in rats. First, we investigated the influence of psychological stress, induced 2 hours per day for three consecutive days, on sexual behavior. Then, rats were divided into 4 groups: a control group, an astressin administration group (A), a psychological stress loading group (PS), and a psychological stress loading and astressin administration group (PS + A). The rats were exposed to sham or psychological stress for three consecutive days. After the last stress loading, the rats were injected with vehicle or astressin, and their sexual behavior was observed. We also measured serum levels of adrenocorticotropic hormone (ACTH). The effects of astressin on sexual behavior and serum levels of ACTH in rats affected by psychological stress were determined. Sexual behavior was reduced after psychological stress loading. The PS rats had significantly longer mount, intromission, and ejaculation latencies and lower ejaculation frequency than did the control, A, and PS + A rats. The intromission latency and ejaculation frequency in the PS + A rats did not achieve the level observed in the controls. There was no significant difference in these parameters between the control and A rats. Serum ACTH levels were significantly lower in PS + A rats than in PS rats. Psychologically suppressed masculine sexual behavior could be partially recovered with astressin administration in rats. These data provide a rationale for the further study of CRF receptor antagonists as novel agents for treating psychological sexual disorders. © 2010 International Society for Sexual Medicine.

  6. The Interactive Effects of Stressful Family Life Events and Cortisol Reactivity on Adolescent Externalizing and Internalizing Behaviors

    Science.gov (United States)

    Steeger, Christine M.; Cook, Emily C.; Connell, Christian M.

    2016-01-01

    This study investigated the associations between stressful family life events and adolescent externalizing and internalizing behaviors, and the interactive effects of family life events and cortisol reactivity on problem behaviors. In a sample of 100 mothers and their adolescents (M age = 15.09; SD age = 0.98; 68% girls), adolescent cortisol reactivity was measured in response to a mother-adolescent conflict interaction task designed to elicit a stress response. Mothers reported on measures of family life events and adolescent problem behaviors. Results indicated that a heightened adolescent cortisol response moderated the relations between stressful family life events and both externalizing and internalizing behaviors. Results support context-dependent theoretical models, suggesting that for adolescents with higher cortisol reactivity (compared to those with lower cortisol reactivity), higher levels of stressful family life events were associated with greater problem behaviors, whereas lower levels of stressful family life events were related to fewer problem behaviors. PMID:26961703

  7. An Observational Analysis of Coaching Behaviors for Career Development Event Teams: A Mixed Methods Study

    Science.gov (United States)

    Ball, Anna L.; Bowling, Amanda M.; Sharpless, Justin D.

    2016-01-01

    School Based Agricultural Education (SBAE) teachers can use coaching behaviors, along with their agricultural content knowledge to help their Career Development Event (CDE) teams succeed. This mixed methods, collective case study observed three SBAE teachers preparing multiple CDEs throughout the CDE season. The teachers observed had a previous…

  8. Process variant comparison: using event logs to detect differences in behavior and business rules

    NARCIS (Netherlands)

    Bolt, A.; de Leoni, M.; van der Aalst, W.M.P.

    2018-01-01

    This paper addresses the problem of comparing different variants of the same process. We aim to detect relevant differences between processes based on what was recorded in event logs. We use transition systems to model behavior and to highlight differences. Transition systems are annotated with

  9. Tritium recapture behavior at a nuclear power reactor due to airborne releases.

    Science.gov (United States)

    Harris, Jason T; Miller, David W; Foster, Doug W

    2008-08-01

    This paper describes the initiatives taken by Cook Nuclear Plant to study the on-site behavior of recaptured tritium released in its airborne effluents. Recapture is the process where a released radioactive effluent, in this case tritium, is brought back on-site through some mechanism. Precipitation, shifts in wind direction, or anthropogenic structures that restrict or alter effluent movement can all lead to recapture. The investigation was started after tritium was detected in the north storm drain outfall. Recent inadvertent tritium releases by several other nuclear power plants, many of which entered the groundwater, have led to increased surveillance and scrutiny by regulatory authorities and the general public. To determine the source of tritium in the outfall, an on-site surface water, well water, rainwater and air-conditioning condensate monitoring program was begun. Washout coefficients were also determined to compare with results reported by other nuclear power plants. Program monitoring revealed detectable tritium concentrations in several precipitation sample locations downwind of the two monitored containment building release vents. Tritium was found in higher concentrations in air-conditioning condensate, with a mean value of 528 Bq L(-1) (14,300 pCi L(-1)). The condensate, and to a lesser extent rainwater, were contributing to the tritium found in the north storm drain outfall. Maximum concentration values for each sample type were used to estimate the most conservative dose. A maximum dose of 1.1 x 10(-10) mSv (1.1 x 10(-8) mrem) total body was calculated to determine the health impact of the tritium detected.

  10. Demographic Predictors of Event-Level Associations between Alcohol Consumption and Sexual Behavior.

    Science.gov (United States)

    Wells, Brooke E; Rendina, H Jonathon; Kelly, Brian C; Golub, Sarit A; Parsons, Jeffrey T

    2016-02-01

    Alcohol consumption is associated with sexual behavior and outcomes, though research indicates a variety of moderating factors, including demographic characteristics. To better target interventions aimed at alcohol-related sexual risk behavior, our analyses simultaneously examine demographic predictors of both day- and event-level associations between alcohol consumption and sexual behavior in a sample of young adults (N = 301) who are sexually active and consume alcohol. Young adults (aged 18-29) recruited using time-space sampling and incentivized snowball sampling completed a survey and a timeline follow-back calendar reporting alcohol consumption and sexual behavior in the past 30 days. On a given day, a greater number of drinks consumed was associated with higher likelihood of sex occurring, particularly for women and single participants. During a given sexual event, number of drinks consumed was not associated with condom use, nor did any demographic predictors predict that association. Findings highlight associations between alcohol and sexual behavior, though not between alcohol and sexual risk behavior, highlighting the need for additional research exploring the complex role of alcohol in sexual risk behavior and the need to develop prevention efforts to minimize the role of alcohol in the initiation of sexual encounters.

  11. Fission Product Release Behavior of Individual Coated Fuel Particles for High-Temperature Gas-Cooled Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Minato, Kazuo [Japan Atomic Energy Research Institute (Japan); Sawa, Kazuhiro [Japan Atomic Energy Research Institute (Japan); Koya, Toshio [Japan Atomic Energy Research Institute (Japan); Tomita, Takeshi [Japan Atomic Energy Research Institute (Japan); Ishikawa, Akiyoshi [Japan Atomic Energy Research Institute (Japan); Baldwin, Charles A; Gabbard, William Alexander [Oak Ridge National Laboratory (United States); Malone, Charlie M [Oak Ridge National Laboratory (United States)

    2000-07-15

    Postirradiation heating tests of TRISO-coated UO{sub 2} particles at 1700 and 1800degC were performed to understand fission product release behavior at accident temperatures. The inventory measurements of the individual particles were carried out before and after the heating tests with gamma-ray spectrometry to study the behavior of the individual particles. The time-dependent release behavior of {sup 85}Kr, {sup 110m}Ag, {sup 134}Cs, {sup 137}Cs, and {sup 154}Eu were obtained with on-line measurements of fission gas release and intermittent measurements of metallic fission product release during the heating tests. The inventory measurements of the individual particles revealed that fission product release behavior of the individual particles was not uniform, and large particle-to-particle variations in the release behavior of {sup 110m}Ag, {sup 134}Cs, {sup 137}Cs, and {sup 154}Eu were found. X-ray microradiography and ceramography showed that the variations could not be explained by only the presence or absence of cracks in the SiC coating layer. The SiC degradation may have been related to the variations.

  12. Fission Product Release Behavior of Individual Coated Fuel Particles for High-Temperature Gas-Cooled Reactors

    International Nuclear Information System (INIS)

    Minato, Kazuo; Sawa, Kazuhiro; Koya, Toshio; Tomita, Takeshi; Ishikawa, Akiyoshi; Baldwin, Charles A.; Gabbard, William Alexander; Malone, Charlie M.

    2000-01-01

    Postirradiation heating tests of TRISO-coated UO 2 particles at 1700 and 1800degC were performed to understand fission product release behavior at accident temperatures. The inventory measurements of the individual particles were carried out before and after the heating tests with gamma-ray spectrometry to study the behavior of the individual particles. The time-dependent release behavior of 85 Kr, 110m Ag, 134 Cs, 137 Cs, and 154 Eu were obtained with on-line measurements of fission gas release and intermittent measurements of metallic fission product release during the heating tests. The inventory measurements of the individual particles revealed that fission product release behavior of the individual particles was not uniform, and large particle-to-particle variations in the release behavior of 110m Ag, 134 Cs, 137 Cs, and 154 Eu were found. X-ray microradiography and ceramography showed that the variations could not be explained by only the presence or absence of cracks in the SiC coating layer. The SiC degradation may have been related to the variations

  13. When an event sparks behavior change: an introduction to the sentinel event method of dynamic model building and its application to emergency medicine.

    Science.gov (United States)

    Boudreaux, Edwin D; Bock, Beth; O'Hea, Erin

    2012-03-01

    Experiencing a negative consequence related to one's health behavior, like a medical problem leading to an emergency department (ED) visit, can promote behavior change, giving rise to the popular concept of the "teachable moment." However, the mechanisms of action underlying this process of change have received scant attention. In particular, most existing health behavior theories are limited in explaining why such events can inspire short-term change in some and long-term change in others. Expanding on recommendations published in the 2009 Academic Emergency Medicine consensus conference on public health in emergency medicine (EM), we propose a new method for developing conceptual models that explain how negative events, like medical emergencies, influence behavior change, called the Sentinel Event Method. The method itself is atheoretical; instead, it defines steps to guide investigations that seek to relate specific consequences or events to specific health behaviors. This method can be used to adapt existing health behavior theories to study the event-behavior change relationship or to guide formulation of completely new conceptual models. This paper presents the tenets underlying the Sentinel Event Method, describes the steps comprising the process, and illustrates its application to EM through an example of a cardiac-related ED visit and tobacco use. © 2012 by the Society for Academic Emergency Medicine.

  14. Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice

    Science.gov (United States)

    Zhang, Rong; Asai, Masato; Mahoney, Carrie E; Joachim, Maria; Shen, Yuan; Gunner, Georgia; Majzoub, Joseph A

    2016-01-01

    A long-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates neuroendocrine functions such as adrenal glucocorticoid release, while extra-hypothalamic CRH plays a key role in stressor-triggered behaviors. Here we report that hypothalamus-specific Crh knockout mice (Sim1CrhKO mice, created by crossing Crhflox with Sim1Cre mice) have absent Crh mRNA and peptide mainly in the paraventricular nucleus of the hypothalamus (PVH) but preserved Crh expression in other brain regions including amygdala and cerebral cortex. As expected, Sim1CrhKO mice exhibit adrenal atrophy as well as decreased basal, diurnal and stressor-stimulated plasma corticosterone secretion and basal plasma ACTH, but surprisingly, have a profound anxiolytic phenotype when evaluated using multiple stressors including open field, elevated plus maze, holeboard, light-dark box, and novel object recognition task. Restoring plasma corticosterone did not reverse the anxiolytic phenotype of Sim1CrhKO mice. Crh-Cre driver mice revealed that PVHCrh fibers project abundantly to cingulate cortex and the nucleus accumbens shell, and moderately to medial amygdala, locus coeruleus, and solitary tract, consistent with the existence of PVHCrh-dependent behavioral pathways. Although previous, nonselective attenuation of CRH production or action, genetically in mice and pharmacologically in humans, respectively, has not produced the anticipated anxiolytic effects, our data show that targeted interference specifically with hypothalamic Crh expression results in anxiolysis. Our data identify neurons that express both Sim1 and Crh as a cellular entry point into the study of CRH-mediated, anxiety-like behaviors and their therapeutic attenuation. PMID:27595593

  15. Unsafe and violent behavior in commercials aired during televised major sporting events.

    Science.gov (United States)

    Tamburro, Robert F; Gordon, Patricia L; D'Apolito, James P; Howard, Scott C

    2004-12-01

    Injuries are the leading cause of death in children, and media exposure seems to increase children's risk-taking behavior. Televised sports are commonly viewed by children. The objective of this study was to determine the proportion of commercials that depict violence or other unsafe behavior during major televised sporting events that are aired before 9:00 pm. We obtained a list of the 50 sports programs that were most highly rated by Nielsen Media Research and that were televised between September 1, 2001, and September 1, 2002. These 50 programs included Winter Olympics events (n = 15), National Football League (NFL) regular season games (n = 14), NFL playoff games (n = 10), Major League Baseball World Series and playoff games (n = 7), the NFL Super Bowl (n = 1), the National Basketball Association Western Conference Final Game (n = 1), the College Football Rose Bowl (n = 1), and the National Collegiate Athletic Association Basketball Championship game (n = 1). Two other events were reviewed as well: the final round of the Masters Golf Championship, because it was the only sporting event rated in the top 50 of the previous year that was not represented by a similar sporting event in the study year, and the Daytona 500 National Association for Stock Car Auto Racing race, because it was the only event rated among the top 75 of the study year that was not represented by a similar event (ie, there were no other golfing or auto racing events reviewed). These events were included because different sporting events may attract different viewers and different advertisements; thus, their inclusion provides a more comprehensive evaluation of the topic. For sporting events with >3 programs in the top 50 (NFL regular season games, NFL playoff games, Winter Olympic events, and Major League Baseball World Series), representative samples of events were assessed. Surrogate events were analyzed for programs that were aired after 9:00 PM (Eastern Time) to control for the reduced

  16. Events

    Directory of Open Access Journals (Sweden)

    Igor V. Karyakin

    2016-02-01

    Full Text Available The 9th ARRCN Symposium 2015 was held during 21st–25th October 2015 at the Novotel Hotel, Chumphon, Thailand, one of the most favored travel destinations in Asia. The 10th ARRCN Symposium 2017 will be held during October 2017 in the Davao, Philippines. International Symposium on the Montagu's Harrier (Circus pygargus «The Montagu's Harrier in Europe. Status. Threats. Protection», organized by the environmental organization «Landesbund für Vogelschutz in Bayern e.V.» (LBV was held on November 20-22, 2015 in Germany. The location of this event was the city of Wurzburg in Bavaria.

  17. Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation

    International Nuclear Information System (INIS)

    Tomic, S.Lj.; Micic, M.M.; Filipovic, J.M.; Suljovrujic, E.H.

    2007-01-01

    The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the swelling characteristics and the releasing behavior of hydrogels, and the effect of different drugs, theophylline (TPH) and fenethylline hydrochloride (FE), on the releasing behavior of P(HEMA/IA) matrix were investigated in vitro. The diffusion exponents for swelling and drug release indicate that the mechanisms of buffer uptake and drug release are governed by Fickian diffusion. The swelling kinetics and, therefore, the release rate depends on the matrix swelling degree. The drug release was faster for copolymeric hydrogels with a higher content of itaconic acid. Furthermore, the drug release for TPH as model drug was faster due to a smaller molecular size and a weaker interaction of the TPH molecules with(in) the P(HEMA/IA) copolymeric networks

  18. Regulation of feeding behavior and psychomotor activity by corticotropin-releasing hormone (CRH in fish

    Directory of Open Access Journals (Sweden)

    Kouhei eMatsuda

    2013-05-01

    Full Text Available Corticotropin-releasing hormone (CRH is a hypothalamic neuropeptide belonging to a family of neuropeptides that includes urocortins, urotensin I and sauvagine in vertebrates. CRH and urocortin act as anorexigenic factors for satiety regulation in fish. In a goldfish model, intracerebroventricular (ICV administration of CRH has been shown to affect not only food intake, but also locomotor and psychomotor activities. In particular, CRH elicits anxiety-like behavior as an anxiogenic neuropeptide in goldfish, as is the case in rodents. This paper reviews current knowledge of CRH and its related peptides derived from studies of teleost fish, as representative non-mammals, focusing particularly on the role of the CRH system, and examines its significance from a comparative viewpoint.

  19. The influence of spray-drying parameters on phase behavior, drug distribution, and in vitro release of injectable microspheres for sustained release.

    Science.gov (United States)

    Meeus, Joke; Lenaerts, Maité; Scurr, David J; Amssoms, Katie; Davies, Martyn C; Roberts, Clive J; Van Den Mooter, Guy

    2015-04-01

    For ternary solid dispersions, it is indispensable to characterize their structure, phase behavior, and the spatial distribution of the dispersed drug as this might influence the release profile and/or stability of these formulations. This study shows how formulation (feed concentration) and process (feed rate, inlet air temperature, and atomizing air pressure) parameters can influence the characteristics of ternary spray-dried solid dispersions. The microspheres considered here consist of a poly(lactic-co-glycolic acid) (PLGA) surface layer and an underlying polyvinylpyrrolidone (PVP) phase. A poorly soluble active pharmaceutical ingredient (API) was molecularly dispersed in this matrix. Differences were observed in component miscibility, phase heterogeneity, particle size, morphology, as well as API surface coverage for selected spray-drying parameters. Observed differences are likely because of changes in the droplet generation, evaporation, and thus particle formation processes. However, varying particle characteristics did not influence the drug release of the formulations studied, indicating the robustness of this approach to produce particles of consistent drug release characteristics. This is likely because of the fact that the release is dominated by diffusion from the PVP layer through pores in the PLGA surface layer and that observed differences in the latter have no influence on the release. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

  20. Tandem mass spectrometry of nitric oxide and hydrogen sulfide releasing aspirins: a hint into activity behavior.

    Science.gov (United States)

    Crestoni, Maria Elisa; Chiavarino, Barbara; Guglielmo, Stefano; Lilla, Valentina; Fornarini, Simonetta

    2013-01-01

    Aspirin (acetylsalicylic acid, ASA) is the most popular non-steroidal anti-inflammatory drug. However, due to its action on cyclooxygenase and its acid nature, aspirin is associated with adverse gastrointestinal effects. In an effort to minimize these side effects, NO-donor and H2S-donor ASA co-drugs have been designed and tested. Their mass spectrometric behavior is now analyzed and reported. Positive ions were obtained by electrospray ionization involving protonation or alkali metal attachment. Their dissociation processes have been studied by collision induced dissociation in a triple quadrupole instrument. High mass accuracy measurements have been recorded on a Fourier transform ion cyclotron resonance mass spectrometer. The protonated molecules dissociate by an exclusive or largely prevailing path leading to acetyloxy-substituted benzoyl cation, namely an ASA unit. The process is reminiscent of the enzymatic hydrolysis, releasing intact ASA to a large extent. Only at higher collision energy does the formal ketene loss disrupt the ASA moiety. The gas phase chemistry of protonated ASA-releasing drugs develops along elementary dissociation steps analogous to the reactive processes in complex biological environments. This notion may provide a tool for preliminary testing of new compounds.

  1. Tritium behavior on a cultivated plot in the 1994 chronic HT release experiment at Chalk River

    International Nuclear Information System (INIS)

    Noguchi, H.; Yokoyama, S.; Kinouchi, N.; Murata, M.; Amano, H.; Atarashi, M.; Ichimasa, Y.; Ichimasa, M.

    1995-01-01

    The behavior of HT and HTO in air and surface soil has been studied extensively in the chronic HT release experiment carried out at Chalk River during the summer of 1994. HTO concentrations in air moisture and soil water collected in a cultivated plot showed similar time-variations, increasing rapidly during the first and second days and becoming gradual after the first 3-4 days. The air HTO concentration decreased during and following rainfall but recovered within a day. The rainfall reduced the HTO concentrations in ridge soil water but little in furrows. Time histories of HTO concentrations in air moisture and soil water suggest that the system was near steady-state within a continuous HT release period of 12 days, in spite of the presence of rain during the period. The air HTO concentrations on clear days showed diurnal cycles that were higher during daytime than at night. The experimental field had a very complex soil regime with respect to HT deposits. The deposits to soil surface varied depending on soil conditions. 12 refs., 5 figs

  2. Impact of pore characteristics of silica materials on loading capacity and release behavior of ibuprofen

    Energy Technology Data Exchange (ETDEWEB)

    Numpilai, Thanapha [Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900 (Thailand); Muenmee, Suthaporn [Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900 (Thailand); Center for Advanced Studies in Nanotechnology and Its Applications in Chemical Food and Agricultural Industries, Kasetsart University, Bangkok 10900 (Thailand); Witoon, Thongthai, E-mail: fengttwi@ku.ac.th [Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900 (Thailand); Center for Advanced Studies in Nanotechnology and Its Applications in Chemical Food and Agricultural Industries, Kasetsart University, Bangkok 10900 (Thailand); NANOTEC-KU-Center of Excellence on Nanoscale Materials Design for Green Nanotechnology, Kasetsart University, Bangkok 10900 (Thailand)

    2016-02-01

    Impact of pore characteristics of porous silica supports on loading capacity and release behavior of ibuprofen was investigated. The porous silica materials and ibuprofen-loaded porous silica materials were thoroughly characterized by N{sub 2}-sorption, thermal gravimetric and derivative weight analyses (TG-DTW), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) to determine the physical properties of materials, amount of ibuprofen adsorbed and position of ibuprofen. The detailed characterization reveals that the ibuprofen molecules adsorbed inside the mesopores. Increasing the mesopore size from 5 nm to 10 nm increased the ibuprofen loading from 0.74 to 0.85 mmol/g, respectively. Incorporation of macropore into the structure of porous silica materials enhanced the ibuprofen loading capacity of 11.8–20.3%. The ibuprofen-loaded bimodal meso-macroporous silica materials exhibited the highest dissolution of 92 wt.% within an hour. The ibuprofen particles deposited on the external surface of the porous silica materials showed a lower dissolution rate than the ibuprofen adsorbed inside the mesopores due to the formation of ibuprofen crystalline. - Highlights: • Impacts of pore characteristics of supports on adsorption and release of ibuprofen • Increasing mesopore size increased the ibuprofen loading and dissolution rate. • Macropores reduced the diffusion pathway of ibuprofen and dissolution medium.

  3. Impact of pore characteristics of silica materials on loading capacity and release behavior of ibuprofen

    International Nuclear Information System (INIS)

    Numpilai, Thanapha; Muenmee, Suthaporn; Witoon, Thongthai

    2016-01-01

    Impact of pore characteristics of porous silica supports on loading capacity and release behavior of ibuprofen was investigated. The porous silica materials and ibuprofen-loaded porous silica materials were thoroughly characterized by N 2 -sorption, thermal gravimetric and derivative weight analyses (TG-DTW), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) to determine the physical properties of materials, amount of ibuprofen adsorbed and position of ibuprofen. The detailed characterization reveals that the ibuprofen molecules adsorbed inside the mesopores. Increasing the mesopore size from 5 nm to 10 nm increased the ibuprofen loading from 0.74 to 0.85 mmol/g, respectively. Incorporation of macropore into the structure of porous silica materials enhanced the ibuprofen loading capacity of 11.8–20.3%. The ibuprofen-loaded bimodal meso-macroporous silica materials exhibited the highest dissolution of 92 wt.% within an hour. The ibuprofen particles deposited on the external surface of the porous silica materials showed a lower dissolution rate than the ibuprofen adsorbed inside the mesopores due to the formation of ibuprofen crystalline. - Highlights: • Impacts of pore characteristics of supports on adsorption and release of ibuprofen • Increasing mesopore size increased the ibuprofen loading and dissolution rate. • Macropores reduced the diffusion pathway of ibuprofen and dissolution medium.

  4. Impact of post-event avoidance behavior on commercial facilities sector venues-literature review.

    Energy Technology Data Exchange (ETDEWEB)

    Samsa, M. E.; Baldwin, T. E.; Berry, M. S.; Guzowski, L. B.; Martinez-Moyano, I.; Nieves, A. L.; Ramarasad, A. (Decision and Information Sciences)

    2011-03-24

    The terrorist attacks of September 11, 2001 (9/11), focused a great deal of interest and concern on how individual and social perceptions of risk change behavior and subsequently affect commercial sector venues. Argonne conducted a review of the literature to identify studies that quantify the direct and indirect economic consequences of avoidance behaviors that result from terrorist attacks. Despite a growing amount of literature addressing terrorism impacts, relatively little is known about the causal relationships between risk perception, human avoidance behaviors, and the economic effects on commercial venues. Nevertheless, the technical and academic literature does provide some evidence, both directly and by inference, of the level and duration of post-event avoidance behaviors on commercial venues. Key findings are summarized in this Executive Summary. Also included as an appendix is a more detailed summary table of literature findings reproduced from the full report.

  5. Environmental behavior of the radionuclides released from the Fukushima Daiichi Nuclear Power Plant accident

    International Nuclear Information System (INIS)

    Yamazaki, Hideo

    2014-01-01

    The environmental behavior of radioactive nuclides released from the Fukushima Daiichi Nuclear Power Station (FDNPS) accident in eastern Japan was investigated. The radioactive pollution of environmental samples, including airborne dust, soil, sediment, fish, and other organisms was described. It was evaluated for environmental behavior and fate of the radioactive material from the spatial and temporal distribution of the radioactive nuclides. In Higashiosaka City about 600 km away from FDNPS, it begins to detect the radioactive nuclides in the airborne dust from 25th March 2011. Radioactive fission products 95 Zr- 95 Nb was detected on 18th April. The concentrations of 131 I, 134 Cs, and 137 Cs in the soil collected from Fukushima City were 126000, 14000, and 14200 Bq/kg on 19th March 2011 and 12800, 13200, and 13700 Bq/kg on 26th March 2011, respectively. The concentrations of 131 I, 134 Cs, and 137 Cs in the soil samples collected from March-June 2011 from study sites in metropolitan area and Kanto region ranged from nd to 91900, 59 to 16100, and 69 to 17600 Bq/kg, respectively. (Concentrations of 131 I were done decay correction to the value of 16th March) Radioactivities in fish samples collected from off FDNPS, Tokyo Bay, and Kejonuma Pond were measured. The radioactive contamination of forest ecosystem was also investigated. Two processes are involved in the radioactive contamination of the environment from the FDNPS accident. One is contamination by radioactive nuclides released from the hydrogen explosion. Leakage of contaminated cooling water to the ocean is in other important environmental pollution. We must continue carefully monitoring of radioactive nuclides in the environment. (author)

  6. The effects of extreme rainfall events on carbon release from Biological Soil Crusts covered soil in fixed sand dunes in the Tengger Desert, northern China

    Science.gov (United States)

    Zhao, Yang; Li, Xinrong; Pan, Yanxia; Hui, Rong

    2016-04-01

    How soil cover types and extreme rainfall event influence carbon (C) release in temperate desert ecosystems has largely been unexplored. We assessed the effects of extreme rainfall (quantity and intensity) events on the carbon release from soils covered by different types of biological soil crusts (BSCs) in fixed sand dunes in the Tengger Desert, Shapotou regionof northern China. We removed intact crusts down to 10 cm and measured them in PVC mesocosms. A Li-6400-09 Soil Chamber was used to measure the respiration rates of the BSCs immediately after the rainfall stopped, and continued until the respiration rates of the BSCs returned to the pre-rainfall basal rate. Our results showed that almost immediately after extreme rainfall events the respiration rates of algae crust and mixed crust were significantly inhibited, but moss crust was not significantly affected. The respiration rates of algae crust, mixed crust, and moss crust in extreme rainfall quantity and intensity events were, respectively, 0.12 and 0.41 μmolCO2/(m2•s), 0.10 and 0.45 μmolCO2/(m2•s), 0.83 and 1.69 μmolCO2/(m2•s). Our study indicated that moss crust in the advanced succession stage can well adapt to extreme rainfall events in the short term. Keywords: carbon release; extreme rainfall events; biological soil crust

  7. Some effects of gas adsorption on the high temperature volatile release behavior of a terrestrial basalt, tektite and lunar soil

    Science.gov (United States)

    Graham, D. G.; Muenow, D. W.; Gibson, E. K., Jr.

    1979-01-01

    Mass pyrograms obtained from high-temperature, mass psectrometric pyrolysis of a glassy theoleiitic submarine basalt and a tektite, ground in air to less than 64 microns, have shown N2 and SO release patterns very similar to those from the pyrolysis of mature lunar soil fines. The N2 and CO release behavior from the terrestrial samples reproduces the biomodal, high-temperature (approximately 700 and 1050 C) features from the lunar samples. Unground portions of the basalt and tektite show no release of N2 and CO during pyrolysis. Grinding also alters the release behavior and absolute amounts of H2O and CO2. It is suggested that adsorption of atmospheric gases in addition to solar wind implantation of ions may account for the wide range of values in previously reported concentrations of carbon and nitrogen from lunar fines.

  8. Modeling crowd behavior based on the discrete-event multiagent approach

    OpenAIRE

    Лановой, Алексей Феликсович; Лановой, Артем Алексеевич

    2014-01-01

    The crowd is a temporary, relatively unorganized group of people, who are in close physical contact with each other. Individual behavior of human outside the crowd is determined by many factors, associated with his intellectual activities, but inside the crowd the man loses his identity and begins to obey more simple laws of behavior.One of approaches to the construction of multi-level model of the crowd using discrete-event multiagent approach was described in the paper.Based on this analysi...

  9. On the intracellular release mechanism of hydrophobic cargo and its relation to the biodegradation behavior of mesoporous silica nanocarriers.

    Science.gov (United States)

    von Haartman, Eva; Lindberg, Desiré; Prabhakar, Neeraj; Rosenholm, Jessica M

    2016-12-01

    The intracellular release mechanism of hydrophobic molecules from surface-functionalized mesoporous silica nanoparticles was studied in relation to the biodegradation behavior of the nanocarrier, with the purpose of determining the dominant release mechanism for the studied drug delivery system. To be able to follow the real-time intracellular release, a hydrophobic fluorescent dye was used as model drug molecule. The in vitro release of the dye was investigated under varying conditions in terms of pH, polarity, protein and lipid content, presence of hydrophobic structures and ultimately, in live cancer cells. Results of investigating the drug delivery system show that the degradation and drug release mechanisms display a clear interdependency in simple aqueous solvents. In pure aqueous media, the cargo release was primarily dependent on the degradation of the nanocarrier, while in complex media, mimicking intracellular conditions, the physicochemical properties of the cargo molecule itself and its interaction with the carrier and/or surrounding media were found to be the main release-governing factors. Since the material degradation was retarded upon loading with hydrophobic guest molecules, the cargo could be efficiently delivered into live cancer cells and released intracellularly without pronounced premature release under extracellular conditions. From a rational design point of view, pinpointing the interdependency between these two processes can be of paramount importance considering future applications and fundamental understanding of the drug delivery system. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. The Slip Behavior and Source Parameters for Spontaneous Slip Events on Rough Faults Subjected to Slow Tectonic Loading

    Science.gov (United States)

    Tal, Yuval; Hager, Bradford H.

    2018-02-01

    We study the response to slow tectonic loading of rough faults governed by velocity weakening rate and state friction, using a 2-D plane strain model. Our numerical approach accounts for all stages in the seismic cycle, and in each simulation we model a sequence of two earthquakes or more. We focus on the global behavior of the faults and find that as the roughness amplitude, br, increases and the minimum wavelength of roughness decreases, there is a transition from seismic slip to aseismic slip, in which the load on the fault is released by more slip events but with lower slip rate, lower seismic moment per unit length, M0,1d, and lower average static stress drop on the fault, Δτt. Even larger decreases with roughness are observed when these source parameters are estimated only for the dynamic stage of the rupture. For br ≤ 0.002, the source parameters M0,1d and Δτt decrease mutually and the relationship between Δτt and the average fault strain is similar to that of a smooth fault. For faults with larger values of br that are completely ruptured during the slip events, the average fault strain generally decreases more rapidly with roughness than Δτt.

  11. Gambling Behavior and Problem Gambling Reflecting Social Transition and Traumatic Childhood Events Among Greenland Inuit

    DEFF Research Database (Denmark)

    Larsen, Christina Viskum Lytken; Curtis, Tine; Bjerregaard, Peter

    2013-01-01

    gambling behavior and problem gambling among Greenland Inuit in relation to the ongoing social transition and traumatic events during childhood. A large representative cross-sectional study was conducted among Greenland Inuit (n = 2,189). Data was collected among adults (18+) in 9 towns and 13 villages...... in Greenland from 2005 to 2010. Problem gambling, gambling behavior and traumatic childhood events were measured through a self-administered questionnaire. The lie/bet screen was used to identify past year and lifetime problem gambling. Social transition was measured as place of residence and a combination...... of residence, education and occupation. The lifetime prevalence of problem gambling was 16 % among men and 10 % among women (p ...

  12. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation.

    Science.gov (United States)

    Uvnäs-Moberg, Kerstin; Handlin, Linda; Petersson, Maria

    2014-01-01

    Oxytocin, a hypothalamic nonapeptide, is linked to increased levels of social interaction, well-being and anti-stress effects. The effects of oxytocin that is released by sensory stimulation during different kinds of interactive behaviors are often underestimated or even forgotten. In fact, many of the positive effects caused during interaction, such a wellbeing, stress reduction and even health promotion, are indeed linked to oxytocin released in response to activation of various types of sensory nerves. Oxytocin is released in response to activation of sensory nerves during labor, breastfeeding and sexual activity. In addition oxytocin is released in response to low intensity stimulation of the skin, e.g., in response to touch, stroking, warm temperature, etc. Consequently oxytocin is not only released during interaction between mothers and infants, but also during positive interaction between adults or between humans and animals. Finally oxytocin is also released in response to suckling and food intake. Oxytocin released in the brain in response to sensory stimulation as a consequence of these types of interactive behaviors, contributes to every day wellbeing and ability to handle stress. Food intake or sex may be used or even abused to achieve oxytocin-linked wellbeing and stress relief to compensate for lack of good relationships or when the levels of anxiety are high. The present review article will summarize the role played by oxytocin released by sensory (in particular somatosensory) stimulation, during various kinds of interactive behaviors. Also the fact that the anti-stress effects of oxytocin are particularly strong when oxytocin is released in response to "low intensity" stimulation of the skin will be highlighted.

  13. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

    Directory of Open Access Journals (Sweden)

    Kerstin eUvnäs-Moberg

    2015-01-01

    Full Text Available Oxytocin, a hypothalamic nonapeptide, is linked to increased levels of social interaction, well-being and anti-stress effects. The effects of oxytocin that is released by sensory stimulation during different kinds of interactive behaviors are often underestimated or even forgotten. In fact, many of the positive effects caused during interaction, such a wellbeing, stress reduction and even health promotion, are indeed linked to oxytocin released in response to activation of various types of sensory nerves. Oxytocin is released in response to activation of sensory nerves during labor, breastfeeding and sexual activity. In addition oxytocin is released in response to low intensity stimulation of the skin, e.g. in response to touch, stroking, warm temperature etc . Consequently oxytocin is not only released during interaction between mothers and infants, but also during positive interaction between adult or between humans and animals. Finally oxytocin is also released in response to suckling and food intake. Oxytocin released in the brain in response to sensory stimulation as a consequence of these types of interactive behaviors, contributes to every day wellbeing and ability to handle stress. Food intake or sex may be used or even abused to achieve oxytocin-linked wellbeing and stress relief to compensate for lack of good relationships or when the levels of anxiety are high. The present review article will summarize the role played by oxytocin released by sensory (in particular somatosensory stimulation, during various kinds of interactive behaviors. Also the fact that the anti-stress effects of oxytocin are particularly strong when oxytocin is released in response to low intensity stimulation of the skin will be highlighted.

  14. The Effect Of Sponsorship Event And Publicity On Consumer Buying Behavior At PT. Sinar Galesong Manado

    OpenAIRE

    Pandowo, Merinda; Dawali, Achmad Dimas

    2016-01-01

    Companies usually pay attention to promotion of its brand in order to attract consumers, promotion is one of tools that supports marketing part to introduce the products to customers. Various promotional techniques are used by the marketer to influence the consumer decision making. The objectives of the research are to analyze the impact of sponsorship, event, and publicity to consumer buying behavior, partially and simultaneously. The research is quantitative type of research where investiga...

  15. Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures.

    Science.gov (United States)

    Holmes, Avram J; Hollinshead, Marisa O; O'Keefe, Timothy M; Petrov, Victor I; Fariello, Gabriele R; Wald, Lawrence L; Fischl, Bruce; Rosen, Bruce R; Mair, Ross W; Roffman, Joshua L; Smoller, Jordan W; Buckner, Randy L

    2015-01-01

    The goal of the Brain Genomics Superstruct Project (GSP) is to enable large-scale exploration of the links between brain function, behavior, and ultimately genetic variation. To provide the broader scientific community data to probe these associations, a repository of structural and functional magnetic resonance imaging (MRI) scans linked to genetic information was constructed from a sample of healthy individuals. The initial release, detailed in the present manuscript, encompasses quality screened cross-sectional data from 1,570 participants ages 18 to 35 years who were scanned with MRI and completed demographic and health questionnaires. Personality and cognitive measures were obtained on a subset of participants. Each dataset contains a T1-weighted structural MRI scan and either one (n=1,570) or two (n=1,139) resting state functional MRI scans. Test-retest reliability datasets are included from 69 participants scanned within six months of their initial visit. For the majority of participants self-report behavioral and cognitive measures are included (n=926 and n=892 respectively). Analyses of data quality, structure, function, personality, and cognition are presented to demonstrate the dataset's utility.

  16. Can sports events affect suicidal behavior? A review of the literature and implications for prevention.

    Science.gov (United States)

    Andriessen, Karl; Krysinska, Karolina

    2009-01-01

    Engagement in sports and physical activity, either actively as an athlete or in a passive way as a spectator, impacts interpersonal behavior and physical and mental health. The study reviews literature on the relationship between sports spectatorship and suicidal behavior to ascertain whether sports spectatorship has an impact on suicidal behavior, either increasing the risk or being a protective factor. The literature was searched via PubMed/MEDLINE and PsycINFO. Nine studies published between 1986 and 2006 were identified. The reviewed studies focused on the impact of sports events on the societal level, and analyzed data regarding national or local suicide rates. Their results indicate that sports events can have an impact on suicide mortality and morbidity, but this relationship seems to be mediated by age, gender, marital status, and alcohol consumption, as well as the process and outcome of the game (e.g., victory vs. defeat of the favored team). There is some evidence that sports events can reduce the rates of suicide on the societal level; however, there is a lack of studies exploring how sports spectatorship might influence levels of suicide risk in individuals and how mediating variables might operate on the individual level.

  17. Nurses’ Intention and Behavior in Reporting Adverse Event: Application of Theory of Planned Behavior

    Directory of Open Access Journals (Sweden)

    Ni Putu Ekayani

    2017-02-01

    Data menunjukkan bahwa secara global jumlah pelaporan insiden keselamatan pasien masih rendah, begitu juga di Rumah Sakit Baptis Batu, Jawa Timur. Penelitian ini bertujuan untuk mengetahui pengaruh antara sikap, norma subjektif, dan perceived behavioral control (PBC terhadap niat dan untuk menentukan hubungan antara PBC dan niat terhadap perilaku perawat dalam melaporkan kejadian tidak diharapkan (KTD. Penelitian ini menggunakan pendekatan potong lintang dan dilakukan di Rumah Sakit Baptis Batu pada tanggal 16-31 Maret 2016. Pengambilan data dilakukan dengan menggunakan kuesioner yang dibagikan kepada 82 (dari 85 perawat yang bekerja di Rumah Sakit Baptis Batu. Data dianalisis menggunakan regresi linier berganda dan korelasi Spearman. Hasil penelitian menunjukkan bahwa sikap (B = 0.496; nilai p = 0.000 dan PBC (B = 0.766; nilai p = 0.037 secara signifikan memengaruhi niat untuk melaporkan KTD, sedangkan norma subjektif (B= -0.087; nilai p = 0.540 tidak berpengaruh terhadap niat melaporkan KTD. Tidak terdapat hubungan antara PBC (r = 0.037; nilai p = 0.739 dan niat (r = 0.031; nilai p = 0.783 terhadap perilaku melaporkan KTD. Temuan ini menunjukkan bahwa niat perawat dalam melaporkan KTD dipengaruhi oleh sikap dan PBC, bukan norma subjektif. Sebaliknya, niat dan PBC tidak berhubungan dengan perilaku melaporkan KTD.

  18. The Impact of Cognitive Behavioral Therapy on Post Event Processing Among Those with Social Anxiety Disorder

    Science.gov (United States)

    Price, Matthew; Anderson, Page L.

    2011-01-01

    Individuals with social anxiety are prone to engage in post event processing (PEP), a post mortem review of a social interaction that focuses on negative elements. The extent that PEP is impacted by cognitive behavioral therapy (CBT) and the relation between PEP and change during treatment has yet to be evaluated in a controlled study. The current study used multilevel modeling to determine if PEP decreased as a result of treatment and if PEP limits treatment response for two types of cognitive behavioral treatments, a group-based cognitive behavioral intervention and individually based virtual reality exposure. These hypotheses were evaluated using 91 participants diagnosed with social anxiety disorder. The findings suggested that PEP decreased as a result of treatment, and that social anxiety symptoms for individuals reporting greater levels of PEP improved at a slower rate than those with lower levels of PEP. Further research is needed to understand why PEP attenuates response to treatment. PMID:21159328

  19. Dopamine Release and Uptake Impairments and Behavioral Alterations Observed in Mice that Model Fragile X Mental Retardation Syndrome.

    Science.gov (United States)

    Fulks, Jenny L; O'Bryhim, Bliss E; Wenzel, Sara K; Fowler, Stephen C; Vorontsova, Elena; Pinkston, Jonathan W; Ortiz, Andrea N; Johnson, Michael A

    2010-10-20

    In this study we evaluated the relationship between amphetamine-induced behavioral alterations and dopamine release and uptake characteristics in Fmr1 knockout (Fmr1 KO) mice, which model fragile X syndrome. The behavioral analyses, obtained at millisecond temporal resolution and 2 mm spatial resolution using a force-plate actometer, revealed that Fmr1 KO mice express a lower degree of focused stereotypy compared to wild type (WT) control mice after injection with 10 mg/kg (ip) amphetamine. To identify potentially related neurochemical mechanisms underlying this phenomenon, we measured electrically-evoked dopamine release and uptake using fast-scan cyclic voltammetry at carbon-fiber microelectrodes in striatal brain slices. At 10 weeks of age, dopamine release per pulse, which is dopamine release corrected for differences in uptake, was unchanged. However, at 15 (the age of behavioral testing) and 20 weeks of age, dopamine per pulse and the maximum rate of dopamine uptake was diminished in Fmr1 KO mice compared to WT mice. Dopamine uptake measurements, obtained at different amphetamine concentrations, indicated that dopamine transporters in both genotypes have equal affinities for amphetamine. Moreover, dopamine release measurements from slices treated with quinpirole, a D2-family receptor agonist, rule out enhanced D2 autoreceptor sensitivity as a mechanism of release inhibition. However, dopamine release, uncorrected for uptake and normalized against the corresponding pre-drug release peaks, increased in Fmr1 KO mice, but not in WT mice. Collectively, these data are consistent with a scenario in which a decrease in extracellular dopamine levels in the striatum result in diminished expression of focused stereotypy in Fmr1 KO mice.

  20. [Study on the correlation between adolescents' emotional and behavioral problems and life events].

    Science.gov (United States)

    Huang, Xue-zhu; Guo, Lan-ting; Tang, Guang-zheng

    2006-03-01

    To study the life events which are correlated with adolescent's emotion and behavior problems, and to provide evidence for clinicians and school staff to develop intervention for those problems. Youth's Self Report (YSR) and Adolescent Self-Rating Life Events Check List (ASLEC) were used to assess adolescent's emotional and behavioral problems and life events by 'spot' study. The referred group consisted of 585 patients from 11 to 18 years old in a Mental Health Centre of West China Hospital of Sichuan University from July in 2002 to March in 2004. Level of IQ was above 5th grade of primary school among the study subjects who were willing to fill in the YSR and ASLEC. The non-referred group was selected in a 1280 students cluster-sample from the schools of Chengdu city, whose sex, age and father's career were matched with the referred group. Variance inflation factor (VIF) was used to verify that there was no collinearity to each other in the 6 factors of ASLEC: interpersonal relationship, learning pressure, being punished, losing good adaptation and other. Linear stepwise regression was adopted. The YSR scores in referred group were higher than those in non-referred group, and the referred group had more emotional and behavioral problems than the non-referred one. Partial correlations ranged from 0.124 to 0.418 in referred group, and from 0.104 to 0.388 in non-referred group. Unsatisfied interpersonal relationship, heavy learning pressure, having been punished and poor adaptation were likely to increase the risk of youth's emotional and behavioral problems. More attention should be paid to help adolescents in the following areas: solving intrapersonal affairs, relieving pressure from learning, avoiding punishment, and improving ability to fit themselves to their surroundings.

  1. A Proposed Mechanism for Development of CTE Following Concussive Events: Head Impact, Water Hammer Injury, Neurofilament Release, and Autoimmune Processes.

    Science.gov (United States)

    Kornguth, Steven; Rutledge, Neal; Perlaza, Gabe; Bray, James; Hardin, Allen

    2017-12-19

    During the past decade, there has been an increasing interest in early diagnosis and treatment of traumatic brain injuries (TBI) that lead to chronic traumatic encephalopathy (CTE). The subjects involved range from soldiers exposed to concussive injuries from improvised explosive devices (IEDs) to a significant number of athletes involved in repetitive high force impacts. Although the forces from IEDs are much greater by a magnitude than those from contact sports, the higher frequency associated with contact sports allows for more controlled assessment of the mechanism of action. In our study, we report findings in university-level women soccer athletes followed over a period of four and a half years from accession to graduation. Parameters investigated included T1-, T2-, and susceptibility-weighted magnetic resonance images (SWI), IMPACT (Immediate Post-Concussion Assessment and Cognitive Testing), and C3 Logix behavioral and physiological assessment measures. The MRI Studies show several significant findings: first, a marked increase in the width of sulci in the frontal to occipital cortices; second, an appearance of subtle hemorrhagic changes at the base of the sulci; third was a sustained reduction in total brain volume in several soccer players at a developmental time when brain growth is generally seen. Although all of the athletes successfully completed their college degree and none exhibited long term clinical deficits at the time of graduation, the changes documented by MRI represent a clue to the pathological mechanism following an injury paradigm. The authors propose that our findings and those of prior publications support a mechanism of injury in CTE caused by an autoimmune process associated with the release of neural proteins from nerve cells at the base of the sulcus from a water hammer injury effect. As evidence accumulates to support this hypothesis, there are pharmacological treatment strategies that may be able to mitigate the development of

  2. A Proposed Mechanism for Development of CTE Following Concussive Events: Head Impact, Water Hammer Injury, Neurofilament Release, and Autoimmune Processes

    Directory of Open Access Journals (Sweden)

    Steven Kornguth

    2017-12-01

    Full Text Available During the past decade, there has been an increasing interest in early diagnosis and treatment of traumatic brain injuries (TBI that lead to chronic traumatic encephalopathy (CTE. The subjects involved range from soldiers exposed to concussive injuries from improvised explosive devices (IEDs to a significant number of athletes involved in repetitive high force impacts. Although the forces from IEDs are much greater by a magnitude than those from contact sports, the higher frequency associated with contact sports allows for more controlled assessment of the mechanism of action. In our study, we report findings in university-level women soccer athletes followed over a period of four and a half years from accession to graduation. Parameters investigated included T1-, T2-, and susceptibility-weighted magnetic resonance images (SWI, IMPACT (Immediate Post-Concussion Assessment and Cognitive Testing, and C3 Logix behavioral and physiological assessment measures. The MRI Studies show several significant findings: first, a marked increase in the width of sulci in the frontal to occipital cortices; second, an appearance of subtle hemorrhagic changes at the base of the sulci; third was a sustained reduction in total brain volume in several soccer players at a developmental time when brain growth is generally seen. Although all of the athletes successfully completed their college degree and none exhibited long term clinical deficits at the time of graduation, the changes documented by MRI represent a clue to the pathological mechanism following an injury paradigm. The authors propose that our findings and those of prior publications support a mechanism of injury in CTE caused by an autoimmune process associated with the release of neural proteins from nerve cells at the base of the sulcus from a water hammer injury effect. As evidence accumulates to support this hypothesis, there are pharmacological treatment strategies that may be able to mitigate the

  3. Antibacterial Behavior of Additively Manufactured Porous Titanium with Nanotubular Surfaces Releasing Silver Ions.

    Science.gov (United States)

    Amin Yavari, S; Loozen, L; Paganelli, F L; Bakhshandeh, S; Lietaert, K; Groot, J A; Fluit, A C; Boel, C H E; Alblas, J; Vogely, H C; Weinans, H; Zadpoor, A A

    2016-07-13

    Additive manufacturing (3D printing) has enabled fabrication of geometrically complex and fully interconnected porous biomaterials with huge surface areas that could be used for biofunctionalization to achieve multifunctional biomaterials. Covering the huge surface area of such porous titanium with nanotubes has been already shown to result in improved bone regeneration performance and implant fixation. In this study, we loaded TiO2 nanotubes with silver antimicrobial agents to equip them with an additional biofunctionality, i.e., antimicrobial behavior. An optimized anodizing protocol was used to create nanotubes on the entire surface area of direct metal printed porous titanium scaffolds. The nanotubes were then loaded by soaking them in three different concentrations (i.e., 0.02, 0.1, and 0.5 M) of AgNO3 solution. The antimicrobial behavior and cell viability of the developed biomaterials were assessed. As far as the early time points (i.e., up to 1 day) are concerned, the biomaterials were found to be extremely effective in preventing biofilm formation and decreasing the number of planktonic bacteria particularly for the middle and high concentrations of silver ions. Interestingly, nanotubes not loaded with antimicrobial agents also showed significantly smaller numbers of adherent bacteria at day 1, which may be attributed to the bactericidal effect of high aspect ratio nanotopographies. The specimens with the highest concentrations of antimicrobial agents adversely affected cell viability at day 1, but this effect is expected to decrease or disappear in the following days as the rate of release of silver ions was observed to markedly decrease within the next few days. The antimicrobial effects of the biomaterials, particularly the ones with the middle and high concentrations of antimicrobial agents, continued until 2 weeks. The potency of the developed biomaterials in decreasing the number of planktonic bacteria and hindering the formation of biofilms make

  4. Application of isotope tracer technique on the study of the filling and release behavior of carbon nanotubes

    International Nuclear Information System (INIS)

    Wu Shengwei; Guo Jinxue; Li Yan; Li Yulan; Li Wenxin; Liu Shiyuan

    2004-01-01

    The behaviors of washing and release of 110 Ag m -AgNO 3 from carbon nanotubes (CNTs), following soak of opened CNTs in 110 Ag m -AgNO 3 solutions are investigated with the isotope tracer technique. The filled CNTs samples are characterized by HREM, SEM, XRD and EDS. The amount of filled materials is also estimated by the isotope tracer technique. It shows that there are silver materials filled in the CNTs and would not release from the cavities. The results indicate that radioactive tracer is an effective and powerful technique to be applied into study of filling and release behaviors of CNTs as well as estimating the amount of filled materials. (authors)

  5. Effects of Polymeric Additives on the Crystallization and Release Behavior of Amorphous Ibuprofen

    Directory of Open Access Journals (Sweden)

    Su Yang Lee

    2013-01-01

    Full Text Available Some polymeric additives were studied to understand their effects on the amorphous phase of ibuprofen (IBU, used as a poorly water soluble pharmaceutical model compound. The amorphous IBU in bulk, as well as in nanopores (diameter ~24 nm of anodic aluminum oxide, was examined with the addition of poly(acrylic acid, poly(N-vinyl pyrrolidone, or poly(4-vinylphenol. Results of bulk crystallization showed that they were effective in limiting the crystal growth, while the nucleation of the crystalline phase in contact with water was nearly instantaneous in all cases. Poly(N-vinyl pyrrolidone, the most effective additive, was in specific interaction with IBU, as revealed by IR spectroscopy. The addition of the polymers was combined with the nanoscopic confinement to further stabilize the amorphous phase. Still, the IBU with addition of polymeric additives showed sustained release behavior. The current study suggested that the inhibition of the crystal nucleation was probably the most important factor to stabilize the amorphous phase and fully harness its high solubility.

  6. Impact of pore characteristics of silica materials on loading capacity and release behavior of ibuprofen.

    Science.gov (United States)

    Numpilai, Thanapha; Muenmee, Suthaporn; Witoon, Thongthai

    2016-02-01

    Impact of pore characteristics of porous silica supports on loading capacity and release behavior of ibuprofen was investigated. The porous silica materials and ibuprofen-loaded porous silica materials were thoroughly characterized by N2-sorption, thermal gravimetric and derivative weight analyses (TG-DTW), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) to determine the physical properties of materials, amount of ibuprofen adsorbed and position of ibuprofen. The detailed characterization reveals that the ibuprofen molecules adsorbed inside the mesopores. Increasing the mesopore size from 5nm to 10nm increased the ibuprofen loading from 0.74 to 0.85mmol/g, respectively. Incorporation of macropore into the structure of porous silica materials enhanced the ibuprofen loading capacity of 11.8-20.3%. The ibuprofen-loaded bimodal meso-macroporous silica materials exhibited the highest dissolution of 92wt.% within an hour. The ibuprofen particles deposited on the external surface of the porous silica materials showed a lower dissolution rate than the ibuprofen adsorbed inside the mesopores due to the formation of ibuprofen crystalline. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Tuning the Hydrophilic/Hydrophobic Balance to Control the Structure of Chitosan Films and Their Protein Release Behavior.

    Science.gov (United States)

    Becerra, Jose; Sudre, Guillaume; Royaud, Isabelle; Montserret, Roland; Verrier, Bernard; Rochas, Cyrille; Delair, Thierry; David, Laurent

    2017-05-01

    The control over the crystallinity of chitosan and chitosan/ovalbumin films can be achieved via an appropriate balance of the hydrophilic/hydrophobic interactions during the film formation process, which then controls the release kinetics of ovalbumin. Chitosan films were prepared by solvent casting. The presence of the anhydrous allomorph can be viewed as a probe of the hydrophobic conditions at the neutralization step. The semicrystalline structure, the swelling behavior of the films, the protein/chitosan interactions, and the release behavior of the films were impacted by the DA and the film processing parameters. At low DAs, the chitosan films neutralized in the solid state corresponded to the most hydrophobic environment, inducing the crystallization of the anhydrous allomorph with and without protein. The most hydrophilic conditions, leading to the hydrated allomorph, corresponded to non-neutralized films for the highest DAs. For the non-neutralized chitosan acetate (amorphous) films, the swelling increased when the DA decreased, whereas for the neutralized chitosan films, the swelling decreased. The in vitro release of ovalbumin (model protein) from chitosan films was controlled by their swelling behavior. For fast swelling films (DA = 45%), a burst effect was observed. On the contrary, a lag time was evidenced for DA = 2.5% with a limited release of the protein. Furthermore, by blending chitosans (DA = 2.5% and 45%), the release behavior was improved by reducing the burst effect and the lag time. The secondary structure of ovalbumin was partially maintained in the solid state, and the ovalbumin was released under its native form.

  8. Fast reactor fuel pin behavior analyses in a LOF type transient event

    International Nuclear Information System (INIS)

    Mizuno, Tomoyasu; Koyama, Shin-ichi; Kaito, Takeji; Uwaba, Tomoyuki; Tanaka, Kenya

    2013-06-01

    In order to evaluate integrity limiting parameters of fuel pins during fast reactor core transient events, such as fuel center line temperature and cladding maximum temperature, fuel pin behavior calculations were made using the fast reactor fuel pin performance code CEDAR. The temperature histories of fuel pins during a loss of flow (LOF) type transient events was calculated based on Ross and Stoute type gap conductance model and constant gap conductance model, which is used in a core transient calculation code like HIPRAC. The calculated maximum temperatures of cladding and adjacent coolant channel were lower in the case with Ross and Stoute type model than in the case of constant gap conductance model due to the dynamic change of gap conductance of former case. It is indicated that core transient calculations with constant gap conductance give conservative cladding and coolant temperatures than that with Ross and Stoute type gap conductance model which is thought to be realistic. (author)

  9. Behavioral Event Management: una proposta di applicazione della prospettiva comportamentale alla progettazione e organizzazione di eventi culturali

    Directory of Open Access Journals (Sweden)

    Federico Brunetti

    2016-06-01

    In this paper we try to apply the main results of behavioral research to the specific field of event management. The objective of this work is therefore to identify what the behavioral approach can suggest to improve the effectiveness in the management of cultural events. The underlying methodological approach followed in this paper is deductive. Within this frame, the orientation is prescriptive and aims to identify patterns of behavior to be suggested to event organizers. Following this methodology, some behavioral insights have been identifi ed: peak-end rule; sequence in pain and pleasure; anticipation; build commitment through choice; rituals; experienced vs remembered happiness. The present work seems to be one of the fi rst applications of behavioral approach to cultural event management. The use of behavioral perspective forces us to think about an event from an attendee’s perspective in the sense that it takes into consideration his psychological dimension, the “experience” that the event is creating in his memory. Those engaged in the organization of events will certainly benefi t, thus, from useful knowledge to optimize the effects of their actions.

  10. CONSUMERS' INTENTION TO ATTEND SOCCER EVENTS: APPLICATION AND EXTENSION OF THE THEORY OF PLANNED BEHAVIOR.

    Science.gov (United States)

    Eddosary, Melfy; Ko, Yong Jae; Sagas, Michael; Kim, Hee Youn

    2015-08-01

    The purpose of this study was to identify important factors of consumers' intention to attend professional soccer events among Saudi Arabian soccer fans. To explore the decision-making process of this relatively understudied population, the theory of planned behavior was used as theoretical background. Particularly, this study measured the effect of attitude, subjective norm, perceived behavioral control (time and money), and game importance on intention to attend, and examined the moderating role of commitment. Structural equation modeling (SEM) using 231 Saudi university students (M = 21.9 yr., SD = 1.21) indicate that attitude and game importance were significantly related to attendance intention. The effect of subjective norms was significant only for the low commitment group and game importance was more important for the low than the high commitment group.

  11. Behavior of phytoplankton during the ENSO event in the Pacific Ocean off Colombia

    International Nuclear Information System (INIS)

    Rojas Higuera, Paula J; Ortiz, Javier R.

