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Sample records for rele controls relbe

Messenger RNA Interferase RelE Controls relBE Transcription by Conditional Cooperativity

DEFF Research Database (Denmark)

Overgaard, Martin; Borch, Jonas; Jørgensen, Mikkel G

2008-01-01

Prokaryotic toxin-antitoxin (TA) loci consist of two genes in an operon that encodes a metabolically stable toxin and an unstable antitoxin. The antitoxin neutralises its cognate toxin by forming a tight complex with it. In all cases known, the antitoxin autoregulates TA operon transcription by b...... operator DNA. A mutational analysis of the operator-sites showed that RelE in excess counteracted cooperative binding of the RelB(2)*RelE complexes to the operator-sites. Thus, RelE controls relBE transcription by conditional cooperativity.......Prokaryotic toxin-antitoxin (TA) loci consist of two genes in an operon that encodes a metabolically stable toxin and an unstable antitoxin. The antitoxin neutralises its cognate toxin by forming a tight complex with it. In all cases known, the antitoxin autoregulates TA operon transcription...... by binding to one or more operators in the promoter region while the toxin functions as a co-repressor of transcription. Interestingly, the toxin can also stimulate TA operon transcription. Here we analyse mechanistic aspects of how RelE of Escherichia coli can function both as a co-repressor and derepressor...
RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via The Ribbon-Helix-Helix Motif in RelB

DEFF Research Database (Denmark)

Overgaard, Martin; Borch, Jonas; Gerdes, Kenn

2009-01-01

RelB, the Ribbon-Helix-Helix (RHH) repressor encoded by the relBE toxin-antitoxin locus of Escherichia coli, forms a tight complex with RelE and thereby counteracts the mRNA cleavage activity of RelE. In addition, RelB dimers repress the strong relBE promoter and this repression by RelB is enhanced...... by RelE - that is - RelE functions as a transcriptional co-repressor. RelB is a Lon protease substrate and Lon is required both for activation of relBE transcription and for activation of the mRNA cleavage activity of RelE. Here we characterize the molecular interactions important for transcriptional...... motif recognizes four 6 bp repeats within the bipartite binding site. The spacing between each half-site was found to be essential for cooperative interactions between adjacently bound RelB dimers stabilized by the co-repressor RelE. Kinetic and stoichiometric measurements of the interaction between Rel...
Structural studies of the toxin-antitoxin proteins RelE and RelB from E. coli

DEFF Research Database (Denmark)

Andersen, Kasper Røjkjær; Overgaard, Martin; Gerdes, Kenn

the special tRNA-mRNA mimic, tmRNA [1]. Questions to be addressed Many questions remain to be answered in the bacterial toxin-antitoxin system. The crystal structure of RelBE from Pyrococcus horikoshii OT3 was previously solved at 2.3Å [2]. This structure shows the molecule in an inactive state, but OT3......The bacterial toxin-antitoxin system The relBE operon in E. coli encodes two small proteins: A toxin, RelE (12 kDa) and an antitoxin, RelB (9 kDa). RelE is activated under nutritional stress and is able to inhibit protein synthesis by cleaving the mRNA in the ribosomal A-site. This stress response...... serves to down-regulate metabolism in the cell when growth conditions are limited. RelB is expressed in excess over RelE during balanced growth, and inhibits the toxicity of RelE by forming an extremely stable toxin-antitoxin complex. The activation of RelE is induced when the labile RelB protein...
Bacterial toxin-antitoxin gene system as containment control in yeast cells

DEFF Research Database (Denmark)

Kristoffersen, P.; Jensen, G. B.; Gerdes, K.

2000-01-01

The potential of a bacterial toxin-antitoxin gene system for use in containment control in eukaryotes was explored. The Escherichia coli relE and relB genes were expressed in the yeast Saccharomyces cerevisiae, Expression of the relE gene was highly toxic to yeast cells. However, expression...... fermentation processes in which the escape of genetically modified cells would be considered highly risky....
Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions

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Véronique Baud

2016-05-01

Full Text Available The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development. Beyond the classical NF-κB activation pathway, a second NF-κB pathway has more recently been uncovered, the so-called alternative NF-κB activation pathway. It has been shown that this pathway mainly controls the activity of RelB, a member of the NF-κB family. Post-translational modifications, such as phosphorylation, acetylation, methylation, ubiquitination and SUMOylation, have recently emerged as a strategy for the fine-tuned regulation of NF-κB. Our review discusses recent progress in the understanding of RelB regulation by post-translational modifications and the associated functions in normal and pathological conditions.
PERMODELAN KURVA KARAKTERISTIK INVERSE NON-STANDART PADA RELE ARUS LEBIH DENGAN METODE ADAPTIVE NEURO FUZZY INFERENCE SYSTEM (ANFIS

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Erhankana Ardiana Putra

2017-01-01

Full Text Available Pada sistem kelistrikan terutama pada sistem proteksi kelistrikan dewasa ini sangat dibutuhkan sistem yang handal, sehingga perkembangan pada sistem proteksi sudah semakin maju dengan adanya penggunaan rele digital. Rele digital digunakan dengan mempertimbangkan kecepatan, keakuratan dan serta flexible dalam sistem koordinasi. Flexibilitas ini dimaksudkan bahwa rele digital dapat digunakan menjadi rele arus lebih (overcurrent relay sesuai pembahasan tugas akhir ini dan dapat disetting menurut keinginan user sesuai karakteristik kurva OCR konvensional/standart (normal inverse, very inverse, long time inverse, extreme inverse yang akan digunakan dalam koordinasi. Jenis kurva pada rele digital juga dapat disetting diluar rumus kurva konvensional/standart yang seperti sudah disebutkan sebelumnya, kurva diluar rumusan standart disebut kurva rele non-standart. Kurva rele non-standart digunakan untuk memudahkan pengguna untuk menentukan waktu trip berdasarkan arus yang diinginkan dan sebagai solusi jika pada koordinasi proteksi mengalami kendala dalam koordinasi kurva rele. Pada tugas akhir ini akan dibahas bagaimana membuat atau memodelkan kurva karakteristik inverse overcurrent rele non-standart dengan menggunakan metode (Adaptive Neuro Fuzzy Inference System atau biasa disebut metode pembelajaran ANFIS. Kurva non-standart didapatkan dengan pengambilan titik-titik data baru berupa arus dan waktu trip sesuai keinginan user. Data baru tersebut akan digabungkan dengan data lama sehingga menghasilkan data non-standart yang nantinya akan dilakukan pembelajaran dengan metode ANFIS untuk mendapatkan desain kurva non-standart. Setelah didapatkan desain kurva non-standart akan dilakukan pengujian keakuratan dengan mengganti nilai MF (membership function didapatkan hasil rata-rata error terkecil 2,56% (MF=10 dan epoch=100. Pengujian selanjutnya dengan mengubah nilai epoch didapatkan nilai keakuratan dengan error terkecil pada epoch = 500. Simulasi pada
RNA decay by messenger RNA interferases

DEFF Research Database (Denmark)

Christensen-Dalsgaard, Mikkel; Overgaard, Martin; Winther, Kristoffer Skovbo

2008-01-01

Two abundant toxin-antitoxin (TA) gene families, relBE and mazEF, encode mRNA cleaving enzymes whose ectopic overexpression abruptly inhibits translation and thereby induces a bacteriostatic condition. Here we describe and discuss protocols for the overproduction, purification, and analysis of mR...... cleaving enzymes such as RelE of Escherichia coli and the corresponding antitoxin RelB. In particular, we describe a set of plasmid vectors useful for the detailed analysis of cleavage sites in model mRNAs.......Two abundant toxin-antitoxin (TA) gene families, relBE and mazEF, encode mRNA cleaving enzymes whose ectopic overexpression abruptly inhibits translation and thereby induces a bacteriostatic condition. Here we describe and discuss protocols for the overproduction, purification, and analysis of mRNA...
The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates.

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Concha Nieto

2010-06-01

Full Text Available Type II (proteic chromosomal toxin-antitoxin systems (TAS are widespread in Bacteria and Archaea but their precise function is known only for a limited number of them. Out of the many TAS described, the relBE family is one of the most abundant, being present in the three first sequenced strains of Streptococcus pneumoniae (D39, TIGR4 and R6. To address the function of the pneumococcal relBE2Spn TAS in the bacterial physiology, we have compared the response of the R6-relBE2Spn wild type strain with that of an isogenic derivative, Delta relB2Spn under different stress conditions such as carbon and amino acid starvation and antibiotic exposure. Differences on viability between the wild type and mutant strains were found only when treatment directly impaired protein synthesis. As a criterion for the permanence of this locus in a variety of clinical strains, we checked whether the relBE2Spn locus was conserved in around 100 pneumococcal strains, including clinical isolates and strains with known genomes. All strains, although having various types of polymorphisms at the vicinity of the TA region, contained a functional relBE2Spn locus and the type of its structure correlated with the multilocus sequence type. Functionality of this TAS was maintained even in cases where severe rearrangements around the relBE2Spn region were found. We conclude that even though the relBE2Spn TAS is not essential for pneumococcus, it may provide additional advantages to the bacteria for colonization and/or infection.
The NF-κB family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts.

Science.gov (United States)

Zago, Michela; Rico de Souza, Angela; Hecht, Emelia; Rousseau, Simon; Hamid, Qutayba; Eidelman, David H; Baglole, Carolyn J

2014-04-21

Diseases due to cigarette smoke exposure, including chronic obstructive pulmonary disease (COPD) and lung cancer, are associated with chronic inflammation typified by the increased expression of cyclooxygenase-2 (COX-2) protein. RelB is an NF-κB family member that suppresses cigarette smoke induction of COX-2 through an unknown mechanism. The ability of RelB to regulate COX-2 expression may be via miR-146a, a miRNA that attenuates COX-2 in lung fibroblasts. In this study we tested whether RelB attenuation of cigarette smoke-induced COX-2 protein is due to miR-146a. Utilizing pulmonary fibroblasts deficient in RelB expression, together with siRNA knock-down of RelB, we show the essential role of RelB in diminishing smoke-induced COX-2 protein expression despite robust activation of the canonical NF-κB pathway and subsequent induction of Cox-2 mRNA. RelB did not regulate COX-2 protein expression at the level of mRNA stability. Basal levels of miR-146a were significantly lower in Relb-deficient cells and cigarette smoke increased miR-146a expression only in Relb-expressing cells. Inhibition of miR-146a had no effects on Relb expression or induction of Cox-2 mRNA by cigarette smoke but significantly increased COX-2 protein. These data highlight the potential of a RelB-miR-146a axis as a novel regulatory pathway that attenuates inflammation in response to respiratory toxicants. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
RelB+ Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3+ Regulatory T Cells

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Anja Döhler

2017-06-01

Full Text Available Thymus-derived natural Foxp3+ CD4+ regulatory T cells (nTregs play a key role in maintaining immune tolerance and preventing autoimmune disease. Several studies indicate that dendritic cells (DCs are critically involved in the maintenance and proliferation of nTregs. However, the mechanisms how DCs manage to keep the peripheral pool at constant levels remain poorly understood. Here, we describe that the NF-κB/Rel family transcription factor RelB controls the frequencies of steady-state migratory DCs (ssmDCs in peripheral lymph nodes and their numbers control peripheral nTreg homeostasis. DC-specific RelB depletion was investigated in CD11c-Cre × RelBfl/fl mice (RelBDCko, which showed normal frequencies of resident DCs in lymph nodes and spleen while the subsets of CD103− Langerin− dermal DCs (dDCs and Langerhans cells but not CD103+ Langerin+ dDC of the ssmDCs in skin-draining lymph nodes were increased. Enhanced frequencies and proliferation rates were also observed for nTregs and a small population of CD4+ CD44high CD25low memory-like T cells (Tml. Interestingly, only the Tml but not DCs showed an increase in IL-2-producing capacity in lymph nodes of RelBDCko mice. Blocking of IL-2 in vivo reduced the frequency of nTregs but increased the Tml frequencies, followed by a recovery of nTregs. Taken together, by employing RelBDCko mice with increased frequencies of ssmDCs our data indicate a critical role for specific ssmDC subsets for the peripheral nTreg and IL-2+ Tml frequencies during homeostasis.
Russell Crowe maailma tipust maailma äärele / Timo Diener

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Diener, Timo

2003-01-01

Näitleja Russell Crowe ja tema suhe oma rolliga seiklusfilmis "Kapten ja komandör : retk maailma äärele" ("Master and Commander : The Far Side of the World") : stsenarist Patrick O'Briani romaanide järgi ja režissöör Peter Weir : peaosas Russell Crowe : Ameerika Ühendriigid 2003
Alterations in the expression of the NF-κB family member RelB as a novel marker of cardiovascular outcomes during acute exacerbations of chronic obstructive pulmonary disease.

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Laura Labonté

Full Text Available Chronic obstructive pulmonary disease (COPD exacerbations are acute events of worsened respiratory symptoms and enhanced inflammation partly mediated by NF-κB activation. RelB, an NF-κB family member, suppresses cigarette smoke-induced inflammation but its expression in COPD is unknown. Moreover, there is no information on its association with clinical features of COPD. The objectives of this study were to assess RelB expression relative to markers of inflammation as well as its association with cardiovascular and pulmonary features of COPD patients at stable-state and exacerbation.Data from 48 COPD patients were analyzed. Blood samples were collected from stable-state and exacerbating patients. After RNA isolation, quantitative real-time polymerase chain reaction (qRT-PCR was performed to assess RelB, Cox-2, IL-8 and IL-1β mRNA expression and their associations with measured clinical variables.Of the 48 COPD subjects, 18 were in stable-state and 30 were in exacerbation. RelB mRNA expression was lower than that of Cox-2, IL-8, and IL-1β in all cases (all p<0.001, except for IL-8 at exacerbation (p = 0.22. Cox-2, IL-8 and IL-1β were significantly associated with clinical features of patients in both stable-state and at exacerbation. There was no association with RelB expression and any clinical features in COPD subjects at stable-state. RelB mRNA levels were significantly associated with cardiovascular events such as systolic blood pressure during exacerbation.RelB mRNA expression is lower than that of the other inflammatory mediators. Expression of Cox-2, IL-8 and IL-1β were related to clinical features in both stable-state and at exacerbation. However, RelB expression was associated with clinical features of patients only during exacerbation, suggesting that RelB may represent a novel marker of health outcomes, in particular cardiovascular, during exacerbation in COPD.
Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

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Keogh, Ciara E; Scholz, Carsten C; Rodriguez, Javier; Selfridge, Andrew C; von Kriegsheim, Alexander; Cummins, Eoin P

2017-07-07

CO 2 is a physiological gas normally produced in the body during aerobic respiration. Hypercapnia (elevated blood pCO 2 >≈50 mm Hg) is a feature of several lung pathologies, e.g. chronic obstructive pulmonary disease. Hypercapnia is associated with increased susceptibility to bacterial infections and suppression of inflammatory signaling. The NF-κB pathway has been implicated in these effects; however, the molecular mechanisms underpinning cellular sensitivity of the NF-κB pathway to CO 2 are not fully elucidated. Here, we identify several novel CO 2 -dependent changes in the NF-κB pathway. NF-κB family members p100 and RelB translocate to the nucleus in response to CO 2 A cohort of RelB protein-protein interactions ( e.g. with Raf-1 and IκBα) are altered by CO 2 exposure, although others are maintained ( e.g. with p100). RelB is processed by CO 2 in a manner dependent on a key C-terminal domain located in its transactivation domain. Loss of the RelB transactivation domain alters NF-κB-dependent transcriptional activity, and loss of p100 alters sensitivity of RelB to CO 2 Thus, we provide molecular insight into the CO 2 sensitivity of the NF-κB pathway and implicate altered RelB/p100-dependent signaling in the CO 2 -dependent regulation of inflammatory signaling. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB

International Nuclear Information System (INIS)

Zhang, Shaojie; Patel, Ananddeep; Chu, Chun; Jiang, Weiwu; Wang, Lihua; Welty, Stephen E.; Moorthy, Bhagavatula; Shivanna, Binoy

2015-01-01

Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. Activation of the aryl hydrocarbon receptor (AhR) protects adult and newborn mice against hyperoxic lung injury by mediating increases in the expression of phase I (cytochrome P450 (CYP) 1A) and phase II (NADP(H) quinone oxidoreductase (NQO1)) antioxidant enzymes (AOE). AhR positively regulates the expression of RelB, a component of the nuclear factor-kappaB (NF-κB) protein that contributes to anti-inflammatory processes in adult animals. Whether AhR regulates the expression of AOE and RelB, and protects fetal primary human lung cells against hyperoxic injury is unknown. Therefore, we tested the hypothesis that AhR-deficient fetal human pulmonary microvascular endothelial cells (HPMEC) will have decreased RelB activation and AOE, which will in turn predispose them to increased oxidative stress, inflammation, and cell death compared to AhR-sufficient HPMEC upon exposure to hyperoxia. AhR-deficient HPMEC showed increased hyperoxia-induced reactive oxygen species (ROS) generation, cleavage of poly(ADP-ribose) polymerase (PARP), and cell death compared to AhR-sufficient HPMEC. Additionally, AhR-deficient cell culture supernatants displayed increased macrophage inflammatory protein 1α and 1β, indicating a heightened inflammatory state. Interestingly, loss of AhR was associated with a significantly attenuated CYP1A1, NQO1, superoxide dismutase 1(SOD1), and nuclear RelB protein expression. These findings support the hypothesis that decreased RelB activation and AOE in AhR-deficient cells is associated with increased hyperoxic injury compared to AhR-sufficient cells. - Highlights: • AhR deficiency potentiates oxygen toxicity in human fetal lung cells. • Deficient AhR signaling increases hyperoxia-induced cell death. • AhR deficiency increases hyperoxia-induced ROS generation and inflammation. • Anti-oxidant enzyme levels are attenuated in AhR-deficient lung cells
Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB

Energy Technology Data Exchange (ETDEWEB)

Zhang, Shaojie; Patel, Ananddeep; Chu, Chun; Jiang, Weiwu; Wang, Lihua; Welty, Stephen E.; Moorthy, Bhagavatula; Shivanna, Binoy, E-mail: shivanna@bcm.edu

2015-07-15

Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. Activation of the aryl hydrocarbon receptor (AhR) protects adult and newborn mice against hyperoxic lung injury by mediating increases in the expression of phase I (cytochrome P450 (CYP) 1A) and phase II (NADP(H) quinone oxidoreductase (NQO1)) antioxidant enzymes (AOE). AhR positively regulates the expression of RelB, a component of the nuclear factor-kappaB (NF-κB) protein that contributes to anti-inflammatory processes in adult animals. Whether AhR regulates the expression of AOE and RelB, and protects fetal primary human lung cells against hyperoxic injury is unknown. Therefore, we tested the hypothesis that AhR-deficient fetal human pulmonary microvascular endothelial cells (HPMEC) will have decreased RelB activation and AOE, which will in turn predispose them to increased oxidative stress, inflammation, and cell death compared to AhR-sufficient HPMEC upon exposure to hyperoxia. AhR-deficient HPMEC showed increased hyperoxia-induced reactive oxygen species (ROS) generation, cleavage of poly(ADP-ribose) polymerase (PARP), and cell death compared to AhR-sufficient HPMEC. Additionally, AhR-deficient cell culture supernatants displayed increased macrophage inflammatory protein 1α and 1β, indicating a heightened inflammatory state. Interestingly, loss of AhR was associated with a significantly attenuated CYP1A1, NQO1, superoxide dismutase 1(SOD1), and nuclear RelB protein expression. These findings support the hypothesis that decreased RelB activation and AOE in AhR-deficient cells is associated with increased hyperoxic injury compared to AhR-sufficient cells. - Highlights: • AhR deficiency potentiates oxygen toxicity in human fetal lung cells. • Deficient AhR signaling increases hyperoxia-induced cell death. • AhR deficiency increases hyperoxia-induced ROS generation and inflammation. • Anti-oxidant enzyme levels are attenuated in AhR-deficient lung cells
Structural and thermodynamic characterization of the Escherichia coli RelBE toxin-antitoxin system: indication for a functional role of differential stability

DEFF Research Database (Denmark)

Cherny, Izhack; Overgaard, Martin; Borch, Jonas

2007-01-01

on the folding and stability of the protein pair in solution. Here we structurally and thermodynamically characterize the RelBE system components from E. coli in solution, both separately and in their complexed state. The RelB antitoxin, an alpha-helical protein according to circular dichroism and infrared.......5 degrees C, and exhibits exceptional sensitivity to heat. Complex formation, accompanied by a structural transition, leads to a 12 degrees C increase in the TM and substantial heat resistance. Moreover, in vivo interaction and protein footprint experiments indicate that the C-terminal part of Rel...
Prototipe Rele Proteksi Overheating pada Motor 1 Phasa Berbasis Mikrokontroler AT89C51

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Endi Permata

2016-03-01

Full Text Available Rele proteksi panas berlebih berbasis mikrokontroler AT89S51 merupakan suatu alat yang digunakan untuk memproteksi motor agar tidak terjadinya kerusakan pada motor. Pada penelitian ini dibuat prototipe rele proteksi panas berlebih pada motor 1 phasa berbasis mikrokontroler AT89S51 berdasarkan kelas isolator yang dipakai pada motor yaitu Y dan A dengan sistem pengendalinya adalah miukrokontroler AT89C51. Mikrokontroler AT89C51 sebagai pengendali dari piranti – piranti lain yang digunakan seperti sensor suhu LM35, Op-Amp, dan ADC, apabila suhu yang terdeteksi oleh sensor tidak sesuai dengan penyetingan batasnya tersebut maka mikrokontroler AT89C51 memerintahkan ke relay 12 Vdc untuk membunyikan alarm dan juga menghidupkan kontaktor yang terhubung ke motor. Sehingga Motor terselamatkan dari gangguan panas berlebih yang dapat menyebabkan motor terbakar. Adapun untuk mengetahui pada suhu berapa terjadinya gangguan pada motor ditampilkan melalui display LCD 16x2.
Analisis Koordinasi Rele Arus Lebih Dan Penutup Balik Otomatis (Recloser) Pada Penyulang J

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Ir. Teguh Utomo, M.T., Mega Firdausi., Ir. Hery Purnomo ,M.T

2015-01-01

Di dalam jaringan distribusi 20 kV sering terjadi gangguang, salah satunya adalah gangguan arus hubung singkat. Dalam mengatasi gangguan arus hubung singkat ini diperlukan koordinasi antar pengaman jaringan distribusi agar dapat mengisolasi gangguan dan melindungi jaringan distribusi serta perlatan yang berada di jaringan tersebut. Koordinasi antara Penutup Balik Otomatis (Recloser) sebagai pengaman utama dengan Rele arus lebih baik pada sisi penyulang maupun masukan 20 kV sebagai pengaman ca...
ReleQuant – Improving teaching and learning in quantum physics through educational design research

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Berit Bungum

2015-05-01

Full Text Available Quantum physics and relativity are demanding for teachers and students, but have the potential for students to experience physics as fascinating and meaningful. Project ReleQuant engaged in educational design research to improve teaching and learning in these topics in Norwegian upper secondary schools. The paper focuses on the first cycle of development of a teaching module on quantum physics and how design principles were developed. We construct the design principles by reviewing relevant research literature and conducting three pilot studies. The process resulted in the following principles for designing the quantum physics teaching module: 1 clarify how quantum physics breaks with classical physics; 2 use simulations of phenomena that cannot be experienced directly; 3 provide students to use written and oral language; 4 address and discuss wave-particle duality and the uncertainty
Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome

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Marchesi Julian R

2010-01-01

Full Text Available Abstract Background Little is known regarding the pool of mobile genetic elements associated with the human gut microbiome. In this study we employed the culture independent TRACA system to isolate novel plasmids from the human gut microbiota, and a comparative metagenomic analysis to investigate the distribution and relative abundance of functions encoded by these plasmids in the human gut microbiome. Results Novel plasmids were acquired from the human gut microbiome, and homologous nucleotide sequences with high identity (>90% to two plasmids (pTRACA10 and pTRACA22 were identified in the multiple human gut microbiomes analysed here. However, no homologous nucleotide sequences to these plasmids were identified in the murine gut or environmental metagenomes. Functions encoded by the plasmids pTRACA10 and pTRACA22 were found to be more prevalent in the human gut microbiome when compared to microbial communities from other environments. Among the most prevalent functions identified was a putative RelBE toxin-antitoxin (TA addiction module, and subsequent analysis revealed that this was most closely related to putative TA modules from gut associated bacteria belonging to the Firmicutes. A broad phylogenetic distribution of RelE toxin genes was observed in gut associated bacterial species (Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria, but no RelE homologues were identified in gut associated archaeal species. We also provide indirect evidence for the horizontal transfer of these genes between bacterial species belonging to disparate phylogenetic divisions, namely Gram negative Proteobacteria and Gram positive species from the Firmicutes division. Conclusions The application of a culture independent system to capture novel plasmids from the human gut mobile metagenome, coupled with subsequent comparative metagenomic analysis, highlighted the unexpected prevalence of plasmid encoded functions in the gut microbial ecosystem. In

TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21.

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Ana B Sanz

2010-01-01

Full Text Available TWEAK is a member of the TNF superfamily of cytokines that contribute to kidney tubulointerstitial injury. It has previously been reported that TWEAK induces transient nuclear translocation of RelA and expression of RelA-dependent cytokines in renal tubular cells. Additionally, TWEAK induced long-lasting NFkappaB activation suggestive of engagement of the non-canonical NFkappaB pathway. We now explore TWEAK-induced activation of NFkappaB2 and RelB, as well as expression of CCL21, a T-cell chemotactic factor, in cultured murine tubular epithelial cells and in healthy kidneys in vivo. In cultured tubular cells, TWEAK and TNFalpha activated different DNA-binding NFkappaB complexes. TWEAK-induced sustained NFkappaB activation was associated with NFkappaB2 p100 processing to p52 via proteasome and nuclear translocation and DNA-binding of p52 and RelB. TWEAK, but not TNFalpha used as control, induced a delayed increase in CCL21a mRNA (3.5+/-1.22-fold over control and CCL21 protein (2.5+/-0.8-fold over control, which was prevented by inhibition of the proteasome, or siRNA targeting of NIK or RelB, but not by RelA inhibition with parthenolide. A second NFkappaB2-dependent chemokine, CCL19, was upregulates by TWEAK, but not by TNFalpha. However, both cytokines promoted chemokine RANTES expression (3-fold mRNA at 24 h. In vivo, TWEAK induced nuclear NFkappaB2 and RelB translocation and CCL21a mRNA (1.5+/-0.3-fold over control and CCL21 protein (1.6+/-0.5-fold over control expression in normal kidney. Increased tubular nuclear RelB and tubular CCL21 expression in acute kidney injury were decreased by neutralization (2+/-0.9 vs 1.3+/-0.6-fold over healthy control or deficiency of TWEAK (2+/-0.9 vs 0.8+/-0.6-fold over healthy control. Moreover, anti-TWEAK treatment prevented the recruitment of T cells to the kidney in this model (4.1+/-1.4 vs 1.8+/-1-fold over healthy control. Our results thus identify TWEAK as a regulator of non-canonical NFkappa
Regulation of development and function of different T cell subtypes by Rel/NF-κB family members

International Nuclear Information System (INIS)

Vallabhapurapu, S.

2004-09-01

This study reveals the requirement of distinct members of the Rel/NF-κB family in both hematopoietic and non-hematopoietic cells for the development of thymic NKT cells. Activation of NF-κB via the classical IκBα-regulated pathway is required within the NKT precursors for their efficient maturation from NK1.1 - precursors to mature NK1.1 + NKT cells. The Rel/NF-κB family member RelB, on the other hand, is required in thymic stromal cells for the generation of very early NK1.1 - precursors. NF-κB-inducing kinase (NIK) has also been shown to be required in thymic stromal cells for NKT cell development and this study demonstrates that NIK specifically regulates both constitutive and signal-induced DNA binding of RelB, but not RelA. Moreover, NIK-induced DNA binding of RelB depends on the processing of inhibitory p100 to p52, revealing an alternate pathway of NF-κB induction. Thus, Rel/NF-κB complexes activated by the classical IκBα-regulated pathway in NKT precursors and an alternate NIK/p100/RelB pathway in thymic stromal cells regulate different stages of NKT cell development. (orig.)
Regulation of development and function of different T cell subtypes by Rel/NF-{kappa}B family members

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Vallabhapurapu, S.

2004-09-01

This study reveals the requirement of distinct members of the Rel/NF-{kappa}B family in both hematopoietic and non-hematopoietic cells for the development of thymic NKT cells. Activation of NF-{kappa}B via the classical I{kappa}B{alpha}-regulated pathway is required within the NKT precursors for their efficient maturation from NK1.1{sup -} precursors to mature NK1.1{sup +} NKT cells. The Rel/NF-{kappa}B family member RelB, on the other hand, is required in thymic stromal cells for the generation of very early NK1.1{sup -} precursors. NF-{kappa}B-inducing kinase (NIK) has also been shown to be required in thymic stromal cells for NKT cell development and this study demonstrates that NIK specifically regulates both constitutive and signal-induced DNA binding of RelB, but not RelA. Moreover, NIK-induced DNA binding of RelB depends on the processing of inhibitory p100 to p52, revealing an alternate pathway of NF-{kappa}B induction. Thus, Rel/NF-{kappa}B complexes activated by the classical I{kappa}B{alpha}-regulated pathway in NKT precursors and an alternate NIK/p100/RelB pathway in thymic stromal cells regulate different stages of NKT cell development. (orig.)
The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.

Science.gov (United States)

Grinberg-Bleyer, Yenkel; Caron, Rachel; Seeley, John J; De Silva, Nilushi S; Schindler, Christian W; Hayden, Matthew S; Klein, Ulf; Ghosh, Sankar

2018-04-01

CD4 + Foxp3 + regulatory T cells (Tregs) are essential regulators of immune responses. Perturbation of Treg homeostasis or function can lead to uncontrolled inflammation and autoimmunity. Therefore, understanding the molecular mechanisms involved in Treg biology remains an active area of investigation. It has been shown previously that the NF-κB family of transcription factors, in particular, the canonical pathway subunits, c-Rel and p65, are crucial for the development, maintenance, and function of Tregs. However, the role of the alternative NF-κB pathway components, p100 and RelB, in Treg biology remains unclear. In this article, we show that conditional deletion of the p100 gene, nfkb2 , in Tregs, resulted in massive inflammation because of impaired suppressive function of nfkb2 -deficient Tregs. Surprisingly, mice lacking RelB in Tregs did not exhibit the same phenotype. Instead, deletion of both relb and nfkb2 rescued the inflammatory phenotype, demonstrating an essential role for p100 as an inhibitor of RelB in Tregs. Our data therefore illustrate a new role for the alternative NF-κB signaling pathway in Tregs that has implications for the understanding of molecular pathways driving tolerance and immunity. Copyright © 2018 by The American Association of Immunologists, Inc.
Kullapalavik naftaturul / Tõnis Oja

Index Scriptorium Estoniae

Oja, Tõnis, 1957-

2006-01-01

Ilmunud ka: Delovõje Vedomosti 26. apr. lk. 25. Nafta hinna seitsmekordne tõus seitsme aasta jooksul on tingitud mitte niivõrd nõudlusest füüsilise nafta järele, vaid nõudlusest nafta kui investeerimisobjekti ehk virtuaalnafta järele. Vt. samas: Toormehinna lagi on üsna madal
Lääne-Euroopa kaotab idale / Hans-Werner Sinn

Index Scriptorium Estoniae

Sinn, Hans-Werner, 1948-

2007-01-01

Ilmunud ka: Molodjozh Estonii 9. märts lk. 8. EL-i laienemine itta tähendab tööjõuturu jaoks seda, et nõudlus kõrgelt kvalifitseeritud Lääne-Euroopa tööjõu järele suureneb, kõigi teiste tööliste järele aga langeb ning kokkuvõttes töökohtade arv Lääne-Euroopas väheneb
Near-real time forecasts of MeV protons based on sub-relativistic electrons: communicating the outputs to the end users

Science.gov (United States)

Sarlanis, Christos; Heber, Bernd; Labrenz, Johannes; Kühl, Patrick; Marquardt, Johannes; Dimitroulakos, John; Papaioannou, Athanasios; Posner, Arik

2017-04-01

Solar Energetic Particle (SEP) events are one of the most important elements of space weather. Given that the complexity of the underlying physical processes of the acceleration and propagation of SEP events is still a very active research area, the prognosis of SEP event occurrence and their corresponding characteristics remains challenging. In order to provide up to an hour warning time before these particles arrive at Earth, relativistic electron and below 50 MeV proton data from the Electron Proton Helium Instrument (EPHIN) on SOHO were used to implement the 'Relativistic Electron Alert System for Exploration (REleASE)'. The REleASE forecasting scheme was recently rewritten in the open access programming language PYTHON and will be made publicly available. As a next step, along with relativistic electrons (v > 0.9 c) provided by SOHO, near-relativistic (v work, we demonstrate the real-time outputs derived by the end user from the REleASE using both SOHO/EPHIN and ACE/EPAM. We further, show a user friendly illustration of the outputs that make use of a "traffic light" to monitor the different warning stages: quiet, warning, alert offering a simple guidance to the end users. Finally, the capabilities offered by this new system, accessing both the pictorial and textural outputs REleASE are being presented. This work has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 637324.
Prevalence of plasmid genetic elements among ESBL-producing E. coli isolated from a UK river and the effects of waste water effluent release

OpenAIRE

Dinatale, Adam

2017-01-01

The global antibiotic resistance crisis is a growing issue which poses a significant threat to human and animal health, and will limit the effectiveness of infection treatment in clinical settings. Traditionally research efforts have concentrated on discovering novel antibiotics, however an alternative approach is being utilised which focuses on the control and removal of antibiotic resistance from the environment. A major source of environmental antibiotic resistance originates from the rele...
Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon.

Science.gov (United States)

Chan, Wai Ting; Yeo, Chew Chieng; Sadowy, Ewa; Espinosa, Manuel

2014-01-01

Bacterial toxin-antitoxin (TAs) loci usually consist of two genes organized as an operon, where their products are bound together and inert under normal conditions. However, under stressful circumstances the antitoxin, which is more labile, will be degraded more rapidly, thereby unleashing its cognate toxin to act on the cell. This, in turn, causes cell stasis or cell death, depending on the type of TAs and/or time of toxin exposure. Previously based on in silico analyses, we proposed that Streptococcus pneumoniae, a pathogenic Gram-positive bacterium, may harbor between 4 and 10 putative TA loci depending on the strains. Here we have chosen the pneumococcal strain Hungary(19A)-6 which contains all possible 10 TA loci. In addition to the three well-characterized operons, namely relBE2, yefM-yoeB, and pezAT, we show here the functionality of a fourth operon that encodes the pneumococcal equivalent of the phd-doc TA. Transcriptional fusions with gene encoding Green Fluorescent Protein showed that the promoter was slightly repressed by the Phd antitoxin, and exhibited almost background values when both Phd-Doc were expressed together. These findings demonstrate that phd-doc shows the negative self-regulatory features typical for an authentic TA. Further, we also show that the previously proposed TAs XreA-Ant and Bro-XreB, although they exhibit a genetic organization resembling those of typical TAs, did not appear to confer a functional behavior corresponding to bona fide TAs. In addition, we have also discovered new interesting bioinformatics results for the known pneumococcal TAs RelBE2 and PezAT. A global analysis of the four identified toxins-antitoxins in the pneumococcal genomes (PezAT, RelBE2, YefM-YoeB, and Phd-Doc) showed that RelBE2 and Phd-Doc are the most conserved ones. Further, there was good correlation among TA types, clonal complexes and sequence types in the 48 pneumococcal strains analyzed.
Experiment list: SRX122465 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available 6 || chip antibody=Relb || treatment=LPS || time=120 min || chip antibody manufacturer 1=Bethyl || chip anti...body catalog number 1=A302-183A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2
Experiment list: SRX122466 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available p antibody=Relb || treatment=LPS || time=30 min || chip antibody manufacturer 1=Bethyl || chip antibody cata...log number 1=A302-183A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-226 h
Smokeless tobacco use: A meta-analysis of risk and attributable mortality estimates for India

OpenAIRE

D N Sinha; K M Palipudi; P C Gupta; S Singhal; C Ramasundarahettige; P Jha; A Indrayan; S Asma; G Vendhan

2014-01-01

Background: Use of smokeless tobacco (SLT) is widely prevalent in India and Indian subcontinent. Cohort and case-control studies in India and elsewhere report excess mortality due to its use. Objective: The aim was to estimate the SLT use-attributable deaths in males and females, aged 35 years and older, in India. Materials And Methods: Prevalence of SLT use in persons aged 35 years and older was obtained from the Global Adult Tobacco Survey in India and population size and deaths in the rele...
Legitimacy of private police in developed, emerging, and transitional economies / Mahesh K. Nalla, Sheila R. Maxwell, Chae M. Mamayek

Index Scriptorium Estoniae

Nalla, Mahesh K.

2017-01-01

Elanike madalast usaldusest riigivõimu vastu ja sellest tulenevalt suuremast vajadusest erateenuste järele. Uuringust kõrge ja madala demokraatlikkusega riikidest ning usaldusest erapolitsei ja riiklike turvateenuste vastu
Eestlased väldivad seikluskoolitusel ekstreemsust / Teeli Remmelg

Index Scriptorium Estoniae

Remmelg, Teeli

2005-01-01

OÜ Metaprofit konsultant Alexander Kotchubei, OÜ ATP Koolitus juht Inno Joonas ja Meeskonnatreeningute Keskuse treener Ülo Vihma seikluskoolitusest kui meeskonnakoolituse meetodist ja nõudlusest seikluskoolituse järele Eestis
Terrorizm i elektronnõje SMI / Mihhail Petrov

Index Scriptorium Estoniae

Petrov, Mihhail

2008-01-01

Oktoobri lõpus Küprosel toimunud rahvusvahelisest konverentsist "Terrorism and Electronic Media" võttis osa ka Küprose president Demetris Christofias. Konverentsil selgus vajadus ühtse terminoloogia järele
Conditional Cooperativity in Toxin-Antitoxin Regulation Prevents Random Toxin Activation and Promotes Fast Translational Recovery

DEFF Research Database (Denmark)

Cataudella, Ilaria; Trusina, Ala; Sneppen, Kim

2012-01-01

system, relBE of Escherichia coli. We show that the model with the in vivo and in vitro established parameters reproduces experimentally observed response to nutritional stress. We further demonstrate that conditional cooperativity stabilizes the level of antitoxin in rapidly growing cells...
Põllumajandus tõotamas saaki / Virge Lahe

Index Scriptorium Estoniae

Lahe, Virge

2008-01-01

Investeerimisel on põllumajandussektor kasvav trend. Järgneva 25 aasta jooksul kasvab nõudlus põllumajandustoodete järele keskmiselt 2,5% aastas. Diagramm: Põllumajandussektori aastaindeksite muutus alates 2000. aasta algusest
Bobby heitis Bert Pringile väljakutse / Aigi Viira

Index Scriptorium Estoniae

Viira, Aigi

2004-01-01

Laulja Bert Pringi, kelle kehastada on suur roll Smithbridge Productions uues muusikaliprojektis - George Gershwini "Hull sinu järele", lavastaja Andrus Vaarik. Ka näitleja Andero Ermeli rollist loobumise põhjustest
Kes kardab poeete? / Giuseppe Provenzano ; tõlk. Katrin Tombak

Index Scriptorium Estoniae

Provenzano, Giuseppe

2008-01-01

Tallinna Harjumäele rajatavast Vabaduse monumendist, ummiku äärele jõudnud avalikust diskussioonist, monumendi tähendusest. Õnnestunud monument peab esmajoones puudutama meie hinge ja tal ei tohiks puududa ilu
"Minu veetlev leedi" jääb ära

Index Scriptorium Estoniae

2004-01-01

Smithbridge Productionsi väljakuulutatud muusikali ärajäämisest, 5. nov. Linnahalli lavale jõydvast muusikalist "Hull sinu järele". 2005. a. detsembis etenduvast konkurwndi Tequila muusikalist "Minu veetlev leedi"

Väärikas Estonian Air jäi kampaaniaga hätta / Alyona Stadnik

Index Scriptorium Estoniae

Stadnik, Alyona

2010-01-01

Estonian Air müüs veebikaupluse cherry.ee kaudu soodsaid kinkekaarte. Vastuolu tekkis asjaolust, et nõudlus kinkekaartide järele oli suurem kui pakkumine. Lennukompanii katkestas soodsate kinkekaartide müügi
Kangur Ivan ajab triipu, naised lähevad arust ära / Rein Sikk

Index Scriptorium Estoniae

Sikk, Rein, 1961-

2011-01-01

Ivan Uvarovist, kes koob oma pisikeses töökojas Rakveres rahvarõivamustritega puuvillast triibukangast, mille järele on suur nõudmine. Ivan Uvarov on töötanud 30 aastat kangastelgede mehaanikuna
Bergmann eitab kurikuulsa ERA Panga üldkoosoleku võltsitust / Väinu Rozental

Index Scriptorium Estoniae

Rozental, Väinu, 1957-

2002-01-01

ERA Panga eksjuht Andres Bergmann kinnitas kohtus, et protokoll panga aktsionäride üldkoosoleku kohta, mis vabastas kohustustest panga ees kuus äriühingut ja Tarmo Rubeni, polnud tagantjärele vormistatud
BOOKS I BOEKE

African Journals Online (AJOL)

butions porentially of broad imerest to all medical practi- tioners. ... tures; forensic psychiany; and some issues of special rele- vance to the ... research projects'. The book .... quizzical whimsicality, and endurance, running through the book.
"Die Nato hat einen grossen Fehler begangen" / Toomas Hendrik Ilves ; interv. Ansgar Graw

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2008-01-01

Eesti president räägib sõjalistest kokkupõrgetest Gruusias, vajadusest uue rahvusvahelise julgeolekustruktuuri järele, ootustest rahvusvahelise üldsuse suhtes, Balti riikide julgeolekust ning kritiseerib NATO otsust mitte anda Gruusiale NATO liikmelisuse tegevuskava
"Paratamatus elada ühel ajal" = "Destiny to Live at the Same Time" / Kalle Komissarov

Index Scriptorium Estoniae

Komissarov, Kalle, 1976-

2004-01-01

Avaliku ja privaatse ruumi seotusest ühiskonnakorraldusega. Inimeste eluviisi muutumisest rõhutatult individualiseerituks, nõudlusest erinevate eluruumide järele ja sellest tulenevatest muutustest elamuehituses. Tallinna näitel poolavalikust ruumist, mis ootab alles mõtestamist
Nõukogulik Gruusia annab alla / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2003-01-01

Hääletustulemuste võltsimisest Adzhaarias 2. novembril toimunud parlamendivalimistel. Adzhaaria autonoomne vabariik ei tunnista uut võimu Gruusias. Tagasiastunud presidendi Eduard Shevardnadze lähikond on uuele võimule järele andnud. Lisa: Gruusia
Pandi ja Hanschmidti spaa sai EASilt 10 miljonit krooni / Ralf-Martin Soe

Index Scriptorium Estoniae

Soe, Ralf-Martin

2007-01-01

Ettevõtluse Arendamise Sihtasutus finantseeris 2006. aastal 10 miljoni krooniga Tallinki juhtfiguuride osalusega AS-i Heal uue spaa ehitust Haapsalus. Diagramm: Osalused AS-is Heal. Vt. samas: Kilgile ja Sooäärele samuti 10 miljonit
Põhjalikud muutused = Capital changes / Hans Ibelings

Index Scriptorium Estoniae

Ibelings, Hans, 1963-

2011-01-01

Arhitektuursest arengust Euroopas alates II Maailmasõjast. Viisidest, mil moel erinevad endised sotsialistlikud riigid peale üleminekuperioodi aastatel 1989-1991 läänele järele jõudma hakkasid. Arhitektuurse arengu sarnasusest ja erinevustest postkommunistlikes riikides
Iharus iseenda järele / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2006-01-01

Tutvustus: Gide, André. Surra, et elada / tlk. Leena Tomasberg. Tallinn : Varrak, 2006 ; Soosaar, Martti. Lase vareseid! Tallinn : Tänapäev, 2006 ; Otsides : Juhan Peegel. Meenutusi pikalt teelt / koost. Maarja Lõhmus. Tallinn : Tänapäev, 2006 ; Steffenson, Jakob. Meie, ruhnlased. Tartu : A. Tuulberg, 2006
Ettevaatust, kaitsepolitsei! / Roy Strider

Index Scriptorium Estoniae

Strider, Roy, 1974-

2007-01-01

Ajendatuna anarhistliku liikumise PunaMust meeleavalduse jälgimisest end ajakirjanikuks nimetanud kaitsepolitsei töötaja poolt kirjutab autor kaitsepolitsei mõttetust nuhkimisest oma kodanike järele, mis võib viia jälgimisühiskonnani
Suunad Euroopa kõrghariduses : [avaveerg] / Sirje Virkus

Index Scriptorium Estoniae

Virkus, Sirje, 1956-

2002-01-01

Euroopa kõrgharidust iseloomustab üha suurenev nõudmine elukestva õppimise järele, rahvusvahelise teabeedastuse, hajutatud teaduskeskuste ning IKT osatähtsuse kasv, koostöövõrkude laienemine Euroopas ja kogu maailmas ning kõrghariduse harmoniseerimine
The DinJ/RelE Toxin-Antitoxin System Suppresses Bacterial Proliferation and Virulence of Xylella fastidiosa in Grapevine.

Science.gov (United States)

Burbank, Lindsey P; Stenger, Drake C

2017-04-01

Xylella fastidiosa, the causal agent of Pierce's disease of grapes, is a slow-growing, xylem-limited, bacterial pathogen. Disease progression is characterized by systemic spread of the bacterium through xylem vessel networks, causing leaf-scorching symptoms, senescence, and vine decline. It appears to be advantageous to this pathogen to avoid excessive blockage of xylem vessels, because living bacterial cells are generally found in plant tissue with low bacterial cell density and minimal scorching symptoms. The DinJ/RelE toxin-antitoxin system is characterized here for a role in controlling bacterial proliferation and population size during plant colonization. The DinJ/RelE locus is transcribed from two separate promoters, allowing for coexpression of antitoxin DinJ with endoribonuclease toxin RelE, in addition to independent expression of RelE. The ratio of antitoxin/toxin expressed is dependent on bacterial growth conditions, with lower amounts of antitoxin present under conditions designed to mimic grapevine xylem sap. A knockout mutant of DinJ/RelE exhibits a hypervirulent phenotype, with higher bacterial populations and increased symptom development and plant decline. It is likely that DinJ/RelE acts to prevent excessive population growth, contributing to the ability of the pathogen to spread systemically without completely blocking the xylem vessels and increasing probability of acquisition by the insect vector.
Winners and losers in transition: preferences for redistribution and nostalgia for communism in Eastern Europe / Adam Okulicz- Kozaryn

Index Scriptorium Estoniae

Okulicz- Kozaryn, Adam

2014-01-01

Artikli teema on üleminekuperioodi võitjad ja kaotajad Ida-Euroopas (sh. Eesti), täpsemalt käsitletakse nostalgiat kommunismi järele. Andmed pärinevad uurimusest „Demokraatia konsolideerumine Kesk- ja Ida-Euroopas 1990-2001”.
Max Jakobsoni saatuseaastad, soomlased ja meie / Imbi Paju

Index Scriptorium Estoniae

Paju, Imbi, 1959-

2008-01-01

Soome politoloogist ja diplomaadist Max Jakobsonist ja tema uuest raamatust "Saatuseaastad. Soome tõusis, andis Venemaale järele ja pääses". Artiklis on juttu ka Max Jakobsoni suhetest Eesti presidentide Lennart Meri ja Toomas Hendrik Ilvesega
Teised meist - välise hinnangu otsingul = Others about us - in search of external validation / Toomas Hendrik Ilves

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2008-01-01

Presidendi arvates pööratakse Eestis liiga palju tähelepanu sellele, mida teised meist arvavad ning kuulatakse vähe kaasmaalasi. Eestlaste vajadusest tunnustuse järele ja selle ajaloolistest põhjustest. Valikuvabadusest ja vastutusest demokraatlikus riigis
Hinnad jätkavad tõusu / Kenneth Rogoff

Index Scriptorium Estoniae

Rogoff, Kenneth

2005-01-01

Argentiina majandusteadlase Raul Prebischi sõltuvusteooria kinnitas, et kui vaesed riigid sõltuvad liigselt kaupade ekspordist, ei saavuta nad iial tööstuslikku taset, mida on vaja kiire kasvu säilitamiseks. Vt. samas: Vajadus nafta järele kasvab
Amadiinid võivad luua samasoolise paari

Index Scriptorium Estoniae

2011-01-01

Ajakirjas Behavioural Ecology and Sociobiology ilmunud California Berkeley ülikooli teadlase Julie Elie artiklist, mis võtab kokku katsed sebra-amadiinidega ning kinnitab, et linnud võivad vajadusest hooliva kaaslase järele moodustada ka samasoolisi püsivaid paare
Estonian sugar mountain turns sour / Alec Charles

Index Scriptorium Estoniae

Charles, Alec

2005-01-01

Eesti valitsus jätkab võitlust Euroopa Komisjoniga, et mitte maksta 55 miljonit eurot trahvi suhkru ladustamise eest. Peaminister Juhan Parts saatis Euroopa Komisjoni presidendile Jose Manuel Barrosole kirja, milles palus trahvi nõudmise suhtes järele mõelda.
Solar Particle Radiation Storms Forecasting and Analysis within the Framework of the `HESPERIA' HORIZON 2020 Project

Science.gov (United States)

Posner, A.; Malandraki, O.; Nunez, M.; Heber, B.; Labrenz, J.; Kühl, P.; Milas, N.; Tsiropoula, G.; Pavlos, E.

2017-12-01

Two prediction tools that have been developed in the framework of HESPERIA based upon the proven concepts UMASEP and REleASE. Near-relativistic (NR) electrons traveling faster than ions (30 MeV protons have 0.25c) are used to forecast the arrival of protons of Solar Energetic Particle (SEP) events with real-time measurements of NR electrons. The faster electrons arrive at L1 30 to 90 minutes before the slower protons. REleASE (Relativistic Electron Alert System for Exploration, Posner, 2007) uses this effect to predict the proton flux by utilizing actual electron fluxes and their most recent increases. Through HESPERIA, a clone of REleASE was built in open source programming language. The same forecasting principle was adapted to real-time data from ACE/EPAM. It is shown that HESPERIA REleASE forecasting works with any NR electron flux measurements. >500 MeV solar protons are so energetic that they usually have effects on the ground, producing Ground Level Enhancement (GLE) events. Within HESPERIA, a predictor of >500 SEP proton events near earth (geostationary orbit) has been developed. In order to predict these events, UMASEP (Núñez, 2011, 2015) has been used. UMASEP makes a lag-correlation of solar electromagnetic (EM) flux with the particle flux near earth. If the correlation is high, the model infers that there is a magnetic connection through which particles are arriving. If, additionally, the intensity of the flux of the associated solar event is also high, then UMASEP issues a SEP prediction. In the case of the prediction of >500 MeV SEP events, the implemented system, called HESPERIA UMASEP-500, correlates X-ray flux with differential proton fluxes by GOES, and with fluxes collected by neutron monitor stations around the world. When the correlation estimation and flare surpasses thresholds, a >500 MeV SEP forecast is issued. These findings suggest that a synthesis of the various approaches may improve over the status quo. Both forecasting tools are

HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea

DEFF Research Database (Denmark)

Jørgensen, Mikkel G; Pandey, Deo P; Jaskolska, Milena

2009-01-01

. Expression of HicB (145 aa) prevented HicA-mediated inhibition of cell growth. These results suggest that HicB neutralizes HicA and therefore functions as an antitoxin. As with other antitoxins (RelB and MazF), HicB could resuscitate cells inhibited by HicA, indicating that ectopic production of HicA induces...
A BENCHMARKING ANALYSIS FOR FIVE RADIONUCLIDE VADOSE ZONE MODELS (CHAIN, MULTIMED_DP, FECTUZ, HYDRUS, AND CHAIN 2D) IN SOIL SCREENING LEVEL CALCULATIONS

Science.gov (United States)

Five radionuclide vadose zone models with different degrees of complexity (CHAIN, MULTIMED_DP, FECTUZ, HYDRUS, and CHAIN 2D) were selected for use in soil screening level (SSL) calculations. A benchmarking analysis between the models was conducted for a radionuclide (99Tc) rele...
Rational Choice and the Relevance of Irrelevant Alternatives

NARCIS (Netherlands)

Seidl, C.; Traub, S.

