Sample records for release consistent distributed

  1. Consistency in Distributed Systems

    Kemme, Bettina; Ramalingam, Ganesan; Schiper, André; Shapiro, Marc; Vaswani, Kapil


    International audience; In distributed systems, there exists a fundamental trade-off between data consistency, availability, and the ability to tolerate failures. This trade-off has significant implications on the design of the entire distributed computing infrastructure such as storage systems, compilers and runtimes, application development frameworks and programming languages. Unfortunately, it also has significant, and poorly understood, implications for the designers and developers of en...

  2. Maintaining consistency in distributed systems

    Birman, Kenneth P.


    In systems designed as assemblies of independently developed components, concurrent access to data or data structures normally arises within individual programs, and is controlled using mutual exclusion constructs, such as semaphores and monitors. Where data is persistent and/or sets of operation are related to one another, transactions or linearizability may be more appropriate. Systems that incorporate cooperative styles of distributed execution often replicate or distribute data within groups of components. In these cases, group oriented consistency properties must be maintained, and tools based on the virtual synchrony execution model greatly simplify the task confronting an application developer. All three styles of distributed computing are likely to be seen in future systems - often, within the same application. This leads us to propose an integrated approach that permits applications that use virtual synchrony with concurrent objects that respect a linearizability constraint, and vice versa. Transactional subsystems are treated as a special case of linearizability.

  3. The consistency service of the ATLAS Distributed Data Management system

    Serfon, C; The ATLAS collaboration


    With the continuously increasing volume of data produced by ATLAS and stored on the WLCG sites, the probability of data corruption or data losses, due to software and hardware failures is increasing. In order to ensure the consistency of all data produced by ATLAS a Consistency Service has been developed as part of the DQ2 Distributed Data Management system. This service is fed by the different ATLAS tools, i.e. the analysis tools, production tools, DQ2 site services or by site administrators that report corrupted or lost files. It automatically corrects the errors reported and informs the users in case of irrecoverable file loss.

  4. The Consistency Service of the ATLAS Distributed Data Management system

    Serfon, C; The ATLAS collaboration


    With the continuously increasing volume of data produced by ATLAS and stored on the WLCG sites, the probability of data corruption or data losses, due to software and hardware failure is increasing. In order to ensure the consistency of all data produced by ATLAS a Consistency Service has been developed as part of the DQ2 Distributed Data Management system. This service is fed by the different ATLAS tools, i.e. the analysis tools, production tools, DQ2 site services or by site administrators that report corrupted or lost files. It automatically correct the errors reported and informs the users in case of irrecoverable file loss.

  5. Applying Soft Arc Consistency to Distributed Constraint Optimization Problems

    Matsui, Toshihiro; Silaghi, Marius C.; Hirayama, Katsutoshi; Yokoo, Makot; Matsuo, Hiroshi

    The Distributed Constraint Optimization Problem (DCOP) is a fundamental framework of multi-agent systems. With DCOPs a multi-agent system is represented as a set of variables and a set of constraints/cost functions. Distributed task scheduling and distributed resource allocation can be formalized as DCOPs. In this paper, we propose an efficient method that applies directed soft arc consistency to a DCOP. In particular, we focus on DCOP solvers that employ pseudo-trees. A pseudo-tree is a graph structure for a constraint network that represents a partial ordering of variables. Some pseudo-tree-based search algorithms perform optimistic searches using explicit/implicit backtracking in parallel. However, for cost functions taking a wide range of cost values, such exact algorithms require many search iterations. Therefore additional improvements are necessary to reduce the number of search iterations. A previous study used a dynamic programming-based preprocessing technique that estimates the lower bound values of costs. However, there are opportunities for further improvements of efficiency. In addition, modifications of the search algorithm are necessary to use the estimated lower bounds. The proposed method applies soft arc consistency (soft AC) enforcement to DCOP. In the proposed method, directed soft AC is performed based on a pseudo-tree in a bottom up manner. Using the directed soft AC, the global lower bound value of cost functions is passed up to the root node of the pseudo-tree. It also totally reduces values of binary cost functions. As a result, the original problem is converted to an equivalent problem. The equivalent problem is efficiently solved using common search algorithms. Therefore, no major modifications are necessary in search algorithms. The performance of the proposed method is evaluated by experimentation. The results show that it is more efficient than previous methods.

  6. Parton distributions based on a maximally consistent dataset

    Rojo, Juan


    The choice of data that enters a global QCD analysis can have a substantial impact on the resulting parton distributions and their predictions for collider observables. One of the main reasons for this has to do with the possible presence of inconsistencies, either internal within an experiment or external between different experiments. In order to assess the robustness of the global fit, different definitions of a conservative PDF set, that is, a PDF set based on a maximally consistent dataset, have been introduced. However, these approaches are typically affected by theory biases in the selection of the dataset. In this contribution, after a brief overview of recent NNPDF developments, we propose a new, fully objective, definition of a conservative PDF set, based on the Bayesian reweighting approach. Using the new NNPDF3.0 framework, we produce various conservative sets, which turn out to be mutually in agreement within the respective PDF uncertainties, as well as with the global fit. We explore some of the...

  7. Ball Speed and Release Consistency Predict Pitching Success in Major League Baseball.

    Whiteside, David; Martini, Douglas N; Zernicke, Ronald F; Goulet, Grant C


    Whiteside, D, Martini, DN, Zernicke, RF, and Goulet, GC. Ball speed and release consistency predict pitching success in Major League Baseball. J Strength Cond Res XX(X): 000-000, 2015-This study aimed to quantify how ball flight kinematics (i.e., ball speed and movement), release location, and variations therein relate to pitching success in Major League Baseball (MLB). One hundred ninety starting MLB pitchers met the inclusion criteria for this study. Ball trajectory information was collected for 76,000 pitches and inserted into a forward stepwise multiple regression model, which examined how (a) pitch selection, (b) ball speed, (c) ball movement (horizontal and lateral), (d) release location (horizontal and lateral), (e) variation in pitch speed, (f) variation in ball movement, and (g) variation in release location related to pitching success (as measured by fielding independent pitching-FIP). Pitch speed, release location variability, variation in pitch speed, and horizontal release location were significant predictors of FIP and, collectively, accounted for 24% of the variance in FIP. These findings suggest that (a) maximizing ball speed, (b) refining a consistent spatial release location, and (c) using varied pitch speeds should be primary foci for the pitching coach. However, between-pitcher variations underline how training interventions should be administered at the individual level, with consideration given to the pitcher's injury history. Finally, despite offering significant predictors of success, these three factors explained only 22% of the variance in FIP and should not be considered the only, or preeminent, indicators of a pitcher's effectiveness. Evidently, traditional pitching metrics only partly account for a pitcher's effectiveness, and future research is necessary to uncover the remaining contributors to success.

  8. Understanding and Improving the Performance Consistency of Distributed Computing Systems

    Yigitbasi, M.N.


    With the increasing adoption of distributed systems in both academia and industry, and with the increasing computational and storage requirements of distributed applications, users inevitably demand more from these systems. Moreover, users also depend on these systems for latency and throughput sens

  9. Understanding and Improving the Performance Consistency of Distributed Computing Systems

    Yigitbasi, M.N.


    With the increasing adoption of distributed systems in both academia and industry, and with the increasing computational and storage requirements of distributed applications, users inevitably demand more from these systems. Moreover, users also depend on these systems for latency and throughput sens

  10. Consistent energy barrier distributions in magnetic particle chains

    Laslett, O., E-mail: [Engineering and the Environment, University of Southampton, Southampton, SO16 7QF (United Kingdom); Ruta, S.; Chantrell, R.W. [Department of Physics, University of York, York YO10 5DD (United Kingdom); Barker, J. [Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan); Friedman, G. [Electrical and Computer Engineering Department, Drexel University, Philadelphia, PA 19104 (United States); Hovorka, O. [Engineering and the Environment, University of Southampton, Southampton, SO16 7QF (United Kingdom)


    We investigate long-time thermal activation behaviour in magnetic particle chains of variable length. Chains are modelled as Stoner–Wohlfarth particles coupled by dipolar interactions. Thermal activation is described as a hopping process over a multidimensional energy landscape using the discrete orientation model limit of the Landau–Lifshitz–Gilbert dynamics. The underlying master equation is solved by diagonalising the associated transition matrix, which allows the evaluation of distributions of time scales of intrinsic thermal activation modes and their energy representation. It is shown that as a result of the interaction dependence of these distributions, increasing the particle chain length can lead to acceleration or deceleration of the overall relaxation process depending on the initialisation procedure.

  11. The consistency service of the ATLAS distributed data management system

    Serfon, Cedric; Calfayan, Philippe; Duckeck, Guenter; Ebke, Johannes; Elmsheuser, Johannes; Legger, Federica; Mitterer, Christoph; Schaile, Dorothee; Walker, Rodney [LMU, Munich (Germany)


    With the continuously increasing volume of data (More than 50 PB) produced by ATLAS and stored on the WLCG sites, the probability of data corruption or data losses (for instance due to hardware failure) is increasing. With the current size of the disks, a pool crash that cannot be recovered typically represents O(10000) files. It is therefore important to have an automated service to recover these file losses: this is the role of the Consistency Service. This service is used by various ATLAS tools (Analysis tools, Production tools, DQ2 Site Services..) or by site administrators that report corrupted or lost files. It automatically recovers lost files or corrects the errors reported and informs the users in case of irrecoverable file loss.

  12. Managing Consistency Anomalies in Distributed Integrated Databases with Relaxed ACID Properties

    Frank, Lars; Ulslev Pedersen, Rasmus


    In central databases the consistency of data is normally implemented by using the ACID (Atomicity, Consistency, Isolation and Durability) properties of a DBMS (Data Base Management System). This is not possible if distributed and/or mobile databases are involved and the availability of data also...... has to be optimized. Therefore, we will in this paper use so called relaxed ACID properties across different locations. The objective of designing relaxed ACID properties across different database locations is that the users can trust the data they use even if the distributed database temporarily...... been committed and completed, the execution has the consistency property. The above definition of the consistency property is not useful in distributed databases with relaxed ACID properties because such a database is almost always inconsistent. In the following, we will use the concept Consistency...

  13. Stationary self-consistent distributions for a charged particle beam in the longitudinal magnetic field

    Drivotin, O. I.; Ovsyannikov, D. A.


    A review of analytical solutions of the Vlasov equation for a beam of charged particles is given. These results are analyzed on the basis of a unified approach developed by the authors. In the context of this method, a space of integrals of motion is introduced in which the integrals of motion of particles are considered as coordinates. In this case, specifying a self-consistent distribution is reduced to defining a distribution density in this space. This approach allows us to simplify the construction and analysis of different self-consistent distributions. In particular, it is possible, in some cases, to derive new solutions by considering linear combinations of well-known solutions. This approach also makes it possible in many cases to give a visual geometric representation of self-consistent distributions in the space of integrals of motion.

  14. A reliable p ower management scheme for consistent hashing based distributed key value storage systems#

    Nan-nan ZHAO; Ji-guang WAN; Jun WANG; Chang-sheng XIE


    Distributed key value storage systems are among the most important types of distributed storage systems currently deployed in data centers. Nowadays, enterprise data centers are facing growing pressure in reducing their power consumption. In this paper, we propose GreenCHT, a reliable power management scheme for consistent hashing based distributed key value storage systems. It consists of a multi-tier replication scheme, a reliable distributed log store, and a predictive power mode scheduler (PMS). Instead of randomly placing replicas of each object on a number of nodes in the consistent hash ring, we arrange the replicas of objects on nonoverlapping tiers of nodes in the ring. This allows the system to fall in various power modes by powering down subsets of servers while not violating data availability. The predictive PMS predicts workloads and adapts to load fluctuation. It cooperates with the multi-tier replication strategy to provide power proportionality for the system. To ensure that the reliability of the system is maintained when replicas are powered down, we distribute the writes to standby replicas to active servers, which ensures failure tolerance of the system. GreenCHT is implemented based on Sheepdog, a distributed key value storage system that uses consistent hashing as an underlying distributed hash table. By replaying 12 typical real workload traces collected from Microsoft, the evaluation results show that GreenCHT can provide significant power savings while maintaining a desired performance. We observe that GreenCHT can reduce power consumption by up to 35%–61%.

  15. Towards an Information Model of Consistency Maintenance in Distributed Interactive Applications

    Xin Zhang


    Full Text Available A novel framework to model and explore predictive contract mechanisms in distributed interactive applications (DIAs using information theory is proposed. In our model, the entity state update scheme is modelled as an information generation, encoding, and reconstruction process. Such a perspective facilitates a quantitative measurement of state fidelity loss as a result of the distribution protocol. Results from an experimental study on a first-person shooter game are used to illustrate the utility of this measurement process. We contend that our proposed model is a starting point to reframe and analyse consistency maintenance in DIAs as a problem in distributed interactive media compression.

  16. Numerical simulations of self-consistently generated κ distributions in the solar wind and solar corona

    Randol, B. M.; Christian, E. R.


    In a previous study (Randol and Christian, submitted to JGR, April 2014), numerical simulations of protons and anti-protons obeying Coulomb's law provided key insight into the self-consistent generation of κ distributions in space plasmas. In that study, the velocity distribution function (VDF) first formed a tail with the common spectral index of -5 and then gradually became a κ-r distribution, with κ = 1.5, corresponding to the common spectrum. The form of this distribution was found to relate to the electric field distribution function (EDF). These results were robust to a range of initialized densities and thermal speeds; however, this range of parameters did not include values close to those of the solar wind at 1 AU. Here we report on simulations of the same type but for a broader range of parameters, including those of the solar wind and corona. Our earliest findings indicate a lack of consistency in the VDF with the common spectrum, the cause of which again lies in the EDF. The results are instructive for understanding the solar wind ion VDF core and tail, as well as for κ distributed plasmas in general.

  17. A Permutation Gigantic Issues in Mobile Real Time Distributed Database : Consistency & Security

    Gyanendra Kr. Gupta


    Full Text Available Several shape of Information System are broadly used in a variety of System Models. With the rapid development of computer network, Information System users concern more about data sharing in networks. In conventional relational database, data consistency was controlled by consistency control mechanism when a data object is locked in a sharing mode, other transactions can only read it, but can not update it. If the traditional consistency control method has been used yet, the system’s concurrency will be inadequately influenced. So there are many new necessities for the consistency control and security in Mobile Real Time Distributed Database (MRTDDB. The problem not limited only to type of data (e.g. mobile or real-time databases. There are many aspects of data consistency problems in MRTDDB, such as inconsistency between characteristic and type of data; the nconsistency of topological relations after objects has been modified. In this paper, many cases of consistency are discussed. As the mobile computing becomes well-liked and the database grows with information sharing security is a big issue for researchers. Mutually both Consistency and Security of data is a big confront for esearchers because whenever the data is not consistent and secure no maneuver on the data (e.g. transaction is productive. It becomes more and more crucial when the transactions are used in on-traditional environment like Mobile, Distributed, Real Time and Multimedia databases. In this paper we raise the different aspects and analyze the available solution for consistency and security of databases. Traditional Database Security has focused primarily on creating user accounts and managing user rights to database objects. But in the mobility and drifting computing uses this database creating a new prospect for research. The wide spread use of databases over the web, heterogeneous client-server architectures,application servers, and networks creates a critical need to

  18. Consistency and Security in Mobile Real Time Distributed Database (MRTDDB): A Combinational Giant Challenge

    Gupta, Gyanendra Kr.; Sharma, A. K.; Swaroop, Vishnu


    Many type of Information System are widely used in various fields. With the hasty development of computer network, Information System users care more about data sharing in networks. In traditional relational database, data consistency was controlled by consistency control mechanism when a data object is locked in a sharing mode, other transactions can only read it, but can not update it. If the traditional consistency control method has been used yet, the system's concurrency will be inadequately influenced. So there are many new necessities for the consistency control and security in MRTDDB. The problem not limited only to type of data (e.g. mobile or real-time databases). There are many aspects of data consistency problems in MRTDDB, such as inconsistency between attribute and type of data; the inconsistency of topological relations after objects has been modified. In this paper, many cases of consistency are discussed. As the mobile computing becomes well liked and the database grows with information sharing security is a big issue for researchers. Consistency and Security of data is a big challenge for researchers because when ever the data is not consistent and secure no maneuver on the data (e.g. transaction) is productive. It becomes more and more crucial when the transactions are used in non-traditional environment like Mobile, Distributed, Real Time and Multimedia databases. In this paper we raise the different aspects and analyze the available solution for consistency and security of databases. Traditional Database Security has focused primarily on creating user accounts and managing user privileges to database objects. But in the mobility and nomadic computing uses these database creating a new opportunities for research. The wide spread use of databases over the web, heterogeneous client-server architectures, application servers, and networks creates a critical need to amplify this focus. In this paper we also discuss an overview of the new and old

  19. Self-Consistent Fokker-Planck Treatment Of Particle Distributions in Astrophysical Plasmas

    Nayakshin, S; Nayakshin, Sergei; Melia, Fulvio


    High-energy, multi-component plasmas in which pair creation and annihilation, lepton-lepton scattering, lepton-proton scattering, and Comptonization all contribute to establishing the particle and photon distributions, are present in a broad range of compact astrophysical objects. Earlier work has included much of the microphysics needed to account for electron-photon and electron-proton interactions, but little has been done to handle the redistribution of the particles as a result of their Coulomb interaction with themselves in an arbitrary case. Our goal here is to use a Fokker-Planck approach in order to develop a fully self-consistent theory for the interaction of arbitrarily distributed particles and radiation to arrive at an accurate representation of the high-energy plasma in these sources. We conduct several tests representative of two dominant segments of parameter space and discuss physical implications of the non-Maxwellian distribution function. Approximate analytical forms for the electron distr...

  20. Consistency of change point estimators for symmetrical stable distribution with parameters shift

    SHI XiaoPing; MIAO BaiQi; GE ChunLei


    Assume that the characteristic index α of stable distribution satisfies 1<α<2, and that the distribution is symmetrical about its mean. We consider the change point estimators for stable distribution with a or scale parameter β shift. For the one case that mean is a known constant, if or β changes, then density function will change too. To this end, we suppose the kernel estimation for a change point. For the other case that mean is an unknown constant, we suppose to apply empirical characteristic function to estimate the change-point location. In the two cases, we consider the consistency and strong convergence rate of estimators. Furthermore, we consider the mean shift case. If mean changes, then corresponding characteristic function will change too. To this end, we also apply empirical characteristic function to estimate change point. We obtain the similar convergence rate. Finally, we consider its application on the detection of mean shift in financial market.

  1. Are the distributions of Fast Radio Burst properties consistent with a cosmological population?

    Caleb, M; Bailes, M; Barr, E D; Hunstead, R W; Keane, E F; Ravi, V; van Straten, W


    High time resolution radio surveys over the last few years have discovered a population of millisecond-duration transient bursts called Fast Radio Bursts (FRBs), which remain of unknown origin. FRBs exhibit dispersion consistent with propagation through a cold plasma and dispersion measures indicative of an origin at cosmological distances. In this paper we perform Monte Carlo simulations of a cosmological population of FRBs, based on assumptions consistent with observations of their energy distribution, their spatial density as a function of redshift and the properties of the interstellar and intergalactic media. We examine whether the dispersion measures, fluences, inferred redshifts, signal-to-noises and effective widths of known FRBs are consistent with a cosmological population. Statistical analyses indicate that at least 50 events at Parkes are required to distinguish between a constant co-moving FRB density, and a FRB density that evolves with redshift like the cosmological star formation rate density.

  2. Wave solutions of ion cyclotron heated plasmas with self-consistent velocity distributions in a tokamak

    Lee, Jungpyo; Wright, John; Bonoli, Paul; Harvey, Robert


    We describe a numerical model for the propagation and absorption of ion cyclotron waves in a tokamak with a non-Maxwellian velocity space distribution function. The non-Maxwellian distribution is calculated by solving Maxwell's equations and the Fokker-Plank equation self-consistently. This approach will be useful to interpret measurements of minority hydrogen tail formation during ICRF heating experiments in Alcator C-Mod. To couple the Maxwell equation solver with Fokker-Plank equation solver, the quasilinear diffusion coefficients for the fundamental ion cyclotron absorption and the first harmonic absorption are calculated. In a previous study, the all-orders spectral algorithm wave solver (AORSA) was coupled with the Fokker-Plank code (CQL3D) to find the self-consistent non-Maxwellian distribution. We derive the modified quasilinear diffusion coefficients for the finite Larmor radius (FLR) approximation using a significantly faster wave solver (TORIC) following the approach by Jaeger. The coupled TORIC-CQL3D model will be compared against results from AORSA-CQL3D in order to verify the accuracy of the reduced FLR physics in TORIC. Work supported by US Department of Energy Contract No. DE-FC02-01ER54648.

  3. Longitudinal halo in beam bunches with self-consistent 6-D distributions

    Gluckstern, R. L.; Fedotov, A. V.; Kurennoy, S. S.; Ryne, R. D.


    We have explored the formation of longitudinal and transverse halos in 3-D axisymmetric beam bunches by starting with a self-consistent 6-D phase space distribution. Stationary distributions allow us to study the halo development mechanism without being obscured by beam redistribution and its effect on halo formation. The beam is then mismatched longitudinally and/or transversely, and we explore the rate, intensity and spatial extent of the halos which form, as a function of the beam charge and the mismatches. We find that the longitudinal halo forms first because the longitudinal tune depression is more severe than the transverse one for elongated bunches and conclude that it plays a major role in halo formation.

  4. Are range-size distributions consistent with species-level heritability?

    Borregaard, Michael Krabbe; Gotelli, Nicholas; Rahbek, Carsten


    been that it is not compatible with the observed shape of present-day species range-size distributions (SRDs), a claim that has never been tested. To assess this claim, we used forward simulation of range-size evolution in clades with varying degrees of range-size heritability, and compared the output...... of three different models to the range-size distribution of the South American avifauna. Although there were differences among the models, a moderate-to-high degree of range-size heritability consistently leads to SRDs that were similar to empirical data. These results suggest that range-size heritability......The concept of species-level heritability is widely contested. Because it is most likely to apply to emergent, species-level traits, one of the central discussions has focused on the potential heritability of geographic range size. However, a central argument against range-size heritability has...

  5. Halo Formation in 3-D Bunches with Self-Consistent Stationary Distributions

    Fedotov, A. V.; Gluckstern, R. L.; Kurennoy, S. S.; Ryne, R. D.


    We have constructed, analytically and numerically, a new class of self-consistent 6-D phase space stationary distributions. The beam is then mismatched longitudinally and/or transversely, and we explore the formation of longitudinal and transverse halos in 3-D axisymmetric beam bunches. The longitudinal phase space clearly shows the typical "peanut" diagram observed in 2-D calculations. We find that the longitudinal halo forms first for comparable longitudinal and transverse mismatches because the longitudinal tune depression is more severe than the transverse one for elongated bunches. Of particular importance is the coupling between longitudinal and transverse motion and its effect on halo formation.

  6. Consistency of change point estimators for symmetrical stable distribution with parameters shift


    Assume that the characteristic indexαof stable distribution satisfies 1<α<2,and that the distribution is symmetrical about its mean.We consider the change point estimators for stable distribution withαor scale parameterβshift.For the one case that mean is a known constant,ifαorβchanges,then density function will change too.To this end,we suppose the kernel estimation for a change point.For the other case that mean is an unknown constant,we suppose to apply empirical characteristic function to estimate the change-point location.In the two cases,we consider the consistency and strong convergence rate of estimators.Furthermore,we consider the mean shift case.If mean changes,then corresponding characteristic function will change too.To this end,we also apply empirical characteristic function to estimate change point.We obtain the similar convergence rate.Finally,we consider its application on the detection of mean shift in financial market.

  7. Integrated Scheduling of Production and Distribution with Release Dates and Capacitated Deliveries

    Xueling Zhong


    Full Text Available This paper investigates an integrated scheduling of production and distribution model in a supply chain consisting of a single machine, a customer, and a sufficient number of homogeneous capacitated vehicles. In this model, the customer places a set of orders, each of which has a given release date. All orders are first processed nonpreemptively on the machine and then batch delivered to the customer. Two variations of the model with different objective functions are studied: one is to minimize the arrival time of the last order plus total distribution cost and the other is to minimize total arrival time of the orders plus total distribution cost. For the former one, we provide a polynomial-time exact algorithm. For the latter one, due to its NP-hard property, we provide a heuristic with a worst-case ratio bound of 2.

  8. Halo formation in spheroidal bunches with self-consistent stationary distributions

    Fedotov, A.V.; Gluckstern, R.L. [Univ. of Maryland, College Park, MD (United States); Kurennoy, S.S.; Ryne, R.D. [Los Alamos National Lab., NM (United States)


    A new class of self-consistent 6-D phase space stationary distributions is constructed both analytically and numerically. The beam is then mismatched longitudinally and/or transversely, and the authors explore the beam stability and halo formation for the case of 3-D axisymmetric beam bunches using particle-in-cell simulations. They concentrate on beams with bunch length-to-width ratios varying from 1 to 5, which covers the typical range of the APT linac parameters. They find that the longitudinal halo forms first for comparable longitudinal and transverse mismatches. An interesting coupling phenomenon -- a longitudinal or transverse halo is observed even for very small mismatches if the mismatch in the other plane is large -- is discovered.

  9. Ground truth delineation for medical image segmentation based on Local Consistency and Distribution Map analysis.

    Cheng, Irene; Sun, Xinyao; Alsufyani, Noura; Xiong, Zhihui; Major, Paul; Basu, Anup


    Computer-aided detection (CAD) systems are being increasingly deployed for medical applications in recent years with the goal to speed up tedious tasks and improve precision. Among others, segmentation is an important component in CAD systems as a preprocessing step to help recognize patterns in medical images. In order to assess the accuracy of a CAD segmentation algorithm, comparison with ground truth data is necessary. To-date, ground truth delineation relies mainly on contours that are either manually defined by clinical experts or automatically generated by software. In this paper, we propose a systematic ground truth delineation method based on a Local Consistency Set Analysis approach, which can be used to establish an accurate ground truth representation, or if ground truth is available, to assess the accuracy of a CAD generated segmentation algorithm. We validate our computational model using medical data. Experimental results demonstrate the robustness of our approach. In contrast to current methods, our model also provides consistency information at distributed boundary pixel level, and thus is invariant to global compensation error.

  10. A novel approach to kinetic energy release distribution and charge state distribution measurements

    Lee, Kaidee [National Synchrotron Radiation Research Center, Hsinchu 30077, Taiwan (China)]. E-mail:


    When a swarm of ions are accelerated by a pulsed electric field for a common duration before entering an electrostatically dispersive energy analyzer, they will be sorted according to their charge-to-mass ratio q/m. In other words, the apparent kinetic energy upon which an ion will be registered in an apparent 'energy' spectrum thus obtained is proportional to its q/m ratio. For ions of a fixed mass m, the apparent energy spectrum becomes a charge state distribution spectrum. For ions of a fixed charge q, the apparent energy spectrum becomes a mass spectrum. In essence, an energy analyzer becomes both a charge sorter and a mass spectrometer when operated in this mode. In addition, when applied to the detection of photofragment ions, this technique will be able to yield information on the kinetic energy release distribution of the underlying dissociation events.

  11. The influence of spray-drying parameters on phase behavior, drug distribution, and in vitro release of injectable microspheres for sustained release.

    Meeus, Joke; Lenaerts, Maité; Scurr, David J; Amssoms, Katie; Davies, Martyn C; Roberts, Clive J; Van Den Mooter, Guy


    For ternary solid dispersions, it is indispensable to characterize their structure, phase behavior, and the spatial distribution of the dispersed drug as this might influence the release profile and/or stability of these formulations. This study shows how formulation (feed concentration) and process (feed rate, inlet air temperature, and atomizing air pressure) parameters can influence the characteristics of ternary spray-dried solid dispersions. The microspheres considered here consist of a poly(lactic-co-glycolic acid) (PLGA) surface layer and an underlying polyvinylpyrrolidone (PVP) phase. A poorly soluble active pharmaceutical ingredient (API) was molecularly dispersed in this matrix. Differences were observed in component miscibility, phase heterogeneity, particle size, morphology, as well as API surface coverage for selected spray-drying parameters. Observed differences are likely because of changes in the droplet generation, evaporation, and thus particle formation processes. However, varying particle characteristics did not influence the drug release of the formulations studied, indicating the robustness of this approach to produce particles of consistent drug release characteristics. This is likely because of the fact that the release is dominated by diffusion from the PVP layer through pores in the PLGA surface layer and that observed differences in the latter have no influence on the release.

  12. Southern San Andreas Fault seismicity is consistent with the Gutenberg-Richter magnitude-frequency distribution

    Page, Morgan T.; Felzer, Karen


    The magnitudes of any collection of earthquakes nucleating in a region are generally observed to follow the Gutenberg-Richter (G-R) distribution. On some major faults, however, paleoseismic rates are higher than a G-R extrapolation from the modern rate of small earthquakes would predict. This, along with other observations, led to formulation of the characteristic earthquake hypothesis, which holds that the rate of small to moderate earthquakes is permanently low on large faults relative to the large-earthquake rate (Wesnousky et al., 1983; Schwartz and Coppersmith, 1984). We examine the rate difference between recent small to moderate earthquakes on the southern San Andreas fault (SSAF) and the paleoseismic record, hypothesizing that the discrepancy can be explained as a rate change in time rather than a deviation from G-R statistics. We find that with reasonable assumptions, the rate changes necessary to bring the small and large earthquake rates into alignment agree with the size of rate changes seen in epidemic-type aftershock sequence (ETAS) modeling, where aftershock triggering of large earthquakes drives strong fluctuations in the seismicity rates for earthquakes of all magnitudes. The necessary rate changes are also comparable to rate changes observed for other faults worldwide. These results are consistent with paleoseismic observations of temporally clustered bursts of large earthquakes on the SSAF and the absence of M greater than or equal to 7 earthquakes on the SSAF since 1857.

  13. Consistent empirical physical formula construction for recoil energy distribution in HPGe detectors using artificial neural networks

    Akkoyun, Serkan


    The gamma-ray tracking technique is one of the highly efficient detection method in experimental nuclear structure physics. On the basis of this method, two gamma-ray tracking arrays, AGATA in Europe and GRETA in the USA, are currently being developed. The interactions of neutrons in these detectors lead to an unwanted background in the gamma-ray spectra. Thus, the interaction points of neutrons in these detectors have to be determined in the gamma-ray tracking process in order to improve photo-peak efficiencies and peak-to-total ratios of the gamma-ray peaks. Therefore, the recoil energy distributions of germanium nuclei due to inelastic scatterings of 1-5 MeV neutrons were obtained both experimentally and using artificial neural networks. Also, for highly nonlinear detector response for recoiling germanium nuclei, we have constructed consistent empirical physical formulas (EPFs) by appropriate layered feed-forward neural networks (LFNNs). These LFNN-EPFs can be used to derive further physical functions whic...

  14. Drug release-modulating mechanism of hydrophilic hydroxypropylmethylcellulose matrix tablets: distribution of atoms and carrier and texture analysis.

    Park, Jun-Bom; Lim, Jisung; Kang, Chin-Yang; Lee, Beom-Jin


    Although release profiles of drug from hydrophilic matrices have been well recognized, the visual distribution of hydroxypropylmethylcellulose (HPMC) and atoms inside of internal structures of hydrophilic HPMC matrices has not been characterized. In this paper, drug release mechanism from HPMC matrix tablet was investigated based on the release behaviors of HPMC, physical properties of gelled HPMC tablet and atomic distributions of formulation components using diverse instruments. A matrix tablet consisting of hydroxypropyl methylcellulose (HPMC 6, 4,000 and 100,000 mPa·s), chlorpheniramine maleate (CPM) as a model and fumed silicon dioxide (Aerosil(®) 200) was prepared via direct compression. The distribution of atoms and HPMC imaging were characterized using scanning electron microscope (SEM)/ energy-dispersive X-ray spectroscopy (EDX), and near-infrared (NIR) analysis, respectively as a function of time. A texture analyzer was also used to characterize the thickness and maintenance of gel layer of HPMC matrix tablet. The HPMC matrix tablets showed Higuchi release kinetics with no lag time against the square root of time. High viscosity grades of HPMC gave retarded release rate because of the greater swelling and gel thickness as characterized by texture analyzer. According to the NIR imaging, low-viscosity-grade HPMC (6 mPa·s) quickly leached out onto the surface of the tablet, while the high-viscosity-grade HPMC (4000 mPa·s) formed much thicker gel layer around the tablet and maintained longer via slow erosion, resulting in retarded drug release. The atomic distribution of the drug (chlorine, carbon, oxygen), HPMC (carbon, oxygen) and silicon dioxide (silica, oxygen) and NIR imaging of HPMC corresponded with the dissolution behaviors of drug as a function of time. The use of imaging and texture analyses could be applicable to explain the release- modulating mechanism of hydrophilic HPMC matrix tablets.

  15. QuickLex: A Fast Algorithm for Consistent Global States Enumeration of Distributed Computations

    Chang, Yen-Jung; Vijay K Garg


    Verifying the correctness of executions of concurrent and distributed programs is difficult because they show nondeterministic behavior due to different process scheduling order. Predicate detection can alleviate this problem by predicting whether the user-specified condition (predicate) could have become true in any global state of the given concurrent or distributed computation. The method is predictive because it generates inferred global states from the observed execution path and then ch...

  16. Bid distribution derived from consistent mixed strategy in lowest unique bid auction

    Zhao, Yinan; Chen, Qinghua; Wang, Yougui


    The Lowest Unique Bid Auction (LUBA) booms recently through the Internet. A typical distribution pattern of bid price in this reverse auction has been found and needs to be interpreted. The distribution curve is a decreasing one whose slope has a close relationship with the number of agents participating in the auction. To explain this stylized fact, we develop a model assuming that agents prefer to bid on the price at which the probability of winning is higher. The bid distributions of actual auctions with the number of agents less than 200 can be fitted very well using the parameters for the value of items and the number of bids. When this number becomes larger, however, a deviation occurs between prediction and empirical data, which can be adjusted by introducing cognitive illusion of the bid number.

  17. A consistent model for \\pi N transition distribution amplitudes and backward pion electroproduction

    Lansberg, J P; Semenov-Tian-Shansky, K; Szymanowski, L


    The extension of the concept of generalized parton distributions leads to the introduction of baryon to meson transition distribution amplitudes (TDAs), non-diagonal matrix elements of the nonlocal three quark operator between a nucleon and a meson state. We present a general framework for modelling nucleon to pion ($\\pi N$) TDAs. Our main tool is the spectral representation for \\pi N TDAs in terms of quadruple distributions. We propose a factorized Ansatz for quadruple distributions with input from the soft-pion theorem for \\pi N TDAs. The spectral representation is complemented with a D-term like contribution from the nucleon exchange in the cross channel. We then study backward pion electroproduction in the QCD collinear factorization approach in which the non-perturbative part of the amplitude involves \\pi N TDAs. Within our two component model for \\pi N TDAs we update previous leading-twist estimates of the unpolarized cross section. Finally, we compute the transverse target single spin asymmetry as a fu...

  18. Predicting intragranular misorientation distributions in polycrystalline metals using the viscoplastic self-consistent formulation

    Zecevic, Miroslav; Pantleon, Wolfgang; A. Lebensohn, Ricardo


    In a recent paper, we reported the methodology to calculate intragranular fluctuations in the instantaneous lattice rotation rates in polycrystalline materials within the mean-field viscoplastic self-consistent (VPSC) model. This paper is concerned with the time integration and subsequent use of ...

  19. Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma

    Lange-Asschenfeldt, Susanne; Babilli, Jasmin; Beyer, Marc; Ríus-Diaz, Francisca; González, Salvador; Stockfleth, Eggert; Ulrich, Martina


    Reflectance confocal microscopy (RCM) represents a noninvasive imaging technique that has previously been used for characterization of mycosis fungoides (MF) in a pilot study. We aimed to test the applicability of RCM for diagnosis and differential diagnosis of MF in a clinical study. A total of 39 test sites of 15 patients with a biopsy-proven diagnosis of either MF, parapsoriasis, Sézary syndrome, or lymphomatoid papulosis were analyzed for presence and absence of RCM features of MF. Cochran and Chi2 analysis were applied to test the concordance between investigators and the distribution of RCM features, respectively. For selected parameters, the Cochran analysis showed good concordance between investigators. Inter-observer reproducibility was highest for junctional atypical lymphocytes, architectural disarray, and spongiosis. Similarly, Chi2 analysis demonstrated that selected features were present at particularly high frequency in individual skin diseases, with values ranging from 73% to 100% of all examined cases.

  20. The distribution in lunar soil of carbon released by pyrolysis

    Desmarais, D. J.; Hayes, J. M.; Meinschein, W. G.


    The carbon contents of various lunar soil particle types and sieve fractions of Apollo 15 and 16 samples have been determined by the pyrolysis method. The mineral, glass, and high-grade breccia fragments in the soils examined contain relatively low amounts of carbon (approximately 8, 25, and 25 microg C/g sample respectively in 149-250 micron grains). Most low-grade breccias and all agglutinates examined have high carbon contents (approximately 52 and 80 microg C/g sample respectively), and agglutinate abundance is indicative of the carbon content and maturity of a soil. The distribution of carbon with respect to particle size in mature soils generally reveals a minimum in carbon content at about 100 micron particle diameter. At smaller particle diameters, carbon content is directly proportional to particle surface area and therefore increases with the ratio (surface area)/(particle mass). A model relating the cycle of comminution and aggregation of soil particles to the redistribution of surface implanted carbon is developed.

  1. Distribution and release of 2,4,5-trichlorobiphenyl in ice

    Guo-xia Pei


    Full Text Available The distribution of persistent organic pollutants (POPs in ice and the release of POPs from ice during ice melting have an important influence on the eco-environment and water quality of a river. Through laboratory simulation experiments, the distribution and release of 2,4,5-trichlorobiphenyl (PCB29 in ice and the partition coefficients of PCB29 in ice water at different temperatures, concentrations, and pH levels were studied. The results showed that, at different temperatures and concentrations, the concentration of PCB29 in ice increased progressively with depth. The modes of release of different concentrations of PCB29 from ice were obtained. A large amount of PCB29 was released rapidly in the first melting period, and then the remaining PCB29 was released uniformly. The pH value dominated both the distribution and late release of PCB29 in ice. In ice water, at different temperatures, concentrations, and pH levels, the majority of PCB29 entered the water, and a lesser amount remained in the ice. Finally, laboratory experiment results were verified with field investigations. A theoretical framework is provided by this research of the behavior of POPs in ice under different environmental conditions, but a more quantitative understanding of the behavior of POPs in ice will need to be developed through further laboratory studies combined with field investigations.

  2. Effect on Landau damping rates for a non-Maxwellian distribution function consisting of two electron populations

    M.N.S.Qureshi; S.Sehar; H.A.Shah; J.B.Cao


    In many physical situations where a laser or electron beam passes through a dense plasma,hot low-density electron populations can be generated,resulting in a particle distribution function consisting of a dense cold population and a small hot population.Presence of such low-density electron distributions can alter the wave damping rate.A kinetic model is employed to study the Landau damping of Langmuir waves when a small hot electron population is present in the dense cold electron population with non-Maxwellian distribution functions.Departure of plasma from Maxwellian distributions significantly alters the damping rates as compared to the Maxwellian plasma.Strong damping is found for highly non-Maxwellian distributions as well as plasmas with a higher density and hot electron population.Existence of weak damping is also established when the distribution contains broadened flat tops at the low energies or tends to be Maxwellian.These results may be applied in both experimental and space physics regimes.

  3. Nonlinear development of stimulated Raman scattering from electrostatic modes excited by self-consistent non-Maxwellian velocity distributions.

    Yin, L; Daughton, W; Albright, B J; Bezzerides, B; DuBois, D F; Kindel, J M; Vu, H X


    The parametric coupling involving backward stimulated scattering of a laser and electron beam acoustic modes (BAM) is described as observed in particle-in-cell (PIC) simulations. The BAM modes evolve from Langmuir waves (LW) as the electron velocity distribution is nonlinearly modified to be non-Maxwellian by backward stimulated Raman scattering (BSRS). With a marginal damping rate, BAM can be easily excited and allow an extended chirping in frequency to occur as later SRS pulses encounter modified distributions. Coincident with the emergence of this non-Maxwellian distribution is a rapid increase in BSRS reflectivities with laser intensities. Both the reflectivity scaling with laser intensity and the observed spectral features from PIC simulations are consistent with recent Trident experiments.

  4. Effects of sulfate on heavy metal release from iron corrosion scales in drinking water distribution system.

    Sun, Huifang; Shi, Baoyou; Yang, Fan; Wang, Dongsheng


    Trace heavy metals accumulated in iron corrosion scales within a drinking water distribution system (DWDS) could potentially be released to bulk water and consequently deteriorate the tap water quality. The objective of this study was to identify and evaluate the release of trace heavy metals in DWDS under changing source water conditions. Experimental pipe loops with different iron corrosion scales were set up to simulate the actual DWDS. The effects of sulfate levels on heavy metal release were systemically investigated. Heavy metal releases of Mn, Ni, Cu, Pb, Cr and As could be rapidly triggered by sulfate addition but the releases slowly decreased over time. Heavy metal release was more severe in pipes transporting groundwater (GW) than in pipes transporting surface water (SW). There were strong positive correlations (R(2) > 0.8) between the releases of Fe and Mn, Fe and Ni, Fe and Cu, and Fe and Pb. When switching to higher sulfate water, iron corrosion scales in all pipe loops tended to be more stable (especially in pipes transporting GW), with a larger proportion of stable constituents (mainly Fe3O4) and fewer unstable compounds (β-FeOOH, γ-FeOOH, FeCO3 and amorphous iron oxides). The main functional iron reducing bacteria (IRB) communities were favorable for the formation of Fe3O4. The transformation of corrosion scales and the growth of sulfate reducing bacteria (SRB) accounted for the gradually reduced heavy metal release with time. The higher metal release in pipes transporting GW could be due to increased Fe6(OH)12CO3 content under higher sulfate concentrations.

  5. Diet, abundance and distribution as indices of turbot ( Psetta maxima L.) release habitat suitability

    Sparrevohn, Claus Reedtz; Støttrup, Josianne


    , natural abundance, and depth distribution within the habitats. A marked difference was found among habitats in the timing of the diet change from the suboptimal exoskeleton carrying prey items such as crustaceans to fish. The habitat where the wild turbot had the lowest occurrence of fish in their diet...... was also the habitat with the highest natural abundance of age-0 individuals and the deepest distribution of wild turbot. This was the habitat where released turbot grew more slowly than in the other habitats, which indicate that the diet and depth distribution of wild turbot may provide good indicators...

  6. Essential iOS Build and Release A Comprehensive Guide to Building, Packaging, and Distribution

    Roche, Ron


    Frustrated by the requirements for testing and distributing your iOS app? You're not alone. This concise book takes you step by step through the maze of certification and provisioning processes that have to happen before, during, and after development. You'll learn what's required to sign certificates, test your app on iOS devices, and release the finished product to the App Store. Whether you're a developer looking to spend more time coding and less time figuring out how to install your application, or a release engineer responsible for producing reliable builds, this guide will help you su

  7. Release and distribution of Lilioceris cheni (Coleoptera: Chrysomelidae), a biological control agent of air potato (Dioscorea bulbilfera: Dioscoreaceae), in Florida

    From 2012 to 2015, 429,668 Lilioceris cheni Gressit and Kimoto (Coleoptera: Chrysomelidae) were released in Florida for biological control of air potato [Dioscorea bulbilfera L. (Dioscoreaceae)]. The spatial distribution of releases was highly aggregated, with several areas of high density releases ...

  8. The problem of a self-consistent description of the equilibrium distribution of particles in three states of aggregation

    Tovbin, Yu. K.


    The possibility of unified self-consistent calculations of equilibrium distributions of molecules in three states of aggregation within the framework of the lattice gas model is considered. The corresponding approach was generalized to arbitrary pressures with including the compressibility of lattice structures. Closed equations were obtained for calculating thermodynamic functions (including an equation for the chemical potential of mixture components) in the continuum quasi-chemical approximation. Their use ensures equally accurate calculations of interphase equilibria in gas-liquid-solid systems and the determination of the triple and critical points. Possibilities for simplifying the equations by passing to the effective pair interaction potential, which takes into account averaged vibrations and volume accessible to the translational motion of molecules of commensurate sizes, are considered.

  9. Screen-Space Normal Distribution Function Caching for Consistent Multi-Resolution Rendering of Large Particle Data

    Ibrahim, Mohamed


    Molecular dynamics (MD) simulations are crucial to investigating important processes in physics and thermodynamics. The simulated atoms are usually visualized as hard spheres with Phong shading, where individual particles and their local density can be perceived well in close-up views. However, for large-scale simulations with 10 million particles or more, the visualization of large fields-of-view usually suffers from strong aliasing artifacts, because the mismatch between data size and output resolution leads to severe under-sampling of the geometry. Excessive super-sampling can alleviate this problem, but is prohibitively expensive. This paper presents a novel visualization method for large-scale particle data that addresses aliasing while enabling interactive high-quality rendering. We introduce the novel concept of screen-space normal distribution functions (S-NDFs) for particle data. S-NDFs represent the distribution of surface normals that map to a given pixel in screen space, which enables high-quality re-lighting without re-rendering particles. In order to facilitate interactive zooming, we cache S-NDFs in a screen-space mipmap (S-MIP). Together, these two concepts enable interactive, scale-consistent re-lighting and shading changes, as well as zooming, without having to re-sample the particle data. We show how our method facilitates the interactive exploration of real-world large-scale MD simulation data in different scenarios.

  10. Empirical phylogenies and species abundance distributions are consistent with pre-equilibrium dynamics of neutral community models with gene flow

    Bonnet-Lebrun, Anne-Sophie


    Community characteristics reflect past ecological and evolutionary dynamics. Here, we investigate whether it is possible to obtain realistically shaped modelled communities - i.e., with phylogenetic trees and species abundance distributions shaped similarly to typical empirical bird and mammal communities - from neutral community models. To test the effect of gene flow, we contrasted two spatially explicit individual-based neutral models: one with protracted speciation, delayed by gene flow, and one with point mutation speciation, unaffected by gene flow. The former produced more realistic communities (shape of phylogenetic tree and species-abundance distribution), consistent with gene flow being a key process in macro-evolutionary dynamics. Earlier models struggled to capture the empirically observed branching tempo in phylogenetic trees, as measured by the gamma statistic. We show that the low gamma values typical of empirical trees can be obtained in models with protracted speciation, in pre-equilibrium communities developing from an initially abundant and widespread species. This was even more so in communities sampled incompletely, particularly if the unknown species are the youngest. Overall, our results demonstrate that the characteristics of empirical communities that we have studied can, to a large extent, be explained through a purely neutral model under pre-equilibrium conditions. This article is protected by copyright. All rights reserved.

  11. Accelerated ketoprofen release from polymeric matrices: importance of the homogeneity/heterogeneity of excipient distribution.

    Gue, E; Willart, J F; Muschert, S; Danede, F; Delcourt, E; Descamps, M; Siepmann, J


    Polymeric matrices loaded with 10-50% ketoprofen were prepared by hot-melt extrusion or spray-drying. Eudragit E, PVP, PVPVA and HPMC were studied as matrix formers. Binary "drug-Eudragit E" as well as ternary "drug-Eudragit E-PVP", "drug-Eudragit E-PVPVA" and "drug-Eudragit E-HPMC" combinations were investigated and characterized by optical macro/microscopy, SEM, particle size measurements, mDSC, X-ray diffraction and in vitro drug release studies in 0.1 M HCl. In all cases ketoprofen release was much faster compared to a commercially available product and the dissolution of the drug powder (as received). Super-saturated solutions were obtained, which were stable during at least 2 h. Importantly, not only the composition of the systems, but also their inner structure potentially significantly affected the resulting ketoprofen release kinetics: For instance, spray-drying ternary ketoprofen:Eudragit E:HPMC combinations led to a more homogenous HPMC distribution within the systems than hot-melt extrusion, as revealed by mDSC and X-ray diffraction. This more homogenous HPMC distribution resulted in more pronounced hindrance for water and drug diffusion and, thus, slower drug release from spray-dried powder compared to hot-melt extrudates of identical composition. This "homogeneity/heterogeneity effect" even overcompensated the "system size effect": the surface exposed to the release medium was much larger in the case of the spray-dried powder. All formulations were stable during storage at ambient conditions in open vials.

  12. Evidence of arsenic release promoted by disinfection by-products within drinking-water distribution systems.

    Andra, Syam S; Makris, Konstantinos C; Botsaris, George; Charisiadis, Pantelis; Kalyvas, Harris; Costa, Costas N


    Changes in disinfectant type could trigger a cascade of reactions releasing pipe-anchored metals/metalloids into finished water. However, the effect of pre-formed disinfection by-products on the release of sorbed contaminants (arsenic-As in particular) from drinking water distribution system pipe scales remains unexplored. A bench-scale study using a factorial experimental design was performed to evaluate the independent and interaction effects of trihalomethanes (TTHM) and haloacetic acids (HAA) on arsenic (As) release from either scales-only or scale-biofilm conglomerates (SBC) both anchored on asbestos/cement pipe coupons. A model biofilm (Pseudomonas aeruginosa) was allowed to grow on select pipe coupons prior experimentation. Either TTHM or HAA individual dosing did not promote As release from either scales only or SBC, detecting water. In the case of scales-only coupons, the combination of the highest spike level of TTHM and HAA significantly (pdisinfected finished water in pipe networks remains to be investigated in the field.

  13. 分布式系统数据一致性处理的研究%Research on Consistency Processing of Data of Distributed System

    成汝震; 尚志恩; 刘宏忠; 张运凯


    Through structure and analyse of data object attribute, this paper discusses the scheme on consistency processing of distributed bot multimedia data of structured and common data. The scheme provides a new way for solving difficult problem of distributed data on consistency processing.

  14. The energy distribution structure and dynamic characteristics of energy release in electrostatic discharge process

    Liu, Qingming; Zhang, Yunming


    The detail structure of energy output and the dynamic characteristics of electric spark discharge process have been studied to calculate the energy of electric spark induced plasma under different discharge condition accurately. A series of electric spark discharge experiments were conducted with the capacitor stored energy in the range of 10J 100J and 1000J respectively. And the resistance of wire, switch and plasma between electrodes were evaluated by different methods. An optimized method for electric resistance evaluation of the full discharge circuit, three poles switch and electric spark induced plasma during the discharge process was put forward. The electric energy consumed by wire, electric switch and electric spark induced plasma between electrodes were obtained by Joules law. The structure of energy distribution and the dynamic process of energy release during the capacitor discharge process have been studied. Experiments results showed that, with the increase of capacitor released energy, the dura...

  15. Distribution and Persistence of Sterile Screwworms (Diptera: Calliphoridae) Released at the Panama-Colombia Border.

    Skoda, Steven R; Phillips, Pamela L; Sagel, Agustin; Chaudhury, Muhammad F


    The sterile insect technique is used by the Comisión Panamá - Estados Unidos para la Erradicación y Prevención del Gusano Barrenador del Ganado (COPEG) to maintain a barrier at the border of Panama and Colombia to prevent screwworms, Cochliomyia hominivorax (Coquerel), from South America reinfesting North America. Before studying the distribution and persistence of sterilized, mass-produced screwworms released in the barrier zone, the utility of applying fluorescent dust (∼1.0 mg/fly) to pupae and to newly emerged adults was evaluated to determine the potential effect on fly survival. The flight ability of flies collected from two adult emergence/collection systems (enclosed towers and open chambers) and treated with low (∼0.20 mg/fly) or high (∼1.0 mg/fly) amounts of fluorescent powder was compared. The distribution and persistence of sterile screwworms marked with fluorescent powder (∼0.20 mg/fly), after collection from the same two adult emergence/collection systems, was compared after their release in the barrier zone. The results demonstrated that: 1) fluorescent dust did not negatively affect sterile screwworm longevity or flight ability; 2) no differences were detected between sterile flies collected from the two emergence systems; and 3) sterile screwworms distributed evenly in the barrier zone and persisted for > 6 d. This information was useful in implementing the use of a new sterile fly emergence/collection system and deploying a new strain by COPEG for the barrier zone maintenance program; it will be valuable for evaluating alternative release strategies of sterile screwworms by the eradication and barrier maintenance program. Published by Oxford University Press on behalf of Entomological Society of America 2017. This work is written by US Government employees and is in the public domain in the US.

  16. MCNP(TM) Release 6.1.1 beta: Creating and Testing the Code Distribution

    Cox, Lawrence J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Casswell, Laura [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    This report documents the preparations for and testing of the production release of MCNP6™1.1 beta through RSICC at ORNL. It addresses tests on supported operating systems (Linux, MacOSX, Windows) with the supported compilers (Intel, Portland Group and gfortran). Verification and Validation test results are documented elsewhere. This report does not address in detail the overall packaging of the distribution. Specifically, it does not address the nuclear and atomic data collection, the other included software packages (MCNP5, MCNPX and MCNP6) and the collection of reference documents.

  17. Resurgence of Minimal Stimulation In Vitro Fertilization with A Protocol Consisting of Gonadotropin Releasing Hormone-Agonist Trigger and Vitrified-Thawed Embryo Transfer

    Zhang John


    Full Text Available Minimal stimulation in vitro fertilization (mini-IVF consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are reported here with a focus on the use of clomiphene citrate (CC, gonadotropin releasing hormone (GnRH ago- nist trigger for oocyte maturation, and freeze-all embryo strategy. Literature review and the author’s own center data suggest that minimal ovarian stimulation protocols with GnRH agonist trigger and freeze-all embryo strategy along with single embryo transfer produce a reasonable clinical pregnancy and live birth rates in both good and poor responders. Additionally, mini-IVF offers numerous advantages such as: i. Reduction in cost and stress with fewer office visits, needle sticks, and ultrasounds, and ii. Reduction in the incidence of ovarian hyperstimulation syndrome (OHSS. Mini-IVF is re-emerging as a solution for some of the problems associated with conventional IVF, such as OHSS, cost, and patient discomfort.

  18. Influence of drug distribution and solubility on release from geopolymer pellets--a finite element method study.

    Jämstorp, Erik; Strømme, Maria; Bredenberg, Susanne


    This study investigates the influence of drug solubility and distribution on its release from inert geopolymer pellets of three different sizes (1.5 × 1.5, 3 × 6, and 6 × 6 mm), having the same geopolymer composition and containing highly potent opioid fentanyl, sumatriptan, theophylline, or saccharin. Scanning electron microscopy, nitrogen sorption, drug solubility, permeation, and release experiments were performed, and estimates of the drug diffusion coefficients and solubilities in the geopolymer matrix were derived with the aid of finite element method (FEM). FEM was further employed to investigate the effect of a nonuniform drug distribution on the drug release profile. When inspecting the release profiles for each drug, it was observed that their solubilities in the geopolymer matrix imposed a much greater influence on the drug release rate than their diffusion coefficients. Concentrating the initial drug load in FEM into nonuniformly distributed drug regions inside the matrix created drug release profiles that more closely resembled experimental data than an FEM-simulated uniform drug distribution did. The presented FEM simulations and visualization of drug release from geopolymers under varying initial and dynamic conditions should open up for more systematic studies of additional factors that influence the drug release profile from porous delivery vehicles.

  19. Structure distribution and turbulence in self-consistently supernova-driven ISM of multiphase magnetized galactic discs

    Iffrig, Olivier; Hennebelle, Patrick


    and velocity fields and we conclude that they tend to be well aligned particularly at high magnetization and lower feedback. Finally, the dense structures present scaling relations that are reminiscent of the observational ones. The virial parameter is typically larger than 10 and shows a large spread of masses below 1000 M⊙. For masses larger than 104M⊙, its value tends to a few. Conclusions: Using a relatively simple scheme for the supernova feedback, which is self-consistently proportional to the SFR and spatially correlated to the star formation process, we reproduce a stratified galactic disc that presents reasonable scale height, SFR as well as a cloud distribution with characteristics close to the observed ones.

  20. Direct releases to the surface and associated complementary cumulative distribution functions in the 1996 performance assessments for the Waste Isolation Pilot Plant: Direct brine release



    The following topics related to the treatment of direct brine releases to the surface environment in the 1996 performance assessment for the Waste Isolation Pilot Plant (WIPP) are presented (1) mathematical description of models, (2) uncertainty and sensitivity analysis results arising from subjective (i.e., epistemic) uncertainty for individual releases, (3) construction of complementary cumulative distribution functions (CCDFs) arising from stochastic (i.e., aleatory) uncertainty, and (4) uncertainty and sensitivity analysis results for CCDFs. The presented analyses indicate that direct brine releases do not constitute a serious threat to the effectiveness of the WIPP as a disposal facility for transuranic waste. Even when the effects of uncertain analysis inputs are taken into account, the CCDFs for direct brine releases fall substantially to the left of the boundary line specified in the US Environmental Protection Agency's standard for the geologic disposal of radioactive waste (4O CFR 191.40 CFR 194).

  1. Towards a multiscale description of microvascular flow regulation: O2-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks

    Daniel eGoldman


    Full Text Available Integration of the numerous mechanisms that have been suggested to contribute to optimization of O2 supply to meet O2 need in skeletal muscle requires a systems biology approach which permits quantification of these physiological processes over a wide range of length scales. Here we describe two individual computational models based on in vivo and in vitro studies which, when incorporated into a single robust multiscale model, will provide information on the role of erythrocyte-released ATP in perfusion distribution in skeletal muscle under both physiological and pathophysiological conditions. Healthy human erythrocytes exposed to low O2 tension release ATP via a well characterized signaling pathway requiring activation of the G-protein, Gi, and adenylyl cyclase leading to increases in cAMP. This cAMP then activates PKA and subsequently CFTR culminating in ATP release via pannexin 1. A critical control point in this pathway is the level of cAMP which is regulated by pathway-specific phosphodiesterases. Using time constants (~100ms that are consistent with measured erythrocyte ATP release, we have constructed a dynamic model of this pathway. The model predicts levels of ATP release consistent with measurements obtained over a wide range of hemoglobin O2 saturations (sO2. The model further predicts how insulin, at concentrations found in prediabetes, enhances the activity of PDE3 and reduces intracellular cAMP levels leading to decreased low O2-induced ATP release from erythrocytes. The second model, which couples O2 and ATP transport in capillary networks, shows how intravascular ATP and the resulting conducted vasodilation are affected by local sO2, convection and ATP degradation. This model also predicts network-level effects of decreased ATP release resulting from elevated insulin levels. Taken together, these models lay the groundwork for investigating the systems biology of the regulation of microvascular perfusion distribution by

  2. A Bayesian Mean-Value Approach with a Self-Consistently Determined Prior Distribution for the Ranking of College Football Teams

    Ashburn, J R; Ashburn, James R.; Colvert, Paul M.


    We introduce a Bayesian mean-value approach for ranking all college football teams using only win-loss data. This approach is unique in that the prior distribution necessary to handle undefeated and winless teams is calculated self-consistently. Furthermore, we will show statistics supporting the validity of the prior distribution. Finally, a brief comparison with other football rankings will be presented.

  3. Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor.

    de Groef, Bert; Grommen, Sylvia V H; Mertens, Inge; Schoofs, Liliane; Kühn, Eduard R; Darras, Veerle M


    We report the cloning of the complete coding sequence of the putative chicken type 2 corticotropin-releasing hormone receptor (CRH-R2) by rapid amplification of cDNA ends (RACE). The chicken CRH-R2 is a 412-amino acid 7-transmembrane G protein-coupled receptor, showing 87% identity to the Xenopus laevis and Oncorhynchus keta CRH-R2s, and 78-80% to mammalian CRH-R2s. The distribution of CRH-R2 mRNA was studied by RT-PCR analysis and compared to CRH-R1 distribution. Both CRH-R1 and CRH-R2 mRNA are expressed in the main chicken brain parts. In peripheral organs, CRH-R1 mRNA shows a more restricted distribution, whereas CRH-R2 mRNA is expressed in every tissue investigated, indicating that a number of actions of CRH and/or CRH-like peptides remain to be discovered in the chicken as well as in other vertebrates.

  4. Patterns in the uptake, release, distribution, and the transfer of petroleum hydrocarbons in marine organisms

    Ba-Akdah, M.A.S.


