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Sample records for relatifs au dosage

  1. Experimental results concerning the metabolism of ingested iodine-131 in adult sheep under lactation; Resultats experimentaux relatifs au metabolisme de l'iode 131 ingere chez la brebis adulte en lactation

    Energy Technology Data Exchange (ETDEWEB)

    Daburon, F.; Capelle, A.; Tricaud, Y.; Nizza, P. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Departement de la Protection Sanitaire, Laboratoire-etable de Radiobiologie Appliquee

    1967-07-01

    The authors give the results of a series of experiments on metabolism of ingested iodine-131 in adult sheep under lactation; the measurement were carried out over a number of years from 1961 to 1966. The work was concerned initially with the fixation of iodine 131 in the thyroid gland, with the calculation of radiation doses absorbed and with ways of showing up any possible radiation damage in the gland. The modes of absorption of iodine 131 and its elimination through milk, urine and the faeces were then considered. Finally, a last chapter is devoted to changes in the radioactivity of the blood and of the milk, to variations of the PBI level of the blood serum as to different methods for measuring this level. (authors) [French] Les auteurs rapportent les resultats d'une serie d'experimentations relatives au metabolisme de l'iode 131 ingere chez la brebis adulte en lactation, et qui se sont etalees sur plusieurs annees, de 1961 a 1966. Les etudes ont porte d'abord sur les aspects de la fixation de l'iode 131 dans la thyroide, avec le calcul des doses de rayonnements absorbees et les moyens de mettre en evidence les radiolesions eventuelles de la glande. Ensuite ont ete traitees les modalites de l'absorption de l'iode 131 et de son elimination par le lait, les urines et les feces. Enfin un dernier chapitre a ete consacre a l'evolution de la radioactivite du sang et du lait, aux variations ainsi qu'aux divers moyens d'evaluation du taux de PBI du serum sanguin. (auteurs)

  2. STUDI GAYA BERAT RELATIF DI SEMARANG

    Directory of Open Access Journals (Sweden)

    - Supriyadi

    2012-01-01

    Full Text Available Gaya berat relatif adalah gaya berat yang diperoleh dari hasil pengukuran gaya berat di suatu tempat. Untuk memperoleh nilaigayaberat absolut dilakukan pengukuran gayaberat yang diikatkan dengan sistem yang sudah ada yang dikenal sebagai SistemPostdam. Sistem ini merupakan jaringan stasiun gayaberat yang dapat dimanfaatkan untuk keperluan pengkuran gayaberat relatifdi suatu tempat di permukaan bumi ini. Studi kasus pengukuran gayaberat relatif telah dilakukan di kota Semarang khususnya kotabawah dengan menggunakan alat gravimeter. Sebagai titik ikat atau titik referensi digunakan titik Kop. A. Yani 15 yang terletakTaman Diponegoro depan rumah sakit Elizabeth. Besar gayaberat di titik referensi ini adalah 978099,311 mGal. Gayaberat relatifdihitung dari selisih antara gayaberat absolut dengan gayaberat hasil pengukuran yang sudah dikoreksi. Hasil penelitianmenunjukkan bahwa gayaberat di bagian utara kota Semarang lebih besar dibandingkan dengan bagian selatan. Hal ini sesuaidengan topografi kota Semarang, dimana bagian utara lebih rendah dibandingkan dengan bagian selatan. A relative gravity obtained through a measurement activity of gravity in a certain place. The absolute value of gravity could be drawnby conducting a measurement based on called the existing Postdam system. This system consists of gravity's station network thatcan be used to calculate a relative gravity in a certain place on the earth's surface. A case study on relative gravity was conducted inSemarang, especially downtown area, using a gravimeter. The point Kop. A Yani 15 in Diponegoro Park in front of St ElizabethHospital is used as the reference point. The gravity value in this point is 978099.311mGal. The relative gravity was calculated bydiscrepancy between the absolute value and corrected measured gravity. The study showes that the northern part of Semarangarea has a higher value than that of southern part. This result in line with the fact of Semarang's topography

  3. TROIS APOLOGUES RELATIFS À LA THÉORIE DU CAPITAL

    OpenAIRE

    Béraud, Alain

    2015-01-01

    International audience; On analyse, dans cette communication, trois apologues relatifs à la théorie du capital et de l'intérêt. Rae montre que, dans la formation des richesses, c’est l’innovation plutôt que la division du travail et l’accumulation du capital qui importe. Il a, d’autre part, mis en évidence la relation entre le taux de rendement et la vitesse de récupération. Mais, surtout, il affirme que l’homme est rationnel. Il a un but en vue, la satisfaction de ses besoins futurs et pour ...

  4. Perspectives d'introduction d'un marketing des services au sein des banques publiques Algériennes : Cas de la B.A.D.R.

    OpenAIRE

    Lachachi-taleb, Meriem

    2014-01-01

    Le premier chapitre présente les fondements théoriques relatifs au marketing des services ainsi qu'au concept de servuction et enfin au marketing mix des services dans le deuxiéme chapitre.Le troisiéme chapitre est consacré au marketing bancaire et au plan marketing dans le chapitre suivant, une étude de cas au sein de la B.A.D.R.Banque.

  5. Initiation à l'entomologie: Syllabus relatif au cours à distance

    OpenAIRE

    Mignon, Jacques

    2005-01-01

    Syllabus en huit chapitres correspondant aux huit modules du cours à distance "Initiation à l'entomologie" du Professeur Eric Haubruge - 1. Introduction; 2. Les appendices céphaliques; 3. Les ordres; 4. Les Hémiptères; 5. Les Lépidoptères; 6. Les Hyménoptères; 7. Les Diptères; 8. Les Coléoptères

  6. Etudes Comparatives Des Termes Anglais Et Français Relatifs Au ...

    African Journals Online (AJOL)

    French).Terms were simply assembled to make them easily accessible to television commentators with a view to saving them the task of always having recourse to the dictionary for Africa World Cup commentators. Key words: Terminology, Football ...

  7. Facteurs relatifs au faible poids de naissance à l'EHS En ...

    African Journals Online (AJOL)

    âge maternelle situé entre 20 et 34 ans, l'âge gestationnel inférieur à 37 SA, et le score d'APGAR<7, mais aussi le rôle d´autres facteurs tels que les pathologies de la mère, notamment l'hypertension artérielle, et le diabète gestationnel.

  8. Sport et politique au Senegal, de 2000 a 2012 | Loum | Journal de la ...

    African Journals Online (AJOL)

    Malgré l'existence de structures juridiques, économiques, matérielles, techniques et humaines, la promulgation de texte de lois relatifs au développement et à la promotion du sport et la mise en place de programmes d'actions dans le domaine du sport au nom des politiques sportives , force est de constater que la stratégie ...

  9. [Understanding dosage calculations].

    Science.gov (United States)

    Benlahouès, Daniel

    2016-01-01

    The calculation of dosages in paediatrics is the concern of the whole medical and paramedical team. This activity must generate a minimum of risks in order to prevent care-related adverse events. In this context, the calculation of dosages is a practice which must be understood by everyone. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  10. Compacted Solid Dosage Form

    NARCIS (Netherlands)

    Frijlink, Henderik W.; Hinrichs, Wouter; Grasmeijer, Floris

    2016-01-01

    The present invention relates to dosage forms comprising a compressed blend of a biologically active ingredient, one or more polymers like a poly(α-hydroxy carboxylic acid) in which optionally is incorporated a glass transition modifying agent, and optional further ingredients, wherein the polymer

  11. Expandable gastroretentive dosage forms.

    Science.gov (United States)

    Klausner, Eytan A; Lavy, Eran; Friedman, Michael; Hoffman, Amnon

    2003-06-24

    Expandable gastroretentive dosage forms (GRDFs) have been designed for the past 3 decades. They were originally created for possible veterinary use, but later the design was modified for enhanced drug therapy in humans. These GRDFs are easily swallowed and reach a significantly larger size in the stomach due to swelling or unfolding processes that prolong their gastric retention time (GRT). After drug release, their dimensions are minimized with subsequent evacuation from the stomach. Gastroretentivity is enhanced by the combination of substantial dimensions with high rigidity of the dosage form to withstand the peristalsis and mechanical contractility of the stomach. Positive results were obtained in preclinical and clinical studies evaluating GRT of expandable GRDFs. Narrow absorption window drugs compounded in such systems have improved in vivo absorption properties. These findings are an important step towards the implementation of expandable GRDFs in the clinical setting. The current review deals with expandable GRDFs reported in articles and patents, and describes the physiological basis of their design. Using the dog as a preclinical screening model prior to human studies, relevant imaging techniques and pharmacokinetic-pharmacodynamic aspects of such delivery systems are also discussed.

  12. Mouvement relatif de deux bulles semblables qui évoluent dans un fluide au repos, à faibles nombres de Reynolds

    Science.gov (United States)

    Candelier, Fabien

    2007-11-01

    By using an iterative approach close to the method of reflections, the relative motion of two identical bubbles rising in a fluid at rest is investigated theoretically. The classical phenomena concerning the motion of two bubbles rising in line, or the repulsion of two bubbles rising side by side are obviously recovered, but moreover, the relative motion of the two particles may be obtained whatever their initial positions, requiring that they satisfy the basis assumption made in this study. This result is therefore used in order to represent all the possible relative trajectories adopted by a particle interacting with an other one. To cite this article: F. Candelier, C. R. Mecanique 335 (2007).

  13. Endotoxin dosage in sepsis

    Directory of Open Access Journals (Sweden)

    Vincenzo Rondinelli

    2012-03-01

    Full Text Available Introduction. Endotoxin, a component of the cell wall of Gram-negative bacteria is a major contributor to the pathogenesis of septic shock and multiple organ failure (MOF. Its entry into the bloodstream stimulates monocytes/macrophages which once activated produce and release cytokines, nitric oxide and other mediators that induce systemic inflammation, endothelial damage, organ dysfunction, hypotension (shock and MOF.The aim of this study is to evaluate the usefulness of a quantitative test for the dosage of endotoxin to determine the risk of severe Gram-negative sepsis. Materials and methods. In the period January 2009 - June 2011 we performed 897 tests for 765 patients, mostly coming from the emergency room and intensive care, of which 328 (43% women (mean age 53 and 437 (57% male (mean age 49. Fifty-nine patients, no statistically significant difference in sex, were monitored by an average of two determinations of EA.All patients had procalcitonin values significantly altered.The kit used was EAA (Endotoxin Activity Assay Estor Company, Milan, which has three ranges of endotoxin activity (EA: low risk of sepsis if <0.40 units, medium if between 0.40 and 0.59; high if 0.60. Results. 78 out of 765 patients (10% had a low risk, 447 (58% a medium risk and 240 (32% a high risk.The dosage of EA, combined with that of procalcitonin, has allowed a more targeted antibiotic therapy. Six patients in serious clinical conditions were treated by direct hemoperfusion with Toraymyxin, a device comprising a housing containing a fiber polypropylene and polystyrene with surface-bound polymyxin B, an antibiotic that removes bacterial endotoxins from the blood. Conclusions.The test is useful in risk stratification as well as Gram negative sepsis, to set and monitor targeted therapies, also based on the neutralization of endotoxin.

  14. Gastroretentive dosage forms.

    Science.gov (United States)

    Moës, A J

    1993-01-01

    This article begins with a review of gastric emptying, small intestine transit, and colonic transit of drug delivery systems with special attention paid to the different physiological processes involved in stomach emptying and to the cut-off size of nondigestible solids for passage through the gastroduodenal junction during the digestive phase. Then, the proposed means for prolonging the gastric residence time (GRT) of drug delivery systems are reviewed and analyzed with special emphasis on floating (F) dosage forms. The following means are discussed: the use of passage-delaying agents, large single-unit dosage forms, bioadhesive drug delivery systems, "heavy" pellets, and buoyant forms. In the section devoted to bioadhesive forms, the influence of the turnover time of the intestinal mucus gel layer on the performance of mucoadhesive preparations is pointed out to explain the poor results obtained in humans with such peroral products. The use of a specifically designed apparatus for measuring the total force acting vertically on an object immersed in a liquid is presented as a methodology for selecting optimized buoyant formations in vitro. Scintigraphic studies are described in nonfasting human volunteers either in upright or in supine posture, who concurrently were given one optimized F and one nonfloating (NF) hydrophilic matrix capsules of the same size, for three different sizes (small, medium, and large). In upright subjects, the F forms stayed continuously above the gastric contents irrespective of their size, whereas the NF ones sank rapidly after administration and never rose back to the surface thereafter. Consequently, the F forms show prolonged and more reproducible GRTs compared to the NF ones. The significance and extent of this prolongation are the most marked for the small size units (p 0.05). Moreover, there is no significant difference between the mean GRTs of the small, medium, and large F units (p > 0.05). This indirectly confirms that the

  15. Ketahanan Relatif Enam Belas Nomor Klon Teh PGL terhadap Serangan Empoasca sp.

    Directory of Open Access Journals (Sweden)

    F.X. Wagiman

    2011-12-01

    Full Text Available The relative resistance of sixteen selected PGL tea clones against Empoasca sp. had been studied at tea estate of Pagilaran. Six selected and superior tea clones were PGL 4, 6, 9, 10, 11, 15, and ten other selected clones were PGL1, PGL2, PGL3, PGL5, PGL7, PGL8, PGL12, PGL13, PGL14, dan PGL16. Growth stage of the test tea-plants was productive stage, hence it was already infested by Empoasca sp.within several years. The study was conducted in the dry season of September 2011−November 2011, in which the climatic conditions support the increase of pest populations. Moderate level of pest populations was appropriate for conducting the research. Therefore, afdeling Pagilaran was chosen as a research site because of its moderate level of Empoasca sp. population (3.74 individuals/20 sweepnets, while in the afdeling Andongsili the population was low (1.70 individuals/20 sweepnets and in afdeling Kayulandak was too high (9.81 individuals/20 sweepnets. Resistance criterion was developed based on statistical-analysis result of the pest population. Results showed that all PGL clones were attacked by Empoasca sp. However, PGL 4 was consistently the most sensitive and PGL 15 was the most resistant, while others showed moderate resistance against the pest attack.   Ketahanan relatif enam belas nomor terpilih klon teh PGL terhadap serangan Empoasca sp. telah dikaji di kebun teh Pagilaran. Enam nomor klon terpilih dan unggul adalah PGL4, PGL6, PGL9, PGL10, PGL11, PGL15, dan 10 nomor terpilih lainnya adalah PGL1, PGL2, PGL3, PGL5, PGL7, PGL8, PGL12, PGL13, PGL14, dan PGL16. Stadia pertumbuhan tanaman teh uji adalah stadia produksi sehingga telah beberapa tahun mengalami serangan Empoasca sp. Kajian dilaksanakan dalam musim kemarau selama bulan September 2011–November 2011, ketika kondisi iklim mendukung peningkatan populasi hama ini. Tingkat populasi hama yang moderat sesuai untuk melakukan kajian. Afdeling Pagilaran dipilih sebagai arena kajian karena

  16. Liquisolid Dosage System: A Novel Approach for Dosage formulation

    OpenAIRE

    Sudarshan B. Aher; Dattatraya M. Shinkar; Ravindra B. Saudagar

    2015-01-01

    In the drug development enhancement of oral bioavailability of poorly water soluble drugs is one of the most challenging aspects of drug. The pharmaceutical industry face the problem poor dissolution characteristics of water insoluble drug. these problem solve by applying recent techniques “powdered solution technology” or “liquisolid technology”, for prepare water-insoluble drugs into rapid-release solid dosage forms. Design and formulation of this approach is prescribed according to new mat...