1996-01-01

This experimental study investigates the inuence of irrelevant or phantom al- ternatives on subjects' choices in sequential decision making. Using experimental data from 45 subjects, we found that irrelevant alternatives bear significant rele- vance for decision making. We observe that only 38% of
Me alles hakkame ehitama / Kalev Kallemets

Index Scriptorium Estoniae

Kallemets, Kalev, 1979-

2006-01-01

Ilmunud ka: Delovõje Vedomosti 6. dets. lk. 10. Eesti elamuehituse maht on alles jõudmas Euroopa tasemele ning selleks, et jõuaksime keskmiste eluruumi ruutmeetritega inimese kohta järele arenenud riikidele, kulub veel palju aktiivseid kinnisvara arendamise aastaid, leiab autor
Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice

Directory of Open Access Journals (Sweden)

Sumit Bhattacharyya

2013-01-01

Full Text Available The common food additive carrageenan is a known activator of inflammation in mammalian tissues and stimulates both the canonical and noncanonical pathways of NF-κB activation. Exposure to low concentrations of carrageenan (10 μg/mL in the water supply has produced glucose intolerance, insulin resistance, and impaired insulin signaling in C57BL/6 mice. B-cell leukemia/lymphoma 10 (Bcl10 is a mediator of inflammatory signals from Toll-like receptor (TLR 4 in myeloid and epithelial cells. Since the TLR4 signaling pathway is activated in diabetes and by carrageenan, we addressed systemic and intestinal inflammatory responses following carrageenan exposure in Bcl10 wild type, heterozygous, and null mice. Fecal calprotectin and circulating keratinocyte chemokine (KC, nuclear RelA and RelB, phospho(Thr559-NF-κB-inducing kinase (NIK, and phospho(Ser36-IκBα in the colonic epithelial cells were significantly less (P<0.001 in the carrageenan-treated Bcl10 null mice than in controls. IL-10-deficient mice exposed to carrageenan in a germ-free environment showed an increase in activation of the canonical pathway of NF-κB (RelA activation, but without increase in RelB or phospho-Bcl10, and exogenous IL-10 inhibited only the canonical pathway of NF-κB activation in cultured colonic cells. These findings demonstrate a Bcl10 requirement for maximum development of carrageenan-induced inflammation and lack of complete suppression by IL-10 of carrageenan-induced inflammation.
Clinical examination findings as prognostic factors in low back pain

DEFF Research Database (Denmark)

Hartvigsen, Lisbeth; Kongsted, Alice; Hestbaek, Lise

2015-01-01

BACKGROUND: There is a strong tradition of performing a clinical examination of low back pain (LBP) patients and this is generally recommended in guidelines. However, establishing a pathoanatomic diagnosis does not seem possible in most LBP patients and clinical tests may potentially be more rele...
Nokia liidrikoht surve all / Tõnis Arnover

Index Scriptorium Estoniae

Arnover, Tõnis, 1952-

2003-01-01

Kuigi III kvartali tulemuste alusel on Nokia jätkuvalt turuliider, on tema kasv peatunud ning kiiresti arenevad konkurendid - Sony Ericsson, Motorola ja Siemens seavad ettevõtte positsiooni ohtu. Mobiiltelefonideturule tulemise plaanist on märku andnud ka Microsoft. Diagrammid: Nokia annab järele
Morskije prikljutshenija Rassela Krou / Ilja Svensson

Index Scriptorium Estoniae

Svensson, Ilja

2003-01-01

Seiklusfilm "Kapten ja komandör : retk maailma äärele" ("Master and Commander : The Far Side of the World") : stsenarist Patrick O'Briani romaanide järgi ja režissöör Peter Weir : peaosas Russell Crowe : Ameerika Ühendriigid 2003
Kas New York või põlluriba? / Olev Remsu

Index Scriptorium Estoniae

Remsu, Olev, 1947-

2006-01-01

Autor leiab, et paljud inimesed tunnevad vajadust autoriteedi järele, kellesse nad võiksid uskuda ja kellel oleks ühiskonna üle kindel võim. Eesti poliitikas on olnud ja on kolm isaimidzhiga isiksust: Konstantin Päts, Arnold Rüütel ja Edgar Savisaar
Kütus kallineb jätkuvalt / Lembit Eespäev

Index Scriptorium Estoniae

Eespäev, Lembit, 1955-

2005-01-01

Kütuste hinnatõusust maailmaturul ning toornafta jätkuvast kallinemisest, mis mõjutab kogu maailmamajandust. Eesti hulgimüüjatele tähendab kütuse kallinemine vajadust täiendava finantseerimise järele. Vt. samas: 13 aastat kütuseäris
Ida-igatsuse põhjapiir / Raivo Paltser

Index Scriptorium Estoniae

Paltser, Raivo

2006-01-01

Hiina traditsiooni järgija R. Paltseri nägemus Lääne inimese ihalusest Vana-Hiina kultuuri järele, kung-fust. Toodud mõningaid näiteid Soome ja Hiina mütoloogiat ühendavast fantaasiafilmist "Igavese armastuse sõdalane - Jade Warrior"
Advokaadi kutse-eetika reason d’etre / Ain Alvin

Index Scriptorium Estoniae

Alvin, Ain, 1959-

2014-01-01

Advokaadi kohustus on kutsetegevuses järgida lisaks seadusele kutse-eetika nõudeid, häid kombeid ja südametunnistust. Mida sellised kohustused sisuliselt tähendavad, millest tuleneb vajadus kutse-eetika kutseühendusesisese reguleerimise järele ja milline on kutse-eetika normide sisu?
Simulating non-isothermal water vapour transfer : an experimental validation on multi-layered building components

NARCIS (Netherlands)

Roels, S.; Depraetere, W.; Carmeliet, J.; Hens, H.

1999-01-01

The aim of this study is to validate different analytical relations used in hygrothermal simulations for the material properties. Therefore, a valida tion experiment on four types of flat roofs has been set up at the laboratory. All rele vant material properties of the individual material layers
Identification and use of an alkane transporter plug-in for application in biocatalysis and whole-cell biosensing of alkanes

DEFF Research Database (Denmark)

Grant, Chris; Deszcz, Dawid; Wei, Yu-Chia

2014-01-01

Effective application of whole-cell devices in synthetic biology and biocatalysis will always require consideration of the uptake of molecules of interest into the cell. Here we demonstrate that the AlkL protein from Pseudomonas putida GPo1 is an alkane import protein capable of industrially rele...
Mis on lääs? / Guy Sorman

Index Scriptorium Estoniae

Sorman, Guy

2008-01-01

Autor on seisukohal, et lääs ei ole geograafiline üksus; ta usub, et lääs on kolmele põhiomadusele tuginev meelelaad, mida naljalt ei kohta nn. idatsivilisatsioonides, need omadused on kirg innovatsiooni järele, võime enesekriitikaks ja sugude võrdsus
AcEST: BP916868 [AcEST

Lifescience Database Archive (English)

Full Text Available . Sequence too short.) sp_hit_id - Definition - Align length - Score (bit) - E-value - Report - TrEMBL (rele...ase 39.9) Link to BlastX Result : TrEMBL (No blast op. Sequence too short.) tr_hit_id - Definition - Align length - Score (bit) - E-value - Report - ...
Suboptimal response to GnRHa long protocol is associated with a common LH polymorphism

DEFF Research Database (Denmark)

Alviggi, C; Clarizia, R; Pettersson, K

2011-01-01

The aim of this observational preliminary trial was to estimate the association between the most common polymorphism of LH (LH-β variant: v-βLH), with different profiles of ovarian response to recombinant human FSH (rhFSH). A total of 60 normogonadotrophic patients undergoing a gonadotrophin-rele...
Kõristid Vene karu tagumikus / Igor Taro

Index Scriptorium Estoniae

Taro, Igor

2008-01-01

Venemaa vajadus Afganistani suunal NATOga koostööd teha ei jää alla alliansi vajadusele Venemaa abi järele, kuna Afganistan kujutab endast narkootikumide eksportijat ja terroriohtu otse Venemaa külje all. Kaart: Afganistan on Venemaale eluliselt sama tähtis kui NATO-le
Valitsus vaeb USA viisavabadusenõudeid / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2008-01-01

USA viisavabaduse aluseks oleva vastastikuse mõistmise memorandumi projekt on täna valitsuse istungi päevakorras. Tšehhi ja USA on juba sõlminud kahepoolse memorandumi, mõnedel hinnangutel on Tšehhi järele andnud kogu ameeriklaste nõudmiste paketile. Lisa: Andmekaitsjad pole viimase seisuga kursis
La mejora del clima laboral: propuesta de herramientas

OpenAIRE

Padial Alcalá, José María

2017-01-01

El clima laboral está relacionado con la RSC cuando tratamos la relación de la organización con el grupo de interés de los empleados. Varios autores han establecido esta conexión encontrando diversas formas de enfocar el clima laboral, siendo rele

Neutrino mass sum-rule

Science.gov (United States)

Damanik, Asan

2018-03-01

Neutrino mass sum-rele is a very important research subject from theoretical side because neutrino oscillation experiment only gave us two squared-mass differences and three mixing angles. We review neutrino mass sum-rule in literature that have been reported by many authors and discuss its phenomenological implications.
Tegn. Red.

African Journals Online (AJOL)

rbr

gawe uit meer as twee maal soveel lemmas sal bestaan. Selfs tien duisend lem- mas sal geensins 'n volledige versameling "etimologiseerbare" Afrikaanse lemmas verteenwoordig nie, en dit is goed dat EWA geensins makrostruktu- rele volledigheid op die agenda het nie. Nogtans, hoewel daar in hierdie stadium niks oor ...
ZKBoo: Faster Zero-Knowledge for Boolean Circuits

DEFF Research Database (Denmark)

Giacomelli, Irene; Madsen, Jesper; Orlandi, Claudio

2016-01-01

variants of IKOS, which highlights their pros and cons for practically rele- vant soundness parameters; ◦ A generalization and simplification of their approach, which leads to faster Σ-protocols (that can be made non-interactive using the Fiat-Shamir heuristic) for state- ments of the form “I know x...
Ontology-based retrieval of bio-medical information based on microarray text corpora

DEFF Research Database (Denmark)

Hansen, Kim Allan; Zambach, Sine; Have, Christian Theil

are exponentially growing, the text corpora are sparse and inconsistent in spite of attempts to standardize the format. Ordinary keyword search may in some cases be insucient to nd rele- vant information and the potential benet of using a semantic approach in this context has only been investigated to a limited...
The Processing and Mechanical Properties of High Temperature/High Performance Composites. Book 5. Processing and Miscellaneous Properties

Science.gov (United States)

1993-04-01

subsurtace crack oriented perpendic:ular In each crack analisis . the enere\\ rele~ise rate (; is deter- to the free surface is solved using standard...deep etching MoSi 2 matrix, (b) cluster of hopper crystals in the same specimen, and (c) closer view of a hopper crystal showing preferential growth
Võidusammas tehakse korda enne valimisi / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2010-01-01

Kaitseministeerium allkirjastas Vabadussõja võidusamba uue valgustuse rajamiseks lepingu ettevõttega KH Energia-Konsult. Valgustus- ja ventilatsioonisüsteem peaks valmima jaanuaris 2011. Tööde järele valvavad Tehnokontrollikeskus OÜ ja Tallinna Tehnikaülikooli spetsialistid. Garantiitööd peab tegema Tšehhi firma Sans Souci
Taassünni ajalooline valu / Toomas Hendrik Ilves

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2006-01-01

Vastukaja Jürgen Habermasi ja Jacques Derrida esseele "Euroopa taassünd pärast sõda". Euroopalikust ühtekuuluvustundest ja vajadusest ühisarusaamade järele Euroopa välis- ja julgeolekupoliitikas. Tuum-Euroopa ideest ja idaaeurooplaste integreerimisest. Ilmunud ka: Eesti Päevaleht : Mõte 16. juuli 2003, lk. 10-13.
Eesti päästetöötajad lendavad appi maavärina ohvritele / Sigrid Laev

Index Scriptorium Estoniae

Laev, Sigrid

2005-01-01

Eesti päästemeeskonna varustusest Lõuna-Aasia maavärinas kannatada saanute abistamiseks. Vt. samas intervjuud päästeameti direktori Mati Raidmaga; Heiki Suurkask. Rüüstamisega hädas Pakistan kisab abi järele; India jätkuv pugemine Euraasia alla põhjustab tugevaid maavärinaid. Kaart: Looduskatastroof
Relativity, Quantum Physics and Philosophy in the Upper Secondary Curriculum: Challenges, Opportunities and Proposed Approaches

Science.gov (United States)

Henriksen, Ellen K.; Bungum, Berit; Angell, Carl; Tellefsen, Catherine W.; Frågåt, Thomas; Bøe, Maria Vetleseter

2014-01-01

In this article, we discuss how quantum physics and relativity can be taught in upper secondary school, in ways that promote conceptual understanding and philosophical reflections. We present the ReleQuant project, in which web-based teaching modules have been developed. The modules address competence aims in the Norwegian national curriculum for…
Moderate activation of IKK2-NF-kB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis.

Science.gov (United States)

Lu, Hong; Lei, Xiaohong; Zhang, Qinghao

2015-07-30

The NF-kB signaling, regulated by IKK1-p52/RelB and IKK2-p65, is activated by various stresses to protect or damage the liver, in context-specific manners. Two previous studies of liver-specific expression of constitutive active IKK2 (IKK2ca) showed that strong activation of IKK2-NF-kB in mouse livers caused inflammation, insulin resistance, and/or fibrosis. The purpose of this study was to understand how moderate activation of IKK2-NF-kB in adult mouse livers alters hepatic gene expression and pathophysiology. We generated mice with adult hepatocyte-specific activation of Ikk2 (Liv-Ikk2ca) using Alb-cre mice and Ikk2ca Rosa26 knockin mice in which a moderate expression of Ikk2ca transgene was driven by the endogenous Rosa26 promoter. Surprisingly, compared to wild-type mice, adult male Liv-Ikk2ca mice had higher hepatic mRNA expression of Ikk2 and classical NF-kB targets (e.g. Lcn2 and A20), as well as IKK1, NIK, and RelB, but no changes in markers of inflammation or fibrosis. Blood levels of IL-6 and MCP-1 remained unchanged, and histology analysis showed a lack of injury or infiltration of inflammatory cells in livers of Liv-Ikk2ca mice. Moreover, Liv-Ikk2ca mice had lower mRNA expression of prooxidative enzymes Cyp2e1 and Cyp4a14, higher expression of antioxidative enzymes Sod2, Gpx1, and Nqo1, without changes in key enzymes for fatty acid oxidation, glucose utilization, or gluconeogenesis. In parallel, Liv-Ikk2ca mice and wild-type mice had similar levels of hepatic reduced glutathione, endogenous reactive oxygen species, and lipid peroxidation. Additionally, Liv-Ikk2ca mice had higher Cyp3a11 without down-regulation of most drug processing genes. Regarding nuclear proteins of NF-kB subunits, Liv-Ikk2ca mice had moderately higher p65 and p50 but much higher RelB. Results of ChIP-qPCR showed that the binding of p50 to multiple NF-kB-target genes was markedly increased in Liv-Ikk2ca mice. Additionally, Liv-Ikk2ca mice had moderate increase in triglycerides in
Variable Persister Gene Interactions with (pppGpp for Persister Formation in Escherichia coli

Directory of Open Access Journals (Sweden)

Shuang Liu

2017-09-01

Full Text Available Persisters comprise a group of phenotypically heterogeneous metabolically quiescent bacteria with multidrug tolerance and contribute to the recalcitrance of chronic infections. Although recent work has shown that toxin-antitoxin (TA system HipAB depends on stringent response effector (pppGppin persister formation, whether other persister pathways are also dependent on stringent response has not been explored. Here we examined the relationship of (pppGpp with 15 common persister genes (dnaK, clpB, rpoS, pspF, tnaA, sucB, ssrA, smpB, recA, umuD, uvrA, hipA, mqsR, relE, dinJ using Escherichia coli as a model. By comparing the persister levels of wild type with their single gene knockout and double knockout mutants with relA, we divided their interactions into five types, namely A “dependent” (dnaK, recA, B “positive reinforcement” (rpoS, pspF, ssrA, recA, C “antagonistic” (clpB, sucB, umuD, uvrA, hipA, mqsR, relE, dinJ, D “epistasis” (clpB, rpoS, tnaA, ssrA, smpB, hipA, and E “irrelevant” (dnaK, clpB, rpoS, tnaA, sucB, smpB, umuD, uvrA, hipA, mqsR, relE, dinJ. We found that the persister gene interactions are intimately dependent on bacterial culture age, cell concentrations (diluted versus undiluted culture, and drug classifications, where the same gene may belong to different groups with varying antibiotics, culture age or cell concentrations. Together, this study represents the first attempt to systematically characterize the intricate relationships among the different mechanisms of persistence and as such provide new insights into the complexity of the persistence phenomenon at the level of persister gene network interactions.
Translation affects YoeB and MazF messenger RNA interferase activities by different mechanisms

DEFF Research Database (Denmark)

Christensen-Dalsgaard, Mikkel; Gerdes, Kenn

2008-01-01

Prokaryotic toxin-antitoxin loci encode mRNA cleaving enzymes that inhibit translation. Two types are known: those that cleave mRNA codons at the ribosomal A site and those that cleave any RNA site specifically. RelE of Escherichia coli cleaves mRNA at the ribosomal A site in vivo and in vitro bu...
Olympicu debüüt võitis esikoha / Tarvo Vaarmets

Index Scriptorium Estoniae

Vaarmets, Tarvo

2006-01-01

Rootsi investeerimisfirma East Capital tunnistas Olympic Casino selle aasta parimaks Ida-Euroopas toimunud börsidebüüdiks. Kommenteerib Peter Elam Hakansson. Vt. samas: Olympicu eelkäija tegi hea tõusu; Peeter Teder. Kõrge tunnustuse pälvisid Gruusia pank ja Vene kinnisvaraarendaja; Reedel võeti Olympicust kasumit. Diagrann: Kiirelt tõusnud aktsia järele andnud
Public sector support to adult job training in Estonia / Kristjan-Olari Leping

Index Scriptorium Estoniae

Leping, Kristjan-Olari, 1980-

2006-01-01

Tehnoloogia kiire areng ja teadmistepõhise ühiskonna tekkimine on avaldanud olulist mõju majanduse olemusele ning muutnud tööjõule esitatavaid nõudeid, oluliselt on suurenenud vajadus elukestva õppe järele. Täiskasvanuhariduse tähtsus, liigid, rahastamine, võimalused täiskasvanute tööalase koolituse meetmete täiustamiseks
Rohelised jõulud / Villem Loigom

Index Scriptorium Estoniae

Loigom, Villem

2007-01-01

Jõuluvana kujundist, mille Haddon Sundblom (1899-1976) lõi Coca-Cola tellimusel. Autori arvates tasub järele mõelda, kuidas jõule mööda saata tagasihoidlike ning vähe looduslikku ressurssi raiskavate sisustuselementidega. Savi, puu, klaas ja õled jõuluehetes. Massimo Giaconi disainitud portselanist kujukesest Christmas Cow Boy. Pipargoogid - parimad jõuluehted
Neeme Jõgi usub Pan-Balti piimanduskontserni rajamisse / Neeme Jõgi ; interv. Viljar Rääsk

Index Scriptorium Estoniae

Jõgi, Neeme

2008-01-01

Läti piimatööstuse Rigas Piensaimnieksi juhatuse esimees Neeme Jõgi vastab küsimustele, mis puudutavad ettevõtte olukorda, ülebaltikumilise piimafirma tulekut, ärikultuuri erinevusi Lätis, sisulise austuse saavutamist, tema põhimõtteid äritegevuses, vajadust skaneerimisoskustega juhi järele ning Parexiga juhtunu mõju lätlastele. Lisa: Neeme Jõgi
Euroopa vajab mootorit, mitte telge / Jeroen Bult

Index Scriptorium Estoniae

Bult, Jeroen

2007-01-01

Euroopa Liidu poliitika arengust kirjutades leiab autor, et igatsus Saksamaa ja Prantsusmaa liidu kui sisuliste juhtide järele on iganenud, sest uusliikmed selliseid juhte ei usaldaks, ning Euroopa tõeliseks mootoriks peaks olema hoopis sügav mure maailma geopoliitiliste trendide, eriti võitluse pärast üha vähenevate energiatagavarade üle
Miks koolis diskrimineeritakse poisse? / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2015-01-01

Eelmisel aastal peetud soolise võrdõiguslikkuse konverentsi sõnumiks on, et Eesti koolis diskrimineerivad õpetajad poisse. Küsimusele, kuidas poisid tüdrukutele järele aidata, vastavad Tallinna prantsuse lütseumi õpetaja Anneli Oidsalu, TLÜ kasvatusteaduste õppejõud Tiiu Kuurme, psühholoog Tiia Lister, haridustöötaja Enn Veesalu ja õpetaja Lembit Jakobson
Anti-HIV drugs, lopinavir/ritonavir and atazanavir, modulate innate immune response triggered by Leishmania in macrophages: the role of NF-κB and PPAR-γ.

Science.gov (United States)

Alves, Érica Alessandra Rocha; de Miranda, Marthina Gomes; Borges, Tatiana Karla; Magalhães, Kelly Grace; Muniz-Junqueira, Maria Imaculada

2015-02-01

This study evaluated the influence of HIV protease inhibitors lopinavir/ritonavir (LPV/RTV) and atazanavir (ATV) on macrophage functions during their first interaction with Leishmania. Macrophages from BALB/c mice treated for 10days with LPV/RTV and ATV, infected or not in vitro with L. (L.) amazonensis, were used to investigate the effects of these drugs on infection index, leishmanicidal capacity, cytokine production and PPAR-γ and RelB expression. LPV/RTV and ATV treatments significantly increased the infection index and the percentage of Leishmania-infected macrophages compared to untreated infected macrophages. There was no correlated increase in the production of NO and H2O2 leishmanicidal molecules. Promastigotes derived from Leishmania-infected macrophages from LPV/RTV and ATV-treated BALB/c mice had an in vitro growth 45.1% and 56.4% higher in groups treated with LPV/RTV and ATV than with PBS in culture. ATV treatment reduced IL-12p70 and IL-10 secretion in Leishmania-infected macrophages, but had no effect on IL-23 and TNF production. LPV reduced IL-10 and had no effect on IL-12p70, TNF and IL-23 secretion. ATV treatment decreased PPAR-γ expression in Leishmania-infected macrophages compared to untreated infected macrophages. In addition, LPV/RTV, but not ATV, reduced RelB cytoplasm-to-nucleus translocation in Leishmania-infected macrophages. Results showed that LPV/RTV and ATV HIV protease inhibitors were able to modulate innate defense mechanisms against Leishmania via different intracellular pathways. Although HIV protease inhibitors are highly efficient to control the Human Immunodeficiency Virus, these drugs might also influence the course of leishmaniasis in HIV-Leishmania-co-infected individuals. Copyright © 2014 Elsevier B.V. All rights reserved.
Studi Pengaruh Pemasangan NGR 40 Ohm pada Uprating Transformator 2 GI Gianyar Terhadap Gangguan Hubung Singkat 1 Phasa Tanah

Directory of Open Access Journals (Sweden)

Arya Surya Darma

2017-08-01

Full Text Available Along with the development of ever-increasing burden on the GI Gianyar then the transformer unit 2 with a capacity of 30 MVA will be uprating with a capacity of 60 MVA transformer. To maintain the continuity and reliability of the flow of electrical power to the consumer , NGR (Neutral Grounding Resistance and relay SBEF is used as the safety equipment of the short circuit 1 phase to ground was not in to the neutral point of the transformer. Uprating of transformers that have been done changes on 1 phase fault current to ground when using a direct earthing systems with a value to become 1838.21 A. While the value of the short-circuit current 1 phase to ground after pairing NGR 40 Ohm value is fixed at 288.675 A, so that the current setting and time relay SBEF fixed at 90 A and 7.067 seconds. The analysis result from the effect of installation NGR and rele SBEF on the transformer 60 MVA against short circuit 1 phase to ground has the ability good protection for the value of the fault current is able to be reduced from 1838,21 A into 288.675 A after pairing NGR 40 Ohm and time is needed SBEF to handle distractions 7.067 seconds. Intisari- Seiring dengan perkembangan beban yang terus meningkat di GI Gianyar maka transformator unit 2 berkapasitas 30 MVA akan di lakukan uprating (penggantian dengan transformator berkapasitas 60 MVA. Untuk menjaga kontinyuitas dan keandalan aliran daya listrik sampai ke konsumen (beban, NGR (Neutral Grounding Resistance dan rele SBEF dipergunakan sebagai peralatan pengaman dari gangguan hubung singkat phasa tanah agar arus gangguan 1 phasa ke tanah tidak sampai mengalir ke titik netral transformator. Dari uprating transformator yang sudah di lakukan terjadi perubahan pada arus gangguan 1 phasa ke tanah jika menggunakan sistem pentanahan langsung (solid grounding menjadi 1838,21 A. Sedangkan nilai dari arus hubung singkat 1 phasa ke tanah setelah dipasangkan NGR 40 Ohm nilainya tetap sebesar 288,675 A

Esseid / John Gray ; tõlk. Ann Must

Index Scriptorium Estoniae

Gray, John

2007-01-01

"Biotehnoloogia ja posthumaanne tulevik" Uute tehnoloogiatega kaasnevatest ohtudest. "Vaatemängude ühiskonnas tagasi" Staarikultuse ja meelelahutustööstuse mõjust poliitikale ja majandusele. "Uued ressursisõjad" Ideoloogiliste konfliktide asendumisest geopoliitilistega. "Ameerika sõda kurjuse vastu" Ameerika välispoliitika teeb ohtlikuks usk kurja kaotamise võimalikkusse. "Aruanne akadeemiale" Inimkonna laastavast mõjust keskkonnale, vajadusest rahvastikukontrolli järele
Boekbesprekings : Book Reviews

African Journals Online (AJOL)

1974-05-18

May 18, 1974 ... It is consequently a we come addItl(;lTI to the orthopaedic library. The ~rst sectIOn of.the book gives a very concise and lucid. synopsIS of.the pertInent mechanical facts. and the second part deals WIth the rele,:,ant biological aspects of the musculo- skeletal system..The t?ird and final section provides a brief.
Õpetajate-õpilaste interaktsioon ja sisuloome suhtlusportaalides: õpetajate arvamused ja kogemused

Directory of Open Access Journals (Sweden)

Sandra Räim

2014-11-01

Full Text Available Artikli eesmärk on anda ülevaade õpetajate arvamustest ja kogemustest, mis puudutavad õpetajate ja õpilaste interaktsiooni ja sisuloomet suhtlusportaalides. Fookusgrupi intervjuudes nelja kooli keskkooliõpetajatega (N = 21 uuriti, milliseid erinevusi on õpetajad täheldanud enda ja õpilaste loodud veebisisus ning millistel juhtudel ja mil viisil on õpetajad pidanud vajalikuks õpilaste suhtlusportaalide postitustele reageerida. Muu hulgas sooviti teada, millistele alustele tugineb õpetaja-õpilase suhtlusportaali sõprus ning kas õpetajad tunnevad vajadust sotsiaalmeedia suhtlust suunavate käitumisjuhiste järele. Intervjuude kvalitatiivsest sisuanalüüsist nähtub, et õpetajate arvates jagavad õpilased suhtlusportaalides liigselt privaatset infot, mistõttu pidasid nad enda kohuseks ebasobivaid postitusi märgates õpilaste sisuloomesse sekkuda. Õpetajad võtsid ka suhtlusportaalides endale õpilaste harija ja mentori rolli ning soovisid oma veebikäitumisega pakkuda eeskuju, samas ei adunud nad täiel määral õpetaja-õpilase veebisuhtluse võimalikke tagajärgi. Õpetaja-õpilase veebisuhtlust reguleerivate käitumisjuhiste järele aga vajadust ei nähtud. Uuringu tulemused viitavad veebisisu loomega kaasnevatele põlvkondlikele erinevustele ning avavad õpetajate-õpilaste probleeme suhtlusportaali auditooriumi tajumisel. Summary
Iraani president: USA võim aitas kaasa terrorirünnakute korraldamisele / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2010-01-01

ÜRO peaassambleel kõne pidanud Iraani presidendi Mahmoud Ahmadinejadi hinnangul on kapitalism kokku varisemas ja on tekkinud vajadus uue maailma juhtimise süsteemi järele. Mahmoud Ahmadinejad leidis, et ameeriklased võisid ära kasutada üht terrorirühmitust ja aidata sellel rünnakuid korraldada. USA, EL-i riikide, Austraalia, Uus-Meremaa, Kanada ja Costa Rica delegatsioonid lahkusid saalist
Naftasõltlane haugub valede asjade peale / Gwynne Dyer

Index Scriptorium Estoniae

Dyer, Gwynne

2006-01-01

Ilmunud ka: Molodjozh Estonii 13. veebr. lk. 12. Autor kritiseerib USA president George Bushi kütusepoliitikat, kus ta soovib vähendada riigi naftaimporti Lähis-Idast 75% võrra ning maaõli asendada kääritatud taimsetest jäätmetest aetud etanooliga, samas sõnagi lausumata kütuse kokkuhoiu vajalikkuse kohta, vähendamaks nõudlust nafta järele
Vaene ja rikas ostavad kaltsukas kõrvuti / Sirje Niitra

Index Scriptorium Estoniae

Niitra, Sirje, 1948-

2007-01-01

Nõudlus second hand kaupade järele on Eestis tõusnud: kui 2005. aastal müüdi second hand kaupu kokku 814 mln ja 2006. aastal 853 mln krooni eest, siis selle aasta esimese kuue kuu müügimaht on juba 403 miljonit krooni. Eesti second hand turgu valitseb Humana, kes omab sorteerimiskeskust ja 13 kauplust. Vt. samas: Näitlejanna: See on nii õige asi
Poemas: Uno Llega/ Lucy Cristina

OpenAIRE

Testa Garibaldo, Martín

2009-01-01

con sus hojas sueltas a la comparación un par de ideas testimonios denuncias amores todo el universal país que te ha costado alinearlo en papel uno llega con hojas sueltas su voz su mística en la mano con la que toca varias veces hasta que le abren entra toma asiento a la primera señal se levanta lee relee
Öise õppimise saladus / Marii Karell

Index Scriptorium Estoniae

Karell, Marii

2001-01-01

Üliõpilaslehe 25 küsitletud tudengist tarvitavad või on tarvitanud eksamiteks valmistudes: 3 amfetamiini, 1 efedriini sisaldavat nohurohtu, 1 sõbrannale retseptiga kirjutatud tablette, 3 kofeiinitablette; 11 joob ohjeldamatult kohvi, 7 kallab kurgust alla teed, 4 haarab ajapuudusel energiajoogi järele, 4 ahmib valimatult vitamiine, 1 joob vahel Coca-Colat ja 2 sööb magusaisu rahuldamiseks šokolaadi
Kõik ei ole action / Mari Sobolev

Index Scriptorium Estoniae

Sobolev, Mari, 1968-

1998-01-01

Noorte videoprojektidest. Marko Laimre ja Andrus Kõresaare "Egoistically Correct", ainus actionil rajanev video. Jasper Zoova "Sheeps Are Everywhere". J. Zoova ja Tarrvi Laamannni "Fuck". Karol Kallase kureeritud näitusel "Kunstnik tapab koletise" "Kullo" galeriis olnud Jan Bergi, Meelis Salujärve, Al Paldroki videod, Andrus Joonase töö põhjal tehtud Kiwa video "Kunstnik tapab koletise". Publiku soov vaatemängu järele.
Everyday life in UK Probation Approved Premises for sex offenders

OpenAIRE

Reeves, Carla

2016-01-01

This international edited volume of cutting-edge critical prison research explores key themes of deprivations, stigma, power, culture and vulnerability in a breadth of penal settings and prisoner populations. Ranging across North America and Canada, Western, Central and Eastern Europe, Australia, this research considers: young offenders and juvenile institutions; sex offenders; therapeutic environments; wrongfully convicted prisoners; female prisons and prisoners; parents in prison; post-rele...
RelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure?

Science.gov (United States)

Masat, Elisa; Gasparini, Chiara; Agostinis, Chiara; Bossi, Fleur; Radillo, Oriano; De Seta, Francesco; Tamassia, Nicola; Cassatella, Marco A; Bulla, Roberta

2015-10-14

It is known that excessive inflammation at fetal-maternal interface is a key contributor in a compromised pregnancy. Female genital tract is constantly in contact with microorganisms and several strategies must be adopted to avoid pregnancy failure. Decidual endothelial cells (DECs) lining decidual microvascular vessels are the first cells that interact with pro-inflammatory stimuli released into the environment by microorganisms derived from gestational tissues or systemic circulation. Here, we show that DECs are hypo-responsive to LPS stimulation in terms of IL-6, CXCL8 and CCL2 production. Our results demonstrate that DECs express low levels of TLR4 and are characterized by a strong constitutive activation of the non-canonical NF-κB pathway and a low responsiveness of the canonical pathway to LPS. In conclusion, DECs show a unique hypo-responsive phenotype to the pro-inflammatory stimulus LPS in order to control the inflammatory response at feto-maternal interface.
Sledování markerů oxidačního stresu u modelu chronického zánětu tlustého střeva

OpenAIRE

Hocková, Erika

2010-01-01

Crohn's disease and ulcerative colitis are both entities of inflammatory bowel disease (IBD). The nuclear transcription factor kappaB (NFκB) family consists of five different members, which are namely p65 (RelA), c-Rel, RelB, p50 and p52. NFκB has ability to promote the expression of various proinflammatory genes, to influence the course of mucosal inflammation and to mediate different cell-type specific effects. Bilirubin is an endogenous substance with anti-oxidative and anti-inflammatory e...
Kus vanaduspäevi veeta? / Christopher Farrell

Index Scriptorium Estoniae

Farrell, Christopher

2008-01-01

Paljude kodud - inimeste väärtuslikem vara ja pensioniplaanide alustala - ei paku tänapäeval enam kuigi suurt hubasust. Rahvastiku vananedes suureneb nõudlus väiksemate kodude järele ning paljud suuremad tulevad turule. Soovi korral oma koju jääda kasutavad pensionärid tagurpidi hüpoteeklaenu, mis annab võimaluse võtta oma kodu tagatisel laenu. Lisa: Tagurpidi hüpoteeklaen
Riskikapital vajab riigi kehtestatud mängureegleid / Peeter Saks

Index Scriptorium Estoniae

Saks, Peeter

2004-01-01

AS-i Suprema Securities juhatuse esimehe sõnul on Euroopa riskikapitali turul selge nõudlus sobiva seadusliku raamistiku ja hea mainega riigi või piirkonna järele, Eestil on praegu võimalus kujuneda Euroopa üheks riskikapitali keskuseks. Autori arvates peaks esimeseks sammuks olema eraldi riskikapitali seaduse loomine. Vt. samas: Andrus Ansip, Taavi Veskimägi ja Linnar Viik vastavad küsimusele, kas Eesti vajab riiklikku riskikapitali fondi
Motivate to Learn: other ways of learning Biology, Maths and other Sciences

OpenAIRE

Almeida, M. J.; Nobre, Alexandra; Pinto, Augusta; Cunha, Lília; Maciel, Elsa Marina Costa; Almeida Aguiar, Cristina; Forjaz, Maria Antónia

2014-01-01

The development of teaching and learning strategies that effectively assist in the understanding of scientific knowledge is an ongoing challenge. Doing experiments outside the classroom, one of the recommended approaches, presents some risks, because students can divert their attention from the pedagogical objective of activity [1]. However, experts agree in considering that learning outside the classroom can be used to facilitate Education. Providing students with learning activities in rele...
President Ilves : Let's Make Estonia Greater! = President Ilves : Teeme Eesti suuremaks!

Index Scriptorium Estoniae

2006-01-01

Euroopa Parlamendi aseesimees Toomas Hendrik Ilves valiti Eesti uueks presidendiks 2006. aasta 23. septembril. Lisa: Toomas Hendrik Ilves (eluloolised andmed, haridus, karjäär). Vt. samas: Toomas Hendrik Ilves: More Cooperation, More Europe = Toomas Hendrik Ilves: Rohkem koostööd, rohkem Euroopat. T.H. Ilves räägib oma sõnumist Euroopale, vajadusest Euroopa Liidu ühise energia- ja julgeolekupoliitika järele, Eesti suhetest Venemaa ja USAga
Riigita rahvad karjuvad oma õiguste järele / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2005-01-01

IX PÖFFi filme - "Kohe paradiisi" ("Paradise Now") : režissöör Hany Abu-Assad : Holland - Saksamaa - Prantsusmaa - Palestiina 2005, "Kilpkonnad suudavad lennata" : režissöör Bahman Ghobadi : Iraan - Iraak 2004
TRATAMENTUL APLICAT PRIZONIERILOR ROMÂNI DIN LAGĂRELE (ALIATE SOVIETICE

Directory of Open Access Journals (Sweden)

Gheorghe Stefan

2006-05-01

Full Text Available Romanian’s participation in the second world war will bring in the attention of Romanian authorities a new issue, concerning the resolution for the status of Romanian prisoners fallen on the East front and not only. During the entire military conflagration numerous soldiers of the Soviet forces before stopping the hostilities and after. As soon as Romania has joined the U.N., the coalition in the war against Hitler, Romanian Army will register a significant number of prisoners, captured by Wermacht, a great part of them coming in the possession of the Russians.
Assessment of junior doctors? admission notes: do they follow what they learn?

OpenAIRE

Barnawi, Rashid A.; Ghurab, Abdulaziz M.; Balubaid, Hassan K.; Alfaer, Sultan S.; Hanbazazah, Kamal A.; Bukhari, Mohammed F.; Hamed, Omayma A.; Bakhsh, Talal M.

2017-01-01

Objectives To assess the completeness of history-taking and physical-examination notes of junior doctors at King Abdulaziz University Hospital per the approach they learned in medical school. Methods In this retrospective study, we reviewed 860 admission notes written by 269 junior doctors (interns and residents) in an academic tertiary-care medical centre in Jeddah, Saudi Arabia, over a two-month period. Notes were evaluated for completeness using a checklist developed with reference to rele...
Sertifikaat on üha kasulikum / Kristel Arukask

Index Scriptorium Estoniae

Arukask, Kristel

2015-01-01

Veel viis aastat tagasi ei olnud Eestis PEFC sertifitseeritud puidu järele nõudlust, kui tänaseks on olukord muutunud. Eestis on PEFC metsamajanduse sertifikaadi omanikke kaks, Eesti Erametsaliit ja RMK. Erametsaliidul on alates 2010. a PEFC metsamajandamise rühmasertifikaat, mis tähendab seda, et rühma liikmeteks saavad olla kõik erametsaomanikud, kes selleks soovi avaldavad ja on nõus PEFC standardi nõudeid täitma

Teaching Workplace Skills to Technical Communicators

OpenAIRE

Darina M. Slattery; Yvonne Cleary

2013-01-01

peer-reviewed In this article, we introduce two programmes in technical communication (one distance, and one on-campus) offered by the University of Limerick. Both programmes have been running for several years, but are regularly reviewed to ensure that they remain relevant. We describe how these programmes correspond to industry needs, and how they develop core competencies of technical communicators. We outline two key types of assignment (writing and development), and explain their rele...
Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment.

OpenAIRE

Yamauchi, K; Tomita, M; Giehl, T J; Ellison, R T

1993-01-01

Although the antimicrobial activity of lactoferrin has been well described, its mechanism of action has been poorly characterized. Recent work has indicated that in addition to binding iron, human lactoferrin damages the outer membrane of gram-negative bacteria. In this study, we determined whether bovine lactoferrin and a pepsin-derived bovine lactoferrin peptide (lactoferricin) fragment have similar activities. We found that both 20 microM bovine lactoferrin and 20 microM lactoferricin rele...
On the Fractional Mean Value

OpenAIRE

Hosseinabadi, Abdolali Neamaty; Nategh, Mehdi

2014-01-01

This work, dealt with the classical mean value theorem and took advantage of it in the fractional calculus. The concept of a fractional critical point is introduced. Some sufficient conditions for the existence of a critical point is studied and an illustrative example rele- vant to the concept of the time dilation effect is given. The present paper also includes, some connections between convexity (and monotonicity) with fractional derivative in the Riemann-Liouville sense.
NIK is involved in constitutive activation of the alternative NF-κB pathway and proliferation of pancreatic cancer cells

International Nuclear Information System (INIS)

Nishina, Takashi; Yamaguchi, Noritaka; Gohda, Jin; Semba, Kentaro; Inoue, Jun-ichiro

2009-01-01

Pancreatic cancer has one of the poorest prognoses among human neoplasms. Constitutive activation of NF-κB is frequently observed in pancreatic cancer cells and is involved in their malignancy. However, little is known about the molecular mechanism of this constitutive NF-κB activation. Here, we show that the alternative pathway is constitutively activated and NF-κB-inducing kinase (NIK), a mediator of the alternative pathway, is significantly expressed in pancreatic cancer cells. siRNA-mediated silencing of NIK expression followed by subcellular fractionation revealed that NIK is constitutively involved in the processing of p100 and nuclear transport of p52 and RelB in pancreatic cancer cells. In addition, NIK silencing significantly suppressed proliferation of pancreatic cancer cells. These results clearly indicate that NIK is involved in the constitutive activation of the alternative pathway and controls cell proliferation in pancreatic cancer cells. Therefore, NIK might be a novel target for the treatment of pancreatic cancer.
NIK is involved in constitutive activation of the alternative NF-{kappa}B pathway and proliferation of pancreatic cancer cells

Energy Technology Data Exchange (ETDEWEB)

Nishina, Takashi [Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Yamaguchi, Noritaka [Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041 (Japan); Gohda, Jin [Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Semba, Kentaro [Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041 (Japan); Department of Life Science and Medical Bio-science, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480 (Japan); Inoue, Jun-ichiro, E-mail: jun-i@ims.u-tokyo.ac.jp [Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan)

2009-10-09

Pancreatic cancer has one of the poorest prognoses among human neoplasms. Constitutive activation of NF-{kappa}B is frequently observed in pancreatic cancer cells and is involved in their malignancy. However, little is known about the molecular mechanism of this constitutive NF-{kappa}B activation. Here, we show that the alternative pathway is constitutively activated and NF-{kappa}B-inducing kinase (NIK), a mediator of the alternative pathway, is significantly expressed in pancreatic cancer cells. siRNA-mediated silencing of NIK expression followed by subcellular fractionation revealed that NIK is constitutively involved in the processing of p100 and nuclear transport of p52 and RelB in pancreatic cancer cells. In addition, NIK silencing significantly suppressed proliferation of pancreatic cancer cells. These results clearly indicate that NIK is involved in the constitutive activation of the alternative pathway and controls cell proliferation in pancreatic cancer cells. Therefore, NIK might be a novel target for the treatment of pancreatic cancer.
Efficacy and safety of transcatheter aortic valve replacement in aortic stenosis patients at low to moderate surgical risk: a comprehensive meta-analysis

OpenAIRE

Elmaraezy, Ahmed; Ismail, Ammar; Abushouk, Abdelrahman Ibrahim; Eltoomy, Moutaz; Saad, Soha; Negida, Ahmed; Abdelaty, Osama Mahmoud; Abdallah, Ahmed Ramadan; Aboelfotoh, Ahmed Magdy; Hassan, Hossam Mahmoud; Elmaraezy, Aya Gamal; Morsi, Mahmoud; Althaher, Farah; Althaher, Moath; AlSafadi, Ammar M.

2017-01-01

Background Recently, transcatheter aortic valve replacement (TAVR) has become the procedure of choice in high surgical risk patients with aortic stenosis (AS). However, its value is still debated in operable AS cases. We performed this meta-analysis to compare the safety and efficacy of TAVR to surgical aortic valve replacement (SAVR) in low-to-moderate surgical risk patients with AS. Methods A systematic search of five authentic databases retrieved 11 eligible studies (20,056 patients). Rele...
Costing and performance in healthcare management

OpenAIRE

Tarricone, Rosanna; Torbica, Aleksandra

2012-01-01

This chapter describes and discusses the methods for cost analysis of healthcare services in order to assess and compare the economic value of health outputs at the level of healthcare organizations. The economic principles underpinning the assessment of the value of healthcare services – opportunity costs and shadow prices – are presented together with the management accounting approach to cost services. The key features of micro-costing and gross-costing are also discussed and their rele...
Unge og Sorg i trykte medier

OpenAIRE

Andersen, Helle Maria; Jønsson, Naja; Sund, Christina Brøns; Vastring, Helle; Wetterstein, Emilie Wolff

2008-01-01

In this project we investigate the ways in which the organisation, Unge og Sorg, can be pro-moted in print media. We take a starting point in an empirical study of the target audience by focussing on these audiences’ life situations, need of information, and perceptions of rele-vance, expense and value of information. The methodological basis of this project consists of social constructivism, qualitative focus groups, and creative methods. The theoretical foundation comprises a communication ...
Evaluation of a Tailored Direct-Mail Marketing Strategy for Recruiting the 19- to 23-Year-Old Market.

Science.gov (United States)

1983-05-01

17AD-A12.9 860 EVALUATION OF A TAILORED DIRECT-MAIL MARKETING STRATEGY 1/ FOR RECRUITNG TH.U) WESAT INC ROCKVILLE MD K FERNANDES ET AL MAY 83 NPRDC...STANDARDS-1963-A EVALUATION OF A TAILORED DIRECT-MAIL MARKETING STRATEGY FOR RECRUITING THE 19- TO 23-YEAR-OLD MARKET APPRVEDFORPUBLIC RELE AnE [B...EVALUATION OF A TAILORED DIRECT-MAIL MARKETING STRATEGY FOR RECRUITING THE 19- TO 23-YEAR-OLD MARKET Kathleen Fernandes Navy Personnel Research and
Detailed RIF decomposition with selection : the gender pay gap in Italy

OpenAIRE

Töpfer, Marina

2017-01-01

In this paper, we estimate the gender pay gap along the wage distribution using a detailed decomposition approach based on unconditional quantile regressions. Non-randomness of the sample leads to biased and inconsistent estimates of the wage equation as well as of the components of the wage gap. Therefore, the method is extended to account for sample selection problems. The decomposition is conducted by using Italian microdata. Accounting for labor market selection may be particularly rele...
Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

OpenAIRE

Eisen, Andrew; Lemon, Roger; Kiernan, Matthew C.; Hornberger, Michael; Turner, Martin R.

2015-01-01

There is growing evidence that mirror neurons, initially discovered over two decades ago in the monkey, are present in the human brain. In the monkey, mirror neurons characteristically fire not only when it is performing an action, such as grasping an object, but also when observing a similar action performed by another agent (human or monkey). In this review we discuss the origin, cortical distribution and possible functions of mirror neurons as a background to exploring their potential rele...
Jorge Isaacs en su tiempo...

Directory of Open Access Journals (Sweden)

Arturo Laguado

1983-06-01

Full Text Available 1867 marca una fecha de importancia para la literatura sudamericana; en este año Jorge Isaacs publica la "María". Poco queda por agregar sobre esta novela, leída y releída por varias generaciones, incansablemente analizada por los críticos más autorizados de la literatura universal, pero existen ciertos aspectos anecdóticos, que pueden ayudarnos a conocer mejor las circunstancias que rodearon el nacimiento de la obra.
The determinants of loan contracts to business firms

OpenAIRE

Pham, Thi Thu Trà; Lensink, Robert

2006-01-01

This paper deals with loan contracting from a private bank in Vietnam. We focus on the main loan contract features that the bank uses in lending to business firms, namely loan maturity, collateral and loan interest rate. Based upon the simultaneous equation model of Dennis et al. (2000) and the bank’s loan contracting policies, we examine the possible interdependency of the three different loan contract terms. Also, we try to determine which firm characteristics and exogenous factors are rele...
Appendiceal diverticulum associated with chronic appendicitis

OpenAIRE

Zubieta-O’Farrill, Gregorio; Guerra-Mora, José Raúl; Gudiño-Chávez, Andrés; Gonzalez-Alvarado, Carlos; Cornejo-López, Gilberto Bernabe; Villanueva-Sáenz, Eduardo

2014-01-01

INTRODUCTION: Appendiceal diverticulosis is a rare entity, with a global incidence between 0.004% and 2.1% of all appendectomies. It has been related with an elevated risk of perforation in comparison to acute appendicitis, as well as an increased risk for synchronic appendicular cancer in 48% of the cases, and colonic cancer in 43%. The incidence of chronic appendicitis has been reported in 1.5% of all appendicitis cases. PRESENTATION OF CASE: We present a 73-year-old female, with no rele...
Filmid, mis küsivad vastutuse järele / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2006-01-01

Mängufilm "Laps" ("L'Enfant") : autorid Jean-Pierre ja Luc Dardenne : Belgia - Prantsusmaa 2005 ja "Ustav aednik" ("The Constant Gardener") : režissöör Fernando Meirelles John le Carre raamatu järgi : Suurbritannia - Saksamaa 2005. Filme ühendavast teemast - vastutusest - ja selle võtmise paratamtusest
Ema, kes hõikab poja järele / Kätlin Kaldmaa

Index Scriptorium Estoniae

Kaldmaa, Kätlin, 1970-

2007-01-01

Arvustus: Jordan, Neil. Vari / tõlkinud Krista Kaer. Tallinn : Varrak, 2006 ; McCall Smith, Alexander. Unenägude Angus : keldi unenägude jumal / inglise keelest tõlkinud Kätlin Kaldmaa. [Tallinn] : Eesti Päevaleht, 2007
A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions

Directory of Open Access Journals (Sweden)

Alexander Visekruna

2012-01-01

Full Text Available The transcription factors of the Rel/NF-κB family function as key regulators of innate and adoptive immunity. Tightly and temporally controlled activation of NF-κB-signalling pathways ensures prevention of harmful immune cell dysregulation, whereas a loss of control leads to pathological conditions such as severe inflammation, autoimmune disease, and inflammation-associated oncogenesis. Five family members have been identified in mammals: RelA (p65, c-Rel, RelB, and the precursor proteins NF-κB1 (p105 and NF-κB2 (p100, that are processed into p50 and p52, respectively. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T-cell lymphocytes, certain genes essential for immune function such as Il2 and Foxp3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T-cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells (APCs controls a delicate balance between tolerance and immunity. This review gives a selective overview on recent progress in understanding of diverse roles of c-Rel in regulating adaptive immunity.
Military Review: NATO, US Army Europe

Science.gov (United States)

1991-07-01

to march to the soiurK~qt sions" to move disperseid, concenrait to fight. battle, falling on the enemy’s identfied & ian & These theoies provided the...brigade, "Now, Maitland , finesse and tacic Wnen A=Y now’s your time," signaled the final defeat ofNa- agai and again throughout hk poleon’s Imperial Guard...black market. The results were the 1987 to This latest publication of SIPRI is timely, rele- 1988 Scud B attacks between Ian and Iraq. Ironi- vant and
Dokumente küüditajatelt

Index Scriptorium Estoniae

2008-01-01

Ajakirjas on avaldatud küüditajate raportid 1941. aasta küüditamisel valitsenud meeleolude kohta: "[EK(b)P Valgamaa Komitee] aruanne EK(b)P KK sekretär sms. Särele" (16. juuni 1941.a) ; "Väljavõte EK(b)P Valgamaa Komitee informatsioonist EK(b)P Keskomiteele ajavahemikust 8.-14. juunini 1941. a." (17. juuni 1941. a) ; "Väljavõte EK(b)P Tartumaa Komitee nädalainformatsioonist EK(b)P Keskkomiteele 9.-16. juunini 1941. a." (17. juuni 1941. a.)
Strategii de PR în retorica electorala din Parlamentarele -2014, Republica Moldova vs „revoluția crizantemelor”, octombrie 2015 (PR strategies in the electoral rhetoric during the parliamentary elections in 2014, Republic of Moldova vs „the chrysanthemums revolution”, october 2015)

OpenAIRE

Aurelia PERU-BALAN

2015-01-01

In this article the author approaches the trends of the electoral rhetoric during the parliamentary elections that were held on 30th of November. The article determines which are the most used campaign issues with a mobilizing effect on the voters; among these – the external path of the Republic of Moldova. During the last five years, the right and center-right wing parties have chosen the EU integration, the left-wing parties – the Eurasian Union. The contribution also analyzes the most rele...