    The uptake and depuration patterns of petroleum hydrocarbons by marine invertebrates was studied using two deposit feeders, Scrobicularia plana (Bivalvia) and Arenicola marina (Polychaeta), and the suspension feeder Mytilus edulis (Bivalvia) using initial concentration of 500 ppm total oil in both sediments and seawater. It was shown that uptake and release of petroleum hydrocarbons was much higher and rapid from seawater than from sediment. The uptake, distribution, release, and the transfer of two PAHs, [9-{sup 14}C]-phenanthrene and [G-{sup 3}H]-benzo(a)pyrene were investigated separately through 3 trophic levels (mussels-amphipods-fish). It appeared that the mussel are capable of accumulating significant levels of these radiolabelled compounds from seawater into their tissues. The highest levels of radioactivity was localized in the visceral mass, followed by the mantle and gills, whereas the lowest content was found in the muscle. The elimination of the radioactivity of {sup 14}C-PHN was more rapid than the {sup 3}H-B(a)P. Gammarus locusta (the second trophic level in this study) freely fed on mussels contaminated with {sup 14}C-PHN or {sup 3}H-B(a)P showed a rapid uptake reaching its maximum in 2 days. The cumulative percentage retaintion ranged between 30-40% of the dose. (Author)

  5. Tracing organic matter composition and distribution and its role on arsenic release in shallow Cambodian groundwaters

    Lawson, Michael; Polya, David A.; Boyce, Adrian J.; Bryant, Charlotte; Ballentine, Christopher J.


    Biogeochemical processes that utilize dissolved organic carbon are widely thought to be responsible for the liberation of arsenic from sediments to shallow groundwater in south and southeast Asia. The accumulation of this known carcinogen to hazardously high concentrations has occurred in the primary source of drinking water in large parts of densely populated countries in this region. Both surface and sedimentary sources of organic matter have been suggested to contribute dissolved organic carbon in these aquifers. However, identification of the source of organic carbon responsible for driving arsenic release remains enigmatic and even controversial. Here, we provide the most extensive interrogation to date of the isotopic signature of ground and surface waters at a known arsenic hotspot in Cambodia. We present tritium and radiocarbon data that demonstrates that recharge through ponds and/or clay windows can transport young, surface derived organic matter into groundwater to depths of 44 m under natural flow conditions. Young organic matter dominates the dissolved organic carbon pool in groundwater that is in close proximity to these surface water sources and we suggest this is likely a regional relationship. In locations distal to surface water contact, dissolved organic carbon represents a mixture of both young surface and older sedimentary derived organic matter. Ground-surface water interaction therefore strongly influences the average dissolved organic carbon age and how this is distributed spatially across the field site. Arsenic mobilization rates appear to be controlled by the age of dissolved organic matter present in these groundwaters. Arsenic concentrations in shallow groundwaters (20 m) groundwaters. We suggest that, while the rate of arsenic release is greatest in shallow aquifer sediments, arsenic release also occurs in deeper aquifer sediments and as such remains an important process in controlling the spatial distribution of arsenic in the

  6. Maternal-fetal distribution of mercury ( sup 203 Hg) released from dental amalgam fillings

    Vimy, M.J.; Takahashi, Y.; Lorscheider, F.L. (Univ. of Calgary, Alberta (Canada))


    In humans, the continuous release of Hg vapor from dental amalgam tooth restorations is markedly increased for prolonged periods after chewing. The present study establishes a time-course distribution for amalgam Hg in body tissues of adult and fetal sheep. Under general anesthesia, five pregnant ewes had twelve occlusal amalgam fillings containing radioactive 203Hg placed in teeth at 112 days gestation. Blood, amniotic fluid, feces, and urine specimens were collected at 1- to 3-day intervals for 16 days. From days 16-140 after amalgam placement (16-41 days for fetal lambs), tissue specimens were analyzed for radioactivity, and total Hg concentrations were calculated. Results demonstrate that Hg from dental amalgam will appear in maternal and fetal blood and amniotic fluid within 2 days after placement of amalgam tooth restorations. Excretion of some of this Hg will also commence within 2 days. All tissues examined displayed Hg accumulation. Highest concentrations of Hg from amalgam in the adult occurred in kidney and liver, whereas in the fetus the highest amalgam Hg concentrations appeared in liver and pituitary gland. The placenta progressively concentrated Hg as gestation advanced to term, and milk concentration of amalgam Hg postpartum provides a potential source of Hg exposure to the newborn. It is concluded that accumulation of amalgam Hg progresses in maternal and fetal tissues to a steady state with advancing gestation and is maintained. Dental amalgam usage as a tooth restorative material in pregnant women and children should be reconsidered.

  7. Flexibility on storage-release based distributed hydrologic modeling with object-oriented approach

    Kang, Kwangmin; Merwade, Venkatesh; Chun, Jong Ahn; Timlin, Dennis


    With the availability of advanced hydrologic data in public domain such as remote sensed and climate change scenario data, there is a need for a modeling framework that is capable of using these data to simulate and extend hydrologic processes with multidisciplinary approaches for sustainable water resources management. To address this need, a storage-release based distributed hydrologic model (STORE DHM) is developed based on an object-oriented approach. The model is tested for demonstrating model flexibility and extensibility to know how to well integrate object-oriented approach to further hydrologic research issues, e.g., reconstructing missing precipitation in this study, without changing its main frame. Moreover, the STORE DHM is applied to simulate hydrological processes with multiple classes in the Nanticoke watershed. This study also describes a conceptual and structural framework of object-oriented inheritance and aggregation characteristics under the STORE DHM. In addition, NearestMP (missing value estimation based on nearest neighborhood regression) and KernelMP (missing value estimation based on Kernel Function) are proposed for evaluating STORE DHM flexibility. And then, STORE DHM runoff hydrographs compared with NearestMP and KernelMP runoff hydrographs. Overall results from these comparisons show promising hydrograph outputs generated by the proposed two classes. Consequently, this study suggests that STORE DHM with an object-oriented approach will be a comprehensive water resources modeling tools by adding additional classes for toward developing through its flexibility and extensibility.

  8. Self-consistent covariant description of twist-3 distribution amplitude of a pseudoscalar meson in the light-front quark model

    Choi, Ho-Meoyng


    We discuss the light-front zero-mode issue in the light-front quark model prediction of the twist-3 distribution amplitude of a pseudoscalar meson from the perspective of the vacuum fluctuation consistent with the chiral symmetry of QCD.

  9. In vitro release of 1,3-bis (2-chloroethyl)-1-nitrosourea sustained-release microspheres and the distribution in rat brain tissues

    Xia Li; Liping Guo; Qin Li


    BACKGROUND: The implantation of released chemotherapeutic drugs, which takes biodegradable polymer as vector, into the tumor site can get high concentration and release the drug for a long time, it can directly act on the tumor cells, and reduce the general toxicity.OBJECTIVE: To explore the in vitro and in vivo course of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) sustained-release from BCNU-loaded polylactide (PLA) microspheres (MS) and location in rat brain tissue.DESIGN: A repetitive measurement.SETTING: Central Pharmacy, General Hospital of Chinese People's Armed Police Forces.MATERIALS: Thirty male SD rats were used. PLA (Mr5000, batch number: KSL8377) was produced by Wako Pure Chemical Inc.,Ltd. (Japan); BCNU (batch number: 021121) by Tianjin Jinyao Amino Acid Co., Ltd.;BCNU-PLA-MS was prepared by the method of solvent evaporation and pressed into tablets (10 mg/tablet).High-performance liquid chromatography (HPLC) Agilent 1100 (USA); LS9800 liquid-scintillation radiometric apparatus (Beckman). Chromatographic conditions: Elite Hypersil ODS2 C18 chromatographic column (5 μm,4.6 mm ×150 mm); Mobile phase: methanol: water (50:50), flow rate was 1.0 mL per minute, wave length of ultraviolet detection was 237 nm, and the inlet amount of samples was 10 μL.METHODS: The experiments were carried out in the experimental animal center of the General Hospital of Chinese Armed Police from May 2004 to July 2005. ① In vitro BCNU-PLA-MS release test: BCNU-PLA-MS was prepared by the method of solvent evaporation, then placed in 0.1 mol/L phosphate buffered solution (PBS, pH 7.4, 37 ℃), part of MS were taken out at 1, 2, 3, 7, 10 and 15 days respectively, and the rest amount of BCNU in MS was determined by HPLC, then the curve of BCNU-PLA-MS release was drawn. ②In vivo BCNU-PLA-MS release and distribution test: The rats were anesthetized, then BCNU-PLA-MS were implanted to the site 1 mm inferior to the cortex of frontal lobe. Five rats were killed postoperatively

  10. Formation and Release Behavior of Iron Corrosion Products under the Influence of Bacterial Communities in a Simulated Water Distribution System

    Understanding the effects of biofilm on the iron corrosion, iron release and associated corrosion by-products is critical for maintaining the water quality and the integrity of drinking water distribution system (DWDS). In this work, iron corrosion experiments under sterilized a...

  11. In vitro release control of ketoprofen from pH-sensitive gels consisting of poly(acryloyl- L-proline methyl ester) and saturated fatty acid sodium salts

    Negishi, M.; Hiroki, A.; Miyajima, M.; Yoshida, M.; Asano, M.; Katakai, R.


    The effect of saturated fatty acid sodium salts (C n), sodium laurate (C 12), sodium myristate (C 14), sodium palmitate (C 16), and sodium stearate (C 18), on the swelling of poly(acryloyl- L-proline methyl ester) (A-ProOMe) gel was investigated in different pH solutions. The C n-loaded gels collapsed in a buffer solution with pH 3.0, while they expanded in a buffer solution with pH 6.5. This effect was strongly influenced by the number of methylene units in C n, as the threshold for causing this sensitivity existed between C 12 and C 14. On the other hand, a pulsatile release of ketoprofen occurred when the gel was cycled in buffer solutions between pH 3.0 and pH 6.5. This behavior may be attributable to the surface-regulated mechanism.

  12. Distribution of dipyridamole in blood components among post-stroke patients treated with extended release formulation.

    Serebruany, Victor; Sabaeva, Elena; Booze, Christopher; Atar, Oliver D; Eisert, Christian; Hanley, Dan


    Extended release dipyridamole (ERD) is widely used in patients after ischaemic stroke; however, the ability of this antithrombotic agent to be stored in different blood cells has never been explored in post-stroke patients. We hypothesised that since ERD is known to be highly lipophilic, the drug may be present not only in plasma, but also accumulated in platelets, leukocytes, and erythrocytes. Fifteen patients after documented ischaemic stroke were treated with Aggrenox (ERD and low-dose aspirin combination) BID for 30 days, and 12 of them completed the study. ERD concentrations in blood cells and platelet-poor plasma were measured by spectrofluorimetry at Baseline, Day 14, and Day 30 after the initiation of therapy. The background level of spectrofluorometry readings differs slightly among the blood components (132-211 ng/ml) due to the differences in the preparation of samples and cell isolation techniques. As expected, two weeks of ERD therapy produced steady-state plasma concentration of dipyridamole already at Day 14 (1,680 +/- 542 ng/ ml), followed by a slight not significant decrease at one month (1,619 +/- 408 ng/ml). Two weeks of therapy was sufficient to achieve a consistent dipyridamole accumulation in erythrocytes (361 +/- 43 ng/ml), but not in platelets (244 +/- 78 ng/ml), or leukocytes (275 +/- 49 ng/ml). In fact, white blood cells continued dipyridamole intake beyond 14 days period, and this increase (398 +/- 66 ng/ml) was significant (p = 0.02) at 30 days. Treatment with ERD in post-stroke patients resulted not only in achievement of therapeutic plasma dipyridamole concentrations, but also deposition of the drug in erythrocytes and leukocytes, but not in platelets. If confirmed, these data will affect our better understanding of dipyridamole pleiotropy, and may explain long-term benefit of ERD formulation.

  13. [Effect of the change in sulphate and dissolved oxygen mass concentration on metal release in old cast iron distribution pipes].

    Wu, Yong-li; Shi, Bao-you; Sun, Hui-fang; Zhang, Zhi-huan; Gu, Jun-nong; Wang, Dong-sheng


    To understand the processes of corrosion by-product release and the consequent "red water" problems caused by the variation of water chemical composition in drinking water distribution system, the effect of sulphate and dissolved oxygen (DO) concentration on total iron release in corroded old iron pipe sections historically transporting groundwater was investigated in laboratory using small-scale pipe section reactors. The release behaviors of some low-level metals, such as Mn, As, Cr, Cu, Zn and Ni, in the process of iron release were also monitored. The results showed that the total iron and Mn release increased significantly with the increase of sulphate concentration, and apparent red water occurred when sulphate concentration was above 400 mg x L(-1). With the increase of sulfate concentration, the effluent concentrations of As, Cr, Cu, Zn and Ni also increased obviously, however, the effluent concentrations of these metals were lower than the influent concentrations under most circumstances, which indicated that adsorption of these metals by pipe corrosion scales occurred. Increasing DO within a certain range could significantly inhibit the iron release.

  14. Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

    Alex Loebel


    Full Text Available Inter-pyramidal synaptic connections are characterized by a wide range of EPSP amplitudes. Although repeatedly observed at different brain regions and across layers, little is known about the synaptic characteristics that contribute to this wide range. In particular, the range could potentially be accounted for by differences in all three parameters of the quantal model of synaptic transmission, i.e. the number of release sites, release probability and quantal size. Here, we present a rigorous statistical analysis of the transmission properties of excitatory synaptic connections between layer-5 pyramidal neurons of the somatosensory cortex. Our central finding is that the EPSP amplitude is strongly correlated with the number of estimated release sites, but not with the release probability or quantal size. In addition, we found that the number of release sites can be more than an order of magnitude higher than the typical number of synaptic contacts for this type of connection. Our findings indicate that transmission at stronger synaptic connections is mediated by multiquantal release from their synaptic contacts. We propose that modulating the number of release sites could be an important mechanism in regulating neocortical synaptic transmission.

  15. Releases, distribution and abundance of Gratiana boliviana (Coleoptera:Chrysomelidae), a biological control agent of tropical soda apple (Solanum viarum, Solanaceae), in Florida

    A biological control program against tropical soda apple (TSA) (Solanum viarum Dunal (Solanaceae)) released 176,643 Gratiana boliviana Spaeth (Coleoptera: Chrysomelidae) in Florida from 2003 to 2008. The spatial distribution of releases was clustered with more beetles released in south/central Flor...

  16. Accelerated ketoprofen release from spray-dried polymeric particles: importance of phase transitions and excipient distribution.

    Gue, Emilie; Muschert, Susanne; Willart, Jean-Francois; Danede, Florence; Delcourt-Debruyne, Elisabeth; Descamps, Marc; Siepmann, Juergen


    HPMC-, PVPVA- and PVP-based microparticles loaded with 30% ketoprofen were prepared by spray drying suspensions or solutions in various water:ethanol blends. The inlet temperature, drying gas and feed flow rates were varied. The resulting differences in the ketoprofen release rates in 0.1 M HCl could be explained based on X-ray diffraction, mDSC, SEM and particle size analysis. Importantly, long term stable drug release could be provided, being much faster than: (i) drug release from a commercial reference product, (ii) the respective physical drug:polymer mixtures, as well as (iii) the dissolution of ketoprofen powder as received. In addition, highly supersaturated release media were obtained, which did not show any sign for re-crystallization during the observation period. Surprisingly, spraying suspensions resulted in larger microparticles exhibiting faster drug release compared to spraying solutions, which resulted in smaller particles exhibiting slower drug release. These effects could be explained based on the physico-chemical characteristics of the systems.


    Paulo César Teixeira


    Full Text Available This research had as objective to verify the influence in growth, nutrition and dry matter partition in oil palm seedling by type and dosages of slow release fertilizers (SRF and percentage of tray occupation by plastic containers during pre-nursery. The experiment consisted of 16 treatments, in factorial scheme: two types of SRF (Osmocote® e Basacote mini, two dosages (0 and 3 kg/m3 and four schemes for the container distribution used to attain 100%, 66%, 50% and 25% of tray occupation. An additional treatment composed of 15 x 15 cm plastic bags filled with soil was added. Pre-germinated seeds of oil palm were put in plastic containers of 120 cm3 containing substratum and in plastic bags containing soil. After three months, the seedlings were transplanted to 40 x 40 cm plastic bags containing soil. At this time, height, diameter, dry matter and concentration of N, P, K, Ca and Mg were evaluated. After 10 months, seedlings were evaluated for height and diameter and after 16 months, seedlings had the height, diameter and dry matter weight evaluated. Addition of SRF was fundamental for seedlings development. Different percentages of tray occupation by containers during pre-nursery did not influence height and diameter of oil palm seedlings at 10 and 16 months old. The evaluation after 10 months showed that plants fertilized with Osmocote® were higher than those fertilized with Basacote mini. The evaluations after 16 months showed that plants fertilized during the pre-nursery had higher height, diameter and leaflets, leaf, aboveground and total dry matter than plants not fertilized.

  18. Influences of increased daily repeated upstream releases and varying meteorological conditions on temperature distributions in a river-reservoir system

    Chen, G.; Fang, X.


    Temperature distribution in a river-reservoir system was simulated using a calibrated three-dimensional Environmental Fluid Dynamics Code model under various hypothetical weather conditions and daily repeated large releases (DRLRs) from the upstream boundary. Both DRLRs and weather conditions affect and control the formation and spread of density currents and then affect the bottom-layer temperatures. The DRLRs with longer durations (e.g., 6 or 8 hours) can relatively quickly push cooler release water to the Gorgas upstream monitoring station (GOUS) and the river intake. With the air temperature drops in the first 6 days, simulated bottom temperatures at GOUS for 6- and 8-hr DRLRs are lower than one under 4-hr DRLR, but relatively larger bottom-layer temperature drops only primarily occur during the air-temperature drop and rise period. The release with larger flow rate can also maintain the cooler water temperature downstream. Releasing the same amounts of water, with different release durations and flow rates, has a very similar effect on the downstream water temperatures.

  19. The Human Carbon Budget: An Estimate of the Spatial Distribution of Metabolic Carbon Consumption and Release in the United States

    West, Tristram O. [ORNL; Singh, Nagendra [ORNL; Marland, Gregg [ORNL; Bhaduri, Budhendra L [ORNL


    Carbon dioxide is taken up by agricultural crops and released soon after during the consumption of agricultural commodities. The global net impact of this process on carbon flux to the atmosphere is negligible, but impact on the spatial distribution of carbon dioxide uptake and release across regions and continents is significant. To estimate the consumption and release of carbon by humans over the landscape, we developed a carbon budget for humans in the United States. The budget was derived from food commodity intake data for the US and from algorithms representing the metabolic processing of carbon by humans. Data on consumption, respiration, and waste of carbon by humans were distributed over the US using geospatial population data with a resolution of approximately 450 x 450 m. The average adult in the US contains about 21 kg C and consumes about 67 kg C yr-1 which is balanced by the annual release of about 59 kg C as expired CO2, 7 kg C as feces and urine, and less than 1 kg C as flatus, sweat, and aromatic compounds. In 2000, an estimated 17.2 Tg C were consumed by the US population and 15.2 Tg C were expired to the atmosphere as CO2. Historically, carbon stock in the US human population has increased between 1790-2006 from 0.06 Tg to 5.37 Tg. Displacement and release of total harvested carbon per capita in the US is nearly 12% of per capita fossil fuel emissions. Humans are using, storing, and transporting carbon about the Earth s surface. Inclusion of these carbon dynamics in regional carbon budgets can improve our understanding of carbon sources and sinks.

  20. Interface Consistency

    Staunstrup, Jørgen


    This paper proposes that Interface Consistency is an important issue for the development of modular designs. Byproviding a precise specification of component interfaces it becomes possible to check that separately developedcomponents use a common interface in a coherent matter thus avoiding a very...... significant source of design errors. Awide range of interface specifications are possible, the simplest form is a syntactical check of parameter types.However, today it is possible to do more sophisticated forms involving semantic checks....

  1. University releases 'Hokie Mobile' application for distribution through iTunes store

    Jackson, John


    Virginia Tech has released the university's first application for use on the iPhone and iPod Touch through the Apple iTunes store. The free app is called Hokie Mobile and provides users with campus news, events, maps, and a directory search.

  2. Deformation and stress distribution of the human foot after plantar ligaments release: a cadaveric study and finite element analysis.

    Liang, Jun; Yang, Yunfeng; Yu, Guangrong; Niu, Wenxin; Wang, Yubin


    The majority of foot deformities are related to arch collapse or instability, especially the longitudinal arch. Although the relationship between the plantar fascia and arch height has been previously investigated, the stress distribution remains unclear. The aim of this study was to explore the role of the plantar ligaments in foot arch biomechanics. We constructed a geometrical detailed three-dimensional (3-D) finite element (FE) model of the human foot and ankle from computer tomography images. The model comprised the majority of joints in the foot as well as bone segments, major ligaments, and plantar soft tissue. Release of the plantar fascia and other ligaments was simulated to evaluate the corresponding biomechanical effects on load distribution of the bony and ligamentous structures. These intrinsic ligaments of the foot arch were sectioned to simulate different pathologic situations of injury to the plantar ligaments, and to explore bone segment displacement and stress distribution. The validity of the 3-D FE model was verified by comparing results with experimentally measured data via the displacement and von Mise stress of each bone segment. Plantar fascia release decreased arch height, but did not cause total collapse of the foot arch. The longitudinal foot arch was lost when all the four major plantar ligaments were sectioned simultaneously. Plantar fascia release was compromised by increased strain applied to the plantar ligaments and intensified stress in the midfoot and metatarsal bones. Load redistribution among the centralized metatarsal bones and focal stress relief at the calcaneal insertion were predicted. The 3-D FE model indicated that plantar fascia release may provide relief of focal stress and associated heel pain. However, these operative procedures may pose a risk to arch stability and clinically may produce dorsolateral midfoot pain. The initial strategy for treating plantar fasciitis should be non-operative.

  3. Solid consistency

    Bordin, Lorenzo; Creminelli, Paolo; Mirbabayi, Mehrdad; Noreña, Jorge


    We argue that isotropic scalar fluctuations in solid inflation are adiabatic in the super-horizon limit. During the solid phase this adiabatic mode has peculiar features: constant energy-density slices and comoving slices do not coincide, and their curvatures, parameterized respectively by ζ and Script R, both evolve in time. The existence of this adiabatic mode implies that Maldacena's squeezed limit consistency relation holds after angular average over the long mode. The correlation functions of a long-wavelength spherical scalar mode with several short scalar or tensor modes is fixed by the scaling behavior of the correlators of short modes, independently of the solid inflation action or dynamics of reheating.

  4. Formation and release behavior of iron corrosion products under the influence of bacterial communities in a simulated water distribution system.

    Sun, Huifang; Shi, Baoyou; Lytle, Darren A; Bai, Yaohui; Wang, Dongsheng


    To understand the formation and release behavior of iron corrosion products in a drinking water distribution system, annular reactors (ARs) were used to investigate the development processes of corrosion products and biofilm community as well as the concomitant iron release behavior. Results showed that the formation and transformation of corrosion products and bacterial community are closely related to each other. The presence of sulfate-reducing bacteria (SRB, e.g. Desulfovibrio and Desulfotomaculum), sulfur-oxidizing bacteria (SOB, e.g. Sulfuricella), and iron-oxidizing bacteria (IOB, e.g. Acidovorax, Gallionella, Leptothrix, and Sphaerotilus) in biofilms could speed up iron corrosion; however, iron-reducing bacteria (IRB, e.g. Bacillus, Clostridium, and Pseudomonas) could inhibit iron corrosion and iron release. Corrosion scales on iron coupons could develop into a two-layered structure (top layer and inner layer) with time. The relatively stable constituents such as goethite (α-FeOOH) and magnetite (Fe3O4) mainly existed in the top layers, while green rust (Fe6(OH)12CO3) mainly existed in the inner layers. The IOB (especially Acidovorax) contributed to the formation of α-FeOOH, while IRB and the anaerobic conditions could facilitate the formation of Fe3O4. Compared with the AR test without biofilms, the iron corrosion rate with biofilms was relatively higher (p iron release with biofilms was obviously lower both at the initial stage and after 3 months. Biofilm and corrosion scale samples formed under different water supply conditions in an actual drinking water distribution system verified the relationships between the bacterial community and corrosion products.

  5. Both size-frequency distribution and sub-populations of the main-belt asteroid population are consistent with YORP-induced rotational fission

    Jacobson, S.; Scheeres, D.; Rossi, A.; Marzari, F.; Davis, D.


    From the results of a comprehensive asteroid-population-evolution model, we conclude that the YORP-induced rotational-fission hypothesis has strong repercussions for the small size end of the main-belt asteroid size-frequency distribution and is consistent with observed asteroid-population statistics and with the observed sub-populations of binary asteroids, asteroid pairs and contact binaries. The foundation of this model is the asteroid-rotation model of Marzari et al. (2011) and Rossi et al. (2009), which incorporates both the YORP effect and collisional evolution. This work adds to that model the rotational fission hypothesis (i.e. when the rotation rate exceeds a critical value, erosion and binary formation occur; Scheeres 2007) and binary-asteroid evolution (Jacobson & Scheeres, 2011). The YORP-effect timescale for large asteroids with diameters D > ˜ 6 km is longer than the collision timescale in the main belt, thus the frequency of large asteroids is determined by a collisional equilibrium (e.g. Bottke 2005), but for small asteroids with diameters D Morbidelli 2009). The binary-asteroid evolution model is highly constrained by the modeling done in Jacobson & Scheeres, and therefore the asteroid-population evolution model has only two significant free parameters: the ratio of low-to-high-mass-ratio binaries formed after rotational fission events and the mean strength of the binary YORP (BYORP) effect. Using this model, we successfully reproduce the observed small-asteroid sub-populations, which orthogonally constrain the two free parameters. We find the outcome of rotational fission most likely produces an initial mass-ratio fraction that is four to eight times as likely to produce high-mass-ratio systems as low-mass-ratio systems, which is consistent with rotational fission creating binary systems in a flat distribution with respect to mass ratio. We also find that the mean of the log-normal BYORP coefficient distribution B ≈ 10^{-2}.

  6. Distribution of sulfur aerosol precursors in the SPCZ released by continuous volcanic degassing at Ambrym, Vanuatu

    Lefèvre, Jérôme; Menkes, Christophe; Bani, Philipson; Marchesiello, Patrick; Curci, Gabriele; Grell, Georg A.; Frouin, Robert


    The Melanesian Volcanic Arc (MVA) emits about 12 kT d- 1 of sulfur dioxide (SO2) to the atmosphere from continuous passive (non-explosive) volcanic degassing, which contributes 20% of the global SO2 emission from volcanoes. Here we assess, from up-to-date and long-term observations, the SO2 emission of the Ambrym volcano, one of the dominant volcanoes in the MVA, and we investigate its role as sulfate precursor on the regional distribution of aerosols, using both satellite observations and model results at 1° × 1° spatial resolution from WRF-Chem/GOCART. Without considering aerosol forcing on clouds, our model parameterizations for convection, vertical mixing and cloud properties provide a reliable chemical weather representation, making possible a cross-examination of model solution and observations. This preliminary work enables the identification of biases and limitations affecting both the model (missing sources) and satellite sensors and algorithms (for aerosol detection and classification) and leads to the implementation of improved transport and aerosol processes in the modeling system. On the one hand, the model confirms a 50% underestimation of SO2 emissions due to satellite swath sampling of the Ozone Monitoring Instrument (OMI), consistent with field studies. The OMI irregular sampling also produces a level of noise that impairs its monitoring capacity during short-term volcanic events. On the other hand, the model reveals a large sensitivity on aerosol composition and Aerosol Optical Depth (AOD) due to choices of both the source function in WRF-Chem and size parameters for sea-salt in FlexAOD, the post-processor used to compute offline the simulated AOD. We then proceed to diagnosing the role of SO2 volcanic emission in the regional aerosol composition. The model shows that both dynamics and cloud properties associated with the South Pacific Convergence Zone (SPCZ) have a large influence on the oxidation of SO2 and on the transport pathways of

  7. 基于一致性Hash算法的分布式缓存数据冗余%Redundancy of Distributed Cache Data Based on Consistent Hash Algorithm



    为了优化大型分布式网站中的数据缓存机制 ,提出基于一致性 Hash算法的缓存数据冗余机制.分析不同散列函数性能 ,使数据能均匀分布在Hash环上不同节点 ,使用二分法在主从 Hash环上分别进行存取缓存数据.本地测试及结果分析表明 ,该冗余机制明显优于直接读库和单机缓存 ,在分布式系统中能有效降低冗余操作带来的性能损耗 ,提高了网站的健壮性和稳定性 ,为高并发、分布式缓存系统设计提供了一个新的思路.%In order to optimize the data caching mechanism in large distributed sites ,this paper propose the redundancy of cache data based on Consistent Hash Algorithm ,analyze the performance of different hash functions to distribute the data on the nodes of hash ring evenly .Set and get data in Master-Slave hash rings respectively in use of dichotomy .Through local testing and analysis ,we found that the redundancy mechanism is significantly better than reading the database direct-ly or local cache ,the performance loss of backup operations can be effectively reduced in distributed system .Therefore this mechanism can improve the robustness and stability of the site ,and provide new ideas to the design of high concurren-cy ,distributed cache system .

  8. Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy

    Christophersen, Philip C.; Birch, Ditlev; Saarinen, Jukka


    The aim of this study was to gain new insights into protein distribution in solid lipid microparticles (SLMs) and subsequent release mechanisms using a novel label-free chemical imaging method, coherent anti-Stokes Raman scattering (CARS) microscopy. Lysozyme-loaded SLMs were prepared using...... different lipids with lysozyme incorporated either as an aqueous solution or as a solid powder. Lysozyme distribution in SLMs was investigated using CARS microscopy with supportive structural analysis using electron microscopy. The release of lysozyme from SLMs was investigated in a medium simulating......-destructive method for elucidating the distribution of lysozyme in SLMs. The interpretation of protein distribution and release during lipolysis enabled elucidation of protein release mechanisms. In future, CARS microscopy analysis could facilitate development of a wide range of protein-lipid matrices with tailor...

  9. Release the BEESTS: Bayesian Estimation of Ex-Gaussian STop-Signal Reaction Time Distributions

    Dora eMatzke


    Full Text Available The stop-signal paradigm is frequently used to study response inhibition. Inthis paradigm, participants perform a two-choice response time task wherethe primary task is occasionally interrupted by a stop-signal that promptsparticipants to withhold their response. The primary goal is to estimatethe latency of the unobservable stop response (stop signal reaction timeor SSRT. Recently, Matzke, Dolan, Logan, Brown, and Wagenmakers (inpress have developed a Bayesian parametric approach that allows for theestimation of the entire distribution of SSRTs. The Bayesian parametricapproach assumes that SSRTs are ex-Gaussian distributed and uses Markovchain Monte Carlo sampling to estimate the parameters of the SSRT distri-bution. Here we present an efficient and user-friendly software implementa-tion of the Bayesian parametric approach —BEESTS— that can be appliedto individual as well as hierarchical stop-signal data. BEESTS comes withan easy-to-use graphical user interface and provides users with summarystatistics of the posterior distribution of the parameters as well various diag-nostic tools to assess the quality of the parameter estimates. The softwareis open source and runs on Windows and OS X operating systems. In sum,BEESTS allows experimental and clinical psychologists to estimate entiredistributions of SSRTs and hence facilitates the more rigorous analysis ofstop-signal data.

  10. Five gonadotrophin-releasing hormone receptors in a teleost fish: isolation, tissue distribution and phylogenetic relationships.

    Moncaut, Natalia; Somoza, Gustavo; Power, Deborah M; Canário, Adelino V M


    Gonadotrophin-releasing hormone (GnRH) is the main neurohormone controlling gonadotrophin release in all vertebrates, and in teleost fish also of growth hormone and possibly of other adenohypophyseal hormones. Over 20 GnRHs have been identified in vertebrates and protochoordates and shown to bind cognate G-protein couple receptors (GnRHR). We have searched the puffer fish, Fugu rubripes, genome sequencing database, identified five GnRHR genes and proceeded to isolate the corresponding complementary DNAs in European sea bass, Dicentrachus labrax. Phylogenetic analysis clusters the European sea bass, puffer fish and all other vertebrate receptors into two main lineages corresponding to the mammalian type I and II receptors. The fish receptors could be subdivided in two GnRHR1 (A and B) and three GnRHR2 (A, B and C) subtypes. Amino acid sequence identity within receptor subtypes varies between 70 and 90% but only 50-55% among the two main lineages in fish. All European sea bass receptor mRNAs are expressed in the anterior and mid brain, and all but one are expressed in the pituitary gland. There is differential expression of the receptors in peripheral tissues related to reproduction (gonads), chemical senses (eye and olfactory epithelium) and osmoregulation (kidney and gill). This is the first report showing five GnRH receptors in a vertebrate species and the gene expression patterns support the concept that GnRH and GnRHRs play highly diverse functional roles in the regulation of cellular functions, besides the "classical" role of pituitary function regulation.

  11. Reduction of spatial distribution of risk factors for transportation of contaminants released by coal mining activities.

    Karan, Shivesh Kishore; Samadder, Sukha Ranjan


    It is reported that water-energy nexus composes two of the biggest development and human health challenges. In the present study we presented a Risk Potential Index (RPI) model which encapsulates Source, Vector (Transport), and Target risks for forecasting surface water contamination. The main aim of the model is to identify critical surface water risk zones for an open cast mining environment, taking Jharia Coalfield, India as the study area. The model also helps in feasible sampling design. Based on spatial analysis various risk zones were successfully delineated. Monthly RPI distribution revealed that the risk of surface water contamination was highest during the monsoon months. Surface water samples were analysed to validate the model. A GIS based alternative management option was proposed to reduce surface water contamination risk and observed 96% and 86% decrease in the spatial distribution of very high risk areas for the months June and July respectively.

  12. Reynolds number scaling to predict droplet size distribution in dispersed and undispersed subsurface oil releases.

    Li, Pu; Weng, Linlu; Niu, Haibo; Robinson, Brian; King, Thomas; Conmy, Robyn; Lee, Kenneth; Liu, Lei


    This study was aimed at testing the applicability of modified Weber number scaling with Alaska North Slope (ANS) crude oil, and developing a Reynolds number scaling approach for oil droplet size prediction for high viscosity oils. Dispersant to oil ratio and empirical coefficients were also quantified. Finally, a two-step Rosin-Rammler scheme was introduced for the determination of droplet size distribution. This new approach appeared more advantageous in avoiding the inconsistency in interfacial tension measurements, and consequently delivered concise droplet size prediction. Calculated and observed data correlated well based on Reynolds number scaling. The relation indicated that chemical dispersant played an important role in reducing the droplet size of ANS under different seasonal conditions. The proposed Reynolds number scaling and two-step Rosin-Rammler approaches provide a concise, reliable way to predict droplet size distribution, supporting decision making in chemical dispersant application during an offshore oil spill.

  13. Distribution of radionuclides in an iron calibration standard for a free release measurement facility.

    Hult, Mikael; Stroh, Heiko; Marissens, Gerd; Tzika, Faidra; Lutter, Guillaume; Šurán, Jiri; Kovar, Petr; Skala, Lukas; Sud, Jaromír


    A Europallet-sized calibration standard composed of 12 grey cast iron tubes contaminated with (60)Co and (110m)Ag with a mass of 246kg was developed. As the tubes were produced through centrifugal casting it was of particular concern to study the distribution of radionuclides in the radial direction of the tubes. This was done by removing 72 small samples (swarf) of ~0.3g each on both the inside and outside of the tubes. All of the samples were measured in the underground laboratory HADES.

  14. Cellular cholesterol distribution influences proteolytic release of the LRP-1 ectodomain

    Bassil eDEKKY


    Full Text Available Low-Density Lipoprotein Receptor-related Protein-1 (LRP-1 is a multifunctional matricellular receptor composed of a large ligand-binding subunit (515-kDa α-chain associated with a short trans-membrane subunit (85-kDa β-chain. LRP-1, which exhibits both endocytosis and cell signaling properties, plays a key role in tumor invasion by regulating the activity of proteinases such as matrix metalloproteinases (MMPs. LRP-1 is shed at the cell surface by proteinases such as membrane-type 1 MMP (MT1-MMP and a disintegrin and metalloproteinase-12 (ADAM-12. Here we show by using biophysical, biochemical and cellular imaging approaches that efficient extraction of cell cholesterol and increased LRP-1 shedding occur in MDA-MB-231 breast cancer cells but not in MDA-MB-435 cells. Our data show that cholesterol is differently distributed in both cell lines; predominantly intracellularly for MDA-MB-231 cells and at the plasma membrane for MDA-MB-435 cells. This study highlights the relationship between the rate and cellular distribution of cholesterol and its impact on LRP-1 shedding modulation. Altogether, our data strongly suggest that the increase of LRP-1 shedding upon cholesterol depletion induces a higher accessibility of the sheddase substrate, ie LRP-1, at the cell surface rather than an increase of expression of the enzyme.

  15. Generalized multidimensional earthquake frequency distributions consistent with Non-Extensive Statistical Physics: An appraisal of the universality in the interdependence of magnitude, interevent time and interevent distance

    Tzanis, Andreas; Vallianatos, Philippos; Efstathiou, Angeliki


    strong line of evidence that the statistics of frequency vs. interevent distance is also compliant with NESP. Finally, recent work has indicated that on the assumption that the statistical distributions of Magnitude M and Interevent Time Δt and Interevent Distance ΔD are due to independent processes in the sense that the joint probability p(M, Δt, ΔD) factorizes into the probabilities of M, Δt and ΔD, i.e. p(M,Δt,ΔD)= p(M)p(Δt)p(ΔD), earthquake frequency is multiply related, not only to magnitude as the G-R law predicts, but also to the interevent time and distance by means of well defined power-laws consistent with NESP. This means that the four-dimensional hypercube formed by the joint distribution of earthquake frequency, magnitude, interevent time and interevent distance comprises a generalized distribution of the G-R type which epitomizes the temporal and spatial interdependence of earthquake activity, consistent with expectation for complex (stationary or evolutionary) critical system. The above findings have attributes of universality, i.e. they are expected to hold true at all spatial, temporal and magnitude scales. The present work is an empirical attempt to explore the hypothesis of universality by investigating their validity and applicability to regional seismicity data from different seismotectonic regions of the world. Hitherto, the results are encouraging and appear to confirm the hypothesis. Acknowledgments. This work was partly supported by the THALES Program of the Ministry of Education of Greece and the European Union in the framework of the project "Integrated understanding of Seismicity, using innovative methodologies of Fracture Mechanics along with Earthquake and Non-Extensive Statistical Physics - Application to the geodynamic system of the Hellenic Arc - SEISMO FEAR HELLARC".

  16. Estimation of critical current distribution in Bi2Sr2CaCu2O x cables and coils using a self-consistent model

    Liu, Donghui; Xia, Jing; Yong, Huadong; Zhou, Youhe


    Superconducting magnets can generate high magnetic fields. Multi-filamentary Ag-alloy sheathed Bi2Sr2CaCu2O x (Bi-2212) round wire can have a high critical current density in a very high magnetic field. Thus, Bi-2212 has great potential for the development of high-field magnets. For safe and reliable operation of superconducting magnets, it is necessary to estimate the critical current during the design of cables and coils. In this paper, we extend the self-consistent model proposed by Zermeño et al to study the critical current of Bi-2212 cables and coils. First, based on the distribution of Bi-2212 filaments and the experimental test of the critical current of a single strand, the critical currents in cables and coils are calculated. The self-field effect on the critical current is also analyzed. Then, we use an equivalent model to to estimate critical current of large superconducting coils. The equivalent model can effectively estimate the critical current in coils. Using the equivalent model, the results of coils in self-field and high field are compared and discussed. The method and results could be useful for the design of high-field coils.

  17. Ocean dynamic processes causing spatially heterogeneous distribution of sedimentary caesium-137 massively released from the Fukushima Daiichi Nuclear Power Plant

    Higashi, H.; Morino, Y.; Furuichi, N.; Ohara, T.


    Massive amounts of anthropogenic radiocaesium 137Cs that were released into the environment by the Fukushima Daiichi Nuclear Power Plant accident in March 2011 are widely known to have extensively migrated to Pacific Ocean sediment off of eastern Japan. Several recent reports have stated that the sedimentary 137Cs is now stable with a remarkably heterogeneous distribution. The present study elucidates ocean dynamic processes causing this heterogeneous sedimentary 137Cs distribution in and around the shelf off Fukushima and adjacent prefectures. We performed a numerical simulation of oceanic 137Cs behaviour for about 10 months after the accident, using a comprehensive dynamic model involving advection-diffusion transport in seawater, adsorption and desorption to and from particulate matter, sedimentation and suspension on and from the bottom, and vertical diffusion transport in the sediment. A notable simulated result was that the sedimentary 137Cs significantly accumulated in a swath just offshore of the shelf break (along the 50-100 m isobath) as in recent observations, although the seabed in the entire simulation domain was assumed to have ideal properties such as identical bulk density, uniform porosity, and aggregation of particles with a single grain diameter. This result indicated that the heterogeneous sedimentary 137Cs distribution was not necessarily a result of the spatial distribution of 137Cs sediment adsorptivity. The present simulation suggests that the shape of the swath is mainly associated with spatiotemporal variation between bottom shear stress in the shallow shelf (< 50 m depths) and that offshore of the shelf break. In a large part of the shallow shelf, the simulation indicated that strong bottom friction suspending particulate matter from the seabed frequently occurred via a periodic spring tide about every 2 weeks and via occasional strong wind. The sedimentary 137Cs thereby could hardly stay on the surface of the seabed with the result that

  18. The Influence of Canal Water Releases on the Distribution of Methylmercury in Everglades National Park: Implications for Ecosystem Restoration

    Krabbenhoft, D. P.; Aiken, G.; Orem, W.; Tate, M. T.; Kline, J.; Castro, J.


    Elevated levels of mercury (Hg) in the food web of the Florida Everglades have been well recognized for about two decades. Researchers have revealed the vexing complexity of ecosystem-scale factors that control Hg bioaccumulation across the Everglades, including: land use, elevated levels of atmospheric Hg deposition, water use and management, and disturbances (e.g., fire and droughts). Many of these factors directly interface with the Everglades Restoration Program; a fifteen year effort to return this unique ecosystem to a condition more closely resembling the historical uninterrupted flow way from Lake Okeechobee to Florida Bay. However, some activities of the Everglades restoration plan may result in exacerbated methylmercury (MeHg) production due to chemical and hydrologic effects on methylation. Specifically, planned increasing amounts of canal water releases, rich in sulfate and dissolved organic carbon (DOC), to the southern most part of the Everglades (Everglades National Park, ENP). In addition, with a more “natural” flow regime, regions of the ENP may also experience more frequent wetting and drying cycles, a phenomenon known to stimulate MeHg production in the Everglades and elsewhere. In the past two years, the U.S. Geological Survey and the National Park Service have been undertaking annual surveys of surface water and forage fish from about 70 sites across the ENP. The project is designed to assess the distribution and occurrence of MeHg across the ENP, and relate it to the major factors that affect Hg methylation discussed above. Results from the analysis of fish and water samples clearly show that canal water travels through ENP along the Shark River Slough, the historical center of flow through the Everglades. Several chemical makers of the canal water are evident, including sulfate, chloride and fluoride. Also evident in the data is a significant increase in the abundance of MeHg along the Shark River Slough, and direct result of sulfate

  19. The Rucio Consistency Service

    Serfon, Cedric; The ATLAS collaboration


    One of the biggest challenge with Large scale data management system is to ensure the consistency between the global file catalog and what is physically on all storage elements. To tackle this issue, the Rucio software which is used by the ATLAS Distributed Data Management system has been extended to automatically handle lost or unregistered files (aka Dark Data). This system automatically detects these inconsistencies and take actions like recovery or deletion of unneeded files in a central manner. In this talk, we will present this system, explain the internals and give some results.

  20. Investigation of Blade-row Flow Distributions in Axial-flow-compressor Stage Consisting of Guide Vanes and Rotor-blade Row

    Mahoney, John J; Dugan, Paul D; Budinger, Raymond E; Goelzer, H Fred


    A 30-inch tip-diameter axial-flow compressor stage was investigated with and without rotor to determine individual blade-row performance, interblade-row effects, and outer-wall boundary-layer conditions. Velocity gradients at guide-vane outlet without rotor approximated design assumptions, when the measured variation of leaving angle was considered. With rotor in operation, Mach number and rotor-blade effects changed flow distribution leaving guide vanes and invalidated design assumption of radial equilibrium. Rotor-blade performance correlated interpolated two-dimensional results within 2 degrees, although tip stall was indicated in experimental and not two-dimensional results. Boundary-displacement thickness was less than 1.0 and 1.5 percent of passage height after guide vanes and after rotor, respectively, but increased rapidly after rotor when tip stall occurred.

  1. The Distribution of the Asymptotic Number of Citations to Sets of Publications by a Researcher or From an Academic Department Are Consistent With a Discrete Lognormal Model

    Moreira, João A G; Amaral, Luís A Nunes


    How to quantify the impact of a researcher's or an institution's body of work is a matter of increasing importance to scientists, funding agencies, and hiring committees. The use of bibliometric indicators, such as the h-index or the Journal Impact Factor, have become widespread despite their known limitations. We argue that most existing bibliometric indicators are inconsistent, biased, and, worst of all, susceptible to manipulation. Here, we pursue a principled approach to the development of an indicator to quantify the scientific impact of both individual researchers and research institutions grounded on the functional form of the distribution of the asymptotic number of citations. We validate our approach using the publication records of 1,283 researchers from seven scientific and engineering disciplines and the chemistry departments at the 106 U.S. research institutions classified as "very high research activity". Our approach has three distinct advantages. First, it accurately captures the overall scien...

  2. Distribution of corticotropin-releasing factor neurons in the mouse brain: a study using corticotropin-releasing factor-modified yellow fluorescent protein knock-in mouse.

    Kono, Junko; Konno, Kohtarou; Talukder, Ashraf Hossain; Fuse, Toshimitsu; Abe, Manabu; Uchida, Katsuya; Horio, Shuhei; Sakimura, Kenji; Watanabe, Masahiko; Itoi, Keiichi


    We examined the morphological features of corticotropin-releasing factor (CRF) neurons in a mouse line in which modified yellow fluorescent protein (Venus) was expressed under the CRF promoter. We previously generated the CRF-Venus knock-in mouse, in which Venus is inserted into the CRF gene locus by homologous recombination. In the present study, the neomycin phosphotransferase gene (Neo), driven by the pgk-1 promoter, was deleted from the CRF-Venus mouse genome, and a CRF-Venus∆Neo mouse was generated. Venus expression is much more prominent in the CRF-Venus∆Neo mouse when compared to the CRF-Venus mouse. In addition, most Venus-expressing neurons co-express CRF mRNA. Venus-expressing neurons constitute a discrete population of neuroendocrine neurons in the paraventricular nucleus of the hypothalamus (PVH) that project to the median eminence. Venus-expressing neurons were also found in brain regions outside the neuroendocrine PVH, including the olfactory bulb, the piriform cortex (Pir), the extended amygdala, the hippocampus, the neocortices, Barrington's nucleus, the midbrain/pontine dorsal tegmentum, the periaqueductal gray, and the inferior olivary nucleus (IO). Venus-expressing perikarya co-expressing CRF mRNA could be observed clearly even in regions where CRF-immunoreactive perikarya could hardly be identified. We demonstrated that the CRF neurons contain glutamate in the Pir and IO, while they contain gamma-aminobutyric acid in the neocortex, the bed nucleus of the stria terminalis, the hippocampus, and the amygdala. A population of CRF neurons was demonstrated to be cholinergic in the midbrain tegmentum. The CRF-Venus∆Neo mouse may be useful for studying the structural and functional properties of CRF neurons in the mouse brain.

  3. Two-component density functional theory within the projector augmented-wave approach: Accurate and self-consistent computations of positron lifetimes and momentum distributions

    Wiktor, Julia; Jomard, Gérald; Torrent, Marc


    Many techniques have been developed in the past in order to compute positron lifetimes in materials from first principles. However, there is still a lack of a fast and accurate self-consistent scheme that could handle accurately the forces acting on the ions induced by the presence of the positron. We will show in this paper that we have reached this goal by developing the two-component density functional theory within the projector augmented-wave (PAW) method in the open-source code abinit. This tool offers the accuracy of the all-electron methods with the computational efficiency of the plane-wave ones. We can thus deal with supercells that contain few hundreds to thousands of atoms to study point defects as well as more extended defects clusters. Moreover, using the PAW basis set allows us to use techniques able to, for instance, treat strongly correlated systems or spin-orbit coupling, which are necessary to study heavy elements, such as the actinides or their compounds.

  4. Releasing Pattern of Applied Phosphorus and Distribution Change of Phosphorus Fractions in the Acid Upland Soils with Successive Resin Extraction

    Arief Hartono


    Full Text Available The releasing pattern of applied P in the acid upland soils and the soil properties influencing the pattern were studied. Surface horizons of six acid upland soils from Sumatra, Java and Kalimantan were used in this study. The releasing pattern of applied P (300 mg P kg-1 of these soils were studied by successive resin extraction. P fractionation was conducted to evaluate which fractions released P to the soil solution after successive resin extraction. The cumulative of resin-Pinorganic (Pi release of soils was fitted to the first order kinetic. Regression analyses using factor scores obtained from the previous principal components analyses was applied to determine soil properties influencing P releasing pattern. The results suggested that the maximum P release was significantly (P < 0.05 increased by acidity plus 1.4 nm mineral-related factor (PC2 i.e. exchangeable Al and 1.4 nm minerals (smectite and vermiculite and decreased by oxide related factor (PC1 i.e. aluminum (Al plus 1/2 iron (Fe (by ammonium oxalate, crystalline Al and Fe oxides, cation exchange capacity, and clay content. P fractionation analysis after successive resin extraction showed that both labile and less labile in the form of NaHCO3-Pi and NaOH-Pi fractions, respectively, can be transformed into resin-Pi when in the most labile resin-Pi is depleted. Most of P released in high oxides soils were from NaOH-Pi fraction while in low oxides soils were from NaHCO3-Pi. P release from the former fraction resulted in the maximum P release lower than that of the latter one. When NaHCO3-Pi was high, NaOH-Pi was relatively more stable than NaHCO3-Pi despite resin-Pi removal. NaHCO3-Pi and NaOH-Pi are very important P fractions in replenishing resin-Pi in these acid upland soils.

  5. Combining scenarios in a calculation of the overall probability distribution of cumulative releases of radioactivity from the Waste Isolation Pilot Plant, southeastern New Mexico

    Tierney, M.S.


    The Waste Isolation Pilot Plant (WIPP), in southeastern New Mexico, is a research and development facility to demonstrate safe disposal of defense-generated transuranic waste. The US Department of Energy will designate WIPP as a disposal facility if it meets the US Environmental Protection Agency's standard for disposal of such waste; the standard includes a requirement that estimates of cumulative releases of radioactivity to the accessible environment be incorporated in an overall probability distribution. The WIPP Project has chosen an approach to calculation of an overall probability distribution that employs the concept of scenarios for release and transport of radioactivity to the accessible environment. This report reviews the use of Monte Carlo methods in the calculation of an overall probability distribution and presents a logical and mathematical foundation for use of the scenario concept in such calculations. The report also draws preliminary conclusions regarding the shape of the probability distribution for the WIPP system; preliminary conclusions are based on the possible occurrence of three events and the presence of one feature: namely, the events attempted boreholes over rooms and drifts,'' mining alters ground-water regime,'' water-withdrawal wells provide alternate pathways,'' and the feature brine pocket below room or drift.'' Calculation of the WIPP systems's overall probability distributions for only five of sixteen possible scenario classes that can be obtained by combining the four postulated events or features.

  6. Aerosol Types using Passive Remote Sensing: Global Distribution, Consistency Check, Total-Column Investigation and Translation into Composition Derived from Climate and Chemical Transport Model

    Kacenelenbogen, M. S.; Dawson, K. W.; Johnson, M. S.; Burton, S. P.; Redemann, J.; Hasekamp, O. P.; Hair, J. W.; Ferrare, R. A.; Butler, C. F.; Holben, B. N.; Beyersdorf, A. J.; Ziemba, L. D.; Froyd, K. D.; Dibb, J. E.; Shingler, T.; Sorooshian, A.; Jimenez, J. L.; Campuzano Jost, P.; Jacob, D. J.


    To improve the predictions of aerosol composition in chemical transport models (CTMs) and global climate models (GCMs), we have developed an aerosol classification algorithm (called Specified Clustering and Mahalanobis Classification, SCMC) that assigns an aerosol type to multi-parameter retrievals by spaceborne, airborne or ground based passive remote sensing instruments [Russell et al., 2014]. The aerosol types identified by our scheme are pure dust, polluted dust, urban-industrial/developed economy, urban-industrial/developing economy, dark biomass smoke, light biomass smoke and pure marine. We apply the SCMC method to two different total-column datasets of aerosol optical properties: inversions from the ground-based AErosol RObotic NETwork (AERONET) and retrievals from the space-borne POLDER (Polarization and Directionality of Earth's Reflectances) instrument. The POLDER retrievals that we use differ from the standard POLDER retrievals [Deuzé et al., 2001] as they make full use of multi-angle, multispectral polarimetric data [Hasekamp et al., 2011]. We analyze agreement in the aerosol types inferred from both AERONET and POLDER globally. Then, we investigate how our total-column "effective" SCMC aerosol types relate to different aerosol types within the column (i.e. either a mixture of different types within one layer in the vertical or the stacking of different aerosol types within the vertical column). For that, we compare AERONET-SCMC aerosol types to collocated NASA LaRC HSRL vertically resolved aerosol types [Burton et al., 2012] during the SEAC4RS and DISCOVER-AQ airborne field experiments, mostly over Texas in Aug-Sept 2013. Finally, in order to evaluate the GEOS-Chem CTM aerosol types, we translate each of our SCMC aerosol type into a unique distribution of GEOS-Chem aerosol composition (e.g. biomass burning, dust, sulfate, sea salt). We bridge the gap between remote sensing and model-inferred aerosol types by using multiple years of collocated AERONET

  7. Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: estimation of the UV filter distribution and release behaviour in skin layers.

    Vettor, M; Bourgeois, S; Fessi, H; Pelletier, J; Perugini, P; Pavanetto, F; Bolzinger, M A


    New formulation strategies have to be developed to limit the skin penetration of UV-filter. Nanoparticles (NP) are very suitable for that purpose. In this study, the skin distribution, at different times (1, 2 and 3 h), of octyl-methoxycinnamate (OMC) from loaded PLA-nanoparticles was compared to a classical formulation containing non-encapsulated OMC, using the Franz cell method. The results showed that the OMC penetration was clearly impeded by stratum corneum and that the major part of the OMC-NP was accumulated at the skin surface (> 80%). A significant lower OMC amount was quantified in viable skin with NP compared to the OMC emulgel. To accurately determine the real OMC amount in close contact with viable skin layers two solvents were used to extract OMC from the skin compartments. Acetone (ACET) allowed quantifying both OMC in NP and OMC released from the particles, while isopropylmyristate (IPM), a non-solvent of the NP polymer (PLA), allowed quantifying only OMC released from the particles. Using IPM as an extraction solvent, it appeared that the OMC released from NP, in contact with viable skin, was 3-fold lower than free OMC diffused from the emulgel. Lastly, a sustained release was observed when nanoparticles were used.

  8. Carbon 14 distribution in irradiated BWR fuel cladding and released carbon 14 after aqueous immersion of 6.5 years

    Sakuragi, T. [Radioactive Waste Management Funding and Research Center, Tsukishima 1-15-7, Chuo City, Tokyo, 104-0052 (Japan); Yamashita, Y.; Akagi, M.; Takahashi, R. [TOSHIBA Corporation, Ukishima Cho 4-1, Kawasaki Ward, Kawasaki, 210-0862 (Japan)


    Spent fuel cladding which is highly activated and strongly contaminated is expected to be disposed of in an underground repository. A typical activation product in the activated metal waste is carbon 14 ({sup 14}C), which is mainly generated by the {sup 14}N(n,p){sup 14}C reaction and produces a significant exposure dose due to the large inventory, long half-life (5730 years), rapid release rate, and the speciation and consequent migration parameters. In the preliminary Japanese safety case, the release of radionuclides from the metal matrix is regarded as the corrosion-related congruent release, and the cladding oxide layer is regarded as a source of instant release fraction (IRF). In the present work, specific activity of {sup 14}C was measured using an irradiated BWR fuel cladding (Zircaloy-2, average rod burnup of 41.6 GWd/tU) which has an external oxide film having a thickness of 25.3 μm. The {sup 14}C specific activity of the base metal was 1.49*10{sup 4} Bq/g, which in the corresponding burnup is comparable to values in the existing literature, which were obtained from various irradiated claddings. Although the specific activity in oxide was 2.8 times the base metal activity due to the additive generation by the {sup 17}O(n,α){sup 14}C reaction, the {sup 14}C abundance in oxide was less than 10% of total inventory. A static leaching test using the cladding tube was carried out in an air-tight vessel filled with a deoxygenated dilute NaOH solution (pH of 12.5) at room temperature. After 6.5 years, {sup 14}C was found in each leachate fraction of gas phase and dissolved organics and inorganics, the total of which was less than 0.01% of the {sup 14}C inventory of the immersed cladding tube. A simple calculation based on the congruent release with Zircaloy corrosion has suggested that the 96.7% of released {sup 14}C was from the external oxide layer and 3.3% was from the base Zircaloy metal. However, both the {sup 14}C abundance and the low leaching rate

  9. A Probe into Management Modes for Logistics Distribution Consistent Operations in the Circumstance of the Internet of Things%物联网环境下物流配送一贯化作业管理模式新探



    The internet of things is a newly-developed technology, which significantly influences logistics distribution. In light of the problems in logistics distribution operation such as nonstandard order processing, inefficient goods inventory, high manpower demand for loading and unloading operation, irrational distribution lines and poor capacity of real-time tracking of goods distribution, etc., the article develops management modes for logistics distribution consistent operations in the circumstance of the internet of things, and realize coherent intelligent distribution operation process: order processing → distribution and tally →loading and unloading →goods storing →delivery and transportation → delivery services in an effort to improve logistics distribution efficiency and cut down logistics costs.%物联网作为一种新兴技术,对物流配送有重要影响。针对物流配送作业中存在订单处理不规范、货物盘点效率低、仓库装卸搬运人力需求高、配送线路不合理、实时跟踪货物配送情况能力差等问题,构建基于物联网环境下物流配送一贯化作业管理模式,实现从订单处理、配货理货、搬运装卸、储存、运输送货、送达服务等连贯化的智能配送作业过程,加快货物在物流过程中的流通速度,减少人工操作失误,对提高物流配送效率和降低物流成本具有重要意义。

  10. A Monte Carlo procedure for the construction of complementary cumulative distribution functions for comparison with the EPA release limits for radioactive waste disposal

    Helton, J.C.; Shiver, A.W.


    A Monte Carlo procedure for the construction of complementary cumulative distribution functions (CCDFs) for comparison with the US Environmental Protection Agency (EPA) release limits for radioactive waste disposal (40 CFR 191, Subpart B) is described and illustrated with results from a recent performance assessment (PA) for the Waste Isolation Pilot Plant (WIPP). The Monte Carlo procedure produces CCDF estimates similar to those obtained with stratified sampling in several recent PAs for the WIPP. The advantages of the Monte Carlo procedure over stratified sampling include increased resolution in the calculation of probabilities for complex scenarios involving drilling intrusions and better use of the necessarily limited number of mechanistic calculations that underlie CCDF construction.

  11. Release of accumulated arsenic from distribution pipes into tap water after arsenic treatment of source water- presentation

    Toxic arsenic (As) is known to incorporate from source well water onto the scales of distribution system pipes such as iron, copper, galvanized steel and even plastic containing internal buildup of iron coatings (Lytle et al., 2010, 2004; Schock, 2015; Reiber and Dostal, 2000). W...

  12. Identification and distribution of gonadotropin-releasing hormone-like peptides in the brain of horseshoe crab Tachypleus tridentatus

    HUANG Huiyang; LI Linming; YE Haihui; FENG Biyun; LI Shaojing


    Gonadotropin-releasing hormone (GnRH) is a crucial peptide for the regulation of reproduction.Using immunological techniques,we investigated the presence of GnRH in horseshoe crab Tachypleus tridentatus.Octopus GnRH-like immunoreactivity,tunicate GnRH-like immunoreactivity,and lamprey GnRH-I-like immunoreactivity were detected in the neurons and fibers of the protocerebrum.However,no mammal GnRH-like immunoreactivity or lamprey GnRH-Ⅲ-like immunoreactivity was observed.Our results suggest that a GnRH-like factor,an ancient peptide,existed in the brain of T.tridentatus and may be involved in the reproductive endocrine system.