    2007-01-01

    An analysis of the Phytoplankton behavior in the Colombian Pacific basin and its relation with physical and chemical variables present during the 1996 - 2000 period, in order to establish different behaviors during the occurrence of Enos (El Nino y la Nina) and under normal conditions and to define biological indicators. Eight new species of diatoms were detected during the Nino phenomenon and 6 new one during the Nina phenomenon. These new species can be considered as biological indicators. Dinoflagellate are better indicators of the Enos events than the diatoms, as it is the case for Ceratium fusus var. seta, C. tripos var. tripos and C. furca var. furca, which are biological indicators of the Nino phenomenon. During the Nina phenomenon, nine new species of Dinoflagellate were reported and considered as biological indicator belonging to Amphidinium, Goniodoma, Gonyaulax, Lingulodinium, Peridinium, Phalacroma, Polikrikos and Protoperidinium.

  12. Surfacing behavior and gas release of the physostome sprat (Sprattus sprattus) in ice-free and ice-covered waters

    KAUST Repository

    Solberg, Ingrid

    2013-10-04

    Upward-facing echosounders that provided continuous, long-term measurements were applied to address the surfacing behavior and gas release of the physostome sprat (Sprattus sprattus) throughout an entire winter in a 150-m-deep Norwegian fjord. During ice-free conditions, the sprat surfaced and released gas bubbles at night with an estimated surfacing rate of 3.5 times per fish day-1. The vertical swimming speeds during surfacing were considerably higher (~10 times) than during diel vertical migrations, especially when returning from the surface, and particularly when the fjord was not ice covered. The sprat released gas a few hours after surfacing, suggesting that the sprat gulped atmospheric air during its excursions to the surface. While the surface activity increased after the fjord became ice covered, the records of gas release decreased sharply. The under-ice fish then displayed a behavior interpreted as "searching for the surface" by repeatedly ascending toward the ice, apparently with limited success of filling the swim bladder. This interpretation was supported by lower acoustic target strength in ice-covered waters. The frequent surfacing behavior demonstrated in this study indicates that gulping of atmospheric air is an important element in the life of sprat. While at least part of the population endured overwintering in the ice-covered habitat, ice covering may constrain those physostome fishes that lack a gas-generating gland in ways that remain to be established. 2013 The Author(s).

  13. Evaporation release behavior of volatile fission products from liquid sodium pool to the inert cover gas

    Energy Technology Data Exchange (ETDEWEB)

    Nakagiri, T; Miyahara, S [Oarai Engineering Center, Power Reactor and Nuclear Fuel Development Corp., Oaraimachi, Ibaraki (Japan)

    1996-12-01

    In fuel failure of sodium cooled fast breeder reactors, released volatile fission products (VFPs) such as iodine and cesium from the fuel will be dissolved into the liquid sodium coolant and transferred to the cover vaporization. In the cover gas system of the reactor, natural convection occurs due to temperature differences between the sodium pool and the gas phase. The release rates of VFPs together with sodium vaporization are considered to be controlled by the convection. In this study, three analytical models are developed and examined to calculate the transient release rates using the equilibrium partition coefficients of VFPs. The calculated release rates are compared with experimental results for sodium and sodium iodide. The release rate of sodium is closest to the calculation by the heterogeneous nucleation theory. The release rate of sodium iodide obtained from the experiment is between the release rates calculated by the model based on heat-and-mass transfer analogy and the Hill`s theory. From this study, it is confirmed that the realistic release rate of sodium is able to be calculated by the model based on the heterogeneous nucleation theory. The conservative release rate of sodium iodide is able to be calculated by the model based on the Hill`s theory using the equilibrium partition coefficient of sodium iodide. (author) 7 figs., 1 tab., 3 refs.

  14. IDENTIFICATION OF PHARMACEUTICAL EXCIPIENT BEHAVIOR OF CHICKPEA (CICER ARIETINUM) STARCH IN GLICLAZIDE IMMEDIATE RELEASE TABLETS.

    Science.gov (United States)

    Meka, Venkata Srikanth; Yee, Phung; Sheshala, Ravi

    2016-01-01

    In the past few years, there are number of researchers carrying out their research on the excipients derived from polysaccharides and some of these researches show that natural excipients are comparable and can serve as an alternative to the synthetic excipients. Hence, the objectives of this research are to characterize the naturally sourced chickpea starch powder and to study the pharmaceutical excipient behavior of chickpea starch in gliclazide immediate release (IR) tablets. In this research, the binding properties of chickpea starch were compared to that of povidone, whereas the disintegrant properties of chickpea starch were compared to those of crospovidone, croscarmellose sodium and sodium starch glycolate. Flow property of chickpea starch was assessed with the measurement of bulk density, tapped density, compressibility index and angle of repose. Calibration curve for gliclazide in phosphate buffer pH 7.4 was developed. Gliclazide IR tablets were then produced with direct compression method. Physicochemical characteristics of the tablets, including thickness, tablet weight uniformity, hardness, disintegration time and friability were evaluated. Then, in vitro dissolution studies were performed by following United States Pharmacopeia (USP) dissolution method. The dissolution results were analyzed and compared with t30, t50, dissolution efficiency (DE). Lastly, drug-excipient compatibility studies, including Fourier transform infrared (FTIR) spectroscopic analysis and differential scanning calorimetric (DSC) analysis were carried out. Fair flow property was observed in the chickpea starch powder. Furthermore, the tablets produced passed all the tests in physicochemical characteristics evaluation except hardness and disintegration test. Additionally, in vitro dissolution studies show that chickpea starch acted as a disintegrant instead of a binder in gliclazide IR tablets and its disintegrant properties were comparable to those of crospovidone, croscarmellose

  15. Enrichment behavior and transport mechanism of soil-bound PAHs during rainfall-runoff events

    International Nuclear Information System (INIS)

    Zheng Yi; Luo Xiaolin; Zhang Wei; Wu Bin; Han Feng; Lin Zhongrong; Wang Xuejun

    2012-01-01

    Polycyclic Aromatic Hydrocarbons (PAHs) transported by surface runoff result in nonpoint source pollution and jeopardize aquatic ecosystems. The transport mechanism of PAHs during rainfall-runoff events has been rarely studied regarding pervious areas. An experimental system was setup to simulate the runoff pollution process on PAHs-contaminated soil. The enrichment behavior of soil-bound PAHs was investigated. The results show that soil organic matters (SOM), rather than clay particles, seem to be the main carrier of PAHs. The enrichment is highly conditioned on runoff and erosion processes, and its magnitude varies among PAH compounds. It is not feasible to build a simple and universal relationship between enrichment ratio and sediment discharge following the traditional enrichment theory. To estimate the flux of PAHs from pervious areas, soil erosion process has to be clearly understood, and both organic carbon content and composition of SOM should be factored into the calculation. - Highlights: ► Significant enrichment of particle-bound PAHs during rainfall-runoff events. ► Organic matters as the direct carrier of PAHs in runoff from contaminated soil. ► The traditional enrichment theory is not fully valid for PAHs. - The traditional enrichment theory is not fully valid for PAHs, and soil organic matters have a significant impact on the transport of PAHs during rainfall-runoff events.

  16. Self-Referential Processing in Adolescents: Stability of Behavioral and Event-Related Potential Markers

    Science.gov (United States)

    Auerbach, Randy P.; Bondy, Erin; Stanton, Colin H.; Webb, Christian A.; Shankman, Stewart A.; Pizzagalli, Diego A.

    2016-01-01

    The self-referential encoding task (SRET)—an implicit measure of self-schema—has been used widely to probe cognitive biases associated with depression, including among adolescents. However, research testing the stability of behavioral and electrocortical effects is sparse. Therefore, the current study sought to evaluate the stability of behavioral markers and event-related potentials (ERP) elicited from the SRET over time in healthy, female adolescents (n = 31). At baseline, participants were administered a diagnostic interview and a self-report measure of depression severity. In addition, they completed the SRET while 128-channel event-related potential (ERP) data were recorded to examine early (P1) and late (late positive potential [LPP]) ERPs. Three months later, participants were re-administered the depression self-report measure and the SRET in conjunction with ERPs. Results revealed that healthy adolescents endorsed, recalled, and recognized more positive and fewer negative words at each assessment, and these effects were stable over time (rs = 0.44–0.83). Similarly, they reported a faster reaction time when endorsing self-relevant positive words, as opposed to negative words, at both the initial and follow-up assessment (r = 0.82). Second, ERP responses, specifically potentiated P1 and late LPP positivity to positive versus negative words, were consistent over time (rs = 0.56–0.83), and the internal reliability of ERPs were robust at each time point (rs = 0.52–0.80). As a whole, these medium-to-large effects suggest that the SRET is a reliable behavioral and neural probe of self-referential processing. PMID:27302282

  17. Ultraviolet radiation-induced interleukin 6 release in HeLa cells is mediated via membrane events in a DNA damage-independent way.

    Science.gov (United States)

    Kulms, D; Pöppelmann, B; Schwarz, T

    2000-05-19

    Evidence exists that ultraviolet radiation (UV) affects molecular targets in the nucleus or at the cell membrane. UV-induced apoptosis was found to be mediated via DNA damage and activation of death receptors, suggesting that nuclear and membrane effects are not mutually exclusive. To determine whether participation of nuclear and membrane components is also essential for other UV responses, we studied the induction of interleukin-6 (IL-6) by UV. Exposing HeLa cells to UV at 4 degrees C, which inhibits activation of surface receptors, almost completely prevented IL-6 release. Enhanced repair of UV-mediated DNA damage by addition of the DNA repair enzyme photolyase did not affect UV-induced IL-6 production, suggesting that in this case membrane events predominant over nuclear effects. UV-induced IL-6 release is mediated via NFkappaB since the NFkappaB inhibitor MG132 or transfection of cells with a super-repressor form of the NFkappaB inhibitor IkappaB reduced IL-6 release. Transfection with a dominant negative mutant of the signaling protein TRAF-2 reduced IL-6 release upon exposure to UV, indicating that UV-induced IL-6 release is mediated by activation of the tumor necrosis factor receptor-1. These data demonstrate that UV can exert biological effects mainly by affecting cell surface receptors and that this is independent of its ability to induce nuclear DNA damage.

  18. The impact of cognitive behavioral therapy on post event processing among those with social anxiety disorder.

    Science.gov (United States)

    Price, Matthew; Anderson, Page L

    2011-02-01

    Individuals with social anxiety are prone to engage in post event processing (PEP), a post mortem review of a social interaction that focuses on negative elements. The extent that PEP is impacted by cognitive behavioral therapy (CBT) and the relation between PEP and change during treatment has yet to be evaluated in a controlled study. The current study used multilevel modeling to determine if PEP decreased as a result of treatment and if PEP limits treatment response for two types of cognitive behavioral treatments, a group-based cognitive behavioral intervention and individually based virtual reality exposure. These hypotheses were evaluated using 91 participants diagnosed with social anxiety disorder. The findings suggested that PEP decreased as a result of treatment, and that social anxiety symptoms for individuals reporting greater levels of PEP improved at a slower rate than those with lower levels of PEP. Further research is needed to understand why PEP attenuates response to treatment. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. The control of beads diameter of bead-on-string electrospun nanofibers and the corresponding release behaviors of embedded drugs

    Energy Technology Data Exchange (ETDEWEB)

    Li, Tingxiao [Key Laboratory of Textile Science and Technology (Donghua University), Ministry of Education of China, Shanghai 201620 (China); College of Textiles, Donghua University, Shanghai 201620 (China); Ding, Xin, E-mail: xding@dhu.edu.cn [Key Laboratory of Textile Science and Technology (Donghua University), Ministry of Education of China, Shanghai 201620 (China); College of Textiles, Donghua University, Shanghai 201620 (China); Tian, Lingling, E-mail: lingling_tian@nus.edu.sg [Center of Nanofibers & Nanotechnology, Department of Mechanical Engineering, National University of Singapore, 117576 (Singapore); Hu, Jiyong; Yang, Xudong [Key Laboratory of Textile Science and Technology (Donghua University), Ministry of Education of China, Shanghai 201620 (China); College of Textiles, Donghua University, Shanghai 201620 (China); Ramakrishna, Seeram [Center of Nanofibers & Nanotechnology, Department of Mechanical Engineering, National University of Singapore, 117576 (Singapore); Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou 510632 (China)

    2017-05-01

    Bead-on-string nanofibers, with appropriate control of the beads diameter, are potential fibrous structures for efficient encapsulation of particle drugs in micron scales and could achieve controlled drug release for tissue engineering applications. In this study, the beads diameter of electrospun bead-on-string nanofibers was controlled by adjusting the concentration of spinning polymer, poly (lactic-co-glycolic acid) (PLGA), and the solvent ratio of chloroform to acetone. The images of the scanning electron microscopy (SEM) suggested that bead-on-string nanofibers could be successfully obtained only with a certain range of PLGA solution concentration. Moreover, with the decrease in the solvent ratio of chloroform to acetone, the range was left-shifted towards a smaller concentration. In addition, increase in the PLGA solution concentration within the range the beads diameter became greater and the shape of the beads changed from oval to slender when increasing the PLGA concentration within the range. The bead-on-string nanofibers with different beads diameter were further used to load micro-particle drugs of tetracycline hydrochloride, as a model drug, to examine the release behavior of nanofibers scaffold. The release profiles of drug loaded bead-on-string nanofibers demonstrated the possibility to alleviate the burst drug release by means of beads diameter control. - Highlights: • Bead diameter of bead-on-string electrospun nanofibers was controlled by varying solvent ratio and polymer concentration. • The effect of the addition of particle drugs on BD of bead-on-string electrospun nanofibers was studied. • The corresponding release behaviors of nanofibers with different BD loading micro-particle drugs were investigated. • Bead-on-string nanofibers with bigger BD could alleviate the initial burst release.

  20. The control of beads diameter of bead-on-string electrospun nanofibers and the corresponding release behaviors of embedded drugs

    International Nuclear Information System (INIS)

    Li, Tingxiao; Ding, Xin; Tian, Lingling; Hu, Jiyong; Yang, Xudong; Ramakrishna, Seeram

    2017-01-01

    Bead-on-string nanofibers, with appropriate control of the beads diameter, are potential fibrous structures for efficient encapsulation of particle drugs in micron scales and could achieve controlled drug release for tissue engineering applications. In this study, the beads diameter of electrospun bead-on-string nanofibers was controlled by adjusting the concentration of spinning polymer, poly (lactic-co-glycolic acid) (PLGA), and the solvent ratio of chloroform to acetone. The images of the scanning electron microscopy (SEM) suggested that bead-on-string nanofibers could be successfully obtained only with a certain range of PLGA solution concentration. Moreover, with the decrease in the solvent ratio of chloroform to acetone, the range was left-shifted towards a smaller concentration. In addition, increase in the PLGA solution concentration within the range the beads diameter became greater and the shape of the beads changed from oval to slender when increasing the PLGA concentration within the range. The bead-on-string nanofibers with different beads diameter were further used to load micro-particle drugs of tetracycline hydrochloride, as a model drug, to examine the release behavior of nanofibers scaffold. The release profiles of drug loaded bead-on-string nanofibers demonstrated the possibility to alleviate the burst drug release by means of beads diameter control. - Highlights: • Bead diameter of bead-on-string electrospun nanofibers was controlled by varying solvent ratio and polymer concentration. • The effect of the addition of particle drugs on BD of bead-on-string electrospun nanofibers was studied. • The corresponding release behaviors of nanofibers with different BD loading micro-particle drugs were investigated. • Bead-on-string nanofibers with bigger BD could alleviate the initial burst release.

  1. Hot Experiment on Fission Gas Release Behavior from Voloxidation Process using Spent Fuel

    International Nuclear Information System (INIS)

    Park, Geun Il; Park, J. J.; Jung, I. H.; Shin, J. M.; Cho, K. H.; Yang, M. S.; Song, K. C.

    2007-08-01

    Quantitative analysis of the fission gas release characteristics during the voloxidation and OREOX processes of spent PWR fuel was carried out by spent PWR fuel in a hot-cell of the DFDF. The release characteristics of 85 Kr and 14 C fission gases during voloxidation process at 500 .deg. C is closely linked to the degree of conversion efficiency of UO 2 to U 3 O 8 powder, and it can be interpreted that the release from grain-boundary would be dominated during this step. Volatile fission gases of 14 C and 85 Kr were released to near completion during the OREOX process. Both the 14 C and 85 Kr have similar release characteristics under the voloxidation and OREOX process conditions. A higher burn-up spent fuel showed a higher release fraction than that of a low burn-up fuel during the voloxidation step at 500 .deg. C. It was also observed that the release fraction of semi-volatile Cs was about 16% during a reduction at 1,000 .deg. C of the oxidized powder, but over 90% during the voloxidation at 1,250 .deg. C

  2. Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making.

    Science.gov (United States)

    Papale, Andrew E; Zielinski, Mark C; Frank, Loren M; Jadhav, Shantanu P; Redish, A David

    2016-12-07

    Current theories posit that memories encoded during experiences are subsequently consolidated into longer-term storage. Hippocampal sharp-wave-ripple (SWR) events have been linked to this consolidation process during sleep, but SWRs also occur during awake immobility, where their role remains unclear. We report that awake SWR rates at the reward site are inversely related to the prevalence of vicarious trial and error (VTE) behaviors, thought to be involved in deliberation processes. SWR rates were diminished immediately after VTE behaviors and an increase in the rate of SWR events at the reward site predicted a decrease in subsequent VTE behaviors at the choice point. Furthermore, SWR disruptions increased VTE behaviors. These results suggest an inverse relationship between SWRs and VTE behaviors and suggest that awake SWRs and associated planning and memory consolidation mechanisms are engaged specifically in the context of higher levels of behavioral certainty. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Biodegradable polyesters for veterinary drug delivery systems: Characterization, in vitro degradation and release behavior of Oligolactides and Polytartrate

    OpenAIRE

    Schliecker, Gesine

    2004-01-01

    This thesis deals with the degradation and release behavior of aliphatic polyesters with special respect to the influence of oligomers on the degradation rate and the potential use of these biomaterials for the development of veterinary drug delivery systems. In Chapter 1 the animal health care market is introduced with regard to opportunities and challenges of veterinary drug delivery systems. . In the second part of this chapter...

  4. Three-dimensional, two-species magnetohydrodynamic studies of the early time behaviors of the Combined Release and Radiation Effects Satellite G2 barium release

    International Nuclear Information System (INIS)

    Xie, Lianghai; Li, Lei; Wang, Jingdong; Zhang, Yiteng

    2014-01-01

    We present a three-dimensional, two-species (Ba + and H + ) MHD model to study the early time behaviors of a barium release at about 1 R E like Combined Release and Radiation Effects Satellite G2, with emphasis placed on the three-dimensional evolution of the barium cloud and its effects on the ambient plasma environment. We find that the perturbations caused by the cloud are the combined results of the initial injection, the radial expansion, and the diamagnetic effect and propagate as fast MHD waves in the magnetosphere. In return, the transverse expansion and the cross-B motion of barium ions are constrained by the magnetic force, which lead to a field-aligned striation of ions and the decoupling of these ions from the neutrals. Our simulation shows the formation and collapse of the diamagnetic cavity in the barium cloud. The estimated time scale for the cavity evolution might be much shorter if photoionization time scale and field aligned expansion of barium ions are considered. In addition, our two species MHD simulation also finds the snowplow effect resulting from the momentum coupling between barium ions and background H + , which creates density hole and bumps in the background H + when barium ions expanding along the magnetic field lines

  5. Effects of modified surfaces produced at plasma-facing surface on hydrogen release behavior in the LHD

    Directory of Open Access Journals (Sweden)

    Y. Nobuta

    2017-08-01

    Full Text Available In the present study, an additional deuterium (D ion irradiation was performed against long-term samples mounted on the helical coil can and in the outer private region in the LHD during the 17th experimental campaign. Based on the release behavior of the D and hydrogen (H retained during the experimental campaign, the difference of release behavior at the top surface and in bulk of modified surfaces is discussed. Almost all samples on the helical coil can were erosion-dominant and some samples were covered with boron or carbon, while a very thick carbon films were formed in the outer private region. In the erosion-dominant area, the D desorbed at much lower temperatures compared to that of H retained during the LHD plasma operation. For the samples covered with boron, the D tended to desorb at lower temperatures compared to H. For the carbon deposition samples, the D desorbed at much higher temperatures compared to no deposition and boron-covered samples, which was very similar to that of H. The D retention capabilities at the top surface of carbon and boron films were 2–3 times higher than no deposition area. The results indicate that the retention and release behavior at the top surface of the modified layer can be different from that of bulk substrate material.

  6. In-Vitro Release of Ketoprofen Behavior Loaded in Polyvinyl Alcohol / Acrylamide Hydrogels Prepared by Gamma Irradiation

    International Nuclear Information System (INIS)

    Mahmoud, Gh.A.; Hegazy, D.E.; Kamal, H.

    2014-01-01

    Hydrogels based on various ratios of polyvinyl alcohol (PVA) and acrylamide (AAm) were prepared by gamma radiation. The formed hydrogels were characterized by spectroscopic analysis (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and swelling studied. It was found that the thermal stability of the hydrogel decreases as the AAm content increases in the hydrogel. The higher the AAm content in the hydrogel, the lower the values of Tm and ΔH m . Ketoprofen was adopted as a model drug to study the adsorption and release behavior of (PVA/AAm) hydrogel. The drug adsorption was decreased by increasing AAm ratio in the hydrogel. From the in vitro drug release study in ph progressive media, the basic medium was showed comparatively the highest release and the (PVA/AAm) hydrogel of composition (70/30) was found to be the highest release one. The mechanism of Ketoprofen release from the (PVA/AAm) matrix was found to be non-Fickian mechanism for all investigated hydrogels at ph 7.

  7. Quantifying Physiological, Behavioral and Ecological Consequences of Hypoxic Events in Kelp Forest

    Science.gov (United States)

    Litvin, S. Y.; Beers, J. M.; Woodson, C. B.; Leary, P.; Fringer, O. B.; Goldbogen, J. A.; Micheli, F.; Monismith, S. G.; Somero, G. N.

    2016-02-01

    Rocky reef kelp forests that extend along the coast of central California, like many habitats in upwelling systems, often experience inundations of low dissolved oxygen (DO) or hypoxic waters. These events have the potential to influence the structure and function of coastal ecosystems. The ecological consequences of hypoxia for these systems will be mediated by physiological thresholds and behavioral responses of resident organisms in the context of the spatial and temporal variability of DO, and other potential stressors. Our research focuses on Sebastes (i.e. rockfish) because of their commercial, recreational and ecological importance, high abundance across near shore habitats and the potentially severe impacts of physiological stress due to hypoxia. In the lab, to investigate how hypoxic events physiologically effect rockfish, we exposed young of the year (YOY) of 5 species and two life stages of blue rockfish, S. mystinus (YOY and 1+), to DO concentrations representative of upwelling conditions and measured a suite of whole organisms and tissue level responses including metabolic rate, ventilation, tissue-level metabolism, and blood biochemistry. Results demonstrate species and life stage specific differences in physiological stress under upwelling driven hypoxic conditions and suggest YOY rockfishes may currently be living near their physiological limits. In the laboratory we further explored if physiological impacts result in behavioral consequences by examining the startle response of YOY rockfish, a relative measure of predator avoidance ability, under a range of DO concentrations and exposure durations. To further explore behavioral responses of rockfish to low in DO within the kelp forest we are using two approaches, monitoring the vertical distribution of fish communities across the water column using an acoustic imaging camera (ARIS 3000, Soundmetrics Inc.) and acoustic tagging, with 3-D positioning ability (VPS, VEMCO Inc.), of larger blue rockfish

  8. [In vitro drug release behavior of carrier made of porous glass ceramics].

    Science.gov (United States)

    Wang, De-ping; Huang, Wen-hai; Zhou, Nai

    2002-09-01

    To conduct the in vitro test on drug release of rifampin encapsulated in a carrier made of porous phosphate glass ceramics and to analyze main factors which affect the drug release rate. A certain quantitative of rifampin was sealed in a hollow cylindrical capsule which consisted of chopped calcium phosphate crystal fiber obtained from glass crystallization. The rifampin concentration was measured in the simulated physiological solution in which the capsule soaked. Rifampin could be released in a constant rate from the porous glass ceramic carrier in a long time. The release rate was dependent on the size of crystal fiber and the wall thickness of the capsule. This kind of calcium phosphate glass ceramics can be a candidate of the carrier materials used as long term drug therapy after osteotomy surgery.

  9. Enrichment behavior and transport mechanism of soil-bound PAHs during rainfall-runoff events.

    Science.gov (United States)

    Zheng, Yi; Luo, Xiaolin; Zhang, Wei; Wu, Bin; Han, Feng; Lin, Zhongrong; Wang, Xuejun

    2012-12-01

    Polycyclic Aromatic Hydrocarbons (PAHs) transported by surface runoff result in nonpoint source pollution and jeopardize aquatic ecosystems. The transport mechanism of PAHs during rainfall-runoff events has been rarely studied regarding pervious areas. An experimental system was setup to simulate the runoff pollution process on PAHs-contaminated soil. The enrichment behavior of soil-bound PAHs was investigated. The results show that soil organic matters (SOM), rather than clay particles, seem to be the main carrier of PAHs. The enrichment is highly conditioned on runoff and erosion processes, and its magnitude varies among PAH compounds. It is not feasible to build a simple and universal relationship between enrichment ratio and sediment discharge following the traditional enrichment theory. To estimate the flux of PAHs from pervious areas, soil erosion process has to be clearly understood, and both organic carbon content and composition of SOM should be factored into the calculation. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Synthesis, characterization, and controlled release antibacterial behavior of antibiotic intercalated Mg–Al layered double hydroxides

    International Nuclear Information System (INIS)

    Wang, Yi; Zhang, Dun

    2012-01-01

    Graphical abstract: The antibiotic anion released from Mg–Al LDHs provides a controlled release antibacterial activity against the growth of Micrococcus lysodeikticus in 3.5% NaCl solution. Highlights: ► Antibiotic anion intercalated LDHs were synthesized and characterized. ► The ion-exchange one is responsible for the release process. ► The diffusion through particle is the release rate limiting step. ► LDHs loaded with antibiotic anion have high antibacterial capabilities. -- Abstract: Antibiotic–inorganic clay composites including four antibiotic anions, namely, benzoate (BZ), succinate (SU), benzylpenicillin (BP), and ticarcillin (TC) anions, intercalated Mg–Al layered double hydroxides (LDHs) were synthesized via ion-exchange. Powder X-ray diffraction and Fourier transform infrared spectrum analyses showed the successful intercalation of antibiotic anion into the LDH interlayer. BZ and BP anions were accommodated in the interlayer region as a bilayer, whereas SU and TC anions were intercalated in a monolayer arrangement. Kinetic simulation of the release data indicated that ion-exchange was responsible for the release process, and the diffusion through the particles was the rate-limiting step. The antibacterial capabilities of LDHs loaded with antibiotic anion toward Micrococcus lysodeikticus growth were analyzed using a turbidimetric method. Significant high inhibition rate was observed when LDH nanohybrid was introduced in 3.5% NaCl solution. Therefore, this hybrid material may be applied as nanocontainer in active antifouling coating for marine equipment.

  11. Drug Loading and Release Behavior Depending on the Induced Porosity of Chitosan/Cellulose Multilayer Nanofilms.

    Science.gov (United States)

    Park, Sohyeon; Choi, Daheui; Jeong, Hyejoong; Heo, Jiwoong; Hong, Jinkee

    2017-10-02

    The ability to control drug loading and release is the most important feature in the development of medical devices. In this research, we prepared a functional nanocoating technology to incorporate a drug-release layer onto a desired substrate. The multilayer films were prepared using chitosan (CHI) and carboxymethyl cellulose (CMC) polysaccharides by the layer-by-layer (LbL) method. By using chemical cross-linking to change the inner structure of the assembled multilayer, we could control the extent of drug loading and release. The cross-linked multilayer film had a porous structure and enhanced water wettability. Interestingly, more of the small-molecule drug was loaded into and released from the non-cross-linked multilayer film, whereas more of the macromolecular drug was loaded into and released from the cross-linked multilayer film. These results indicate that drug loading and release can be easily controlled according to the molecular weight of the desired drug by changing the structure of the film.

  12. Behavioral control blunts reactions to contemporaneous and future adverse events: Medial prefrontal cortex plasticity and a corticostriatal network

    Directory of Open Access Journals (Sweden)

    Steven F. Maier

    2015-01-01

    Full Text Available It has been known for many years that the ability to exert behavioral control over an adverse event blunts the behavioral and neurochemical impact of the event. More recently, it has become clear that the experience of behavioral control over adverse events also produces enduring changes that reduce the effects of subsequent negative events, even if they are uncontrollable and quite different from the original event controlled. This review focuses on the mechanism by which control both limits the impact of the stressor being experienced and produces enduring, trans-situational “immunization”. The evidence will suggest that control is detected by a corticostriatal circuit involving the ventral medial prefrontal cortex (mPFC and the posterior dorsomedial striatum (DMS. Once control is detected, other mPFC neurons that project to stress-responsive brainstem (dorsal raphe nucleus, DRN and limbic (amygdala structures exert top–down inhibitory control over the activation of these structures that is produced by the adverse event. These structures, such as the DRN and amygdala, in turn regulate the proximate mediators of the behavioral and physiological responses produced by adverse events, and so control blunts these responses. Importantly, the joint occurrence of control and adverse events seems to produce enduring plastic changes in the top–down inhibitory mPFC system such that this system is now activated by later adverse events even if they are uncontrollable, thereby reducing the impact of these events. Other issues are discussed that include a whether other processes such as safety signals and exercise, that lead to resistance/resilience, also use the mPFC circuitry or do so in other ways; b whether control has similar effects and neural mediation in humans, and c the relationship of this work to clinical phenomena.

  13. Exposure to suicidal behaviors: A common suicide risk factor or a personal negative life event?

    Science.gov (United States)

    Harris, Keith M; Bettiol, Silvana

    2017-02-01

    Numerous suicide risk factors have been proposed but not adequately validated for epidemiology, treatment and prevention efforts. Exposures to suicidal behaviors (ESB), from family and friend suicide attempts and completions, were tested for validity as a suicidal risk factor and also for measurement and construct adequacy. An anonymous online survey yielded 713 participants (aged 18-71), who reported ESB, completed the Suicidal Affect-Behavior-Cognition Scale (SABCS), and comprised a broad spectrum on those variables. Tests of dimensionality and internal consistency showed the four ESB variables (attempts/completions through family/friends) were independent and did not form a common factor or an identifiable ESB latent trait. ESB variables were, however, associated with demographic and psychiatric histories. A battery of tests revealed no meaningful associations between ESB and total suicidality or suicide risk factors (social support, depression, anxiety, stress, satisfaction with life and emotional stability). In addition, in contrast to previous reports, young adults ( n = 200; aged 18-20) showed no increased suicidality due to ESB. Results showed no validity for ESB as a common risk factor for suicidality or other psychopathology, or as a latent trait. ESB showed evidence as a personal negative life event with individual effects and interpretations.

  14. Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards.

    Science.gov (United States)

    Cameron, Courtney M; Wightman, R Mark; Carelli, Regina M

    2014-11-01

    Electrophysiological studies show that distinct subsets of nucleus accumbens (NAc) neurons differentially encode information about goal-directed behaviors for intravenous cocaine versus natural (food/water) rewards. Further, NAc rapid dopamine signaling occurs on a timescale similar to phasic cell firing during cocaine and natural reward-seeking behaviors. However, it is not known whether dopamine signaling is reinforcer specific (i.e., is released during responding for only one type of reinforcer) within discrete NAc locations, similar to neural firing dynamics. Here, fast-scan cyclic voltammetry (FSCV) was used to measure rapid dopamine release during multiple schedules involving sucrose reward and cocaine self-administration (n = 8 rats) and, in a separate group of rats (n = 6), during a sucrose/food multiple schedule. During the sucrose/cocaine multiple schedule, dopamine increased within seconds of operant responding for both reinforcers. Although dopamine release was not reinforcer specific, more subtle differences were observed in peak dopamine concentration [DA] across reinforcer conditions. Specifically, peak [DA] was higher during the first phase of the multiple schedule, regardless of reinforcer type. Further, the time to reach peak [DA] was delayed during cocaine-responding compared to sucrose. During the sucrose/food multiple schedule, increases in dopamine release were also observed relative to operant responding for both natural rewards. However, peak [DA] was higher relative to responding for sucrose than food, regardless of reinforcer order. Overall, the results reveal the dynamics of rapid dopamine signaling in discrete locations in the NAc across reward conditions, and provide novel insight into the functional role of this system in reward-seeking behaviors. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Release behavior and stability of encapsulated D-limonene from emulsion-based edible films.

    Science.gov (United States)

    Marcuzzo, Eva; Debeaufort, Frédéric; Sensidoni, Alessandro; Tat, Lara; Beney, Laurent; Hambleton, Alicia; Peressini, Donatella; Voilley, Andrée

    2012-12-12

    Edible films may act as carriers of active molecules, such as flavors. This possibility confers to them the status of active packaging. Two different film-forming biopolymers, gluten and ι-carrageenans, have been compared. D-Limonene was added to the two film formulations, and its release kinetics from emulsion-based edible films was assessed with HS-SPME. Results obtained for edible films were compared with D-limonene released from the fatty matrix called Grindsted Barrier System 2000 (GBS). Comparing ι-carrageenans with gluten-emulsified film, the latter showed more interesting encapsulating properties: in fact, D-limonene was retained by gluten film during the process needed for film preparation, and it was released gradually during analysis time. D-Limonene did not show great affinity to ι-carrageenans film, maybe due to high aroma compound hydrophobicity. Carvone release from the three different matrices was also measured to verify the effect of oxygen barrier performances of edible films to prevent D-limonene oxidation. Further investigations were carried out by FT-IR and liquid permeability measurements. Gluten film seemed to better protect D-limonene from oxidation. Gluten-based edible films represent an interesting opportunity as active packaging: they could retain and release aroma compounds gradually, showing different mechanical and nutritional properties from those of lipid-based ingredients.

  16. Estimation of in-plant source term release behaviors from Fukushima daiichi reactor cores by forward method and comparison with reverse method

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Won; Rhee, Bo Wook; Song, Jin Ho; Kim, Sung Il; Ha, Kwang Soon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2017-06-15

    The purpose of this paper is to confirm the event timings and the magnitude of fission product aerosol release from the Fukushima accident. Over a few hundreds of technical papers have been published on the environmental impact of Fukushima Daiichi accident since the accident occurred on March 11, 2011. However, most of the research used reverse or inverse method based on the monitoring of activities in the remote places and only few papers attempted to estimate the release of fission products from individual reactor core or from individual spent fuel pool. Severe accident analysis code can be used to estimate the radioactive release from which reactor core and from which radionuclide the peaks in monitoring points can be generated. The basic material used for this study are the initial core inventory obtained from the report JAEA-Data/Code 2012–018 and the given accident scenarios provided by Japanese Government or Tokyo Electric Power Company (TEPCO) in official reports. In this research a forward method using severe accident progression code is used as it might be useful for justifying the results of reverse or inverse method or vice versa. The release timing and amounts to the environment are estimated for volatile radioactive fission products such as noble gases, cesium, iodine, and tellurium up to 184 hours (about 7.7 days) after earthquake occurs. The in-plant fission product behaviors and release characteristics to environment are estimated using the severe accident progression analysis code, MELCOR, for Fukushima Daiichi accident. These results are compared with other research results which are summarized in UNSCEAR 2013 Report and other technical papers. Also it may provide the physically based arguments for justifying or suspecting the rationale for the scenarios provided in open literature. The estimated results by MELCOR code simulation of this study indicate that the release amount of volatile fission products to environment from Units 1, 2, and 3

  17. Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

    DEFF Research Database (Denmark)

    Boutrup Stephansen, Karen; García-Díaz, María; Jessen, Flemming

    2016-01-01

    , and drug delivery. In the present study, we present a systematic investigation of how surfactants and proteins, as physiologically relevant components, interact with insulin-loaded fish sarcoplasmic protein (FSP) electrospun fibers (FSP-Ins fibers) in solution and thereby affect fiber properties...... such as accessible surface hydrophilicity, physical stability, and release characteristics of an encapsulated drug. Interactions between insulin-loaded protein fibers and five anionic surfactants (sodium taurocholate, sodium taurodeoxycholate, sodium glycocholate, sodium glycodeoxycholate, and sodium dodecyl sulfate......), a cationic surfactant (benzalkonium chloride), and a neutral surfactant (Triton X-100) were studied. The anionic surfactants increased the insulin release in a concentration-dependent manner, whereas the neutral surfactant had no significant effect on the release. Interestingly, only minute amounts...

  18. Process behavior and environmental assessment of 14C releases from an HTGR fuel reprocessing facility

    International Nuclear Information System (INIS)

    Snider, J.W.; Kaye, S.V.

    1976-01-01

    Large quantities of 14 CO 2 will be evolved when graphite fuel blocks are burned during reprocessing of spent fuel from HTGR reactors. The possible release of some or all of this 14 C to the environment is a matter of concern which is investigated in this paper. Various alternatives are considered in this study for decontaminating and releasing the process off-gas to the environment. Concomitant radiological analyses have been done for the waste process scenarios to supply the necessary feedbacks for process design

  19. Evaluation of tritium release behavior from Li{sub 2}TiO{sub 3} during DT neutron irradiation by use of an improved tritium collection method

    Energy Technology Data Exchange (ETDEWEB)

    Edao, Yuki, E-mail: edao.yuki@jaea.go.jp [Tritium Technology Group, Department of Blanket Systems Research, Rokkasho Fusion Institute, Sector of Fusion Research and Development, Japan Atomic Energy Agency, 2-4 Shirane Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1195 (Japan); Kawamura, Yoshinori [Blanket Technology Group, Department of Blanket Systems Research, Rokkasho Fusion Institute, Sector of Fusion Research and Development, Japan Atomic Energy Agency, 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan); Hoshino, Tsuyoshi [Breeding Functional Materials Development Group, Department of Blanket Systems Research, Rokkasho Fusion Institute, Sector of Fusion Research and Development, Japan Atomic Energy Agency, 2-166 Omotedate Obuchi, Rokkasho, Aomori 039-3212 (Japan); Ochiai, Kentaro [BA Project Coordination Group, Department of Fusion Power Systems Research, Rokkasho Fusion Institute, Sector of Fusion Research and Development, Japan Atomic Energy Agency, 2-166 Omotedate Obuchi, Rokkasho, Aomori 039-3212 (Japan)

    2016-11-15

    Highlights: • Behavior of tritium released from Li{sub 2}TiO{sub 3} under neutron irradiation was measured. • Tritium collection method with hydrophobic catalyst was demonstrated successfully. • Temperature of Li{sub 2}TiO{sub 3} was dominant to control the chemical form of tritium release. - Abstract: The accurate measurement of behavior of bred tritium released from a tritium breeder is indispensable to understand the behavior for a design of a tritium extraction system. The tritium collection method combined a CuO bed and water bubbles was not suitable to measure transient behavior of tritium released from Li{sub 2}TiO{sub 3} during neutron irradiation because tritium released behavior was changed to be delayed due to adsorption of oxidized tritium on the CuO. Hence, the tritium collection method with hydrophobic catalyst instead of the CuO was demonstrated and succeeded the accurate release measurement of tritium from Li{sub 2}TiO{sub 3}. With the method, we assessed the behavior of tritium release under the various conditions since tritium should be released from Li{sub 2}TiO{sub 3} as the form of HT as much as possible from the view point of the fuel cycle. Our results indicated; promotion of isotopic exchange reaction on the surface of Li{sub 2}TiO{sub 3} by addition of hydrogen in sweep gas is mandatory in order to release tritium smoothly from Li{sub 2}TiO{sub 3} irradiated with neutrons; the favorable sweep gas to release as the form of HT was hydrogen added inert gas; and the temperature of Li{sub 2}TiO{sub 3} was the dominant parameter to control the chemical form of tritium released from the Li{sub 2}TiO{sub 3}.

  20. Preparation of ionic-crosslinked chitosan-based gel beads and effect of reaction conditions on drug release behaviors.

    Science.gov (United States)

    Chen, Shilan; Liu, Mingzhu; Jin, Shuping; Wang, Bin

    2008-02-12

    Drug-loaded chitosan (CS) beads were prepared under simple and mild condition using trisodium citrate as ionic crosslinker. The beads were further coated with poly(methacrylic acid) (PMAA) by dipping the beads in PMAA aqueous solution. The surface and cross-section morphology of these beads were observed by scanning electron microscopy and the observation showed that the coating beads had core-shell structure. In vitro release of model drug from these beads obtained under different reaction conditions was investigated in buffer medium (pH 1.8). The results showed that the rapid drug release was restrained by PMAA coating and the optimum conditions for preparing CS-based drug-loaded beads were decided through the effect of reaction conditions on the drug release behaviors. In addition, the drug release mechanism of CS-based drug-loaded beads was analyzed by Peppa's potential equation. According to this study, the ionic-crosslinked CS beads coated by PMAA could serve as suitable candidate for drug site-specific carrier in stomach.

  1. Preliminary investigation of the potential for transient vapor release events during in situ vitrification based on thermal- hydraulic modeling

    International Nuclear Information System (INIS)

    Roberts, J.S.; Woosley, S.L.; Lessor, D.L.; Strachan, C.

    1992-07-01

    This study investigates a possible cause of molten glass displacements that occurred during two recent in situ vitrification (ISV) tests. The study was conducted for the US Department of Energy by Pacific Northwest Laboratory. It is hypothesized that these glass displacements are caused by large gas bubbles rising up through the ISV melt and bursting at its surface. These bubbles cause the molten surface to upwell and possibly overflow. When the bubbles burst, molten glass is thrown from the melt surface and the volume of gas contained in the bubble is released into the hood. Both of these phenomena are undesirable because the molten soil ejected from the melt is dangerous to operating personnel and can damage equipment. The sudden gas release can cause a temporary pressurization of the hood, allowing potentially contaminated gas to escape to the atmosphere. This study attempts to explain the conditions necessary for formation of large gas bubbles in the melt so that future glass displacements can be avoided

  2. Preliminary investigation of the potential for transient vapor release events during in situ vitrification based on thermal- hydraulic modeling

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, J.S.; Woosley, S.L.; Lessor, D.L.; Strachan, C.

    1992-07-01

    This study investigates a possible cause of molten glass displacements that occurred during two recent in situ vitrification (ISV) tests. The study was conducted for the US Department of Energy by Pacific Northwest Laboratory. It is hypothesized that these glass displacements are caused by large gas bubbles rising up through the ISV melt and bursting at its surface. These bubbles cause the molten surface to upwell and possibly overflow. When the bubbles burst, molten glass is thrown from the melt surface and the volume of gas contained in the bubble is released into the hood. Both of these phenomena are undesirable because the molten soil ejected from the melt is dangerous to operating personnel and can damage equipment. The sudden gas release can cause a temporary pressurization of the hood, allowing potentially contaminated gas to escape to the atmosphere. This study attempts to explain the conditions necessary for formation of large gas bubbles in the melt so that future glass displacements can be avoided.

  3. Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivo.

    Science.gov (United States)

    Aiba, Isamu; Carlson, Andrew P; Sheline, Christian T; Shuttleworth, C William

    2012-02-01

    Cortical spreading depression (CSD) is a consequence of a slowly propagating wave of neuronal and glial depolarization (spreading depolarization; SD). Massive release of glutamate contributes to SD propagation, and it was recently shown that Zn(2+) is also released from synaptic vesicles during SD. The present study examined consequences of extracellular Zn(2+) accumulation on the propagation of SD. SD mechanisms were studied first in murine brain slices, using focal KCl applications as stimuli and making electrical and optical recordings in hippocampal area CA1. Elevating extracellular Zn(2+) concentrations with exogenous ZnCl(2) reduced SD propagation rates. Selective chelation of endogenous Zn(2+) (using TPEN or CaEDTA) increased SD propagation rates, and these effects appeared due to chelation of Zn(2+) derived from synaptic vesicles. Thus, in tissues where synaptic Zn(2+) release was absent [knockout (KO) of vesicular Zn(2+) transporter ZnT-3], SD propagation rates were increased, and no additional increase was observed following chelation of endogenous Zn(2+) in these tissues. The role of synaptic Zn(2+) was then examined on CSD in vivo. ZnT-3 KO animals had higher susceptibility to CSD than wild-type controls as evidenced by significantly higher propagation rates and frequencies. Studies of candidate mechanisms excluded changes in neuronal excitability, presynaptic release, and GABA receptors but left open a possible contribution of N-methyl-d-aspartate (NMDA) receptor inhibition. These results suggest the extracellular accumulation of synaptically released Zn(2+) can serve as an intrinsic inhibitor to limit SD events. The inhibitory action of extracellular Zn(2+) on SD may counteract to some extent the neurotoxic effects of intracellular Zn(2+) accumulation in acute brain injury models.

  4. GRSIS program to predict fission gas release and swelling behavior of metallic fast reactor fuel

    International Nuclear Information System (INIS)

    Lee, Chan Bock; Lee, Byung Ho; Nam, Cheol; Sohn, Dong Seong

    1999-03-01

    A mechanistic model of fission gas release and swelling for the U-(Pu)-Zr metallic fuel in the fast reactor, GRSIS (Gas Release and Swelling in ISotropic fuel matrix) was developed. Fission gas bubbles are assumed to nucleate isotropically from the gas atoms in the metallic fuel matrix since they can nucleate at both the grain boundaries and the phase boundaries which are randomly distributed inside the grain. Bubbles can grow to larger size by gas diffusion and coalition with other bubbles so that they are classified as three classes depending upon their sizes. When bubble swelling reaches the threshold value, bubbles become interconnected each other to make the open channel to the external free space, that is, the open bubbles and then fission gases inside the interconnected open bubbles are released instantaneously. During the irradiation, fission gases are released through the open bubbles. GRSIS model can take into account the fuel gap closure by fuel bubble swelling. When the fuel gap is closed by fuel swelling, the contact pressure between fuel and cladding in relation to the bubble swelling and temperature is calculated. GRSIS model was validated by comparison with the irradiation test results of U-(Pu)-Zr fuels in ANL as well as the parametric studies of the key variable in the model. (author). 13 refs., 1 tab., 22 figs

  5. GRSIS program to predict fission gas release and swelling behavior of metallic fast reactor fuel

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chan Bock; Lee, Byung Ho; Nam, Cheol; Sohn, Dong Seong

    1999-03-01

    A mechanistic model of fission gas release and swelling for the U-(Pu)-Zr metallic fuel in the fast reactor, GRSIS (Gas Release and Swelling in ISotropic fuel matrix) was developed. Fission gas bubbles are assumed to nucleate isotropically from the gas atoms in the metallic fuel matrix since they can nucleate at both the grain boundaries and the phase boundaries which are randomly distributed inside the grain. Bubbles can grow to larger size by gas diffusion and coalition with other bubbles so that they are classified as three classes depending upon their sizes. When bubble swelling reaches the threshold value, bubbles become interconnected each other to make the open channel to the external free space, that is, the open bubbles and then fission gases inside the interconnected open bubbles are released instantaneously. During the irradiation, fission gases are released through the open bubbles. GRSIS model can take into account the fuel gap closure by fuel bubble swelling. When the fuel gap is closed by fuel swelling, the contact pressure between fuel and cladding in relation to the bubble swelling and temperature is calculated. GRSIS model was validated by comparison with the irradiation test results of U-(Pu)-Zr fuels in ANL as well as the parametric studies of the key variable in the model. (author). 13 refs., 1 tab., 22 figs.

  6. In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

    DEFF Research Database (Denmark)

    Sun, Ming; Chen, Muwan; Wang, Miao

    2016-01-01

    Bone tissue-engineered scaffolds with therapeutic effects must meet the basic requirements as to support bone healing at the defect side and to release an effect drug within the therapeutic window. Here, a rapid prototyped PCL scaffold embedded with chitosan/nanoclay/β-tricalcium phosphate...

  7. Balance and behavior of gaseous radionuclides released during initial fast reactor fuel reprocessing operations

    International Nuclear Information System (INIS)

    Leudet, A.; Goumondy, J.P.; Charrier, G.

    1985-10-01

    Five pins from the fast reactor Phenix are cut and dissolved in a specially designed cell for the accurate determination of gas released during the operation. Amount and activity of gaseous radionuclides: Kr, Xe, Kr-85, I, I-129, H-3 and C-14 are determined in the fuel pins and also their distribution between shearing and dissolution [fr

  8. Phosphorus release behaviors of poultry litter biochar as a soil amendment

    International Nuclear Information System (INIS)

    Wang, Yue; Lin, Yingxin; Chiu, Pei C.; Imhoff, Paul T.; Guo, Mingxin

    2015-01-01

    Phosphorus (P) may be immobilized and consequently the runoff loss risks be reduced if poultry litter (PL) is converted into biochar prior to land application. Laboratory studies were conducted to examine the water extractability of P in PL biochar and its release kinetics in amended soils. Raw PL and its biochar produced through 400 °C pyrolysis were extracted with deionized water under various programs and measured for water extractable P species and contents. The materials were further incubated with a sandy loam at 20 g kg −1 soil and intermittently leached with water for 30 days. The P release kinetics were determined from the P recovery patterns in the water phase. Pyrolysis elevated the total P content from 13.7 g kg −1 in raw PL to 27.1 g kg −1 in PL biochar while reduced the water-soluble P level from 2.95 g kg −1 in the former to 0.17 g kg −1 in the latter. The thermal treatment transformed labile P in raw PL to putatively Mg/Ca phosphate minerals in biochar that were water-unextractable yet proton-releasable. Orthophosphate was the predominant form of water-soluble P in PL biochar, with condensed phosphate (e.g., pyrophosphate) as a minor form and organic phosphate in null. Release of P from PL biochar in both water and neutral soils was at a slower and steadier rate over a longer time period than from raw PL. Nevertheless, release of P from biochar was acid-driven and could be greatly promoted by the media acidity. Land application of PL biochar at soil pH-incorporated rates and frequency will potentially reduce P losses to runoffs and minimize the adverse impact of waste application on aquatic environments. - Highlights: • The predominant portion of P in poultry litter biochar is water insoluble. • Poultry litter P was immobilized by forming Ca/Mg (pyro)phosphates in biochar. • Release of P from biochar was slower and steadier than from raw poultry litter. • Soil pH greatly influenced the P release patterns of poultry litter biochar

  9. Phosphorus release behaviors of poultry litter biochar as a soil amendment

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yue [Department of Civil and Environmental Engineering, University of Delaware, Newark, DE 19716 (United States); Lin, Yingxin [Department of Agriculture and Natural Resources, Delaware State University, Dover, DE 19901 (United States); Chiu, Pei C.; Imhoff, Paul T. [Department of Civil and Environmental Engineering, University of Delaware, Newark, DE 19716 (United States); Guo, Mingxin, E-mail: mguo@desu.edu [Department of Agriculture and Natural Resources, Delaware State University, Dover, DE 19901 (United States)

    2015-04-15

    Phosphorus (P) may be immobilized and consequently the runoff loss risks be reduced if poultry litter (PL) is converted into biochar prior to land application. Laboratory studies were conducted to examine the water extractability of P in PL biochar and its release kinetics in amended soils. Raw PL and its biochar produced through 400 °C pyrolysis were extracted with deionized water under various programs and measured for water extractable P species and contents. The materials were further incubated with a sandy loam at 20 g kg{sup −1} soil and intermittently leached with water for 30 days. The P release kinetics were determined from the P recovery patterns in the water phase. Pyrolysis elevated the total P content from 13.7 g kg{sup −1} in raw PL to 27.1 g kg{sup −1} in PL biochar while reduced the water-soluble P level from 2.95 g kg{sup −1} in the former to 0.17 g kg{sup −1} in the latter. The thermal treatment transformed labile P in raw PL to putatively Mg/Ca phosphate minerals in biochar that were water-unextractable yet proton-releasable. Orthophosphate was the predominant form of water-soluble P in PL biochar, with condensed phosphate (e.g., pyrophosphate) as a minor form and organic phosphate in null. Release of P from PL biochar in both water and neutral soils was at a slower and steadier rate over a longer time period than from raw PL. Nevertheless, release of P from biochar was acid-driven and could be greatly promoted by the media acidity. Land application of PL biochar at soil pH-incorporated rates and frequency will potentially reduce P losses to runoffs and minimize the adverse impact of waste application on aquatic environments. - Highlights: • The predominant portion of P in poultry litter biochar is water insoluble. • Poultry litter P was immobilized by forming Ca/Mg (pyro)phosphates in biochar. • Release of P from biochar was slower and steadier than from raw poultry litter. • Soil pH greatly influenced the P release patterns

  10. Negative online word-of-mouth: Behavioral indicator or emotional release?

    NARCIS (Netherlands)

    Verhagen, T.; Nauta, A.; Feldberg, J.F.M.

    2013-01-01

    The influence of negative online word-of-mouth on the behavior of those receiving it has been addressed extensively in the academic literature. Remarkably, the question whether negative online word-of-mouth should also be seen as a behavioral indicator of its sender remains unaddressed. Answering

  11. Synthesis, characterization, and controlled release anticorrosion behavior of benzoate intercalated Zn-Al layered double hydroxides

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yi [Shandong Provincial Key Lab of Corrosion Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071 (China); Zhang, Dun, E-mail: zhangdun@qdio.ac.cn [Shandong Provincial Key Lab of Corrosion Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071 (China)

    2011-11-15

    Graphical abstract: The benzoate anion released from Zn-Al LDHs provides a more effective long-term protection against corrosion of Q235 carbon steel in 3.5% NaCl solution. Highlights: {yields} A benzoate anion corrosion inhibitor intercalated Zn-Al layered double hydroxides (LDHs) has been assembled by coprecipitation method. {yields} The kinetic simulation indicates that the ion-exchange one is responsible for the release process and the diffusion through particle is the rate limiting step. {yields} A significant reduction of the corrosion rate is observed when the LDH nanohybrid is present in the corrosive media. -- Abstract: Corrosion inhibitor-inorganic clay composite including benzoate anion intercalated Zn-Al layered double hydroxides (LDHs) are assembled by coprecipitation. Powder X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectrum analyses indicate that the benzoate anion is successfully intercalated into the LDH interlayer and the benzene planes are vertically bilayer-positioned as a quasi-guest ion-pair form in the gallery space. Kinetic simulation for the release data, XRD and FT-IR analyses of samples recovered from the release medium indicate that ion-exchange is responsible for the release process and diffusion through the particle is also indicated to be the rate-limiting step. The anticorrosion capabilities of LDHs loaded with corrosion inhibitor toward Q235 carbon steel are analyzed by polarization curve and electrochemical impedance spectroscopy methods. Significant reduction of corrosion rate is observed when the LDH nanohybrid is present in the corrosive medium. This hybrid material may potentially be applied as a nanocontainer in self-healing coatings.

  12. Release behavior of fission products from irradiated dispersion fuels at high temperatures

    International Nuclear Information System (INIS)

    Iwai, Takashi; Shimizu, Michio; Nakagawa, Tetsuya

    1990-02-01

    As a framework of reduced enrichment fuel program of JMTR Project, the measurements of fission products release rates at high temperatures (600degC - 1100degC) were performed in order to take the data to use for safety evaluation of LEU fuel. Three type miniplates of dispersion silicide and aluminide fuel, 20% enrichment LEU fuel with 4.8 gU/cc (U 3 Si 2 90 %, USi 10 % and U 3 Si 2 50 %, U 3 Si 50 % dispersed in aluminium) and 45 % enrichment MEU fuel with 1.6 gU/cc, were irradiated in JMTR. The burnups attained by one cycle (22 days) irradiation were within 21.6 % - 22.5 % of initial 235 U. The specimens cut down from miniplates were measured on fission products release rates by means of new apparatus specially designed for this experiment. The specimens were heated up within 600degC - 1100degC in dry air. Then fission products such as 85 Kr, 133 Xe, 131 I, 137 Cs, 103 Ru, 129m Te were collected at each temperature and measured on release rates. In the results of measurement, the release rates of 85 Kr, 133 Xe, 131 I, 129m Te from all specimens were slightly less than that of G.W. Parker's data on U-Al alloy fuel. For 137 Cs and 103 Ru from a silicide specimen (U 3 Si 2 90 %, USi 10 % dispersed in aluminium) and 137 Cs from an aluminide specimen, the release rates were slightly higher than that of G.W. Parker's. (author)

  13. Behaviors and Conditions that Challenge Teamwork: An Assessment of Operating Events at U.S. Commercial Nuclear Power Plants

    International Nuclear Information System (INIS)

    Desaulniers, David R.

    1998-01-01

    As part of its regulatory activities, the U.S. Nuclear Regulatory Commission (NRC) reviews events and routine activities at commercial nuclear power facilities throughout the United States. Frequently, these reviews have highlighted team performance as an important factor in either the initiation or mitigation of significant events and conditions at these facilities. This paper summarizes operating experience relevant to the understanding of teamwork at U.S. nuclear power plants during recent years, describes the specific behaviors that were considered detrimental to team performance, and discusses the conditions that were identified as contributing to these behaviors. (author)

  14. Minor corral changes and adoption of good handling practices can improve the behavior and reduce cortisol release in Nellore cows.

    Science.gov (United States)

    Lima, Maria Lúcia Pereira; Negrão, João Alberto; de Paz, Claudia Cristina Paro; Grandin, Temple

    2018-03-01

    Inadequate corral facilities and improper handling are major causes of stress in beef cattle. The purpose of this study was to evaluate the effects of minor changes in the corral and adoption of good handling practices on the behavior, cortisol release, and time spent taking blood samples in Nellore cows. Minor corral changes included obstructing the cow's vision when the handler walked deep into the animal's flight zone and the elimination of bright objects, color contrasts, puddles, shadows, and darkness in the corral. Handling was improved by eliminating dogs, electric goads (prods), and yelling, as well as adopting a calm behavior. A total of 141 Nellore cows from two typical extensive livestock farms were studied. The cows were evaluated individually before and after the corral changes. Blood samples were collected in the restraint device for cortisol measurement. The minor corral changes and the adoption of good handling practices result in better results for all variables studied. The results showed differences in the interactions between treatment and ranch for chute score (P = 0.0091) and exit score (P good handling practices were effective in improving cow behavior in the chute and in reducing exit velocity, cortisol released, and the time spent taking blood samples.