Wireless Home Automation System using IoT

Directory of Open Access Journals (Sweden)

Alexandra MIHALACHE

2017-01-01

Full Text Available Nowadays, the chance of having an automated home is no longer a fancy luxury, but a reality accessible to a wide range of consumers, because smart home systems have replaced those that only automated the home in the past. More and more solutions based on IoT are being devel-oped to transform homes into smart ones, but the problem is that the benefits of home automa-tion are still not clear to everyone as they are not promoted enough, so we cannot talk about a broad mass of consumers already using integrated or DIY solutions to improve their lives. In this paper, I will present a home automation system using Arduino Uno integrated with rele-vant modules which are used to allow remote control of lights or fans, changes being made on the basis of different sensors data. The system is designed to be low cost and expandable, bring-ing accessibility, convenience and energy efficiency.
Agendid, nuhid, pealekaebajad / Tiit Noormets

Index Scriptorium Estoniae

Noormets, Tiit, 1959-

2012-01-01

Siiani ei ole peaaegu üldse avaldatud Nõukogude julgeoleku tööriistade - agentide töö peamist "nähtavat" jälge - nende ettekandeid. Agent "Välk" ehk kodanikunimega Adolf Lõhmus oli üks tippagente, tänu kellele lõpuks langes vendade Saalistete metsavennasalk. Lisaks agentidele sai julgeolek andmeid omaalgatuslikelt pealekaebajatelt. Võrumaa komsomolitegelase Hans Valli töö näitab sihikindlat ja põhjalikku tööd inimeste järele nuhkimises. Lisatud agendi "Välk" ja Hans Valli töö näited
Errata to "Mansouri-Sexl Test Theory: The Question of Equivalence between Special Relativity and Ether Theories" (Letters to Progress in Physics

Directory of Open Access Journals (Sweden)

Rybicki M.

2016-07-01

Full Text Available The title paper [1] contains an essential mistake committed by the present author. Namely, the Mansouri and Sexl generalized transformation of time, as well as the rele- vant form of the Lorentz transformation of time have been erroneously read and typed. In consequence, a certain part of the paper (indicated in the table, below requires re- placing to conform to the correct equations. The rest of the paper, except for the minor corrections indicated in the Errata, still remains valid. Let me apologize to the Readers and Editors for the inconvenience.
REFLEXIONES SOBRE EL CONVENIO ARBITRAL EN EL DERECHO PERUANO

OpenAIRE

Matheus López, Carlos Alberto; Pontificia Universidad Católica del Perú

2004-01-01

El presente trabajo se inicia con la observación de la particular rele- vancia que tiene el convenio arbitral para el derecho de arbitraje, junto con la afirmación del carácter negocial de éste. Seguidamente, se analiza el tema de la libertad formal del convenio y los diversos tipos de formalización de este: por referencia, unidocumental y pluridocumental. Luego, se aborda el tema de la capacidad para la suscripción del convenio, principalmente fijada en aquélla de goce y de ejercicio, para a...
Nuclear Factor κB is required for tumor growth inhibition mediated by enavatuzumab (PDL192, a humanized monoclonal antibody to TweakR

Directory of Open Access Journals (Sweden)

James W. Purcell

2014-01-01

Full Text Available TweakR is a TNF receptor family member, whose natural ligand is the multifunctional cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in certain cancer cell lines and the overexpression of TweakR in many solid tumor types led to the development of enavatuzumab (PDL192, a humanized IgG1 monoclonal antibody to TweakR. The purpose of this study was to determine the mechanism of action of enavatuzumab’s tumor growth inhibition and to provide insight into the biology behind TweakR as a cancer therapeutic target. A panel of 105 cancer lines was treated with enavatuzumab in vitro; and 29 cell lines of varying solid tumor backgrounds had >25% growth inhibition in response to the antibody. Treatment of sensitive cell lines with enavatuzumab resulted in the in vitro and in vivo (xenograft activation of both classical (p50, p65 and non-classical (p52, RelB NFκB pathways. Using NFκB DNA binding functional ELISAs and microarray analysis, we observed increased activation of NFκB subunits and NFκB regulated genes in sensitive cells over that observed in resistant cell lines. Inhibiting NFκB subunits (p50, p65, RelB, p52 and upstream kinases (IKK1, IKK2 with siRNA and chemical inhibitors consistently blocked enavatuzumab’s activity. Furthermore, enavatuzumab treatment resulted in NFκB-dependent reduction in cell-division as seen by the activation of the cell cycle inhibitor p21 both in vitro and in vivo. The finding that NFκB drives the growth inhibitory activity of enavatuzumab suggests that targeting TweakR with enavatuzumab may represent a novel cancer treatment strategy.
Tahad töötajaid, mine koju järele / Merike Pitk

Index Scriptorium Estoniae

Pitk, Merike, 1959-

2007-01-01

Tööturuameti andmetel ei leidu nii palju töötajaid, et tööandjate vajadusi rahuldada. Tööotsijale ei sobi sageli töökohad madala palga, halva bussiühenduse või pikaajalise töötuse tõttu. Vt. samas: Kvartali jooksul Tööturuametis registreeritud tööpakkumised ja registreeritud töötud: graafik
Birma kindralid andsid eile lõpuks abipakkujatele järele / Hendrik Vosman

Index Scriptorium Estoniae

Vosman, Hendrik

2008-01-01

Ilmunud ka: Postimees : na russkom jazõke 20. mai 2008, lk. 9. Birma juhtkond lubas Kagu-Aasia riikide assotsiatsiooni ASEAN erakorralisel nõupidamisel Singapuris, et ühenduse liikmesmaade meditsiinirühmad võivad Birmasse minna. Kaart: ASEANi riigid. Vt. samas: Lapsi varitsevad inimkaubitsejad
Europe's long-term decline is alarming, but not inevitable / Toomas Hendrik Ilves

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2007-01-01

Euroopa Liidu konkurentsivõimest globaliseeruvas maailmas. Autor toob eeskujuks postsovetliku Eesti, kes tegi panuse uusimale infotehnoloogia infrastruktuurile. Euroopa arengusuundadest ning vajadusest ühise energiapoliitika järele. Ilmunud ka: Vaba Eesti Sõna 25. okt. 2007, lk. 12 ja 1. nov. 2007, lk. 12; eesti k. ilmunud ka: Äripäev 1. nov. 2007, lk. 23, pealk.: Euroopat saab aidata ta ise; vene k. ilmunud ka: Den za Dnjom 26. okt. 2007, lk. 26 (tõlk. Jevgenija Unanjants); Delovõje Vedomosti 7. nov. 2007, lk. 14; Ekonomitsheskoje obozrenije - LOGOS-PRESS (Moldova), 26. okt. 2007, nr. 39
Chimäre Mensch?: die Bedeutung der menschlichen Natur in Zeiten der Xenotransplantation = Chimeric human?: the importance of human nature in times of xenotransplantation = Quimera humana?: importância da natureza humana em tempos de xenotransplantes

OpenAIRE

Vieth, Andreas; Quante, Michael

2013-01-01

O artigo reexamina a questão dos xenotransplantes (transplantes de órgãos entre diferentes espécies), tecendo várias observações sobre as práticas de xenotransplantes com o intuito de determinar com precisão o que se entende por xenotransplante (XTP) e de esclarecer em que medida um transplante de animais no organismo humano pode ser denominado uma quimera. Em seguida, os aspectos problemáticos do XTP, desde uma perspectiva ética, embora não sejam abordados no artigo, são nomeados em sua rele...
ETHNOGRAPHIC APPROACH TO EFL/ESL RESEARCH

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Nikolaus Pasassung

2016-10-01

Full Text Available This article shows that ethnography, as an approach, is a very useful tool to be applied in research attempting a good understanding of EFL/ESL classrooms. With reference to work done by anthropologists and classroom researchers, the pre- sent article argues that education, including EFL/ESL classrooms, can be well un- derstood by using ethnographic approaches. This is done by elaborating the rele- vance of ethnography and the classroom context in the sense that ethnographic prin- ciples are applicable in describing and understanding the culture of a classroom, and EFL/ESL teaching in particular.
Kiire liitumine rahaliiduga aitab järele jõuda ELi liidritele / Leszek Balcerowicz

Index Scriptorium Estoniae

Balcerowicz, Leszek

2004-01-01

Ilmunud ka: Delovõje Vedomosti 16. juuni lk. 8. Parim strateegia on liituda eurotsooniga nii ruttu kui võimalik, kuna see ergutab viima lõpule reforme, arvab Poola riigipanga president Leszek Balcerowisz
Radikaalsed palestiinlased tõid Liibanoni taas kodusõja äärele / Arko Olesk

Index Scriptorium Estoniae

Olesk, Arko, 1981-

2007-01-01

Lahingutest äärmusliku palestiinlaste rühmituse Fatah al-Islami ja Liibanoni armee vahel põgenikelaagris Tripoli linna lähedal Liibanoni põhjaosas. Kaart: Lahing põgenikelaagris. Vt. samas: Iisrael võttis sihikule Hamasi kõrgeimad juhid
Vanguardia y violencia en el Cono Sur: Bolaño relee a Arlt

OpenAIRE

Castañeda, Luis H.; Middlebury College

2015-01-01

Este artículo discute la intersección entre vanguardismo y violencia en las obras de Roberto Arlt (El juguete rabioso, Los siete locos/Los lanzallamas) y Roberto Bolaño (Estrella distante). Se empieza por inscribir a Arlt en un vanguardismo caracterizado por la naturaleza violenta y criminal de la fusión vanguardista del arte y la vida. A continuación se analiza, en la novela de Bolaño, la recontextualización neovanguardista y la evaluación ética del vanguardismo arltiano. El artículo concluy...
Maailmas süveneb nõudlus lehtmetallist toodete järele / Ain Alvela

Index Scriptorium Estoniae

Alvela, Ain, 1967-

2007-01-01

Ilmunud ka: Delovõje Vedomosti : Promõshlennost 2. mai lk. 13. AS Favor on oma 17 tegevusaasta vältel teostanud allhankeid, mis on kujunenud tulusaks ja perspektiivseks äriks. Vt. samas: Tooraine tuleb hajutatud kanaleid mööda; Favori neli ärisuunda
Tolkieni järeltulijad nõuavad "Sõrmuste isanda" eest tagantjärele miljoneid

Index Scriptorium Estoniae

2008-01-01

J.R.R. Tolkieni "Sõrmuste isanda" järgi loodud mängufilmide eest nõuavad kirjaniku pärijad kohtu kaudu filmikompaniilt New Line Cinema üle 150 miljoni dollari maksmata jäänud autoriõiguste eest
SOA and Web Technology for Building BSE Market Map

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Claudiu VINTE

2012-01-01

Full Text Available Visual representation as a map of the stock market data can offer access, in a quick and rele-vant manner for human participants, to the overall state of the market at a given point in time. The purpose of this paper is to present the results of our academic research upon building the market map for Bucharest Stock Exchange (BSE. We will focus on the algorithm for generat-ing the market map, the system architecture, and web technology employed for capturing the required data and making the map publicly available through the portal www.bursa.ase.ro. Mathematics Subject Classification: 68M14 (Distributed Systems
Ranking of persister genes in the same Escherichia coli genetic background demonstrates varying importance of individual persister genes in tolerance to different antibiotics

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Nan eWu

2015-09-01

Full Text Available Despite the identification of many genes and pathways involved in the persistence phenomenon of bacteria, the relative importance of these genes in a single organism remains unclear. Here, using Escherichia coli as a model, we generated mutants of 21 known candidate persister genes and compared the relative importance of these mutants in persistence to various antibiotics (ampicillin, gentamicin, norfloxacin, and trimethoprim at different times. We found that oxyR, dnaK, sucB, relA, rpoS, clpB, mqsR, and recA were prominent persister genes involved in persistence to multiple antibiotics. These genes map to the following pathways: antioxidative defense pathway (oxyR, global regulators (dnaK, clpB, and rpoS, energy production (sucB, stringent response (relA, toxin–antitoxin (TA module (mqsR, and SOS response (recA. Among the TA modules, the ranking order was mqsR, lon, relE, tisAB, hipA, and dinJ. Intriguingly, rpoS deletion caused a defect in persistence to gentamicin but increased persistence to ampicillin and norfloxacin. Mutants demonstrated dramatic differences in persistence to different antibiotics at different time points: some mutants (oxyR, dnaK, phoU, lon, recA, mqsR, and tisAB displayed defect in persistence from early time points, while other mutants (relE, smpB, glpD, umuD, and tnaA showed defect only at later time points. These results indicate that varying hierarchy and importance of persister genes exist and that persister genes can be divided into those involved in shallow persistence and those involved in deep persistence. Our findings suggest that the persistence phenomenon is a dynamic process with different persister genes playing roles of variable significance at different times. These findings have implications for improved understanding of persistence phenomenon and developing new drugs targeting persisters for more effective cure of persistent infections.
Laps olla muretuna veel / George Gordon Byron ; tlk. Minni Nurme

Index Scriptorium Estoniae

Byron, George Gordon

2006-01-01

Sisu: Laps olla muretuna veel ; Lachin y Gair ; Romantikale ; Värsid, kirjutatud pärnapuule Harrowþ kalmistu mäel ; Augustale : "Kui süngeks läks mu silmapiir..." ; Augustale : "Kuigi öö ju on varjand mu päeva..." ; Maryle ; Ela hästi! ; Nutvale neitsile ; Kirjutus albumisse ; Hüvastijätt ; Stantsid muusikast ; Muusikale ; Ta oma kauniduses käib ; Mu hing on morn ; Su elu lõppes ; Sa nutsid - pisarpärle täis... ; Unetuma päike ; Kuulsa Kreeka sõjalaulu järele ; Värsid ; Ludiidide laul ; Epigramme ; Pimedus ; Chilloni vang ; Prometheus ; Childe Haroldi palveränd ; Parisina ; Korsaar ; Byroni viimased read. Eluloolisi andmeid autori kohta lk. 327
Information Re-Sharing on Social Network Sites in the Age of Fake News

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Mehrdad Koohikamali

2017-10-01

This study has important practical implications for SNS users and providers alike. Ensuring that information available on SNS is of high quality is critical to maintaining a healthy user base. Findings: Results indicate that attitude toward using SNSs and intention to re-share infor-mation on SNSs is influenced by perceived information quality (enjoyment, rele-vance, and reliability. Also, risk-taking propensity and enjoyment influence the intention to re-share information on SNSs in a positive direction. Future Research: In the dynamic context of SNSs, the role played by quality of information is changing. Understanding changes in quality of information by conducting longitudinal studies and experiments and including the role of habits is necessary.
"Kas su keel kuuleb sind enam..." : [luuletused] / Jaan Kaplinski

Index Scriptorium Estoniae

Kaplinski, Jaan, 1941-

2003-01-01

Sisu: "Kas su keel kuuleb sind enam..." ; "Kui maailm teabki..." ; "Iga kevadega on taevas madalam ja trepid kõrgemad..." ; "Mis on sõnade vahel on aina enam kui sõnad ise..." ; "Palve on nüüd see mis jääb järele..." ; "Keegi ei maga kellegagi sama und..." ; "Niipalju nimesid miska olen nimetanud..." ; "Äkitselt nagu karjatades hakkab vesi kannus keema..." ; "Kui hea on mõelda et kõik see ilu pole kellegi jaoks..." ; "See kelle uni me oleme kuidas ta jättis meid siia..." ; "Enne kui teeme tule ära korjan lambi alt liblikad kokku..." ; "Raamatud pööravad meie poole seljad..." ; "Kõik mis me ehitame ehitame millegi rusudest..."

Kuhu kadus antropoloogia? : ehk vajadus "inimloomuse" järele / Maurice Bloch ; tlk. Maarja Kaaristo

Index Scriptorium Estoniae

Bloch, Maurice

2007-01-01

Antropoloogia kui distsipliini akadeemilisest ajaloost, sotsiaal- ja kultuuriantropoloogia hariduse puudujääkidest. Antropoloogia põhilistest uurimisteemadest ja uurimisteooriatest: difusionismist, evolutsionismist ning funktsionalismist
Why enhance and upgrade the public housing assets

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Lucia Castiglioni

2012-10-01

Full Text Available The enhancement and the upgrading of public housing heritage is considered an example of the rehabilitation’s design potentiality and it is demonstrated through the identification by picking out some rele-vant areas of interest in relation to the built environment. In support of these identified areas examples of European best practices are shown emblematic having a programmatic, cultural and environmental character. The outlined strategies determine management, operational, financial and technological methods that shall permit its use in relation to contemporary dwelling requirement and they are outlin-ing the alternatives usable possibilities in terms of collective, cultural and also economic aspects at the same time. The building rehabilitation is understood as a design tool for the building and urban enhance-ment.
L’enjeu triangulaire de la trame romanesque du Roman d’Enéas

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Catherine Desprès Caubrière

2013-04-01

Full Text Available The heroic path of Aeneas is generally defined by three linear events: his stay in Carthage, his descent into Hell, and the founding of future Rome. However, upon the grounds of the narrative plot, this path is triangular in shape, made up by three points on the map (Troy, Carthage and Laurente which are, respectively, the starting point of his exile, a deviation from it, and his arrival. This triangle, which is rele-vant from the point of view of the interpre-tation, and which was brought about by war, love and power, is expressed within a symbolic geometry, adapted to a tri-functional scheme of the judgement of Paris, as a structure connected with the project of rewriting the middle Ages.
Prosedur Strategis Untuk Mengurangi Level Bahaya Arc-Flash Pada Medium Voltage Dengan Metode Koordinasi Proteksi Di PT Ipmomi Paiton

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inas ratnaning zafirah

2017-01-01

Full Text Available Di area sistem kelistrikan, operasi, dan maintenance, perhatian terbesar adalah keselamatan dan keamanan pekerja yang mengoperasikan dan menjaga sistem. Sistem kelistrikan didisain tidak hanya untuk tindakan pencegahan yang diperlukan pada sistem proteksi dan peralatan, tetapi juga harus memperhatikan keselamatan personal untuk tingkat tertentu dari arc-flash atau busur api karena arcing fault. Pada tugas akhir ini, bahaya busur api akan dianalisis dan diperhitungkan. Hasilnya akan diketahui level energi arc-flash atau busur api yang mungkin terjadi sesuai standar NFPA 70E-2004. Data yang nanti digunakan diambil dari plant yang telah ditentukan sebelumnya yaitu PT IPMOMI. Dari data tersebut, parameter – parameter yang diperlukan akan dihitung dan diketahui level busur api. Bila diperlukan, maka juga akan dilakukan resetting atau penambahan rele over current.
Kas tüdrukud jõuavad järele? Soolise infokihistumise arengujoontest Eestis / Veronika Kalmus

Index Scriptorium Estoniae

Kalmus, Veronika, 1973-

2004-01-01

Sugudevahelistest erinevustest infotehnoloogia kasutamises ning olulise informatsiooni valdamises. 14-19-aastaste noorte seas tehtud küsitlusuuringute tulemustest. Diagrammid: Internetiühenduse olemasolu kodus (%); Interneti märkimisväärne kasutamine (%); Arvutikasutusoskuste keskmised enesehinnangud. Tabelid: Infokihistumise aspektid soo lõikes vanuserühmades 2002-03. a.; Lineaarse regressioonanalüüsi tulemused
Tutela de los menores de edad y libertad de prensa en Francia. El caso de las bandes dessinées

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Ignacio Fernández Sarasola

2012-01-01

Full Text Available The French comic-books have a long tradition, but as they are mainly addressed to youth people, they are subjected to a State control. This control is in the hands of a Commission (Commission de surveillance et de contrôle des publications destinées à l'enfance et à l'adolescence which checks those publications addressed to children and adolescents. Its finality is to protect the youth people from moral corruption. This Commission was created by the Act of 16th June 1949, which was passed in a situation of hostility to the foreign comic-books. This Act establishes important limitations to the Freedom of the Press.La bande dessinée française dispose d’une grande tradition, mais puisque ces œuvres sont principalement destinées aux jeunes, elles sont exposées à une surveillance pour l’Etat. Ce contrôle est effectué par la « Commission de surveillance et de contrôle des publications destinées à l'enfance et à l'adolescence » au nom de la protection de la jeunesse. Sa Commission fut instituée par la loi du 16 juillet 1949; une loi né dans une situation d’hostilité contre les bandes dessinées estrangères et qui établi rele-vant limitations dans la liberté de la presse.
The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins.

Science.gov (United States)

Nolin, James D; Tully, Jane E; Hoffman, Sidra M; Guala, Amy S; van der Velden, Jos L; Poynter, Matthew E; van der Vliet, Albert; Anathy, Vikas; Janssen-Heininger, Yvonne M W

2014-08-01

Interleukin-17A (IL-17A) is a newly emerging player in the pathogenesis of chronic lung diseases that amplifies inflammatory responses and promotes tissue remodeling. Stimulation of lung epithelial cells with IL-17A leads to activation of the transcription factor nuclear factor κB (NF-κB), a key player in the orchestration of lung inflammation. We have previously demonstrated the importance of the redox-dependent posttranslational modification S-glutathionylation in limiting activation of NF-κB and downstream gene induction. Under physiological conditions, the enzyme glutaredoxin 1 (Grx1) acts to deglutathionylate NF-κB proteins, which restores functional activity. In this study, we sought to determine the impact of S-glutathionylation on IL-17A-induced NF-κB activation and expression of proinflammatory mediators. C10 mouse lung alveolar epithelial cells or primary mouse tracheal epithelial cells exposed to IL-17A show rapid activation of NF-κB and the induction of proinflammatory genes. Upon IL-17A exposure, sulfenic acid formation and S-glutathionylated proteins increased. Assessment of S-glutathionylation of NF-κB pathway components revealed S-glutathionylation of RelA (RelA-SSG) and inhibitory κB kinase α (IKKα-SSG) after stimulation with IL-17A. SiRNA-mediated ablation of Grx1 increased both RelA-SSG and IKKα-SSG and acutely increased nuclear content of RelA and tended to decrease nuclear RelB. SiRNA-mediated ablation or genetic ablation of Glrx1 decreased the expression of the NF-κB-regulated genes KC and CCL20 in response to IL-17A, but conversely increased the expression of IL-6. Last, siRNA-mediated ablation of IKKα attenuated nuclear RelA and RelB content and decreased expression of KC and CCL20 in response to IL-17A. Together, these data demonstrate a critical role for the S-glutathionylation/Grx1 redox axis in regulating IKKα and RelA S-glutathionylation and the responsiveness of epithelial cells to IL-17A. Copyright © 2014 Elsevier Inc
Lymphotoxin β receptor activation promotes mRNA expression of RelA and pro-inflammatory cytokines TNFα and IL-1β in bladder cancer cells.

Science.gov (United States)

Shen, Mo; Zhou, Lianlian; Zhou, Ping; Zhou, Wu; Lin, Xiangyang

2017-07-01

The role of inflammation in tumorigenesis and development is currently well established. Lymphotoxin β receptor (LTβR) activation induces canonical and noncanonical nuclear factor (NF)‑κB signaling pathways, which are linked to inflammation‑induced carcinogenesis. In the present study, 5,637 bladder cancer cells were cultured and the activation of LTβR was induced by functional ligand, lymphotoxin (LT) α1β2, and silencing with shRNA. Reverse transcription‑quantitative polymerase chain reaction was utilized to detect the mRNA expression levels of NF‑κB family members RelA and RelB, cytokines including LTα, LTβ, tumor necrosis factor (TNF)α, TNF superfamily member 14, interleukin (IL)‑6 and IL‑1β, and proliferation‑related genes including CyclinD1 and Survivin. The expression of phospho‑p65 was determined by western blotting. Activation of LTβR on bladder cancer 5,637 cells was demonstrated to upregulate the mRNA expression levels of the RELA proto‑oncogene, RelA, by 2.5‑fold compared with unstimulated cells, while no significant change was observed in the RELB proto‑oncogene NF‑κB member mRNA levels. Expression of pro‑inflammatory cytokines tumor necrosis factor (TNF)α and interleukin (IL)‑1β mRNA levels were significantly increased nearly 5‑fold and 1.5‑fold, respectively, following LTβR activation compared with unstimulated cells. The LTβR‑induced upregulation of RelA, TNFα and IL‑1β was decreased by ~33, 27, and 26% respectively when LTβR was silenced via short hairpin RNA. Activation of LTβR had no effect on 5,637 cell growth, despite CyclinD1 and Survivin mRNA levels increasing by ~2.7 and 1.3‑fold, respectively, compared with unstimulated cells. In conclusion, activation of LTβR induced the expression of RelA mRNA levels. LTβR activation might be an important mediator in promoting an inflammatory microenvironment in bladder cancer, via the upregulation of TNFα and IL‑1β mRNA levels. LTβR may
Rein Tammik : Pidu katku ajal = Feast during the plague / Anneli Porri

Index Scriptorium Estoniae

Epner, Eero, 1978-

2007-01-01

Rein Tammiku fotorealistlik pildimaailm on iseseisev organism, mis ajuti genereerib ootamatuid tähenduslikke lühiühendusi. Erinevalt loodusmaalijatest, portreemaalijatest, meremaalijatest ja teistest maalib Rein Tammik pilte. Ta on pildimaalija. Tammikut huvitavad eelkõige visuaalsed paradoksid. Tammik asus juba 1970. aastail ajastuid ühte pilti kokku keevitama. Rembrandti grupiportreele «Kangrute gildi eesistujaist» ilmusid «Visarite» näod, Manet’ «Eine murul» leidis järsku aseme punaruudulisel linal jne. Historitsistlik eklektika - postmodernismi peamisi strateegiaid - on Tammiku loomingus täiesti selgelt loetav, teda on nimetatud esimeseks nõukogude postmodernistiks. Teatav nõukogude ajastu traumaatiline tajumine ilmneb tema töödes suuresti igatsusest kestvuse, jätkuvuse ja üldkehtivuse järele, mida 1970-1980-ndad aastad ei võimaldanud. 1992. aastast resideerub Prantsusmaal
Sobre mitos antiguos y héroes modernos: Una relectura de La Historia Interminable a partir de El héroe de las mil caras

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María del Carmen Jiménez Ariza

2013-12-01

Full Text Available La “crítica mítica” es una corriente de análisis que, desde una perspectiva antropológica, estudia los mitos y símbolos presentes en la literatura y en los cuentos populares. Joseph Campbell, uno de los máximos exponentes de este movimiento, explica los grandes mitos a partir del concepto junguiano de inconsciente colectivo, entendido éste como el sustrato simbólico de carácter ancestral que se constituye en influencia universal y es recurrente en todas las civilizaciones. La Historia interminable, obra mundialmente conocida de Michael Ende, puede ser releída bajo el prisma de las teorías de Campbell, en un intento de corroborar que los arquetipos siguen presentes en las manifestaciones culturales de la humanidad.
Sušárny uzenin

OpenAIRE

Čermák, Lubomír

2008-01-01

Tato práce je věnována základním požadavkům technologie sušení a zrání masných výrobků ve zracích komorách. Bude zmíněno základní rozdělení salámů a z toho plynoucí parametry pro zrací komory a jak ovlivňuje hygiena a sanitace celkovou produktivitu. Podrobně bude popsána technologie sušení. Stručně bude popsána fermentace a zrání jako takové. The thesis deals with essential requirements to dry and cure meat products using drying chambers. It covers the basic salami classification, the rele...
Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.

Science.gov (United States)

Miraghazadeh, Bahar; Cook, Matthew C

2018-01-01

NF-κB (nuclear factor-kappa B) is a transcription complex crucial for host defense mediated by innate and adaptive immunity, where canonical NF-κB signaling, mediated by nuclear translocation of RelA, c-Rel, and p50, is important for immune cell activation, differentiation, and survival. Non-canonical signaling mediated by nuclear translocation of p52 and RelB contributes to lymphocyte maturation and survival and is also crucial for lymphoid organogenesis. We outline NF-κB signaling and regulation, then summarize important molecular contributions of NF-κB to mechanisms of self-tolerance. We relate these mechanisms to autoimmune phenotypes described in what is now a substantial catalog of immune defects conferred by mutations in NF-κB pathways in mouse models. Finally, we describe Mendelian autoimmune syndromes arising from human NF-κB mutations, and speculate on implications for understanding sporadic autoimmune disease.
Analisis Kerja Rele Overall Differential pada Generator Unit I PLTA Ketenger PT Indonesia Power UBP Mrica

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Hari Prasetijo

2010-02-01

Full Text Available Plant has two important equipment that are the generator and transformer. Therefore, it should be protected well by the overall differential relay. This relay must be reliable from the disturbances that might arise. In this study a simulation was conducted to obtain and test the overall differential relay setting at generator unit 1 PLTA Ketenger. Modelling was done with MATLAB Simulink 7.0.1 to check the overall differential relay protection system from potentialproblems. The model was given several disturbances, namely 1 short circuit fault in the security area, 2 short circuit fault outside the security area, and 3 lightning disturbances when damaged arrester. From the simulation results, the overall differential relay operating current is 1.73 A (primary side and 1.64 A (secondary side. The results show that the overall differential relay provides a good response, except in the lightning fault with a current above 9x109 A (going the mismatch. For handlingthis problem another arrester should be added.
Managing corneal foreign bodies in office-based general practice.

Science.gov (United States)

Fraenkel, Alison; Lee, Lawrence R; Lee, Graham A

2017-03-01

Patients with a corneal foreign body may first present to their general practitioner (GP). Safe and efficacious management of these presentations avoids sight-threatening and eye-threatening complications. Removal of a simple, superficial foreign body without a slit lamp is within The Royal Australian College of General Practitioners' (RACGP's) curriculum and scope of practice. Knowing the rele-vant procedural skills and indications for referral is equally important. The objective of this article is to provide an evidence-based and expert-based guide to the management of corneal foreign bodies in the GP's office. History is key to identifying patient characteristics and mechanisms of ocular injury that are red flags for referral. Examination tech-niques and methods of superficial foreign body removal without a slit lamp are outlined, as well as the procedural threshold for referral to an ophthalmologist.
The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii.

Science.gov (United States)

Ghafourian, Sobhan; Good, Liam; Sekawi, Zamberi; Hamat, Rukman Awang; Soheili, Sara; Sadeghifard, Nourkhoda; Neela, Vasanthakumari

2014-07-01

Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates. The aim of the current study was to screen for functional TA systems among clinical isolates of A. baumannii and to identify the systems' locations. For this purpose, we screened 85 A. baumannii isolates collected from different clinical sources for the presence of the mazEF, relBE and higBA TA genes. The results revealed that the genes coding for the mazEF TA system were commonly present in all clinical isolates of A. baumannii. Reverse transcriptase-polymerase chain reaction analysis showed that transcripts were produced in the clinical isolates. Our findings showed that TA genes are prevalent, harboured by chromosomes and transcribed within A. baumannii. Hence, activation of the toxin proteins in the mazEF TA system should be investigated further as an effective antibacterial strategy against this bacterium.
c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.

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Victoria Florea

Full Text Available The proto-oncogene c-Myc is vital for vascular development and promotes tumor angiogenesis, but the mechanisms by which it controls blood vessel growth remain unclear. In the present work we investigated the effects of c-Myc knockdown in endothelial cell functions essential for angiogenesis to define its role in the vasculature. We provide the first evidence that reduction in c-Myc expression in endothelial cells leads to a pro-inflammatory senescent phenotype, features typically observed during vascular aging and pathologies associated with endothelial dysfunction. c-Myc knockdown in human umbilical vein endothelial cells using lentivirus expressing specific anti-c-Myc shRNA reduced proliferation and tube formation. These functional defects were associated with morphological changes, increase in senescence-associated-β-galactosidase activity, upregulation of cell cycle inhibitors and accumulation of c-Myc-deficient cells in G1-phase, indicating that c-Myc knockdown in endothelial cells induces senescence. Gene expression analysis of c-Myc-deficient endothelial cells showed that senescent phenotype was accompanied by significant upregulation of growth factors, adhesion molecules, extracellular-matrix components and remodeling proteins, and a cluster of pro-inflammatory mediators, which include Angptl4, Cxcl12, Mdk, Tgfb2 and Tnfsf15. At the peak of expression of these cytokines, transcription factors known to be involved in growth control (E2f1, Id1 and Myb were downregulated, while those involved in inflammatory responses (RelB, Stat1, Stat2 and Stat4 were upregulated. Our results demonstrate a novel role for c-Myc in the prevention of vascular pro-inflammatory phenotype, supporting an important physiological function as a central regulator of inflammation and endothelial dysfunction.
Studi Perencanaan Koordinasi Proteksi Mempertimbangkan Busur Api Pada Sistem Kelistrikan PT. Semen Indonesia Aceh Menggunakan Standar IEEE 1584-2002

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Dhimas Oktavian Andryana

2017-03-01

Full Text Available PT. Semen Indonesia pabrik Aceh merupakan perusahaan patungan (joint venture company antara PT. Semen Indonesia (Persero bersama PT. Samana Citra Agung. Total daya listrik yang dibutuhkan sebesar 85.8 MW dengan sistem kelistrikan pada sistem tegangan rendah dan menengah. Guna menjaga kontinuitas daya listrik, diperlukan koordinasi proteksi untuk meminimalisir dampak yang ditimbulkan ketika terjadi gangguan. Salah satu dampak yang ditimbulkan adalah adanya busur api (arc flash. Namun demikian, energi yang dihasilkan oleh busur api setelah dilakukan koordinasi proteksi perlu dipertimbangkan agar tidak melampaui standard yang diizinkan. Analisa busur api dilakukan dengan menggunakan perhitungan standar IEEE 1584-2002. Setelah dilakukan beberapa analisa didapatkan bahwa beberapa daerah di PT. Semen Indonesia pabrik Aceh memiliki nilai insiden energi diatas kategori 4, sehingga diperlukan tambahan peralatan berupa rele differensial sebagai pengaman utama agar nilai insiden energi busur api bisa dikategorikan sesuai standard NFPA 70E.
Fractionation and identification of novel antioxidant peptides from buffalo and bovine casein hydrolysates.

Science.gov (United States)

Shazly, Ahmed Behdal; He, Zhiyong; El-Aziz, Mahmoud Abd; Zeng, Maomao; Zhang, Shuang; Qin, Fang; Chen, Jie

2017-10-01

Buffalo and bovine caseins were hydrolysed by alcalase and trypsin to produce novel antioxidant peptides. The casein hydrolysates were purified using ultrafiltration (UF) and further characterized by RP-HPLC. The fractions produced higher antioxidant activities were identified for their peptides using LC MS/MS. All UF-VI (MWcasein (UF-VI with 54.84-fold purification) showed higher antioxidant activity than that obtained by trypsin. Trypsin hydrolysate contained high amount of hydrophobic amino acids while alcalase hydrolysate consisted mainly of Ser, Arg, Ala and Leu. The antioxidant peptides identified by LC MS/MS were RELEE, MEDNKQ and TVA, EQL in buffalo casein hydrolysates produced by trypsin and alcalase, respectively. Mechanism and reaction pathways of selected antioxidant peptides with ABTS were proposed. Conclusively, buffalo casein provided antioxidant peptides similar to bovine, suggesting that buffalo casein is a novel source of antioxidant. Copyright © 2017 Elsevier Ltd. All rights reserved.
Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA

DEFF Research Database (Denmark)

Christensen, S.K.; Pedersen, K.; Hansen, Flemming G.

2003-01-01

Prokaryotic chromosomes encode toxin-antitoxin loci, often in multiple copies. In most cases, the function of these genes is not known. The chpA (mazEF) locus of Escherichia coli has been described as a cell killing module that induces bacterial apoptosis during nutritional stress. However, we...... found recently that ChpAK (MazF) does not confer cell killing but rather, induces a bacteriostatic condition from which the cells could be resuscitated. Results presented here yield a mechanistic explanation for the detrimental effect on cell growth exerted by ChpAK and the homologous ChpBK protein of E......AK cleaved tmRNA in its coding region. Thus, ChpAK and ChpBK inhibit translation by a mechanism very similar to that of E. coli RelE. On the basis of these results, we propose a model that integrates TA loci into general prokaryotic stress physiology....
The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii

Directory of Open Access Journals (Sweden)

Sobhan Ghafourian

2014-07-01

Full Text Available Although analysis of toxin-antitoxin (TA systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates. The aim of the current study was to screen for functional TA systems among clinical isolates of A. baumannii and to identify the systems’ locations. For this purpose, we screened 85 A. baumannii isolates collected from different clinical sources for the presence of the mazEF, relBE and higBA TA genes. The results revealed that the genes coding for the mazEF TA system were commonly present in all clinical isolates of A. baumannii. Reverse transcriptase-polymerase chain reaction analysis showed that transcripts were produced in the clinical isolates. Our findings showed that TA genes are prevalent, harboured by chromosomes and transcribed within A. baumannii. Hence, activation of the toxin proteins in the mazEF TA system should be investigated further as an effective antibacterial strategy against this bacterium.

A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis.

Science.gov (United States)

Sun, Hui; Kamanova, Jana; Lara-Tejero, Maria; Galán, Jorge E

2016-03-01

Microbial infections usually lead to host innate immune responses and inflammation. These responses most often limit pathogen replication although they can also result in host-tissue damage. The enteropathogenic bacteria Salmonella Typhimurium utilizes a type III secretion system to induce intestinal inflammation by delivering specific effector proteins that stimulate signal transduction pathways resulting in the production of pro-inflammatory cytokines. We show here that a family of related Salmonella Typhimurium effector proteins PipA, GogA and GtgA redundantly target components of the NF-κB signaling pathway to inhibit transcriptional responses leading to inflammation. We show that these effector proteins are proteases that cleave both the RelA (p65) and RelB transcription factors but do not target p100 (NF-κB2) or p105 (NF-κB1). A Salmonella Typhimurium strain lacking these effectors showed increased ability to stimulate NF-κB and increased virulence in an animal model of infection. These results indicate that bacterial pathogens can evolve determinants to preserve host homeostasis and that those determinants can reduce the pathogen's virulence.
ANÁLISIS DEL EQUILIBRIO ENTRE EL POTENCIAL TURÍSTICO Y LA OFERTA DE ALOJAMIENTOS EN TURISMO RURAL MEDIANTE T ÉCNICAS DE ESTADÍSTICA ESPACIAL. UNA APLICACIÓN A LA PROVINCIA DE CÁCERES (ESPAÑA

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José Manuel Sánchez Martín

2017-01-01

Full Text Available La distribución de la oferta de alojamiento rural se concentra en espacios muy concretos coincidentes, en buena parte de los casos, con la presencia de los atractivos naturales más rele - vantes. Entre ellos destacan el relieve y la red hidrográfica como elementos preferidos por la demanda. No obstante, parte de la oferta alojativa se localiza en áreas con menos aptitudes para desarrollar esta modalidad turística. Por ello, proponemos realizar un análisis que nos permita determinar la bondad de la adecuación entre la oferta y el atractivo turístico mediante la uti - lización de estadística espacial. En concreto, se propone utilizar la regresión geográficamente ponderada y su modelo de ajuste para determinar si los alojamientos se localizan en las zonas idóneas o, por el contrario, están en áreas menos adecuadas para la práctica del turismo rural.
EFFECT OF 2008 AND 2016 U.S. PRESIDENTIAL ELECTION IN THE INDONESIAN STOCK MARKET

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Evelyn Evelyn

2018-03-01

Full Text Available The U.S. Presidential election was an event that received widespread attention across the globe. In the 2008 presidential campaign, Barrack Obama nominated to be the first black President. In 2016, Hillary Clinton potentially becomes the first woman President in American history, while the other candidate, Donald Trump, made some unpopular and controversial proposals. The purpose of this paper is to analyse whether the 2008 and 2016 election were considered as the relevant information in the Indonesian Stock Market (IDX. The daily closing prices of all all share listed in IDX would be examined used event study method. The results provide insight about the responsiveness of IDX participants to the U.S. Presidential election event that could be used in decision making.
Appihüüd märkamise ja mõistmise järele / Mare Tuisk ; intervjueerinud Karl Kello

Index Scriptorium Estoniae

Tuisk, Mare

2002-01-01

Intervjuu koolipsühholoogiga, kes oma magistritöös "Käitumisprobleemid esimese ja teise kooliastme õpilaste vajaduste ja emotsioonide kontekstis" uuris käitumishäiretega laste probleeme: põhjuseks bioloogiliste vajaduste, turvalisus-, kuuluvus-, tunnustus- ja eneseteostusvajaduse mitterahuldatus
Sündinud vajadusest õhu ja hingamise järele / Jukka Pennanen, Mace Ojala ; soome keelest tõlkinud Triinu Seppam

Index Scriptorium Estoniae

Pennanen, Jukka

2012-01-01

"Jalgrattasõit raamatukogude eest Balti iikides 2012 ("Cycling for Libraries in the Baltic States 2012") toimus 28. juulist 7. augustini 2012, kus erinevate maade raamatukoguhoidjad ja raamatusõbrad külastasid Eesti, Läti ja Leedu raamatukogusid
Bruk av språk og diskusjoner for å fremme elevers forståelse i kvantefysikk gjennom digitale ressurser

Directory of Open Access Journals (Sweden)

Berit Bungum

2016-04-01

Full Text Available In the project ReleQuant, we develop digital teaching resources for modern physics in upper secondary schools in Norway, and investigate students’ learning processes by means of Educational Design Research. The resources are developed within a sociocultural view of learning, and emphasise students’ use of language. In this paper we investigate how students understand two key principles in quantum physics, quantization and the wave-particle duality, and how students’ use of qualitative written language and peer discussions contribute to deepening their understanding of these principles. Data material is gathered from seven physics classes at five different schools. The results expose a number of misconceptions among students, and show that the use of language is important in order to reveal these misconceptions. However, if the authoritative voice of the teacher is not represented, the value of the discussions in developing students’ conceptions may be limited. Based on these results, we point to critical points where teachers should intervene with students in order to support their learning. We also document how the results have led to improvements in the teaching resources.
Icarus

CERN Document Server

Montanari, Claudio

2015-01-01

ICARUS T600 Liquid Argon Time Projection Chamber is the first large mass (760 tons) exam- ple of a new generation of detectors able to combine the imaging capabilities of the old famous bubble chamber with the excellent energy measurement of electronic detectors. In 2013 ICARUS concluded a very successful, long duration run with the T600 detector at the LNGS underground laboratory taking data both with the CNGS neutrino beam and with cosmic rays. Several rele- vant physics and technical results were achieved. A joint ICARUS/SBND/MicroBooNE effort is taking place to develop a collaborative, international program at FNAL’s Booster Neutrino Beam (and NuMI off-axis) with three detectors at different baselines by 2018 (near: SBND, mid: Mi- croBooNE, far: ICARUS). The T600 detector was transported to CERN at the end of 2014 for a series of upgrades before being taken to FNAL. The refurbishment operations, inside the WA104 programme at CERN, of the Icarus T600 detector will be outlined, with an introduction to the...
El canon literario andino desde los estudios de género: cargar con el peso de la hetero(maricageneidad contradictoria. El caso de Pablo Palacio

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Diego Falconí Trávez

2015-11-01

Full Text Available Este artículo busca realizar una crítica desde los estudios de género respecto a la noción de canon literario heterocentrado en la zona andina. Para ello, relee tanto a la crítica nacional como a aquella regional respecto a sus construcciones en torno al ecuatoriano Pablo Palacio, escritor icónico de la vanguardia de los años 30, centrándose en dos nociones. En primer lugar, en la idea, elaborada desde la crítica literaria ecuatorianista, de la relación posicional y gráfica de un hombre que carga a otro, cuestión que ha servido para elaborar una dicotomía vertical y patriarcal en el análisis teórico que contrapone realismo social y cosmopolitismo. Y en segundo, en el concepto regional de sujeto heterogéneo y contradictorio, propuesto por Antonio Cornejo Polar que articulándose en la etnia, la clase y el estatus colonial deja, sin embargo, de lado la diferencia sexo-genérica.
Studi Pengaman Busbar Pada Gardu Induk Amlapura

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I Made Dian Purnawan

2016-06-01

Full Text Available Busbar safety is a protection system that plays an important role in securing the disruption of the busbar itself. This protection system should work in a sensitive, selective, rapid, and must be stable to disturbance outside the region busbar protection. At the substation Amlapura, if one busbar impaired or absence of the busbar securing safety as on the other substation, will lead to an imbalance perceived by the system and can lead to continuity of power flow can be disrupted. Based on the calculations that have been done shows that for short circuit simulation results busbar A and B obtained Amlapura substation fault current that occurs in the amount of 5.538 kA. For the calculation of the impedance zone 1 (80% primer is 1.9721 + 5.715 ? A Zsekunder with a time delay of 0 seconds or work instantly, Zone 2 (120% primer is 5.55 ? Z + J 16.0836 primary, Zone 2 (120% the secondary is 2.958 + J 8.5726 ? Zsekunder with a time delay of 0.4 seconds. Keywords: Busbar, Rele, Short Circuit Analysis, impedance
TNF-α and IL-1β Dependent Induction of CCL3 Expression by Nucleus Pulposus Cells Promotes Macrophage Migration through CCR1

Science.gov (United States)

Wang, Jianru; Tian, Ye; Phillips, Kate L.E.; Chiverton, Neil; Haddock, Gail; Bunning, Rowena A.; Cross, Alison K.; Shapiro, Irving M.; LeMaitre, Christine L.; Risbud, Makarand V.

2012-01-01

Objective To investigate TNF-α and IL-1β regulation of CCL3 expression in nucleus pulposus (NP) cells and in macrophage migration. Methods qRT-PCR and immunohistochemistry were used to measure CCL3 expression in NP cells. Transfections were used to determine the role of NF-κB, C/EBP-β and MAPK on cytokine mediated CCL3 promoter activity. Effect of NP-conditioned medium on macrophage migration was measured using a transwell system. Results An increase in CCL3 expression and promoter activity was observed in NP cells after TNF-α or IL-1β treatment. Treatment of cells with NF-κB and MAPK inhibitors abolished the effect of the cytokines on CCL3 expression. The inductive effect of p65 and C/EBP-β on CCL3 promoter was confirmed through gain- and loss-of-function studies. Noteworthy, co-transfection of p50 completely blocked cytokine and p65 dependent induction. In contrast, c-Rel and RelB had little effect on promoter activity. Lentiviral transduction with Sh-p65 and Sh-Ikkβ significantly decreased TNF-α dependent increase in CCL3 expression. Analysis of degenerate human NP tissues showed that CCL3, but not CCL4 expression correlated positively with the grade of tissue degeneration. Importantly, treatment of macrophages with conditioned medium of NP cells treated with TNF-α or IL-1β promoted their migration; pretreatment of macrophages with antagonist to CCR1, primary receptor for CCL3 and CCL4, blocked cytokine mediated migration. Conclusions By controlling the activation of MAPK, NF-κB and C/EBPβ signaling, TNF-α and IL-1β modulate the expression of CCL3 in NP cells. The CCL3-CCR1 axis may play an important role in promoting macrophage infiltration in degenerate, herniated discs. PMID:23233369
Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability.

Science.gov (United States)

Zago, Michela; Sheridan, Jared A; Traboulsi, Hussein; Hecht, Emelia; Zhang, Yelu; Guerrina, Necola; Matthews, Jason; Nair, Parameswaran; Eidelman, David H; Hamid, Qutayba; Baglole, Carolyn J

2017-01-01

Heightened inflammation, including expression of COX-2, is associated with chronic obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is reduced in COPD-derived lung fibroblasts. The AhR also suppresses COX-2 in response to cigarette smoke, the main risk factor for COPD, by destabilizing the Cox-2 transcript by mechanisms that may involve the regulation of microRNA (miRNA). Whether reduced AhR expression is responsible for heightened COX-2 in COPD is not known. Here, we investigated the expression of COX-2 as well as the expression of miR-146a, a miRNA known to regulate COX-2 levels, in primary lung fibroblasts derived from non-smokers (Normal) and smokers (At Risk) with and without COPD. To confirm the involvement of the AhR, AhR knock-down via siRNA in Normal lung fibroblasts and MLE-12 cells was employed as were A549-AhRko cells. Basal expression of COX-2 protein was higher in COPD lung fibroblasts compared to Normal or Smoker fibroblasts but there was no difference in Cox-2 mRNA. Knockdown of AhR in lung structural cells increased COX-2 protein by stabilizing the Cox-2 transcript. There was less induction of miR-146a in COPD-derived lung fibroblasts but this was not due to the AhR. Instead, we found that RelB, an NF-κB protein, was required for transcriptional induction of both Cox-2 and miR-146a. Therefore, we conclude that the AhR controls COX-2 protein via mRNA stability by a mechanism independent of miR-146a. Low levels of the AhR may therefore contribute to the heightened inflammation common in COPD patients.
Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway.

Directory of Open Access Journals (Sweden)

Nan-Sun Kim

Full Text Available A chimeric protein vaccine composed of the cholera toxin B subunit fused to proinsulin (CTB-INS was shown to suppress type 1 diabetes onset in NOD mice and upregulate biosynthesis of the tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1 in human dendritic cells (DCs. Here we demonstrate siRNA inhibition of the NF-κB-inducing kinase (NIK suppresses vaccine-induced IDO1 biosynthesis as well as IKKα phosphorylation. Chromatin immunoprecipitation (ChIP analysis of CTB-INS inoculated DCs showed that RelB bound to NF-κB consensus sequences in the IDO1 promoter, suggesting vaccine stimulation of the non-canonical NF-κB pathway activates IDO1 expression in vivo. The addition of Tumor Necrosis Factor Associated Factors (TRAF TRAF 2, 3 and TRAF6 blocking peptides to vaccine inoculated DCs was shown to inhibit IDO1 biosynthesis. This experimental outcome suggests vaccine activation of the TNFR super-family receptor pathway leads to upregulation of IDO1 biosynthesis in CTB-INS inoculated dendritic cells. Together, our experimental data suggest the CTB-INS vaccine uses a TNFR-dependent signaling pathway of the non-canonical NF-κB signaling pathway resulting in suppression of dendritic cell mediated type 1 diabetes autoimmunity.
Control rod position control device

International Nuclear Information System (INIS)

Ubukata, Shinji.

1997-01-01

The present invention provides a control rod position control device which stores data such as of position signals and driving control rod instruction before and after occurrence of abnormality in control for the control rod position for controlling reactor power and utilized the data effectively for investigating the cause of abnormality. Namely, a plurality of individual control devices have an operation mismatching detection circuit for outputting signals when difference is caused between a driving instruction given to the control rod position control device and the control rod driving means and signals from a detection means for detecting an actual moving amount. A general control device collectively controls the individual control devices. In addition, there is also disposed a position storing circuit for storing position signals at least before and after the occurrence of the control rod operation mismatching. With such procedures, the cause of the abnormality can be determined based on the position signals before and after the occurrence of control rod mismatching operation stored in the position storing circuit. Accordingly, the abnormality cause can be determined to conduct restoration in an early stage. (I.S.)
OFFLINE

CERN Multimedia

L. Sexton-Kennedy

2012-01-01

Introduction At the very end of data-taking in 2011, the LHC delivered a few stores with very high instantaneous luminosity. These data were extremely useful for Offline. With it, we could measure that the performance of the reconstruction application in CMSSW_4_4_X on these data was just as taxing on computing resources as the CMSSW_4_2_X release was on run 2011B data. We also learned that the response predicted by high pile-up simulation did not match the technical performance of the reconstruction on these data. This prompted a significant change in Offline release planning. We had hoped that the 5_0_X release series would be used in 2012 data-taking. This would have given CMS plenty of time to validate it and prepare analyses for using it. Instead we had to call for another performance task force, the PPT, and ask the collaboration to chip in and improve performance by another factor of two. As of this CMS Week we have had many valuable contributions, which have been integrated into the CMSSW_5_2_X rele...
Educators as action researchers: some key considerations

Directory of Open Access Journals (Sweden)

Daneel Rossouw

2009-02-01

Full Text Available A characteristic of expert educators is their ability to interpret classroom activities critically, to identify and solve problems regarding their teaching practice, and to make thoughtful or reflective instructional and classroom management decisions that are conducive to learning. For educators to be efficacious, they should be active participants in the classroom and observers of the learning and teaching processes, assessing and interpreting the data forthcoming from the classroom and using that knowledge, together with more academic or public theory and research, as a basis for planning and decision-making. Action research provides educators with a strategy to enhance their reflective teaching practice, thereby sharpening their understanding of instruction and improving their instructional and classroom management skills, thus promoting educational change. In this article I discuss an action research model for educators to assist them in finding alternatives to current practice by gathering data and using the data to create meaning, which is then fed back into the system with a view to improved action. The proposed action research model is highly relevant to pre-service and in-service teacher training.
Analisa Arc Flash Pada Sistem Kelistrikan Di PT. Wilmar Nabati Indonesia, Gresik – Jawa Timur

Directory of Open Access Journals (Sweden)

Aditya Aji Nugroho

2017-03-01

Full Text Available Studi untuk mengetahui besar busur api yang dihasilkan pada masing-masing switchgear perlu dilakukan untuk mengklasifikasikan kategori energi busur api yang terjadi serta kaitannya dengan PPE (Personal Protective Equipment yang harus dikenakan pekerja sebagai langkah pencegahan agar terhindar dari jatuhnya korban jiwa. Oleh karena itu perlu dilakukan perhitungan insiden energi arc flash sesuai standar IEEE 1584-2002 serta pengklasifikasian kategori dan alat perlindungan diri yang tepat agar memberikan rasa aman dan nyaman bagi para pekerja sehingga dapat bekerja secara optimal. Studi ini akan coba diterapkan pada sistem kelistrikan di PT. Wilmar Nabati Indonesia, Gresik – Jawa Timur mengingat pentingnya perusahaan tersebut mengamankan peralatan serta pekerjanya dari insiden energy arc flash. Hasil yang didapat pada tugas akhir ini adalah pada tipikal 1 nilai insiden energinya mengalami peningkatan yaitu dari 1.988 cal/cm2 menjadi 8.66 cal/cm2, pada tipikal 2 nilai insiden energi tertinggi 19.596 cal/cm2 turun menjadi 6.00 cal/cm2, pada tipikal 3 nilai insiden energi nya mengalami peningkatan yaitu dari 19.596 cal/cm2 menjadi 36.52 cal/cm2 kenaikan ini disebabkan karena terjadi kesalahan koordinasi rele.
Cibercultura: una forma contemporánea de comunicación multimedia

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Julio Ernesto Rojas Mesa

2012-01-01

Full Text Available Día tras día se consolida una perspectiva contemporánea de las cons- trucciones de sociedad, cultura y conocimiento. La revolución de las tecnologías de la información y la comunicación (TIC ha transfor mado de manera radical la visión de lo humano y su relación con el entorno , c on sus congéneres y consigo mismo. La consolidación de enfoques culturales en la construcción de nuevas narrativ as de lo global y lo local y en las r epresentaciones políticas, económicas, sociales y territor iales de las sociedades per mite hablar del fenómeno ciber y, especialmente , de una no vedosa manera de comunicación multimedia e interac ción de nuestr as sociedades. Este texto pretende aportar a la rele xión de dicho f enómeno a partir del análisis de la cibercultura, en tanto escenario par a en tender la multiplicidad y multimedialidad del sujeto contemporáneo .
Chillida y la realidad : ¿un nuevo romanticismo?