  13. Sensitivity Analysis of Flow and Temperature Distributions of Density Currents in a River-Reservoir System under Upstream Releases with Different Durations

    Gang Chen


    Full Text Available A calibrated three-dimensional Environmental Fluid Dynamics Code model was applied to simulate unsteady flow patterns and temperature distributions in the Bankhead river-reservoir system in Alabama, USA. A series of sensitivity model runs were performed under daily repeated large releases (DRLRs with different durations (2, 4 and 6 h from Smith Dam Tailrace (SDT when other model input variables were kept unchanged. The density currents in the river-reservoir system form at different reaches, are destroyed at upstream locations due to the flow momentum of the releases, and form again due to solar heating. DRLRs (140 m3/s with longer durations push the bottom cold water further downstream and maintain a cooler bottom water temperature. For the 6-h DRLR, the momentum effect definitely reaches Cordova (~43.7 km from SDT. Positive bottom velocity (density currents moving downstream is achieved 48.4%, 69.0% and 91.1% of the time with an average velocity of 0.017, 0.042 and 0.053 m/s at Cordova for the 2-h, 4-h and 6-h DRLR, respectively. Results show that DRLRs lasting for at least 4 h maintain lower water temperatures at Cordova. When the 4-h and 6-h DRLRs repeat for more than 6 and 10 days, respectively, bottom temperatures at Cordova become lower than those for the constant small release (2.83 m3/s. These large releases overwhelm the mixing effects due to inflow momentum and maintain temperature stratification at Cordova.

  14. Time-dependent density functional theory (TD-DFT) coupled with reference interaction site model self-consistent field explicitly including spatial electron density distribution (RISM-SCF-SEDD)

    Yokogawa, D.


    Theoretical approach to design bright bio-imaging molecules is one of the most progressing ones. However, because of the system size and computational accuracy, the number of theoretical studies is limited to our knowledge. To overcome the difficulties, we developed a new method based on reference interaction site model self-consistent field explicitly including spatial electron density distribution and time-dependent density functional theory. We applied it to the calculation of indole and 5-cyanoindole at ground and excited states in gas and solution phases. The changes in the optimized geometries were clearly explained with resonance structures and the Stokes shift was correctly reproduced.

  15. Chip Multithreaded Consistency Model

    Zu-Song Li; Dan-Dan Huan; Wei-Wu Hu; Zhi-Min Tang


    Multithreaded technique is the developing trend of high performance processor. Memory consistency model is essential to the correctness, performance and complexity of multithreaded processor. The chip multithreaded consistency model adapting to multithreaded processor is proposed in this paper. The restriction imposed on memory event ordering by chip multithreaded consistency is presented and formalized. With the idea of critical cycle built by Wei-Wu Hu, we prove that the proposed chip multithreaded consistency model satisfies the criterion of correct execution of sequential consistency model. Chip multithreaded consistency model provides a way of achieving high performance compared with sequential consistency model and ensures the compatibility of software that the execution result in multithreaded processor is the same as the execution result in uniprocessor. The implementation strategy of chip multithreaded consistency model in Godson-2 SMT processor is also proposed. Godson-2 SMT processor supports chip multithreaded consistency model correctly by exception scheme based on the sequential memory access queue of each thread.

  16. Sorption and phase distribution of ethanol and butanol blended gasoline vapours in the vadose zone after release.

    Ugwoha, Ejikeme; Andresen, John M


    The sorption and phase distribution of 20% ethanol and butanol blended gasoline (E20 and B20) vapours have been examined in soils with varying soil organic matter (SOM) and water contents via laboratory microcosm experiments. The presence of 20% alcohol reduced the sorption of gasoline compounds by soil as well as the mass distribution of the compounds to soil solids. This effect was greater for ethanol than butanol. Compared with the sorption coefficient (Kd) of unblended gasoline compounds, the Kd of E20 gasoline compounds decreased by 54% for pentane, 54% for methylcyclopentane (MCP) and 63% for benzene, while the Kd of B20 gasoline compounds decreased by 39% for pentane, 38% for MCP and 49% for benzene. The retardation factor (R) of E20 gasoline compounds decreased by 53% for pentane, 53% for MCP and 48% for benzene, while the R of B20 gasoline compounds decreased by 39% for pentane, 37% for MCP and 38% for benzene. For all SOM and water contents tested, the Kd and R of all gasoline compounds were in the order of unblended gasoline > B20 > E20, indicating that the use of high ethanol volume in gasoline to combat climate change could put the groundwater at greater risk of contamination.

  17. Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system.

    Liu, Sumei; Gao, Na; Hu, Hong-Zhen; Wang, Xiyu; Wang, Guo-Du; Fang, Xiucai; Gao, Xiang; Xia, Yun; Wood, Jackie D


    Immunofluorescence was used to study immunoreactivity (IR) for corticotropin-releasing factor (CRF) in the guinea pig enteric nervous system. CRF-IR was expressed in both the myenteric and the submucosal plexuses of all regions of the large and small intestine and the myenteric plexus of the stomach. CRF-IR nerve fibers were present in the myenteric and submucosal plexuses, in the circular muscle coat, and surrounding submucosal arterioles. Most of the CRF-IR fibers persisted in the myenteric and submucosal plexuses after 7 days in organotypic culture. CRF-IR was not coexpressed with tyrosine hydroxylase-IR or calcitonin gene-related peptide-IR fibers. The proportions of CRF-IR cell bodies in the myenteric plexus increased progressively from the stomach (0.6%) to the distal colon (2.8%). Most of the CRF-IR myenteric neurons (95%) had uniaxonal morphology; the remainder had Dogiel type II multipolar morphology. CRF-IR cell bodies in the myenteric plexus of the ileum expressed IR for choline acetyltransferase (56.9%), substance P (55.0%), and nitric oxide synthase (37.9%). CRF-IR never colocalized with IR for calbindin, calretinin, neuropeptide Y, serotonin, or somatostatin in the myenteric plexus. CRF-IR cell bodies were more abundant in the submucosal plexus (29.9-38.0%) than in the myenteric plexus. All CRF-IR neurons in submucosal ganglia expressed vasoactive intestinal peptide-IR and were likely to be secretomotor/vasodilator neurons. CRF-IR neurons did not express IR for the CRF(1) receptor. CRF(1)-IR was expressed in neuronal neighbors of those with CRF-IR. Collective evidence suggests that VIPergic secretomotor neurons might provide synaptic input to neighboring cholinergic neurons.

  18. A Bayesian method for characterizing distributed micro-releases: II. inference under model uncertainty with short time-series data.

    Marzouk, Youssef; Fast P. (Lawrence Livermore National Laboratory, Livermore, CA); Kraus, M. (Peterson AFB, CO); Ray, J. P.


    Terrorist attacks using an aerosolized pathogen preparation have gained credibility as a national security concern after the anthrax attacks of 2001. The ability to characterize such attacks, i.e., to estimate the number of people infected, the time of infection, and the average dose received, is important when planning a medical response. We address this question of characterization by formulating a Bayesian inverse problem predicated on a short time-series of diagnosed patients exhibiting symptoms. To be of relevance to response planning, we limit ourselves to 3-5 days of data. In tests performed with anthrax as the pathogen, we find that these data are usually sufficient, especially if the model of the outbreak used in the inverse problem is an accurate one. In some cases the scarcity of data may initially support outbreak characterizations at odds with the true one, but with sufficient data the correct inferences are recovered; in other words, the inverse problem posed and its solution methodology are consistent. We also explore the effect of model error-situations for which the model used in the inverse problem is only a partially accurate representation of the outbreak; here, the model predictions and the observations differ by more than a random noise. We find that while there is a consistent discrepancy between the inferred and the true characterizations, they are also close enough to be of relevance when planning a response.

  19. Fission Fragment Mass Distributions and Total Kinetic Energy Release of 235-Uranium and 238-Uranium in Neutron-Induced Fission at Intermediate and Fast Neutron Energies

    Duke, Dana Lynn [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    This Ph.D. dissertation describes a measurement of the change in mass distributions and average total kinetic energy (TKE) release with increasing incident neutron energy for fission of 235U and 238U. Although fission was discovered over seventy-five years ago, open questions remain about the physics of the fission process. The energy of the incident neutron, En, changes the division of energy release in the resulting fission fragments, however, the details of energy partitioning remain ambiguous because the nucleus is a many-body quantum system. Creating a full theoretical model is difficult and experimental data to validate existing models are lacking. Additional fission measurements will lead to higher-quality models of the fission process, therefore improving applications such as the development of next-generation nuclear reactors and defense. This work also paves the way for precision experiments such as the Time Projection Chamber (TPC) for fission cross section measurements and the Spectrometer for Ion Determination in Fission (SPIDER) for precision mass yields.

  20. Ultraviolet B irradiation induces changes in the distribution and release of arachidonic acid, dihomo-gamma-linolenic acid, and eicosapentaenoic acid in human keratinocytes in culture

    Punnonen, K.; Puustinen, T.; Jansen, C.T.


    There is increasing evidence that derivatives of 20-carbon polyunsaturated fatty acids, the eicosanoids, play an important role in the inflammatory responses of the human skin. To better understand the metabolic fate of fatty acids in the skin, the effect of ultraviolet B (UVB) irradiation (280-320 nm) on the distribution and release of /sup 14/C-labeled arachidonic acid, dihomo-gamma-linolenic acid, and eicosapentaenoic acid in human keratinocytes in culture was investigated. Ultraviolet B irradiation induced the release of all three /sup 14/C-labeled fatty acids from the phospholipids, especially from phosphatidylethanolamine, and this was accompanied by increased labeling of the nonphosphorus lipids. This finding suggests that UVB induces a significant liberation of eicosanoid precursor fatty acids from cellular phospholipids, but the liberated fatty acids are largely reincorporated into the nonphosphorus lipids. In conclusion, the present study suggests that not only arachidonic acid but also dihomo-gamma-linolenic acid, and eicosapentaenoic acid might be involved in the UVB irradiation-induced inflammatory reactions of human skin.

  1. Droplet breakup in subsea oil releases--part 2: predictions of droplet size distributions with and without injection of chemical dispersants.

    Johansen, Øistein; Brandvik, Per Johan; Farooq, Umer


    A new method for prediction of droplet size distributions from subsea oil and gas releases is presented in this paper. The method is based on experimental data obtained from oil droplet breakup experiments conducted in a new test facility at SINTEF. The facility is described in a companion paper, while this paper deals with the theoretical basis for the model and the empirical correlations used to derive the model parameters from the available data from the test facility. A major issue dealt with in this paper is the basis for extrapolation of the data to full scale (blowout) conditions. Possible contribution from factors such as buoyancy flux and gas void fraction are discussed and evaluated based on results from the DeepSpill field experiment.

  2. Exploiting biogeochemical and spectroscopic techniques to assess the geochemical distribution and release dynamics of chromium and lead in a contaminated floodplain soil.

    Rinklebe, Jörg; Shaheen, Sabry M; Schröter, Felix; Rennert, Thilo


    Scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDX) combined with a seven steps sequential extraction technique were used to assess the geochemical distribution of chromium (Cr) and lead (Pb) in a contaminated floodplain soil. Total contents of Cr and Pb were 490.3 and 402.1 mg kg(-1), respectively. The residual fraction was 59.5 and 56.3% of total Cr and Pb. The crystalline iron (Fe) oxide was the dominant non-residual fraction of Cr (35.9% of total Cr). Considerable amounts of Pb were found in the organic fraction (35.4%). Using (13)C nuclear magnetic resonance spectroscopy, the soil organic matter was identified as 48.9% aromatic carbon, which indicated that a certain portion of Pb and Cr might be associated with aromatic compounds. The SEM-EDX images demonstrate a concomitant occurrence of Pb, manganese (Mn), Fe, and aluminum (Al) as well as a coexistence of Cr and Fe. The release dynamics of dissolved Cr and Pb as affected by redox potential (EH), pH, Fe, Mn, dissolved organic carbon, and sulfate was quantified using an automated biogeochemical microcosm apparatus. Soil pH decreased under oxic conditions. The release of Cr, Pb, Fe, and Mn increased under acidic oxic (pH = 3.7, EH = 521 mV) conditions due to the associated decrease of pH (7.1-3.7). The mobilization of Cr and Pb was affected by the Fe and Mn. In conclusion, our multi-technique approach identified the geochemical distribution of Cr and Pb and verified major factors that explain mobilization of Cr and Pb in floodplain soils.

  3. Consistent model driven architecture

    Niepostyn, Stanisław J.


    The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.

  4. Maize varieties released in different eras have similar root length density distributions in the soil, which are negatively correlated with local concentrations of soil mineral nitrogen.

    Peng Ning

    Full Text Available Larger, and deeper, root systems of new maize varieties, compared to older varieties, are thought to have enabled improved acquisition of soil resources and, consequently, greater grain yields. To compare the spatial distributions of the root systems of new and old maize varieties and their relationships with spatial variations in soil concentrations of available nitrogen (N, phosphorus (P and potassium (K, two years of field experiments were performed using six Chinese maize varieties released in different eras. Vertical distributions of roots, and available N, P and K in the 0-60 cm soil profile were determined in excavated soil monoliths at silking and maturity. The results demonstrated that new maize varieties had larger root dry weight, higher grain yield and greater nutrient accumulation than older varieties. All varieties had similar total root length and vertical root distribution at silking, but newer varieties maintained greater total root length and had more roots in the 30-60 cm soil layers at maturity. The spatial variation of soil mineral N (Nmin in each soil horizon was larger than that of Olsen-P and ammonium-acetate-extractable K, and was inversely correlated with root length density (RLD, especially in the 0-20 cm soil layer. It was concluded that greater acquisition of mineral nutrients and higher yields of newer varieties were associated with greater total root length at maturity. The negative relationship between RLD and soil Nmin at harvest for all varieties suggests the importance of the spatial distribution of the root system for N uptake by maize.

  5. Maize varieties released in different eras have similar root length density distributions in the soil, which are negatively correlated with local concentrations of soil mineral nitrogen.

    Ning, Peng; Li, Sa; White, Philip J; Li, Chunjian


    Larger, and deeper, root systems of new maize varieties, compared to older varieties, are thought to have enabled improved acquisition of soil resources and, consequently, greater grain yields. To compare the spatial distributions of the root systems of new and old maize varieties and their relationships with spatial variations in soil concentrations of available nitrogen (N), phosphorus (P) and potassium (K), two years of field experiments were performed using six Chinese maize varieties released in different eras. Vertical distributions of roots, and available N, P and K in the 0-60 cm soil profile were determined in excavated soil monoliths at silking and maturity. The results demonstrated that new maize varieties had larger root dry weight, higher grain yield and greater nutrient accumulation than older varieties. All varieties had similar total root length and vertical root distribution at silking, but newer varieties maintained greater total root length and had more roots in the 30-60 cm soil layers at maturity. The spatial variation of soil mineral N (Nmin) in each soil horizon was larger than that of Olsen-P and ammonium-acetate-extractable K, and was inversely correlated with root length density (RLD), especially in the 0-20 cm soil layer. It was concluded that greater acquisition of mineral nutrients and higher yields of newer varieties were associated with greater total root length at maturity. The negative relationship between RLD and soil Nmin at harvest for all varieties suggests the importance of the spatial distribution of the root system for N uptake by maize.

  6. Modeling benthic-pelagic nutrient exchange processes and porewater distributions in a seasonally-hypoxic sediment: evidence for massive phosphate release by Beggiatoa?

    K. Wallmann


    Full Text Available This study presents benthic data from 12 samplings from February to December 2010 in a 2 m deep channel in the southwest Baltic Sea. In winter, the distribution of solutes in the porewater was strongly modulated by bioirrigation which efficiently flushed the upper 1 cm of sediment, leading to concentrations which varied little from bottom water values. Solute pumping by bioirrigation fell sharply in summer as the bottom waters became severely hypoxic (2. At this point the giant sulfide-oxidizing bacteria Beggiatoa was visible on surface sediments. Despite an increase in O2following mixing of the water column in November, macrofauna remained absent until the end of the sampling. Contrary to expectations, metabolites such as dissolved inorganic carbon, ammonium and hydrogen sulfide did not accumulate in the porewater during the hypoxic period when bioirrigation was absent, but instead tended toward bottom water values. This was taken as evidence for episodic bubbling of methane gas out of the sediment acting as an abiogenic irrigation process. Escaping bubble may provide a pathway for enhanced nutrient release to the bottom water and exacerbate the feedbacks with hypoxia. Subsurface dissolved phosphate (TPO4 peaks in excess of 400 μM developed in autumn resulting in a very large diffusive TPO4 flux to the water column of 0.7 ± 0.2 mmol m−2 d−1. The model was not able to simulate this TPO4 source as release of iron-bound P (Fe–P or organic P. As an alternative hypothesis, the TPO4 peak was reproduced using new kinetic expressions that allow Beggiatoa to take up porewater TPO4 and accumulate an intracellular P pool during periods with oxic bottom waters. TPO4 is then released during hypoxia, as previous published results with sulfide-oxidizing bacteria indicate. The TPO4 added to the porewater over the year by organic P and Fe–P is recycled though Beggiatoa, meaning that no additional source of TPO4 is needed to explain the TPO4 peak

  7. Modeling benthic–pelagic nutrient exchange processes and porewater distributions in a seasonally hypoxic sediment: evidence for massive phosphate release by Beggiatoa?

    K. Wallmann


    Full Text Available This study presents benthic data from 12 samplings from February to December 2010 in a 28 m deep channel in the southwest Baltic Sea. In winter, the distribution of solutes in the porewater was strongly modulated by bioirrigation which efficiently flushed the upper 10 cm of sediment, leading to concentrations which varied little from bottom water values. Solute pumping by bioirrigation fell sharply in the summer as the bottom waters became severely hypoxic (2. At this point the giant sulfide-oxidizing bacteria Beggiatoa was visible on surface sediments. Despite an increase in O2 following mixing of the water column in November, macrofauna remained absent until the end of the sampling. Contrary to expectations, metabolites such as dissolved inorganic carbon, ammonium and hydrogen sulfide did not accumulate in the upper 10 cm during the hypoxic period when bioirrigation was absent, but instead tended toward bottom water values. This was taken as evidence for episodic bubbling of methane gas out of the sediment acting as an abiogenic irrigation process. Porewater–seawater mixing by escaping bubbles provides a pathway for enhanced nutrient release to the bottom water and may exacerbate the feedback with hypoxia. Subsurface dissolved phosphate (TPO4 peaks in excess of 400 μM developed in autumn, resulting in a very large diffusive TPO4 flux to the water column of 0.7 ± 0.2 mmol m−2 d−1. The model was not able to simulate this TPO4 source as release of iron-bound P (Fe–P or organic P. As an alternative hypothesis, the TPO4 peak was reproduced using new kinetic expressions that allow Beggiatoa to take up porewater TPO4 and accumulate an intracellular P pool during periods with oxic bottom waters. TPO4 is then released during hypoxia, as previous published results with sulfide-oxidizing bacteria indicate. The TPO4 added to the porewater over the year by organic P and Fe–P is recycled through Beggiatoa, meaning that no additional source of

  8. Effect of EMIC Wave Normal Angle Distribution on Relativistic Electron Scattering Based on the Newly Developed Self-consistent RC/EMIC Waves Model by Khazanov et al. [2006

    Khazanov, G. V.; Gallagher, D. L.; Gamayunov, K.


    It is well known that the effects of EMIC waves on RC ion and RB electron dynamics strongly depend on such particle/wave characteristics as the phase-space distribution function, frequency, wave-normal angle, wave energy, and the form of wave spectral energy density. Therefore, realistic characteristics of EMIC waves should be properly determined by modeling the RC-EMIC waves evolution self-consistently. Such a selfconsistent model progressively has been developing by Khaznnov et al. [2002-2006]. It solves a system of two coupled kinetic equations: one equation describes the RC ion dynamics and another equation describes the energy density evolution of EMIC waves. Using this model, we present the effectiveness of relativistic electron scattering and compare our results with previous work in this area of research.

  9. No consistent bimetric gravity?

    Deser, S; Waldron, A


    We discuss the prospects for a consistent, nonlinear, partially massless (PM), gauge symmetry of bimetric gravity (BMG). Just as for single metric massive gravity, ultimate consistency of both BMG and the putative PM BMG theory relies crucially on this gauge symmetry. We argue, however, that it does not exist.

  10. Prizes for consistency

    Hiscock, S.


    The importance of consistency in coal quality has become of increasing significance recently, with the current trend towards using coal from a range of sources. A significant development has been the swing in responsibilities for coal quality. The increasing demand for consistency in quality has led to a re-examination of where in the trade and transport chain the quality should be assessed and where further upgrading of inspection and preparation facilities are required. Changes are in progress throughout the whole coal transport chain which will improve consistency of delivered coal quality. These include installation of beneficiation plant at coal mines, export terminals, and on the premises of end users. It is suggested that one of the keys to success for the coal industry will be the ability to provide coal of a consistent quality.

  11. Consistent sets contradict

    Kent, A


    In the consistent histories formulation of quantum theory, the probabilistic predictions and retrodictions made from observed data depend on the choice of a consistent set. We show that this freedom allows the formalism to retrodict several contradictory propositions which correspond to orthogonal commuting projections and which all have probability one. We also show that the formalism makes contradictory probability one predictions when applied to generalised time-symmetric quantum mechanics.

  12. Ocean dynamic processes causing spatially heterogeneous distribution of sedimentary caesium-137 massively released from the Fukushima Dai-ichi Nuclear Power Plant

    H. Higashi


    Full Text Available Massive amounts of anthropogenic radiocaesium 137Cs that was released into the environment by the Fukushima Dai-ichi Nuclear Power Plant accident on March 2011 are widely known to have extensively migrated to Pacific oceanic sediment off of east Japan. Several recent reports have stated that the sedimentary 137Cs is now stable with a remarkably heterogeneous distribution. The present study elucidates ocean dynamic processes causing this heterogeneous sedimentary 137Cs distribution in and around the shelf off Fukushima and adjacent prefectures. We performed a numerical simulation of oceanic 137Cs behaviour for about 10 months after the accident, using a comprehensive dynamic model involving advection–diffusion transport in seawater, adsorption and desorption to and from particulate matter, sedimentation and suspension on and from the bottom, and vertical diffusion transport in the sediment. A notable simulated result was that the sedimentary 137Cs significantly accumulated in a swath just offshore of the shelf break (along the 50–100 m isobath as in recent observations, although the seabed in the entire simulation domain was assumed to have ideal properties such as identical bulk density, uniform porosity, and aggregation of particles with a single grain diameter. This result indicated that the heterogeneous sedimentary 137Cs distribution was not necessarily a result of the spatial distribution of 137Cs sediment adsorptivity. The present simulation suggests that the shape of the swath is mainly associated with spatiotemporal variation between bottom shear stress in the shallow shelf (137Cs thereby could hardly stay on the surface of the seabed with the result that the simulated sediment-surface 137Cs activity tended to decrease steadily for a long term after the initial 137Cs migration. By contrast, in the offshore region, neither the spring tide nor the strong wind caused bottom disturbance. Hence, the particulate matter incorporated with

  13. Changes in distribution patterns of 0-group bivalves in the Wadden Sea: Byssus-drifting releases juveniles from the constraints of hydrography

    Armonies, W.


    grain size distribution and tidal level within the area studied. On a scale of hundreds of metres, there were no consistent correlations between juvenile abundance and sediment granulometry in any species. In summary, it seems that hydrography ruled the initial settlement of larvae to the sediment and strongly influenced the subsequent redistribution of juveniles caused by passive resuspension. The outcome of actively initiated migrations, on the other hand, was only weakly influenced by hydrography. Therefore it is suggested that hydrography plays a dominant role in the initial development of km-scale distributional patterns of just-settled bivalves in the Wadden Sea, while habitat selection is delayed to the byssus-drifting postlarvae phase.

  14. Expectation Consistent Approximate Inference

    Opper, Manfred; Winther, Ole


    We propose a novel framework for approximations to intractable probabilistic models which is based on a free energy formulation. The approximation can be understood from replacing an average over the original intractable distribution with a tractable one. It requires two tractable probability dis...

  15. Network Consistent Data Association.

    Chakraborty, Anirban; Das, Abir; Roy-Chowdhury, Amit K


    Existing data association techniques mostly focus on matching pairs of data-point sets and then repeating this process along space-time to achieve long term correspondences. However, in many problems such as person re-identification, a set of data-points may be observed at multiple spatio-temporal locations and/or by multiple agents in a network and simply combining the local pairwise association results between sets of data-points often leads to inconsistencies over the global space-time horizons. In this paper, we propose a Novel Network Consistent Data Association (NCDA) framework formulated as an optimization problem that not only maintains consistency in association results across the network, but also improves the pairwise data association accuracies. The proposed NCDA can be solved as a binary integer program leading to a globally optimal solution and is capable of handling the challenging data-association scenario where the number of data-points varies across different sets of instances in the network. We also present an online implementation of NCDA method that can dynamically associate new observations to already observed data-points in an iterative fashion, while maintaining network consistency. We have tested both the batch and the online NCDA in two application areas-person re-identification and spatio-temporal cell tracking and observed consistent and highly accurate data association results in all the cases.

  16. Evidence for two modes of water release in Comet 103P/Hartley 2: Distributions of column density, rotational temperature, and ortho-para ratio

    Bonev, Boncho P.; Villanueva, Geronimo L.; Paganini, Lucas; DiSanti, Michael A.; Gibb, Erika L.; Keane, Jacqueline V.; Meech, Karen J.; Mumma, Michael J.


    This paper presents long-slit spectra of H2O emission from the inner coma of Comet 103P/Hartley 2, acquired with NIRSPEC/Keck 2 during the comet's close approach to Earth in 2010. On UT 19.6 October 2010 the slit was oriented nearly orthogonal to the projected (in the plane of the sky) Sun-comet line, and the H2O rotational temperature and column density showed similar spatial distributions as a function of projected distance from the nucleus. On UT 22.5 October, the slit was oriented along the Sun-comet line, and the rotational temperatures revealed pronounced asymmetry while the column densities were nearly symmetric about the nucleus. We suggest this dichotomy reflects two qualitatively different mechanisms of volatile release, which introduce distinct rotational distributions in the sublimated material. Future modeling can test this hypothesis. We also report new retrievals of water nuclear spin species (ortho, para) in this comet, and we present the ortho-to-para ratio (OPR) for various projected nucleocentric distances. Our most precise individual measurement is OPR = 2.59 ± 0.13, corresponding to a nuclear spin temperature (Tspin) of 31 ± 3 K. A weighted mean of five independent measurements provides OPR = 2.79 ± 0.13 (T=37-4+8K). Hartley 2 is the first comet for which the OPR has been measured in multiple apparitions. Our values (in 2010) are in good agreement with those obtained two apparitions earlier by the Infrared Space Observatory. Since the comet lost a substantial amount of material between 1998 and 2010, we see no evidence for variation of the OPR with depth in the nucleus. Further discussion of the advantages, assumptions, and biases introduced by various approaches when quantifying nuclear spin species (observing techniques, models and model parameters, sources of uncertainty) would likely aid in interpreting the OPRs measured in cometary volatiles.

  17. Reporting consistently on CSR

    Thomsen, Christa; Nielsen, Anne Ellerup


    of a case study showing that companies use different and not necessarily consistent strategies for reporting on CSR. Finally, the implications for managerial practice are discussed. The chapter concludes by highlighting the value and awareness of the discourse and the discourse types adopted......This chapter first outlines theory and literature on CSR and Stakeholder Relations focusing on the different perspectives and the contextual and dynamic character of the CSR concept. CSR reporting challenges are discussed and a model of analysis is proposed. Next, our paper presents the results...... in the reporting material. By implementing consistent discourse strategies that interact according to a well-defined pattern or order, it is possible to communicate a strong social commitment on the one hand, and to take into consideration the expectations of the shareholders and the other stakeholders...

  18. A Magnetic Consistency Relation

    Jain, Rajeev Kumar


    If cosmic magnetic fields are indeed produced during inflation, they are likely to be correlated with the scalar metric perturbations that are responsible for the Cosmic Microwave Background anisotropies and Large Scale Structure. Within an archetypical model of inflationary magnetogenesis, we show that there exists a new simple consistency relation for the non-Gaussian cross correlation function of the scalar metric perturbation with two powers of the magnetic field in the squeezed limit where the momentum of the metric perturbation vanishes. We emphasize that such a consistency relation turns out to be extremely useful to test some recent calculations in the literature. Apart from primordial non-Gaussianity induced by the curvature perturbations, such a cross correlation might provide a new observational probe of inflation and can in principle reveal the primordial nature of cosmic magnetic fields.

  19. Geometrically Consistent Mesh Modification

    Bonito, A.


    A new paradigm of adaptivity is to execute refinement, coarsening, and smoothing of meshes on manifolds with incomplete information about their geometry and yet preserve position and curvature accuracy. We refer to this collectively as geometrically consistent (GC) mesh modification. We discuss the concept of discrete GC, show the failure of naive approaches, and propose and analyze a simple algorithm that is GC and accuracy preserving. © 2010 Society for Industrial and Applied Mathematics.

  20. Consistent wind Facilitates Vection

    Masaki Ogawa


    Full Text Available We examined whether a consistent haptic cue suggesting forward self-motion facilitated vection. We used a fan with no blades (Dyson, AM01 providing a wind of constant strength and direction (wind speed was 6.37 m/s to the subjects' faces with the visual stimuli visible through the fan. We used an optic flow of expansion or contraction created by positioning 16,000 dots at random inside a simulated cube (length 20 m, and moving the observer's viewpoint to simulate forward or backward self-motion of 16 m/s. we tested three conditions for fan operation, which were normal operation, normal operation with the fan reversed (ie, no wind, and no operation (no wind and no sound. Vection was facilitated by the wind (shorter latency, longer duration and larger magnitude values with the expansion stimuli. The fan noise did not facilitate vection. The wind neither facilitated nor inhibited vection with the contraction stimuli, perhaps because a headwind is not consistent with backward self-motion. We speculate that the consistency between multi modalities is a key factor in facilitating vection.

  1. 分布式交互系统中连续媒体的延迟一致性模型%Delayed Consistency Model for Distributed Interactive Systems with Real-Time Continuous Media



    The advanced multimedia and high-speed networks make distributed interactive systems more promising and practical. These systems are distributed systems, which allow many clients located in different locations to concurrently explore and interact with each other. The systems can be built either in the localarea network (LAN), or the wide area network (WAN), such as the Internet. Operations issued at one site are immediately executed at the local sites for a good response time, and are propagated to other sites. One of the challenging issues raised in the systems is consistency maintenance. Such issue in the discrete interactive media has been studied in many literatures. However, the consistency maintenance scheme for discrete interactive media is not suitable for continuous media domain. This paper illustrates a consistency problem in continuous interactive media by a simple example. The absolute consistency model, a strong requirement, is suitable for LAN and results in a bad responsiveness in WAN. To make themodel more practical for WAN, a new consistency model, named delayed consistency model (DCM), is proposed. In this model, if an operation on an object x is issued at site i, every site is required to execute the operation at a specified time. The essential idea behind the proposed model is that other sites are enforced to update the state at a certain amount of time later than site i does. Thus, other sites will finally view the same state of x as that of site i. The DCM model is flexible, since it is unnecessary for all sites to have the identical delayed time. In case that the system is based on a real-time network, another advantage of the model is providing the real-time network scheduling with important timing parameters.%随着多媒体和网络技术的发展,分布式交互系统被广泛应用.在这种系统中,多个客户端通过局域或广域网交互连接.为使响应时间短,本地节点产生的操作立即在本地

  2. Infanticide and moral consistency.

    McMahan, Jeff


    The aim of this essay is to show that there are no easy options for those who are disturbed by the suggestion that infanticide may on occasion be morally permissible. The belief that infanticide is always wrong is doubtfully compatible with a range of widely shared moral beliefs that underlie various commonly accepted practices. Any set of beliefs about the morality of abortion, infanticide and the killing of animals that is internally consistent and even minimally credible will therefore unavoidably contain some beliefs that are counterintuitive.

  3. Self-consistent triaxial models

    Sanders, Jason L


    We present self-consistent triaxial stellar systems that have analytic distribution functions (DFs) expressed in terms of the actions. These provide triaxial density profiles with cores or cusps at the centre. They are the first self-consistent triaxial models with analytic DFs suitable for modelling giant ellipticals and dark haloes. Specifically, we study triaxial models that reproduce the Hernquist profile from Williams & Evans (2015), as well as flattened isochrones of the form proposed by Binney (2014). We explore the kinematics and orbital structure of these models in some detail. The models typically become more radially anisotropic on moving outwards, have velocity ellipsoids aligned in Cartesian coordinates in the centre and aligned in spherical polar coordinates in the outer parts. In projection, the ellipticity of the isophotes and the position angle of the major axis of our models generally changes with radius. So, a natural application is to elliptical galaxies that exhibit isophote twisting....

  4. Ocean dynamic processes causing spatially heterogeneous distribution of sedimentary caesium-137 massively released from the Fukushima Dai-ichi Nuclear Power Plant

    Higashi, H.; Morino, Y.; Furuichi, N.; Ohara, T.


    Massive amounts of anthropogenic radiocaesium 137Cs that was released into the environment by the Fukushima Dai-ichi Nuclear Power Plant accident on March 2011 are widely known to have extensively migrated to Pacific oceanic sediment off of east Japan. Several recent reports have stated that the sedimentary 137Cs is now stable with a remarkably heterogeneous distribution. The present study elucidates ocean dynamic processes causing this heterogeneous sedimentary 137Cs distribution in and around the shelf off Fukushima and adjacent prefectures. We performed a numerical simulation of oceanic 137Cs behaviour for about 10 months after the accident, using a comprehensive dynamic model involving advection-diffusion transport in seawater, adsorption and desorption to and from particulate matter, sedimentation and suspension on and from the bottom, and vertical diffusion transport in the sediment. A notable simulated result was that the sedimentary 137Cs significantly accumulated in a swath just offshore of the shelf break (along the 50-100 m isobath) as in recent observations, although the seabed in the entire simulation domain was assumed to have ideal properties such as identical bulk density, uniform porosity, and aggregation of particles with a single grain diameter. This result indicated that the heterogeneous sedimentary 137Cs distribution was not necessarily a result of the spatial distribution of 137Cs sediment adsorptivity. The present simulation suggests that the shape of the swath is mainly associated with spatiotemporal variation between bottom shear stress in the shallow shelf (< 50 m depths) and that offshore of the shelf break. In a large part of the shallow shelf, the simulation indicated that strong bottom friction suspending particulate matter from the seabed frequently occurred via a periodic spring tide about every 2 weeks and via occasional strong wind. The sedimentary 137Cs thereby could hardly stay on the surface of the seabed with the result that

  5. When is holography consistent?

    McInnes, Brett, E-mail: [National University of Singapore (Singapore); Ong, Yen Chin, E-mail: [Nordita, KTH Royal Institute of Technology and Stockholm University, Roslagstullsbacken 23, SE-106 91 Stockholm (Sweden)


    Holographic duality relates two radically different kinds of theory: one with gravity, one without. The very existence of such an equivalence imposes strong consistency conditions which are, in the nature of the case, hard to satisfy. Recently a particularly deep condition of this kind, relating the minimum of a probe brane action to a gravitational bulk action (in a Euclidean formulation), has been recognized; and the question arises as to the circumstances under which it, and its Lorentzian counterpart, is satisfied. We discuss the fact that there are physically interesting situations in which one or both versions might, in principle, not be satisfied. These arise in two distinct circumstances: first, when the bulk is not an Einstein manifold and, second, in the presence of angular momentum. Focusing on the application of holography to the quark–gluon plasma (of the various forms arising in the early Universe and in heavy-ion collisions), we find that these potential violations never actually occur. This suggests that the consistency condition is a “law of physics” expressing a particular aspect of holography.

  6. 聚类和情感分布相结合的微博热点事件发现%Micro-Blog Hot Event Detection which consist of Text Clustering and Emotion Distribution

    陈江锋; 初凌峰


    With the quick development of the Internet and Micro-Blog, the public sentiment in the Micro-blog has receive more and more attention. As Micro-Blog has its own characteristics, traditional technology of event detection can't meet our needs. In this paper, we propose an algorithm which consist text clustering and emotion distribution. This paper add emotion analysis into the traditional event detection method to auxiliary decision, to judge whether there is a hot event happening by analysis the change of emotion words. Experiment results show that the mothod proposed can detect hot events in Micro-Blog platform effectively, facilitating the monitoring and management of the hot events in Micro-Blog platform.%随着互互联网和微博的高速发展,微博中的舆情信息已经越来越受到关注。由于微博自有的一些特点,传统的事件发现技术在微博中难以得到理想的效果。本文提出了一种聚类和情感分布相结合的事件发现方法。本文在传统的事件发现方法中加入情感分析以辅助决策,通过分析情感词的变化判断是否有热点事件发生。实验结果表明本文方法可以有效的在徽博平台当中发现热点事件,有助于对微博中舆情的监控和管理。

  7. Consistent quantum measurements

    Griffiths, Robert B.


    In response to recent criticisms by Okon and Sudarsky, various aspects of the consistent histories (CH) resolution of the quantum measurement problem(s) are discussed using a simple Stern-Gerlach device, and compared with the alternative approaches to the measurement problem provided by spontaneous localization (GRW), Bohmian mechanics, many worlds, and standard (textbook) quantum mechanics. Among these CH is unique in solving the second measurement problem: inferring from the measurement outcome a property of the measured system at a time before the measurement took place, as is done routinely by experimental physicists. The main respect in which CH differs from other quantum interpretations is in allowing multiple stochastic descriptions of a given measurement situation, from which one (or more) can be selected on the basis of its utility. This requires abandoning a principle (termed unicity), central to classical physics, that at any instant of time there is only a single correct description of the world.

  8. Effect of growth hormone-releasing peptide on ardiac cholinergic nerve fiber density distribution in a rat model of heart failure

    Guozhong Tian; Xiuqin Ni; Yong Zhao; Jia Feng; Yanjun Li; Zhenya Zhong; Shuling Bai


    BACKGROUND: Changes in the cardiac autonomic nerve are considered to be important factors in the mechanisms of heart failure. It is possible to reduce or slow down nerve degeneration and necrosis, provided that patients take effective neuroprotectants during the early stages of heart failure. Moreover, it is possible to relieve the pathological process and reduce the risk of death.OBJECTIVE: To study the effect of growth hormone releasing peptide (GHRP) on cardiac cholinergic nerve fiber density distribution in a rat model of heart failure, and verify whether GHRP can ameliorate denervation.DESIGN, TIME AND SETTING: A randomized controlled study was performed at the Key Laboratory of Anatomy, Harbin Medical University, between June and October 2009.MATERIALS: Fifty adult, healthy, female, Wistar rats, weighing (200±20) g, were randomly divided into GHRP (n=30), model (n=10), and sham operation (n=10) groups. GHRP-2 was made in Shanghai, China (batch No. z071212-03).METHODS: Acute myocardial infarction was established by ligating the left anterior descending coronary artery in the GHRP and model groups. Five weeks later, myocardial function was detected using color ultrasound electrocardiograph. Ejection fraction < 60% was considered to be a successful marker of chronic heart failure models. However, the left anterior descending coronary artery was not ligated in the sham operation group. The GHRP group was injected with 100μg/kg GHRP-2, and the other two groups were injected with the same volume of physiological saline, once per day.MAIN OUTCOME MEASURES: After 4 weeks, pathological changes in cardiac cholinergic nerve fibers were detected under optic microscopy following hematoxylin/eosin staining. In addition, density distribution was measured using a multi-function color pathological image system.RESULTS: In the sham operation group, myocardial cells were regular, uniformly stained, and no inflammatory cells were present. In the model group, myocardial cells

  9. When Is Holography Consistent?

    McInnes, Brett


    Holographic duality relates two radically different kinds of theory: one with gravity, one without. The very existence of such an equivalence imposes strong consistency conditions which are, in the nature of the case, hard to satisfy. Recently a particularly deep condition of this kind, relating the minimum of a probe brane action to a gravitational bulk action (in a Euclidean formulation), has been recognised; and the question arises as to the circumstances under which it, and its Lorentzian counterpart, are satisfied. We discuss the fact that there are physically interesting situations in which one or both versions might, in principle, \\emph{not} be satisfied. These arise in two distinct circumstances: first, when the bulk is not an Einstein manifold, and, second, in the presence of angular momentum. Focusing on the application of holography to the quark-gluon plasma (of the various forms arising in the early Universe and in heavy-ion collisions), we find that these potential violations never actually occur...

  10. Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus)

    Illing, Nicola; Troskie, Brigitte E.; Nahorniak, Carol S.; Janet P Hapgood; Peter, Richard E.; Millar, Robert P.


    In the goldfish (Carassius auratus) the two endogenous forms of gonadotropin-releasing hormone (GnRH), namely chicken GnRH II ([His5,Trp7,Tyr8]GnRH) and salmon GnRH ([Trp7,Leu8]GnRH), stimulate the release of both gonadotropins and growth hormone from the pituitary. This control is thought to occur by means of the stimulation of distinct GnRH receptors. These receptors can be distinguished on the basis of differential gonadotropin and growth hormone releasing activities of naturally occurring...

  11. Consistent estimators in random censorship semiparametric models



    For the fixed design regression modelwhen Y, are randomly censored on the right, the estimators of unknown parameter and regression function g from censored observations are defined in the two cases .where the censored distribution is known and unknown, respectively. Moreover, the sufficient conditions under which these estimators are strongly consistent and pth (p>2) mean consistent are also established.

  12. Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries

    Wisselink, H.J.; Smith, H.E.; Stockhofe-Zurwieden, N.; Peperkamp, K.; Vecht, U.


    Streptococcus suis strains (n=411), isolated from diseased pigs in seven European countries were serotyped using specific antisera against serotype 1 to 28, and were phenotyped on the basis of their muramidase-released-protein (MRP) and extracellular-factor protein (EF) production. Overall, S. suis

  13. Distribution of the Formosa strain of the fire ant decapitating fly Pseudacteon curvatus (Diptera: Phoridae) three and a half years after releases in North Florida

    The Formosa biotype of the decapitating fly Pseudacteon curvatus Borgmeier was released and successfully established as a self-sustaining biocontrol agent of the red imported fire ant Solenopsis invicta Buren at several sites around Gainesville, FL in 2003. In order to determine the status of these...

  14. The mechanism of protein release from triglyceride microspheres.

    Zaky, A; Elbakry, A; Ehmer, A; Breunig, M; Goepferich, A


    The purpose of this study was to reveal factors that have an impact on the protein release kinetics from triglyceride microspheres prepared by spray congealing. We investigated the effect of protein particle size, morphology and distribution on protein release from microspheres by confocal laser scanning microscopy (CLSM)(.) The microspheres were loaded with three types of model particles made of FITC-labeled bovine serum albumin: freeze dried protein, spherical particles obtained by precipitation in the presence of PEG and micronized material. Investigation by light microscopy and laser light diffraction revealed that the freeze dried material consisted mainly of app. 29 μm elongated shaped particles. The precipitated BSA consisted mainly of 9.0 μm diameter spherically shaped particles while the micronized protein prepared by jet milling consisted of 4.9 μm sized rounded particles of high uniformity. Microspheres were embedded into a cold-curing resin and cut with a microtome. Subsequent investigation by CLSM revealed major differences of distribution of the polydisperse protein particles inside the microsphere sections depending on the type of BSA that was used. Particles of micronized and precipitated protein were distributed almost throughout the microsphere cross section. The protein distribution had a marked impact on the release kinetics in phosphate buffer. Large protein particles led to a considerably faster release than small ones. By staining the release medium we demonstrated that in all three cases there was a strong correlation between protein release and buffer intrusion. Copyright © 2010 Elsevier B.V. All rights reserved.

  15. Decentralized Consistent Updates in SDN

    Nguyen, Thanh Dang


    We present ez-Segway, a decentralized mechanism to consistently and quickly update the network state while preventing forwarding anomalies (loops and blackholes) and avoiding link congestion. In our design, the centralized SDN controller only pre-computes information needed by the switches during the update execution. This information is distributed to the switches, which use partial knowledge and direct message passing to efficiently realize the update. This separation of concerns has the key benefit of improving update performance as the communication and computation bottlenecks at the controller are removed. Our evaluations via network emulations and large-scale simulations demonstrate the efficiency of ez-Segway, which compared to a centralized approach, improves network update times by up to 45% and 57% at the median and the 99th percentile, respectively. A deployment of a system prototype in a real OpenFlow switch and an implementation in P4 demonstrate the feasibility and low overhead of implementing simple network update functionality within switches.

  16. Modifications of imaging spectroscopy methods for increases spatial and temporal consistency: A case study of change in leafy spurge distribution between 1999 and 2001 in Theodore Roosevelt National Park, North Dakota

    Dudek, Kathleen Burke

    The noxious weed leafy spurge (Euphorbia esula L.) has spread throughout the northern Great Plains of North America since it was introduced in the early 1800s, and it is currently a significant management concern. Accurate, rapid location and repeatable measurements are critical for successful temporal monitoring of infestations. Imaging spectroscopy is well suited for identification of spurge; however, the development and dissemination of standardized hyperspectral mapping procedures that produce consistent multi-temporal maps has been absent. Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data, collected in 1999 and 2001 over Theodore Roosevelt National Park, North Dakota, were used to locate leafy spurge. Published image-processing methods were tested to determine the most successful for consistent maps. Best results were obtained using: (1) NDVI masking; (2) cross-track illumination correction; (3) image-derived spectral libraries; and (4) mixture-tuned matched filtering algorithm. Application of the algorithm was modified to standardize processing and eliminate threshold decisions; the image-derived library was refined to eliminate additional variability. Primary (spurge dominant), secondary (spurge non-dominant), abundance, and area-wide vegetation maps were produced. Map accuracies were analyzed with point, polygon, and grid reference sets, using confusion matrices and regression between field-measured and image-derived abundances. Accuracies were recalculated after applying a majority filter, and buffers ranging from 1-5 pixels wide around classified pixels, to accommodate poor reference-image alignment. Overall accuracy varied from 39% to 82%, however, regression analyses yielded r2 = 0.725, indicating a strong relationship between field and image-derived densities. Accuracy was sensitive to: (1) registration offsets between field and image locations; (2) modification of analytical methods; and (3) reference data quality. Sensor viewing angle

  17. The distribution of Elongation Factor-1 Alpha (EF-1alpha), Elongation Factor-Like (EFL), and a non-canonical genetic code in the ulvophyceae: discrete genetic characters support a consistent phylogenetic framework.

    Gile, Gillian H; Novis, Philip M; Cragg, David S; Zuccarello, Giuseppe C; Keeling, Patrick J


    The systematics of the green algal class Ulvophyceae have been difficult to resolve with ultrastructural and molecular phylogenetic analyses. Therefore, we investigated relationships among ulvophycean orders by determining the distribution of two discrete genetic characters previously identified only in the order Dasycladales. First, Acetabularia acetabulum uses the core translation GTPase Elongation Factor 1alpha (EF-1alpha) while most Chlorophyta instead possess the related GTPase Elongation Factor-Like (EFL). Second, the nuclear genomes of dasycladaleans A. acetabulum and Batophora oerstedii use a rare non-canonical genetic code in which the canonical termination codons TAA and TAG instead encode glutamine. Representatives of Ulvales and Ulotrichales were found to encode EFL, while Caulerpales, Dasycladales, Siphonocladales, and Ignatius tetrasporus were found to encode EF-1alpha, in congruence with the two major lineages previously proposed for the Ulvophyceae. The EF-1alpha of I. tetrasporus supports its relationship with Caulerpales/Dasycladales/Siphonocladales, in agreement with ultrastructural evidence, but contrary to certain small subunit rRNA analyses that place it with Ulvales/Ulotrichales. The same non-canonical genetic code previously described in A. acetabulum was observed in EF-1alpha sequences from Parvocaulis pusillus (Dasycladales), Chaetomorpha coliformis, and Cladophora cf. crinalis (Siphonocladales), whereas Caulerpales use the universal code. This supports a sister relationship between Siphonocladales and Dasycladales and further refines our understanding of ulvophycean phylogeny.

  18. The Top-Dog Index: A New Measurement for the Demand Consistency of the Size Distribution in Pre-Pack Orders for a Fashion Discounter with Many Small Branches

    Kurz, Sascha; Schluechtermann, Joerg; Wolf, Rainer


    We propose the new Top-Dog-Index, a measure for the branch-dependent historic deviation of the supply data of apparel sizes from the sales data of a fashion discounter. A common approach is to estimate demand for sizes directly from the sales data. This approach may yield information for the demand for sizes if aggregated over all branches and products. However, as we will show in a real-world business case, this direct approach is in general not capable to provide information about each branch's individual demand for sizes: the supply per branch is so small that either the number of sales is statistically too small for a good estimate (early measurement) or there will be too much unsatisfied demand neglected in the sales data (late measurement). Moreover, in our real-world data we could not verify any of the demand distribution assumptions suggested in the literature. Our approach cannot estimate the demand for sizes directly. It can, however, individually measure for each branch the scarcest and the amplest...

  19. Construction of calcium release sites in cardiac myocytes

    Alexandra eZahradnikova


    Full Text Available Local character of calcium release in cardiac myocytes, as defined by confocal recordings of calcium sparks, implies independent activation of individual calcium release sites based on ryanodine receptor (RyR channel recruitment. We constructed virtual calcium release sites (vCRSs composed of a variable number of RyR channels distributed in clusters in accordance with the experimentally observed cluster size distribution. The vCRSs consisted either of a single virtual calcium release unit, in which all clusters shared a common dyadic space, or of multiple virtual calcium release units containing one cluster each and having separate dyadic spaces. We explored the stochastic behavior of vCRSs to understand the activation and recruitment of RyRs during calcium sparks. RyRs were represented by the published allosteric gating model that included regulation by cytosolic Ca2+ and Mg2+. The interaction of Mg2+ with the RyR Ca2+-binding sites and the refractory period of vCRSs were optimized to accord with the experimentally observed calcium dependence of calcium spark frequency. The Mg2+-binding parameters of RyRs that provided the best description of spark frequency depended on the number of RyRs assembled in the virtual calcium release sites. Adequate inhibitory effect of Mg2+ on the calcium dependence of RyR open probability was achieved if the virtual calcium release sites contained at least three clusters. For the distribution of the number of open RyRs in evoked calcium sparks to correspond to the experimentally observed distribution of spark calcium release fluxes, at least 3 clusters had to share a common virtual calcium release unit, in which ~ 3 RyRs open to form an average spark. These results reconcile the small cluster size and stochastic placement of RyRs in the release sites with the estimates of the amount of RyR protein, volume density of calcium release sites, and the size of calcium release sites in rat cardiac myocytes.

  20. Tracer distribution in the Pacific Ocean following a release off Japan – what does an oceanic general circulation model tell us?

    I. Kriest


    Full Text Available In the aftermath of an earthquake and tsunami on 11 March 2011 considerable amounts of radioactive materials were accidentally released into the sea off Fukushima-Daiichi, Japan. This study uses a three-dimensional eddy-resolving oceanic general circulation model to explore potential pathways of a tracer, similar to 137Cs, from the coast to the open ocean. Results indicate that enhanced concentrations meet a receding spring bloom offshore and that the area of enhanced concentrations offshore is strongly determined by surface mixed layer dynamics. However, huge uncertainties remain. Among them are the realism of the simulated cross-shelf transport and apparently inconsistent estimates of the particle reactivity of 137Cs which are discussed in a brief literature review. We argue that a comprehensive set of 137Cs measurements, including sites offshore, could be a unique opportunity to both evaluate and advance the evaluation of oceanic general circulation models.

  1. Consistency of trace norm minimization

    Bach, Francis


    Regularization by the sum of singular values, also referred to as the trace norm, is a popular technique for estimating low rank rectangular matrices. In this paper, we extend some of the consistency results of the Lasso to provide necessary and sufficient conditions for rank consistency of trace norm minimization with the square loss. We also provide an adaptive version that is rank consistent even when the necessary condition for the non adaptive version is not fulfilled.

  2. High SNR Consistent Compressive Sensing

    Kallummil, Sreejith; Kalyani, Sheetal


    High signal to noise ratio (SNR) consistency of model selection criteria in linear regression models has attracted a lot of attention recently. However, most of the existing literature on high SNR consistency deals with model order selection. Further, the limited literature available on the high SNR consistency of subset selection procedures (SSPs) is applicable to linear regression with full rank measurement matrices only. Hence, the performance of SSPs used in underdetermined linear models ...

  3. Vertical distribution of Th-isotope ratios, {sup 210}Pb, {sup 226}Ra and {sup 137}Cs in sediment cores from an estuary affected by anthropogenic releases

    San Miguel, E.G.; Bolivar, J.P. [Dpto Fisica Aplicada, E.P.S. La Rabida, Ctra Palos S/N, Huelva 21819 (Spain); Garcia-Tenorio, R. [Dpto Fisica Aplicada, E.T.S. Arquitectura, Avda, Reina Mercedes, 2, Sevilla 41012 (Spain)


    In an estuary system highly polluted by mining and industrial activities, the sections of sediment cores affected by anthropogenic inputs of U-series radionuclides (due to fertilizer plants releases) were determined through the vertical profiles of Th-isotopic ratio ({sup 230}Th/{sup 232}Th). Also, when possible, a modified version of the {sup 210}Pb dating method was applied in the uncontaminated sections of these cores. Using the information provided by the Th-isotopic ratio and {sup 210}Pb methods, we were able to establish confident chronologies, covering the last century, in several of the analysed sediment cores. These chronologies will be used in forthcoming research to study the time evolution of pollutant concentrations in the estuary. Additionally, and based on the established chronologies, we have found that sedimentation rates have drastically increased in some zones of the estuary since the commencement of several industrial activities in the surrounding environment and since the construction of two dikes in the area.

  4. F3/Contactin-Related Proteins in Helix pomatia Nervous Tissue (HCRPs): Distribution and Function in Neurite Growth and Neurotransmitter Release

    Milanese, Chiara; Fiumara, Ferdinando; Bizzoca, Antonella; Giachello, Carlo; Leitinger, Gerd; Gennarini, Gianfranco; Montarolo, Pier Giorgio; Ghirardi, Mirella


    By using antibodies against mouse F3/contactin, we found immunologically related glycoproteins expressed in the nervous tissue of the snail Helix pomatia. Helix contactin-related proteins (HCRPs) include different molecules ranging in size from 90 to 240 kD. Clones isolated from a cDNA expression library allowed us to demonstrate that these proteins are translated from a unique 6.3-kb mRNA, suggesting that their heterogeneity depends on posttranslational processing. This is supported by the results of endoglycosidase F treatment, which indicate that the high-molecular-weight components are glycosylation variants of the 90-kD chain. In vivo and in cultures, HCRPs antibodies label neuronal soma and neurite extensions, giving the appearance of both cytoplasmic and cell surface immunostaining. On the other hand, no expression is found on nonneural tissues. Functionally, HCRPs are involved in neurite growth control and appear to modulate neurotransmitter release, as indicated by the inhibiting effects of specific antibodies on both functions. These data allow the definition of HCRPs glycoproteins as growth-promoting molecules, suggesting that they play a role in neurite development and presynaptic terminal maturation in the invertebrate nervous system. PMID:17941055

  5. Large scale distribution of total mass versus luminous matter from Baryon Acoustic Oscillations: First search in the SDSS-III BOSS Data Release 10

    Soumagnac, M T; Sabiu, C G; Loeb, A; Ross, A J; Abdalla, F B; Balan, S T; Lahav, O


    Baryon Acoustic Oscillations (BAOs) in the early Universe are predicted to leave an as yet undetected signature on the relative clustering of total mass versus luminous matter. A detection of this effect would provide an important confirmation of the standard cosmological paradigm and constrain alternatives to dark matter as well as non-standard fluctuations such as Compensated Isocurvature Perturbations (CIPs). We conduct the first observational search for this effect, by comparing the number-weighted and luminosity-weighted correlation functions, using the SDSS-III BOSS Data Release 10 CMASS sample. When including CIPs in our model, we formally obtain evidence at $3.2\\sigma$ of the relative clustering signature and a limit that matches the existing upper limits on the amplitude of CIPs. However, various tests suggest that these results are not yet robust, perhaps due to systematic biases in the data. The method developed in this Letter, used with more accurate future data such as that from DESI, is likely t...

  6. Testing the enemy release hypothesis: abundance and distribution patterns of helminth communities in grey mullets (Teleostei: Mugilidae) reveal the success of invasive species.

    Sarabeev, Volodimir; Balbuena, Juan Antonio; Morand, Serge


    The abundance and aggregation patterns of helminth communities of two grey mullet hosts, Liza haematocheilus and Mugil cephalus, were studied across 14 localities in Atlantic and Pacific marine areas. The analysis matched parasite communities of (i) L. haematocheilus across its native and introduced populations (Sea of Japan and Sea of Azov, respectively) and (ii) the introduced population of L. haematocheilus with native populations of M. cephalus (Mediterranean, Azov-Black and Japan Seas). The total mean abundance (TMA), as a feature of the infection level in helminth communities, and slope b of the Taylor's power law, as a measure of parasite aggregation at the infra and component-community levels, were estimated and compared between host species and localities using ANOVA. The TMA of the whole helminth community in the introduced population of L. haematocheilus was over 15 times lower than that of the native population, but the difference was less pronounced for carried (monogeneans) than for acquired (adult and larval digeneans) parasite communities. Similar to the abundance pattern, the species distribution in communities from the invasive population of L. haematocheilus was less aggregated than from its native population for endoparasitic helminths, including adult and larval digeneans, while monogeneans showed a similar pattern of distribution in the compared populations of L. haematocheilus. The aggregation level of the whole helminth community, endoparasitic helminths, adult and larval digeneans was lower in the invasive host species in comparison with native ones as shown by differences in the slope b. An important theoretical implication from this study is that the pattern of parasite aggregation may explain the success of invasive species in ecosystems. Because the effects of parasites on host mortality are likely dose-dependent, the proportion of susceptible host individuals in invasive species is expected to be lower, as the helminth distribution in

  7. Consistency argued students of fluid

    Viyanti; Cari; Suparmi; Winarti; Slamet Budiarti, Indah; Handika, Jeffry; Widyastuti, Fatma


    Problem solving for physics concepts through consistency arguments can improve thinking skills of students and it is an important thing in science. The study aims to assess the consistency of the material Fluid student argmentation. The population of this study are College students PGRI Madiun, UIN Sunan Kalijaga Yogyakarta and Lampung University. Samples using cluster random sampling, 145 samples obtained by the number of students. The study used a descriptive survey method. Data obtained through multiple-choice test and interview reasoned. Problem fluid modified from [9] and [1]. The results of the study gained an average consistency argmentation for the right consistency, consistency is wrong, and inconsistent respectively 4.85%; 29.93%; and 65.23%. Data from the study have an impact on the lack of understanding of the fluid material which is ideally in full consistency argued affect the expansion of understanding of the concept. The results of the study as a reference in making improvements in future studies is to obtain a positive change in the consistency of argumentations.

  8. Controlling Iron Release in Drinking Water Distribution System Fed with Desalinated Seawater%淡化海水并网供水的管网铁释放控制技术研究

    米子龙; 张晓健; 陈超; 陈沛君; 杜嘉丹


    Desalinated seawater, with strong corrosiveness, would possibly lead to serious iron release phenomenon and " red water" problem when fed into municipal drinking water distribution systems. To control iron release in the drinking water distribution system, the effect of adjusting pH, alkalinity, hardness and adding inhibitor were investigated in pipe section reactors which were designed to simulate pipe network conditions. The results found that the iron release decreased significantly as increasing pH, alkalinity, hardness and adding polyphosphate inhibitor. Meanwhile, the necessary water quality conditions for controlling iron release were established. The iron control criteria specify that pH, alkalinity and hardness should be more than 7. 70, 80 mg/L and 80 mg/L respectively. 0. 25 to 0. 50 mg/L of polyphosphate inhibitor should be added if necessary.%淡化海水由于具有较强的侵蚀性,并网供水后会对既有供水管网造成严重的铁释放现象和黄水问题.为了有效地控制管网铁释放,利用管段模拟反应器,定量研究了调节pH值、碱度、硬度和投加缓蚀剂对管网铁释放的控制效果.研究发现,提高pH值、增加碱度和硬度、投加磷酸盐缓蚀剂均可使淡化海水并网供水后造成的管网铁释放量明显降低.由此初步确定了控制淡化海水进入供水管网造成铁过量释放所需满足的水质条件为:管网水的pH值在7.70以上,碱度>80 mg/L,硬度>80 mg/L;必要时可选择投加0.25 ~0.50 mg/L的聚磷酸盐缓蚀剂.

  9. Stochastic multicomponent reactive transport analysis of low quality drainage release from waste rock piles: Controls of the spatial distribution of acid generating and neutralizing minerals

    Pedretti, Daniele; Mayer, K. Ulrich; Beckie, Roger D.