  15. Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions.

    LENUS (Irish Health Repository)

    Cahill, Ronan A

    2012-02-03

    BACKGROUND: Peritoneal injury sustained at laparotomy may evoke local inflammatory responses that result in adhesion formation. Peritoneal mast cells are likely to initiate this process, whereas vascular permeability\\/endothelial growth factor (VEGF) may facilitate the degree to which subsequent adhesion formation occurs. METHODS: Mast cell deficient mice (WBB6F1-\\/-), along with their mast cell sufficient counterparts (WBB6F1+\\/+), underwent a standardized adhesion-inducing operation (AIS) with subsequent sacrifice and adhesion assessment 14 days later in a blinded fashion. Additional CD-1 and WBB6F1+\\/+, and WBB6F1-\\/- mice were killed 2, 6, 12, and 24 hours after operation for measurement of VEGF by ELISA in systemic serum and peritoneal lavage fluid. Two further groups of CD-1 mice underwent AIS and received either a single perioperative dose of anti-VEGF monoclonal antibody (10 mug\\/mouse) or a similar volume of IgG isotypic antibody and adhesion formation 2 weeks later was evaluated. RESULTS: WBB6F1-\\/- mice had less adhesions then did their WBB6F1+\\/+ counterparts (median [interquartile range] adhesion score 3[3-3] vs 1.5[1-2] respectively; P < .003). Local VEGF release peaked 6 hours after AIS in both WBB6F1+\\/+ and CD-1 mice whereas levels remained at baseline in WBB6F1-\\/- mice. CD-1 mice treated with a single dose of anti-VEGF therapy during operation had less adhesions than controls (2[1.25-2] vs 3[2.25-3], P = .0002). CONCLUSIONS: Mast cells and VEGF are central to the formation of postoperative intra-abdominal adhesions with mast cells being responsible, either directly or indirectly, for VEGF release into the peritoneal cavity after operation. In tandem with the recent clinical success of anti-VEGF monoclonal antibodies in oncologic practice, our observations suggest an intriguing avenue for research and development of anti-adhesion strategy.

  16. Behavior of strontium-90 and cesium-137 released into the pond of Office of Atomic Energy for Peace

    International Nuclear Information System (INIS)

    Milintawisamai, Mesak; Panyathipsakul, Yureeporn

    1989-01-01

    Strontium-90 and cesium-137 in liquid waste released from the waste disposal plant of Office of Atomic Energy for Peace(OAEP) have been followed since 1984. The concentration of both nuclides in surface water outside OAEP boundary is 2 to 30 times less than in the OAEP pond, the reservoir of liquid waste. This indicates that most of the nuclides are effectively absorbed by clay in the bottom of the pond. The nuclide concentration in fresh-water organisms in the pond such as fish, prawn and snail is also investigated to elucidate the behavior of strontium-90 and cesium-137 in a static fresh-water ecological system

  17. Adequate Measuring Technology and System of Fission Gas release Behavior from Voloxidation Process

    International Nuclear Information System (INIS)

    Park, Geun Il; Park, J. J.; Jung, I. H.; Shin, J. M.; Yang, M. S.; Song, K. C.

    2006-09-01

    Based on the published literature and an understanding of available hot cell technologies, more accurate measuring methods for each volatile fission product released from voloxidation process were reviewed and selected. The conceptual design of an apparatus for measuring volatile and/or semi-volatile fission products released from spent fuel was prepared. It was identified that on-line measurement techniques can be applied for gamma-emitting fission products, and off-line measurement such as chemical/or neutron activation analysis can applied for analyzing beta-emitting fission gases. Collection methods using appropriate material or solutions were selected to measure the release fraction of beta-emitting gaseous fission products at IMEF M6 hot cell. Especially, the on-line gamma-ray counting system for monitoring of 85Kr and the off-line measuring system of 14C was established. On-line measuring system for obtaining removal ratios of the semi-volatile fission products, mainly gamma-emitting fission products such as Cs, Ru etc., was also developed at IMEF M6 hot cell which was based on by measuring fuel inventory before and after the voloxidation test through gamma measuring technique. The development of this measurement system may enable basic information to be obtained to support design of the off-gas treatment system for the voloxidation process at INL, USA

  18. Analysis of vertical stability limits and vertical displacement event behavior on NSTX-U

    Science.gov (United States)

    Boyer, Mark; Battaglia, Devon; Gerhardt, Stefan; Menard, Jonathan; Mueller, Dennis; Myers, Clayton; Sabbagh, Steven; Smith, David

    2017-10-01

    The National Spherical Torus Experiment Upgrade (NSTX-U) completed its first run campaign in 2016, including commissioning a larger center-stack and three new tangentially aimed neutral beam sources. NSTX-U operates at increased aspect ratio due to the larger center-stack, making vertical stabilization more challenging. Since ST performance is improved at high elongation, improvements to the vertical control system were made, including use of multiple up-down-symmetric flux loop pairs for real-time estimation, and filtering to remove noise. Similar operating limits to those on NSTX (in terms of elongation and internal inductance) were achieved, now at higher aspect ratio. To better understand the observed limits and project to future operating points, a database of vertical displacement events and vertical oscillations observed during the plasma current ramp-up on NSTX/NSTX-U has been generated. Shots were clustered based on the characteristics of the VDEs/oscillations, and the plasma parameter regimes associated with the classes of behavior were studied. Results provide guidance for scenario development during ramp-up to avoid large oscillations at the time of diverting, and provide the means to assess stability of target scenarios for the next campaign. Results will also guide plans for improvements to the vertical control system. Work supported by U.S. D.O.E. Contract No. DE-AC02-09CH11466.

  19. GABAergic influences on ORX receptor-dependent abnormal motor behaviors and neurodegenerative events in fish

    International Nuclear Information System (INIS)

    Facciolo, Rosa Maria; Crudo, Michele; Giusi, Giuseppina; Canonaco, Marcello

    2010-01-01

    At date the major neuroreceptors i.e. γ-aminobutyric acid A (GABA A R) and orexin (ORXR) systems are beginning to be linked to homeostasis, neuroendocrine and emotional states. In this study, intraperitoneal treatment of the marine teleost Thalassoma pavo with the highly selective GABA A R agonist (muscimol, MUS; 0,1 μg/g body weight) and/or its antagonist bicuculline (BIC; 1 μg/g body weight) have corroborated a GABA A ergic role on motor behaviors. In particular, MUS induced moderate (p A R was very likely responsible for very strong and strong ORXR mRNA reductions in cerebellum valvula and torus longitudinalis, respectively. Moreover these effects were linked to evident ultra-structural changes such as shrunken cell membranes and loss of cytoplasmic architecture. In contrast, MUS supplied a very low, if any, argyrophilic reaction in hypothalamic and mesencephalic regions plus a scarce level of ultra-structural damages. Interestingly, combined administrations of MUS + BIC were not related to consistent damages, aside mild neuronal alterations in motor-related areas such as optic tectum. Overall it is tempting to suggest, for the first time, a neuroprotective role of GABA A R inhibitory actions against the overexcitatory ORXR-dependent neurodegeneration and consequently abnormal swimming events in fish.

  20. Fluoxetine Alleviates Behavioral Depression while Decreasing Acetylcholine Release in the Nucleus Accumbens Shell

    OpenAIRE

    Chau, David T; Rada, Pedro V; Kim, Kay; Kosloff, Rebecca A; Hoebel, Bartley G

    2011-01-01

    Selective serotonin reuptake inhibitors, such as fluoxetine, have demonstrated the ability to alleviate behavioral depression in the forced swim test; however, the sites and mechanisms of their actions remain to be further elucidated. Previous studies have suggested that behavioral depression in the swim test is mediated in part by acetylcholine (ACh) stimulating the cholinergic M1 receptors in the nucleus accumbens (NAc) shell. The current study tested whether acute, local, and chronic, subc...

  1. Sedimentary evidence for enhanced hydrological cycling in response to rapid carbon release during the early Toarcian oceanic anoxic event

    Science.gov (United States)

    Izumi, Kentaro; Kemp, David B.; Itamiya, Shoma; Inui, Mutsuko

    2018-01-01

    A pronounced excursion in the carbon-isotope composition of biospheric carbon and coeval seawater warming during the early Toarcian (∼183 Ma) has been linked to the large-scale transfer of 12C-enriched carbon to the oceans and atmosphere. A European bias in the distribution of available data means that the precise pattern, tempo and global expression of this carbon cycle perturbation, and the associated environmental responses, remain uncertain. Here, we present a new cm-scale terrestrial-dominated carbon-isotope record through an expanded lower Toarcian section from Japan that displays a negative excursion pattern similar to marine and terrestrial carbon-isotope records documented from Europe. These new data suggest that 12C-enriched carbon was added to the biosphere in at least one rapid, millennial-scale pulse. Sedimentological analysis indicates a close association between the carbon-isotope excursion and high-energy sediment transport and enhanced fluvial discharge. Together, these data support the hypothesis that a sudden strengthening of the global hydrological cycle occurred in direct and immediate response to rapid carbon release and atmospheric warming.

  2. Behavior and movement of formerly landlocked juvenile coho salmon after release into the free-flowing Cowlitz River, Washington

    Science.gov (United States)

    Kock, Tobias J.; Henning, Julie A.; Liedtke, Theresa L.; Royer, Ida M.; Ekstrom, Brian K.; Rondorf, Dennis W.

    2011-01-01

    Formerly landlocked Coho Salmon (Oncorhynchus kisutch) juveniles (age 2) were monitored following release into the free-flowing Cowlitz River to determine if they remained in the river or resumed seaward migration. Juvenile Coho Salmon were tagged with a radio transmitter (30 fish) or Floy tag (1050 fish) and their behavior was monitored in the lower Cowlitz River. We found that 97% of the radio-tagged fish remained in the Cowlitz River beyond the juvenile outmigration period, and the number of fish dispersing downstream decreased with increasing distance from the release site. None of the tagged fish returned as spawning adults in the 2 y following release. We suspect that fish in our study failed to migrate because they exceeded a threshold in size, age, or physiological status. Tagged fish in our study primarily remained in the Cowlitz River, thus it is possible that these fish presented challenges to juvenile salmon migrating through the system either directly by predation or indirectly by competition for food or habitat. Given these findings, returning formerly landlocked Coho Salmon juveniles to the free-flowing river apparently provided no benefit to the anadromous population. These findings have management implications in locations where landlocked salmon have the potential to interact with anadromous species of concern.

  3. Balance and behavior of gaseous radionuclides released during initial PWR fuel reprocessing operations

    International Nuclear Information System (INIS)

    Leudet, A.; Miquel, P.; Goumondy, P.J.; Charrier, G.

    1982-08-01

    Five fuel pins, taken from a PWR fuel assembly with 32000 MWD/t burn-up were chopped and dissolved in leak-proof equipment designed for accurate determination of the composition and quantity of gaseous elements released in these operations. Analytical methods were specially developped to determine directly the noble gases, tritium and gaseous carbon compounds in the gas phase. Volatile iodine was kept as close as possible to the source by cold traps, then transferred to a caustic solution for quantitative analysis. The quantities and activities of gaseous fission products thus determined were compared with predicted values obtained through computation. Very good agreement was generally observed

  4. Balance and behavior of gaseous radionuclides released during initial PWR fuel reprocessing operations

    International Nuclear Information System (INIS)

    Leudet, A.; Miquel, P.; Goumondy, P.J.; Charrier, G.

    1983-01-01

    Five fuel pins, taken from a PWR fuel assembly with 32,000 MwD/t burn-up were chopped and dissolved in leak-proof equipment designed for accurate determination of the composition and quantity of gaseous elements released in these operations. Analytical methods were specially developed to determine directly the noble gases, tritium and gaseous carbon compounds in the gas phase. Volatile iodine was kept as close as possible to the source by cold traps, then transferred to a caustic solution for quantitative analysis. The quantities and activities of gaseous fission products thus determined were compared with predicted values obtained through computation. Very good agreement was generally observed

  5. Mutual event observations of solar system objects by SRC on Mars Express. Analysis and release of observations

    Science.gov (United States)

    Ziese, R.; Willner, K.

    2018-06-01

    Context. Both Martian moons, Phobos and Deimos, have been observed during several imaging campaigns by the Super Resolution Channel (SRC) on the Mars Express probe. Several tens of images are obtained during mutual event observations - when the Martian moons are both observed or together with another solar system body. These observations provide new opportunities to determine the bodies' positions in their orbits. Aims: A method was sought to automate the observation of the positions of the imaged bodies. Within one image sequence a similarly accurate localization of the objects in all images should be possible. Methods: Shape models of Phobos and Deimos are applied to simulate the appearance of the bodies in the images. Matching the illuminated simulation against the observation provides a reliable determination of the bodies' location within the image. To enhance the matching confidence several corrections need to be applied to the simulation to closely reconstruct the observation. Results: A list of 884 relative positions between the different objects is provided through the Centre de Données astronomiques de Strasbourg (CDS). Tables A.1-A.4 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/614/A15

  6. Release Behavior and Antibacterial Activity of Chitosan/Alginate Blends with Aloe vera and Silver Nanoparticles.

    Science.gov (United States)

    Gómez Chabala, Luisa Fernanda; Cuartas, Claudia Elena Echeverri; López, Martha Elena Londoño

    2017-10-24

    Aloe vera is a perennial plant employed for medical, pharmaceutical and cosmetic purposes that is rich in amino acids, enzymes, vitamins and polysaccharides, which are responsible for its therapeutic properties. Incorporating these properties into a biopolymer film obtained from alginate and chitosan allowed the development of a novel wound dressing with antibacterial capacity and healing effects to integrate the antibacterial capacity of silver nanoparticles with the healing and emollient properties of Aloe vera gel. Three alginate-chitosan matrices were obtained through blending methods using different proportions of alginate, chitosan, the Aloe vera (AV) gel and silver nanoparticles (AgNps), which were incorporated into the polymeric system through immersion methods. Physical, chemical and antibacterial characteristics were evaluated in each matrix. Interaction between alginate and chitosan was identified using the Fourier transform infrared spectroscopy technique (FTIR), porosity was studied using scanning electron microscopy (SEM), swelling degree was calculated by difference in weight, Aloe vera gel release capacity was estimated by applying a drug model (Peppas) and finally antibacterial capacity was evaluated against S. Aureus and P. aeruginosa . Results show that alginate-chitosan (A (1:3 Chit 1/Alg 1); B (1:3 Chit 1.5/Alg 1) and C (3:1 Chit 1/Alg 1/B12)) matrices with Aloe vera (AV) gel and silver nanoparticles (AgNps) described here displayed antibacterial properties and absorption and Aloe vera release capacity making it a potential wound dressing for minor injuries.

  7. Event-Related Potential Measures of Attention Capture in Adolescent Inpatients With Acute Suicidal Behavior.

    Science.gov (United States)

    Tavakoli, Paniz; Boafo, Addo; Dale, Allyson; Robillard, Rebecca; Greenham, Stephanie L; Campbell, Kenneth

    2018-01-01

    Impaired executive functions, modulated by the frontal lobes, have been suggested to be associated with suicidal behavior. The present study examines one of these executive functions, attentional control, maintaining attention to the task-at-hand. A group of inpatient adolescents with acute suicidal behavior and healthy controls were studied using a passively presented auditory optimal paradigm. This "optimal" paradigm consisted of a series of frequently presented homogenous pure tone "standards" and different "deviants," constructed by changing one or more features of the standard. The optimal paradigm has been shown to be a more time-efficient replacement to the traditional oddball paradigm, which makes it suitable for use in clinical populations. The extent of processing of these "to-be-ignored" auditory stimuli was measured by recording event-related potentials (ERPs). The P3a ERP component is thought to reflect processes associated with the capturing of attention. Rare and novel stimuli may result in an executive decision to switch attention away from the current cognitive task and toward a probe of the potentially more relevant "interrupting" auditory input. On the other hand, stimuli that are quite similar to the standard should not elicit P3a. The P3a has been shown to be larger in immature brains in early compared to later adolescence. An overall enhanced P3a was observed in the suicidal group. The P3a was larger in this group for both the environmental sound and white noise deviants, although only the environmental sound P3a attained significance. Other deviants representing only a small change from the standard did not elicit a P3a in healthy controls. They did elicit a small P3a in the suicidal group. These findings suggest a lowered threshold for the triggering of the involuntary switch of attention in these patients, which may play a role in their reported distractibility. The enhanced P3a is also suggestive of an immature frontal central executive

  8. Behavioral activation for dementia caregivers: scheduling pleasant events and enhancing communications

    Directory of Open Access Journals (Sweden)

    Au A

    2015-03-01

    Full Text Available Alma Au,1,2 Dolores Gallagher-Thompson,3 Meng-Kong Wong,4 Jess Leung,4 Wai-Chi Chan,5 Chun Chung Chan,6 Hui-Jing Lu,1 Man Kin Lai,1 Kevin Chan11Department of Applied Social Sciences, 2Institute of Active Aging, The Hong Kong Polytechnic University, Hong Kong, People’s Republic of China; 3Department of Psychiatry and Behavioral Sciences and Geriatric Education Centre, School of Medicine, Stanford University, Stanford, CA, USA; 4Department of Psychiatry, United Christian Hospital, 5Department of Psychiatry, University of Hong Kong, 6Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, People’s Republic of ChinaBackground: Dementia caregiving is often associated with increase in depressive symptoms and strained relationships. This study tested whether telephone-delivered psychoeducation combined with an enhanced behavioral activation (BA module had a better effect on the well-being of Alzheimer’s caregivers than psychoeducation alone. The focus is on enhancing the competent use of coping skills via BA. The program is delivered by telephone to increase accessibility and sustainability for caregivers. Senior citizens are trained as paraprofessionals to deliver the BA module to increase the potential for sustainability of the program.Methods and subjects: The study compared two telephone interventions using a 4-month longitudinal randomized controlled trial. For the first 4 weeks, all participants received the same psychoeducation program via telephone. Then for the following 4 months, eight biweekly telephone follow-up calls were carried out. For these eight follow-up calls, participants were randomized into either one of the two following groups with different conditions. For the psychoeducation with BA (PsyED-BA group, participants received eight biweekly sessions of BA practice focused on pleasant event scheduling and improving communications. For the psychoeducation only (PsyED only group, participants received

  9. Event-Related Potential Measures of Attention Capture in Adolescent Inpatients With Acute Suicidal Behavior

    Directory of Open Access Journals (Sweden)

    Paniz Tavakoli

    2018-03-01

    Full Text Available Impaired executive functions, modulated by the frontal lobes, have been suggested to be associated with suicidal behavior. The present study examines one of these executive functions, attentional control, maintaining attention to the task-at-hand. A group of inpatient adolescents with acute suicidal behavior and healthy controls were studied using a passively presented auditory optimal paradigm. This “optimal” paradigm consisted of a series of frequently presented homogenous pure tone “standards” and different “deviants,” constructed by changing one or more features of the standard. The optimal paradigm has been shown to be a more time-efficient replacement to the traditional oddball paradigm, which makes it suitable for use in clinical populations. The extent of processing of these “to-be-ignored” auditory stimuli was measured by recording event-related potentials (ERPs. The P3a ERP component is thought to reflect processes associated with the capturing of attention. Rare and novel stimuli may result in an executive decision to switch attention away from the current cognitive task and toward a probe of the potentially more relevant “interrupting” auditory input. On the other hand, stimuli that are quite similar to the standard should not elicit P3a. The P3a has been shown to be larger in immature brains in early compared to later adolescence. An overall enhanced P3a was observed in the suicidal group. The P3a was larger in this group for both the environmental sound and white noise deviants, although only the environmental sound P3a attained significance. Other deviants representing only a small change from the standard did not elicit a P3a in healthy controls. They did elicit a small P3a in the suicidal group. These findings suggest a lowered threshold for the triggering of the involuntary switch of attention in these patients, which may play a role in their reported distractibility. The enhanced P3a is also suggestive of

  10. Evaluating the Effect of Nuclear Power Plant Buildings on the Atmospheric Dispersion Behavior of Released Radioactive Materials

    International Nuclear Information System (INIS)

    Nassar, N.N.; Tawfik, F.S.; Agamy, S.A.; Nagla, T.F.

    2017-01-01

    One of the most important principles in air pollution is to minimize the release of pollutants to the atmosphere, deposition on the ground and promote sufficient dilution of released pollutants within the atmosphere. Building down wash describes the effect that wind flowing over or around buildings create a cavity of reticulating winds in the are a near the buildings. These cavities cause increased vertical dispersion of plumes emitted from stacks on or near the buildings . Often it leads to elevated concentrations downwind of affected stacks. The aim of this work is to evaluate the effect of the building down wash phenomena on the atmospheric dispersion behavior of released radioactive materials from NPP. In this study, a hypothetical scenario is presented involving a point source with varying stack parameters and rectangular shaped buildings (Mille stone Nuclear Power Plant) using meteorological parameters of a chosen day. The concentrations of assumed released radionuclides, taking into consideration the building down wash effect and without are calculated using the AERMOD Model taking into consideration the effect of the type of atmospheric stability class. Also the analysis includes the model predictions for the highest 1-hour cavity concentration. The results show that the size of the cavity zone is not affected by the type of stability class, but is affected by the stack location and buildings shape. On other hand, the distance at which the plume touches the ground is affected by the type of stability class, the stack location and buildings shape. So, strategies for locating buildings need to be considered to maximize dispersion when planning for constructing several reactors and accessory buildings at a nuclear site

  11. Social connectedness, stressful life events, and self-injurious thoughts and behaviors among young adults.

    Science.gov (United States)

    Macrynikola, Natalia; Miranda, Regina; Soffer, Ariella

    2018-01-01

    Preventing self-injurious thoughts and behaviors (SITBs) is particularly challenging on commuter campuses, given lower social cohesion and higher levels of stress than among traditional college populations. The present study examined the relationship between stressful life events (SLEs) and risk for different forms of SITBs, along with the potential buffering role of social connectedness, in a diverse sample of young adults from a commuter college. Participants were 1712 (81% female; 61% racial/ethnic minority; 20% sexual minority) undergraduate and graduate students from a public commuter college in New York City. Participants completed an anonymous survey that inquired about lifetime and recent (past 12months) history of suicidal ideation, suicide attempts, and non-suicidal self-injury (NSSI), along with social connectedness and lifetime history of SLEs. Lower levels of social connectedness and exposure to a higher number of SLEs were associated with engaging in SITBs in the past year, particularly both suicide attempts and non-suicidal self-injury. However, social connectedness did not buffer against the impact of SLEs on SITBs. Data are cross-sectional, limiting conclusions about directionality, and females were overrepresented. Identifying ways to increase social connectedness on diverse commuter campuses may help decrease risk of SITBs. However, it may not buffer against the impact of SLEs on risk of SITBs. Future studies should examine contextual variables (e.g., type and timing of social support) that may play a role in protecting against SITBs, particularly for those with a history of adversity. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties

    DEFF Research Database (Denmark)

    Boutrup Stephansen, Karen; García-Díaz, María; Jessen, Flemming

    2016-01-01

    , and drug delivery. In the present study, we present a systematic investigation of how surfactants and proteins, as physiologically relevant components, interact with insulin-loaded fish sarcoplasmic protein (FSP) electrospun fibers (FSP-Ins fibers) in solution and thereby affect fiber properties...... such as accessible surface hydrophilicity, physical stability, and release characteristics of an encapsulated drug. Interactions between insulin-loaded protein fibers and five anionic surfactants (sodium taurocholate, sodium taurodeoxycholate, sodium glycocholate, sodium glycodeoxycholate, and sodium dodecyl sulfate......Intermolecular interaction phenomena occurring between endogenous compounds, such as proteins and bile salts, and electrospun compounds are so far unreported, despite the exposure of fibers to such biorelevant compounds when applied for biomedical purposes, e.g., tissue engineering, wound healing...

  13. Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors.

    Science.gov (United States)

    Bagley, Elena E; Hacker, Jennifer; Chefer, Vladimir I; Mallet, Christophe; McNally, Gavan P; Chieng, Billy C H; Perroud, Julie; Shippenberg, Toni S; Christie, MacDonald J

    2011-10-30

    Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly increased GABAergic neuronal excitability and synaptic GABA release in the periaqueductal gray (PAG) during opioid withdrawal in rodents. In contrast, GAT-1 did not indirectly alter GABA receptor responses via modulation of extracellular GABA concentrations. Notably, we found that GAT-1-induced increases in GABAergic activity contributed to many PAG-mediated signs of opioid withdrawal. Together, these data support the hypothesis that GAT-1 activity directly produces opioid withdrawal signs through direct hyperexcitation of GABAergic PAG neurons and nerve terminals, which presumably enhances GABAergic inhibition of PAG output neurons. These data provide, to the best of our knowledge, the first evidence that dysregulation of a neurotransmitter transporter current is important for the maladaptive plasticity that underlies opiate withdrawal.

  14. Oxygenated gasoline release in the unsaturated zone - Part 1: Source zone behavior.

    Science.gov (United States)

    Freitas, Juliana G; Barker, James F

    2011-11-01

    Oxygenates present in gasoline, such as ethanol and MTBE, are a concern in subsurface contamination related to accidental spills. While gasoline hydrocarbon compounds have low solubility, MTBE and ethanol are more soluble, ethanol being completely miscible with water. Consequently, their fate in the subsurface is likely to differ from that of gasoline. To evaluate the fate of gasoline containing oxygenates following a release in the unsaturated zone shielded from rainfall/recharge, a controlled field test was performed at Canadian Forces Base Borden, in Ontario. 200L of a mixture composed of gasoline with 10% ethanol and 4.5% MTBE was released in the unsaturated zone, into a trench 20cm deep, about 32cm above the water table. Based on soil cores, most of the ethanol was retained in the source, above the capillary fringe, and remained there for more than 100 days. Ethanol partitioned from the gasoline to the unsaturated pore-water and was retained, despite the thin unsaturated zone at the site (~35cm from the top of the capillary fringe to ground surface). Due to its lower solubility, most of the MTBE remained within the NAPL as it infiltrated deeper into the unsaturated zone and accumulated with the gasoline on top of the depressed capillary fringe. Only minor changes in the distribution of ethanol were noted following oscillations in the water table. Two methods to estimate the capacity of the unsaturated zone to retain ethanol are explored. It is clear that conceptual models for sites impacted by ethanol-fuels must consider the unsaturated zone. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Peer pressure on the riverbank: Assessing catch-and-release anglers' willingness to sanction others' (bad) behavior.

    Science.gov (United States)

    Guckian, Meaghan L; Danylchuk, Andy J; Cooke, Steven J; Markowitz, Ezra M

    2018-08-01

    Given the well-documented impacts of angler behavior on the biological fitness of angled and released fish, optimizing the conservation value of catch-and-release angling hinges on the extent to which anglers are willing to adopt recommended best practices and refrain from harmful ones. One potentially powerful mechanism underlying adoption of best practices is the social pressure anglers can apply to one another to enforce community norms and values. Past work in other domains demonstrates that forms of interpersonal communication-including social sanctioning-can foster context-appropriate social norms and increase cooperative behavior; yet to date, little research has examined these dynamics in the context of species conservation. We conducted in-person and online surveys to explore the role of social sanctioning in the context of an internationally renowned wild steelhead (Oncorhynchus mykiss) fishery in British Columbia, Canada. We investigated how diverse social-psychological and demographic factors influence anglers' past and future sanctioning propensity. Results highlight that perceived capacity to influence the angling practices of others and professed concerns about one's own reputation were strongly predictive of both past and future sanctioning. Furthermore, while anglers reported relatively low-levels of past sanctioning behavior, most anglers simultaneously expressed a strong desire to sanction others in the future. Identifying ways to increase the social desirability and visibility of sanctioning actions could assist resource managers in promoting adoption and maintenance of best practices. More broadly, our findings underscore a significant yet underappreciated role for wildlife users and enthusiasts in cultivating a shared conservation ethic to help ensure biological conservation. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. Stimulation of the medial amygdala enhances medial preoptic dopamine release: implications for male rat sexual behavior.

    Science.gov (United States)

    Dominguez, J M; Hull, E M

    2001-11-02

    Increased dopamine (DA) in the medial preoptic area (MPOA) facilitates male sexual behavior. A major source of innervation to the MPOA is the medial amygdala (MeA). We now report that chemical stimulation of the MeA enhanced levels of extracellular MPOA DA in anesthetized male rats. These results suggest that DA activity in the MPOA can be regulated by input from the MeA to the MPOA.

  17. Event-related potentials reveal early attention bias for negative, unexpected behavior

    OpenAIRE

    Jerónimo, R.; Volpert, H. I.; Bartholow, B. D.

    2017-01-01

    WOS:000395098000012 (Nº de Acesso Web of Science) Numerous studies have documented that expectancy-violating (EV) behavior (i.e., behavior that violates existing person impressions) elicits more effortful cognitive processing compared to expectancy-consistent (EC) behavior. Some studies also have shown that this effect is modulated by the valence of behavior, though this finding is inconsistent with some extant models of expectancy processes. The current research investigated whether the v...

  18. Down the Rabbit Hole: toward appropriate discussion of methane release from gas hydrate systems during the Paleocene-Eocene thermal maximum and other past hyperthermal events

    Directory of Open Access Journals (Sweden)

    G. R. Dickens

    2011-08-01

    Full Text Available Enormous amounts of 13C-depleted carbon rapidly entered the exogenic carbon cycle during the onset of the Paleocene-Eocene thermal maximum (PETM, as attested to by a prominent negative carbon isotope (δ13C excursion and deep-sea carbonate dissolution. A widely cited explanation for this carbon input has been thermal dissociation of gas hydrate on continental slopes, followed by release of CH4 from the seafloor and its subsequent oxidation to CO2 in the ocean or atmosphere. Increasingly, papers have argued against this mechanism, but without fully considering existing ideas and available data. Moreover, other explanations have been presented as plausible alternatives, even though they conflict with geological observations, they raise major conceptual problems, or both. Methane release from gas hydrates remains a congruous explanation for the δ13C excursion across the PETM, although it requires an unconventional framework for global carbon and sulfur cycling, and it lacks proof. These issues are addressed here in the hope that they will prompt appropriate discussions regarding the extraordinary carbon injection at the start of the PETM and during other events in Earth's history.

  19. Implantable biodegradable sponges: effect of interpolymer complex formation of chitosan with gelatin on the release behavior of tramadol hydrochloride.

    Science.gov (United States)

    Foda, Nagwa H; El-laithy, Hanan M; Tadros, Mina I

    2007-01-01

    The effect of interpolymer complex formation between positively charged chitosan and negatively charged gelatin (Type B) on the release behavior of tramadol hydrochloride from biodegradable chitosan-gelatin sponges was studied. Mixed sponges were prepared by freeze-drying the cross-linked homogenous stable foams produced from chitosan and gelatin solutions where gelatin acts as a foam builder. Generation of stable foams was optimized where concentration, pH of gelatin solution, temperature, speed and duration of whipping process, and, chitosan-gelatin ratio drastically affect the properties and the stability of the produced foams. The prepared sponges were evaluated for their morphology, drug content, and microstructure using scanning electron microscopy, mechanical properties, uptake capacity, drug release profile, and their pharmacodynamic activity in terms of the analgesic effect after implantation in Wistar rats. It was revealed that whipping 7% (w/w) gelatin solution, of pH 5.5, for 15 min at 25 degrees C with a stirring speed of 1000 rpm was the optimum conditions for stable gelatin foam generation. Moreover, homogenous, uniform chitosan-gelatin foam with small air bubbles were produced by mixing 2.5% w/w chitosan solution with 7% w/w gelatin solution in 1:5 ratio. Indeed, polyionic complexation between chitosan and gelatin overcame the drawbacks of chitosan sponge mechanical properties where, pliable, soft, and compressible sponge with high fluid uptake capacity was produced at 25 degrees C and 65% relative humidity without any added plasticizer. Drug release studies showed a successful retardation of the incorporated drug where the t50% values of the dissolution profiles were 0.55, 3.03, and 4.73 hr for cross-linked gelatin, un-cross-linked chitosan-gelatin, and cross-linked chitosan-gelatin sponges, respectively. All the release experiments followed Higuchi's diffusion mechanism over 12 hr. The achieved drug prolongation was a result of a combined effect

  20. Fluoxetine Alleviates Behavioral Depression while Decreasing Acetylcholine Release in the Nucleus Accumbens Shell

    Science.gov (United States)

    Chau, David T; Rada, Pedro V; Kim, Kay; Kosloff, Rebecca A; Hoebel, Bartley G

    2011-01-01

    Selective serotonin reuptake inhibitors, such as fluoxetine, have demonstrated the ability to alleviate behavioral depression in the forced swim test; however, the sites and mechanisms of their actions remain to be further elucidated. Previous studies have suggested that behavioral depression in the swim test is mediated in part by acetylcholine (ACh) stimulating the cholinergic M1 receptors in the nucleus accumbens (NAc) shell. The current study tested whether acute, local, and chronic, subcutaneous fluoxetine treatments increase escape motivation during the swim test while simultaneously lowering extracellular ACh in the NAc shell. Experiment 1: Fluoxetine (1.0 mM) infused unilaterally in the NAc shell for 40 min reduced extracellular ACh while simultaneously increasing swimming time. Experiment 2: Fluoxetine (0.2, 0.5, and 0.75 mM) infused bilaterally in the NAc shell on day 3 dose-dependently decreased immobility and increased the total escape attempts (swimming and climbing) compared with Ringer given on day 2. Experiment 3: Fluoxetine (0.5 mM) infused bilaterally in the NAc for 40 min did not affect activities in an open field. Experiment 4: Chronic systemic fluoxetine treatment decreased immobility scores and increased total escape attempt scores compared with control saline treatment. In all, 14 days after the initial swim test, basal extracellular ACh in the shell was still elevated in the saline-treated group, but not in the fluoxetine-treated group. In summary, these data suggest that one of the potential mechanisms by which fluoxetine alleviates behavioral depression in the forced swim test may be to suppress cholinergic activities in the NAc shell. PMID:21525864

  1. Creep rupture behavior of polypropylene suture material and its applications as a time-release mechanism

    International Nuclear Information System (INIS)

    Kusy, R.P.; Whitley, J.Q.

    1983-01-01

    The controlled failure of polypropylene (PP) sutures is studied via creep rupture tests. From plots of log time (tB) vs. stress (sigma), linear relationships are generated over the failure times of 1-1000 h. Results show that as a function of stress, the time dependence varies with irradiation dose (15, 20, 25, and 50 Mrad), irradiation atmosphere (air and vacuum), suture diameter (7-0, 6-0, 5-0, and 4-0), and test temperature (26 and 37 degrees C). For a given stress, the time to failure is least for the greatest dose in the presence of air and at the highest temperature. When suture loops are wrapped around a small wire sheave, however, failure occurs in the largest suture as much as two decades sooner than the smallest suture studied. Within the limitations stated herein, they are independent of test method, loop diameter, aging, and humidity. Consequently, after irradiation in vacuum and postirradiation heat treatment, the processed material may be stored at room temperature for at least 1 month. Such materials are advocated when the time release of a dental or medical device is required, for example, in the self-activating cleft palate appliance

  2. Spot the difference: engineered and natural nanoparticles in the environment--release, behavior, and fate.

    Science.gov (United States)

    Wagner, Stephan; Gondikas, Andreas; Neubauer, Elisabeth; Hofmann, Thilo; von der Kammer, Frank

    2014-11-10

    The production and use of nanoparticles leads to the emission of manufactured or engineered nanoparticles into the environment. Those particles undergo many possible reactions and interactions in the environment they are exposed to. These reactions and the resulting behavior and fate of nanoparticles in the environment have been studied for decades through naturally occurring nanoparticulate (1-100 nm) and colloidal (1-1000 nm) substances. The knowledge gained from these investigations is nowhere near sufficiently complete to create a detailed model of the behavior and fate of engineered nanoparticles in the environment, but is a valuable starting point for the risk assessment of these novel materials. It is the aim of this Review to critically compare naturally observed processes with those found for engineered systems to identify the "nanospecific" properties of manufactured particles and describe critical knowledge gaps relevant for the risk assessment of manufactured nanomaterials in the environment. © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

  3. BEHAVIOR RELATIONSHIP MOTHER AND OWNERSHIP OF TOILET FAMILIES WITH CHILDREN EVENTS

    Directory of Open Access Journals (Sweden)

    eti kurniawati

    2016-06-01

    Full Text Available Ascariasis incidence in children under five in the region work of Puskesmas Olak Kemang still a health problem that needs to be addressed, with a percentage of 51.0% is higher than in other wilayh. The disease is not lethal but can undermine the health of the human body so that the resulting decline in nutritional status, decreased intelligence and brain power or immune health in children.               This research is a quantitative study using descriptive analytic method with cross sectional study design that aims to determine the relationship between the independent variables and the dependent variable. The population in this research that all children under five in the area of Puskesmas Olak Kemang, samples in this study were 75 children under five. Data were analyzed using analysis Univariate and Bivariate analysis with Chi-Square Test.               The results showed that 78.0% of mothers of children under five who are not air personal hygiene, 60.4% of mothers of children under five unusual CTPS, 82.1% of respondents who did not state house meliliki latrine / WC. The results of the bivariate analysis showed that there was a significant relationship between personal hygiene (p-value = 0.000, customs CTPS (p-value = 0.001, latrine ownership (p-value = 0.000 with the incidence of intestinal worms in Puskesmas Olak Kemang Jambi.               In connection with the results obtained, that the danger of de- worming is dependent on the cleanliness of his mother in serving as personal hygiene, CTPS and Owners toilets in every home. Thus the researchers suggested that the health center may be able to provide information to the public education about the dangers of de- worming to create a healthy society. Keyword                     :  Behavior, Children Events

  4. The influence of HIV disease events/stages on smoking attitudes and behaviors: project STATE (Study of Tobacco Attitudes and Teachable Events).

    Science.gov (United States)

    Vidrine, Damon J; Fletcher, Faith E; Buchberg, Meredith K; Li, Yisheng; Arduino, Roberto C; Gritz, Ellen R

    2014-02-11

    Given the increase in life expectancy among HIV-positive individuals attributable to antiretroviral therapies, cigarette smoking now represents one of the most salient health risks confronting the HIV-positive population. Despite this risk, very few efforts to date have been made to target persons living with HIV for smoking cessation treatment, and no efforts have been made to explore the role of cognitions and HIV disease events/stages on smoking outcomes. The purpose of the study, Project STATE (Study of Tobacco Attitudes and Teachable Events), is to prospectively examine the relationship between HIV events/stages, perceived impact of HIV disease, attitudes about cigarette smoking, and smoking behaviors. This study employs a prospective design. Patients are recruited at the time of their first physician visit at a large inner city HIV-clinic--Thomas Street Health Center (TSHC). Consenting participants then complete a baseline assessment. All participants are offered standard care smoking cessation treatment. Follow-up assessments are completed on four subsequent occasions: 3, 6, 9, and 12 months post-baseline. These follow-up assessments are scheduled to coincide with routine clinic appointments with their TSHC physicians. In addition, each participant is given a prepaid cell phone at the time of enrollment and asked to complete brief phone assessments weekly for the first three months of the study period. By evaluating events/stages of HIV disease as potential teaching moments for smoking cessation, findings from this study could be used to develop treatments tailored to an individual's stage of HIV disease. This study design will enable us to carefully track changes in smoking behavior over time, and to link these changes to both the course of HIV disease and/or to the participant's' perceived impact of HIV. By identifying optimal time points for intervention, the findings from this study will have the potential to maximize the efficiency and efficacy of

  5. Irradiated fuel behavior under accident heating conditions and correlation with fission gas release and swelling model (Chicago)

    International Nuclear Information System (INIS)

    Kryger, B.; Ducamp, F.; Combette, P.

    1981-08-01

    We analyse the mixed oxide fast fuel response to off normal conditions obtained by means of an out-of-pile transient simulation apparatus designed to provide direct observations (temperature, pressure, fuel motion) of fuel fission gas phenomena that might occur during the transients. The results are concerning fast transient tests (0,1 to 1 second) obtained with high gas concentration irradiated fuel (4 to 7 at % burn up, 0,4 cm 3 Xe + Kr /g.UPuO 2 ). The kinetics of fission gas release during the transients have been directly measured and then compared with the calculated results issued of the Chicago model. This model agrees, quite well, with other experiments done in the silene prompt reactor. Other gases than xenon and krypton (such as hydrogen and carbon monoxide) do not play any role in fuel behavior, since they have been completely ruled out

  6. Behavior and Release of Nitrogen at Mines and Quarries in Nordic Conditions

    Science.gov (United States)

    Karlsson, Teemu; Neitola, Raisa; Jermakka, Johannes; Merta, Elina; Mroueh, Ulla-Maija

    2015-04-01

    The increased extraction of mineral resources and mining activities creates added pressure on the environmental issues and a proper water management in mining areas in Finland. Among others, nitrogen compounds released from explosives or from mining processes can have a detrimental effect on the environment. Thus, this project aimed at comprehensive understanding on the nitrogen issue in the extractive industry. The project collected essential data on nitrogen compounds present in the environments of mines and quarries, and generated better understanding of the discharge and behaviour of nitrogen compounds in mining areas. The sources and balances of explosives-originated nitrogen compounds at mines and quarries of different sizes were investigated and compared. Additionally, the focus was in 'nitrogen smudging' problem of waste rocks and the intensity, as well as evolution and chemical characteristics of their nitrogen contamination. According to the results, the total load of potential nitrogen to the environment depends on the scale and type of the activity as well as the type of explosives used. The main emission sources of nitrogen are process and dewatering waters. A lysimeter study showed that the explosives originated nitrogen content of left over stones from natural stone quarrying is relatively low and ca. half of the nitrogen is leached within the first weeks after detonation. The "nitrogen smudging" of natural stone quarrying left over stones is relatively low to begin with and enhanced by the rapid flushing by rainwater, thus the residues of explosives should not be considered to prevent the utilization of otherwise mineralogically inert waste rocks of good technical quality. The overall nitrogen management should take into account the background concentrations and sensitivity of the local ecosystem. The research project "Solution for Control of Nitrogen Discharges at Mines and Quarries, (MINIMAN)" was realized during years 2012-2014 as a cooperative

  7. Sensitivity of Nuclide Release Behavior to Groundwater Flow in an HLW Repository

    International Nuclear Information System (INIS)

    Lee, Youn-Myoung; Hwang, Yong-Soo

    2008-01-01

    Evaluation of the dose exposure rate to human being due to long-term nuclide releases from a high-level waste repository (HLW) is of importance to meet the dose limit presented by the regulatory bodies in order to ensure the performance of a repository. During the last few years, tools by which such a dose rate to an individual can be evaluated have been developed and implemented for a practical calculation to demonstrate the suitability of an HLW repository, with the aid of commercial tools such as AMBER and GoldSim, both of which are capable of probabilistic and deterministic calculations with their convenient user interface. Recently a migration from AMBER based models to GoldSim based ones has been made in accordance with a better feature of GoldSim, which is designed to facilitate the object-oriented modules to address any specialized programs, similar to solving jig saw puzzles and shows more advantage in a detailed complex modeling over AMBER. Recently a compartment modeling approach both for a geosphere and biosphere has been mainly carried out with AMBER in KAERI, which causes a necessity for a newly devised system performance evaluation model in which geosphere and biosphere models could be coupled organically together with less conservatism in the frame of the development of a total system performance assessment modeling tool, which could be successfully done with the aid of GoldSim. Therefore, through the current study, some probabilistic results of the GoldSim approach for a normal situation that could take place in a typical HLW repository are introduced

  8. Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity

    Science.gov (United States)

    Shao, Naimin; Su, Yunzhang; Hu, Jingjing; Zhang, Jiahai; Zhang, Hongfeng; Cheng, Yiyun

    2011-01-01

    Background Polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimers are the commercially available and most widely used dendrimers in pharmaceutical sciences and biomedical engineering. In the present study, the loading and release behaviors of generation 3 PAMAM and generation 4 PPI dendrimers with the same amount of surface amine groups (32 per dendrimer) were compared using phenylbutazone as a model drug. Methods The dendrimer-phenylbutazone complexes were characterized by 1H nuclear magnetic resonance and nuclear Overhauser effect techniques, and the cytotoxicity of each dendrimer was evaluated. Results Aqueous solubility results suggest that the generation 3 PAMAM dendrimer has a much higher loading ability towards phenylbutazone in comparison with the generation 4 PPI dendrimer at high phenylbutazone-dendrimer feeding ratios. Drug release was much slower from the generation 3 PAMAM matrix than from the generation 4 PPI dendrimer. In addition, the generation 3 PAMAM dendrimer is at least 50-fold less toxic than generation 4 PPI dendrimer on MCF-7 and A549 cell lines. Conclusion Although the nuclear Overhauser effect nuclear magnetic resonance results reveal that the generation 4 PPI dendrimer with a more hydrophobic interior encapsulates more phenylbutazone, the PPI dendrimer-phenylbutazone inclusion is not stable in aqueous solution, which poses a great challenge during drug development. PMID:22267921

  9. Sorption/Desorption Behavior and Mechanism of NH4(+) by Biochar as a Nitrogen Fertilizer Sustained-Release Material.

    Science.gov (United States)

    Cai, Yanxue; Qi, Hejinyan; Liu, Yujia; He, Xiaowei

    2016-06-22

    Biochar, the pyrolysis product of biomass material with limited oxygen, has the potential to increase crop production and sustained-release fertilizer, but the understanding of the reason for improving soil fertility is insufficient, especially the behavior and mechanism of ammonium sulfate. In this study, the sorption/desorption effect of NH4(+) by biochar deriving from common agricultural wastes under different preparation temperatures from 200 to 500 °C was studied and its mechanism was discussed. The results showed that biochar displayed excellent retention ability in holding NH4(+) above 90% after 21 days under 200 °C preparation temperature, and it can be deduced that the oxygen functional groups, such as carboxyl and keto group, played the primary role in adsorbing NH4(+) due to hydrogen bonding and electrostatic interaction. The sorption/desorption effect and mechanism were studied for providing an optional way to dispose of agricultural residues into biochar as a nitrogen fertilizer sustained-release material under suitable preparation temperature.

  10. Preparation, physicochemical characterization and release behavior of the inclusion complex of trans-anethole and β-cyclodextrin.

    Science.gov (United States)

    Zhang, Wenwen; Li, Xinying; Yu, Taocheng; Yuan, Lun; Rao, Gang; Li, Defu; Mu, Changdao

    2015-08-01

    Trans-anethole (AT) has a variety of antimicrobial properties and is widely used as food functional ingredient. However, the applications of AT are limited due to its low water solubility, strong odor and low physicochemical stability. Therefore, the aim of this work was to encapsulate AT with β-cyclodextrin (β-CD) for obtaining inclusion complex by co-precipitation method. The measurements effectively confirmed the formation of inclusion complex between AT and β-CD. The results showed that the inclusion complex presented new solid crystalline phases and was more thermally stable than the physical mixture and β-CD. The phase solubility study showed that the aqueous solubility of AT was increased by being included in β-CD. The calculated stability constant of inclusion complex was 1195M -1 , indicating the strong interaction between AT and β-CD. Furthermore, the release study suggested that β-CD provided the protection for AT against evaporation. The release behavior of AT from the inclusion complex was controlled. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. The interplay of stressful life events and coping skills on risk for suicidal behavior among youth students in contemporary China: a large scale cross-sectional study

    OpenAIRE

    Tang, Fang; Xue, Fuzhong; Qin, Ping

    2015-01-01

    Background Stressful life events are common among youth students and may induce psychological problems and even suicidal behaviors in those with poor coping skills. This study aims to assess the influence of stressful life events and coping skills on risk for suicidal behavior and to elucidate the underlying mechanism using a large sample of university students in China. Methods 5972 students, randoml...

  12. Behavioral and physiological responses to central administration of corticotropin-releasing factor in the bluebanded goby (Lythrypnus dalli).

    Science.gov (United States)

    Solomon-Lane, Tessa K; Grober, Matthew S

    2012-07-16

    Central manipulation of neuromodulators is critical to establishing causal links between brain function and behavioral output. The absence of a rigorous method of evaluating intracerebroventricular (i.c.v.) injection efficacy in small model organisms is one reason why peripheral administration of neuroactive substances is more common. We use the bluebanded goby (Lythrypnus dalli), a small, highly social fish, to 1) validate our method of i.c.v. injection by testing the hypothesis that corticotropin-releasing factor (CRF) elevates ventilation rate (VR) and 2) propose a novel bioassay using basal physiology and behavior during recovery from anesthesia/i.c.v. administration to assess injection efficacy, neuromodulator activity, and procedural confounds. Central CRF administration significantly increased ventilation rate, demonstrating successful delivery of CRF to the brain. There were no significant differences in cortisol among treatments. The injection procedure did, however, decouple the temporal relationship between the initiation of ventilation and time to regain equilibrium present in control fish. Importantly, neither i.c.v. vehicle nor CRF injection affected the initiation of ventilation, disrupted the stereotyped recovery pattern following anesthesia, or initiated an endocrine stress response. Taken together, we suggest that 1) i.c.v. injection can be effectively used to manipulate central levels of CRF in L. dalli and 2) physiological and behavioral recovery from anesthesia may be used to evaluate injection/technique efficacy. We will use these data in future studies as a measure of effective CRF delivery, to allow for appropriate recovery from i.c.v. injection, and to better evaluate independent effects of CRF on social and/or sexual behavior. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. Impact of physicochemical properties of porous silica materials conjugated with dexamethasone via pH-responsive hydrazone bond on drug loading and release behavior

    Science.gov (United States)

    Numpilai, Thanapha; Witoon, Thongthai; Chareonpanich, Metta; Limtrakul, Jumras

    2017-02-01

    The conjugation of dexamethasone (DEX) onto modified-porous silica materials via a pH-responsive hydrazone bond has been reported to be highly efficient method to specifically deliver the DEX to diseased sites. However, the influence of physicochemical properties of porous silica materials has not yet been fully understood. In this paper, the impact of pore sizes, particle sizes and silanol contents on surface functionalization, drug loading and release behavior of porous silica materials conjugated with dexamethasone via pH-responsive hydrazone bond was investigated. The grafting density was found to relate to the number of silanol groups on the surface of porous silica materials. The particle size and macropores of the porous silica materials played an vital role on the drug loading and release behavior. Although the porous silica materials with larger particle sizes possessed a lower grafting density, a larger amount of drug loading could be achieved. Moreover, the porous silica materials with larger particle sizes showed a slower release rate of DEX due to a longer distance for cleaved DEX diffusion out of pores. DEX release rate exhibited pH-dependent, sustained release. At pH 4.5, the amount of DEX release within 10 days could be controlled in the range of 12.74-36.41%, depending on the host material. Meanwhile, less than 1.5% of DEX was released from each of type of the porous silica materials at pH 7.4. The results of silica dissolution suggested that the degradation of silica matrix did not significantly affect the release rate of DEX. In addition, the kinetic modeling studies revealed that the DEX releases followed Korsmeyer-Peppas model with a release exponent (n) ranged from 0.3 to 0.47, indicating a diffusion-controlled release mechanism.

  14. Analyzing user behavior of the micro-blogging website Sina Weibo during hot social events

    Science.gov (United States)

    Guan, Wanqiu; Gao, Haoyu; Yang, Mingmin; Li, Yuan; Ma, Haixin; Qian, Weining; Cao, Zhigang; Yang, Xiaoguang

    2014-02-01

    The spread and resonance of users’ opinions on Sina Weibo, the most popular micro-blogging website in China, are tremendously influential, having significantly affected the processes of many real-world hot social events. We select 21 hot events that were widely discussed on Sina Weibo in 2011, and do some statistical analyses. Our main findings are that (i) male users are more likely to be involved, (ii) messages that contain pictures and those posted by verified users are more likely to be reposted, while those with URLs are less likely, (iii) the gender factor, for most events, presents no significant difference in reposting likelihood.

  15. A prospective study of the sexual, emotional, and behavioral correlates associated with young women's first and usual coital events.

    Science.gov (United States)

    Tanner, Amanda E; Hensel, Devon J; Fortenberry, J Dennis

    2010-07-01

    First coitus is considered a major transitional event imbued with cultural relevance. Research has focused on classifying women as virgins, with primary interest in pregnancy and sexually transmitted infection prevention and less on sexuality. This study prospectively explored young women's sexual interest and love at first and subsequent coitus. Daily diary data were collected during a longitudinal study of young women's sexual health (N = 387; 14-17 years at enrollment). Variables of interest included sexual interest, love, and contraceptive and disease prevention behaviors. Analysis of variance and multinomial logistic regression were utilized. For first coital events, love and sexual interest were reported about "half of the day," with sexual interest significantly higher on the day of first coitus. Condom use was nine times more likely than no method at first compared to later coital events. For subsequent coitus, feeling of being in love was significantly higher compared to first coitus, with average sexual interest and love significantly higher with use of no contraceptive method over condoms. Condoms were associated with higher feelings of being in love, but lower sexual interest compared to hormonal contraception. The results indicated that sexual interest and love are independent components of coital behavior. Yet the results also suggest that young women's first coitus does not fully capture the expected significance of "losing one's virginity." Thus, at first coitus, women can actively engage in protective behaviors and focus on pleasure. Copyright (c) 2010 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  16. The potential for buoyant displacement gas release events in Tank 241-SY-102 after waste transfer from Tank 241-SY-101

    International Nuclear Information System (INIS)

    Wells, BE; Meyer, P.E.; Chen, G.

    2000-01-01

    Tank 241-SY-101 (SY-101) is a double-shell, radioactive waste storage tank with waste that, before the recent transfer and water back-dilution operations, was capable of retaining gas and producing buoyant displacement (BD) gas release events (GREs). Some BD GREs caused gas concentrations in the tank headspace to exceed the lower flammability limit (LFL). A BD GRE occurs when a portion of the nonconvective layer retains enough gas to become buoyant, rises to the waste surface, breaks up, and releases some of its stored gas. The installation of a mixer pump in 1993 successfully mitigated gas retention in the settled solids layer in SY-101 and has since prevented BD GREs. However, operation of the mixer pump over the years caused gas retention in the floating crust layer and a corresponding accelerated waste level growth. The accelerating crust growth trend observed in 1997--98 led to initiation of sequences of waste removal and water back-dilutions in December 1999. Waste is removed from the mixed slurry layer in Tank SY-101 and transferred into Tank 241-Sy-102 (SY-102). Water is then added back to dissolve soluble solids that retain gas. The initial transfer of 89,500 gallons of SY-101 waste, diluted in-line at 0.94:1 by volume with water, to SY-102 was conducted in December 1999. The second transfer of 230,000 gallons of original SY-101 waste, diluted approximately 0.9:1, was completed in January 2000, and the third transfer of 205,500 gallons of original SY-101 waste diluted at 0.9:1 was completed in March 2000

  17. Is Applied Behavior Analysis Ready for Parapsychology? A Return to Natural Events.

    Science.gov (United States)

    Ruben, Douglas H.; Ruben, Marilyn J.

    1985-01-01

    Argues for the application of behavioral methods including natural observations over reification in parapsychological research. Research methodology stressing the importance of observation, replication, and continuity in applied science is discussed. (Author/BL)

  18. An Affective Events Model of Charismatic Leadership Behavior : A Review, Theoretical Integration, and Research Agenda

    NARCIS (Netherlands)

    Walter, Frank; Bruch, Heike

    2009-01-01

    Although research has long focused on the consequences of leaders' charismatic behavior, the antecedents of such leadership are increasingly gaining scholarly attention. Nevertheless, the antecedent-oriented literature on charismatic leadership has been fragmented to date and lacks theoretical

  19. Brain-behavioral adaptability predicts response to cognitive behavioral therapy for emotional disorders: A person-centered event-related potential study.

    Science.gov (United States)

    Stange, Jonathan P; MacNamara, Annmarie; Kennedy, Amy E; Hajcak, Greg; Phan, K Luan; Klumpp, Heide

    2017-06-23

    Single-trial-level analyses afford the ability to link neural indices of elaborative attention (such as the late positive potential [LPP], an event-related potential) with downstream markers of attentional processing (such as reaction time [RT]). This approach can provide useful information about individual differences in information processing, such as the ability to adapt behavior based on attentional demands ("brain-behavioral adaptability"). Anxiety and depression are associated with maladaptive information processing implicating aberrant cognition-emotion interactions, but whether brain-behavioral adaptability predicts response to psychotherapy is not known. We used a novel person-centered, trial-level analysis approach to link neural indices of stimulus processing to behavioral responses and to predict treatment outcome. Thirty-nine patients with anxiety and/or depression received 12 weeks of cognitive behavioral therapy (CBT). Prior to treatment, patients performed a speeded reaction-time task involving briefly-presented pairs of aversive and neutral pictures while electroencephalography was recorded. Multilevel modeling demonstrated that larger LPPs predicted slower responses on subsequent trials, suggesting that increased attention to the task-irrelevant nature of pictures interfered with reaction time on subsequent trials. Whereas using LPP and RT averages did not distinguish CBT responders from nonresponders, in trial-level analyses individuals who demonstrated greater ability to benefit behaviorally (i.e., faster RT) from smaller LPPs on the previous trial (greater brain-behavioral adaptability) were more likely to respond to treatment and showed greater improvements in depressive symptoms. These results highlight the utility of trial-level analyses to elucidate variability in within-subjects, brain-behavioral attentional coupling in the context of emotion processing, in predicting response to CBT for emotional disorders. Copyright © 2017 Elsevier Ltd

  20. An approach to modeling operator's cognitive behavior using artificial intelligence techniques in emergency operating event sequences

    International Nuclear Information System (INIS)

    Cheon, Se Woo; Sur, Sang Moon; Lee, Yong Hee; Park, Young Taeck; Moon, Sang Joon

    1994-01-01

    Computer modeling of an operator's cognitive behavior is a promising approach for the purpose of human factors study and man-machine systems assessment. In this paper, the states of the art in modeling operator behavior and the current status in developing an operator's model (MINERVA - NPP) are presented. The model is constructed as a knowledge-based system of a blackboard framework and is simulated based on emergency operating procedures

  1. Negative relationship behavior is more important than positive: Correlates of outcomes during stressful life events.

    Science.gov (United States)

    Rivers, Alannah Shelby; Sanford, Keith

    2018-04-01

    When people who are married or cohabiting face stressful life situations, their ability to cope may be associated with two separate dimensions of interpersonal behavior: positive and negative. These behaviors can be assessed with the Couple Resilience Inventory (CRI). It was expected that scales on this instrument would correlate with outcome variables regarding life well-being, stress, and relationship satisfaction. It was also expected that effects for negative behavior would be larger than effects for positive and that the effects might be curvilinear. Study 1 included 325 married or cohabiting people currently experiencing nonmedical major life stressors and Study 2 included 154 married or cohabiting people with current, serious medical conditions. All participants completed an online questionnaire including the CRI along with an alternate measure of couple behavior (to confirm scale validity), a measure of general coping style (to serve as a covariate), and measures of outcome variables regarding well-being, quality of life, perceived stress, and relationship satisfaction. The effects for negative behavior were larger than effects for positive in predicting most outcomes, and many effects were curvilinear. Notably, results remained significant after controlling for general coping style, and scales measuring positive and negative behavior demonstrated comparable levels of validity. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  2. Influence of charge on encapsulation and release behavior of small molecules in self-assembled layer-by-layer microcapsules.