  17. Profil hormonal chez l'homme en cas d'infertilité au laboratoire de ...

    African Journals Online (AJOL)

    ... dans notre étude, tous les patients consultant pour infertilité datant d'au moins deux ans, avec un spermogramme anormal et dont le bilan hormonal comportait les dosages des quatre paramètres à savoir la FSH, la LH, la PRL et la Testostérone au laboratoire de radio Immuno dosages du service de médecine nucléaire.

  18. Argumentations sur les énergies renouvelables en France et au Japon

    OpenAIRE

    Sarale, Jean-Marc

    2015-01-01

    Ce travail se veut une tentative d’argumentation comparée, au sens de Plantin 2005, portant sur la relation, par la presse écrite, de débats relatifs à l’implantation d’éoliennes. Après de brèves considérations sur les objectifs et la méthodologie d’une telle argumentation comparée, il présente deux projets de développement éolien, l’un en France, l’autre au Japon, qui ont donné lieu, dans chacun des deux pays, à des controverses nourries, s’étendant sur plusieurs années. Puis il expose la co...

  19. ORALLY DISINTEGRATING TABLET: FRIENDLY DOSAGE FORM

    OpenAIRE

    Saxena Vaibhav; Khinchi Mahaveer Pr; Gupta M.K.; Agarwal Dilip; Sharma Natasha

    2010-01-01

    Orally disintegrating tablets (ODTs) have emerged as one of the popular and widely accepted dosage forms, especially for the paediatric and geriatric patients. In recent decades, a variety of pharmaceutical research has been conducted to develop new dosage forms. Among the dosage forms developed to facilitate ease of medication, the rapid disintegrating tablet (RDT) is one of the most widely employed commercial products.1 As our society is becoming increasingly aged, the development of Fast-...

  20. Pentamidine Dosage: A Base/Salt Confusion

    NARCIS (Netherlands)

    Dorlo, Thomas P. C.; Kager, Piet A.

    2008-01-01

    Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two different formulations available. Confusion on the dosage of pentamidine arose from a different labelling

  1. A brief history of dosage compensation

    Indian Academy of Sciences (India)

    ... postulated the origin of the Y chromosome as having resulted from restricted recombination between homologous sex chromosomes in the male and the accumulation of deleterious mutations. This evolutionary process leads to dosage compensation. This article lays out a brief history of dosage compensation in genetics.

  2. Dosage form design and development.

    Science.gov (United States)

    Allen, Loyd V

    2008-11-01

    Drugs must be properly formulated for administration to patients, regardless of age. Pediatric patients provide some additional challenges to the formulator in terms of compliance and therapeutic efficacy. Due to the lack of sufficient drug products for the pediatric population, the pharmaceutical industry and compounding pharmacies must develop and provide appropriate medications designed for children. The purpose of this article was to review the physical, chemical, and biological characteristics of drug substances and pharmaceutical ingredients to be used in preparing a drug product. In addition, stability, appearance, palatability, flavoring, sweetening, coloring, preservation, packaging, and storage are discussed. Information for the current article was gathered from a literature review; from presentations at professional and technical meetings; and from lectures, books, and publications of the author, as well as from his professional experience. Professional society meetings and standards-setting bodies were also used as a resource. The proper design and formulation of a dosage form requires consideration of the physical, chemical, and biological characteristics of all of the drug substances and pharmaceutical ingredients (excipients) to be used in fabricating the product. The drug and pharmaceutical materials utilized must be compatible and produce a drug product that is stable, efficacious, palatable, easy to administer, and well tolerated. Preformulation factors include physical properties such as particle size, crystalline structure, melting point, solubility, partition coefficient, dissolution, membrane permeability, dissociation constants, and drug stability. Successful development of a formulation includes multiple considerations involving the drug, excipients, compliance, storage, packaging, and stability, as well as patient considerations of taste, appearance, and palatability.

  3. Tentative d'évaluation du systéme d'information marketing au niveau des banques publiques Algériennes

    OpenAIRE

    Hassaine-kazi-tani, Amel

    2014-01-01

    Le premier chapitre présente les fondements théoriques relatifs au marketing, marketing des services et notamment le marketing bancaire.dans le deuxiéme chapitre seront développées les notions de base du concept d'information et celui de systéme d'information et puis le systéme d'information marketing.le troisiéme chapitre pratique présente une étude de cas auprés des banques publiques Algériennes.

  4. No. 614 law project relative to the energy sector; No. 614 projet de Loi relatif au secteur de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-11-15

    This law project concerns the market opening and the free choice of the consumers, the dispositions relative to the electricity and gas distribution and the dispositions relative to the Gaz De France capital and the government control. (A.L.B.)

  5. Monthly Record Tables, December 1998, with Supplement for the 4. quarter 1998; Tableaux mensuels des mesures, Decembre 1998, avec supplement relatif au 4-eme trimestre 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    This report, issued under the aegis of O.P.R.I. (Office of protection against ionizing radiations), contains the activity level measurements of the radiation monitoring units throughout the country recorded in December 1998. A supplement contains the data relative to the 4. quarter is also added. Data relative toatmospheric sampling refer to surface and high altitude air as well as to atmospheric tritium concentration at Valduc. For rain water, dry fallout and deposition at soil level weekly sampling were carried out and monthly surveillance is reported. The drinking, surface and ground water measurements are reported for nuclear and non-nuclear sites. Measurement on food chains refer to cow milk, thyroids of horned cattle and fishes in the national market. Activity levels of given radioisotopes are given for vegetables and coastal sea waters as well as for waste and rain waters. Surveillance of wastes from facilities other than basic nuclear units (hospitals, research units, etc) was measured downstream to large cities in waste waters, rivers, sediments and aquatic flora. Sanitary controls on food and environment are reported as well as those carried out on workers and on operators implied in 6 nuclear incidents without consequences which occurred in December 1998 in French NPPs. The quarterly results refer to the following 16 items: 1. Radioactivity inventory in feedwater (Calvados); 2.Drinking waters; 3.Hydro-mineral sources; 4.Sea medium at Nord-Cotentin; 5.Surveillance of major National Navy facilities; 6.Surveillance of CNPE at Gravelines; 7. Surveillance of CNPE at Civaux; 8.Surveillance of COGEMA site at Marcoule; 9.Marine fauna and flora; 10.Surveillance of rice fields at Camargue; 11.Surveillance of sea sediments in Seine mouth; 12.Controlled releases; 13.Food chains; 14.Animal bones; 15.Soils; 16.Integrating dosemeters.

  6. Areva revenue and data for the first quarter of 2008; Areva informations et chiffre d'affaires relatifs au 1. trimestre de l'exercice 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    First quarter 2008 revenue was up 12.1% year-on-year, to 2.769 billion euros. Like-for-like (at constant exchange rates and consolidation scope), growth came to 14.5%. Foreign exchange had a negative impact of 2.5%, or -69 million euros, mainly due to currency translation tied to the US dollar drop compared with the euro. The consolidation scope had a positive impact of +0.7% or 18 million euros, chiefly as a result of the consolidation of VEI Distribution (specializing in medium voltage distribution) and Passoni and Villa (world leader in the manufacture of high voltage bushings) in the Transmission and Distribution division. The main growth engines for first quarter revenue were the Reactors and Services division and the Back End division, with growth of 29.7% (+36.8% LFL1) and 13.8% (+14.1% LFL1) respectively. Outside France, revenue rose to 1.857 billion euros, compared with 1.753 billion euros in the first quarter of 2007. This represents 67% of total revenue. As a reminder, the group points out that: - revenue can vary significantly from one quarter to the next in the nuclear businesses, and quarterly operations should therefore not be taken as a reliable basis for annual projections; - the foreign exchange impact mentioned in this release comes from the translation of subsidiary accounts into the group's unit of account, and primarily reflects the US dollar in relation to the euro. AREVA also points out that its foreign exchange hedging policy for commercial operations aims to shield profitability from fluctuations in exchange rates in relation to the euro.

  7. Safety guidebook relative to the disposal of radioactive wastes in deep geologic formation; Guide de surete relatif au stockage definitif des dechets radioactifs en formation geologique profonde

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The French nuclear safety authority (ASN) initiated in 2003 a revision process of the objectives to be considered during the research and work steps of the implementation of a radioactive waste storage facility in deep geologic formations. The purpose of this document is to define the safety objectives that have to be retained at each step of this implementation, from the site characterization to the closure of the facility. This update takes into account the works carried out by the ANDRA (French national agency of radioactive wastes) in the framework of the law from December 30, 1991, and the advices of the permanent experts group about these works. It takes also into consideration the international research works in this domain and the choices defined in the program law no 2006-739 from June 28, 2006 relative to the sustainable management of radioactive materials and wastes. The main modifications concern: the notion of reversibility, the definition of the safety functions of disposal components, the safety goals and the design principles assigned to waste packages, the control of nuclear materials and the monitoring objectives of the facility. The documents treats of the following points: 1 - the objectives of public health and environment protection; 2 - the safety principles and the safety-related design bases of the facility; and 3 - the method used for demonstrating the disposal safety. (J.S.)

  8. N.3201 National Assembly law project relative to the energy sector; N.3201 Assemblee Nationale projet de loi relatif au secteur de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This law text, elaborated in the framework of the energy market deregulation, presents the market deregulation and the free choice for the consumers, the dispositions relative to the gas and electric power distribution, the dispositions relative to the Gaz de France capital and the State control and dispositions relatives to contracts of natural ags and electric power supply. (A.L.B.)

  9. Areva. Nine-month 2007 sales revenue and data; Areva. Informations et chiffre d'affaires relatifs au neuf premiers mois de l'exercice 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-10-15

    The main information concerning the nine-month 2007 financial data of the Areva group is a steady growth of 9-month sales revenue, at euro 8.066 billion (+6.8% like-for-like), including euro 2.692 billion in the 3. quarter, i.e. +7.6% like-for-like. The group confirms its strong sales revenue growth objective for 2007.

  10. 21 CFR 526.464 - Cloxacillin intramammary dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Cloxacillin intramammary dosage forms. 526.464... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.464 Cloxacillin intramammary dosage forms. ...

  11. 21 CFR 526.1696 - Penicillin intramammary dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Penicillin intramammary dosage forms. 526.1696... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS INTRAMAMMARY DOSAGE FORMS § 526.1696 Penicillin intramammary dosage forms. ...

  12. SOLID DOSAGE FORMS IN UNANI SYSTEM OF MEDICINE: AN OVERVIEW

    OpenAIRE

    Shahid S. Chaudhary; Mohd. Tariq; Roohi Zaman; Shaikh Imtiyaz

    2013-01-01

    Drugs obtained from natural sources are rarely administered or dispensed to patients in their native forms but are formulated into dosage forms. In Unani system of medicine dosage forms are broadly classified into four categories according to their state these are solid dosage forms, semisolid, liquid and gaseous dosage forms. Among them solid dosage forms e.g. Sufoof (powder), Kohal (coryllium), Kushta (calx), Qurs (tablet) etc have several advantages over other dosage forms such as higher s...

  13. Jawarish, a Persian traditional gastrointestinal dosage form.

    Science.gov (United States)

    Zargaran, Arman; Zarshenas, Mohammad M; Hosseinkhani, Ayda; Mehdizadeh, Alireza

    2012-06-01

    Medical sciences including pharmacy flourished in Persia throughout medieval times. The oldest pharmacopeias which discussed pharmaceutical formulations were created by them, called Qarabadin. Among various dosage forms which were described, Jawarish was a gastrointestinal dosage form which was made from different ingredients for different purposes such as stomach tonic, digestive, carminative, laxative, astringent, visceral analgesic, antihaemorrhoid, antiemetic, emetic, antireflux and anticolic. This paper, introduces their preparation, general considerations and five common examples of Jawarish.