    In mining environmental applications, it is important to assess water quality from waste rock piles (WRPs) and estimate the likelihood of acid rock drainage (ARD) over time. The mineralogical heterogeneity of WRPs is a source of uncertainty in this assessment, undermining the reliability of traditional bulk indicators used in the industry. We focused in this work on the bulk neutralizing potential ratio (NPR), which is defined as the ratio of the content of non-acid-generating minerals (typically reactive carbonates such as calcite) to the content of potentially acid-generating minerals (typically sulfides such as pyrite). We used a streamtube-based Monte-Carlo method to show why and to what extent bulk NPR can be a poor indicator of ARD occurrence. We simulated ensembles of WRPs identical in their geometry and bulk NPR, which only differed in their initial distribution of the acid generating and acid neutralizing minerals that control NPR. All models simulated the same principal acid-producing, acid-neutralizing and secondary mineral forming processes. We show that small differences in the distribution of local NPR values or the number of flow paths that generate acidity strongly influence drainage pH. The results indicate that the likelihood of ARD (epitomized by the probability of occurrence of pHuniversally safe; threshold to ensure non-acidic waters in practical applications. Our results suggest that new methods that explicitly account for mineralogical heterogeneity must be sought when computing effective (upscaled) NPR values at the scale of the piles.

  10. Coordinating user interfaces for consistency

    Nielsen, Jakob


    In the years since Jakob Nielsen's classic collection on interface consistency first appeared, much has changed, and much has stayed the same. On the one hand, there's been exponential growth in the opportunities for following or disregarding the principles of interface consistency-more computers, more applications, more users, and of course the vast expanse of the Web. On the other, there are the principles themselves, as persistent and as valuable as ever. In these contributed chapters, you'll find details on many methods for seeking and enforcing consistency, along with bottom-line analys

  11. Consistency of Random Survival Forests.

    Ishwaran, Hemant; Kogalur, Udaya B


    We prove uniform consistency of Random Survival Forests (RSF), a newly introduced forest ensemble learner for analysis of right-censored survival data. Consistency is proven under general splitting rules, bootstrapping, and random selection of variables-that is, under true implementation of the methodology. Under this setting we show that the forest ensemble survival function converges uniformly to the true population survival function. To prove this result we make one key assumption regarding the feature space: we assume that all variables are factors. Doing so ensures that the feature space has finite cardinality and enables us to exploit counting process theory and the uniform consistency of the Kaplan-Meier survival function.

  12. Renin release

    Schweda, Frank; Friis, Ulla; Wagner, Charlotte;


    The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located......, salt, and volume overload. In contrast, the events controlling the function of renin-secreting cells at the organ and cellular level are markedly less clear and remain mysterious in certain aspects. The unravelling of these mysteries has led to new and interesting insights into the process of renin...

  13. Melanin-concentrating hormone (MCH) and gonadotropin-releasing hormones (GnRH) in Atlantic cod, Gadus morhua: tissue distributions, early ontogeny and effects of fasting.

    Tuziak, Sarah M; Volkoff, Hélène


    Melanin-concentrating hormone (MCH) is classically known for its role in regulating teleost fish skin color change for environmental adaptation. Recent evidence suggests that MCH also has appetite-stimulating properties. The gonadotropin-releasing hormone (GnRH) peptide family has dual roles in endocrine control of reproduction and energy status in fish. Atlantic cod (Gadus morhua) are a commercially important aquaculture species inhabiting the shores of Atlantic Canada. In this study, we examine MCH and GnRH transcript expression profiles during early development as well as in central and peripheral tissues and quantify juvenile Atlantic cod MCH and GnRH hypothalamic mRNA expressions following food deprivation. MCH and GnRH3 cDNAs are maternally deposited into cod eggs, while MCH has variable expression throughout early development. GnRH2 and GnRH3 mRNAs "turn-on" during mid-segmentation once the brain is fully developed. For both MCH and GnRH, highest expression appears during the exogenous feeding stages, perhaps supporting their functions as appetite regulators during early development. MCH and GnRH transcripts are found in brain regions related to appetite regulation (telencephalon/preoptic area, optic tectum/thalamus, hypothalamus), as well as the pituitary gland and the stomach, suggesting a peripheral function in food intake regulation. Atlantic cod MCH mRNA is upregulated during fasting, while GnRH2 and GnRH3 transcripts do not appear to be influenced by food deprivation. In conclusion, MCH might be involved in stimulating food intake in juvenile Atlantic cod, while GnRHs may play a more significant role in appetite regulation during early development.

  14. Control Effect of Regulating pH and Alkalinity on Iron Release in Drinking Water Distribution System%调节pH值和碱度对给水管网铁释放的控制作用

    米子龙; 张晓健; 王洋; 陈超; 顾军农


    The control effect of regulating pH and alkalinity on iron release in the drinking water distribution system was investigated. Experiments using the pipe section simulation reactor found that the iron release rate, turbidity and color decreased significantly with increasing pH and alkalinity. Specifically, after increasing pH from 7.6 to 8.2 for 15 d, the iron release rate, turbidity and color decreased by 47% , 54% and 46% , respectively. Meanwhile, increasing alkalinity from 135 mg/L to 260 mg/L (calculated as CaCO3) for 15 d, the iron release rate, turbidity and color decreased by 50% , 58% and 52% , respectively. The cost-effectiveness of regulating pH and alkalinity to control iron release in drinking water was evaluated. The results showed that the cost of regulating pH of finished water was appropriate. This method can be used as an emergency water treatment technology for red water control.%利用管段模拟反应器,定量分析了调节pH值和调节碱度技术对给水管网铁释放的控制作用.研究发现,提高pH值和增加碱度均可使管网铁释放速率、浊度和色度明显降低.调节pH值从7.6增加至8.2,15 d后管网铁释放速率降低了47%,浊度降低了54%,色度降低了46%;调节碱度从135 mg/L增加至260 mg/L(以CaCO3计),15 d后管网铁释放速率降低了50%,浊度降低了58%,色度降低了52%.对比评价了调节pH值和调节碱度技术的经济性,结果表明;调节出厂水pH值控制管网铁释放的经济成本适宜,可作为突发性管网“黄水”问题的应急控制技术.

  15. Process Fairness and Dynamic Consistency

    S.T. Trautmann (Stefan); P.P. Wakker (Peter)


    textabstractAbstract: When process fairness deviates from outcome fairness, dynamic inconsistencies can arise as in nonexpected utility. Resolute choice (Machina) can restore dynamic consistency under nonexpected utility without using Strotz's precommitment. It can similarly justify dynamically

  16. Gravitation, Causality, and Quantum Consistency

    Hertzberg, Mark P


    We examine the role of consistency with causality and quantum mechanics in determining the properties of gravitation. We begin by constructing two different classes of interacting theories of massless spin 2 particles -- gravitons. One involves coupling the graviton with the lowest number of derivatives to matter, the other involves coupling the graviton with higher derivatives to matter, making use of the linearized Riemann tensor. The first class requires an infinite tower of terms for consistency, which is known to lead uniquely to general relativity. The second class only requires a finite number of terms for consistency, which appears as a new class of theories of massless spin 2. We recap the causal consistency of general relativity and show how this fails in the second class for the special case of coupling to photons, exploiting related calculations in the literature. In an upcoming publication [1] this result is generalized to a much broader set of theories. Then, as a causal modification of general ...

  17. Cloud Standardization: Consistent Business Processes and Information

    Razvan Daniel ZOTA


    Full Text Available Cloud computing represents one of the latest emerging trends in distributed computing that enables the existence of hardware infrastructure and software applications as services. The present paper offers a general approach to the cloud computing standardization as a mean of improving the speed of adoption for the cloud technologies. Moreover, this study tries to show out how organizations may achieve more consistent business processes while operating with cloud computing technologies.


    帕丽古丽·木合买提; 艾斯卡尔·艾木都拉


    针对新疆维吾尔自治区高中学业水平考试信息管理系统的使用需求,构造了基于J2EE框架(JSF+ SPRING+ HIBER-NATE)的考籍信息管理子系统结构,根据考籍信息的多文种、多科目和分布式属性,设计了相应的数据采集和发布算法,并用Java 语言实现了全系统及相关算法,解决了分布式海量数据的可靠采集和有效发布问题,从而保证了全区数据的完整性和一致性.实际应用的结果表明,该系统具有较好的可行性、有效性.%To meet the practical requirements of examination information management system of senior middle school education proficiency examination in Xinjiang Uyghur Autonomous Region,the paper designs the examination management sub-system architecture based on J2EE framework (JSF + Spring + Hibernate), then according to the multi-language, multi-curriculum and distributed properties of examination information, designs the corresponding data collection and release algorithms. The entire system and its relative algorithms are programmed with Java. Thus the problems are solved on how to reliably collect and efficiently release distributed mass data so as to guarantee data integrity and consistency of the whole region. Application proves that the system is practical and effective.

  19. Time-consistent and market-consistent evaluations

    Pelsser, A.; Stadje, M.A.


    We consider evaluation methods for payoffs with an inherent financial risk as encountered for instance for portfolios held by pension funds and insurance companies. Pricing such payoffs in a way consistent to market prices typically involves combining actuarial techniques with methods from mathemati

  20. The distribution of substance P and kisspeptin in the mediobasal hypothalamus of the male rhesus monkey and a comparison of intravenous administration of these peptides to release GnRH as reflected by LH secretion

    Kalil, Bruna; Ramaswamy, Suresh; Plant, Tony M.


    Substance P (SP) was recently reported to be expressed in human KNDy neurons and to enhance KNDy neuron excitability in the mouse hypothalamus. We therefore examined 1) interactions of SP and kisspeptin in the mediobasal hypothalamus of adult male rhesus monkeys using immunofluorescence, and 2) the ability of SP to induce LH release in GnRH primed, agonadal juvenile male monkeys. SP cell bodies were observed only occasionally in the arcuate nucleus (Arc), but more frequently dorsal to the Arc in the region of the pre-mammilary nucleus. Castration resulted in an increase in the number of SP cell bodies in the Arc but not in the other nuclei. SP fibers innervated the Arc where they were found in close apposition with kisspeptin perikarya in the periphery of this nucleus. Beaded SP axons projected to the median eminence where they terminated in the external layer and intermingled with beaded kisspeptin axons. Colocalization of the two peptides, however, was not observed. Although close apposition between SP fibers and kisspeptin neurons suggest a role for SP in modulating GnRH pulse generator activity, iv injections of SP failed to elicit release of GnRH (as reflected by LH) in the juvenile monkey. Although the finding of structural interactions between SP and kisspeptin neurons are consistent with the notion that this tachykinin may be involved in regulating pulsatile GnRH release, the apparent absence of expression of SP in KNDy neurons suggests that this peptide is unlikely to be a fundamental component of the primate GnRH pulse generator. PMID:26580201

  1. Market-consistent actuarial valuation

    Wüthrich, Mario V


    This is the third edition of this well-received textbook, presenting powerful methods for measuring insurance liabilities and assets in a consistent way, with detailed mathematical frameworks that lead to market-consistent values for liabilities. Topics covered are stochastic discounting with deflators, valuation portfolio in life and non-life insurance, probability distortions, asset and liability management, financial risks, insurance technical risks, and solvency. Including updates on recent developments and regulatory changes under Solvency II, this new edition of Market-Consistent Actuarial Valuation also elaborates on different risk measures, providing a revised definition of solvency based on industry practice, and presents an adapted valuation framework which takes a dynamic view of non-life insurance reserving risk.

  2. Consistent Histories in Quantum Cosmology

    Craig, David A; 10.1007/s10701-010-9422-6


    We illustrate the crucial role played by decoherence (consistency of quantum histories) in extracting consistent quantum probabilities for alternative histories in quantum cosmology. Specifically, within a Wheeler-DeWitt quantization of a flat Friedmann-Robertson-Walker cosmological model sourced with a free massless scalar field, we calculate the probability that the univese is singular in the sense that it assumes zero volume. Classical solutions of this model are a disjoint set of expanding and contracting singular branches. A naive assessment of the behavior of quantum states which are superpositions of expanding and contracting universes may suggest that a "quantum bounce" is possible i.e. that the wave function of the universe may remain peaked on a non-singular classical solution throughout its history. However, a more careful consistent histories analysis shows that for arbitrary states in the physical Hilbert space the probability of this Wheeler-DeWitt quantum universe encountering the big bang/crun...

  3. The Importance of being consistent

    Wasserman, Adam; Jiang, Kaili; Kim, Min-Cheol; Sim, Eunji; Burke, Kieron


    We review the role of self-consistency in density functional theory. We apply a recent analysis to both Kohn-Sham and orbital-free DFT, as well as to Partition-DFT, which generalizes all aspects of standard DFT. In each case, the analysis distinguishes between errors in approximate functionals versus errors in the self-consistent density. This yields insights into the origins of many errors in DFT calculations, especially those often attributed to self-interaction or delocalization error. In many classes of problems, errors can be substantially reduced by using `better' densities. We review the history of these approaches, many of their applications, and give simple pedagogical examples.

  4. The consistency approach for the quality control of vaccines.

    Hendriksen, Coenraad; Arciniega, Juan L; Bruckner, Lukas; Chevalier, Michel; Coppens, Emmanuelle; Descamps, Johan; Duchêne, Michel; Dusek, David Michael; Halder, Marlies; Kreeftenberg, Hans; Maes, Alexandrine; Redhead, Keith; Ravetkar, Satish D; Spieser, Jean-Marc; Swam, Hanny


    Current lot release testing of conventional vaccines emphasizes quality control of the final product and is characterized by its extensive use of laboratory animals. This report, which is based on the outcome of an ECVAM (European Centre for Validation of Alternative Methods, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy) workshop, discusses the concept of consistency testing as an alternative approach for lot release testing. The consistency approach for the routine release of vaccines is based upon the principle that the quality of vaccines is a consequence of a quality system and of consistent production of lots with similar characteristics to those lots that have been shown to be safe and effective in humans or the target species. The report indicates why and under which circumstances this approach can be applied, the role of the different stakeholders, and the need for international harmonization. It also gives recommendations for its implementation.

  5. Distribution and hosts of arsenic in a sediment core from the Chianan Plain in SW Taiwan: Implications on arsenic primary source and release mechanisms.

    Yang, Huai-Jen; Lee, Chi-Yu; Chiang, Yu-Ju; Jean, Jiin-Shuh; Shau, Yen-Hong; Takazawa, Eiichi; Jiang, Wei-Teh


    High arsenic abundance of 50-700μg/L in the groundwater from the Chianan Plain in southwestern Taiwan is a well-known environmental hazard. The groundwater-associated sediments, however, have not been geochemically characterized, thus hindering a comprehensive understanding of arsenic cycling in this region. In this study, samples collected from a 250m sediment core at the centre of the Chianan Plain were analyzed for arsenic and TOC concentrations (N=158), constituent minerals (N=25), major element abundances (N=105), and sequential arsenic extraction (N=23). The arsenic data show a prevalence of >10mg/kg with higher concentrations of 20-50mg/kg concentrated at 60-80 and 195-210m. Arsenic was extracted mainly as an adsorbate on clay minerals, as a co-precipitate in amorphous iron oxyhydroxide, and as a structural component in clay minerals. Since the sediments consist mainly of quartz, chlorite, and illite, the correlations between arsenic concentration and abundances of K2O and MgO pinpoint illite and chlorite as the major arsenic hosts. The arsenic-total iron correlation reflects the role of chlorite along with the contribution from amorphous iron oxyhydroxide as indicated by arsenic extraction data. Organic matter is not the dominant arsenic host for low TOC content, low arsenic abundance extracted from it, and a relatively low R(2) of the arsenic-TOC correlation. The major constituent minerals in the sediments are the same as those of the upriver metapelites, establishing a sink-source relationship. Composition data from two deep groundwater samples near the sediment core show Eh values and As(V)/As(III) ratios of reducing environments and high arsenic, K, Mg, and Fe contents necessary for deriving arsenic from sediments by desorption from clay and dissolution of iron oxyhydroxide. Therefore, groundwater arsenic was mainly derived from groundwater-associated sediments with limited contributions from other sources, such as mud volcanoes.

  6. Consistent supersymmetric decoupling in cosmology

    Sousa Sánchez, Kepa


    The present work discusses several problems related to the stability of ground states with broken supersymmetry in supergravity, and to the existence and stability of cosmic strings in various supersymmetric models. In particular we study the necessary conditions to truncate consistently a sector o

  7. The ALICE Software Release Validation cluster

    Berzano, D.; Krzewicki, M.


    One of the most important steps of software lifecycle is Quality Assurance: this process comprehends both automatic tests and manual reviews, and all of them must pass successfully before the software is approved for production. Some tests, such as source code static analysis, are executed on a single dedicated service: in High Energy Physics, a full simulation and reconstruction chain on a distributed computing environment, backed with a sample “golden” dataset, is also necessary for the quality sign off. The ALICE experiment uses dedicated and virtualized computing infrastructures for the Release Validation in order not to taint the production environment (i.e. CVMFS and the Grid) with non-validated software and validation jobs: the ALICE Release Validation cluster is a disposable virtual cluster appliance based on CernVM and the Virtual Analysis Facility, capable of deploying on demand, and with a single command, a dedicated virtual HTCondor cluster with an automatically scalable number of virtual workers on any cloud supporting the standard EC2 interface. Input and output data are externally stored on EOS, and a dedicated CVMFS service is used to provide the software to be validated. We will show how the Release Validation Cluster deployment and disposal are completely transparent for the Release Manager, who simply triggers the validation from the ALICE build system's web interface. CernVM 3, based entirely on CVMFS, permits to boot any snapshot of the operating system in time: we will show how this allows us to certify each ALICE software release for an exact CernVM snapshot, addressing the problem of Long Term Data Preservation by ensuring a consistent environment for software execution and data reprocessing in the future.

  8. 硫酸根浓度突变对给水管网铁释放的影响%Effect of sulphate concentration change on iron release in drinking water distribution systems

    米子龙; 张晓健; 陆品品; 陈超; 汪隽; 顾军农


    This study investigated the effect of sulphate concentration changes on the iron release in a drinking water distribution system caused frequently switching of the water source.The rates of iron release from corrosion scale for different water sources were analyzed with pipe section reactors designed to simulate the distribution system flow mode.The results showed that the sulphate concentration was the dominant factor that led to red water.The iron release rate from the corrosion scale correlated well with the sulphate concentration with a sulphate concentration increase from 25 mg/L to 180 mg/L accompanied by a Larson ratio increase from about 0.35 to 1.40.The turbidity in the pipe section reactors increased 6 NTU after 8 h,the color increased 50 degrees and the iron release rate increased 2.00 mg/(m2 · h).These results indicate that the sulphate concentration should be lower than 75 mg/L and the Larson Ratio should be controlled to less than 0.70 for the water quality in the distribution system to meet the Chinese drinking water quality standard.Based on these results,t was suggested to be and controlled less than 0.70 in order that in meet the standard of drinking in China.%针对水源频繁切换造成原水水质硫酸根质量浓度突变对给水管网铁释放的影响开展试验研究.选取北京市城区3个不同地区的管段,设计并制作管段模拟反应器,比较分析不同硫酸根质量浓度水质条件下、不同地区管段的铁释放情况.结果表明:硫酸根质量浓度的大幅增加可导致黄水问题.给水管网铁释放量与硫酸根质量浓度具有显著相关性,当硫酸根质量浓度从25 mg/L增加到180 mg/L,相应的Larson指数从0.35增加到1.40时,8h滞留时间后管段出水浊度、色度的最大增加值分别约为6 NTU和50度,总铁释放速率最大增加约2.00 mg/(m2·h).由此,确定了水源切换条件下,硫酸报和Larson指数对管垢铁释放的控制指标:硫酸根质量浓度<75 mg

  9. Consistence of Network Filtering Rules

    SHE Kun; WU Yuancheng; HUANG Juncai; ZHOU Mingtian


    The inconsistence of firewall/VPN(Virtual Private Network) rule makes a huge maintainable cost.With development of Multinational Company,SOHO office,E-government the number of firewalls/VPN will increase rapidly.Rule table in stand-alone or network will be increased in geometric series accordingly.Checking the consistence of rule table manually is inadequate.A formal approach can define semantic consistence,make a theoretic foundation of intelligent management about rule tables.In this paper,a kind of formalization of host rules and network ones for auto rule-validation based on SET theory were proporsed and a rule validation scheme was defined.The analysis results show the superior performance of the methods and demonstrate its potential for the intelligent management based on rule tables.

  10. On Modal Refinement and Consistency

    Nyman, Ulrik; Larsen, Kim Guldstrand; Wasowski, Andrzej


    Almost 20 years after the original conception, we revisit several fundamental question about modal transition systems. First, we demonstrate the incompleteness of the standard modal refinement using a counterexample due to Hüttel. Deciding any refinement, complete with respect to the standard...... notions of implementation, is shown to be computationally hard (co-NP hard). Second, we consider four forms of consistency (existence of implementations) for modal specifications. We characterize each operationally, giving algorithms for deciding, and for synthesizing implementations, together...

  11. Tri-Sasakian consistent reduction

    Cassani, Davide


    We establish a universal consistent Kaluza-Klein truncation of M-theory based on seven-dimensional tri-Sasakian structure. The four-dimensional truncated theory is an N=4 gauged supergravity with three vector multiplets and a non-abelian gauge group, containing the compact factor SO(3). Consistency follows from the fact that our truncation takes exactly the same form as a left-invariant reduction on a specific coset manifold, and we show that the same holds for the various universal consistent truncations recently put forward in the literature. We describe how the global symmetry group SL(2,R) x SO(6,3) is embedded in the symmetry group E7(7) of maximally supersymmetric reductions, and make the connection with the approach of Exceptional Generalized Geometry. Vacuum AdS4 solutions spontaneously break the amount of supersymmetry from N=4 to N=3,1 or 0, and the spectrum contains massive modes. We find a subtruncation to minimal N=3 gauged supergravity as well as an N=1 subtruncation to the SO(3)-invariant secto...

  12. A Lock—Based Cache Coherence Protocol for Scope Consistency

    胡伟武; 施巍松; 等


    Directory protocols are widely adopted to maintain cache coherence of distributed shared memory multiprocessors.Although scalable to a certain extent,directory protocols are complex enough to prevent it from being used in very large scale multiprocessors with tens of thousands of nodes.his paper proposes a lock-based cache coherence protocol for scope consistency.In does not rely on directory information to maintain cache coherence.Instead,cache coherence is maintained through requiring the releasing processor of a lock to stroe all write-notices generated in the associated critical section to the lock and the acquiring processor invalidates or updates its locally cached data copies according to the write notices of the lock.To evaluate the performance of the lock-based cache coherence protocol,a software SDM system named JIAJIA is built on network of workstations.Besides the lock-based cache coherence protocol,JIAJIA also characterizes itself with its shared memory organization scheme which combines the physical memories of multiple workstations to form a large shared space.Performance measurements with SPLASH2 program suite and NAS benchmarks indicate that,compared to recent SVM systems such as CVM,higher speedup is achieved by JIAJIA.Besides,JIAJIA can solve large scale problems that cannot be solved by other SVM systems due to memory size limitation.

  13. Quantum cosmological consistency condition for inflation

    Calcagni, Gianluca [Instituto de Estructura de la Materia, CSIC, calle Serrano 121, 28006 Madrid (Spain); Kiefer, Claus [Institut für Theoretische Physik, Universität zu Köln, Zülpicher Strasse 77, 50937 Köln (Germany); Steinwachs, Christian F., E-mail:, E-mail:, E-mail: [Physikalisches Institut, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 3, 79104 Freiburg (Germany)


    We investigate the quantum cosmological tunneling scenario for inflationary models. Within a path-integral approach, we derive the corresponding tunneling probability distribution. A sharp peak in this distribution can be interpreted as the initial condition for inflation and therefore as a quantum cosmological prediction for its energy scale. This energy scale is also a genuine prediction of any inflationary model by itself, as the primordial gravitons generated during inflation leave their imprint in the B-polarization of the cosmic microwave background. In this way, one can derive a consistency condition for inflationary models that guarantees compatibility with a tunneling origin and can lead to a testable quantum cosmological prediction. The general method is demonstrated explicitly for the model of natural inflation.

  14. Quantum cosmological consistency condition for inflation

    Calcagni, Gianluca; Steinwachs, Christian F


    We investigate the quantum cosmological tunneling scenario for inflationary models. Within a path-integral approach, we derive the corresponding tunneling probability distribution. A sharp peak in this distribution can be interpreted as the initial condition for inflation and therefore as a quantum cosmological prediction for its energy scale. This energy scale is also a genuine prediction of any inflationary model by itself, as the primordial gravitons generated during inflation leave their imprint in the B-polarization of the cosmic microwave background. In this way, one can derive a consistency condition for inflationary models that guarantees compatibility with a tunneling origin and can lead to a testable quantum cosmological prediction. The general method is demonstrated explicitly for the model of natural inflation.

  15. On the consistency of MPS

    Souto-Iglesias, Antonio; González, Leo M; Cercos-Pita, Jose L


    The consistency of Moving Particle Semi-implicit (MPS) method in reproducing the gradient, divergence and Laplacian differential operators is discussed in the present paper. Its relation to the Smoothed Particle Hydrodynamics (SPH) method is rigorously established. The application of the MPS method to solve the Navier-Stokes equations using a fractional step approach is treated, unveiling inconsistency problems when solving the Poisson equation for the pressure. A new corrected MPS method incorporating boundary terms is proposed. Applications to one dimensional boundary value Dirichlet and mixed Neumann-Dirichlet problems and to two-dimensional free-surface flows are presented.

  16. Measuring process and knowledge consistency

    Edwards, Kasper; Jensen, Klaes Ladeby; Haug, Anders


    with a 5 point Liker scale and a corresponding scoring system. Process consistency is measured by using a first-person drawing tool with the respondent in the centre. Respondents sketch the sequence of steps and people they contact when configuring a product. The methodology is tested in one company...... for granted; rather the contrary, and attempting to implement a configuration system may easily ignite a political battle. This is because stakes are high in the sense that the rules and processes chosen may only reflect one part of the practice, ignoring a majority of the employees. To avoid this situation...

  17. Group Decision-making on Language Distribution Assessment Information and the Consistency Analysis of Decision-making Groups%语言分布评估信息下的群决策方法及其群体一致性分析

    冯建岗; 魏翠萍


    This paper proposes group decision-making method based on the language distribution assessment weighted average operator .It defines the ordered consistency and numerical consistency measure of the evaluation of results between individual decision maker and decision-making groups , for the analysis of the reliability of the evaluation results of decision-making groups .Finally, we prove the effectiveness and practicality of the method with concrete examples and analyzed the ordered consistency and numerical consistency of the evaluation of results between individual decision maker and decision-making groups .%本文提出了基于语言分布评估加权平均( DAWA)算子的多属性群决策方法;定义了个体决策者评价结果与决策群体评价结果的次序一致性和数值一致性测度,以此分析决策群体评价结果的可靠性;最后,通过具体实例验证了群决策方法的有效性和实用性,分析了个体决策者评价结果与决策群体评价结果的次序一致性和数值一致性。

  18. Controls on Fe(II)-Activated Trace Element Release from Goethite and Hematite

    Frierdich, Andrew J.; Catalano, Jeffrey G. (WU)


    Electron transfer and atom exchange (ETAE) between aqueous Fe(II) and Fe(III) oxides induces surface growth and dissolution that affects trace element fate and transport. We have recently demonstrated Ni(II) cycling through goethite and hematite (adsorbed Ni incorporates into the mineral structure and preincorporated Ni releases to solution) during Fe(II)-Fe(III) ETAE. However, the chemical parameters affecting net trace element release remain unknown. Here, we examine the chemical controls on Ni(II) and Zn(II) release from Ni- and Zn-substituted goethite and hematite during reaction with Fe(II). Release follows a rate law consistent with surface reaction limited mineral dissolution and suggests that release occurs near sites of Fe(III) reductive dissolution during Fe(II)-Fe(III) ETAE. Metal substituent type affects reactivity; Zn release is more pronounced from hematite than goethite, whereas the opposite trend occurs for Ni. Buildup of Ni or Zn in solution inhibits further release but this resumes upon fluid exchange, suggesting that sustained release is possible under flow conditions. Mineral and aqueous Fe(II) concentrations as well as pH strongly affect sorbed Fe(II) concentrations, which directly control the reaction rates and final metal concentrations. Our results demonstrate that structurally incorporated trace elements are mobilized from iron oxides into fluids without abiotic or microbial net iron reduction. Such release may affect micronutrient availability, contaminant transport, and the distribution of redox-inactive trace elements in natural and engineered systems.

  19. Bootstrap-Based Inference for Cube Root Consistent Estimators

    Cattaneo, Matias D.; Jansson, Michael; Nagasawa, Kenichi

    This note proposes a consistent bootstrap-based distributional approximation for cube root consistent estimators such as the maximum score estimator of Manski (1975) and the isotonic density estimator of Grenander (1956). In both cases, the standard nonparametric bootstrap is known to be inconsis......This note proposes a consistent bootstrap-based distributional approximation for cube root consistent estimators such as the maximum score estimator of Manski (1975) and the isotonic density estimator of Grenander (1956). In both cases, the standard nonparametric bootstrap is known...

  20. The Consistent Vehicle Routing Problem

    Groer, Christopher S [ORNL; Golden, Bruce [University of Maryland; Edward, Wasil [American University


    In the small package shipping industry (as in other industries), companies try to differentiate themselves by providing high levels of customer service. This can be accomplished in several ways, including online tracking of packages, ensuring on-time delivery, and offering residential pickups. Some companies want their drivers to develop relationships with customers on a route and have the same drivers visit the same customers at roughly the same time on each day that the customers need service. These service requirements, together with traditional constraints on vehicle capacity and route length, define a variant of the classical capacitated vehicle routing problem, which we call the consistent VRP (ConVRP). In this paper, we formulate the problem as a mixed-integer program and develop an algorithm to solve the ConVRP that is based on the record-to-record travel algorithm. We compare the performance of our algorithm to the optimal mixed-integer program solutions for a set of small problems and then apply our algorithm to five simulated data sets with 1,000 customers and a real-world data set with more than 3,700 customers. We provide a technique for generating ConVRP benchmark problems from vehicle routing problem instances given in the literature and provide our solutions to these instances. The solutions produced by our algorithm on all problems do a very good job of meeting customer service objectives with routes that have a low total travel time.

  1. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: Modeling the clustering and halo occupation distribution of BOSS-CMASS galaxies in the Final Data Release

    Rodríguez-Torres, Sergio A; Chuang, Chia-Hsun; Guo, Hong; Klypin, Anatoly; Behroozi, Peter; Hahn, Chang Hoon; Comparat, Johan; Yepes, Gustavo; Montero-Dorta, Antonio D; Brownstein, Joel R; Maraston, Claudia; McBride, Cameron K; Tinker, Jeremy; Gottlöber, Stefan; Favole, Ginevra; Shu, Yiping; Kitaura, Francisco-Shu; Bolton, Adam; Scoccimarro, Román; Samushia, Lado; Schlegel, David; Schneider, Donald P; Thomas, Daniel


    We present a study of the clustering and halo occupation distribution of BOSS CMASS galaxies in the redshift range 0.43 < z < 0.7 drawn from the Final SDSS-III Data Release. We compare the BOSS results with the predictions of a halo abundance matching (HAM) clustering model that assigns galaxies to dark matter halos selected from the large BigMultiDark N-body simulation of a flat $\\Lambda$CDM Planck cosmology. We compare the observational data with the simulated ones on a light-cone constructed from 20 subsequent outputs of the simulation. Observational effects such as incompleteness, geometry, veto masks and fiber collisions are included in the model, which reproduces within 1-$\\sigma$ errors the observed monopole of the 2-point correlation function at all relevant scales{: --} from the smallest scales, 0.5 $h^{-1}$Mpc , up to scales beyond the Baryonic Acoustic Oscillation feature. This model also agrees remarkably well with the BOSS galaxy power spectrum (up to $k\\sim1$ $h$ Mpc$^{-1}$), and the three...

  2. Umatilla Satellite and Release Sites Project : Final Siting Report.

    Montgomery, James M.


    This report presents the results of site analysis for the Umatilla Satellite and Release Sites Project. The purpose of this project is to provide engineering services for the siting and conceptual design of satellite and release facilities for the Umatilla Basin hatchery program. The Umatilla Basin hatchery program consists of artificial production facilities for salmon and steelhead to enhance production in the Umatilla River as defined in the Umatilla master plan approved in 1989 by the Northwest Power Planning Council. Facilities identified in the master plan include adult salmon broodstock holding and spawning facilities, facilities for recovery, acclimation, and/or extended rearing of salmon juveniles, and development of river sites for release of hatchery salmon and steelhead. The historic and current distribution of fall chinook, summer chinook, and coho salmon and steelhead trout was summarized for the Umatilla River basin. Current and future production and release objectives were reviewed. Twenty seven sites were evaluated for the potential and development of facilities. Engineering and environmental attributes of the sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed.

  3. News/Press Releases

    Office of Personnel Management — A press release, news release, media release, press statement is written communication directed at members of the news media for the purpose of announcing programs...

  4. Slip distributions on active normal faults measured from LiDAR and field mapping of geomorphic offsets: an example from L'Aquila, Italy, and implications for modelling seismic moment release

    Wilkinson, Maxwell; Roberts, Gerald P.; McCaffrey, Ken; Cowie, Patience A.; Faure Walker, Joanna P.; Papanikolaou, Ioannis; Phillips, Richard J.; Michetti, Alessandro Maria; Vittori, Eutizio; Gregory, Laura; Wedmore, Luke; Watson, Zoë K.


    Surface slip distributions for an active normal fault in central Italy have been measured using terrestrial laser scanning (TLS), in order to assess the impact of changes in fault orientation and kinematics when modelling subsurface slip distributions that control seismic moment release. The southeastern segment of the surface trace of the Campo Felice active normal fault near the city of L'Aquila was mapped and surveyed using techniques from structural geology and using TLS to define the vertical and horizontal offsets of geomorphic slopes since the last glacial maximum (15 ± 3 ka). The fault geometry and kinematics measured from 43 sites and throw/heave measurements from geomorphic offsets seen on 250 scarp profiles were analysed using a modification of the Kostrov equations to calculate the magnitudes and directions of horizontal principal strain-rates. The map trace of the studied fault is linear, except where a prominent bend has formed to link across a former left-stepping relay-zone. The dip of the fault and slip direction are constant across the bend. Throw-rates since 15 ± 3 ka decrease linearly from the fault centre to the tip, except in the location of the prominent bend where higher throw rates are recorded. Vertical coseismic offsets for two palaeo earthquake ruptures seen as fresh strips of rock at the base of the bedrock scarp also increase within the prominent bend. The principal strain-rate, calculated by combining strike, dip, slip-direction and post 15 ± 3 ka throw rate, decreases linearly from the fault centre towards the tip; the strain-rate does not increase across the prominent fault bend. The above shows that changes in fault strike, whilst having no effect on the principal horizontal strain-rate, can produce local maxima in throw-rates during single earthquakes that persist over the timescale of multiple earthquakes (15 ± 3 ka). Detailed geomorphological and structural characterisation of active faults is therefore a critical

  5. Designing apps for success developing consistent app design practices

    David, Matthew


    In 2007, Apple released the iPhone. With this release came tools as revolutionary as the internet was to businesses and individuals back in the mid- and late-nineties: Apps. Much like websites drove (and still drive) business, so too do apps drive sales, efficiencies and communication between people. But also like web design and development, in its early years and iterations, guidelines and best practices for apps are few and far between.Designing Apps for Success provides web/app designers and developers with consistent app design practices that result in timely, appropriate, and efficiently

  6. Reliability and Consistency of Surface Contamination Measurements

    Rouppert, F.; Rivoallan, A.; Largeron, C.


    Surface contamination evaluation is a tough problem since it is difficult to isolate the radiations emitted by the surface, especially in a highly irradiating atmosphere. In that case the only possibility is to evaluate smearable (removeable) contamination since ex-situ countings are possible. Unfortunately, according to our experience at CEA, these values are not consistent and thus non relevant. In this study, we show, using in-situ Fourier Transform Infra Red spectrometry on contaminated metal samples, that fixed contamination seems to be chemisorbed and removeable contamination seems to be physisorbed. The distribution between fixed and removeable contamination appears to be variable. Chemical equilibria and reversible ion exchange mechanisms are involved and are closely linked to environmental conditions such as humidity and temperature. Measurements of smearable contamination only give an indication of the state of these equilibria between fixed and removeable contamination at the time and in the environmental conditions the measurements were made.

  7. Consistent Stochastic Modelling of Meteocean Design Parameters

    Sørensen, John Dalsgaard; Sterndorff, M. J.


    Consistent stochastic models of metocean design parameters and their directional dependencies are essential for reliability assessment of offshore structures. In this paper a stochastic model for the annual maximum values of the significant wave height, and the associated wind velocity, current...... velocity, and water level is presented. The stochastic model includes statistical uncertainty and dependency between the four stochastic variables. Further, a new stochastic model for annual maximum directional significant wave heights is presented. The model includes dependency between the maximum wave...... height from neighboring directional sectors. Numerical examples are presented where the models are calibrated using the Maximum Likelihood method to data from the central part of the North Sea. The calibration of the directional distributions is made such that the stochastic model for the omnidirectional...

  8. Aggregate distribution, stability and release of water dispersible clay for two subtropical Oxisols Distribuição de agregados, estabilidade e liberação de argila dispersa em água para dois Latossolos subtropicais

    Antonio Carlos de Azevedo


    Full Text Available The behavior of a soil regarding the dispersion and aggregation of its particles is very important for the development of environmental and agricultural soil functions. This study was conducted to determine how aggregate distribution and stability are impacted by land uses and how the release of Water Dispersible Clay (WDC relates to disaggregation in Oxisols from subtropical Brazil. Samples from two Oxisols, collected at three depths from sites under no-tillage (NT, conventional tillage (CT and native vegetation (NV land uses were shaken in 250 mL plastic bottles for intervals up to 27 hours. The mass of aggregates was measured in five size classes ranging from 53 to 2000 µm. Most aggregates larger than 500 mm disappeared during the first 7.5 hours of shaking, concurrent with an increase in WDC release and without change in soil suspension pH and electrical conductivity, without increase in smaller aggregates. Therefore, there is no aggregate hierarchy in these soils and the release of WDC was caused by breaking aggregates within the 500 to 2000 mm range. Land uses affect mass of aggregates in each size class, but the aggregate stability depends on its size, not land use.O comportamento do solo em relação ao seu estado de agregação e dispersão é de alta relevância agrícola e ambiental. Este estudo foi conduzido para determinar como a distribuição e estabilidade de agregados são afetados por diferentes usos e como a liberação de argila dispersa em água (WDC se comporta em relação à desagregação em Latossolos subtropicais brasileiros. Amostras de dois Latossolos coletadas em três profundidades em locais sob plantio direto (NT, plantio convencional (CT e vegetação nativa (NV foram agitados em garrafas plásticas de 250 mL por até 27 horas. A massa de agregados foi medida em cinco classes de tamanho desde 53 até 2000 µm. A maioria dos agregados maiores que 500 mm desapareceu durante as primeiras 7,5 horas de agita

  9. Releasable Asbestos Field Sampler (RAFS) Operation Manual

    The Releasable Asbestos Field Sampler (RAFS) is a field instrument that provides an in-situ measurement of asbestos releasability from consistent and reproducible mechanical agitation of the source material such as soil. The RAFS was designed to measure concentration (asbestos st...

  10. Releasable Asbestos Field Sampler (RAFS) Operation Manual

    The Releasable Asbestos Field Sampler (RAFS) is a field instrument that provides an in-situ measurement of asbestos releasability from consistent and reproducible mechanical agitation of the source material such as soil. The RAFS was designed to measure concentration (asbestos st...

  11. Evaluating Temporal Consistency in Marine Biodiversity Hotspots.

    Piacenza, Susan E; Thurman, Lindsey L; Barner, Allison K; Benkwitt, Cassandra E; Boersma, Kate S; Cerny-Chipman, Elizabeth B; Ingeman, Kurt E; Kindinger, Tye L; Lindsley, Amy J; Nelson, Jake; Reimer, Jessica N; Rowe, Jennifer C; Shen, Chenchen; Thompson, Kevin A; Heppell, Selina S


    With the ongoing crisis of biodiversity loss and limited resources for conservation, the concept of biodiversity hotspots has been useful in determining conservation priority areas. However, there has been limited research into how temporal variability in biodiversity may influence conservation area prioritization. To address this information gap, we present an approach to evaluate the temporal consistency of biodiversity hotspots in large marine ecosystems. Using a large scale, public monitoring dataset collected over an eight year period off the US Pacific Coast, we developed a methodological approach for avoiding biases associated with hotspot delineation. We aggregated benthic fish species data from research trawls and calculated mean hotspot thresholds for fish species richness and Shannon's diversity indices over the eight year dataset. We used a spatial frequency distribution method to assign hotspot designations to the grid cells annually. We found no areas containing consistently high biodiversity through the entire study period based on the mean thresholds, and no grid cell was designated as a hotspot for greater than 50% of the time-series. To test if our approach was sensitive to sampling effort and the geographic extent of the survey, we followed a similar routine for the northern region of the survey area. Our finding of low consistency in benthic fish biodiversity hotspots over time was upheld, regardless of biodiversity metric used, whether thresholds were calculated per year or across all years, or the spatial extent for which we calculated thresholds and identified hotspots. Our results suggest that static measures of benthic fish biodiversity off the US West Coast are insufficient for identification of hotspots and that long-term data are required to appropriately identify patterns of high temporal variability in biodiversity for these highly mobile taxa. Given that ecological communities are responding to a changing climate and other

  12. Nuclear energy release from fragmentation

    Li, Cheng; Tsang, M B; Zhang, Feng-Shou


    Nuclear energy released by splitting Uranium and Thorium isotopes into two, three, four, up to eight fragments with nearly equal size are studied. We found that the energy released come from equally splitting the $^{235,238}$U and $^{230,232}$Th nuclei into to three fragments is largest. The statistical multifragmentation model is employed to calculate the probability of different breakup channels for the excited nuclei. Weighing the the probability distributions of fragments multiplicity at different excitation energies for the $^{238}$U nucleus, we found that an excitation energy between 1.2 and 2 MeV/u is optimal for the $^{235}$U, $^{238}$U, $^{230}$Th and $^{232}$Th nuclei to release nuclear energy of about 0.7-0.75 MeV/u.

  13. Reduction of calcium release site models via fast/slow analysis and iterative aggregation/disaggregation.

    Hao, Yan; Kemper, Peter; Smith, Gregory D


    Mathematical models of calcium release sites derived from Markov chain models of intracellular calcium channels exhibit collective gating reminiscent of the experimentally observed phenomenon of calcium puffs and sparks. Such models often take the form of stochastic automata networks in which the transition probabilities of each channel depend on the local calcium concentration and thus the state of the other channels. In order to overcome the state-space explosion that occurs in such compositionally defined calcium release site models, we have implemented several automated procedures for model reduction using fast/slow analysis. After categorizing rate constants in the single channel model as either fast or slow, groups of states in the expanded release site model that are connected by fast transitions are lumped, and transition rates between reduced states are chosen consistent with the conditional probability distribution among states within each group. For small problems these conditional probability distributions can be numerically calculated from the full model without approximation. For large problems the conditional probability distributions can be approximated without the construction of the full model by assuming rapid mixing of states connected by fast transitions. Alternatively, iterative aggregation/disaggregation may be employed to obtain reduced calcium release site models in a memory-efficient fashion. Benchmarking of several different iterative aggregation/disaggregation-based fast/slow reduction schemes establishes the effectiveness of automated calcium release site reduction utilizing the Koury-McAllister-Stewart method.

  14. Pigeon navigation: exposure to environmental odours prior to release is sufficient for homeward orientation, but not for homing.

    Gagliardo, Anna; Pollonara, Enrica; Wikelski, Martin


    The role of environmental olfactory information in pigeon navigation has been extensively studied by analysing vanishing bearing distributions and homing performances of homing pigeons subjected to manipulation of their olfactory perception and/or the olfactory information they were exposed to during transportation and at the release site. However, their behaviour during the homing flight remains undocumented. In this experiment we report the analysis of tracks of birds made anosmic at the release site by washing their olfactory mucosa with zinc sulfate. We thus can assess the role of local odours at the release site as well as the role of environmental odours perceived on the way, far from the release site. We observed that pigeons transported and kept at the release site in purified air and made anosmic at the release site were unable to orient towards home and were impaired at homing. By contrast, pigeons allowed to smell environmental odours during transportation and at the release site, although made anosmic prior to release, displayed unimpaired homeward orientation, but nevertheless showed impaired homing performance. These results are consistent with the view that local odours at the release site are critical for determining the direction of displacement (olfactory map) and suggest that pigeons consult the olfactory map also during their homing flight in order to be able to find their way home.

  15. Dynamic Data-Driven Event Reconstruction for Atmospheric Releases

    Kosovic, B; Belles, R; Chow, F K; Monache, L D; Dyer, K; Glascoe, L; Hanley, W; Johannesson, G; Larsen, S; Loosmore, G; Lundquist, J K; Mirin, A; Neuman, S; Nitao, J; Serban, R; Sugiyama, G; Aines, R


    Accidental or terrorist releases of hazardous materials into the atmosphere can impact large populations and cause significant loss of life or property damage. Plume predictions have been shown to be extremely valuable in guiding an effective and timely response. The two greatest sources of uncertainty in the prediction of the consequences of hazardous atmospheric releases result from poorly characterized source terms and lack of knowledge about the state of the atmosphere as reflected in the available meteorological data. In this report, we discuss the development of a new event reconstruction methodology that provides probabilistic source term estimates from field measurement data for both accidental and clandestine releases. Accurate plume dispersion prediction requires the following questions to be answered: What was released? When was it released? How much material was released? Where was it released? We have developed a dynamic data-driven event reconstruction capability which couples data and predictive models through Bayesian inference to obtain a solution to this inverse problem. The solution consists of a probability distribution of unknown source term parameters. For consequence assessment, we then use this probability distribution to construct a ''''composite'' forward plume prediction which accounts for the uncertainties in the source term. Since in most cases of practical significance it is impossible to find a closed form solution, Bayesian inference is accomplished by utilizing stochastic sampling methods. This approach takes into consideration both measurement and forward model errors and thus incorporates all the sources of uncertainty in the solution to the inverse problem. Stochastic sampling methods have the additional advantage of being suitable for problems characterized by a non-Gaussian distribution of source term parameters and for cases in which the underlying dynamical system is non-linear. We initially

  16. Evaluation of glibenclamide microspheres for sustained release

    Kambham Venkateswarlu


    Full Text Available Context: Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailability and patient compliance. Earlier studies reported on glibenclamide (GBCM were not clear and hence, the step has been taken to explore the sustained release drug delivery system of GBCM. Aims: To evaluate the sustained release microspheres obtained of GBCM. Methods: Microspheres were prepared by ionic gelation method using the polymers like Eudragit RS 100 and xanthan gum. Polymers can sustain the drug release from microspheres. The prepared microspheres were subjected to micromeritic studies like Carr’s index, Hausner’s ratio and angle of repose. Results: Micromeritic studies confirmed that the microspheres possessing acceptable flow properties. It was observed from the in vitro release studies, formulations F8 and F9 showed sustained drug release for desired time of 12 h and when compared to F9, formulation F8 showed maximum drug release for 12 h. Conclusions: Results confirmed the formulation F8 consist of the polymers such as Eudragit RS 100 about 150 mg and xanthan gum about 100 mg showed desired sustained release of 12 h with 96.07% and kinetic studies confirmed that the release from microspheres followed non-Fickian diffusion mechanism. Due to its sustained release property, it could enhance the bioavailability of drug thereby improves the patient compliance and expect better treatment than conventional dosage forms.

  17. Toxics Release Inventory (TRI)

    U.S. Environmental Protection Agency — The Toxics Release Inventory (TRI) is a dataset compiled by the U.S. Environmental Protection Agency (EPA). It contains information on the release and waste...

  18. Intelligent Distributed Systems


    AFRL-AFOSR-VA-TR-2016-0006 Intelligent Distributed Systems A Stephen Morse YALE UNIV NEW HAVEN CT Final Report 10/23/2015 DISTRIBUTION A...and D. Fullmer. A distributed algorithm for efficiently solving linear equations and its applications. System and Control Letters, 2015. submitted... Distribution approved for public release. AF Office Of Scientific Research (AFOSR)/ RTA2 Arlington, Virginia 22203 Air Force Research Laboratory Air Force

  19. Evaluating the hydrological consistency of evaporation products

    López, Oliver


    Advances in space-based observations have provided the capacity to develop regional- to global-scale estimates of evaporation, offering insights into this key component of the hydrological cycle. However, the evaluation of large-scale evaporation retrievals is not a straightforward task. While a number of studies have intercompared a range of these evaporation products by examining the variance amongst them, or by comparison of pixel-scale retrievals against ground-based observations, there is a need to explore more appropriate techniques to comprehensively evaluate remote-sensing-based estimates. One possible approach is to establish the level of product agreement between related hydrological components: for instance, how well do evaporation patterns and response match with precipitation or water storage changes? To assess the suitability of this "consistency"-based approach for evaluating evaporation products, we focused our investigation on four globally distributed basins in arid and semi-arid environments, comprising the Colorado River basin, Niger River basin, Aral Sea basin, and Lake Eyre basin. In an effort to assess retrieval quality, three satellite-based global evaporation products based on different methodologies and input data, including CSIRO-PML, the MODIS Global Evapotranspiration product (MOD16), and Global Land Evaporation: the Amsterdam Methodology (GLEAM), were evaluated against rainfall data from the Global Precipitation Climatology Project (GPCP) along with Gravity Recovery and Climate Experiment (GRACE) water storage anomalies. To ensure a fair comparison, we evaluated consistency using a degree correlation approach after transforming both evaporation and precipitation data into spherical harmonics. Overall we found no persistent hydrological consistency in these dryland environments. Indeed, the degree correlation showed oscillating values between periods of low and high water storage changes, with a phase difference of about 2–3 months

  20. Consistent effects of a major QTL for thermal resistance in field-released Drosophila melanogaster

    Loeschcke, Volker; Kristensen, Torsten Nygård; Norry, Fabian M


    Molecular genetic markers can be used to identify quantitative trait loci (QTL) for thermal resistance and this has allowed characterization of a major QTL for knockdown resistance to high temperature in Drosophila melanogaster. The QTL showed trade-off associations with cold resistance under...

  1. CERN Press Release: CERN experiments observe particle consistent with long-sought Higgs boson


    Geneva, 4 July 2012. At a seminar held at CERN today as a curtain raiser to the year’s major particle physics conference, ICHEP2012 in Melbourne, the ATLAS and CMS experiments presented their latest preliminary results in the search for the long sought Higgs particle. Both experiments observe a new particle in the mass region around 125-126 GeV.   CERN physicists await the start of the Higgs seminar. “We observe in our data clear signs of a new particle, at the level of 5 sigma, in the mass region around 126 GeV. The outstanding performance of the LHC and ATLAS and the huge efforts of many people have brought us to this exciting stage,” said ATLAS experiment spokesperson Fabiola Gianotti, “but a little more time is needed to prepare these results for publication.” "The results are preliminary but the 5 sigma signal at around 125 GeV we’re seeing is dramatic. This is indeed a new particle. We know it must be a boson and it&...


    Michelson, C.


    An electromagnetic release mechanism is offered that may be used, for example, for supporting a safety rod for a nuclear reactor. The release mechanism is designed to have a large excess holding force and a rapid, uniform, and dependable release. The fast release is accomplished by providing the electromagnet with slotttd polts separated by an insulating potting resin, and by constructing the poles with a ferro-nickel alloy. The combination of these two features materially reduces the eddy current power density whenever the magnetic field changes during a release operation. In addition to these features, the design of the armature is such as to provide ready entrance of fluid into any void that might tend to form during release of the armature. This also improves the release time for the mechanism. The large holding force for the mechanism is accomplished by providing a small, selected, uniform air gap between the inner pole piece and the armature.


    任继鹏; 张逸; 钱诚; 何骞; 相秀娟; 郭景恒


    利用华南和西南森林小流域的长期观测结果,综合分析了土壤酸化过程中铝的形态分布与活化机理.结果显示,土壤水中单体铝(Ala)在10—400μmo·lL-1之间,其在不同流域的差异与土壤酸化密切相关.无机铝(Ali)是土壤水中单体铝的主要形态,有机铝(Alo)比例不足20%.在酸度高的土壤中Al3+是无机铝的主要形态,在酸度低的土壤中无机铝以羟基结合铝(HBA)为主.有机键合铝(Alcu、Alp)和无定型硅酸盐矿物铝(Alox)含量随土壤pH值降低而显著下降,是土壤水中铝的重要来源.土壤酸化过程中可交换铝(A%Fractions distribution and release mechanism of aluminum in acidic forest soils were investigated based on the long-term monitoring at 6 forest catchments,southern China.The results showed that monomeric aluminium(Ala) in soil water ranged from 10 to 400 m mol·L-1,mainly due to the variations in soil acidity.The dominant fraction of Ala in the soil water was inorganic aluminum(Ali),while organic fractions(Alo) were usually less than 20%.Al3+ was the main fraction in inorganic aluminum(Ali) for soils with high acidity,while HBA was the main inorganic faction for soils with low acidity.Both organically(Alcu,Alp) and inorganically bonded aluminium(Alox) were important sources of aluminum in soil water,while exchangeable aluminum(Alex) significantly(p0.01) increased with the decrease of soil pH.The activity Al3+(pAl) and the pH correlated significantly(p0.01) in soil water,but did not meet the gibbsite model.Both exchangeable aluminum and organically bound aluminum model can be more satisfactorily used to interpret Al3+ activity variations based on linear regression.However,regression results of such models containing soil parameters,achieved in specific sites,should not be extended to regional scale due to the substantial regional variations in used soil parameters.

  4. Consistent Design of Dependable Control Systems

    Blanke, M.


    Design of fault handling in control systems is discussed, and a method for consistent design is presented.......Design of fault handling in control systems is discussed, and a method for consistent design is presented....

  5. A novel fluoride anion modified gelatin nanogel system for ultrasound-triggered drug release.

    Wu, Daocheng; Wan, Mingxi


    Controlled drug release, especially tumor-targeted drug release, remains a great challenge. Here, we prepare a novel fluoride anion-modified gelatin nanogel system and investigate its characteristics of ultrasound-triggered drug release. Adriamycin gelatin nanogel modified with fluoride anion (ADM-GNMF) was prepared by a modified co-precipitation method with fluoride anion and sodium sulfate. The loading and encapsulation efficiency of the anti-neoplastic agent adriamycin (ADM) were measured by high performance liquid chromatography (HPLC). The size and shape of ADM-GNMF were determined by electron microscopy and photo-correlation spectroscopy. The size distribution and drug release efficiency of ADM-GNMF, before and after sonication, were measured by two designed measuring devices that consisted of either a submicron particle size analyzer and an ultrasound generator as well as an ultrasound generator, automatic sampler, and HPLC. The ADM-GNMF was stable in solution with an average diameter of 46+/-12 nm; the encapsulation and loading efficiency of adriamycin were 87.2% and 6.38%, respectively. The ultrasound-triggered drug release and size change were most efficient at a frequency of 20 kHz, power density of 0.4w/cm2, and a 1~2 min duration. Under this ultrasound-triggered condition, 51.5% of drug in ADM-GNMF was released within 1~2 min, while the size of ADM-GNMF changed from 46 +/- 12 nm to 1212 +/- 35 nm within 1~2 min of sonication and restored to its previous size in 2~3 min after the ultrasound stopped. In contrast, 8.2% of drug in ADM-GNMF was released within 2~3 min without sonication, and only negligible size changes were found. The ADM-GNMF system efficiently released the encompassed drug in response to ultrasound, offering a novel and promising controlled drug release system for targeted therapy for cancer or other diseases.

  6. Self-consistent dynamics of wall slip

    Dubbeldam, J.L.A.; Molenaar, J.


    A simple molecular model is studied to explain wall slip in a polymer melt. We consider a tube model for tethered chains in which the most important relaxation mechanisms: convective constraint release and chain stretching (retraction), are incorporated. Furthermore, we take the interactions between

  7. Release the Body, Release the Mind.

    Stoner, Martha Goff


    A college English teacher describes the anxiety and resentment of students during in-class writing assignments and the successful classroom use of meditation and body movement. Movement seemed to relax the students, change their attitudes, and release their creative impulses to write. Implications related to the body-mind connection are pondered.…

  8. MDCC: Multi-Data Center Consistency

    Kraska, Tim; Franklin, Michael J; Madden, Samuel


    Replicating data across multiple data centers not only allows moving the data closer to the user and, thus, reduces latency for applications, but also increases the availability in the event of a data center failure. Therefore, it is not surprising that companies like Google, Yahoo, and Netflix already replicate user data across geographically different regions. However, replication across data centers is expensive. Inter-data center network delays are in the hundreds of milliseconds and vary significantly. Synchronous wide-area replication is therefore considered to be unfeasible with strong consistency and current solutions either settle for asynchronous replication which implies the risk of losing data in the event of failures, restrict consistency to small partitions, or give up consistency entirely. With MDCC (Multi-Data Center Consistency), we describe the first optimistic commit protocol, that does not require a master or partitioning, and is strongly consistent at a cost similar to eventually consiste...

  9. A dual-consistency cache coherence protocol

    Ros, Alberto; Jimborean, Alexandra


    Weak memory consistency models can maximize system performance by enabling hardware and compiler optimizations, but increase programming complexity since they do not match programmers’ intuition. The design of an efficient system with an intuitive memory model is an open challenge. This paper proposes SPEL, a dual-consistency cache coherence protocol which simultaneously guarantees the strongest memory consistency model provided by the hardware and yields improvements in both performance and ...

  10. A new approach to hull consistency

    Kolev Lubomir


    Full Text Available Hull consistency is a known technique to improve the efficiency of iterative interval methods for solving nonlinear systems describing steady-states in various circuits. Presently, hull consistency is checked in a scalar manner, i.e. successively for each equation of the nonlinear system with respect to a single variable. In the present poster, a new more general approach to implementing hull consistency is suggested which consists in treating simultaneously several equations with respect to the same number of variables.

  11. Consistency of Trend Break Point Estimator with Underspecified Break Number

    Jingjing Yang


    Full Text Available This paper discusses the consistency of trend break point estimators when the number of breaks is underspecified. The consistency of break point estimators in a simple location model with level shifts has been well documented by researchers under various settings, including extensions such as allowing a time trend in the model. Despite the consistency of break point estimators of level shifts, there are few papers on the consistency of trend shift break point estimators in the presence of an underspecified break number. The simulation study and asymptotic analysis in this paper show that the trend shift break point estimator does not converge to the true break points when the break number is underspecified. In the case of two trend shifts, the inconsistency problem worsens if the magnitudes of the breaks are similar and the breaks are either both positive or both negative. The limiting distribution for the trend break point estimator is developed and closely approximates the finite sample performance.

  12. Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies.

    Lee, Teng Huar; Wang, Jianjun; Wang, Chi-Hwa


    Composite double-walled microspheres with biodegradable poly(L-lactic acid) (PLLA) shells and poly(D,L-lactic-co-glycolic acid) (PLGA) cores were fabricated with highly water-soluble etanidazole entrapped within the core as solid crystals. This paper discusses the characterization, in vitro release and the effects of irradiation on this class of microsphere. Through the variation of polymer mass ratios, predictable shell and core dimensions could be fabricated and used to regulate the release rates. A direct and simple method was devised to determine the composition of the shell and core polymer based on the different solubilities of the polymer pair in ethyl acetate. A distribution theory based on solubility parameter explains why highly hydrophilic etanidazole has the tendency to be distributed consistently to the more hydrophilic polymer. Release profiles for normal double-walled samples have about 80% of drug released over 10 days after the initial time lag, while for irradiated double-walled samples, the sustained release lasted for more than 3 weeks. Although sustained release was short of the desired 6-8 weeks required for therapy, a low initial burst of less than 5% and time lags that can be manipulated, allows for administration of these microspheres together with traditional ones to generate pulsatile or new type of releases. The effects of irradiation were also investigated to determine the suitability of these double-walled microspheres as delivery devices to be used in conjunction with radiotherapy. Typical therapeutic dosage of 50 Gy was found to be too mild to have noticeable effects on the polymer and its release profiles, while, sterilization dosages of 25 kGy, lowered the glass transition temperatures and crystalline melting point, indirectly indicating a decrease in molecular weight. This accelerated degradation of the polymer, hence releasing the drug.