    Science.gov (United States)

    Mandapalli, Praveen K; Labala, Suman; Vanamala, Deekshith; Koranglekar, Manali P; Sakimalla, Lakshmi A; Venuganti, Venkata Vamsi K

    2014-12-01

    The objective of this study is to investigate the influence of charge of model small molecules on their encapsulation and release behavior in layer-by-layer microcapsules (LbL-MC). Poly(styrene sulfonate) and poly(ethylene imine) were sequentially adsorbed on calcium carbonate sacrificial templates to prepare LbL-MC. Model molecules with varying charge, anionic - ascorbic acid, cationic - imatinib mesylate (IM) and neutral - 5-fluorouracil were encapsulated in LbL-MC. Free and encapsulated LbL-MC were characterized using zetasizer, FTIR spectroscope and differential scanning calorimeter. The influence of IM-loaded LbL-MC on cell viability was studied in B16F10 murine melanoma cells. Furthermore, biodistribution of IM-loaded LbL-MC with and without PEGylation was studied in BALB/c mice. Results showed spherical LbL-MC of 3.0 ± 0.4 μm diameter. Encapsulation efficiency of LbL-MC increased linearly (R(2 )= 0.89-0.99) with the increase in solute concentration. Increase in pH from 2 to 6 increased the encapsulation of charged molecules in LbL-MC. Charged molecules showed greater encapsulation efficiency in LbL-MC compared with neutral molecule. In vitro release kinetics showed Fickian and non-Fickian diffusion of small molecules, depending on the nature of molecular interactions with LbL-MC. At 50 μM concentration, free IM showed significantly (p < 0.05) more cytotoxicity compared with IM-loaded LbL-MC. Biodistribution studies showed that PEGylation of LbL-MC decreased the liver and spleen uptake of IM-encapsulated LbL-MC. In conclusion, LbL-MC can be developed as a potential carrier for small molecules depending on their physical and chemical properties.

  3. The effects of cortisol administration on approach-avoidance behavior: An event-related potential study

    NARCIS (Netherlands)

    Peer, J.M. van; Roelofs, K.; Rotteveel, M.; Dijk, J.G. van; Spinhoven, P.; Ridderinkhof, K.R.

    2007-01-01

    We investigated the effects of cortisol administration (50 mg) on approach and avoidance tendencies in low and high trait avoidant healthy young men. Event-related brain potentials (ERPs) were measured during a reaction time task, in which participants evaluated the emotional expression of

  4. Evaluation of a Sustainable Green Living Expo Event: Attendees' Reports of Satisfaction, Learning, and Behavior Change

    Science.gov (United States)

    Diehl, David C.; Swenson, Shelley E.; Wente, Jessica N.

    2012-01-01

    This article presents the evaluation of the Sustainable Big Bend Green Living Expo and Education Fair, which targets participants with a variety of learning opportunities. Evaluation was carried out using onsite surveys along with follow-up surveys and phone interviews. Results indicate that a 1-day sustainability event is a meaningful way to…

  5. Safety analyses for transient behavior of plasma and in-vessel components during plasma abnormal events in fusion reactor

    International Nuclear Information System (INIS)

    Honda, Takuro; Okazaki, Takashi; Bartels, H.W.; Uckan, N.A.; Seki, Yasushi.

    1997-01-01

    Safety analyses on plasma abnormal events have been performed using a hybrid code of a plasma dynamics model and a heat transfer model of in-vessel components. Several abnormal events, e.g., increase in fueling rate, were selected for the International Thermonuclear Experimental Reactor (ITER) and transient behavior of the plasma and the invessel components during the events was analyzed. The physics model for safety analysis was conservatively prepared. In most cases, the plasma is terminated by a disruption or it returns to the original operation point. When the energy confinement improves by a factor of 2.0 in the steady state, which is a hypothetical assumption under the present plasma data, the maximum fusion power reaches about 3.3 GW at about 3.6 s and the plasma is terminated due to a disruption. However, the results obtained in this study show the confinement boundary of ITER can be kept almost intact during the abnormal plasma transients, as long as the cooling system works normally. Several parametric studies are needed to comprehend the overpower transient including structure behavior, since many uncertainties are connected to the filed of the plasma physics. And, future work will need to discuss the burn control scenario considering confinement mode transition, system specifications, experimental plans and safety regulations, etc. to confirm the safety related to the plasma anomaly. (author)

  6. Divorce and Child Behavior Problems: Applying Latent Change Score Models to Life Event Data

    Science.gov (United States)

    Malone, Patrick S.; Lansford, Jennifer E.; Castellino, Domini R.; Berlin, Lisa J.; Dodge, Kenneth A.; Bates, John E.; Pettit, Gregory S.

    2009-01-01

    Effects of parents' divorce on children's adjustment have been studied extensively. This article applies new advances in trajectory modeling to the problem of disentangling the effects of divorce on children's adjustment from related factors such as the child's age at the time of divorce and the child's gender. Latent change score models were used to examine trajectories of externalizing behavior problems in relation to children's experience of their parents' divorce. Participants included 356 boys and girls whose biological parents were married at kindergarten entry. The children were assessed annually through Grade 9. Mothers reported whether they had divorced or separated in each 12-month period, and teachers reported children's externalizing behavior problems each year. Girls' externalizing behavior problem trajectories were not affected by experiencing their parents' divorce, regardless of the timing of the divorce. In contrast, boys who were in elementary school when their parents divorced showed an increase in externalizing behavior problems in the year of the divorce. This increase persisted in the years following the divorce. Boys who were in middle school when their parents divorced showed an increase in externalizing behavior problems in the year of the divorce followed by a decrease to below baseline levels in the year after the divorce. This decrease persisted in the following years. PMID:20209039

  7. The dissociation between the P3a event-related potential and behavioral distraction.

    Science.gov (United States)

    Wetzel, Nicole; Schröger, Erich; Widmann, Andreas

    2013-09-01

    Unexpected novel sounds can capture our attention and impair performance. Recent behavioral research revealed that only novel sounds that provided target-related (but not task-related) information impaired performance. This poses the question of the automaticity of novelty processing and its expression at the behavioral level. In an auditory-visual oddball paradigm, the informational content of sounds regarding the time and probability of target occurrence was varied. Independent from the informational content, novel, and deviant sounds elicited the P3a, an ERP-component related to novelty processing. In contrast, impaired performance was only observed if target-related information was provided. Results indicate that distractor sounds are automatically evaluated as potentially significant, but that the consequences for behavior depend on further processes such as the processing of the given information. Copyright © 2013 Society for Psychophysiological Research.

  8. Contextual events related to the occurrence of challenging behavior in educational settings

    Directory of Open Access Journals (Sweden)

    Alba CORTINA SERRA

    2017-10-01

    Full Text Available Challenging behaviors (CB displayed by people with intellectual disabilities (ID have a negative effect on their quality of life. The operant theory principles emphasize the relationship between these behaviors and the environment where they take place. This study aimed to identify the contextual variables that are closely related to the occurrence of CB exhibited by children who attend a special school by using an indirect functional assessment instrument; the Contextual Assessment Inventory. Therefore, 17 students have participated in this study where a total of 25 behaviors have been assessed. The results suggested that the social/cultural and the nature of the task or activity categories were more strongly associated with the occurrence of CB. Finally, results are discussed in terms of implications for practitioners. Future researches might address the importance of prevention and universal educational systems.

  9. Fission gas release behavior of MOX fuels under simulated daily-load-follow operation condition. IFA-554/555 test evaluation with FASTGRASS code

    International Nuclear Information System (INIS)

    Ikusawa, Yoshihisa; Ozawa, Takayuki

    2008-03-01

    IFA-554/555 load-follow tests were performed in HALDEN reactor (HBWR) to study the MOX fuel behavior under the daily-load-follow operation condition in the framework of ATR-MOX fuel development in JAEA. IFA-554/555 rig had the instruments of rod inner pressure, fuel center temperature, fuel stack elongation, and cladding elongation. Although the daily-load-follow operation in nuclear power plant is one of the available options for economical improvement, the power change in a short period in this operation causes the change of thermal and mechanical irradiation conditions. In this report, FP gas release behavior of MOX fuel rod was evaluated under the daily-load-follow operation condition with the examination data from IFA-554/555 by using the computation code 'FASTGRASS'. From the computation results of FASTGRASS code which could compute the FP gas release behavior under the transient condition, it could be concluded that FP gas was released due to the relaxation of fuel pellet inner stress and pellet temperature increase, which were caused by the cyclic power change during the daily-load-follow operation. In addition, since the amount of released FP gas decreased during the steady operation after the daily-load-follow, it could be mentioned that the total of FP gas release at the end of life with the daily-load-follow is not so much different from that without the daily-load-follow. (author)

  10. Direct Self-Injurious Behavior (D-SIB and Life Events among Vocational School and High School Students

    Directory of Open Access Journals (Sweden)

    Lili O. Horváth

    2018-05-01

    Full Text Available Although several studies have recently assessed direct self-injurious behavior (D-SIB among adolescents, it is still understudied in adolescents attending vocational schools: an educational setting generally associated with lower socioeconomic status. After extending the “Saving and Empowering Young Lives in Europe” (SEYLE project to a vocational school population, we examined their D-SIB and life event characteristics compared to the high school population. SEYLE’s Hungarian randomly selected high school sample (N = 995 was completed with a randomly selected vocational school sample (N = 140 in Budapest, Hungary. Participants aged 14–17 years completed the SEYLE project’s self-administered questionnaires. D-SIB lifetime prevalence was significantly higher (29.4% in the vocational school group compared to the high school group (17.2% (Χ2(1 = 12.231, p< 0.001. D-SIB was associated with suicidal ideation in the vocational school group. Different life events were more frequent in the high school than in the vocational school group, and associations between D-SIB and life events differed in the vocational school group compared to the high school group. In conclusion, vocational school students are a vulnerable population with a higher prevalence of D-SIB compared to high school students. Life events and their association with D-SIB also differ in vocational school students compared to high school students. Taking all these into account might contribute to prevention/intervention designed for this population.

  11. Multi-event behavior of El Golfo landslide (El Hierro Island, Canary Archipelago)

    Science.gov (United States)

    León, Ricardo; Biain, Ander; Urgeles, Roger; Somoza, Luis; Ferrer, Mercedes; García-Crespo, Jesús; Francisco Mediato, José; Galindo, Inés; Yepes, Jorge; Gimenez-Moreno, Julia

    2017-04-01

    Based on the re-interpretation of a vast onshore-offshore data set, a new morpho-structural characterization of the El Golfo giant landslide in the island of El Hierro (Canary Archipelago, Spain) is presented. Offshore multibeam echosounder data, chirp sub-bottom profiles, multichannel seismic reflection data and onshore information from water wells and galleries have been analyzed to determine the nature of the event. The subaerial headscarp shows a non-continuous arcuate profile formed by two nested semi-circular amphitheaters that extend offshore along a smooth chute, suggesting the occurrence of at least two large retrogressive events. Channels/gullies and escarpments developed along the submarine sector of the scar also indicate smaller-scale events and predominance of sediment bypass. At the base of submerged island, two subunits within the related submarine mass transport deposit (MTD) are identified on multichannel seismic reflection profiles confirming the multi-event nature of the landslide. The MTD, identified as a debris avalanche, has a total estimated volume of 318 km3: 84 km3 and 234 km3, for the lower and upper subunits respectively. Data from wells and galleries show abrasion platforms with beach deposits at sea-level (0 masl) formed after the landslide scar and buried by the El Golfo post-collapse infill lavas, suggesting an age at least older than 23.5-82.5 ka for the landslide. This work has been supported by the projects IGCP-640 S4SLIDE, High resolution seabed mapping EASME/EMFF/2016/005 and CTM2010-09496-E. Keywords: Submarine landslides, volcanic islands, debris avalanche, Canary Islands

  12. Chronic Anabolic Androgenic Steroid Exposure Alters Corticotropin Releasing Factor Expression and Anxiety-Like Behaviors in the Female Mouse

    Science.gov (United States)

    Costine, Beth A; Oberlander, Joseph G; Davis, Matthew C; Penatti, Carlos A A; Porter, Donna M; Leaton, Robert N; Henderson, Leslie P

    2010-01-01

    Summary In the past several decades, the therapeutic use of anabolic androgenic steroids (AAS) has been overshadowed by illicit use of these drugs by elite athletes and a growing number of adolescents to enhance performance and body image. As with adults, AAS use by adolescents is associated with a range of behavioral effects, including increased anxiety and altered responses to stress. It has been suggested that adolescents, especially adolescent females, may be particularly susceptible to the effects of these steroids, but few experiments in animal models have been performed to test this assertion. Here we show that chronic exposure of adolescent female mice to a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and methandrostenolone; 7.5 mg/kg/day for 5 days) significantly enhanced anxiety-like behavior as assessed by the acoustic startle response (ASR), but did not augment the fear-potentiated startle response (FPS) or alter sensorimotor gating as assessed by prepulse inhibition of the acoustic startle response (PPI). AAS treatment also significantly increased the levels of corticotropin releasing factor (CRF) mRNA and somal-associated CRF immunoreactivity in the central amygdala (CeA), as well as neuropil-associated immunoreactivity in the dorsal aspect of the anterolateral division of the bed nucleus of the stria terminalis (dBnST). AAS treatment did not alter CRF receptor 1 or 2 mRNA in either the CeA or the dBnST; CRF immunoreactivity in the ventral BNST, the paraventricular nucleus (PVN) or the median eminence (ME); or peripheral levels of corticosterone. These results suggest that chronic AAS treatment of adolescent female mice may enhance generalized anxiety, but not sensorimotor gating or learned fear, via a mechanism that involves increased CRF-mediated signaling from CeA neurons projecting to the dBnST. PMID:20537804

  13. Behavioral and Event-Related-Potential Correlates of Processing Congruent and Incongruent Self-Relevant Information

    Science.gov (United States)

    Clark, Sheri L.

    2013-01-01

    People want to be viewed by others as they view themselves. Being confronted with self-relevant information that is either congruent or incongruent with one's self-view has been shown to differentially affect subsequent behavior, memory for the information, and evaluation of the source of the information. However, no research has examined…

  14. Event-based Modularization: How Emergent Behavioral Patterns Must Be Modularized?

    NARCIS (Netherlands)

    Malakuti Khah Olun Abadi, Somayeh; Aksit, Mehmet

    Nowadays, detecting emergent behavioral patterns in the environment, representing and manipulating them become the main focus of many software systems such as traffic monitoring systems, runtime verification techniques and self-adaptive systems. In this paper, we discuss the need for dedicated

  15. A behavioral framework for compositionality: linear systems, discrete event systems and hybrid systems

    NARCIS (Netherlands)

    Anak Agung Julius, A.A.J.; van der Schaft, Arjan

    2004-01-01

    In this paper we formulate a general framework based on the behavioral approach to dynamical systems, in which various issues regarding interconnection of systems can be addressed. The main part of the framework is that interconnections or compositions of systems can be modelled with interconnection

  16. Randomized Controlled Trial of Osmotic-Release Methylphenidate with Cognitive-Behavioral Therapy in Adolescents with Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders

    Science.gov (United States)

    Riggs, Paula D.; Winhusen, Theresa; Davies, Robert D.; Leimberger, Jeffrey D.; Mikulich-Gilbertson, Susan; Klein, Constance; Macdonald, Marilyn; Lohman, Michelle; Bailey, Genie L.; Haynes, Louise; Jaffee, William B.; Haminton, Nancy; Hodgkins, Candace; Whitmore, Elizabeth; Trello-Rishel, Kathlene; Tamm, Leanne; Acosta, Michelle C.; Royer-Malvestuto, Charlotte; Subramaniam, Geetha; Fishman, Marc; Holmes, Beverly W.; Kaye, Mary Elyse; Vargo, Mark A.; Woody, George E.; Nunes, Edward V.; Liu, David

    2011-01-01

    Objective: To evaluate the efficacy and safety of osmotic-release methylphenidate (OROS-MPH) compared with placebo for attention-deficit/hyperactivity disorder (ADHD), and the impact on substance treatment outcomes in adolescents concurrently receiving cognitive-behavioral therapy (CBT) for substance use disorders (SUD). Method: This was a…

  17. Behavioral measures of cochlear compression and temporal resolution as predictors of speech masking release in hearing-impaired listeners

    Science.gov (United States)

    Gregan, Melanie J.; Nelson, Peggy B.; Oxenham, Andrew J.

    2013-01-01

    Hearing-impaired (HI) listeners often show less masking release (MR) than normal-hearing listeners when temporal fluctuations are imposed on a steady-state masker, even when accounting for overall audibility differences. This difference may be related to a loss of cochlear compression in HI listeners. Behavioral estimates of compression, using temporal masking curves (TMCs), were compared with MR for band-limited (500–4000 Hz) speech and pure tones in HI listeners and age-matched, noise-masked normal-hearing (NMNH) listeners. Compression and pure-tone MR estimates were made at 500, 1500, and 4000 Hz. The amount of MR was defined as the difference in performance between steady-state and 10-Hz square-wave-gated speech-shaped noise. In addition, temporal resolution was estimated from the slope of the off-frequency TMC. No significant relationship was found between estimated cochlear compression and MR for either speech or pure tones. NMNH listeners had significantly steeper off-frequency temporal masking recovery slopes than did HI listeners, and a small but significant correlation was observed between poorer temporal resolution and reduced MR for speech. The results suggest either that the effects of hearing impairment on MR are not determined primarily by changes in peripheral compression, or that the TMC does not provide a sufficiently reliable measure of cochlear compression. PMID:24116426

  18. Release from prey preservation behavior via prey switch allowed diversification of cuticular hydrocarbon profiles in digger wasps.

    Science.gov (United States)

    Wurdack, Mareike; Polidori, Carlo; Keller, Alexander; Feldhaar, Heike; Schmitt, Thomas

    2017-11-01

    The cuticle of insects is covered by a layer of hydrocarbons (CHC), whose original function is the protection from desiccation and pathogens. However, in most insects CHC profiles are species specific. While this variability among species was largely linked to communication and recognition functions, additional selective forces may shape insect CHC profiles. Here, we show that in Philanthinae digger wasps (Crabronidae) the CHC profile coevolved with a peculiar brood-care strategy. In particular, we found that the behavior to embalm prey stored in the nest with hydrocarbons is adaptive to protect larval food from fungi in those species hunting for Hymenoptera. The prey embalming secretion is identical in composition to the alkene-dominated CHC profile in these species, suggesting that their profile is adaptively conserved for this purpose. In contrast, prey embalming is not required in those species that switched to Coleoptera as prey. Released from this chemical brood-care strategy, Coleoptera-hunting species considerably diversified their CHC profiles. Differential needs to successfully protect prey types used as larval food have thus driven the diversification of CHCs profiles of female Philanthinae wasps. To the best of our knowledge, this is the first evidence of a direct link between selection pressure for food preservation and CHC diversity. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

  19. Efficacy of extended-release divalproex combined with "condensed" dialectical behavior therapy for individuals with borderline personality disorder.

    Science.gov (United States)

    Moen, Richelle; Freitag, Mary; Miller, Michael; Lee, Susanne; Romine, Ann; Song, Sue; Adityanjee, Adit; Schulz, S Charles

    2012-11-01

    Borderline personality disorder (BPD) is a significant psychiatric illness for which medication treatments are still being explored. The goal of this study was to assess divalproex extended release (ER) vs placebo for patients receiving dialectal behavior therapy (DBT). Patients with BPD received 4 weeks of "condensed DBT." Those with Symptom Checklist-90 (SCL-90) scores >150 after this treatment were then randomly and blindly assigned to placebo or divalproex ER for 12 weeks. Repeated measures analysis of variance utilizing last observation carried forward was used to assess the results. Seventeen participants completed the full assessment. Two patients had a significant decrease in SCL-90 in the first 4 weeks, leaving 15 patients for the medication phase of the trial. There were no significant differences between the participants assigned to divalproex ER compared with placebo. However, there was a significant improvement in both groups from baseline to endpoint (P = .001). The response of 2 of 17 participants in the first 4 weeks prior to medication may point to a practice strategy in approaching outpatients with BPD. Although the patients had a decrease in symptoms during the study, there was no advantage observed for divalproex ER and DBT over placebo and DBT.

  20. Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol.

    Science.gov (United States)

    Wagle, Mahendra; Mathur, Priya; Guo, Su

    2011-01-05

    The zebrafish camouflage response is an innate "hard-wired" behavior that offers an excellent opportunity to explore neural circuit assembly and function. Moreover, the camouflage response is sensitive to ethanol, making it a tractable system for understanding how ethanol influences neural circuit development and function. Here we report the identification of corticotropin-releasing factor (CRF) as a critical component of the camouflage response pathway. We further show that ethanol, having no direct effect on the visual sensory system or the melanocytes, acts downstream of retinal ganglion cells and requires the CRF-proopiomelanocortin pathway to exert its effect on camouflage. Treatment with ethanol, as well as alteration of light exposure that changes sensory input into the camouflage circuit, robustly modifies CRF expression in subsets of neurons. Activity of both adenylyl cyclase 5 and extracellular signal-regulated kinase (ERK) is required for such ethanol-induced or light-induced plasticity of crf expression. These results reveal an essential role of a peptidergic pathway in camouflage that is regulated by light and influenced by ethanol at concentrations relevant to abuse and anxiolysis, in a cAMP-dependent and ERK-dependent manner. We conclude that this ethanol-modulated camouflage response represents a novel and relevant system for molecular genetic dissection of a neural circuit that is regulated by light and sensitive to ethanol.

  1. Culture and context: buffering the relationship between stressful life events and risky behaviors in American Indian youth.

    Science.gov (United States)

    Baldwin, Julie A; Brown, Betty G; Wayment, Heidi A; Nez, Ramona Antone; Brelsford, Kathleen M

    2011-01-01

    The Sacred Mountain Youth Project was conducted to investigate risk and protective factors related to alcohol and drug use among American Indian youth. Findings indicated that stressful life events were positively associated with depressed mood, substance use, and risky behavior; cultural identity had no direct effects, but a secondary model showed that social support and protective family and peer influences were related to cultural identity. These findings suggest that the relationships between stressors and their negative sequelae are complex. Emphasis on protective processes that are culturally specific to American Indian youth may lead to effective alcohol and drug use prevention programs.

  2. Chronic moderate alcohol drinking alters insulin release without affecting cognitive and emotion-like behaviors in rats.

    Science.gov (United States)

    Nelson, Nnamdi G; Suhaidi, Faten A; Law, Wen Xuan; Liang, Nu-Chu

    2017-12-16

    of insulin release for proper glucose clearance. Such an effect was not observed in females. This landmark study shows that chronic moderate alcohol consumption can have negative metabolic consequences in the absence of overt behavioral deficits, especially in males. Published by Elsevier Inc.

  3. Study of aerosol behavior on the basis of morphological characteristics during festival events in India

    Science.gov (United States)

    Agrawal, Anubha; Upadhyay, Vinay K.; Sachdeva, Kamna

    2011-07-01

    Two important festival events were selected to assess their impacts on atmospheric chemistry by understanding settling velocity and emission time of aerosols. Using high volume sampler, aerosols were collected in a sequential manner to understand settling velocity and emission time of aerosols on a particular day. Composition and total suspended particulate load of the aerosols collected during the festivals were used as markers for strengthening the assessment. Terminal settling velocity of the aerosols were calculated using morphological and elemental compositional data, obtained from scanning electron microcopy (SEM) and energy dispersive X-ray (EDX) study. Aerosol load, black carbon, aromatic carbon and terminal velocity calculations were correlated to obtain conclusion that aerosols collected on the festival day might have been emitted prior to the festival. Settling time of aerosols collected on 17th and 19th October'09 during Diwali were found to be 36.5 (1.5 days) and 12.8 h, respectively. Carbon concentration estimated using EDX was found to be almost double in the sample collected after 2 days of the festival event. This strengthens our inference of time calculation where carbon with high concentration of load must have settled approximately after two days of the event. Settling time of aerosols collected on Holi morning and afternoon was found to be 1.7 and 24.8 h, respectively. Further, because of the small distance of 5.4 km between the meteorological station and sampling site, observed TSP values were compared with theoretical load values, calculated by using visibility values taken from the meteorological data. And it was found that both experimental and calculated values are close to each other about 50% of the times, which proves the assumption that experimental and meteorological data are comparable.

  4. Experimental Study of Air Vessel Behavior for Energy Storage or System Protection in Water Hammer Events

    Directory of Open Access Journals (Sweden)

    Mohsen Besharat

    2017-01-01

    Full Text Available An experimental assessment of an air pocket (AP, confined in a compressed air vessel (CAV, has been investigated under several different water hammer (WH events to better define the use of protection devices or compressed air energy storage (CAES systems. This research focuses on the size of an AP within an air vessel and tries to describe how it affects important parameters of the system, i.e., the pressure in the pipe, stored pressure, flow velocity, displaced volume of water and water level in the CAV. Results present a specific range of air pockets based on a dimensionless parameter extractable for other real systems.

  5. Dynamical Behavior of a Rumor Transmission Model with Psychological Effect in Emergency Event

    Directory of Open Access Journals (Sweden)

    Liang'an Huo

    2013-01-01

    Full Text Available A rumor transmission model with nonmonotonic incidence rate was proposed, which provides excellent explanations of the “psychological” effect with rumor spreading in emergency event. By carrying out a global analysis of the model and studying the stability of the rumor-free equilibrium and the rumor-endemic equilibrium, we showed that either the number of infective individuals tends to zero as time evolves or the rumor persists. Finally, recommendations for policy makers and consulting advice for related commissions are explored in the case study of crazy rumors propagated for the iodized sail shortage panic in China.

  6. Plasma behavior during energetic electron streaming events: Further evidence for substorm-associated magnetic reconnection

    International Nuclear Information System (INIS)

    Bieber, J.W.; Stone, E.C.; Hones, E.W. Jr.; Baker, D.N.; Bame, S.J.

    1982-01-01

    A recent study showed that streaming energetic (>200 keV) electrons in Earth's magnetotail are statistically associated with southward magnetic fields and with enhancements of the AE index. It is shown here that the streaming electrons characteristically are preceded by aapprox.15 minute period of tailward plasma flow and followed by a dropout of the plasma sheet, thus demonstrating a clear statistical association between substorms and the classical signatures of magnetic reconnection and plasmoid formation. Additionally, a brief upward surge of mean electron energy preceded plasma dropout in several of the events studied, providing direct evidence of localized, reconnection-associated heating processes

  7. Gambling behavior and problem gambling reflecting social transition and traumatic childhood events among Greenland Inuit

    DEFF Research Database (Denmark)

    Larsen, Christina Viskum Lytken; Curtis, Tine; Bjerregaard, Peter

    Aims: An increase in social pathologies is a key feature in indigenous populations undergoing transition. The Greenland Inuit are a large indigenous population constituting a majority in their own country, which makes it possible to investigate differences within the population. This led us to st...... of social pathologies in Greenland. A significant association between lifetime problem gambling, social transition and traumatic childhood events suggests people caught between tradition and modern ways of life are more vulnerable to gambling problems....... was measured as place of residence and a combination of residence, education and occupation. Findings: The lifetime prevalence of problem gambling was 16% among men and 10% among women (p

  8. Early Results of Three-Year Monitoring of Red Wood Ants’ Behavioral Changes and Their Possible Correlation with Earthquake Events

    Directory of Open Access Journals (Sweden)

    Gabriele Berberich

    2013-02-01

    Full Text Available Short-term earthquake predictions with an advance warning of several hours or days are currently not possible due to both incomplete understanding of the complex tectonic processes and inadequate observations. Abnormal animal behaviors before earthquakes have been reported previously, but create problems in monitoring and reliability. The situation is different with red wood ants (RWA; Formica rufa-group (Hymenoptera: Formicidae. They have stationary mounds on tectonically active, gas-bearing fault systems. These faults may be potential earthquake areas. For three years (2009–2012, two red wood ant mounds (Formica rufa-group, located at the seismically active Neuwied Basin (Eifel, Germany, have been monitored 24/7 by high-resolution cameras with both a color and an infrared sensor. Early results show that ants have a well-identifiable standard daily routine. Correlation with local seismic events suggests changes in the ants’ behavior hours before the earthquake: the nocturnal rest phase and daily activity are suppressed, and standard daily routine does not resume until the next day. At present, an automated image evaluation routine is being applied to the more than 45,000 hours of video streams. Based on this automated approach, a statistical analysis of the ants’ behavior will be carried out. In addition, other parameters (climate, geotectonic and biological, which may influence behavior, will be included in the analysis.

  9. Adverse Life Events and Psychopathology and Prosocial Behavior in Late Adolescence: Testing the Timing, Specificity, Accumulation, Gradient, and Moderation of Contextual Risk

    Science.gov (United States)

    Flouri, Eirini; Kallis, Constantinos

    2007-01-01

    A study examines the role of contextual risk in psychopathology and prosocial behavior in adolescents. The results show that risk accumulation matters instead of specificity and that the number of adverse life events is nonmultiplicative with psychopathology.

  10. Early Results of Three-Year Monitoring of Red Wood Ants’ Behavioral Changes and Their Possible Correlation with Earthquake Events

    Science.gov (United States)

    Berberich, Gabriele; Berberich, Martin; Grumpe, Arne; Wöhler, Christian; Schreiber, Ulrich

    2013-01-01

    Simple Summary For three years (2009–2012), two red wood ant mounds (Formica rufa-group), located at the seismically active Neuwied Basin (Eifel, Germany), have been monitored 24/7 by high-resolution cameras. Early results show that ants have a well-identifiable standard daily routine. Correlation with local seismic events suggests changes in the ants’ behavior hours before the earthquake: the nocturnal rest phase and daily activity are suppressed, and standard daily routine does not resume until the next day. At present, an automated image evaluation routine is being applied to the video streams. Based on this automated approach, a statistical analysis of the ant behavior will be carried out. Abstract Short-term earthquake predictions with an advance warning of several hours or days are currently not possible due to both incomplete understanding of the complex tectonic processes and inadequate observations. Abnormal animal behaviors before earthquakes have been reported previously, but create problems in monitoring and reliability. The situation is different with red wood ants (RWA; Formica rufa-group (Hymenoptera: Formicidae)). They have stationary mounds on tectonically active, gas-bearing fault systems. These faults may be potential earthquake areas. For three years (2009–2012), two red wood ant mounds (Formica rufa-group), located at the seismically active Neuwied Basin (Eifel, Germany), have been monitored 24/7 by high-resolution cameras with both a color and an infrared sensor. Early results show that ants have a well-identifiable standard daily routine. Correlation with local seismic events suggests changes in the ants’ behavior hours before the earthquake: the nocturnal rest phase and daily activity are suppressed, and standard daily routine does not resume until the next day. At present, an automated image evaluation routine is being applied to the more than 45,000 hours of video streams. Based on this automated approach, a statistical analysis of

  11. Behavioral activation for dementia caregivers: scheduling pleasant events and enhancing communications

    OpenAIRE

    Au, Alma; Gallagher-Thompson, Dolores; Wong, Meng-Kong; Leung, Jess; Chan, Wai-Chi; Chan, Chun Chung; Lu, Hui-Jing; Lai, Man Kin; Chan, Kevin

    2015-01-01

    Alma Au,1,2 Dolores Gallagher-Thompson,3 Meng-Kong Wong,4 Jess Leung,4 Wai-Chi Chan,5 Chun Chung Chan,6 Hui-Jing Lu,1 Man Kin Lai,1 Kevin Chan11Department of Applied Social Sciences, 2Institute of Active Aging, The Hong Kong Polytechnic University, Hong Kong, People’s Republic of China; 3Department of Psychiatry and Behavioral Sciences and Geriatric Education Centre, School of Medicine, Stanford University, Stanford, CA, USA; 4Department of Psychiatry, United Christian Hosp...

  12. Morphology of Gas Release in Physical Simulants

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, Richard C.; Burns, Carolyn A.; Crawford, Amanda D.; Hylden, Laura R.; Bryan, Samuel A.; MacFarlan, Paul J.; Gauglitz, Phillip A.

    2014-07-03

    This report documents testing activities conducted as part of the Deep Sludge Gas Release Event Project (DSGREP). The testing described in this report focused on evaluating the potential retention and release mechanisms of hydrogen bubbles in underground radioactive waste storage tanks at Hanford. The goal of the testing was to evaluate the rate, extent, and morphology of gas release events in simulant materials. Previous, undocumented scoping tests have evidenced dramatically different gas release behavior from simulants with similar physical properties. Specifically, previous gas release tests have evaluated the extent of release of 30 Pa kaolin and 30 Pa bentonite clay slurries. While both materials are clays and both have equivalent material shear strength using a shear vane, it was found that upon stirring, gas was released immediately and completely from bentonite clay slurry while little if any gas was released from the kaolin slurry. The motivation for the current work is to replicate these tests in a controlled quality test environment and to evaluate the release behavior for another simulant used in DSGREP testing. Three simulant materials were evaluated: 1) a 30 Pa kaolin clay slurry, 2) a 30 Pa bentonite clay slurry, and 3) Rayleigh-Taylor (RT) Simulant (a simulant designed to support DSGREP RT instability testing. Entrained gas was generated in these simulant materials using two methods: 1) application of vacuum over about a 1-minute period to nucleate dissolved gas within the simulant and 2) addition of hydrogen peroxide to generate gas by peroxide decomposition in the simulants over about a 16-hour period. Bubble release was effected by vibrating the test material using an external vibrating table. When testing with hydrogen peroxide, gas release was also accomplished by stirring of the simulant.

  13. The interplay of stressful life events and coping skills on risk for suicidal behavior among youth students in contemporary China: a large scale cross-sectional study.

    Science.gov (United States)

    Tang, Fang; Xue, Fuzhong; Qin, Ping

    2015-07-31

    Stressful life events are common among youth students and may induce psychological problems and even suicidal behaviors in those with poor coping skills. This study aims to assess the influence of stressful life events and coping skills on risk for suicidal behavior and to elucidate the underlying mechanism using a large sample of university students in China. 5972 students, randomly selected from 6 universities, completed the questionnaire survey. Logistic regression analysis was performed to estimate the effect of stressful life events and coping skills on risk for suicidal behavior. Bayesian network was further adopted to probe their probabilistic relationships. Of the 5972 students, 7.64% reported the presence of suicidal behavior (attempt or ideation) within the past one year period. Stressful life events such as strong conflicts with classmates and a failure in study exam constituted strong risk factors for suicidal behavior. The influence of coping skills varied according to the strategies adapted toward problems with a high score of approach coping skills significantly associated with a reduced risk of suicidal behavior. The Bayesian network indicated that the probability of suicidal behavior associated with specific life events was to a large extent conditional on coping skills. For instance, a stressful experience of having strong conflicts with classmates could result in a probability of suicidal behavior of 21.25% and 15.36% respectively, for female and male students with the score of approach coping skills under the average. Stressful life events and deficient coping skills are strong risk factors for suicidal behavior among youth students. The results underscore the importance of prevention efforts to improve coping skills towards stressful life events.

  14. Thermal behavior of molten corium during TMI-2 core relocation event

    International Nuclear Information System (INIS)

    Anderson, J.L.; Sienicki, J.J.

    1988-01-01

    During the TMI-2 accident, a pool of molten corium formed in the central region of the core and was contained by solidified crusts. Failure of the crust surrounding the molten material, at approximately 224 min, resulted in a relocation of an estimated 20-25 tons of molten corium through peripheral fuel assemblies in the east side of the vessel, as well as through the core barrel assembly (CBA) at the periphery of the core. This paper presents the results of an analyses carried out to investigate the thermal interactions of molten corium with the CBA structures during the relocation event. The principal objectives of the analyses are: (a) to assess the potential for relocation to take place through the CBA versus the flow of molten core material directly downward through the core via the fuel assemblies; and (b) to understand the distribution of prior molten corium observed during vessel defueling examinations. 5 refs., 1 fig

  15. Thermosensitive mPEG-b-PA-g-PNIPAM comb block copolymer micelles: effect of hydrophilic chain length and camptothecin release behavior.

    Science.gov (United States)

    Yang, Xiao-Li; Luo, Yan-Ling; Xu, Feng; Chen, Ya-Shao

    2014-02-01

    Block copolymer micelles are extensively used as drug controlled release carriers, showing promising application prospects. The comb or brush copolymers are especially of great interest, whose densely-grafted side chains may be important for tuning the physicochemical properties and conformation in selective solvents, even in vitro drug release. The purpose of this work was to synthesize novel block copolymer combs via atom transfer radical polymerization, to evaluate its physicochemical features in solution, to improve drug release behavior and to enhance the bioavailablity, and to decrease cytotoxicity. The physicochemical properties of the copolymer micelles were examined by modulating the composition and the molecular weights of the building blocks. A dialysis method was used to load hydrophobic camptothecin (CPT), and the CPT release and stability were detected by UV-vis spectroscopy and high-performance liquid chromatography, and the cytotoxicity was evaluated by MTT assays. The copolymers could self-assemble into well-defined spherical core-shell micelle aggregates in aqueous solution, and showed thermo-induced micellization behavior, and the critical micelle concentration was 2.96-27.64 mg L(-1). The micelles were narrow-size-distribution, with hydrodynamic diameters about 128-193 nm, depending on the chain length of methoxy polyethylene glycol (mPEG) blocks and poly(N-isopropylacrylamide) (PNIPAM) graft chains or/and compositional ratios of mPEG to PNIPAM. The copolymer micelles could stably and effectively load CPT but avoid toxicity and side-effects, and exhibited thermo-dependent controlled and targeted drug release behavior. The copolymer micelles were safe, stable and effective, and could potentially be employed as CPT controlled release carriers.

  16. Busy period analysis, rare events and transient behavior in fluid flow models

    Directory of Open Access Journals (Sweden)

    Søren Asmussen

    1994-01-01

    Full Text Available We consider a process {(Jt,Vt}t≥0 on E×[0,∞, such that {Jt} is a Markov process with finite state space E, and {Vt} has a linear drift ri on intervals where Jt=i and reflection at 0. Such a process arises as a fluid flow model of current interest in telecommunications engineering for the purpose of modeling ATM technology. We compute the mean of the busy period and related first passage times, show that the probability of buffer overflow within a busy cycle is approximately exponential, and give conditioned limit theorems for the busy cycle with implications for quick simulation. Further, various inequalities and approximations for transient behavior are given. Also explicit expressions for the Laplace transform of the busy period are found. Mathematically, the key tool is first passage probabilities and exponential change of measure for Markov additive processes.

  17. Dome growth behavior at Soufriere Hills Volcano, Montserrat, revealed by relocation of volcanic event swarms, 1995-1996

    Science.gov (United States)

    Rowe, C.A.; Thurber, C.H.; White, R.A.

    2004-01-01

    We have relocated a subset of events from the digital waveform catalogue of ???17,000 volcanic microearthquakes recorded between July 1995 and February 1996 at Soufriere Hills Volcano (SHV), Montserrat, using a cross-correlation-based phase repicking technique with a joint location method. Hypocenters were estimated for 3914 earthquakes having five or more corrected P-wave picks. The seismic source region collapsed to a volume of ???1 km3 from an initial ???100 km3. Relocated events represent 36 swarms, each containing nearly identical waveforms, having source dimensions of 10 to 100 m in diameter and spatial separations on the order of 500 m or less. Each swarm occurred over a span of several hours to a few days.Triggered data appear to miss between 65% and 98% of the events that occur within these swarms, based on review of helicorder records. Visual estimates of summit dome growth show a rough correspondence between episodes of intense swarming and increases in extruded magma, although dome observations are too sparse to make a direct comparison for this time period. The limited depth range over which dome-growth-related events occur is consistent with a dynamic model of cyclic plug extrusion behavior in the shallow conduit, governed by magma supply rate, overpressure buildup and physical properties of the magma and conduit geometry. Seismic sources may occur in locally overpressured regions that result from microlite formation in a zone of rapid decompression; we propose that this zone exists in the vicinity of a detachment plane associated with the cyclic plug extrusion. ?? 2004 Elsevier B.V. All rights reserved.

  18. The development of involuntary and voluntary attention from childhood to adulthood: a combined behavioral and event-related potential study.

    Science.gov (United States)

    Wetzel, Nicole; Widmann, Andreas; Berti, Stefan; Schröger, Erich

    2006-10-01

    This study investigated auditory involuntary and voluntary attention in children aged 6-8, 10-12 and young adults. The strength of distracting stimuli (20% and 5% pitch changes) and the amount of allocation of attention were varied. In an auditory distraction paradigm event-related potentials (ERPs) and behavioral data were measured from subjects either performing a sound duration discrimination task or watching a silent video. Pitch changed sounds caused prolonged reaction times and decreased hit rates in all age groups. Larger distractors (20%) caused stronger distraction in children, but not in adults. The amplitudes of mismatch negativity (MMN), P3a, and reorienting negativity (RON) were modulated by age and by voluntary attention. P3a was additionally affected by distractor strength. Maturational changes were also observed in the amplitudes of P1 (decreasing with age) and N1 (increasing with age). P2-modulation by voluntary attention was opposite in young children and adults. Results suggest quantitative and qualitative changes in auditory voluntary and involuntary attention and distraction during development. The processing steps involved in distraction (pre-attentive change detection, attention switch, reorienting) are functional in children aged 6-8 but reveal characteristic differences to those of young adults. In general, distractibility as indicated by behavioral and ERP measures decreases from childhood to adulthood. Behavioral and ERP markers for different processing stages involved in voluntary and involuntary attention reveal characteristic developmental changes from childhood to young adulthood.

  19. Acute nicotine fails to alter event-related potential or behavioral performance indices of auditory distraction in cigarette smokers.

    Science.gov (United States)

    Knott, Verner J; Scherling, Carole S; Blais, Crystal M; Camarda, Jordan; Fisher, Derek J; Millar, Anne; McIntosh, Judy F

    2006-04-01

    Behavioral studies have shown that nicotine enhances performance in sustained attention tasks, but they have not shown convincing support for the effects of nicotine on tasks requiring selective attention or attentional control under conditions of distraction. We investigated distractibility in 14 smokers (7 females) with event-related brain potentials (ERPs) and behavioral performance measures extracted from an auditory discrimination task requiring a choice reaction time response to short- and long-duration tones, both with and without embedded deviants. Nicotine gum (4 mg), administered in a randomized, double-blind, placebo-controlled crossover design, failed to counter deviant-elicited behavioral distraction (i.e., slower reaction times and increased response errors), and it did not influence the distracter-elicited mismatch negativity, the P300a, or the reorienting negativity ERP components reflecting acoustic change detection, involuntary attentional switching, and attentional reorienting, respectively. Results are discussed in relation to a stimulus-filter model of smoking and in relation to future research directions.

  20. The impact of being involved in a medical adverse event on GP's (General Physicians) professional behavior in an ambulatory healthcare fund

    NARCIS (Netherlands)

    Manor, Orly

    2017-01-01

    Assurance behavior: performing unnecessary tests so as to deter patients from filing complaints or medical malpractice suits Avoidance behavior: choosing to behave in a way that prevents recurrence of an unpleasant stimulus This thesis examines the impact of involvement in a medical adverse event on

  1. Estimation of the environmental or radiological impact in the event of accidental release of radionuclides in a DCLL fusion reactor; Estimacion del impacto radiologico ambiental en caso de liberacion accidental de radionucleidos en un reactor de fusion DCLL

    Energy Technology Data Exchange (ETDEWEB)

    Palermo, I.; Gomez Ros, J. M.; Sanz, J.; Mota, F.

    2013-07-01

    Tritium production and activation in the LiPb products can pose a radiological risk in the event of accidental release in a fusion reactor. Within the research programme Consolider TECNO{sub F}US (CSD2008-079) fusion technology has developed a design for a reactor with regenerative wrap with dual refrigeration (DCLL). The purpose of this communication is to present estimates of the radiological impact derived from an accidental release of radionuclides from the circuit of LiPb provinients. (Author)

  2. Disentangling the Attention Network Test: Behavioral, Event Related Potentials and neural source analyses.

    Directory of Open Access Journals (Sweden)

    Alejandro eGalvao-Carmona

    2014-10-01

    Full Text Available Background. The study of the attentional system remains a challenge for current neuroscience. The Attention Network Test (ANT was designed to study simultaneously three different attentional networks (alerting, orienting and executive based in subtraction of different experimental conditions. However, some studies recommend caution with these calculations due to the interactions between the attentional networks. In particular, it is highly relevant that several interpretations about attentional impairment have arisen from these calculations in diverse pathologies. Event Related Potentials (ERPs and neural source analysis can be applied to disentangle the relationships between these attentional networks not specifically shown by behavioural measures. Results. This study shows that there is a basic level of alerting (tonic alerting in the no cue condition, represented by a slow negative trend in the ERP trace prior to the onset of the target stimuli. A progressive increase in the CNV amplitude related to the amount of information provided by the cue conditions is also shown. Neural source analysis reveals specific modulations of the CNV related to a task-related expectancy presented in the no cue condition; a late modulation triggered by the central cue condition and probably representing a generic motor preparation; and an early and late modulation for spatial cue condition suggesting specific motor and sensory preactivation. Finally, the first component in the information processing of the target stimuli modulated by the interaction between orienting network and the executive system can be represented by N1. Conclusions. The ANT is useful as a paradigm to study specific attentional mechanisms and their interactions. However, calculation of network effects is based in subtractions with non-comparable experimental conditions, as evidenced by the present data, which can induce misinterpretations in the study of the attentional capacity in human

  3. Sexually transmitted infections, sexual risk behavior, and intimate partner violence among African American adolescent females with a male sex partner recently released from incarceration.

    Science.gov (United States)

    Swartzendruber, Andrea; Brown, Jennifer L; Sales, Jessica M; Murray, Colleen C; DiClemente, Ralph J

    2012-08-01

    Social networks directly and indirectly influence sexually transmitted infections (STIs) risk. The objective was to explore associations between sex with a male recently released from incarceration and sexual risk and intimate partner violence (IPV) among African American adolescent females. Sociodemographic, psychosocial, and sexual behavior data were collected at baseline, 6, and 12 months from African American females, aged 15-21 years, participating in an HIV/STI prevention trial. Among 653 participants with ≥1 follow-up assessments, generalized estimating equations tested associations during follow-up between having a recently released partner and STI acquisition, sexual risk behaviors, and IPV, adjusting for age, treatment assignment, and corresponding baseline measure. Eighty-three (13.6%) participants had a recently released partner at 6 months and 56 (9.3%) at 12 months. Participants with a recently released partner were more likely to have the following: vaginal (adjusted odds ratio [AOR]: 5.48), anal (AOR: 2.43), and oral (AOR: 1.51) sex, a casual partner (AOR: 1.66), sex while high/drunk (AOR: 1.57) or with a high/drunk partner (AOR: 2.27); use condoms inconsistently (AOR: .58); acquire Chlamydia (AOR: 1.80), and experience emotional (AOR: 4.09), physical (AOR: 2.59), or sexual abuse (AOR: 4.10) by a boyfriend. They had a greater number of sex partners, lower partner communication and refusal self-efficacy, were high/drunk during sex more frequently, and used condoms during oral sex less frequently. A recently released sex partner is associated with sexual risk and IPV among African American adolescent females. Prevention programs should inform adolescents about potential risks associated with recently released partners as well as provide adolescents with skills to establish and maintain healthy sexual relationships. Copyright © 2012 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  4. Eslicarbazepine acetate as a replacement for levetiracetam in people with epilepsy developing behavioral adverse events.

    Science.gov (United States)

    Jalihal, Virupakshi; Shankar, Rohit; Henley, William; Parrett, Mary; Tittensor, Phil; McLean, Brendan N; Ahmed, Ammad; Sander, Josemir W

    2018-03-01

    Psychiatric and behavioral side effects (PBSEs) are a major cause of antiepileptic drug (AED) withdrawal. Levetiracetam (LEV) is a recognized first-line AED with good seizure outcomes but recognized with PBSEs. Eslicarbazepine (ESL) is considered to function similarly to an active metabolite of the commonly used carbamazepine (CBZ). Carbamazepine is used as psychotropic medication to assist in various psychiatric illnesses such as mood disorders, aggression, and anxiety. The aim was to evaluate the psychiatric profile of ESL in people who had LEV withdrawn due to PBSEs in routine clinical practice to see if ESL can be used as a possible alternative to LEV. A retrospective observational review was conducted in two UK epilepsy centers looking at all cases exposed to ESL since its licensing in 2010. The ESL group was all patients with treatment-resistant epilepsy who developed intolerable PBSEs to LEV, subsequently trialed on ESL. The ESL group was matched to a group who tolerated LEV without intolerable PBSEs. Psychiatric disorders were identified from case notes. The Hamilton Depression Scale (HAM-D) was used to outcome change in mood. Clinical diagnoses of a mental disorder were compared between groups using the Fisher's exact test. Group differences in HAM-D scores were assessed using the independent samples t-test (alpha=0.05). The total number of people with active epilepsy in the two centers was 2142 of whom 46 had been exposed to ESL. Twenty-six had previous exposure to LEV and had intolerable PBSEs who were matched to a person tolerating LEV. There was no statistical differences in the two groups for mental disorders including mood as measured by HAM-D (Chi-square test: p=0.28). The ESL was well tolerated and did not produce significant PBSEs in those who had PBSEs with LEV leading to withdrawal of the drug. Though numbers were small, the findings suggest that ESL could be a treatment option in those who develop PBSEs with LEV and possibly other AEDs

  5. Modeling of fuel performance and fission product release behavior during HTTR normal operation. A comparative study of the FZJ and JAERI modeling approach

    International Nuclear Information System (INIS)

    Verfondern, Karl; Sumita, Junya; Ueta, Shohei; Sawa, Kazuhiro

    2001-03-01

    For the prediction of fuel performance and fission product release behavior in the High Temperature Engineering Test Reactor, HTTR of the Japan Atomic Energy Research Institute(JAERI), during its normal operation, calculation tools were applied as have been used at the Research Center Juelich (FZJ) in safety analyses for pebble-bed HTGR designs. Calculations were made assuming the HTTR operation with a nominal operation time of 660 efpd including a 110 efpd period with elevated fuel temperatures. Fuel performance calculations by the PANAMA code with given fuel temperature distribution in the core have shown that the additional failure level of about 5x10 -6 is expected which is about twice as much as the as-fabricated through-coatings failure level. Under the extreme safety design conditions, the predicted particle failure fraction in the core increases to about 1x10 -3 in maximum. The diffusive release of metallic fission products from the fuel primarily occurs in the core layer with the maximum fuel temperature (layer 3) whereas there is hardly any contribution from layer 1 except for the recoil fraction. Silver most easily escapes the fuel; the predicted release fractions from the fuel compacts are 10% (expected) and 50% (safety design). The figures for strontium (expected: 1.5x10 -3 ), safety design: 3.1x10 -2 ) and cesium (5.6x10 -4 , 2.9x10 -2 ) reveal as well a significant fraction to originate already from intact particles. Comparison with the calculation based on JAERI's diffusion model for cesium shows a good agreement for the release behavior from the particles. The differences in the results can be explained mainly by the different diffusion coefficients applied. The release into the coolant can not modelled because of the influence of the gap between compact and graphite sleeve lowering the release by a factor of 3 to 10. For the prediction of performance and fission product release behavior of advanced ZrC TRISO particles, more experimental work is

  6. Adverse life events and delinquent behavior among Kenyan adolescents: a cross-sectional study on the protective role of parental monitoring, religiosity, and self-esteem.

    Science.gov (United States)

    Kabiru, Caroline W; Elung'ata, Patricia; Mojola, Sanyu A; Beguy, Donatien

    2014-01-01

    Past research provides strong evidence that adverse life events heighten the risk of delinquent behavior among adolescents. Urban informal (slum) settlements in sub-Saharan Africa are marked by extreme adversity. However, the prevalence and consequences of adverse life events as well as protective factors that can mitigate the effects of exposure to these events in slum settlements is largely understudied. We examine two research questions. First, are adverse life events experienced at the individual and household level associated with a higher likelihood of delinquent behavior among adolescents living in two slums in Nairobi, Kenya? Second, are parental monitoring, religiosity, and self-esteem protective against delinquency in a context of high adversity? We used cross-sectional data from 3,064 males and females aged 12-19 years who participated in the Transitions to Adulthood Study. We examined the extent to which a composite index of adverse life events was associated with delinquent behavior (measured using a composite index derived from nine items). We also examined the direct and moderating effects of three protective factors: parental monitoring, religiosity, and self-esteem. Fifty-four percent of adolescents reported at least one adverse life event, while 18% reported three or more adverse events. For both males and females, adversity was positively and significantly associated with delinquency in bivariate and multivariate models. Negative associations were observed between the protective factors and delinquency. Significant adverse events × protective factor interaction terms were observed for parental monitoring (females and males), religiosity (males), and self-esteem (females). Similar to research in high income countries, adverse life events are associated with an increased likelihood of delinquent behavior among adolescents living in urban slums in Kenya, a low-income country. However, parental monitoring, religiosity, and self-esteem may

  7. Behavioral impact of unisensory and multisensory audio-tactile events: pros and cons for interlimb coordination in juggling.

    Directory of Open Access Journals (Sweden)

    Gregory Zelic

    Full Text Available Recent behavioral neuroscience research revealed that elementary reactive behavior can be improved in the case of cross-modal sensory interactions thanks to underlying multisensory integration mechanisms. Can this benefit be generalized to an ongoing coordination of movements under severe physical constraints? We choose a juggling task to examine this question. A central issue well-known in juggling lies in establishing and maintaining a specific temporal coordination among balls, hands, eyes and posture. Here, we tested whether providing additional timing information about the balls and hands motions by using external sound and tactile periodic stimulations, the later presented at the wrists, improved the behavior of jugglers. One specific combination of auditory and tactile metronome led to a decrease of the spatiotemporal variability of the juggler's performance: a simple sound associated to left and right tactile cues presented antiphase to each other, which corresponded to the temporal pattern of hands movement in the juggling task. A contrario, no improvements were obtained in the case of other auditory and tactile combinations. We even found a degraded performance when tactile events were presented alone. The nervous system thus appears able to integrate in efficient way environmental information brought by different sensory modalities, but only if the information specified matches specific features of the coordination pattern. We discuss the possible implications of these results for the understanding of the neuronal integration process implied in audio-tactile interaction in the context of complex voluntary movement, and considering the well-known gating effect of movement on vibrotactile perception.

  8. Behavioral Impact of Unisensory and Multisensory Audio-Tactile Events: Pros and Cons for Interlimb Coordination in Juggling

    Science.gov (United States)

    Zelic, Gregory; Mottet, Denis; Lagarde, Julien

    2012-01-01

    Recent behavioral neuroscience research revealed that elementary reactive behavior can be improved in the case of cross-modal sensory interactions thanks to underlying multisensory integration mechanisms. Can this benefit be generalized to an ongoing coordination of movements under severe physical constraints? We choose a juggling task to examine this question. A central issue well-known in juggling lies in establishing and maintaining a specific temporal coordination among balls, hands, eyes and posture. Here, we tested whether providing additional timing information about the balls and hands motions by using external sound and tactile periodic stimulations, the later presented at the wrists, improved the behavior of jugglers. One specific combination of auditory and tactile metronome led to a decrease of the spatiotemporal variability of the juggler's performance: a simple sound associated to left and right tactile cues presented antiphase to each other, which corresponded to the temporal pattern of hands movement in the juggling task. A contrario, no improvements were obtained in the case of other auditory and tactile combinations. We even found a degraded performance when tactile events were presented alone. The nervous system thus appears able to integrate in efficient way environmental information brought by different sensory modalities, but only if the information specified matches specific features of the coordination pattern. We discuss the possible implications of these results for the understanding of the neuronal integration process implied in audio-tactile interaction in the context of complex voluntary movement, and considering the well-known gating effect of movement on vibrotactile perception. PMID:22384211

  9. Contrasting expressions of aggressive behavior released by lesions of the central nucleus of the amygdala during wakefulness and rapid eye movement sleep without atonia in cats.

    Science.gov (United States)

    Zagrodzka, J; Hedberg, C E; Mann, G L; Morrison, A R

    1998-06-01

    Whether damage to the central nucleus of the amygdala (Ace) contributes to the predatorylike attack sometimes observed in rapid eye movement sleep without atonia (REM-A), created in cats by bilateral pontine lesions, was examined. Such lesions eliminate REM sleep skeletal muscle atonia and release elaborate behavior. Unilateral damage to the Ace alone increased affective defensive aggressive behavior toward humans and conspecifics without altering predatory behavior in wakefulness. Pontine lesions added at loci normally not leading to aggression induced predatorylike attacks in REM-A as well as the waking affective defense. Alterations of autonomic activity, the absence of relevant environmental stimuli in REM-A, or both may explain the state-related differences.

  10. Simulating Real-World Exposures during Emergency Events: Studying Effects of Indoor and Outdoor Releases in the Urban Dispersion Project in Upper Manhattan, NY

    Science.gov (United States)

    A prospective personal exposure study, involving indoor and outdoor releases, was conducted in upper Midtown Manhattan in New York City as part of the Urban Dispersion Program (UDP) focusing on atmospheric dispersion of chemicals in complex urban settings. The UDP experiments inv...

  11. Associations between recent gay-related stressful events, emotional distress, social support and unprotected anal intercourse behavior among Chinese men who have sex with men.