Directory of Open Access Journals (Sweden)

Begoña Fernández Cabaleiro

1998-01-01

Full Text Available El arte del romanticismo es la expresión de una sensibilidad que se libera de las reglas establecidas con el fin de buscar nuevas fuentes de inspiración. Esto lleva al artista a buscar nuevos caminos a través de la naturaleza. A finales del siglo XX el hombre vive una situación de vértigo. El arte surge como una vía de transfiguración. Eduardo Chillida parte de la realidad. La relee y la expresa de un modo nuevo. Agua, luz, espacio, sonido; hombre y libertad; espíritu y materia son de nuevo descubiertas y manifestadas en su obra.Romanticize art was a way of sensibility without regulation; It wanted to look for new inspiration ways. The artist looked into the Nature. At the end of XXth century, the man lives a difficult situation.The art borns as a way of change. Eduardo Chillida begins in the reality. He studies it and he makes it in a new way. Water, light, space, sound; Man and liberty; mind and matter are discovered again in his work.
Start-up date announced

CERN Multimedia

7th August 2008. CERN has announced that the first attempt to circulate the beam in the LHC will be made on the 10th September. This news comes as the cool down phase of commissioning the accelerator reaches a successful conclusion.The next phase is the synchronization of the LHC with the SPS accelerator, the last link in the LHC’s injector chain. A first synchronization test is scheduled for the 9th August, for the clockwise circulating beam, with the second to follow over the coming weeks.Once stable circulating beams have been established in September they will be brought to collision, and the final step will be to commission the LHC’s acceleration system to boost the energy to 5 TeV, the target energy for 2008.“We’re finishing a marathon with a sprint”, said LHC project leader Lyn Evans. “It’s been a long haul, and we’re all eager to get the LHC research programme underway.”For more information, please see the recent press release at: http://press.web.cern.ch/press/PressReleases/Rele...
Kunst.ee toimetaja: tihti mõistame teose väärtust üksnes tagantjärele / Andreas Trossek ; intervjueerinud Kaarel Kressa

Index Scriptorium Estoniae

Trossek, Andreas, 1980-

2009-01-01

Eesti kunsti ja visuaalkultuuri ajakirja Kunst.ee peatoimetaja ajakirja toimetusepõhisele töömudelile üleminekust, ajakirja sisulistest ja vormilistest muudatustest. Kunstikriitika mahu vähenemisest Eesti meedias. Kunstnike teostest, mida iseloomustab julgus püstitada ebamugavaid küsimusi, Kristina Normani "Kuldsõdurist"

Carbon and nitrogen uptake of calcareous benthic foraminifera along a depth-related oxygen gradient in the OMZ of the Arabian Sea

Directory of Open Access Journals (Sweden)

Annekatrin Julie Enge

2016-02-01

Full Text Available Foraminifera are an important faunal element of the benthos in oxygen-depleted settings such as Oxygen Minimum Zones (OMZs where they can play a relevant role in the processing of phytodetritus. We investigated the uptake of phytodetritus (labeled with 13C and 15N by cal-careous foraminifera in the 0-1 cm sediment horizon under different oxygen concentrations within the OMZ in the eastern Arabian Sea. The in situ tracer experiments were carried out along a depth transect on the Indian margin over a period of 4 to 10 days. The uptake of phy-todetrital carbon within 4 days by all investigated species shows that phytodetritus is a rele-vant food source for foraminifera in OMZ sediments. The decrease of total carbon uptake from 540 to 1100 m suggests a higher demand for carbon by species in the low-oxygen core region of the OMZ or less food competition with macrofauna. Especially Uvigerinids showed high uptake of phytodetrital carbon at the lowest oxygenated site. Variation in the ratio of phytodetrital carbon to nitrogen between species and sites indicates that foraminiferal carbon and nitrogen use can be decoupled and different nutritional demands are found between spe-cies. Lower ratio of phytodetrital carbon and nitrogen at 540 m could hint for greater demand or storage of food-based nitrogen, ingestion or hosting of bacteria under almost anoxic condi-tions. Shifts in the foraminiferal assemblage structure (controlled by oxygen or food availabil-ity and in the presence of other benthic organisms account for observed changes in the pro-cessing of phytodetritus in the different OMZ habitats. Foraminifera dominate the short-term processing of phytodetritus in the OMZ core but are less important in the lower OMZ bounda-ry region of the Indian margin as biological interactions and species distribution of foraminif-era change with depth and oxygen levels.
Minimum energy control and optimal-satisfactory control of Boolean control network

International Nuclear Information System (INIS)

Li, Fangfei; Lu, Xiwen

2013-01-01

In the literatures, to transfer the Boolean control network from the initial state to the desired state, the expenditure of energy has been rarely considered. Motivated by this, this Letter investigates the minimum energy control and optimal-satisfactory control of Boolean control network. Based on the semi-tensor product of matrices and Floyd's algorithm, minimum energy, constrained minimum energy and optimal-satisfactory control design for Boolean control network are given respectively. A numerical example is presented to illustrate the efficiency of the obtained results.
Hierarchical Control of Thermostatically Controller Loads for Primary Frequency Control

DEFF Research Database (Denmark)

Zhao, Haoran; Wu, Qiuwei; Huang, Shaojun

2016-01-01

reserve references. At the middle level, distribution substations estimate the available power of TCLs based on the aggregated bin model, and dispatch control signals to individual TCLs. At the local level, a supplementary frequency control loop is implemented at the local controller, which makes TCLs...... respond to the frequency event autonomously. Case studies show that the proposed controller can efficiently respond to frequency events and fulfill the requirement specified by the system operator. The users’ comforts are not compromised and the short cycling of TCLs is largely reduced. Due...... to the autonomous control, the communication requirement is minimized....
Incoherent control of locally controllable quantum systems

International Nuclear Information System (INIS)

Dong Daoyi; Zhang Chenbin; Rabitz, Herschel; Pechen, Alexander; Tarn, T.-J.

2008-01-01

An incoherent control scheme for state control of locally controllable quantum systems is proposed. This scheme includes three steps: (1) amplitude amplification of the initial state by a suitable unitary transformation, (2) projective measurement of the amplified state, and (3) final optimization by a unitary controlled transformation. The first step increases the amplitudes of some desired eigenstates and the corresponding probability of observing these eigenstates, the second step projects, with high probability, the amplified state into a desired eigenstate, and the last step steers this eigenstate into the target state. Within this scheme, two control algorithms are presented for two classes of quantum systems. As an example, the incoherent control scheme is applied to the control of a hydrogen atom by an external field. The results support the suggestion that projective measurements can serve as an effective control and local controllability information can be used to design control laws for quantum systems. Thus, this scheme establishes a subtle connection between control design and controllability analysis of quantum systems and provides an effective engineering approach in controlling quantum systems with partial controllability information.
Preference towards Control in Risk Taking: Control, No Control, or Randomize?

OpenAIRE

Li, King King

2010-01-01

This paper experimentally investigates preference towards different methods of control in risk taking. Participants are asked to choose between different ways for choosing which numbers to bet on for a gamble. They can choose the numbers themselves (control), let the experimenter choose (no control), or randomize. It is found that in addition to the more conventional preference for control, some participants prefer not to control, or randomization. These preferences are robust as participants...
No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease.

Science.gov (United States)

Kemter, Elisabeth; Sklenak, Stefanie; Rathkolb, Birgit; Hrabě de Angelis, Martin; Wolf, Eckhard; Aigner, Bernhard; Wanke, Ruediger

2014-04-11

Uromodulin (UMOD)-associated kidney disease (UAKD) belongs to the hereditary progressive ER storage diseases caused by maturation defects of mutant UMOD protein. Current treatments of UAKD patients are symptomatic and cannot prevent disease progression. Two in vitro studies reported a positive effect of the chemical chaperone sodium 4-phenylbutyrate (4-PBA) on mutant UMOD maturation. Thus, 4-PBA was suggested as a potential treatment for UAKD. This study evaluated the effects of 4-PBA in two mouse models of UAKD. In contrast to previous in vitro studies, treatment with 4-PBA did not increase HSP70 expression or improve maturation and trafficking of mutant UMOD in vivo. Kidney function of UAKD mice was actually deteriorated by 4-PBA treatment. In transfected tubular epithelial cells, 4-PBA did not improve maturation but increased the expression level of both mutant and wild-type UMOD protein. Activation of NF-κB pathway in thick ascending limb of Henle's loop cells of UAKD mice was detected by increased abundance of RelB and phospho-IκB kinase α/β, an indirect activator of NF-κB. Furthermore, the abundance of NF-κB1 p105/p50, NF-κB2 p100/p52, and TRAF2 was increased in UAKD. NF-κB activation was identified as a novel disease mechanism of UAKD and might be a target for therapeutic intervention.
Insights into dynamics of mobile genetic elements in hyperthermophilic environments from five new Thermococcus plasmids.

Directory of Open Access Journals (Sweden)

Mart Krupovic

Full Text Available Mobilome of hyperthermophilic archaea dwelling in deep-sea hydrothermal vents is poorly characterized. To gain insight into genetic diversity and dynamics of mobile genetic elements in these environments we have sequenced five new plasmids from different Thermococcus strains that have been isolated from geographically remote hydrothermal vents. The plasmids were ascribed to two subfamilies, pTN2-like and pEXT9a-like. Gene content and phylogenetic analyses illuminated a robust connection between pTN2-like plasmids and Pyrococcus abyssi virus 1 (PAV1, with roughly half of the viral genome being composed of genes that have homologues in plasmids. Unexpectedly, pEXT9a-like plasmids were found to be closely related to the previously sequenced plasmid pMETVU01 from Methanocaldococcus vulcanius M7. Our data suggests that the latter observation is most compatible with an unprecedented horizontal transfer of a pEXT9a-like plasmid from Thermococcales to Methanococcales. Gene content analysis revealed that thermococcal plasmids encode Hfq-like proteins and toxin-antitoxin (TA systems of two different families, VapBC and RelBE. Notably, although abundant in archaeal genomes, to our knowledge, TA and hfq-like genes have not been previously found in archaeal plasmids or viruses. Finally, the plasmids described here might prove to be useful in developing new genetic tools for hyperthermophiles.
[NF-κB signaling pathways and the future perspectives of bone disease therapy using selective inhibitors of NF-κB].

Science.gov (United States)

Jimi, Eijiro; Fukushima, Hidefumi

2016-02-01

The transcriptional factor nuclear factor κB(NF-κB)regulates the expression of a wide variety of genes that are involved in immune and inflammatory responses, proliferation, and tumorigenesis. NF-κB consists of five members, such as p65(RelA), RelB, c-Rel, p50/p105(NF-κB1), and p52/p100(NF-κB2). There are two distinct NF-κB activation pathways, termed the classical and alternative NF-κB signaling pathways. Since mice lacking both p50 and p52 subunits developed typical osteopetrosis, due to total lack of osteoclasts, NF-κB is also important osteoclast differentiation. A selective NF-κB inhibitor blocked receptor activator of NF-κB ligand(RANKL)-induced osteoclastogenesis both in vitro and in vivo. Recent findings have shown that inactivation of NF-κB enhances osteoblast differentiation in vitro and bone formation in vivo. NF-κB is constitutively activated in many cancers including oral squamous cell carcinoma(OSCC), and is involved in the invasive characteristics of OSCC. A selective NF-κB inhibitor also prevented jaw bone destruction by OSCC by reduced osteoclast numbers in animal model. Thus the inhibition of NF-κB might useful for the treatment of bone diseases, such as arthritis, osteoporosis, periodontitis, and bone invasion by OSCC by inhibiting bone resorption and by stimulating bone formation.
Active vibration control by robust control techniques

International Nuclear Information System (INIS)

Lohar, F.A.

2001-01-01

This paper studies active vibration control of multi-degree-of-freedom system. The control techniques considered are LTR, H/sup 2/ and H/sup infinite/. The results show that LTR controls the vibration but its respective settling time is higher than that of the other techniques. The control performance of H/sup infinite/ control is similar to that of H/sup 2/ control in the case of it weighting functions. However, H/sup infinite/ control is superior to H/sup 2/ control with respect to robustness, steady state error and settling time. (author)
Density control in ITER: an iterative learning control and robust control approach

Science.gov (United States)

Ravensbergen, T.; de Vries, P. C.; Felici, F.; Blanken, T. C.; Nouailletas, R.; Zabeo, L.

2018-01-01

Plasma density control for next generation tokamaks, such as ITER, is challenging because of multiple reasons. The response of the usual gas valve actuators in future, larger fusion devices, might be too slow for feedback control. Both pellet fuelling and the use of feedforward-based control may help to solve this problem. Also, tight density limits arise during ramp-up, due to operational limits related to divertor detachment and radiative collapses. As the number of shots available for controller tuning will be limited in ITER, in this paper, iterative learning control (ILC) is proposed to determine optimal feedforward actuator inputs based on tracking errors, obtained in previous shots. This control method can take the actuator and density limits into account and can deal with large actuator delays. However, a purely feedforward-based density control may not be sufficient due to the presence of disturbances and shot-to-shot differences. Therefore, robust control synthesis is used to construct a robustly stabilizing feedback controller. In simulations, it is shown that this combined controller strategy is able to achieve good tracking performance in the presence of shot-to-shot differences, tight constraints, and model mismatches.
[Analysis of variation of monoterpene glycosides and polyhydroxy compounds in paeoniae radix alba during preliminary processing].

Science.gov (United States)

Xu, Yuan; Liu, Pei; Yan, Hui; Qian, Da-Wei; Duan, Jin-Ao

2014-05-01

To investigate variation of monoterpene glycosides and polyhydroxy compounds in Paeoniae Radix Alba dried by different processing methods. The crude drugs were processed sequentially as washed, removed the head, tail, fine roots and dried. The samples were divided into eight groups by whether peeled and decocted or not. Each group was dried by 35, 45, 60, 80,100, 120 degrees C, sun-dried and shade-dried. HPLC-PDA method was adopted to determine the content of monoterpene glycosides compounds (paeoniflorin alibiflorin, oxypaeoniflorin and benzoylpaeoniflorin), polyhydroxy compounds (catechin and gallic acid) and benzoic acid. Chromatographic conditions: Phecad C18 column (250 mm x 4.6 mm, 5 microm). A principal component analysis (PCA) method was used subsequently to get data processed. The retained content of seven constituents decreased in those peeled crude drug, and after cooked, monoterpene glycosides and polyhydroxy compounds increased while the benzoic acid decreased. It was believed that rele- vant enzymes were inactivated while being cooked so that drying temperature showed little influence on the biotransformation. Contents of effective ingredients in Paeoniae Radix Alba are influenced by drying processing. The preferable method shows to be that crude drug should be cooked before being peeled and dried. As a matter of processing convtence, it is suggested to be peeled and sliced before being dried.
Konwergencja rachunkowości finansowej i rachunkowości zarządczej w Polsce w świetle badań ankietowych

Directory of Open Access Journals (Sweden)

Przemysław Kabalski

2018-03-01

Full Text Available Celem artykułu jest określenie stopnia konwergencji rachunkowości finansowej i rachunkowości zarządczej w przedsiębiorstwach w Polsce. Do zbadania stopnia konwergencji wykorzystano metodę sondażową z zastosowaniem kwestionariusza ankiety. Okazało się, że poziom konwergencji rachunko- wości w badanych przedsiębiorstwach jest umiarkowany. Badania konwergencji rachunkowości na świecie nie są liczne, a w Polsce ‒ zupełnie wyjątkowe. Z tego względu badanie prezentowane w artykule jest istotne zarówno dla nauki, jak i praktyki rachunkowości. The aim of the article is to determine the level of convergence of financial accounting and management accounting in companies operating in Poland. In order to determine the level of the convergence, the survey method was used. It was found that the level of convergence of accounting in the companies examined is moderate. The number of studies on the convergence of accounting is very limited in the world, and in Poland they are quite unique. For this reason, the research presented in this article is rele- vant for both the science and the practice of accounting.
Presidendi nädal : punk on põhiline!

Index Scriptorium Estoniae

2008-01-01

President Toomas Hendrik Ilvese ja proua Evelin Ilvese suvistest tegemistest. Kadrioru lossi aias 4. juunil 2008 toimunud presidendi kantselei kinnisel peol esines Vaiko Eplik & Eliit. President käis 4. juunil ka Saku suurhallis Bob Dylani kontserdil ja kohtus hiljem muusikuga ning külastas 5. juunil Tallinna vanalinna päevade öökontserti "Tšellorock vanalinnas" Toompea muusikasalongis (esines tšellokvartett C-JAM). Koos abikaasa ja pisitütrega käis riigipea 6. juunil Muhumaal Riigikogu liikmele Imre Sooäärele kuuluva Pädaste mõisa härrastemaja avamisel (esinesid mõisaomanik Imre Sooäär, ooperilauljad Pille Lill, Oliver Kuusik ja poplauljad Maarja-Liis Ilus ning Koit Toome). President võttis sõna ka Rakveres maailma esimesel punklaulupeol 7. juunil. Proua Evelin Ilvesel on 2008. a. juuni algusest Eesti Televisiooni hommikusaates oma isiklikud spordiminutid, kus ta õpetab rahvale rulluisutamise nõkse. Vt. samas: Patroonluse perekonnavõistlus. President T. H. Ilvese ja proua E. Ilvese patroneeritavad asutused ja projektid. Vt. ka foto lk. A9. Ilmunud ka: SL Õhtuleht 13. juuni 2008, lk. 15, pealk.: Bob Dylan saatis Ilvese pikalt (lüh.); Bravo! 26. juuni 2008, nr. 26, lk. 6 (lüh.)
Development the Controller Input Power of Peripheral Interfacing Controller Using Other Micro controller

International Nuclear Information System (INIS)

Syirrazie Che Soh; Harzawardi Hashim; Nor Arymaswati Abdullah; Nur Aira Abdul Rahman; Mohd Ashhar Khalid

2011-01-01

This Controller Input Power of a Peripheral Interfacing Controller was developed using the other micro controller. This paper discuss the switching technique are practiced using proper electronic device to develop the controller, thus enable to control the input power of a PIC in order to expand their interfacing capacity and control. This may allow the PIC could be used to acquire input and control output signal from electronic and electromechanical device and instrument as well as software in wide scale and application. (author)
Researching on YH100 Numerical Control Servo Press Hydraulic Control System and Control Algorithm

Directory of Open Access Journals (Sweden)

Kai LI

2014-09-01

Full Text Available In order to study the numerical control (NC servo press hydraulic control system and its control algorithm. The numerical control servo press performance and control principle of hydraulic control system are analyzed. According to the flow equation of the hydraulic control valve, hydraulic cylinder flow continuity equation and the force balance equation of the hydraulic cylinder with load press, the mathematical model of hydraulic control system is established. And the servo press hydraulic system transfer function is deduced. Introducing the suitable immune particle swarm control algorithm for servo press hydraulic system, and the control system block diagram is established. Immune algorithm is used to optimize new control parameters of the system and adopt the new optimization results to optimize the system simulation. The simulation result shows that the hydraulic system’s transition time controlled by the immune particle swarm algorithm is shorter than traditional ones, and the control performance is obviously improved. Finally it can be concluded that immune particle swarm PID control have these characteristics such as quickness, stability and accuracy. Applying this principle into application, the obtained YH100 numerical control servo press hydraulic control system meets the requirement.
Solid state controller three axes controller

Science.gov (United States)

Bailey, C. L., Jr. (Inventor)

1973-01-01

The reported flight controller features a handle grip which is mounted on a longitudinally extending control element. The handle grip is pivotally mounted on the control element about a pitch axis which is perpendicular to the longitudinal axis through the control element. The pivotal mounting includes a resilient force mounting mechanism which centers the grip relative to the control element. Rotation of the handle grip produces a direct rotation of a transducer element in a transducer which provides an electrical indication of the rotative movement about three mutually perpendicular axes.
Intermittent control: a computational theory of human control.

Science.gov (United States)

Gawthrop, Peter; Loram, Ian; Lakie, Martin; Gollee, Henrik

2011-02-01

The paradigm of continuous control using internal models has advanced understanding of human motor control. However, this paradigm ignores some aspects of human control, including intermittent feedback, serial ballistic control, triggered responses and refractory periods. It is shown that event-driven intermittent control provides a framework to explain the behaviour of the human operator under a wider range of conditions than continuous control. Continuous control is included as a special case, but sampling, system matched hold, an intermittent predictor and an event trigger allow serial open-loop trajectories using intermittent feedback. The implementation here may be described as "continuous observation, intermittent action". Beyond explaining unimodal regulation distributions in common with continuous control, these features naturally explain refractoriness and bimodal stabilisation distributions observed in double stimulus tracking experiments and quiet standing, respectively. Moreover, given that human control systems contain significant time delays, a biological-cybernetic rationale favours intermittent over continuous control: intermittent predictive control is computationally less demanding than continuous predictive control. A standard continuous-time predictive control model of the human operator is used as the underlying design method for an event-driven intermittent controller. It is shown that when event thresholds are small and sampling is regular, the intermittent controller can masquerade as the underlying continuous-time controller and thus, under these conditions, the continuous-time and intermittent controller cannot be distinguished. This explains why the intermittent control hypothesis is consistent with the continuous control hypothesis for certain experimental conditions.
Covariance upperbound controllers for networked control systems

International Nuclear Information System (INIS)

Ko, Sang Ho

2012-01-01

This paper deals with designing covariance upperbound controllers for a linear system that can be used in a networked control environment in which control laws are calculated in a remote controller and transmitted through a shared communication link to the plant. In order to compensate for possible packet losses during the transmission, two different techniques are often employed: the zero-input and the hold-input strategy. These use zero input and the latest control input, respectively, when a packet is lost. For each strategy, we synthesize a class of output covariance upperbound controllers for a given covariance upperbound and a packet loss probability. Existence conditions of the covariance upperbound controller are also provided for each strategy. Through numerical examples, performance of the two strategies is compared in terms of feasibility of implementing the controllers
Control device for the withdrawal of control rod

International Nuclear Information System (INIS)

Ando, Masaki.

1985-01-01

Purpose: To significantly suppress the maximum value of the control-rod worth upon control rod withdrawal. Constitution: At first, a signal for designating the first class is sent from a class-control section to the group-control section. In the group-control section, the peripheral group among the first class is designated by which the withdrawal of the control rods other than the peripheral group is inhibited and the control-rods in the peripheral group are withdrawn one by one. When all of them have been withdrawn, the group-control section designates the central group of the first class. All the control rods of the central group have been withdrawn, then the group-control section designates the peripheral group of the second class. Thereafter, the central group in the second class is designated. The control rods are thus withdrawn in the same manner hereinafter. The maximum value for the control-rod worth can be decreased by such a withdrawing sequence for the control rods. (Horiuchi, T.)
Controllable circuit

DEFF Research Database (Denmark)

2010-01-01

A switch-mode power circuit comprises a controllable element and a control unit. The controllable element is configured to control a current in response to a control signal supplied to the controllable element. The control unit is connected to the controllable element and provides the control...

A Comparative Study on Temperature Control of CSTR using PI Controller, PID Controller and PID (Two Degree of Freedom) Controller

OpenAIRE

Bikash Dey; Lusika Roy

2014-01-01

This paper present three different control strategies based on PI Control, PID control and Two degree of freedom PID control for Continuous Stirred Tank Reactor (CSTR).CSTR which offers a diverse range of application in the field of chemical engineering as well as in the control engineering and is an attractive research area for process control researchers. Our objective is to control the temperature of CSTR in presence of the set point. MATLAB SIMULINK software is used for mo...
A metamorphic controller for plant control system design

Directory of Open Access Journals (Sweden)

Tomasz Klopot

2016-07-01

Full Text Available One of the major problems in the design of industrial control systems is the selection and parameterization of the control algorithm. In practice, the most common solution is the PI (proportional-integral controller, which is simple to implement, but is not always the best control strategy. The use of more advanced controllers may result in a better efficiency of the control system. However, the implementation of advanced control algorithms is more time-consuming and requires specialized knowledge from control engineers. To overcome these problems and to support control engineers at the controller design stage, the paper describes a tool, i.e., a metamorphic controller with extended functionality, for selection and implementation of the most suitable control algorithm. In comparison to existing solutions, the main advantage of the metamorphic controller is its possibility of changing the control algorithm. In turn, the candidate algorithms can be tested through simulations and the total time needed to perform all simulations can be less than a few minutes, which is less than or comparable to the design time in the concurrent design approach. Moreover, the use of well-known tuning procedures, makes the system easy to understand and operate even by inexperienced control engineers. The application was implemented in the real industrial programmable logic controller (PLC and tested with linear and nonlinear virtual plants. The obtained simulation results confirm that the change of the control algorithm allows the control objectives to be achieved at lower costs and in less time.
Control panel for CMC 8080 crate controller

International Nuclear Information System (INIS)

Masayuki Inokuchi

1978-01-01

The main features of Control Panel for CAMAC Crate Controller CMC 8080 are described. The control panel can be directly connected with CRATE CONTROLLER's front panel connector with a 50 lines cable without any changes in CMC 8080 system circuits. (author)
Control rod control device

International Nuclear Information System (INIS)

Seiji, Takehiko; Obara, Kohei; Yanagihashi, Kazumi

1998-01-01

The present invention provides a device suitable for switching of electric motors for driving each of control rods in a nuclear reactor. Namely, in a control rod controlling device, a plurality of previously allotted electric motors connected in parallel as groups, and electric motors of any selected group are driven. In this case, a voltage of not driving predetermined selected electric motors is at first applied. In this state an electric current supplied to the circuit of predetermined electric motors is detected. Whether integration or failure of a power source and the circuit of the predetermined electric motors are normal or not is judged by the detected electric current supplied. After they are judged normal, the electric motors are driven by a regular voltage. With such procedures, whether the selected circuit is normal or not can be accurately confirmed previously. Since the electric motors are not driven just at the selected time, the control rods are not operated erroneously. (I.S.)
Interaction between production control and quality control

NARCIS (Netherlands)

Bij, van der J.D.; Ekert, van J.H.W.

1999-01-01

Describes a qualitative study on interaction between systems for production control and quality control within industrial organisations. Production control and quality control interact in a sense. Good performance for one aspect often influences or frustrates the performance of the other. As far as
A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia.

Science.gov (United States)

Shanmugam, Rajasubramaniam; Gade, Padmaja; Wilson-Weekes, Annique; Sayar, Hamid; Suvannasankha, Attaya; Goswami, Chirayu; Li, Lang; Gupta, Sushil; Cardoso, Angelo A; Baghdadi, Tareq Al; Sargent, Katie J; Cripe, Larry D; Kalvakolanu, Dhananjaya V; Boswell, H Scott

2012-01-15

Death-associated protein kinase 1 (DAPK1), a tumor suppressor, is a rate-limiting effector in an endoplasmic reticulum (ER) stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in several tumors. A mechanistic basis for epigenetic/transcriptional repression of DAPK1 was investigated in certain forms of acute myeloid leukemia (AML) with poor prognosis, which lacked ER stress-induced apoptosis. Heterogeneous primary AMLs were screened to identify a subgroup with Flt3ITD in which repression of DAPK1, among NF-κB-and c-Jun-responsive genes, was studied. RNA interference knockdown studies were carried out in an Flt3ITD(+) cell line, MV-4-11, to establish genetic epistasis in the pathway Flt3ITD-TAK1-DAPK1 repression, and chromatin immunoprecipitations were carried out to identify proximate effector proteins, including TAK1-activated p52NF-κB, at the DAPK1 locus. AMLs characterized by normal karyotype with Flt3ITD were found to have 10- to 100-fold lower DAPK1 transcripts normalized to the expression of c-Jun, a transcriptional activator of DAPK1, as compared with a heterogeneous cytogenetic category. In addition, Meis1, a c-Jun-responsive adverse AML prognostic gene signature was measured as control. These Flt3ITD(+) AMLs overexpress relB, a transcriptional repressor, which forms active heterodimers with p52NF-κB. Chromatin immunoprecipitation assays identified p52NF-κB binding to the DAPK1 promoter together with histone deacetylase 2 (HDAC2) and HDAC6 in the Flt3ITD(+) human AML cell line MV-4-11. Knockdown of p52NF-κB or its upstream regulator, NF-κB-inducing kinase (NIK), de-repressed DAPK1. DAPK1-repressed primary Flt3ITD(+) AMLs had selective nuclear activation of p52NF-κB. Flt3ITD promotes a noncanonical pathway via TAK1 and p52NF-κB to suppress DAPK1 in association with HDACs, which explains DAPK1 repression in Flt3ITD(+) AML. ©2011 AACR.
A non-canonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia (AML)

Science.gov (United States)

Shanmugam, Rajasubramaniam; Sayar, Hamid; Suvannasankha, Attaya; Goswami, Chirayu; Li, Lang; Gupta, Sushil; Cardoso, Angelo A.; Baghdadi, Tareq Al; Sargent, Katie J.; Cripe, Larry D.; Kalvakolanu, Dhananjaya V.; Boswell, H. Scott

2014-01-01

Purpose DAPK1, a tumor suppressor, is a rate-limiting effector in an ER stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in several tumors. A mechanistic basis for epigenetic/transcriptional repression of DAPK1 was investigated in certain forms of AML with poor prognosis, which lacked ER stress-induced apoptosis. Experimental Design Heterogeneous primary AMLs were screened to identify a subgroup with Flt3ITD in which repression of DAPK1, among NF-κB- and c- jun-responsive genes, was studied. RNAi knockdown studies were performed in Flt3ITD+ve cell line, MV-4-11, to establish genetic epistasis in the pathway Flt3ITD-TAK1-DAPK1 repression, and chromatin immunoprecipitations were performed to identify proximate effector proteins, including TAK1-activated p52NF-κB, at the DAPK1 locus. Results AMLs characterized by normal karyotype with Flt3ITD were found to have 10-100-fold lower DAPK1 transcripts normalized to the expression of c-jun, a transcriptional activator of DAPK1, as compared to a heterogeneous cytogenetic category. Meis1, a c-jun-responsive adverse AML prognostic gene signature was also measured as control. These Flt3ITD+ve AMLs over-express relB, a transcriptional repressor, which forms active heterodimers with p52NF-κB. Chromatin immunoprecipitation assays identified p52NF-κB binding to the DAPK1 promoter along with HDAC2 and HDAC6 in the Flt3ITD+ve human AML cell line MV-4-11. Knockdown of p52NF-κB or its upstream regulator, NIK, de-repressed DAPK1. DAPK1-repressed primary Flt3ITD+ve AMLs had selective nuclear activation of p52NF-κB. Conclusions Flt3ITD promotes a non-canonical pathway via TAK1 and p52NF-κB to suppress DAPK1 in association with HDACs, which explains DAPK1 repression in Flt3ITD+ve AML. PMID:22096027
Prototyping qualitative controllers for fuzzy-logic controller design

International Nuclear Information System (INIS)

Bakhtiari, S.; Jabedar-Maralani, P.

1999-05-01

Qualitative controls can be designed for linear and nonlinear models with the same computational complexity. At the same time they show the general form of the proper control. These properties can help ease the design process for quantitative controls. In this paper qualitative controls are used as prototypes for the design of linear or nonlinear, and in particular Sugeno-type fuzzy, controls. The LMS identification method is used to approximate the qualitative control with the nearest fuzzy control. The method is applied to the problem of position control in a permanent magnet synchronous motor; moreover, the performance and the robustness of the two controllers are compared
Emergency Flight Control Using Computer-Controlled Thrust

Science.gov (United States)

Burcham, Frank W., Jr.; Fullerton, C. Gordon; Stewart, James F.; Gilyard, Glenn B.; Conley, Joseph A.

1995-01-01

Propulsion Controlled Aircraft (PCA) systems are digital electronic control systems undergoing development to provide limited maneuvering ability through variations of individual engine thrusts in multiple-engine airplanes. Provide landing capability when control surfaces inoperable. Incorporated on existing and future airplanes that include digital engine controls, digital flight controls, and digital data buses, adding no weight for additional hardware to airplane. Possible to handle total failure of hydraulic system, depending on how surfaces respond to loss of hydraulic pressure, and broken control cables or linkages. Future airplanes incorporate data from Global Positioning System for guidance to any suitable emergency runway in world.
Integrated Control Using the SOFFT Control Structure

Science.gov (United States)

Halyo, Nesim

1996-01-01

The need for integrated/constrained control systems has become clearer as advanced aircraft introduced new coupled subsystems such as new propulsion subsystems with thrust vectoring and new aerodynamic designs. In this study, we develop an integrated control design methodology which accomodates constraints among subsystem variables while using the Stochastic Optimal Feedforward/Feedback Control Technique (SOFFT) thus maintaining all the advantages of the SOFFT approach. The Integrated SOFFT Control methodology uses a centralized feedforward control and a constrained feedback control law. The control thus takes advantage of the known coupling among the subsystems while maintaining the identity of subsystems for validation purposes and the simplicity of the feedback law to understand the system response in complicated nonlinear scenarios. The Variable-Gain Output Feedback Control methodology (including constant gain output feedback) is extended to accommodate equality constraints. A gain computation algorithm is developed. The designer can set the cross-gains between two variables or subsystems to zero or another value and optimize the remaining gains subject to the constraint. An integrated control law is designed for a modified F-15 SMTD aircraft model with coupled airframe and propulsion subsystems using the Integrated SOFFT Control methodology to produce a set of desired flying qualities.
Embedded controllers for local board-control

CERN Document Server

Neufeld, Niko; Mini, Giuseppe; Sannino, Mario; Guzik, Zbigniew; Jacobsson, Richard; Jost, Beat

2005-01-01

The LHCb experiment at CERN has a large number of custom electronic boards performing high-speed data-processing. Like in any large experiment the control and monitoring of these crate-mounted boards must be integrated into the overall control-system. Traditionally this has been done by using buses like VME on the back-plane of the crates. LHCb has chosen to equip every board with an embedded micro-controller and connecting them in a large Local Area Network. The intelligence of these devices allows complex (soft) real-time control and monitoring, required for modern powerful FPGA driven electronics. Moreover each board has its own, isolated control access path, which increases the robustness of the entire system. The system is now in pre-production at several sites and will go into full production during next year. The hardware and software will be discussed and experiences from the R&D and pre-production will be reviewed, with an emphasis on advantages and difficulties of this approach to board-control.
Uniting Control Lyapunov and Control Barrier Functions

NARCIS (Netherlands)

Romdlony, Zakiyullah; Jayawardhana, Bayu

2014-01-01

In this paper, we propose a nonlinear control design for solving the problem of stabilization with guaranteed safety. The design is based on the merging of a Control Lyapunov Function and a Control Barrier Function. The proposed control method allows us to combine the design of a stabilizer based on
EXCHANGE CONTROL AS A FORM STATE FINANCIAL CONTROL

Directory of Open Access Journals (Sweden)

O. Shevchuk

2015-10-01

Full Text Available The article investigates ways to improve the effectiveness of exchange control as an indispensable element of creating systems of financial control. S definition proposed exchange control, interpretation of its functional purpose, the isolation of areas and currency control. Proved that only the presence of effective interconnected and interdependent budget, tax, customs and currency control ensure formation of an effective integrated system of financial control.
Colon cancer controls versus population controls in case-control studies of occupational risk factors

DEFF Research Database (Denmark)

Kaerlev, Linda; Lynge, Elsebeth; Sabroe, Svend

2004-01-01

are interchangeable with the experience for population controls. Patient controls may even be preferable from population controls under certain conditions. In this study we examine if colon cancer patients can serve as surrogates for proper population controls in case-control studies of occupational risk factors...... about occupational, medical and life style conditions. RESULTS: No statistical significant difference for educational level, medical history or smoking status was seen between the two control groups. There was evidence of a higher alcohol intake, less frequent work as a farmer and less exposure...... to pesticides among colon cancer controls. CONCLUSIONS: Use of colon cancer controls may provide valid exposure estimates in studies of many occupational risk factors for cancer, but not for studies on exposure related to farming....
A new controllable damper with neuro controller

International Nuclear Information System (INIS)

Kobayashi, N.; Kobayashi, H.; Saito, O.; Yokoi, R.; Morishita, S.

1993-01-01

A new controllable damper is proposed for suppressing the vibration of the piping system for wide frequency range. Electro-Rheological fluid (ER fluid) is enclosed in the damper casing in place of oil, and the apparent viscosity of ER fluid can be varied by applying electric field strength (E.F.S.), which is controlled by an adaptive neural network controller. The shaking test is conducted about a simplified L-shaped piping model with a prototype controllable damper. The test results show the effectiveness of the presented controllable damper for suppressing very small amplitude vibration of the piping system. Furthermore an application of neural network is discussed to control E.F.S. of the electrode. (author)
PID control with robust disturbance feedback control

DEFF Research Database (Denmark)

Kawai, Fukiko; Vinther, Kasper; Andersen, Palle

2015-01-01

Disturbance Feedback Control (DFC) is a technique, originally proposed by Fuji Electric, for augmenting existing control systems with an extra feedback for attenuation of disturbances and model errors. In this work, we analyze the robustness and performance of a PID-based control system with DFC...... and performance (if such gains exist). Finally, two different simulation case studies are evaluated and compared. Our numerical studies indicate that better performance can be achieved with the proposed method compared with a conservatively tuned PID controller and comparable performance can be achieved when...... compared with an H-infinity controller....
Unfalsified Control; Application to automatic flight control system design

Directory of Open Access Journals (Sweden)

Adrian-Mihail STOICA

2011-09-01

Full Text Available Unfalsified Control Theory has been developed to provide a way for avoiding modeling uncertainties in controller design. It belongs to the class of control methods called Adaptive Supervisory Switching Control, which work by introducing in the control scheme a supervisory unit which chooses, from a set of candidate controllers the one most suited for the current plant. Unfalsified Control works by using a switching logic that dispenses with the need for a-priori knowledge of the dynamic model. At discrete moments of time, using the input/output data recorded up to that point, the supervisory calculates for each candidate controller a performance index, and compares it to a given threshold. Controllers surpassing that threshold are removed from the candidate controller set. This process is called falsification. If the controller in the loop is one such falsified controller it is replaced. In this paper we investigate the suitability of this method for aeronautical control applications. We review the theory behind this control scheme and adapt it to the case of controlling a fighter aircraft. We also provide a case study, where we test this control scheme on a simulated fighter aircraft.
DC motor speed control using fuzzy logic controller

Science.gov (United States)

Ismail, N. L.; Zakaria, K. A.; Nazar, N. S. Moh; Syaripuddin, M.; Mokhtar, A. S. N.; Thanakodi, S.

2018-02-01

The automatic control has played a vital role in the advance of engineering and science. Nowadays in industries, the control of direct current (DC) motor is a common practice thus the implementation of DC motor controller speed is important. The main purpose of motor speed control is to keep the rotation of the motor at the present speed and to drive a system at the demand speed. The main purpose of this project is to control speed of DC Series Wound Motor using Fuzzy Logic Controller (FLC). The expectation of this project is the Fuzzy Logic Controller will get the best performance compared to dc motor without controller in terms of settling time (Ts), rise time (Tr), peak time (Tp) and percent overshoot (%OS).
Dream controller

Science.gov (United States)

Cheng, George Shu-Xing; Mulkey, Steven L; Wang, Qiang; Chow, Andrew J

2013-11-26

A method and apparatus for intelligently controlling continuous process variables. A Dream Controller comprises an Intelligent Engine mechanism and a number of Model-Free Adaptive (MFA) controllers, each of which is suitable to control a process with specific behaviors. The Intelligent Engine can automatically select the appropriate MFA controller and its parameters so that the Dream Controller can be easily used by people with limited control experience and those who do not have the time to commission, tune, and maintain automatic controllers.
Water pressure control device for control rod drive

International Nuclear Information System (INIS)

Sato, Hideyuki.

1981-01-01

Purpose: To minimize the fluctuations in the reactor water level upon occurrence of abnormality by inputting the level signal of the reactor to an arithmetic unit for controlling the pressure of control rod drive water to thereby enable effective reactor level control. Constitution: Signal from a flow rate transmitter is inputted into an arithmetic unit to perform constant flow rate control upon normal operation. While on the other hand, if abnormality occurs such as feedwater pump trips, the arithmetic unit is switched from the constant flow rate control to the reactor water level control. Reactor water level signal is inputted into the arithmetic unit and the control valve is most suitably controlled, whereby water is fed from CST to the reactor by way of control rod drive water system to secure the reactor water level if feedwater to the reactor is interrupted by loss of coolants on the feedwater system. Since this enables to minimize the fluctuations in the reactor water level upon abnormality, the reactor water level can be controlled most suitably by the reactor water level signal. (Moriyama, K.)

Output Control Using Feedforward And Cascade Controllers

Science.gov (United States)

Seraji, Homayoun

1990-01-01

Report presents theoretical study of open-loop control elements in single-input, single-output linear system. Focus on output-control (servomechanism) problem, in which objective is to find control scheme that causes output to track certain command inputs and to reject certain disturbance inputs in steady state. Report closes with brief discussion of characteristics and relative merits of feedforward, cascade, and feedback controllers and combinations thereof.
Comparison Analysis of Model Predictive Controller with Classical PID Controller For pH Control Process

Directory of Open Access Journals (Sweden)

V. Balaji

2016-12-01

Full Text Available pH control plays a important role in any chemical plant and process industries. For the past four decades the classical PID controller has been occupied by the industries. Due to the faster computing technology in the industry demands a tighter advanced control strategy. To fulfill the needs and requirements Model Predictive Control (MPC is the best among all the advanced control algorithms available in the present scenario. The study and analysis has been done for First Order plus Delay Time (FOPDT model controlled by Proportional Integral Derivative (PID and MPC using the Matlab software. This paper explores the capability of the MPC strategy, analyze and compare the control effects with conventional control strategy in pH control. A comparison results between the PID and MPC is plotted using the software. The results clearly show that MPC provide better performance than the classical controller.
Control fast or control smart: When should invading pathogens be controlled?

Directory of Open Access Journals (Sweden)

Robin N Thompson

2018-02-01

Full Text Available The intuitive response to an invading pathogen is to start disease management as rapidly as possible, since this would be expected to minimise the future impacts of disease. However, since more spread data become available as an outbreak unfolds, processes underpinning pathogen transmission can almost always be characterised more precisely later in epidemics. This allows the future progression of any outbreak to be forecast more accurately, and so enables control interventions to be targeted more precisely. There is also the chance that the outbreak might die out without any intervention whatsoever, making prophylactic control unnecessary. Optimal decision-making involves continuously balancing these potential benefits of waiting against the possible costs of further spread. We introduce a generic, extensible data-driven algorithm based on parameter estimation and outbreak simulation for making decisions in real-time concerning when and how to control an invading pathogen. The Control Smart Algorithm (CSA resolves the trade-off between the competing advantages of controlling as soon as possible and controlling later when more information has become available. We show-using a generic mathematical model representing the transmission of a pathogen of agricultural animals or plants through a population of farms or fields-how the CSA allows the timing and level of deployment of vaccination or chemical control to be optimised. In particular, the algorithm outperforms simpler strategies such as intervening when the outbreak size reaches a pre-specified threshold, or controlling when the outbreak has persisted for a threshold length of time. This remains the case even if the simpler methods are fully optimised in advance. Our work highlights the potential benefits of giving careful consideration to the question of when to start disease management during emerging outbreaks, and provides a concrete framework to allow policy-makers to make this decision.
Control fast or control smart: When should invading pathogens be controlled?

Science.gov (United States)

Thompson, Robin N; Gilligan, Christopher A; Cunniffe, Nik J

2018-02-01

The intuitive response to an invading pathogen is to start disease management as rapidly as possible, since this would be expected to minimise the future impacts of disease. However, since more spread data become available as an outbreak unfolds, processes underpinning pathogen transmission can almost always be characterised more precisely later in epidemics. This allows the future progression of any outbreak to be forecast more accurately, and so enables control interventions to be targeted more precisely. There is also the chance that the outbreak might die out without any intervention whatsoever, making prophylactic control unnecessary. Optimal decision-making involves continuously balancing these potential benefits of waiting against the possible costs of further spread. We introduce a generic, extensible data-driven algorithm based on parameter estimation and outbreak simulation for making decisions in real-time concerning when and how to control an invading pathogen. The Control Smart Algorithm (CSA) resolves the trade-off between the competing advantages of controlling as soon as possible and controlling later when more information has become available. We show-using a generic mathematical model representing the transmission of a pathogen of agricultural animals or plants through a population of farms or fields-how the CSA allows the timing and level of deployment of vaccination or chemical control to be optimised. In particular, the algorithm outperforms simpler strategies such as intervening when the outbreak size reaches a pre-specified threshold, or controlling when the outbreak has persisted for a threshold length of time. This remains the case even if the simpler methods are fully optimised in advance. Our work highlights the potential benefits of giving careful consideration to the question of when to start disease management during emerging outbreaks, and provides a concrete framework to allow policy-makers to make this decision.
Model predictive control for a thermostatic controlled system

DEFF Research Database (Denmark)

Shafiei, Seyed Ehsan; Rasmussen, Henrik; Stoustrup, Jakob

2013-01-01

This paper proposes a model predictive control scheme to provide temperature set-points to thermostatic controlled cooling units in refrigeration systems. The control problem is formulated as a convex programming problem to minimize the overall operating cost of the system. The foodstuff temperat......This paper proposes a model predictive control scheme to provide temperature set-points to thermostatic controlled cooling units in refrigeration systems. The control problem is formulated as a convex programming problem to minimize the overall operating cost of the system. The foodstuff...
Chaos control via a simple fractional-order controller

International Nuclear Information System (INIS)

Tavazoei, Mohammad Saleh; Haeri, Mohammad

2008-01-01

In this Letter, we propose a fractional-order controller to stabilize the unstable fixed points of an unstable open-loop system. Also, we show that this controller has strong ability to eliminate chaotic oscillations or reduce them to regular oscillations in the chaotic systems. This controller has simple structure and is designed very easily. To determine the control parameters, one needs only a little knowledge about the plant and therefore, the proposed controller is a suitable choice in the control of uncertain chaotic systems
Use of UPFC device controlled by fuzzy logic controllers for decoupled power flow control

Directory of Open Access Journals (Sweden)

Ivković Sanja

2014-01-01

Full Text Available This paper investigates the possibility of decoupled active and reactive power flow control in a power system using a UPFC device controlled by fuzzy logic controllers. A Brief theoretical review of the operation principles and applications of UPFC devices and design principles of the fuzzy logic controller used are given. A Matlab/Simulink model of the system with UPFC, the fuzzy controller setup, and graphs of the results are presented. Conclusions are drawn regarding the possibility of using this system for decoupled control of the power flow in power systems based on analysis of these graphs.
Digital control programmer for temperature control

International Nuclear Information System (INIS)

Rajore, S.B.; Kumar, S.V.

1993-01-01

This report describes a PC based digital control programmer for controlling and programming temperature of a high vacuum resistance heating furnace and the software developed to control power using PID algorithm. It also describes the amplifier specially developed to suit the input requirement of the non-standard W5 thermocouple and the software and hardware protections introduced in the system. (author). 5 refs., 8 figs., 1 appendix
Plug-and-Play Control – Modifying Control Systems Online

DEFF Research Database (Denmark)

Bendtsen, Jan Dimon; Trangbæk, K; Stoustrup, Jakob

2013-01-01

Often, when new sensor or actuator hardware be- comes available for use in a control system, it is desirable to retain the existing control system and apply the new control capabilities in a gradual fashion rather than decommissioning the entire existing system and replacing it with an altogether...... new control system. However, this requires that the existing controller remains in action, and the new control law component is added to the existing system. This paper formally introduces the concept of Plug-and-Play control and proposes two different methods of introducing new control components...
The Robust Control Mixer Module Method for Control Reconfiguration

DEFF Research Database (Denmark)

Yang, Z.; Blanke, M.

1999-01-01

into a LTI dynamical system, and furthermore multiple dynamical control mixer modules can be employed in our consideration. The H_{\\infty} control theory is used for the analysis and design of the robust control mixer modules. Finally, one practical robot arm system as benchmark is used to test the proposed......The control mixer concept is efficient in improving an ordinary control system into a fault tolerant one, especially for these control systems of which the real-time and on-line redesign of the control laws is very difficult. In order to consider the stability, performance and robustness...... of the reconfigurated system simultaneously, and to deal with a more general controller reconfiguration than the static feedback mechanism by using the control mixer approach, the robust control mixer module method is proposed in this paper. The form of the control mixer module extends from a static gain matrix...
Automobile control technology and traffic control

Energy Technology Data Exchange (ETDEWEB)

Takaba, Sadao [Univ. of Tokyo (Japan)

1988-09-05

In the field of automobile control technology, electronic was first adopted for the electronic fuel control as an answer to the exhaust gas regulations. The operations of the driving system, frame system or the automobile itself which is the combination of the two were optimized by adding sensors, computers, actuators, etc. to alleviate the burden of the driver, offering easier drivability and confortableness. For local driving control, measurement of distance up to obstacle has been practiced using the ultrasonic radar sensor. Research and development of microwave radar sensor have been carried out for years. Automatic driving has been a dream technology, and the study for the technology was started since early times. Remarkable progress was made recently in the navigation system for traffic control in wide area. New automobile traffic information communication and other systems are being developed. Historical description is made on the control and information systems for road transportation, dividing the period into the 1st, 2nd and 3rd generations. 10 references.
Intelligent control schemes applied to Automatic Generation Control

Directory of Open Access Journals (Sweden)

Dingguo Chen

2016-04-01

Full Text Available Integrating ever increasing amount of renewable generating resources to interconnected power systems has created new challenges to the safety and reliability of today‟s power grids and posed new questions to be answered in the power system modeling, analysis and control. Automatic Generation Control (AGC must be extended to be able to accommodate the control of renewable generating assets. In addition, AGC is mandated to operate in accordance with the NERC‟s Control Performance Standard (CPS criteria, which represent a greater flexibility in relaxing the control of generating resources and yet assuring the stability and reliability of interconnected power systems when each balancing authority operates in full compliance. Enhancements in several aspects to the traditional AGC must be made in order to meet the aforementioned challenges. It is the intention of this paper to provide a systematic, mathematical formulation for AGC as a first attempt in the context of meeting the NERC CPS requirements and integrating renewable generating assets, which has not been seen reported in the literature to the best knowledge of the authors. Furthermore, this paper proposes neural network based predictive control schemes for AGC. The proposed controller is capable of handling complicated nonlinear dynamics in comparison with the conventional Proportional Integral (PI controller which is typically most effective to handle linear dynamics. The neural controller is designed in such a way that it has the capability of controlling the system generation in the relaxed manner so the ACE is controlled to a desired range instead of driving it to zero which would otherwise increase the control effort and cost; and most importantly the resulting system control performance meets the NERC CPS requirements and/or the NERC Balancing Authority’s ACE Limit (BAAL compliance requirements whichever are applicable.
Intelligent control-III: fuzzy control system

International Nuclear Information System (INIS)

Nagrial, M.H.