  14. Prescribing Errors Involving Medication Dosage Forms

    Science.gov (United States)

    Lesar, Timothy S

    2002-01-01

    CONTEXT Prescribing errors involving medication dose formulations have been reported to occur frequently in hospitals. No systematic evaluations of the characteristics of errors related to medication dosage formulation have been performed. OBJECTIVE To quantify the characteristics, frequency, and potential adverse patient effects of prescribing errors involving medication dosage forms . DESIGN Evaluation of all detected medication prescribing errors involving or related to medication dosage forms in a 631-bed tertiary care teaching hospital. MAIN OUTCOME MEASURES Type, frequency, and potential for adverse effects of prescribing errors involving or related to medication dosage forms. RESULTS A total of 1,115 clinically significant prescribing errors involving medication dosage forms were detected during the 60-month study period. The annual number of detected errors increased throughout the study period. Detailed analysis of the 402 errors detected during the last 16 months of the study demonstrated the most common errors to be: failure to specify controlled release formulation (total of 280 cases; 69.7%) both when prescribing using the brand name (148 cases; 36.8%) and when prescribing using the generic name (132 cases; 32.8%); and prescribing controlled delivery formulations to be administered per tube (48 cases; 11.9%). The potential for adverse patient outcome was rated as potentially “fatal or severe” in 3 cases (0.7%), and “serious” in 49 cases (12.2%). Errors most commonly involved cardiovascular agents (208 cases; 51.7%). CONCLUSIONS Hospitalized patients are at risk for adverse outcomes due to prescribing errors related to inappropriate use of medication dosage forms. This information should be considered in the development of strategies to prevent adverse patient outcomes resulting from such errors. PMID:12213138

  15. Gene dosage imbalances: action, reaction, and models.

    Science.gov (United States)

    Veitia, Reiner A; Potier, Marie Claude

    2015-06-01

    Single-gene deletions, duplications, and misregulation, as well as aneuploidy, can lead to stoichiometric imbalances within macromolecular complexes and cellular networks, causing their malfunction. Such alterations can be responsible for inherited or somatic genetic disorders including Mendelian diseases, aneuploid syndromes, and cancer. We review the effects of gene dosage alterations at the transcriptomic and proteomic levels, and the various responses of the cell to counteract their effects. Furthermore, we explore several biochemical models and ideas that can provide the rationale for treatments modulating the effects of gene dosage imbalances. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. A brief history of dosage compensation

    Indian Academy of Sciences (India)

    in the female, or in Muller's terms, depression of X-linked activity in the female. The rapid acceptance of X inactivation as the underlying mechanism of mammalian dosage com- pensation was probably due to the accompanying easily visi- ble Barr body or heteropycnotic X chromosome, an accepted marker of genetic ...

  17. Mucoadhesive films as perspective oral dosage form.

    Science.gov (United States)

    Landová, Hana; Daněk, Zdeněk; Gajdziok, Jan; Vetchý, David; Stembírek, Jan

    2013-02-01

    Mucoadhesion is a specific phenomenon of creating bonds during intimate contact between biological surfaces covered by a mucus layer and a mucoadhesive material. In recent years come to the forefront of interest in the pharmaceutical industry modern dosage forms based on this specific process. Films (discs, patches) composed of mucoadhesive polymers (cellulose derivatives, polyacrylates, polyoxyethylene, etc.) prepared by established methods (solvent casting, hot melt extrusion, etc.) could be perspective candidates for oral administration of many drugs due to their flexibility and comfortable use. In addition, they can circumvent the relatively short residence time of conventional oral dosage forms on the mucosa and provide a precisely measured drug dose to the application site. Moreover, they can also help to protect the wound surface, thus help to reduce pain and improve effectiveness of the therapy. The aim of this article is to give an overview about the principles of creation of mucoadhesive bonds and about novel dosage form - mucoadhesive films in terms of their composition, preparation and practical usage. oral mucosa mucoadhesion principles mucoadhesive dosage forms films patches discs.

  18. Spectrophotometric Determination of Trimipramine in Tablet Dosage ...

    African Journals Online (AJOL)

    Purpose: To develop and validate simple, rapid and sensitive spectrophotometric procedures for determination of trimipramine in tablet dosage form. Methods: The methods were based on the interaction of trimipramine as n-electron donor with the ο-acceptor, iodine and various π-acceptors, namely: chloranil (CH), ...

  19. Estimated Maximal Safe Dosages of Tumescent Lidocaine

    Science.gov (United States)

    Jeske, Daniel R.

    2016-01-01

    BACKGROUND: Tumescent lidocaine anesthesia consists of subcutaneous injection of relatively large volumes (up to 4 L or more) of dilute lidocaine (≤1 g/L) and epinephrine (≤1 mg/L). Although tumescent lidocaine anesthesia is used for an increasing variety of surgical procedures, the maximum safe dosage is unknown. Our primary aim in this study was to measure serum lidocaine concentrations after subcutaneous administration of tumescent lidocaine with and without liposuction. Our hypotheses were that even with large doses (i.e., >30 mg/kg), serum lidocaine concentrations would be below levels associated with mild toxicity and that the concentration-time profile would be lower after liposuction than without liposuction. METHODS: Volunteers participated in 1 to 2 infiltration studies without liposuction and then one study with tumescent liposuction totally by local anesthesia. Serum lidocaine concentrations were measured at 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, and 24 hours after each tumescent lidocaine infiltration. Area under the curve (AUC∞) of the serum lidocaine concentration-time profiles and peak serum lidocaine concentrations (Cmax) were determined with and without liposuction. For any given milligram per kilogram dosage, the probability that Cmax >6 μg/mL, the threshold for mild lidocaine toxicity was estimated using tolerance interval analysis. RESULTS: In 41 tumescent infiltration procedures among 14 volunteer subjects, tumescent lidocaine dosages ranged from 19.2 to 52 mg/kg. Measured serum lidocaine concentrations were all lidocaine toxicity without liposuction at a dose of 28 mg/kg and with liposuction at a dose of 45 mg/kg was ≤1 per 2000. CONCLUSIONS: Preliminary estimates for maximum safe dosages of tumescent lidocaine are 28 mg/kg without liposuction and 45 mg/kg with liposuction. As a result of delayed systemic absorption, these dosages yield serum lidocaine concentrations below levels associated with mild toxicity and are a nonsignificant

  20. Polyelectrolyte Dosage Control System for Water Filtration,

    Science.gov (United States)

    1981-02-01

    the development of a method for the control of polyelectrolyte dosage were sug- gested. They were: " Sedimentation Potential " Turbidity Titration ... potentiometrically in accordance with Standard Method (1975) where 50 ml samples were titrated to a pH of 4.5 by addition of 0.02 N sulfuric acid. Results were...into the sample via a titration buret to give a desired concentration. (3) Water sample was allowed to mix with polyelectrolyte for 10 to 15 second

  1. Ion transport in Au doped/undoped KDP crystals with KI/NaI as ...

    Indian Academy of Sciences (India)

    Unknown

    meter (Hewlett–Packard) was used to measure capaci- tance (C) of the sample as a function of frequency. 2.2 Conductivity measurement. Both undoped and Au+ doped crystals were subjected to γ-irradiation using 60Co source to a dosage 5 Mrads. The conductivity measurements were carried out for both irradiated and ...

  2. 21 CFR 520.300 - Cambendazole oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Cambendazole oral dosage forms. 520.300 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.300 Cambendazole oral dosage forms. ...

  3. 21 CFR 520.903 - Febantel oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Febantel oral dosage forms. 520.903 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.903 Febantel oral dosage forms. ...

  4. 21 CFR 520.1720 - Phenylbutazone oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Phenylbutazone oral dosage forms. 520.1720 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1720 Phenylbutazone oral dosage forms. ...

  5. 21 CFR 520.622 - Diethylcarbamazine citrate oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Diethylcarbamazine citrate oral dosage forms. 520... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.622 Diethylcarbamazine citrate oral dosage forms. ...

  6. 21 CFR 520.2261 - Sulfamethazine sodium oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Sulfamethazine sodium oral dosage forms. 520.2261... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2261 Sulfamethazine sodium oral dosage forms. ...

  7. 21 CFR 520.445 - Chlortetracycline oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Chlortetracycline oral dosage forms. 520.445... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.445 Chlortetracycline oral dosage forms. ...

  8. 21 CFR 522.1660 - Oxytetracycline injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Oxytetracycline injectable dosage forms. 522.1660... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1660 Oxytetracycline injectable dosage forms. ...

  9. 21 CFR 520.2325 - Sulfaquinoxaline oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Sulfaquinoxaline oral dosage forms. 520.2325... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2325 Sulfaquinoxaline oral dosage forms. ...

  10. 21 CFR 520.1044 - Gentamicin sulfate oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Gentamicin sulfate oral dosage forms. 520.1044... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1044 Gentamicin sulfate oral dosage forms. ...

  11. 21 CFR 520.1450 - Morantel tartrate oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Morantel tartrate oral dosage forms. 520.1450... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1450 Morantel tartrate oral dosage forms. ...

  12. 21 CFR 520.2260 - Sulfamethazine oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Sulfamethazine oral dosage forms. 520.2260 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2260 Sulfamethazine oral dosage forms. ...

  13. 21 CFR 520.1696 - Penicillin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Penicillin oral dosage forms. 520.1696 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1696 Penicillin oral dosage forms. ...

  14. 21 CFR 520.2380 - Thiabendazole oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Thiabendazole oral dosage forms. 520.2380 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2380 Thiabendazole oral dosage forms. ...

  15. 21 CFR 520.2345 - Tetracycline oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Tetracycline oral dosage forms. 520.2345 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2345 Tetracycline oral dosage forms. ...

  16. 21 CFR 520.90 - Ampicillin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ampicillin oral dosage forms. 520.90 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.90 Ampicillin oral dosage forms. ...

  17. 21 CFR 520.2473 - Tioxidazole oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Tioxidazole oral dosage forms. 520.2473 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2473 Tioxidazole oral dosage forms. ...

  18. 21 CFR 520.45 - Albendazole oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Albendazole oral dosage forms. 520.45 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.45 Albendazole oral dosage forms. ...

  19. 21 CFR 520.905 - Fenbendazole oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Fenbendazole oral dosage forms. 520.905 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.905 Fenbendazole oral dosage forms. ...

  20. 76 FR 78815 - Oral Dosage Form New Animal Drugs; Cyclosporine

    Science.gov (United States)

    2011-12-20

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs...--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 520 continues to read as... period, the dosage may be tapered by decreasing the frequency of administration to every other day or two...

  1. 21 CFR 520.763 - Dithiazanine iodide oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Dithiazanine iodide oral dosage forms. 520.763... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.763 Dithiazanine iodide oral dosage forms. ...

  2. 21 CFR 520.2150 - Stanozolol oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Stanozolol oral dosage forms. 520.2150 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2150 Stanozolol oral dosage forms. ...

  3. 21 CFR 522.313 - Ceftiofur injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ceftiofur injectable dosage forms. 522.313 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.313 Ceftiofur injectable dosage forms. ...

  4. 21 CFR 520.2123 - Spectinomycin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Spectinomycin oral dosage forms. 520.2123 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2123 Spectinomycin oral dosage forms. ...

  5. 21 CFR 520.1242 - Levamisole hydrochloride oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride oral dosage forms. 520... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1242 Levamisole hydrochloride oral dosage forms. ...

  6. 21 CFR 520.1120 - Haloxon oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Haloxon oral dosage forms. 520.1120 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1120 Haloxon oral dosage forms. ...

  7. 21 CFR 520.2220 - Sulfadimethoxine oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Sulfadimethoxine oral dosage forms. 520.2220... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2220 Sulfadimethoxine oral dosage forms. ...

  8. 21 CFR 520.540 - Dexamethasone oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Dexamethasone oral dosage forms. 520.540 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.540 Dexamethasone oral dosage forms. ...

  9. 21 CFR 520.390 - Chloramphenicol oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Chloramphenicol oral dosage forms. 520.390 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.390 Chloramphenicol oral dosage forms. ...

  10. 21 CFR 520.88 - Amoxicillin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Amoxicillin oral dosage forms. 520.88 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.88 Amoxicillin oral dosage forms. ...

  11. 21 CFR 520.2160 - Styrylpyridinium, diethylcarbamazine oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2160 Styrylpyridinium, diethylcarbamazine oral dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Styrylpyridinium, diethylcarbamazine oral dosage...

  12. 21 CFR 520.1448 - Monensin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Monensin oral dosage forms. 520.1448 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1448 Monensin oral dosage forms. Monensin, as the base or the sodium salt, contains a minimum of 90 percent monensin...

  13. 21 CFR 520.82 - Aminopropazine fumarate oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Aminopropazine fumarate oral dosage forms. 520.82... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.82 Aminopropazine fumarate oral dosage forms. ...

  14. 21 CFR 520.154 - Bacitracin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Bacitracin oral dosage forms. 520.154 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.154 Bacitracin oral dosage forms. ...

  15. 21 CFR 520.620 - Diethylcarbamazine oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Diethylcarbamazine oral dosage forms. 520.620... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.620 Diethylcarbamazine oral dosage forms. ...

  16. 21 CFR 520.2520 - Trichlorfon oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Trichlorfon oral dosage forms. 520.2520 Section... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2520 Trichlorfon oral dosage forms. ...

  17. AU BURKINA FASO

    African Journals Online (AJOL)

    Les moyennes sur la même ligne et possédant le même indice ne diffèrent pas significativement au seuil de 5 %. ME : mélange fourrager. 10-20-30 % : pourcentage de concentré. GMQ : Gain Moyen Quotidien. L'analyse des résultats des rations. 1 et 2 montre que l'accès au pâturage permet des performances supérieures.

  18. DOSAGE DES ELEMENTS EN TRACE DES CALCAIRES AU SERVICE DE L'ARCHEOLOGIE

    Energy Technology Data Exchange (ETDEWEB)

    BLANC,A.; HOLMES,L.; HARBOTTLE,G.

    1998-05-01

    Numerous quarries in the Lutetian limestone formations of the Paris Basin provided stone for the building and the decoration of monuments from antiquity to the present. To determine the origin of stone used for masonry and sculptures in these monuments, a team of geologists and archaeologists has investigated 300 quarries and collected 2,300 samples. Petrographic and paleontologic examination of thin sections allows geologists to distinguish Lutetian limestones from Jurassic and Cretaceous limestones. Geologists also seek to formulate hypotheses regarding the origin of Lutetian limestones used for building and sculpture in the Paris region. In the search for the sources of building and sculptural stone, the analytical methods of geologists are limited because often several quarries produce the same lithofacies. A new tool is now available, however, to attack questions of provenance raised by art historians. Because limestones from different sources have distinctive patterns of trace-element concentrations, compositional analysis by neutron activation allows them to compare building or sculptural stone from one monument with stone from quarries or other monuments. This analytical method subjects a powdered limestone sample to standard neutron activation analysis procedures at Brookhaven National Laboratory. With the help of computer programs, the compositional fingerprints of Lutetian limestones can be determined and stored in a database. The limestone database contains data for approximately 2,100 samples from monuments, sculptures and quarries. It is particularly rich in samples from the Paris Basin.