  13. Student Effort, Consistency, and Online Performance

    Patron, Hilde; Lopez, Salvador


    This paper examines how student effort, consistency, motivation, and marginal learning, influence student grades in an online course. We use data from eleven Microeconomics courses taught online for a total of 212 students. Our findings show that consistency, or less time variation, is a statistically significant explanatory variable, whereas…

  14. Consistent truncations with massive modes and holography

    Cassani, Davide; Faedo, Anton F


    We review the basic features of some recently found consistent Kaluza-Klein truncations including massive modes. We emphasize the general ideas underlying the reduction procedure, then we focus on type IIB supergravity on 5-dimensional manifolds admitting a Sasaki-Einstein structure, which leads to half-maximal gauged supergravity in five dimensions. Finally, we comment on the holographic picture of consistency.


    Levedahl, J. William; Reed, Albert J.; Clark, J. Stephen


    Two aggregation schemes for food demand systems are tested for consistency with the Generalized Composite Commodity Theorem (GCCT). One scheme is based on the standard CES classification of food expenditures. The second scheme is based on the Food Guide Pyramid. Evidence is found that both schemes are consistent with the GCCT.

  16. A Framework of Memory Consistency Models

    胡伟武; 施巍松; 等


    Previous descriptions of memory consistency models in shared-memory multiprocessor systems are mainly expressed as constraints on the memory access event ordering and hence are hardware-centric.This paper presents a framework of memory consistency models which describes the memory consistency model on the behavior level.Based on the understanding that the behavior of an execution is determined by the execution order of conflicting accesses,a memory consistency model is defined as an interprocessor synchronization mechanism which orders the execution of operations from different processors.Synchronization order of an execution under certain consistency model is also defined.The synchronization order,together with the program order determines the behavior of an execution.This paper also presents criteria for correct program and correct implementation of consistency models.Regarding an implementation of a consistency model as certain memory event ordering constraints,this paper provides a method to prove the correctness of consistency model implementations,and the correctness of the lock-based cache coherence protocol is proved with this method.

  17. Sticky continuous processes have consistent price systems

    Bender, Christian; Pakkanen, Mikko; Sayit, Hasanjan

    Under proportional transaction costs, a price process is said to have a consistent price system, if there is a semimartingale with an equivalent martingale measure that evolves within the bid-ask spread. We show that a continuous, multi-asset price process has a consistent price system, under arb...

  18. Testing the visual consistency of web sites

    Geest, van der Thea; Loorbach, Nicole


    Consistency in the visual appearance of Web pages is often checked by experts, such as designers or reviewers. This article reports a card sort study conducted to determine whether users rather than experts could distinguish visual (in-)consistency in Web elements and pages. The users proved to agre

  19. Putting Consistent Theories Together in Institutions



    The problem of putting consistent theories together in institutions is discussed.A general necessary condition for consistency of the resulting theory is carried out,and some sufficient conditions are given for diagrams of theories in which shapes are tree bundles or directed graphs.Moreover,some transformations from complicated cases to simple ones are established.

  20. Modeling and Testing Legacy Data Consistency Requirements

    Nytun, J. P.; Jensen, Christian Søndergaard


    An increasing number of data sources are available on the Internet, many of which offer semantically overlapping data, but based on different schemas, or models. While it is often of interest to integrate such data sources, the lack of consistency among them makes this integration difficult....... This paper addresses the need for new techniques that enable the modeling and consistency checking for legacy data sources. Specifically, the paper contributes to the development of a framework that enables consistency testing of data coming from different types of data sources. The vehicle is UML and its...... accompanying XMI. The paper presents techniques for modeling consistency requirements using OCL and other UML modeling elements: it studies how models that describe the required consistencies among instances of legacy models can be designed in standard UML tools that support XMI. The paper also considers...

  1. The cluster bootstrap consistency in generalized estimating equations

    Cheng, Guang


    The cluster bootstrap resamples clusters or subjects instead of individual observations in order to preserve the dependence within each cluster or subject. In this paper, we provide a theoretical justification of using the cluster bootstrap for the inferences of the generalized estimating equations (GEE) for clustered/longitudinal data. Under the general exchangeable bootstrap weights, we show that the cluster bootstrap yields a consistent approximation of the distribution of the regression estimate, and a consistent approximation of the confidence sets. We also show that a computationally more efficient one-step version of the cluster bootstrap provides asymptotically equivalent inference. © 2012.


    ANDREWS, MALCOLM J. [Los Alamos National Laboratory; BERCHANE, NADER S. [Los Alamos National Laboratory; CARSON, KENNETH H. [Los Alamos National Laboratory; RICE-FICHT, ALLISON C. [Los Alamos National Laboratory


    Piroxicam containing PLG microspheres having different size distributions were fabricated, and in vitro release kinetics were determined for each preparation. Based on the experimental results, a suitable mathematical theory has been developed that incorporates the effect of microsphere size distribution and polymer degradation on drug release. We show from in vitro release experiments that microsphere size has a significant effect on drug release rate. The initial release rate decreased with an increase in microsphere size. In addition, the release profile changed from first order to concave-upward (sigmoidal) as the system size was increased. The mathematical model gave a good fit to the experimental release data.

  3. A minimal model of self-consistent partial synchrony

    Clusella, Pau; Politi, Antonio; Rosenblum, Michael


    We show that self-consistent partial synchrony in globally coupled oscillatory ensembles is a general phenomenon. We analyze in detail appearance and stability properties of this state in possibly the simplest setup of a biharmonic Kuramoto-Daido phase model as well as demonstrate the effect in limit-cycle relaxational Rayleigh oscillators. Such a regime extends the notion of splay state from a uniform distribution of phases to an oscillating one. Suitable collective observables such as the Kuramoto order parameter allow detecting the presence of an inhomogeneous distribution. The characteristic and most peculiar property of self-consistent partial synchrony is the difference between the frequency of single units and that of the macroscopic field.

  4. Intracellular drug release nanosystems

    Fenghua Meng


    Full Text Available In order to elicit therapeutic effects, many drugs including small molecule anticancer drugs, proteins, siRNA, and DNA have to be delivered and released into the specific cellular compartments typically the cytoplasm or nucleus of target cells. Intracellular environment-responsive nanosystems that exhibit good extracellular stability while rapidly releasing drugs inside cancer cells have been actively pursued for effective cancer therapy. Here, we highlight novel designs of smart nanosystems that release drugs in response to an intracellular biological signal of cancer cells such as acidic pH in endo/lysosomal compartments, enzymes in lysosomes, and redox potential in cytoplasm and the cell nucleus.

  5. On the Initial State and Consistency Relations

    Berezhiani, Lasha


    We study the effect of the initial state on the consistency conditions for adiabatic perturbations. In order to be consistent with the constraints of General Relativity, the initial state must be diffeomorphism invariant. As a result, we show that initial wavefunctional/density matrix has to satisfy a Slavnov-Taylor identity similar to that of the action. We then investigate the precise ways in which modified initial states can lead to violations of the consistency relations. We find two independent sources of violations: i) the state can include initial non-Gaussianities; ii) even if the initial state is Gaussian, such as a Bogoliubov state, the modified 2-point function can modify the q->0 analyticity properties of the vertex functional and result in violations of the consistency relations.

  6. On the initial state and consistency relations

    Berezhiani, Lasha; Khoury, Justin, E-mail:, E-mail: [Center for Particle Cosmology, Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104 (United States)


    We study the effect of the initial state on the consistency conditions for adiabatic perturbations. In order to be consistent with the constraints of General Relativity, the initial state must be diffeomorphism invariant. As a result, we show that initial wavefunctional/density matrix has to satisfy a Slavnov-Taylor identity similar to that of the action. We then investigate the precise ways in which modified initial states can lead to violations of the consistency relations. We find two independent sources of violations: i) the state can include initial non-Gaussianities; ii) even if the initial state is Gaussian, such as a Bogoliubov state, the modified 2-point function can modify the q-vector → 0 analyticity properties of the vertex functional and result in violations of the consistency relations.

  7. Self-Consistent Asset Pricing Models

    Malevergne, Y


    We discuss the foundations of factor or regression models in the light of the self-consistency condition that the market portfolio (and more generally the risk factors) is (are) constituted of the assets whose returns it is (they are) supposed to explain. As already reported in several articles, self-consistency implies correlations between the return disturbances. As a consequence, the alpha's and beta's of the factor model are unobservable. Self-consistency leads to renormalized beta's with zero effective alpha's, which are observable with standard OLS regressions. Analytical derivations and numerical simulations show that, for arbitrary choices of the proxy which are different from the true market portfolio, a modified linear regression holds with a non-zero value $\\alpha_i$ at the origin between an asset $i$'s return and the proxy's return. Self-consistency also introduces ``orthogonality'' and ``normality'' conditions linking the beta's, alpha's (as well as the residuals) and the weights of the proxy por...

  8. Quasiparticle self-consistent GW theory.

    van Schilfgaarde, M; Kotani, Takao; Faleev, S


    In past decades the scientific community has been looking for a reliable first-principles method to predict the electronic structure of solids with high accuracy. Here we present an approach which we call the quasiparticle self-consistent approximation. It is based on a kind of self-consistent perturbation theory, where the self-consistency is constructed to minimize the perturbation. We apply it to selections from different classes of materials, including alkali metals, semiconductors, wide band gap insulators, transition metals, transition metal oxides, magnetic insulators, and rare earth compounds. Apart from some mild exceptions, the properties are very well described, particularly in weakly correlated cases. Self-consistency dramatically improves agreement with experiment, and is sometimes essential. Discrepancies with experiment are systematic, and can be explained in terms of approximations made.

  9. Consistency in the World Wide Web

    Thomsen, Jakob Grauenkjær

    Tim Berners-Lee envisioned that computers will behave as agents of humans on the World Wide Web, where they will retrieve, extract, and interact with information from the World Wide Web. A step towards this vision is to make computers capable of extracting this information in a reliable...... and consistent way. In this dissertation we study steps towards this vision by showing techniques for the specication, the verication and the evaluation of the consistency of information in the World Wide Web. We show how to detect certain classes of errors in a specication of information, and we show how...... the World Wide Web, in order to help perform consistent evaluations of web extraction techniques. These contributions are steps towards having computers reliable and consistently extract information from the World Wide Web, which in turn are steps towards achieving Tim Berners-Lee's vision. ii...

  10. Consistency Relations for Large Field Inflation

    Chiba, Takeshi


    Consistency relations for chaotic inflation with a monomial potential and natural inflation and hilltop inflation are given which involve the scalar spectral index $n_s$, the tensor-to-scalar ratio $r$ and the running of the spectral index $\\alpha$. The measurement of $\\alpha$ with $O(10^{-3})$ and the improvement in the measurement of $n_s$ could discriminate monomial model from natural/hilltop inflation models. A consistency region for general large field models is also presented.

  11. Tablet splitting: Product quality assessment of metoprolol succinate extended release tablets.

    Zhao, Na; Zidan, Ahmed; Tawakkul, Mobin; Sayeed, Vilayat A; Khan, Mansoor


    Metoprolol succinate extended release tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. Despite the flexibility that controlled release pellets may offer, segregation is one of the challenges that commonly occur during tableting for such drug delivery system. Since all commercial metoprolol succinate extended release tablets are scored, they are deemed suitable for splitting. The present study was aimed at utilizing an innovative technology to determine the dose uniformity for split tablets. Four marketed drug products consisting of innovator and generics were evaluated for effect of splitting on weight, assay and content uniformity. Novel analytical tool such as near infrared (NIR) chemical imaging was used to visualize the distribution of metoprolol succinate and functional excipients on the surfaces of the marketed tablets. The non-homogeneous distribution of directly compressed metoprolol succinate beads on the surface of the tablets as well as the split intersection explained the large variation in the split tablets' weight and content uniformity results. The obtained results indicated the usefulness of NIR chemical imaging to determine the need for content uniformity studies for certain split tablets.

  12. Miniature Release Mechanism Project

    National Aeronautics and Space Administration — The objective is to design, build and functionally test a miniature release mechanism for CubeSats and other small satellites. The WFF 6U satellite structure will be...

  13. EPICS release 3.11 specific documentation -- EPICS release notes for 3.11



    EPICS release 3.11 is now ready for user testing. A person who wants to set up a simplified application environment to boot an IOC and create databases using R3.11 should follow the directions in Appendix B, page 27, of the EPICS Source/Release Control Manual, Sept. 20, 1993. The R3.11 EPICS path at ANL/APS is /net/phebos/epics/R3.11 so the command to get the new release is /net/phebos/epics/R3.11/Unix/share/bin/getrel /net/phebos/epics/R3.11. An existing R3.8 short form report can be copied to this new directory and used to create a database. ANL/APS is currently testing an Application Developers Source/Release control system. It is not yet ready for general distribution. Attached are the EPICS R3.11 release notes.

  14. Entropy-based consistent model driven architecture

    Niepostyn, Stanisław Jerzy


    A description of software architecture is a plan of the IT system construction, therefore any architecture gaps affect the overall success of an entire project. The definitions mostly describe software architecture as a set of views which are mutually unrelated, hence potentially inconsistent. Software architecture completeness is also often described in an ambiguous way. As a result most methods of IT systems building comprise many gaps and ambiguities, thus presenting obstacles for software building automation. In this article the consistency and completeness of software architecture are mathematically defined based on calculation of entropy of the architecture description. Following this approach, in this paper we also propose our method of automatic verification of consistency and completeness of the software architecture development method presented in our previous article as Consistent Model Driven Architecture (CMDA). The proposed FBS (Functionality-Behaviour-Structure) entropy-based metric applied in our CMDA approach enables IT architects to decide whether the modelling process is complete and consistent. With this metric, software architects could assess the readiness of undergoing modelling work for the start of IT system building. It even allows them to assess objectively whether the designed software architecture of the IT system could be implemented at all. The overall benefit of such an approach is that it facilitates the preparation of complete and consistent software architecture more effectively as well as it enables assessing and monitoring of the ongoing modelling development status. We demonstrate this with a few industry examples of IT system designs.

  15. Consistency and Derangements in Brane Tilings

    Hanany, Amihay; Ramgoolam, Sanjaye; Seong, Rak-Kyeong


    Brane tilings describe Lagrangians (vector multiplets, chiral multiplets, and the superpotential) of four dimensional $\\mathcal{N}=1$ supersymmetric gauge theories. These theories, written in terms of a bipartite graph on a torus, correspond to worldvolume theories on $N$ D$3$-branes probing a toric Calabi-Yau threefold singularity. A pair of permutations compactly encapsulates the data necessary to specify a brane tiling. We show that geometric consistency for brane tilings, which ensures that the corresponding quantum field theories are well behaved, imposes constraints on the pair of permutations, restricting certain products constructed from the pair to have no one-cycles. Permutations without one-cycles are known as derangements. We illustrate this formulation of consistency with known brane tilings. Counting formulas for consistent brane tilings with an arbitrary number of chiral bifundamental fields are written down in terms of delta functions over symmetric groups.

  16. Quantifying the consistency of scientific databases

    Šubelj, Lovro; Boshkoska, Biljana Mileva; Kastrin, Andrej; Levnajić, Zoran


    Science is a social process with far-reaching impact on our modern society. In the recent years, for the first time we are able to scientifically study the science itself. This is enabled by massive amounts of data on scientific publications that is increasingly becoming available. The data is contained in several databases such as Web of Science or PubMed, maintained by various public and private entities. Unfortunately, these databases are not always consistent, which considerably hinders this study. Relying on the powerful framework of complex networks, we conduct a systematic analysis of the consistency among six major scientific databases. We found that identifying a single "best" database is far from easy. Nevertheless, our results indicate appreciable differences in mutual consistency of different databases, which we interpret as recipes for future bibliometric studies.

  17. Self-consistent Green's function approaches

    Barbieri, Carlo


    We present the fundamental techniques and working equations of many-body Green's function theory for calculating ground state properties and the spectral strength. Green's function methods closely relate to other polynomial scaling approaches discussed in chapters~8 and ~10. However, here we aim directly at a global view of the many-fermion structure. We derive the working equations for calculating many-body propagators, using both the Algebraic Diagrammatic Construction technique and the self-consistent formalism at finite temperature. Their implementation is discussed, as well as the the inclusion of three-nucleon interactions. The self-consistency feature is essential to guarantee thermodynamic consistency. The paring and neutron matter models introduced in previous chapters are solved and compared with the other methods in this book.

  18. Personalized recommendation based on unbiased consistence

    Zhu, Xuzhen; Tian, Hui; Zhang, Ping; Hu, Zheng; Zhou, Tao


    Recently, in physical dynamics, mass-diffusion-based recommendation algorithms on bipartite network provide an efficient solution by automatically pushing possible relevant items to users according to their past preferences. However, traditional mass-diffusion-based algorithms just focus on unidirectional mass diffusion from objects having been collected to those which should be recommended, resulting in a biased causal similarity estimation and not-so-good performance. In this letter, we argue that in many cases, a user's interests are stable, and thus bidirectional mass diffusion abilities, no matter originated from objects having been collected or from those which should be recommended, should be consistently powerful, showing unbiased consistence. We further propose a consistence-based mass diffusion algorithm via bidirectional diffusion against biased causality, outperforming the state-of-the-art recommendation algorithms in disparate real data sets, including Netflix, MovieLens, Amazon and Rate Your Music.

  19. A Revisit to Probability - Possibility Consistency Principles

    Mamoni Dhar


    Full Text Available In this article, our main intention is to highlight the fact that the probable links between probability and possibility which were established by different authors at different point of time on the basis of some well known consistency principles cannot provide the desired result. That is why the paper discussed some prominent works for transformations between probability and possibility and finally aimed to suggest a new principle because none of the existing principles because none of them found the unique transformation. The new consistency principle which is suggested hereby would in turn replace all others that exist in the literature references by providing a reliable estimate of consistency between the two.Furthermore some properties of entropy of fuzzy numbers are also presented in this article.

  20. Consistent matter couplings for Plebanski gravity

    Tennie, Felix


    We develop a scheme for the minimal coupling of all standard types of tensor and spinor field matter to Plebanski gravity. This theory is a geometric reformulation of vacuum general relativity in terms of two-form frames and connection one-forms, and provides a covariant basis for various quantization approaches. Using the spinor formalism we prove the consistency of the newly proposed matter coupling by demonstrating the full equivalence of Plebanski gravity plus matter to Einstein--Cartan gravity. As a byproduct we also show the consistency of some previous suggestions for matter actions.

  1. Consistent matter couplings for Plebanski gravity

    Tennie, Felix; Wohlfarth, Mattias N. R.


    We develop a scheme for the minimal coupling of all standard types of tensor and spinor field matter to Plebanski gravity. This theory is a geometric reformulation of vacuum general relativity in terms of two-form frames and connection one-forms, and provides a covariant basis for various quantization approaches. Using the spinor formalism we prove the consistency of the newly proposed matter coupling by demonstrating the full equivalence of Plebanski gravity plus matter to Einstein-Cartan gravity. As a by-product we also show the consistency of some previous suggestions for matter actions.


    Gang Chen


    Full Text Available Naturally occurring clay colloidal particles are heavily involved in sediment processes in the subsurface soil. Due to the import ance of these processes in the subsurface environment, the transport of clay colloidal particles has been studied in several disciplines, including soil sciences, petr ology, hydrology, etc. Specifically, in environmental engineering, clay colloid re lease and transport in the sediments have been extensively investigated, which are motiv ated by environmental concerns such as colloid-facilitated contaminant transport in groundwater and the subsurface soil. Clay colloid release is resulted from physical alteration of subsurface sediments. Despite the potential importance of clay colloid activiti es, the detailed mechanisms of release and transport of clay colloidal particles with in natural sediments are poorly understood. Pore medium structure, properties and flow dynamics, etc. are factors that affect clay colloid generation, mobilization, and subse quent transport. Possible mechanisms of clay colloid generation in the sediments in clude precipitation, erosion and mobilization by changes in pore water chemistry and clay colloid release depends on a balance of applied hydrodynamic and resisting adhesive torques and forces. The coupled role of pore water chemistry and fluid hydrodynamics thus play key roles in controlling clay colloid release and transport in the sediment s. This paper investigated clay colloidal particle release and transport, especially th e colloidal particle release mechanisms as well as the process modeling in the sediments. In this research, colloidal particle release from intact sediment columns with variable length was examined and colloidal particle release curves were simulated using an im plicit, finite-difference scheme. Colloidal particle release rate coefficient was found to be an exponential function of the sediment depth. The simulated results demonstrated that transport parameters were

  3. Consistency in multi-viewpoint architectural design

    Dijkman, R.M.; Dijkman, Remco Matthijs


    This thesis presents a framework that aids in preserving consistency in multi-viewpoint designs. In a multi-viewpoint design each stakeholder constructs his own design part. We call each stakeholder’s design part the view of that stakeholder. To construct his view, a stakeholder has a viewpoint.

  4. Consistency and stability of recombinant fermentations.

    Wiebe, M E; Builder, S E


    Production of proteins of consistent quality in heterologous, genetically-engineered expression systems is dependent upon identifying the manufacturing process parameters which have an impact on product structure, function, or purity, validating acceptable ranges for these variables, and performing the manufacturing process as specified. One of the factors which may affect product consistency is genetic instability of the primary product sequence, as well as instability of genes which code for proteins responsible for post-translational modification of the product. Approaches have been developed for mammalian expression systems to assure that product quality is not changing through mechanisms of genetic instability. Sensitive protein analytical methods, particularly peptide mapping, are used to evaluate product structure directly, and are more sensitive in detecting genetic instability than is direct genetic analysis by nucleotide sequencing of the recombinant gene or mRNA. These methods are being employed to demonstrate that the manufacturing process consistently yields a product of defined structure from cells cultured through the range of cell ages used in the manufacturing process and well beyond the maximum cell age defined for the process. The combination of well designed validation studies which demonstrate consistent product quality as a function of cell age, and rigorous quality control of every product lot by sensitive protein analytical methods provide the necessary assurance that product structure is not being altered through mechanisms of mutation and selection.

  5. Developing consistent time series landsat data products

    The Landsat series satellite has provided earth observation data record continuously since early 1970s. There are increasing demands on having a consistent time series of Landsat data products. In this presentation, I will summarize the work supported by the USGS Landsat Science Team project from 20...

  6. Developing consistent pronunciation models for phonemic variants

    Davel, M


    Full Text Available from a lexicon containing variants. In this paper we (the authors) address both these issues by creating ‘pseudo-phonemes’ associated with sets of ‘generation restriction rules’ to model those pronunciations that are consistently realised as two or more...

  7. On Consistency Maintenance In Service Discovery

    Sundramoorthy, V.; Hartel, Pieter H.; Scholten, Johan


    Communication and node failures degrade the ability of a service discovery protocol to ensure Users receive the correct service information when the service changes. We propose that service discovery protocols employ a set of recovery techniques to recover from failures and regain consistency. We

  8. On Consistency Maintenance In Service Discovery

    Sundramoorthy, V.; Hartel, Pieter H.; Scholten, Johan

    Communication and node failures degrade the ability of a service discovery protocol to ensure Users receive the correct service information when the service changes. We propose that service discovery protocols employ a set of recovery techniques to recover from failures and regain consistency. We

  9. Consistent feeding positions of great tit parents

    Lessells, C.M.; Poelman, E.H.; Mateman, A.C.; Cassey, P.


    When parent birds arrive at the nest to provision their young, their position on the nest rim may influence which chick or chicks are fed. As a result, the consistency of feeding positions of the individual parents, and the difference in position between the parents, may affect how equitably food is

  10. Computing Rooted and Unrooted Maximum Consistent Supertrees

    van Iersel, Leo


    A chief problem in phylogenetics and database theory is the computation of a maximum consistent tree from a set of rooted or unrooted trees. A standard input are triplets, rooted binary trees on three leaves, or quartets, unrooted binary trees on four leaves. We give exact algorithms constructing rooted and unrooted maximum consistent supertrees in time O(2^n n^5 m^2 log(m)) for a set of m triplets (quartets), each one distinctly leaf-labeled by some subset of n labels. The algorithms extend to weighted triplets (quartets). We further present fast exact algorithms for constructing rooted and unrooted maximum consistent trees in polynomial space. Finally, for a set T of m rooted or unrooted trees with maximum degree D and distinctly leaf-labeled by some subset of a set L of n labels, we compute, in O(2^{mD} n^m m^5 n^6 log(m)) time, a tree distinctly leaf-labeled by a maximum-size subset X of L that all trees in T, when restricted to X, are consistent with.

  11. Addendum to "On the consistency of MPS"

    Souto-Iglesias, Antonio; González, Leo M; Cercos-Pita, Jose L


    The analogies between the Moving Particle Semi-implicit method (MPS) and Incompressible Smoothed Particle Hydrodynamics method (ISPH) are established in this note, as an extension of the MPS consistency analysis conducted in "Souto-Iglesias et al., Computer Physics Communications, 184(3), 2013."

  12. Proteolysis and consistency of Meshanger cheese

    Jong, de L.


    Proteolysis in Meshanger cheese, estimated by quantitative polyacrylamide gel electrophoresis is discussed. The conversion of α s1 -casein was proportional to rennet concentration in the cheese. Changes in consistency, after a maximum, were correlated to breakdown of

  13. On the existence of consistent price systems

    Bayraktar, Erhan; Pakkanen, Mikko S.; Sayit, Hasanjan


    We formulate a sufficient condition for the existence of a consistent price system (CPS), which is weaker than the conditional full support condition (CFS). We use the new condition to show the existence of CPSs for certain processes that fail to have the CFS property. In particular this condition...

  14. A self-consistent Maltsev pulse model

    Buneman, O.


    A self-consistent model for an electron pulse propagating through a plasma is presented. In this model, the charge imbalance between plasma ions, plasma electrons and pulse electrons creates the travelling potential well in which the pulse electrons are trapped.

  15. Consistent implementation of decisions in the brain.

    James A R Marshall

    Full Text Available Despite the complexity and variability of decision processes, motor responses are generally stereotypical and independent of decision difficulty. How is this consistency achieved? Through an engineering analogy we consider how and why a system should be designed to realise not only flexible decision-making, but also consistent decision implementation. We specifically consider neurobiologically-plausible accumulator models of decision-making, in which decisions are made when a decision threshold is reached. To trade-off between the speed and accuracy of the decision in these models, one can either adjust the thresholds themselves or, equivalently, fix the thresholds and adjust baseline activation. Here we review how this equivalence can be implemented in such models. We then argue that manipulating baseline activation is preferable as it realises consistent decision implementation by ensuring consistency of motor inputs, summarise empirical evidence in support of this hypothesis, and suggest that it could be a general principle of decision making and implementation. Our goal is therefore to review how neurobiologically-plausible models of decision-making can manipulate speed-accuracy trade-offs using different mechanisms, to consider which of these mechanisms has more desirable decision-implementation properties, and then review the relevant neuroscientific data on which mechanism brains actually use.

  16. Consistency in multi-viewpoint architectural design

    Dijkman, Remco Matthijs


    This thesis presents a framework that aids in preserving consistency in multi-viewpoint designs. In a multi-viewpoint design each stakeholder constructs his own design part. We call each stakeholder¿s design part the view of that stakeholder. To construct his view, a stakeholder has a viewpoint. Thi

  17. Properties and Update Semantics of Consistent Views


    8217 PR.OPERTIES AND UPDATE SEMANTICS OF CONSISTENT VIEWS G. Gottlob Institute for Applied Mathematics C.N.H.., G<•nova, Italy Compnt.<•r Sden... Gottlob G., Paolini P., Zicari R., "Proving Properties of Programs ou Database Views", Dipartiuwnto di Elcttronica, Politecnko di Milano (in

  18. Consistency Analysis of Network Traffic Repositories

    Lastdrager, Elmer; Pras, Aiko


    Traffic repositories with TCP/IP header information are very important for network analysis. Researchers often assume that such repositories reliably represent all traffic that has been flowing over the network; little thoughts are made regarding the consistency of these repositories. Still, for var

  19. Consistency of Network Traffic Repositories: An Overview

    Lastdrager, E.; Pras, A.


    Traffc repositories with TCP/IP header information are very important for network analysis. Researchers often assume that such repositories reliably represent all traffc that has been flowing over the network; little thoughts are made regarding the consistency of these repositories. Still, for vario

  20. Nonequilibrium thermodynamics of fuel cells: Heat release mechanisms and voltage

    Wilemski, G.


    Nonequilibrium thermodynamics is used to analyze the spatial distribution of heat release mechanisms occurring in fuel cells operating under load in nonisothermal steady states. Novel contributions to heat release in the bulk electrolyte are found which are analogous to Peltier and Thomson effects in metallic conductors. Expresions for the heat release at individual electrodes are presented. An equation for the voltage of these cells is also derived.

  1. Consistency and variability in functional localisers

    Duncan, Keith J.; Pattamadilok, Chotiga; Knierim, Iris; Devlin, Joseph T.


    A critical assumption underlying the use of functional localiser scans is that the voxels identified as the functional region-of-interest (fROI) are essentially the same as those activated by the main experimental manipulation. Intra-subject variability in the location of the fROI violates this assumption, reducing the sensitivity of the analysis and biasing the results. Here we investigated consistency and variability in fROIs in a set of 45 volunteers. They performed two functional localiser scans to identify word- and object-sensitive regions of ventral and lateral occipito-temporal cortex, respectively. In the main analyses, fROIs were defined as the category-selective voxels in each region and consistency was measured as the spatial overlap between scans. Consistency was greatest when minimally selective thresholds were used to define “active” voxels (p < 0.05 uncorrected), revealing that approximately 65% of the voxels were commonly activated by both scans. In contrast, highly selective thresholds (p < 10− 4 to 10− 6) yielded the lowest consistency values with less than 25% overlap of the voxels active in both scans. In other words, intra-subject variability was surprisingly high, with between one third and three quarters of the voxels in a given fROI not corresponding to those activated in the main task. This level of variability stands in striking contrast to the consistency seen in retinotopically-defined areas and has important implications for designing robust but efficient functional localiser scans. PMID:19289173

  2. Distribution and Action of Gonadotropin-releasing Hormone in the Female Reproductive System%促性腺激素释放激素在女性生殖系统的分布与作用

    高江曼; 于洋; 乔杰


    促性腺激素释放激素(gonadotropin releasing hormone,GnRH)是下丘脑分泌的十肽激素,对生殖调控具有重要意义.人体中存在2种亚型,即GnRH-Ⅰ和GnRH-Ⅱ,以及2种相应的受体GnRHR-Ⅰ和GnRHR-Ⅱ. GnRH除了通过垂体性腺轴控制女性的发育、生殖功能外,同时还以自分泌和旁分泌的方式作用于垂体外组织,如乳腺、胎盘、卵巢、子宫内膜等.GnRH或许可作为乳腺癌的一种有效治疗和预防恶化的方法.GnRH类似物已经用于治疗许多激素相关的疾病,尤其是与子宫相关的疾病,如子宫内膜增生、子宫内膜癌、子宫内膜异位症(EMs),可降低子宫颈癌的风险等.胎盘自身可生成GnRH或GnRH样多肽物质,离体的胎盘组织体外培养表明,GnRH可显著增加胎盘组织人绒毛膜促性腺激素(hCG)的释放.局部的GnRHs对维持卵巢功能具有重要的作用;卵巢GnRHs参与正常和异常生殖组织的内分泌调控.%Gonadotrophin-releasing hormone (GnRH),a neuropeptide with 10 amino-acid,plays a critical role in the regulation of reproduction.There are 2 genome types of GnRH in human,GnRH-Ⅰ and GnRH-Ⅱ,and 2 types of receptor,GnRHR-Ⅰ and GnRHR-Ⅱ.They regulate the reproduction and maturity through the hypothalamicpituitary-gonadal axis,and also have the effect on some extrapituitary compartments by autocrine and/or paracrine,including the breast,placenta,ovary and endometrium.GnRH may be a valuable effective method of treatment and prevention of deterioration for breast cancer.GnRH analogues have been used to treat many hormones related diseases,especially uterine diseases,such as endometrial hyperplasia,endometrial cancer and endometriosis (EMs),as well as reduce the risk of cervical cancer.Placenta can generate GnRH or GnRH-like peptides.Studies of placental tissue in vitro indicate that GnRH can significantly increase the release of human chorionic gonadotropin (hCG) from placenta tissue.Local GnRHs not only plays an

  3. Self-consistent stellar dynamical tori

    Ciotti, L; Londrillo, P


    We present preliminary results on a new family of distribution functions that are able to generate axisymmetric, truncated (i.e., finite size) stellar dynamical models characterized by toroidal shapes. The relevant distribution functions generalize those that are known to describe polytropic spheres, for which all the dynamical and structural properties of the system can be expressed in explicit form as elementary functions of the system gravitational potential. The model construction is then completed by a numerical study of the associated Poisson equation. We note that our axisymmetric models can also include the presence of an external gravitational field, such as that produced by a massive disk or by a central mass concentration (e.g., a supermassive black hole).

  4. The VIMOS Public Extragalactic Survey (VIPERS): First Release of spectra

    Franzetti, P; Guzzo, L; Marchetti, A; Scodeggio, M


    We release the spectra for the more than 57000 objects presented in the First VIPERS Data Release. For each object we distribute the observed, wavelength and flux calibrated spectrum, as well as cleaned spectra, where artifacts due to fringing are removed. We also provide the sky and noise spectrum and the 2D spectrum. Data can be downloaded from

  5. Checking Content Consistency of Integrated Web Documents

    Franz Weitl; Burkhard Freitag


    A conceptual framework for the specification and verification of constraints on the content and narrative structure of documents is proposed. As a specification formalism, CTLDL is defined, which is an extension of the temporal logic CTL by description logic concepts. In contrast to existing solutions this approach allows for the integration of ontologies to achieve interoperability and abstraction from implementation aspects of documents. This makes CTLDL specifically suitable for the integration of heterogeneous and distributed information resources in the semantic web.

  6. A fluoride release-adsorption-release system applied to fluoride-releasing restorative materials.

    Suljak, J P; Hatibovic-Kofman, S


    This investigation compared the initial fluoride release and release following refluoridation of three resin-modified glass-ionomer cements (Photac-Fil Applicap, Vitremer, and Fuji II LC) and a new polyacid-modified resin composite material (Dyract). After daily flouride release was measured for 8 days, specimens were refluoridated in 1,000-ppm solutions of fluoride ion for 10 minutes and fluoride release was measured for 5 days. Two further 5-day refluoridation-release periods were carried out. All materials released fluoride initially. Photac released the most; Dyract released the least. Initial release was greatest over the first few days. All materials released significantly more fluoride for 24 to 48 hours after refluoridation. Less fluoride was released with each successive refluoridation for the three glass-ionomer cements. The release from the Dyract compomer remained at a comparatively constant and significantly lower level following each refluoridation.

  7. Passive migration barriers using slow release oxygen compounds

    Norris, R.D. [Eckenfelder, Inc., Nashville, TN (United States); Johnson, J. [GRAM, Inc., Albuquerque, NM (United States); Odencrantz, J. [TRI-S Environmental Corp., Newport Beach, CA (United States)] [and others


    This paper describes passive barriers for controlling downgradient plume migration in contaminated aquifers. Numerous field studies using migration barriers to control benzene, toluene, ethylbenzene, and xylene (BTEX) plumes are briefly summarized. The barriers consist of a patented oxygen release compound placed in a row of wells transecting a BTEX plume. Oxygen is slowly released to the saturated zone, thus enhancing natural biodegradation. Migration is controlled by matching the oxygen release rate to the flux and oxygen demand of the dissolved contaminants.

  8. Consistency of accuracy assessment indices for soft classification: Simulation analysis

    Chen, Jin; Zhu, Xiaolin; Imura, Hidefumi; Chen, Xuehong

    Accuracy assessment plays a crucial role in the implementation of soft classification. Even though many indices of accuracy assessment for soft classification have been proposed, the consistencies among these indices are not clear, and the impact of sample size on these consistencies has not been investigated. This paper examines two kinds of indices: map-level indices, including root mean square error ( rmse), kappa, and overall accuracy ( oa) from the sub-pixel confusion matrix (SCM); and category-level indices, including crmse, user accuracy ( ua) and producer accuracy ( pa). A careful simulation was conducted to investigate the consistency of these indices and the effect of sample size. The major findings were as follows: (1) The map-level indices are highly consistent with each other, whereas the category-level indices are not. (2) The consistency among map-level and category-level indices becomes weaker when the sample size decreases. (3) The rmse is more affected by error distribution among classes than are kappa and oa. Based on these results, we recommend that rmse can be used for map-level accuracy due to its simplicity, although kappa and oa may be better alternatives when the sample size is limited because the two indices are affected less by the error distribution among classes. We also suggest that crmse should be provided when map users are not concerned about the error source, whereas ua and pa are more useful when the complete information about different errors is required. The results of this study will be of benefit to the development and application of soft classifiers.

  9. RAVEN Beta Release

    Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alfonsi, Andrea [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cogliati, Joshua Joseph [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mandelli, Diego [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinoshita, Robert Arthur [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wang, Congjian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Maljovec, Daniel Patrick [Idaho National Lab. (INL), Idaho Falls, ID (United States); Talbot, Paul William [Idaho National Lab. (INL), Idaho Falls, ID (United States)


    This documents the release of the Risk Analysis Virtual Environment (RAVEN) code. A description of the RAVEN code is provided, and discussion of the release process for the M2LW-16IN0704045 milestone. The RAVEN code is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. RAVEN is capable of investigating the system response as well as the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. RAVEN has now increased in maturity enough for the Beta 1.0 release.

  10. Controlled-release microchips.

    Sharma, Sadhana; Nijdam, A Jasper; Sinha, Piyush M; Walczak, Robbie J; Liu, Xuewu; Cheng, Mark M-C; Ferrari, Mauro


    Efficient drug delivery remains an important challenge in medicine: continuous release of therapeutic agents over extended time periods in accordance with a predetermined temporal profile; local delivery at a constant rate to the tumour microenvironment to overcome much of the systemic toxicity and to improve antitumour efficacy; improved ease of administration, and increasing patient compliance required are some of the unmet needs of the present drug delivery technology. Microfabrication technology has enabled the development of novel controlled-release microchips with capabilities not present in the current treatment modalities. In this review, the current status and future prospects of different types of controlled-release microchips are summarised and analysed with reference to microneedle-based microchips, as well as providing an in-depth focus on microreservoir-based and nanoporous microchips.

  11. Self-consistency in Capital Markets

    Benbrahim, Hamid


    Capital Markets are considered, at least in theory, information engines whereby traders contribute to price formation with their diverse perspectives. Regardless whether one believes in efficient market theory on not, actions by individual traders influence prices of securities, which in turn influence actions by other traders. This influence is exerted through a number of mechanisms including portfolio balancing, margin maintenance, trend following, and sentiment. As a result market behaviors emerge from a number of mechanisms ranging from self-consistency due to wisdom of the crowds and self-fulfilling prophecies, to more chaotic behavior resulting from dynamics similar to the three body system, namely the interplay between equities, options, and futures. This talk will address questions and findings regarding the search for self-consistency in capital markets.

  12. Student Effort, Consistency and Online Performance

    Hilde Patron


    Full Text Available This paper examines how student effort, consistency, motivation, and marginal learning, influence student grades in an online course. We use data from eleven Microeconomics courses taught online for a total of 212 students. Our findings show that consistency, or less time variation, is a statistically significant explanatory variable, whereas effort, or total minutes spent online, is not. Other independent variables include GPA and the difference between a pre-test and a post-test. The GPA is used as a measure of motivation, and the difference between a post-test and pre-test as marginal learning. As expected, the level of motivation is found statistically significant at a 99% confidence level, and marginal learning is also significant at a 95% level.

  13. Consistence beats causality in recommender systems

    Zhu, Xuzhen; Hu, Zheng; Zhang, Ping; Zhou, Tao


    The explosive growth of information challenges people's capability in finding out items fitting to their own interests. Recommender systems provide an efficient solution by automatically push possibly relevant items to users according to their past preferences. Recommendation algorithms usually embody the causality from what having been collected to what should be recommended. In this article, we argue that in many cases, a user's interests are stable, and thus the previous and future preferences are highly consistent. The temporal order of collections then does not necessarily imply a causality relationship. We further propose a consistence-based algorithm that outperforms the state-of-the-art recommendation algorithms in disparate real data sets, including \\textit{Netflix}, \\textit{MovieLens}, \\textit{Amazon} and \\textit{Rate Your Music}.

  14. A supersymmetric consistent truncation for conifold solutions

    Cassani, Davide


    We establish a supersymmetric consistent truncation of type IIB supergravity on the T^{1,1} coset space, based on extending the Papadopoulos-Tseytlin ansatz to the full set of SU(2)xSU(2) invariant Kaluza-Klein modes. The five-dimensional model is a gauged N=4 supergravity with three vector multiplets, which incorporates various conifold solutions and is suitable for the study of their dynamics. By analysing the scalar potential we find a family of new non-supersymmetric AdS_5 extrema interpolating between a solution obtained long ago by Romans and a solution employing an Einstein metric on T^{1,1} different from the standard one. Finally, we discuss some simple consistent subtruncations preserving N=2 supersymmetry. One of them is compatible with the inclusion of smeared D7-branes.

  15. Temporally consistent segmentation of point clouds

    Owens, Jason L.; Osteen, Philip R.; Daniilidis, Kostas


    We consider the problem of generating temporally consistent point cloud segmentations from streaming RGB-D data, where every incoming frame extends existing labels to new points or contributes new labels while maintaining the labels for pre-existing segments. Our approach generates an over-segmentation based on voxel cloud connectivity, where a modified k-means algorithm selects supervoxel seeds and associates similar neighboring voxels to form segments. Given the data stream from a potentially mobile sensor, we solve for the camera transformation between consecutive frames using a joint optimization over point correspondences and image appearance. The aligned point cloud may then be integrated into a consistent model coordinate frame. Previously labeled points are used to mask incoming points from the new frame, while new and previous boundary points extend the existing segmentation. We evaluate the algorithm on newly-generated RGB-D datasets.

  16. Foundations of consistent couple stress theory

    Hadjesfandiari, Ali R


    In this paper, we examine the recently developed skew-symmetric couple stress theory and demonstrate its inner consistency, natural simplicity and fundamental connection to classical mechanics. This hopefully will help the scientific community to overcome any ambiguity and skepticism about this theory, especially the validity of the skew-symmetric character of the couple-stress tensor. We demonstrate that in a consistent continuum mechanics, the response of infinitesimal elements of matter at each point decomposes naturally into a rigid body portion, plus the relative translation and rotation of these elements at adjacent points of the continuum. This relative translation and rotation captures the deformation in terms of stretches and curvatures, respectively. As a result, the continuous displacement field and its corresponding rotation field are the primary variables, which remarkably is in complete alignment with rigid body mechanics, thus providing a unifying basis. For further clarification, we also exami...

  17. Consistent Linearized Gravity in Brane Backgrounds

    Aref'eva, I Ya; Mück, W; Viswanathan, K S; Volovich, I V


    A globally consistent treatment of linearized gravity in the Randall-Sundrum background with matter on the brane is formulated. Using a novel gauge, in which the transverse components of the metric are non-vanishing, the brane is kept straight. We analyze the gauge symmetries and identify the physical degrees of freedom of gravity. Our results underline the necessity for non-gravitational confinement of matter to the brane.

  18. Self-consistent model of fermions

    Yershov, V N


    We discuss a composite model of fermions based on three-flavoured preons. We show that the opposite character of the Coulomb and strong interactions between these preons lead to formation of complex structures reproducing three generations of quarks and leptons with all their quantum numbers and masses. The model is self-consistent (it doesn't use input parameters). Nevertheless, the masses of the generated structures match the experimental values.

  19. Consistent formulation of the spacelike axial gauge

    Burnel, A.; Van der Rest-Jaspers, M.


    The usual formulation of the spacelike axial gauge is afflicted with the difficulty that the metric is indefinite while no ghost is involved. We solve this difficulty by introducing a ghost whose elimination is such that the metric becomes positive for physical states. The technique consists in the replacement of the gauge condition nxA = 0 by the weaker one partial/sub 0/nxAroughly-equal0.

  20. Security Policy: Consistency, Adjustments and Restraining Factors

    Yang; Jiemian


    In the 2004 U.S. presidential election, despite well-divided domestic opinions and Kerry's appealing slogan of "Reversing the Trend," a slight majority still voted for George W. Bush in the end. It is obvious that, based on the author's analysis, security agenda such as counter-terrorism and Iraqi issue has contributed greatly to the reelection of Mr. Bush. This also indicates that the security policy of Bush's second term will basically be consistent.……

  1. Self-consistent structure of metallic hydrogen

    Straus, D. M.; Ashcroft, N. W.


    A calculation is presented of the total energy of metallic hydrogen for a family of face-centered tetragonal lattices carried out within the self-consistent phonon approximation. The energy of proton motion is large and proper inclusion of proton dynamics alters the structural dependence of the total energy, causing isotropic lattices to become favored. For the dynamic lattice the structural dependence of terms of third and higher order in the electron-proton interaction is greatly reduced from static lattice equivalents.

  2. Radiometric consistency assessment of hyperspectral infrared sounders

    Wang, L.; Y. Han; Jin, X.; Y. Chen; D. A. Tremblay


    The radiometric and spectral consistency among the Atmospheric Infrared Sounder (AIRS), the Infrared Atmospheric Sounding Interferometer (IASI), and the Cross-track Infrared Sounder (CrIS) is fundamental for the creation of long-term infrared (IR) hyperspectral radiance benchmark datasets for both inter-calibration and climate-related studies. In this study, the CrIS radiance measurements on Suomi National Polar-orbiting Partnership (SNPP) satellite are directly com...

  3. The internal consistency of perfect competition

    Jakob Kapeller; Stephan Pühringer


    This article surveys some arguments brought forward in defense of the theory of perfect competition. While some critics propose that the theory of perfect competition, and thus also the theory of the firm, are logically flawed, (mainstream) economists defend their most popular textbook model by a series of apparently different arguments. Here it is examined whether these arguments are comparable, consistent and convincing from the point of view of philosophy of science.

  4. Tritium adsorption/release behaviour of advanced EU breeder pebbles

    Kolb, Matthias H. H.; Rolli, Rolf; Knitter, Regina


    The tritium loading of current grades of advanced ceramic breeder pebbles with three different lithium orthosilicate (LOS)/lithium metatitanate (LMT) compositions (20-30 mol% LMT in LOS) and pebbles of EU reference material, was performed in a consistent way. The temperature dependent release of the introduced tritium was subsequently investigated by temperature programmed desorption (TPD) experiments to gain insight into the desorption characteristics. The obtained TPD data was decomposed into individual release mechanisms according to well-established desorption kinetics. The analysis showed that the pebble composition of the tested samples does not severely change the release behaviour. Yet, an increased content of lithium metatitanate leads to additional desorption peaks at medium temperatures. The majority of tritium is released by high temperature release mechanisms of chemisorbed tritium, while the release of physisorbed tritium is marginal in comparison. The results allow valuable projections for the tritium release behaviour in a fusion blanket.

  5. Dynamic consistency for Stochastic Optimal Control problems

    Carpentier, Pierre; Cohen, Guy; De Lara, Michel; Girardeau, Pierre


    For a sequence of dynamic optimization problems, we aim at discussing a notion of consistency over time. This notion can be informally introduced as follows. At the very first time step $t_0$, the decision maker formulates an optimization problem that yields optimal decision rules for all the forthcoming time step $t_0, t_1, ..., T$; at the next time step $t_1$, he is able to formulate a new optimization problem starting at time $t_1$ that yields a new sequence of optimal decision rules. This process can be continued until final time $T$ is reached. A family of optimization problems formulated in this way is said to be time consistent if the optimal strategies obtained when solving the original problem remain optimal for all subsequent problems. The notion of time consistency, well-known in the field of Economics, has been recently introduced in the context of risk measures, notably by Artzner et al. (2007) and studied in the Stochastic Programming framework by Shapiro (2009) and for Markov Decision Processes...

  6. CMB lens sample covariance and consistency relations

    Motloch, Pavel; Hu, Wayne; Benoit-Lévy, Aurélien


    Gravitational lensing information from the two and higher point statistics of the cosmic microwave background (CMB) temperature and polarization fields are intrinsically correlated because they are lensed by the same realization of structure between last scattering and observation. Using an analytic model for lens sample covariance, we show that there is one mode, separately measurable in the lensed CMB power spectra and lensing reconstruction, that carries most of this correlation. Once these measurements become lens sample variance dominated, this mode should provide a useful consistency check between the observables that is largely free of sampling and cosmological parameter errors. Violations of consistency could indicate systematic errors in the data and lens reconstruction or new physics at last scattering, any of which could bias cosmological inferences and delensing for gravitational waves. A second mode provides a weaker consistency check for a spatially flat universe. Our analysis isolates the additional information supplied by lensing in a model-independent manner but is also useful for understanding and forecasting CMB cosmological parameter errors in the extended Λ cold dark matter parameter space of dark energy, curvature, and massive neutrinos. We introduce and test a simple but accurate forecasting technique for this purpose that neither double counts lensing information nor neglects lensing in the observables.

  7. Consistent Adjoint Driven Importance Sampling using Space, Energy and Angle

    Peplow, Douglas E. [ORNL; Mosher, Scott W [ORNL; Evans, Thomas M [ORNL


    For challenging radiation transport problems, hybrid methods combine the accuracy of Monte Carlo methods with the global information present in deterministic methods. One of the most successful hybrid methods is CADIS Consistent Adjoint Driven Importance Sampling. This method uses a deterministic adjoint solution to construct a biased source distribution and consistent weight windows to optimize a specific tally in a Monte Carlo calculation. The method has been implemented into transport codes using just the spatial and energy information from the deterministic adjoint and has been used in many applications to compute tallies with much higher figures-of-merit than analog calculations. CADIS also outperforms user-supplied importance values, which usually take long periods of user time to develop. This work extends CADIS to develop weight windows that are a function of the position, energy, and direction of the Monte Carlo particle. Two types of consistent source biasing are presented: one method that biases the source in space and energy while preserving the original directional distribution and one method that biases the source in space, energy, and direction. Seven simple example problems are presented which compare the use of the standard space/energy CADIS with the new space/energy/angle treatments.

  8. Electrosprayed nanoparticle delivery system for controlled release

    Eltayeb, Megdi, E-mail: [Department of Biomedical Engineering, Sudan University of Science and Technology, PO Box 407, Khartoum (Sudan); Stride, Eleanor, E-mail: [Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Headington OX3 7DQ (United Kingdom); Edirisinghe, Mohan, E-mail: [Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE (United Kingdom); Harker, Anthony, E-mail: [London Centre for Nanotechnology, Gordon Street, London WC1H 0AH (United Kingdom); Department of Physics & Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)


    This study utilises an electrohydrodynamic technique to prepare core-shell lipid nanoparticles with a tunable size and high active ingredient loading capacity, encapsulation efficiency and controlled release. Using stearic acid and ethylvanillin as model shell and active ingredients respectively, we identify the processing conditions and ratios of lipid:ethylvanillin required to form nanoparticles. Nanoparticles with a mean size ranging from 60 to 70 nm at the rate of 1.37 × 10{sup 9} nanoparticles per minute were prepared with different lipid:ethylvanillin ratios. The polydispersity index was ≈ 21% and the encapsulation efficiency ≈ 70%. It was found that the rate of ethylvanillin release was a function of the nanoparticle size, and lipid:ethylvanillin ratio. The internal structure of the lipid nanoparticles was studied by transmission electron microscopy which confirmed that the ethylvanillin was encapsulated within a stearic acid shell. Fourier transform infrared spectroscopy analysis indicated that the ethylvanillin had not been affected. Extensive analysis of the release of ethylvanillin was performed using several existing models and a new diffusive release model incorporating a tanh function. The results were consistent with a core-shell structure. - Highlights: • Electrohydrodynamic spraying is used to produce lipid-coated nanoparticles. • A new model is proposed for the release rates of active components from nanoparticles. • The technique has potential applications in food science and medicine. • Electrohydrodynamic processing controlled release lipid nanoparticles.

  9. Nuclear energy release from fragmentation

    Li, Cheng [The Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875 (China); Beijing Radiation Center, Beijing 100875 (China); Souza, S.R. [Instituto de Física, Universidade Federal do Rio de Janeiro Cidade Universitária, Caixa Postal 68528, 21945-970 Rio de Janeiro (Brazil); Tsang, M.B. [The Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875 (China); Beijing Radiation Center, Beijing 100875 (China); National Superconducting Cyclotron Laboratory and Physics and Astronomy Department, Michigan State University, East Lansing, MI 48824 (United States); Zhang, Feng-Shou, E-mail: [The Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875 (China); Beijing Radiation Center, Beijing 100875 (China); Center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000 (China)


    It is well known that binary fission occurs with positive energy gain. In this article we examine the energetics of splitting uranium and thorium isotopes into various numbers of fragments (from two to eight) with nearly equal size. We find that the energy released by splitting {sup 230,232}Th and {sup 235,238}U into three equal size fragments is largest. The statistical multifragmentation model (SMM) is applied to calculate the probability of different breakup channels for excited nuclei. By weighing the probability distributions of fragment multiplicity at different excitation energies, we find the peaks of energy release for {sup 230,232}Th and {sup 235,238}U are around 0.7–0.75 MeV/u at excitation energy between 1.2 and 2 MeV/u in the primary breakup process. Taking into account the secondary de-excitation processes of primary fragments with the GEMINI code, these energy peaks fall to about 0.45 MeV/u.

  10. Nuclear energy release from fragmentation

    Li, Cheng; Souza, S. R.; Tsang, M. B.; Zhang, Feng-Shou


    It is well known that binary fission occurs with positive energy gain. In this article we examine the energetics of splitting uranium and thorium isotopes into various numbers of fragments (from two to eight) with nearly equal size. We find that the energy released by splitting 230,232Th and 235,238U into three equal size fragments is largest. The statistical multifragmentation model (SMM) is applied to calculate the probability of different breakup channels for excited nuclei. By weighing the probability distributions of fragment multiplicity at different excitation energies, we find the peaks of energy release for 230,232Th and 235,238U are around 0.7-0.75 MeV/u at excitation energy between 1.2 and 2 MeV/u in the primary breakup process. Taking into account the secondary de-excitation processes of primary fragments with the GEMINI code, these energy peaks fall to about 0.45 MeV/u.

  11. Publicly Released Prompt Radiation Spectra Suitable for Nuclear Detonation Simulations


    emission. During the Hiroshima and Nagasaki bombings, the prompt radiation contributed from 40%-70% of the free-in-air dose depending on distance from...intermediate- and low -yield thermonuclear weapons for initial radiation shielding calculations No Gritzner, et al. 1976 (EM-1, Low , Henre...Publicly Released Prompt Radiation Spectra Suitable for Nuclear Detonation Simulations DISTRIBUTION A. Approved for public release; distribution is

  12. Enzymatically triggered release of dye model compounds from zeinparticles

    Nieuwland, M.; Papen-Botterhuis, N.E.; Drost, W.C.; Slaghek, T.M.; Erich, B.S.J.F.


    tA responsive release system consisting of biocide encapsulated by the hydrophobic protein zein wasinvestigated, in which a biocide will be released if growth of micro-organisms occurs. Because biociderelease is difficult to detect, a model system using dyes with different size, polarity and charge

  13. Nanoparticle release from dental composites.

    Van Landuyt, K L; Hellack, B; Van Meerbeek, B; Peumans, M; Hoet, P; Wiemann, M; Kuhlbusch, T A J; Asbach, C


    Dental composites typically contain high amounts (up to 60 vol.%) of nanosized filler particles. There is a current concern that dental personnel (and patients) may inhale nanosized dust particles (composite dust was analyzed in real work conditions. Exposure measurements of dust in a dental clinic revealed high peak concentrations of nanoparticles in the breathing zone of both dentist and patient, especially during aesthetic treatments or treatments of worn teeth with composite build-ups. Further laboratory assessment confirmed that all tested composites released very high concentrations of airborne particles in the nanorange (>10(6)cm(-3)). The median diameter of airborne composite dust varied between 38 and 70 nm. Electron microscopic and energy dispersive X-ray analysis confirmed that the airborne particles originated from the composite, and revealed that the dust particles consisted of filler particles or resin or both. Though composite dust exhibited no significant oxidative reactivity, more toxicological research is needed. To conclude, on manipulation with the bur, dental composites release high concentrations of nanoparticles that may enter deeply into the lungs. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  14. Aerosol distribution apparatus

    Hanson, W.D.

    An apparatus for uniformly distributing an aerosol to a plurality of filters mounted in a plenum, wherein the aerosol and air are forced through a manifold system by means of a jet pump and released into the plenum through orifices in the manifold. The apparatus allows for the simultaneous aerosol-testing of all the filters in the plenum.

  15. Characterization of drug-release kinetics in trabecular bone from titania nanotube implants

    Aw MS


    vivo showed a consistent gradual release of model drug from the TNT–Ti implants, with a characteristic three-dimensional distribution into the surrounding bone, over a period of 5 days. The parameters including the flow rate of bone culture medium, differences in trabecular microarchitecture between bone samples, and mechanical loading were found to have the most significant influence on drug distribution in the bone.Conclusion: These results demonstrate the utility of the Zetos™ system for ex vivo drug-release studies in bone, which can be applied to optimize the delivery of specific therapies and to assist in the design of new drug delivery systems. This method has the potential to provide new knowledge to understand drug distribution in the bone environment and to considerably improve existing technologies for local administration in bone, including solving some critical problems in bone therapy and orthopedic implants.Keywords: local drug delivery, Zetos bone bioreactor, drug-releasing implant, drug diffusion

  16. Release of OLe peanut

    OLe is a high oleic Spanish-type peanut that has excellent yield and enhanced Sclerotinia blight and pod rot resistance when compared to other high oleic Spanish cultivars. The purpose for releasing OLe is to provide peanut producers with a true Spanish peanut that is high oleic and has enhanced yi...

  17. Border cell release

    Mravec, Jozef


    Plant border cells are specialised cells derived from the root cap with roles in the biomechanics of root growth and in forming a barrier against pathogens. The mechanism of highly localised cell separation which is essential for their release to the environment is little understood. Here I present...

  18. Wakes in complex plasmas: A self-consistent kinetic theory.

    Kompaneets, Roman; Morfill, Gregor E; Ivlev, Alexei V


    In ground-based experiments with complex (dusty) plasmas, charged microparticles are levitated against gravity by an electric field, which also drives ion flow in the parent gas. Existing analytical approaches to describe the electrostatic interaction between microparticles in such conditions generally ignore the field and ion-neutral collisions, assuming free ion flow with a certain approximation for the ion velocity distribution function (usually a shifted Maxwellian). We provide a comprehensive analysis of our previously proposed self-consistent kinetic theory including the field, ion-neutral collisions, and the corresponding ion velocity distribution. We focus on various limiting cases and demonstrate how the interplay of these factors results in different forms of the shielding potential.

  19. Wakes in complex plasmas: A self-consistent kinetic theory

    Kompaneets, Roman; Morfill, Gregor E.; Ivlev, Alexei V.


    In ground-based experiments with complex (dusty) plasmas, charged microparticles are levitated against gravity by an electric field, which also drives ion flow in the parent gas. Existing analytical approaches to describe the electrostatic interaction between microparticles in such conditions generally ignore the field and ion-neutral collisions, assuming free ion flow with a certain approximation for the ion velocity distribution function (usually a shifted Maxwellian). We provide a comprehensive analysis of our previously proposed self-consistent kinetic theory including the field, ion-neutral collisions, and the corresponding ion velocity distribution. We focus on various limiting cases and demonstrate how the interplay of these factors results in different forms of the shielding potential.

  20. Consistency Relations for the Conformal Mechanism

    Creminelli, Paolo; Khoury, Justin; Simonović, Marko


    We systematically derive the consistency relations associated to the non-linearly realized symmetries of theories with spontaneously broken conformal symmetry but with a linearly-realized de Sitter subalgebra. These identities relate (N+1)-point correlation functions with a soft external Goldstone to N-point functions. These relations have direct implications for the recently proposed conformal mechanism for generating density perturbations in the early universe. We study the observational consequences, in particular a novel one-loop contribution to the four-point function, relevant for the stochastic scale-dependent bias and CMB mu-distortion.

  1. Consistency relations for the conformal mechanism

    Creminelli, Paolo [Abdus Salam International Centre for Theoretical Physics, Strada Costiera 11, 34151, Trieste (Italy); Joyce, Austin; Khoury, Justin [Center for Particle Cosmology, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104 (United States); Simonović, Marko, E-mail:, E-mail:, E-mail:, E-mail: [SISSA, via Bonomea 265, 34136, Trieste (Italy)


    We systematically derive the consistency relations associated to the non-linearly realized symmetries of theories with spontaneously broken conformal symmetry but with a linearly-realized de Sitter subalgebra. These identities relate (N+1)-point correlation functions with a soft external Goldstone to N-point functions. These relations have direct implications for the recently proposed conformal mechanism for generating density perturbations in the early universe. We study the observational consequences, in particular a novel one-loop contribution to the four-point function, relevant for the stochastic scale-dependent bias and CMB μ-distortion.