2004-01-01

During the last decade or so, fuzzy logic control (FLC) has emerged as one of the most active and fruitful areas of research and development. The applications include industrial process control to medical diagnostic and financial markets. Many consumer products using this technology are available in the market place. FLC is best suited to complex ill-defined processes that can be controlled by a skilled human operator without much knowledge of their underlying dynamics. This lecture will cover the basic architecture and the design methodology of fuzzy logic controllers. FLC will be strongly based on the concepts of fuzzy set theory, introduced in first lecture. Some practical applications will also be discussed and presented. (author)
Output Power Control of Wind Turbine Generator by Pitch Angle Control using Minimum Variance Control

Science.gov (United States)

Senjyu, Tomonobu; Sakamoto, Ryosei; Urasaki, Naomitsu; Higa, Hiroki; Uezato, Katsumi; Funabashi, Toshihisa

In recent years, there have been problems such as exhaustion of fossil fuels, e. g., coal and oil, and environmental pollution resulting from consumption. Effective utilization of renewable energies such as wind energy is expected instead of the fossil fuel. Wind energy is not constant and windmill output is proportional to the cube of wind speed, which cause the generated power of wind turbine generators (WTGs) to fluctuate. In order to reduce fluctuating components, there is a method to control pitch angle of blades of the windmill. In this paper, output power leveling of wind turbine generator by pitch angle control using an adaptive control is proposed. A self-tuning regulator is used in adaptive control. The control input is determined by the minimum variance control. It is possible to compensate control input to alleviate generating power fluctuation with using proposed controller. The simulation results with using actual detailed model for wind power system show effectiveness of the proposed controller.
Controlling chaotic systems via nonlinear feedback control

International Nuclear Information System (INIS)

Park, Ju H.

2005-01-01

In this article, a new method to control chaotic systems is proposed. Using Lyapunov method, we design a nonlinear feedback controller to make the controlled system be stabilized. A numerical example is given to illuminate the design procedure and advantage of the result derived
Control and optimal control theories with applications

CERN Document Server

Burghes, D N

2004-01-01

This sound introduction to classical and modern control theory concentrates on fundamental concepts. Employing the minimum of mathematical elaboration, it investigates the many applications of control theory to varied and important present-day problems, e.g. economic growth, resource depletion, disease epidemics, exploited population, and rocket trajectories. An original feature is the amount of space devoted to the important and fascinating subject of optimal control. The work is divided into two parts. Part one deals with the control of linear time-continuous systems, using both transfer fun
Implications of the degree of controllability of controlled plants in the sense of LQR optimal control

Science.gov (United States)

Xia, Yaping; Yin, Minghui; Zou, Yun

2018-01-01

In this paper, the relationship between the degree of controllability (DOC) of controlled plants and the corresponding quadratic optimal performance index in LQR control is investigated for the electro-hydraulic synchronising servo control systems and wind turbine systems, respectively. It is shown that for these two types of systems, the higher the DOC of a controlled plant is, the better the quadratic optimal performance index is. It implies that in some LQR controller designs, the measure of the DOC of a controlled plant can be used as an index for the optimisation of adjustable plant parameters, by which the plant can be controlled more effectively.
No Amelioration of Uromodulin Maturation and Trafficking Defect by Sodium 4-Phenylbutyrate in Vivo

Science.gov (United States)

Kemter, Elisabeth; Sklenak, Stefanie; Rathkolb, Birgit; Hrabě de Angelis, Martin; Wolf, Eckhard; Aigner, Bernhard; Wanke, Ruediger

2014-01-01

Uromodulin (UMOD)-associated kidney disease (UAKD) belongs to the hereditary progressive ER storage diseases caused by maturation defects of mutant UMOD protein. Current treatments of UAKD patients are symptomatic and cannot prevent disease progression. Two in vitro studies reported a positive effect of the chemical chaperone sodium 4-phenylbutyrate (4-PBA) on mutant UMOD maturation. Thus, 4-PBA was suggested as a potential treatment for UAKD. This study evaluated the effects of 4-PBA in two mouse models of UAKD. In contrast to previous in vitro studies, treatment with 4-PBA did not increase HSP70 expression or improve maturation and trafficking of mutant UMOD in vivo. Kidney function of UAKD mice was actually deteriorated by 4-PBA treatment. In transfected tubular epithelial cells, 4-PBA did not improve maturation but increased the expression level of both mutant and wild-type UMOD protein. Activation of NF-κB pathway in thick ascending limb of Henle's loop cells of UAKD mice was detected by increased abundance of RelB and phospho-IκB kinase α/β, an indirect activator of NF-κB. Furthermore, the abundance of NF-κB1 p105/p50, NF-κB2 p100/p52, and TRAF2 was increased in UAKD. NF-κB activation was identified as a novel disease mechanism of UAKD and might be a target for therapeutic intervention. PMID:24567330
Homeostatic regulatory role of Pokemon in NF-κB signaling: stimulating both p65 and IκBα expression in human hepatocellular carcinoma cells.

Science.gov (United States)

Zhang, Nan-Nan; Sun, Qin-Sheng; Chen, Zhe; Liu, Feng; Jiang, Yu-Yang

2013-01-01

NF-κB consists of p50, p65 (RelA), p52, c-Rel, and RelB, and among them p65 is a representative protein to investigate the regulation and function of this signaling. NF-κB integrates inflammation and carcinogenesis and regulates the expression of a variety of genes in response to immunity, inflammation, and apoptosis. IκBα acts as an inhibitor of NF-κB through forming an inactive NF-κB/IκBα complex. Pokemon is a ubiquitous transcription factor involved in different signaling pathways, playing a pivotal role in cell proliferation, anti-apoptosis, embryonic development, and maintenance. In this study, we found that p65 and IκBα are both novel regulatory targets of Pokemon. Ectopic expression of Pokemon in immortalized liver cells HL7702 enhanced p65 and IκBα expression, whereas silencing of Pokemon in hepatocellular carcinoma cells QGY7703 reduced cellular p65 levels. ChIP assay and targeted mutagenesis revealed that Pokemon directly binds to the element of -434 to -430 bp in p65 promoter and of -453 to -448 bp in IκBα promoter and stimulates luciferase reporter gene expression. Co-transfection of Pokemon with p65 or IκBα promoter-reporter notably enhanced their promoter activity. These data suggest that Pokemon activates the expression of both p65 and IκBα by sequence-specific binding to their promoters and plays a dual role in regulating NF-κB signaling.
MALT1 Inhibition Is Efficacious in Both Naïve and Ibrutinib-Resistant Chronic Lymphocytic Leukemia.

Science.gov (United States)

Saba, Nakhle S; Wong, Deanna H; Tanios, Georges; Iyer, Jessica R; Lobelle-Rich, Patricia; Dadashian, Eman L; Liu, Delong; Fontan, Lorena; Flemington, Erik K; Nichols, Cydney M; Underbayev, Chingiz; Safah, Hana; Melnick, Ari; Wiestner, Adrian; Herman, Sarah E M

2017-12-15

The clinical efficacy displayed by ibrutinib in chronic lymphocytic leukemia (CLL) has been challenged by the frequent emergence of resistant clones. The ibrutinib target, Bruton's tyrosine kinase (BTK), is essential for B-cell receptor signaling, and most resistant cases carry mutations in BTK or PLCG2 , a downstream effector target of BTK. Recent findings show that MI-2, a small molecule inhibitor of the para-caspase MALT1, is effective in preclinical models of another type of BCR pathway-dependent lymphoma. We therefore studied the activity of MI-2 against CLL and ibrutinib-resistant CLL. Treatment of CLL cells in vitro with MI-2 inhibited MALT1 proteolytic activity reduced BCR and NF-κB signaling, inhibited nuclear translocation of RelB and p50, and decreased Bcl-xL levels. MI-2 selectively induced dose and time-dependent apoptosis in CLL cells, sparing normal B lymphocytes. Furthermore, MI-2 abrogated survival signals provided by stromal cells and BCR cross-linking and was effective against CLL cells harboring features associated with poor outcomes, including 17p deletion and unmutated IGHV Notably, MI-2 was effective against CLL cells collected from patients harboring mutations conferring resistance to ibrutinib. Overall, our findings provide a preclinical rationale for the clinical development of MALT1 inhibitors in CLL, in particular for ibrutinib-resistant forms of this disease. Cancer Res; 77(24); 7038-48. ©2017 AACR . ©2017 American Association for Cancer Research.

Control room philosophy: Principles of control room design and control room work

International Nuclear Information System (INIS)

Skriver, Jan; Ramberg, Jasmine; Allwin, Pernilla

2006-01-01

In order to provide insights for improvement of work in control rooms several factors have to be considered. Knowledge of principles including control room philosophies will guide the recommended improvements. In addition to knowledge about specific principles an advantage for an organization can be an understanding of similarities and policies used in other high risk industry. The report has been developed on the basis of a document analysis of international standards and other guiding documents. (NUREG 0711, ISO 11064, ISO 6385, IEC 60964). In addition to the document analysis which has strived to compare the documents to see similarities in important principals, experience from working with control room design, modifications and evaluations in other high risk industries has pervaded the report. Important principles have been identified which are recommended to be included in a control room philosophy. Many of these are similar to the principles identified in the international standards. An additional principal which is regarded as important is the utilization of Key Performance Indicators (KPI) which can be used as a measure to target preventative means. Further more it is critical that the control room philosophy is easy to access and comprehend for all users. One of the challenges that remain after having developed a control room philosophy is how to utilize it in the daily work situation. It is vital that the document remains as a living document, guiding the continual improvement of the control room in the various life cycle stages
Output controllability of nonlinear systems with bounded control

International Nuclear Information System (INIS)

Garcia, Rafael; D'Attellis, Carlos

1990-01-01

The control problem treated in this paper is the output controllability of a nonlinear system in the form: x = f(x) + g(x)u(t); y = h(x), using bounded controls. The approach to the problem consists of a modification in the system using dynamic feedback in such a way that the input/output behaviour of the closed loop matches the input/output behaviour of a completely output-controllable system with bounded controls. Sufficient conditions are also put forward on the system so that a compact set in the output space may be reached in finite time using uniformally bounded controls, and a result on output regulation in finite time with asymptotic state stabilization is obtained. (Author)
Multimodal Perception and Multicriterion Control of Nested Systems. 1; Coordination of Postural Control and Vehicular Control

Science.gov (United States)

Riccio, Gary E.; McDonald, P. Vernon

1998-01-01

The purpose of this report is to identify the essential characteristics of goal-directed whole-body motion. The report is organized into three major sections (Sections 2, 3, and 4). Section 2 reviews general themes from ecological psychology and control-systems engineering that are relevant to the perception and control of whole-body motion. These themes provide an organizational framework for analyzing the complex and interrelated phenomena that are the defining characteristics of whole-body motion. Section 3 of this report applies the organization framework from the first section to the problem of perception and control of aircraft motion. This is a familiar problem in control-systems engineering and ecological psychology. Section 4 examines an essential but generally neglected aspect of vehicular control: coordination of postural control and vehicular control. To facilitate presentation of this new idea, postural control and its coordination with vehicular control are analyzed in terms of conceptual categories that are familiar in the analysis of vehicular control.
Connecting inventory control and repair shop control : a differentiated control structure for repairable spare parts

NARCIS (Netherlands)

Driessen, M.A.; Rustenburg, W.D.; Houtum, van G.J.J.A.N.; Wiers, V.C.S.

2014-01-01

This paper presents a control structure for integrating decisions on spare parts inventory control and the control of repair shops for maintenance spare parts. A dierentiated control structure is proposed for the various repair shop types recognized in practice. Decisions functions are mapped and
Constrained control allocation for systems with redundant control effectors

OpenAIRE

Bordignon, Kenneth A

1996-01-01

Control allocation is examined for linear time-invariant problems that have more controls than degrees of freedom. The controls are part of a physical system and are subject to limits on their maximum positions. A control allocation scheme commands control deflections in response to some desired output. The ability of a control allocation scheme to produce the desired output without violating the physical position constraints is used to compare allocation schemes. Methods are develop...
Neurofuzzy Control

DEFF Research Database (Denmark)

Jantzen, Jan

1997-01-01

These notes are for a course in fuzzy control and neural networks. By neural networks we more precisely mean neurofuzzy systems rather than pure neural network theory. The notes are an extension to the existing notes on fuzzy control (Jantzen, Fuzzy Control, 1994).......These notes are for a course in fuzzy control and neural networks. By neural networks we more precisely mean neurofuzzy systems rather than pure neural network theory. The notes are an extension to the existing notes on fuzzy control (Jantzen, Fuzzy Control, 1994)....
Resolving Actuator Redundancy - Control Allocation vs. Linear Quadratic Control

OpenAIRE

Härkegård, Ola

2004-01-01

When designing control laws for systems with more inputs than controlled variables, one issue to consider is how to deal with actuator redundancy. Two tools for distributing the control effort among a redundant set of actuators are control allocation and linear quadratic control design. In this paper, we investigate the relationship between these two design tools when a quadratic performance index is used for control allocation. We show that for a particular class of linear systems, they give...
Fuzzy Logic Based Set-Point Weighting Controller Tuning for an Internal Model Control Based PID Controller

Directory of Open Access Journals (Sweden)

Maruthai Suresh

2009-10-01

Full Text Available Controller tuning is the process of adjusting the parameters of the selected controller to achieve optimum response for the controlled process. For many of the control problems, a satisfactory performance is obtained by using PID controllers. One of the main problems with mathematical models of physical systems is that the parameters used in the models cannot be determined with absolute accuracy. The values of the parameters may change with time or various effects. In these cases, conventional controller tuning methods suffer when trying a lot to produce optimum response. In order to overcome these difficulties a fuzzy logic based Set- Point weighting controller tuning method is proposed. The effectiveness of the proposed scheme is analyzed through computer simulation using SIMULINK software and the results are presented. The fuzzy logic based simulation results are compared with Cohen-Coon (CC, Ziegler- Nichols (ZN, Ziegler – Nichols with Set- Point weighting (ZN-SPW, Internal Model Control (IMC and Internal model based PID controller responses (IMC-PID. The effects of process modeling errors and the importance of controller tuning have been brought out using the proposed control scheme.
Control of beam halo-chaos using fuzzy logic controller

International Nuclear Information System (INIS)

Gao Yuan; Yuan Haiying; Tan Guangxing; Luo Wenguang

2012-01-01

Considering the ion beam with initial K-V distribution in the periodic focusing magnetic filed channels (PFCs) as a typical sample, a fuzzy control method for control- ling beam halo-chaos was studied. A fuzzy proportional controller, using output of fuzzy inference as a control factor, was presented for adjusting exterior focusing magnetic field. The stability of controlled system was proved by fuzzy phase plane analysis. The simulation results demonstrate that the chaotic radius of envelope can be controlled to the matched radius via controlling magnetic field. This method was also applied to the multi-particle model. Under the control condition, the beam halos and its regeneration can be eliminated effectively, and that both the compactness and the uniformity of ion beam are improved evidently. Since the exterior magnetic field can be rather easily adjusted by proportional control and the fuzzy logic controller is independent to the mathematical model, this method has adaptive ability and is easily realized in experiment. The research offers a valuable reference for the design of the PFCs in the high- current linear ion accelerators. (authors)
Reactor control device for controlling load of nuclear power plant

International Nuclear Information System (INIS)

Hirota, Tadakuni; Yokoyama, Terukuni; Masuda, Jiro.

1981-01-01

Purpose: To improve the load follow-up capacity of a nuclear reactor by automatically controlling the width of the not-sensing band of a control rod inserting and removing discriminator circuit. Constitution: When load control operations such as automatic load control, automatic frequency control, governor free operation and so forth are conducted, the width of a not sensing band of a control rod inserting and removing discriminator circuit is ao automatically controlled that the not sensing band width may return to ordinary value in a normal operation by avoiding the fast repetition of inserting and removing control rods by increasing the width of the insensing band if the period of a control deviation signal produced due to the variation in the load is quickly repeated and varied in correspondence to the control deviation signal. That is, a circuit for varying the insensing band of the control circuit for driving a control mechanism is provided to reduce the amount of driving the control rods in a load control operation and to reduce the strain of the power distribution of the nuclear reactor, thereby improving the load control capacity. (Yoshihara, H.)
Geodetic Control Points - Multi-State Control Point Database

Data.gov (United States)

NSGIC State | GIS Inventory — The Multi-State Control Point Database (MCPD) is a database of geodetic and mapping control covering Idaho and Montana. The control were submitted by registered land...
Aircraft Landing and Attitude Control Using Dynamic Matrix Control

Directory of Open Access Journals (Sweden)

George Cristian Calugaru

2017-06-01

Full Text Available This paper proposes a method for an efficient control of the aircraft landing and attitude through Dynamic Matrix Control. The idea of MPC structures used in aircraft control has been well established during the last few years, but some aspects require further investigation. With this in mind, the paper proposes structures for aircraft landing and aircraft attitude control by using single DMC controllers for landing and respectively one DMC controller for each of the attitude axis (pitch attitude hold, bank angle hold and heading hold. The model used for analysis of the aircraft landing structure is based on the last phase of landing. Also, the model used to illustrate the attitude control is that of a pitch attitude hold system of a N250-100 aircraft. Simulations are performed for a variety of control and prediction horizons, taking into account the possibility of adding a weighting factor for the control actions. Apart from separate studies on step reference variations, for some use cases, a generic reference trajectory is provided as a control purpose of the system. Results show a better performance of the proposed method in terms of control surface transition and protection of the actuators involved and a better time response in stabilizing the aircraft attitude. Overall, the aspects shown ensure an improved aircraft attitude control and landing stabilization.
Unidirectional Quantum Remote Control:Teleportation of Control-State

Institute of Scientific and Technical Information of China (English)

ZHENG Yi-Zhuang; GU Yong-Jian; WU Gui-Chu; GUO Guang-Can

2003-01-01

We investigate the problem of teleportation of unitary operations by unidirectional control-state telepor-tation and propose a scheme called unidirectional quantum remote control. The scheme is based on the isomorphismbetween operation and state. It allows us to store a unitary operation in a control state, thereby teleportation of theunitary operation can be implemented by unidirectional teleportation of the control-state. We find that the probabilityof success for implementing an arbitrary unitary operation on arbitrary M-qubit state by unidirectional control-stateteleportation is 4-M, and 2M ebits and 4M cbits are consumed in each teleportation.
Control of a mechanical gripper with a fuzzy controller

International Nuclear Information System (INIS)

Alberdi, J.; Barcala, J.M.; Gamero, E.; Navarrete, J.J.

1995-01-01

A fuzzy logic system is used to control a mechanical gripper. System is based in a NLX230 fuzzy micro controller. Control rules are programmed by a 68020 microprocessor in the micro controller memory. Stress and its derived are used as feedback signals in the control. This system can adapt its effort to the mechanical resistance of the object between the fingers. (Author)
Control integral systems; Sistemas integrales de control

Energy Technology Data Exchange (ETDEWEB)

Burgos, Estrella [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

1999-12-31

Almost two third of the electric power generation in Mexico are obtained from hydrocarbons, for that reasons Comision Federal de Electricidad (CFE) dedicated special commitment in modernizing the operation of fossil fuel central stations. In attaining this objective the control systems play a fundamental roll, from them depend a good share of the reliability and the efficiency of the electric power generation process, as well as the extension of the equipment useful life. Since 1984 the Instituto de Investigaciones Electricas (IIE) has been working, upon the request of CFE, on the development of digital control systems. To date it has designed and implemented a logic control system for gas burners, which controls 32 burners of the Unit 4 boiler of the Generation Central of Valle de Mexico and two systems for distributed control for two combined cycle central stations, which are: Dos Bocas, Veracruz Combined cycle central, and Gomez Palacio, Durango combined cycle central. With these two developments the IIE enters the World tendency of implementing distributed control systems for the fossil fuel power central update [Espanol] Casi las dos terceras partes de la generacion electrica en Mexico se obtienen a partir de hidrocarburos, es por eso que la Comision Federal de Electricidad (CFE) puso especial empeno en modernizar la operacion de las centrales termoelectricas de combustibles fosiles. En el logro de este objetivo los sistemas de control desempenan un papel fundamental, de ellos depende una buena parte la confiabilidad y la eficiencia en el proceso de generacion de energia electrica, asi como la prolongacion de la vida util de los equipos. Desde 1984 el Instituto de Investigaciones Electricas (IIE) ha trabajado, a solicitud de la CFE, en el desarrollo de sistemas digitales de control. A la fecha se han disenado e implantado un sistema de control logico de quemadores de gas, el cual controla 32 quemadores de la caldera de la unidad 4 de la central de generacion
Control integral systems; Sistemas integrales de control

Energy Technology Data Exchange (ETDEWEB)

Burgos, Estrella [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

1998-12-31

Almost two third of the electric power generation in Mexico are obtained from hydrocarbons, for that reasons Comision Federal de Electricidad (CFE) dedicated special commitment in modernizing the operation of fossil fuel central stations. In attaining this objective the control systems play a fundamental roll, from them depend a good share of the reliability and the efficiency of the electric power generation process, as well as the extension of the equipment useful life. Since 1984 the Instituto de Investigaciones Electricas (IIE) has been working, upon the request of CFE, on the development of digital control systems. To date it has designed and implemented a logic control system for gas burners, which controls 32 burners of the Unit 4 boiler of the Generation Central of Valle de Mexico and two systems for distributed control for two combined cycle central stations, which are: Dos Bocas, Veracruz Combined cycle central, and Gomez Palacio, Durango combined cycle central. With these two developments the IIE enters the World tendency of implementing distributed control systems for the fossil fuel power central update [Espanol] Casi las dos terceras partes de la generacion electrica en Mexico se obtienen a partir de hidrocarburos, es por eso que la Comision Federal de Electricidad (CFE) puso especial empeno en modernizar la operacion de las centrales termoelectricas de combustibles fosiles. En el logro de este objetivo los sistemas de control desempenan un papel fundamental, de ellos depende una buena parte la confiabilidad y la eficiencia en el proceso de generacion de energia electrica, asi como la prolongacion de la vida util de los equipos. Desde 1984 el Instituto de Investigaciones Electricas (IIE) ha trabajado, a solicitud de la CFE, en el desarrollo de sistemas digitales de control. A la fecha se han disenado e implantado un sistema de control logico de quemadores de gas, el cual controla 32 quemadores de la caldera de la unidad 4 de la central de generacion
Study on Design of Control Module and Fuzzy Control System

International Nuclear Information System (INIS)

Lee, Chang Kyu; Sohn, Chang Ho; Kim, Jung Seon; Kim, Min Kyu

2005-01-01

Performance of control unit is improved by introduction of fuzzy control theory and compensation for input of control unit as FLC(Fuzzy Logic Controller). Here, FLC drives thermal control system by linguistic rule-base. Hence, In case of using compensative PID control unit, it doesn't need to revise or compensate for PID control unit. Consequently, this study shows proof that control system which implements H/W module and then uses fuzzy algorism in this system is stable and has reliable performance
Method for automatic control rod operation using rule-based control

International Nuclear Information System (INIS)

Kinoshita, Mitsuo; Yamada, Naoyuki; Kiguchi, Takashi

1988-01-01

An automatic control rod operation method using rule-based control is proposed. Its features are as follows: (1) a production system to recognize plant events, determine control actions and realize fast inference (fast selection of a suitable production rule), (2) use of the fuzzy control technique to determine quantitative control variables. The method's performance was evaluated by simulation tests on automatic control rod operation at a BWR plant start-up. The results were as follows; (1) The performance which is related to stabilization of controlled variables and time required for reactor start-up, was superior to that of other methods such as PID control and program control methods, (2) the process time to select and interpret the suitable production rule, which was the same as required for event recognition or determination of control action, was short (below 1 s) enough for real time control. The results showed that the method is effective for automatic control rod operation. (author)
Real Time Implementation of a DC Motor Speed Control by Fuzzy Logic Controller and PI Controller Using FPGA

Directory of Open Access Journals (Sweden)

G. Sakthivel

2010-10-01

Full Text Available Fuzzy logic control has met with growing interest in many motor control applications due to its non-linearity, handling features and independence of plant modelling. The hardware implementation of fuzzy logic controller (FLC on FPGA is very important because of the increasing number of fuzzy applications requiring highly parallel and high speed fuzzy processing. Implementation of a fuzzy logic controller and conventional PI controller on an FPGA using VHDL for DC motor speed control is presented in this paper. The proposed scheme is to improve tracking performance of D.C. motor as compared to the conventional (PI control strategy .This paper describes the hardware implementation of two inputs (error and change in error, one output fuzzy logic controller based on PI controller and conventional PI controller using VHDL. Real time implementation FLC and conventional PI controller is made on Spartan-3A DSP FPGA (XC3SD1800A FPGA for the speed control of DC motor. It is observed that fuzzy logic based controllers give better responses than the conventional PI controller for the speed control of dc motor.
Analysis of the Experience of a Virtual Learning Environment Integration Into a Biochemistry Course Offered to Undergraduate Students

Directory of Open Access Journals (Sweden)

M.B. Espíndola

2009-05-01

Full Text Available As Information and Communication Technology (ICT becomes available in educational contexts, it is important that educators experiment different ways to deal with ICT tools in the teaching -learning process at the University basic sciences level. The challenge is to integrate ICT throughout the learning subjects in order to improve the quality of the learning process to students. This paper presents the results of an experience using a Virtual Learning Management System (VLMS, named Constructore, applied in the Biochemistry discipline at the Federal University of Rio de Janeiro (UFRJ for undergraduate medical students. Using Constructore, we developed a learning environment intended for integrating online activities and traditional course content. The course was focused on the integration of energy-yielding metabolism, exploring metabolic adaptations in different physiological or pathological states such as starvation, diabetes and exercise. The course environment was structured with three modules, each of them presenting problem-based exercises to be answered after retrieving rele vant information in original scientific articles. Based on the analysis of a semi-open questionnaire, the results provided evidence that the virtual environment stimulated students to critically read relevant scientific articles and to acquire skills to build and to integrate their knowledge through content association.

Using multinomial and imprecise probability for non-parametric modelling of rainfall in Manizales (Colombia

Directory of Open Access Journals (Sweden)

Ibsen Chivatá Cárdenas

2008-05-01

Full Text Available This article presents a rainfall model constructed by applying non-parametric modelling and imprecise probabilities; these tools were used because there was not enough homogeneous information in the study area. The area’s hydro-logical information regarding rainfall was scarce and existing hydrological time series were not uniform. A distributed extended rainfall model was constructed from so-called probability boxes (p-boxes, multinomial probability distribu-tion and confidence intervals (a friendly algorithm was constructed for non-parametric modelling by combining the last two tools. This model confirmed the high level of uncertainty involved in local rainfall modelling. Uncertainty en-compassed the whole range (domain of probability values thereby showing the severe limitations on information, leading to the conclusion that a detailed estimation of probability would lead to significant error. Nevertheless, rele-vant information was extracted; it was estimated that maximum daily rainfall threshold (70 mm would be surpassed at least once every three years and the magnitude of uncertainty affecting hydrological parameter estimation. This paper’s conclusions may be of interest to non-parametric modellers and decisions-makers as such modelling and imprecise probability represents an alternative for hydrological variable assessment and maybe an obligatory proce-dure in the future. Its potential lies in treating scarce information and represents a robust modelling strategy for non-seasonal stochastic modelling conditions
Enhanced antimicrobial activity and structural transitions of a nanofibrillated cellulose-nisin bio-composite suspension.

Science.gov (United States)

Weishaupt, Ramon; Heuberger, Lukas; Siqueira, Gilberto; Gutt, Beatrice; Zimmermann, Tanja; Maniura-Weber, Katharina; Salentinig, Stefan; Faccio, Greta

2018-05-16

The occurrence of resistance to antibiotics has posed a high demand for novel strategies to fight bacterial infections. Antimicrobial peptides (AMPs) are a promising alternative to con-ventional antibiotics. However, their poor solubility in water and sensitivity to degradation has limited their application. Here we report the design of a smart, pH-responsive antimicro-bial nanobiocomposite material based on the AMP nisin and oxidized nanofibrillated cellulose (TONFC). Morphological transformations of the nano-scale structure of nisin functionalized TONFC fibrils were discovered at pH values between pH 5.8 and 8.0 using small angle X-ray scattering (SAXS). Complementary zeta potential measurements indicate that electrostatic-attractions between the negatively charged TONFC surface and the positively charged nisin molecules are responsible for the integration of nisin. Contrary, shifting the pH level or in-creasing the ionic strength reduce the nisin binding capacity of TONFC. Biological evaluation studies using a bioluminescence-based reporter strain of Bacillus subtilis and a clinically rele-vant strain of Staphylococcus aureus indicated a significantly higher antimicrobial activity of the TONFC-nisin biocomposite compared to the pure nisin against both strains under physio-logical pH and ionic strength conditions. The in-depth characterization of this new class of an-timicrobial bio-composite material based on nanocellulose and nisin, may guide the rational design of sustainable antimicrobial materials.
Theoretical Basics of Teaching Discrete Mathematics

Directory of Open Access Journals (Sweden)

Y. A. Perminov

2012-01-01

Full Text Available The paper deals with the research findings concerning the process of mastering the theoretical basics of discrete mathematics by the students of vocational pedagogic profile. The methodological analysis is based on the subject and functions of the modern discrete mathematics and its role in mathematical modeling and computing. The modern discrete mathematics (i.e. mathematics of the finite type structures plays the important role in modernization of vocational training. It is especially rele- vant to training students for vocational pedagogic qualifications, as in the future they will be responsible for training the middle and the senior level specialists in engineer- ing and technical spheres. Nowadays in different industries, there arise the problems which require for their solving both continual – based on the classical mathematical methods – and discrete modeling. The teaching course of discrete mathematics for the future vocational teachers should be relevant to the target qualification and aimed at mastering the mathematical modeling, systems of computer mathematics and computer technologies. The author emphasizes the fundamental role of mastering the language of algebraic and serial structures, as well as the logical, algorithmic, combinatory schemes dominating in dis- crete mathematics. The guidelines for selecting the content of the course in discrete mathematics are specified. The theoretical findings of the research can be put into practice whilst developing curricula and working programs for bachelors and masters’ training.
Control rods

International Nuclear Information System (INIS)

Maruyama, Hiromi.

1984-01-01

Purpose: To realize effective utilization, cost reduction and weight reduction in neutron absorbing materials. Constitution: Residual amount of neutron absorbing material is averaged between the top end region and other regions of a control rod upon reaching to the control rod working life, by using a single kind of neutron absorbing material and increasing the amount of the neutron absorber material at the top end region of the control rod as compared with that in the other regions. Further, in a case of a control rod having control rod blades such as in a cross-like control rod, the amount of the neutron absorbing material is decreased in the middle portion than in the both end portions of the control rod blade along the transversal direction of the rod, so that the residual amount of the neutron absorbing material is balanced between the central region and both end regions upon reaching the working life of the control rod. (Yoshihara, H.)
Adaptive Extremum Control and Wind Turbine Control

DEFF Research Database (Denmark)

Ma, Xin

1997-01-01

This thesis is divided into two parts, i.e., adaptive extremum control and modelling and control of a wind turbine. The rst part of the thesis deals with the design of adaptive extremum controllers for some processes which have the behaviour that process should have as high e ciency as possible...... in parameters, and thus directly lends itself to parameter estimation and adaptive control. The extremum control law is derived based on static optimization of a performance function. For a process with nonlinearity at output the intermediate signal between the linear part and nonlinear part plays an important....... Firstly, it is assumed that the nonlinear processes can be divided into a dynamic linear part and static nonlinear part. Consequently the processes with input nonlinearity and output nonlinearity are treated separately. With the nonlinearity at the input it is easy to set up a model which is linear...
The neural optimal control hierarchy for motor control

Science.gov (United States)

DeWolf, T.; Eliasmith, C.

2011-10-01

Our empirical, neuroscientific understanding of biological motor systems has been rapidly growing in recent years. However, this understanding has not been systematically mapped to a quantitative characterization of motor control based in control theory. Here, we attempt to bridge this gap by describing the neural optimal control hierarchy (NOCH), which can serve as a foundation for biologically plausible models of neural motor control. The NOCH has been constructed by taking recent control theoretic models of motor control, analyzing the required processes, generating neurally plausible equivalent calculations and mapping them on to the neural structures that have been empirically identified to form the anatomical basis of motor control. We demonstrate the utility of the NOCH by constructing a simple model based on the identified principles and testing it in two ways. First, we perturb specific anatomical elements of the model and compare the resulting motor behavior with clinical data in which the corresponding area of the brain has been damaged. We show that damaging the assigned functions of the basal ganglia and cerebellum can cause the movement deficiencies seen in patients with Huntington's disease and cerebellar lesions. Second, we demonstrate that single spiking neuron data from our model's motor cortical areas explain major features of single-cell responses recorded from the same primate areas. We suggest that together these results show how NOCH-based models can be used to unify a broad range of data relevant to biological motor control in a quantitative, control theoretic framework.
Success Stories in Control: Nonlinear Dynamic Inversion Control

Science.gov (United States)

Bosworth, John T.

2010-01-01

NASA plays an important role in advancing the state of the art in flight control systems. In the case of Nonlinear Dynamic Inversion (NDI) NASA supported initial implementation of the theory in an aircraft and demonstration in a space vehicle. Dr. Dale Enns of Honeywell Aerospace Advanced Technology performed this work in cooperation with NASA and under NASA contract. Honeywell and Lockheed Martin were subsequently contracted by AFRL to create "Design Guidelines for Multivariable Control Theory". This foundational work directly contributed to the advancement of the technology and the credibility of the control law as a design option. As a result Honeywell collaborated with Lockheed Martin to produce a Nonlinear Dynamic Inversion controller for the X-35 and subsequently Lockheed Martin did the same for the production Lockheed Martin F-35 vehicle. The theory behind NDI is to use a systematic generalized approach to controlling a vehicle. Using general aircraft nonlinear equations of motion and onboard aerodynamic, mass properties, and engine models specific to the vehicle, a relationship between control effectors and desired aircraft motion can be formulated. Using this formulation a control combination is used that provides a predictable response to commanded motion. Control loops around this formulation shape the response as desired and provide robustness to modeling errors. Once the control law is designed it can be used on a similar class of vehicle with only an update to the vehicle specific onboard models.
Fractional order PID controller for load frequency control

International Nuclear Information System (INIS)

Sondhi, Swati; Hote, Yogesh V.

2014-01-01

Highlights: • The manuscript shows the design of FOPID controller for the load frequency control. • Performance of FOPID is given for non-reheated, reheated and hydro turbine. • Performance of FOPID is compared to IMC-PID and reduced order IMC-PID design scheme. • Performance of FOPID is better than the existing techniques. - Abstract: Load frequency control (LFC) plays a very important role in providing quality power both in the case of isolated as well as interconnected power systems. In order to maintain good quality power supply, the LFC should possess robustness toward the parametric uncertainty of the system and good disturbance rejection capability. The fractional order controller has the properties such as, eliminating steady state error, robustness toward plant gain variations and also good disturbance rejection. This makes the fractional order PID (FOPID) controller quite suitable for the LFC. Therefore, in this paper a FOPID is designed for single area LFC for all three types of turbines i.e., non-reheated, reheated and hydro turbines. It is observed that the FOPID controller shows better robustness toward ±50% parametric uncertainty and disturbance rejection capability than the existing techniques. Finally, the optimization of controller parameters and robustness evaluation of the control technique is done on the basis of the integral error criterion
Structural controllability and controlling centrality of temporal networks.

Science.gov (United States)

Pan, Yujian; Li, Xiang

2014-01-01

Temporal networks are such networks where nodes and interactions may appear and disappear at various time scales. With the evidence of ubiquity of temporal networks in our economy, nature and society, it's urgent and significant to focus on its structural controllability as well as the corresponding characteristics, which nowadays is still an untouched topic. We develop graphic tools to study the structural controllability as well as its characteristics, identifying the intrinsic mechanism of the ability of individuals in controlling a dynamic and large-scale temporal network. Classifying temporal trees of a temporal network into different types, we give (both upper and lower) analytical bounds of the controlling centrality, which are verified by numerical simulations of both artificial and empirical temporal networks. We find that the positive relationship between aggregated degree and controlling centrality as well as the scale-free distribution of node's controlling centrality are virtually independent of the time scale and types of datasets, meaning the inherent robustness and heterogeneity of the controlling centrality of nodes within temporal networks.
Kinematics and Dynamics of Motion Control Based on Acceleration Control

Science.gov (United States)

Ohishi, Kiyoshi; Ohba, Yuzuru; Katsura, Seiichiro

The first IEEE International Workshop on Advanced Motion Control was held in 1990 pointed out the importance of physical interpretation of motion control. The software servoing technology is now common in machine tools, robotics, and mechatronics. It has been intensively developed for the numerical control (NC) machines. Recently, motion control in unknown environment will be more and more important. Conventional motion control is not always suitable due to the lack of adaptive capability to the environment. A more sophisticated ability in motion control is necessary for compliant contact with environment. Acceleration control is the key technology of motion control in unknown environment. The acceleration control can make a motion system to be a zero control stiffness system without losing the robustness. Furthermore, a realization of multi-degree-of-freedom motion is necessary for future human assistance. A human assistant motion will require various control stiffness corresponding to the task. The review paper focuses on the modal coordinate system to integrate the various control stiffness in the virtual axes. A bilateral teleoperation is a good candidate to consider the future human assistant motion and integration of decentralized systems. Thus the paper reviews and discusses the bilateral teleoperation from the control stiffness and the modal control design points of view.
Generalized Predictive Control and Neural Generalized Predictive Control

Directory of Open Access Journals (Sweden)

Sadhana CHIDRAWAR

2008-12-01

Full Text Available As Model Predictive Control (MPC relies on the predictive Control using a multilayer feed forward network as the plants linear model is presented. In using Newton-Raphson as the optimization algorithm, the number of iterations needed for convergence is significantly reduced from other techniques. This paper presents a detailed derivation of the Generalized Predictive Control and Neural Generalized Predictive Control with Newton-Raphson as minimization algorithm. Taking three separate systems, performances of the system has been tested. Simulation results show the effect of neural network on Generalized Predictive Control. The performance comparison of this three system configurations has been given in terms of ISE and IAE.
Power control device

International Nuclear Information System (INIS)

Fukawa, Naohiro.

1982-01-01

Purpose: To alleviate the load of an operator by automatically operating the main controller, the speed controller, etc. of a recirculation control system and safely operating them without erroneous operation for long period of time, thereby improving the efficiency of a plant. Constitution: An electric type hydraulic control device controls loads of a turbine and a generator and outputs a control signal also to the main controller of a recirculation flow rate control system. At this time, the main controller is set at an automatic position, and the speed controller receives a recirculation pump speed signal from the main controller at the automatic position. The speed controller outputs a pump speed control signal to the recirculation pump system, and a reactor generates a power corresponding thereto. When the power control is automatically performed by the recirculation flow rate control, an operator sets a rate of change of the recirculation pump speed and the rate of change of the mean power range monitor at a change rate setting unit. Therefore, the control of the recirculation flow rate under the power control can be substantially entirely automated. (Yoshigara, H.)
Digital linear control theory for automatic stepsize control

NARCIS (Netherlands)

Verhoeven, A.; Beelen, T.G.J.; Hautus, M.L.J.; Maten, ter E.J.W.; Anile, A.M.; Ali, G.; Mascali, G.

2006-01-01

In transient analysis of electrical circuits the solution is computed by means of numerical integration methods. Adaptive stepsize control is used to control the local errors of the numerical solution. For optimization purposes smoother stepsize controllers can ensure that the errors and stepsizes
A Lyapunov theory based UPFC controller for power flow control

Energy Technology Data Exchange (ETDEWEB)

Zangeneh, Ali; Kazemi, Ahad; Hajatipour, Majid; Jadid, Shahram [Center of Excellence for Power Systems Automation and Operation, Iran University of Science and Technology, Tehran (Iran)

2009-09-15

Unified power flow controller (UPFC) is the most comprehensive multivariable device among the FACTS controllers. Capability of power flow control is the most important responsibility of UPFC. According to high importance of power flow control in transmission lines, the proper controller should be robust against uncertainty and disturbance and also have suitable settling time. For this purpose, a new controller is designed based on the Lyapunov theory and its stability is also evaluated. The Main goal of this paper is to design a controller which enables a power system to track reference signals precisely and to be robust in the presence of uncertainty of system parameters and disturbances. The performance of the proposed controller is simulated on a two bus test system and compared with a conventional PI controller. The simulation results show the power and accuracy of the proposed controller. (author)
Control rod drives

International Nuclear Information System (INIS)

Hayakawa, Hiroyasu.

1979-01-01

Purpose: To enable rapid control in a simple circuit by providing a motor control device having an electric capacity capable of simultaneously driving all of the control rods rapidly only in the inserting direction as well as a motor controlling device capable of fine control for the insertion and extraction at usual operation. Constitution: The control rod drives comprise a first motor control device capable of finely controlling the control rods both in inserting and extracting directions, a second motor control device capable of rapidly driving the control rods only in the inserting direction, and a first motor switching circuit and a second motor switching circuit switched by switches. Upon issue of a rapid insertion instruction for the control rods, the second motor switching circuit is closed by the switch and the second motor control circuit and driving motors are connected. Thus, each of the control rod driving motors is driven at a high speed in the inserting direction to rapidly insert all of the control rods. (Yoshino, Y.)
Indirect control and power in mutual control structures

NARCIS (Netherlands)

Karos, D.; Peters, H.J.M.

2013-01-01

In a mutual control structure agents exercise control over each other. Typical examples occur in the area of corporate governance: firms and investment companies exercise mutual control, in particular by owning each others’ stocks. In this paper we formulate a general model for such situations.
Reactor control device

International Nuclear Information System (INIS)

Fukami, Haruo; Morimoto, Yoshinori.

1981-01-01

Purpose: To operate a reactor always with safety operation while eliminating the danger of tripping. Constitution: In a reactor control device adapted to detect the process variants of a reactor, control a control rod drive controlling system based on the detected signal to thereby control the driving the control rods, control the reactor power and control the electric power generated from an electric generator by the output from the reactor, detection means is provided for the detection of the electric power from said electric generator, and a compensation device is provided for outputting control rod driving compensation signals to the control rod driving controlling system in accordance with the amount of variation in the detected value. (Seki, T.)
Bangbang controller design and implementation for EAST vertical instability control

Energy Technology Data Exchange (ETDEWEB)

Wang, Yuehang, E-mail: wagn8901@mail.ustc.edu.cn [University of Science and Technology of China, Hefei (China); Xiao, Bingjia, E-mail: bjxiao@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); University of Science and Technology of China, Hefei (China); Liu, Lei, E-mail: liulei@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Yuan, Qiping, E-mail: qpyuan@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China)

2016-11-15

Highlights: • The linearized plasma vertical response model is designed and analysed. • The Bangbang controller for EAST vertical displacement is designed. • The Bangbang controller is optimized for time delay of control system. • We investigate efficacy of Bangbang controller with simulations. • Performance of the controller is roughly given by experiments. - Abstract: In the EAST 2014 campaign, a new internal coil (IC) power supply was used in order to enhance the control over the plasma’s vertical instabilities. The IC power supply now allows for current and voltage working modes with much higher peak voltages and currents and faster response time. In comparison the previous power supply only allowed for the current mode. A Bangbang and PID composite controller has been designed for the voltage mode based on optimal control theory and the RZIP rigid plasma response model. This paper will demonstrate that faster and enhanced controllability are realized with the combination of Bangbang and PID controller. For the large z position drift, the Bangbang controller will export the maximum voltage to achieve much faster power supply response and slow the vertical displacement events (VDEs). The PID controller is used for the small z drifts which will finally stabilize the VDEs with minimum z position oscillation. Furthermore, to evaluate the time latency of this control system and power supply, the stability and performance of the closed loop were simulated and analysed. This controller was finally implementation and test on EAST using the Quasi-snowflake shape which achieved growth rates of 500 s{sup −1}. This paper shows that the new power supply using the bangbang + PID controller can significantly enhance the control over vertical instabilities.
Tracking Control Based on Control Allocation with an Innovative Control Effector Aircraft Application

Directory of Open Access Journals (Sweden)

Chaoyang Dong

2016-01-01

Full Text Available This paper proposes a control allocation method for the tracking control problem of a class of morphing aircraft with special actuators which are different from the conventional actuation surfaces. This design of actuators can bring about some potential advantages to the flight vehicles; however, due to the integral constraints, the desired control cannot be performed accurately; therefore, it leads to undesirable tracking errors, so influencing the performance of the system. Because the system could be control allocated, based on the designed cost function that describes the tracking errors, the cuckoo search algorithm (CSA is introduced to search for the optimum solution within the calculated actuator execution commands that are equivalent to the desired commands. Several improvement measures are proposed for boosting the efficiency of the CSA and ensuring reasonable solutions. Simulation results show that the proposed control allocation method is necessary and effective, and the improvement measures are helpful in obtaining the optimum solution.
Hydraulic pressure control unit for control rod drive

International Nuclear Information System (INIS)

Watabe, Yukio.

1990-01-01

The pressure invention concerns a hydraulic pressure control unit for control rod drives in BWR type reactors. The space above a floating piston possessed by an accumulator and the housing of control rod drives are connected by means of a pipeline. The pipeline has a scram valve which is opened upon occurrence of reactor scram. A pump is disposed between the accumulator and the scram valve for communicating a discharge port to apply a high pressure water to the accumulator. According to the present invention, a control unit is disposed between the scram valve and the housing of the control rod drives in the hydraulic pressure control unit for maintaining the cross sectional area of the flow channel of the pipeline to a usual size when the pressure in a pressure vessel is under a rated operation pressure, while limiting the cross sectional area of the flow channel when the pressure is lower than that in the rated operation. Thus, whole insertion of the control rod substantially at a constant speed is enabled irrespective of the level of the pressure in the pressure vessel. (I.S.)

Control Areas

Data.gov (United States)

Department of Homeland Security — This feature class represents electric power Control Areas. Control Areas, also known as Balancing Authority Areas, are controlled by Balancing Authorities, who are...
Active control versus recursive backstepping control of a chaotic ...

African Journals Online (AJOL)

In this paper active controllers and recursive backstepping controllers are designed for a third order chaotic system. The performances of these controllers in the control of the dynamics of the chaotic system are investigated numerically and are found to be effective. Comparison of their transient performances show that the ...
Tuning method for multi-variable control system with PID controllers

International Nuclear Information System (INIS)

Fujiwara, Toshitaka

1983-01-01

Control systems, including thermal and nuclear power plants, generally and mainly use PID controllers consisting of proportional, integral and differential actions. These systems consist of multiple control loops which interfere with each other. Therefore, it is present status that the fine control of the system is carried out by the trial and error method because the adjusting procedure for a single control loop cannot be applied to a multi-loop system in most cases. In this report, a method to effectively adjust PID controller parameters in a short time in a control system which consists of multi-loops that interfere with each other. This method makes adjustment by using the control area as the evaluation function, which is the time-dependent integration of control deviation, the input to the PID controllers. In other words, the evaluation function is provided for each control result for every parameter (gain constant, reset rate, and differentiation time), and all parameters are simultaneously changed in the direction of minimizing the values of these evaluation functions. In the report, the principle of tuning method, the evaluation function for each of three parameters, and the adjusting system configuration for separately using for actual plant tuning and for control system design are described. It also shows the examples of application to the actual tuning of the control system for a thermal power plant and to a control system design. (Wakatsuki, Y.)
Cascade control of superheated steam temperature with neuro-PID controller.

Science.gov (United States)

Zhang, Jianhua; Zhang, Fenfang; Ren, Mifeng; Hou, Guolian; Fang, Fang

2012-11-01

In this paper, an improved cascade control methodology for superheated processes is developed, in which the primary PID controller is implemented by neural networks trained by minimizing error entropy criterion. The entropy of the tracking error can be estimated recursively by utilizing receding horizon window technique. The measurable disturbances in superheated processes are input to the neuro-PID controller besides the sequences of tracking error in outer loop control system, hence, feedback control is combined with feedforward control in the proposed neuro-PID controller. The convergent condition of the neural networks is analyzed. The implementation procedures of the proposed cascade control approach are summarized. Compared with the neuro-PID controller using minimizing squared error criterion, the proposed neuro-PID controller using minimizing error entropy criterion may decrease fluctuations of the superheated steam temperature. A simulation example shows the advantages of the proposed method. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.
46 CFR 111.70-3 - Motor controllers and motor-control centers.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Motor controllers and motor-control centers. 111.70-3... ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Motor Circuits, Controllers, and Protection § 111.70-3 Motor controllers and motor-control centers. (a) General. The enclosure for each motor controller or motor-control...
Temperature uniformity control in RTP using multivariable adaptive control

Energy Technology Data Exchange (ETDEWEB)

Morales, S.; Dahhou, B.; Dilhac, J.M. [Centre National de la Recherche Scientifique (CNRS), 31 - Toulouse (France); Morales, S.

1995-12-31

In Rapid Thermal Processing (RTP) control of the wafer temperature during all processing to get good trajectory following, together with spatial temperature uniformity, is essential. It is well know as RTP process is nonlinear, classical control laws are not very efficient. In this work, the authors aim at studying the applicability of MIMO (Multiple Inputs Multiple Outputs) adaptive techniques to solve the temperature control problems in RTP. A multivariable linear discrete time CARIMA (Controlled Auto Regressive Integrating Moving Average) model of the highly non-linear process is identified on-line using a robust identification technique. The identified model is used to compute an infinite time LQ (Linear Quadratic) based control law, with a partial state reference model. This reference model smooths the original setpoint sequence, and at the same time gives a tracking capability to the LQ control law. After an experimental open-loop investigation, the results of the application of the adaptive control law are presented. Finally, some comments on the future difficulties and developments of the application of adaptive control in RTP are given. (author) 13 refs.
Design of controller for control rod of research reactors

International Nuclear Information System (INIS)

Abou-Zaid, R.M.F.M

2008-01-01

Designing and testing digital control system for any nuclear research reactor can be costly and time consuming. In this thesis, a rapid, low-cost proto typing and testing procedure for digital controller design is proposed using the concept of Hardware-In-The-Loop (HIL). Some of the control loop components are real hardware components and the others are simulated. First, the whole system is modeled and tested by Real-Time Simulation (RTS) using conventional simulation techniques such as MATLAB / SIMULINK. Second the Hardware-in-the-loop simulation is tested using Real-Time Windows Target in MATLAB and Visual C ++ . The control parts are included as hardware components which are the reactor control rod and its drivers. Three kinds of controllers are studied, Proportional-Derivative (PD), Proportional-Integral-Derivative (PID) and Fuzzy controller. An experimental setup for the hardware used in HIL concept for the control of the nuclear research reactor has been realized. Experimental results are obtained and compared with the simulation results. The experimental results indicate the validation of HIL method in this domain.
SODR Memory Control Buffer Control ASIC

Science.gov (United States)

Hodson, Robert F.

1994-01-01

The Spacecraft Optical Disk Recorder (SODR) is a state of the art mass storage system for future NASA missions requiring high transmission rates and a large capacity storage system. This report covers the design and development of an SODR memory buffer control applications specific integrated circuit (ASIC). The memory buffer control ASIC has two primary functions: (1) buffering data to prevent loss of data during disk access times, (2) converting data formats from a high performance parallel interface format to a small computer systems interface format. Ten 144 p in, 50 MHz CMOS ASIC's were designed, fabricated and tested to implement the memory buffer control function.
Observer-Based Robust Control for Hydraulic Velocity Control System

Directory of Open Access Journals (Sweden)

Wei Shen

2013-01-01

Full Text Available This paper investigates the problems of robust stabilization and robust control for the secondary component speed control system with parameters uncertainty and load disturbance. The aim is to enhance the control performance of hydraulic system based on Common Pressure Rail (CPR. Firstly, a mathematical model is presented to describe the hydraulic control system. Then a novel observer is proposed, and an observed-based control strategy is designed such that the closed-loop system is asymptotically stable and satisfies the disturbance attenuation level. The condition for the existence of the developed controller can by efficiently solved by using the MATLAB software. Finally, simulation results are provided to demonstrate the effectiveness of the proposed method.
Improved fuzzy PID controller design using predictive functional control structure.