  19. Foreign matter identification from solid dosage forms

    DEFF Research Database (Denmark)

    Pekka Pajander, Jari; Haugshøj, Kenneth Brian; Bjørneboe, Kathrine

    2013-01-01

    Despite the increased request for robust quality systems, the end product may contain unidentified defects or discoloured regions. The foreign matter has to be monitored, identified and its source defined in order to prevent further contamination. However, the identification task can be complicat...... confirmation of the identification. However, FT-IR can be used to obtain information on the compounds chemical structure and conformation, and ToF-SIMS provides sensitivity in cases, where the entire solid dosage form is contaminated with foreign matter....

  20. Les OPCVM actions au Maroc : mesure et analyse de performance-risque

    Directory of Open Access Journals (Sweden)

    F. El Majidi

    2017-09-01

    Full Text Available Cet article a pour objet d’élaborer des classements des OPCVM actions au Maroc sur un an et sur cinq ans selon la performance, le risque et le ratio risque rentabilité. On a utilisé les données figurant sur les tableaux des performances publiés par l’ASFIM. Les calculs des performances sur les deux horizons montrent que les classements des fonds ne se distinguent pas en termes des performances absolues et celles relatives à contrario on a constaté une instabilité dans les classements d’un horizon à un autre. Le nombre de fonds réalisant des performances sur une année est supérieur au nombre de fonds dont la performance est calculée sur cinq ans aussi bien en termes absolu qu’en termes relatif. Enfin, le classement par le ratio risque rentabilité est rigoureux, il diffère de ceux par les performances car les fonds changent de positions et se distinguent par leurs risques inhérents.

  1. The characteristics of novel dosage forms

    Directory of Open Access Journals (Sweden)

    Milić-Aškrabić Jela

    2003-01-01

    Full Text Available The objective of pharmaceutical-technological development is to find a procedure of transforming an active substance (a drug into a drug dosage form which is not only acceptable for application, but also enables the active substance to be released following administration, pursuant to therapy objectives. The aim is that the concentration of the active substance in the action location rapidly reaches a therapeutic level and maintains an approximately constant level in the course of a particular time, according to the established therapeutic goal. The primary objective is to present the active ingredient (drug in the form and concentration/quantity that enables the corresponding therapeutic response, i.e. to control the site and rate of medicinal substance release from the drug, as well as the rate at which it reaches the membranes and surfaces to which it is absorbed, while applying a common method of administration. The procedures used to achieve this goal are becoming highly complex and demanding and are aiming at sophisticated drug delivery systems and functional packaging material. Development from the existing drug molecule, through the conventional drug dosage form, to a new system of drug "delivery" (novel delivery system, can improve the drug (active substance characteristics significantly in view of compliance (acceptability by the patient, safety and efficiency. The paper presents an overview of the most important examples of pharmaceutical forms with controlled release and advanced drug "carriers".

  2. Mesomorphic Lamella Rolling of Au in Vacuum

    Directory of Open Access Journals (Sweden)

    Chen Shuei-Yuan

    2009-01-01

    Full Text Available Abstract Lamellar nanocondensates in partial epitaxy with larger-sized multiply twinned particles (MTPs or alternatively in the form of multiple-walled tubes (MWTs having nothing to do with MTP were produced by the very energetic pulse laser ablation of Au target in vacuum under specified power density and pulses. Transmission electron microscopic observations revealed (111-motif diffraction and low-angle scattering. They correspond to layer interspacing (0.241–0.192 nm and the nearest neighbor distance (ca. 0.74–0.55 nm of atom clusters within the layer, respectively, for the lamella, which shows interspacing contraction with decreasing particle size under the influence of surface stress and rolls up upon electron irradiation. The uncapped MWT has nearly concentric amorphous layers interspaced by 0.458–0.335 nm depending on dislocation distribution and becomes spherical onions for surface-area reduction upon electron dosage. Analogous to graphene-derived tubular materials, the lamella-derived MWT of Au could have pentagon–hexagon pair at its zig-zag junction and useful optoelectronic properties worthy of exploration.

  3. Enalapril dosage in progressive chronic nephropathy

    DEFF Research Database (Denmark)

    Elung-Jensen, Thomas; Heisterberg, Jens; Sonne, Jesper

    2005-01-01

    OBJECTIVE: In chronic renal failure, clearance of enalapril is reduced. Hence, a renoprotective effect may be achieved with lower doses than conventionally used. Since marked inter-patient variation in concentrations of enalaprilat has been shown in patients with renal failure despite equivalent...... dosage of enalapril, a direct comparison of the effect of high versus low plasma concentrations of enalaprilat on the progression of renal failure was undertaken. METHODS: Forty patients with a median glomerular filtration rate (GFR) of 17 (6-35) ml/min/1.73 m2 were studied in an open-label, randomised...... trial comparing patients with a high (>50 ng/ml) with patients with a low (concentration of enalaprilat. The dose of enalapril was titrated accordingly. The patients were followed for 12 months or until they needed renal replacement therapy. GFR was measured at 3-month...

  4. Au pair trajectories

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2015-01-01

    Since 2000, thousands of young Filipino migrants have come to Denmark as au pairs. Officially, they are there to “broaden their cultural horizons” by living temporarily with a Danish host family, but they also conduct domestic labor in exchange for food and money, which allows them to send...

  5. Catalytic activity of Au nanoparticles

    DEFF Research Database (Denmark)

    Larsen, Britt Hvolbæk; Janssens, Ton V.W.; Clausen, Bjerne

    2007-01-01

    Au is usually viewed as an inert metal, but surprisingly it has been found that Au nanoparticles less than 3–5 nm in diameter are catalytically active for several chemical reactions. We discuss the origin of this effect, focusing on the way in which the chemical activity of Au may change with par......Au is usually viewed as an inert metal, but surprisingly it has been found that Au nanoparticles less than 3–5 nm in diameter are catalytically active for several chemical reactions. We discuss the origin of this effect, focusing on the way in which the chemical activity of Au may change...... with particle size. We find that the fraction of low-coordinated Au atoms scales approximately with the catalytic activity, suggesting that atoms on the corners and edges of Au nanoparticles are the active sites. This effect is explained using density functional calculations....

  6. 21 CFR 522.1222 - Ketamine hydrochloride injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ketamine hydrochloride injectable dosage forms. 522.1222 Section 522.1222 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... ANIMAL DRUGS § 522.1222 Ketamine hydrochloride injectable dosage forms. ...

  7. 75 FR 54492 - Oral Dosage Form New Animal Drugs; Tiamulin

    Science.gov (United States)

    2010-09-08

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Tiamulin...--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 520 continues to read as...

  8. 75 FR 76259 - Oral Dosage Form New Animal Drugs; Tylosin

    Science.gov (United States)

    2010-12-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Tylosin... for Veterinary Medicine, 21 CFR part 520 is amended as follows: PART 520--ORAL DOSAGE FORM NEW ANIMAL...

  9. 77 FR 15961 - Oral Dosage Form New Animal Drugs; Phenylpropanolamine

    Science.gov (United States)

    2012-03-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs... as follows: PART 520--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part...

  10. 21 CFR 520.970 - Flunixin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Flunixin oral dosage forms. 520.970 Section 520.970 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.970 Flunixin oral...

  11. Reduced dosages of atrazine and narrow rows can provide ...

    African Journals Online (AJOL)

    An on-farm experiment was conducted in Zanyokwe irrigation scheme to investigate the effects of row spacing (45 and 90 cm) and atrazine dosage (33, 67 and 100% of the label recommended dosage) on weed density and biomass and on maize yield. Overall percent kill of weeds increased with increase in atrazine ...

  12. Lubricants in Pharmaceutical Solid Dosage Forms

    Directory of Open Access Journals (Sweden)

    Jinjiang Li

    2014-02-01

    Full Text Available Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in general, lubricants do not gain adequate attention in the development of pharmaceutical formulations. In this paper, the fundamental background on lubrication is introduced, in which the relationships between lubrication and friction/adhesion forces are discussed. Then, the application of lubrication in the development of pharmaceutical products and manufacturing processes is discussed with an emphasis on magnesium stearate. In particular, the effect of its hydration state (anhydrate, monohydrate, dihydrate, and trihydrate and its powder characteristics on lubrication efficiency, as well as product and process performance is summarized. In addition, the impact of lubrication on the dynamics of compaction/compression processes and on the mechanical properties of compacts/tablets is presented. Furthermore, the online monitoring of magnesium stearate in a blending process is briefly mentioned. Finally, the chemical compatibility of active pharmaceutical ingredient (API with magnesium stearate and its reactive impurities is reviewed with examples from the literature illustrating the various reaction mechanisms involved.

  13. Mise au point

    African Journals Online (AJOL)

    31 mai 2013 ... laryngocèle interne. Une surinfection a été notée chez trois patients réalisant ainsi le tableau de pyolaryngocèle. Tous les patients ont eu un examen clinique complet comportant un examen OrL et cervico-facial ainsi qu'un examen laryngé au ... pas en communication avec la lumière laryngée. La taille.

  14. Le CRDI au Mali

    International Development Research Centre (IDRC) Digital Library (Canada)

    sur la sécurité alimentaire internationale. Le CRDI continue de soutenir des travaux de recherche au Mali, quoique dans une moindre mesure en raison de la .... souvent tenues à l'écart du processus décisionnel. Les chercheurs tentent de déterminer de quelles manières les jeunes femmes du Mali et des pays avoisinants ...

  15. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... Le carcinome folliculaire est la deuxième tumeur maligne la plus fréquente de la thyroïde et l'invasion hématologique est le moyen de propagation le plus courant de ses métastases. Les localisations secondaires à ces cancers siègent principalement au niveau des poumons, suivi par les localisations.

  16. Le CRDI au Maroc

    International Development Research Centre (IDRC) Digital Library (Canada)

    visant à aider les secteurs de l'agriculture et du tourisme à s'adapter aux changements climatiques. Dans le cadre de recherches antérieures sur la mise au point .... France. Les manifestations et protestations survenues après 2010 et auxquelles on a donné le nom de Printemps arabe ont été annonciatrices de profondes ...

  17. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... EPIdEMIOlOgIE ET ETIOPAThOgENIE. Les angiodysplasies osseuses des maxillaires sont rares. Les premiers cas rapportés sont ceux de Berard qui a décrit en 1842 une localisation au niveau du maxillaire supérieur et de Stanley qui a rapporté en 1849 une loca- lisation mandibulaire. une prédisposition ...

  18. Le CRDI au Kenya

    International Development Research Centre (IDRC) Digital Library (Canada)

    et de l'agriculture. En produisant des connaissances dans ces secteurs essentiels, le programme contribuera à la sécurité alimentaire et améliorera la santé au Kenya. Les noms et les frontières indiqués sur la carte n'impliquent ni reconnaissance ni acceptation officielle de la part du CRDI. C. U. R. T. C. A. R. N. EM. A. R. K.

  19. Targeting determinants of dosage compensation in Drosophila.

    Directory of Open Access Journals (Sweden)

    2006-02-01

    Full Text Available The dosage compensation complex (DCC in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females. Visualization of the DCC, a large ribonucleoprotein complex, on male larval polytene chromosomes reveals that the complex binds selectively to many interbands on the X chromosome. The targeting of the DCC is thought to be in part determined by DNA sequences that are enriched on the X. So far, lack of knowledge about DCC binding sites has prevented the identification of sequence determinants. Only three binding sites have been identified to date, but analysis of their DNA sequence did not allow the prediction of further binding sites. We have used chromatin immunoprecipitation to identify a number of new DCC binding fragments and characterized them in vivo by visualizing DCC binding to autosomal insertions of these fragments, and we have demonstrated that they possess a wide range of potential to recruit the DCC. By varying the in vivo concentration of the DCC, we provide evidence that this range of recruitment potential is due to differences in affinity of the complex to these sites. We were also able to establish that DCC binding to ectopic high-affinity sites can allow nearby low-affinity sites to recruit the complex. Using the sequences of the newly identified and previously characterized binding fragments, we have uncovered a number of short sequence motifs, which in combination may contribute to DCC recruitment. Our findings suggest that the DCC is recruited to the X via a number of binding sites of decreasing affinities, and that the presence of high- and moderate-affinity sites on the X may ensure that lower-affinity sites are occupied in a context-dependent manner. Our bioinformatics analysis suggests that DCC binding sites may be composed of variable combinations of degenerate motifs.

  20. Gastroretentive dosage forms: overview and special case of Helicobacter pylori.

    Science.gov (United States)

    Bardonnet, P L; Faivre, V; Pugh, W J; Piffaretti, J C; Falson, F

    2006-03-10

    The challenge to develop efficient gastroretentive dosage forms began about 20 years ago, following the discovery of Helicobacter pylori by Warren and Marshall. In order to understand the real difficulty of increasing the gastric residence time of a dosage form, we have first summarized the important physiologic parameters, which act upon the gastric residence time. Afterwards, we have reviewed the different drug delivery systems designed until now, i.e. high-density, intragastric floating, expandable, superporous hydrogel, mucoadhesive and magnetic systems. Finally, we have focused on gastroretentive dosage forms especially designed against H. pylori, including specific targeting systems against this bacterium.

  1. Profil hormonal chez l'homme en cas d'infertilité au laboratoire de ...

    African Journals Online (AJOL)

    D. Moussa

    3 août 2016 ... Objectif : le but de l'étude est de déterminer les paramètres sociodémographiques et le profil hormonal de l'homme ... d'au moins deux ans, avec un spermogramme anormal et dont le bilan hormonal comportait les dosages des quatre ... la santé (OMS) comme étant l'absence de grossesse chez un cou-.

  2. Mise au point

    African Journals Online (AJOL)

    31 mai 2013 ... L'attitude théra- peutique dépend du type de la laryngocèle. en effet, le traitement endoscopique au laser CO2 a gagné beaucoup d'intérêt ces dernières années. MATÉRIEL ET MÉTHOdES. Il s'agit d'une étude rétrospective portant sur 9 patients porteurs d'une laryngocèle colligés sur une période de 14.

  3. Le CRDI au Ghana

    International Development Research Centre (IDRC) Digital Library (Canada)

    poussée en mathématiques aux spécialistes de demain afin qu'ils puissent relever les défis pressants qui se posent en matière d'environnement, de santé et d'économie. La bourse de chercheur invité que le CRDI a octroyée en 2001 au regretté. John Atta-Mills, qui a par la suite été prési- dent du Ghana de 2009 à 2012, ...