  2. Improving analytical tomographic reconstructions through consistency conditions

    Arcadu, Filippo; Stampanoni, Marco; Marone, Federica


    This work introduces and characterizes a fast parameterless filter based on the Helgason-Ludwig consistency conditions, used to improve the accuracy of analytical reconstructions of tomographic undersampled datasets. The filter, acting in the Radon domain, extrapolates intermediate projections between those existing. The resulting sinogram, doubled in views, is then reconstructed by a standard analytical method. Experiments with simulated data prove that the peak-signal-to-noise ratio of the results computed by filtered backprojection is improved up to 5-6 dB, if the filter is used prior to reconstruction.

  3. Consistency of non-minimal renormalisation schemes

    Jack, I


    Non-minimal renormalisation schemes such as the momentum subtraction scheme (MOM) have frequently been used for physical computations. The consistency of such a scheme relies on the existence of a coupling redefinition linking it to MSbar. We discuss the implementation of this procedure in detail for a general theory and show how to construct the relevant redefinition up to three-loop order, for the case of a general theory of fermions and scalars in four dimensions and a general scalar theory in six dimensions.

  4. Gentzen's centenary the quest for consistency

    Rathjen, Michael


    Gerhard Gentzen has been described as logic’s lost genius, whom Gödel called a better logician than himself. This work comprises articles by leading proof theorists, attesting to Gentzen’s enduring legacy to mathematical logic and beyond. The contributions range from philosophical reflections and re-evaluations of Gentzen’s original consistency proofs to the most recent developments in proof theory. Gentzen founded modern proof theory. His sequent calculus and natural deduction system beautifully explain the deep symmetries of logic. They underlie modern developments in computer science such as automated theorem proving and type theory.

  5. Consistent Predictions of Future Forest Mortality

    McDowell, N. G.


    We examined empirical and model based estimates of current and future forest mortality of conifers in the northern hemisphere. Consistent water potential thresholds were found that resulted in mortality of our case study species, pinon pine and one-seed juniper. Extending these results with IPCC climate scenarios suggests that most existing trees in this region (SW USA) will be dead by 2050. Further, independent estimates of future mortality for the entire coniferous biome suggest widespread mortality by 2100. The validity and assumptions and implications of these results are discussed.

  6. Surface consistent finite frequency phase corrections

    Kimman, W. P.


    Static time-delay corrections are frequency independent and ignore velocity variations away from the assumed vertical ray path through the subsurface. There is therefore a clear potential for improvement if the finite frequency nature of wave propagation can be properly accounted for. Such a method is presented here based on the Born approximation, the assumption of surface consistency and the misfit of instantaneous phase. The concept of instantaneous phase lends itself very well for sweep-like signals, hence these are the focus of this study. Analytical sensitivity kernels are derived that accurately predict frequency-dependent phase shifts due to P-wave anomalies in the near surface. They are quick to compute and robust near the source and receivers. An additional correction is presented that re-introduces the nonlinear relation between model perturbation and phase delay, which becomes relevant for stronger velocity anomalies. The phase shift as function of frequency is a slowly varying signal, its computation therefore does not require fine sampling even for broad-band sweeps. The kernels reveal interesting features of the sensitivity of seismic arrivals to the near surface: small anomalies can have a relative large impact resulting from the medium field term that is dominant near the source and receivers. Furthermore, even simple velocity anomalies can produce a distinct frequency-dependent phase behaviour. Unlike statics, the predicted phase corrections are smooth in space. Verification with spectral element simulations shows an excellent match for the predicted phase shifts over the entire seismic frequency band. Applying the phase shift to the reference sweep corrects for wavelet distortion, making the technique akin to surface consistent deconvolution, even though no division in the spectral domain is involved. As long as multiple scattering is mild, surface consistent finite frequency phase corrections outperform traditional statics for moderately large

  7. Are there consistent models giving observable NSI ?

    Martinez, Enrique Fernandez


    While the existing direct bounds on neutrino NSI are rather weak, order 10(−)(1) for propagation and 10(−)(2) for production and detection, the close connection between these interactions and new NSI affecting the better-constrained charged letpon sector through gauge invariance make these bounds hard to saturate in realistic models. Indeed, Standard Model extensions leading to neutrino NSI typically imply constraints at the 10(−)(3) level. The question of whether consistent models leading to observable neutrino NSI naturally arises and was discussed in a dedicated session at NUFACT 11. Here we summarize that discussion.

  8. Consistent thermodynamic properties of lipids systems

    Cunico, Larissa; Ceriani, Roberta; Sarup, Bent

    Physical and thermodynamic properties of pure components and their mixtures are the basic requirement for process design, simulation, and optimization. In the case of lipids, our previous works[1-3] have indicated a lack of experimental data for pure components and also for their mixtures...... different pressures, with azeotrope behavior observed. Available thermodynamic consistency tests for TPx data were applied before performing parameter regressions for Wilson, NRTL, UNIQUAC and original UNIFAC models. The relevance of enlarging experimental databank of lipids systems data in order to improve...

  9. Consistency Checking of Web Service Contracts

    Cambronero, M. Emilia; Okika, Joseph C.; Ravn, Anders Peter


    Behavioural properties are analyzed for web service contracts formulated in Business Process Execution Language (BPEL) and Choreography Description Language (CDL). The key result reported is an automated technique to check consistency between protocol aspects of the contracts. The contracts...... are abstracted to (timed) automata and from there a simulation is set up, which is checked using automated tools for analyzing networks of finite state processes. Here we use the Concurrency Work Bench. The proposed techniques are illustrated with a case study that include otherwise difficult to analyze fault...

  10. Bootstrap consistency for general semiparametric M-estimation

    Cheng, Guang


    Consider M-estimation in a semiparametric model that is characterized by a Euclidean parameter of interest and an infinite-dimensional nuisance parameter. As a general purpose approach to statistical inferences, the bootstrap has found wide applications in semiparametric M-estimation and, because of its simplicity, provides an attractive alternative to the inference approach based on the asymptotic distribution theory. The purpose of this paper is to provide theoretical justifications for the use of bootstrap as a semiparametric inferential tool. We show that, under general conditions, the bootstrap is asymptotically consistent in estimating the distribution of the M-estimate of Euclidean parameter; that is, the bootstrap distribution asymptotically imitates the distribution of the M-estimate. We also show that the bootstrap confidence set has the asymptotically correct coverage probability. These general onclusions hold, in particular, when the nuisance parameter is not estimable at root-n rate, and apply to a broad class of bootstrap methods with exchangeable ootstrap weights. This paper provides a first general theoretical study of the bootstrap in semiparametric models. © Institute of Mathematical Statistics, 2010.

  11. Sludge characterization: the role of physical consistency

    Spinosa, Ludovico; Wichmann, Knut


    The physical consistency is an important parameter in sewage sludge characterization as it strongly affects almost all treatment, utilization and disposal operations. In addition, in many european Directives a reference to the physical consistency is reported as a characteristic to be evaluated for fulfilling the regulations requirements. Further, in many analytical methods for sludge different procedures are indicated depending on whether a sample is liquid or not, is solid or not. Three physical behaviours (liquid, paste-like and solid) can be observed with sludges, so the development of analytical procedures to define the boundary limit between liquid and paste-like behaviours (flowability) and that between solid and paste-like ones (solidity) is of growing interest. Several devices can be used for evaluating the flowability and solidity properties, but often they are costly and difficult to be operated in the field. Tests have been carried out to evaluate the possibility to adopt a simple extrusion procedure for flowability measurements, and a Vicat needle for solidity ones. (author)

  12. Probability-consistent spectrum and code spectrum

    沈建文; 石树中


    In the seismic safety evaluation (SSE) for key projects, the probability-consistent spectrum (PCS), usually obtained from probabilistic seismic hazard analysis (PSHA), is not consistent with the design response spectrum given by Code for Seismic Design of Buildings (GB50011-2001). Sometimes, there may be a remarkable difference between them. If the PCS is lower than the corresponding code design response spectrum (CDS), the seismic fortification criterion for the key projects would be lower than that for the general industry and civil buildings. In the paper, the relation between PCS and CDS is discussed by using the ideal simple potential seismic source. The results show that in the most areas influenced mainly by the potential sources of the epicentral earthquakes and the regional earthquakes, PCS is generally lower than CDS in the long periods. We point out that the long-period response spectra of the code should be further studied and combined with the probability method of seismic zoning as much as possible. Because of the uncertainties in SSE, it should be prudent to use the long-period response spectra given by SSE for key projects when they are lower than CDS.

  13. Consistent mutational paths predict eukaryotic thermostability

    van Noort Vera


    Full Text Available Abstract Background Proteomes of thermophilic prokaryotes have been instrumental in structural biology and successfully exploited in biotechnology, however many proteins required for eukaryotic cell function are absent from bacteria or archaea. With Chaetomium thermophilum, Thielavia terrestris and Thielavia heterothallica three genome sequences of thermophilic eukaryotes have been published. Results Studying the genomes and proteomes of these thermophilic fungi, we found common strategies of thermal adaptation across the different kingdoms of Life, including amino acid biases and a reduced genome size. A phylogenetics-guided comparison of thermophilic proteomes with those of other, mesophilic Sordariomycetes revealed consistent amino acid substitutions associated to thermophily that were also present in an independent lineage of thermophilic fungi. The most consistent pattern is the substitution of lysine by arginine, which we could find in almost all lineages but has not been extensively used in protein stability engineering. By exploiting mutational paths towards the thermophiles, we could predict particular amino acid residues in individual proteins that contribute to thermostability and validated some of them experimentally. By determining the three-dimensional structure of an exemplar protein from C. thermophilum (Arx1, we could also characterise the molecular consequences of some of these mutations. Conclusions The comparative analysis of these three genomes not only enhances our understanding of the evolution of thermophily, but also provides new ways to engineer protein stability.

  14. Viewpoint Consistency: An Eye Movement Study

    Filipe Cristino


    Full Text Available Eye movements have been widely studied, using images and videos in laboratories or portable eye trackers in the real world. Although a good understanding of the saccadic system and extensive models of gaze have been developed over the years, only a few studies have focused on the consistency of eye movements across viewpoints. We have developed a new technique to compute and map the depth of collected eye movements on stimuli rendered from 3D mesh objects using a traditional corneal reflection eye tracker (SR Eyelink 1000. Having eye movements mapped into 3D space (and not on an image space allowed us to compare fixations across viewpoints. Fixation sequences (scanpaths were also studied across viewpoints using the ScanMatch method (Cristino et al 2010, Behavioural and Research Methods 42, 692–700, extended to work with 3D eye movements. In a set of experiments where participants were asked to perform a recognition task on either a set of objects or faces, we recorded their gaze while performing the task. Participants either viewed the stimuli in 2D or using anaglyph glasses. The stimuli were shown from different viewpoints during the learning and testing phases. A high degree of gaze consistency was found across the different viewpoints, particularly between learning and testing phases. Scanpaths were also similar across viewpoints, suggesting not only that the gazed spatial locations are alike, but also their temporal order.

  15. Subgame consistent cooperation a comprehensive treatise

    Yeung, David W K


    Strategic behavior in the human and social world has been increasingly recognized in theory and practice. It is well known that non-cooperative behavior could lead to suboptimal or even highly undesirable outcomes. Cooperation suggests the possibility of obtaining socially optimal solutions and the calls for cooperation are prevalent in real-life problems. Dynamic cooperation cannot be sustainable if there is no guarantee that the agreed upon optimality principle at the beginning is maintained throughout the cooperation duration. It is due to the lack of this kind of guarantees that cooperative schemes fail to last till its end or even fail to get started. The property of subgame consistency in cooperative dynamic games and the corresponding solution mechanism resolve this “classic” problem in game theory. This book is a comprehensive treatise on subgame consistent dynamic cooperation covering the up-to-date state of the art analyses in this important topic. It sets out to provide the theory, solution tec...

  16. 11.1%吡虫啉缓释片剂在西瓜根区土壤的释放分布及在西瓜中的残留量分析%Release and distribution of 11 . 1% imidacloprid in root zone of watermelon field soil with applicaton of sustained release tablet formulation and its residue in watermelon

    周晓静; 吴迪; 周春江; 恽友兰; 李松林; 田晓莉


    为了评价11.1%吡虫啉缓释片剂对西瓜蚜虫的防治效果和安全性,于2012-2013年通过田间试验于西瓜移栽时施药,研究了11.1%吡虫啉缓释片剂对西瓜蚜虫的防治效果,及其在瓜秧、果实和土壤中的残留量。结果表明:西瓜苗移栽时将11.1%吡虫啉缓释片剂(吡虫啉有效成分0.08 g/株)施入其根部下方,施药后42 d对西瓜蚜虫的防治效果为83.3%,基本可满足全生育期防治的需要。2012和2013年,11.1%吡虫啉缓释片剂在西瓜采收期(药后/移栽后60 d)的累积释放率分别为15%和32%。与吡虫啉原药处理相比,片剂中的吡虫啉在土壤中的迁移范围较小,药后30 d,施药点下方10 cm外、水平方向6 cm外的吡虫啉残留量低于0.2 mg/kg。此外,施药点下方2~4 cm处、水平方向2~4 cm处土壤中吡虫啉的残留动态基本呈单峰曲线变化,峰值均出现在药后30 d,分别为1.91和0.10 mg/kg;药后120 d 分别为0.17和0.03 mg/kg。基部瓜秧中(2012年:0~30 cm;2013年:1~3节)吡虫啉的含量于药后14 d检出,其余时期均未检出;2年试验中,西瓜果实中的吡虫啉残留量均低于最低检测浓度(LOQ)0.05 mg/kg,也低于食品法典委员会( CAC)规定的西瓜中最大残留限量( MRL)0.2 mg/kg。%In order to evaluate the control effect of 11. 1% sustained release tablet ( SRT ) of imidacloprid on melon aphid ( Aphis gossypii Glover ) in watermelon and its application safety to watermelon and environment, the experiments were conducted in open field during growing season of watermelon ( Citrullus lanatus ) at Beijing in 2012 -2013 . The 11. 1% sustained release tablets of imidacloprid ( equivalent to 0. 08 g imidacloprid per plant) were applied under the roots of watermelon seedlings while transplanting. The results indicated that the control effect of imidacloprid SRT on melon aphid basically covered the whole growing season ( 60 d ) of watermelon

  17. Sustained-release from nanocarriers: a review.

    Natarajan, Jayaganesh V; Nugraha, Chandra; Ng, Xu Wen; Venkatraman, Subbu


    Nanocarriers have been explored for delivering drugs and other bioactive molecules for well over 35years. Since the introduction of Doxil®, a nanoliposomal delivery system for the cancer drug doxorubicin, several products have been approved worldwide. The majority of these products focus on cancer chemotherapy, and utilize the size advantage of nanocarriers to obtain a favourable distribution of the drug carrier in the human body. In general, such carriers do not sustain drug release over more than a few days at best. In this review, we explore the reasons for this, and present an overview of successful research that is capable of generating sustained-release products in non-cancer applications. A variety of nanocarriers have been studied, and their advantages and shortcomings are highlighted in this review. The achievement of sustained release of bioactive molecules opens new doors in nanotherapeutics.

  18. Post-release survival and feeding in reared turbot

    Sparrevohn, Claus Reedtz; Støttrup, Josianne


    was estimated to be restricted to three days after release. The only active predators observed in the area were birds. Besides estimating mortality the diffusion model provides an estimate on the catchability of the released turbot when fished with a juvenile flatfish-trawl. Catchabilities varied between 38...... until day 8, using a juvenile flatfish-trawl to recapture the fish. The catches were analyzed on the basis of a normal distribution approximation method, founded in diffusion theory, from which daily abundance of the released fish and hence post-release mortality could be estimated. The group of Large...

  19. Gravitational wave consistency relations for multifield inflation.

    Price, Layne C; Peiris, Hiranya V; Frazer, Jonathan; Easther, Richard


    We study the tensor spectral index n(t) and the tensor-to-scalar ratio r in the simplest multifield extension to single-field, slow-roll inflation models. We show that multifield models with potentials V∼[under ∑]iλ_{i}|ϕ_{i}|^{p} have different predictions for n(t)/r than single-field models, even when all the couplings are equal λ_{i}=λ_{j}, due to the probabilistic nature of the fields' initial values. We analyze well-motivated prior probabilities for the λ_{i} and initial conditions to make detailed predictions for the marginalized probability distribution of n(t)/r. With O(100) fields and p>3/4, we find that n(t)/r differs from the single-field result of n(t)/r=-1/8 at the 5σ level. This gives a novel and testable prediction for the simplest multifield inflation models.

  20. Fast Drug Release Using Rotational Motion of Magnetic Gel Beads

    Jun-Ichi Takimoto


    Full Text Available Accelerated drug release has been achieved by means of the fast rotation of magnetic gel beads. The magnetic gel bead consists of sodium alginate crosslinked by calcium chlorides, which contains barium ferrite of ferrimagnetic particles, and ketoprofen as a drug. The bead underwent rotational motion in response to rotational magnetic fields. In the case of bead without rotation, the amount of drug release into a phosphate buffer solution obeyed non-Fickian diffusion. The spontaneous drug release reached a saturation value of 0.90 mg at 25 minutes, which corresponds to 92% of the perfect release. The drug release was accelerated with increasing the rotation speed. The shortest time achieving the perfect release was approximately 3 minutes, which corresponds to 1/8 of the case without rotation. Simultaneous with the fast release, the bead collapsed probably due to the strong water flow surrounding the bead. The beads with high elasticity were hard to collapse and the fast release was not observed. Hence, the fast release of ketoprofen is triggered by the collapse of beads. Photographs of the collapse of beads, time profiles of the drug release, and a pulsatile release modulated by magnetic fields were presented.

  1. Circadian regulation of cortisol release in behaviorally split golden hamsters.

    Lilley, Travis R; Wotus, Cheryl; Taylor, Daniel; Lee, Jennifer M; de la Iglesia, Horacio O


    The master circadian clock located within the hypothalamic suprachiasmatic nucleus (SCN) is necessary for the circadian rhythm of glucocorticoid (GC) release. The pathways by which the SCN sustains rhythmic GC release remain unclear. We studied the circadian regulation of cortisol release in the behaviorally split golden hamster, in which the single bout of circadian locomotor activity splits into two bouts approximately 12 h apart after exposing the animals to constant light conditions. We show that unsplit control hamsters present a single peak of cortisol release that is concomitant with a single peak of ACTH release. In contrast, split hamsters show two peaks of cortisol release that are approximately 12 h appart and are appropriately phased to each locomotor activity bout but surprisingly do not rely on rhythmic release of ACTH. Our results are consistent with a model in which the circadian pacemaker within the SCN regulates the circadian release of GC via input to the hypothalamo-pituitary-adrenal axis and via a second regulatory pathway, which likely involves sympathetic innervation of the adrenal and can operate even in the absence of ACTH circadian rhythmic release. Furthermore, we show that although the overall 24-h cortisol output in split hamsters is lower than in unsplit controls, split hamsters release constant low levels of ACTH. This result suggests that the timing, rather than the absolute amount, of cortisol release is more critical for the induction of negative feedback effects that regulate the hypothalamo-pituitary-adrenal axis.

  2. 纳米载银树脂中抗菌剂的分散及银离子析出的观察%Silver-ion release and particle distribution of denture base resin containing nanometer-sized silver supposed antimicrobial agent

    余日月; 周永胜; 冯海兰; 刘希云


    目的 研究纳米载银树脂中抗菌剂的分散及银离子的析出情况,为进一步研究其加工工艺、抗菌长效性及使用安全性提供依据.方法 用球磨法将以磷酸复盐为载体的纳米载银抗菌剂STR-1按一定比例添加到义齿基托聚合物粉体中,制作抗菌剂浓度分别为0、5和10 g/L的3组纳米载银树脂片各6片,其中3片规格为10 mm×10 mm×1 mm,用于扫描电镜观察树脂片表面抗菌剂的分散情况;另外3片规格为70 mm×70 mm×2.5 mm,分别浸泡在人工唾液中,每24 h取样1次,用电感耦合等离子质谱法测定银离子的平均析出量,观察54 d.结果 扫描电镜下可见纳米载银抗菌剂在树脂片中分散较均匀,有少量较小的团聚体,无大的团聚体形成;抗菌剂含量为5 g/L和10 g/L的纳米载银树脂片在人工唾液中浸泡54 d后累积析出银离子分别为0.953 μg和2.520 μg,分别占各自银离子总含量的0.026%和0.034%.银离子析出速度非常缓慢,银离子累积析出曲线呈"S"型,早期析出缓慢,中期析出相对加速,后期又趋于缓慢、稳定.结论 纳米载银抗菌剂STR-1可较均匀地分散于树脂中,54 d内纳米载银树脂中银离子析出微量且速度缓慢.%Objective To investigate the distribution of antimicrobial agent STR-1 of nanometer level which was incorporated with ball-grinding method in the polymethylmethacrylate(PMMA)denture base,and to study the release mode of silver ions from the base. Methods The distribution of the antimierobial agent in the PMMA denture base containing STR-1 at concentrations of 0 g/L,5 g/L,and 10 g/L Was examined with scanning electronic microscopy. Then,PMMA resin bases containing STR-1 at the three concentrations were respectively immersed in artificial saliva at 37 ℃ f0r 54 days. The release of silver ions from the resin bases was surveyed with inductively coupled plasma-mass spectroscopy(ICP-MS)every 24 hours.Results The antimicrobial agent incorporated by

  3. Consistent evolution in a pedestrian flow

    Guan, Junbiao; Wang, Kaihua


    In this paper, pedestrian evacuation considering different human behaviors is studied by using a cellular automaton (CA) model combined with the snowdrift game theory. The evacuees are divided into two types, i.e. cooperators and defectors, and two different human behaviors, herding behavior and independent behavior, are investigated. It is found from a large amount of numerical simulations that the ratios of the corresponding evacuee clusters are evolved to consistent states despite 11 typically different initial conditions, which may largely owe to self-organization effect. Moreover, an appropriate proportion of initial defectors who are of herding behavior, coupled with an appropriate proportion of initial defectors who are of rationally independent thinking, are two necessary factors for short evacuation time.

  4. Consistency of warm k-inflation

    Peng, Zhi-Peng; Zhang, Xiao-Min; Zhu, Jian-Yang


    We extend the k-inflation which is a type of kinetically driven inflationary model under the standard inflationary scenario to a possible warm inflationary scenario. The dynamical equations of this warm k-inflation model are obtained. We rewrite the slow-roll parameters which are different from the usual potential driven inflationary models and perform a linear stability analysis to give the proper slow-roll conditions in the warm k-inflation. Two cases, a power-law kinetic function and an exponential kinetic function, are studied, when the dissipative coefficient $\\Gamma=\\Gamma_0$ and $\\Gamma=\\Gamma(\\phi)$, respectively. A proper number of e-folds is obtained in both concrete cases of warm k-inflation. We find a constant dissipative coefficient ($\\Gamma=\\Gamma_0$) is not a workable choice for these two cases while the two cases with $\\Gamma=\\Gamma(\\phi)$ are self-consistent warm inflationary models.

  5. Compact difference approximation with consistent boundary condition

    FU Dexun; MA Yanwen; LI Xinliang; LIU Mingyu


    For simulating multi-scale complex flow fields it should be noted that all the physical quantities we are interested in must be simulated well. With limitation of the computer resources it is preferred to use high order accurate difference schemes. Because of their high accuracy and small stencil of grid points computational fluid dynamics (CFD) workers pay more attention to compact schemes recently. For simulating the complex flow fields the treatment of boundary conditions at the far field boundary points and near far field boundary points is very important. According to authors' experience and published results some aspects of boundary condition treatment for far field boundary are presented, and the emphasis is on treatment of boundary conditions for the upwind compact schemes. The consistent treatment of boundary conditions at the near boundary points is also discussed. At the end of the paper are given some numerical examples. The computed results with presented method are satisfactory.

  6. Consistency of canonical formulation of Horava gravity

    Soo, Chopin, E-mail: [Department of Physics, National Cheng Kung University, Tainan, Taiwan (China)


    Both the non-projectable and projectable version of Horava gravity face serious challenges. In the non-projectable version, the constraint algebra is seemingly inconsistent. The projectable version lacks a local Hamiltonian constraint, thus allowing for an extra graviton mode which can be problematic. A new formulation (based on arXiv:1007.1563) of Horava gravity which is naturally realized as a representation of the master constraint algebra (instead of the Dirac algebra) studied by loop quantum gravity researchers is presented. This formulation yields a consistent canonical theory with first class constraints; and captures the essence of Horava gravity in retaining only spatial diffeomorphisms as the physically relevant non-trivial gauge symmetry. At the same time the local Hamiltonian constraint is equivalently enforced by the master constraint.

  7. Trisomy 21 consistently activates the interferon response.

    Sullivan, Kelly D; Lewis, Hannah C; Hill, Amanda A; Pandey, Ahwan; Jackson, Leisa P; Cabral, Joseph M; Smith, Keith P; Liggett, L Alexander; Gomez, Eliana B; Galbraith, Matthew D; DeGregori, James; Espinosa, Joaquín M


    Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells show increased induction of interferon-stimulated genes and decreased expression of ribosomal proteins and translation factors. An shRNA screen determined that the interferon-activated kinases JAK1 and TYK2 suppress proliferation of trisomy 21 fibroblasts, and this defect is rescued by pharmacological JAK inhibition. Therefore, we propose that interferon activation, likely via increased gene dosage of the four interferon receptors encoded on chromosome 21, contributes to many of the clinical impacts of trisomy 21, and that interferon antagonists could have therapeutic benefits.

  8. On the consistent use of Constructed Observables

    Trott, Michael


    We define "constructed observables" as relating experimental measurements to terms in a Lagrangian while simultaneously making assumptions about possible deviations from the Standard Model (SM), in other Lagrangian terms. Ensuring that the SM effective field theory (EFT) is constrained correctly when using constructed observables requires that their defining conditions are imposed on the EFT in a manner that is consistent with the equations of motion. Failing to do so can result in a "functionally redundant" operator basis and the wrong expectation as to how experimental quantities are related in the EFT. We illustrate the issues involved considering the $\\rm S$ parameter and the off shell triple gauge coupling (TGC) verticies. We show that the relationships between $h \\rightarrow V \\bar{f} \\, f$ decay and the off shell TGC verticies are subject to these subtleties, and how the connections between these observables vanish in the limit of strong bounds due to LEP. The challenge of using constructed observables...

  9. Consistently weighted measures for complex network topologies

    Heitzig, Jobst; Zou, Yong; Marwan, Norbert; Kurths, Jürgen


    When network and graph theory are used in the study of complex systems, a typically finite set of nodes of the network under consideration is frequently either explicitly or implicitly considered representative of a much larger finite or infinite set of objects of interest. The selection procedure, e.g., formation of a subset or some kind of discretization or aggregation, typically results in individual nodes of the studied network representing quite differently sized parts of the domain of interest. This heterogeneity may induce substantial bias and artifacts in derived network statistics. To avoid this bias, we propose an axiomatic scheme based on the idea of {\\em node splitting invariance} to derive consistently weighted variants of various commonly used statistical network measures. The practical relevance and applicability of our approach is demonstrated for a number of example networks from different fields of research, and is shown to be of fundamental importance in particular in the study of climate n...

  10. Consistent 4-form fluxes for maximal supergravity

    Godazgar, Hadi; Krueger, Olaf; Nicolai, Hermann


    We derive new ansaetze for the 4-form field strength of D=11 supergravity corresponding to uplifts of four-dimensional maximal gauged supergravity. In particular, the ansaetze directly yield the components of the 4-form field strength in terms of the scalars and vectors of the four-dimensional maximal gauged supergravity---in this way they provide an explicit uplift of all four-dimensional consistent truncations of D=11 supergravity. The new ansaetze provide a substantially simpler method for uplifting d=4 flows compared to the previously available method using the 3-form and 6-form potential ansaetze. The ansatz for the Freund-Rubin term allows us to conjecture a `master formula' for the latter in terms of the scalar potential of d=4 gauged supergravity and its first derivative. We also resolve a long-standing puzzle concerning the antisymmetry of the flux obtained from uplift ansaetze.

  11. Internal Branding and Employee Brand Consistent Behaviours

    Mazzei, Alessandra; Ravazzani, Silvia


    Employee behaviours conveying brand values, named brand consistent behaviours, affect the overall brand evaluation. Internal branding literature highlights a knowledge gap in terms of communication practices intended to sustain such behaviours. This study contributes to the development of a non......-normative and constitutive approach to internal branding by proposing an enablement-oriented communication approach. The conceptual background presents a holistic model of the inside-out process of brand building. This model adopts a theoretical approach to internal branding as a nonnormative practice that facilitates...... constitutive processes. In particular, the paper places emphasis on the role and kinds of communication practices as a central part of the nonnormative and constitutive internal branding process. The paper also discusses an empirical study based on interviews with 32 Italian and American communication managers...

  12. Thermoacoustic Instability in a Rijke Tube with a Distributed Heat Source

    Xiaochuan Yang


    Full Text Available A Rijke tube with a distributed heat source is investigated. Driven by the widely existing thermoacoustic instability in lean premixed gas turbine combustors, this work aims to explore the physicochemical underpinning and assist in the elucidation and analysis of this problem. The heat release model consists of a row of distributed heat sources with individual heat release rates. The integrated heat release rate is then coupled with the acoustic perturbation for thermoacoustic analysis. A continuation approach is employed to conduct the bifurcation analysis and capture the nonlinear behaviour inherent in the system. Unlike the conventional approach by the Galerkin method, the acoustic equations are originally discretized using the Method of Lines (MOL to build up a dynamic system. The model is first validated and shown to yield good predictions with available experimental data. Influences of multiple heat sources, time delay, and heat release distribution are then studied to reveal the extensive nonlinear characteristics involved in the case of a distributed heat source. It is found that distributed heat source plays an important role in determining the stability of a thermoacoustic system.

  13. Thermodynamically consistent model calibration in chemical kinetics

    Goutsias John


    Full Text Available Abstract Background The dynamics of biochemical reaction systems are constrained by the fundamental laws of thermodynamics, which impose well-defined relationships among the reaction rate constants characterizing these systems. Constructing biochemical reaction systems from experimental observations often leads to parameter values that do not satisfy the necessary thermodynamic constraints. This can result in models that are not physically realizable and may lead to inaccurate, or even erroneous, descriptions of cellular function. Results We introduce a thermodynamically consistent model calibration (TCMC method that can be effectively used to provide thermodynamically feasible values for the parameters of an open biochemical reaction system. The proposed method formulates the model calibration problem as a constrained optimization problem that takes thermodynamic constraints (and, if desired, additional non-thermodynamic constraints into account. By calculating thermodynamically feasible values for the kinetic parameters of a well-known model of the EGF/ERK signaling cascade, we demonstrate the qualitative and quantitative significance of imposing thermodynamic constraints on these parameters and the effectiveness of our method for accomplishing this important task. MATLAB software, using the Systems Biology Toolbox 2.1, can be accessed from lab/software.html. An SBML file containing the thermodynamically feasible EGF/ERK signaling cascade model can be found in the BioModels database. Conclusions TCMC is a simple and flexible method for obtaining physically plausible values for the kinetic parameters of open biochemical reaction systems. It can be effectively used to recalculate a thermodynamically consistent set of parameter values for existing thermodynamically infeasible biochemical reaction models of cellular function as well as to estimate thermodynamically feasible values for the parameters of new

  14. Application of advanced polymeric materials for controlled release pesticides

    Rahim, M.; Hakim, M. R.; Haris, H. M.


    The objective of this work was to study the capability of advanced polymeric material constituted by chitosan and natural rubber matrices for controlled release of pesticides (1-hydroxynaphthalene and 2-hydroxynaphthalene) in aqueous solution. The released amount of pesticides was measured spectrophotometrically from the absorbance spectra applying a standardized curve. The release of the pesticides was studied into refreshing and non-refreshing neutral aqueous media. Interestingly, formulation successfully indicated a consistent, controlled and prolonged release of pesticides over a period of 35 days.

  15. Modeling controlled nutrient release from polymer coated fertilizers: diffusion release from single granules.

    Shaviv, Avi; Raban, Smadar; Zaidel, Elina


    A comprehensive model describing the complex and "non-Fickian" (mathematically nonlinear) nature of the release from single granules of membrane coated, controlled release fertilizers (CRFs) is proposed consisting of three stages: i. a lag period during which water penetrates the coating of the granule dissolving part of the solid fertilizer in it ii. a period of linear release during which water penetration into and release out occur concomitantly while the total volume of the granules remains practically constant; and iii. a period of "decaying release", starting as the concentration inside the granule starts to decrease. A mathematical model was developed based on vapor and nutrient diffusion equations. The model predicts the release stages in terms of measurable geometrical and chemophysical parameters such as the following: the product of granule radius and coating thickness, water and solute permeability, saturation concentration of the fertilizer, and its density. The model successfully predicts the complex and "sigmoidal" pattern of release that is essential for matching plant temporal demand to ensure high agronomic and environmental effectiveness. It also lends itself to more complex statistical formulations which account for the large variability within large populations of coated CRFs and can serve for further improving CRF production and performance.

  16. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: modelling the clustering and halo occupation distribution of BOSS CMASS galaxies in the Final Data Release

    Rodríguez-Torres, Sergio A.; Chuang, Chia-Hsun; Prada, Francisco; Guo, Hong; Klypin, Anatoly; Behroozi, Peter; Hahn, Chang Hoon; Comparat, Johan; Yepes, Gustavo; Montero-Dorta, Antonio D.; Brownstein, Joel R.; Maraston, Claudia; McBride, Cameron K.; Tinker, Jeremy; Gottlöber, Stefan; Favole, Ginevra; Shu, Yiping; Kitaura, Francisco-Shu; Bolton, Adam; Scoccimarro, Román; Samushia, Lado; Schlegel, David; Schneider, Donald P.; Thomas, Daniel


    We present a study of the clustering and halo occupation distribution of Baryon Oscillation Spectroscopic Survey (BOSS) CMASS galaxies in the redshift range 0.43 veto masks and fibre collisions are included in the model, which reproduces within 1σ errors the observed monopole of the two-point correlation function at all relevant scales: from the smallest scales, 0.5 h-1 Mpc, up to scales beyond the baryon acoustic oscillation feature. This model also agrees remarkably well with the BOSS galaxy power spectrum (up to k ˜ 1 h Mpc-1), and the three-point correlation function. The quadrupole of the correlation function presents some tensions with observations. We discuss possible causes that can explain this disagreement, including target selection effects. Overall, the standard HAM model describes remarkably well the clustering statistics of the CMASS sample. We compare the stellar-to-halo mass relation for the CMASS sample measured using weak lensing in the Canada-France-Hawaii Telescope Stripe 82 Survey with the prediction of our clustering model, and find a good agreement within 1σ. The BigMD-BOSS light cone including properties of BOSS galaxies and halo properties is made publicly available.

  17. On-demand antimicrobial release from a temperature-sensitive polymer - comparison with ad libitum release from central venous catheters.

    Sjollema, Jelmer; Dijkstra, Rene J B; Abeln, Caroline; van der Mei, Henny C; van Asseldonk, Dirk; Busscher, Henk J


    Antimicrobial releasing biomaterial coatings have found application for instance in the fixation of orthopedic joint prostheses and central venous catheters. Most frequently, the release kinetics is such that antimicrobially-effective concentrations are only reached within the first days to weeks after implantation, leaving no local antimicrobial release available when a biomaterial-associated infection occurs later. Here we compare the ad libitum release of chlorhexidine and silver-sulfadiazine from a central venous catheter with their release from a new, on-demand release coating consisting of a temperature-sensitive copolymer of styrene and n-butyl (meth)acrylate. The copolymer can be loaded with an antimicrobial, which is released when the temperature is raised above its glass transition temperature. Ad libitum release of chlorhexidine and silver-sulfadiazine from a commercially-purchased catheter and associated antimicrobial efficacy against Staphylococcus aureus was limited to 16days. Consecutive temperature-triggers of our on-demand coating yielded little or no antimicrobial efficacy of silver-acetate release, but antimicrobially-effective chlorhexidine concentrations were observed over a time period of 60-80days. This attests to the clear advantage of on-demand coatings above ad libitum releasing coatings, that may have released their antimicrobial content before it is actually needed. Importantly, glass transition temperature of chlorhexidine loaded copolymers was lower (48°C) than of silver loaded ones (61°C), facilitating their clinical use.

  18. Carpal tunnel release

    Larsen, Morten Bo; Sørensen, A I; Crone, K L;


    A single-blind, randomized, controlled trial was done to compare the results of carpal tunnel release using classic incision, short incision, or endoscopic technique. In total, 90 consecutive cases were included. Follow-up was 24 weeks. We found a significantly shorter sick leave in the endoscopi...... incision could be found. There were no serious complications in either group. The results indicate that the endoscopic procedure is safe and has the benefit of faster rehabilitation and return to work....

  19. Cryogenic hydrogen release research.

    LaFleur, Angela Christine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    The objective of this project was to devolop a plan for modifying the Turbulent Combustion Laboratory (TCL) with the necessary infrastructure to produce a cold (near liquid temperature) hydrogen jet. The necessary infrastructure has been specified and laboratory modifications are currently underway. Once complete, experiments from this platform will be used to develop and validate models that inform codes and standards which specify protection criteria for unintended releases from liquid hydrogen storage, transport, and delivery infrastructure.

  20. EIA new releases


    This report was prepared by the Energy Information Administration. It contains news releases on items of interest to the petroleum, coal, nuclear, electric and alternate fuels industries ranging from economic outlooks to environmental concerns. There is also a listing of reports by industry and an energy education resource listing containing sources for free or low-cost energy-related educational materials for educators and primary and secondary students.

  1. Contact: Releasing the news

    Pinotti, Roberto

    The problem of mass behavior after man's future contacts with other intelligences in the universe is not only a challenge for social scientists and political leaders all over the world, but also a cultural time bomb as well. In fact, since the impact of CETI (Contact with Extraterrestrial Intelligence) on human civilization, with its different cultures, might cause a serious socio-anthropological shock, a common and predetermined worldwide strategy is necessary in releasing the news after the contact, in order to keep possible manifestations of fear, panic and hysteria under control. An analysis of past studies in this field and of parallel historical situations as analogs suggests a definite "authority crisis" in the public as a direct consequence of an unexpected release of the news, involving a devastating "chain reaction" process (from both the psychological and sociological viewpoints) of anomie and maybe the collapse of today's society. The only way to prevent all this is to prepare the world's public opinion concerning contact before releasing the news, and to develop a long-term strategy through the combined efforts of scientists, political leaders, intelligence agencies and the mass media, in order to create the cultural conditions in which a confrontation with ETI won't affect mankind in a traumatic way. Definite roles and tasks in this multi-level model are suggested.

  2. Synthesis, characterization and drug release properties of 3D chitosan/clinoptilolite biocomposite cryogels.

    Dinu, Maria Valentina; Cocarta, Ana Irina; Dragan, Ecaterina Stela


    Three-dimensional (3D) biocomposites based on chitosan (CS) and clinoptilolite (CPL) were prepared by cryogelation and their potential application as drug carriers was investigated. Variation of CPL content from 0 to 33wt.% allowed the formation of biocomposites with heterogeneous morphologies consisting of randomly distributed pores. The further increase of CPL content led to ordered porous architectures where parallel pore channels were observed. The CPL content had a strong influence on water uptake, as well as on the cumulative release of diclofenac sodium (DS) and indomethacin (IDM). It was demonstrated that the drug delivery preferentially takes place in phosphate buffer saline (pH 7.4) in comparison to simulated gastric fluid (pH 1.2), where only a reduced drug release was observed. The drug release mechanism dominating these systems is described as a pseudo-Fickian diffusion, but it changes to non-Fickian release when 33wt.% of CPL was entrapped into the CS matrix or when IDM was loaded into biocomposites.

  3. Merging By Decentralized Eventual Consistency Algorithms

    Ahmed-Nacer Mehdi


    Full Text Available Merging mechanism is an essential operation for version control systems. When each member of collaborative development works on an individual copy of the project, software merging allows to reconcile modifications made concurrently as well as managing software change through branching. The collaborative system is in charge to propose a merge result that includes user’s modifications. Theusers now have to check and adapt this result. The adaptation should be as effort-less as possible, otherwise, the users may get frustrated and will quit the collaboration. This paper aims to reduce the conflicts during the collaboration and im prove the productivity. It has three objectives: study the users’ behavior during the collaboration, evaluate the quality of textual merging results produced by specific algorithms and propose a solution to improve the r esult quality produced by the default merge tool of distributed version control systems. Through a study of eight open-source repositories totaling more than 3 million lines of code, we observe the behavior of the concurrent modifications during t he merge p rocedure. We i dentified when th e ex isting merge techniques under-perform, and we propose solutions to improve the quality of the merge. We finally compare with the traditional merge tool through a large corpus of collaborative editing.

  4. Dynamic release process of pollutants during suspended sediment transport in aquatic system

    朱红伟; 王道增; 程鹏达


    Pollutants release is highly consistent with suspended sediment concentration (SSC) in water column, especially during re-suspension and transport events. The present research focuses on pollutant dynamic release from re-suspended sediment, especially the vertical distribution relationship between them. The sediment erosion experiments on a series of uniform flow are conducted in a circulate flume. Reactive tracer (phosphorus) is used as the contaminant in fine-grained sediments to identify the release characteristic length and time. Experimental results show that the flow condition near-bed depends on the sediment surface roughness. The region with high turbulent intensities corresponds to a high concentration sediment layer. In addition, the SSC decreases with the distance, water depth, and particle grain size. The sediment in a smaller grain size takes much more time to reach equilibrium concentration. Total phosphorus (TP) concentration changes along the water depth as SSC in the initial re-suspension stage, appearing in two obvi-ous concentration regimes: the upper low-concentration layer and the high-concentration near-bottom layer. This layered phenomenon remains for about 3 hours until SSC distri-bution tends to be uniform. Longitudinal desorption plays an important role in long-way transport to reduce the amount of suspended sediment in water column.

  5. Modeling controlled nutrient release from a population of polymer coated fertilizers: statistically based model for diffusion release.

    Shaviv, Avi; Raban, Smadar; Zaidel, Elina


    A statistically based model for describing the release from a population of polymer coated controlled release fertilizer (CRF) granules by the diffusion mechanism was constructed. The model is based on a mathematical-mechanistic description of the release from a single granule of a coated CRF accounting for its complex and nonlinear nature. The large variation within populations of coated CRFs poses the need for a statistically based approach to integrate over the release from the individual granules within a given population for which the distribution and range of granule radii and coating thickness are known. The model was constructed and verified using experimentally determined parameters and release curves of polymer-coated CRFs. A sensitivity analysis indicated the importance of water permeability in controlling the lag period and that of solute permeability in governing the rate of linear release and the total duration of the release. Increasing the mean values of normally distributed granule radii or coating thickness, increases the lag period and the period of linear release. The variation of radii and coating thickness, within realistic ranges, affects the release only when the standard deviation is very large or when water permeability is reduced without affecting solute permeability. The model provides an effective tool for designing and improving agronomic and environmental effectiveness of polymer-coated CRFs.

  6. 减量控释氮肥对大棚甜椒产量及土壤硝态氮、铵态氮分布的影响%Effect of Reduced Controlled Release Nitrogen Fertilizer on the Sweet Pepper Yield and Distribution of Soil Nitrate,Ammonium Nitrogen

    彭强; 李絮花; 王克安; 吕晓慧; 杨宁; 刘旭凤


    采用田间试验方法研究不同控释氮肥施用量对大棚甜椒生长及硝态氮、铵态氮含量分布的影响。结果表明,控释氮肥处理对大棚甜椒的产量、肥料利用率、氮肥农学效率、氮肥偏生产力较常规施肥有不同程度的提高,以RF30处理最佳。各施肥处理均显著增加了土壤全氮、甜椒Vc、可溶性糖、硝酸盐的含量,降低了可滴定酸的含量。施肥处理显著增加了0-60cm土层硝态氮含量,满足了甜椒在不同时期对氮素的需求。控释氮肥处理0-60cm土层铵态氮含量差异不大,常规施肥铵态氮含量明显下降。综合考虑在农民习惯性施肥基础上施用70%控释氮肥可以保证较高的产量和较好的果实品质。%Field experiment was carried out on the growth of greenhouse sweet pepper and distribution of ammonium,nitrate nitrogen content in different controlled-release nitrogen fertilizer.The results showed that in controlled-release nitrogen fertilizer treatment,the greenhouse sweet pepper yield,fertilizer utilization efficiency,nitrogen agronomic efficiency and nitrogen partial productivity were higher than the conventional fertilization increased to different extent,and the best treatment was RF30.The fertilizer treatment significantly increased the total nitrogen,pepper Vc,soluble sugar,and nitrate content,decreased titratable acid content.The fertilization treatments significantly increased the content of nitrate nitrogen in soil layer 0-60 cm,meeting the nitrogen demand in the different stages of the sweet pepper.With controlled release nitrogen fertilizer treatments,ammonium nitrogen content in soil layer 0-60 cm were not significant,but with conventional fertilizer treatments,ammonium nitrogen concentration decreased significantly.Considering farmer habitual fertilization,70% controlled-release nitrogen fertilizer can ensure higher yield and better quality of sweet pepper.

  7. The illustris simulation: Public data release

    Nelson, D.; Pillepich, A.; Genel, S.; Vogelsberger, M.; Springel, V.; Torrey, P.; Rodriguez-Gomez, V.; Sijacki, D.; Snyder, G. F.; Griffen, B.; Marinacci, F.; Blecha, L.; Sales, L.; Xu, D.; Hernquist, L.


    We present the full public release of all data from the Illustris simulation project. Illustris is a suite of large volume, cosmological hydrodynamical simulations run with the moving-mesh code AREPO and including a comprehensive set of physical models critical for following the formation and evolution of galaxies across cosmic time. Each simulates a volume of (106.5 Mpc)3 and self-consistently evolves five different types of resolution elements from a starting redshift of z = 127 to the present day, z = 0. These components are: dark matter particles, gas cells, passive gas tracers, stars and stellar wind particles, and supermassive black holes. This data release includes the snapshots at all 136 available redshifts, halo and subhalo catalogs at each snapshot, and two distinct merger trees. Six primary realizations of the Illustris volume are released, including the flagship Illustris-1 run. These include three resolution levels with the fiducial "full" baryonic physics model, and a dark matter only analog for each. In addition, we provide four distinct, high time resolution, smaller volume "subboxes". The total data volume is ∼265 TB, including ∼800 full volume snapshots and ∼30,000 subbox snapshots. We describe the released data products as well as tools we have developed for their analysis. All data may be directly downloaded in its native HDF5 format. Additionally, we release a comprehensive, web-based API which allows programmatic access to search and data processing tasks. In both cases we provide example scripts and a getting-started guide in several languages: currently, IDL, Python, and Matlab. This paper addresses scientific issues relevant for the interpretation of the simulations, serves as a pointer to published and on-line documentation of the project, describes planned future additional data releases, and discusses technical aspects of the release.

  8. Helium release from radioisotope heat sources

    Peterson, D.E.; Early, J.W.; Starzynski, J.S.; Land, C.C.


    Diffusion of helium in /sup 238/PuO/sub 2/ fuel was characterized as a function of the heating rate and the fuel microstructure. The samples were thermally ramped in an induction furnace and the helium release rates measured with an automated mass spectrometer. The diffusion constants and activation energies were obtained from the data using a simple diffusion model. The release rates of helium were correlated with the fuel microstructure by metallographic examination of fuel samples. The release mechanism consists of four regimes, which are dependent upon the temperature. Initially, the release is controlled by movement of point defects combined with trapping along grain boundaries. This regime is followed by a process dominated by formation and growth of helium bubbles along grain boundaries. The third regime involves volume diffusion controlled by movement of oxygen vacancies. Finally, the release at the highest temperatures follows the diffusion rate of intragranular bubbles. The tendency for helium to be trapped within the grain boundaries diminishes with small grain sizes, slow thermal pulses, and older fuel.

  9. Consistent lattice Boltzmann equations for phase transitions.

    Siebert, D N; Philippi, P C; Mattila, K K


    Unlike conventional computational fluid dynamics methods, the lattice Boltzmann method (LBM) describes the dynamic behavior of fluids in a mesoscopic scale based on discrete forms of kinetic equations. In this scale, complex macroscopic phenomena like the formation and collapse of interfaces can be naturally described as related to source terms incorporated into the kinetic equations. In this context, a novel athermal lattice Boltzmann scheme for the simulation of phase transition is proposed. The continuous kinetic model obtained from the Liouville equation using the mean-field interaction force approach is shown to be consistent with diffuse interface model using the Helmholtz free energy. Density profiles, interface thickness, and surface tension are analytically derived for a plane liquid-vapor interface. A discrete form of the kinetic equation is then obtained by applying the quadrature method based on prescribed abscissas together with a third-order scheme for the discretization of the streaming or advection term in the Boltzmann equation. Spatial derivatives in the source terms are approximated with high-order schemes. The numerical validation of the method is performed by measuring the speed of sound as well as by retrieving the coexistence curve and the interface density profiles. The appearance of spurious currents near the interface is investigated. The simulations are performed with the equations of state of Van der Waals, Redlich-Kwong, Redlich-Kwong-Soave, Peng-Robinson, and Carnahan-Starling.

  10. Exploring the Consistent behavior of Information Services

    Kapidakis Sarantos


    Full Text Available Computer services are normally assumed to work well all the time. This usually happens for crucial services like bank electronic services, but not necessarily so for others, that there is no commercial interest in their operation. In this work we examined the operation and the errors of information services and tried to find clues that will help predicting the consistency of the behavior and the quality of the harvesting, which is harder because of the transient conditions and the many services and the huge amount of harvested information. We found many unexpected situations. The services that always successfully satisfy a request may in fact return part of it. A significant part of the OAI services have ceased working while many other serves occasionally fail to respond. Some services fail in the same way each time, and we pronounce them dead, as we do not see a way to overcome that. Others also always, or sometimes fail, but not in the same way, and we hope that their behavior is affected by temporary factors, that may improve later on. We categorized the services into classes, to study their behavior in more detail.

  11. Consistent quadrupole-octupole collective model

    Dobrowolski, A.; Mazurek, K.; Góźdź, A.


    Within this work we present a consistent approach to quadrupole-octupole collective vibrations coupled with the rotational motion. A realistic collective Hamiltonian with variable mass-parameter tensor and potential obtained through the macroscopic-microscopic Strutinsky-like method with particle-number-projected BCS (Bardeen-Cooper-Schrieffer) approach in full vibrational and rotational, nine-dimensional collective space is diagonalized in the basis of projected harmonic oscillator eigensolutions. This orthogonal basis of zero-, one-, two-, and three-phonon oscillator-like functions in vibrational part, coupled with the corresponding Wigner function is, in addition, symmetrized with respect to the so-called symmetrization group, appropriate to the collective space of the model. In the present model it is D4 group acting in the body-fixed frame. This symmetrization procedure is applied in order to provide the uniqueness of the Hamiltonian eigensolutions with respect to the laboratory coordinate system. The symmetrization is obtained using the projection onto the irreducible representation technique. The model generates the quadrupole ground-state spectrum as well as the lowest negative-parity spectrum in 156Gd nucleus. The interband and intraband B (E 1 ) and B (E 2 ) reduced transition probabilities are also calculated within those bands and compared with the recent experimental results for this nucleus. Such a collective approach is helpful in searching for the fingerprints of the possible high-rank symmetries (e.g., octahedral and tetrahedral) in nuclear collective bands.

  12. A Consistent Phylogenetic Backbone for the Fungi

    Ebersberger, Ingo; de Matos Simoes, Ricardo; Kupczok, Anne; Gube, Matthias; Kothe, Erika; Voigt, Kerstin; von Haeseler, Arndt


    The kingdom of fungi provides model organisms for biotechnology, cell biology, genetics, and life sciences in general. Only when their phylogenetic relationships are stably resolved, can individual results from fungal research be integrated into a holistic picture of biology. However, and despite recent progress, many deep relationships within the fungi remain unclear. Here, we present the first phylogenomic study of an entire eukaryotic kingdom that uses a consistency criterion to strengthen phylogenetic conclusions. We reason that branches (splits) recovered with independent data and different tree reconstruction methods are likely to reflect true evolutionary relationships. Two complementary phylogenomic data sets based on 99 fungal genomes and 109 fungal expressed sequence tag (EST) sets analyzed with four different tree reconstruction methods shed light from different angles on the fungal tree of life. Eleven additional data sets address specifically the phylogenetic position of Blastocladiomycota, Ustilaginomycotina, and Dothideomycetes, respectively. The combined evidence from the resulting trees supports the deep-level stability of the fungal groups toward a comprehensive natural system of the fungi. In addition, our analysis reveals methodologically interesting aspects. Enrichment for EST encoded data—a common practice in phylogenomic analyses—introduces a strong bias toward slowly evolving and functionally correlated genes. Consequently, the generalization of phylogenomic data sets as collections of randomly selected genes cannot be taken for granted. A thorough characterization of the data to assess possible influences on the tree reconstruction should therefore become a standard in phylogenomic analyses. PMID:22114356

  13. Volume Haptics with Topology-Consistent Isosurfaces.

    Corenthy, Loc; Otaduy, Miguel A; Pastor, Luis; Garcia, Marcos


    Haptic interfaces offer an intuitive way to interact with and manipulate 3D datasets, and may simplify the interpretation of visual information. This work proposes an algorithm to provide haptic feedback directly from volumetric datasets, as an aid to regular visualization. The haptic rendering algorithm lets users perceive isosurfaces in volumetric datasets, and it relies on several design features that ensure a robust and efficient rendering. A marching tetrahedra approach enables the dynamic extraction of a piecewise linear continuous isosurface. Robustness is achieved using a continuous collision detection step coupled with state-of-the-art proxy-based rendering methods over the extracted isosurface. The introduced marching tetrahedra approach guarantees that the extracted isosurface will match the topology of an equivalent isosurface computed using trilinear interpolation. The proposed haptic rendering algorithm improves the consistency between haptic and visual cues computing a second proxy on the isosurface displayed on screen. Our experiments demonstrate the improvements on the isosurface extraction stage as well as the robustness and the efficiency of the complete algorithm.

  14. Consistency between GRUAN sondes, LBLRTM and IASI

    X. Calbet


    Full Text Available Radiosonde soundings from the GCOS Reference Upper-Air Network (GRUAN data record are shown to be consistent with Infrared Atmospheric Sounding Instrument (IASI-measured radiances via LBLRTM (Line-By-Line Radiative Transfer Model in the part of the spectrum that is mostly affected by water vapour absorption in the upper troposphere (from 700 hPa up. This result is key for climate data records, since GRUAN, IASI and LBLRTM constitute reference measurements or a reference radiative transfer model in each of their fields. This is specially the case for night-time radiosonde measurements. Although the sample size is small (16 cases, daytime GRUAN radiosonde measurements seem to have a small dry bias of 2.5 % in absolute terms of relative humidity, located mainly in the upper troposphere, with respect to LBLRTM and IASI. Full metrological closure is not yet possible and will not be until collocation uncertainties are better characterized and a full uncertainty covariance matrix is clarified for GRUAN.

  15. Retrocausation, Consistency, and the Bilking Paradox

    Dobyns, York H.


    Retrocausation seems to admit of time paradoxes in which events prevent themselves from occurring and thereby create a physical instance of the liar's paradox, an event which occurs iff it does not occur. The specific version in which a retrocausal event is used to trigger an intervention which prevents its own future cause is called the bilking paradox (the event is bilked of its cause). The analysis of Echeverria, Klinkhammer, and Thorne (EKT) suggests time paradoxes cannot arise even in the presence of retrocausation. Any self-contradictory event sequence will be replaced in reality by a closely related but noncontradictory sequence. The EKT analysis implies that attempts to create bilking must instead produce logically consistent sequences wherein the bilked event arises from alternative causes. Bilking a retrocausal information channel of limited reliability usually results only in failures of signaling. An exception applies when the bilking is conducted in response only to some of the signal values that can be carried on the channel. Theoretical analysis based on EKT predicts that, since some of the channel outcomes are not bilked, the channel is capable of transmitting data with its normal reliability, and the paradox-avoidance effects will instead suppress the outcomes that would lead to forbidden (bilked) transmissions. A recent parapsychological experiment by Bem displays a retrocausal information channel of sufficient reliability to test this theoretical model of physical reality's response to retrocausal effects. A modified version with partial bilking would provide a direct test of the generality of the EKT mechanism.

  16. Ciliate communities consistently associated with coral diseases

    Sweet, M. J.; Séré, M. G.


    Incidences of coral disease are increasing. Most studies which focus on diseases in these organisms routinely assess variations in bacterial associates. However, other microorganism groups such as viruses, fungi and protozoa are only recently starting to receive attention. This study aimed at assessing the diversity of ciliates associated with coral diseases over a wide geographical range. Here we show that a wide variety of ciliates are associated with all nine coral diseases assessed. Many of these ciliates such as Trochilia petrani and Glauconema trihymene feed on the bacteria which are likely colonizing the bare skeleton exposed by the advancing disease lesion or the necrotic tissue itself. Others such as Pseudokeronopsis and Licnophora macfarlandi are common predators of other protozoans and will be attracted by the increase in other ciliate species to the lesion interface. However, a few ciliate species (namely Varistrombidium kielum, Philaster lucinda, Philaster guamense, a Euplotes sp., a Trachelotractus sp. and a Condylostoma sp.) appear to harbor symbiotic algae, potentially from the coral themselves, a result which may indicate that they play some role in the disease pathology at the very least. Although, from this study alone we are not able to discern what roles any of these ciliates play in disease causation, the consistent presence of such communities with disease lesion interfaces warrants further investigation.

  17. Mechanisms of HSP72 release

    Alexzander Asea


    Currently two mechanisms are recognized by which heat shock proteins (HSP) are released from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma, surgery and following infection with lytic viruses, and an active release mechanism which involves the non classical protein release pathway. HSPs are released both as free HSP and within exosomes. This review covers recent findings on the mechanism by which stress induces the release of HSP72 into the circulation and the biological significance of circulating HSP72 to host defense against disease.

  18. Triggered Release from Polymer Capsules

    Esser-Kahn, Aaron P. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry; Odom, Susan A. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry; Sottos, Nancy R. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Materials Science and Engineering; White, Scott R. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Aerospace Engineering; Moore, Jeffrey S. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry


    Stimuli-responsive capsules are of interest in drug delivery, fragrance release, food preservation, and self-healing materials. Many methods are used to trigger the release of encapsulated contents. Here we highlight mechanisms for the controlled release of encapsulated cargo that utilize chemical reactions occurring in solid polymeric shell walls. Triggering mechanisms responsible for covalent bond cleavage that result in the release of capsule contents include chemical, biological, light, thermal, magnetic, and electrical stimuli. We present methods for encapsulation and release, triggering methods, and mechanisms and conclude with our opinions on interesting obstacles for chemically induced activation with relevance for controlled release.

  19. Protecting privacy in data release

    Livraga, Giovanni


    This book presents a comprehensive approach to protecting sensitive information when large data collections are released by their owners. It addresses three key requirements of data privacy: the protection of data explicitly released, the protection of information not explicitly released but potentially vulnerable due to a release of other data, and the enforcement of owner-defined access restrictions to the released data. It is also the first book with a complete examination of how to enforce dynamic read and write access authorizations on released data, applicable to the emerging data outsou

  20. Improving electrofishing catch consistency by standardizing power

    Burkhardt, Randy W.; Gutreuter, Steve


    The electrical output of electrofishing equipment is commonly standardized by using either constant voltage or constant amperage, However, simplified circuit and wave theories of electricity suggest that standardization of power (wattage) available for transfer from water to fish may be critical for effective standardization of electrofishing. Electrofishing with standardized power ensures that constant power is transferable to fish regardless of water conditions. The in situ performance of standardized power output is poorly known. We used data collected by the interagency Long Term Resource Monitoring Program (LTRMP) in the upper Mississippi River system to assess the effectiveness of standardizing power output. The data consisted of 278 electrofishing collections, comprising 9,282 fishes in eight species groups, obtained during 1990 from main channel border, backwater, and tailwater aquatic areas in four reaches of the upper Mississippi River and one reach of the Illinois River. Variation in power output explained an average of 14.9% of catch variance for night electrofishing and 12.1 % for day electrofishing. Three patterns in catch per unit effort were observed for different species: increasing catch with increasing power, decreasing catch with increasing power, and no power-related pattern. Therefore, in addition to reducing catch variation, controlling power output may provide some capability to select particular species. The LTRMP adopted standardized power output beginning in 1991; standardized power output is adjusted for variation in water conductivity and water temperature by reference to a simple chart. Our data suggest that by standardizing electrofishing power output, the LTRMP has eliminated substantial amounts of catch variation at virtually no additional cost.