Science.gov (United States)

Wang, Yuzhong; Jin, Qibing; Zhang, Ridong

2017-11-01

In conventional PID scheme, the ensemble control performance may be unsatisfactory due to limited degrees of freedom under various kinds of uncertainty. To overcome this disadvantage, a novel PID control method that inherits the advantages of fuzzy PID control and the predictive functional control (PFC) is presented and further verified on the temperature model of a coke furnace. Based on the framework of PFC, the prediction of the future process behavior is first obtained using the current process input signal. Then, the fuzzy PID control based on the multi-step prediction is introduced to acquire the optimal control law. Finally, the case study on a temperature model of a coke furnace shows the effectiveness of the fuzzy PID control scheme when compared with conventional PID control and fuzzy self-adaptive PID control. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.
Hardware design of a microcomputer controlled diagnostic vacuum controller

International Nuclear Information System (INIS)

Marsala, R.J.

1983-01-01

The TFTR diagnostic vacuum controller (DVC) has been designed and built to control and monitor the pumps, valves and gauges which comprise a diagnostic vacuum system. The DVC is a microcomputer based self-contained controller with battery backup which may be controlled manually from front panel controls or remotely via CICADA. The DVC implements all pump and valve sequencing and provides protection against incorrect operation. There are presently two versions of the DVC operating on TFTR and a third version being used on the S-1 machine
Fuzzy control. Fundamentals, stability and design of fuzzy controllers

Energy Technology Data Exchange (ETDEWEB)

Michels, K. [Fichtner GmbH und Co. KG, Stuttgart (Germany); Klawonn, F. [Fachhochschule Braunschweig/Wolfenbuettel (Germany). Fachbereich Informatik; Kruse, R. [Magdeburg Univ. (Germany). Fakultaet Informatik, Abt. Wiss.- und Sprachverarbeitung; Nuernberger, A. (eds.) [California Univ., Berkeley, CA (United States). Computer Science Division

2006-07-01

The book provides a critical discussion of fuzzy controllers from the perspective of classical control theory. Special emphases are placed on topics that are of importance for industrial applications, like (self-) tuning of fuzzy controllers, optimisation and stability analysis. The book is written as a textbook for graduate students as well as a comprehensive reference book about fuzzy control for researchers and application engineers. Starting with a detailed introduction to fuzzy systems and control theory the reader is guided to up-to-date research results. (orig.)
Velocity control of a secondary controlled closed-loop hydrostatic transmission system using an adaptive fuzzy sliding mode controller

Energy Technology Data Exchange (ETDEWEB)

Do, Hoang Thinh; Ahn, Kyoung Kwan [University of Ulsan, Ulsan (Korea, Republic of)

2013-03-15

A secondary-controlled hydrostatic transmission system (SC-HST), which considered being an energy-saving system, can recuperate most of the lost vehicle kinetic energy in decelerating and braking time and it shows advantage in fuel economy improvement of vehicle. Almost secondary control units (SCU) in SC-HST inherently contain nonlinear characteristics such as dead-zone input. Therefore, it is difficult to obtain precise position or velocity control by conventional linear controllers. This problem limits the application of SC-HST in industry and mobile vehicle. This paper gives a description of SC-HST and proposes an adaptive fuzzy sliding mode controller (AFSMC) for velocity control of SCU. Experiments were carried out in the condition of disturbance load by using both the proposed controller and PID controller for the comparison and evaluation of the effectiveness of the proposed controller. The experimental results showed that the proposed controller was excellent from the standpoints of performance and stability for the velocity control of SC-HST.
COPD - control drugs

Science.gov (United States)

Chronic obstructive pulmonary disease - control drugs; Bronchodilators - COPD - control drugs; Beta agonist inhaler - COPD - control drugs; Anticholinergic inhaler - COPD - control drugs; Long-acting inhaler - COPD - control drugs; ...
Real-time control of Tokamak plasmas: from control of physics to physics-based control

International Nuclear Information System (INIS)

Felici, F. A. A.

2011-11-01

Stable, high-performance operation of a tokamak requires several plasma control problems to be handled simultaneously. Moreover, the complex physics which governs the tokamak plasma evolution must be studied and understood to make correct choices in controller design. In this thesis, the two subjects have been merged, using control solutions as experimental tool for physics studies, and using physics knowledge for developing new advanced control solutions. The TCV tokamak at CRPP-EPFL is ideally placed to explore issues at the interface between plasma physics and plasma control, by combining a digital realtime control system with a flexible and powerful set of actuators, in particular the electron cyclotron heating and current drive system (ECRH/ECCD). This experimental platform has been used to develop and test new control strategies for three plasma physics instabilities: sawtooth, edge localized mode (ELM) and neoclassical tearing mode (NTM). The period of the sawtooth crash, a periodic MHD instability in the core of a tokamak plasma, can be varied by localized deposition of ECRH/ECCD near the q = 1 surface (q: safety factor). A sawtooth pacing controller was developed which is able to control the time of appearance of the next sawtooth crash. Each individual sawtooth period can be controlled in real-time. A similar scheme is applied to H-mode plasmas with type-I ELMs, where it is shown that pacing regularizes the ELM period. The regular, reproducible and therefore predictable sawtooth crashes have been used to study the relationship between sawteeth and NTMs. Postcrash MHD activity can provide the ‘seed’ island for an NTM, which then grows under its neoclassical bootstrap drive. The seeding of 3/2 NTMs by long sawtooth crashes can be avoided by preemptive, crash-synchronized EC power injection pulses at the q = 3/2 rational surface location. NTM stabilization experiments in which the ECRH deposition location is moved in real-time with steerable mirrors have
Arbitrating Control of Control and Display Units

Science.gov (United States)

Sugden, Paul C.

2007-01-01

The ARINC 739 Switch is a computer program that arbitrates control of two multi-function control and display units (MCDUs) between (1) a commercial flight-management computer (FMC) and (2) NASA software used in research on transport aircraft. (MCDUs are the primary interfaces between pilots and FMCs on many commercial aircraft.) This program was recently redesigned into a software library that can be embedded in research application programs. As part of the redesign, this software was combined with software for creating custom pages of information to be displayed on a CDU. This software commands independent switching of the left (pilot s) and right (copilot s) MCDUs. For example, a custom CDU page can control the left CDU while the FMC controls the right CDU. The software uses menu keys to switch control of the CDU between the FMC or a custom CDU page. The software provides an interface that enables custom CDU pages to insert keystrokes into the FMC s CDU input interface. This feature allows the custom CDU pages to manipulate the FMC as if it were a pilot.
Mosquito Control

Science.gov (United States)

... Labs and Research Centers Contact Us Share Mosquito Control About Mosquitoes General Information Life Cycle Information from ... Repellent that is Right for You DEET Mosquito Control Methods Success in mosquito control: an integrated approach ...
Control room, emergency control system and local control panels in nuclear power plants

International Nuclear Information System (INIS)

1988-01-01

The requirements on planning and construction of control boards including ergonomic-technical designing are specified in this rule. The specifications put the requirements on the design of place, process and environment of work, which are mentioned in the sections 90 and 91 of the labor-management relations act, into more concrete terms for the safety-relevant control panels as work places in a nuclear power station. The work places at control panels are not considered as video workstations in the sense of the 'Safety Rules for Video Workstations in the Office Sector' published by the General Association of the Industrial Trade Associations. The requirements are based on the operation and information technology realized at present in control panels of stationary nuclear power plants. (orig./HP) [de
Multicopter control with Navio using REX control system

Science.gov (United States)

Golembiovsky, Matej; Dedek, Jan; Ozana, Stepan

2017-06-01

This article deals with study of possible connection of the REXcontrols platform with Raspberry Pi based control system and Navio2 expansion board. This board is designed for development of autonomous robotic platforms type car, plane or multicopter. In this article, control system REXcontrols is introduced and its integration possibilities for control board Navio2 are discussed. The main discussed aspects are communication possibilities of the REXcontrols system with external scripts which further on allow control of this board. The main reasons for this undertaking are vast possibilities of archiving, visualization, signal processing and control which REXcontrols system allows. The control itself of the navio2 board is done through numerous interfaces. Specifically it is a pair of SPI data buses, an I2C data bus, UART and multiple GPIO pins. However, since REXcontrols control system has only limited access to these data buses, it is necessary to establish the communication through external scripts. For this purpose REXcontrols is equipped with mechanisms; SILO, EPC and REXLANG which are described in the article. Due to its simple implementation into REXcontrols and the option to utilize available libraries for communication with Navio2 board in external script, an EPC block was selected for the final implementation.
Robust hydraulic position controller by a fuzzy state controller

International Nuclear Information System (INIS)

Zhao, T.; Van der Wal, A.J.

1994-01-01

In nuclear industry, one of the most important design considerations of controllers is their robustness. Robustness in this context is defined as the ability of a system to be controlled in a stable way over a wide range of system parameters. Generally the systems to be controlled are linearized, and stability is subsequently proven for this idealized system. By combining classical control theory and fuzzy set theory, a new kind of state controller is proposed and successfully applied to a hydraulic position servo with excellent robustness against variation of system parameters

Robust motion control of oscillatory-base manipulators h∞-control and sliding-mode-control-based approaches

CERN Document Server

Toda, Masayoshi

2016-01-01

This book provides readers with alternative robust approaches to control design for an important class of systems characteristically associated with ocean-going vessels and structures. These systems, which include crane vessels, on-board cranes, radar gimbals, and a conductivity temperature and depth winch, are modelled as manipulators with oscillating bases. One design approach is based on the H-infinity control framework exploiting an effective combination of PD control, an extended matrix polytope and a robust stability analysis method with a state-dependent coefficient form. The other is based on sliding-mode control using some novel nonlinear sliding surfaces. The model demonstrates how successful motion control can be achieved by suppressing base oscillations and in the presence of uncertainties. This is important not only for ocean engineering systems in which the problems addressed here originate but more generally as a benchmark platform for robust motion control with disturbance rejection. Researche...
Delta-Domain Predictive Control and Identification for Control

DEFF Research Database (Denmark)

Lauritsen, Morten Bach

1997-01-01

The present thesis is concerned with different aspects of modelling, control and identification of linear systems. Traditionally, discrete-time sampled-data systems are represented using shift-operator parametrizations. Such parametrizations are not suitable at fast sampling rates. An alternative...... minimum-variance predictor as a special case and to have a well-defined continuous-time limit. By means of this new prediction method a unified framework for discrete-time and continuous-time predictive control algorithms is developed. This contains a continuous-time like discrete-time predictive...... controller which is insensitive to the choice of sampling period and has a well-defined limit in the continuous-time case. Also more conventional discrete-time predictive control methods may be described within the unified approach. The predictive control algorithms are extended to frequency weighted...
Add Control: plant virtualization for control solutions in WWTP.

Science.gov (United States)

Maiza, M; Bengoechea, A; Grau, P; De Keyser, W; Nopens, I; Brockmann, D; Steyer, J P; Claeys, F; Urchegui, G; Fernández, O; Ayesa, E

2013-01-01

This paper summarizes part of the research work carried out in the Add Control project, which proposes an extension of the wastewater treatment plant (WWTP) models and modelling architectures used in traditional WWTP simulation tools, addressing, in addition to the classical mass transformations (transport, physico-chemical phenomena, biological reactions), all the instrumentation, actuation and automation & control components (sensors, actuators, controllers), considering their real behaviour (signal delays, noise, failures and power consumption of actuators). Its ultimate objective is to allow a rapid transition from the simulation of the control strategy to its implementation at full-scale plants. Thus, this paper presents the application of the Add Control simulation platform for the design and implementation of new control strategies at the WWTP of Mekolalde.
Dynamic control of quadruped robot with hierarchical control structure

International Nuclear Information System (INIS)

Wang, Yu-Zhang; Furusho, Junji; Okajima, Yosuke.

1988-01-01

For moving on irregular terrain, such as the inside of a nuclear power plant and outer space, it is generally recognized that the multilegged walking robot is suitable. This paper proposes a hierarchical control structure for the dynamic control of quadruped walking robots. For this purpose, we present a reduced order model which can approximate the original higher order model very well. Since this reduced order model does not require much computational time, it can be used in the real-time control of a quadruped walking robot. A hierarchical control experiment is shown in which the optimal control algorithm using a reduced order model is calculated by one microprocessor, and the other control algorithm is calculated by another microprocessor. (author)
Control Valve Stiction Identification, Modelling, Quantification and Control - A Review

Directory of Open Access Journals (Sweden)

Srinivasan Arumugam

2011-09-01

Full Text Available Most of the processes found in process industries exhibit undesirable nonlinearity due to backlash, saturation, hysteresis, stiction (friction, dead-zone and stuck-fault existing in control valves. The control valve is the actuator for most process control loops and, as the only moving part in the loop, its function is to implement the control action. If the control valve malfunctions, the performance of the control loop is likely to deteriorate, no matter how good the controller is. Commonly encountered control valve problems include nonlinear responses to the demand signal caused by effects such as stiction, dead-band or saturation. Because of these problems, the control loop may be oscillatory, which in turn may cause oscillations in many process variables causing a range of operational problems including increased valve wear. Understanding nonlinear behaviour of control valves in order to maintain the quality of the end products in the industry, this review article surveys the identification, modelling, estimation and design of dynamic models of stiction nonlinearity and providing appropriate controller to obtain optimum responses of the process. The primary objective of this work is to present state-of-art-review of common nonlinear problems associated with mechanical and chemical processes for encouraging researchers, practicing engineers working in this field, so that readers can invent their goals for future research work on nonlinear systems identification and control.
Hospital visitors as controls in case-control studies

Directory of Open Access Journals (Sweden)

Gulnar Azevedo S Mendonça

2001-10-01

Full Text Available OBJECTIVE: Selecting controls is one of the most difficult tasks in the design of case-control studies. Hospital controls may be inadequate and random controls drawn from the base population may be unavailable. The aim was to assess the use of hospital visitors as controls in a case-control study on the association of organochlorinated compounds and other risk factors for breast cancer conducted in the main hospital of the "Instituto Nacional de Câncer" -- INCA (National Cancer Institute in Rio de Janeiro (Brazil. METHODS: The study included 177 incident cases and 377 controls recruited among female visitors. Three different models of control group composition were compared: Model 1, with all selected visitors; Model 2, excluding women visiting relatives with breast cancer; and Model 3, excluding all women visiting relatives with any type of cancer. Odds ratios (OR and 95% confidence intervals were calculated to test the associations. RESULTS: Age-adjusted OR for breast cancer associated with risk factors other than family history of cancer, except smoking and breast size, were similar in the three models. Regarding family history of all cancers, except for breast cancer, there was a decreased risk in Models 1 and 2, while in Model 3 there was an increased risk, but not statistically significant. Family history of breast cancer was a risk factor in Models 2 and 3, but no association was found in Model 1. In multivariate analysis a significant risk of breast cancer was found when there was a family history of breast cancer in Models 2 and 3 but not in Model 1. CONCLUSIONS: These results indicate that while investigating risk factors unrelated to family history of cancer, the use of hospital visitors as controls may be a valid and feasible alternative.
Automatic control design procedures for restructurable aircraft control

Science.gov (United States)

Looze, D. P.; Krolewski, S.; Weiss, J.; Barrett, N.; Eterno, J.

1985-01-01

A simple, reliable automatic redesign procedure for restructurable control is discussed. This procedure is based on Linear Quadratic (LQ) design methodologies. It employs a robust control system design for the unfailed aircraft to minimize the effects of failed surfaces and to extend the time available for restructuring the Flight Control System. The procedure uses the LQ design parameters for the unfailed system as a basis for choosing the design parameters of the failed system. This philosophy alloys the engineering trade-offs that were present in the nominal design to the inherited by the restructurable design. In particular, it alloys bandwidth limitations and performance trade-offs to be incorporated in the redesigned system. The procedure also has several other desirable features. It effectively redistributes authority among the available control effectors to maximize the system performance subject to actuator limitations and constraints. It provides a graceful performance degradation as the amount of control authority lessens. When given the parameters of the unfailed aircraft, the automatic redesign procedure reproduces the nominal control system design.
Wind turbine control with constraint handling: a model predictive control approach

DEFF Research Database (Denmark)

Henriksen, Lars Christian; Hansen, Morten Hartvig; Poulsen, Niels Kjølstad

2012-01-01

on model predictive control, a control method well suited for constraint handling. The performance of the presented controller during an extreme operating gust is compared to that of a proportional-integral controller with integrator anti-windup. Furthermore, the presented controller-s capability...
Advanced Emissions Control Development Program: Mercury Control

International Nuclear Information System (INIS)

Evans, A.P.; Redinger, K.W.; Holmes, M.J.

1997-07-01

McDermott Technology, Inc. (a subsidiary of Babcock ampersand Wilcox) is conducting the Advanced Emissions Control Development Project (AECDP) which is aimed at the development of practical, cost-effective strategies for reducing the emissions of hazardous air pollutants (HAPS) from coal-fired electric utility plants. The need for such controls may arise as the US Environmental Protection Agency (EPA) proceeds with implementation of requirements set forth in the Clean Air Act Amendments (CAAA's) of 1990. Promulgation of air toxics emissions regulations for electric utility plants could dramatically impact utilities burning coal, their industrial and residential customers, and the coal industry. AECDP project work will supply the information needed by utilities to respond to potential HAPs regulations in a timely, cost-effective, enviromnentally-sound manner which supports the continued use of the Nation's abundant reserves of coal, such as those in the State of Ohio. The development work is being carried out using the 10 MW Clean Environment Development Facility wherein air toxics emissions control strategies can be developed under controlled conditions. The specific objectives of the project are to (1) measure and understand production and partitioning of air toxics species for a variety of coals, (2) optimize the air toxics removal performance of conventional flue gas cleanup systems, (3) develop advanced air toxics emissions control concepts, (4) develop and validate air toxics emissions measurement and monitoring techniques, and (5) establish a comprehensive, self-consistent air toxics data library. This project is supported by the Department of Energy, the Ohio Coal Development Office within the Ohio Department of Development and Babcock ampersand Wilcox. A comprehensive assessment of HAP emissions from coal-fired electric utility boilers sponsored by the Department of Energy and the Electric Power Research Institute concluded that with the exception of
Device for coupling a control rod and control rod drive

International Nuclear Information System (INIS)

Nishioka, Kazuya.

1975-01-01

Object: To obtain simple and reliable coupling between a control rod and control rod drive by equipping the lower end of the control rod with an extension provided with lateral protuberances and forming the upper end of an index tube with a recess provided with lateral holes. Structure: The tapering central extension of the control rod is inserted into the recess by lowering the control rod, and then it is further inserted by causing frictional movement of the inclined surfaces of lateral protuberances in frictional contact with guide surfaces. When the lateral protuberances are brought into contact with a stepped portion, the control rod is rotated to fit the lateral protuberances into the lateral holes. In this way, the control rod is coupled to the index tube of the control rod drive. (Yoshino, Y.)
A four-axis hand controller for helicopter flight control

Science.gov (United States)

Demaio, Joe

1993-01-01

A proof-of-concept hand controller for controlling lateral and longitudinal cyclic pitch, collective pitch and tail rotor thrust was developed. The purpose of the work was to address problems of operator fatigue, poor proprioceptive feedback and cross-coupling of axes associated with many four-axis controller designs. The present design is an attempt to reduce cross-coupling to a level that can be controlled with breakout force, rather than to eliminate it entirely. The cascaded design placed lateral and longitudinal cyclic in their normal configuration. Tail rotor thrust was placed atop the cyclic controller. A left/right twisting motion with the wrist made the control input. The axis of rotation was canted outboard (clockwise) to minimize cross-coupling with the cyclic pitch axis. The collective control was a twist grip, like a motorcycle throttle. Measurement of the amount of cross-coupling involved in pure, single-axis inputs showed cross coupling under 10 percent of full deflection for all axes. This small amount of cross-coupling could be further reduced with better damping and force gradient control. Fatigue was not found to be a problem, and proprioceptive feedback was adequate for all flight tasks executed.
Control rod drives

International Nuclear Information System (INIS)

Nakamura, Akira.

1984-01-01

Purpose: To enable to monitor the coupling state between a control rod and a control rod drive. Constitution: After the completion of a control rod withdrawal, a coolant pressure is applied to a control rod drive being adjusted so as to raise only the control rod drive and, in a case where the coupling between the control rod drive and the control rod is detached, the former is elevated till it contacts the control rod and then stopped. The actual stopping position is detected by an actual position detection circuit and compared with a predetermined position stored in a predetermined position detection circuit. If both of the positions are not aligned with each other, it is judged by a judging circuit that the control rod and the control rod drives are not combined. (Sekiya, K.)
Controllability analysis of decentralised linear controllers for polymeric fuel cells

Energy Technology Data Exchange (ETDEWEB)

Serra, Maria; Aguado, Joaquin; Ansede, Xavier; Riera, Jordi [Institut de Robotica i Informatica Industrial, Universitat Politecnica de Catalunya - Consejo Superior de Investigaciones Cientificas, C. Llorens i Artigas 4, 08028 Barcelona (Spain)

2005-10-10

This work deals with the control of polymeric fuel cells. It includes a linear analysis of the system at different operating points, the comparison and selection of different control structures, and the validation of the controlled system by simulation. The work is based on a complex non linear model which has been linearised at several operating points. The linear analysis tools used are the Morari resiliency index, the condition number, and the relative gain array. These techniques are employed to compare the controllability of the system with different control structures and at different operating conditions. According to the results, the most promising control structures are selected and their performance with PI based diagonal controllers is evaluated through simulations with the complete non linear model. The range of operability of the examined control structures is compared. Conclusions indicate good performance of several diagonal linear controllers. However, very few have a wide operability range. (author)
Controlling You Watching Me: Measuring Perception Control on Social Media.

Science.gov (United States)

Keep, Melanie; Attrill-Smith, Alison

2017-09-01

Online self-presentation assumes that individuals intentionally control how others perceive them based on their online behaviors. Existing tools are limited in their ability to measure this notion of perception control and there is little understanding around factors which may affect the desire for perception control. This article reports on the development of a perception control scale and comparisons of perception control across age and between genders. A total of 222 participants completed an online survey with items measuring perception control and participant demographics. A principal component analysis revealed a one-factor, 12-item scale explaining 41.14% of the variance. Perception control was found to increase with age and did not differ between genders. Results are consistent with existing impression management research suggesting that while participants of both genders desire to control how others perceive them, as a person's sense of self stabilizes over time, they are less motivated to change their behaviors to control others' impressions of them.
Predictive Function Control for Communication-Based Train Control (CBTC Systems

Directory of Open Access Journals (Sweden)

Bing Bu

2013-01-01

Full Text Available In Communication-Based Train Control (CBTC systems, random transmission delays and packet drops are inevitable in the wireless networks, which could result in unnecessary traction, brakes or even emergency brakes of trains, losses of line capacity and passenger dissatisfaction. This paper applies predictive function control technology with a mixed H2/∞ control approach to improve the control performances. The controller is in the state feedback form and satisfies the requirement of quadratic input and state constraints. A linear matrix inequality (LMI approach is developed to solve the control problem. The proposed method attenuates disturbances by incorporating H2/∞ into the control scheme. The control command from the automatic train operation (ATO is included in the reward function to optimize the train's running profile. The influence of transmission delays and packet drops is alleviated through improving the performances of the controller. Simulation results show that the method is effective to improve the performances and robustness of CBTC systems.
Birth Control

Science.gov (United States)

Birth control, also known as contraception, is designed to prevent pregnancy. Birth control methods may work in a number of different ... eggs that could be fertilized. Types include birth control pills, patches, shots, vaginal rings, and emergency contraceptive ...
Integrated controls

International Nuclear Information System (INIS)

Hollaway, F.W.

1985-01-01

During 1984, all portions of the Nova control system that were necessary for the support of laser activation and completion of the Nova project were finished and placed in service on time. The Nova control system has been unique in providing, on schedule, the capabilities required in the central control room and in various local control areas throughout the facility. The ambitious goal of deploying this system early enough to use it as an aid in the activation of the laser was accomplished; thus the control system made a major contribution to the completion of Nova activation on schedule. Support and enhancement activities continued during the year on the VAX computer systems, central control room, operator consoles and displays, Novanet data communications network, system-level software for both the VAX and LSI-11 computers, Praxis control system computer language, software management tools, and the development system, which includes office terminals. Computational support was also supplied for a wide variety of test fixtures required by the optical and mechanical subsystems. Significant new advancements were made in four areas in integrated controls this year: the integration software (which includes the shot scheduler), the Praxis language, software quality assurance audit, and software development and data handling. A description of the accomplishments in each of these areas follows
Evaluation of voice control, touch panel control and assistant control during steering of an endoscope

NARCIS (Netherlands)

Punt, Marius M.; Stefels, Coen N.; Grimbergen, Cornelis A.; Dankelman, Jenny

2005-01-01

The increasing amount of equipment used in the Operating Room ( OR) asks for ergonomical user interfaces. The aim of this study was to investigate in a pelvi-trainer setting the efficiency, reliability and user satisfaction of voice control, touch panel control and conventional manual control by an
Model Predictive Controller Combined with LQG Controller and Velocity Feedback to Control the Stewart Platform

DEFF Research Database (Denmark)

Nadimi, Esmaeil Sharak; Bak, Thomas; Izadi-Zamanabadi, Roozbeh

2006-01-01

The main objective of this paper is to investigate the erformance and applicability of two GPC (generalized predictive control) based control methods on a complete benchmark model of the Stewart platform made in MATLAB V6.5. The first method involves an LQG controller (Linear Quadratic Gaussian...
Coordinate control of integral reactor based on single neuron PID controller

International Nuclear Information System (INIS)

Liu Yan; Xia Hong

2014-01-01

As one of the main type of reactors in the future, the development of the integral reactor has attracted worldwide attention. On the basis of understanding the background of the integral reactor, the author will be familiar with and master the power control of reactor and the feedwater flow control of steam generator, and the speed control of turbine (turbine speed control is associated with the turbine load control). According to the expectative program 'reactor power following turbine load' of the reactor, it will make coordinate control of the three and come to a overall control scheme. The author will use the supervisory learning algorithm of Hebb for single neuron PID controller with self-adaptation to study the coordinate control of integral reactor. Compared with conventional PI or PID controller, to a certain extent, it solves the problems that traditional PID controller is not easy to tune real-time parameters and lack of effective control for a number of complex processes and slow-varying parameter systems. It improves the security, reliability, stability and flexibility of control process and achieves effective control of the system. (authors)

Control apparatus

International Nuclear Information System (INIS)

Doll, D.W.

1977-01-01

A nuclear reactor system is described in which flexible control rods are used to enable insertion of the control rods into guide holes in the core which are distributed over an area larger than the cross section of the control rod penetration in the reactor pressure vessel. Guide tubes extend from the penetration and fan out to the guide holes for guiding the control rods from the penetration to the guide holes
Control strategies for demand controlled ventilation in dwellings

DEFF Research Database (Denmark)

Nielsen, Toke Rammer; Drivsholm, Christian

2011-01-01

and efficient fans is becoming the standard solution. The building regulation requirement for air change in dwellings is often a constant value that has been chosen to avoid moisture related problems in the indoor environment. This required air change is sometimes sufficient, sometimes too low and sometimes too....... In the studied house two control strategies were tested. A simple strategy where all sensors and controls were located in the air handling unit and only the speed of the fans can be controlled, and a complex strategy where sensors were placed in each room and where individual control of air flow in each room...
Fusion Control of Flexible Logic Control and Neural Network

Directory of Open Access Journals (Sweden)

Lihua Fu

2014-01-01

Full Text Available Based on the basic physical meaning of error E and error variety EC, this paper analyzes the logical relationship between them and uses Universal Combinatorial Operation Model in Universal Logic to describe it. Accordingly, a flexible logic control method is put forward to realize effective control on multivariable nonlinear system. In order to implement fusion control with artificial neural network, this paper proposes a new neuron model of Zero-level Universal Combinatorial Operation in Universal Logic. And the artificial neural network of flexible logic control model is implemented based on the proposed neuron model. Finally, stability control, anti-interference control of double inverted-pendulum system, and free walking of cart pendulum system on a level track are realized, showing experimentally the feasibility and validity of this method.
Control of Bioprocesses

DEFF Research Database (Denmark)

Huusom, Jakob Kjøbsted

2015-01-01

The purpose of bioprocess control is to ensure that the plant operates as designed. This chapter presents the fundamental principles for control of biochemical processes. Through examples, the selection of manipulated and controlled variables in the classical reactor configurations is discussed, so...... are control objectives and the challenges in obtaining good control of the bioreactor. The objective of this chapter is to discuss the bioreactor control problems and to highlight some general traits that distinguish operation of bioprocesses from operation of processes in the conventional chemical process...... industries. It also provides a number of typical control loops for different objectives. A brief introduction to the general principles of process control, the PID control algorithm is discussed, and the design and effect of tuning are shown in an example. Finally, a discussion of novel, model-free control...
Power control method for load-frequency control operation in BWRs

International Nuclear Information System (INIS)

Ie, Shin-ichiroo; Ohgo, Yu-kiharu; Itou, Tetsuo; Shida, Tooichi

1991-01-01

The preliminary design of an advanced power control method for fast load-following [load frequency control (LFC)] maneuvers in a boiling water reactor (BWR) is described in this paper. Application of a multivariable control method using an optimal linear quadratic (LQ) regulator theory effectively improves control system performance when system variables have significant interactions such as in BWRs. The control problem, however, demands strict constraints on system variable from the standpoint of plant operation. These constraints require the control system to have a nonlinear property for better improvement. Therefore, the effectiveness of LQ control is limited by these constraints, because it is based on a linear model. A new method is needed to compensate for the nonlinear property. In this study, the authors propose a new method using fuzzy reasoning with LQ control to achieve nonlinear compensation
Pressure control of hydraulic servo system using proportional control valve

International Nuclear Information System (INIS)

Yang, Kyong Uk; Oh, In Ho; Lee, Ill Yeong

1999-01-01

The purpose of this study is to develop a control scheme for the hydraulic servo system which can rapidly control the pressure in a hydraulic cylinder with very short stroke. Compared with the negligible stroke of the cylinder in the system, the flow gain of the proportional pressure control valve constituting the hydraulic servo system is relatively large and the time delay on the response of the valve is quite long. Therefore, the pressure control system, in this study tends to get unstable during operations. Considering the above mentioned characteristics of the system, a two-degree-of-freedom control scheme, composed of the I-PDD 2 ... feedback compensator and the feedforward controller, is proposed. The reference model scheme is used in deciding the parameters of the controllers. The validity of the proposed control scheme is confirmed through the experiments
The SNS Resonance Control Cooling System Control Valve Upgrade Performance

International Nuclear Information System (INIS)

Williams, Derrick C.; Schubert, James Phillip; Tang, Johnny Y.

2008-01-01

The normal-conducting linac of the Spallation Neutron Source (SNS) uses 10 separate Resonance Control Cooling System (RCCS) water skids to control the resonance of 6 Drift Tube Linac (DTL) and 4 Coupled Cavity Linac (CCL) accelerating structures. The RCCS water skids use 2 control valves; one to regulate the chilled water flow and the other to bypass water to a chilled water heat exchanger. These valves have hydraulic actuators that provide position and feedback to the control system. Frequency oscillations occur using these hydraulic actuators due to their coarse movement and control of the valves. New pneumatic actuator and control positioners have been installed on the DTL3 RCCS water skid to give finer control and regulation of DTL3 cavity temperature. This paper shows a comparison of resonance control performance for the two valve configurations.
Control rod assembly

International Nuclear Information System (INIS)

Takahashi, Akio.

1982-01-01

Purpose: To enable reliable insertion and drops of control rods, as well as insure a sufficient flow rate of coolants flowing through the control rods for attaining satisfactory cooling thereof to enable relexation of thermal stress resulted to rectifying mechanisms or the likes. Constitution: To the outer circumference of a control rod contained vertically movably within a control rod guide tube, resistive members are retractably provided in such a way as to project to close the gap between outer circumference of the control rod and the inner surface of the control rod guide tube upon engagement of a gripper of control rod drives, and retract upon release of the engagement of the gripper. Thus, since the resistive members project to provide a greater resistance to the coolants flowing between them and the control rod guide tube in the normal operation where the gripper is engaged to drive the control rod by the control rod drives, a major part of the coolant flowing into the control rod guide tube flows into the control rod. This enables to cool the control rod effectively and make the temperature distribution uniform for the coolant flowing from the upper end of the control rod guide tube to thereby attain the relaxation of the thermal stress resulted in the rectifying mechanisms or the likes. (Moriyama, K.)
Nuclear power plant control room operator control and monitoring tasks

International Nuclear Information System (INIS)

Bovell, C.R.; Beck, M.G.; Carter, R.J.

1998-01-01

Oak Ridge National Laboratory is conducting a research project the purpose of which is to develop the technical bases for regulatory review criteria for use in evaluating the safety implications of human factors associated with the use of artificial intelligence and expert systems, and with advanced instrumentation and control (I and C) systems in nuclear power plants (NPP). This report documents the results from Task 8 of that project. The primary objectives of the task was to identify the scope and type of control and monitoring tasks now performed by control-room operators. Another purpose was to address the types of controls and safety systems needed to operate the nuclear plant. The final objective of Task 8 was to identify and categorize the type of information and displays/indicators required to monitor the performance of the control and safety systems. This report also discusses state-of-the-art controls and advanced display devices which will be available for use in control-room retrofits and in control room of future plants. The fundamental types of control and monitoring tasks currently conducted by operators can be divided into four classifications: function monitoring tasks, control manipulation tasks, fault diagnostic tasks, and administrative tasks. There are three general types of controls used in today's NPPs, switches, pushbuttons, and analog controllers. Plant I and C systems include components to achieve a number of safety-related functions: measuring critical plant parameters, controlling critical plant parameters within safety limits, and automatically actuating protective devices if safe limits are exceeded. The types of information monitored by the control-room operators consist of the following parameters: pressure, fluid flow and level, neutron flux, temperature, component status, water chemistry, electrical, and process and area radiation. The basic types of monitoring devices common to nearly all NPP control rooms include: analog meters
Finite Control Set Model Predictive Control for Multiple Distributed Generators Microgrids

Science.gov (United States)

Babqi, Abdulrahman Jamal

This dissertation proposes two control strategies for AC microgrids that consist of multiple distributed generators (DGs). The control strategies are valid for both grid-connected and islanded modes of operation. In general, microgrid can operate as a stand-alone system (i.e., islanded mode) or while it is connected to the utility grid (i.e., grid connected mode). To enhance the performance of a micrgorid, a sophisticated control scheme should be employed. The control strategies of microgrids can be divided into primary and secondary controls. The primary control regulates the output active and reactive powers of each DG in grid-connected mode as well as the output voltage and frequency of each DG in islanded mode. The secondary control is responsible for regulating the microgrid voltage and frequency in the islanded mode. Moreover, it provides power sharing schemes among the DGs. In other words, the secondary control specifies the set points (i.e. reference values) for the primary controllers. In this dissertation, Finite Control Set Model Predictive Control (FCS-MPC) was proposed for controlling microgrids. FCS-MPC was used as the primary controller to regulate the output power of each DG (in the grid-connected mode) or the voltage of the point of DG coupling (in the islanded mode of operation). In the grid-connected mode, Direct Power Model Predictive Control (DPMPC) was implemented to manage the power flow between each DG and the utility grid. In the islanded mode, Voltage Model Predictive Control (VMPC), as the primary control, and droop control, as the secondary control, were employed to control the output voltage of each DG and system frequency. The controller was equipped with a supplementary current limiting technique in order to limit the output current of each DG in abnormal incidents. The control approach also enabled smooth transition between the two modes. The performance of the control strategy was investigated and verified using PSCAD/EMTDC software
Plasma control device

International Nuclear Information System (INIS)

Takase, Haruhiko.

1987-01-01

Purpose: To obtain the optimum controllability for the plasmas and the thermonuclear device by selectively executing control operation for proportion, integration and differentiation (PID) by first and second controllers respectively based on selection instruction signals. Constitution: Deviation between a vertical direction equilibrium position: Zp as the plasma status amount measured in a measuring section and an aimed value Zref thereof is inputted to a first PID selection controller. The first controller selectively executes one of the PID control operations in accordance with the first selection signal instruction instructed by a PID control operation instruction circuit. Further, Zp is also inputted to a second PID selection controller, which selectively executes one of the PID control operations in accordance with the second selection instruction signal in the same manner as in the first controller. The deviation amount u between operations signals u1 and u2 from the first and second PID selection controllers is inputted to a power source to thereby supply a predetermined current value to control coils that generate equilibrium magnetic fields for making the vertical direction equilibrium position of plasmas constant. (Kamimura, M.)
Applied predictive control

CERN Document Server

Sunan, Huang; Heng, Lee Tong

2002-01-01

The presence of considerable time delays in the dynamics of many industrial processes, leading to difficult problems in the associated closed-loop control systems, is a well-recognized phenomenon. The performance achievable in conventional feedback control systems can be significantly degraded if an industrial process has a relatively large time delay compared with the dominant time constant. Under these circumstances, advanced predictive control is necessary to improve the performance of the control system significantly. The book is a focused treatment of the subject matter, including the fundamentals and some state-of-the-art developments in the field of predictive control. Three main schemes for advanced predictive control are addressed in this book: • Smith Predictive Control; • Generalised Predictive Control; • a form of predictive control based on Finite Spectrum Assignment. A substantial part of the book addresses application issues in predictive control, providing several interesting case studie...
Generic device controller for accelerator control systems

International Nuclear Information System (INIS)

Mariotti, R.; Buxton, W.; Frankel, R.; Hoff, L.

1987-01-01

A new distributed intelligence control system has become operational at the AGS for transport, injection, and acceleration of heavy ions. A brief description of the functionality of the physical devices making up the system is given. An attempt has been made to integrate the devices for accelerator specific interfacing into a standard microprocessor system, namely, the Universal Device Controller (UDC). The main goals for such a generic device controller are to provide: local computing power; flexibility to configure; and real time event handling. The UDC assemblies and software are described
Controlling chaos in Internet congestion control model

International Nuclear Information System (INIS)

Chen Liang; Wang Xiaofan; Han Zhengzhi

2004-01-01

The TCP end-to-end congestion control plus RED router queue management can be modeled as a discrete-time dynamical system, which may create complex bifurcating and chaotic behavior. Based on the basic features of the TCP-RED model, we propose a time-dependent delayed feedback control algorithm to control chaos in the system by perturbing the accessible RED parameter p max . This method is able to stabilized a router queue occupancy at a level without knowing the exact knowledge of the network. Further, we study the situation of the presence of the UDP traffic
Associational control

DEFF Research Database (Denmark)

Hvid, Helge Søndergaard; Lund, Henrik Lambrecht; Grosen, Sidsel Lond

2010-01-01

Over the last 30 years, the concept of control has had a central position in research into the psychological working environment. Control has been understood as individual autonomy and individual opportunities for development. This article examines whether the concept of control has the same key...
Rail Vehicle Vibrations Control Using Parameters Adaptive PID Controller

Directory of Open Access Journals (Sweden)

Muzaffer Metin

2014-01-01

Full Text Available In this study, vertical rail vehicle vibrations are controlled by the use of conventional PID and parameters which are adaptive to PID controllers. A parameters adaptive PID controller is designed to improve the passenger comfort by intuitional usage of this method that renews the parameters online and sensitively under variable track inputs. Sinusoidal vertical rail misalignment and measured real rail irregularity are considered as two different disruptive effects of the system. Active vibration control is applied to the system through the secondary suspension. The active suspension application of rail vehicle is examined by using 5-DOF quarter-rail vehicle model by using Manchester benchmark dynamic parameters. The new parameters of adaptive controller are optimized by means of genetic algorithm toolbox of MATLAB. Simulations are performed at maximum urban transportation speed (90 km/h of the rail vehicle with ±5% load changes of rail vehicle body to test the robustness of controllers. As a result, superior performance of parameters of adaptive controller is determined in time and frequency domain.
Tube Model Predictive Control with an Auxiliary Sliding Mode Controller

Directory of Open Access Journals (Sweden)

Miodrag Spasic

2016-07-01

Full Text Available This paper studies Tube Model Predictive Control (MPC with a Sliding Mode Controller (SMC as an auxiliary controller. It is shown how to calculate the tube widths under SMC control, and thus how much the constraints of the nominal MPC have to be tightened in order to achieve robust stability and constraint fulfillment. The analysis avoids the assumption of infinitely fast switching in the SMC controller.
Control rod drives

International Nuclear Information System (INIS)

Futatsugi, Masao.

1980-01-01

Purpose: To secure the reactor operation safety by the provision of a fluid pressure detecting section for control rod driving fluid and a control rod interlock at the midway of the flow pass for supplying driving fluid to the control rod drives. Constitution: Between a driving line and a direction control valve are provided a pressure detecting portion, an alarm generating device, and a control rod inhibition interlock. The driving fluid from a driving fluid source is discharged by way of a pump and a manual valve into the reactor in which the control rods and reactor fuels are contained. In addition, when the direction control valve is switched and the control rods are inserted and extracted by the control rod drives, the pressure in the driving line is always detected by the pressure detection section, whereby if abnormal pressure is resulted, the alarm generating device is actuated to warn the abnormality and the control rod inhibition interlock is actuated to lock the direction control valve thereby secure the safety operation of the reactor. (Seki, T.)
Control rod drive

International Nuclear Information System (INIS)

Okutani, Tetsuro.

1988-01-01

Purpose: To provide a simple and economical control rod drive using a control circuit requiring no pulse circuit. Constitution: Control rods in a BWR type reactor are driven by hydraulic pressure and inserted or withdrawn in the direction of applying the hydraulic pressure. The direction of the hydraulic pressure is controlled by a direction control valve. Since the driving for the control rod is extremely important in view of the operation, a self diagnosis function is disposed for rapid inspection of possible abnormality. In the present invention, two driving contacts are disposed each by one between the both ends of a solenoid valve of the direction control valve for driving the control rod and the driving power source, and diagnosis is conducted by alternately operating them. Therefore, since it is only necessary that the control circuit issues a driving instruction only to one of the two driving contacts, the pulse circuit is no more required. Further, since the control rod driving is conducted upon alignment of the two driving instructions, the reliability of the control rod drive can be improved. (Horiuchi, T.)
Neural PID Control Strategy for Networked Process Control

Directory of Open Access Journals (Sweden)

Jianhua Zhang

2013-01-01

Full Text Available A new method with a two-layer hierarchy is presented based on a neural proportional-integral-derivative (PID iterative learning method over the communication network for the closed-loop automatic tuning of a PID controller. It can enhance the performance of the well-known simple PID feedback control loop in the local field when real networked process control applied to systems with uncertain factors, such as external disturbance or randomly delayed measurements. The proposed PID iterative learning method is implemented by backpropagation neural networks whose weights are updated via minimizing tracking error entropy of closed-loop systems. The convergence in the mean square sense is analysed for closed-loop networked control systems. To demonstrate the potential applications of the proposed strategies, a pressure-tank experiment is provided to show the usefulness and effectiveness of the proposed design method in network process control systems.

A Robust H∞ Controller for an UAV Flight Control System

Directory of Open Access Journals (Sweden)

J. López

2015-01-01

Full Text Available The objective of this paper is the implementation and validation of a robust H∞ controller for an UAV to track all types of manoeuvres in the presence of noisy environment. A robust inner-outer loop strategy is implemented. To design the H∞ robust controller in the inner loop, H∞ control methodology is used. The two controllers that conform the outer loop are designed using the H∞ Loop Shaping technique. The reference vector used in the control architecture formed by vertical velocity, true airspeed, and heading angle, suggests a nontraditional way to pilot the aircraft. The simulation results show that the proposed control scheme works well despite the presence of noise and uncertainties, so the control system satisfies the requirements.
Control rod displacement

International Nuclear Information System (INIS)

Nakazato, S.

1987-01-01

This patent describes a nuclear reactor including a core, cylindrical control rods, a single support means supporting the control rods from their upper ends in spaced apart positions and movable for displacing the control rods in their longitudinal direction between a first end position in which the control rods are fully inserted into the core and a second end position in which the control rods are retracted from the core, and guide means contacting discrete regions of the outer surface of each control rod at least when the control rods are in the vicinity of the second end position. The control rods are supported by the support means for longitudinal movement without rotation into and out of the core relative to the guide means to thereby cause the outer surface of the control rods to experience wear as a result of sliding contact with the guide means. The support means are so arranged with respect to the core and the guide means that it is incapable of rotation relative to the guide means. The improvement comprises displacement means being operatively coupled to a respective one of the control rods for periodically rotating the control rod in a single angular direction through an angle selected to change the locations on the outer surfaces of the control rods at which the control rods are contacted by the guide means during subsequent longitudinal movement of the control rods
Robust sampled-data control of hydraulic flight control actuators

OpenAIRE

Kliffken, Markus Gustav

1997-01-01

In todays flight-by-wire systems the primary flight control surfaces of modern commercial and transport aircraft are driven by electro hydraulic linear actuators. Changing flight conditions as well as nonlinear actuator dynamics may be interpreted as parameter uncertainties of the linear actuator model. This demands a robust design for the controller. Here the parameter space design is used for the direct sampled-data controller synthesis. Therefore, a static output controller is choosen, the...
The relationship between administrative court control and legislative control

International Nuclear Information System (INIS)

Beckmann, M.

1986-01-01

The legislator can determine the extent of control of administrative courts by reduction of substantive conditions. The author has the opinion that the judicial control cannot be stricter than the legislative control. For the range of the control of administrative courts is decisive, to what extent the legislator is forced to proper legislative settlements. In this context the author discusses the Kalkar-decision of the Federal Constitutional Court of 1978. (CW) [de
Feedback control and adaptive control of the energy resource chaotic system

International Nuclear Information System (INIS)

Sun Mei; Tian Lixin; Jiang Shumin; Xu Jun

2007-01-01

In this paper, the problem of control for the energy resource chaotic system is considered. Two different method of control, feedback control (include linear feedback control, non-autonomous feedback control) and adaptive control methods are used to suppress chaos to unstable equilibrium or unstable periodic orbits. The Routh-Hurwitz criteria and Lyapunov direct method are used to study the conditions of the asymptotic stability of the steady states of the controlled system. The designed adaptive controller is robust with respect to certain class of disturbances in the energy resource chaotic system. Numerical simulations are presented to show these results
Near Optimal Decentralized H-infinity Control: Bounded vs. Unbounded Controller Order

DEFF Research Database (Denmark)

Stoustrup, Jakob; Niemann, H.H.

1997-01-01

It is shown that for a class of decentralized control problems there does not exist a sequence of controllers of bounded order which obtains near optimal control. Neither does there exist an infinite dimensional optimal controller. Using the insight of the line of proof of these results, a heuris......It is shown that for a class of decentralized control problems there does not exist a sequence of controllers of bounded order which obtains near optimal control. Neither does there exist an infinite dimensional optimal controller. Using the insight of the line of proof of these results...
Structural Pest Control.

Science.gov (United States)

Kahn, M. S.; Hoffman, W. M.

This manual is designed for those who seek certification as pesticide applicators for industrial, institutional, structural, and health-related pest control. It is divided into six sections covering general pest control, wood-destroying organisms, bird control, fumigation, rodent control, and industrial weed control. The manual gives information…
Quality control in diagnostic immunohistochemistry: integrated on-slide positive controls.

Science.gov (United States)

Bragoni, A; Gambella, A; Pigozzi, S; Grigolini, M; Fiocca, R; Mastracci, L; Grillo, F

2017-11-01

Standardization in immunohistochemistry is a priority in modern pathology and requires strict quality control. Cost containment has also become fundamental and auditing of all procedures must take into account both these principles. Positive controls must be routinely performed so that their positivity guarantees the appropriateness of the immunohistochemical procedure. The aim of this study is to develop a low cost (utilizing a punch biopsy-PB-tool) procedure to construct positive controls which can be integrated in the patient's tissue slide. Sixteen frequently used control blocks were selected and multiple cylindrical samples were obtained using a 5-mm diameter punch biopsy tool, separately re-embedding them in single blocks. For each diagnostic immunoreaction requiring a positive control, an integrated PB-control section (cut from the appropriate PB-control block) was added to the top right corner of the diagnostic slide before immunostaining. This integrated control technique permitted a saving of 4.75% in total direct lab costs and proved to be technically feasible and reliable. Our proposal is easy to perform and within the reach of all pathology labs, requires easily available tools, its application costs is less than using external paired controls and ensures that a specific control for each slide is always available.
Reactor control device

International Nuclear Information System (INIS)

Kameda, Akiyuki.

1979-01-01

Purpose: To enable three types of controls, that is, level control, scram control and excess reactivity control required for a reactor by a same mechanism by feeding neutron absorber liquid and pressure control gas to several blind pipes provided in the reactor core. Constitution: A plurality of blind pipes are disposed spaced apart in a reactor core and connected by way of injection pipes to a neutron absorber liquid tank. A pressure regulator is connected to the blind pipes, to which pressure control gas is supplied. The neutron absorber liquid used herein consists of sodium, potassium or their alloy, or mercury as a basic substance incorporated with one or more selected from boron, tantalum, rhenium, europium or their compounds. The level control, scram control and excess reactivity control can be attained by moderating the pressure changes in the pressure control gas or by regulating the fluctuation in the liquid level. (Horiughi, T.)
Optimal control

CERN Document Server

Aschepkov, Leonid T; Kim, Taekyun; Agarwal, Ravi P

2016-01-01

This book is based on lectures from a one-year course at the Far Eastern Federal University (Vladivostok, Russia) as well as on workshops on optimal control offered to students at various mathematical departments at the university level. The main themes of the theory of linear and nonlinear systems are considered, including the basic problem of establishing the necessary and sufficient conditions of optimal processes. In the first part of the course, the theory of linear control systems is constructed on the basis of the separation theorem and the concept of a reachability set. The authors prove the closure of a reachability set in the class of piecewise continuous controls, and the problems of controllability, observability, identification, performance and terminal control are also considered. The second part of the course is devoted to nonlinear control systems. Using the method of variations and the Lagrange multipliers rule of nonlinear problems, the authors prove the Pontryagin maximum principle for prob...
Documenting control system functionality for digital control implementations

International Nuclear Information System (INIS)

Harber, J.; Borairi, M.; Tikku, S.; Josefowicz, A.

2006-01-01

In past CANDU designs, plant control was accomplished by a combination of digital control computers, analogue controllers, and hardwired relay logic. Functionality for these various control systems, each using different hardware, was documented in varied formats such as text based program specifications, relay logic diagrams, and other various specification documents. The choice of formats was influenced by the hardware used and often required different specialized skills for different applications. The programmable electronic systems in new CANDU designs are realized in a manner consistent with latest international standards (e.g., the IEC 61513 standard). New CANDU designs make extensive use of modern digital control technology, with the benefit that functionality can be implemented on a limited number of control platforms, reducing development and maintenance cost. This approach can take advantage of tools that allow the plant control system functional and performance requirements to be documented using graphical representations. Modern graphical methods supplemented by information databases can be used to provide a clear and comprehensive set of requirements for software and system development. Overview diagrams of system functionality provide a common understanding of the system boundaries and interfaces. Important requirements are readily traced through the development process. This improved reviewability helps to ensure consistency with the safety and and production design requirements of the system. Encapsulation of commonly used functions into custom-defined function blocks, such as typical motor control centre interfaces, process interlocks, median selects etc, eases the burden on designers to understand and analyze the detailed functionality of each instance of use of this logic. A library of encapsulated functions will be established for complex functions that are reused in the control logic development. By encapsulation and standardisation of such
Population-based versus hospital-based controls: are they comparable? Controles poblaciones frente a controles hospitalarios: ¿son comparables?