  4. Au pairs on Facebook

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2016-01-01

    Ethnographers are increasingly making use of Facebook to acquire access and general acquaintance with their field of study. However, little has been written on how Facebook is used methodologically in research that does not have social media sites as the main focus of interest. This article argues...... that engagement with Facebook as a methodological tool can be useful in research among migrants in highly politicised fields. Pointing to a discursive construction of Filipina au pairs as victims of labour exploitation, the article shows how fieldwork on Facebook enables the exploration of the ways in which...... and on Facebook....

  5. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... acquis et des anomalies génétiques associées ont été aussi incriminés (mutation du gène Fas ou de la p53, délétion au niveau du chromosome 6q, méthylation excessive de la p73) (15,16). Le mode de révélation de ces lymphomes est peu spéci- fique et parfois banal. L'obstruction nasale représente le.

  6. 21 CFR 522.1662 - Oxytetracycline hydrochloride implantation or injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... injectable dosage forms. 522.1662 Section 522.1662 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1662 Oxytetracycline hydrochloride implantation or injectable dosage forms. ...

  7. Integrated effect of seeding rate, herbicide dosage and application ...

    African Journals Online (AJOL)

    Integrated effect of seeding rate, herbicide dosage and application timing on durum wheat ( Triticum turgidum l. var durum) yield, yield components and wild oat (avena fatua l.) control in south eastern Ethiopia.

  8. Automatic identification and normalization of dosage forms in drug monographs

    Science.gov (United States)

    2012-01-01

    Background Each day, millions of health consumers seek drug-related information on the Web. Despite some efforts in linking related resources, drug information is largely scattered in a wide variety of websites of different quality and credibility. Methods As a step toward providing users with integrated access to multiple trustworthy drug resources, we aim to develop a method capable of identifying drug's dosage form information in addition to drug name recognition. We developed rules and patterns for identifying dosage forms from different sections of full-text drug monographs, and subsequently normalized them to standardized RxNorm dosage forms. Results Our method represents a significant improvement compared with a baseline lookup approach, achieving overall macro-averaged Precision of 80%, Recall of 98%, and F-Measure of 85%. Conclusions We successfully developed an automatic approach for drug dosage form identification, which is critical for building links between different drug-related resources. PMID:22336431

  9. Microbial quality of some herbal solid dosage forms | Enayatifard ...

    African Journals Online (AJOL)

    . This is due to raw materials contamination and unhygienic production conditions. In this study, microbiological quality of some herbal solid dosage forms from public markets, in the city of Sari, Iran was examined. 20 herbal products as tablet, ...

  10. Fourteen days oral administration of therapeutic dosage of some ...

    African Journals Online (AJOL)

    Fourteen days oral administration of therapeutic dosage of some antibiotics reduced serum testosterone in male rats. FO Awobajo, Y Raji, II Olatunji-Bello, FT Kunle-Alabi, AO Adesanya, TO Awobajo ...

  11. Buccal Dosage Forms: General Considerations for Pediatric Patients.

    Science.gov (United States)

    Montero-Padilla, Soledad; Velaga, Sitaram; Morales, Javier O

    2017-02-01

    The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives.

  12. Charged particle density distributions in Au+ Au collisions at ...

    Indian Academy of Sciences (India)

    ... measured in Au + Au collisions using the BRAHMS detector at RHIC. The results are presented as a function of the collision centrality and the center of mass energy. They are compared to the predictions of different parton scattering models and the important role of hard scattering processes at RHIC energies is discussed ...

  13. Evaluation of students' knowledge about paediatric dosage calculations.

    Science.gov (United States)

    Özyazıcıoğlu, Nurcan; Aydın, Ayla İrem; Sürenler, Semra; Çinar, Hava Gökdere; Yılmaz, Dilek; Arkan, Burcu; Tunç, Gülseren Çıtak

    2017-09-19

    Medication errors are common and may jeopardize the patient safety. As paediatric dosages are calculated based on the child's age and weight, risk of error in dosage calculations is increasing. In paediatric patients, overdose drug prescribed regardless of the child's weight, age and clinical picture may lead to excessive toxicity and mortalities while low doses may delay the treatment. This study was carried out to evaluate the knowledge of nursing students about paediatric dosage calculations. This research, which is of retrospective type, covers a population consisting of all the 3rd grade students at the bachelor's degree in May, 2015 (148 students). Drug dose calculation questions in exam papers including 3 open ended questions on dosage calculation problems, addressing 5 variables were distributed to the students and their responses were evaluated by the researchers. In the evaluation of the data, figures and percentage distribution were calculated and Spearman correlation analysis was applied. Exam question on the dosage calculation based on child's age, which is the most common method in paediatrics, and which ensures right dosages and drug dilution was answered correctly by 87.1% of the students while 9.5% answered it wrong and 3.4% left it blank. 69.6% of the students was successful in finding the safe dose range, and 79.1% in finding the right ratio/proportion. 65.5% of the answers with regard to Ml/dzy calculation were correct. Moreover, student's four operation skills were assessed and 68.2% of the students were determined to have found the correct answer. When the relation among the questions on medication was examined, a significant relation (correlation) was determined between them. It is seen that in dosage calculations, the students failed mostly in calculating ml/dzy (decimal). This result means that as dosage calculations are based on decimal values, calculations may be ten times erroneous when the decimal point is placed wrongly. Moreover, it

  14. A benefit/risk approach towards selecting appropriate pharmaceutical dosage forms - an application for paediatric dosage form selection.

    Science.gov (United States)

    Sam, Tom; Ernest, Terry B; Walsh, Jennifer; Williams, Julie L

    2012-10-05

    The design and selection of new pharmaceutical dosage forms involves the careful consideration and balancing of a quality target product profile against technical challenges and development feasibility. Paediatric dosage forms present particular complexity due to the diverse patient population, patient compliance challenges and safety considerations of this vulnerable population. This paper presents a structured framework for assessing the comparative benefits and risks of different pharmaceutical design options against pre-determined criteria relating to (1) efficacy, (2) safety and (3) patient access. This benefit/risk framework has then been applied to three hypothetical, but realistic, scenarios for paediatric dosage forms in order to explore its utility in guiding dosage form design and formulation selection. The approach allows a rigorous, systematic and qualitative assessment of the merits and disadvantages of each dosage form option and helps identify mitigating strategies to modify risk. The application of a weighting and scoring system to the criteria depending on the specific case could further refine the analysis and aid decision-making. In this paper, one case study is scored for illustrative purposes. However, it is acknowledged that in real development scenarios, the generation of actual data considering the very specific situation for the patient/product/developer would come into play to drive decisions on the most appropriate dosage form strategy. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Magnetoresistance of Au films

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, D. L., E-mail: zhangdl@iphy.ac.cn; Song, X. H.; Zhang, X. [Institute of Physics, Chinese Academy of Sciences, Beijing 10081 (China); Zhang, X.-G., E-mail: xgz@ufl.edu [Department of Physics and Quantum Theory Project, University of Florida, Gainesville, Florida 32611 (United States); Center for Nanophase Materials Sciences and Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6493 (United States)

    2014-12-14

    Classical magnetoresistance (MR) in nonmagnetic metals are conventionally understood in terms of the Kohler rule, with violation usually viewed as anomalous electron transport, in particular, as evidence of non-Fermi liquid behavior. Measurement of the MR of Au films as a function of temperature and film thickness reveals a strong dependence on grain size distribution and clear violation of the Kohler rule. Using a model of random resistor network, we show that this result can be explained if the MR arises entirely from inhomogeneity due to grain boundary scattering and thermal activation of grain boundary atoms. Consequently, the Kohler rule should not be used to distinguish normal and anomalous electron transport in solids.

  16. Parental genome dosage imbalance deregulates imprinting in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Pauline E Jullien

    2010-03-01

    Full Text Available In mammals and in plants, parental genome dosage imbalance deregulates embryo growth and might be involved in reproductive isolation between emerging new species. Increased dosage of maternal genomes represses growth while an increased dosage of paternal genomes has the opposite effect. These observations led to the discovery of imprinted genes, which are expressed by a single parental allele. It was further proposed in the frame of the parental conflict theory that parental genome imbalances are directly mirrored by antagonistic regulations of imprinted genes encoding maternal growth inhibitors and paternal growth enhancers. However these hypotheses were never tested directly. Here, we investigated the effect of parental genome imbalance on the expression of Arabidopsis imprinted genes FERTILIZATION INDEPENDENT SEED2 (FIS2 and FLOWERING WAGENINGEN (FWA controlled by DNA methylation, and MEDEA (MEA and PHERES1 (PHE1 controlled by histone methylation. Genome dosage imbalance deregulated the expression of FIS2 and PHE1 in an antagonistic manner. In addition increased dosage of inactive alleles caused a loss of imprinting of FIS2 and MEA. Although FIS2 controls histone methylation, which represses MEA and PHE1 expression, the changes of PHE1 and MEA expression could not be fully accounted for by the corresponding fluctuations of FIS2 expression. Our results show that parental genome dosage imbalance deregulates imprinting using mechanisms, which are independent from known regulators of imprinting. The complexity of the network of regulations between expressed and silenced alleles of imprinted genes activated in response to parental dosage imbalance does not support simple models derived from the parental conflict hypothesis.

  17. Parental genome dosage imbalance deregulates imprinting in Arabidopsis.

    Science.gov (United States)

    Jullien, Pauline E; Berger, Frédéric

    2010-03-19

    In mammals and in plants, parental genome dosage imbalance deregulates embryo growth and might be involved in reproductive isolation between emerging new species. Increased dosage of maternal genomes represses growth while an increased dosage of paternal genomes has the opposite effect. These observations led to the discovery of imprinted genes, which are expressed by a single parental allele. It was further proposed in the frame of the parental conflict theory that parental genome imbalances are directly mirrored by antagonistic regulations of imprinted genes encoding maternal growth inhibitors and paternal growth enhancers. However these hypotheses were never tested directly. Here, we investigated the effect of parental genome imbalance on the expression of Arabidopsis imprinted genes FERTILIZATION INDEPENDENT SEED2 (FIS2) and FLOWERING WAGENINGEN (FWA) controlled by DNA methylation, and MEDEA (MEA) and PHERES1 (PHE1) controlled by histone methylation. Genome dosage imbalance deregulated the expression of FIS2 and PHE1 in an antagonistic manner. In addition increased dosage of inactive alleles caused a loss of imprinting of FIS2 and MEA. Although FIS2 controls histone methylation, which represses MEA and PHE1 expression, the changes of PHE1 and MEA expression could not be fully accounted for by the corresponding fluctuations of FIS2 expression. Our results show that parental genome dosage imbalance deregulates imprinting using mechanisms, which are independent from known regulators of imprinting. The complexity of the network of regulations between expressed and silenced alleles of imprinted genes activated in response to parental dosage imbalance does not support simple models derived from the parental conflict hypothesis.

  18. Colons, minorités, immigrés... : Une analyse des luttes de nomination des populations minoritaires consécutives au transfert du droit européen sur les minorités en Lettonie

    OpenAIRE

    Bonnard, Pascal

    2011-01-01

    L'analyse des prises de position des députés du Parlement letton lors des débats relatifs à la ratification de la Convention-cadre pour la protection des minorités nationales permet d'interroger les usages du droit en vue de définir les minorités en tant que groupes et de déterminer leur statut au sein de la société. Le transfert du droit européen sur les minorités a suscité une modification de la désignation des populations minoritaires et de la politique à leur égard : on observe le bascule...

  19. Multifragmentation in Au + Au collisions studied with AMD-V

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Akira [Tohoku Univ., Sendai (Japan). Faculty of Science

    1998-07-01

    AMD-V is an optimum model for calculation of multifragmentation in Au + Au collisions. AMD-V consider anti-symmetry of incident nucleus, target nucleus and fragments, furthermore, it treat the quantum effect to exist many channels in the intermediate and final state. 150 and 250 MeV/nucleon incident energy were used in the experiments. The data of multifragment atom in {sup 197}Au + {sup 197}Au collisions was reproduced by AMD-V calculation using Gognny force, corresponding to the imcompressibility of nuclear substance K = 228 MeV and its mean field depend on momentum. When other interaction (SKG 2 force, corresponding to K = 373 KeV) was used an mean field does not depend on momentum, the calculation results could not reproduce the experimental values, because nucleus and deuteron were estimated too large and {alpha}-particle and intermediate fragments estimated too small. (S.Y.)

  20. Guide relative to the regulatory requirements applicable to the radioactive materials transport in airport area; Guide relatif aux exigences reglementaires applicables au transport des matieres radioactives en zone aeroportuaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-02-15

    This guide makes an inventory of all the points necessary for the correct functioning of the transport of radioactive materials in airport zone. Stowage of the parcels, program of radiological protection (P.R.P.), operation of transport, quality assurance, radiation dose evaluation, radiation monitoring, dose optimization, storage management, are the principal points of this guide. (N.C.)

  1. No. 3398 law project modified by the Senate relative to the energy sector; No. 3398 projet de Loi modifie par le Senat relatif au secteur de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-10-15

    This law project concerns the market opening and the free choice of the consumers, the dispositions relative to the electricity and gas distribution and the dispositions relative to the Gaz De France capital and the government control. (A.L.B.)

  2. On the bill on modernization and development of electricity public service; Le projet de loi relatif a la modernisation et au developpement du service public de l'electricite (no. 1253)

    Energy Technology Data Exchange (ETDEWEB)

    Dumont, Jean-Louis [ed.] [Commission des Finances, de l' Economie generale et du Plan, Assemblee Nationale, Paris (France)

    1999-02-10

    This document is a report presented on behalf of Commission of Finances, General Economy and Planning of the French National Assembly about the bill on modernization and development of electricity public service. The report contains four parts. The first part is titled 'Reinforcing the independence of the management of transport public network'. The questions of independence of EDF and the autonomy of the grid management are addressed. Also, the issue of the transparency of the transport public network management is presented. The second part discusses the means of ensuring an efficient regulation of electricity market. The missions of the Electricity Regulation Commission (CRE) are presented in connection with tariff establishment, multi-annual investment planning and consulting role of CRE. CRE's role in arbitrating the conflicts and the endorsement of the judge of public service as well as the harmonizing the competences of CRE and Competition Council are also showed. The efficiency of regulation as resulting from a consolidated independence of CRE is demonstrated. The third part concerns reinforcing the electricity public service. The principles of electricity public service are exposed as well as requirements for increasing transparency in financing the public service obligations. The forth part concerns the ways of encouraging the participation of local communities in the organization of electric sector. The issues relating to mixed organization of electricity distribution, its modernization and the role of local communities with respect to supply distribution and environment protection are exposed.