  1. Effect of Controlled-release Urea Combined with Common Urea on the Grain Yields of Summer Maize and Distribution of Soil Ammonium and Nitrate Content%控释掺混肥对夏玉米产量及土壤硝态氮和铵态氮分布的影响

    李伟; 李絮花; 唐慎欣; 李海燕; 刘旭凤; 彭强


    通过田间试验研究释放期60 d的水基包膜尿素与普通尿素常规施肥用量下不同比例配合追施对夏玉米产量、肥料利用率、氮肥农学利用率、氮肥偏生产力、氮素收获指数、氮素积累量及0-60 cm土壤硝铵态氦含量动态分布的影响.结果表明:各控释掺混处理对夏玉米的产量、肥料利用率、氮肥农学利用率、氮肥偏生产力及氮素收获指数较常规施肥都有不同程度的提高,以控氮比50%处理最佳,产量和氮肥利用率分别比对照的提高9.43%和24.69%,达到显著水平;各控释掺混处理0-60 cm土壤都保持较高的硝态氮含量,至后期较常规施肥的略高,满足了玉米的生长.玉米各时期土壤铵态氮含量大致以高控氮比处理的含量高,差异不明显,但显著高于常规施肥处理的.控氮比50%处理更适合本区域玉米生产.%Field experiment were carried out on grain yield of summer maize to determine the effect of different proportions of water-base controlled-release coated urea of 60 d release duration combined with conventional urea as topdressing on nitrogen utilization, nitrogen agronomic efficiency, nitrogen partial productivity, nitrogen harvest index and nitrogen accumulation. Dynamic distribution of nitrate content in soil was also studied. The findings indicated that the treatment of controlled-release urea combined with conventional urea (CRUCU)was remarkably higher than the ones used urea alone in various degree in maize yield, fertilizer utilization, nitrogen agronomic efficiency, productivity and nitrogen partial nitrogen harvest index, and the treatment used 50% controlled-release coated urea was superior to other ones. Its yield was increased by 9. 43% than the treatment used urea alone, while nitrogen utilization was 24. 69%. Both differences reached significant level. The nitrate nitrogen content of treatment of CRUCU was sufficient in 0 - 60 cm depth in soil layer throughout the later growth

  2. Dynamic self-consistent field theory for unentangled homopolymer fluids

    Mihajlovic, Maja; Lo, Tak Shing; Shnidman, Yitzhak


    We present a lattice formulation of a dynamic self-consistent field (DSCF) theory that is capable of resolving interfacial structure, dynamics, and rheology in inhomogeneous, compressible melts and blends of unentangled homopolymer chains. The joint probability distribution of all the Kuhn segments in the fluid, interacting with adjacent segments and walls, is approximated by a product of one-body probabilities for free segments interacting solely with an external potential field that is determined self-consistently. The effect of flow on ideal chain conformations is modeled with finitely extensible, nonlinearly elastic dumbbells in the Peterlin approximation, and related to stepping probabilities in a random walk. Free segment and stepping probabilities generate statistical weights for chain conformations in a self-consistent field, and determine local volume fractions of chain segments. Flux balance across unit lattice cells yields mean field transport equations for the evolution of free segment probabilities and of momentum densities on the Kuhn length scale. Diffusive and viscous contributions to the fluxes arise from segmental hops modeled as a Markov process, with transition rates reflecting changes in segmental interaction, kinetic energy, and entropic contributions to the free energy under flow. We apply the DSCF equations to study both transient and steady-state interfacial structure, flow, and rheology in a sheared planar channel containing either a one-component melt or a phase-separated, two-component blend.

  3. Post-release monitoring of Antillean manatees: an assessment of the Brazilian rehabilitation and release programme

    Normande, Iran C.; Malhado, Ana C. M.; Reid, James P.; Viana Junior, P.C.; Savaget, P. V. S.; Correia, R. A.; Luna, F. O.; R. J. Ladle,


    Mammalian reintroduction programmes frequently aim to reconnect isolated sub-populations and restore population viability. However, these long-term objectives are rarely evaluated due to the inadequacy of post-release monitoring. Here, we report the results of a unique long term telemetry-based monitoring programme for rehabilitated Antillean manatees (Trichechus manatus manatus) reintroduced into selected sites in northeast Brazil with the aim of reconnecting isolated relict populations. Twenty-one satellite-tagged rehabilitated manatees, 13 males and 8 females, were released into the wild from two sites between November 2008 and June 2013. Individual accumulation curves were plotted and home ranges were calculated through the fixed kernel method using 95% of the utilization distribution. The number and size of the Centres of Activity (COAs) were calculated using 50% of the utilization distribution. Manatees displayed a dichotomous pattern of movement, with individuals either characterized by sedentary habits or by much more extensive movements. Moreover, home range size was not significantly influenced by gender, age at release or release site. COAs were strongly associated with sheltered conditions within reefs and estuaries, and also by the presence of freshwater and feeding sites. Our data confirm that manatee reintroductions in Brazil have the potential to reconnect distant sub-populations. However, pre-release identification of potential long-distance migrants is currently unfeasible, and further analysis would be required to confirm genetic mixing of distant sub-populations.

  4. Evaluation of a soil incubation method to characterize nitrogen release patterns of slow- and controlled-release fertilizers.

    Medina, L Carolina; Sartain, Jerry B; Obreza, Thomas A; Hall, William L; Thiex, Nancy J


    Several technologies have been proposed to characterize the nutrient release patterns of slow-release fertilizers (SRF) and controlled-release fertilizers (CRF) during the last few decades. These technologies have been developed mainly by manufacturers, and are product-specific, based on the regulation and analysis of each SRF and CRF product. Despite previous efforts to characterize SRF and CRF materials, no standardized, validated method exists to assess their nutrient release patterns. However, the increased production and distribution of these materials in specialty and nonspecialty markets requires an appropriate method to verify product claims and material performance. A soil incubation column leaching procedure was evaluated to determine its suitability as a standard method to estimate nitrogen (N) release patterns of SRFs and CRFs during 180 days. The influence of three soil/sand ratios, three incubation temperatures, and four soils on method behavior was assessed using five SRFs and three CRFs. In general, the highest soil/sand ratio increased the N release rate of all materials, but this effect was more marked for the SRFs. Temperature had the greatest influence on N release rates. For CRFs, the initial N release rates and the percentage N released/day increased as temperature increased. For SRFs, raising the temperature from 25 to 35 degreesC increased initial N release rate and the total cumulative N released, and almost doubled the percentage released/day. The percentage N released/day from all products generally increased as the texture of the soil changed from sandy to loamy (lowa>California>Pennsylvania>Florida). The soil incubation technique was demonstrated to be robust and reliable for characterizing N release patterns from SRFs and CRFs. The method was reproducible, and variations in soil/sand ratio, temperature, and soil had little effect on the results.

  5. Allegheny County Toxics Release Inventory

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — The Toxics Release Inventory (TRI) data provides information about toxic substances released into the environment or managed through recycling, energy recovery, and...

  6. Heat release mechanism of energetics

    Kubota, N. [Third Research Center, Technical Research and development Institute (Japan)


    Determination of the heat release mechanism of energetic materials is a major subject of combustion study. In order to elucidate the combustion process of various types of energetic materials a generalized combustion wave structure was proposed and the heat release process was discussed. The heat release process was significantly different between the physical structures of the materials: homogeneous and heterogeneous materials. The thermal structure of an azide polymer was evaluated to demonstrate the heat release mechanism. (author) 6 refs.

  7. Optimization of propranolol HCl release kinetics from press coated sustained release tablets.

    Ali, Adel Ahmed; Ali, Ahmed Mahmoud


    Press-coated sustained release tablets offer a valuable, cheap and easy manufacture alternative to the highly expensive, multi-step manufacture and filling of coated beads. In this study, propranolol HCl press-coated tablets were prepared using hydroxylpropylmethylcellulose (HPMC) as tablet coating material together with carbopol 971P and compressol as release modifiers. The prepared formulations were optimized for zero-order release using artificial neural network program (INForm, Intelligensys Ltd, North Yorkshire, UK). Typical zero-order release kinetics with extended release profile for more than 12 h was obtained. The most important variables considered by the program in optimizing formulations were type and proportion of polymer mixture in the coat layer and distribution ratio of drug between core and coat. The key elements found were; incorporation of 31-38 % of the drug in the coat, fixing the amount of polymer in coat to be not less than 50 % of coat layer. Optimum zero-order release kinetics (linear regression r2 = 0.997 and Peppas model n value > 0.80) were obtained when 2.5-10 % carbopol and 25-42.5% compressol were incorporated into the 50 % HPMC coat layer.

  8. 5-Fluorouracil Encapsulated Chitosan Nanoparticles for pH-Stimulated Drug Delivery: Evaluation of Controlled Release Kinetics

    R. Seda Tığlı Aydın


    Full Text Available Nanoparticles consisting of human therapeutic drugs are suggested as a promising strategy for targeted and localized drug delivery to tumor cells. In this study, 5-fluorouracil (5-FU encapsulated chitosan nanoparticles were prepared in order to investigate potentials of localized drug delivery for tumor environment due to pH sensitivity of chitosan nanoparticles. Optimization of chitosan and 5-FU encapsulated nanoparticles production revealed 148.8±1.1 nm and 243.1±17.9 nm particle size diameters with narrow size distributions, which are confirmed by scanning electron microscope (SEM images. The challenge was to investigate drug delivery of 5-FU encapsulated chitosan nanoparticles due to varied pH changes. To achieve this objective, pH sensitivity of prepared chitosan nanoparticle was evaluated and results showed a significant swelling response for pH 5 with particle diameter of ∼450 nm. In vitro release studies indicated a controlled and sustained release of 5-FU from chitosan nanoparticles with the release amounts of 29.1–60.8% due to varied pH environments after 408 h of the incubation period. pH sensitivity is confirmed by mathematical modeling of release kinetics since chitosan nanoparticles showed stimuli-induced release. Results suggested that 5-FU encapsulated chitosan nanoparticles can be launched as pH-responsive smart drug delivery agents for possible applications of cancer treatments.

  9. Structural Consistency: Enabling XML Keyword Search to Eliminate Spurious Results Consistently

    Lee, Ki-Hoon; Han, Wook-Shin; Kim, Min-Soo


    XML keyword search is a user-friendly way to query XML data using only keywords. In XML keyword search, to achieve high precision without sacrificing recall, it is important to remove spurious results not intended by the user. Efforts to eliminate spurious results have enjoyed some success by using the concepts of LCA or its variants, SLCA and MLCA. However, existing methods still could find many spurious results. The fundamental cause for the occurrence of spurious results is that the existing methods try to eliminate spurious results locally without global examination of all the query results and, accordingly, some spurious results are not consistently eliminated. In this paper, we propose a novel keyword search method that removes spurious results consistently by exploiting the new concept of structural consistency.

  10. Is bioexsiccation releasing dioxins?

    Benfenati, E.; Mariani, G.; Lodi, M.; Reitano, G.; Fanelli, R. [' ' Mario Negri' ' Institute for Pharmacological Research, Milan (Italy)


    Bioexsiccation is a relatively new process to treat urban solid wastes. We studied the possible release of dioxins from this process, measuring dioxin concentration in the emissions from a bioexsiccation plant. As a comparison, we measured atmospheric levels nearby the plant. The biofilter treating gaseous emissions was also evaluated to assess its efficiency. Dioxin concentrations in the biofilter effluent were lower than both those before the biofilter and the nearby atmosphere. In the last years the management and treatment of solid urban wastes produced some improved processes, in a general attempt to cope with the problem of the huge amount of wastes produced by the modern society. Bio-exsiccation of waste aims at affording a much more biologically inert and manageable material compared to the original waste. In this process the urban solid waste is kept under an air stream for about two weeks. The waste undergoes biological transformation, due to fermentation, which produces an increase of the temperature up to 60-70 C. At the end of the process the weight waste is typically reduced by one third, due to the loss of water and to the degradation of putrescible compounds. Since this is a relatively new industrial process, we studied the possible release of dioxins in the atmospheric emissions of the bioexsiccation plant.

  11. Interannual consistency in fractal snow depth patterns at two Colorado mountain sites

    Jeffrey S. Deems; Steven R. Fassnacht; Kelly J. Elder


    Fractal dimensions derived from log-log variograms are useful for characterizing spatial structure and scaling behavior in snow depth distributions. This study examines the temporal consistency of snow depth scaling features at two sites using snow depth distributions derived from lidar datasets collected in 2003 and 2005. The temporal snow accumulation patterns in...

  12. Consistência do padrão de agrupamento de cultivares de milho Clustering pattern consistency of corn cultivars

    Alberto Cargnelutti Filho


    variables, were simulated under the standard normal distribution, 1,000 experiments for each of the 54 scenarios formed by the combination among the number of cultivars (20, 30, 40, 50, 60, 70, 80, 90 and 100 and the number of variables (5, 6, 7, 8, 9 and 10. Analyses of correlation, diagnoses of multicollinearity ans cluster were carried out. Clustering pattern consistency was evaluated by the cophenetic correlation coefficient. There is a decrease of clustering pattern consistency with the increase in the number of cultivars and variable. The euclidean distance provides greater clustering pattern consistency in relation to Manhattan distance. The clustering pattern consistency among the methods increases as follows: Ward's, complete linkage, single linkage and average linkage between groups.


    王旭东; 王迎军; 魏坤; 赵娜如; 张淑花


    采用单乳化溶剂挥发法制备了聚己内酯[poly(ε-caprolactone),PCL]/纳米羟基磷灰石(nano-hydroxyapatite,n-HA)复合微球.使用两种具有不同水溶性的模型药物对硝摹苯胺(p-nitroaniline)和罗丹明B(RhodamineB,RhB),研究n-HA在复合微球中的作用.用扫描电子显微镜观察微球的表面形貌.通过紫外-可见光分光光度法计算药物载量和包封率.用共聚焦激光显微镜分析药物在微球中的分布.分别研究了PCL微球和PCL/HA复合微球的体外释放性质.复合微球可以持续释放药物4周以上,在前3 d的突释后,其释放曲线符合Higuchi扩散方程.n-HA的加入使较亲水药物RhB在复合微球中分布更均匀,对较疏水药物对硝基苯胺则影响不明显.n-HA减少了载亲水药物的复合微球在前 3d 的突释,并减缓了其后的释放速率.结果表明:PCL/n-HA复合结构的材料有希望作为一种新的长效药物释放载体应用.%Poly (ε-ocaprolactone) (PCL)/hydroxyapatite nanoparticle (n-HA) composite microspheres were prepared via a single emul-sion solvent evaporation method. Two model compounds (p-nitroaniline and Rhodarnine B(RhB)) with different water solubilities were used to investigate the effect of HA nanoparticles on composite microspheres. The microspheres morphology was observed by scanning electron microscope. The drug loading and encapsulation efficiency were calculated by ultraviolet (UV) drug detection.Drug distribution within the microsphere matrix was studied by a con_focal laser scanning microscope. The in vitro drug release pro-perties of both the neat PCL and PCL/n-HA composite microspheres were investigated. After 3 d of initial burst, composite micro-spheres could sustainedly release drugs over 4 weeks, which could be explained by Higuchi's diffusion equation. The HA nanoparti-cles did not exhibit a distinct difference for p-nitroaniline-loaded microspheres, but helped RhB to be distributed more evenly. For hydrophilic

  14. Hydrogen Release Studies of Alkali Metal Amidoboranes

    Luedtke, Avery T.; Autrey, Thomas


    A series of metal amido boranes LiNH2BH3 (LAB), NaNH2BH3 (SAB), LiNH(Me)BH3 (LMAB), NaNH(Me)BH3 (SMAB), KNH(Me)BH3 (PMAB), and KNH(tBu)BH3 (PBAB) were synthesized, by solution phase methods, and the thermal release of H2 in the solid state was studied. Based on the observed trends in reaction rates of H > Me > tBu and the kinetic isotope effect, the mechanism of hydrogen release from MAB compounds was found to proceed through a bimolecular mechanism involving the intermediacy of a MH (M = Li, Na, or K). The mechanism of hydrogen release from metal amidoboranes, a metal ion assisted hydride transfer, is very different than the mechanism of hydrogen release from the parent compound ammonia borane (AB). The non-volatile products formed from MAB’s are significantly different than the products formed after hydrogen release from AB. The boron containing resulting from the release of one equivalent of hydrogen from the metal amidoboranes were characterized by MAS 11B NMR spectroscopy and found to contain both BH3 and sp2 hybridized BH groups, consistent with a general structural feature MN(R)=BHN(R)MBH3. This work was funded by the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy as part of the Chemical Hydrogen Storage CoE at Pacific Northwest National Laboratory (PNNL). PNNL is operated for the U.S. DOE by Battelle. MAS NMR studies were performed using EMSL, a national scientific user facility sponsored by the Department of Energy’s Office of Biological and Environmental Research located at PNNL.

  15. Release of monomers from composite dust.

    Cokic, S M; Duca, R C; Godderis, L; Hoet, P H; Seo, J W; Van Meerbeek, B; Van Landuyt, K L


    Dental personnel are more at risk to develop asthmatic disease, but the exact reason is so far unknown. During abrasive procedures, dental personnel are exposed to nano-sized dust particles released from dental composite. The aim of this study was to investigate whether respirable composite dust may also release monomers. Respirable (composite dust was collected and the release of methacrylate monomers and Bisphenol A (BPA) in water and ethanol was evaluated by liquid chromatography/mass spectroscopy (LC-MS/MS). The dust was ultra-morphologically and chemically analyzed by transmission electron microscopy and energy-dispersive X-ray spectroscopy (TEM-EDS). LC-MS/MS analysis revealed that, irrespective of the type of composite, the respirable fraction of composite dust may release relatively high concentrations of unpolymerized methacrylate monomers, both in water and ethanol. Higher release was observed in ethanol. The endocrine disruptor BPA also emanated from the composite dust particles. TEM showed that most particles were nano-sized, although particle size ranged between 6nm and 5μm with a mode value between 12 and 39nm. Most particles consisted of several filler particles in resin matrix, although single nano-filler particles could also be observed. Elemental analysis by TEM-EDS proved that the particles collected on the filters originated from the dental composites. Theoretically, composite dust may function as a vehicle to transport monomers deeply into the respiratory system. The results of this study may shed another light on the increasing incidence of respiratory disease among dental personnel, and more care should be taken to prevent inhalation of composite dust. Special care should be taken to prevent inhalation of composite dust, as the dust particles may release methacrylate monomers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Self-Consistent Description of Nitrogen dc Glow Discharge

    傅广生; 王久丽; 于威; 韩理


    A self-consistent hybrid Monte Carlo fluid model is presented to describe the nitrogen dc glow discharge. The movement of fast electrons is simulated by the Monte Carlo method while the dynamics of slow electrons and ions is by fluid equations. The spatial features of the charged species and the corresponding electric field throughout the discharge have been calculated, which include the creation rates of ions and slow electrons, densities of the charged species, the electric field and the potential distribution. These closely related results can give a selfconsistent explanation of the discharge characteristics throughout the space of nitrogen dc glow discharge. The calculated ion density is also compared with the corresponding experimental result.

  17. Multirobot FastSLAM Algorithm Based on Landmark Consistency Correction

    Shi-Ming Chen


    Full Text Available Considering the influence of uncertain map information on multirobot SLAM problem, a multirobot FastSLAM algorithm based on landmark consistency correction is proposed. Firstly, electromagnetism-like mechanism is introduced to the resampling procedure in single-robot FastSLAM, where we assume that each sampling particle is looked at as a charged electron and attraction-repulsion mechanism in electromagnetism field is used to simulate interactive force between the particles to improve the distribution of particles. Secondly, when multiple robots observe the same landmarks, every robot is regarded as one node and Kalman-Consensus Filter is proposed to update landmark information, which further improves the accuracy of localization and mapping. Finally, the simulation results show that the algorithm is suitable and effective.

  18. Finding consistent gene transmission patterns on large and complex pedigrees.

    Pirinen, Matti; Gasbarra, Dario


    A heuristic algorithm for finding gene transmission patterns on large and complex pedigrees with partially observed genotype data is proposed. The method can be used to generate an initial point for a Markov chain Monte Carlo simulation or to check that the given pedigree and the genotype data are consistent. In small pedigrees, the algorithm is exact by exhaustively enumerating all possibilities, but, in large pedigrees, with a considerable amount of unknown data, only a subset of promising configurations can actually be checked. For that purpose, the configurations are ordered by combining the approximative conditional probability distribution of the unknown genotypes with the information on the relationships between individuals. We also introduce a way to divide the task into subparts, which has been shown to be useful in large pedigrees. The algorithm has been implemented in a program called APE (Allelic Path Explorer) and tested in three different settings with good results.

  19. Time-Consistent and Market-Consistent Evaluations (Revised version of 2012-086)

    Stadje, M.A.; Pelsser, A.


    Abstract: We consider evaluation methods for payoffs with an inherent financial risk as encountered for instance for portfolios held by pension funds and insurance companies. Pricing such payoffs in a way consistent to market prices typically involves combining actuarial techniques with methods from

  20. Consistency Research of Negative Electrode Pasting for MH/Ni High Power Battery

    Zhang Zhong; Liu Dong; Cao Shengbiao; Li Jianping; Jia Chunming


    It is discovered that the consistency of negative electrode is one of the main influences on battery performance, since the main raw material in negative electrode is metal hydride powder, ingredients, particle distribution and density of the powder could influence the pasting consistency in some aspects.With the study of MH powder characteristics, through the modification of the coating die, the consistency of negative electrode is improved efficiently.

  1. Assembly of bio-nanoparticles for double controlled drug release.

    Wei Huang

    Full Text Available A critical limiting factor of chemotherapy is the unacceptably high toxicity. The use of nanoparticle based drug carriers has significantly reduced the side effects and facilitated the delivery of drugs. Source of the remaining side effect includes (1 the broad final in vivo distribution of the administrated nanoparticles, and (2 strong basal drug release from nanoparticles before they could reach the tumor. Despite the advances in pH-triggered release, undesirable basal drug release has been a constant challenge under in vivo conditions. In this study, functionalized single walled carbon nanohorn supported immunoliposomes were assembled for paclitaxel delivery. The immunoliposomes were formulated with polyethylene glycol, thermal stable and pH sensitive phospholipids. Each nanohorn was found to be encapsulated within one immunoliposome. Results showed a highly pH dependent release of paclitaxel in the presence of serum at body temperature with minimal basal release under physiological conditions. Upon acidification, paclitaxel was released at a steady rate over 30 days with a cumulative release of 90% of the loaded drug. The drug release results proved our hypothesized double controlled release mechanism from the nanoparticles. Other results showed the nanoparticles have doubled loading capacity compared to that of traditional liposomes and higher affinity to breast cancer cells overexpressing Her2 receptors. Internalized nanoparticles were found in lysosomes.

  2. Attentional priming releases crowding.

    Kristjánsson, Arni; Heimisson, Pétur Rúnar; Róbertsson, Gunnar Freyr; Whitney, David


    Views of natural scenes unfold over time, and objects of interest that were present a moment ago tend to remain present. While visual crowding places a fundamental limit on object recognition in cluttered scenes, most studies of crowding have suffered from the limitation that they typically involved static scenes. The role of temporal continuity in crowding has therefore been unaddressed. We investigated intertrial effects upon crowding in visual scenes, showing that crowding is considerably diminished when objects remain constant on consecutive visual search trials. Repetition of both the target and distractors decreases the critical distance for crowding from flankers. More generally, our results show how object continuity through between-trial priming releases objects that would otherwise be unidentifiable due to crowding. Crowding, although it is a significant bottleneck on object recognition, can be mitigated by statistically likely temporal continuity of the objects. Crowding therefore depends not only on what is momentarily present, but also on what was previously attended.

  3. Consistency check of photon beam physical data after recommissioning process

    Kadman, B.; Chawapun, N.; Ua-apisitwong, S.; Asakit, T.; Chumpu, N.; Rueansri, J.


    In radiotherapy, medical linear accelerator (Linac) is the key system used for radiation treatments delivery. Although, recommissioning was recommended after major modification of the machine by AAPM TG53, but it might not be practical in radiotherapy center with heavy workloads. The main purpose of this study was to compare photon beam physical data between initial commissioning and recommissioning of 6 MV Elekta Precise linac. The parameters for comparing were the percentage depth dose (PDD) and beam profiles. The clinical commissioning test cases followed IAEA-TECDOC-1583 were planned on REF 91230 IMRT Dose Verification Phantom by Philips’ Pinnacle treatment planning system. The Delta4PT was used for dose distribution verification with 90% passing criteria of the gamma index (3%/3mm). Our results revealed that the PDDs and beam profiles agreed within a tolerance limit recommended by TRS430. Most of the point doses and dose distribution verification passed the acceptance criteria. This study showed the consistency of photon beam physical data after recommissioning process. There was a good agreement between initial commissioning and recommissioning within a tolerance limit, demonstrated that the full recommissioning process might not be required. However, in the complex treatment planning geometry, the initial data should be applied with great caution.

  4. Determining drug release rates of hydrophobic compounds from nanocarriers.

    D'Addio, Suzanne M; Bukari, Abdallah A; Dawoud, Mohammed; Bunjes, Heike; Rinaldi, Carlos; Prud'homme, Robert K


    Obtaining meaningful drug release profiles for drug formulations is essential prior to in vivo testing and for ensuring consistent quality. The release kinetics of hydrophobic drugs from nanocarriers (NCs) are not well understood because the standard protocols for maintaining sink conditions and sampling are not valid owing to mass transfer and solubility limitations. In this work, a new in vitroassay protocol based on 'lipid sinks' and magnetic separation produces release conditions that mimic the concentrations of lipid membranes and lipoproteins in vivo, facilitates separation, and thus allows determination of intrinsic release rates of drugs from NCs. The assay protocol is validated by (i) determining the magnetic separation efficiency, (ii) demonstrating that sink condition requirements are met, and (iii) accounting for drug by completing a mass balance. NCs of itraconazole and cyclosporine A (CsA) were prepared and the drug release profiles were determined. This release protocol has been used to compare the drug release from a polymer stabilized NC of CsA to a solid drug NP of CsA alone. These data have led to the finding that stabilizing block copolymer layers have a retarding effect on drug release from NCs, reducing the rate of CsA release fourfold compared with the nanoparticle without a polymer coating.This article is part of the themed issue 'Soft interfacial materials: from fundamentals to formulation'.

  5. Self consistent tight binding model for dissociable water

    Lin, You; Wynveen, Aaron; Halley, J. W.; Curtiss, L. A.; Redfern, P. C.


    We report results of development of a self consistent tight binding model for water. The model explicitly describes the electrons of the liquid self consistently, allows dissociation of the water and permits fast direct dynamics molecular dynamics calculations of the fluid properties. It is parameterized by fitting to first principles calculations on water monomers, dimers, and trimers. We report calculated radial distribution functions of the bulk liquid, a phase diagram and structure of solvated protons within the model as well as ac conductivity of a system of 96 water molecules of which one is dissociated. Structural properties and the phase diagram are in good agreement with experiment and first principles calculations. The estimated DC conductivity of a computational sample containing a dissociated water molecule was an order of magnitude larger than that reported from experiment though the calculated ratio of proton to hydroxyl contributions to the conductivity is very close to the experimental value. The conductivity results suggest a Grotthuss-like mechanism for the proton component of the conductivity.

  6. Inconsistent handers show higher psychopathy than consistent handers.

    Shobe, Elizabeth; Desimone, Kailey


    Three hundred and forty-two university students completed the Short Dark Triad (SD3) and the Edinburgh Handedness Inventory (EHI). Inconsistent handers showed higher psychopathy scores than consistent handers, and no handedness differences were observed for narcissism or Machiavellianism. Participants were further subdivided by quartile into low, moderately low, moderately high, and high psychopathy groups (non-clinical). Absolute EHI scores were equally distributed among low and moderate groups, but were significantly lower for the high psychopathy group. These findings suggest that inconsistent handedness is only associated with the upper quartile of psychopathy scores. Also, males showed significantly higher psychopathy scores than females, and the ratio of male to female inconsistent handers decreased as psychopathy score increased. No gender × handedness interaction indicated that both female and male inconsistent handers have higher psychopathy scores than consistent handers. Although significant, the effects were small and 99.6% of participants were not in the range of a potential clinical diagnosis. The reader, therefore, is strongly cautioned against equating inconsistent handedness with psychopathy.

  7. Wave-induced release of methane : littoral zones as a source of methane in lakes

    Hofmann, Hilmar; Federwisch, Luisa; Peeters, Frank


    This study investigates the role of surface waves and the associated disturbance of littoral sediments for the release and later distribution of dissolved methane in lakes. Surface wave field, wave-induced currents, acoustic backscatter strength, and the concentration and distribution of dissolved methane were measured simultaneously in Lake Constance, Germany. The data indicate that surface waves enhance the release of dissolved methane in the shallow littoral zone via burst-like releases of...

  8. Bayesian nonparametric estimation and consistency of mixed multinomial logit choice models

    De Blasi, Pierpaolo; Lau, John W; 10.3150/09-BEJ233


    This paper develops nonparametric estimation for discrete choice models based on the mixed multinomial logit (MMNL) model. It has been shown that MMNL models encompass all discrete choice models derived under the assumption of random utility maximization, subject to the identification of an unknown distribution $G$. Noting the mixture model description of the MMNL, we employ a Bayesian nonparametric approach, using nonparametric priors on the unknown mixing distribution $G$, to estimate choice probabilities. We provide an important theoretical support for the use of the proposed methodology by investigating consistency of the posterior distribution for a general nonparametric prior on the mixing distribution. Consistency is defined according to an $L_1$-type distance on the space of choice probabilities and is achieved by extending to a regression model framework a recent approach to strong consistency based on the summability of square roots of prior probabilities. Moving to estimation, slightly different te...

  9. Consistency of EEG source localization and connectivity estimates.

    Mahjoory, Keyvan; Nikulin, Vadim V; Botrel, Loïc; Linkenkaer-Hansen, Klaus; Fato, Marco M; Haufe, Stefan


    As the EEG inverse problem does not have a unique solution, the sources reconstructed from EEG and their connectivity properties depend on forward and inverse modeling parameters such as the choice of an anatomical template and electrical model, prior assumptions on the sources, and further implementational details. In order to use source connectivity analysis as a reliable research tool, there is a need for stability across a wider range of standard estimation routines. Using resting state EEG recordings of N=65 participants acquired within two studies, we present the first comprehensive assessment of the consistency of EEG source localization and functional/effective connectivity metrics across two anatomical templates (ICBM152 and Colin27), three electrical models (BEM, FEM and spherical harmonics expansions), three inverse methods (WMNE, eLORETA and LCMV), and three software implementations (Brainstorm, Fieldtrip and our own toolbox). Source localizations were found to be more stable across reconstruction pipelines than subsequent estimations of functional connectivity, while effective connectivity estimates where the least consistent. All results were relatively unaffected by the choice of the electrical head model, while the choice of the inverse method and source imaging package induced a considerable variability. In particular, a relatively strong difference was found between LCMV beamformer solutions on one hand and eLORETA/WMNE distributed inverse solutions on the other hand. We also observed a gradual decrease of consistency when results are compared between studies, within individual participants, and between individual participants. In order to provide reliable findings in the face of the observed variability, additional simulations involving interacting brain sources are required. Meanwhile, we encourage verification of the obtained results using more than one source imaging procedure. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. White Dwarf Mass Distribution

    Kepler, S O; Romero, Alejandra Daniela; Ourique, Gustavo; Pelisoli, Ingrid


    We present the mass distribution for all S/N > 15 pure DA white dwarfs detected in the Sloan Digital Sky Survey up to Data Release 12, fitted with Koester models for ML2/alpha=0.8, and with Teff > 10 000 K, and for DBs with S/N >10, fitted with ML2/alpha=1.25, for Teff > 16 000 K. These mass distributions are for log g > 6.5 stars, i.e., excluding the Extremely Low Mass white dwarfs. We also present the mass distributions corrected by volume with the 1/Vmax approach, for stars brighter than g=19. Both distributions have a maximum at M=0.624 Msun but very distinct shapes. From the estimated z-distances, we deduce a disk scale height of 300 pc. We also present 10 probable halo white dwarfs, from their galactic U, V, W velocities.

  11. Consistently Showing Your Best Side? Intra-individual Consistency in #Selfie Pose Orientation

    Lindell, Annukka K.


    Painted and photographic portraits of others show an asymmetric bias: people favor their left cheek. Both experimental and database studies confirm that the left cheek bias extends to selfies. To date all such selfie studies have been cross-sectional; whether individual selfie-takers tend to consistently favor the same pose orientation, or switch between multiple poses, remains to be determined. The present study thus examined intra-individual consistency in selfie pose orientations. Two hundred selfie-taking participants (100 male and 100 female) were identified by searching #selfie on Instagram. The most recent 10 single-subject selfies for the each of the participants were selected and coded for type of selfie (normal; mirror) and pose orientation (left, midline, right), resulting in a sample of 2000 selfies. Results indicated that selfie-takers do tend to consistently adopt a preferred pose orientation (α = 0.72), with more participants showing an overall left cheek bias (41%) than would be expected by chance (overall right cheek bias = 31.5%; overall midline bias = 19.5%; no overall bias = 8%). Logistic regression modellng, controlling for the repeated measure of participant identity, indicated that sex did not affect pose orientation. However, selfie type proved a significant predictor when comparing left and right cheek poses, with a stronger left cheek bias for mirror than normal selfies. Overall, these novel findings indicate that selfie-takers show intra-individual consistency in pose orientation, and in addition, replicate the previously reported left cheek bias for selfies and other types of portrait, confirming that the left cheek bias also presents within individuals’ selfie corpora.

  12. Consistently Showing Your Best Side? Intra-individual Consistency in #Selfie Pose Orientation.

    Lindell, Annukka K


    Painted and photographic portraits of others show an asymmetric bias: people favor their left cheek. Both experimental and database studies confirm that the left cheek bias extends to selfies. To date all such selfie studies have been cross-sectional; whether individual selfie-takers tend to consistently favor the same pose orientation, or switch between multiple poses, remains to be determined. The present study thus examined intra-individual consistency in selfie pose orientations. Two hundred selfie-taking participants (100 male and 100 female) were identified by searching #selfie on Instagram. The most recent 10 single-subject selfies for the each of the participants were selected and coded for type of selfie (normal; mirror) and pose orientation (left, midline, right), resulting in a sample of 2000 selfies. Results indicated that selfie-takers do tend to consistently adopt a preferred pose orientation (α = 0.72), with more participants showing an overall left cheek bias (41%) than would be expected by chance (overall right cheek bias = 31.5%; overall midline bias = 19.5%; no overall bias = 8%). Logistic regression modellng, controlling for the repeated measure of participant identity, indicated that sex did not affect pose orientation. However, selfie type proved a significant predictor when comparing left and right cheek poses, with a stronger left cheek bias for mirror than normal selfies. Overall, these novel findings indicate that selfie-takers show intra-individual consistency in pose orientation, and in addition, replicate the previously reported left cheek bias for selfies and other types of portrait, confirming that the left cheek bias also presents within individuals' selfie corpora.

  13. Press-coating of immediate release powders onto coated controlled release tablets with adhesives.

    Waterman, Kenneth C; Fergione, Michael B


    A novel adhesive coating was developed that allows even small quantities of immediate-release (IR) powders to be press-coated onto controlled-release (CR), coated dosage forms without damaging the CR coating. The process was exemplified using a pseudoephedrine osmotic tablet (asymmetric membrane technology, AMT) where a powder weighing less than 25% of the core was pressed onto the osmotic tablet providing a final combination tablet with low friability. The dosage form with the adhesive plus the press-coated powder showed comparable sustained drug release rates to the untreated dosage form after an initial 2-h lag. The adhesive layer consisted of an approximately 100- microm coating of Eudragit RL, polyethylene glycol (PEG) and triethyl citrate (TEC) at a ratio of 5:3:1.2. This coating provides a practical balance between handleability before press-coating and good adhesion.

  14. Assessment of the Consistency among Precipitation Products over Arid Regions

    Ghebreyesus, Dawit; Temimi, Marouane


    products were found to be imprecise on their estimation of the precipitation with high uncertainty. The regional analysis was conducted to investigate the consistency among the precipitation products spatially across the Arabian Peninsula. The Relative Mean Absolute Difference was calculated. Results show that RMAD value maintained a persistent spatial distribution throughout the years. Plus, spatially distributed RMAD displayed a pattern that is in agreement with land surface properties. This result is in agreement with previous studies that indicates the uncertainty in the remote sensed estimation is highly dependent on the characteristics of the land surface.

  15. Roles Distribution and Group Identification in Sport Teams with Joint-Consistent Interaction Mode

    A.B. Kolosov


    Full Text Available The article presents comparative analysis of differentiated space choice, presenting subjectively perceived ground of concrete athlete personal activity within Ukrainian National Fencing Team (13 women and 12 men. The received data gives reasons to believe that role repertoire of the team depends on team identification, but at the same time it has impact on activity redistribution inside the group, significant for competition actions regulation and optimal formation determination.

  16. Consistent Measurements of $\\alpha_{s}$ from Precise Oriented Event Shape Distributions

    Abreu, P.; Adye, T.; Adzic, P.; Albrecht, Z.; Alderweireld, T.; Alekseev, G.D.; Alemany, R.; Allmendinger, T.; Allport, P.P.; Almehed, S.; Amaldi, U.; Amapane, N.; Amato, S.; Anassontzis, E.G.; Andersson, P.; Andreazza, A.; Andringa, S.; Antilogus, P.; Apel, W.D.; Arnoud, Y.; Asman, B.; Augustin, J.E.; Augustinus, A.; Baillon, P.; Bambade, P.; Barao, F.; Barbiellini, G.; Barbier, R.; Bardin, D.Yu.; Barker, G.J.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.H.; Begalli, M.; Behrmann, A.; Beilliere, P.; Belokopytov, Yu.; Benekos, N.C.; Benvenuti, A.C.; Berat, C.; Berggren, M.; Bertini, D.; Bertrand, D.; Besancon, M.; Bigi, M.; Bilenky, Mikhail S.; Bizouard, M.A.; Bloch, D.; Blom, H.M.; Bonesini, M.; Bonivento, W.; Boonekamp, M.; Booth, P.S.L.; Borgland, A.W.; Borisov, G.; Bosio, C.; Botner, O.; Boudinov, E.; Bouquet, B.; Bourdarios, C.; Bowcock, T.J.V.; Boyko, I.; Bozovic, I.; Bozzo, M.; Branchini, P.; Brenke, T.; Brenner, R.A.; Bruckman, P.; Brunet, J.M.; Bugge, L.; Buran, T.; Burgsmuller, T.; Buschbeck, B.; Buschmann, P.; Cabrera, S.; Caccia, M.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Carroll, L.; Caso, C.; Castillo Gimenez, M.V.; Cattai, A.; Cavallo, F.R.; Chabaud, V.; Charpentier, P.; Chaussard, L.; Checchia, P.; Chelkov, G.A.; Chierici, R.; Chochula, P.; Chorowicz, V.; Chudoba, J.; Cieslik, K.; Collins, P.; Contri, R.; Cortina, E.; Cosme, G.; Cossutti, F.; Cowell, J.H.; Crawley, H.B.; Crennell, D.; Crepe-Renaudin, Sabine; Crosetti, G.; Cuevas Maestro, J.; Czellar, S.; Davenport, M.; Da Silva, W.; Deghorain, A.; Della Ricca, G.; Delpierre, P.; Demaria, N.; De Angelis, A.; De Boer, W.; De Clercq, C.; De Lotto, B.; De Min, A.; De Paula, L.; Dijkstra, H.; Di Ciaccio, L.; Dolbeau, J.; Doroba, K.; Dracos, M.; Drees, J.; Dris, M.; Duperrin, A.; Durand, J.D.; Eigen, G.; Ekelof, T.; Ekspong, G.; Ellert, M.; Elsing, M.; Engel, J.P.; Erzen, B.; Espirito Santo, M.C.; Fanourakis, G.; Fassouliotis, D.; Fayot, J.; Feindt, M.; Ferrari, P.; Ferrer, A.; Ferrer-Ribas, E.; Ferro, F.; Fichet, S.; Firestone, A.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fontanelli, F.; Franek, B.; Frodesen, A.G.; Fruhwirth, R.; Fulda-Quenzer, F.; Fuster, J.; Galloni, A.; Gamba, D.; Gamblin, S.; Gandelman, M.; Garcia, C.; Gaspar, C.; Gaspar, M.; Gasparini, U.; Gavillet, P.; Gazis, Evangelos; Gele, D.; Ghodbane, N.; Gil Botella, Ines; Glege, F.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Gonzalez Caballero, I.; Gopal, G.; Gorn, L.; Gracco, V.; Grahl, J.; Graziani, E.; Green, C.; Grimm, H.J.; Gris, P.; Grosdidier, G.; Grzelak, K.; Gunther, M.; Guy, J.; Hahn, F.; Hahn, S.; Haider, S.; Hallgren, A.; Hamacher, K.; Hansen, J.; Harris, F.J.; Hedberg, V.; Heising, S.; Hernandez, J.J.; Herquet, P.; Herr, H.; Hessing, T.L.; Heuser, J.M.; Higon, E.; Holmgren, S.O.; Holt, P.J.; Hoorelbeke, S.; Houlden, M.; Hrubec, J.; Huet, K.; Hughes, G.J.; Hultqvist, K.; Jackson, John Neil; Jacobsson, R.; Jalocha, P.; Janik, R.; Jarlskog, C.; Jarlskog, G.; Jarry, P.; Jean-Marie, B.; Johansson, Erik Karl; Jonsson, P.; Joram, C.; Juillot, P.; Kapusta, Frederic; Karafasoulis, K.; Katsanevas, S.; Katsoufis, E.C.; Keranen, R.; Kersevan, B.P.; Khomenko, B.A.; Khovansky, N.N.; Kiiskinen, A.; King, B.; Kinvig, A.; Kjaer, N.J.; Klapp, O.; Klein, Hansjorg; Kluit, P.; Kokkinias, P.; Koratzinos, M.; Kourkoumelis, C.; Kuznetsov, O.; Krammer, M.; Kriznic, E.; Krumshtein, Z.; Kubinec, P.; Kurowska, J.; Kurvinen, K.; Lamsa, J.W.; Lane, D.W.; Langefeld, P.; Laugier, J.P.; Lauhakangas, R.; Leder, G.; Ledroit, Fabienne; Lefebure, V.; Leinonen, L.; Leisos, A.; Leitner, R.; Lemonne, J.; Lenzen, G.; Lepeltier, V.; Lesiak, T.; Lethuillier, M.; Libby, J.; Liko, D.; Lipniacka, A.; Lippi, I.; Lorstad, B.; Loken, J.G.; Lopes, J.H.; Lopez, J.M.; Lopez-Fernandez, R.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Mahon, J.R.; Maio, A.; Malek, A.; Malmgren, T.G.M.; Maltezos, S.; Malychev, V.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Martinez-Vidal, F.; Marti i Garcia, S.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Matthiae, G.; Mazzucato, F.; Mazzucato, M.; McCubbin, M.; McKay, R.; McNulty, R.; McPherson, G.; Meroni, C.; Meyer, W.T.; Migliore, E.; Mirabito, L.; Mitaroff, W.A.; Mjornmark, U.; Moa, T.; Moch, M.; Moller, Rasmus; Monig, Klaus; Monge, M.R.; Moreau, X.; Morettini, P.; Morton, G.; Muller, U.; Munich, K.; Mulders, M.; Mulet-Marquis, C.; Muresan, R.; Murray, W.J.; Muryn, B.; Myatt, G.; Myklebust, T.; Naraghi, F.; Nassiakou, M.; Navarria, F.L.; Navas, Sergio; Nawrocki, K.; Negri, P.; Nemecek, S.; Neufeld, N.; Nicolaidou, R.; Nielsen, B.S.; Niezurawski, P.; Nikolenko, M.; Nomokonov, V.; Normand, A.; Nygren, A.; Olshevsky, A.G.; Onofre, A.; Orava, R.; Orazi, G.; Osterberg, K.; Ouraou, A.; Paganoni, M.; Paiano, S.; Pain, R.; Paiva, R.; Palacios, J.; Palka, H.; Papadopoulou, T.D.; Papageorgiou, K.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Pegoraro, M.; Peralta, L.; Pernicka, M.; Perrotta, A.; Petridou, C.; Petrolini, A.; Phillips, H.T.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Pol, M.E.; Polok, G.; Poropat, P.; Pozdnyakov, V.; Privitera, P.; Pukhaeva, N.; Pullia, A.; Radojicic, D.; Ragazzi, S.; Rahmani, H.; Ratoff, P.N.; Read, Alexander L.; Rebecchi, P.; Redaelli, Nicola Giuseppe; Regler, M.; Reid, D.; Reinhardt, R.; Renton, P.B.; Resvanis, L.K.; Richard, F.; Ridky, J.; Rinaudo, G.; Rodrigo, German; Rohne, O.; Romero, A.; Ronchese, P.; Rosenberg, E.I.; Rosinsky, P.; Roudeau, P.; Rovelli, T.; Royon, C.; Ruhlmann-Kleider, V.; Ruiz, A.; Saarikko, H.; Sacquin, Y.; Sadovsky, A.; Sajot, G.; Salt, J.; Sampsonidis, D.; Sannino, M.; Schneider, H.; Schwemling, P.; Schwering, B.; Schwickerath, U.; Schyns, M.A.E.; Scuri, Fabrizio; Seager, P.; Sedykh, Yu.; Segar, A.M.; Sekulin, R.; Shellard, R.C.; Sheridan, A.; Siebel, M.; Simard, L.; Simonetto, F.; Sisakian, A.N.; Smadja, G.; Smirnova, O.; Smith, G.R.; Sopczak, A.; Sosnowski, R.; Spassoff, T.; Spiriti, E.; Sponholz, P.; Squarcia, S.; Stanescu, C.; Stanic, S.; Stevenson, K.; Stocchi, A.; Strauss, J.; Strub, R.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Tabarelli, T.; Tegenfeldt, F.; Terranova, F.; Thomas, J.; Timmermans, Jan; Tinti, N.; Tkachev, L.G.; Todorova, S.; Tomaradze, A.; Tome, B.; Tonazzo, A.; Tortora, L.; Transtromer, G.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Tsirou, A.; Turluer, M.L.; Tyapkin, I.A.; Tzamarias, S.; Ullaland, O.; Valenti, G.; Vallazza, E.; Vander Velde, C.; Van Apeldoorn, G.W.; Van Dam, Piet; Van Doninck, Walter; Van Eldik, J.; Van Lysebetten, A.; Van Remortel, N.; Van Vulpen, I.; Vassilopoulos, N.; Vegni, G.; Ventura, L.; Venus, W.; Verbeure, F.; Verlato, M.; Vertogradov, L.S.; Verzi, V.; Vilanova, D.; Vitale, L.; Vodopianov, A.S.; Vollmer, C.; Voulgaris, G.; Vrba, V.; Wahlen, H.; Walck, C.; Weiser, C.; Wicke, D.; Wickens, J.H.; Wilkinson, G.R.; Winter, M.; Witek, M.; Wolf, G.; Yi, J.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zevgolatakos, E.; Zimine, N.I.; Zucchelli, G.C.; Zumerle, G.


    An updated analysis using about 1.5 million events recorded at $\\sqrt{s} =M_Z$ with the DELPHI detector in 1994 is presented. Eighteen infrared and collinear safe event shape observables are measured as a function of the polar angle of the thrust axis. The data are compared to theoretical calculations in${\\cal O} (\\alpha_s^2)$ including the event orientation. A combined fit of $\\alpha_s$ and of the renormalization scale $x_{\\mu}$ in $\\cal O(\\alpha_s^2$)yields an excellent description of the high statistics data. The weighted average from 18 observables including quark mass effects and correlations is $\\alpha_s(M_Z^2) = 0.1174 \\pm 0.0026$. The final result, derived from the jet cone energy fraction, the observable with the smallest theoretical and experimental uncertainty, is $\\alpha_s(M_Z^2) = =0:1180 0:0006(exp:) 0:0013(hadr:) 0:0008(scale) 0:0007(mass). Further studies include an s determination using theoretical predictions in the next-to-leading log approximation (NLLA), matched NLLA and O(\\alpha^{2}_{s})...

  17. Roles Distribution and Group Identification in Sport Teams with Joint-Consistent Interaction Mode

    A.B. Kolosov; S.M. Voutenko


    The article presents comparative analysis of differentiated space choice, presenting subjectively perceived ground of concrete athlete personal activity within Ukrainian National Fencing Team (13 women and 12 men). The received data gives reasons to believe that role repertoire of the team depends on team identification, but at the same time it has impact on activity redistribution inside the group, significant for competition actions regulation and optimal formation determination.

  18. Striatal dopamine release codes uncertainty in pathological gambling

    Linnet, Jakob; Mouridsen, Kim; Peterson, Ericka


    Two mechanisms of midbrain and striatal dopaminergic projections may be involved in pathological gambling: hypersensitivity to reward and sustained activation toward uncertainty. The midbrain-striatal dopamine system distinctly codes reward and uncertainty, where dopaminergic activation is a linear......]raclopride to measure dopamine release, and we used performance on the Iowa Gambling Task (IGT) to determine overall reward and uncertainty. We hypothesized that we would find a linear function between dopamine release and IGT performance, if dopamine release coded reward in pathological gambling. If, on the other hand......, dopamine release coded uncertainty, we would find an inversely U-shaped function. The data supported an inverse U-shaped relation between striatal dopamine release and IGT performance if the pathological gambling group, but not in the healthy control group. These results are consistent with the hypothesis...

  19. Striatal dopamine release codes uncertainty in pathological gambling

    Linnet, Jakob; Mouridsen, Kim; Peterson, Ericka


    Two mechanisms of midbrain and striatal dopaminergic projections may be involved in pathological gambling: hypersensitivity to reward and sustained activation toward uncertainty. The midbrain—striatal dopamine system distinctly codes reward and uncertainty, where dopaminergic activation is a linear...... dopamine release, and we used performance on the Iowa Gambling Task (IGT) to determine overall reward and uncertainty. We hypothesized that we would find a linear function between dopamine release and IGT performance, if dopamine release coded reward in pathological gambling. If, on the other hand......, dopamine release coded uncertainty, we would find an inversely U-shaped function. The data supported an inverse U-shaped relation between striatal dopamine release and IGT performance if the pathological gambling group, but not in the healthy control group. These results are consistent with the hypothesis...

  20. Striatal dopamine release codes uncertainty in pathological gambling

    Linnet, Jakob; Mouridsen, Kim; Peterson, Ericka


    Two mechanisms of midbrain and striatal dopaminergic projections may be involved in pathological gambling: hypersensitivity to reward and sustained activation toward uncertainty. The midbrain—striatal dopamine system distinctly codes reward and uncertainty, where dopaminergic activation is a linear...... dopamine release, and we used performance on the Iowa Gambling Task (IGT) to determine overall reward and uncertainty. We hypothesized that we would find a linear function between dopamine release and IGT performance, if dopamine release coded reward in pathological gambling. If, on the other hand......, dopamine release coded uncertainty, we would find an inversely U-shaped function. The data supported an inverse U-shaped relation between striatal dopamine release and IGT performance if the pathological gambling group, but not in the healthy control group. These results are consistent with the hypothesis...

  1. Generation and release of radioactive gases in LLW disposal facilities

    Yim, M.S. [Harvard School Public Health, Boston, MA (United States); Simonson, S.A. [Massachusetts Institute of Technology, Cambridge, MA (United States)


    The atmospheric release of radioactive gases from a generic engineered LLW disposal facility and its radiological impacts were examined. To quantify the generation of radioactive gases, detailed characterization of source inventory for carbon-14, tritium, iodine-129, krypton-85, and radon-222, was performed in terms of their activity concentrations; their distribution within different waste classes, waste forms and containers; and their subsequent availability for release in volatile or gaseous form. The generation of gases was investigated for the processes of microbial activity, radiolysis, and corrosion of waste containers and metallic components in wastes. The release of radionuclides within these gases to the atmosphere was analyzed under the influence of atmospheric pressure changes.

  2. GnRH在青年摩杂一代水牛下丘脑-垂体-卵巢轴的免疫组化定位%Distribution of Gonadotropin (GnRH) Releasing Hormone in Hypothalamus-pituitary-ovary Axis of Youth Murrah Hybrid Water Buffalo

    凌泽继; 李瑞明; 谢莹雪; 周辰瑜; 黎金秀; 秦津; 潘堂峰; 宋小白; 杨柄壮; 许典新; 韩涛; 潘琼


    [Objective] The research aimed to study the distribution of gonadotropin (GnRH) releasing hormone in hypothalamus-pituitary-ovary axis of youth murrah hybrid water buffalo.[Method] The immunohistochemistry SuperPicTureTM two step method was used to detect the distribution of GnRH in hypothalamus-pituitary-ovary axis of five femal murrah hybrid water buffalos.The association of GnRH 's distribution in hypothalamus, pituitary and ovary, and understand how the GnRH secrete releasing in hypothalamus, pituitary and ovary.[Result] The GnRH was first discovered in singulorum link of hypothalamus-pituitary-ovary axis of murrah hybrid water bufflo.The GnRH immunoreactive neurons were first discovered in every main nucleus of murrah hybrid water bufflo hypothalamus, especially distributed in supraoptic nucleus, preoptic nucleus, paraventricular nucleus most.The GnRH immunoactive productions were first discovered only in murrah hybrid water bufflo adenohypophysis for pituitary.The GnRH immunoactive productions were first discovered in the germinal epithelium cells, granulosa cells and lutein cells of murrah hybrid water bufflo.[Conclusion] The test results could provide morphological basis for the study of the GnRH's synthesis and mechanism of action, and could play reference and directions part in breeding murrah hybrid water bufflo.%[目的]研究促性腺激素释放激素(GnRH)在青年摩杂一代水牛下丘脑-垂体-卵巢轴的免疫组化定位.[方法]采用免疫组织化学SuperPicTureTM二步法检测5头青年摩杂一代水牛下丘脑、垂体和卵巢中GnRH的分布情况,研究GnRH在下丘脑、垂体及卵巢的分布上的联系,进而了解GnRH在下丘脑、垂体及卵巢三者之间分泌释放的途径.[结果]GnRH存在于青年摩杂一代水牛下丘脑-垂体-卵巢轴的各个环节.青年摩杂一代水牛下丘脑中各主要核团都有GnRH免疫阳性神经元的分布,尤其以视上核、视前核、室旁核分布较多.对于垂体,Gn

  3. Hot Melt Extrusion for Sustained Protein Release: Matrix Erosion and In Vitro Release of PLGA-Based Implants.

    Cossé, Anne; König, Corinna; Lamprecht, Alf; Wagner, Karl G


    The design of biodegradable implants for sustained release of proteins is a complex challenge optimizing protein polymer interaction in combination with a mini-scale process which is predictive for production. The process of hot melt extrusion (HME) was therefore conducted on 5- and 9-mm mini-scale twin screw extruders. Poly(lactic-co-glycolic acid) (PLGA) implants were characterized for their erosion properties and the in vitro release of the embedded protein (bovine serum albumin, BSA). The release of acidic monomers as well as other parameters (pH value, mass loss) during 16 weeks indicated a delayed onset of matrix erosion in week 3. BSA-loaded implants released 17.0% glycolic and 5.9% lactic acid after a 2-week lag time. Following a low burst release (3.7% BSA), sustained protein release started in week 4. Storage under stress conditions (30°C, 75% rH) revealed a shift of erosion onset of 1 week (BSA-loaded implants: 26.9% glycolic and 9.3% lactic acid). Coherent with the changed erosion profiles, an influence on the protein release was observed. Confocal laser scanning and Raman microscopy showed a homogenous protein distribution throughout the matrix after extrusion and during release studies. Raman spectra indicated a conformational change of the protein structure which could be one reason for incomplete protein release. The study underlined the suitability of the HME process to obtain a solid dispersion of protein inside a polymeric matrix providing sustained protein release. However, the incomplete protein release and the impact by storage conditions require thorough characterization and understanding of erosion and release mechanisms.

  4. Implications of the Khrgian-Mazin Distribution Function for Water Clouds and Distribution Consistencies With Aerosols and Rain


    URSS , IX. Ballistic Research Laboratory (1982) Millimeter-wave Propagation at 35, 95, 140 and 217 GHz Frequencies Through Snowfall, SNVOW-ONE-A Data...Soc. Amer. 50:876-882. Ge, Run-Sheng (1983) Radar meteorology of 20 years in China . Meteor. Science and Technique. No. 2, 7-14. Geiler, E.I. and

  5. Optogenetic control of ATP release

    Lewis, Matthew A.; Joshi, Bipin; Gu, Ling; Feranchak, Andrew; Mohanty, Samarendra K.


    Controlled release of ATP can be used for understanding extracellular purinergic signaling. While coarse mechanical forces and hypotonic stimulation have been utilized in the past to initiate ATP release from cells, these methods are neither spatially accurate nor temporally precise. Further, these methods cannot be utilized in a highly effective cell-specific manner. To mitigate the uncertainties regarding cellular-specificity and spatio-temporal release of ATP, we herein demonstrate use of optogenetics for ATP release. ATP release in response to optogenetic stimulation was monitored by Luciferin-Luciferase assay (North American firefly, photinus pyralis) using luminometer as well as mesoscopic bioluminescence imaging. Our result demonstrates repetitive release of ATP subsequent to optogenetic stimulation. It is thus feasible that purinergic signaling can be directly detected via imaging if the stimulus can be confined to single cell or in a spatially-defined group of cells. This study opens up new avenue to interrogate the mechanisms of purinergic signaling.

  6. Cobalt release from inexpensive jewellery

    Thyssen, Jacob Pontoppidan; Jellesen, Morten Stendahl; Menné, Torkil


    Objectives: The aim was to study 354 consumer items using the cobalt spot test. Cobalt release was assessed to obtain a risk estimate of cobalt allergy and dermatitis in consumers who would wear the jewellery. Methods: The cobalt spot test was used to assess cobalt release from all items....... Microstructural characterization was made using scanning electron microscope (SEM) and energy-dispersive spectroscopy (EDS). Results: Cobalt release was found in 4 (1.1%) of 354 items. All these had a dark appearance. SEM/EDS was performed on the four dark appearing items which showed tin-cobalt plating on these....... Conclusions: This study showed that only a minority of inexpensive jewellery purchased in Denmark released cobalt when analysed with the cobalt spot test. As fashion trends fluctuate and we found cobalt release from dark appearing jewellery, cobalt release from consumer items should be monitored in the future...

  7. Product consistency testing of West Valley Compositional Variation Glasses

    Olson, K.M.; Marschman, S.C.; Piepel, G.F.; Whiting, G.K.


    Nuclear waste glass produced by the West Valley Demonstration Project (WVDP) must meet the requirements of the Waste Acceptance Preliminary Specification (WAPS) as developed by the US Department of Energy (DOE). To assist WVDP in complying with WAPS, the Materials Characterization Center (MCC) at Pacific Northwest Laboratory (PNL) used the Product Consistency Test (PCT) to evaluate 44 West Valley glasses that had previously been tested in FY 1987 and FY 1988. This report summarizes the results of the PCTs. The glasses tested, which were fabricated as sets of Compositional Variation Glasses for studies performed by the West Valley Support Task (WVST) at PNL during FY 1987 and FY 1988, were doped with Th and U and were variations of West Valley reference glasses. In addition, Approved Reference Material-1 (ARM-1) was used as a test standard (ARM-1 is supplied by the MCC). The PCT was originated at Westinghouse Savannah River Company (WSRC) by C. M. Jantzen and N. R. Bibler (Jantzen and Bibler 1989). The test is a seven-day modified MCC-3 test that uses crushed glass in the size range -100 +200 mesh with deionized water in a Teflon container. There is no agitation during the PCT, and no attempt to include CO{sub 2} from the test environment. Based on B and Li release, the glasses performed about the same as in previous modified MCC-3 testing performed in FY 1987 and FY 1988 (Reimus et al. 1988). The modified MCC-3 tests performed by Reimus et al. were similar to the PCT containers and the exclusion of CO{sub 2} from the tests.

  8. Release Early, Release Often: Predicting Change in Versioned Knowledge Organization Systems on the Web

    Meroño-Peñuela, Albert; Guéret, Christophe; Schlobach, Stefan


    The Semantic Web is built on top of Knowledge Organization Systems (KOS) (vocabularies, ontologies, concept schemes) that provide a structured, interoperable and distributed access to Linked Data on the Web. The maintenance of these KOS over time has produced a number of KOS version chains: subsequent unique version identifiers to unique states of a KOS. However, the release of new KOS versions pose challenges to both KOS publishers and users. For publishers, updating a KOS is a knowledge int...