Directory of Open Access Journals (Sweden)

Alberto Ruano-Ravina

2008-12-01

Full Text Available Objective: To compare whether there are differences among hospital and population controls. Methods: Two case-control studies were conducted on lung cancer risk factors in the Santiago de Compostela Public Health District. Whereas one used randomly chosen census-based population controls, the other used consecutive hospital controls that went to the reference hospital for non-smoking-related trivial interventions. The differences were analyzed using logistic regression. The dependent variable was type of control (hospital or population. Results: Hospital controls had a similar tobacco habit than population controls, but consumed more alcohol. For those consuming more than 50 ml daily, the risk of being a hospital control was 4.83 (95%CI: 2.55-9.14. Conclusions: There may be some differences between hospital and population-based controls, which must be taken into account in the design of case-control studies. It is necessary to ascertain whether such differences are reproduced at other geographic locations and whether they can affect estimation of exposure-disease.Objetivo: Comparar si hay diferencias entre los controles poblacionales y los hospitalarios. Métodos: Se llevaron a cabo dos estudios de casos y controles sobre factores de riesgo de cáncer de pulmón en el Área Sanitaria de Santiago de Compostela. En uno de los estudios los controles fueron seleccionados aleatoriamente entre la población general, y en el otro los controles hospitalarios fueron incluidos de manera consecutiva entre los individuos que acudían al hospital por intervenciones quirúrgicas banales no relacionadas con el consumo de tabaco. Las diferencias fueron analizadas mediante regresión logística. La variable dependiente fue el tipo de control (hospitalario o poblacional. Resultados: Los controles hospitalarios y los poblacionales tenían un hábito tabáquico similar, pero los controles hospitalarios consumían más alcohol. Para los que consumían más de 50 ml
Supervisory control system implemented in programmable logical controller web server

OpenAIRE

Milavec, Simon

2012-01-01

In this thesis, we study the feasibility of supervisory control and data acquisition (SCADA) system realisation in a web server of a programmable logic controller. With the introduction of Ethernet protocol to the area of process control, the more powerful programmable logic controllers obtained integrated web servers. The web server of a programmable logic controller, produced by Siemens, will also be described in this thesis. Firstly, the software and the hardware equipment used for real...
Application of robust fuzzy control in power control of nuclear reactor

International Nuclear Information System (INIS)

Liu Lei; Luan Xiuchun; Jin Guangyuan; Yu Tao; Rao Su

2013-01-01

Robust-fuzzy controller based on T-S fuzzy model was designed for real-time controlling of nuclear reactor power and adapting to the load changing of power grid. Local controller was designed by means of state feedback technique, and the global controller was designed by parallel distributed compensation (PDC) method. The result of solving linear matrix inequalities (LMI) proves that this controller is stable. The simulation shows that the nuclear power can be well controlled in three typical conditions by this controller. (authors)
Adaptive control of discrete-time chaotic systems: a fuzzy control approach

International Nuclear Information System (INIS)

Feng Gang; Chen Guanrong

2005-01-01

This paper discusses adaptive control of a class of discrete-time chaotic systems from a fuzzy control approach. Using the T-S model of discrete-time chaotic systems, an adaptive control algorithm is developed based on some conventional adaptive control techniques. The resulting adaptively controlled chaotic system is shown to be globally stable, and its robustness is discussed. A simulation example of the chaotic Henon map control is finally presented, to illustrate an application and the performance of the proposed control algorithm
Notions of local controllability and optimal feedforward control for quantum systems

International Nuclear Information System (INIS)

Chakrabarti, Raj

2011-01-01

Local controllability is an essential concept for regulation and control of time-varying nonlinear dynamical systems; in the classical control logic it is at the foundation of neighboring optimal feedback and feedforward control. We introduce notions of local controllability suited to feedforward control of classical input disturbances in bilinear quantum systems evolving on projective spaces and Lie groups. Tests for local controllability based on a Gramian matrix analogous to the nonlinear local controllability Gramian, which allow assessment of which trajectories can be regulated by perturbative feedforward in the presence of classical input noise, are presented. These notions explicitly incorporate system bilinearity and the geometry of quantum states into the definition of local controllability of quantum systems. Associated feedforward strategies are described.
Notions of local controllability and optimal feedforward control for quantum systems

Energy Technology Data Exchange (ETDEWEB)

Chakrabarti, Raj, E-mail: rchakra@purdue.edu [School of Chemical Engineering, Purdue University, West Lafayette, IN 47907 (United States)

2011-05-06

Local controllability is an essential concept for regulation and control of time-varying nonlinear dynamical systems; in the classical control logic it is at the foundation of neighboring optimal feedback and feedforward control. We introduce notions of local controllability suited to feedforward control of classical input disturbances in bilinear quantum systems evolving on projective spaces and Lie groups. Tests for local controllability based on a Gramian matrix analogous to the nonlinear local controllability Gramian, which allow assessment of which trajectories can be regulated by perturbative feedforward in the presence of classical input noise, are presented. These notions explicitly incorporate system bilinearity and the geometry of quantum states into the definition of local controllability of quantum systems. Associated feedforward strategies are described.
Time-delay effects and simplified control fields in quantum Lyapunov control

International Nuclear Information System (INIS)

Yi, X X; Wu, S L; Wu, Chunfeng; Feng, X L; Oh, C H

2011-01-01

Lyapunov-based quantum control has the advantage that it is free from the measurement-induced decoherence and it includes the instantaneous information of the system in the control. The Lyapunov control is often confronted with time delay in the control fields and difficulty in practical implementations of the control. In this paper, we study the effect of time delay on the Lyapunov control and explore the possibility of replacing the control field with a pulse train or a bang-bang signal. The efficiency of the Lyapunov control is also presented through examining the convergence time of the system. These results suggest that the Lyapunov control is robust against time delay, easy to realize and effective for high-dimensional quantum systems.
Control rod drive

International Nuclear Information System (INIS)

Hawke, B.C.

1986-01-01

A reactor core, one or more control rods, and a control rod drive are described for selectively inserting and withdrawing the one or more control rods into and from the reactor core, which consists of: a support structure secured beneath the reactor core; control rod positioning means supported by the support structure for movably supporting the control rod for movement between a lower position wherein the control rod is located substantially beneath the reactor core and an upper position wherein at least an upper portion of the control rod extends into the reactor core; transmission means; primary drive means connected with the control rod positioning means by the transmission means for positioning the control rod under normal operating conditions; emergency drive means for moving the control rod from the lower position to the upper position under emergency conditions, the emergency drive means including a weight movable between an upper and a lower position, means for movably supporting the weight, and means for transmitting gravitational force exerted on the weight to the control rod positioning means to move the control rod upwardly when the weight is pulled downwardly by gravity; the transmission means connecting the control rod positioning means with the emergency drive means so that the primary drive means effects movement of the weight and the control rod in opposite directions under normal conditions, thus providing counterbalancing to reduce the force required for upward movement of the control rod under normal conditions; and restraint means for restraining the fall of the weight under normal operating conditions and disengaging the primary drive means to release the weight under emergency conditions
Optimal control of inverted pendulum system using PID controller, LQR and MPC

Science.gov (United States)

Varghese, Elisa Sara; Vincent, Anju K.; Bagyaveereswaran, V.

2017-11-01

Inverted pendulum is a highly nonlinear system. Here we propose an optimal control technique for the control of an inverted Pendulum - cart system. The system is modeled, linearized and controlled. Here, the control objective is to control the system such that when the cart reaches a desired position the inverted pendulum stabilizes in the upright position. Initially PID controller is used to control the system. Later, Linear Quadratic Regulator (LQR) a well-known optimal control technique which makes use of the states of the dynamical system and control input to frame the optimal control decision is used. Various combinations of both PID and LQR controllers are implemented. To validate the robustness of the controller, the system is simulated with and without disturbance. Finally the system is also controlled using Model Predictive controller (MPC). MPC has well predictive ability to calculate future events and implement necessary control actions. The performance of the system is compared and analyzed.

Gaining control

NARCIS (Netherlands)

Enden, van der E.; Laan, van der R.

2008-01-01

The article reports on the efforts of companies to find a solution for tax risk management, tax accounting and being in control. In trying to find a solution, companies work towards an integrated tax control framework (TCF), a tax risk management and control environment embedded in the internal
Applying model predictive control to power system frequency control

OpenAIRE

Ersdal, AM; Imsland, L; Cecilio, IM; Fabozzi, D; Thornhill, NF

2013-01-01

16.07.14 KB Ok to add accepted version to Spiral Model predictive control (MPC) is investigated as a control method which may offer advantages in frequency control of power systems than the control methods applied today, especially in presence of increased renewable energy penetration. The MPC includes constraints on both generation amount and generation rate of change, and it is tested on a one-area system. The proposed MPC is tested against a conventional proportional-integral (PI) cont...
Control of a mechanical gripper with a fuzzy controller; Control de una garra robotizada mediante un controlador borroso

Energy Technology Data Exchange (ETDEWEB)

Alberdi, J.; Barcala, J.M.; Gamero, E.; Navarrete, J.J.

1995-07-01

A fuzzy logic system is used to control a mechanical gripper. System is based in a NLX230 fuzzy micro controller. Control rules are programmed by a 68020 microprocessor in the micro controller memory. Stress and its derived are used as feedback signals in the control. This system can adapt its effort to the mechanical resistance of the object between the fingers.
Control of a mechanical gripper with a fuzzy controller; Control de una garra robotizada mediante un controlador borroso

Energy Technology Data Exchange (ETDEWEB)

Alberdi, J.; Barcala, J.M.; Gamero, E.; Navarrete, J.J.

1995-07-01

A fuzzy logic system is used to control a mechanical gripper. System is based in a NLX230 fuzzy micro controller. Control rules are programmed by a 68020 microprocessor in the micro controller memory. Stress and its derived are used as feedback signals in the control. This system can adapt its effort to the mechanical resistance of the object between the fingers. (Author)
Control rod

International Nuclear Information System (INIS)

Kawakami, Kazuo; Shimoshige, Takanori; Nishimura, Akira

1979-01-01

Purpose: A control rod has been developed, which provided a plurality of through-holes in the vicinity of the sheath fitting position, in order to flatten burn-up, of fuel rods in positions confronting a control rod. Thereby to facilitate the manufacture of the control rods and prevent fuel rod failures. Constitution: A plurality of through-holes are formed in the vicinity of the sheath fitting position of a central support rod to which a sheath for the control rod is fitted. These through-holes are arranged in the axial direction of the central support rod. Accordingly, burn-up of fuel rods confronting the control rods can be reduced by through-holes and fuel rod failures can be prevented. (Yoshino, Y.)
Distributed control software of high-performance control-loop algorithm

CERN Document Server

Blanc, D

1999-01-01

The majority of industrial cooling and ventilation plants require the control of complex processes. All these processes are highly important for the operation of the machines. The stability and reliability of these processes are leading factors identifying the quality of the service provided. The control system architecture and software structure, as well, are required to have high dynamical performance and robust behaviour. The intelligent systems based on PID or RST controllers are used for their high level of stability and accuracy. The design and tuning of these complex controllers require the dynamic model of the plant to be known (generally obtained by identification) and the desired performance of the various control loops to be specified for achieving good performances. The concept of having a distributed control algorithm software provides full automation facilities with well-adapted functionality and good performances, giving methodology, means and tools to master the dynamic process optimization an...
Micro controller application as x-ray machine's high voltage controller

International Nuclear Information System (INIS)

Wiranto Budi Santoso; Beny Syawaludin

2010-01-01

The micro controller application as x-ray machine's high voltage controller has been carried out. The purpose of this micro controller application is to give an accurate high voltage supply to the x-ray tube so that the x ray machine could produce the result as expected. The micro controller based X-ray machine's high voltage controller receives an input voltage from the keypad. This input value is displayed in the LCD (Liquid Crystal Display) screen. Then micro controller uses this input data to drive the stepper motor. The stepper motor adjusts the high voltage auto transformer's output according to the input value. The micro controller is programmed using BASCOM-B051 compiler. The test results show that the stepper motor could rotate according to an input value. (author)
Future control room design (modernization of control room systems)

International Nuclear Information System (INIS)

Reischl, Ludwig; Freitag, Timo; Dergel, Rene

2009-01-01

In the frame of lifetime extension for nuclear power plants the modernization of the complete safety and operational control technology will be digitalized. It is also recommended to modernize the operator facilities, monitoring systems in the control room, the back-up shut-down center and the local control stations. The authors summarize the reasons for the modernization recommendations and discuss possible solutions for display-oriented control rooms. A concept for control room backfitting includes generic requirements, requirements of the local authorities, ergonomic principles information content and information density, and the design process. The backfitting strategy should include a cooperation with the operational personnel, The quality assurance and training via simulator needs sufficient timing during the implementation of the backfitting.
Motion control report

CERN Document Server

2013-01-01

Please note this is a short discount publication. In today's manufacturing environment, Motion Control plays a major role in virtually every project.The Motion Control Report provides a comprehensive overview of the technology of Motion Control:* Design Considerations* Technologies* Methods to Control Motion* Examples of Motion Control in Systems* A Detailed Vendors List
Predistortion control device and method, assembly including a predistortion control device

NARCIS (Netherlands)

Kokkeler, Andre B.J.

2003-01-01

A predistortion control device (1). The device has a first predistortion control input connectable to a power amplifier output (21); a second predistortion control input (11) connectable to a signal contact of a predistortion device; and a predistortion control output (12) connectable to a control
A Wireless Low Power Valve Controller for Drip Irrigation Control Systems

Directory of Open Access Journals (Sweden)

Haijiang Tai

2014-03-01

Full Text Available Drip irrigation control systems in fields generally include a large number of sensors and valves; controlling these devices efficiently can be achieved by using distributed irrigation control (DIC, which has the advantages of reduced wiring and piping costs and easier installation and maintenance. In this study, a wireless low power valve controller for drip irrigation control systems was developed and tested. The specific tasks included the controller design (hardware and software, energy consumption tests, and field tests. The controller uses the highly integrated JN5139 module, which is based on IEEE802.15.4, for hardware design; low power consumption sleep algorithms for software design; and two alkaline batteries for supply of power to the valve controller. Results of laboratory and field tests show continuous working days of the valve controller powered by two alkaline batteries are at least 3 months under different sleep periods and frequencies of valve control. The controller described here is characterized as reliable, low cost, easy to install, and having low power consumption.
Control switching in high performance and fault tolerant control

DEFF Research Database (Denmark)

Niemann, Hans Henrik; Poulsen, Niels Kjølstad

2010-01-01

The problem of reliability in high performance control and in fault tolerant control is considered in this paper. A feedback controller architecture for high performance and fault tolerance is considered. The architecture is based on the Youla-Jabr-Bongiorno-Kucera (YJBK) parameterization. By usi...
Controller for computer control of brushless dc motors. [automobile engines

Science.gov (United States)

Hieda, L. S. (Inventor)

1981-01-01

A motor speed and torque controller for brushless d.c. motors provides an unusually smooth torque control arrangement. The controller provides a means for controlling a current waveform in each winding of a brushless dc motor by synchronization of an excitation pulse train from a programmable oscillator. Sensing of torque for synchronization is provided by a light beam chopper mounted on the motor rotor shaft. Speed and duty cycle are independently controlled by controlling the frequency and pulse width output of the programmable oscillator. A means is also provided so that current transitions from one motor winding to another is effected without abrupt changes in output torque.
Control room design

International Nuclear Information System (INIS)

Zinke, H.

1980-01-01

To control a 1300 megawatt nuclear power plant, about 15000 plant parameters must be collected together to control and operate the plant. The control room design therefore is of particular importance. The main design criteria are: Required functions of the power plant process - Level of Automation - Ergonomics - Available Technology. Extensive analysis has resulted in a control room design method. This ensures that an objective solution will be reached. Resulting from this methodical approach are: 1. Scope, position and appearance of the instrumentation. 2. Scope, position and appearance of the operator controls. Process analysis dictates what instrumentation and operator controls are needed. The priority and importance of the control and instrumentation (this we define as the utilisation areas), dictates the rough layout of the control room. (orig./RW)
Fault diagnosis and fault-tolerant control based on adaptive control approach

CERN Document Server

Shen, Qikun; Shi, Peng

2017-01-01

This book provides recent theoretical developments in and practical applications of fault diagnosis and fault tolerant control for complex dynamical systems, including uncertain systems, linear and nonlinear systems. Combining adaptive control technique with other control methodologies, it investigates the problems of fault diagnosis and fault tolerant control for uncertain dynamic systems with or without time delay. As such, the book provides readers a solid understanding of fault diagnosis and fault tolerant control based on adaptive control technology. Given its depth and breadth, it is well suited for undergraduate and graduate courses on linear system theory, nonlinear system theory, fault diagnosis and fault tolerant control techniques. Further, it can be used as a reference source for academic research on fault diagnosis and fault tolerant control, and for postgraduates in the field of control theory and engineering. .
Controlling chaos in Internet congestion control model

Energy Technology Data Exchange (ETDEWEB)

Chen Liang E-mail: chenmoon110@yahoo.com.cn; Wang Xiaofan; Han Zhengzhi

2004-07-01

The TCP end-to-end congestion control plus RED router queue management can be modeled as a discrete-time dynamical system, which may create complex bifurcating and chaotic behavior. Based on the basic features of the TCP-RED model, we propose a time-dependent delayed feedback control algorithm to control chaos in the system by perturbing the accessible RED parameter p{sub max}. This method is able to stabilized a router queue occupancy at a level without knowing the exact knowledge of the network. Further, we study the situation of the presence of the UDP traffic.
Control cards as a statistical quality control resource

Directory of Open Access Journals (Sweden)

Aleksandar Živan Drenovac

2013-02-01

Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 This paper proves that applying of statistical methods can significantly contribute increasing of products and services quality, as well as increasing of institutions rating. Determining of optimal, apropos anticipatory and limitary values, is based on sample`s statistical analyze. Control cards represent very confident instrument, which is simple for use and efficient for control of process, by which process is maintained in set borders. Thus, control cards can be applied in quality control of procesess of weapons and military equipment production, maintenance of technical systems, as well as for seting of standards and increasing of quality level for many other activities.
Determination Of Adaptive Control Parameter Using Fuzzy Logic Controller

Directory of Open Access Journals (Sweden)

Omur Can Ozguney

2017-08-01

Full Text Available The robot industry has developed along with the increasing the use of robots in industry. This has led to increase the studies on robots. The most important part of these studies is that the robots must be work with minimum tracking trajectory error. But it is not easy for robots to track the desired trajectory because of the external disturbances and parametric uncertainty. Therefore adaptive and robust controllers are used to decrease tracking error. The aim of this study is to increase the tracking performance of the robot and minimize the trajectory tracking error. For this purpose adaptive control law for robot manipulator is identified and fuzzy logic controller is applied to find the accurate values for adaptive control parameter. Based on the Lyapunov theory stability of the uncertain system is guaranteed. In this study robot parameters are assumed to be unknown. This controller is applied to a robot model and the results of simulations are given. Controller with fuzzy logic and without fuzzy logic are compared with each other. Simulation results show that the fuzzy logic controller has improved the results.
Relative controllability and null controllability of linear delay systems ...

African Journals Online (AJOL)

Necessary and sufficient conditions are established for the relative, absolute controllability and null controllability of the generalized linear delay system and its discrete prototype. The paper presents illuminating examples on previous controllability results by Manitius and Olbrot [7] and carries over the results of Onwuatu [8] ...
Noninteracting control of nonlinear systems based on relaxed control

NARCIS (Netherlands)

Jayawardhana, B.

2010-01-01

In this paper, we propose methodology to solve noninteracting control problem for general nonlinear systems based on the relaxed control technique proposed by Artstein. For a class of nonlinear systems which cannot be stabilized by smooth feedback, a state-feedback relaxed control can be designed to

Robust position control of induction motor using fuzzy logic control

International Nuclear Information System (INIS)

Kim, Sei Chan; Kim, Duk Hun; Yang, Seung Ho; Won, Chung Yuen

1993-01-01

In recent years, fuzzy logic or fuzzy set theory has reveived attention of a number of researchers in the area of power electronics and motion control. The paper describes a vector-controlled induction motor position servo drive where fuzzy control is used to get robustness against parameter variation and load torque disturbance effects. Both coarse and fine control with the help of look-up rule tables are used to improve transient response and system settling time. The performance characteristics are then compared with those of proportional-integral(PI) control. The simulation results clearly indicate the superiority of fuzzy control with larger number of rules. The fuzzy controller was implemented with a 16-bit microprocessor and tested in laboratory on a 3-hp IGBT inverter induction motor drive system. The test results verify the simulation performance. (Author)
Nonlinear control strategy based on using a shape-tunable neural controller

Energy Technology Data Exchange (ETDEWEB)

Chen, C.; Peng, S. [Feng Chia Univ, Taichung (Taiwan, Province of China). Department of chemical Engineering; Chang, W. [Feng Chia Univ, Taichung (Taiwan, Province of China). Department of Automatic Control

1997-08-01

In this paper, a nonlinear control strategy based on using a shape-tunable neural network is developed for adaptive control of nonlinear processes. Based on the steepest descent method, a learning algorithm that enables the neural controller to possess the ability of automatic controller output range adjustment is derived. The novel feature of automatic output range adjustment provides the neural controller more flexibility and capability, and therefore the scaling procedure, which is usually unavoidable for the conventional fixed-shape neural controllers, becomes unnecessary. The advantages and effectiveness of the proposed nonlinear control strategy are demonstrated through the challenge problem of controlling an open-loop unstable nonlinear continuous stirred tank reactor (CSTR). 14 refs., 11 figs.
Design of Multi Objectives Control Systems to Control Nuclear Reactor Power

International Nuclear Information System (INIS)

Abdelaal, M.M.Z.

2013-01-01

The Egyptian Testing Research Reactor (ETRR-2) nonlinear twelfth order model is linearized and reduced to lower order model. Model order reduction methodologies such as balanced truncation, Schur reduction method, Hankel approximation and Coprime factorization have been used in the reduction process. The reactor actually controlled by PD controller with fixed tuning parameters. LMI state feedback, LMI-pool assignment, H ∞ and observer based controllers based third order model are proposed to be used in the reactor power control instead of the PD controller. A comparison of LMI, LMI-Pole placement,H ∞ control systems and those of based observer relative to the PD controller has been performed which showed better response and disturbance rejection for the proposed controllers.
An accurate reactive power control study in virtual flux droop control

Science.gov (United States)

Wang, Aimeng; Zhang, Jia

2017-12-01

This paper investigates the problem of reactive power sharing based on virtual flux droop method. Firstly, flux droop control method is derived, where complicated multiple feedback loops and parameter regulation are avoided. Then, the reasons for inaccurate reactive power sharing are theoretically analyzed. Further, a novel reactive power control scheme is proposed which consists of three parts: compensation control, voltage recovery control and flux droop control. Finally, the proposed reactive power control strategy is verified in a simplified microgrid model with two parallel DGs. The simulation results show that the proposed control scheme can achieve accurate reactive power sharing and zero deviation of voltage. Meanwhile, it has some advantages of simple control and excellent dynamic and static performance.
Process and apparatus for controlling control rods

International Nuclear Information System (INIS)

Gebelin, B.; Couture, R.

1987-01-01

This process and apparatus is characterized by 2 methods, for examination of cluster of nuclear control rods. Foucault current analyzer which examines fraction by fraction all the control rods. This examination is made by rotation of the cluster. Doubtful rods are then analysed by ultrasonic probe [fr
Predictive IP controller for robust position control of linear servo system.

Science.gov (United States)

Lu, Shaowu; Zhou, Fengxing; Ma, Yajie; Tang, Xiaoqi

2016-07-01

Position control is a typical application of linear servo system. In this paper, to reduce the system overshoot, an integral plus proportional (IP) controller is used in the position control implementation. To further improve the control performance, a gain-tuning IP controller based on a generalized predictive control (GPC) law is proposed. Firstly, to represent the dynamics of the position loop, a second-order linear model is used and its model parameters are estimated on-line by using a recursive least squares method. Secondly, based on the GPC law, an optimal control sequence is obtained by using receding horizon, then directly supplies the IP controller with the corresponding control parameters in the real operations. Finally, simulation and experimental results are presented to show the efficiency of proposed scheme. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.
Relationship between antigravity control and postural control in young children.

Science.gov (United States)

Sellers, J S

1988-04-01

The purposes of this study were 1) to determine the relationship between antigravity control (supine flexion and prone extension) and postural control (static and dynamic balance), 2) to determine the quality of antigravity and postural control, and 3) to determine whether sex and ethnic group differences correlate with differences in antigravity control and postural control in young children. I tested 107 black, Hispanic, and Caucasian children in a Head Start program, with a mean age of 61 months. The study results showed significant relationships between antigravity control and postural control. Subjects' supine flexion performance was significantly related to the quantity and quality of their static and dynamic balance performance, whereas prone extension performance was related only to the quality of dynamic balance performance. Quality scale measurements (r = .90) indicated that the children in this study had not yet developed full antigravity or postural control. The study results revealed differences between sexes in the quality of static balance and prone extension performance and ethnic differences in static balance, dynamic balance, and prone extension performance.
A modelling and control structure for product quality control in climate-controlled processing of agro-material

NARCIS (Netherlands)

Verdijck, G.J.C.; Straten, van G.

2002-01-01

In this paper a modelling and control structure for product quality control is presented for a class of operations that processes agro-material. This class can be characterised as climate-controlled operations, such as storage, transport and drying. The basic model consists of three parts. These are
Integrated Biological Control

International Nuclear Information System (INIS)

JOHNSON, A.R.

2002-01-01

Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects; and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (apriori) or in response to existing contamination spread (aposteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and apriori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, aposteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response
Strike Point Control on EAST Using an Isoflux Control Method

International Nuclear Information System (INIS)

Xing Zhe; Xiao Bingjia; Luo Zhengping; Walker, M. L.; Humphreys, D. A.

2015-01-01

For the advanced tokamak, the particle deposition and thermal load on the divertor is a big challenge. By moving the strike points on divertor target plates, the position of particle deposition and thermal load can be shifted. We could adjust the Poloidal Field (PF) coil current to achieve the strike point position feedback control. Using isoflux control method, the strike point position can be controlled by controlling the X point position. On the basis of experimental data, we establish relational expressions between X point position and strike point position. Benchmark experiments are carried out to validate the correctness and robustness of the control methods. The strike point position is successfully controlled following our command in the EAST operation. (paper)
Development and comparison of integrated dynamics control systems with fuzzy logic control and sliding mode control

International Nuclear Information System (INIS)

Song, Jeong Hoon

2013-01-01

In this study, four integrated dynamics control (IDC) systems abbreviated as IDCB, IDCS, IDCF, and IDCR are developed, evaluated and compared. IDC systems were integrated with brake and steer control systems to enhance lateral stability and handling performance. To construct the IDC systems, a vehicle model with fourteen degrees of freedom, a fuzzy logic controller, and a sliding mode ABS controller were used. They were tested with various steering inputs when excessive full brake pressure or no brake pressure was applied on dry asphalt, wet asphalt, a snow-covered paved road, and a split-µ road. The results showed that an IDC-equipped vehicle improved lateral stability and controllability in every driving condition compared to an ABS-equipped vehicle. Under all road conditions, IDC controllers enabled the yaw rate to follow the reference yaw rate almost perfectly and reduced the body slip angle. On a split-µ road, IDCB, IDCS, IDCF, and IDCR vehicles drove straight ahead with only very small deviations.
Fault Tolerant Control Using Gaussian Processes and Model Predictive Control

Directory of Open Access Journals (Sweden)

Yang Xiaoke

2015-03-01

Full Text Available Essential ingredients for fault-tolerant control are the ability to represent system behaviour following the occurrence of a fault, and the ability to exploit this representation for deciding control actions. Gaussian processes seem to be very promising candidates for the first of these, and model predictive control has a proven capability for the second. We therefore propose to use the two together to obtain fault-tolerant control functionality. Our proposal is illustrated by several reasonably realistic examples drawn from flight control.
A nuclear reactor power controller using a receding horizon control method

International Nuclear Information System (INIS)

Na, Man Gyun; Sim, Young Rok

2001-01-01

A receding horizon control method is applied to design a fully automatic controller for thermal power in a reactor core. The basic concept of the receding horizon control is to solve an optimization problem for a finite future at current time and to implement as the current control input the first optimal control input among the solutions of the finite time steps. The procedure is then repeated at each subsequent instant. The receding horizon controller is designed so that the difference between the output and the desired output is minimized and the variation of the control rod position is small. The nonlinear PWR plant model (nonlinear point kinetics equation with six delayed neutron groups and the lumped thermal-hydraulic balance equations) was used to verify the proposed controller of reactor power. And a controller design model used for designing the receding horizon controller was obtained by applying a parameter estimation algorithm. From numerical simulation results, the performances of this controller for the 5%/min ramp increase or decrease of a desired load and its 10% step increase or decrease which are design requirements are proved to be excellent
Adaptive control method for core power control in TRIGA Mark II reactor

Science.gov (United States)

Sabri Minhat, Mohd; Selamat, Hazlina; Subha, Nurul Adilla Mohd

2018-01-01

The 1MWth Reactor TRIGA PUSPATI (RTP) Mark II type has undergone more than 35 years of operation. The existing core power control uses feedback control algorithm (FCA). It is challenging to keep the core power stable at the desired value within acceptable error bands to meet the safety demand of RTP due to the sensitivity of nuclear research reactor operation. Currently, the system is not satisfied with power tracking performance and can be improved. Therefore, a new design core power control is very important to improve the current performance in tracking and regulate reactor power by control the movement of control rods. In this paper, the adaptive controller and focus on Model Reference Adaptive Control (MRAC) and Self-Tuning Control (STC) were applied to the control of the core power. The model for core power control was based on mathematical models of the reactor core, adaptive controller model, and control rods selection programming. The mathematical models of the reactor core were based on point kinetics model, thermal hydraulic models, and reactivity models. The adaptive control model was presented using Lyapunov method to ensure stable close loop system and STC Generalised Minimum Variance (GMV) Controller was not necessary to know the exact plant transfer function in designing the core power control. The performance between proposed adaptive control and FCA will be compared via computer simulation and analysed the simulation results manifest the effectiveness and the good performance of the proposed control method for core power control.
BSF control system

International Nuclear Information System (INIS)

Irie, Y.; Ishii, K.; Ninomiya, S.; Sasaki, H.; Sakai, I.

1982-08-01

The booster synchrotron utilization facility (BSF) is a facility which utilizes the four fifths of available beam pulses from the KEK booster synchrotron. The BSF control system includes the beam line control, interactions with the PS central control room and the experimental facilities, and the access control system. A brief description of the various components in the control system is given. (author)
Does Self-Control Training Improve Self-Control? A Meta-Analysis.

Science.gov (United States)

Friese, Malte; Frankenbach, Julius; Job, Veronika; Loschelder, David D

2017-11-01

Self-control is positively associated with a host of beneficial outcomes. Therefore, psychological interventions that reliably improve self-control are of great societal value. A prominent idea suggests that training self-control by repeatedly overriding dominant responses should lead to broad improvements in self-control over time. Here, we conducted a random-effects meta-analysis based on robust variance estimation of the published and unpublished literature on self-control training effects. Results based on 33 studies and 158 effect sizes revealed a small-to-medium effect of g = 0.30, confidence interval (CI 95 ) [0.17, 0.42]. Moderator analyses found that training effects tended to be larger for (a) self-control stamina rather than strength, (b) studies with inactive compared to active control groups, (c) males than females, and (d) when proponents of the strength model of self-control were (co)authors of a study. Bias-correction techniques suggested the presence of small-study effects and/or publication bias and arrived at smaller effect size estimates (range: g corrected = .13 to .24). The mechanisms underlying the effect are poorly understood. There is not enough evidence to conclude that the repeated control of dominant responses is the critical element driving training effects.
Transition from natural-convection-controlled freezing to conduction-controlled freezing

International Nuclear Information System (INIS)

Sparrow, E.M.; Ramsey, J.W.; Harris, J.S.

1981-01-01

Experiments were performed to study the transition between freezing controlled by natural convection in the liquid adjacent to a freezing interface and freezing controlled by heat conduction in the solidified material. The freezing took place on a cooled vertical tube immersed in an initially superheated liquid contained in an adiabatic-walled vessel. At early and intermediate times, temperature differences throughout the liquid induce a vigorous natural convection motion which retards freezing, but the temperature differences diminish with time and natural convection ebbs. At large times, the freezing rate is fully controlled by heat conduction in the solidified material. The frozen specimens for short and intermediate freezing times are smooth-surfaced and tapered, while those for large times are straight-sided and have surfaces that are overlaid with a thicket of large discrete crystals. These characteristics correspond respectively to those of natural-convection- controlled freezing and conduction-controlled freezing. At early times, the measured mass of the frozen material is identical to that for natural-convection-controlled freezing and conduction-controlled freezing. At early times, the measured mass of the frozen material is identical to that for natural-convection-controlled freezing. At later times, the frozen mass tends to approach that for conduction-controlled freezing, but a residual deficit remains
A fast PID controller Design for Modern PLC for Process Control Application

International Nuclear Information System (INIS)

Mirza, A.; Nafis, A.; Anees, R.M.; Idris, S.

2004-01-01

PID is the most widely used control scheme in the process industry. Pill controllers are utilized for the control of such varied parameters as pressure, flow, temperature, etc. One characteristic of these parameters is that they posses slow dynamics. Most of the available digital controllers can manipulate only a single parameter- multiple controllers are required for control of more than one parameter. The Fast PID Controller for Modem PLC (Programmable Logic Controller) developed by the authors, provides control of several parameters at a time (through a single Pill control element), enhanced programmability including variable sampling period, parameter monitoring and data storage, which may be easily implemented in a PLC. (author)
Design of fuzzy learning control systems for steam generator water level control

International Nuclear Information System (INIS)

Park, Gee Yong

1996-02-01

A fuzzy learning algorithm is developed in order to construct the useful control rules and tune the membership functions in the fuzzy logic controller used for water level control of nuclear steam generator. The fuzzy logic controllers have shown to perform better than conventional controllers for ill-defined or complex processes such as nuclear steam generator. Whereas the fuzzy logic controller does not need a detailed mathematical model of a plant to be controlled, its structure is to be made on the basis of the operator's linguistic information experienced from the plant operations. It is not an easy work and also there is no systematic way to translate the operator's linguistic information into quantitative information. When the linguistic information of operators is incomplete, tuning the parameters of fuzzy controller is to be performed for better control performance. It is the time and effort consuming procedure that controller designer has to tune the structure of fuzzy logic controller for optimal performance. And if the number of control inputs is many and the rule base is constructed in multidimensional space, it is very difficult for a controller designer to tune the fuzzy controller structure. Hence, the difficulty in putting the experimental knowledge into quantitative (or numerical) data and the difficulty in tuning the rules are the major problems in designing fuzzy logic controller. In order to overcome the problems described above, a learning algorithm by gradient descent method is included in the fuzzy control system such that the membership functions are tuned and the necessary rules are created automatically for good control performance. For stable learning in gradient descent method, the optimal range of learning coefficient not to be trapped and not to provide too slow learning speed is investigated. With the optimal range of learning coefficient, the optimal value of learning coefficient is suggested and with this value, the gradient
Good control practices underlined by an on-line fuzzy control database

Directory of Open Access Journals (Sweden)

Alonso, M. V.

1994-04-01

Full Text Available In the olive oil trade, control systems that automate extraction processes, cutting production costs and increasing processing capacity without losing quality, are always desirable. The database structure of an on-line fuzzy control of centrifugation systems and the algorithms used to attain the best control conditions are analysed. Good control practices are suggested to obtain virgin olive oil of prime quality.

In the olive oil trade, control systems that automate extraction processes, cutting production costs and increasing processing capacity without losing quality, are always desirable. The database structure of an on-line fuzzy control of centrifugation systems and the algorithms used to attain the best control conditions are analysed. Good control practices are suggested to obtain virgin olive oil of prime quality.

Simulation Analysis of Computer-Controlled pressurization for Mixture Ratio Control

Science.gov (United States)

Alexander, Leslie A.; Bishop-Behel, Karen; Benfield, Michael P. J.; Kelley, Anthony; Woodcock, Gordon R.

2005-01-01

A procedural code (C++) simulation was developed to investigate potentials for mixture ratio control of pressure-fed spacecraft rocket propulsion systems by measuring propellant flows, tank liquid quantities, or both, and using feedback from these measurements to adjust propellant tank pressures to set the correct operating mixture ratio for minimum propellant residuals. The pressurization system eliminated mechanical regulators in favor of a computer-controlled, servo- driven throttling valve. We found that a quasi-steady state simulation (pressure and flow transients in the pressurization systems resulting from changes in flow control valve position are ignored) is adequate for this purpose. Monte-Carlo methods are used to obtain simulated statistics on propellant depletion. Mixture ratio control algorithms based on proportional-integral-differential (PID) controller methods were developed. These algorithms actually set target tank pressures; the tank pressures are controlled by another PID controller. Simulation indicates this approach can provide reductions in residual propellants.
Efficacy of internal control and controlling business risks

Directory of Open Access Journals (Sweden)

Luminiţa IONESCU

2010-06-01

Full Text Available Companies can gain additional efficiency in designing and implementing or assessing internal control by focusing on only those financial reporting objectives directly applicable to the company’s activities and circumstances, taking a risk based approach to internal control. It is important for any organization to have reliable financial data for internal decision-making purpose. Financial information is often useful in many internal decisions such as product or service pricing. This is why the most important function of the controller is to create and maintain the corporate financial control system. Today’s corporation operates in an increasingly complex environment and the controller’s role is to advice the management of current or future problems of the business environment or to prevent the fraud.
Heat control in HVDC resistive divider by PID and NN controllers

International Nuclear Information System (INIS)

Yilmaz, S.; Dincer, H.; Eksin, I.; Kalenderli, O.

2007-01-01

In this study, a control system is presented that is devised to increase measurement precisions within a prototype high voltage DC resistive divider (HVDC-RD). Since one of the major sources of measurement errors in such devices is the self heating effect, a system controlling the temperature within the high voltage DC resistive divider is devised so that suitable and stable temperature conditions are maintained that, in return, will decrease the measurement errors. The resistive divider system is cooled by oil, and PID and neural network (NN) controllers try to keep the temperature within the prescribed limits. The system to be controlled exhibits a nonlinear character, and therefore, a control approach based on NN controllers is proposed. Thus, a system that can fulfill the various requirements dictated by the designer is constructed. The performance of the NN controller is compared with that of the PID controller developed for the same purpose, and the values of the performance indices indicate the superiority of the NN controller over that of the classical PID controller
Modernization of control system using the digital control system

International Nuclear Information System (INIS)

Carrasco, J. A.; Fernandez, L.; Jimenez, A.

2002-01-01

Nowadays, all plant automation tendencies are based on the use of Digital Control System. In big industrial plants the control systems employed are Distributed Control Systems (DCS). The addition of these systems in nuclear power plants,implies an important adaptation process, because most of them were installed using analog control systems. This paper presents the objectives and the first results obtained, in a modernization project, focused in obtaining an engineering platform for making test and analysis of changes prior to their implementation in a nuclear plant. Modernization, Upgrade, DCS, Automation, Simulation, Training. (Author)
Robust tracking control of uncertain Duffing-Holmes control systems

International Nuclear Information System (INIS)

Sun, Y.-J.

2009-01-01

In this paper, the notion of virtual stabilizability for dynamical systems is introduced and the virtual stabilizability of uncertain Duffing-Holmes control systems is investigated. Based on the time-domain approach with differential inequality, a tracking control is proposed such that the states of uncertain Duffing-Holmes control system track the desired trajectories with any pre-specified exponential decay rate and convergence radius. Moreover, we present an algorithm to find such a tracking control. Finally, a numerical example is provided to illustrate the use of the main results.
A CAMAC based knob controller for the LAMPF control system

International Nuclear Information System (INIS)

Smith, W.; Bjorklund, E.

1987-01-01

The control computer for the Los Alamos Meson Physics Facility (LAMPF) has been recently upgraded from an SEL-840 to a VAX 11/780 running the VMS operating system. As part of this upgrade, a CAMAC-based knob controller was developed for the new control system. The knobs allow the facility operators to have slew control over software selectable accelerator devices. An alphanumeric display associated with each knob monitors the progress of the selected device. This paper describes the system requirements for the new LAMPF knob controller, and the resulting hardware and software design
Trust and controlling

Directory of Open Access Journals (Sweden)

Bieńkowska Agnieszka

2016-12-01

Full Text Available The purpose of this study is to discuss the trust within and towards an organisation in the context of implementation of controlling therein. In this context the essence of trust and its importance in organisation management was presented, as well as trust in the contemporary management methods and concepts. Controlling as a trust-building factor inside an organisation was pointed out. Especially controlling and control were described. Moreover management by considering deviations in controlling and the teamwork in controlling were described. The role of controlling in process of trust-building to an organisation was presented. Establishing relations with the environment and systems of measurement of organisation’s achievements were presented, too.
Control of SMES

International Nuclear Information System (INIS)

Murakami, Y.; Sugita, M.; Kiuchi, T.; Okuda, H.

1981-01-01

The use of a thyristor Graetz bridge as the interface between the 3-phase ac source and the superconducting magnet (SM) has become standard in superconducting magnetic energy storage (SMES). In the future, the bridge will be DDC (direct digital control) controlled by microprocessors and the higher computations, such as the strategy for economical operation of the SMES plant will be computed by a large-scale computer resulting in a hierarchical control scheme. Some of the problems of DDC control of a SM are discussed, control schemes for effective and reactive power are compared, and the control system for the sequential control of a 0.5 MJ pulsed magnet, which is under construction, is described
Programmable Digital Controller

Science.gov (United States)

Wassick, Gregory J.

2012-01-01

An existing three-channel analog servo loop controller has been redesigned for piezoelectric-transducer-based (PZT-based) etalon control applications to a digital servo loop controller. This change offers several improvements over the previous analog controller, including software control over proportional-integral-derivative (PID) parameters, inclusion of other data of interest such as temperature and pressure in the control laws, improved ability to compensate for PZT hysteresis and mechanical mount fluctuations, ability to provide pre-programmed scanning and stepping routines, improved user interface, expanded data acquisition, and reduced size, weight, and power.
Control of a deareador level of a thermoelectric power station using modern control techniques; Control de nivel de un deareador de una central termoelectrica utilizando tecnicas de control moderno

Energy Technology Data Exchange (ETDEWEB)

Chavez Estrada, Jose Israel

1997-01-01

The present work shows the implementation of the scheme of predictive control IMC (Internal Model Control) in order to control the level of the deareador of a combined cycle thermoelectric power station of (C.C.T.S.). The implementation has the purpose of looking for alternative strategies of control to the classic ones (PID`s) that more efficiently control the variables of interest, in addition to getting into the new control techniques of control. Following the philosophy of predictive control IMC the form to applying this technique is shown, as well as the implementation of this type of controllers. A comparison of predictive control IMC is made with the scheme of conventional control (three control elements PID`s ) used at present to control the level of the deareador in the Combined Cycle Thermoelectric Power stations of Dos Bocas, Veracruz, Mexico and of Gomez Palacio, Durango, Mexico. [Espanol] El presente trabajo muestra la implementacion del esquema de control predictivo IMC (Control con Modelo Interno) con el objeto de controlar el nivel del deareador de una Central Termoelectrica de Ciclo Combinado (C.T.C.C.). La implementacion tiene la finalidad de buscar estrategias de control alternas a las clasicas (PID`s) que controlen mas eficientemente la variable de interes, ademas de incursionar en las nuevas tecnicas de control. Siguiendo la filosofia del control predictivo IMC se muestra la forma de aplicar esta tecnica, asi como la implementacion de este tipo de controladores. Se hace una comparacion del control predictivo IMC con el esquema de control convencional (control de tres elementos PID`s) utilizando actualmente para controlar el nivel del deareador en las centrales termoelectricas de ciclo combinado de Dos Bocas, Veracruz y de Gomez Palacio, Durango en Mexico.
Pneumatic control technology

International Nuclear Information System (INIS)

Tae, Seong Gil; Kim, Won Hoe; Nam, Dae Hyun

1993-03-01

This book contains property of pneumatic pressure drive, pneumatic pressure device like air cleaning, pressure control, lubricators, air pressure pipe, kinds and function of pneumatic pressure equipment like pneumatic cylinders, pneumatic motor, flow control valve, direction control valve, design of pneumatic control circuit, pneumatic system design, cause and measurement of pneumatic circuit failure, PLC and pneumatic control like introduction and system application and method of PLC programing.
Accounting for control mislabeling in case-control biomarker studies.

Science.gov (United States)

Rantalainen, Mattias; Holmes, Chris C

2011-12-02

In biomarker discovery studies, uncertainty associated with case and control labels is often overlooked. By omitting to take into account label uncertainty, model parameters and the predictive risk can become biased, sometimes severely. The most common situation is when the control set contains an unknown number of undiagnosed, or future, cases. This has a marked impact in situations where the model needs to be well-calibrated, e.g., when the prediction performance of a biomarker panel is evaluated. Failing to account for class label uncertainty may lead to underestimation of classification performance and bias in parameter estimates. This can further impact on meta-analysis for combining evidence from multiple studies. Using a simulation study, we outline how conventional statistical models can be modified to address class label uncertainty leading to well-calibrated prediction performance estimates and reduced bias in meta-analysis. We focus on the problem of mislabeled control subjects in case-control studies, i.e., when some of the control subjects are undiagnosed cases, although the procedures we report are generic. The uncertainty in control status is a particular situation common in biomarker discovery studies in the context of genomic and molecular epidemiology, where control subjects are commonly sampled from the general population with an established expected disease incidence rate.
Robust control charts in statistical process control

NARCIS (Netherlands)

Nazir, H.Z.

2014-01-01

The presence of outliers and contaminations in the output of the process highly affects the performance of the design structures of commonly used control charts and hence makes them of less practical use. One of the solutions to deal with this problem is to use control charts which are robust
Disturbance observer based current controller for vector controlled IM drives

DEFF Research Database (Denmark)

Teodorescu, Remus; Dal, Mehmet

2008-01-01

induction motor (IM) drives. The control design, based on synchronously rotating d-q frame model of the machine, has a simple structure that combines the proportional portion of a conventional PI control and output of the observer. The observer is predicted to estimate the disturbances caused by parameters...... coupling effects and increase robustness against parameters change without requiring any other compensation strategies. The experimental implementation results are provided to demonstrate validity and performance of the proposed control scheme.......In order to increase the accuracy of the current control loop, usually, well known parameter compensation and/or cross decoupling techniques are employed for advanced ac drives. In this paper, instead of using these techniques an observer-based current controller is proposed for vector controlled...
High-Precision Control of a Piezo-Driven Nanopositioner Using Fuzzy Logic Controllers

Directory of Open Access Journals (Sweden)

Mohammed Altaher

2018-01-01

Full Text Available This paper presents single- and dual-loop fuzzy control schemes to precisely control the piezo-driven nanopositioner in the x- and y-axis directions. Various issues are associated with this control problem, such as low stability margin due to the sharp resonant peak, nonlinear dynamics, parameter uncertainty, etc. As such, damping controllers are often utilised to damp the mechanical resonance of the nanopositioners. The Integral Resonant Controller (IRC is used in this paper as a damping controller to damp the mechanical resonance. A further inherent problem is the hysteresis phenomenon (disturbance, which leads to degrading the positioning performance (accuracy of the piezo-driven stage. The common approach to treat this disturbance is to invoke tracking controllers in a closed-loop feedback scheme in conjunction with the damping controllers. The traditional approach uses the Integral Controller (I or Proportional Integral (PI as a tracking controller, whereas this paper introduces the Proportional and Integral (PI-like Fuzzy Logic Controller (FLC as a tracking controller. The effectiveness of the proposed control schemes over conventional schemes is confirmed through comparative simulation studies, and results are presented. The stability boundaries of the proposed control schemes are determined in the same way as with a conventional controller. Robustness against variations in the resonant frequency of the proposed control schemes is verified.
Spacecraft attitude control using neuro-fuzzy approximation of the optimal controllers

Science.gov (United States)

Kim, Sung-Woo; Park, Sang-Young; Park, Chandeok

2016-01-01

In this study, a neuro-fuzzy controller (NFC) was developed for spacecraft attitude control to mitigate large computational load of the state-dependent Riccati equation (SDRE) controller. The NFC was developed by training a neuro-fuzzy network to approximate the SDRE controller. The stability of the NFC was numerically verified using a Lyapunov-based method, and the performance of the controller was analyzed in terms of approximation ability, steady-state error, cost, and execution time. The simulations and test results indicate that the developed NFC efficiently approximates the SDRE controller, with asymptotic stability in a bounded region of angular velocity encompassing the operational range of rapid-attitude maneuvers. In addition, it was shown that an approximated optimal feedback controller can be designed successfully through neuro-fuzzy approximation of the optimal open-loop controller.
Induction machine Direct Torque Control system based on fuzzy adaptive control

Science.gov (United States)

Li, Shi-ping; Yu, Yan; Jiao, Zhen-gang; Gu, Shu-sheng

2009-07-01

Direct Torque Control technology is a high-performance communication control method, it uses the space voltage vector method, and then to the inverter switch state control, to obtain high torque dynamic performance. But none of the switching states is able to generate the exact voltage vector to produce the desired changes in torque and flux in most of the switching instances. This causes a high ripple in torque. To solve this problem, a fuzzy implementation of Direct Torque Control of Induction machine is presented here. Error of stator flux, error of motor electromagnetic torque and position of angle of flux are taken as fuzzy variables. In order to further solve nonlinear problem of variation parameters in direct torque control system, the paper proposes a fuzzy parameter PID adaptive control method which is suitable for the direct torque control of an asynchronous motor. The generation of its fuzzy control is obtained by analyzing and optimizing PID control step response and combining expert's experience. For this reason, it carries out fuzzy work to PID regulator of motor speed to achieve to regulate PID parameters. Therefore the control system gets swifter response velocity, stronger robustness and higher precision of velocity control. The computer simulated results verify the validity of this novel method.
Reactor control device

International Nuclear Information System (INIS)

Araki, Takao; Inoue, Toyokazu.

1981-01-01

Purpose: To protect the reactor floor by alleviating the shock imparted to the reactor floor by a dropped control rod when a wire rope accidentally breaks. Constitution: A control rod is hung by wire rope from a control rod drive, and shock absorbers are mounted at the upper and lower portions of the control rod. The outer diameter of the upper shock absorber is made larger than the inner diameter of a control rod inserting hole formed in the reactor core. If the control rod drops, the upper absorber is stopped at the upper tapered portion of the inserting hole. Thus, the dropping energy of the control rod can be sufficiently absorbed by the upper and lower shock absorbers. (Kamimura, M.)
An adaptive neuro-fuzzy controller for mold level control in continuous casting

International Nuclear Information System (INIS)

Zolghadri Jahromi, M.; Abolhassan Tash, F.

2001-01-01

Mold variations in continuous casting are believed to be the main cause of surface defects in the final product. Although a Pid controller is well capable of controlling the level under normal conditions, it cannot prevent large variations of mold level when a disturbance occurs in the form of nozzle unclogging. In this paper, dual controller architecture is presented, a Pid controller is used as the main controller of the plant and an adaptive neuro-fuzzy controller is used as an auxiliary controller to help the Pid during disturbed phases. The control is passed back to the Pid controller after the disturbance is being dealt with. Simulation results prove the effectiveness of this control strategy in reducing mold level variations during the unclogging period
A Robust Practical Generalized Predictive Control for BoilerSuper Heater Temperature Control

OpenAIRE

Zaki Maki Mohialdeen

2015-01-01

A practical method of robust generalized predictive controller (GPC) application is developed using a combination of Ziegler-Nichols type functions relating the GPC controller parameters to a first order with time delay process parameters and a model matching controller. The GPC controller and the model matching controller are used in a master/slave configuration, with the GPC as the master controller and the model matching controller as the slave controlle...

Switching Fuzzy Guaranteed Cost Control for Nonlinear Networked Control Systems

Directory of Open Access Journals (Sweden)

Linqin Cai

2014-01-01

Full Text Available This paper deals with the problem of guaranteed cost control for a class of nonlinear networked control systems (NCSs with time-varying delay. A guaranteed cost controller design method is proposed to achieve the desired control performance based on the switched T-S fuzzy model. The switching mechanism is introduced to handle the uncertainties of NCSs. Based on Lyapunov functional approach, some sufficient conditions for the existence of state feedback robust guaranteed cost controller are presented. Simulation results show that the proposed method is effective to guarantee system’s global asymptotic stability and quality of service (QoS.
Stability, Power Sharing, & Distributed Secondary Control in Droop-Controlled Microgrids

DEFF Research Database (Denmark)

Simpson-Porco, John; Dorfler, Florian; Bullo, Francesco

2013-01-01

Motivated by the recent and growing interest in microgrids, we study the operation of droop-controlled DC/AC inverters in an islanded inductive microgrid. We present a necessary and sufficient condition for the existence of a synchronized steady state that is unique and locally exponentially stable....... We discuss a selection of controller gains which leads to a sharing of power among the generators, and show that this proportional selection enforces actuation constraints for the inverters. Moreover, we propose a distributed integral controller based on averaging algorithms which dynamically...... regulates the system frequency in the presence of a time-varying load. Remarkably, this distributed-averaging integral controller has the additional property that it maintains the power sharing properties of the primary droop controller. Finally, we present experimental results validating our controller...
Trust and controlling

OpenAIRE

Bieńkowska Agnieszka; Zabłocka-Kluczka Anna

2016-01-01

The purpose of this study is to discuss the trust within and towards an organisation in the context of implementation of controlling therein. In this context the essence of trust and its importance in organisation management was presented, as well as trust in the contemporary management methods and concepts. Controlling as a trust-building factor inside an organisation was pointed out. Especially controlling and control were described. Moreover management by considering deviations in controll...
Control rod drives

International Nuclear Information System (INIS)

Hayakawa, Hiroyasu; Kawamura, Atsuo.