  3. Revamping and Expanding Domestic Electricity Supply. Law draft adopted by the National Assembly; Projet de Loi relatif a la Modernisation et au Developpement du Service Public de l'Electricite adopte par l'Assemblee Nationale

    Energy Technology Data Exchange (ETDEWEB)

    National Assembly [ed.] [Assemblee Nationale, Paris (France)

    1999-03-02

    This document presents the draft of the law regarding the revamping and expanding the domestic electricity supply, adopted by the French National Assembly. The first Title devoted to the definition of the domestic electricity supply contains 5 articles. The second Title deals with the production of electricity in the articles 6 through 12. Title three concerns the transport and electricity distribution issue exposed in articles 13 through 21 and three chapters titled: - Chap. 1, Transport of electricity; - Chap. 2, Distribution of electricity; - Chap.3, Safety and security of the grids. The Title four concerns with the access to domestic electricity grids exposed in the articles 22 to 24. The fifth Title settles in articles 25 to 27 the issue of the dissociation and transparency of accounting. The articles 28 through 41 treat under Title six the problems of Regulation. The Object of Electricity Authority of France is stipulated in the Title seven containing only the article 42. Social issues are stipulated in Title eight containing two articles, the first one being a completion to Chapter III of the Title seven in the Labour Law, titled 'Electricity and Gas Industries'. Finally, the Title nine comprising articles 45 to 52 deals with Diverse and Transient Provisions. The law draft was debated in public session in Paris on 2 March and signed by the President Laurent Fabius.

  4. Decree of the 7. august 2008 relative to the risk management in relation with radon in workplaces; Arrete du 7 aout 2008 relatif a la gestion du risque lie au radon dans les lieux de travail

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    This order clarifies measures to be taken in the companies where the level of radon activities involve the health of the personnel: measurements to make regularly, measures to reduce the levels of activity, to assure the dosimetry follow-up, to verify the conditions of work places, the installations of ventilation. (N.C.)

  5. The limited worldwide opening of the electric power sector: from States pre-eminence to the relative comeback of the Centre; La mondialisation limitee du secteur electrique: de la preeminence des Etats au retour relatif du Centre

    Energy Technology Data Exchange (ETDEWEB)

    Ruet, J.

    2002-07-01

    There are at least two reasons for undertaking a study of the political economy of India's electrical sector. Given that it is placed under the joint responsibility of the Centre and the States, its evolution reflects the relations between these two levels of the Indian federal system. Besides, the recent implementation of guidelines which have found favour with a large number of foreign countries could camouflage a subtle relationship with globalization which, in the case of India, is determined largely by the power equations within the country. Indeed, the reform path chosen integrates two elements: the argument that reforms have become necessary on account of the inefficiency of public sector organisations whose modes of functioning are inherited from the Indian bureaucratic system; secondly, there are political and economic forces who demand reforms as an essential element of their political strategy. In particular, contrary to the classical view in India that with liberalization there has been an emancipation of the States with regard to the Centre and the creation of expanding markets for foreign investments, the 'globalization' of the electricity sector, understood here as the opening up to the foreign private sector, could in reality be equated to a relative strengthening of the Centre vis-a-vis the States. It could also turn out to be to the advantage of some very local components, such as consumers' associations, whether rural or of local communities. (author)

  6. Project of law relative to the electricity and gas public utilities and to the power and gas companies; Projet de loi relatif au service public de l'electricite et du gaz et aux entreprises electriques et gazieres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This document is the definitive text of this project of law adopted by the French house of commons. The aim of this law is to allow the administrations to avoid to use their eligibility right with the opening of the electricity and gas markets to competition. It changes the juridical status of the two public utilities Electricite de France (EdF) and Gaz de France (GdF) into two anonymous companies and creates two additional companies for the management of the power and gas networks. It ensures also the transposition of the European directives from June 26, 2003 (2003/54/CE and 2003/55/CE). It contains some proper dispositions and modifies various existing French laws, in particular the law no. 46-628 from April 8, 1946 about the electricity and gas nationalization and the law no. 2000-108 from February 10, 2000 relative to the modernization and development of the electric public utility. (J.S.)

  7. Report on behalf of the Economic Affairs and Plan Commission on the law project relative to the energy markets; Rapport au nom de la commission des affaires economiques et du plan sur le projet de loi relatif aux marches energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-01

    In the framework of the directive no. 98/30 concerning the common rules for the natural gas internal market, the Senate debates on the law project relative to the energy markets no. 406, adopted by the Minister Council the 25 september 2002. This project transposes the directive content in french law. This document presents the amendments allowing the directive transposition. (A.L.B.)

  8. Revamping and Expanding Domestic Electricity Supply. Law draft modified by the Senate; Projet de Loi relatif a la Modernisation et au Developpement du Service Public de l'Electricite modifie par le senat

    Energy Technology Data Exchange (ETDEWEB)

    National Assembly [ed.] [Assemblee Nationale, Paris (France)

    1999-10-07

    This document presents the draft of the law (TA no. 2) modified by the French Senate regarding the revamping and expanding the domestic electricity supply. The first Title, devoted to the definition of the domestic electricity supply, contains 5 articles. The second Title deals along articles 6 through 12 with the production of electricity. Title three concerns the transport and electricity distribution issue exposed in articles 13 through 21 and three chapters titled: - Chap. 1, Transport of electricity; - Chap. 2, Distribution of electricity; - Chap.3, Safety and security of the grids. The Title four is devoted to the access to domestic electricity grids exposed in the articles 22 through 24. The fifth Title settles in articles 25 through 27 the issue of the dissociation and transparency of accounting. The articles 28 through 41 treat under Title six the problems of Regulation. The Object of Electricity Authority of France is stipulated in the Title seven containing only the article 42. Social issues are stipulated in Title eight containing two articles, the first one being a completion to Chapter III of the Title seven in the Labour Law, titled 'Electricity and Gas Industries'. Finally, the Title nine comprising articles 45 to 52 deals with Diverse and Transitory Provisions. This law draft was debated in public seance in Paris on 7 October 1999 and signed by the President Christian Poncelet.

  9. Draft of law relating to revamping of natural gas supply public service and to development of gas enterprises; Avant projet de loi relatif a la modernisation du service public du gaz naturel et au developpement des entreprises gazieres

    Energy Technology Data Exchange (ETDEWEB)

    Bricq [ed.] [Deputee de Seine-et-Marne, Assemblee Nationale, Paris (France)

    2000-02-07

    The state secretariat for industry has launched a large public debate between June and October 1999 based on a white book titled 'Towards the future organization of the gas sector'. The suggestions obtained were substantial. A brief presentation is added to the draft of the law devoted to revamping of natural gas supply public service and to development of gas enterprises. The presentation addresses the following points: 1. A public gas supply service modern and thought to reconcile the dynamism, equity and solidarity. 2. A controlled opening of the natural gas market towards competition: participating to the struggle for employment. 3. Tools ensuring the quality of gas supply and security of resources. 4. A transparent and efficient regulation: creating the conditions of a nondiscriminatory competition. 5. Requirements for developing the transport of natural gas regime. 6. Storage. 7. Social questions. The draft of the law relating to revamping of natural gas supply public service and to development of gas enterprises is a working document, not engaging the government. It is based on six titles. Title 1 and Title 2 treat the points 1 and 2 mentioned above. Title 3 contains two chapters devoted to transparency and accounting dissociation and to regulation in the natural gas sector, respectively. The Title 4 contains three chapters devoted to: 1. authorization of the works of natural gas transport; 2. gas distribution and 3. exploitation of the transport and natural gas distribution network. The fifth Title is dedicated to underground storage. The sixth Title presents diverse directives.

  10. Report relative to the radiotherapy accident occurred at the C.H.U. of Toulouse - Rangueil hospital; Rapport relatif a l'incident de radiotherapie survenu au CHU de Toulouse - Hopital de Rangueil

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-05-15

    A defect of calibration of accelerator used for the radiotherapy pulls an uncertainty on 145 patients treated since the starting of the device. It appears after calculation that the volume(of sane organs) concerned by a overdose are only for six cases. It is difficult to know from these data if a sanitary effect can occur the volume irradiated being very low. The manufacturer of the device who detected an abnormality in the files of calibration warns the hospital on April 17., 2007, the hospital stops the functioning of the device on April 18., on April 20. the declaration)of the event arrives at the division of the Asn of Bordeaux. The D.D.A.S.S. of Haute-Garonne and the regional agency of hospitalization (A.R.H.) of south Pyrenees were contacted by the division of Bordeaux. Patients are informed their files will be given to I.R.S.N. for a study concerning eventual side effects. The institute of sanitary surveillance will realize a follow up of the patients concerned and has to propose a protocol of epidemiological surveillance that will be on a two years period that corresponds to the delay of side effects appearance after this kind of treatment. (N.C.)

  11. 21 CFR 500.26 - Timed-release dosage form drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Timed-release dosage form drugs. 500.26 Section... Timed-release dosage form drugs. (a) Drugs are being offered in dosage forms that are designed to... 201(v) of the Federal Food, Drug, and Cosmetic Act. (b) Timed-release dosage form animal drugs that...

  12. Face au risque

    CERN Document Server

    Grosse, Christian; November, Valérie

    2007-01-01

    Ce volume collectif sur le risque inaugure la collection L'ÉQUINOXE. Ancré dans l'histoire pour mesurer les continuités et les ruptures, il illustre la manière dont les sciences humaines évaluent et mesurent les enjeux collectifs du risque sur les plans politiques, scientifiques, énergétiques, juridiques et éthiques. Puisse-t-il nourrir la réflexion sur la culture et la prévention du risque. Ses formes épidémiques, écologiques, sociales, terroristes et militaires nourrissent les peurs actuelles, structurent les projets sécuritaires et constituent - sans doute - les défis majeurs à notre modernité. Dans la foulée de la richesse scientifique d'Equinoxe, L'ÉQUINOXE hérite de son esprit en prenant à son tour le pari de contribuer - non sans risque - à enrichir en Suisse romande et ailleurs le champ éditorial des sciences humaines dont notre société a besoin pour forger ses repères. Après Face au risque suivra cet automne Du sens des Lumières. (MICHEL PORRET Professeur Ordinaire à la F...

  13. SPECTROPHOTOMETRIC ESTIMATION OF GEMFIBROZIL IN BULK AND PHARMACEUTICAL DOSAGE FORMS

    OpenAIRE

    Parikh Vikas C.; Karkhanis V.V

    2011-01-01

    A simple, sensitive and accurate UV spectrophotometric method has been developed for the determination of Gemfibrozil in bulk and pharmaceutical tablet dosage formulation. This method obeys Beer’s law in the concentration range of 30-90 µg/ml. with correlation coefficient of 0.9993 and exhibiting maximum absorption at 276 nm with apparent molar absorptivity of 0.1703 × 104 L mole-1 cm-1. The method is accurate and precise and is extended to pharmaceutical tablet dosage forms and there was no ...

  14. Chiral magnetic effect search in p+Au, d+Au and Au+Au collisions at RHIC

    Science.gov (United States)

    Zhao, Jie; STAR Collaboration

    2017-09-01

    The chiral magnetic effect (CME) is a fundamental property of QCD. A major background source for CME measurements is the intrinsic particle correlations (such as resonances/jets decay) coupled with the azimuthal elliptical anisotropy v2. In heavy-ion collisions, the magnetic field direction and event plane azimuthal angle Ψ2 are correlated, thus the CME and the v2-induced background are entangled. In small system p+Au and d+Au collisions, the Ψ2 is mostly due to geometry fluctuations, and thus magnetic field direction and Ψ2 are uncorrelated. The correlation measurements in small system collisions with respect to Ψ2 are only sensitive to v2-induced background while any CME is averaged to zero. In this talk, we will present the STAR measurements of two-particle correlations with respect to Ψ2 in p+Au, d+Au and Au+Au collisions at √{sNN} = 200 GeV. These results are analyzed as a function of particle multiplicity to shed light on the background contaminations of the CME measurements in heavy-ion collisions. We will also report results from a new analysis approach as a function of the particle pair invariant mass in order to suppress non-CME related physics backgrounds.

  15. Élaboration d'un guide de santé des forêts relatif à la décision du ...

    African Journals Online (AJOL)

    SARAH

    29 déc. 2014 ... de Sevilla. Bol. San. Veg. Plagas., 20: 643-651. Sousa E., Debouzie D et Pereira H., 1995. Le rôle de l'insecte Platypus cylindrus F. (Coleoptera,. Platypodidae) dans le processus de dépérissement des peuplements de chêne liège au Portugal. IOBC/wprs Bull., 18: 24-37. Sousa, E. et Inácio M.L., 2005.

  16. Microbial quality of some herbal solid dosage forms

    African Journals Online (AJOL)

    STORAGESEVER

    2010-03-15

    Mar 15, 2010 ... highly active pharmacological compounds. ... The type of dosage form, packaging, manufacturing and expiration dates of subject solid herbal .... food poisoning. Previously, the only known sources of infection were plants contact with contaminated water. (Goyal et al., 1977; Kudva et al., 1998; Solomon et al.

  17. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

    NARCIS (Netherlands)

    Jantratid, E; Prakongpan, S; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Barends, D M

    2006-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned

  18. Selective laser trabeculoplasty: Does energy dosage predict response?

    Directory of Open Access Journals (Sweden)

    Larissa Habib

    2013-01-01

    Conclusions: Within the range of total energy examined, there is a positive correlation between total energy used and amount of pressure reduction achieved at up to 3 years of follow-up. This may be useful in determining the optimal energy dosage for maximum effect for patients receiving SLT.

  19. Spectrophotometric Determination of Cilostazol in Tablet Dosage Form

    African Journals Online (AJOL)

    Erah

    Purpose: To develop simple, rapid and selective spectrophotometric methods for the determination of cilostazol in tablet dosage form. Methods: Cilostazol was dissolved in 50 % methanol and its absorbance was scanned by ultraviolet. (UV) spectrophotometry. Both linear regression equation and standard absorptivity were ...