    S.O. Bader


    The purpose of this design analysis is to specify and document the total and respirable fractions for radioactive materials that are released from an accident event at the Monitored Geologic Repository (MGR) involving commercial spent nuclear fuel (CSNF) in a dry environment. The total and respirable release fractions will be used to support the preclosure licensing basis for the MGR. The total release fraction is defined as the fraction of total CSNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. The radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses. This subset of the total release fraction is referred to as the respirable release fraction. Potential accidents may involve waste forms that are characterized as either bare (unconfined) fuel assemblies or confined fuel assemblies. The confined CSNF assemblies at the MGR are contained in shipping casks, canisters, or disposal containers (waste packages). In contrast to the bare fuel assemblies, the container that confines the fuel assemblies has the potential of providing an additional barrier for diminishing the total release fraction should the fuel rod cladding breach during an accident. However, this analysis will not take credit for this additional bamer and will establish only the total release fractions for bare unconfined CSNF assemblies, which may however be

  10. Externally controlled triggered-release of drug from PLGA micro and nanoparticles.

    Xin Hua

    Full Text Available Biofilm infections are extremely hard to eradicate and controlled, triggered and controlled drug release properties may prolong drug release time. In this study, the ability to externally control drug release from micro and nanoparticles was investigated. We prepared micro/nanoparticles containing ciprofloxacin (CIP and magnetic nanoparticles encapsulated in poly (lactic-co-glycolic acid PLGA. Both micro/nanoparticles were observed to have narrow size distributions. We investigated and compared their passive and externally triggered drug release properties based on their different encapsulation structures for the nano and micro systems. In passive release studies, CIP demonstrated a fast rate of release in first 2 days which then slowed and sustained release for approximately 4 weeks. Significantly, magnetic nanoparticles containing systems all showed ability to have triggered drug release when exposed to an external oscillating magnetic field (OMF. An experiment where the OMF was turned on and off also confirmed the ability to control the drug release in a pulsatile manner. The magnetically triggered release resulted in a 2-fold drug release increase compared with normal passive release. To confirm drug integrity following release, the antibacterial activity of released drug was evaluated in Pseudomonas aeruginosa biofilms in vitro. CIP maintained its antimicrobial activity after encapsulation and triggered release.

  11. Self-consistent Kinetic Description of the Low-Pressure Solenoidal Inductively Coupled Argon Discharge

    毛明; 王友年


    Using an one-dimensional slab model, we have studied the electron energy distribution, the anomalous skin effect, and power absorption in the solenoidal-inductively-coupled argon discharge under low pressures (≤1.33 Pa). The electron energy distribution function and rf electromagnetic field in the plasma are determined self-consistently by the linearized Bolztmann equation incorporating with the Maxwell equations. The numerical results show that, at low pressures, the electron energy distribution function exhibits a non-Maxwellian distribution with a long high-energy tail. The anomalous skin effect is greatly enhanced under low pressures and the negative power absorption is also obtained.

  12. Using Complex Networks to Quantify Consistency in the Use of Words

    Amancio, Diego R; Costa, Luciano da F; 10.1088/1742-5468/2012/01/P01004


    In this paper we quantify the consistency of word usage in written texts represented by complex networks, where words were taken as nodes, by measuring the degree of preservation of the node neighborhood.} Words were considered highly consistent if the authors used them with the same neighborhood. When ranked according to the consistency of use, the words obeyed a log-normal distribution, in contrast to the Zipf's law that applies to the frequency of use. Consistency correlated positively with the familiarity and frequency of use, and negatively with ambiguity and age of acquisition. An inspection of some highly consistent words confirmed that they are used in very limited semantic contexts. A comparison of consistency indices for 8 authors indicated that these indices may be employed for author recognition. Indeed, as expected authors of novels could be distinguished from those who wrote scientific texts. Our analysis demonstrated the suitability of the consistency indices, which can now be applied in other ...

  13. Depth preference in released juvenile turbot Psetta maxima

    Albertsen, Christoffer Moesgaard; Støttrup, Josianne; Nielsen, Anders


    Hatchery-reared juvenile turbot Psetta maxima were tagged with Passive Integrated Transponder (PIT) tags and released at three different depths in a sandy bay in Denmark. About 2–7% of the released fish were registered daily to monitor their distribution using a tag antenna mounted on a modified...... beam trawl, thus avoiding actually sampling the fish. The change in distribution of the three groups was adequately represented by a twodimensional movement model. Movement along the shorewas described by a Brownianmotion with group specific drift.Movement perpendicular to the shore linewas described...

  14. Efficient reconstruction of contaminant release history

    Alezander, Francis [Los Alamos National Laboratory; Anghel, Marian [Los Alamos National Laboratory; Gulbahce, Natali [NON LANL; Tartakovsky, Daniel [NON LANL


    We present a generalized hybrid Monte Carlo (GHMC) method for fast, statistically optimal reconstruction of release histories of reactive contaminants. The approach is applicable to large-scale, strongly nonlinear systems with parametric uncertainties and data corrupted by measurement errors. The use of discrete adjoint equations facilitates numerical implementation of GHMC, without putting any restrictions on the degree of nonlinearity of advection-dispersion-reaction equations that are used to described contaminant transport in the subsurface. To demonstrate the salient features of the proposed algorithm, we identify the spatial extent of a distributed source of contamination from concentration measurements of a reactive solute.

  15. Testing and distribution of the RPS2 proposal submission system

    Douglas, Robert E.


    In 1995, the Space Telescope Science Institute (STScI) introduced RPS2 (Remote Proposal Submission 2). RPS2 is used by Hubble Space TElescope (HST) proposers to prepare their detailed observation descriptions. It is a client/server system implemented using Tcl/Tk. The client can transparently access servers on the user's machine, at STScI, or on any other machine on the Internet. The servers combine syntax checking, feasibility analysis and orbit packing, and constraint and schedulability analysis of user- specified proposals as they will be performed aboard HST. Prior to the release of RPS2, observers used a system which provided only syntax checking. RPS2 now provides the observers with some of the more complicated pieces of software that had been used by STScI staff to prepare observations since 1990. The RPS2 system consists of four independent subsystem, controlled by the client/server mechanism. A problem with a system of this size and complexity is that the software components, which continue to grow and change with HST itself, must continually be tested and distributed to those who need it. In the past, it had been acceptable to release the RPS2 software only once per observing cycle, but it became apparent before the 1997 HST Servicing Mission that multiple releases of RPS2 were going to be required to support the new instruments. This paper discusses how RPS2 and its component systems are maintained, updated, tested, and distributed.

  16. The Intrinsic Eddington Ratio Distribution of Active Galactic Nuclei in Star-forming Galaxies from the Sloan Digital Sky Survey

    Jones, M L; Black, C S; Hainline, K N; DiPompeo, M A; Goulding, A D


    An important question in extragalactic astronomy concerns the distribution of black hole accretion rates of active galactic nuclei (AGN). Based on observations at X-ray wavelengths, the observed Eddington ratio distribution appears as a power law, while optical studies have often yielded a lognormal distribution. There is increasing evidence that these observed discrepancies may be due to contamination by star formation and other selection effects. Using a sample of galaxies from the Sloan Digital Sky Survey Data Release 7, we test if an intrinsic Eddington ratio distribution that takes the form of a Schechter function is consistent with previous work that suggests that young galaxies in optical surveys have an observed lognormal Eddington ratio distribution. We simulate the optical emission line properties of a population of galaxies and AGN using a broad instantaneous luminosity distribution described by a Schechter function near the Eddington limit. This simulated AGN population is then compared to observe...

  17. Bayesian detection of causal rare variants under posterior consistency.

    Liang, Faming


    Identification of causal rare variants that are associated with complex traits poses a central challenge on genome-wide association studies. However, most current research focuses only on testing the global association whether the rare variants in a given genomic region are collectively associated with the trait. Although some recent work, e.g., the Bayesian risk index method, have tried to address this problem, it is unclear whether the causal rare variants can be consistently identified by them in the small-n-large-P situation. We develop a new Bayesian method, the so-called Bayesian Rare Variant Detector (BRVD), to tackle this problem. The new method simultaneously addresses two issues: (i) (Global association test) Are there any of the variants associated with the disease, and (ii) (Causal variant detection) Which variants, if any, are driving the association. The BRVD ensures the causal rare variants to be consistently identified in the small-n-large-P situation by imposing some appropriate prior distributions on the model and model specific parameters. The numerical results indicate that the BRVD is more powerful for testing the global association than the existing methods, such as the combined multivariate and collapsing test, weighted sum statistic test, RARECOVER, sequence kernel association test, and Bayesian risk index, and also more powerful for identification of causal rare variants than the Bayesian risk index method. The BRVD has also been successfully applied to the Early-Onset Myocardial Infarction (EOMI) Exome Sequence Data. It identified a few causal rare variants that have been verified in the literature.

  18. Workload Control with Continuous Release

    Phan, B. S. Nguyen; Land, M. J.; Gaalman, G. J. C.


    Workload Control (WLC) is a production planning and control concept which is suitable for the needs of make-to-order job shops. Release decisions based on the workload norms form the core of the concept. This paper develops continuous time WLC release variants and investigates their due date

  19. Press Oil Final Release Survey

    Whicker, Jeffrey Jay [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ruedig, Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    There are forty-eight 55 gallon barrels filled with hydraulic oil that are candidates for release and recycle. This oil needs to be characterized prior to release. Principles of sampling as provided in MARSAME/MARSSIM approaches were used as guidance for sampling.

  20. Sucrose release from polysaccharide gels.

    Nishinari, Katsuyoshi; Fang, Yapeng


    Sucrose release from polysaccharide gels has been studied extensively because it is expected to be useful in understanding flavour release from solid foods and to find a new processing method which produces more palatable and healthier foods. We provide an overview of the release of sucrose and other sugars from gels of agar and related polysaccharides. The addition of sucrose to agar solutions leads to the increase in transparency of the resulting gels and the decrease in syneresis, which is attributed to the decrease in mesh size in gels. The syneresis occurring in the quiescent condition and fluid release induced by compression is discussed. The relationship between the sugar release and the structural, rheological and thermal properties of gels is also discussed. Finally, the future research direction is proposed.

  1. Dry release of suspended nanostructures

    Forsén, Esko Sebastian; Davis, Zachary James; Dong, M.;


    A dry release method for fabrication of suspended nanostructures is presented. The technique has been combined with an anti-stiction treatment for fabrication of nanocantilever based nanoelectromechanical systems (NEMS). The process combines a dry release method, using a supporting layer of photo......A dry release method for fabrication of suspended nanostructures is presented. The technique has been combined with an anti-stiction treatment for fabrication of nanocantilever based nanoelectromechanical systems (NEMS). The process combines a dry release method, using a supporting layer......, the technique enables long time storage and transportation of produced devices without the risk of stiction. By combining the dry release method with a plasma deposited anti-stiction coating both fabrication induced stiction, which is mainly caused by capillary forces originating from the dehydration...

  2. Age consistency between exoplanet hosts and field stars

    Bonfanti, A.; Ortolani, S.; Nascimbeni, V.


    Context. Transiting planets around stars are discovered mostly through photometric surveys. Unlike radial velocity surveys, photometric surveys do not tend to target slow rotators, inactive or metal-rich stars. Nevertheless, we suspect that observational biases could also impact transiting-planet hosts. Aims: This paper aims to evaluate how selection effects reflect on the evolutionary stage of both a limited sample of transiting-planet host stars (TPH) and a wider sample of planet-hosting stars detected through radial velocity analysis. Then, thanks to uniform derivation of stellar ages, a homogeneous comparison between exoplanet hosts and field star age distributions is developed. Methods: Stellar parameters have been computed through our custom-developed isochrone placement algorithm, according to Padova evolutionary models. The notable aspects of our algorithm include the treatment of element diffusion, activity checks in terms of log{R'HK} and vsini, and the evaluation of the stellar evolutionary speed in the Hertzsprung-Russel diagram in order to better constrain age. Working with TPH, the observational stellar mean density ρ⋆ allows us to compute stellar luminosity even if the distance is not available, by combining ρ⋆ with the spectroscopic log g. Results: The median value of the TPH ages is 5 Gyr. Even if this sample is not very large, however the result is very similar to what we found for the sample of spectroscopic hosts, whose modal and median values are [3, 3.5) Gyr and 4.8 Gyr, respectively. Thus, these stellar samples suffer almost the same selection effects. An analysis of MS stars of the solar neighbourhood belonging to the same spectral types bring to an age distribution similar to the previous ones and centered around solar age value. Therefore, the age of our Sun is consistent with the age distribution of solar neighbourhood stars with spectral types from late F to early K, regardless of whether they harbour planets or not. We considered

  3. Protein release from electrospun nonwovens: improving the release characteristics through rational combination of polyester blend matrices with polidocanol.

    Puhl, Sebastian; Ilko, David; Li, Linhao; Holzgrabe, Ulrike; Meinel, Lorenz; Germershaus, Oliver


    Nonwoven scaffolds consisting of poly-ε-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) and polidocanol (PD), and loaded with lysozyme crystals were prepared by electrospinning. The composition of the matrix was varied and the effect of PD content in binary mixtures, and of PD and PLGA content in ternary mixtures regarding processability, fiber morphology, water sorption, swelling and drug release was investigated. Binary PCL/PD blend nonwovens showed a PD-dependent increase in swelling of up to 30% and of lysozyme burst release of up to 45% associated with changes of the fiber morphology. Furthermore, addition of free PD to the release medium resulted in a significant increase of lysozyme burst release from pure PCL nonwovens from approximately 2-35%. Using ternary PCL/PD/PLGA blends, matrix degradation could be significantly improved over PCL/PD blends, resulting in a biphasic release of lysozyme with constant release over 9 weeks, followed by constant release with a reduced rate over additional 4 weeks. Based on these results, protein release from PCL scaffolds is improved by blending with PD due to improved lysozyme desorption from the polymer surface and PD-dependent matrix swelling. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Nitrogen release during coal combustion

    Baxter, L.L.; Mitchell, R.E.; Fletcher, T.H.; Hurt, R.H.


    Experiments in entrained flow reactors at combustion temperatures are performed to resolve the rank dependence of nitrogen release on an elemental basis for a suite of 15 U.S. coals ranging from lignite to low-volatile bituminous. Data were obtained as a function of particle conversion, with overall mass loss up to 99% on a dry, ash-free basis. Nitrogen release rates are presented relative to both carbon loss and overall mass loss. During devolatilization, fractional nitrogen release from low-rank coals is much slower than fractional mass release and noticeably slower than fractional carbon release. As coal rank increases, fractional nitrogen release rate relative to that of carbon and mass increases, with fractional nitrogen release rates exceeding fractional mass and fractional carbon release rates during devolatilization for high-rank (low-volatile bituminous) coals. At the onset of combustion, nitrogen release rates increase significantly. For all coals investigated, cumulative fractional nitrogen loss rates relative to those of mass and carbon passes through a maximum during the earliest stages of oxidation. The mechanism for generating this maximum is postulated to involve nascent thermal rupture of nitrogen-containing compounds and possible preferential oxidation of nitrogen sites. During later stages of oxidation, the cumulative fractional loss of nitrogen approaches that of carbon for all coals. Changes in the relative release rates of nitrogen compared to those of both overall mass and carbon during all stages of combustion are attributed to a combination of the chemical structure of coals, temperature histories during combustion, and char chemistry.

  5. The First Data Release of the KODIAQ Survey

    O'Meara, J M; Howk, J C; Prochaska, J X; Fox, A J; Swain, M A; Gelino, C R; Berriman, G B; Tran, H


    We present and make publicly available the first data release (DR1) of the Keck Observatory Database of Ionized Absorption toward Quasars (KODIAQ) survey. The KODIAQ survey is aimed at studying galactic and circumgalactic gas in absorption at high-redshift, with a focus on highly-ionized gas traced by OVI, using the HIRES spectrograph on the Keck-I telescope. KODIAQ DR1 consists of a fully-reduced sample of 170 quasars at 0.29 < z_em < 5.29 observed with HIRES at high resolution (36,000 <= R <= 103,000) between 2004 and 2012. DR1 contains 247 spectra available in continuum normalized form, representing a sum total exposure time of ~1.6 megaseconds. These co-added spectra arise from a total of 567 individual exposures of quasars taken from the Keck Observatory Archive (KOA) in raw form and uniformly processed using a HIRES data reduction package made available through the XIDL distribution. DR1 is publicly available to the community, housed as a higher level science product at the KOA. We will prov...

  6. Data acquisition backbone core DABC release v1.0

    Adamczewski-Musch, Joern; Essel, Hans G.; Kurz, Nikolaus; Linev, S. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany)


    The new experiments at FAIR require new concepts of data acquisition systems for the distribution of self-triggered, time stamped data streams over high performance networks for event building. The Data Acquisition Backbone Core (DABC) is a general purpose software framework developed for the implementation of such data acquisition systems. A DABC application consists of functional components like data input, combiner, scheduler, event builder, filter, analysis and storage which can be configured at runtime. Application specific code including the support of all kinds of data channels (front-end systems) is implemented by C++ program plug-ins. DABC is also well suited as environment for various detector and readout components test beds. A set of DABC plug-ins has been developed for the FAIR experiment CBM (Compressed Baryonic Matter) at GSI. This DABC application is used as DAQ system for test beamtimes. Front-end boards equipped with n-XYTER ASICs and ADCs are connected to read-out controller boards (ROC). From there the data is sent over Ethernet (UDP), or over optics and PCIe interface cards into Linux PCs. DABC does the controlling, event building, archiving and data serving. The first release of DABC was published in 2009 and is available under GPL license.

  7. Contaminant release history reconstruction through empirical Bayes and Akaike's Bayesian Information Criterion

    Zanini, A.; Woodbury, A. D.


    Contaminant release history identification has received considerable attention in the literature over the past several decades. In our review of this subject suggests that improvements are needed in terms of a reliable procedure, one that is easy to implement, with only few hyperparameters to estimate, and is able to evaluate confidence intervals. The purpose of this work is to propose an empirical Bayesian approach combined with the Akaike's Bayesian Information Criterion (ABIC) to estimate the contaminant release history starting from concentration observations in time or space. From the Bayesian point of view, the ABIC considers prior information on the unknown function, such as the prior distribution (assumed Gaussian) and the covariance function. The unknown statistical quantities, such as the noise variance and the covariance function parameters, are computed through the process; moreover the method also quantifies the estimation error through confidence intervals. We successfully test the method out on three test cases: the classic Skaggs and Kabala (1994) source, a "midnight dump" example that consists of three delta-like sources and lastly a laboratory dataset, consisting of two measurement points spatially but with synoptic observations. This experiment reproduces the response of a 2-D unconfined aquifer. The performance of the inverse method was tested with two different covariance functions (Gaussian and exponential) and also with large measurement error. Results show an excellent recovery of all sources used in the examples. Lastly, the obtained results were discussed and compared to the geostatistical approach of Kitanidis (1995).

  8. MAP estimators and their consistency in Bayesian nonparametric inverse problems

    Dashti, M.; Law, K. J. H.; Stuart, A. M.; Voss, J.


    We consider the inverse problem of estimating an unknown function u from noisy measurements y of a known, possibly nonlinear, map {G} applied to u. We adopt a Bayesian approach to the problem and work in a setting where the prior measure is specified as a Gaussian random field μ0. We work under a natural set of conditions on the likelihood which implies the existence of a well-posed posterior measure, μy. Under these conditions, we show that the maximum a posteriori (MAP) estimator is well defined as the minimizer of an Onsager-Machlup functional defined on the Cameron-Martin space of the prior; thus, we link a problem in probability with a problem in the calculus of variations. We then consider the case where the observational noise vanishes and establish a form of Bayesian posterior consistency for the MAP estimator. We also prove a similar result for the case where the observation of {G}(u) can be repeated as many times as desired with independent identically distributed noise. The theory is illustrated with examples from an inverse problem for the Navier-Stokes equation, motivated by problems arising in weather forecasting, and from the theory of conditioned diffusions, motivated by problems arising in molecular dynamics.

  9. Consistent Steering System using SCTP for Bluetooth Scatternet Sensor Network

    Dhaya, R.; Sadasivam, V.; Kanthavel, R.


    Wireless communication is the best way to convey information from source to destination with flexibility and mobility and Bluetooth is the wireless technology suitable for short distance. On the other hand a wireless sensor network (WSN) consists of spatially distributed autonomous sensors to cooperatively monitor physical or environmental conditions, such as temperature, sound, vibration, pressure, motion or pollutants. Using Bluetooth piconet wireless technique in sensor nodes creates limitation in network depth and placement. The introduction of Scatternet solves the network restrictions with lack of reliability in data transmission. When the depth of the network increases, it results in more difficulties in routing. No authors so far focused on the reliability factors of Scatternet sensor network's routing. This paper illustrates the proposed system architecture and routing mechanism to increase the reliability. The another objective is to use reliable transport protocol that uses the multi-homing concept and supports multiple streams to prevent head-of-line blocking. The results show that the Scatternet sensor network has lower packet loss even in the congestive environment than the existing system suitable for all surveillance applications.

  10. MAP estimators and their consistency in Bayesian nonparametric inverse problems

    Dashti, M.


    We consider the inverse problem of estimating an unknown function u from noisy measurements y of a known, possibly nonlinear, map applied to u. We adopt a Bayesian approach to the problem and work in a setting where the prior measure is specified as a Gaussian random field μ0. We work under a natural set of conditions on the likelihood which implies the existence of a well-posed posterior measure, μy. Under these conditions, we show that the maximum a posteriori (MAP) estimator is well defined as the minimizer of an Onsager-Machlup functional defined on the Cameron-Martin space of the prior; thus, we link a problem in probability with a problem in the calculus of variations. We then consider the case where the observational noise vanishes and establish a form of Bayesian posterior consistency for the MAP estimator. We also prove a similar result for the case where the observation of can be repeated as many times as desired with independent identically distributed noise. The theory is illustrated with examples from an inverse problem for the Navier-Stokes equation, motivated by problems arising in weather forecasting, and from the theory of conditioned diffusions, motivated by problems arising in molecular dynamics. © 2013 IOP Publishing Ltd.

  11. On the consistency of seismically imaged lower mantle slabs.

    Shephard, G E; Matthews, K J; Hosseini, K; Domeier, M


    The geoscience community is increasingly utilizing seismic tomography to interpret mantle heterogeneity and its links to past tectonic and geodynamic processes. To assess the robustness and distribution of positive seismic anomalies, inferred as subducted slabs, we create a set of vote maps for the lower mantle with 14 global P-wave or S-wave tomography models. Based on a depth-dependent threshold metric, an average of 20% of any given tomography model depth is identified as a potential slab. However, upon combining the 14 models, the most consistent positive wavespeed features are identified by an increasing vote count. An overall peak in the most robust anomalies is found between 1000-1400 km depth, followed by a decline to a minimum around 2000 km. While this trend could reflect reduced tomographic resolution in the middle mantle, we show that it may alternatively relate to real changes in the time-dependent subduction flux and/or a mid-lower mantle viscosity increase. An apparent secondary peak in agreement below 2500 km depth may reflect the degree-two lower mantle slow seismic structures. Vote maps illustrate the potential shortcomings of using a limited number or type of tomography models and slab threshold criteria.

  12. Mechanisms involved in ketone body release by rat liver cells: influence of pH and bicarbonate

    Fafournoux, P.; Demigne, C.; Remesy, C.


    The aim of the present work is to study the intra- and extracellular concentration gradient of ketone bodies across the hepatic cell membrane, ketone bodies released by liver cells, and the effects of changes in acid-base status on these processes. Ketone bodies appeared to be released by liver cells against a concentration gradient both in vivo and in vitro. In vitro, a decrease in external pH and bicarbonate gradient measured with ( UC)- and (TH)-labelled compounds, and efflux rates. Analysis of the distribution ratio of ketone bodies as a function of pH across the cell membrane indicates that additional factors must be invoked to account for the observed distribution ratios. These data along with measurement of ketone body efflux are consistent with the existence of a system promoting the efflux of ketone bodies from liver cells, which is trans-stimulated by external bicarbonate. In vivo, ketogenesis was also inhibited by acidosis, and slightly enhanced by bicarbonate infusion, although this was not solely due to effects on transfer across the cell membrane. The study indicates that the hepatic release of ketone bodies might be auto-limited by ketoacidosis.

  13. The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles.

    Islam, Aminul; Shen, Xiaoyan; Hiroi, Toyoko; Moss, Joel; Vaughan, Martha; Levine, Stewart J


    The type I, 55-kDa tumor necrosis factor receptor (TNFR1) is released from cells to the extracellular space where it can bind and modulate TNF bioactivity. Extracellular TNFR1 release occurs by two distinct pathways: the inducible proteolytic cleavage of TNFR1 ectodomains and the constitutive release of full-length TNFR1 in exosome-like vesicles. Regulation of both TNFR1 release pathways appears to involve the trafficking of cytoplasmic TNFR1 vesicles. Vesicular trafficking is controlled by ADP-ribosylation factors (ARFs), which are active in the GTP-bound state and inactive when bound to GDP. ARF activation is enhanced by guanine nucleotide-exchange factors that catalyze replacement of GDP by GTP. We investigated whether the brefeldin A (BFA)-inhibited guanine nucleotide-exchange proteins, BIG1 and/or BIG2, are required for TNFR1 release from human umbilical vein endothelial cells. Effects of specific RNA interference (RNAi) showed that BIG2, but not BIG1, regulated the release of TNFR1 exosome-like vesicles, whereas neither BIG2 nor BIG1 was required for the IL-1beta-induced proteolytic cleavage of TNFR1 ectodomains. BIG2 co-localized with TNFR1 in diffusely distributed cytoplasmic vesicles, and the association between BIG2 and TNFR1 was disrupted by BFA. Consistent with the preferential activation of class I ARFs by BIG2, ARF1 and ARF3 participated in the extracellular release of TNFR1 exosome-like vesicles in a nonredundant and additive fashion. We conclude that the association between BIG2 and TNFR1 selectively regulates the extracellular release of TNFR1 exosome-like vesicles from human vascular endothelial cells via an ARF1- and ARF3-dependent mechanism.

  14. The Illustris Simulation: Public Data Release

    Nelson, Dylan; Genel, Shy; Vogelsberger, Mark; Springel, Volker; Torrey, Paul; Rodriguez-Gomez, Vicente; Sijacki, Debora; Snyder, Gregory F; Griffen, Brendan; Marinacci, Federico; Blecha, Laura; Sales, Laura; Xu, Dandan; Hernquist, Lars


    We present the full public release of all data from the Illustris simulation project. Illustris is a suite of large volume, cosmological hydrodynamical simulations run with the moving-mesh code Arepo and including a comprehensive set of physical models critical for following the formation and evolution of galaxies across cosmic time. Each simulates a volume of (106.5 Mpc)^3 and self-consistently evolves five different types of resolution elements from a starting redshift of z=127 to the present day, z=0. These components are: dark matter particles, gas cells, passive gas tracers, stars and stellar wind particles, and supermassive black holes. This data release includes the snapshots at all 136 available redshifts, halo and subhalo catalogs at each snapshot, and two distinct merger trees. Six primary realizations of the Illustris volume are released, including the flagship Illustris-1 run. These include three resolution levels with the fiducial "full" baryonic physics model, and a dark matter only analog for e...

  15. Film coatings for oral pulsatile release.

    Maroni, Alessandra; Zema, Lucia; Loreti, Giulia; Palugan, Luca; Gazzaniga, Andrea


    Pulsatile delivery is generally intended as a release of the active ingredient that is delayed for a programmable period of time to meet particular chronotherapeutic needs and, in the case of oral administration, also target distal intestinal regions, such as the colon. Most oral pulsatile delivery platforms consist in coated formulations wherein the applied polymer serves as the release-controlling agent. When exposed to aqueous media, the coating initially performs as a protective barrier and, subsequently, undergoes a timely failure based on diverse mechanisms depending on its physico-chemical and formulation characteristics. Indeed, it may be ruptured because of the gradual expansion of the core, swell and/or erode due to the glassy-rubbery polymer transition or become permeable thus allowing the drug molecules to diffuse outwards. Otherwise, when the coating is a semipermeable membrane provided with one or more orifices, the drug is released through the latter as a result of an osmotic water influx. The vast majority of pulsatile delivery systems described so far have been prepared by spray-coating, which offers important versatility and feasibility advantages over other techniques such as press- and dip-coating. In the present article, the design, manufacturing and performance of spray-coated pulsatile delivery platforms is thus reviewed.

  16. Chlorhexidine-releasing methacrylate dental composite materials.

    Leung, Danny; Spratt, David A; Pratten, Jonathan; Gulabivala, Kishor; Mordan, Nicola J; Young, Anne M


    Light curable antibacterial, dental composite restoration materials, consisting of 80 wt% of a strontium fluoroaluminosilicate glass dispersed in methacrylate monomers have been produced. The monomers contained 40-100 wt% of a 10 wt% chlorhexidine diacetate (CHXA) in hydroxyethylmethacrylate (HEMA) solution and 60-0 wt% of a 50/50 mix of urethane dimethacrylate (UDMA) and triethyleneglycol dimethacrylate (TEGDMA). On raising HEMA content, light cure polymerisation rates decreased. Conversely, water sorption induced swelling and rates of diffusion controlled CHXA release from the set materials increased. Experimental composites with 50 and 90 wt% of the CHXA in HEMA solution in the monomer were shown, within a constant depth film fermentor (CDFF), to have slower rates of biofilm growth on their surfaces between 1 and 7 days than the commercial dental composite Z250 or fluoride-releasing dental cements, Fuji II LC and Fuji IX. When an excavated bovine dentine cylinder re-filled with Z250 was placed for 10 weeks in the CDFF, both bacteria and polymers from the artificial saliva penetrated between the material and dentine. With the 50 wt% experimental HEMA/CHXA formulation, this bacterial microleakage was substantially reduced. Polymer leakage, however, still occurred. Both polymer and bacterial microleakage were prevented with a 90 wt% HEMA/CHXA restoration in the bovine dentine due to swelling compensation for polymerisation shrinkage in combination with antibacterial release.

  17. Distribution Structures

    Friedrich, H.; Tavasszy, L.A.; Davydenko, I.


    Distribution structures are important elements of the freight transportation system. Goods are routed via warehouses on their way from production to consumption. This chapter discusses drivers behind these structures, logistics decisions connected to distribution structures on the micro level, and

  18. Distributed Knight

    Hansen, Klaus Marius; Damm, Christian Heide


    An extension of Knight (2005) that support distributed synchronous collaboration implemented using type-based publish/subscribe......An extension of Knight (2005) that support distributed synchronous collaboration implemented using type-based publish/subscribe...

  19. GRS constraints on the character of possible ancient oceans on Mars: consistencies with Earth analogues

    James M. Dohm; Baker, Victor R.; Boynton, William V.; González Fairén, Alberto; Ferris, Justin C.; Finch, Michael; Furfaro, Roberto; Hare, Trent M.; Janes, Daniel M.; Kargel, Jeffrey S.; Karunatillake, Suniti; Keller, John; Kerry, Kris; Kim, Kyeong; Komatsu, Goro


    The Gamma Ray Spectrometer (GRS) has revealed elemental distributions of potassium (K), thorium (Th), and iron (Fe) on Mars that require fractionation of K (and possibly the others) consistent with aqueous weathering, transport, sorting, and deposition in the northern plains basins, as well as first-order geomorphological boundaries identified as putative shorelines. The elemental abundances occur in patterns consistent with deposition of weathered materials (salts and clastic minerals) and w...

  20. Commercial SNF Accident Release Fractions

    J. Schulz


    The purpose of this analysis is to specify and document the total and respirable fractions for radioactive materials that could be potentially released from an accident at the repository involving commercial spent nuclear fuel (SNF) in a dry environment. The total and respirable release fractions are used to support the preclosure licensing basis for the repository. The total release fraction is defined as the fraction of total commercial SNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. Radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses; this subset of the total release fraction is referred to as the respirable release fraction. Accidents may involve waste forms characterized as: (1) bare unconfined intact fuel assemblies, (2) confined intact fuel assemblies, or (3) canistered failed commercial SNF. Confined intact commercial SNF assemblies at the repository are contained in shipping casks, canisters, or waste packages. Four categories of failed commercial SNF are identified: (1) mechanically and cladding-penetration damaged commercial SNF, (2) consolidated/reconstituted assemblies, (3) fuel rods, pieces, and debris, and (4) nonfuel components. It is assumed that failed commercial SNF is placed into waste packages with a mesh screen at each end (CRWMS M&O 1999). In contrast to bare unconfined fuel assemblies, the

  1. Real-time luminescence imaging of cellular ATP release.

    Furuya, Kishio; Sokabe, Masahiro; Grygorczyk, Ryszard


    Extracellular ATP and other purines are ubiquitous mediators of local intercellular signaling within the body. While the last two decades have witnessed enormous progress in uncovering and characterizing purinergic receptors and extracellular enzymes controlling purinergic signals, our understanding of the initiating step in this cascade, i.e., ATP release, is still obscure. Imaging of extracellular ATP by luciferin-luciferase bioluminescence offers the advantage of studying ATP release and distribution dynamics in real time. However, low-light signal generated by bioluminescence reactions remains the major obstacle to imaging such rapid processes, imposing substantial constraints on its spatial and temporal resolution. We have developed an improved microscopy system for real-time ATP imaging, which detects ATP-dependent luciferin-luciferase luminescence at ∼10 frames/s, sufficient to follow rapid ATP release with sensitivity of ∼10 nM and dynamic range up to 100 μM. In addition, simultaneous differential interference contrast cell images are acquired with infra-red optics. Our imaging method: (1) identifies ATP-releasing cells or sites, (2) determines absolute ATP concentration and its spreading manner at release sites, and (3) permits analysis of ATP release kinetics from single cells. We provide instrumental details of our approach and give several examples of ATP-release imaging at cellular and tissue levels, to illustrate its potential utility.

  2. Analysis of multiple tank car releases in train accidents.

    Liu, Xiang; Liu, Chang; Hong, Yili


    There are annually over two million carloads of hazardous materials transported by rail in the United States. The American railroads use large blocks of tank cars to transport petroleum crude oil and other flammable liquids from production to consumption sites. Being different from roadway transport of hazardous materials, a train accident can potentially result in the derailment and release of multiple tank cars, which may result in significant consequences. The prior literature predominantly assumes that the occurrence of multiple tank car releases in a train accident is a series of independent Bernoulli processes, and thus uses the binomial distribution to estimate the total number of tank car releases given the number of tank cars derailing or damaged. This paper shows that the traditional binomial model can incorrectly estimate multiple tank car release probability by magnitudes in certain circumstances, thereby significantly affecting railroad safety and risk analysis. To bridge this knowledge gap, this paper proposes a novel, alternative Correlated Binomial (CB) model that accounts for the possible correlations of multiple tank car releases in the same train. We test three distinct correlation structures in the CB model, and find that they all outperform the conventional binomial model based on empirical tank car accident data. The analysis shows that considering tank car release correlations would result in a significantly improved fit of the empirical data than otherwise. Consequently, it is prudent to consider alternative modeling techniques when analyzing the probability of multiple tank car releases in railroad accidents. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Release and perception of aroma compounds during consumption

    Weel, K.G.C.


    Key words: MS-Nose, in vivo aroma release, aroma perception, mouth model, artificial throat, liquid protocol, sweeteners, reversible protein-aroma interactions, emulsions, oil content, droplet size distribution, gel hardness, texture, cross-modal interactions.This thesis evaluated and validated the

  4. Release and perception of aroma compounds during consumption

    Weel, K.G.C.


    Key words: MS-Nose, in vivo aroma release, aroma perception, mouth model, artificial throat, liquid protocol, sweeteners, reversible protein-aroma interactions, emulsions, oil content, droplet size distribution, gel hardness, texture, cross-modal interactions.This thesis evaluated and validated the

  5. Preparation of Cotton-Wool-Like Poly(lactic acid-Based Composites Consisting of Core-Shell-Type Fibers

    Jian Wang


    Full Text Available In previous works, we reported the fabrication of cotton-wool-like composites consisting of siloxane-doped vaterite and poly(l-lactic acid (SiVPCs. Various irregularly shaped bone voids can be filled with the composite, which effectively supplies calcium and silicate ions, enhancing the bone formation by stimulating the cells. The composites, however, were brittle and showed an initial burst release of ions. In the present work, to improve the mechanical flexibility and ion release, the composite fiber was coated with a soft, thin layer consisting of poly(d,l-lactic-co-glycolic acid (PLGA. A coaxial electrospinning technique was used to prepare a cotton-wool-like material comprising “core-shell”-type fibers with a diameter of ~12 µm. The fibers, which consisted of SiVPC coated with a ~2-µm-thick PLGA layer, were mechanically flexible; even under a uniaxial compressive load of 1.5 kPa, the cotton-wool-like material did not exhibit fracture of the fibers and, after removing the load, showed a ~60% recovery. In Tris buffer solution, the initial burst release of calcium and silicate ions from the “core-shell”-type fibers was effectively controlled, and the ions were slowly released after one day. Thus, the mechanical flexibility and ion-release behavior of the composites were drastically improved by the thin PLGA coating.

  6. Universal spectrum for DNA base CG frequency distribution in Takifugu rubripes (Puffer fish) genome

    Selvam, A M


    The frequency distribution of DNA bases A, C, G, T exhibit fractal fluctuations, namely a zigzag pattern of an increase followed by a decrease of all orders of magnitude along the length of the DNA molecule. Selfsimilar fractal fluctuations are ubiquitous to space-time fluctuations of dynamical systems in nature. The power spectra of fractal fluctuations exhibit inverse power law form signifying long-range space-time correlations such that there is two-way communication between local (small-scale) and global (large-scale) perturbations. In this paper it is shown that DNA base CG frequency distribution in Takifugu rubripes (Puffer fish) Genome Release 4 exhibit universal inverse power law form of the statistical normal distribution consistent with a general systems theory model prediction of quantumlike chaos governing fractal space-time distributions. The model predictions are (i) quasicrystalline Penrose tiling pattern for the nested coiled structure thereby achieving maximum packing efficiency for the DNA m...

  7. Competitive release and outbreaks of non-target pests associated with transgenic Bt cotton.

    Zeilinger, Adam R; Olson, Dawn M; Andow, David A


    The adoption of transgenic Bt cotton has, in some cases, led to environmental and economic benefits through reduced insecticide use. However, the distribution of these benefits and associated risks among cotton growers and cotton-growing regions has been uneven due in part to outbreaks of non-target or secondary pests, thereby requiring the continued use of synthetic insecticides. In the southeastern USA, Bt cotton adoption has resulted in increased abundance of and damage from stink bug pests, Euschistus servus and Nezara viridula (Heteroptera: Pentatomidae). While the impact of increased stink bug abundance has been well-documented, the causes have remained unclear. We hypothesize that release from competition with Bt-susceptible target pests may drive stink bug outbreaks in Bt cotton. We first examined the evidence for competitive release of stink bugs through meta-analysis of previous studies. We then experimentally tested if herbivory by Bt-susceptible Helicoverpa zea increases stink bug leaving rates and deters oviposition on non-Bt cotton. Consistent with previous studies, we found differences in leaving rates only for E servus, but we found that both species strongly avoided ovipositing on H. zea-damaged plants. Considering all available evidence, competitive release of stink bug populations in Bt cotton likely contributes to outbreaks, though the relative importance of competitive release remains an open question. Ecological risk assessments of Bt crops and other transgenic insecticidal crops would benefit from greater understanding of the ecological mechanisms underlying non-target pest outbreaks and greater attention to indirect ecological effects more broadly.

  8. Birth control - slow release methods

    ... page: // Birth control - slow release methods To use the sharing features on this page, please enable JavaScript. Certain birth control methods contain man-made forms of hormones. These ...

  9. Turbulent lock release gravity current


    The time evolution of a turbulent lock release gravity current, formed by a finite volume ofhomogeneous fluid released instantaneously into another fluid of slightly lower density, was studied byexperimental measurements of the density structure via elaborate digital image processing and by a nu-merical simulation of the flow and mixing using a two-equation turbulence model. The essential fact thatthe gravity current passes through an initial slumping phase in which the current head advances steadilyand a second self-similar phase in which the front velocity decreases like the negative third power of thetime after release is satisfactorily presented by the laboratory observation. An overall entrainment ratioproportional to the distance from the release point is found by the numerical simulation. The renormal-ization group (RNG) k- ε model for Reynolds-stress closure is validated to characterize the gravitycurrent with transitional and localized turbulence.

  10. Distributed computing

    Van Renesse, R


    This series will start with an introduction to distributed computing systems. Distributed computing paradigms will be presented followed by a discussion on how several important contemporary distributed operating systems use these paradigms. Topics will include processing paradigms, storage paradigms, scalability and robustness. Throughout the course everything will be illustrated by modern distributed systems notably the Amoeba distributed operating system of the Free University in Amsterdam and the Plan 9 operating system of AT&T Bell Laboratories. Plan 9 is partly designed and implemented by Ken Thompson, the main person behind the successful UNIX operating system.

  11. PCDD/PCDF release inventories

    Fiedler, H. [UNEP Chemicals, Chatelaine (Switzerland)


    The Stockholm Convention on Persistent Organic Pollutants (POPs) entered into force on 17 May 2004 with 50 Parties. In May 2004, 59 countries had ratified or acceded the Convention. The objective of the Convention is ''to protect human health and the environment from persistent organic pollutants''. For intentionally produced POPs, e.g., pesticides and industrial chemicals such as hexachlorobenzene and polychlorinated biphenyls, this will be achieved by stop of production and use. For unintentionally generated POPs, such as polychlorinated dibenzo-pdioxins (PCDD) and polychlorinated dibenzofurans (PCDF), measures have to be taken to ''reduce the total releases derived from anthropogenic sources''; the final goal is ultimate elimination, where feasible. Under the Convention, Parties have to establish and maintain release inventories to prove the continuous release reduction. Since many countries do not have the technical and financial capacity to measure all releases from all potential PCDD/PCDF sources, UNEP Chemicals has developed the ''Standardized Toolkit for the Identification of Quantification of Dioxin and Furan Releases'' (''Toolkit'' for short), a methodology to estimate annual releases from a number of sources. With this methodology, annual releases can be estimated by multiplying process-specific default emission factors provided in the Toolkit with national activity data. At the seventh session of the Intergovernmental Negotiating Committee, the Toolkit was recommended to be used by countries when reporting national release data to the Conference of the Parties. The Toolkit is especially used by developing countries and countries with economies in transition where no measured data are available. Results from Uruguay, Thailand, Jordan, Philippines, and Brunei Darussalam have been published.

  12. Highly interactive distributed visualization

    Scarpa, M.; Belleman, R.G.; Sloot, P.M.A.; de Laat, C.T.A.M.


    We report on our iGrid2005 demonstration, called the "Dead Cat Demo"; an example of a highly interactive augmented reality application consisting of software services distributed over a wide-area, high-speed network. We describe our design decisions, analyse the implications of the design on applica

  13. Polarized parton distributions

    de Florian, D.; Epele, L.N.; Fanchiotti, H.; Garcia Canal, C.A.; Sassot, R. (Laboratorio de Fisica Teorica, Departamento de Fisica, Universidad Nacional de La Plata, C.C. 67-1900 La Plata (Argentina))


    We analyze spin-dependent parton distributions consistent with the most recent measurements of the spin-dependent deep inelastic scattering structure functions and obtained in the framework of the spin dilution model. Predictions for the doubly polarized proton-proton Drell-Yan asymmetry, for the high [ital p][sub [ital T

  14. Research on consistency measurement and weight estimation approach of hybrid uncertain comparison matrix


    The consistency measurement and weight estimation approach of the hybrid uncertain comparison matrix in the analytic hierarchy process (AHP) are studied. First, the decision-making satisfaction membership function is defined based on the decision making's allowable error. Then, the weight model based on the maximal satisfactory consistency idea is suggested, and the consistency index is put forward. Moreover, the weight distributing value model is developed to solve the decision making misleading problem since the multioptimization solutions in the former model. Finally, the weights are ranked based on the possibility degree approach to obtain the ultimate order.

  15. Bioactive peptides released during of digestion of processed milk

    Most of the proteins contained in milk consist of alpha-s1-, alpha-s2-, beta- and kappa-casein, and some of the peptides contained in these caseins may impart health benefits. To determine if processing affected release of peptides, samples of raw (R), homogenized (H), homogenized and pasteurized (...

  16. Composition for the controlled release of active compounds

    Hovens, I.A.P.; Jongboom, R.O.J.; Stuut, P.I.


    The invention provides a composition for the controlled release of one or more biologically active substances encapsulated in a degradable biopolymer matrix, consisting of a thermoplastic and/or partly crystalline inulin. A plasticiser such as glycerol, and an emulsifier may be present. The active s

  17. Reaction-Multi Diffusion Model for Nutrient Release and Autocatalytic Degradation of PLA-Coated Controlled-Release Fertilizer

    Sayed Ameenuddin Irfan


    Full Text Available A mathematical model for the reaction-diffusion equation is developed to describe the nutrient release profiles and degradation of poly(lactic acid (PLA-coated controlled-release fertilizer. A multi-diffusion model that consists of coupled partial differential equations is used to study the diffusion and chemical reaction (autocatalytic degradation simultaneously. The model is solved using an analytical-numerical method. Firstly, the model equation is transformed using the Laplace transformation as the Laplace transform cannot be inverted analytically. Numerical inversion of the Laplace transform is used by employing the Zakian method. The solution is useful in predicting the nutrient release profiles at various diffusivity, concentration of extraction medium, and reaction rates. It also helps in explaining the transformation of autocatalytic concentration in the coating material for various reaction rates, times of reaction, and reaction-multi diffusion. The solution is also applicable to the other biodegradable polymer-coated controlled-release fertilizers.

  18. Effects of disordered microstructure and heat release on propagation of combustion front

    Naine Tarun Bharath


    Full Text Available Numerical experiments for diagnosis of combustion of actual heterogeneous systems is performed on a one dimensional chain. The internal microstructure of actual heterogeneous systems is apriori unknown, various distributions like uniform, beta and normal have been considered for distributing neighboring reaction cells. Two cases, for the nature of distribution of heat release of reaction cells are taken into account, one with identical heat release and the other with disordered heat release. Role of different random distributions in describing heterogeneous combustion process are established in present paper. Particularly the normal distribution of arranging neighboring reaction cells has been found to be powerful methodology in explaining the combustion process of an actual heterogeneous system at higher ignition temperatures for both cases of distributing heat release. Validation of developed model with the experimental data of combustion of the CMDB propellants, gasless Ti+xSi system and different thermite mixtures is performed. Our results show that the experimental burning rates at higher ignition temperatures (ε>0.32 of the heterogeneous system are better reproduced theoretically with present model. We have also shown that different combustion limit for different thermite systems are the consequences of disordered heat release. Experimental data for thermite systems that have lower inflammability limits are analyzed in the view of disordered heat releases of cells. The model developed in the view of disordered heat releases reproduces the experimental burn rates and experimental combustion limit.

  19. Earthquake depth-energy release: thermomechanical implications for dynamic plate theory

    Patton, Regan L


    Analysis of the global centroid-moment tensor catalog reveals significant regional variations of seismic energy release to 290 km depth. These variations reflect radial and lateral contrasts in thermomechanical competence, consistent with a shear-dominated non-adiabatic boundary layer some 700-km thick, capped by denser oceanic lithosphere as much as 100 km thick, or lighter continental tectosphere 170 to 260 km thick. Thus, isobaric shearing at fractally-distributed depths likely facilitates toroidal plate rotations while minimizing global energy dissipation. Shear localization in the shallow crust occurs as dislocations at finite angles with respect to the shortening direction, with a 30 degree angle being the most likely. Consequently, relatively low-angle reverse faults, steep normal faults, and triple junctions with orthogonal or hexagonal symmetry are likely to form in regions of crustal shortening, extension, and transverse motion, respectively. Thermomechanical theory also predicts adiabatic condition...

  20. A self-consistent dynamo model for fully convective stars

    Yadav, Rakesh Kumar; Christensen, Ulrich; Morin, Julien; Gastine, Thomas; Reiners, Ansgar; Poppenhaeger, Katja; Wolk, Scott J.


    The tachocline region inside the Sun, where the rigidly rotating radiative core meets the differentially rotating convection zone, is thought to be crucial for generating the Sun's magnetic field. Low-mass fully convective stars do not possess a tachocline and were originally expected to generate only weak small-scale magnetic fields. Observations, however, have painted a different picture of magnetism in rapidly-rotating fully convective stars: (1) Zeeman broadening measurements revealed average surface field of several kiloGauss (kG), which is similar to the typical field strength found in sunspots. (2) Zeeman-Doppler-Imaging (ZDI) technique discovered large-scale magnetic fields with a morphology often similar to the Earth's dipole-dominated field. (3) Comparison of Zeeman broadening and ZDI results showed that more than 80% of the magnetic flux resides at small scales. So far, theoretical and computer simulation efforts have not been able to reproduce these features simultaneously. Here we present a self-consistent global model of magnetic field generation in low-mass fully convective stars. A distributed dynamo working in the model spontaneously produces a dipole-dominated surface magnetic field of the observed strength. The interaction of this field with the turbulent convection in outer layers shreds it, producing small-scale fields that carry most of the magnetic flux. The ZDI technique applied to synthetic spectropolarimetric data based on our model recovers most of the large-scale field. Our model simultaneously reproduces the morphology and magnitude of the large-scale field as well as the magnitude of the small-scale field observed on low-mass fully convective stars.

  1. Characterization of consistent triggers of migraine with aura

    Hauge, Anne Werner; Kirchmann, Malene; Olesen, Jes


    The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA).......The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA)....

  2. Characterization of consistent triggers of migraine with aura

    Hauge, Anne Werner; Kirchmann, Malene; Olesen, Jes


    The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA).......The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA)....

  3. The utility of theory of planned behavior in predicting consistent ...


    outcomes of the behavior and the evaluations of these outcomes (behavioral beliefs) ... belief towards consistent condom use and motivation for compliance with .... consistency of the items used before constructing a scale. Results. All of the ...

  4. Generalized contexts and consistent histories in quantum mechanics

    Losada, Marcelo; Laura, Roberto


    We analyze a restriction of the theory of consistent histories by imposing that a valid description of a physical system must include quantum histories which satisfy the consistency conditions for all states. We prove that these conditions are equivalent to imposing the compatibility conditions of our formalism of generalized contexts. Moreover, we show that the theory of consistent histories with the consistency conditions for all states and the formalism of generalized context are equally useful representing expressions which involve properties at different times.

  5. Study on consistent query answering in inconsistent databases

    XIE Dong; YANG Luming


    Consistent query answering is an approach to retrieving consistent answers over databases that might be inconsistent with respect to some given integrity constraints The approach is based on a concept of repair.This paper surveys several recent researches on obtaining consistent information from inconsistent databases,such as the underlying semantic model,a number of approaches to computing consistent query answers and the computational complexity of this problem.Furthermore,the work outlines potential research directions in this area.

  6. Locally self-consistent Green’s function approach to the electronic structure problem

    Abrikosov, I.A.; Simak, S.I.; Johansson, B.;


    The locally self-consistent Green's function (LSGF) method is an order-N method for calculation of the electronic structure of systems with an arbitrary distribution of atoms of different kinds on an underlying crystal lattice. For each atom Dyson's equation is used to solve the electronic multiple...


    Liu Jixue; Chen Xiru


    Consistency of LS estimate of simple linear EV model is studied. It is shown that under some common assumptions of the model, both weak and strong consistency of the estimate are equivalent but it is not so for quadratic-mean consistency.

  8. Checking Consistency of Pedigree Information is NP-complete

    Aceto, Luca; Hansen, Jens A.; Ingolfsdottir, Anna

    Consistency checking is a fundamental computational problem in genetics. Given a pedigree and information on the genotypes of some of the individuals in it, the aim of consistency checking is to determine whether these data are consistent with the classic Mendelian laws of inheritance. This probl...

  9. Non-Numeric Intrajudge Consistency Feedback in an Angoff Procedure

    Harrison, George M.


    The credibility of standard-setting cut scores depends in part on two sources of consistency evidence: intrajudge and interjudge consistency. Although intrajudge consistency feedback has often been provided to Angoff judges in practice, more evidence is needed to determine whether it achieves its intended effect. In this randomized experiment with…

  10. FMCG companies specific distribution channels

    Ioana Barin


    Full Text Available Distribution includes all activities undertaken by the producer, alone or in cooperation, since the end of the final finished products or services until they are in possession of consumers. The distribution consists of the following major components: distribution channels or marketing channels, which together form a distribution network; logistics o rphysical distribution. In order to effective achieve, distribution of goods requires an amount of activities and operational processes related to transit of goods from producer to consumer, the best conditions, using existing distribution channels and logistics system. One of the essential functions of a distribution is performing acts of sale, through which, with the actual movement of goods, their change of ownership takes place, that the successive transfer of ownership from producer to consumer. This is an itinerary in the economic cycle of goods, called the distribution channel.

  11. A biokinetic model for nickel released from cardiovascular devices.

    Saylor, David M; Adidharma, Lingga; Fisher, Jeffrey W; Brown, Ronald P


    Many alloys used in cardiovascular device applications contain high levels of nickel, which if released in sufficient quantities, can lead to adverse health effects. While nickel release from these devices is typically characterized through the use of in-vitro immersion tests, it is unclear if the rate at which nickel is released from a device during in-vitro testing is representative of the release rate following implantation in the body. To address this uncertainty, we have developed a novel biokinetic model that combines a traditional toxicokinetic compartment model with a physics-based model to estimate nickel release from an implanted device. This model links the rate of in-vitro nickel release from a cardiovascular device to serum nickel concentrations, an easily measured endpoint, to estimate the rate and extent of in-vivo nickel release from an implanted device. The model was initially parameterized using data in the literature on in-vitro nickel release from a nickel-containing alloy (nitinol) and baseline serum nickel levels in humans. The results of this first step were then used to validate specific components of the model. The remaining unknown quantities were fit using serum values reported in patients following implantation with nitinol atrial occluder devices. The model is not only consistent with levels of nickel in serum and urine of patients following treatment with the atrial occluders, but also the optimized parameters in the model were all physiologically plausible. The congruity of the model with available data suggests that it can provide a framework to interpret nickel biomonitoring data and use data from in-vitro nickel immersion tests to estimate in-vivo nickel release from implanted cardiovascular devices.

  12. Earthquake recurrence on the south Hayward fault is most consistent with a time dependent, renewal process

    Parsons, T.


    Elastic rebound and stress renewal are important components of earthquake forecasting because if large earthquakes can be shown to be periodic, then rupture probability is time dependent. While renewal models are used in formal forecasts, it has not been possible to exclude the alternate view that repeated large earthquakes can happen in rapid succession without requiring time for stress regeneration. Here a consistency test between time dependent and time independent recurrence distributions is made using a Monte Carlo method to replicate the paleoseismic series on the south Hayward fault. Time dependent distributions with recurrence interval of 210 years and coefficient of variation of 0.6 reproduce the event series on the south Hayward 5 times more often than any exponential distribution: a highly significant difference as determined using a two-tailed Z-test for relative proportions. Therefore large Hayward fault earthquakes are quasi-periodic and are most consistent with a stress renewal process.

  13. Assessing the consistency between short-term global temperature trends in observations and climate model projections

    Michaels, Patrick J; Christy, John R; Herman, Chad S; Liljegren, Lucia M; Annan, James D


    Assessing the consistency between short-term global temperature trends in observations and climate model projections is a challenging problem. While climate models capture many processes governing short-term climate fluctuations, they are not expected to simulate the specific timing of these somewhat random phenomena - the occurrence of which may impact the realized trend. Therefore, to assess model performance, we develop distributions of projected temperature trends from a collection of climate models running the IPCC A1B emissions scenario. We evaluate where observed trends of length 5 to 15 years fall within the distribution of model trends of the same length. We find that current trends lie near the lower limits of the model distributions, with cumulative probability-of-occurrence values typically between 5 percent and 20 percent, and probabilities below 5 percent not uncommon. Our results indicate cause for concern regarding the consistency between climate model projections and observed climate behavior...

  14. Statistical distributions

    Forbes, Catherine; Hastings, Nicholas; Peacock, Brian J.


    A new edition of the trusted guide on commonly used statistical distributions Fully updated to reflect the latest developments on the topic, Statistical Distributions, Fourth Edition continues to serve as an authoritative guide on the application of statistical methods to research across various disciplines. The book provides a concise presentation of popular statistical distributions along with the necessary knowledge for their successful use in data modeling and analysis. Following a basic introduction, forty popular distributions are outlined in individual chapters that are complete with re

  15. On consistency of the weighted arithmetical mean complex judgement matrix


    The weighted arithmetical mean complex judgement matrix(WAMCJM)is the most common method for aggregating group opinions,but it has a shortcoming,namely the WAMCJM of the perfectly consistent judgement matrices given by experts canot guarantee its perfect consistency.An upper bound of the WAMCJM's consistency is presented.Simultaneously,a compatibility index of judging the aggregating extent of group opinions is also introduced.The WAMCJM is of acceptable consistency and is proved provided the compatibilities of all judgement matrices given by experts are smaller than the threshold value of acceptable consistency.These conclusions are important to group decision making.

  16. On multidimensional consistent systems of asymmetric quad-equations

    Boll, Raphael


    Multidimensional Consistency becomes more and more important in the theory of discrete integrable systems. Recently, we gave a classification of all 3D consistent 6-tuples of equations with the tetrahedron property, where several novel asymmetric systems have been found. In the present paper we discuss higher-dimensional consistency for 3D consistent systems coming up with this classification. In addition, we will give a classification of certain 4D consistent systems of quad-equations. The results of this paper allow for a proof of the Bianchi permutability among other applications.

  17. Markers of Decompression Stress of Mass Stranded/Live Caught and Released vs. Single Stranded Marine Mammals


    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Markers of Decompression Stress of Mass Stranded /Live...Caught and Released vs. Single Stranded Marine Mammals Michael Moore Biology Department Woods Hole Oceanographic Institution Woods Hole, MA 02543...analyze blood samples from captive, wild-caught, and stranded marine mammals in order to compare concentrations of Microparticles (MPs). If confirmed

  18. Numerical investigation of degas performance on impeller of medium-consistency pump

    Hong Li


    Full Text Available Medium-consistency technology is known as the process with high efficiency and low pollution. The gas distribution was simulated in the medium-consistency pump with different degas hole positions. Rheological behaviors of pulp suspension were obtained by experimental test. A modified Herschel–Bulkley model and the Eulerian gas–liquid two-phase flow model were utilized to approximately represent the behaviors of the medium-consistency pulp suspension. The results show that when the relative position is 0.53, the gas volume ratio is less than 0.1% at the pump outlet and 9.8% at the vacuum inlet, and the pump head is at the maximum. Because of the different numbers of the impeller blades and turbulence blades and the asymmetric volute structure, the gas is distributed unevenly in the impeller. In addition, the pump performance was tested in experiment and the results are used to validate computational fluid dynamics outcomes.

  19. Distributed Visualization Project

    Craig, Douglas; Conroy, Michael; Kickbusch, Tracey; Mazone, Rebecca


    Distributed Visualization allows anyone, anywhere to see any simulation at any time. Development focuses on algorithms, software, data formats, data systems and processes to enable sharing simulation-based information across temporal and spatial boundaries without requiring stakeholders to possess highly-specialized and very expensive display systems. It also introduces abstraction between the native and shared data, which allows teams to share results without giving away proprietary or sensitive data. The initial implementation of this capability is the Distributed Observer Network (DON) version 3.1. DON 3.1 is available for public release in the NASA Software Store ( and works with version 3.0 of the Model Process Control specification (an XML Simulation Data Representation and Communication Language) to display complex graphical information and associated Meta-Data.

  20. Aluminum corrosion product release kinetics

    Edwards, Matt, E-mail:; Semmler, Jaleh; Guzonas, Dave; Chen, Hui Qun; Toor, Arshad; Hoendermis, Seanna


    Highlights: • Release of Al corrosion product was measured in simulated post-LOCA sump solutions. • Increased boron was found to enhance Al release kinetics at similar pH. • Models of Al release as functions of time, temperature, and pH were developed. - Abstract: The kinetics of aluminum corrosion product release was examined in solutions representative of post-LOCA sump water for both pressurized water and pressurized heavy-water reactors. Coupons of AA 6061 T6 were exposed to solutions in the pH 7–11 range at 40, 60, 90 and 130 °C. Solution samples were analyzed by inductively coupled plasma atomic emission spectroscopy, and coupon samples were analyzed by secondary ion mass spectrometry. The results show a distinct “boron effect” on the release kinetics, expected to be caused by an increase in the solubility of the aluminum corrosion products. New models were developed to describe both sets of data as functions of temperature, time, and pH (where applicable)