1979-01-01

Purpose: To reduce pellet-clad mechanical interactions, as well as improve the fuel safety. Constitution: In the rod drive of a bwr type reactor, an electric motor operated upon intermittent input such as of pulse signals is connected to a control rod. A resolver for converting the rotational angle of the motor to electric signals is connected to the rotational shaft of the motor and the phase difference between the output signal from the resolver and a reference signal is adapted to detect by a comparator. Based on the detection result, the controller is actuated to control a motor for control rod drive so that fine control for the movement of the control rod is made possible. This can reduce the moving distance of the control rod, decrease the thermal stress applied to the control rod and decrease the pellet clad mechanical interaction failures due to thermal expansion between the cladding tube and the pellets caused by abrupt changes in the generated power. (Furukawa, Y.)
Process control device

International Nuclear Information System (INIS)

Hayashi, Toshifumi; Kobayashi, Hiroshi.

1994-01-01

A process control device comprises a memory device for memorizing a plant operation target, a plant state or a state of equipments related with each other as control data, a read-only memory device for storing programs, a plant instrumentation control device or other process control devices, an input/output device for performing input/output with an operator, and a processing device which conducts processing in accordance with the program and sends a control demand or a display demand to the input/output device. The program reads out control data relative to a predetermined operation target, compares and verify them with actual values to read out control data to be a practice premise condition which is further to be a practice premise condition if necessary, thereby automatically controlling the plant or requiring or displaying input. Practice presuming conditions for the operation target can be examined succesively in accordance with the program without constituting complicated logical figures and AND/OR graphs. (N.H.)
Failure in activation of the canonical NF-κB pathway by human T-cell leukemia virus type 1 Tax in non-hematopoietic cell lines

Energy Technology Data Exchange (ETDEWEB)

Mizukoshi, Terumi; Komori, Hideyuki; Mizuguchi, Mariko [Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 (Japan); Abdelaziz, Hussein [Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 (Japan); Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura (Egypt); Hara, Toshifumi [Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 (Japan); Higuchi, Masaya [Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata (Japan); Tanaka, Yuetsu [Department of Immunology, Graduate School and Faculty of Medicine, Ryukyu University, Okinawa (Japan); Ohara, Yoshiro [Department of Microbiology, Kanazawa Medical University, Ishikawa (Japan); Funato, Noriko [Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 (Japan); Fujii, Masahiro [Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata (Japan); Nakamura, Masataka, E-mail: naka.gene@tmd.ac.jp [Human Gene Sciences Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 (Japan)

2013-09-01

Human T-cell leukemia virus type 1 (HTLV-1) Tax (Tax1) plays crucial roles in leukemogenesis in part through activation of NF-κB. In this study, we demonstrated that Tax1 activated an NF-κB binding (gpκB) site of the gp34/OX40 ligand gene in a cell type-dependent manner. Our examination showed that the gpκΒ site and authentic NF-κB (IgκB) site were activated by Tax1 in hematopoietic cell lines. Non-hematopoietic cell lines including hepatoma and fibroblast cell lines were not permissive to Tax1-mediated activation of the gpκB site, while the IgκB site was activated in those cells in association with binding of RelB. However RelA binding was not observed in the gpκB and IgκB sites. Our results suggest that HTLV-1 Tax1 fails to activate the canonical pathway of NF-κB in non-hematopoietic cell lines. Cell type-dependent activation of NF-κB by Tax1 could be associated with pathogenesis by HTLV-1 infection. - Highlights: • HTLV-1 Tax1 does not activate RelA of NF-κB in non-hematopoietic cell lines. • Tax1 activates the NF-κB non-canonical pathway in non-hematopoietic cell lines. • Tax1 does not induce RelA nuclear translocation in those cell lines, unlike TNFα. • The OX40L promoter κB site is activated by ectopic, but not endogenous, RelA.
Fuzzy Coordinated PI Controller: Application to the Real-Time Pressure Control Process

Directory of Open Access Journals (Sweden)

N. Kanagaraj

2008-01-01

Full Text Available This paper presents the real-time implementation of a fuzzy coordinated classical PI control scheme for controlling the pressure in a pilot pressure tank system. The fuzzy system has been designed to track the variation parameters in a feedback loop and tune the classical controller to achieve a better control action for load disturbances and set point changes. The error and process inputs are chosen as the inputs of fuzzy system to tune the conventional PI controller according to the process condition. This online conventional controller tuning technique will reduce the human involvement in controller tuning and increase the operating range of the conventional controller. The proposed control algorithm is experimentally implemented for the real-time pressure control of a pilot air tank system and validated using a high-speed 32-bit ARM7 embedded microcontroller board (ATMEL AT91M55800A. To demonstrate the performance of the fuzzy coordinated PI control scheme, results are compared with a classical PI and PI-type fuzzy control method. It is observed that the proposed controller structure is able to quickly track the parameter variation and perform better in load disturbances and also for set point changes.
Location of external state financial control in national control system of Ukraine

Directory of Open Access Journals (Sweden)

N.G. Vygovska

2016-12-01

Full Text Available The article estimates the theoretical basis of the external state financial control in Ukraine in the context of defining its place in the formation of the functional areas of internal and external controls in order to eliminate duplication of a single national control system. The authors have investigated the scientific approaches to the interpretation of the concept of «external state financial control», «internal financial control», «public audit» in order to eliminate terminological confusion. It were found the differences between the external and internal financial control on the basis of comparative characteristics of such features as the entity controlling entities, controlled objects, object methods, and direction control. The concept of internal and external controls are considered to expedient to communicate with the system in which this control is identified. «Internal» in this case is identical intra-control, that is located within the executive branch, while an external control is not included in it and is external to the executive bodies of the controlled institution, and is not related to them and, as a consequence, independent. The authors suggest to form a unified system of state financial control, a clear distinction between internal and external powers of species. The authors consider that appropriate in this context will be the adoption of a single legislative act «About State Financial Control», the proposed structure is introduced in the article. Implementation of this law will contribute to the clear division of functional areas of the state control (internal and external, the elimination of departmental conflicts, and promote the formation of a single integrated control system in Ukraine, able to counteract abuses and prevent the possible loss of budgetary funds.
Control of equipment isolation system using wavelet-based hybrid sliding mode control

Science.gov (United States)

Huang, Shieh-Kung; Loh, Chin-Hsiung

2017-04-01

Critical non-structural equipment, including life-saving equipment in hospitals, circuit breakers, computers, high technology instrumentations, etc., is vulnerable to strong earthquakes, and on top of that, the failure of the vibration-sensitive equipment will cause severe economic loss. In order to protect vibration-sensitive equipment or machinery against strong earthquakes, various innovative control algorithms are developed to compensate the internal forces that to be applied. These new or improved control strategies, such as the control algorithms based on optimal control theory and sliding mode control (SMC), are also developed for structures engineering as a key element in smart structure technology. The optimal control theory, one of the most common methodologies in feedback control, finds control forces through achieving a certain optimal criterion by minimizing a cost function. For example, the linear-quadratic regulator (LQR) was the most popular control algorithm over the past three decades, and a number of modifications have been proposed to increase the efficiency of classical LQR algorithm. However, except to the advantage of simplicity and ease of implementation, LQR are susceptible to parameter uncertainty and modeling error due to complex nature of civil structures. Different from LQR control, a robust and easy to be implemented control algorithm, SMC has also been studied. SMC is a nonlinear control methodology that forces the structural system to slide along surfaces or boundaries; hence this control algorithm is naturally robust with respect to parametric uncertainties of a structure. Early attempts at protecting vibration-sensitive equipment were based on the use of existing control algorithms as described above. However, in recent years, researchers have tried to renew the existing control algorithms or developing a new control algorithm to adapt the complex nature of civil structures which include the control of both structures and non
Controlling Separation in Turbomachines

Science.gov (United States)

Evans, Simon; Himmel, Christoph; Power, Bronwyn; Wakelam, Christian; Xu, Liping; Hynes, Tom; Hodson, Howard

2010-01-01

Four examples of flow control: 1) Passive control of LP turbine blades (Laminar separation control). 2) Aspiration of a conventional axial compressor blade (Turbulent separation control). 3) Compressor blade designed for aspiration (Turbulent separation control). 4.Control of intakes in crosswinds (Turbulent separation control).
control of a dc motor using fuzzy logic control algorithm

African Journals Online (AJOL)

user

controller in the control performance of an industrial type DC motor using MATLAB. The fuzzy logic .... controlled separately excited permanent magnet DC motor (PMDC). ... When the field current is constant, the flux induced by the field ...
Different control applications on a vehicle using fuzzy logic control

Indian Academy of Sciences (India)

Vehicle vibrations; active suspensions; fuzzy logic control; vehicle model. 1. .... The general expression of the mathematical model is shown below: .... Figure 5a presents the time history of the control force when the controller exists only under.
Performance Comparison of Controllers with Fault-Dependent Control Allocation for UAVs

DEFF Research Database (Denmark)

Nørgaard Sørensen, Mikkel Eske; Hansen, Søren; Breivik, Morten

2017-01-01

This paper combines fault-dependent control allocation with three different control schemes to obtain fault tolerance in the longitudinal control of unmanned aerial vehicles. The paper shows that fault-dependent control allocation is able to accommodate actuator faults that would otherwise be cri...
Robust Control of a Hydraulically Actuated Manipulator Using Sliding Mode Control

DEFF Research Database (Denmark)

Hansen, Michael Rygaard; Andersen, Torben Ole; Pedersen, Henrik Clemmensen

2005-01-01

This paper presents an approach to robust control called sliding mode control (SMC) applied to the a hydraulic servo system (HSS), consisting of a servo valve controlled symmetrical cylinder. The motivation for applying sliding mode control to hydraulically actuated systems is its robustness...
Discrete Control Processes, Dynamic Games and Multicriterion Control Problems

Directory of Open Access Journals (Sweden)

Dumitru Lozovanu

2002-07-01

Full Text Available The discrete control processes with state evaluation in time of dynamical system is considered. A general model of control problems with integral-time cost criterion by a trajectory is studied and a general scheme for solving such classes of problems is proposed. In addition the game-theoretical and multicriterion models for control problems are formulated and studied.
Electricity sequence control

International Nuclear Information System (INIS)

Shin, Heung Ryeol

2010-03-01

The contents of the book are introduction of control system, like classification and control signal, introduction of electricity power switch, such as push-button and detection switch sensor for induction type and capacitance type machinery for control, solenoid valve, expression of sequence and type of electricity circuit about using diagram, time chart, marking and term, logic circuit like Yes, No, and, or and equivalence logic, basic electricity circuit, electricity sequence control, added condition, special program control about choice and jump of program, motor control, extra circuit on repeat circuit, pause circuit in a conveyer, safety regulations and rule about classification of electricity disaster and protective device for insulation.
Mathematical control theory

International Nuclear Information System (INIS)

Agrachev, A.A.

2002-01-01

This volume is based on the lecture notes of the minicourses given in the frame of the school on Mathematical Control Theory held at the Abdus Salam ICTP from 3 to 28 September 2001. Mathematical Control Theory is a rapidly growing field which provides strict theoretical and computational tools for dealing with problems arising in electrical and aerospace engineering, automatics, robotics, applied chemistry, and biology etc. Control methods are also involved in questions pertaining to the development of countries in the South, such as wastewater treatment, agronomy, epidemiology, population dynamics, control of industrial and natural bio-reactors. Since most of these natural processes are highly nonlinear, the tools of nonlinear control are essential for the modelling and control of such processes. At present regular courses in Mathematical Control Theory are rarely included in the curricula of universities, and very few researchers receive enough background in the field. Therefore it is important to organize specific activities in the form of schools to provide the necessary background for those embarking on research in this field. The school at the Abdus Salam ICTP consisted of several minicourses intended to provide an introduction to various topics of Mathematical Control Theory, including Linear Control Theory (finite and infinite-dimensional), Nonlinear Control, and Optimal Control. The last week of the school was concentrated on applications of Mathematical Control Theory, in particular, those which are important for the development of non-industrialized countries. The school was intended primarily for mathematicians and mathematically oriented engineers at the beginning of their career. The typical participant was expected to be a graduate student or young post-doctoral researcher interested in Mathematical Control Theory. It was assumed that participants have sufficient background in Ordinary Differential Equations and Advanced Calculus. The volume
Mathematical control theory

Energy Technology Data Exchange (ETDEWEB)

Agrachev, A A [Steklov Mathematical Institute, Moscow (Russian Federation); SISSA, Trieste [Italy; ed.

2002-07-15

This volume is based on the lecture notes of the minicourses given in the frame of the school on Mathematical Control Theory held at the Abdus Salam ICTP from 3 to 28 September 2001. Mathematical Control Theory is a rapidly growing field which provides strict theoretical and computational tools for dealing with problems arising in electrical and aerospace engineering, automatics, tics, applied chemistry, and biology etc. Control methods are also involved in questions pertaining to the development of countries in the South, such as wastewater treatment, agronomy, epidemiology, population dynamics, control of industrial and natural bio-reactors. Since most of these natural processes are highly nonlinear, the tools of nonlinear control are essential for the modelling and control of such processes. At present regular courses in Mathematical Control Theory are rarely included in the curricula of universities, and very few researchers receive enough background in the field. Therefore it is important to organize specific activities in the form of schools to provide the necessary background for those embarking on research in this field. The school at the Abdus Salam ICTP consisted of several minicourses intended to provide an introduction to various topics of Mathematical Control Theory, including Linear Control Theory (finite and infinite-dimensional), Nonlinear Control, and Optimal Control. The last week of the school was concentrated on applications of Mathematical Control Theory, in particular, those which are important for the development of non-industrialized countries. The school was intended primarily for mathematicians and mathematically oriented engineers at the beginning of their career. The typical participant was expected to be a graduate student or young post-doctoral researcher interested in Mathematical Control Theory. It was assumed that participants have sufficient background in Ordinary Differential Equations and Advanced Calculus. The volume contains
A Robust H ∞ Controller for an UAV Flight Control System.

Science.gov (United States)

López, J; Dormido, R; Dormido, S; Gómez, J P

2015-01-01

The objective of this paper is the implementation and validation of a robust H ∞ controller for an UAV to track all types of manoeuvres in the presence of noisy environment. A robust inner-outer loop strategy is implemented. To design the H ∞ robust controller in the inner loop, H ∞ control methodology is used. The two controllers that conform the outer loop are designed using the H ∞ Loop Shaping technique. The reference vector used in the control architecture formed by vertical velocity, true airspeed, and heading angle, suggests a nontraditional way to pilot the aircraft. The simulation results show that the proposed control scheme works well despite the presence of noise and uncertainties, so the control system satisfies the requirements.
Description of a research reactor control system using a programmable controller

International Nuclear Information System (INIS)

Battle, R.E.

1986-01-01

This paper describes the design features, testing methods, and operational experience of a programmable controller (PC) installed as a neutron flux controller in the Oak Ridge Research Reactor (ORR) at Oak Ridge National Laboratory (ORNL). The PC was designed to control neutron flux from 1 to 105% for three selectable ranges. The PC generates a flux setpoint under operator control, calculates the reactor heat power from flow and temperature signals, calculates a neutron flux calibration factor based on the heat power, and positions a control rod based on the flux-setpoint difference. The programmable controller was tested by controlling an analog computer model of the ORR. The equipment was installed in August 1985, and except for some startup problems, the system has performed well

Remote controlled gate controller using a GSM network and Arduino platform

Directory of Open Access Journals (Sweden)

Pospisilik Martin

2016-01-01

Full Text Available Most remote controllers for entrance gates operate on free frequencies 433 or 868 MHz. However, this technology limits the user comfort, as it is usually not common that bi-directional communication is established. A higher comfort of controlling the entrance gates can be achieved by employing the GSM network for transmission of commands and messages between the gate controller and the user. In this case, only a conventional GSM cellular phone is needed to control the gate. A description of such a controller based on the GSM module and Arduino controller is provided in this paper.
Slug control system; Sistema de controle de golfadas

Energy Technology Data Exchange (ETDEWEB)

Borges Filho, Alvaro de Miranda; Meira, Marco Antonio Alves de; Vaz, Celio Eduardo Martins [PETROBRAS, Macae, RJ (Brazil). Unidade de Negocios da Bacia de Campos

2004-07-01

Due to the characteristics of flow, gas can separate from oil in the pipelines and risers that link subsea manifolds to production offshore platforms, forming liquid and gas slugs in the production separator. Liquid slugs can cause overflow in the separators. Gas slugs can cause burning in the flare due to the limitation in the turbo-compressors acceleration. In both cases the consequences are loss of production or shut-downs. This paper presents a Slug Control System designed to attenuate severe gas and liquid flow variations. The system consist of a control valve installed in the separator inlet, transmitters, a controller, control algorithm and a monitoring station. This system is operating since October 2003 in a production offshore platform, in Campus Basin, Brazil, with excellent results, reducing the gas burning in 45% without oil production loss. (author)
PLMPC - supervisor predictive control; PLMPC - controle supervisorio preditivo

Energy Technology Data Exchange (ETDEWEB)

Ferreira, Amalia Burger Santa Brigida; Matuck, Fuad Jorge [White Martins S.A., Rio de Janeiro, RJ (Brazil)

2010-07-01

MPC is the latest and most sophisticated technology for controlling chemical plants with several interactive variables. Since 1984, over 2000 MPC systems have been installed worldwide, mostly at oil refineries and large petrochemical facilities. Praxair was the first company to apply MPC technology to the air separation industry. MPC technology is now Praxair's standard platform for supervisory control of cryogenic air separation plants. Most new Praxair plants are controlled by MPC systems. The Pipeline MPC (PLMPC) drives at least 2 plants, A and B, GO2 production towards optimum targets during the pipeline variations. The purpose of the PLMPC is to optimize gas oxygen (GO2) production according to demand, while ensuring a quickly pipeline response. It is implemented using AspenTech DMCPlus software, which is configured with a model file and a controller configuration file, that executes periodically. (author)
Birth control, population control, and family planning: an overview.

Science.gov (United States)

Critchlow, D T

1995-01-01

This overview of the US birth control movement reflects on the emergence of family planning policy due to the efforts of Margaret Sanger, feminists, and the civil rights movement, the eugenics motive to limit "deviant" populations, and the population control movement, which aims to solve social and economic problems through fertility control. Population control moved through three stages: from the cause of "voluntary motherhood" to advance suffrage and women's political and social status, to the concept of "birth control" promoted by socialist feminists to help empower women and the working class, to, from 1920 on, a liberal movement for civil rights and population control. Physicians such as Dr. Robert Latou Dickinson legitimized the movement in the formation of the Committee on Maternal Health in 1925, but the movement remained divided until 1939, when Sanger's group merged with the American Birth Control League, the predecessor of the present Planned Parenthood Federation of America. A key legal decision in 1939 in the United States v. One Package amended the Comstock Act and allowed for the distribution of birth control devices by mail to physicians. Sanger, after a brief retirement, formed the International Planned Parenthood Federation and supported research into the pill. Eugenicists through the Committee on Maternal Health supported Christopher Tietze and others developing the pill. Final constitutional access to contraception based on the right to privacy was granted in Griswold v. Connecticut. The ruling in Eisenstadt v. Baird in 1972 extended this right to unmarried persons. The right to privacy was further extended in the Roe v. Wade decision in 1973 on legal abortion. The argument for improving the quality of the population remained from the formation of the Population Reference Bureau in 1929 through the 1960s. Under the leadership of Rockefeller, population control was defined as justified on a scientific and humanitarian basis. US government support
The Design of Optimal PID Control Method for Quadcopter Movement Control

Directory of Open Access Journals (Sweden)

Hanum Arrosida

2018-02-01

Full Text Available Nowadays, quadcopter motion control has become a popular research topic because of its versatile ability as an unmanned aircraft can be used to alleviate human labor and also be able to reach dangerous areas or areas which is unreachable to humans. On the other hand, the Optimal PID control method, which incorporates PID and Linear Quadratic Regulator (LQR control methods, has also been widely used in industry and research field because it has advantages that are easy to operate, easy design, and a good level of precision. In the PID control method, the main problem to be solved is the accuracy of the gain value Kp, Ki, and Kd because the inappropriateness of those value will result in an imprecise control action. Based on these problems and referring to the previous study, the optimal PID control method was developed by using PID controller structure with tuning gain parameter of PID through Linear Quadratic Regulator (LQR method. Through the integration of these two control methods, the optimum solutions can be obtained: easier controller design process for quadcopter control when crossing the determined trajectories, steady state error values less than 5% and a stable quadcopter movement with roll and pitch angle stabilization at position 0 radians with minimum energy function.
Current control of PMSM based on maximum torque control reference frame

Science.gov (United States)

Ohnuma, Takumi

2017-07-01

This study presents a new method of current controls of PMSMs (Permanent Magnet Synchronous Motors) based on a maximum torque control reference frame, which is suitable for high-performance controls of the PMSMs. As the issues of environment and energy increase seriously, PMSMs, one of the AC motors, are becoming popular because of their high-efficiency and high-torque density in various applications, such as electric vehicles, trains, industrial machines, and home appliances. To use the PMSMs efficiently, a proper current control of the PMSMs is necessary. In general, a rotational coordinate system synchronizing with the rotor is used for the current control of PMSMs. In the rotating reference frame, the current control is easier because the currents on the rotating reference frame can be expressed as a direct current in the controller. On the other hand, the torque characteristics of PMSMs are non-linear and complex; the PMSMs are efficient and high-density though. Therefore, a complicated control system is required to involve the relation between the torque and the current, even though the rotating reference frame is adopted. The maximum torque control reference frame provides a simpler way to control efficiently the currents taking the torque characteristics of the PMSMs into consideration.
Real-time measurement and control at Jet. Experiment Control

International Nuclear Information System (INIS)

Felton, R.; Zabeo, L.; Sartori, F.; Piccolo, F.; Farthing, J.; Budd, T.; Dorling, S.; McCullen, P.; Harling, J.; Dalley, S.; Goodyear, A.; Stephen, A.; Card, P.; Bright, M.; Lucock, R.; Jones, E.; Griph, S.; Hogben, C.; Beldishevski, M.; Buckley, M.; Davis, J.; Young, I.; Hemming, O.; Wheatley, M.; Heesterman, P.; Lloyd, G.; Walters, M.; Bridge, R.; Leggate, H.; Howell, D.; Zastrow, K.D.; Giroud, C.; Coffey, I.; Hawkes, N.; Stamp, M.; Barnsley, R.; Edlington, T.; Guenther, K.; Gowers, C.; Popovichef, S.; Huber, A.; Ingesson, C.; Joffrin, E.; Mazon, D.; Moreau, D.; Murari, A.; Riva, M.; Barana, O.; Bolzonella, T.; Valisa, M.; Innocente, P.; Zerbini, M.; Bosak, K.; Blum, J.; Vitale, E.; Crisanti, F.; La Luna, E. de; Sanchez, J.

2004-01-01

Over the past few ears, the preparation of ITER-relevant plasma scenarios has been the main focus experimental activity on tokamaks. The development of integrated, simultaneous, real-time controls of plasma shape, current, pressure, temperature, radiation, neutron profiles, and also impurities, ELMs (edge localized modes) and MHD are now seen to be essential for further development of quasi-steady state conditions with feedback, or the stabilisation of transient phenomena with event-driven actions. For this thrust, the EFDA JET Real Time Project has developed a set of real-time plasma measurements, experiment control, and communication facilities. The Plasma Diagnostics used for real-time experiments are Far Infra Red interferometry, polarimetry, visible, UV and X-ray spectroscopy, LIDAR, bolometry, neutron and magnetics. Further analysis systems produce integrated results such as temperature profiles on geometry derived from MHD equilibrium solutions. The Actuators include toroidal, poloidal and divertor coils, gas and pellet fuelling, neutral beam injection, radiofrequency (ICRH) waves and microwaves (LH). The Heating/Fuelling Operators can either define a power or gas request waveform or select the real-time instantaneous power/gas request from the Real Time Experiment Central Control (RTCC) system. The Real Time Experiment Control system provides both a high-level, control-programming environment and interlocks with the actuators. A MATLAB facility is being developed for the development of more complex controllers. The plasma measurement, controller and plant control systems communicate in ATM network. The EFDA Real Time project is essential groundwork for future reactors such as ITER. It involves many staff from several institutions. The facility is now frequently used in experiments. (authors)
Digital control for turbogas units; Control digital para unidades turbogas

Energy Technology Data Exchange (ETDEWEB)

Garcia Beltran, Carlos Daniel

1997-02-01

The present thesis deals with the rehabilitation of the control system for the gas turbines W501 of the Gomez Palacio Combined Cycle Power Station in the state of Durango, Mexico. The first part of the development deals with a re-engineering process of software applied to the digital control system of the gas turbines of the Gomez Palacio Combined Cycle Power Station. This process was developed using concepts of several branches of engineering: a) involved the knowledge of the software engineering, using formal methods for the analysis of the original system and the redesign of the new system; b) The control engineering was used in the analysis of diverse control and automation strategies employed for gas turbines control, with the objective of verifying the type of instructions and existing routines within the software. The final product of this stage is a modulated programmatic system, based on structured design that is functionally a mirror image of the original system. The system obtained conformed by five main modules which are based on a model proposed originally for control by batch: i) Man Machine Interface, ii) Regulatory Control, iii) Protections, iv) Logic sequences and v) Supervision. The second stage of development was the improvement of the speed control of the turbine. When a turbogas unit is controlled, it must be taken into account several operation stages such as the starting, the control in stable state and the shut down. The real behavior of the turbine during the starting, and mainly the great number of backward movements produced, proposed by itself the search of a new controller who more closely maintained the acceleration specifications whereupon the turbine was designed. The development of a new control algorithm began with the analysis of the process, trying to identify which are the critical stages of this one and be able to evaluate in an objective form the advantages of an algorithm upon the other. It was continued with the
Real-time tracking control of electro-hydraulic force servo systems using offline feedback control and adaptive control.

Science.gov (United States)

Shen, Gang; Zhu, Zhencai; Zhao, Jinsong; Zhu, Weidong; Tang, Yu; Li, Xiang

2017-03-01

This paper focuses on an application of an electro-hydraulic force tracking controller combined with an offline designed feedback controller (ODFC) and an online adaptive compensator in order to improve force tracking performance of an electro-hydraulic force servo system (EHFS). A proportional-integral controller has been employed and a parameter-based force closed-loop transfer function of the EHFS is identified by a continuous system identification algorithm. By taking the identified system model as a nominal plant model, an H ∞ offline design method is employed to establish an optimized feedback controller with consideration of the performance, control efforts, and robustness of the EHFS. In order to overcome the disadvantage of the offline designed controller and cope with the varying dynamics of the EHFS, an online adaptive compensator with a normalized least-mean-square algorithm is cascaded to the force closed-loop system of the EHFS compensated by the ODFC. Some comparative experiments are carried out on a real-time EHFS using an xPC rapid prototype technology, and the proposed controller yields a better force tracking performance improvement. Copyright © 2016. Published by Elsevier Ltd.
Controller for control of pulsed electron linear accelerator

International Nuclear Information System (INIS)

Bryazgin, A.A.; Faktorovich, B.L.

1995-01-01

The controller is based on the K1816VE31 microprocessor and contains 22-channel integrating 10-digital two-wire analog-to-digital converter, 8-channel 12-digit digital-to-analog converter, 24-digit output register, 16-digit input register pulse generator in the range of 0.5 - 50 Hz with the regulation step of 0.05 Hz and delayed pulse generator. The controller is used for pulsed electron linear accelerator control and is reduced to regulation of the electron beam pulse repetition rate and beam energy. 1 ref., 1 fig
Adaptive Dynamic Surface Control for Generator Excitation Control System

Directory of Open Access Journals (Sweden)

Zhang Xiu-yu

2014-01-01

Full Text Available For the generator excitation control system which is equipped with static var compensator (SVC and unknown parameters, a novel adaptive dynamic surface control scheme is proposed based on neural network and tracking error transformed function with the following features: (1 the transformation of the excitation generator model to the linear systems is omitted; (2 the prespecified performance of the tracking error can be guaranteed by combining with the tracking error transformed function; (3 the computational burden is greatly reduced by estimating the norm of the weighted vector of neural network instead of the weighted vector itself; therefore, it is more suitable for the real time control; and (4 the explosion of complicity problem inherent in the backstepping control can be eliminated. It is proved that the new scheme can make the system semiglobally uniformly ultimately bounded. Simulation results show the effectiveness of this control scheme.
Cybernetical Physics From Control of Chaos to Quantum Control

CERN Document Server

Fradkov, Alexander L

2007-01-01

The control of complex systems is one of the most important aspects in dealing with systems exhibiting nonlinear behaviour or similar features that defy traditional control techniques. This specific subject is gradually becoming known as cybernetical physics, borrowing methods from both theoretical physics and control engineering. This book is, perhaps, the first attempt to present a unified exposition of the subject and methodology of cybernetical physics as well as solutions to some of its problems. Emphasis of the book is on the examination of fundamental limits on energy transformation by means of control procedures in both conservative and dissipative systems. A survey of application in physics includes the control of chaos, synchronisation of coupled oscillators, pendulum chains, reactions in physical chemistry and of quantum systems such as the dissociation of diatomic molecules. This book has been written having researchers from various backgrounds in physics, mathematics and engineering in mind and i...
Dynamics and control of quadcopter using linear model predictive control approach

Science.gov (United States)

Islam, M.; Okasha, M.; Idres, M. M.

2017-12-01

This paper investigates the dynamics and control of a quadcopter using the Model Predictive Control (MPC) approach. The dynamic model is of high fidelity and nonlinear, with six degrees of freedom that include disturbances and model uncertainties. The control approach is developed based on MPC to track different reference trajectories ranging from simple ones such as circular to complex helical trajectories. In this control technique, a linearized model is derived and the receding horizon method is applied to generate the optimal control sequence. Although MPC is computer expensive, it is highly effective to deal with the different types of nonlinearities and constraints such as actuators’ saturation and model uncertainties. The MPC parameters (control and prediction horizons) are selected by trial-and-error approach. Several simulation scenarios are performed to examine and evaluate the performance of the proposed control approach using MATLAB and Simulink environment. Simulation results show that this control approach is highly effective to track a given reference trajectory.
Force Control for a Pneumatic Cylinder Using Generalized Predictive Controller Approach

Directory of Open Access Journals (Sweden)

Ahmad ’Athif Mohd Faudzi

2014-01-01

Full Text Available Pneumatic cylinder is a well-known device because of its high power to weight ratio, easy use, and environmental safety. Pneumatic cylinder uses air as its power source and converts it to a possible movement such as linear and rotary movement. In order to control the pneumatic cylinder, controller algorithm is needed to control the on-off solenoid valve with encoder and pressure sensor as the feedback inputs. In this paper, generalized predictive controller (GPC is proposed as the control strategy for the pneumatic cylinder force control. To validate and compare the performance, proportional-integral (PI controller is also presented. Both controllers algorithms GPC and PI are developed using existing linear model of the cylinder from previous research. Results are presented in simulation and experimental approach using MATLAB-Simulink as the platform. The results show that the GPC is capable of fast response with low steady state error and percentage overshoot compared to PI.
Association between product quality control and process quality control of bulk milk

NARCIS (Netherlands)

Velthuis, A.; Asseldonk, van M.A.P.M.

2010-01-01

Assessment of dairy-milk quality is based on product quality control (testing bulk-milk samples) and process quality control (auditing dairy farms). It is unknown whether process control improves product quality. To quantify possible association between product control and process control a
A Compatible Control Algorithm for Greenhouse Environment Control Based on MOCC Strategy

Directory of Open Access Journals (Sweden)

Bingkun Zhu

2011-03-01

Full Text Available Conventional methods used for solving greenhouse environment multi-objective conflict control problems lay excessive emphasis on control performance and have inadequate consideration for both energy consumption and special requirements for plant growth. The resulting solution will cause higher energy cost. However, during the long period of work and practice, we find that it may be more reasonable to adopt interval or region control objectives instead of point control objectives. In this paper, we propose a modified compatible control algorithm, and employ Multi-Objective Compatible Control (MOCC strategy and an extant greenhouse model to achieve greenhouse climate control based on feedback control architecture. A series of simulation experiments through various comparative studies are presented to validate the feasibility of the proposed algorithm. The results are encouraging and suggest the energy-saving application to real-world engineering problems in greenhouse production. It may be valuable and helpful to formulate environmental control strategies, and to achieve high control precision and low energy cost for real-world engineering application in greenhouse production. Moreover, the proposed approach has also potential to be useful for other practical control optimization problems with the features like the greenhouse environment control system.
A compatible control algorithm for greenhouse environment control based on MOCC strategy.

Science.gov (United States)

Hu, Haigen; Xu, Lihong; Zhu, Bingkun; Wei, Ruihua

2011-01-01

Conventional methods used for solving greenhouse environment multi-objective conflict control problems lay excessive emphasis on control performance and have inadequate consideration for both energy consumption and special requirements for plant growth. The resulting solution will cause higher energy cost. However, during the long period of work and practice, we find that it may be more reasonable to adopt interval or region control objectives instead of point control objectives. In this paper, we propose a modified compatible control algorithm, and employ Multi-Objective Compatible Control (MOCC) strategy and an extant greenhouse model to achieve greenhouse climate control based on feedback control architecture. A series of simulation experiments through various comparative studies are presented to validate the feasibility of the proposed algorithm. The results are encouraging and suggest the energy-saving application to real-world engineering problems in greenhouse production. It may be valuable and helpful to formulate environmental control strategies, and to achieve high control precision and low energy cost for real-world engineering application in greenhouse production. Moreover, the proposed approach has also potential to be useful for other practical control optimization problems with the features like the greenhouse environment control system.
Transformaciones del Estado y las nuevas exigencias del control de la corrupción: transparencia fiscal, control administrativo y control social

OpenAIRE

Mileski, Helio Saul

2011-01-01

[ES] Tesis doctoral sobre las transformaciones del Estado y las nuevas exigencias del control de la corrupción: transparencia fiscal, control administrativo y control social. [EN] Dissertation on the transformations of the state and the new demands of control of corruption: fiscal transparency, administrative control and social control.
Pharmacologic Rhythm Control versus Rate Control in Heart Failure and Atrial Fibrillation

Directory of Open Access Journals (Sweden)

Gladys Gladys

2017-01-01

Full Text Available Heart failure (HF with atrial fibrillation (AF is correlated with worse prognosis requiring special approach.Rate control has been the first line of treatment in cases of HF and HF. On the other hand, rhythm controlhas been proven to be effective in returning sinus rhythm resulting in better prognosis for patients with HFbut not HF. Its role in cocurring cases of HF and AF is not fully understood. Thus, this study aims to analysewhether pharmacologic rhythm control can be applied to cases of HF and AF to reduce mortality. A searchwas conducted via PubMed, Medline, ProQuest, and Cochrane Database on January 2016. One study wasselected after filtering process by inclusion and exclusion criteria and critical appraisal was performed. It wasfound that there was rhythm control and rate control do no have favouring effect towards mortality shown byRR 1.03 (95% CI 0.90-1.17, p=0.69. Rate control has protective effect towards hospitalizations by RR of 0.92(95% CI 0.86 – 0.98, p=0.008, NNT=19. To conclude, rhythm control is not superior to rate control in reducingmortality and rate control should be still be considered as first line treatment of HF and AF. Keywords: heart failure, pharmacologic rhythm control, rate control, atrial fibrillation Farmakologis Rhythm Control Dibandingkan dengan Rate Control padaKasus Gagal Jantung dan Atrial Fibrilasi Abstrak Gagal jantung dengan atrial fibrilasi berhubungan dengan prognosis yang lebih buruk dan membutuhkanpenanganan khusus. Saat ini strategi rate control merupakan terapi lini pertama pada kasus gagal jantungdan atrial fibrilasi. Rhythm control memberikan prognosis yang lebih baik pada pasien gagal jantung denganmengembalikan sinus ritme. Kegunaan rhythm control pada kasus gagal jantung dan atrial fibrilasi sampaisaat ini belum sepenuhnya dimengerti. Tujuan studi ini adalah menelaah apakah terapi farmakologis rhythmcontrol dapat menurunkan mortalitas gagal jantung dan atrial fibrilasi. Pencarian data
A controllability approach to the control of a class of chaotic systems

International Nuclear Information System (INIS)

Bowong, Samuel; Moukam Kakmeni, F.M.; Tchawoua, Clement; Abdus Salam International Centre for Theoretical Physics, Trieste

2003-10-01

In this paper the exponential control problem for a class of chaotic systems with affine dependence on the control is addressed and solved by the controllability approach. It is shown that the controllability approach in conjunction with Lyapunov Direct Method yields a promising way of controlling chaotic dynamics. The proposed strategy is an input-output control scheme which comprises a state estimator and an exponential linearizing feedback. The proposed output feedback controller allows chaos suppression and can be applied to a large class of chaotic systems. Explicit expression of the control time is given. Computer simulations confirm the feasibility of the proposed approach. (author)

Wide-range nuclear reactor temperature control using automatically tuned fuzzy logic controller

International Nuclear Information System (INIS)

Ramaswamy, P.; Edwards, R.M.; Lee, K.Y.

1992-01-01

In this paper, a fuzzy logic controller design for optimal reactor temperature control is presented. Since fuzzy logic controllers rely on an expert's knowledge of the process, they are hard to optimize. An optimal controller is used in this paper as a reference model, and a Kalman filter is used to automatically determine the rules for the fuzzy logic controller. To demonstrate the robustness of this design, a nonlinear six-delayed-neutron-group plant is controlled using a fuzzy logic controller that utilizes estimated reactor temperatures from a one-delayed-neutron-group observer. The fuzzy logic controller displayed good stability and performance robustness characteristics for a wide range of operation
Proxemic-aware controls

DEFF Research Database (Denmark)

Ledo, David; Greenberg, Saul; Marquardt, Nicolai

2015-01-01

Remote controls facilitate interactions at-a-distance with appliances. However, the complexity, diversity, and in-creasing number of digital appliances in ubiquitous com-puting ecologies make it increasingly difficult to: (1) dis-cover which appliances are controllable; (2) select a par-ticular a......Remote controls facilitate interactions at-a-distance with appliances. However, the complexity, diversity, and in-creasing number of digital appliances in ubiquitous com-puting ecologies make it increasingly difficult to: (1) dis-cover which appliances are controllable; (2) select a par......-ticular appliance from the large number available; (3) view information about its status; and (4) control the ap-pliance in a pertinent manner. To mitigate these problems we contribute proxemic-aware controls, which exploit the spatial relationships between a person's handheld de-vice and all surrounding appliances...... to create a dynamic appliance control interface. Specifically, a person can discover and select an appliance by the way one orients a mobile device around the room, and then progressively view the appliance's status and control its features in in-creasing detail by simply moving towards it. We illus...
Control rod drives

International Nuclear Information System (INIS)

Oonuki, Koji.

1981-01-01

Purpose: To increase the driving speed of control rods at rapid insertion with an elongate control rod and an extension pipe while ensuring sufficient buffering performance in a short buffering distance, by providing a plurality of buffers to an extension pipe between a control rod drive source and a control rod in LMFBR type reactor. Constitution: First, second and third buffers are respectively provided to an acceleration piston, an extension pipe and a control rod respectively and the insertion positions for each of the buffers are displaced orderly from above to below. Upon disconnection of energizing current for an electromagnet, the acceleration piston, the extension pipe and the control rod are rapidly inserted in one body. The first, second and third buffers are respectively actuated at each of their falling strokes upon rapid insertion respectively, and the acceleration piston, the extension pipe and the control rod receive the deceleration effect in the order correspondingly. Although the compression force is applied to the control rod only near the stroke end, it does not cause deformation. (Kawakami, Y.)
Plasma position control device

International Nuclear Information System (INIS)

Takase, Haruhiko.

1987-01-01

Purpose: To conduct position control stably to various plasmas and reduce the burden on the control coil power source. Constitution: Among the proportional, integration and differentiation controls, a proportional-differentiation control section and an integration control section are connected in parallel. Then, a signal switching circuit is disposed to the control signal input section for the proportional-differentiation control section such that either a present position of plasmas or deviation between the present plasma position and an aimed value can be selected as a control signal depending on the control procedures or the state of the plasmas. For instance, if a rapid response is required for the control, the deviation between the present plasma position and the aimed value is selected as the input signal to conduct proportional, integration and differentiation controls. While on the other hand, if it is intended to reduce the burden on the control coil power source, it is adapted such that the control signal inputted to the proportional-differentiation control section itself can select the present plasma position. (Yoshihara, H.)
Controllable dose; Dosis controlable

Energy Technology Data Exchange (ETDEWEB)

Alvarez R, J T; Anaya M, R A [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

2004-07-01

With the purpose of eliminating the controversy about the lineal hypothesis without threshold which found the systems of dose limitation of the recommendations of ICRP 26 and 60, at the end of last decade R. Clarke president of the ICRP proposed the concept of Controllable Dose: as the dose or dose sum that an individual receives from a particular source which can be reasonably controllable by means of any means; said concept proposes a change in the philosophy of the radiological protection of its concern by social approaches to an individual focus. In this work a panorama of the foundations is presented, convenient and inconveniences that this proposal has loosened in the international community of the radiological protection, with the purpose of to familiarize to our Mexican community in radiological protection with these new concepts. (Author)
Pressure control of a pneumatic control system with a long transmission line

International Nuclear Information System (INIS)

Jang, Ji Seong; Lee, Kwang Kuk; Choi, Myung Soo

2003-01-01

In this study, a robust controller to control pressure in a pneumatic pressure vessel with a long transmission line is proposed. Frequency response of transmission line using compressible fluid is changed by the flowing state of the fluid. So, if a fixed gain controller designed based on a model supposed the flowing state to a specific state, the performance of the control system could be degraded because of the modelling error. The controller designed in this study is composed of two parts. One is a feedback controller to improve a feedback characteristics and to compensate the influence of the variation of transfer characteristics of a transmission line owing to the change of flowing state and the other is a feed forward controller to regulate command following performance. The experimental results with the designed controller show that the robustness of the control system is achieved regardless of the change of the model of the transmission line. Therefore, the designed controller can be utilized for the performance improvement of a pressure control system with a long transmission line using compressible fluid
Feedback control of acoustic musical instruments: collocated control using physical analogs.

Science.gov (United States)

Berdahl, Edgar; Smith, Julius O; Niemeyer, Günter

2012-01-01

Traditionally, the average professional musician has owned numerous acoustic musical instruments, many of them having distinctive acoustic qualities. However, a modern musician could prefer to have a single musical instrument whose acoustics are programmable by feedback control, where acoustic variables are estimated from sensor measurements in real time and then fed back in order to influence the controlled variables. In this paper, theory is presented that describes stable feedback control of an acoustic musical instrument. The presentation should be accessible to members of the musical acoustics community who may have limited or no experience with feedback control. First, the only control strategy guaranteed to be stable subject to any musical instrument mobility is described: the sensors and actuators must be collocated, and the controller must emulate a physical analog system. Next, the most fundamental feedback controllers and the corresponding physical analog systems are presented. The effects that these controllers have on acoustic musical instruments are described. Finally, practical design challenges are discussed. A proof explains why changing the resonance frequency of a musical resonance requires much more control power than changing the decay time of the resonance. © 2012 Acoustical Society of America.
Phase and gain control policies for robust active vibration control of flexible structures

International Nuclear Information System (INIS)

Zhang, K; Ichchou, M N; Scorletti, G; Mieyeville, F

2013-01-01

The interest of this paper is to develop a general and systematic robust control methodology for active vibration control of flexible structures. For this purpose, first phase and gain control policies are proposed to impose qualitative frequency-dependent requirements on the controller to consider a complete set of control objectives. Then the proposed control methodology is developed by employing phase and gain control policies in the dynamic output feedback H ∞ control: according to the set of control objectives, phase and gain control policies incorporate necessary weighting functions and determine them in a rational and systematic way; on the other hand, with the appropriate weighting functions efficient H ∞ control algorithms can automatically realize phase and gain control policies and generate a satisfactory H ∞ controller. The proposed control methodology can be used for both SISO and MIMO systems with collocated or non-collocated sensors and actuators. In this paper, it is validated on a non-collocated piezoelectric cantilever beam. Both numerical simulations and experimental results demonstrate the effectiveness of the proposed control methodology. (paper)
Catastrophes control problem

International Nuclear Information System (INIS)

Velichenko, V.V.

1994-01-01

The problem of catastrophe control is discussed. Catastrophe control aims to withdraw responsible engineering constructions out of the catastrophe. The mathematical framework of catastrophes control systems is constructed. It determines the principles of systems filling by the concrete physical contents and, simultaneously, permits to employ modern control methods for the synthesis of optimal withdrawal strategy for protected objects
An approach of partial control design for system control and synchronization

International Nuclear Information System (INIS)

Hu Wuhua; Wang Jiang; Li Xiumin

2009-01-01

In this paper, a general approach of partial control design for system control and synchronization is proposed. It turns control problems into simpler ones by reducing their control variables. This is realized by utilizing the dynamical relations between variables, which are described by the dynamical relation matrix and the dependence-influence matrix. By adopting partial control theory, the presented approach provides a simple and general way to stabilize systems to their partial or whole equilibriums, or to synchronize systems with their partial or whole states. Further, based on this approach, the controllers can be simplified. Two examples of synchronizing chaotic systems are given to illustrate its effectiveness.
Controlling chaos faster

International Nuclear Information System (INIS)

Bick, Christian; Kolodziejski, Christoph; Timme, Marc

2014-01-01

Predictive feedback control is an easy-to-implement method to stabilize unknown unstable periodic orbits in chaotic dynamical systems. Predictive feedback control is severely limited because asymptotic convergence speed decreases with stronger instabilities which in turn are typical for larger target periods, rendering it harder to effectively stabilize periodic orbits of large period. Here, we study stalled chaos control, where the application of control is stalled to make use of the chaotic, uncontrolled dynamics, and introduce an adaptation paradigm to overcome this limitation and speed up convergence. This modified control scheme is not only capable of stabilizing more periodic orbits than the original predictive feedback control but also speeds up convergence for typical chaotic maps, as illustrated in both theory and application. The proposed adaptation scheme provides a way to tune parameters online, yielding a broadly applicable, fast chaos control that converges reliably, even for periodic orbits of large period
Controlling chaos faster.

Science.gov (United States)

Bick, Christian; Kolodziejski, Christoph; Timme, Marc

2014-09-01

Predictive feedback control is an easy-to-implement method to stabilize unknown unstable periodic orbits in chaotic dynamical systems. Predictive feedback control is severely limited because asymptotic convergence speed decreases with stronger instabilities which in turn are typical for larger target periods, rendering it harder to effectively stabilize periodic orbits of large period. Here, we study stalled chaos control, where the application of control is stalled to make use of the chaotic, uncontrolled dynamics, and introduce an adaptation paradigm to overcome this limitation and speed up convergence. This modified control scheme is not only capable of stabilizing more periodic orbits than the original predictive feedback control but also speeds up convergence for typical chaotic maps, as illustrated in both theory and application. The proposed adaptation scheme provides a way to tune parameters online, yielding a broadly applicable, fast chaos control that converges reliably, even for periodic orbits of large period.
Controlling chaos faster

Energy Technology Data Exchange (ETDEWEB)

Bick, Christian [Network Dynamics, Max Planck Institute for Dynamics and Self-Organization (MPIDS), 37077 Göttingen (Germany); Bernstein Center for Computational Neuroscience (BCCN), 37077 Göttingen (Germany); Institute for Mathematics, Georg–August–Universität Göttingen, 37073 Göttingen (Germany); Kolodziejski, Christoph [Network Dynamics, Max Planck Institute for Dynamics and Self-Organization (MPIDS), 37077 Göttingen (Germany); III. Physical Institute—Biophysics, Georg–August–Universität Göttingen, 37077 Göttingen (Germany); Timme, Marc [Network Dynamics, Max Planck Institute for Dynamics and Self-Organization (MPIDS), 37077 Göttingen (Germany); Institute for Nonlinear Dynamics, Georg–August–Universität Göttingen, 37077 Göttingen (Germany)

2014-09-01

Predictive feedback control is an easy-to-implement method to stabilize unknown unstable periodic orbits in chaotic dynamical systems. Predictive feedback control is severely limited because asymptotic convergence speed decreases with stronger instabilities which in turn are typical for larger target periods, rendering it harder to effectively stabilize periodic orbits of large period. Here, we study stalled chaos control, where the application of control is stalled to make use of the chaotic, uncontrolled dynamics, and introduce an adaptation paradigm to overcome this limitation and speed up convergence. This modified control scheme is not only capable of stabilizing more periodic orbits than the original predictive feedback control but also speeds up convergence for typical chaotic maps, as illustrated in both theory and application. The proposed adaptation scheme provides a way to tune parameters online, yielding a broadly applicable, fast chaos control that converges reliably, even for periodic orbits of large period.
Controlling: controllersopleiding en rol en positie van de (register) controller

NARCIS (Netherlands)

Meer-Kooistra, J. van der; Vosselman, E.G.J.

2014-01-01

Het themanummer Controlling richt zich op het overkoepelende vakgebied Controlling en meer in het bijzonder op de postinitiële Controllersopleiding oftewel Executive Master of Finance and Control, de opleiding waarin dit vakgebied centraal staat, en op de rol en positie van de afgestudeerden van
Inventory control in case of unknown demand and control parameters

NARCIS (Netherlands)

Janssen, E.

2010-01-01

This thesis deals with unknown demand and control parameters in inventory control. Inventory control involves decisions on what to order when and in what quantity. These decisions are based on information about the demand. Models are constructed using complete demand information; these models ensure
MTPA control of mechanical sensorless IPMSM based on adaptive nonlinear control.

Science.gov (United States)

Najjar-Khodabakhsh, Abbas; Soltani, Jafar

2016-03-01

In this paper, an adaptive nonlinear control scheme has been proposed for implementing maximum torque per ampere (MTPA) control strategy corresponding to interior permanent magnet synchronous motor (IPMSM) drive. This control scheme is developed in the rotor d-q axis reference frame using adaptive input-output state feedback linearization (AIOFL) method. The drive system control stability is supported by Lyapunov theory. The motor inductances are online estimated by an estimation law obtained by AIOFL. The estimation errors of these parameters are proved to be asymptotically converged to zero. Based on minimizing the motor current amplitude, the MTPA control strategy is performed by using the nonlinear optimization technique while considering the online reference torque. The motor reference torque is generated by a conventional rotor speed PI controller. By performing MTPA control strategy, the generated online motor d-q reference currents were used in AIOFL controller to obtain the SV-PWM reference voltages and the online estimation of the motor d-q inductances. In addition, the stator resistance is online estimated using a conventional PI controller. Moreover, the rotor position is detected using the online estimation of the stator flux and online estimation of the motor q-axis inductance. Simulation and experimental results obtained prove the effectiveness and the capability of the proposed control method. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.
Secondary Control Scheme for Voltage Unbalance Compensation in an Islanded Droop-Controlled Microgrid

DEFF Research Database (Denmark)

Savaghebi, Mehdi; Jalilian, Alireza; Vasquez, Juan Carlos

2012-01-01

The concept of microgrid hierarchical control is presented recently. In this paper, a hierarchical scheme is proposed which includes primary and secondary control levels. The primary level comprises distributed generators (DGs) local controllers. The local controllers mainly consist of power......, voltage and current controllers, and virtual impedance control loop. The central secondary controller is designed to manage the compensation of voltage unbalance at the point of common coupling (PCC) in an islanded microgrid. Unbalance compensation is achieved by sending proper control signals to the DGs...... local controllers. The design procedure of the control system is discussed in detail and the simulation results are presented. The results show the effectiveness of the proposed control structure in compensating the voltage unbalance....
Riot Control Agents

Science.gov (United States)

... Submit What's this? Submit Button Facts About Riot Control Agents Interim document Recommend on Facebook Tweet Share Compartir What riot control agents are Riot control agents (sometimes referred to ...
Internet congestion control

CERN Document Server

Varma, Subir

2015-01-01

Internet Congestion Control provides a description of some of the most important topics in the area of congestion control in computer networks, with special emphasis on the analytical modeling of congestion control algorithms. The field of congestion control has seen many notable advances in recent years and the purpose of this book, which is targeted towards the advanced and intermediate reader, is to inform about the most important developments in this area. The book should enable the reader to gain a good understanding of the application of congestion control theory to a number of applic
More efficient purifying scheme via controlled-controlled NOT gate

International Nuclear Information System (INIS)

Metwally, N.; Obada, A.-S.

2006-01-01

A new modified version of the Oxford purification protocol is proposed. This version is based on the controlled-controlled NOT gate instead of controlled NOT in the original one. Comparisons between the results of the new version and the original and an earlier modification are given. It is found that the new version converges faster and consumes fewer initial qubit pairs of low fidelity per final qubit pair of high fidelity

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