  20. Pharmaceutical development of an intravenous dosage form of diacetylmorphine hydrochloride

    NARCIS (Netherlands)

    Klous, Marjolein G.; Nuijen, Bastiaan; van den Brink, Wim; van Ree, Jan M.; Beijnen, Jos H.

    2004-01-01

    A solid dosage form for multiple use was developed for parenteral administration of diacetylmorphine in a clinical trial on co-prescription of heroin to heroin addicts. A 300-mg/mL diacetylmorphine hydrochloride solution was lyophilised as 10-mL aliquots in 30-mL glass vials, to be reconstituted to

  1. Formulation and evaluation of tablet dosage form of Hunteria ...

    African Journals Online (AJOL)

    The present study was aimed at formulating and evaluating tablet dosage form of Hunteria umbellata (HU) seed aqueous and purified extracts. HU seeds were dried, pulverized and the powder macerated in water to obtain aqueous extract, while alkaloidal extraction process was used to obtain purified extract. Extracts ...

  2. Dosage plasmatique et globulaire du magnesium dans l'exploration ...

    African Journals Online (AJOL)

    Objectives: The allergic rhinitis represents a real public health problem. The goal of this survey is to value the interest of the dosage plasmatical and globular of magnesium in the diagnosis of the allergic rhinitis. Materials and methods : Analytic and prospective survey of 80 files, on one period of 4 years and 5 months (from ...

  3. Whole-body vibration dosage alters leg blood flow

    NARCIS (Netherlands)

    Lythgo, Noel; Eser, Prisca; de Groot, Patricia; Galea, Mary

    The effect of whole-body vibration dosage on leg blood flow was investigated. Nine healthy young adult males completed a set of 14 random vibration and non-vibration exercise bouts whilst squatting on a Galileo 900 plate. Six vibration frequencies ranging from 5 to 30 Hz (5 Hz increments) were used

  4. Software for Dosage Individualization of Voriconazole for Immunocompromised Patients

    Science.gov (United States)

    VanGuilder, Michael; Donnelly, J. Peter; Blijlevens, Nicole M. A.; Brüggemann, Roger J. M.; Jelliffe, Roger W.; Neely, Michael N.

    2013-01-01

    The efficacy of voriconazole is potentially compromised by considerable pharmacokinetic variability. There are increasing insights into voriconazole concentrations that are safe and effective for treatment of invasive fungal infections. Therapeutic drug monitoring is increasingly advocated. Software to aid in the individualization of dosing would be an extremely useful clinical tool. We developed software to enable the individualization of voriconazole dosing to attain predefined serum concentration targets. The process of individualized voriconazole therapy was based on concepts of Bayesian stochastic adaptive control. Multiple-model dosage design with feedback control was used to calculate dosages that achieved desired concentration targets with maximum precision. The performance of the software program was assessed using the data from 10 recipients of an allogeneic hematopoietic stem cell transplant (HSCT) receiving intravenous (i.v.) voriconazole. The program was able to model the plasma concentrations with a high level of precision, despite the wide range of concentration trajectories and interindividual pharmacokinetic variability. The voriconazole concentrations predicted after the last dosages were largely concordant with those actually measured. Simulations provided an illustration of the way in which the software can be used to adjust dosages of patients falling outside desired concentration targets. This software appears to be an extremely useful tool to further optimize voriconazole therapy and aid in therapeutic drug monitoring. Further prospective studies are now required to define the utility of the controller in daily clinical practice. PMID:23380734

  5. 76 FR 18648 - Oral Dosage Form New Animal Drugs; Robenacoxib

    Science.gov (United States)

    2011-04-05

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Robenacoxib AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original new animal drug...

  6. 75 FR 67031 - Oral Dosage Form New Animal Drugs; Domperidone

    Science.gov (United States)

    2010-11-01

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Domperidone AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect the original approval of a new animal...

  7. 76 FR 59023 - Oral Dosage Form New Animal Drugs; Tylosin

    Science.gov (United States)

    2011-09-23

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Tylosin AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original abbreviated new animal...

  8. 77 FR 3927 - Oral Dosage Form New Animal Drugs; Deracoxib

    Science.gov (United States)

    2012-01-26

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Deracoxib AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of a supplemental new animal drug...

  9. 76 FR 40808 - Oral Dosage Form New Animal Drugs; Amprolium

    Science.gov (United States)

    2011-07-12

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Amprolium AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original abbreviated new animal...

  10. 76 FR 78149 - Oral Dosage Form New Animal Drugs; Estriol

    Science.gov (United States)

    2011-12-16

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Estriol AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original new animal drug...

  11. 77 FR 15960 - Oral Dosage Form New Animal Drugs; Pergolide

    Science.gov (United States)

    2012-03-19

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Pergolide AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original new animal drug...

  12. Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

    NARCIS (Netherlands)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisolone are reviewed. Data on its solubility, oral absorption, and permeability are not totally conclusive, but

  13. Schistosoma mansoni : Effect of Miracidial Dosage and Aestivation ...

    African Journals Online (AJOL)

    The effect of miracidial dosage and aestivation on cercarial production of Schistosoma mansoni and on the survival rate of Biomphalaria pfeifferi was studied. B. pfeifferi measuring between 7 and 8mm in diameter were grouped into four batches based on the number of miracidia they had been infected with. A number of ...

  14. Clinical evaluation of vancomycin dosage in pediatric oncology patients

    NARCIS (Netherlands)

    Sanders, Stefan J. W. J.; Bijleveld, Yuma A.; Sinkeler, Fleur; Kemper, Elles M.; Pajkrt, Dasja; van de Wetering, Marianne; van Eijkelenburg, Natasha K. A.; Mathôt, Ron A. A.

    2014-01-01

    Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d

  15. Spectrophotometric Determination of Cilostazol in Tablet Dosage Form

    African Journals Online (AJOL)

    The results of cilostazol tablet determination by linear regression equation and standard absorptivity methods indicate purity of 100.0 - 102.4 and 98.7 - 101.1 % with ... Conclusion: These validated methods may be useful for routine analysis of cilostazol as bulk drugs, in dosage forms as well as in dissolution studies in the ...

  16. Reduced dosages of atrazine and narrow rows can provide ...

    African Journals Online (AJOL)

    hope&shola

    2010-11-08

    Nov 8, 2010 ... of reduced herbicide dosages and narrow rows to achieve adequate weed control and optimise on yields in smallholder farming .... Fertilizer was applied at a rate of 250 kg N ha-1, a third of which was applied as a basal ... ANOVA. ANOVA was performed using Genstat Release 7.22 DE. Least significant ...

  17. Effect of lead acetate administered orally at different dosage levels ...

    African Journals Online (AJOL)

    The project was conducted to evaluate the effect of lead administered as lead acetate at different dosage levels via drinking water in broiler chicks. Thirty-five healthy chicks were divided into seven groups (five chicks each) and one group was kept as un-medicated control. Groups A, B, C, D, E and F were medicated with ...

  18. A system for dosage-based functional genomics in poplar

    Science.gov (United States)

    Isabelle M. Henry; Matthew S. Zinkgraf; Andrew T. Groover; Luca Comai

    2015-01-01

    Altering gene dosage through variation in gene copy number is a powerful approach to addressing questions regarding gene regulation, quantitative trait loci, and heterosis, but one that is not easily applied to sexually transmitted species. Elite poplar (Populus spp) varieties are created through interspecific hybridization, followed by...

  19. Narrative Language Intervention Intensity and Dosage: Telling the Whole Story

    Science.gov (United States)

    Hoffman, LaVae M.

    2009-01-01

    This article expands on the work of S. F. Warren, M. E. Fey, and P. J. Yoder (2007) by applying their suggested intervention-intensity parameters to narrative language intervention with school-aged children. These pharmacologically based dosage concepts are examined from two perspectives: oral narrative skills as the target of language therapy and…

  20. Règlement de sécurité contre l'incendie relatif aux établissements recevant du public dispositions générales et commentaires de la commission centrale de sécurité

    CERN Document Server

    2015-01-01

    L’ouvrage comporte : les dispositions des Codes de la construction et de l'habitation, et l'urbanisme relatives à la protection contre l'incendie ; les articles : GN, GE, CO, AM, DF, CH, GZ, EL, EC, AS, GC et MS ; les instructions techniques ; les textes relatifs aux commissions de sécurité ; les textes concernant l’accessibilité des personnes handicapées ; les textes intéressant les qualifications des personnels des services de sécurité des ERP (SSIAP) ; la jurisprudence sur les ERP avec des arrêts du Conseil d'État et des arrêts des cours administratives d'appel.

  1. Borophene synthesis on Au(111)

    Science.gov (United States)

    Guisinger, Nathan; Kiraly, Brian; Zhang, Zhuhua; Mannix, Andrew; Hersam, Mark C.; Yakobson, Boris I.

    The recent experimental discovery of borophene, the metallic 2-dimensional allotrope of boron, has sparked tremendous interest in further exploration of this unique material. The initial synthesis of borophene was accomplished on Ag substrates and serves as a quintessential example of predictive modeling to experimental realization. In this talk, we expand the phase-space of borophene synthesis to Au. Borophene synthesis was accomplished by evaporating elemental boron onto a Au(111) substrate. The synthesized borophene retains its metallic character on Au as verified with scanning tunneling spectroscopy. Most fascinating is the difference in growth dynamics on the Au(111) substrate where the reconstructed surface presents a unique energy landscape for borophene nucleation and growth. We find that the initial low-coverage growth of borophene modifies the herringbone reconstruction into a ``trigonal'' network, where the 2D boron islands are uniformly templated across the surface. Increasing coverage results in the increasing size of the templated borophene islands until they coalesce into larger sheets. The observed growth dynamics are supported by the computational modeling of boron nucleation on Au.

  2. L’apprentissage au cern

    CERN Multimedia

    2007-01-01

    pour les professions d’électronicien(ne) et de laborantin(e) en physique L’apprentissage au CERN est régi par les lois, règlements et contrats en vigueur dans le canton de Genève. En cas de réussite à l’examen de fin d’apprentissage, les apprentis obtiennent le Certificat fédéral de capacité suisse (CFC). 6 places au total sont ouvertes au recrutement pour les deux professions. L’apprentissage dure 4 ans. Minima requis pour faire acte de candidature : avoir au moins 15 ans et moins de 21 ans à la date de début de l’apprentissage ; avoir terminé la scolarité obligatoire, au minimum 9e du Cycle d’orientation genevois (3e en France) ; être ressortissant d’un pays membre du CERN (Allemagne, Autriche, Belgique, Bulgarie, Danemark, Espagne, Finlande, France, Grèce, Hongrie, Italie, Norvège, Pays-Bas, Pologne, Portugal, Royaume-Uni, République tchèque, République slovaque , Suède, Suisse) ; pour les résidents en Suisse : être ressortissant su...

  3. Dosage de l’hémoglobine glyquée dans une population de Tlemcen : Étude transversale

    OpenAIRE

    Habi, Mohammed Amine

    2016-01-01

    La compréhension de la relation entre les valeurs usuelles de l’hémoglobine glyquée (HbA1c) en fonction des paramètres liés au sujet (l’âge, le sexe, l’IMC et les complications…etc) pourrait bien être une bonne piste pour le dépistage et le suivit du diabète. Dans ce sens, nous avons recruté dix sujets non diabétiques comme témoins et quarante cinq sujets diabétiques de type 2. Les diabétiques ont fait l’objet d’un dosage de leurs taux de glycémie et d’hémoglobine glyquée ainsi...

  4. Le rapport au savoir scientifique d'enseignantes et d'enseignants du primaire

    Science.gov (United States)

    Plonczak, Irene

    Nous avons procede a l'examen de problemes relatifs a l'education aux sciences via une approche a caractere epistemologique, contrairement a l'approche plus usuelle qui aborde les difficultes des apprenants a composer avec les connaissances dites scientifiques seulement d'un point de vue cognitif. La question de recherche que nous nous sommes posee a ete la suivante: Quel est le rapport au savoir scientifique d'enseignantes et d'enseignants du primaire? Pour repondre a cette question sur le plan methodologique, nous avons envisage l'etude du rapport au savoir scientifique d'enseignantes et d'enseignants dans un contexte relie a leur savoir et a leur expertise de tous les jours. Nos modalites de cueillette de donnees ont ete le recit ecrit et l'entrevue individuelle semi-structuree. Notre recherche a pris la forme d'une etude de cas multiples conduisant a l'etude des rapports epistemique, pratique et identitaire au savoir scientifique de dix enseignantes et enseignants d'ecoles populaires de Caracas, au Venezuela. Nos analyses nous ont amenee a affirmer que les sujets ont manifeste un rapport au savoir scientifique domine par la dependance et la soumission a l'egard des sciences ainsi que d'autres caracteristiques propres a une approche empirico-realiste. Cependant, dans un contexte relie a leur savoir-faire et a leur expertise, nous avons repere des traces de l'emergence d'une vision des sciences qui tient compte, entre autres, du caractere social de la production de ces dernieres, ce qui pourrait se qualifier comme faisant partie d'une tendance epistemologique du type socioconstructiviste. En plus, nos analyses nous amenent a suggerer que dans ce contexte les sujets auraient egalement initie une articulation entre leur savoir-faire et le savoir scientifique, ce qui les aurait amenes a vehiculer un rapport plus emancipatoire vis-a-vis les sciences. Cette articulation des savoirs permet egalement d'envisager des experiences educatives plus creatives, plus

  5. Transverse Velocity Scaling in Au+Au Fragmentation

    OpenAIRE

    Lukasik, J.; Hudan, S.; Lavaud, F.; Turzo, K.; Auger, G.; Bacri, Ch.O.; Begemann-Blaich, M.L.; Bellaize, N.; Bittiger, R.; Bocage, F.; Borderie, B.; Buchet, P.; R. Bougault(LPCC); Bouriquet, B.; Charvet, J. L.

    2002-01-01

    Invariant transverse-velocity spectra of intermediate-mass fragments were measured with the 4-pi multi-detector system INDRA for collisions of Au on Au at incident energies between 40 and 150 MeV per nucleon. Their scaling properties as a function of incident energy and atomic number Z are used to distinguish and characterize the emissions in (i) peripheral collisions at the projectile and target rapidities, and in (ii) central and (iii) peripheral collisions near mid-rapidity. The importance...