    Science.gov (United States)

    Yunyong, Liu; Zhe, Wang; Junting, Xu; Yan, Zhou; Xiaoxia, An; Li, Zhao; Yuan, Gu; Chao, Jiang

    2016-07-01

    This study was designed to assess the levels of and associations between gay-related stressful events, social support, emotional distress and the number of unprotected anal intercourse partners among Chinese men who have sex with men. Using a respondent-driven sampling method, 807 men who have sex with men were recruited in urban areas of northeast China and data were collected via face-to-face interviews. Gay-related stressful events were measured using the Gay-Related Stressful Life Events Scale; levels of depression, anxiety symptoms and social support were measured using the Self-Rating Depression Scale, the Self-Rating Anxiety Scale and the Social Support Rating Scale, respectively. Over a quarter of study participants experienced gay-related stressful events during the preceding 3 months. Their average Self-Rating Depression Scale, Self-Rating Anxiety Scale and Social Support scores differed significantly from the national norm. Gay-related stressful events significantly correlated with anxiety (r = 0.167, p Gay-related stressful events are common and are significantly associated with emotional distress, lack of social support and high-risk sexual behaviors among Chinese men who have sex with men. Multifaceted approaches are warranted to increase social support and reduce intolerance toward homosexual behaviors and to reduce risky sexual behaviors related to the rapid HIV epidemic among men who have sex with men population in China. © The Royal Australian and New Zealand College of Psychiatrists 2015.

  12. Length-dependent corrosion behavior, Ni2+ release, cytocompatibility, and antibacterial ability of Ni-Ti-O nanopores anodically grown on biomedical NiTi alloy.

    Science.gov (United States)

    Hang, Ruiqiang; Liu, Yanlian; Bai, Long; Zhang, Xiangyu; Huang, Xiaobo; Jia, Husheng; Tang, Bin

    2018-08-01

    In the present work, nickel-titanium-oxygen nanopores with different length (0.55-114 μm) were anodically grown on nearly equiatomic nickel-titanium (NiTi) alloy. Length-dependent corrosion behavior, nickel ion (Ni 2+ ) release, cytocompatibility, and antibacterial ability were investigated by electrochemical, analytical chemistry, and biological methods. The results show constructing nanoporous structure on the NiTi alloy improve its corrosion resistance. However, the anodized samples release more Ni 2+ than that of the bare NiTi alloy, suggesting chemical dissolution of the nanopores rather than electrochemical corrosion governs the Ni 2+ release. In addition, the Ni 2+ release amount increases with nanopore length. The anodized samples show good cytocompatibility when the nanopore length is covers the one (1-11 μm) that the nanopores showing favorable antibacterial ability. Consequently, the nanopores with length in the range of 1-11 μm are promising as coatings of biomedical NiTi alloy for anti-infection, drug delivery, and other desirable applications. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Identification of coronal heating events in 3D simulations

    Science.gov (United States)

    Kanella, Charalambos; Gudiksen, Boris V.

    2017-07-01

    Context. The solar coronal heating problem has been an open question in the science community since 1939. One of the proposed models for the transport and release of mechanical energy generated in the sub-photospheric layers and photosphere is the magnetic reconnection model that incorporates Ohmic heating, which releases a part of the energy stored in the magnetic field. In this model many unresolved flaring events occur in the solar corona, releasing enough energy to heat the corona. Aims: The problem with the verification and quantification of this model is that we cannot resolve small scale events due to limitations of the current observational instrumentation. Flaring events have scaling behavior extending from large X-class flares down to the so far unobserved nanoflares. Histograms of observable characteristics of flares show powerlaw behavior for energy release rate, size, and total energy. Depending on the powerlaw index of the energy release, nanoflares might be an important candidate for coronal heating; we seek to find that index. Methods: In this paper we employ a numerical three-dimensional (3D)-magnetohydrodynamic (MHD) simulation produced by the numerical code Bifrost, which enables us to look into smaller structures, and a new technique to identify the 3D heating events at a specific instant. The quantity we explore is the Joule heating, a term calculated directly by the code, which is explicitly correlated with the magnetic reconnection because it depends on the curl of the magnetic field. Results: We are able to identify 4136 events in a volume 24 × 24 × 9.5 Mm3 (I.e., 768 × 786 × 331 grid cells) of a specific snapshot. We find a powerlaw slope of the released energy per second equal to αP = 1.5 ± 0.02, and two powerlaw slopes of the identified volume equal to αV = 1.53 ± 0.03 and αV = 2.53 ± 0.22. The identified energy events do not represent all the released energy, but of the identified events, the total energy of the largest events

  14. Relationship between diffusivity of water molecules inside hydrating tablets and their drug release behavior elucidated by magnetic resonance imaging.

    Science.gov (United States)

    Kikuchi, Shingo; Onuki, Yoshinori; Kuribayashi, Hideto; Takayama, Kozo

    2012-01-01

    We reported previously that sustained release matrix tablets showed zero-order drug release without being affected by pH change. To understand drug release mechanisms more fully, we monitored the swelling and erosion of hydrating tablets using magnetic resonance imaging (MRI). Three different types of tablets comprised of polyion complex-forming materials and a hydroxypropyl methylcellulose (HPMC) were used. Proton density- and diffusion-weighted images of the hydrating tablets were acquired at intervals. Furthermore, apparent self-diffusion coefficient maps were generated from diffusion-weighted imaging to evaluate the state of hydrating tablets. Our findings indicated that water penetration into polyion complex tablets was faster than that into HPMC matrix tablets. In polyion complex tablets, water molecules were dispersed homogeneously and their diffusivity was relatively high, whereas in HPMC matrix tablets, water molecule movement was tightly restricted within the gel. An optimal tablet formulation determined in a previous study had water molecule penetration and diffusivity properties that appeared intermediate to those of polyion complex and HPMC matrix tablets; water molecules were capable of penetrating throughout the tablets and relatively high diffusivity was similar to that in the polyion complex tablet, whereas like the HPMC matrix tablet, it was well swollen. This study succeeded in characterizing the tablet hydration process. MRI provides profound insight into the state of water molecules in hydrating tablets; thus, it is a useful tool for understanding drug release mechanisms at a molecular level.

  15. Serial assessment of the physiological status of leatherback turtles (Dermochelys coriacea) during direct capture events in the northwestern Atlantic Ocean: comparison of post-capture and pre-release data.

    Science.gov (United States)

    Innis, Charles J; Merigo, Constance; Cavin, Julie M; Hunt, Kathleen; Dodge, Kara L; Lutcavage, Molly

    2014-01-01

    The physiological status of seven leatherback turtles (Dermochelys coriacea) was assessed at two time points during ecological research capture events in the northwestern Atlantic Ocean. Data were collected as soon as possible after securing each turtle onboard the capture vessel and again immediately prior to release. Measured parameters included sea surface temperature, body temperature, morphometric data, sex, heart rate, respiratory rate and various haematological and blood biochemical variables. Results indicated generally stable physiological status in comparison to previously published studies of this species. However, blood pH and blood potassium concentrations increased significantly between the two time points (P = 0.0018 and P = 0.0452, respectively). Turtles were affected by a mild initial acidosis (mean [SD] temperature-corrected pH = 7.29 [0.07]), and blood pH increased prior to release (mean [SD] = 7.39 [0.07]). Initial blood potassium concentrations were considered normal (mean [SD] = 4.2 [0.9] mmol/l), but turtles experienced a mild to moderate increase in blood potassium concentrations during the event (mean [SD] pre-release potassium = 5.9 [1.7] mmol/l, maximum = 8.5 mmol/l). While these data support the general safety of direct capture for study of this species, the observed changes in blood potassium concentrations are of potential concern due to possible adverse effects of hyperkalaemia on cardiac function. The results of this study highlight the importance of physiological monitoring during scientific capture events. The results are also likely to be relevant to unintentional leatherback capture events (e.g. fisheries interactions), when interactions may be more prolonged or extreme.

  16. Functionality Effect of Pressure Sensitive Adhesives on In Vitro Drug Release Behavior of Fentanyl Drug in an Adhesive Patch

    Directory of Open Access Journals (Sweden)

    S.M. Taghizadeh

    2009-12-01

    Full Text Available Some formulations of drug in adhesive transdermal drug delivery systems (TDDSs( with different functional and non-functional acrylic pressure sensitive adhesives PSAs( were prepared. For this purpose fentanyl was used as a drug component. The effects of PSAs type on skin permeation and in vitro drug release from devices were evaluated using hydrodynamically well-characterized Chien permeation system fitted with excised rat abdominal skin. The adhesion properties of devices (peel strength and tack values( were obtained. It was found that TDDS with –COOH functional PSA had the lowest steady state flux. Drug release was followed by Higuchi's kinetic model. Adhesion properties of the samples were improved by addition of functional PSA in the formulations.

  17. Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol

    Energy Technology Data Exchange (ETDEWEB)

    Llorens, E.; Ibañez, H. [Departament d' Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona E-08028 (Spain); Valle, L.J. del, E-mail: luis.javier.del.valle@upc.edu [Departament d' Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona E-08028 (Spain); Puiggalí, J. [Departament d' Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona E-08028 (Spain); Center for Research in Nano-Engineering (CrNE), Universitat Politècnica de Catalunya, Edifici C, C/Pasqual i Vila s/n, Barcelona E-08028 (Spain)

    2015-04-01

    Scaffolds constituted by electrospun microfibers of poly(ethylene glycol) (PEG) and poly(butylene succinate) (PBS) were studied. Specifically, coaxial microfibers having different core–shell distributions and compositions were considered as well as uniaxial micro/nanofibers prepared from mixtures of both polymers. Processing conditions were optimized for all geometries and compositions and resulting morphologies (i.e. diameter and surface texture) characterized by scanning electron microscopy. Chemical composition, molecular interactions and thermal properties were evaluated by FTIR, NMR, XPS and differential scanning calorimetry. The PEG component of electrospun fibers could be solubilized by immersion of scaffolds in aqueous medium, giving rise to high porosity and hydrophobic samples. Nevertheless, a small amount of PEG was retained in the PBS matrix, suggesting some degree of mixing. Solubilization was slightly dependent on fiber structure; specifically, the distribution of PEG in the core or shell of coaxial fibers led to higher or lower retention levels, respectively. Scaffolds could be effectively loaded with hydrophobic drugs having antibacterial and anticarcinogenic activities like triclosan and curcumin, respectively. Their release was highly dependent on their chemical structure and medium composition. Thus, low and high release rates were observed in phosphate buffer saline (SS) and SS/ethanol (30:70 v/v), respectively. Slight differences in the release of triclosan were found depending on fiber distribution and composition. Antibacterial activity and biocompatibility were evaluated for both loaded and unloaded scaffolds. - Highlights: • Coaxial microfibers with different hydrophobicities were studied. • The surface morphology of the coaxial fiber shows the distribution of polymers. • Coaxial fiber microstructure favors the polymer molecular orientation. • These hybrid materials have greater advantages for loading and drug release. • PEG

  18. Effect of pullulan nanoparticle surface charges on HSA complexation and drug release behavior of HSA-bound nanoparticles.

    Directory of Open Access Journals (Sweden)

    Xiaojun Tao

    Full Text Available Nanoparticle (NP compositions such as hydrophobicity and surface charge are vital to determine the presence and amount of human serum albumin (HSA binding. The HSA binding influences drug release, biocompatibility, biodistribution, and intercellular trafficking of nanoparticles (NPs. Here, we prepared 2 kinds of nanomaterials to investigate HSA binding and evaluated drug release of HSA-bound NPs. Polysaccharides (pullulan carboxyethylated to provide ionic derivatives were then conjugated to cholesterol groups to obtain cholesterol-modified carboxyethyl pullulan (CHCP. Cholesterol-modified pullulan (CHP conjugate was synthesized with a similar degree of substitution of cholesterol moiety to CHCP. CHCP formed self-aggregated NPs in aqueous solution with a spherical structure and zeta potential of -19.9 ± 0.23 mV, in contrast to -1.21 ± 0.12 mV of CHP NPs. NPs could quench albumin fluorescence intensity with maximum emission intensity gradually decreasing up to a plateau at 9 to 12 h. Binding constants were 1.12 × 10(5 M(-1 and 0.70 × 10(5 M(-1 to CHP and CHCP, respectively, as determined by Stern-Volmer analysis. The complexation between HSA and NPs was a gradual process driven by hydrophobic force and inhibited by NP surface charge and shell-core structure. HSA conformation was altered by NPs with reduction of α-helical content, depending on interaction time and particle surface charges. These NPs could represent a sustained release carrier for mitoxantrone in vitro, and the bound HSA assisted in enhancing sustained drug release.

  19. Serviceability and Prestress Loss Behavior of SCC Prestressed Concrete Girders Subjected to Increased Compressive Stresses at Release

    Science.gov (United States)

    2009-08-01

    There are limited measurements documented in the literature related to long-term prestress losses in self-consolidated concrete (SCC) members. Recorded test data has shown variations in mechanical property behavior of SCC compared to conventional HSC...

  20. Tritium release behavior from neutron-irradiated Li{sub 2}TiO{sub 3} single crystal

    Energy Technology Data Exchange (ETDEWEB)

    Tanifuji, Takaaki; Yamaki, Daiju; Noda, Kenji [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Nasu, Shoichi

    1998-03-01

    Li{sub 2}TiO{sub 3} single-crystals with various size (1-2mm) were used as specimens. After the irradiation up to 4 x 10{sup 18} n/cm{sup 2} with thermal neutrons in JRR-2, tritium release from the Li{sub 2}TiO{sub 3} specimens in isothermal heating tests was continuously measured with a proportional counter. The tritium release in the range from 625K to 1373K seems to be controlled by bulk diffusion. The tritium diffusion coefficient (D{sub T}) in Li{sub 2}TiO{sub 3} was evaluated to be D{sub T}(cm{sup 2}/sec) = 0.100exp(-104(kJ/mol)/RT), 625Krelease performance of Li{sub 2}TiO{sub 3} is essentially good as Li{sub 2}O. (author)

  1. Adverse Life Events and Emotional and Behavioral Problems in Adolescence: The Role of Non-Verbal Cognitive Ability and Negative Cognitive Errors

    Science.gov (United States)

    Flouri, Eirini; Panourgia, Constantina

    2011-01-01

    The aim of this study was to test whether negative cognitive errors (overgeneralizing, catastrophizing, selective abstraction, and personalizing) mediate the moderator effect of non-verbal cognitive ability on the association between adverse life events (life stress) and emotional and behavioral problems in adolescence. The sample consisted of 430…

  2. The Phonotactic Influence on the Perception of a Consonant Cluster /pt/ by Native English and Native Polish Listeners: A Behavioral and Event Related Potential (ERP) Study

    Science.gov (United States)

    Wagner, Monica; Shafer, Valerie L.; Martin, Brett; Steinschneider, Mitchell

    2012-01-01

    The effect of exposure to the contextual features of the /pt/ cluster was investigated in native-English and native-Polish listeners using behavioral and event-related potential (ERP) methodology. Both groups experience the /pt/ cluster in their languages, but only the Polish group experiences the cluster in the context of word onset examined in…

  3. Dynamic changes in extracellular release of GABA and glutamate in the lateral septum during social play behavior in juvenile rats: Implications for sex-specific regulation of social play behavior

    Science.gov (United States)

    Bredewold, Remco; Schiavo, Jennifer K.; van der Hart, Marieke; Verreij, Michelle; Veenema, Alexa H.

    2015-01-01

    Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulation of social play behavior in juvenile male and female rats. The LS is largely modulated by GABA and glutamate neurotransmission, but their role in social play behavior is unknown. Here, we determined whether social play behavior is associated with changes in the extracellular release of GABA and glutamate in the LS and to what extent such changes modulate social play behavior in male and female juvenile rats. Using intracerebral microdialysis in freely behaving rats, we found no sex difference in extracellular GABA concentrations, but extracellular glutamate concentrations are higher in males than in females under baseline condition and during social play. This resulted in a higher glutamate/GABA concentration ratio in males versus females and thus, an excitatory predominance in the LS of males. Furthermore, social play behavior in both sexes is associated with significant increases in extracellular release of GABA and glutamate in the LS. Pharmacological blockade of GABA-A receptors in the LS with bicuculline (100 ng/0.5 µl, 250 ng/0.5 µl) dose-dependently decreased the duration of social play behavior in both sexes. In contrast, pharmacological blockade of ionotropic glutamate receptors (NMDA and AMPA/kainate receptors) in the LS with AP-5 + CNQX (2 mM+0.4 mM/0.5 µl, 30 mM+3 mM/0.5 µl) dose-dependently decreased the duration of social play behavior in females, but did not alter social play behavior in males. Together, these data suggest a role for GABA neurotransmission in the LS in the regulation of juvenile social play behavior in both sexes, while glutamate neurotransmission in the LS is involved in the sex-specific regulation of juvenile

  4. Environmental significance of copper, lead, manganese, uranium and zinc speciation in the event of contaminated waters release from the Ranger Uranium Mining Complex

    International Nuclear Information System (INIS)

    Noller, B.N.; Currey, N.A.

    1983-01-01

    The likely impact of the accidental release of tailings dam water during the dry season at the Ranger Uranium Mining Complex was examined. A speciation scheme utilising sizing by filtration and ion-exchange with Chelex 100 has given an insight into the likely partitioning of zinc, copper, lead, manganese and uranium following the addition of tailings dam water to samples from waterbodies in the vicinity of the uranium mining/milling complex. The speciation findings are discussed in terms of likely toxic effects on fish

  5. Differentiation Affects the Release of Exosomes from Colon Cancer Cells and Their Ability to Modulate the Behavior of Recipient Cells.

    Science.gov (United States)

    Lucchetti, Donatella; Calapà, Federica; Palmieri, Valentina; Fanali, Caterina; Carbone, Federica; Papa, Alfredo; De Maria, Ruggero; De Spirito, Marco; Sgambato, Alessandro

    2017-07-01

    Exosomes are involved in intercellular communication. We previously reported that sodium butyrate-induced differentiation of HT29 colon cancer cells is associated with a reduced CD133 expression. Herein, we analyzed the role of exosomes in the differentiation of HT29 cells. Exosomes were prepared using ultracentrifugation. Gene expression levels were evaluated by real-time PCR. The cell proliferation rate was assessed by MTT assay and with the electric cell-substrate impedance sensing system, whereas cell motility was assessed using the scratch test and confocal microscopy. Sodium butyrate-induced differentiation of HT29 and Caco-2 cells increased the levels of released exosomes and their expression of CD133. Cell differentiation and the decrease of cellular CD133 expression levels were prevented by blocking multivesicular body maturation. Exosomes released by HT29 differentiating cells carried increased levels of miRNAs, induced an increased proliferation and motility of both colon cancer cells and normal fibroblasts, increased the colony-forming efficiency of cancer cells, and reduced the sodium butyrate-induced differentiation of HT29 cells. Such effects were associated with an increased phosphorylation level of both Src and extracellular signal regulated kinase proteins and with an increased expression of epithelial-to-mesenchymal transition-related genes. Release of exosomes is affected by differentiation of colon cancer cells; exosomes might be used by differentiating cells to get rid of components that are no longer necessary but might continue to exert their effects on recipient cells. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  6. Surface Modification of NiTi Alloy via Cathodic Plasma Electrolytic Deposition and its Effect on Ni Ion Release and Osteoblast Behaviors

    International Nuclear Information System (INIS)

    Yan Ying; Cai Kaiyong; Yang Weihu; Liu Peng

    2013-01-01

    To reduce Ni ion release and improve biocompatibility of NiTi alloy, the cathodic plasma electrolytic deposition (CPED) technique was used to fabricate ceramic coating onto a NiTi alloy surface. The formation of a coating with a rough and micro-textured surface was confirmed by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, respectively. An inductively coupled plasma mass spectrometry test showed that the formed coating significantly reduced the release of Ni ions from the NiTi alloy in simulated body fluid. The influence of CPED treated NiTi substrates on the biological behaviors of osteoblasts, including cell adhesion, cell viability, and osteogenic differentiation function (alkaline phosphatase), was investigated in vitro. Immunofluorescence staining of nuclei revealed that the CPED treated NiTi alloy was favorable for cell growth. Osteoblasts on CPED modified NiTi alloy showed greater cell viability than those for the native NiTi substrate after 4 and 7 days cultures. More importantly, osteoblasts cultured onto a modified NiTi sample displayed significantly higher differentiation levels of alkaline phosphatase. The results suggested that surface functionalization of NiTi alloy with ceramic coating via the CPED technique was beneficial for cell proliferation and differentiation. The approach presented here is useful for NiTi implants to enhance bone osteointegration and reduce Ni ion release in vitro

  7. Surface Modification of NiTi Alloy via Cathodic Plasma Electrolytic Deposition and its Effect on Ni Ion Release and Osteoblast Behaviors

    Science.gov (United States)

    Yan, Ying; Cai, Kaiyong; Yang, Weihu; Liu, Peng

    2013-07-01

    To reduce Ni ion release and improve biocompatibility of NiTi alloy, the cathodic plasma electrolytic deposition (CPED) technique was used to fabricate ceramic coating onto a NiTi alloy surface. The formation of a coating with a rough and micro-textured surface was confirmed by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, respectively. An inductively coupled plasma mass spectrometry test showed that the formed coating significantly reduced the release of Ni ions from the NiTi alloy in simulated body fluid. The influence of CPED treated NiTi substrates on the biological behaviors of osteoblasts, including cell adhesion, cell viability, and osteogenic differentiation function (alkaline phosphatase), was investigated in vitro. Immunofluorescence staining of nuclei revealed that the CPED treated NiTi alloy was favorable for cell growth. Osteoblasts on CPED modified NiTi alloy showed greater cell viability than those for the native NiTi substrate after 4 and 7 days cultures. More importantly, osteoblasts cultured onto a modified NiTi sample displayed significantly higher differentiation levels of alkaline phosphatase. The results suggested that surface functionalization of NiTi alloy with ceramic coating via the CPED technique was beneficial for cell proliferation and differentiation. The approach presented here is useful for NiTi implants to enhance bone osseointegration and reduce Ni ion release in vitro.

  8. Loss of Sh3gl2/Endophilin A1 Is a Common Event in Urothelial Carcinoma that Promotes Malignant Behavior

    Directory of Open Access Journals (Sweden)

    Shyama Majumdar

    2013-07-01

    Full Text Available Urothelial carcinoma (UC causes substantial morbidity and mortality worldwide. However, the molecular mechanisms underlying urothelial cancer development and tumor progression are still largely unknown. Using informatics analysis, we identified Sh3gl2 (endophilin A1 as a bladder urothelium-enriched transcript. The gene encoding Sh3gl2 is located on chromosome 9p, a region frequently altered in UC. Sh3gl2 is known to regulate endocytosis of receptor tyrosine kinases implicated in oncogenesis, such as the epidermal growth factor receptor (EGFR and c-Met. However, its role in UC pathogenesis is unknown. Informatics analysis of expression profiles as well as immunohistochemical staining of tissue microarrays revealed Sh3gl2 expression to be decreased in UC specimens compared to nontumor tissues. Loss of Sh3gl2 was associated with increasing tumor grade and with muscle invasion, which is a reliable predictor of metastatic disease and cancer-derived mortality. Sh3gl2 expression was undetectable in 19 of 20 human UC cell lines but preserved in the low-grade cell line RT4. Stable silencing of Sh3gl2 in RT4 cells by RNA interference 1 enhanced proliferation and colony formation in vitro, 2 inhibited EGF-induced EGFR internalization and increased EGFR activation, 3 stimulated phosphorylation of Src family kinases and STAT3, and 4 promoted growth of RT4 xenografts in subrenal capsule tissue recombination experiments. Conversely, forced re-expression of Sh3gl2 in T24 cells and silenced RT4 clones attenuated oncogenic behaviors, including growth and migration. Together, these findings identify loss of Sh3gl2 as a frequent event in UC development that promotes disease progression.

  9. Sexual dimorphism of gonadotropin-releasing hormone type-III (GnRH3) neurons and hormonal sex reversal of male reproductive behavior in Mozambique tilapia.

    Science.gov (United States)

    Kuramochi, Asami; Tsutiya, Atsuhiro; Kaneko, Toyoji; Ohtani-Kaneko, Ritsuko

    2011-10-01

    In tilapia, hormone treatment during the period of sexual differentiation can alter the phenotype of the gonads, indicating that endocrine factors can cause gonadal sex reversal. However, the endocrine mechanism underlying sex reversal of reproductive behaviors remains unsolved. In the present study, we detected sexual dimorphism of gonadotropin-releasing hormone type III (GnRH3) neurons in Mozambique tilapia Oreochromis mossambicus. Our immunohistochemical observations showed sex differences in the number of GnRH3 immunoreactive neurons in mature tilapia; males had a greater number of GnRH3 neurons in the terminal ganglion than females. Treatment with androgen (11-ketotestosterone (11-KT) or methyltestosterone), but not that with 17β-estradiol, increased the number of GnRH3 neurons in females to a level similar to that in males. Furthermore, male-specific nest-building behavior was induced in 70% of females treated with 11-KT within two weeks after the onset of the treatment. These results indicate androgen-dependent regulation of GnRH3 neurons and nest-building behavior, suggesting that GnRH3 is importantly involved in sex reversal of male-specific reproductive behavior.

  10. Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound.

    Science.gov (United States)

    Abdul Latip, Ahmad Faiz; Hussein, Mohd Zobir; Stanslas, Johnson; Wong, Charng Choon; Adnan, Rohana

    2013-01-01

    Layered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique anion exchange properties. In this work, layered zinc hydroxide nitrate (LZH), a family member of LHS was intercalated with anionic ciprofloxacin (CFX), a broad spectrum antibiotic via ion exchange in a mixture solution of water:ethanol. Powder x-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the drug anions were successfully intercalated in the interlayer space of LZH. Specific surface area of the obtained compound was increased compared to that of the host due to the different pore textures between the two materials. CFX anions were slowly released over 80 hours in phosphate-buffered saline (PBS) solution due to strong interactions that occurred between the intercalated anions and the host lattices. The intercalation compound demonstrated enhanced antiproliferative effects towards A549 cancer cells compared to the toxicity of CFX alone. Strong host-guest interactions between the LZH lattice and the CFX anion give rise to a new intercalation compound that demonstrates sustained release mode and enhanced toxicity effects towards A549 cell lines. These findings should serve as foundations towards further developments of the brucite-like host material in drug delivery systems.

  11. Characterization of the gas releasing behaviors of catalytic pyrolysis of rice husk using potassium over a micro-fluidized bed reactor

    International Nuclear Information System (INIS)

    Liu, Yuan; Wang, Yan; Guo, Feiqiang; Li, Xiaolei; Li, Tiantao; Guo, Chenglong; Chang, Jiafu

    2017-01-01

    Highlights: • Releasing propensity of CO, CO 2 , CH 4 and H 2 was studied in a micro-fluidized bed. • Gas releasing pattern was influenced by temperature and potassium concentration. • Variations in gas forming E a are indicative of catalytic performance of potassium. - Abstract: Influence of potassium on the gas releasing behaviors during rice husk high-temperature pyrolysis was investigated under isothermal conditions in a two stage micro-fluidized bed reactor. Reaction kinetics for generating H 2 , CO, CO 2 and CH 4 was investigated based on the Friedman and model-fitting approaches. Results indicated that different gas species had different times to start and end the gas release process, particularly at 600 °C, representing different chemical routes and mechanics for generating these gas components. The resulting apparent activation energies for H 2 , CO, and CO 2 decreased from 23.10 to 12.00 kJ/mol, 15.48 to 14.03 kJ/mol and 10.14 to 7.61 kJ/mol respectively with an increase in potassium concentration from 0 to 0.5 mol/kg, while that for CH 4 increased from 16.85 to 19.40 kJ/mol. The results indicated that the addition of potassium could promote the generation reactions of H 2 , CO and CO 2 while hinder the generation reactions of CH 4 . The pyrolysis reaction was further found to be subject to the three-dimensional diffusion model for all the samples.

  12. Behavior and movement of adult summer steelhead following collection and release, lower Cowlitz River, Washington, 2012--2013

    Science.gov (United States)

    Kock, Tobias J.; Liedtke, Theresa L.; Ekstrom, Brian K.; Rondorf, Dennis W.; Gleizes, Chris; Dammers, Wolf; Gibson, Scott; Murphy, Jamie

    2013-01-01

    Executive SummaryHistorically, adult summer steelhead Oncorhynchus mykiss returning to hatcheries on the lower Cowlitz River were sometimes transported and released in the river (recycled) to provide additional angling opportunity for the popular sport fishery in the basin. However, this practice has not been used in recent years because of concerns associated with interactions between hatchery fish and wild fish. Fishery managers were interested in resuming recycling but lacked information regarding effects of this practice on wild steelhead so we conducted a study during 2012–2013 to: (1) enumerate recycled steelhead that returned to the hatchery or were removed by anglers; and (2) determine if steelhead that were not removed from the river remained in the system where they could interact with wild fish.During June–August 2012, a total of 549 summer steelhead were captured at the Cowlitz Salmon Hatchery, tagged, and released downstream near the Interstate 5 Bridge. All recycled steelhead were tagged with a white Floy® tag and opercle-punched; 109 (20 percent) of these fish also were radio-tagged. All adult steelhead that return to the hatchery were handled by hatchery staff so recycled steelhead that returned to the hatchery were enumerated daily. A creel survey and voluntary angler reports were used to determine the number of recycled steelhead that were caught by anglers. We established three fixed telemetry monitoring sites on the mainstem Cowlitz River and eight additional sites were deployed on tributaries to the lower Cowlitz River where wild winter steelhead are known to spawn. We also conducted mobile tracking from a boat during October 2012, November 2012, and January 2013 to locate radio-tagged fish.A total of 10,722 summer steelhead were captured at the Cowlitz Salmon Hatchery in 2012, which was the largest return since 2008. River flows during much of the study period were similar to 2008–2011 average flows, however, high-flow periods in July

  13. Simulating the influence of life trajectory events on transport mode behavior in an agent-based system

    NARCIS (Netherlands)

    Verhoeven, M.; Arentze, T.A.; Timmermans, H.J.P.; Waerden, van der P.J.H.J.

    2007-01-01

    this paper describes the results of a study on the impact of lifecycle or life trajectory events on activity-travel decisions. This lifecycle trajectory of individual agents can be easily incorporated in an agent-based simulation system. This paper focuses on two lifecycle events, change in

  14. Nuclide Release Behavior from a Repository for a Pyro-process HLW and SF due to Variation of the MWCF Properties

    International Nuclear Information System (INIS)

    Lee, Youn Myoung; Hwang, Yong Soo

    2009-01-01

    An assessment program for an optional evaluation of a repository both for disposal of such high-level wastes (HLWs) from various steps of pyro-processes of PWR spent nuclear fuel (SF) and for direct disposal of PWR and CANDU SFs has been developed by utilizing general purpose GoldSim developing tool, by which nuclide transports in the near- and far-field of a repository as well as a transport through a biosphere under various natural and manmade disruptive events affecting a nuclide release could be modeled and evaluated. KAERI has been in charge of modeling and developing assessment tools by which the above mentioned repository system could be assessed in accordance with various features, events, and processes (FEPs) that could happen in and around the repository system. To cope with such various natural and manmade disruptive FEPs as well as normal release scenarios, all the possible cases in view of the Korean circumstances should be modeled and have been evaluated even though we have not yet have any repository. A possible case, among many others, with the variation of such physical properties as the fracture width and the rock matrix diffusion depth, associated with the natural fractures in the geological rock media, along which nuclide could be transported preferentially with the flow of groundwater is considered in the current study. Due to whatever the reason, such as e,g., the earthquake or human intrusion, it is assumed that the physical properties of the major water conducting fault (MWCF) is changed resulting in the size of fracture width and the matrix diffusion depth. For such case another illustration is made for probabilistic evaluation of a hypothetical Korean HLW repository, as similarly done in the previous studies

  15. Noise stress changes mRNA expressions of corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors

    Directory of Open Access Journals (Sweden)

    Evren Eraslan

    2015-01-01

    Full Text Available Noise is a psychological, environmental stressor that activates limbic sites in the brain. Limbic sites such as the amygdala and the amygdaloid corticotropin-releasing hormone (CRH system play an important role in integrating stress response. We investigated the association between noise exposures, CRH-related molecules in the amygdala, and behavioral alterations. In total 54 Sprague-Dawley rats were divided into the following three groups: Control (CON, acute noise exposure (ANE, and chronic noise exposure (CNE. The ANE group was exposed to 100 dB white noise only once in 4 h and the CNE group was exposed to the same for 4 h per day for 30 days. Expression profiles of CRH and its receptors CRH-R1 and CRH-R2 were analyzed by quantitative real-time polymerase chain reaction (qPCR. The same stress procedure was applied to the ANE and CNE groups for behavior testing. The anxiety responses of the animals after acute and chronic stress exposure were measured in the defensive withdrawal test. CNE upregulated CRH and CRH-R1 mRNA levels but downregulated CRH-R2 mRNA levels. ANE led to a decrease in both CRH-R1 and CRH-R2 expression. In the defensive withdrawal test, while the ANE increased, CNE reduced anxiety-like behaviors. The present study shows that the exposure of rats to white noise (100 dB leads to behavioral alterations and molecule-specific changes in the CRH system. Behavioral alterations can be related to these molecular changes in the amygdala.

  16. Noise stress changes mRNA expressions of corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors.

    Science.gov (United States)

    Eraslan, Evren; Akyazi, Ibrahim; Erg L-Ekiz, Elif; Matur, Erdal

    2015-01-01

    Noise is a psychological, environmental stressor that activates limbic sites in the brain. Limbic sites such as the amygdala and the amygdaloid corticotropin-releasing hormone (CRH) system play an important role in integrating stress response. We investigated the association between noise exposures, CRH-related molecules in the amygdala, and behavioral alterations. In total 54 Sprague-Dawley rats were divided into the following three groups: Control (CON), acute noise exposure (ANE), and chronic noise exposure (CNE). The ANE group was exposed to 100 dB white noise only once in 4 h and the CNE group was exposed to the same for 4 h per day for 30 days. Expression profiles of CRH and its receptors CRH-R1 and CRH-R2 were analyzed by quantitative real-time polymerase chain reaction (qPCR). The same stress procedure was applied to the ANE and CNE groups for behavior testing. The anxiety responses of the animals after acute and chronic stress exposure were measured in the defensive withdrawal test. CNE upregulated CRH and CRH-R1 mRNA levels but downregulated CRH-R2 mRNA levels. ANE led to a decrease in both CRH-R1 and CRH-R2 expression. In the defensive withdrawal test, while the ANE increased, CNE reduced anxiety-like behaviors. The present study shows that the exposure of rats to white noise (100 dB) leads to behavioral alterations and molecule-specific changes in the CRH system. Behavioral alterations can be related to these molecular changes in the amygdala.

  17. Mussel-inspired fabrication of konjac glucomannan/microcrystalline cellulose intelligent hydrogel with pH-responsive sustained release behavior.

    Science.gov (United States)

    Wang, Lin; Du, Yu; Yuan, Yi; Mu, Ruo-Jun; Gong, Jingni; Ni, Yongsheng; Pang, Jie; Wu, Chunhua

    2018-07-01

    Intelligent hydrogels are attractive biomaterials for various applications, however, fabricating a hydrogel with both adequate self-healing ability and mechanical properties remains a challenge. Herein, a series of novel intelligent konjac glucomannan (KGM)/microcrystalline cellulose (MCC) hydrogels were prepared vis the mussel-inspired chemistry. MCC was firstly functionalized by the oxidative polymerization of dopamine, and the intelligent hydrogels were obtained by mixing aqueous solutions of KGM and functionalized MCC (PDMCC). By introducing PDMCC, a more compact interconnected porous structure formed for the resulting hydrogels. The self-healing ability and mechanical properties of intelligent hydrogels were dependence on the PDMCC content. Compared with KGM hydrogels, KGM/PDMCC hydrogels exhibited a more distinct pH sensitivity and a lower initial burst release, which was attributed to the compact structure and strong intermolecular hydrogen bond interaction between PDMCC and KGM. These results suggest that the KGM/PDMCC intelligent hydrogels may be promising carriers for controlled drug delivery. Copyright © 2018 Elsevier B.V. All rights reserved.

  18. Psychopathology and prosocial behavior in adolescents from socio-economically disadvantaged families: the role of proximal and distal adverse life events.

    Science.gov (United States)

    Flouri, Eirini; Tzavidis, Nikos

    2008-12-01

    The study investigated if proximal contextual risk (number of adverse life events experienced in the last year) or distal contextual risk (number of adverse life events experienced before the last year) is a better predictor of adolescent psychopathology and prosocial behavior. It also tested for the specificity, accumulation and gradient of contextual risk in psychopathology and prosocial behavior, and for the interaction between proximal and distal contextual risk in psychopathology and prosocial behavior. The sample was 199 11-18 year old children from a socio-economically disadvantaged area in North-East London. The Strengths and Difficulties Questionnaire (SDQ), which measures four difficulties (hyperactivity, emotional symptoms, conduct problems, and peer problems) and prosocial behavior, was used. Confounders were age, gender, and maternal educational qualifications. To model the relationship between the five SDQ scales and contextual risk multivariate response regression models and multivariate response logistic regression models that allow the error terms of the scale specific models to be correlated were fitted. This study highlighted the importance of proximal contextual risk in predicting both broad and externalizing psychopathology, and the importance of considering risk accumulation rather than specificity in predicting psychopathology. By showing that the number of proximal adverse life events experienced had a steady, additive effect on broad and externalizing psychopathology, it also highlighted the need to protect adolescents experiencing current risk from further risk exposure. By showing that the number of distal adverse life events experienced did not affect the proximal risk's impact on either broad or externalizing psychopathology, it highlighted the need to protect all adolescents, irrespective of experience of early life adversities, from risk.

  19. A prospective study of the sexual, emotional and behavioral correlates associated with young women’s first and usual coital events

    Science.gov (United States)

    Tanner, Amanda E.; Hansel, Devon J.; Fortenberry, J. Dennis

    2010-01-01

    Context First coitus is considered a major transitional event imbued with cultural relevance. Research has focused on classifying women as virgins with the primary interest in pregnancy and STI prevention and less on sexuality. This study prospectively explored young women’s sexual interest and love at first and subsequent coitus. Methods Daily diary data were collected during a longitudinal study of young women’s sexual health (N=387; 14–17 years at enrollment). Variables of interest included sexual interest, love, and contraceptive and disease prevention behaviors. ANOVA and bootstrapping analytic techniques were utilized. Results For first coital events, love and sexual interest were reported about ‘half of the day’ with sexual interest significantly higher on the day of first coitus. Condom use was nine times more likely than no method at first compared to later coital events. For subsequent coitus, feeling in love was significantly higher compared to first coitus with average sexual interest and love significantly higher with use of no contraceptive method over condoms. Condoms were associated with higher feelings of being in love, but lower sexual interest compared to hormonal contraception. Conclusions The results indicated that sexual interest and love are independent components of coital behavior. Yet the results also suggest that young women’s first coitus does not fully capture the expected significance of ‘losing one’s virginity.’ Thus, at first coitus women can actively engage in protective behaviors and focus on pleasure. PMID:20547288

  20. When Fiction Is Just as Real as Fact: No Differences in Reading Behavior between Stories Believed to be Based on True or Fictional Events

    Science.gov (United States)

    Hartung, Franziska; Withers, Peter; Hagoort, Peter; Willems, Roel M.

    2017-01-01

    Experiments have shown that compared to fictional texts, readers read factual texts faster and have better memory for described situations. Reading fictional texts on the other hand seems to improve memory for exact wordings and expressions. Most of these studies used a “newspaper” vs. “literature” comparison. In the present study, we investigated the effect of reader's expectation to whether information is true or fictional with a subtler manipulation by labeling short stories as either based on true or fictional events. In addition, we tested whether narrative perspective or individual preference in perspective taking affects reading true or fictional stories differently. In an online experiment, participants (final N = 1,742) read one story which was introduced as based on true events or as fictional (factor fictionality). The story could be narrated in either 1st or 3rd person perspective (factor perspective). We measured immersion in and appreciation of the story, perspective taking, as well as memory for events. We found no evidence that knowing a story is fictional or based on true events influences reading behavior or experiential aspects of reading. We suggest that it is not whether a story is true or fictional, but rather expectations toward certain reading situations (e.g., reading newspaper or literature) which affect behavior by activating appropriate reading goals. Results further confirm that narrative perspective partially influences perspective taking and experiential aspects of reading. PMID:28983269

  1. When Fiction Is Just as Real as Fact: No Differences in Reading Behavior between Stories Believed to be Based on True or Fictional Events

    Directory of Open Access Journals (Sweden)

    Franziska Hartung

    2017-09-01

    Full Text Available Experiments have shown that compared to fictional texts, readers read factual texts faster and have better memory for described situations. Reading fictional texts on the other hand seems to improve memory for exact wordings and expressions. Most of these studies used a “newspaper” vs. “literature” comparison. In the present study, we investigated the effect of reader's expectation to whether information is true or fictional with a subtler manipulation by labeling short stories as either based on true or fictional events. In addition, we tested whether narrative perspective or individual preference in perspective taking affects reading true or fictional stories differently. In an online experiment, participants (final N = 1,742 read one story which was introduced as based on true events or as fictional (factor fictionality. The story could be narrated in either 1st or 3rd person perspective (factor perspective. We measured immersion in and appreciation of the story, perspective taking, as well as memory for events. We found no evidence that knowing a story is fictional or based on true events influences reading behavior or experiential aspects of reading. We suggest that it is not whether a story is true or fictional, but rather expectations toward certain reading situations (e.g., reading newspaper or literature which affect behavior by activating appropriate reading goals. Results further confirm that narrative perspective partially influences perspective taking and experiential aspects of reading.

  2. The effect of Nb addition on mechanical properties, corrosion behavior, and metal-ion release of ZrAlCuNi bulk metallic glasses in artificial body fluid.

    Science.gov (United States)

    Qiu, C L; Liu, L; Sun, M; Zhang, S M

    2005-12-15

    Bulk metallic glasses (BMGs) of Zr(65 - x)Nb(x)- Cu(17.5)Ni(10)Al(7.5) with Nb = 0, 2, and 5 at % were prepared by copper mold casting. Compression tests reveal that the two BMGs containing Nb exhibited superior strength and plasticity to the base alloy. The corrosion behavior of the alloys obtained was investigated in artificial body fluid by electrochemical measurements. It was found that the addition of Nb significantly enhanced the corrosion resistance of the Zr-based BMG, as indicated by a remarkable increase in corrosion potential and pitting potential. XPS analysis revealed that the passive film formed after anodic polarization was enriched in aluminum oxide and depleted in phosphate ions for the BMGs containing Nb, which accounts for the improvement of corrosion resistance. On the other hand, metal-ion release of different BMGs were determined in PPb (ng/mL) level with inductively coupled plasma mass spectrometry (ICP-MS) after being immersed in artificial body fluid at 37 degrees C for 20 days. It was found that the addition of Nb considerably reduced the ion release of all kinds of metals of the base system. This is probably attributed to the promoting effect of Nb on a rapid formation of highly protective film.

  3. Gonadotropin-releasing hormone receptor (Gnrhr gene knock out: Normal growth and development of sensory, motor and spatial orientation behavior but altered metabolism in neonatal and prepubertal mice.

    Directory of Open Access Journals (Sweden)

    Ellen R Busby

    Full Text Available Gonadotropin-releasing hormone (GnRH is important in the control of reproduction, but its actions in non-reproductive processes are less well known. In this study we examined the effect of disrupting the GnRH receptor in mice to determine if growth, metabolism or behaviors that are not associated with reproduction were affected. To minimize the effects of other hormones such as FSH, LH and sex steroids, the neonatal-prepubertal period of 2 to 28 days of age was selected. The study shows that regardless of sex or phenotype in the Gnrhr gene knockout line, there was no significant difference in the daily development of motor control, sensory detection or spatial orientation among the wildtype, heterozygous or null mice. This included a series of behavioral tests for touch, vision, hearing, spatial orientation, locomotory behavior and muscle strength. Neither the daily body weight nor the final weight on day 28 of the kidney, liver and thymus relative to body weight varied significantly in any group. However by day 28, metabolic changes in the GnRH null females compared with wildtype females showed a significant reduction in inguinal fat pad weight normalized to body weight; this was accompanied by an increase in glucose compared with wildtype females shown by Student-Newman-Keuls Multiple Comparison test and Student's unpaired t tests. Our studies show that the GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance; the loss of the normal rise of estradiol at postnatal days 15-28 may account for the altered metabolism in the prepubertal female pups.

  4. Activation of corticotropin-releasing factor receptors from the basolateral or central amygdala increases the tonic immobility response in guinea pigs: an innate fear behavior.

    Science.gov (United States)

    Donatti, Alberto Ferreira; Leite-Panissi, Christie Ramos Andrade

    2011-11-20

    The tonic immobility (TI) behavior is an innate response associated with extreme threat situations such as a predator attack. Several studies have provided evidence suggesting an important role for corticotropin-releasing factor (CRF) in the regulation of the endocrine system, defensive behaviors and behavioral responses to stress. TI has been shown to be positively correlated with the basal plasma levels of corticosterone. CRF receptors and neurons that are immunoreactive to CRF are found in many cerebral regions, especially in the amygdaloid complex. Previous reports have demonstrated the involvement of the basolateral amygdaloid (BLA) and central amygdaloid (CeA) nuclei in the TI response. In this study, we evaluated the CRF system of the BLA and the CeA in the modulation of the TI response in guinea pigs. The activation of CRF receptors in the BLA and in the CeA promoted an increase in the TI response. In contrast, the inhibition of these receptors via alpha-helical-CRF(9-41) decreased the duration of the TI response. Moreover, neither the activation nor inhibition of CRF receptors in the BLA or the CeA altered spontaneous motor activity in the open-field test. These data suggest that the activation of the CRF receptors in the BLA or the CeA probably potentiates fear and anxiety, which may be one of the factors that promote an increase in the TI behavior. Therefore, these data support the role of the CRF system in the control of emotional responses, particularly in the modulation of innate fear. Copyright © 2011 Elsevier B.V. All rights reserved.

  5. On the role of subsecond dopamine release in conditioned avoidance

    Directory of Open Access Journals (Sweden)

    Erik B Oleson

    2013-06-01

    Full Text Available Using shock avoidance procedures to study conditioned behavioral responses has a rich history within the field of experimental psychology. Such experiments led to the formulation of the general concept of negative reinforcement and specific theories attempting to explain escape and avoidance behavior, or why animals choose to either terminate or prevent the presentation of an aversive event. For example, the two-factor theory of avoidance holds that cues preceding an aversive event begin to evoke conditioned fear responses, and these conditioned fear responses reinforce the instrumental avoidance response. Current neuroscientific advances are providing new perspectives into this historical literature. Due to its well-established role in reinforcement processes and behavioral control, the mesolimbic dopamine system presented itself as a logical starting point in the search for neural correlates of avoidance and escape behavior. We recently demonstrated that phasic dopamine release events are inhibited by stimuli associated with aversive events but increased by stimuli preceding the successful avoidance of the aversive event. The latter observation is inconsistent with the second component of the two-factor theory of avoidance and; therefore, led us propose a new theoretical explanation of conditioned avoidance: 1 fear is initially conditioned to the warning signal and dopamine computes this fear association as a decrease in release, 2 the warning signal, now capable of producing a negative emotional state, suppresses dopamine release and behavior, 3 over repeated trials the warning signal becomes associated with safety rather than fear; dopaminergic neurons already compute safety as an increase in release and begin to encode the warning signal as the earliest predictor of safety 4 the warning signal now promotes conditioned avoidance via dopaminergic modulation of the brain’s incentive-motivational circuitry.

  6. A study on the behavior and colonization of translocated Greater One-horned Rhinos Rhinoceros unicornis (Mammalia: Perissodactyla: Rhinocerotidae during 90 days from their release at Manas National Park, Assam India

    Directory of Open Access Journals (Sweden)

    Deba Kumar Dutta

    2015-02-01

    Full Text Available Under the Indian Rhino Vision 2020, 18 wild Greater One-horned Rhinos Rhinoceros unicornis were translocated from two rhino bearing areas, Kaziranga National Park and Pobitora Wildlife Sanctuary to Manas National Park within the state of Assam, from 2008 to 2012. Following the release, the rhinos were closely monitored through radio tracking and direct observation to record their colonization pattern and behavioral adaptation to the new environment. Out of the 18 rhinos released at Manas, 16 (89% rhinos dispersed in approximately the same direction from the release sites. The rhinos released from Pobitora Wildlife Sanctuary strayed more when compared to the rhinos from Kaziranga National Park. This paper describes the behavior patterns observed in Manas National Park, which may provide a useful alternative approach for future rhino translocation.

  7. Lasting consequences of traumatic events on behavioral and skeletal parameters in a mouse model for post-traumatic stress disorder (PTSD).

    Science.gov (United States)

    Yu, Hongrun; Watt, Heather; Kesavan, Chandrasekhar; Johnson, Patrick J; Wergedal, Jon E; Mohan, Subburaman

    2012-01-01

    Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health. However, there have been no studies to examine the direct relationship between PTSD and bone. We employed electric shocks in mice to simulate traumatic events that cause PTSD. We also injected the anxiogenic drug FG-7142 prior to electric shocks. Electric shocks created lasting conditioned fear memory in all mice. In young mice, electric shocks elicited not only behavioral response but also skeletal response, and injection of FG-7142 appeared to increase both types of response. For example in behavioral response within the first week, mice shocked alone froze an average of 6.2 sec in 10 sec tests, and mice injected with FG-7142 froze 7.6 sec, both significantly different (PPTSD-like behavior was associated with reduced bone mass acquisition. This is the first study to document evidence that traumatic events induce lasting consequences on both behavior and skeletal growth, and electric shocks coupled with injection of anxiogenic FG-7142 in young mice can be used as a model to study the effect of PTSD-like symptoms on bone development.

  8. Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.

    Science.gov (United States)

    Demuyser, Thomas; Bentea, Eduard; Deneyer, Lauren; Albertini, Giulia; Massie, Ann; Smolders, Ilse

    2016-07-28

    The corticosterone mouse model is widely used in preclinical research towards a better understanding of mechanisms of major depression. One particular administration procedure is the subcutaneous implantation of corticosterone slow-release pellets. In this report we want to provide basic evidence, regarding behavioral changes, neurotransmitter and -modulator levels and some other relevant biomolecules after hypothalamic-pituitary-adrenal-axis distortion. We show that three weeks of corticosterone pellet exposure robustly induces depressive-like but not anxiety-like behavior in mice, accompanied by a significant decrease in hippocampal brain-derived neurotrophic factor levels, at five weeks after the start of treatment. Furthermore there is an overall decrease in plasma corticosterone levels after three weeks of treatment that lasts up until the five weeks' time point. On the other hand, no differences are observed in total monoamine, glutamate or d-serine levels, nor in glucocorticoid receptor expression, in various depression-related brain areas. Altogether this characterization delivers vital information, supplementary to existing literature, regarding the phenotyping of pellet-induced hypothalamic-pituitary-adrenal-axis disruption in mice following three weeks of continuous corticosterone exposure. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

    Directory of Open Access Journals (Sweden)

    Dickenson Anthony H

    2009-02-01

    Full Text Available Abstract Nerve injury-induced expression of the spinal calcium channel alpha-2-delta-1 subunit (Cavα2δ1 has been shown to mediate behavioral hypersensitivity through a yet identified mechanism. We examined if this neuroplasticity modulates behavioral hypersensitivity by regulating spinal glutamatergic neurotransmission in injury-free transgenic mice overexpressing the Cavα2δ1 proteins in neuronal tissues. The transgenic mice exhibited hypersensitivity to mechanical stimulation (allodynia similar to the spinal nerve ligation injury model. Intrathecally delivered antagonists for N-methyl-D-aspartate (NMDA and α-amino-3-hydroxyl-5-methylisoxazole-4-propionic acid (AMPA/kainate receptors, but not for the metabotropic glutamate receptors, caused a dose-dependent allodynia reversal in the transgenic mice without changing the behavioral sensitivity in wild-type mice. This suggests that elevated spinal Cavα2δ1 mediates allodynia through a pathway involving activation of selective glutamate receptors. To determine if this is mediated by enhanced spinal neuronal excitability or pre-synaptic glutamate release in deep-dorsal horn, we examined wide-dynamic-range (WDR neuron excitability with extracellular recording and glutamate-mediated excitatory postsynaptic currents with whole-cell patch recording in deep-dorsal horn of the Cavα2δ1 transgenic mice. Our data indicated that overexpression of Cavα2δ1 in neuronal tissues led to increased frequency, but not amplitude, of miniature excitatory post synaptic currents mediated mainly by AMPA/kainate receptors at physiological membrane potentials, and also by NMDA receptors upon depolarization, without changing the excitability of WDR neurons to high intensity stimulation. Together, these findings support a mechanism of Cavα2δ1-mediated spinal sensitization in which elevated Cavα2δ1 causes increased pre-synaptic glutamate release that leads to reduced excitation thresholds of post-synaptic dorsal

  10. Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

    Science.gov (United States)

    Nguyen, David; Deng, Ping; Matthews, Elizabeth A; Kim, Doo-Sik; Feng, Guoping; Dickenson, Anthony H; Xu, Zao C; Luo, Z David

    2009-01-01

    Nerve injury-induced expression of the spinal calcium channel alpha-2-delta-1 subunit (Cavα2δ1) has been shown to mediate behavioral hypersensitivity through a yet identified mechanism. We examined if this neuroplasticity modulates behavioral hypersensitivity by regulating spinal glutamatergic neurotransmission in injury-free transgenic mice overexpressing the Cavα2δ1 proteins in neuronal tissues. The transgenic mice exhibited hypersensitivity to mechanical stimulation (allodynia) similar to the spinal nerve ligation injury model. Intrathecally delivered antagonists for N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxyl-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptors, but not for the metabotropic glutamate receptors, caused a dose-dependent allodynia reversal in the transgenic mice without changing the behavioral sensitivity in wild-type mice. This suggests that elevated spinal Cavα2δ1 mediates allodynia through a pathway involving activation of selective glutamate receptors. To determine if this is mediated by enhanced spinal neuronal excitability or pre-synaptic glutamate release in deep-dorsal horn, we examined wide-dynamic-range (WDR) neuron excitability with extracellular recording and glutamate-mediated excitatory postsynaptic currents with whole-cell patch recording in deep-dorsal horn of the Cavα2δ1 transgenic mice. Our data indicated that overexpression of Cavα2δ1 in neuronal tissues led to increased frequency, but not amplitude, of miniature excitatory post synaptic currents mediated mainly by AMPA/kainate receptors at physiological membrane potentials, and also by NMDA receptors upon depolarization, without changing the excitability of WDR neurons to high intensity stimulation. Together, these findings support a mechanism of Cavα2δ1-mediated spinal sensitization in which elevated Cavα2δ1 causes increased pre-synaptic glutamate release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous

  11. Assessment of the regional economic impacts of catastrophic events: CGE analysis of resource loss and behavioral effects of an RDD attack scenario.

    Science.gov (United States)

    Giesecke, J A; Burns, W J; Barrett, A; Bayrak, E; Rose, A; Slovic, P; Suher, M

    2012-04-01

    We investigate the regional economic consequences of a hypothetical catastrophic event-attack via radiological dispersal device (RDD)-centered on the downtown Los Angeles area. We distinguish two routes via which such an event might affect regional economic activity: (i) reduction in effective resource supply (the resource loss effect) and (ii) shifts in the perceptions of economic agents (the behavioral effect). The resource loss effect relates to the physical destructiveness of the event, while the behavioral effect relates to changes in fear and risk perception. Both affect the size of the regional economy. RDD detonation causes little capital damage and few casualties, but generates substantial short-run resource loss via business interruption. Changes in fear and risk perception increase the supply cost of resources to the affected region, while simultaneously reducing demand for goods produced in the region. We use results from a nationwide survey, tailored to our RDD scenario, to inform our model values for behavioral effects. Survey results, supplemented by findings from previous research on stigmatized asset values, suggest that in the region affected by the RDD, households may require higher wages, investors may require higher returns, and customers may require price discounts. We show that because behavioral effects may have lingering long-term deleterious impacts on both the supply-cost of resources to a region and willingness to pay for regional output, they can generate changes in regional gross domestic product (GDP) much greater than those generated by resource loss effects. Implications for policies that have the potential to mitigate these effects are discussed. © 2011 Society for Risk Analysis.

  12. A poly(glycerol sebacate)-coated mesoporous bioactive glass scaffold with adjustable mechanical strength, degradation rate, controlled-release and cell behavior for bone tissue engineering.

    Science.gov (United States)

    Lin, Dan; Yang, Kai; Tang, Wei; Liu, Yutong; Yuan, Yuan; Liu, Changsheng

    2015-07-01

    Various requirements in the field of tissue engineering have motivated the development of three-dimensional scaffold with adjustable physicochemical properties and biological functions. A series of multiparameter-adjustable mesoporous bioactive glass (MBG) scaffolds with uncrosslinked poly(glycerol sebacate) (PGS) coating was prepared in this article. MBG scaffold was prepared by a modified F127/PU co-templating process and then PGS was coated by a simple adsorption and lyophilization process. Through controlling macropore parameters and PGS coating amount, the mechanical strength, degradation rate, controlled-release and cell behavior of the composite scaffold could be modulated in a wide range. PGS coating successfully endowed MBG scaffold with improved toughness and adjustable mechanical strength covering the bearing range of trabecular bone (2-12MPa). Multilevel degradation rate of the scaffold and controlled-release rate of protein from mesopore could be achieved, with little impact on the protein activity owing to an "ultralow-solvent" coating and "nano-cavity entrapment" immobilization method. In vitro studies indicated that PGS coating promoted cell attachment and proliferation in a dose-dependent manner, without affecting the osteogenic induction capacity of MBG substrate. These results first provide strong evidence that uncrosslinked PGS might also yield extraordinary achievements in traditional MBG scaffold. With the multiparameter adjustability, the composite MBG/PGS scaffolds would have a hopeful prospect in bone tissue engineering. The design considerations and coating method of this study can also be extended to other ceramic-based artificial scaffolds and are expected to provide new thoughts on development of future tissue engineering materials. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Long term behavior of radioactive plume of TEPCO FNPP1 released 134Cs and 137Cs in the North Pacific Ocean through the end of 2014

    Science.gov (United States)

    Aoyama, Michio; Tsumune, Daisuke; Tsubono, Takaki; Hamajima, Yasunori; Kumamoto, Yuichiro

    2015-04-01

    134Cs and 137Cs, hereafter radiocaesium, were released to the North Pacific Ocean by two major likely pathways, direct discharge from the Fukushima NPP1 accident site and atmospheric deposition off Honshu Islands of Japan, east and northeast of the site. High density observations of 134Cs and 137Cs in the surface water were carried out by 17 cruises of cargo ships and several research vessel cruises since March 2011 till March 2012. Thereafter we and our collaborators continue to collect seawater samples in 2013 and 2014 in the North Pacific Ocean. We also conduct to measure radiocaesium in coastal waters at Tomioka and Hasaki, Japan through the end of 2014. TEPCO and Japanese government also continue to monitor radiocaesium in seawaters close to the site. In this presentation, we present long term behavior of TEPCO FNPP1 released radiocaesium in the coastal region and the North Pacific Ocean based on the observations and model simulations during the period from just after the accident to summer in 2014. In the coastal region very close to TEPCO FNPP1 site, the data show peak ocean discharges in early April 2011, one month after the earthquake and a factor of 1000 decrease in the month following. The 137Cs activity through the end of September 2014 remain higher than expected, ca. 1000 Bq m-3, implying continued releases from the reactors. Since directly discharged radiocaesium were transported dominantly southward along the coastline of northeastern Honshu, the 137Cs activities in coastal seawater collected at Tomioka and Hasaki were still one or two order of magnitude higher, several to 100 Bq m-3, rather than pre-Fukushima level in summer 2014. In the North Pacific Ocean main body of radiocaesium surface plume of which activity exceed 10 Bq m-3 had been travelling along 40 °N, and reached International Date Line on March 2012 one year after the accident. A feature was that the radiocaesium plume was confined along 40 °N when the plume reached International

  14. Dynamical behavior of a rumor transmission model with Holling-type II functional response in emergency event

    Science.gov (United States)

    Huo, Liang'an; Jiang, Jiehui; Gong, Sixing; He, Bing

    2016-05-01

    Rumor transmission has become an important issue in emergency event. In this paper, a rumor transmission model with Holling-type II functional response was proposed, which provides excellent explanations of the scientific knowledge effect with rumor spreading. By a global analysis of the model and studying the stability of the rumor-free equilibrium and the rumor-endemic equilibrium, we found that the number of infective individuals equal to zero or positive integer as time went on. A numerical simulation is carried out to illustrate the feasibility of our main results. The results will provide the theoretical support to rumor control in emergency event and also provide decision makers references for the public opinions management.

  15. Deciphering storm-event runoff behavior in a coastal plain watershed using chemical and physical hydrograph separation techniques

    Science.gov (United States)

    Timothy Callahan; Austin E. Morrison

    2016-01-01

    Interpreting storm-event runoff in coastal plain watersheds is challenging because of the space- and time-variable nature of different sources that contribute to stream flow. These flow vectors and the magnitude of water flux is dependent on the pre-storm soil moisture (as estimated from depth to water table) in the lower coastal plain (LCP) region.

  16. The 5-HTTLPR polymorphism moderates the effect of stressful life events on drinking behavior in college students of African descent.

    Science.gov (United States)

    Kranzler, Henry R; Scott, Denise; Tennen, Howard; Feinn, Richard; Williams, Carla; Armeli, Stephen; Taylor, Robert E; Briggs-Gowan, Margaret J; Covault, Jonathan

    2012-07-01

    Covault et al. [Covault et al. (2007); Biol Psychiatry 61(5): 609-616] reported that the common functional polymorphism, 5-HTTLPR, in the serotonin transporter gene moderated the association between past-year stressful events and daily reports of drinking in a sample of European-American (EA) college students. We examined this effect in college students of African descent. Students recruited at a Historically Black University (n = 564) completed web-based measures of past-year stressful life experiences and daily reports of drinking and heavy drinking over a 30-day period. Participants were genotyped for the tri-allelic 5-HTTLPR polymorphism and dichotomized as low-activity S' allele carriers or high-activity L' homozygotes. Generalized linear models were used to examine the effects of life stress, genotype, and their interaction on the two drinking measures. In students who completed 15 or more daily surveys (n = 393), there was a significant interaction of past-year stressful events, 5-HTTLPR genotype, and gender on the number of drinking days (P = 0.002). Similar findings were obtained in relation to heavy drinking days (P = 0.007). Men showed a main effect of past-year stressful events on both drinking outcomes (P's life stressors on the frequency of drinking and heavy drinking days (P's stressful events were associated with more frequent drinking and heavy drinking, an effect that was moderated by the 5-HTTLPR polymorphism. However, in contrast to the findings in EA students, in the current sample, 5-HTTLPR moderated the association only among women. Copyright © 2012 Wiley Periodicals, Inc.

  17. Basic Auditory Processing Deficits in Dyslexia: Systematic Review of the Behavioral and Event-Related Potential/Field Evidence

    Science.gov (United States)

    Hämäläinen, Jarmo A.; Salminen, Hanne K.; Leppänen, Paavo H. T.

    2013-01-01

    A review of research that uses behavioral, electroencephalographic, and/or magnetoencephalographic methods to investigate auditory processing deficits in individuals with dyslexia is presented. Findings show that measures of frequency, rise time, and duration discrimination as well as amplitude modulation and frequency modulation detection were…

  18. Event-Specific Analyses of Poly-Drug Abuse and Concomitant Risk Behavior in a College Bar District in Florida

    Science.gov (United States)

    Thombs, Dennis L.; O'Mara, Ryan; Dodd, Virginia J.; Merves, Michele L.; Weiler, Robert M.; Goldberger, Bruce A.; Pokorny, Steven B.; Moore, Christine; Reingle, Jennifer; Gullet, Sara E.

    2009-01-01

    Objective: The authors describe the epidemiology of risk behavior associated with poly-drug use in a college bar district of a large campus community. Participants: A total of 469 bar patrons participated in the study. Methods: The authors used self-report data and biological measures collected from patrons outside bars in July and August of…

  19. The impact of near-miss events on betting behavior: An examination of casino rapid roulette play

    Directory of Open Access Journals (Sweden)

    James A. Sundali

    2012-11-01

    Full Text Available We examine how almost winning in roulette affects subsequent betting behavior. Our main finding is heterogeneity in gambler behavior with some gamblers less likely to bet on numbers that were near misses on the prior spin and other gamblers more likely to bet on near miss numbers. Using a unique data set from the game rapid roulette, we model the likelihood of a gambler betting on a near miss number while controlling for the favorite number bias and the likelihood of a number being a near miss. We also find no evidence that near misses in roulette leads to gamblers extending the time spent gambling or to the placing of more bets.

  20. Preparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules

    KAUST Repository

    Song, Xiaowan

    2016-05-28

    Poly(ethylene glycol) (PEG), a polymer with excellent biocompatibility, was widely used to form nanoparticles for drug delivery applications. In this paper, based on PEG, a series of pH-sensitive amphiphilic block star polymers of poly(ethylene glycol)-block-poly(ethoxy ethyl glycidyl ether) (PEG-b-PEEGE) with different hydrophobic length were synthesized by living anionic ring-opening polymerization method. The products were characterized using 1H NMR and gel permeation chromatography. These copolymers could self-assemble in aqueous solution to form micellar structure with controlled morphologies. Transmission electron microscopy showed that the nanoparticles are spherical or rodlike with different hydrophilic mass fractions. The pH response of polymeric aggregates from PEG-b-PEEGE was detected by fluorescence probe technique at different pH. A pH-dependent release behavior was observed and pH-responsiveness of PEG-b-PEEGE was affected by the hydrophobic block length. These results demonstrated that star-shaped polymers (PEG-b-PEEGE) are attractive candidates as anticancer drug delivery carriers. © 2016 Springer-Verlag Berlin Heidelberg

  1. Evaluation of the behavior and movement of adult summer steelhead in the lower Cowlitz River, Washington, following collection and release, 2013-2014

    Science.gov (United States)

    Kock, Tobias J.; Liedtke, Theresa L.; Ekstrom, Brian K.; Gleizes, Chris; Dammers, Wolf

    2014-01-01

    Summer steelhead (Oncorhynchus mykiss) produced by a hatchery on the lower Cowlitz River, Washington, support a popular sport fishery during June–September each year. Many of these fish return to the Cowlitz Salmon Hatchery and are held until they are spawned in December. In the past, fishery managers have released some of the steelhead that return to the hatchery at downstream release sites (hereafter referred to as “recycled steelhead”) to increase angling opportunity. The recycling of summer steelhead is a potential use of hatchery fish that can benefit anglers in the lower Cowlitz River, provided these fish are harvested or return to the hatchery. However, recycled steelhead that are not removed from the river could compete against or spawn with wild winter steelhead, which would be a negative consequence of recycling. The Washington Department of Fish and Wildlife (WDFW) conducted an evaluation during 1998 and recycled 632 summer steelhead. They determined that 55 percent of the recycled steelhead returned to the hatchery and 15 percent of the fish were harvested by anglers. The remaining 30 percent of recycled fish were not known to have been removed from the river. Recycling has not occurred in recent years because definitive studies have not been conducted to determine the fate of the fish that remain in the lower Cowlitz River after being recycled. The U.S. Geological Survey and WDFW conducted a 2-year study during 2012–2014 to quantify recycled steelhead that (1) returned to the hatchery, (2) were captured by anglers, or (3) remained in the river. All recycled steelhead were marked with a Floy® tag and opercle punch, and 20 percent of the recycled fish were radio-tagged to determine post-release behavior and movement patterns, and to describe locations of tagged fish that remained in the river during the spawning period. During 2012–2013, we recycled 549 steelhead and determined that 50 percent of the fish returned to the hatchery, 18 percent

  2. Sun protection behavior and knowledge of patients attending laser clinic to prevent adverse events of laser: A Cross-sectional, Single Center, Tertiary Care Study.

    Science.gov (United States)

    Tempark, Therdpong; Lueangarun, Suparuj; Chatproedprai, Susheera; Panchaprateep, Ratchathorn; Pongprutthipan, Marisa; Wananukul, Siriwan

    2018-06-08

    Limited data of sun protection knowledge in laser treatment patients exists therefore, preventative information should be provided by dermatologists to minimize harmful effects. To assess sun protection knowledge-behavior and knowledge to prevent adverse events from laser therapy among patients who visited a laser clinic at a tertiary university hospital in Bangkok, Thailand. This is a self-reported questionnaire, cross-sectional survey. All participants from the Laser Clinic in KCMH were recruited into the study. A Total of 385 patients were enrolled into the study; 80.5% female participants. Patients who never received laser treatment significantly lacked proper sun protection knowledge to prevent adverse events of lasers when compared to those who previous received laser treatments regarding the application of sunscreen after laser treatment (56.6% vs 17.4%, p protection in the post laser area (41.9% vs 20.4%, p knowledge of sun protection to prevent adverse events were significantly different among the group of educational levels and previous history of laser treatment. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  3. Towards Multimodal Error Management:Experimental Evaluation of User Strategies in Event of Faulty Application Behavior in Automotive Environments

    Directory of Open Access Journals (Sweden)

    Gregor McGlaun

    2004-10-01

    Full Text Available In this work, we present the results of a study analyzing the reactions of subjects on simulated errors of a dedicated in-car interface for controlling infotainment and communication services. The test persons could operate the system, using different input modalities, such as natural or command speech as well as head and hand gestures, or classical tactile paradigms. In various situational contexts, we scrutinized the interaction patterns the test participants applied to overcome different operation tasks. Moreover, we evaluated individual user behavior concerning modality transitions and individual fallback strategies in case of system errors. Two different error types (Hidden System Errors and Apparent System Errors were provoked. As a result, we found out that initially, i.e. with the system working properly, most users prefer tactile or speech interaction. In case of Hidden System Errors, mostly changes from speech to tactile interaction and vice versa occurred. Concerning Apparent System Errors, 87% of the subjects automatically interrupted or cancelled their input procedure. 73% of all test persons who continued interaction, when the reason for the faulty system behavior was gone, strictly kept the selected modality. Regarding the given input vocabulary, none of the subjects selected head or hand gesture input as the leading fallback modality.

  4. Behavioral activation for smoking cessation and mood management following a cardiac event: results of a pilot randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Andrew M. Busch

    2017-04-01

    Full Text Available Abstract Background Smoking cessation following hospitalization for Acute Coronary Syndrome (ACS significantly reduces subsequent mortality. Depressed mood is a major barrier to cessation post-ACS. Although existing counseling treatments address smoking and depression independently in ACS patients, no integrated treatment addresses both. We developed an integrated treatment combining gold standard cessation counseling with behavioral activation-based mood management; Behavioral Activation Treatment for Cardiac Smokers (BAT-CS. The purpose of this pilot randomized controlled trial was to test feasibility, acceptability, and preliminary efficacy of BAT-CS vs. Standard of Care (SC. Methods Participants were recruited during hospitalization for ACS and were randomly assigned to BAT-CS or SC. The nicotine patch was offered in both conditions. Smoking, mood, and stress outcomes were collected at end-of-treatment and 24-week follow-up. Results Fifty-nine participants (28 BAT-CS, 31 SC were recruited over 42 weeks, and assessment completion was above 80% in both conditions. Treatment acceptability and fidelity were high. At 24 week follow-up adjusted odds ratios favoring BAT-CS were 1.27 (95% CI: 0.41–3.93 for 7-day point prevalence abstinence and 1.27 (95% CI: 0.42–3.82 for continuous abstinence. Time to first smoking lapse was significantly longer in BAT-CS (62.4 vs. 31.8 days, p = 0.03. At 24-weeks, effect sizes for mood and stress outcomes ranged from η2 partial of.07–.11, with significant between treatment effects for positive affect, negative affect, and stress. Conclusions The design of this study proved feasible and acceptable. Results provide preliminary evidence that combining behavioral activation with standard smoking cessation counseling could be efficacious for this high risk population. A larger trial with longer follow-up is warranted. Trial registration NCT01964898 . First received by clinicaltrials.gov October 15, 2013.

  5. Probing intra-cellular drug release event using activatable (OFF/ON) CdS:Mn/ZnS quantum dots (Qdots): spectroscopic studies to investigate interaction of Qdots with quencher

    Science.gov (United States)

    Tharkur, Jeremy; Teblum, Andrew; Basumallick, Srijita; Shah, Rikhav; Cantarero, Karishma; Maity, Niharika; Rifai, Sara; Doshi, Mona; Gesquiere, Andre J.; Santra, Swadeshmukul

    2013-02-01

    In recent years, activatable Quantum Dots (AQdots) are gaining popularity in a number of chemical and biological sensing applications. A basic design of AQdot probes involves a suitable quencher which is capable of altering optical properties of the Qdots. In our previous studies we have shown that CdS:Mn/ZnS fluorescence can be effectively quenched using small molecule quenchers (such as dopamine, chemotherapeutic drug) as well as iron oxide nanoparticle via electron/energy transfer process. We have also shown that the quenched Qdot fluorescence can be restored when the Qdots are separated from the quencher. Using Qdot based activatable probes, we detected intracellular drug release event. Qdot fluorescence was restored upon interaction with the intracellular glutathione (GSH). In this paper, we report a GSH induced quenching of water-soluble N-Acetyl Cysteine (NAC) surface-conjugated Cds:Mn/ZnS Qdots. Quenching of NAC-Qdots was due to aggregation of Qdots in solution. This aggregation induced fluorescence quenching phenomenon resembles with the self-quenching phenomenon of traditional organic fluorescence dyes at high concentrations. UV-VIS and fluorescence emission spectroscopy data support the interaction and binding of GSH with the NAC-Qdots. Increase in particle size due to GSH induced aggregation of NAC-Qdots was confirmed by the Dynamic Light Scattering (DLS) data.

  6. Work plan: transient release from LMFBR fuel

    International Nuclear Information System (INIS)

    Kress, T.S.; Parker, G.W.; Fontana, M.H.

    1975-09-01

    The proposed LMFBR Transient Release Program at ORNL is designed to investigate, by means of ex-reactor experiments and analytical modeling, the release and transport of fuel, fission products, and transuranic elements from fast reactor cores in the event of certain hypothetical accidents. It is desired to experimentally produce energy depositions that are characteristic of severe hypothetical reactor transients by the application of direct electrical current to mixed-oxide fuels under sodium. The experimental program includes tests with and without sodium, investigations of alternative methods of generating fuel and sodium aerosols, the use of UO 2 as a fuel simulant, additions of tracers as fission product simulants, effects of radiation, and under-water and under-sodium efforts to study the behavior of the vapor bubble itself. Analytical modeling will accompany all phases of the program, and the data will be correlated with models developed. 21 references. (auth)

  7. They all do it, will you? Event-related potential evidence of herding behavior in online peer-to-peer lending.

    Science.gov (United States)

    Yu, Haihong; Dan, MengHan; Ma, Qingguo; Jin, Jia

    2018-05-14

    As herding is a typical characteristic of human behavior, many researchers have found the existence of herding behavior in online peer-to-peer lending through empirical surveys. However, the underlying neural basis of this phenomenon is still unclear. In the current study, we studied the neural activities of herding at decision-making stage and feedback stage using event-related potentials (ERPs). Our results showed that at decision-making stage, larger error related negativity (ERN) amplitude was induced under low-proportion conditions than that of high-proportion conditions. Meanwhile, during feedback stage, negative feedback elicited larger feedback related negativity (FRN) amplitude than that of positive feedback under low-proportion conditions, however, there was no significant FRN difference under high-proportion conditions. The current study suggests that herding behavior in online peer-to-peer lending is related to individual's risk perception and is possible to avoid negative emotions brought by failed investments. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. The behavior of crude oil spot and futures prices around OPEC and SPR announcements: An event study perspective

    International Nuclear Information System (INIS)

    Demirer, Riza; Kutan, Ali M.

    2010-01-01

    This paper examines the informational efficiency of crude oil spot and futures markets with respect to OPEC conference and U.S. Strategic Petroleum Reserve (SPR) announcements. We employ the event study methodology to examine the abnormal returns in crude oil spot and futures markets around OPEC conference and SPR announcement dates between 1983 and 2008. Our findings regarding OPEC announcements indicate an asymmetry in that only OPEC production cut announcements yield a statistically significant impact with the impact diminishing for longer maturities. We also find that the persistence of returns following OPEC production cut announcements creates substantial excess returns to investors who take long positions on the day following the end of OPEC conferences. In the case of SPR announcements, we find that the government's use of this program initiates a short-run market reaction following the announcement date. Furthermore, our tests of cumulative abnormal returns suggest that the market reacts efficiently to SPR announcements providing support for the use of the strategic reserves as a tool to stabilize the oil market. Our findings have significant policy implications for investors and are useful in designing effective energy policy strategies.

  9. The procrastinators want it now: Behavioral and event-related potential evidence of the procrastination of intertemporal choices.

    Science.gov (United States)

    Wu, Haiyan; Gui, Danyang; Lin, Wenzheng; Gu, Ruolei; Zhu, Xiangru; Liu, Xun

    2016-08-01

    Much past research has focused on the correlation between procrastination and personality traits (e.g., impulsivity). According to the temporal motivation theory, procrastinators are impulsive and sensitive to delays in time. However, there is still a lack of direct evidence of the tendency of procrastinators to prefer immediate over future rewards. To investigate this question, we recorded event-related potentials (ERPs) in the brain while participants performed an intertemporal choice task involving both time delay and reward processing. The participants were assigned to a high procrastination group and a low procrastination group according to their scores on self-report measures. We found that high procrastination participants preferred immediate rewards compared to future ones whereas low procrastination participants did not. High procrastinators also exhibited a larger and delayed P2 component, indicating delay time processing and abnormal reward processing. No significant effect associated with procrastination was found on the P300 component. Taken together, these findings suggest that high procrastinators are more impulsive and encode the information of delay time more slowly but with a higher level of motivation-driven attention. The current study substantiates higher impulsivity in procrastination and verifies that a difference exists in the sensitivity to time delay between high and low procrastinators. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Integration of sensory information precedes the sensation of vection: a combined behavioral and event-related brain potential (ERP) study.

    Science.gov (United States)

    Keshavarz, Behrang; Berti, Stefan

    2014-02-01

    Illusory self-motion (known as vection) describes the sensation of ego-motion in the absence of physical movement. Vection typically occurs in stationary observers being exposed to visual information that suggest self-motion (e.g. simulators, virtual reality). In the present study, we tested whether sensory integration of visual information triggers vection: participants (N=13) perceived patterns of moving altered black-and-white vertical stripes on a screen that was divided into a central and a surrounding peripheral visual field. In both fields the pattern was either moving or stationary, resulting in four combinations of central and peripheral motions: (1) central and peripheral stripes moved into the same direction, (2) central and peripheral stripes moved in opposite directions, or (3) either the central or (4) the peripheral stripes were stable while the other stripes were in motion. This stimulation induced vection: Results showed significantly higher vection ratings when the stationary center of the pattern was surrounded by a moving periphery. Event-related potentials mirrored this finding: The occipital N2 was largest with stationary central and moving peripheral stripes. Our findings suggest that sensory integration of peripheral and central visual information triggers the perception of vection. Furthermore, we found evidence that neural processes precede the subjective perception of vection strength prior to the actual onset of vection. We will discuss our findings with respect to the role of stimulus eccentricity, stimulus' depth, and neural correlates involved during the genesis of vection. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Exploring the switching of the focus of attention within working memory: A combined event-related potential and behavioral study.

    Science.gov (United States)

    Frenken, Marius; Berti, Stefan

    2018-04-01

    Working memory enables humans to maintain selected information for cognitive processes and ensures instant access to the memorized contents. Theories suggest that switching the focus of attention between items within working memory realizes the access. This is reflected in object-switching costs in response times when the item for the task processing is to be changed. Another correlate of attentional allocation in working memory is the P3a-component of the human event-related potential. The aim of this study was to demonstrate that switching of attention within working memory is a separable processing step. Participants completed a cued memory-updating task in which they were instructed to update one memory item at a time out of a memory list of four digits by applying a mathematical operation indicated by a target sign. The hypotheses predicted (1) prolonged updating times in switch (different item compared to previous trial) versus repetition trials (same item), (2) an influence of cues (valid/neutral) presented before the mathematical target on switching costs, and (3) that the P3a-component is more pronounced in the cue-target interval in the valid cue condition and more pronounced in the post-target interval in the neutral cue condition. A student's t-test verified the first hypothesis, repeated-measurement analyses of variance demonstrated that hypotheses 2 and 3 should be rejected. Results suggest that switching of attention within working memory could not be separated from further processing steps and retro-cue benefits are not due to a head start of retrieval as well as that switch costs represent internal processes. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. The role of REM sleep in the processing of emotional memories: evidence from behavior and event-related potentials.

    Science.gov (United States)

    Groch, S; Wilhelm, I; Diekelmann, S; Born, J

    2013-01-01

    Emotional memories are vividly remembered for the long-term. Rapid eye movement (REM) sleep has been repeatedly proposed to support the superior retention of emotional memories. However, its exact contribution and, specifically, whether its effect is mainly on the consolidation of the contents or the processing of the affective component of emotional memories is not clear. Here, we investigated the effects of sleep rich in slow wave sleep (SWS) or REM sleep on the consolidation of emotional pictures and the accompanying changes in affective tone, using event-related potentials (ERPs) together with subjective ratings of valence and arousal. Sixteen healthy, young men learned 50 negative and 50 neutral pictures before 3-h retention sleep intervals that were filled with either SWS-rich early or REM sleep-rich late nocturnal sleep. In accordance with our hypothesis, recognition was better for emotional pictures than neutral pictures after REM compared to SWS-rich sleep. This emotional enhancement after REM-rich sleep expressed itself in an increased late positive potential of the ERP over the frontal cortex 300-500 ms after stimulus onset for correctly classified old emotional pictures compared with new emotional and neutral pictures. Valence and arousal ratings of emotional pictures were not differentially affected by REM or SWS-rich sleep after learning. Our results corroborate that REM sleep contributes to the consolidation of emotional contents in memory, but suggest that the affective tone is preserved rather than reduced by the processing of emotional memories during REM sleep. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. Ontogenic events and swimming behavior of larvae of the characid fish Salminus brasiliensis (Cuvier (Characiformes, Characidae under laboratory conditions

    Directory of Open Access Journals (Sweden)

    José Enemir dos Santos

    2002-03-01

    Full Text Available The larval ontogeny and swimming behavior of the characid fish Salminus brasiliensis (Cuvier, 1816 were studied under experimental laboratory conditions, from hatching to yolk absorption. At day 1, the larvae were transparent, with sparse dendrite chromatophores and a well-developed adhesive organ on the head. The retinal epithelial cells were initiating pigmentation. The branchial arches were at the initial phase of differentiation. The larvae were able to perform only vertical displacements and, when resting on the tank bottom, remained in lateral decumbency, in groups of 3 to 15 larvae. On day 2, the mouth was open, with conical teeth, and the digestive tube presented lumen and folded mucosa. The gaseous bladder and pectoral fins also were in differentiation. The larvae performed vertical and horizontal movements, adhered to the water surface by means of the adhesive organ or formed groups of three to six on the tank bottom. On day 3, the adhesive organ turned dorsal, the retina was pigmented, the digestive tube mucosa showed goblet cells, and the yolk sac exhausted. The larvae were now scattering in the water column forming no groups on the bottom.

  14. Behaviorism

    Science.gov (United States)

    Moore, J.

    2011-01-01

    Early forms of psychology assumed that mental life was the appropriate subject matter for psychology, and introspection was an appropriate method to engage that subject matter. In 1913, John B. Watson proposed an alternative: classical S-R behaviorism. According to Watson, behavior was a subject matter in its own right, to be studied by the…

  15. Transcranial Direct Current Stimulation in Patients with Prolonged Disorders of Consciousness: Combined Behavioral and Event-Related Potential Evidence

    Directory of Open Access Journals (Sweden)

    Ye Zhang

    2017-11-01

    Full Text Available BackgroundThe electrophysiological evidence supporting the therapeutic efficacy of multiple transcranial direct current stimulation (tDCS sessions on consciousness improvement in patients with prolonged disorders of consciousness (DOCs has not been firmly established.ObjectivesTo assess the effects of repeated tDCS in patients with prolonged DOCs by Coma Recovery Scale-Revised (CRS-R score and event-related potential (ERP.MethodUsing a sham-controlled randomized double-blind design, 26 patients were randomly assigned to either a real [five vegetative state (VS and eight minimally conscious state (MCS patients] or sham (six VS and seven MCS patients stimulation group. The patients in the real stimulation group underwent 20 anodal tDCS sessions of the left dorsolateral prefrontal cortex (DLPFC over 10 consecutive working days. The CRS-R score and P300 amplitude and latency in a hierarchical cognitive assessment were recorded to evaluate the consciousness level before tDCS and immediately after the 20 sessions.ResultsThe intra-group CRS-R analysis revealed a clinically significant improvement in the MCS patients in the real stimulation group. The inter-group CRS-R analysis showed a significant difference in CRS-R between VS and MCS patients at baseline in both the real and sham stimulation groups. The intra-group ERP analysis revealed a significant increase in P300 amplitude after tDCS in the MCS patients in the real stimulation group, but no significant differences in P300 latency. For the inter-group ERP analysis, we observed significant differences regarding the presence of P300 at baseline between the VS and MCS patients in both groups.ConclusionThe repeated anodal tDCS of the left DLPFC could produce clinically significant improvements in MCS patients. The observed tDCS-related consciousness improvements might be related to improvements in attention resource allocation (reflected by the P300 amplitude. The findings support the use of tDCS in

  16. Gas Release Behavior of Cu-TiH2 Composite Powder and Its Application as a Blowing Agent to Fabricate Aluminum Foams with Low Porosity and Small Pore Size

    Science.gov (United States)

    Cheng, Ying; Li, Yanxiang; Chen, Xiang; Liu, Zhiyong; Zhou, Xu; Wang, Ningzhen

    2018-03-01

    Compared to traditional pore structure with high porosity (≥ 80 pct) and large pore size (≥ 3 mm), aluminum foams with low porosity (60 to 70 pct) and small pore size (≤ 2 mm) possess higher compressive property and formability. In order to achieve the goal of reducing pore size, Cu-TiH2 composite powder prepared by ball milling preoxidized TiH2 with Cu powder was used as a blowing agent. Its gas release behavior was characterized by thermogravimetric analysis and differential scanning calorimetry. The results show that the ball milling treatment can advance the gas release process and slow the gas release rate at the same time. All these changes are favorable to the reduction of porosity and pore size. Such Cu-TiH2 composite powder provides an alternative way to fabricate aluminum foams with low porosity and small pore size.

  17. Gas Release Behavior of Cu-TiH2 Composite Powder and Its Application as a Blowing Agent to Fabricate Aluminum Foams with Low Porosity and Small Pore Size

    Science.gov (United States)

    Cheng, Ying; Li, Yanxiang; Chen, Xiang; Liu, Zhiyong; Zhou, Xu; Wang, Ningzhen

    2018-06-01

    Compared to traditional pore structure with high porosity (≥ 80 pct) and large pore size (≥ 3 mm), aluminum foams with low porosity (60 to 70 pct) and small pore size (≤ 2 mm) possess higher compressive property and formability. In order to achieve the goal of reducing pore size, Cu-TiH2 composite powder prepared by ball milling preoxidized TiH2 with Cu powder was used as a blowing agent. Its gas release behavior was characterized by thermogravimetric analysis and differential scanning calorimetry. The results show that the ball milling treatment can advance the gas release process and slow the gas release rate at the same time. All these changes are favorable to the reduction of porosity and pore size. Such Cu-TiH2 composite powder provides an alternative way to fabricate aluminum foams with low porosity and small pore size.

  18. Regulating Drug Release Behavior and Kinetics from Matrix Tablets Based on Fine Particle-Sized Ethyl Cellulose Ether Derivatives: An In Vitro and In Vivo Evaluation

    Directory of Open Access Journals (Sweden)

    Kifayat Ullah Shah

    2012-01-01

    Full Text Available The design and fabrication of sustained/controlled release dosage forms, employing new excipients capable of extending/controlling the release of drugs from the dosage forms over prolonged periods, has worked well in achieving optimally enhanced therapeutic levels of the drugs. In this sense, the objective of this study was to investigate the suitability of selected cellulose ether derivatives for use in direct compression (DC and as efficient drug release controlling agents. Controlled release matrix tablets of ciprofloxacin were prepared at different drug-to-polymer (D : P ratios by direct compression using a fine particle sized ethylcellulose ether derivative (ETHOCEL Standard Premium 7FP as rate controlling polymer. The tablets obtained were evaluated for various physico-chemical characteristics and in-vitro drug release studies were conducted in phosphate buffer (pH 7.4 using PharmaTest dissolution apparatus at constant temperature of 37∘C±0.1. Similarity factor 2 was employed to the release profiles of test formulations and were compared with marketed ciprofloxacin conventional tablets. Drug release mechanism and the kinetics involved were investigated by fitting the release profile data to various kinetic models. It was found that with increasing the proportion of ethylcellulose ether derivative in the matrix, the drug release was significantly extended up to 24 hours. The tablets exhibited zero order or nearly zero order drug transport mechanism. In vivo drug release performance of the developed controlled release tablets and reference conventional tablets containing ciprofloxacin were determined in rabbit serum according to randomized two-way crossover study design using High Performance Liquid Chromatography. Several bioavailability parameters of both the test tablets and conventional tablets including max, max and AUC0- were compared which showed an optimized max and max (<0.05. A good correlation was obtained between in vitro

  19. Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.

    Directory of Open Access Journals (Sweden)

    Devki D Sukhtankar

    Full Text Available Pruritus (itch is a severe side effect associated with the use of drugs as well as hepatic and hematological disorders. Previous studies in rodents suggest that bombesin receptor subtypes i.e. receptors for gastrin-releasing peptide (GRPr and neuromedin B (NMBr differentially regulate itch scratching. However, to what degree spinal GRPr and NMBr regulate scratching evoked by intrathecally administered bombesin-related peptides is not known. The first aim of this study was to pharmacologically compare the dose-response curves for scratching induced by intrathecally administered bombesin-related peptides versus morphine, which is known to elicit itch in humans. The second aim was to determine if spinal GRPr and NMBr selectively or generally mediate scratching behavior. Mice received intrathecal injection of bombesin (0.01-0.3 nmol, GRP (0.01-0.3 nmol, NMB (0.1-1 nmol or morphine (0.3-3 nmol and were observed for one hour for scratching activity. Bombesin elicited most profound scratching over one hour followed by GRP and NMB, whereas morphine failed to evoke scratching response indicating the insensitivity of mouse models to intrathecal opioid-induced itch. Intrathecal pretreatment with GRPr antagonist RC-3095 (0.03-0.1 nmol produced a parallel rightward shift in the dose response curve of GRP-induced scratching but not NMB-induced scratching. Similarly, PD168368 (1-3 nmol only attenuated NMB but not GRP-induced scratching. Individual or co-administration of RC-3095 and PD168368 failed to alter bombesin-evoked scratching. A higher dose of RC-3095 (0.3 nmol generally suppressed scratching induced by all three peptides but also compromised motor function in the rotarod test. Together, these data indicate that spinal GRPr and NMBr independently drive itch neurotransmission in mice and may not mediate bombesin-induced scratching. GRPr antagonists at functionally receptor-selective doses only block spinal GRP-elicited scratching but the suppression of

  20. Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies

    OpenAIRE

    Jaipal, A.; Pandey, M.M.; Charde, S.Y.; Raut, P.P.; Prasanth, K.V.; Prasad, R.G.

    2015-01-01

    Delivery of orally compromised therapeutic drug molecules to the systemic circulation via buccal route has gained a significant interest in recent past. Bioadhesive polymers play a major role in designing such buccal dosage forms, as they help in adhesion of designed delivery system to mucosal membrane and also prolong release of drug from delivery system. In the present study, HPMC (release retarding polymer) and mannitol (diluent and pore former) were used to prepare bioadhesive and control...

  1. Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies.

    Science.gov (United States)

    Jaipal, A; Pandey, M M; Charde, S Y; Raut, P P; Prasanth, K V; Prasad, R G

    2015-07-01

    Delivery of orally compromised therapeutic drug molecules to the systemic circulation via buccal route has gained a significant interest in recent past. Bioadhesive polymers play a major role in designing such buccal dosage forms, as they help in adhesion of designed delivery system to mucosal membrane and also prolong release of drug from delivery system. In the present study, HPMC (release retarding polymer) and mannitol (diluent and pore former) were used to prepare bioadhesive and controlled release buccal discs of buspirone hydrochloride (BS) by direct compression method. Compatibility of BS with various excipients used during the study was assessed using DSC and FTIR techniques. Effect of mannitol and HPMC on drug release and bioadhesive strength was studied using a 3(2) factorial design. The drug release rate from delivery system decreased with increasing levels of HPMC in formulations. However, bioadhesive strength of formulations increased with increasing proportion of HPMC in buccal discs. Increased levels of mannitol resulted in faster rate of drug release and rapid in vitro uptake of water due to the formation of channels in the matrix. Pharmacokinetic studies of designed bioadhesive buccal discs in rabbits demonstrated a 10-fold increase in bioavailability in comparison with oral bioavailability of buspirone reported.

  2. Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

    DEFF Research Database (Denmark)

    Boetker, Johan P; Savolainen, Marja; Koradia, Vishal

    2011-01-01

    Traditional dissolution testing determines drug release to the bulk, but does not enable an understanding of the events happening close to the surface of a solid or a tablet. UV imaging is a new imaging approach that can be used to study the dissolution behavior of chemical compounds. The UV imag...

  3. Research on the biological activity and doxorubicin release behavior in vitro of mesoporous bioactive SiO2-CaO-P2O5 glass nanospheres

    Science.gov (United States)

    Wang, Xiang; Wang, Gen; Zhang, Ying

    2017-10-01

    Mesoporous bioactive glass (MBG) nanospheres have been synthesized by a facile method of sacrificing template using cetyl trimethyl ammonium bromide (CTAB) as surfactant. The prepared MBG nanospheres possess high specific surface area (632 m2 g-1) as well as uniform size (∼100 nm). In addition, MBG nanospheres exhibited a quick in vitro bioactive response in simulated body fluids (SBF) and excellent bioactivity of inducing hydroxyapatite (HA) forming on the surface of MBG nanospheres. Furthermore, MBG nanospheres can sustain release of doxorubicin (DOX) with a higher encapsulation efficiency (63.6%) and show distinct degradation in PBS by releasing Si and Ca ions. The encapsulation efficiency and DOX release of MBG nanospheres could be controlled by mesoporous structure and local pH environment. The greater surface area and pore volumes of prepared MBG nanospheres are conducive to bioactive response and drug release in vitro. The amino groups in DOX can be easily protonated at acidic medium to become positively charged NH+3, which allow these drug molecules to be desorbed from the surface of MBG nanospheres via electrostatic effect. Therefore, the synthesized MBG nanospheres have a pH-sensitive drug release capability. In addition, the cytotoxicity of MBG nanospheres was assessed using a cell counting kit-8 (CCK-8), and results showed that the synthesized MBG nanospheres had no significant cytotoxicity to MC3T3 cells. These all indicated that as-prepared MBG nanospheres are promising candidates for bone tissue engineering.

  4. Effectiveness of water-air and octanol-air partition coefficients to predict lipophilic flavor release behavior from O/W emulsions.

    Science.gov (United States)

    Tamaru, Shunji; Igura, Noriyuki; Shimoda, Mitsuya

    2018-01-15

    Flavor release from food matrices depends on the partition of volatile flavor compounds between the food matrix and the vapor phase. Thus, we herein investigated the relationship between released flavor concentrations and three different partition coefficients, namely octanol-water, octanol-air, and water-air, which represented the oil, water, and air phases present in emulsions. Limonene, 2-methylpyrazine, nonanal, benzaldehyde, ethyl benzoate, α-terpineol, benzyl alcohol, and octanoic acid were employed. The released concentrations of these flavor compounds from oil-in-water (O/W) emulsions were measured under equilibrium using static headspace gas chromatography. The results indicated that water-air and octanol-air partition coefficients correlated with the logarithms of the released concentrations in the headspace for highly lipophilic flavor compounds. Moreover, the same tendency was observed over various oil volume ratios in the emulsions. Our findings therefore suggest that octanol-air and water-air partition coefficients can be used to predict the released concentration of lipophilic flavor compounds from O/W emulsions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. In Vitro Inhibition of Histamine Release Behavior of Cetirizine Intercalated into Zn/Al- and Mg/Al-Layered Double Hydroxides

    Directory of Open Access Journals (Sweden)

    Muhammad Nazrul Hakim

    2012-05-01

    Full Text Available The intercalation of cetirizine into two types of layered double hydroxides, Zn/Al and Mg/Al, has been investigated by the ion exchange method to form CTZAN and CTMAN nanocomposites, respectively. The basal spacing of the nanocomposites were expanded to 31.9 Å for CTZAN and 31.2 Å for CTMAN, suggesting that cetirizine anion was intercalated into Layered double hydroxides (LDHs and arranged in a tilted bilayer fashion. A Fourier transform infrared spectroscopy (FTIR study supported the formation of both the nanocomposites, and the intercalated cetirizine is thermally more stable than its counterpart in free state. The loading of cetirizine in the nanocomposite was estimated to be about 57.2% for CTZAN and 60.7% CTMAN. The cetirizine release from the nanocomposites show sustained release manner and the release rate of cetirizine from CTZAN and CTMAN nanocomposites at pH 7.4 is remarkably lower than that at pH 4.8, presumably due to the different release mechanism. The inhibition of histamine release from RBL2H3 cells by the free cetirizine is higher than the intercalated cetirizine both in CTZAN and CTMAN nanocomposites. The viability in human Chang liver cells at 1000 μg/mL for CTZAN and CTMAN nanocomposites are 74.5 and 91.9%, respectively.

  6. A study on the factors that contribute to the practice of organizational behavior as coping with unexpected events. Exploration of the factors through the case survey of the Great East Japan Earthquake

    International Nuclear Information System (INIS)

    Hayase, Kenichi

    2016-01-01

    In the organizations in the face of unexpected events in the 2011 Great East Japan Earthquake, the organizational behavior which was coped with by their members was seen. It is important to prepare emergency that the backgrounds of those organizational behavior were understood. This study aimed to explore the factors that contribute to the practice of organizational behavior as coping with unexpected events through the case survey of the Great East Japan Earthquake. This study carried out literature survey and interview survey of personnel in charge of disaster prevention, BCP in the 10 organizations which coped with the earthquake. As the result, the following two outcomes were obtained. 1) Factors that contribute to the practice of the 13 kinds of the organizational behavior were clarified. 2) Discussion from the view point of the factors classification indicated the importance of the factors which are classified into normal business and features of organization. (author)

  7. The role of auditory transient and deviance processing in distraction of task performance: a combined behavioral and event-related brain potential study

    Directory of Open Access Journals (Sweden)

    Stefan eBerti

    2013-07-01

    Full Text Available Distraction of goal-oriented performance by a sudden change in the auditory environment is an everyday life experience. Different types of changes can be distracting, including a sudden onset of a transient sound and a slight deviation of otherwise regular auditory background stimulation. With regard to deviance detection, it is assumed that slight changes in a continuous sequence of auditory stimuli are detected by a predictive coding mechanisms and it has been demonstrated that this mechanism is capable of distracting ongoing task performance. In contrast, it is open whether transient detection – which does not rely on predictive coding mechanisms – can trigger behavioral distraction, too. In the present study, the effect of rare auditory changes on visual task performance is tested in an auditory-visual cross-modal distraction paradigm. The rare changes are either embedded within a continuous standard stimulation (triggering deviance detection or are presented within an otherwise silent situation (triggering transient detection. In the event-related brain potentials, deviants elicited the mismatch negativity (MMN while transients elicited an enhanced N1 component, mirroring pre-attentive change detection in both conditions but on the basis of different neuro-cognitive processes. These sensory components are followed by attention related ERP components including the P3a and the reorienting negativity (RON. This demonstrates that both types of changes trigger switches of attention. Finally, distraction of task performance is observable, too, but the impact of deviants is higher compared to transients. These findings suggest different routes of distraction allowing for the automatic processing of a wide range of potentially relevant changes in the environment as a pre-requisite for adaptive behavior.

  8. Stressful life events, ethnic identity, historical trauma, and participation in cultural activities: Associations with smoking behaviors among American Indian adolescents in California.

    Science.gov (United States)

    Soto, Claradina; Baezconde-Garbanati, Lourdes; Schwartz, Seth J; Unger, Jennifer B

    2015-11-01

    American Indian (AI) adolescents have the highest prevalence of commercial tobacco use of any ethnic group in the United States. This study examines ethnic identity (EI), participation in cultural activities, and stressful life events (SLEs) as correlates of smoking and examines historical trauma (HT) as a mediator of these associations. California AI youth (N = 969, ages 13-19, recruited from 49 tribal youth organizations and cultural activities in urban and reservation areas in California) completed a tobacco survey. Structural equation modeling was used to test a model examining HT as a potential mediator of the associations of EI, participation in cultural activities, and SLEs with cigarette smoking. Model fit was adequate. EI, participation in cultural activities, and SLEs predicted HT. HT mediated the associations of participation in cultural activities and SLEs with past-month smoking. Stronger EI predicted greater past-month smoking and this effect was mediated by greater HT. The direct effects from HT to both smoking outcomes were positive and the direct effect from EI to past-month smoking was negative. HT is a risk factor for cigarette smoking both directly and in mediating the links of EI, cultural activities, and SLEs. More efforts are needed to help AI youth to process these thoughts and empower themselves to contribute to their own lives and those of their families and communities without resorting to unhealthy addictive behaviors such as commercial tobacco use. Published by Elsevier Ltd.

  9. A population-based longitudinal study of recent stressful life events as risk factors for suicidal behavior in major depressive disorder.

    Science.gov (United States)

    Wang, Yunqiao; Sareen, Jitender; Afifi, Tracie O; Bolton, Shay-Lee; Johnson, Edward A; Bolton, James M

    2015-01-01

    The purpose of this study is to investigate whether the type and number of stressful life events (SLEs) will be associated with suicidal behavior in a 3-year follow-up period in persons with major depressive disorder (MDD). Data came from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative longitudinal survey of mental health in non-institutionalized adults in the United States. The survey consisted of two waves: Wave 1 (2001--2002) and Wave 2 (2004-2005), n = 34,653. Twelve past-year SLEs were assessed at baseline. These SLEs were categorized into the following groups based on previous research: Loss or victimization; Relationship, friendship, or interpersonal stress; Financial stress; and Legal problems. Only respondents with MDD at Wave 1 were included (n = 6,004). Several SLEs were strongly associated with suicide attempts, among which, "serious problems with neighbor, friend, or relative" (adjusted odds ratio [AOR] = 2.21; 95% confidence interval [95% CI]: 1.41, 3.45) and "major financial crisis, bankruptcy, or unable to pay bills" (AOR = 2.31; 95% CI: 1.45, 3.66) were the most robust predictors of suicide attempts even after adjusting for sociodemographic variables and any anxiety, substance use, or personality disorder. People with MDD who had been exposed to certain SLEs are at elevated risk for future suicide attempts, even after accounting for the demographic factors and psychiatric comorbidity.

  10. Three-dimensional Printed Scaffolds with Gelatin and Platelets Enhance In vitro Preosteoblast Growth Behavior and the Sustained-release Effect of Growth Factors

    Directory of Open Access Journals (Sweden)

    Wei Zhu

    2016-01-01

    Conclusions: Our experiments confirmed that the 3D printed scaffolds we had designed could provide a sustained-release effect for growth factors and improve the proliferation of preosteoblasts with little cytotoxicity in vitro. They may hold promise as bone graft substitute materials in the future.

  11. Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System

    Directory of Open Access Journals (Sweden)

    Dena Dorniani

    2014-01-01

    Full Text Available The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively.

  12. Release behavior and toxicity profiles towards leukemia (WEHI-3B) cell lines of 6-mercaptopurine-PEG-coated magnetite nanoparticles delivery system.

    Science.gov (United States)

    Dorniani, Dena; Kura, Aminu Umar; Hussein-Al-Ali, Samer Hasan; bin Hussein, Mohd Zobir; Fakurazi, Sharida; Shaari, Abdul Halim; Ahmad, Zalinah

    2014-01-01

    The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP) in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively.

  13. Ethnic Variables and Negative Life Events as Predictors of Depressive Symptoms and Suicidal Behaviors in Latino College Students: On the Centrality of "Receptivo a los Demás"

    Science.gov (United States)

    Chang, Edward C.; Yu, Elizabeth A.; Yu, Tina; Kahle, Emma R.; Hernandez, Viviana; Kim, Jean M.; Jeglic, Elizabeth L.; Hirsch, Jameson K.

    2016-01-01

    In the present study, we examined ethnic variables (viz., multigroup ethnic identity and other group orientation) along with negative life events as predictors of depressive symptoms and suicidal behaviors in a sample of 156 (38 male and 118 female) Latino college students. Results of conducting hierarchical regression analyses indicated that the…

  14. Methane release

    International Nuclear Information System (INIS)

    Seifert, M.

    1999-01-01

    The Swiss Gas Industry has carried out a systematic, technical estimate of methane release from the complete supply chain from production to consumption for the years 1992/1993. The result of this survey provided a conservative value, amounting to 0.9% of the Swiss domestic output. A continuation of the study taking into account new findings with regard to emission factors and the effect of the climate is now available, which provides a value of 0.8% for the target year of 1996. These results show that the renovation of the network has brought about lower losses in the local gas supplies, particularly for the grey cast iron pipelines. (author)

  15. A database on tritium behavior in the chronic HT release experiment. 1. Meteorological data and tritium concentrations in air and soil

    Energy Technology Data Exchange (ETDEWEB)

    Noguchi, Hiroshi; Yokoyama, Sumi; Kinouchi, Nobuyuki; Murata, Mikio; Amano, Hikaru; Ando, Mariko [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Fukutani, Satoshi

    1999-03-01

    This report comprises a database that can be used to develop and validate tritium models to assess doses to the general public due to HT continuously released from fusion facilities into the atmosphere. The data was collected in the 1994 chronic HT release experiment carried out at the Chalk River Laboratories in Canada. The data set include meteorological conditions such as solar radiation, net solar radiation, wind speed, air temperature and humidity, soil temperature and soil heat flux; soil conditions such as bulk density, water content and free pore volume fraction; HT and HTO concentrations in air, HTO concentrations in soil moisture and HTO deposition to water surface. Evapo-transpiration rates and turbulent diffusivity are estimated and tabulated. The report also contains experimental methods to observe meteorological conditions and take air and soil samples. (author)

  16. Significant event of patient radiation protection in radiotherapy (criterion 2.1): declaration and rating on the ASN-SFRO scale - ASN guide nr 16 - Release of the 01/01/2010

    International Nuclear Information System (INIS)

    2010-01-01

    This document brings together all the tools for the management of a significant event in radiation protection concerning a patient in radiotherapy. It contains the declaration form, a model for the reporting of significant events, and the ASN-SFRO scale which allows the event to be rated. After a presentation of the regulatory context and references, of the scope of application, this guide addresses the declaration of a significant event: general principles, definition of the 2.1 criterion, examples, delays and modalities of declaration, addressees of a declaration. It addresses the reporting of a significant event: general principles, sending delays and modalities. It addresses the rating on the ASN-SFRO scale: general principles, scale, and rating process. The last part deals with public information

  17. Significant event of patient radiation protection in radiotherapy (criterion 2.1): declaration and rating on the ASN-SFRO scale - ASN guide no. 16 - Release of 17/07/2015

    International Nuclear Information System (INIS)

    2015-01-01

    This document is an update of the previous version from October 2010. It brings together all the tools for the management of a significant event in radiation protection concerning a patient in radiotherapy. It contains the declaration form, a model for the reporting of significant events, and the ASN-SFRO scale which allows the event to be rated. After a presentation of the regulatory context and references, of the scope of application, this guide addresses the declaration of a significant event: general principles, definition of the 2.1 criterion, examples, delays and modalities of declaration, addressees of a declaration. It addresses the reporting of a significant event: general principles, sending delays and modalities. It addresses the rating on the ASN-SFRO scale: general principles, scale, and rating process. The last part deals with public information

  18. Plutonium behavior during the early diagenesis of marine sediments: applications to two marine environments labelled by radionuclides released from reprocessing plants

    International Nuclear Information System (INIS)

    Gouzy, A.

    2004-12-01

    The plutonium released into the English Channel and the Irish Sea by nuclear fuel reprocessing plants is mainly associated to sediments. Nevertheless, this association is partially reversible. This work combines a field study, carried out on the Cumbrian mud patch and the Esk estuary (Eastern Irish Sea), and laboratory experiments performed on carbonaceous coarse-grained sediments collected in the Central Channel. It presents new data on the plutonium solid partition in sediments and suggests realistic scenarios for describing its release from sediments to the water column. The role of reactive sulphides acting as temporary sink phases is shown in anoxic sediments; those sulphides are liable to release dissolved plutonium upon their oxidation. The plutonium is also bound to carbonates within the carbonaceous matrix and as carbonate surface complexes. Conceptual schemes of the behaviour of the plutonium in marine sediments are proposed; they highlight the strong remobilization potential of plutonium from marine sediments to the interstitial water. Its plutonium content can be injected into the overlying water column. (author)

  19. COMMERCIAL SNF ACCIDENT RELEASE FRACTIONS

    Energy Technology Data Exchange (ETDEWEB)

    S.O. Bader

    1999-10-18

    The purpose of this design analysis is to specify and document the total and respirable fractions for radioactive materials that are released from an accident event at the Monitored Geologic Repository (MGR) involving commercial spent nuclear fuel (CSNF) in a dry environment. The total and respirable release fractions will be used to support the preclosure licensing basis for the MGR. The total release fraction is defined as the fraction of total CSNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. The radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses. This subset of the total release fraction is referred to as the respirable release fraction. Potential accidents may involve waste forms that are characterized as either bare (unconfined) fuel assemblies or confined fuel assemblies. The confined CSNF assemblies at the MGR are contained in shipping casks, canisters, or disposal containers (waste packages). In contrast to the bare fuel assemblies, the container that confines the fuel assemblies has the potential of providing an additional barrier for diminishing the total release fraction should the fuel rod cladding breach during an accident. However, this analysis will not take credit for this additional bamer and will establish only the total release fractions for bare unconfined CSNF assemblies, which may however be

  20. COMMERCIAL SNF ACCIDENT RELEASE FRACTIONS

    International Nuclear Information System (INIS)

    S.O. Bader

    1999-01-01

    The purpose of this design analysis is to specify and document the total and respirable fractions for radioactive materials that are released from an accident event at the Monitored Geologic Repository (MGR) involving commercial spent nuclear fuel (CSNF) in a dry environment. The total and respirable release fractions will be used to support the preclosure licensing basis for the MGR. The total release fraction is defined as the fraction of total CSNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. The radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses. This subset of the total release fraction is referred to as the respirable release fraction. Potential accidents may involve waste forms that are characterized as either bare (unconfined) fuel assemblies or confined fuel assemblies. The confined CSNF assemblies at the MGR are contained in shipping casks, canisters, or disposal containers (waste packages). In contrast to the bare fuel assemblies, the container that confines the fuel assemblies has the potential of providing an additional barrier for diminishing the total release fraction should the fuel rod cladding breach during an accident. However, this analysis will not take credit for this additional bamer and will establish only the total release fractions for bare unconfined CSNF assemblies, which may however be

  1. 1,3,5-Triazine-2,4,6-tribenzaldehyde derivative as a new crosslinking agent for synthesis of pH-thermo dual responsive chitosan hydrogels and their nanocomposites: Swelling properties and drug release behavior.

    Science.gov (United States)

    Karimi, Ali Reza; Tarighatjoo, Mahsa; Nikravesh, Golara

    2017-12-01

    In this work, 1,3,5-triazine-2,4,6-tribenzaldehyde was synthesized and chosen as the cross-linking agent for preparation of novel thermo- and pH-responsive hydrogels based on chitosan. The cross-linking proceeds through formation of imine bond by reaction of amino groups of chitosan with aldehyde groups of the cross-linker. The various amounts (6, 10, 14% w/w) of the cross-linker were used with respect to chitosan to produce three 1,3,5-triazine-2,4,6-tribenzaldehyde cross-linked chitosans. Then, their hydrogel nanocomposites were prepared by crosslinking of chitosan with 1,3,5-triazine-2,4,6-tribenzaldehyde in the presence of 0.1% and 0.3% (w/w) multi-walled carbon nanotubes (MWCNTs). The structure and properties of the hydrogels and their nanocomposites were characterized by FT-IR, 1 H NMR and scanning electron microscopy (SEM). The swelling behavior of prepared hydrogels and their nanocomposites at different pHs and temperatures was investigated. The results showed that they exhibit a pH and temperature-responsive swelling ratio. The swelling behavior of the prepared chitosan hydrogels was strongly dependent on the amounts of cross-linker and MWCNTs. In vitro controlled release behavior of metronidazole model drug was studied with prepared hydrogels and nanocomposite hydrogels. The pH, temperature and wt% of MWCNTs were found to strongly influence the drug release behavior of the hydrogels. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. The Reinforcing Event (RE) Menu

    Science.gov (United States)

    Addison, Roger M.; Homme, Lloyd E.

    1973-01-01

    A motivational system, the Contingency Management System, uses contracts in which some amount of defined task behavior is demanded for some interval of reinforcing event. The Reinforcing Event Menu, a list of high probability reinforcing behaviors, is used in the system as a prompting device for the learner and as an aid for the administrator in…

  3. Fabrication of a microfluidic device for studying the in situ drug-loading/release behavior of graphene oxide-encapsulated hydrogel beads.

    Science.gov (United States)

    Veerla, Sarath Chandra; Kim, Da Reum; Yang, Sung Yun

    2018-01-01

    Controlled drug delivery system is highly important for not only prolonged the efficacy of drug but also cellular development for tissue engineering. A number of biopolymer composites and nanostructured carriers behave been used for the controlled drug delivery of therapeutics. Recently, in vitro microfluidic devices that mimic the human body have been developed for drug-delivery applications. A microfluidic channel was fabricated via a two-step process: (i) polydimethyl siloxane (PDMS) and curing agent were poured with a 10:2 mass ratio onto an acrylic mold with two steel pipes, and (ii) calcium alginate beads were synthesized using sodium alginate and calcium chloride solutions. Different amounts (10, 25, 50 μg) of graphene oxide (GO) were then added by Hummers method, and studies on the encapsulation and release of the model drug, risedronate (Ris), were performed using control hydrogel beads (pH 6.3), GO-containing beads (10GO, 25GO and 50GO), and different pH conditions. MC3T3 osteoblastic cells were cultured in a microchannel with Ris-loaded GO-hydrogel beads, and their proliferation, viability, attachment and spreading were assessed for a week. The spongy and textured morphology of pristine hydrogel beads was converted to flowery and rod-shaped structures in drug-loaded hydrogel beads at reduced pH (6.3) and at a lower concentration (10 μg) of GO. These latter 10GO drug-loaded beads rapidly released their cargo owing to the calcium phosphate deposited on the surface. Notably, beads containing a higher amount of GO (50GO) exhibited an extended drug-release profile. We further found that MC3T3 cells proliferated continuously in vitro in the microfluidic channel containing the GO-hydrogel system. MTT and live/dead assays showed similar proliferative potential of MC3T3 cells. Therefore, a microfluidic device with microchannels containing hydrogel beads formulated with different amounts of GO and tested under various pH conditions could be a promising system

  4. Event Investigation

    International Nuclear Information System (INIS)

    Korosec, D.

    2000-01-01

    The events in the nuclear industry are investigated from the license point of view and from the regulatory side too. It is well known the importance of the event investigation. One of the main goals of such investigation is to prevent the circumstances leading to the event and the consequences of the event. The protection of the nuclear workers against nuclear hazard, and the protection of general public against dangerous effects of an event could be achieved by systematic approach to the event investigation. Both, the nuclear safety regulatory body and the licensee shall ensure that operational significant events are investigated in a systematic and technically sound manner to gather information pertaining to the probable causes of the event. One of the results should be appropriate feedback regarding the lessons of the experience to the regulatory body, nuclear industry and general public. In the present paper a general description of systematic approach to the event investigation is presented. The systematic approach to the event investigation works best where cooperation is present among the different divisions of the nuclear facility or regulatory body. By involving management and supervisors the safety office can usually improve their efforts in the whole process. The end result shall be a program which serves to prevent events and reduce the time and efforts solving the root cause which initiated each event. Selection of the proper method for the investigation and an adequate review of the findings and conclusions lead to the higher level of the overall nuclear safety. (author)

  5. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex.

    Science.gov (United States)

    Chiba, Shuichi; Numakawa, Tadahiro; Ninomiya, Midori; Richards, Misty C; Wakabayashi, Chisato; Kunugi, Hiroshi

    2012-10-01

    Stress and the resulting increase in glucocorticoid levels have been implicated in the pathophysiology of depressive disorders. We investigated the effects of chronic restraint stress (CRS: 6 hours × 28 days) on anxiety- and depression-like behaviors in rats and on the possible changes in glucocorticoid receptor (GR) expression as well as brain-derived neurotrophic factor (BDNF)-dependent neural function in the prefrontal cortex (PFC). We observed significant reductions in body weight gain, food intake and sucrose preference from 1 week after the onset of CRS. In the 5th week of CRS, we conducted open-field (OFT), elevated plus-maze (EPM) and forced swim tests (FST). We observed a decrease in the number of entries into open arms during the EPM (anxiety-like behavior) and increased immobility during the FST (depression-like behavior). When the PFC was removed after CRS and subject to western blot analysis, the GR expression reduced compared with control, while the levels of BDNF and its receptors remained unchanged. Basal glutamate concentrations in PFC acute slice which were measured by high performance liquid chromatography were not influenced by CRS. However, BDNF-induced glutamate release was attenuated after CRS. These results suggest that reduced GR expression and altered BDNF function may be involved in chronic stress-induced anxiety--and depression-like behaviors. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Problemas Comportamentales y Sucesos de Vida en Niños de 6 a 11 Años de Edad Behavioral Problems and Life Events in 6 to 11 Years Old Children

    Directory of Open Access Journals (Sweden)

    Virginia Corina Samaniego

    2005-11-01

    Full Text Available Desde la epidemiología la relación entre sucesos de vida y trastornos psíquicos infantiles no es tan clara. El rol etiológico directo asignado a los eventos vitales podría reducirse al considerar los niveles de problemas previos a los eventos. Se examinó en una muestra de población general de niños de 6 a 11 años (N = 69 la asociación entre sucesos de vida y cambios en el grado de problemas comportamentales. Los sucesos fueron predictores del nivel actual de problemas comportamentales, siendo un hallazgo estadísticamente significativo. Sin embargo, al incluir el nivel de problemas previo a los eventos ese efecto se redujo y fue el nivel inicial de problemas el mejor predictor. Los resultados dan soporte a la hipótesis en estudio.From an epidemiological perspective the relationship between life events and psychological disorders in children is not so clear. The direct etiological role given to life events might be diminish when considering the level of psychological disorders previous to the events. The association among life events and changes in the level of behavioral and emotional problems in a general sample of 6-11 years old children (N = 69 was investigated. Life events predicted the actual level of behavioral problems. However, when including the initial level of problems the life events effect lessened. The initial level of behavioral problems was the better predictor of the actual level. The findings give support to the hypothesis under study.

  7. Coupled calculation of the radiological release and the thermal-hydraulic behavior of a 3-loop PWR after a SGTR by means of the code RELAP5

    Energy Technology Data Exchange (ETDEWEB)

    Van Hove, W.; Van Laeken, K.; Bartsoen, L. [Belgatom, Brussels (Belgium)] [and others

    1995-09-01

    To enable a more realistic and accurate calculation of the radiological consequences of a SGTR, a fission product transport model was developed. As the radiological releases strongly depend on the thermal-hydraulic transient, the model was included in the RELAP5 input decks of the Belgian NPPs. This enables the coupled calculation of the thermal-hydraulic transient and the radiological release. The fission product transport model tracks the concentration of the fission products in the primary circuit, in each of the SGs as well as in the condenser. This leads to a system of 6 coupled, first order ordinary differential equations with time dependent coefficients. Flashing, scrubbing, atomisation and dry out of the break flow are accounted for. Coupling with the thermal-hydraulic calculation and correct modelling of the break position enables an accurate calculation of the mixture level above the break. Pre- and post-accident spiking in the primary circuit are introduced. The transport times in the FW-system and the SG blowdown system are also taken into account, as is the decontaminating effect of the primary make-up system and of the SG blowdown system. Physical input parameters such as the partition coefficients, half life times and spiking coefficients are explicitly introduced so that the same model can be used for iodine, caesium and noble gases.

  8. Serotonin release in the caudal nidopallium of adult laying hens genetically selected for high and low feather pecking behavior: An in vivo microdialysis study

    NARCIS (Netherlands)

    Kops, M.S.; Kjaer, J.B.; Güntürkün, O.; Westphal, K.C.G.; Korte-Bouws, G.A.H.; Olivier, B.; Bolhuis, J.E.; Korte, S.M.

    2014-01-01

    Severe feather pecking (FP) is a detrimental behavior causing welfare problems in laying hens. Divergent genetic selection for FP in White Leghorns resulted in strong differences in FP incidences between lines. More recently, it was shown that the high FP (HFP) birds have increased locomotor

  9. Parametric study of radioactive release from a breached containment

    International Nuclear Information System (INIS)

    Kenigsberg, A.; Hasan, D.; Elias, E.

    1980-01-01

    A hypothetical accident is analyzed, in which an external (out-of-plant) natural or man-made event causes a loss-of-coolant accident after penetrating the containment wall. The computer codes CONTEMPT and RELAP4 have been used to study the containment thermal-hydraulic behavior during the accident. Results are given in the form of graphs showing the thermal-hydraulic response of the containment and the profile of radioactive release to the atmosphere. The physical model and input data are discussed. 13 refs

  10. Eating behavior and stress: a pathway to obesity

    OpenAIRE

    Sominsky, Luba; Spencer, Sarah J.

    2014-01-01

    Stress causes or contributes to a huge variety of diseases and disorders. Recent evidence suggests obesity and other eating-related disorders may be among these. Immediately after a stressful event is experienced, there is a corticotropin-releasing-hormone (CRH)-mediated suppression of food intake. This diverts the body’s resources away from the less pressing need to find and consume food, prioritizing fight, flight, or withdrawal behaviors so the stressful event can be dealt with. In the hou...

  11. Fission product iodine during early Hanford-Site operations: Its production and behavior during fuel processing, off-gas treatment and release to the atmosphere

    International Nuclear Information System (INIS)

    Burger, L.L.

    1991-05-01

    The Hanford Environmental Dose Reconstruction (HEDR) Project was established to estimate the radiological dose impact that Hanford Site operations may have made on the local and regional population. This impact is estimated by examining operations involving radioactive materials that were conducted at the Hanford Site from the startup of the first reactor in 1944 to the present. HEDR Project work is divided among several technical tasks. One of these tasks, Source Terms, is designed to develop quantitative estimates of all significant emissions of radionuclides by Hanford Site operations since 1944. Radiation doses can be estimated from these emissions by accounting for specific radionuclide transport conditions and population demography. This document provides technical information to assist in the evaluation of iodine releases. 115 refs., 5 figs., 3 tabs

  12. Fission product iodine during early Hanford-Site operations: Its production and behavior during fuel processing, off-gas treatment and release to the atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Burger, L.L.

    1991-05-01

    The Hanford Environmental Dose Reconstruction (HEDR) Project was established to estimate the radiological dose impact that Hanford Site operations may have made on the local and regional population. This impact is estimated by examining operations involving radioactive materials that were conducted at the Hanford Site from the startup of the first reactor in 1944 to the present. HEDR Project work is divided among several technical tasks. One of these tasks, Source Terms, is designed to develop quantitative estimates of all significant emissions of radionuclides by Hanford Site operations since 1944. Radiation doses can be estimated from these emissions by accounting for specific radionuclide transport conditions and population demography. This document provides technical information to assist in the evaluation of iodine releases. 115 refs., 5 figs., 3 tabs.

  13. Corticotropin-releasing Factor in the Rat Dorsal Raphe Nucleus Promotes Different Forms of Behavioral Flexibility Depending on Social Stress History.

    Science.gov (United States)

    Snyder, Kevin P; Hill-Smith, Tiffany E; Lucki, Irwin; Valentino, Rita J

    2015-10-01

    The stress-related neuropeptide, corticotropin-releasing factor (CRF) regulates the dorsal raphe nucleus-serotonin (DRN-5-HT) system during stress and this may underlie affective and cognitive dysfunctions that characterize stress-related psychiatric disorders. CRF acts on both CRF1 and CRF2 receptor subtypes in the DRN that exert opposing inhibitory and excitatory effects on DRN-5-HT neuronal activity and 5-HT forebrain release, respectively. The current study first assessed the cognitive effects of intra-DRN microinfusion of CRF or the selective CRF2 agonist, urocortin II in stress-naive rats on performance of an operant strategy set-shifting task that is mediated by the medial prefrontal cortex (mPFC). CRF (30 ng) facilitated strategy set-shifting performance, whereas higher doses of CRF and urocortin II that would interact with CRF2 were without effect, consistent with a CRF1-mediated action. This dose decreased 5-HT extracellular levels in the mPFC, further supporting a role for CRF1. The effects of CRF were then assessed in rats exposed to repeated social stress using the resident-intruder model. Repeated social stress shifted the CRF effect from facilitation of strategy set shifting to facilitation of reversal learning and this was most prominent in a subpopulation of rats that resist defeat. Notably, in this subpopulation of rats 5-HT neuronal responses to CRF have been demonstrated to shift from CRF1-mediated inhibition to CRF2-mediated excitation. Because 5-HT facilitates reversal learning, the present results suggest that stress-induced changes in the cellular effects of CRF in the DRN translate to changes in cognitive effects of CRF. Together, the results underscore the potential for stress history to shift cognitive processing through changes in CRF neurotransmission in the DRN and the association of this effect with coping strategy.

  14. Data Analysis of Transient Energy Releases in the LHC Superconducting Dipole Magnets

    CERN Document Server

    Calvi, M; Bottura, L; Di Castro, M; Masi, A; Siemko, A

    2007-01-01

    Premature training quenches are caused by transient energy released within the LHC dipole magnet coils while it is energized. Voltage signals recorded across the magnet coils and on the so-called quench antenna carry information about these disturbances. The transitory events correlated to transient energy released are extracted making use of continuous wavelet transform. Several analyses are performed to understand their relevance to the so called training phenomenon. The statistical distribution of the signals amplitude, the number of events occurring at a given current level, the average frequency content of the events are the main parameters on which the analysis have been focalized. Comparisons among different regions of the magnet, among different quenches in the same magnet and among magnets made by different builders are reported. Conclusions about the efficiency of the raw data treatment and the relevance of the parameters developed with respect to the magnet global behavior are finally given.

  15. SENTINEL EVENTS

    Directory of Open Access Journals (Sweden)

    Andrej Robida

    2004-09-01

    Full Text Available Background. The Objective of the article is a two year statistics on sentinel events in hospitals. Results of a survey on sentinel events and the attitude of hospital leaders and staff are also included. Some recommendations regarding patient safety and the handling of sentinel events are given.Methods. In March 2002 the Ministry of Health introduce a voluntary reporting system on sentinel events in Slovenian hospitals. Sentinel events were analyzed according to the place the event, its content, and root causes. To show results of the first year, a conference for hospital directors and medical directors was organized. A survey was conducted among the participants with the purpose of gathering information about their view on sentinel events. One hundred questionnaires were distributed.Results. Sentinel events. There were 14 reports of sentinel events in the first year and 7 in the second. In 4 cases reports were received only after written reminders were sent to the responsible persons, in one case no reports were obtained. There were 14 deaths, 5 of these were in-hospital suicides, 6 were due to an adverse event, 3 were unexplained. Events not leading to death were a suicide attempt, a wrong side surgery, a paraplegia after spinal anaesthesia, a fall with a femoral neck fracture, a damage of the spleen in the event of pleural space drainage, inadvertent embolization with absolute alcohol into a femoral artery and a physical attack on a physician by a patient. Analysis of root causes of sentinel events showed that in most cases processes were inadequate.Survey. One quarter of those surveyed did not know about the sentinel events reporting system. 16% were having actual problems when reporting events and 47% beleived that there was an attempt to blame individuals. Obstacles in reporting events openly were fear of consequences, moral shame, fear of public disclosure of names of participants in the event and exposure in mass media. The majority of

  16. Radionuclide Release after LBLOCA with Loss of Class IV Power Accident in CANDU-6 Plant

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hoon [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2011-10-15

    A large break in a pipe train of a primary heat transport system discharges coolant, which has high energy and large mass, into the containment building. Reactor shutdown and emergency core cooling water will limit the fuel cladding failure, but cannot prevent it entirely. The containment building is the last barrier of radionuclide release to the environment. Containment isolation and pressure suppression by dousing and local air cooler reduce the amount of radionuclide release to the environment. The objective of containment behavior analysis for large break loss of coolant with loss of class IV power accident is to assess the amount of radionuclide release to the ambient atmosphere. Radionuclide release rates in this event, with all safety system available, that is, the containment building is intact, as well as with containment system impairment, are analyzed with GOTHIC and SMART code

  17. Concentration-discharge relationships during an extreme event: Contrasting behavior of solutes and changes to chemical quality of dissolved organic material in the Boulder Creek Watershed during the September 2013 flood: SOLUTE FLUX IN A FLOOD EVENT

    Energy Technology Data Exchange (ETDEWEB)

    Rue, Garrett P. [Institute of Arctic and Alpine Research, University of Colorado, Boulder Colorado USA; Rock, Nathan D. [Institute of Arctic and Alpine Research, University of Colorado, Boulder Colorado USA; Gabor, Rachel S. [Institute of Arctic and Alpine Research, University of Colorado, Boulder Colorado USA; Pitlick, John [Department of Geography, University of Colorado, Boulder Colorado USA; Tfaily, Malak [Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland Washington USA; McKnight, Diane M. [Institute of Arctic and Alpine Research, University of Colorado, Boulder Colorado USA

    2017-07-01

    During the week of September 10-17, 2013, close to 20 inches of rain fell across Boulder County, Colorado, USA. This rainfall represented a 1000-year event that caused massive hillslope erosion, landslides, and mobilization of sediments. The resultant stream flows corresponded to a 100-year flood. For the Boulder Creek Critical Zone Observatory (BC-CZO), this event provided an opportunity to study the effect of extreme rainfall on solute concentration-discharge relationships and biogeochemical catchment processes. We observed base cation and dissolved organic carbon (DOC) concentrations at two sites on Boulder Creek following the recession of peak flow. We also isolated three distinct fractions of dissolved organic matter (DOM) for chemical characterization. At the upper site, which represented the forested mountain catchment, the concentrations of the base cations Ca, Mg and Na were greatest at the peak flood and decreased only slightly, in contrast with DOC and K concentrations, which decreased substantially. At the lower site within urban corridor, all solutes decreased abruptly after the first week of flow recession, with base cation concentrations stabilizing while DOC and K continued to decrease. Additionally, we found significant spatiotemporal trends in the chemical quality of organic matter exported during the flood recession, as measured by fluorescence, 13C-NMR spectroscopy, and FTICR-MS. Similar to the effect of extreme rainfall events in driving landslides and mobilizing sediments, our findings suggest that such events mobilize solutes by the flushing of the deeper layers of the critical zone, and that this flushing regulates terrestrial-aquatic biogeochemical linkages during the flow recession.

  18. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  19. Contact: Releasing the news

    Science.gov (United States)

    Pinotti, Roberto

    The problem of mass behavior after man's future contacts with other intelligences in the universe is not only a challenge for social scientists and political leaders all over the world, but also a cultural time bomb as well. In fact, since the impact of CETI (Contact with Extraterrestrial Intelligence) on human civilization, with its different cultures, might cause a serious socio-anthropological shock, a common and predetermined worldwide strategy is necessary in releasing the news after the contact, in order to keep possible manifestations of fear, panic and hysteria under control. An analysis of past studies in this field and of parallel historical situations as analogs suggests a definite "authority crisis" in the public as a direct consequence of an unexpected release of the news, involving a devastating "chain reaction" process (from both the psychological and sociological viewpoints) of anomie and maybe the collapse of today's society. The only way to prevent all this is to prepare the world's public opinion concerning contact before releasing the news, and to develop a long-term strategy through the combined efforts of scientists, political leaders, intelligence agencies and the mass media, in order to create the cultural conditions in which a confrontation with ETI won't affect mankind in a traumatic way. Definite roles and tasks in this multi-level model are suggested.

  20. Identifying Relationships between High-Risk Sexual Behaviors and Screening Positive for Chlamydia and Gonorrhea in School-Wide Screening Events

    Science.gov (United States)

    Salerno, Jennifer; Darling-Fisher, Cindy; Hawkins, Nicole M.; Fraker, Elizabeth

    2013-01-01

    Background: This article describes a school-wide sexually transmitted infection (STI) screening to identify adolescent high-risk sexual behaviors, STI history/incidence, and presence of chlamydia and gonorrhea, and examines relationships between high-risk behaviors and screening positive for chlamydia and gonorrhea in an alternative high school…

  1. Cross-National Analysis of the Associations between Traumatic Events and Suicidal Behavior : Findings from the WHO World Mental Health Surveys

    NARCIS (Netherlands)

    Stein, Dan J.; Chiu, Wai Tat; Hwang, Irving; Kessler, Ronald C.; Sampson, Nancy; Alonso, Jordi; Borges, Guilherme; Bromet, Evelyn; Bruffaerts, Ronny; de Girolamo, Giovanni; Florescu, Silvia; Gureje, Oye; He, Yanling; Kovess-Masfety, Viviane; Levinson, Daphna; Matschinger, Herbert; Mneimneh, Zeina; Nakamura, Yosikazu; Ormel, Johan; Posada-Villa, Jose; Sagar, Rajesh; Scott, Kate M.; Tomov, Toma; Viana, Maria Carmen; Williams, David R.; Nock, Matthew K.

    2010-01-01

    Background: Community and clinical data have suggested there is an association between trauma exposure and suicidal behavior (i.e., suicide ideation, plans and attempts). However, few studies have assessed which traumas are uniquely predictive of: the first onset of suicidal behavior, the

  2. The sustained-release behavior and in vitro and in vivo transfection of pEGFP-loaded core-shell-structured chitosan-based composite particles

    Science.gov (United States)

    Wang, Yun; Lin, Fu-xing; Zhao, Yu; Wang, Mo-zhen; Ge, Xue-wu; Gong, Zheng-xing; Bao, Dan-dan; Gu, Yu-fang

    2014-01-01

    Novel submicron core-shell-structured chitosan-based composite particles encapsulated with enhanced green fluorescent protein plasmids (pEGFP) were prepared by complex coacervation method. The core was pEGFP-loaded thiolated N-alkylated chitosan (TACS) and the shell was pH- and temperature-responsive hydroxybutyl chitosan (HBC). pEGFP-loaded TACS-HBC composite particles were spherical, and had a mean diameter of approximately 120 nm, as measured by transmission electron microscopy and particle size analyzer. pEGFP showed sustained release in vitro for >15 days. Furthermore, in vitro transfection in human embryonic kidney 293T and human cervix epithelial cells, and in vivo transfection in mice skeletal muscle of loaded pEGFP, were investigated. Results showed that the expression of loaded pEGFP, both in vitro and in vivo, was slow but could be sustained over a long period. pEGFP expression in mice skeletal muscle was sustained for >60 days. This work indicates that these submicron core-shell-structured chitosan-based composite particles could potentially be used as a gene vector for in vivo controlled gene transfection. PMID:25364253

  3. Analysis of in-pile tritium release experiments

    International Nuclear Information System (INIS)

    Kopasz, J.P.; Tam, S.W.; Johnson, C.E.

    1992-01-01

    The objective of this work is to characterize tritium release behavior from lithium ceramics and develop insight into the underlying tritium release mechanisms. Analysis of tritium release data from recent laboratory experiments with lithium aluminate has identified physical processes which were previously unaccounted for in tritium release models. A new model that incorporates the recent data and provides for release from multiple sites rather than only one site was developed. Calculations of tritium release using this model are in excellent agreement with the tritium release behavior reported for the MOZART experiment

  4. Estrogen and voluntary exercise interact to attenuate stress-induced corticosterone release but not anxiety-like behaviors in female rats.

    Science.gov (United States)

    Jones, Alexis B; Gupton, Rebecca; Curtis, Kathleen S

    2016-09-15

    The beneficial effects of physical exercise to reduce anxiety and depression and to alleviate stress are increasingly supported in research studies. The role of ovarian hormones in interactions between exercise and anxiety/stress has important implications for women's health, given that women are at increased risk of developing anxiety-related disorders, particularly during and after the menopausal transition. In these experiments, we tested the hypothesis that estrogen enhances the positive impact of exercise on stress responses by investigating the combined effects of exercise and estrogen on anxiety-like behaviors and stress hormone levels in female rats after an acute stressor. Ovariectomized female rats with or without estrogen were given access to running wheels for one or three days of voluntary running immediately after or two days prior to being subjected to restraint stress. We found that voluntary running was not effective at reducing anxiety-like behaviors, whether or not rats were subjected to restraint stress. In contrast, stress-induced elevations of stress hormone levels were attenuated by exercise experience in estrogen-treated rats, but were increased in rats without estrogen. These results suggest that voluntary exercise may be more effective at reducing stress hormone levels if estrogen is present. Additionally, exercise experience, or the distance run, may be important in reducing stress. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. First Indico Virtual Event

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The first Indico virtual event will take place on February 4th 15:00 and will focus on two main topics The release of Indico v1.2 The migration of the OO Indico backend database (ZODB) to a more standard DBMS It will be fully virtual using the CERN Vidyo service and will foster discussions between developers and administrators of Indico servers worldwide. Connections to the virtual room will be open, but attendees are encouraged to register to the event, in order to be informed of any changes in the organisation if any. If you would like to add a topic of discussion or propose yourself a contribution, please let us know at indico-team@cern.ch. Connection to Vidyo Vidyo connection details are available here CERN Vidyo service documentation can be found here First-time users are encouraged to try the service before connecting to the real event

  6. Differential Dopamine Release Dynamics in the Nucleus Accumbens Core and Shell Reveal Complementary Signals for Error Prediction and Incentive Motivation.

    Science.gov (United States)

    Saddoris, Michael P; Cacciapaglia, Fabio; Wightman, R Mark; Carelli, Regina M

    2015-08-19

    Mesolimbic dopamine (DA) is phasically released during appetitive behaviors, though there is substantive disagreement about the specific purpose of these DA signals. For example, prediction error (PE) models suggest a role of learning, while incentive salience (IS) models argue that the DA signal imbues stimuli with value and thereby stimulates motivated behavior. However, within the nucleus accumbens (NAc) patterns of DA release can strikingly differ between subregions, and as such, it is possible that these patterns differentially contribute to aspects of PE and IS. To assess this, we measured DA release in subregions of the NAc during a behavioral task that spatiotemporally separated sequential goal-directed stimuli. Electrochemical methods were used to measure subsecond NAc dopamine release in the core and shell during a well learned instrumental chain schedule in which rats were trained to press one lever (seeking; SL) to gain access to a second lever (taking; TL) linked with food delivery, and again during extinction. In the core, phasic DA release was greatest following initial SL presentation, but minimal for the subsequent TL and reward events. In contrast, phasic shell DA showed robust release at all task events. Signaling decreased between the beginning and end of sessions in the shell, but not core. During extinction, peak DA release in the core showed a graded decrease for the SL and pauses in release during omitted expected rewards, whereas shell DA release decreased predominantly during the TL. These release dynamics suggest parallel DA signals capable of supporting distinct theories of appetitive behavior. Dopamine signaling in the brain is important for a variety of cognitive functions, such as learning and motivation. Typically, it is assumed that a single dopamine signal is sufficient to support these cognitive functions, though competing theories disagree on how dopamine contributes to reward-based behaviors. Here, we have found that real

  7. The sustained-release behavior and in vitro and in vivo transfection of pEGFP-loaded core-shell-structured chitosan-based composite particles

    Directory of Open Access Journals (Sweden)

    Wang Y

    2014-10-01

    Full Text Available Yun Wang,1 Fu-xing Lin,2 Yu Zhao,1 Mo-zhen Wang,2 Xue-wu Ge,2 Zheng-xing Gong,1 Dan-dan Bao,1 Yu-fang Gu1 1Department of Plastic Surgery, First Affiliated Hospital of Anhui Medical University, 2CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China Abstract: Novel submicron core-shell-structured chitosan-based composite particles ­encapsulated with enhanced green fluorescent protein plasmids (pEGFP were prepared by complex coacervation method. The core was pEGFP-loaded thiolated N-alkylated chitosan (TACS and the shell was pH- and temperature-responsive hydroxybutyl chitosan (HBC. pEGFP-loaded TACS-HBC composite particles were spherical, and had a mean diameter of approximately 120 nm, as measured by transmission electron microscopy and particle size analyzer. pEGFP showed sustained release in vitro for >15 days. Furthermore, in vitro transfection in human embryonic kidney 293T and human cervix epithelial cells, and in vivo transfection in mice skeletal muscle of loaded pEGFP, were investigated. Results showed that the expression of loaded pEGFP, both in vitro and in vivo, was slow but could be sustained over a long period. pEGFP expression in mice skeletal muscle was sustained for >60 days. This work indicates that these submicron core-shell-structured chitosan-based composite particles could potentially be used as a gene vector for in vivo controlled gene transfection. Keywords: gene therapy, gene transfection, hydroxybutyl chitosan, thiolated N-alkylated chitosan, pEGFP, complex coacervation

  8. Amphiphilic polymeric micelles originating from 1,4-β-D-glucan-g-polyphenylene oxide as the carriers for delivery of docetaxel and the corresponding release behaviors.

    Science.gov (United States)

    Yang, Fang; Xiao, Dan; Han, Huaxin; Chen, Yuhuan; Li, Gang

    2018-07-15

    A novel amphiphilic polymeric drug carrier was synthesized through grafting polymerization of water-soluble 1,4-β-D-glucan from cotton cellulose tailored and polypropylene oxide (PPO), and then use thereof to synthesize graft copolymer 1,4-β-D-glucan-PPO-docetaxel (DTX). The products were characterized by FTIR, 1 H NMR, and 13 C NMR. The physicochemical characteristics of 1,4-β-D-glucan-PPO and 1,4-β-D-glucan-PPO-DTX such as molecular weight distribution (MWD), micro-morphology, size, critical micelle concentration (CMC), aggregation number of micelle (N), in vitro stability and drug pharmacokinetic study in vivo were investigated. The results reveal that the degree of polymerization (DP) of the water-soluble 1,4-β-D-glucan from cotton cellulose tailored is equal to 7; the 1,4-β-D-glucan-PPO surfactant possesses good surface activity while the adduct number of propylene oxide reaches appropriately to 20; the DTX is completely dispersed in water medium with 1,4-β-D-glucan-PPO-DTX micelle and the drug conjugated percent is up to 40.3%; In vitro study confirms that 1,4-β-D-glucan-PPO-DTX has the capacity for sustained drug release; In plasma, 1,4-β-D-glucan-PPO-DTX exhibits a significantly enhanced C max , AUC (0-t) and T 1/2 compared with DTX. These results demonstrate that 1,4-β-D-glucan-PPO has the potential to be used as a novel biocompatible biomaterial for drug delivery. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. Fronteiras entre análise do comportamento e fisiologia: Skinner e a temática dos eventos privados Boundaries between behavior analysis and physiology: Skinner and the issue of private events

    Directory of Open Access Journals (Sweden)

    Emmanuel Zagury Tourinho

    2000-01-01

    Full Text Available O presente estudo examinou referências de B. F. Skinner à fisiologia em textos sobre eventos privados, com o objetivo de identificar elementos para uma demarcação mais precisa das relações entre análise do comportamento e fisiologia. As contribuições de Skinner naquela direção foram categorizadas em seis temas: a variáveis biológicas como constitutivas, mas não definidoras do fenômeno comportamental privado; b autonomia do recorte analítico-comportamental diante dos fatos biológicos/fisiológicos; c limites de controle do comportamento por eventos internos/fisiológicos; d comportamento privado como comportamento do organismo como um todo; e distinção entre contato privilegiado e conhecimento privilegiado; e f preservação do recorte analítico-comportamental em situação de análise aplicada do comportamento. As proposições correspondentes às categorias descritas são apontadas como originais na definição do campo de uma ciência do comportamento e capazes de orientar coerentemente a demarcação das fronteiras entre análise do comportamento e fisiologia enquanto disciplinas independentes e complementares.This study examines B. F. Skinner´s references to physiology in publications dealing with private events, in order to identify elements for a clearer definition of the relations between behavior analysis and physiology. Skinner´s contributions were analyzed with reference to six thematic categories: a biological variables as constitutive, albeit non-defining properties of private behavioral phenomena; b the autonomous nature of the behavioral-analytical approach in the face of biological/physiological facts; c limits of behavior control by internal/physiological events; d private behavior as behavior of the organism as a whole; e a distinction between privileged access and privileged knowledge; f retention of the behavioral-analytical approach in applied behavior analysis. Skinner´s propositions concerning the

  10. Sexual Identity, Sex of Sexual Contacts, and Health-Risk Behaviors among Students in Grades 9-12--Youth Risk Behavior Surveillance, Selected Sites, United States, 2001-2009. Morbidity and Mortality Weekly Report. Early Release. Volume 60

    Science.gov (United States)

    Kann, Laura; O'Malley Olsen, Emily; McManus, Tim; Kinchen, Steve; Chyen, David; Harris, William A.; Wechsler, Howell

    2011-01-01

    Problem: Sexual minority youths are youths who identify themselves as gay or lesbian, bisexual, or unsure of their sexual identity or youths who have only had sexual contact with persons of the same sex or with both sexes. Population-based data on the health-risk behaviors practiced by sexual minority youths are needed at the state and local…

  11. Riola release report

    Energy Technology Data Exchange (ETDEWEB)

    Woodward, E.C.

    1983-08-04

    Eleven hours after execution of the Riola Event (at 0826 PDT on 25 September 1980) in hole U2eq of the Nevada Test Site (NTS), a release of radioactivity began. When the seepage stopped at about noon the following day, up to some 3200 Ci of activity had been dispersed by light variable winds. On 26 September, examination of the geophone records showed six hours of low-level, but fairly continuous, activity before the release. Electrical measurements indicated that most cables were still intact to a depth below the stemming platform. A survey of the ground zero area showed that the seepage came through cracks between the surface conductor and the pad, through cracks in the pad, and through a crack adjacent to the pad around the mousehole (a small hole adjacent to the emplacement hole). To preclude undue radiation exposure or injury from a surprise subsidence, safety measures were instituted. Tritium seepage was suffucient to postpone site activities until a box and pipeline were emplaced to contain and remove the gas. Radiation release modeling and calculations were generally consistent with observations. Plug-hole interaction calculations showed that the alluvium near the bottom of the plug may have been overstressed and that improvements in the design of the plug-medium interface can be made. Experimental studies verified that the surface appearance of the plug core was caused by erosion, but, assuming a normal strength for the plug material, that erosion alone could not account for the disappearance of such a large portion of the stemming platform. Samples from downhole plug experiments show that the plug may have been considerably weaker than had been indicted by quality assurance (QA) samples. 19 references, 32 figures, 10 tables.

  12. Riola release report

    International Nuclear Information System (INIS)

    Woodward, E.C.

    1983-01-01

    Eleven hours after execution of the Riola Event (at 0826 PDT on 25 September 1980) in hole U2eq of the Nevada Test Site (NTS), a release of radioactivity began. When the seepage stopped at about noon the following day, up to some 3200 Ci of activity had been dispersed by light variable winds. On 26 September, examination of the geophone records showed six hours of low-level, but fairly continuous, activity before the release. Electrical measurements indicated that most cables were still intact to a depth below the stemming platform. A survey of the ground zero area showed that the seepage came through cracks between the surface conductor and the pad, through cracks in the pad, and through a crack adjacent to the pad around the mousehole (a small hole adjacent to the emplacement hole). To preclude undue radiation exposure or injury from a surprise subsidence, safety measures were instituted. Tritium seepage was suffucient to postpone site activities until a box and pipeline were emplaced to contain and remove the gas. Radiation release modeling and calculations were generally consistent with observations. Plug-hole interaction calculations showed that the alluvium near the bottom of the plug may have been overstressed and that improvements in the design of the plug-medium interface can be made. Experimental studies verified that the surface appearance of the plug core was caused by erosion, but, assuming a normal strength for the plug material, that erosion alone could not account for the disappearance of such a large portion of the stemming platform. Samples from downhole plug experiments show that the plug may have been considerably weaker than had been indicted by quality assurance (QA) samples. 19 references, 32 figures, 10 tables

  13. How Do We Choose among Strategies to Accomplish Cognitive Tasks? Evidence from Behavioral and Event-Related Potential Data in Arithmetic Problem Solving

    Science.gov (United States)

    Taillan, Julien; Dufau, Stéphane; Lemaire, Patrick

    2015-01-01

    We used event-related potentials (ERPs) to determine the time course of mechanisms underlying strategy selection. Participants had to select the better strategy on multiplication problems (i.e., 51 × 27) to find approximate products. They could choose between rounding up and rounding down both operands to their nearest decades. Two types of…

  14. Multi-day activity scheduling reactions to planned activities and future events in a dynamic model of activity-travel behavior

    NARCIS (Netherlands)

    Nijland, L.; Arentze, T.A.; Timmermans, H.J.P.

    2014-01-01

    Modeling multi-day planning has received scarce attention in activity-based transport demand modeling so far. However, new dynamic activity-based approaches are being developed at the current moment. The frequency and inflexibility of planned activities and events in activity schedules of

  15. Multi-Day Activity Scheduling Reactions to Planned Activities and Future Events in a Dynamic Model of Activity-Travel Behavior

    NARCIS (Netherlands)

    Nijland, L.; Arentze, T.; Timmermans, H.

    2014-01-01

    Modeling multi-day planning has received scarce attention in activity-based transport demand modeling so far. However, new dynamic activity-based approaches are being developed at the current moment. The frequency and inflexibility of planned activities and events in activity schedules of

  16. Relationships between Event-Related Potentials and Behavioral and Scholastic Measures of Reading Ability: A Large-Scale, Cross-Sectional Study

    Science.gov (United States)

    Khalifian, Negin; Stites, Mallory C.; Laszlo, Sarah

    2016-01-01

    In the cognitive, computational, neuropsychological, and educational literatures, it is established that children approach text in unique ways, and that even adult readers can differ in the strategies they bring to reading. In the developmental event-related potential (ERP) literature, however, children with differing degrees of reading ability…

  17. Multi-day activity scheduling reactions to planned activities and future events in a dynamic agent-based model of activity-travel behavior

    NARCIS (Netherlands)

    Nijland, E.W.L.; Arentze, T.A.; Timmermans, H.J.P.

    2009-01-01

    Modeling multi-day planning has received scarce attention today in activity-based transport demand modeling. Elaborating and combining previous work on event-driven activity generation, the aim of this paper is to develop and illustrate an extension of a need-based model of activity generation that

  18. Cumulative release to the accessible environment

    International Nuclear Information System (INIS)

    Kanehiro, B.

    1985-01-01

    The Containment and Isolation Working Group considered issues related to the postclosure behavior of repositories in crystalline rock. This working group was further divided into subgroups to consider the progress since the 1978 GAIN Symposium and identify research needs in the individual areas of regional ground-water flow, ground-water travel time, fractional release, and cumulative release. The analysis and findings of the Fractional Release Subgroup are presented

  19. Nuclear reactor fuel rod behavior modelling and current trends

    International Nuclear Information System (INIS)

    Colak, Ue.

    2001-01-01

    Safety assessment of nuclear reactors is carried out by simulating the events to taking place in nuclear reactors by realistic computer codes. Such codes are developed in a way that each event is represented by differential equations derived based on physical laws. Nuclear fuel is an important barrier against radioactive fission gas release. The release of radioactivity to environment is the main concern and this can be avoided by preserving the integrity of fuel rod. Therefore, safety analyses should cover an assessment of fuel rod behavior with certain extent. In this study, common approaches for fuel behavior modeling are discussed. Methods utilized by widely accepted computer codes are reviewed. Shortcomings of these methods are explained. Current research topics to improve code reliability and problems encountered in fuel rod behavior modeling are presented

  20. News/Press Releases

    Data.gov (United States)

    Office of Personnel Management — A press release, news release, media release, press statement is written communication directed at members of the news media for the purpose of announcing programs...

  1. A hierarchical stress release model for synthetic seismicity

    Science.gov (United States)

    Bebbington, Mark

    1997-06-01

    We construct a stochastic dynamic model for synthetic seismicity involving stochastic stress input, release, and transfer in an environment of heterogeneous strength and interacting segments. The model is not fault-specific, having a number of adjustable parameters with physical interpretation, namely, stress relaxation, stress transfer, stress dissipation, segment structure, strength, and strength heterogeneity, which affect the seismicity in various ways. Local parameters are chosen to be consistent with large historical events, other parameters to reproduce bulk seismicity statistics for the fault as a whole. The one-dimensional fault is divided into a number of segments, each comprising a varying number of nodes. Stress input occurs at each node in a simple random process, representing the slow buildup due to tectonic plate movements. Events are initiated, subject to a stochastic hazard function, when the stress on a node exceeds the local strength. An event begins with the transfer of excess stress to neighboring nodes, which may in turn transfer their excess stress to the next neighbor. If the event grows to include the entire segment, then most of the stress on the segment is transferred to neighboring segments (or dissipated) in a characteristic event. These large events may themselves spread to other segments. We use the Middle America Trench to demonstrate that this model, using simple stochastic stress input and triggering mechanisms, can produce behavior consistent with the historical record over five units of magnitude. We also investigate the effects of perturbing various parameters in order to show how the model might be tailored to a specific fault structure. The strength of the model lies in this ability to reproduce the behavior of a general linear fault system through the choice of a relatively small number of parameters. It remains to develop a procedure for estimating the internal state of the model from the historical observations in order to

  2. Learning and Behavior

    Science.gov (United States)

    ... List About PPMD Events News Login By Area Learning & Behavior Attention, Listening & Learning Autism Spectrum Disorder (ASD) ... Care Guidelines ❯ By Area ❯ Learning & Behavior Share Print Learning & Behavior Facts to Remember People with Duchenne may ...

  3. Why didn’t you say something? Using after-event reviews to affect voice behavior and hierarchy beliefs in multi-professional action teams

    OpenAIRE

    Weiss Mona; Kolbe Michaela; Grote Gudela; Spahn Donat R.; Grande Bastian

    2016-01-01

    Team decision making can go wrong when individuals fear to voice suggestions or concerns to higher status team members. We investigate how after event reviews (AERs) can be used to promote voice behaviour and hierarchy attenuating beliefs in multi professional action teams. We hypothesized that (1) lower status team members will speak up more following an assertiveness specific AER (ASAER) as compared to a teamwork generic AER (TGAER) and (2) that an ASAER leads to stronger endorsement of hie...

  4. Multi-day activity scheduling reactions to planned activities and future events in a dynamic model of activity-travel behavior

    Science.gov (United States)

    Nijland, Linda; Arentze, Theo; Timmermans, Harry

    2014-01-01

    Modeling multi-day planning has received scarce attention in activity-based transport demand modeling so far. However, new dynamic activity-based approaches are being developed at the current moment. The frequency and inflexibility of planned activities and events in activity schedules of individuals indicate the importance of incorporating those pre-planned activities in the new generation of dynamic travel demand models. Elaborating and combining previous work on event-driven activity generation, the aim of this paper is to develop and illustrate an extension of a need-based model of activity generation that takes into account possible influences of pre-planned activities and events. This paper describes the theory and shows the results of simulations of the extension. The simulation was conducted for six different activities, and the parameter values used were consistent with an earlier estimation study. The results show that the model works well and that the influences of the parameters are consistent, logical, and have clear interpretations. These findings offer further evidence of face and construct validity to the suggested modeling approach.

  5. Fusion events

    International Nuclear Information System (INIS)

    Aboufirassi, M; Angelique, J.C.; Bizard, G.; Bougault, R.; Brou, R.; Buta, A.; Colin, J.; Cussol, D.; Durand, D.; Genoux-Lubain, A.; Horn, D.; Kerambrun, A.; Laville, J.L.; Le Brun, C.; Lecolley, J.F.; Lefebvres, F.; Lopez, O.; Louvel, M.; Meslin, C.; Metivier, V.; Nakagawa, T.; Peter, J.; Popescu, R.; Regimbart, R.; Steckmeyer, J.C.; Tamain, B.; Vient, E.; Wieloch, A.; Yuasa-Nakagawa, K.

    1998-01-01

    The fusion reactions between low energy heavy ions have a very high cross section. First measurements at energies around 30-40 MeV/nucleon indicated no residue of either complete or incomplete fusion, thus demonstrating the disappearance of this process. This is explained as being due to the high amount o energies transferred to the nucleus, what leads to its total dislocation in light fragments and particles. Exclusive analyses have permitted to mark clearly the presence of fusion processes in heavy systems at energies above 30-40 MeV/nucleon. Among the complete events of the Kr + Au reaction at 60 MeV/nucleon the majority correspond to binary collisions. Nevertheless, for the most considerable energy losses, a class of events do occur for which the detected fragments appears to be emitted from a unique source. These events correspond to an incomplete projectile-target fusion followed by a multifragmentation. Such events were singled out also in the reaction Xe + Sn at 50 MeV/nucleon. For the events in which the energy dissipation was maximal it was possible to isolate an isotropic group of events showing all the characteristics of fusion nuclei. The fusion is said to be incomplete as pre-equilibrium Z = 1 and Z = 2 particles are emitted. The cross section is of the order of 25 mb. Similar conclusions were drown for the systems 36 Ar + 27 Al and 64 Zn + nat Ti. A cross section value of ∼ 20 mb was determined at 55 MeV/nucleon in the first case, while the measurement of evaporation light residues in the last system gave an upper limit of 20-30 mb for the cross section at 50 MeV/nucleon

  6. Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior.

    Science.gov (United States)

    Zuo, Dai-Ying; Zhang, Ya-Hong; Cao, Yue; Wu, Chun-Fu; Tanaka, Masatoshi; Wu, Ying-Liang

    2006-04-04

    The present study was designed to investigate the effects of acute and chronic administration of MK-801 (0.6 mg/kg), a noncompetitive NMDA-receptor antagonist on extracellular glutamate (Glu) and ascorbic acid (AA) release in the prefrontal cortex (PFC) of freely moving mice using in vivo microdialysis with open-field behavior. In line with earlier studies, acute administration of MK-801 induced an increase of Glu in the PFC. We also observed single MK-801 treatment increased AA release in the PFC. In addition, our results indicated that the basal AA levels in the PFC after MK-801 administration for 7 consecutive days were significantly decreased, and basal Glu levels also had a decreased tendency. After chronic administration (0.6 mg/kg, 7 days), MK-801 (0.6 mg/kg) challenge significantly decreased dialysate levels of AA and Glu. Our study also found that both acute and chronic administration of MK-801 induced hyperactivity in mice, but the intensity of acute administration was more than that of chronic administration. Furthermore, in all acute treatment mice, individual changes in Glu dialysate concentrations and the numbers of locomotion were positively correlated. In conclusion, this study may provide new evidence that a single MK-801 administration induces increases of dialysate AA and Glu concentrations in the PFC of freely moving mice, which are opposite to those induced by repeated MK-801 administration, with an unknown mechanism. Our results suggested that redox-response might play an important role in the model of schizophrenic symptoms induced by MK-801.

  7. Tritium sorption by cement and subsequent release

    International Nuclear Information System (INIS)

    Ono, F.; Tanaka, S.; Yamawaki, M.

    1994-01-01

    In a fusion reactor or tritium handling facilities, contamination of concrete by tritium and subsequent release from it to the reactor or experimental rooms is a matter of problem for safety control of tritium and management of operational environment. In order to evaluate these tritium behavior, interaction of tritiated water with concrete or cement should be clarified. In the present study, HTO sorption and subsequent release from cement were studied by combining various experimental methods. From the basic studies on tritium-cement interactions, it has become possible to evaluate tritium uptake by cement or concrete and subsequent tritium release behavior as well as tritium removing methods from them

  8. Fuel morphology effects on fission product release

    International Nuclear Information System (INIS)

    Osetek, D.J.; Hartwell, J.K.; Cronenberg, A.W.

    1986-01-01

    Results are presented of fission product release behavior observed during four severe fuel damage tests on bundles of UO 2 fuel rods. Transient temperatures up to fuel melting were obtained in the tests that included both rapid and slow cooldown, low and high (36 GWd/t) burnup fuel and the addition of Ag-In-Cd control rods. Release fractions of major fission product species and release rates of noble gas species are reported. Significant differences in release behavior are discussed between heatup and cooldown periods, low and high burnup fuel and long- and short-lived fission products. Explanations for the observed differences are offered that relate fuel morphology changes to the releases

  9. Discrete-Event Simulation

    Directory of Open Access Journals (Sweden)

    Prateek Sharma

    2015-04-01

    Full Text Available Abstract Simulation can be regarded as the emulation of the behavior of a real-world system over an interval of time. The process of simulation relies upon the generation of the history of a system and then analyzing that history to predict the outcome and improve the working of real systems. Simulations can be of various kinds but the topic of interest here is one of the most important kind of simulation which is Discrete-Event Simulation which models the system as a discrete sequence of events in time. So this paper aims at introducing about Discrete-Event Simulation and analyzing how it is beneficial to the real world systems.

  10. Enterprising Behavior: Meta-Analysis of Articles Published in Enanpad Between 2004 And 2008, studying of National Event and The Influence of International Production.

    Directory of Open Access Journals (Sweden)

    Indiara Beltrame Brancher

    2012-07-01

    Full Text Available It has been possible to realize the significant contribution of entrepreneurs to the economy, given its ability to create jobs, provide new products, as well as establishing networks of small businesses. This can be verified in the importance given to the study of entrepreneurship worldwide. Evidence of this is the Global Entrepreneurship Monitor (GEM project, which booted in 1999, a partnership with London Business School and Babson College - UK, initially considered ten countries and now are 85 (GEM, 2012. We can realize the growing interest on the subject in academic environmentalist. In order to undertake the study of behavior has been gaining momentum. Many authors describe the Enterprising as individuals who have specific characteristics that differentiate them from others. In addition there has been increasing interest in entrepreneurship, a topic that has been gaining attention in the literature, reflected in the increasing number of publications on the subject. With the U.S., this paper aims to develop a meta-analysis of articles published in EnANPAD on entrepreneurial behavior in the period between 2004 and 2008, and identify the influence of international podução. Looking from this, to review the issue in order to present a theoretical map of the paths which Brazilian researchers have followed in the search for understanding of the topic, as well as identify possible inflência international publications in the national production on the subject. Theoretical framework can highlight Dornelas (2001, Gimenez (et. al 2008, Schumpeter (1982, McClelland (1972 and Filion (1999. The results showed a predominance of the approach the subject from the behavioral characteristics of the entrepreneur, the majority of authors coming from institutions in the south and southeastern Brazil, and more totalized by the same methodology in the development of the work was theoretical-empirical. Was significant, the finding also influence the production

  11. A Comparative Study on Micellar and Solubilizing Behavior of Three EO-PO Based Star Block Copolymers Varying in Hydrophobicity and Their Application for the In Vitro Release of Anticancer Drugs

    Directory of Open Access Journals (Sweden)

    Bijal Vyas

    2018-01-01

    Full Text Available The temperature and pH dependent self-assembly of three star shaped ethylene oxide-propylene oxide (EO-PO block copolymers (Tetronics® 304, 904 and 908 with widely different hydrophobicity was examined in aqueous solutions. Physico-chemical methods viz. viscosity, cloud point, solubilization along with thermal, scattering and spectral techniques shows strongly temperature and salt dependent solution behavior. T304 possessing low molecular weight did not form micelles; moderately hydrophilic T904 remained as micelles at ambient temperature and showed micellar growth while very hydrophilic T908 formed micelles at elevated temperatures. The surface activity/micellization/solubilization power was favored in the presence of salt. The copolymers turn more hydrophilic in acidic pH due to protonation of central ethylene diamine moiety that hinders micelle formation. The solubilization of a model insoluble azo dye 1-(o-Tolylazo-2-naphthol (Orange OT and hydrophobic drugs (quercetin and curcumin for copolymer solutions in aqueous and salt solutions are also reported. Among the three copolymers, T904 showed maximum solubility of dye and drugs, hence the in vitro release of drugs from T904 micelles was estimated and the effect on cytotoxicity of loading the drugs in T904 micelles was compared with the cytotoxicity of free drugs on the CHO-K1 cells. The results from the present work provide a better insight in selection of Tetronics® for their application in different therapeutic applications.

  12. The Role of Difficulty in Identifying and Describing Feelings in Non-Suicidal Self-Injury Behavior (NSSI): Associations With Perceived Attachment Quality, Stressful Life Events, and Suicidal Ideation.

    Science.gov (United States)

    Cerutti, Rita; Zuffianò, Antonio; Spensieri, Valentina

    2018-01-01

    Objective: Core alexithymic features, such as the difficulty in identifying and describing feelings, are associated with poor attachment styles and emotional trauma, which influence the capacity to regulate affect. Additionally, emotional regulation has been found to be the most commonly identified function associated with non-suicidal self-injury behavior (NSSI) in adolescents as they attempt to modulate strong emotions. However, few studies have examined the link between difficulty in identifying and describing feelings (core components of alexithymia), NSSI behaviors, quality of attachment, life stressors and suicidal ideation in healthy early adolescents. Consequently, this study aims to investigate these constructs and the relationship among them in a large non-clinical sample of adolescents. Methods: Seven hundred and nine middle school students (50.4% males), aged 10-15 years ( M = 12.6; SD = 1.06) were involved in this study. In order to investigate the variables considered in the study, the following measures were administered: the Deliberate Self-Harm Inventory exploring non-suicidal self-injurious behaviors; the Alexithymia Questionnaire for Children examining difficulty in identifying and describing feelings; the Inventory of Parent and Peer Attachment assessing the quality of parental and peer attachment; the Life Stressor Checklist-Revised outlining stressful/traumatic events and the Children's Depression Inventory evaluating suicidal ideation. Results: We found significantly positive relationships among difficulty in identifying and describing feelings, NSSI behaviors, stressful events, and suicidal ideation. Data indicated a significant negative association of difficulty in identifying and describing feelings with quality of attachment to parents and peers. Further findings highlighted that difficulty in identifying and describing feelings significantly mediated the effect of quality of attachment (parent and peer) on NSSI and suicidal ideation

  13. Release of silver nanoparticles from outdoor facades

    International Nuclear Information System (INIS)

    Kaegi, Ralf; Sinnet, Brian; Zuleeg, Steffen; Hagendorfer, Harald; Mueller, Elisabeth; Vonbank, Roger; Boller, Markus; Burkhardt, Michael

    2010-01-01

    In this study we investigate the release of metallic silver nanoparticles (Ag-NP) from paints used for outdoor applications. A facade panel mounted on a model house was exposed to ambient weather conditions over a period of one year. The runoff volume of individual rain events was determined and the silver and titanium concentrations of 36 out of 65 runoff events were measured. Selected samples were prepared for electron microscopic analysis. A strong leaching of the Ag-NP was observed during the initial runoff events with a maximum concentration of 145 μ Ag/l. After a period of one year, more than 30% of the Ag-NP were released to the environment. Particles were mostly 2 S. - We provide direct evidence for the release of silver nanoparticles from exterior paints to the aquatic environment.

  14. Amphetamine Paradoxically Augments Exocytotic Dopamine Release and Phasic Dopamine Signals

    Science.gov (United States)

    Daberkow, DP; Brown, HD; Bunner, KD; Kraniotis, SA; Doellman, MA; Ragozzino, ME; Garris, PA; Roitman, MF

    2013-01-01

    Drugs of abuse hijack brain reward circuitry during the addiction process by augmenting action potential-dependent phasic dopamine release events associated with learning and goal-directed behavior. One prominent exception to this notion would appear to be amphetamine (AMPH) and related analogs, which are proposed instead to disrupt normal patterns of dopamine neurotransmission by depleting vesicular stores and promoting non-exocytotic dopamine efflux via reverse transport. This mechanism of AMPH action, though, is inconsistent with its therapeutic effects and addictive properties - which are thought to be reliant on phasic dopamine signaling. Here we used fast-scan cyclic voltammetry in freely moving rats to interrogate principal neurochemical responses to AMPH in the striatum and relate these changes to behavior. First, we showed that AMPH dose-dependently enhanced evoked dopamine responses to phasic-like current pulse trains for up to two hours. Modeling the data revealed that AMPH inhibited dopamine uptake but also unexpectedly potentiated vesicular dopamine release. Second, we found that AMPH increased the amplitude, duration and frequency of spontaneous dopamine transients, the naturally occurring, non-electrically evoked, phasic increases in extracellular dopamine. Finally, using an operant sucrose reward paradigm, we showed that low-dose AMPH augmented dopamine transients elicited by sucrose-predictive cues. However, operant behavior failed at high-dose AMPH, which was due to phasic dopamine hyperactivity and the decoupling of dopamine transients from the reward predictive cue. These findings identify up-regulation of exocytotic dopamine release as a key AMPH action in behaving animals and support a unified mechanism of abused drugs to activate phasic dopamine signaling. PMID:23303926

  15. Event-related brain potentials, bilateral electrodermal activity and Mangina-Test performance in learning disabled/ADHD pre-adolescents with severe behavioral disorders as compared to age-matched normal controls.

    Science.gov (United States)

    Mangina, C A; Beuzeron-Mangina, J H; Grizenko, N

    2000-07-01

    The most frequently encountered developmental problems of learning disabilities/ADHD often co-exist with severe behavioral disorders. As a direct consequence, this condition opens the way to delinquency, school drop-out, depression, suicide, substance abuse, work absenteeism, and other psycho-social complications. In this paper, we are presenting a selective overview of our previous research and its clinical applications in this field as it relates to our present research data pertaining to the effects of our original Memory Workload Paradigm on the event-related brain potentials in differentiating normal and pathological pre-adolescents (learning disabled/ADHD with concomitant severe behavioral disorders such as oppositional and conduct). In addition, it provides data on the bilateral electrodermal activity during cognitive workload and Mangina-Test performance of pathological and normal pre-adolescents conducted in separate sessions. The results of our present research indicate that a significant memory load effect for the P450 latency (F(3,27)=4.98, PWorkload Paradigm in pre-frontal and frontal regions clearly differentiated normal from pathological pre-adolescents (F(1, 18)=12.21, Presearch findings provide an original and valuable demonstration of an integrative and effective clinical psychophysiological application of central (ERPs), autonomic (bilateral electrodermal activity) and neuro-psychometric aspects (Mangina-Test) which characterize normal and pathological pre-adolescents and underpin the neurophysiological basis of learning disabled/ADHD with severe behavioral disorders as opposed to normal subjects.

  16. Depressive Symptoms and Risk of New Cardiovascular Events or Death in Patients with Myocardial Infarction: A Population-Based Longitudinal Study Examining Health Behaviors and Health Care Interventions

    DEFF Research Database (Denmark)

    Larsen, Karen Kjær; Christensen, Bo; Søndergaard, Jens

    2013-01-01

    Mange mennesker rammes af depression efter en blodprop i hjertet (AMI), og denne kombination er forbundet med en dårligere prognose. Dette studie er det første, der viser, at depression udgør en selv-stændig risikofaktor for tidlig død hos patienter med blodprop i hjertet. Undersøgelsen tyder dog...... bruges til at skærpe opmærksomheden over for denne patientgruppe hos de praktiserende læger, hvor op mod 90 % af alle patienter med depression bliver diagnosticeret og behandlet. Background: Depressive symptoms is associated with adverse cardiovascular outcomes in patients with myocardial infarction (MI......), but the underlying mechanisms are unclear and it remains unknown whether subgroups of patients are at a particularly high relative risk of adverse outcomes. We examined the risk of new cardiovascular events and/or death in patients with depressive symptoms following first-time MI taking into account other secondary...

  17. Two Aspects of Activation: Arousal and Subjective Significance – Behavioral and Event-Related Potential Correlates Investigated by Means of a Modified Emotional Stroop Task

    Directory of Open Access Journals (Sweden)

    Kamil Imbir

    2017-12-01

    Full Text Available The arousal level of words presented in a Stroop task was found to affect their interference on the required naming of the words’ color. Based on a dual-processes approach, we propose that there are two aspects to activation: arousal and subjective significance. Arousal is crucial for automatic processing. Subjective significance is specific to controlled processing. Based on this conceptual model, we predicted that arousal would enhance interference in a Stroop task, as attention would be allocated to the meaning of the inhibited word. High subjective significance should have the opposite effect, i.e., it should enhance the controlled and explicit part of Stroop task processing, which is color naming. We found that response latencies were modulated by the interaction between the arousal and subjective significance levels of words. The longest reaction times were observed for highly arousing words of medium subjective significance level. Arousal shaped event related potentials in the 150–290 ms time range, while effects of subjective significance were found for 50–150, 150–290, and 290–530 ms time ranges.

  18. Controlling hydrogen behavior in light water reactors

    International Nuclear Information System (INIS)

    Cullingford, H.S.; Edeskuty, F.J.

    1981-01-01

    In the aftermath of the incident at Three Mile Island Unit 2 (TMI-2), a new and different treatment of the Light Water Reactor (LWR) risks is needed for public safety because of the specific events involving hydrogen generation, transport, and behavior following the core damage. Hydrogen behavior in closed environments such as the TMI-2 containment building is a complex phenomenon that is not fully understood. Hence, an engineering approach is presented for prevention of loss of life, equipment, and environment in case of a large hydrogen generation in an LWR. A six-level defense strategy is described that minimizes the possibility of ignition of released hydrogen gas and otherwise mitigates the consequences of hydrogen release. Guidance is given to reactor manufacturers, utility companies, regulatory agencies, and research organizations committed to reducing risk factors and insuring safety of life, equipment, and environment

  19. Event Index - a LHCb Event Search System

    CERN Document Server

    INSPIRE-00392208; Kazeev, Nikita; Redkin, Artem

    2015-12-23

    LHC experiments generate up to $10^{12}$ events per year. This paper describes Event Index - an event search system. Event Index's primary function is quickly selecting subsets of events from a combination of conditions, such as the estimated decay channel or stripping lines output. Event Index is essentially Apache Lucene optimized for read-only indexes distributed over independent shards on independent nodes.

  20. Toxics Release Inventory (TRI)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Toxics Release Inventory (TRI) is a dataset compiled by the U.S. Environmental Protection Agency (EPA). It contains information on the release and waste...

  1. Perceiving Event Dynamics and Parsing Hollywood Films

    Science.gov (United States)

    Cutting, James E.; Brunick, Kaitlin L.; Candan, Ayse

    2012-01-01

    We selected 24 Hollywood movies released from 1940 through 2010 to serve as a film corpus. Eight viewers, three per film, parsed them into events, which are best termed subscenes. While watching a film a second time, viewers scrolled through frames and recorded the frame number where each event began. Viewers agreed about 90% of the time. We then…

  2. Thermal shock behavior of W-ZrC/Sc2O3 composites under two different transient events by electron and laser irradiation

    Science.gov (United States)

    Chen, Hong-Yu; Luo, Lai-Ma; Zan, Xiang; Xu, Qiu; Tokunaga, Kazutoshi; Liu, Jia-Qin; Zhu, Xiao-Yong; Cheng, Ji-Gui; Wu, Yu-Cheng

    2018-02-01

    The transient thermal shock behaviors of W-ZrC/Sc2O3 composites with different ZrC contents were evaluated using transient thermal shock test by electron and laser beams. The effects of different ZrC doping contents on the surface morphology and thermal shock resistance of W-ZrC/Sc2O3 composites were then investigated. Similarity and difference between effects of electron and laser beam transient heat loading were also discussed in this study. Repeated heat loading resulted in thermal fatigue of the irradiated W-ZrC/Sc2O3 samples by thermal stress, leading to the rough surface morphologies with cracks. After different transient thermal tests, significant surface roughening, cracks, surface melting, and droplet ejection occurred. W-2vol.%Sc2O3 sample has superior thermal properties and greater resistance to surface modifications under transient thermal shock, and with the increasing ZrC content in W alloys, thermal shock resistance of W-Zr/Sc2O3 sample tends to be unsatisfied.

  3. Simulating events

    Energy Technology Data Exchange (ETDEWEB)

    Ferretti, C; Bruzzone, L [Techint Italimpianti, Milan (Italy)

    2000-06-01

    The Petacalco Marine terminal on the Pacific coast in the harbour of Lazaro Carclenas (Michoacan) in Mexico, provides coal to the thermoelectric power plant at Pdte Plutarco Elias Calles in the port area. The plant is being converted from oil to burn coal to generate 2100 MW of power. The article describes the layout of the terminal and equipment employed in the unloading, coal stacking, coal handling areas and the receiving area at the power plant. The contractor Techint Italimpianti has developed a software system, MHATIS, for marine terminal management which is nearly complete. The discrete event simulator with its graphic interface provides a real-type decision support system for simulating changes to the terminal operations and evaluating impacts. The article describes how MHATIS is used. 7 figs.

  4. Event generators

    International Nuclear Information System (INIS)

    Durand, D.; Gulminelli, F.; Lopez, O.; Vient, E.

    1998-01-01

    The results concerning the heavy ion collision simulations at Fermi energies by means of phenomenological models obtained in the last two years ar presented. The event generators are essentially following the phase of elaboration of analysis methods of data obtained by INDRA or NAUTILUS 4 π multidetectors. To identify and correctly quantify a phenomenon or a physical quantity it is necessary to verify by simulation the feasibility and validity of the analysis and also to estimate the bias introduced by the experimental filter. Many studies have shown this, for instance: the determination of the collision reaction plan for flow studies, determination of kinematical characteristics of the quasi-projectiles, and the excitation energy measurement stored in the hot nuclei. To Eugene, the currently utilised generator, several improvements were added: introduction of space-time correlations between the different products emitted in the decay of excited nuclei by calculating the trajectories of the particles in the final phase of the reaction; taking into account in the decay cascade of the discrete levels of the lighter fragments; the possibility of the schematically description of the explosion of the nucleus by simultaneous emission of multi-fragments. Thus, by comparing the calculations with the data relative to heavy systems studied with the NAUTILUS assembly it was possible to extract the time scales in the nuclear fragmentation. The utilisation of these event generators was extended to the analysis of INDRA data concerning the determination of the vaporization threshold in the collisions Ar + Ni and also the research of the expansion effects in the collisions Xe + Sn at 50 MeV/u

  5. Recent geological events and intrinsic behavior influence the population genetic structure of the chiru and tibetan gazelle on the tibetan plateau.

    Science.gov (United States)

    Zhang, Fangfang; Jiang, Zhigang; Xu, Aichun; Zeng, Yan; Li, Chunwang

    2013-01-01

    The extent to which a species responds to environmental changes is mediated not only by extrinsic processes such as time and space, but also by species-specific ecology. The Qinghai-Tibetan Plateau uplifted approximately 3000 m and experienced at least four major glaciations during the Pleistocene epoch in the Quaternary Period. Consequently, the area experienced concurrent changes in geomorphological structure and climate. Two species, the Tibetan antelope (Pantholops hodgsonii, chiru) and Tibetan gazelle (Procapra picticaudata), both are endemic on the Qinghai-Tibetan Plateau, where their habitats overlap, but have different migratory behaviors: the chiru is inclined to have female-biased dispersal with a breeding migration during the calving season; in contrast, Tibetan gazelles are year-round residents and never migrate distantly. By using coalescence methods we compared mitochondrial control region DNA sequences and variation at nine microsatellite loci in these two species. Coalescent simulations indicate that the chiru and Tibetan gazelle do not share concordant patterns in their genealogies. The non-migratory Tibetan gazelle, that is more vulnerable to the impact of drastic geographic changes such as the elevation of the plateau, glaciations and so on, appears to have a strong population genetic structure with complicated demographic history. Specifically, the Tibetan gazelle population appears to have experienced isolation and divergence with population fluctuations since the Middle Pleistocene (0.781 Ma). However, it showed continued decline since the Upper Pleistocene (0.126 Ma), which may be attributed to the irreversible impact of increased human activities on the plateau. In contrast, the migratory chiru appears to have simply experienced population expansion. With substantial gene flow among regional populations, this species shows no historical population isolation and divergence. Thus, this study adds to many empirical studies that show historical

  6. Events diary

    Science.gov (United States)

    2000-01-01

    as Imperial College, the Royal Albert Hall, the Royal College of Art, the Natural History and Science Museums and the Royal Geographical Society. Under the heading `Shaping the future together' BA2000 will explore science, engineering and technology in their wider cultural context. Further information about this event on 6 - 12 September may be obtained from Sandra Koura, BA2000 Festival Manager, British Association for the Advancement of Science, 23 Savile Row, London W1X 2NB (tel: 0171 973 3075, e-mail: sandra.koura@britassoc.org.uk ). Details of the creating SPARKS events may be obtained from creating.sparks@britassoc.org.uk or from the website www.britassoc.org.uk . Other events 3 - 7 July, Porto Alegre, Brazil VII Interamerican conference on physics education: The preparation of physicists and physics teachers in contemporary society. Info: IACPE7@if.ufrgs.br or cabbat1.cnea.gov.ar/iacpe/iacpei.htm 27 August - 1 September, Barcelona, Spain GIREP conference: Physics teacher education beyond 2000. Info: www.blues.uab.es/phyteb/index.html

  7. Geophysical events

    Science.gov (United States)

    This is a summary of SEAN Bulletin, 13(3), March 31, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-002 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $1. Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid.

  8. Towards a unified study of extreme events using universality concepts and transdisciplinary analysis methods

    Science.gov (United States)

    Balasis, George; Donner, Reik V.; Donges, Jonathan F.; Radebach, Alexander; Eftaxias, Konstantinos; Kurths, Jürgen

    2013-04-01

    The dynamics of many complex systems is characterized by the same universal principles. In particular, systems which are otherwise quite different in nature show striking similarities in their behavior near tipping points (bifurcations, phase transitions, sudden regime shifts) and associated extreme events. Such critical phenomena are frequently found in diverse fields such as climate, seismology, or financial markets. Notably, the observed similarities include a high degree of organization, persistent behavior, and accelerated energy release, which are common to (among others) phenomena related to geomagnetic variability of the terrestrial magnetosphere (intense magnetic storms), seismic activity (electromagnetic emissions prior to earthquakes), solar-terrestrial physics (solar flares), neurophysiology (epileptic seizures), and socioeconomic systems (stock market crashes). It is an open question whether the spatial and temporal complexity associated with extreme events arises from the system's structural organization (geometry) or from the chaotic behavior inherent to the nonlinear equations governing the dynamics of these phenomena. On the one hand, the presence of scaling laws associated with earthquakes and geomagnetic disturbances suggests understanding these events as generalized phase transitions similar to nucleation and critical phenomena in thermal and magnetic systems. On the other hand, because of the structural organization of the systems (e.g., as complex networks) the associated spatial geometry and/or topology of interactions plays a fundamental role in the emergence of extreme events. Here, a few aspects of the interplay between geometry and dynamics (critical phase transitions) that could result in the emergence of extreme events, which is an open problem, will be discussed.

  9. Discrete-Event Simulation

    OpenAIRE

    Prateek Sharma

    2015-01-01

    Abstract Simulation can be regarded as the emulation of the behavior of a real-world system over an interval of time. The process of simulation relies upon the generation of the history of a system and then analyzing that history to predict the outcome and improve the working of real systems. Simulations can be of various kinds but the topic of interest here is one of the most important kind of simulation which is Discrete-Event Simulation which models the system as a discrete sequence of ev...

  10. Very low frequency earthquakes (VLFEs) detected during episodic tremor and slip (ETS) events in Cascadia using a match filter method indicate repeating events

    Science.gov (United States)

    Hutchison, A. A.; Ghosh, A.

    2016-12-01

    Very low frequency earthquakes (VLFEs) occur in transitional zones of faults, releasing seismic energy in the 0.02-0.05 Hz frequency band over a 90 s duration and typically have magntitudes within the range of Mw 3.0-4.0. VLFEs can occur down-dip of the seismogenic zone, where they can transfer stress up-dip potentially bringing the locked zone closer to a critical failure stress. VLFEs also occur up-dip of the seismogenic zone in a region along the plate interface that can rupture coseismically during large megathrust events, such as the 2011 Tohoku-Oki earthquake [Ide et al., 2011]. VLFEs were first detected in Cascadia during the 2011 episodic tremor and slip (ETS) event, occurring coincidentally with tremor [Ghosh et al., 2015]. However, during the 2014 ETS event, VLFEs were spatially and temporally asynchronous with tremor activity [Hutchison and Ghosh, 2016]. Such contrasting behaviors remind us that the mechanics behind such events remain elusive, yet they are responsible for the largest portion of the moment release during an ETS event. Here, we apply a match filter method using known VLFEs as template events to detect additional VLFEs. Using a grid-search centroid moment tensor inversion method, we invert stacks of the resulting match filter detections to ensure moment tensor solutions are similar to that of the respective template events. Our ability to successfully employ a match filter method to VLFE detection in Cascadia intrinsically indicates that these events can be repeating, implying that the same asperities are likely responsible for generating multiple VLFEs.

  11. Tritium sorption by cement and subsequent release

    International Nuclear Information System (INIS)

    Ono, F.; Yamawaki, M.

    1995-01-01

    In a fusion reactor or tritium-handling facilities, contamination of concrete by tritium and subsequent release from it to the reator or experimental room is a matter of problem for safe control of tritium and management of operational environment. In order to evaluate this tritium behavior, interaction of tritiated water with concrete or cement should be clarified. In the present study, HTO sorption and subsequent release from cement were experimentally studied.(1)Sorption experiments were conducted using columns packed with cement particles of different sizes. From the analysis of the breakthrough curve, tritium diffusivity in macropores and microparticles were evaluated.(2)From the short-term tritium release experiments, effective desorption rate constants were evaluated and the effects of temperature and moisture were studied.(3)In the long-term tritium release experiments to 6000h, the tritium release mechanism was found to be composed of three kinds of water: initially from capillary water, and in the second stage from gel water and from the water in the cement crystal.(4)Tritium release behavior by heat treatment to 800 C was studied. A high temperature above 600 C was required for the tritium trapped in the crystal water to be released. (orig.)

  12. Relations of alcohol-drinking behavior,social support and life events in college students%大学生饮酒行为与社会支持及生活事件的相关分析

    Institute of Scientific and Technical Information of China (English)

    周桂花; 汪萌芽

    2014-01-01

    Objective To investigate the current situation of alcohol-drinking behavior and its relations to the awareness of alcohol knowledge ,social support and life events of college students .Methods By using a conventional random sampling method ,559 college students from 9 faculties of 2 universities were involved in an anonymous survey including A Knowledge of Drinking Behavior of Adoles -cents Questionnaire, Social Support Rating Scale(SSRS),and Life Event Scale(LES).The relationship among drinking behavior and its impacting factors ,social support ,life events was analyzed by multivariate logistic regression .Results There were statistical differences in student drinking behavior in variables of gender (OR=4.51,P<0.001),living expenses per month (OR=1.67,P <0.001),physical exercises( OR=1.71,P<0.05)and awareness of alcohol-related knowledge(OR=1.99,P<0.001).There were also significant differ-ences in alcohol-related knowledge in variables of school (OR=0.62,P <0.01),the marriage status of parents(OR=1.53,P<0.05), teacher's discussion of drinking-related problems(OR=0 .65,P<0.05),alcohol-drinking behavior(OR=0.62,P<0.05),respectively. By using Two Independent -Samples T Test ,the relationship between social support and alcohol-drinking behavior of different faculty in college students was analyzed (t=3.99,P<0.001).Moreover,the Spearman rank correlation coefficient analyses presented a correlation of positive life event and objective support (r=0 .24,P <0.05)in non -drinking group,while the correlation between positive life event and subjective support(r=0.23, P<0.01)or social support(r=0.23,P<0.01),and a correlation of life event and social support (r=0.17,P<0.05)in alcohol-drinking group.Conclusion These preliminary results suggest that drinking behavior of college students is related to social support and life events ,and gender ,family environment and school environment are affecting factors as well .%目的:了解在校大学生饮酒行为及饮酒相关知识

  13. The influence of cladding on fission gas release from irradiated U-Mo monolithic fuel

    Energy Technology Data Exchange (ETDEWEB)

    Burkes, Douglas E., E-mail: Douglas.Burkes@pnnl.gov; Casella, Amanda J.; Casella, Andrew M.

    2017-04-01

    The monolithic uranium-molybdenum (U-Mo) alloy has been proposed as a fuel design capable of converting the world's highest power research reactors from use of high enriched uranium to low enriched uranium. However, a zirconium (Zr) diffusion barrier must be used to eliminate interactions that form between the U-Mo monolith and aluminum alloy 6061 (AA6061) cladding during fabrication and are enhanced during irradiation. One aspect of fuel development and qualification is to demonstrate an appropriate understanding of the extent of fission product release from the fuel under anticipated service environments. An exothermic reaction has previously been observed between the AA6061 cladding and Zr diffusion layer. In this paper, two fuel segments with different irradiation history were subjected to specified thermal profiles under a controlled atmosphere using a thermogravimetric/differential thermal analyzer coupled with a mass spectrometer inside a hot cell. Samples from each segment were tested with cladding and without cladding to investigate the effect, if any, that the exothermic reaction has on fission gas release mechanisms. Measurements revealed there is an instantaneous effect of the cladding/Zr exothermic reaction, but not necessarily a cumulative effect above approximately 973 K (700 °C). The mechanisms responsible for fission gas release events are discussed. - Highlights: •Complementary fission gas release events are reported for U-Mo fuel with and without cladding. •Exothermic reaction between Zr diffusion layer and cladding influences fission gas release. •Mechanisms responsible for fission gas release are similar, but with varying timing and magnitude. •Behavior of samples is similar after 800 °C signaling the onset of superlattice destabilization.

  14. Release to the environment and diffusion of radioiodine in the environment, 1

    International Nuclear Information System (INIS)

    Murata, Toshifumi

    1979-01-01

    1. Radioactivity of iodine nuclides accumulated in nuclear facilities. Radioactive iodine nuclides which are produced in nuclear plants consist mainly of short lived 131 I- 135 I, while 129 I with long half life is being produced in a small amount. The radioactivity of iodine in a power reactor of 1,000 MWe which burns uranium fuel amounts to about 6 x 10 8 C sub(i). In the case of fuel which is handled in a reprocessing plant of spent fuel, almost all radioactive iodine remaining in the fuel is 129 I (half life: 1.7 x 10 7 years) because of cooling period of more than 6 months which is imposed by the plant. 2. Release of radioactive iodine during normal operating conditions. In an event of fuel failure in light water cooled reactors, a part of radioactive iodine is dissolved in water and very small amount is released as gaseous iodine to the environment through the ventillation system. The actual amount of radioactive iodine which was released from various types of nuclear reactors in the world between 1970 to 1974 is recorded as much lower than to the presently regulated value in all cases. 3. Behavior of radioactive iodine during postulated accident. The amount of radioactive iodine which will be released from reactor core to the containment vessel varies with conditions to be assumed. In the event of a severe accidental condition such as fuel melt down or oxidation, 25% of radioactive iodine in the fuel are assumed to be released. The iodine released to the containment vessel is mostly removed by planting out to the wall of the containment or washed out by core spray, while the remaining part in air is to be removed by a filter unit which is installed in the emergency gas treatment system. (author)

  15. Extinction Events Can Accelerate Evolution

    DEFF Research Database (Denmark)

    Lehman, Joel; Miikkulainen, Risto

    2015-01-01

    Extinction events impact the trajectory of biological evolution significantly. They are often viewed as upheavals to the evolutionary process. In contrast, this paper supports the hypothesis that although they are unpredictably destructive, extinction events may in the long term accelerate...... evolution by increasing evolvability. In particular, if extinction events extinguish indiscriminately many ways of life, indirectly they may select for the ability to expand rapidly through vacated niches. Lineages with such an ability are more likely to persist through multiple extinctions. Lending...... computational support for this hypothesis, this paper shows how increased evolvability will result from simulated extinction events in two computational models of evolved behavior. The conclusion is that although they are destructive in the short term, extinction events may make evolution more prolific...

  16. SHAKER Version 0.0/5 Pre-release Notes

    CERN Document Server

    CERN. Geneva

    1993-01-01

    SHAKER V0.0/5 is a pre-release of a simple cocktail central rapidity phase space event generator developed for the simulation of LHC Heavy Ion events. A modified version of JETSET 7.3 (the / LUJETS / common has been enlarged to 50000 particles and the LUEDIT routine has been modified to rearrange the particle weights vectors when called with MEDIT=1) is used to manage the events. All event information is included in / LUJETS / according to Lund conventions [1].

  17. Understanding Drug Release Data through Thermodynamic Analysis

    Directory of Open Access Journals (Sweden)

    Marjorie Caroline Liberato Cavalcanti Freire

    2017-06-01

    Full Text Available Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas–Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.

  18. Understanding Drug Release Data through Thermodynamic Analysis

    Science.gov (United States)

    Freire, Marjorie Caroline Liberato Cavalcanti; Alexandrino, Francisco; Marcelino, Henrique Rodrigues; Picciani, Paulo Henrique de Souza; Silva, Kattya Gyselle de Holanda e; Genre, Julieta; de Oliveira, Anselmo Gomes; do Egito, Eryvaldo Sócrates Tabosa

    2017-01-01

    Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas–Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability. PMID:28773009

  19. Understanding Drug Release Data through Thermodynamic Analysis.

    Science.gov (United States)

    Freire, Marjorie Caroline Liberato Cavalcanti; Alexandrino, Francisco; Marcelino, Henrique Rodrigues; Picciani, Paulo Henrique de Souza; Silva, Kattya Gyselle de Holanda E; Genre, Julieta; Oliveira, Anselmo Gomes de; Egito, Eryvaldo Sócrates Tabosa do

    2017-06-13

    Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.

  20. Events as Power Source: Wireless Sustainable Corrosion Monitoring

    OpenAIRE

    Sun, Guodong; Qiao, Guofu; Zhao, Lin; Chen, Zhibo

    2013-01-01

    This study presents and implements a corrosion-monitoring wireless sensor platform, EPS (Events as Power Source), which monitors the corrosion events in reinforced concrete (RC) structures, while being powered by the micro-energy released from the corrosion process. In EPS, the proposed corrosion-sensing device serves both as the signal source for identifying corrosion and as the power source for driving the sensor mote, because the corrosion process (event) releases electric energy; this is ...

  1. Large scientific releases

    International Nuclear Information System (INIS)

    Pongratz, M.B.

    1981-01-01

    The motivation for active experiments in space is considered, taking into account the use of active techniques to obtain a better understanding of the natural space environment, the utilization of the advantages of space as a laboratory to study fundamental plasma physics, and the employment of active techniques to determine the magnitude, degree, and consequences of artificial modification of the space environment. It is pointed out that mass-injection experiments in space plasmas began about twenty years ago with the Project Firefly releases. Attention is given to mass-release techniques and diagnostics, operational aspects of mass release active experiments, the active observation of mass release experiments, active perturbation mass release experiments, simulating an artificial modification of the space environment, and active experiments to study fundamental plasma physics

  2. Determining probabilities of geologic events and processes

    International Nuclear Information System (INIS)

    Hunter, R.L.; Mann, C.J.; Cranwell, R.M.

    1985-01-01

    The Environmental Protection Agency has recently published a probabilistic standard for releases of high-level radioactive waste from a mined geologic repository. The standard sets limits for contaminant releases with more than one chance in 100 of occurring within 10,000 years, and less strict limits for releases of lower probability. The standard offers no methods for determining probabilities of geologic events and processes, and no consensus exists in the waste-management community on how to do this. Sandia National Laboratories is developing a general method for determining probabilities of a given set of geologic events and processes. In addition, we will develop a repeatable method for dealing with events and processes whose probability cannot be determined. 22 refs., 4 figs

  3. Vaccine Adverse Events

    Science.gov (United States)

    ... for Biologics Evaluation & Research Vaccine Adverse Events Vaccine Adverse Events Share Tweet Linkedin Pin it More sharing ... in the primary immunization series in infants Report Adverse Event Report a Vaccine Adverse Event Contact FDA ( ...

  4. The effect of release liner materials on adhesive contaminants, paper recycling and recycled paper properties

    Science.gov (United States)

    Richard Venditti; Richard Gilbert; Andy Zhang; Said Abubakr

    2000-01-01

    Release liner waste material is found in post-consumer waste streams and is also a significant component of the preconsumer waste stream generated in the manufacturing of adhesive products. To date, very little has been reported pertaining to the behavior of release liner in paper recycling. In this study, the effect of the release liner material on the behavior of...

  5. [Preparation of hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata and study on its in vitro release mechanism].

    Science.gov (United States)

    Xu, Fang-Fang; Shi, Wei; Zhang, Hui; Guo, Qing-Ming; Wang Zhen-Zhong; Bi, Yu-An; Wang, Zhi-Min; Xiao, Wei

    2015-01-01

    In this study, hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata were prepared and the in vitro release behavior were also evaluated. The optimal prescription was achieved by studying the main factor of the type and amount of hydroxypropyl methylcellulose (HPMC) using single factor test and evaluating through cumulative release of three lactones. No burst drug release from the obtained matrix tablets was observed. Drug release sustained to 14 h. The release mechanism of three lactones from A. paniculata was accessed by zero-order, first-order, Higuchi and Peppas equation. The release behavior of total lactones from A. paniculata was better agreed with Higuchi model and the drug release from the tablets was controlled by degradation of the matrix. The preparation of hydrophilic matrix sustained release tablets of total lactones from A. paniculata with good performance of drug release was simple.

  6. 32 CFR 644.466 - Release and record of physical restoration.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Disposal of Leaseholds and Leasehold Improvements... collateral proceedings, in the event a release is not obtained. Where litigation is anticipated, photographic...

  7. Analysis of an LPG accidental release

    Energy Technology Data Exchange (ETDEWEB)

    Demichela, M.; Piccinini, N.; Poggio, A.

    2004-03-01

    An industrial LPG storage accident due to the release of propane from a tanker is described in this paper and the sequence of events that led to the collapse of a storage tank is examined using simulation software. A model taking both released flows into account as a radiant thermal contribution in the presence of flames is presented. The progression of the accident is assessed through digitalization and processing of the film of the fireball produced by about 500 L of LPG, whose diameter was calculated as approximately 50 m. (author)

  8. Visual pattern discovery in timed event data

    Science.gov (United States)

    Schaefer, Matthias; Wanner, Franz; Mansmann, Florian; Scheible, Christian; Stennett, Verity; Hasselrot, Anders T.; Keim, Daniel A.

    2011-01-01

    Business processes have tremendously changed the way large companies conduct their business: The integration of information systems into the workflows of their employees ensures a high service level and thus high customer satisfaction. One core aspect of business process engineering are events that steer the workflows and trigger internal processes. Strict requirements on interval-scaled temporal patterns, which are common in time series, are thereby released through the ordinal character of such events. It is this additional degree of freedom that opens unexplored possibilities for visualizing event data. In this paper, we present a flexible and novel system to find significant events, event clusters and event patterns. Each event is represented as a small rectangle, which is colored according to categorical, ordinal or intervalscaled metadata. Depending on the analysis task, different layout functions are used to highlight either the ordinal character of the data or temporal correlations. The system has built-in features for ordering customers or event groups according to the similarity of their event sequences, temporal gap alignment and stacking of co-occurring events. Two characteristically different case studies dealing with business process events and news articles demonstrate the capabilities of our system to explore event data.

  9. The 2017 Release Cloudy

    Science.gov (United States)

    Ferland, G. J.; Chatzikos, M.; Guzmán, F.; Lykins, M. L.; van Hoof, P. A. M.; Williams, R. J. R.; Abel, N. P.; Badnell, N. R.; Keenan, F. P.; Porter, R. L.; Stancil, P. C.

    2017-10-01

    We describe the 2017 release of the spectral synthesis code Cloudy, summarizing the many improvements to the scope and accuracy of the physics which have been made since the previous release. Exporting the atomic data into external data files has enabled many new large datasets to be incorporated into the code. The use of the complete datasets is not realistic for most calculations, so we describe the limited subset of data used by default, which predicts significantly more lines than the previous release of Cloudy. This version is nevertheless faster than the previous release, as a result of code optimizations. We give examples of the accuracy limits using small models, and the performance requirements of large complete models. We summarize several advances in the H- and He-like iso-electronic sequences and use our complete collisional-radiative models to establish the densities where the coronal and local thermodynamic equilibrium approximations work.

  10. EIA new releases

    International Nuclear Information System (INIS)

    1994-09-01

    This report is a compliation of news releases from the Energy Information Administration. The september-october report includes articles on energy conservation, energy consumption in commercial buildings, and a short term energy model for a personal computer

  11. Sellafield (release of radioactivity)

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, J; Goodlad, A; Morris, M

    1986-02-06

    A government statement is reported, about the release of plutonium nitrate at the Sellafield site of British Nuclear Fuels plc on 5 February 1986. Matters raised included: details of accident; personnel monitoring; whether radioactive material was released from the site; need for public acceptance of BNFL activities; whether plant should be closed; need to reduce level of radioactive effluent; number of incidents at the plant.

  12. Topology of Event Horizon

    OpenAIRE

    Siino, Masaru

    1997-01-01

    The topologies of event horizons are investigated. Considering the existence of the endpoint of the event horizon, it cannot be differentiable. Then there are the new possibilities of the topology of the event horizon though they are excluded in smooth event horizons. The relation between the topology of the event horizon and the endpoint of it is revealed. A torus event horizon is caused by two-dimensional endpoints. One-dimensional endpoints provide the coalescence of spherical event horizo...

  13. Fire Behavior (FB)

    Science.gov (United States)

    Robert E. Keane

    2006-01-01

    The Fire Behavior (FB) method is used to describe the behavior of the fire and the ambient weather and fuel conditions that influence the fire behavior. Fire behavior methods are not plot based and are collected by fire event and time-date. In general, the fire behavior data are used to interpret the fire effects documented in the plot-level sampling. Unlike the other...

  14. An understanding of modified release matrix tablets behavior during drug dissolution as the key for prediction of pharmaceutical product performance - case study of multimodal characterization of quetiapine fumarate tablets.

    Science.gov (United States)

    Kulinowski, Piotr; Woyna-Orlewicz, Krzysztof; Rappen, Gerd-Martin; Haznar-Garbacz, Dorota; Węglarz, Władysław P; Dorożyński, Przemysław P

    2015-04-30

    Motivation for the study was the lack of dedicated and effective research and development (R&D) in vitro methods for oral, generic, modified release formulations. The purpose of the research was to assess multimodal in vitro methodology for further bioequivalence study risk minimization. Principal results of the study are as follows: (i) Pharmaceutically equivalent quetiapine fumarate extended release dosage form of Seroquel XR was developed using a quality by design/design of experiment (QbD/DoE) paradigm. (ii) The developed formulation was then compared with originator using X-ray microtomography, magnetic resonance imaging and texture analysis. Despite similarity in terms of compendial dissolution test, developed and original dosage forms differed in micro/meso structure and consequently in mechanical properties. (iii) These differences were found to be the key factors of failure of biorelevant dissolution test using the stress dissolution apparatus. Major conclusions are as follows: (i) Imaging methods allow to assess internal features of the hydrating extended release matrix and together with the stress dissolution test allow to rationalize the design of generic formulations at the in vitro level. (ii) Technological impact on formulation properties e.g., on pore formation in hydrating matrices cannot be overlooked when designing modified release dosage forms. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Feeding Releases Endogenous Opioids in Humans.

    Science.gov (United States)

    Tuulari, Jetro J; Tuominen, Lauri; de Boer, Femke E; Hirvonen, Jussi; Helin, Semi; Nuutila, Pirjo; Nummenmaa, Lauri

    2017-08-23

    The endogenous opioid system supports a multitude of functions related to appetitive behavior in humans and animals, and it has been proposed to govern hedonic aspects of feeding thus contributing to the development of obesity. Here we used positron emission tomography to investigate whether feeding results in hedonia-dependent endogenous opioid release in humans. Ten healthy males were recruited for the study. They were scanned with the μ-opioid-specific ligand [ 11 C]carfentanil three times, as follows: after a palatable meal, a nonpalatable meal, and after an overnight fast. Subjective mood, satiety, and circulating hormone levels were measured. Feeding induced significant endogenous opioid release throughout the brain. This response was more pronounced following a nonpalatable meal versus a palatable meal, and independent of the subjective hedonic responses to feeding. We conclude that feeding consistently triggers cerebral opioid release even in the absence of subjective pleasure associated with feeding, suggesting that metabolic and homeostatic rather than exclusively hedonic responses play a role in the feeding-triggered cerebral opioid release. SIGNIFICANCE STATEMENT The endogenous opioid system supports both hedonic and homeostatic functions. It has been proposed that overeating and concomitant opioid release could downregulate opioid receptors and promote the development of obesity. However, it remains unresolved whether feeding leads to endogenous opioid release in humans. We used in vivo positron emission tomography to test whether feeding triggers cerebral opioid release and whether this response is associated with pleasurable sensations. We scanned volunteers using the μ-opioid receptor-specific radioligand [ 11 C]carfentanil three times, as follows: after an overnight fast, after consuming a palatable meal, and after consuming a nonpalatable meal. Feeding led to significant endogenous opioid release, and this occurred also in the absence of feeding

  16. Drug Release Studies from Caesalpinia pulcherrima Seed Polysaccharide

    OpenAIRE

    Jeevanandham, Somasundaram; Dhachinamoorthi, Duraiswamy; Bannoth Chandra Sekhar, Kothapalli

    2011-01-01

    This study examines the controlled release behavior of both water-soluble (acetaminophen, caffeine, theophylline and salicylic acid) and water insoluble (indomethacin) drugs derived from Caesalpinia pulcherrima seed Gum isolated from Caesalpinia pulcherrima kernel powder. It further investigates the effect of incorporating diluents such as microcrystalline cellulose and lactose on caffeine release. In addition the effect the gum?s (polysaccharide) partial cross-linking had on release of aceta...

  17. PRELIMINARY SELECTION OF MGR DESIGN BASIS EVENTS

    International Nuclear Information System (INIS)

    Kappes, J.A.

    1999-01-01

    The purpose of this analysis is to identify the preliminary design basis events (DBEs) for consideration in the design of the Monitored Geologic Repository (MGR). For external events and natural phenomena (e.g., earthquake), the objective is to identify those initiating events that the MGR will be designed to withstand. Design criteria will ensure that radiological release scenarios resulting from these initiating events are beyond design basis (i.e., have a scenario frequency less than once per million years). For internal (i.e., human-induced and random equipment failures) events, the objective is to identify credible event sequences that result in bounding radiological releases. These sequences will be used to establish the design basis criteria for MGR structures, systems, and components (SSCs) design basis criteria in order to prevent or mitigate radiological releases. The safety strategy presented in this analysis for preventing or mitigating DBEs is based on the preclosure safety strategy outlined in ''Strategy to Mitigate Preclosure Offsite Exposure'' (CRWMS M andO 1998f). DBE analysis is necessary to provide feedback and requirements to the design process, and also to demonstrate compliance with proposed 10 CFR 63 (Dyer 1999b) requirements. DBE analysis is also required to identify and classify the SSCs that are important to safety (ITS)

  18. Formulation of Sustained-Release Diltiazem Matrix Tablets Using ...

    African Journals Online (AJOL)

    Erah

    surface, their drug release behavior appears simple, but ... matrix material for the formulation of ..... formulation F5 (,) and reference formulations. ( , □). 0. 50. 100. 150. 200. 250. 300. 0. 3. 6 .... Coviello T, Matricardi P, Marianecci C, Alhaique F.

  19. Herwig++ 2.6 release note

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, K.; Gieseke, S.; Roehr, C. [Karlsruher Institut fuer Technologie, Karlsruhe (DE). Inst. fuer Theoretische Physik] (and others)

    2012-05-15

    A new release of the Monte Carlo event generator Herwig++ (version 2.6) is now available. This version comes with a number of improvements including: a new structure for the implementation of next-to-leading order matrix elements; an improved treatment of wide-angle gluon radiation; new hard-coded next-to-leading order matrix elements for deep inelastic scattering and weak vector boson fusion; additional models of physics beyond the StandardModel, including the production of colour sextet particles; a statistical colour reconnection model; automated energy scaling of underlying-event tunes.

  20. Herwig++ 2.6 release note

    International Nuclear Information System (INIS)

    Arnold, K.; Gieseke, S.; Roehr, C.

    2012-05-01

    A new release of the Monte Carlo event generator Herwig++ (version 2.6) is now available. This version comes with a number of improvements including: a new structure for the implementation of next-to-leading order matrix elements; an improved treatment of wide-angle gluon radiation; new hard-coded next-to-leading order matrix elements for deep inelastic scattering and weak vector boson fusion; additional models of physics beyond the StandardModel, including the production of colour sextet particles; a statistical colour reconnection model; automated energy scaling of underlying-event tunes.

  1. An analysis of the additional fission product release phenomena

    International Nuclear Information System (INIS)

    Takeda, Tsuneo; Nagai, Hitoshi

    1978-09-01

    The additional fission product release behavior through a defect hole on the cladding of fuel rods has been studied qualitatively with a computer program CODAC-ARFP. The additional fission product release phenomena are described as qualitative evaluation. The additional fission product release behavior in coolant temperature and pressure fluctuations and in reactor start-up and shut-down depends on coolant water flow behavior into and from the free space of fuel rods through a defect hole. Based on the results of evaluations, the experimental results with an inpile water loop OWL-1 are described in detail. The estimation methods of fission product quantity in the free space and fission product release ratio (quantity released into the coolant/quantity in the free space before beginning of release) are necessary for analysis of the fission product release behavior; the estimation method of water flow through a defect hole is also necessary. In development of the above estimation methods, outpile and capsule experiments supporting the additional fission product release experiments are required. (author)

  2. Event segmentation ability uniquely predicts event memory.

    Science.gov (United States)

    Sargent, Jesse Q; Zacks, Jeffrey M; Hambrick, David Z; Zacks, Rose T; Kurby, Christopher A; Bailey, Heather R; Eisenberg, Michelle L; Beck, Taylor M

    2013-11-01

    Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for by general cognitive abilities? Two hundred and eight adults ranging from 20 to 79years old segmented movies of everyday events and attempted to remember the events afterwards. They also completed psychometric ability tests and tests measuring script knowledge for everyday events. Event segmentation and script knowledge both explained unique variance in event memory above and beyond the psychometric measures, and did so as strongly in older as in younger adults. These results suggest that event segmentation is a basic cognitive mechanism, important for memory across the lifespan. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Biological processes influencing contaminant release from sediments

    International Nuclear Information System (INIS)

    Reible, D.D.

    1996-01-01

    The influence of biological processes, including bioturbation, on the mobility of contaminants in freshwater sediments is described. Effective mass coefficients are estimated for tubificid oligochaetes as a function of worm behavior and biomass density. The mass transfer coefficients were observed to be inversely proportional to water oxygen content and proportional to the square root of biomass density. The sediment reworking and contaminant release are contrasted with those of freshwater amphipods. The implications of these and other biological processes for contaminant release and i n-situ remediation of soils and sediments are summarized. 4 figs., 1 tab

  4. GENIE Production Release 2.10.0

    Energy Technology Data Exchange (ETDEWEB)

    Alam, M. [Aligarh Muslim Univ., Aligarh (India). Dept. of Physics; Andreopoulos, C. [Univ. of Liverpool (United Kingdom). Dept. of Physics; Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL); Athar, M. [Aligarh Muslim Univ., Aligarh (India). Dept. of Physics; Bodek, A. [Univ. of Rochester, NY (United States). Dept. of Physics; Christy, E. [Hampton Univ., Hampton, VA (United States). Dept. of Physics; Coopersmith, B. [Univ. of Rochester, NY (United States). Dept. of Physics; Dennis, S. [Univ. of Warwick, Coventry (United Kingdom). Dept .of Physics; Dytman, S. [Univ. of Pittsburgh, PA (United States). Dept. of Physics and Astronomy; Gallagher, H. [Tufts Univ., Medford, MA (United States). Dept. of Physics and Astronomy; Geary, N. [Univ. of Pittsburgh, PA (United States). Dept. of Physics and Astronomy; Golan, T. [Univ. of Rochester, NY (United States). Dept. of Physics; Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Hatcher, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Hoshina, K. [Univ. of Wisconsin, Madison, WI (United States). Dept. of Physics. Wisconsin IceCube Particle Astrophysics Center; Liu, J. [College of William and Mary, Williamsburg, VA (United States). Dept. of Physics; Mahn, K. [Michigan State Univ., East Lansing, MI (United States). Dept. of Physics and Astronomy; Marshall, C. [Univ. of Rochester, NY (United States). Dept. of Physics; Morrison, J. [Michigan State Univ., East Lansing, MI (United States). Dept. of Physics and Astronomy; Nirkko, M. [Univ. of Bern (Switzerland). Albert Einstein Center for Fundamental Physics. Lab. for High Energy Physics (LHEP); Nowak, J. [Lancaster Univ. (United Kingdom). Dept. of Physics; Perdue, G. N. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Yarba, J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2015-12-25

    GENIE is a neutrino Monte Carlo event generator that simulates the primary interaction of a neutrino with a nuclear target, along with the subsequent propagation of the reaction products through the nuclear medium. It additionally contains libraries for fully-featured detector geometries and for managing various types of neutrino flux. This note details recent updates to GENIE, in particular, changes introduced into the newest production release, version 2.10.0.

  5. GENIE Production Release 2.10.0

    International Nuclear Information System (INIS)

    Alam, M.; Athar, M.; Hatcher, R.; Hoshina, K.; Nowak, J.; Yarba, J.

    2015-01-01

    GENIE is a neutrino Monte Carlo event generator that simulates the primary interaction of a neutrino with a nuclear target, along with the subsequent propagation of the reaction products through the nuclear medium. It additionally contains libraries for fully-featured detector geometries and for managing various types of neutrino flux. This note details recent updates to GENIE, in particular, changes introduced into the newest production release, version 2.10.0.

  6. ATP Release Channels

    Directory of Open Access Journals (Sweden)

    Akiyuki Taruno

    2018-03-01

    Full Text Available Adenosine triphosphate (ATP has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. In addition to the classical exocytosis, non-vesicular mechanisms of cellular ATP release have been demonstrated in many cell types. Although large and negatively charged ATP molecules cannot diffuse across the lipid bilayer of the plasma membrane, conductive ATP release from the cytosol into the extracellular space is possible through ATP-permeable channels. Such channels must possess two minimum qualifications for ATP permeation: anion permeability and a large ion-conducting pore. Currently, five groups of channels are acknowledged as ATP-release channels: connexin hemichannels, pannexin 1, calcium homeostasis modulator 1 (CALHM1, volume-regulated anion channels (VRACs, also known as volume-sensitive outwardly rectifying (VSOR anion channels, and maxi-anion channels (MACs. Recently, major breakthroughs have been made in the field by molecular identification of CALHM1 as the action potential-dependent ATP-release channel in taste bud cells, LRRC8s as components of VRACs, and SLCO2A1 as a core subunit of MACs. Here, the function and physiological roles of these five groups of ATP-release channels are summarized, along with a discussion on the future implications of understanding these channels.

  7. Containment closure time following the loss of shutdown cooling event of YGN Units 3 and 4

    International Nuclear Information System (INIS)

    Seul, Kwang Won; Bang, Young Seok; Kim, Hho Jung

    1999-01-01

    The YGN Units 3 and 4 plant conditions during shutdown operation were reviewed to identify the possible event scenarios following the loss of shutdown cooling (SDC) event. For the five cases of typical reactor coolant system (RCS) configurations under the worst event sequence, such as unavailable secondary cooling and no RCS inventory makeup, the thermal hydraulic analyses were performed using the RELAP5/MOS3.2 code to investigate the plant behavior following the event. The thermal hydraulic analyses include the estimation of time to boil, time to core uncovery, and time to core heat up to determine the containment closure time to prevent the uncontrolled release of fission products to atmosphere. The result indicates that the containment closure is recommended to be achieved within 42 minutes after the loss of SDC for the steam generator (SG) inlet plenum manway open case or the large cold leg open case under the worst event sequence. The containment closure time is significantly dependent on the elevation and size of the opening and the SG secondary water level condition. It is also found that the containment closure needs to be initiated before the boiling time to ensure the survivability of the workers in the containment. These results will provide using information to operators to cope with the loss of SDC event. (Author). 15 refs., 3 tabs., 7 figs

  8. Life events and Tourette syndrome.

    Science.gov (United States)

    Steinberg, Tamar; Shmuel-Baruch, Sharona; Horesh, Netta; Apter, Alan

    2013-07-01

    events, significant correlation was found between the quantity of major life events and the severity of motor tics, but not vocal tics. Regarding comorbidities and major life events, significant correlation was found between the severity of compulsions, ADHD, and aggression and the subjects' personal evaluation of the effect of negative major life events on their lives. Minor life events appear to be correlated with tic severity and comorbidities in children and adolescents with Tourette syndrome. The lack of an association between major life events and tic severity further emphasizes the salient impact of minor life events that occur in temporal proximity to the assessment of tic severity. Clinically, the results match our impression from patient narratives wherein they "blamed" the exacerbations in tics on social interactions. The high correlation between negative life events and depression, anxiety and compulsions symptoms, were reported also in previous studies. In conclusion, These findings may have clinical implications for planning supportive psychotherapy or cognitive behavioral therapy for this patient population. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Design and evaluation of nicorandil extended-release tablet

    Directory of Open Access Journals (Sweden)

    Ju-Young Kim

    2015-04-01

    Full Text Available The aim of this study was to design and evaluate extended-release formulations of a model drug, nicorandil, in order to achieve the desired steady-state plasma concentration of drug in vivo. Simulation was employed to estimate optimum dissolution and absorption rate of nicorandil. The dissolution test was employed using pH 1.2, 4.0, 6.8 buffer solution, or water, to measure the in vitro release behaviors of nicorandil formulations. A single dose (15 mg of each formulation was orally administered to four beagle dogs under fasted conditions, and the pharmacokinetic parameters were calculated. The in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle dogs. Nicorandil was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release tablets. The nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release formulation. The release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extended-release formulations. These results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

  10. Public Health Events and International Health Regulations

    Centers for Disease Control (CDC) Podcasts

    2012-06-21

    Dr. Katrin Kohl, a medical officer at the CDC, discusses the World Health Organization’s International Health Regulations for assessing and reporting on public health events across the world.  Created: 6/21/2012 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 6/21/2012.

  11. RAVEN Beta Release

    International Nuclear Information System (INIS)

    Rabiti, Cristian; Alfonsi, Andrea; Cogliati, Joshua Joseph; Mandelli, Diego; Kinoshita, Robert Arthur; Wang, Congjian; Maljovec, Daniel Patrick; Talbot, Paul William

    2016-01-01

    This documents the release of the Risk Analysis Virtual Environment (RAVEN) code. A description of the RAVEN code is provided, and discussion of the release process for the M2LW-16IN0704045 milestone. The RAVEN code is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. RAVEN is capable of investigating the system response as well as the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. RAVEN has now increased in maturity enough for the Beta 1.0 release.

  12. RAVEN Beta Release

    Energy Technology Data Exchange (ETDEWEB)

    Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alfonsi, Andrea [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cogliati, Joshua Joseph [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mandelli, Diego [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinoshita, Robert Arthur [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wang, Congjian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Maljovec, Daniel Patrick [Idaho National Lab. (INL), Idaho Falls, ID (United States); Talbot, Paul William [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-02-01

    This documents the release of the Risk Analysis Virtual Environment (RAVEN) code. A description of the RAVEN code is provided, and discussion of the release process for the M2LW-16IN0704045 milestone. The RAVEN code is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. RAVEN is capable of investigating the system response as well as the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. RAVEN has now increased in maturity enough for the Beta 1.0 release.

  13. A review for identification of initiating events in event tree development process on nuclear power plants

    International Nuclear Information System (INIS)

    Riyadi, Eko H.

    2014-01-01

    Initiating event is defined as any event either internal or external to the nuclear power plants (NPPs) that perturbs the steady state operation of the plant, if operating, thereby initiating an abnormal event such as transient or loss of coolant accident (LOCA) within the NPPs. These initiating events trigger sequences of events that challenge plant control and safety systems whose failure could potentially lead to core damage or large early release. Selection for initiating events consists of two steps i.e. first step, definition of possible events, such as by evaluating a comprehensive engineering, and by constructing a top level logic model. Then the second step, grouping of identified initiating event's by the safety function to be performed or combinations of systems responses. Therefore, the purpose of this paper is to discuss initiating events identification in event tree development process and to reviews other probabilistic safety assessments (PSA). The identification of initiating events also involves the past operating experience, review of other PSA, failure mode and effect analysis (FMEA), feedback from system modeling, and master logic diagram (special type of fault tree). By using the method of study for the condition of the traditional US PSA categorization in detail, could be obtained the important initiating events that are categorized into LOCA, transients and external events

  14. A review for identification of initiating events in event tree development process on nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Riyadi, Eko H., E-mail: e.riyadi@bapeten.go.id [Center for Regulatory Assessment of Nuclear Installation and Materials, Nuclear Energy Regulatory Agency (BAPETEN), Jl. Gajah Mada 8 Jakarta 10120 (Indonesia)

    2014-09-30

    Initiating event is defined as any event either internal or external to the nuclear power plants (NPPs) that perturbs the steady state operation of the plant, if operating, thereby initiating an abnormal event such as transient or loss of coolant accident (LOCA) within the NPPs. These initiating events trigger sequences of events that challenge plant control and safety systems whose failure could potentially lead to core damage or large early release. Selection for initiating events consists of two steps i.e. first step, definition of possible events, such as by evaluating a comprehensive engineering, and by constructing a top level logic model. Then the second step, grouping of identified initiating event's by the safety function to be performed or combinations of systems responses. Therefore, the purpose of this paper is to discuss initiating events identification in event tree development process and to reviews other probabilistic safety assessments (PSA). The identification of initiating events also involves the past operating experience, review of other PSA, failure mode and effect analysis (FMEA), feedback from system modeling, and master logic diagram (special type of fault tree). By using the method of study for the condition of the traditional US PSA categorization in detail, could be obtained the important initiating events that are categorized into LOCA, transients and external events.

  15. Behavior of explosion debris clouds

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    In the normal course of events the behavior of debris clouds created by explosions will be of little concern to the atomic energy industry. However, two situations, one of them actual and one postulated, exist where the rise and spread of explosion clouds can affect site operations. The actual occurrence would be the detonation of nuclear weapons and the resultant release and transport of radioactive debris across the various atomic energy installations. Although the activity of the diffusing cloud is not of biological concern, it may still be sufficiently above background to play havoc with the normal readings of sensitive monitoring instruments. If it were not known that these anomalous readings resulted from explosion debris, considerable time and expense might be required for on-site testing and tracing. Fortunately it is usually possible, with the use of meteorological data and forecasts, to predict when individual sites are affected by nuclear weapon debris effects. The formation rise, and diffusion of weapon clouds will be discussed. The explosion of an atomic reactor is the postulated situation. It is common practice in reactor hazard analysis to assume a combination of circumstances which might result in a nuclear incident with a release of material to the atmosphere. It is not within the scope of this report to examine the manifold plausibilities that might lead to an explosion or the possible methods of release of gaseous and/or particulates from such an occurrence. However, if the information of a cloud is assumed and some idea of its energy content is obtainable, estimates of the cloud behavior in the atmosphere can be made

  16. Symbiotic Optimization of Behavior

    Science.gov (United States)

    2015-05-01

    SYMBIOTIC OPTIMIZATION OF BEHAVIOR UNIVERSITY OF WASHINGTON MAY 2015 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED...2014 4. TITLE AND SUBTITLE SYMBIOTIC OPTIMIZATION OF BEHAVIOR 5a. CONTRACT NUMBER FA8750-12-1-0304 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT

  17. Event dependent sampling of recurrent events

    DEFF Research Database (Denmark)

    Kvist, Tine Kajsa; Andersen, Per Kragh; Angst, Jules

    2010-01-01

    The effect of event-dependent sampling of processes consisting of recurrent events is investigated when analyzing whether the risk of recurrence increases with event count. We study the situation where processes are selected for study if an event occurs in a certain selection interval. Motivation...... retrospective and prospective disease course histories are used. We examine two methods to correct for the selection depending on which data are used in the analysis. In the first case, the conditional distribution of the process given the pre-selection history is determined. In the second case, an inverse...

  18. Minimizing employee exposure to toxic chemical releases

    International Nuclear Information System (INIS)

    Plummer, R.W.; Stobbe, T.J.; Mogensen, J.E.; Jeram, L.K.

    1987-01-01

    This book describes procedures for minimizing employee exposure to toxic chemical releases and suggested personal protective equipment (PPE) to be used in the event of such chemical release. How individuals, employees, supervisors, or companies perceive the risks of chemical exposure (risk meaning both probability of exposure and effect of exposure) determines to a great extent what precautions are taken to avoid risk. In Part I, the authors develop and approach which divides the project into three phases: kinds of procedures currently being used; the types of toxic chemical release accidents and injuries that occur; and, finally, integration of this information into a set of recommended procedures which should decrease the likelihood of a toxic chemical release and, if one does occur, will minimize the exposure and its severity to employees. Part II covers the use of personal protective equipment. It addresses the questions: what personal protective equipment ensembles are used in industry in situations where the release of a toxic or dangerous chemical may occur or has occurred; and what personal protective equipment ensembles should be used in these situations

  19. Safety barriers to prevent release of hydrocarbons during production of oil and gas

    OpenAIRE

    Sklet, Snorre; Hauge, Stein

    2004-01-01

    This report documents a set of scenarios related to release of hydrocarbons during production on oil and gas platforms. For each release scenario, initiating events, barrier functions aimed to prevent loss of containment, and barrier systems that realize these barrier functions are identified and described. Safety barriers to prevent release of hydrocarbons during production of oil and gas

  20. Hydraulic release oil tool

    International Nuclear Information System (INIS)

    Mims, M.G.; Mueller, M.D.; Ehlinger, J.C.

    1992-01-01

    This patent describes a hydraulic release tool. It comprises a setting assembly; a coupling member for coupling to drill string or petroleum production components, the coupling member being a plurality of sockets for receiving the dogs in the extended position and attaching the coupling member the setting assembly; whereby the setting assembly couples to the coupling member by engagement of the dogs in the sockets of releases from and disengages the coupling member in movement of the piston from its setting to its reposition in response to a pressure in the body in exceeding the predetermined pressure; and a relief port from outside the body into its bore and means to prevent communication between the relief port and the bore of the body axially of the piston when the piston is in the setting position and to establish such communication upon movement of the piston from the setting position to the release position and reduce the pressure in the body bore axially of the piston, whereby the reduction of the pressure signals that the tool has released the coupling member

  1. APASS Data Release 10

    Science.gov (United States)

    Henden, Arne A.; Levine, Stephen; Terrell, Dirk; Welch, Douglas L.; Munari, Ulisse; Kloppenborg, Brian K.

    2018-06-01

    The AAVSO Photometric All-Sky Survey (APASS) has been underway since 2010. This survey covers the entire sky from 7.5 knowledge of the optical train distortions. With these changes, DR10 includes many more stars than prior releases. We describe the survey, its remaining limitations, and prospects for the future, including a very-bright-star extension.

  2. Release the Prisoners Game

    Science.gov (United States)

    Van Hecke, Tanja

    2011-01-01

    This article presents the mathematical approach of the optimal strategy to win the "Release the prisoners" game and the integration of this analysis in a math class. Outline lesson plans at three different levels are given, where simulations are suggested as well as theoretical findings about the probability distribution function and its mean…

  3. Level 2 probabilistic event analyses and quantification

    International Nuclear Information System (INIS)

    Boneham, P.

    2003-01-01

    In this paper an example of quantification of a severe accident phenomenological event is given. The performed analysis for assessment of the probability that the debris released from the reactor vessel was in a coolable configuration in the lower drywell is presented. It is also analysed the assessment of the type of core/concrete attack that would occur. The coolability of the debris ex-vessel evaluation by an event in the Simplified Boiling Water Reactor (SBWR) Containment Event Tree (CET) and a detailed Decomposition Event Tree (DET) developed to aid in the quantification of this CET event are considered. The headings in the DET selected to represent plant physical states (e.g., reactor vessel pressure at the time of vessel failure) and the uncertainties associated with the occurrence of critical physical phenomena (e.g., debris configuration in the lower drywell) considered important to assessing whether the debris was coolable or not coolable ex-vessel are also discussed

  4. Event generators for address event representation transmitters

    Science.gov (United States)

    Serrano-Gotarredona, Rafael; Serrano-Gotarredona, Teresa; Linares Barranco, Bernabe

    2005-06-01

    Address Event Representation (AER) is an emergent neuromorphic interchip communication protocol that allows for real-time virtual massive connectivity between huge number neurons located on different chips. By exploiting high speed digital communication circuits (with nano-seconds timings), synaptic neural connections can be time multiplexed, while neural activity signals (with mili-seconds timings) are sampled at low frequencies. Also, neurons generate 'events' according to their activity levels. More active neurons generate more events per unit time, and access the interchip communication channel more frequently, while neurons with low activity consume less communication bandwidth. In a typical AER transmitter chip, there is an array of neurons that generate events. They send events to a peripheral circuitry (let's call it "AER Generator") that transforms those events to neurons coordinates (addresses) which are put sequentially on an interchip high speed digital bus. This bus includes a parallel multi-bit address word plus a Rqst (request) and Ack (acknowledge) handshaking signals for asynchronous data exchange. There have been two main approaches published in the literature for implementing such "AER Generator" circuits. They differ on the way of handling event collisions coming from the array of neurons. One approach is based on detecting and discarding collisions, while the other incorporates arbitration for sequencing colliding events . The first approach is supposed to be simpler and faster, while the second is able to handle much higher event traffic. In this article we will concentrate on the second arbiter-based approach. Boahen has been publishing several techniques for implementing and improving the arbiter based approach. Originally, he proposed an arbitration squeme by rows, followed by a column arbitration. In this scheme, while one neuron was selected by the arbiters to transmit his event out of the chip, the rest of neurons in the array were

  5. Hexa-histidin tag position influences disulfide structure but not binding behavior of in vitro folded N-terminal domain of rat corticotropin-releasing factor receptor type 2a

    OpenAIRE

    Klose, Jana; Wendt, Norbert; Kubald, Sybille; Krause, Eberhard; Fechner, Klaus; Beyermann, Michael; Bienert, Michael; Rudolph, Rainer; Rothemund, Sven

    2004-01-01

    The oxidative folding, particularly the arrangement of disulfide bonds of recombinant extracellular N-terminal domains of the corticotropin-releasing factor receptor type 2a bearing five cysteines (C2 to C6), was investigated. Depending on the position of a His-tag, two types of disulfide patterns were found. In the case of an N-terminal His-tag, the disulfide bonds C2–C3 and C4–C6 were found, leaving C5 free, whereas the C-terminal position of the His-tag led to the disulfide pattern C2–C5 a...

  6. Using variable transformations to perform common event analysis

    International Nuclear Information System (INIS)

    Worrell, R.B.

    1977-01-01

    Any analytical method for studying the effect of common events on the behavior of a system is considered as being a form of common event analysis. The particular common events that are involved often represent quite different phenomena, and this has led to the development of different kinds of common event analysis. For example, common mode failure analysis, common cause analysis, critical location analysis, etc., are all different kinds of common event analysis for which the common events involved represent different phenomena. However, the problem that must be solved for each of these different kinds of common event analysis is essentially the same: Determine the effect of common events on the behavior of a system. Thus, a technique that is useful in achieving one kind of common event analysis is often useful in achieving other kinds of common event analysis

  7. Drug Rele