  6. La quête : les archives des Soeurs de la Providence dans le cadre d'une recherche en histoire sur l'enfermement asilaire des femmes au Québec

    Directory of Open Access Journals (Sweden)

    MARIE-CLAUDE THIFAULT

    2009-10-01

    Full Text Available Cette note de recherche rend compte des étapes méthodologiques, dans le cadre d'un projet de recherche sur l'histoire de l'enfermement asilaire des femmes au Québec entre 1873 et 1921, mettant en lumière l'importance cruciale de consulter les Archives Providence, archives privées de la communauté religieuse des Soeurs de la Providence, fondatrice de l'Asile Saint-Jean-de-Dieu en 1873. Leurs archives conservent de nombreux documents relatifs, entre autres, à la première école de gardes-malades au Québec spécialisée dans le traitement des maladies nerveuses et mentales qu'elles ont fondée en 1912. Un pan important au coeur de cette recherche permettant de découvrir les approches thérapeutiques dont a fait l'objet la population féminine de l'institution asilaire. Ce cas bien particulier expose indubitablement les marques encore profondes laissées par une génération d'historiens ayant souscrit à une histoire anticléricale. Un courant historiographique qui inévitablement a fragilisé les relations entre les communautés religieuses et les historiens.

  7. Multiscale Modeling of Au-Island Ripening on Au(100

    Directory of Open Access Journals (Sweden)

    Karin Kleiner

    2011-01-01

    Full Text Available We describe a multiscale modeling hierarchy for the particular case of Au-island ripening on Au(100. Starting at the microscopic scale, density functional theory was used to investigate a limited number of self-diffusion processes on perfect and imperfect Au(100 surfaces. The obtained structural and energetic information served as basis for optimizing a reactive forcefield (here ReaxFF, which afterwards was used to address the mesoscopic scale. Reactive force field simulations were performed to investigate more diffusion possibilities at a lower computational cost but with similar accuracy. Finally, we reached the macroscale by means of kinetic Monte Carlo (kMC simulations. The reaction rates for the reaction process database used in the kMC simulations were generated using the reactive force field. Using this strategy, we simulated nucleation, aggregation, and fluctuation processes for monoatomic high islands on Au(100 and modeled their equilibrium shape structures. Finally, by calculating the step line tension at different temperatures, we were able to make a direct comparison with available experimental data.

  8. Sex-linked dosage-sensitive modifiers as imprinting genes.

    Science.gov (United States)

    Sapienza, C

    1990-01-01

    It is proposed that differential genome imprinting is the result of dosage-sensitive modifier genes located on the sex chromosomes. Parallels between variegating position-effects in Drosophila, the phenotype elicited by transgenes in the mouse and data from several pediatric tumors indicate that the net result of the activity of such modifier genes is often cellular mosaicism in the expression of affected alleles. The mechanism by which inactivation of affected alleles is achieved is proposed to be through the formation of heterochromatic domains. Because the relevant sex-linked modifying loci are dosage sensitive in their activity, differential imprinting will occur even within homogeneous genetic backgrounds. The presence of allelic variants at these loci in non-inbred populations will give rise to variation in the observed expressivity and mode of inheritance of affected traits.

  9. Down syndrome and the complexity of genome dosage imbalance.

    Science.gov (United States)

    Antonarakis, Stylianos E

    2017-03-01

    Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic gain dosage imbalances, including microduplications. The functional genomic exploration of the post-sequencing years of chromosome 21, and the generation of numerous cellular and mouse models, have provided an unprecedented opportunity to decipher the molecular consequences of genome dosage imbalance. Studies of Down syndrome could provide knowledge far beyond the well-known characteristics of intellectual disability and dysmorphic features, as several other important features, including congenital heart defects, early ageing, Alzheimer disease and childhood leukaemia, are also part of the Down syndrome phenotypic spectrum. The elucidation of the molecular mechanisms that cause or modify the risk for different Down syndrome phenotypes could lead to the introduction of previously unimaginable therapeutic options.

  10. Dosage Form Data Used for Estimating Pediatric Antibiotic Use.

    Science.gov (United States)

    Matuz, Maria; Benko, Ria; Elseviers, Monique; Hajdu, Edit; Doro, Peter; Viola, Reka; Soos, Gyongyver

    2015-01-01

    We aimed to report a simple estimation method to enable quantification of pediatric antibiotic exposure in large aggregated datasets. Secondly, we aimed to quantify and benchmark Hungarian pediatric antibiotic use. First we intended to examine whether a correlation existed between dosage form data and the patient's age. Therefore, issued prescriptions were analyzed in pharmacies. As a correlation was found between the share of liquid oral antibacterial products and the rate of pediatric antibiotic prescriptions (R=0.884; pdosage form data and patients' age. Based on this association, massive pediatric antibiotic exposure was found. Due to the general availability of dosage form data and the ease of the estimation method, the reported concept can be used to quantify pediatric antibiotic use in large aggregated datasets or when age stratification is absent.

  11. Spectrophotometric determination of tadalafil in pure and dosage forms

    Directory of Open Access Journals (Sweden)

    ALI AL KAF

    2011-06-01

    Full Text Available Two simple, rapid, and extractive spectrophotometric methods were developed for the determination of tadalafil (TDF in both pure and tablet dosage form. These methods are based on the formation of ion-pair complexes between the basic nitrogen of the drug with bromocresol purple (BCP and methyl orange (MO in acidic buffer solution. The formed complexes were extracted with chloroform and measured at 410 and 425 nm using BCP and MO, respectively. Beer’s law was obeyed in the range 2.0–20 μg mL−1 with correlation coefficient (n = 6 ≥0.9996. The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job’s method. The proposed methods have been applied successfully for the analysis of TDF in pure and in its dosage forms. These developed methods were validated for accuracy and precision.

  12. Dosage compensation, the origin and the afterlife of sex chromosomes.

    Science.gov (United States)

    Larsson, Jan; Meller, Victoria H

    2006-01-01

    Over the past 100 years Drosophila has been developed into an outstanding model system for the study of evolutionary processes. A fascinating aspect of evolution is the differentiation of sex chromosomes. Organisms with highly differentiated sex chromosomes, such as the mammalian X and Y, must compensate for the imbalance in gene dosage that this creates. The need to adjust the expression of sex-linked genes is a potent force driving the rise of regulatory mechanisms that act on an entire chromosome. This review will contrast the process of dosage compensation in Drosophila with the divergent strategies adopted by other model organisms. While the machinery of sex chromosome compensation is different in each instance, all share the ability to direct chromatin modifications to an entire chromosome. This review will also explore the idea that chromosome-targeting systems are sometimes adapted for other purposes. This appears the likely source of a chromosome-wide targeting system displayed by the Drosophila fourth chromosome.

  13. RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring.

    Science.gov (United States)

    Huang, Haiyu; Zhao, Peisen; Chen, Pai-Yen; Ren, Yong; Liu, Xuewu; Ferrari, Mauro; Hu, Ye; Akinwande, Deji

    2014-01-01

    Miniaturized helix antennas are integrated with drug reservoirs to function as RFID wireless tag sensors for real-time drug dosage monitoring. The general design procedure of this type of biomedical antenna sensors is proposed based on electromagnetic theory and finite element simulation. A cost effective fabrication process is utilized to encapsulate the antenna sensor within a biocompatible package layer using PDMS material, and at the same time form a drug storage or drug delivery unit inside the sensor. The in vitro experiment on two prototypes of antenna sensor-drug reservoir assembly have shown the ability to monitor the drug dosage by tracking antenna resonant frequency shift from 2.4-2.5-GHz ISM band with realized sensitivity of 1.27 [Formula: see text] for transdermal drug delivery monitoring and 2.76-[Formula: see text] sensitivity for implanted drug delivery monitoring.

  14. Excipient variability and its impact on dosage form functionality.

    Science.gov (United States)

    Dave, Vivek S; Saoji, Suprit D; Raut, Nishikant A; Haware, Rahul V

    2015-03-01

    Pharmaceutical excipients are essential components of most modern dosage forms. Although defined as pharmacologically inert, excipients can be thought of as the true enablers of drug product performance. Unintentional variability in the properties of the excipients may be unavoidable, albeit minimizable. The variability may originate from the source, the excipient-manufacturing process, or during the manufacturing of dosage forms. Excipient variability may have a range of influences on their functionality and performance in the dosage form. A better understanding of these influences on the critical quality attributes of the final product is of prime importance. Modern analytical tools provide a significant assistance in characterizing excipient variability to achieve this understanding. The principles and concepts of Quality-by-Design, process analytical technology, and design space, provide a holistic risk-based approach toward manufacture and application of excipients in pharmaceutical formulations. The International Pharmaceutical Excipients Council (IPEC) has developed guidelines for proper selection, use, and evaluation of excipients in pharmaceutical products. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

  15. Status of dosage compensation of X chromosome in bovine genome.

    Science.gov (United States)

    Ka, Sojeong; Ahn, Hyeonju; Seo, Minseok; Kim, Heebal; Kim, Jin Nam; Lee, Hyun-Jeong

    2016-08-01

    Dosage compensation system with X chromosome upregulation and inactivation have evolved to overcome the genetic imbalance between sex chromosomes in both male and female of mammals. Although recent development of chromosome-wide technologies has allowed us to test X upregulation, discrete data processing and analysis methods draw disparate conclusions. A series of expression studies revealed status of dosage compensation in some species belonging to monotremes, marsupials, rodents and primates. However, X upregulation in the Artiodactyla order including cattle have not been studied yet. In this study, we surveyed the genome-wide transcriptional upregulation in X chromosome in cattle RNA-seq data using different gene filtration methods. Overall examination of RNA-seq data revealed that X chromosome in the pituitary gland expressed more genes than in other peripheral tissues, which was consistent with the previous results observed in human and mouse. When analyzed with globally expressed genes, a median X:A expression ratio was 0.94. The ratio of 1-to-1 ortholog genes between chicken and mammals, however, showed considerable reduction to 0.68. These results indicate that status of dosage compensation for cattle is not deviated from those found in rodents and primate, and this is consistent with the evolutionary history of cattle.

  16. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.

    Science.gov (United States)

    Petruševska, Marija; Berglez, Sandra; Krisch, Igor; Legen, Igor; Megušar, Klara; Peternel, Luka; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Mehta, Mehul; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2015-09-01

    Literature and experimental data relevant for the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levetiracetam are reviewed. Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical classification system (BCS). Levetiracetam's therapeutic use, its wide therapeutic index, and its favorable pharmacokinetic properties make levetiracetam a valid candidate for the BCS-based biowaiver approach. Further, no BE studies with levetiracetam IR formulations in which the test formulation failed to show BE with the comparator have been reported in the open literature. On the basis of the overall evidence, it appears unlikely that a BCS-based biowaiver approach for levetiracetam IR solid oral dosage forms formulated with established excipients would expose patients to undue risks. Thus, the BCS-based biowaiver approach procedure is recommended for IR solid oral dosage form containing levetiracetam, provided the excipients in the formulation are also present in products that have been approved in countries belonging to or associated with the International Committee on Harmonization and are used in their usual quantities, and provided the dissolution profiles of the test and reference product comply with the current requirements for BCS-based biowaivers. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

  17. QR encoded smart oral dosage forms by inkjet printing.

    Science.gov (United States)

    Edinger, Magnus; Bar-Shalom, Daniel; Sandler, Niklas; Rantanen, Jukka; Genina, Natalja

    2018-01-30

    The use of inkjet printing (IJP) technology enables the flexible manufacturing of personalized medicine with the doses tailored for each patient. In this study we demonstrate, for the first time, the applicability of IJP in the production of edible dosage forms in the pattern of a quick response (QR) code. This printed pattern contains the drug itself and encoded information relevant to the patient and/or healthcare professionals. IJP of the active pharmaceutical ingredient (API)-containing ink in the pattern of QR code was performed onto a newly developed porous and flexible, but mechanically stable substrate with a good absorption capacity. The printing did not affect the mechanical properties of the substrate. The actual drug content of the printed dosage forms was in accordance with the encoded drug content. The QR encoded dosage forms had a good print definition without significant edge bleeding. They were readable by a smartphone even after storage in harsh conditions. This approach of efficient data incorporation and data storage combined with the use of smart devices can lead to safer and more patient-friendly drug products in the future. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. 75 FR 1021 - Certain Other Dosage Form New Animal Drugs; Sevoflurane

    Science.gov (United States)

    2010-01-08

    ... Part 529 [Docket No. FDA-2009-N-0665] Certain Other Dosage Form New Animal Drugs; Sevoflurane AGENCY... part 529 is amended as follows: PART 529--CERTAIN OTHER DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority...

  19. 75 FR 38699 - Implantation or Injectable Dosage Form New Animal Drugs; Propofol

    Science.gov (United States)

    2010-07-06

    ... Administration 21 CFR Part 522 [Docket No. FDA-2010-N-0002] Implantation or Injectable Dosage Form New Animal... DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 522 continues to read as follows...

  20. Au36(SPh)23 nanomolecules.

    Science.gov (United States)

    Nimmala, Praneeth Reddy; Dass, Amala

    2011-06-22

    A new core size protected completely by an aromatic thiol, Au(36)(SPh)(23), is synthesized and characterized by MALDI-TOF mass spectrometry and UV-visible spectroscopy. The synthesis involving core size changes is studied by MS, and the complete ligand coverage by aromatic thiol group is shown by NMR.

  1. 21 CFR 524.1484 - Neomycin sulfate ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1484 Neomycin sulfate ophthalmic and topical dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Neomycin sulfate ophthalmic and topical dosage...

  2. 21 CFR 524.1580 - Nitrofurazone ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Nitrofurazone ophthalmic and topical dosage forms... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1580 Nitrofurazone ophthalmic and topical dosage forms. ...

  3. 21 CFR 522.1696 - Penicillin G procaine implantation and injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Penicillin G procaine implantation and injectable dosage forms. 522.1696 Section 522.1696 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... DOSAGE FORM NEW ANIMAL DRUGS § 522.1696 Penicillin G procaine implantation and injectable dosage forms. ...

  4. 21 CFR 524.1600 - Nystatin ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Nystatin ophthalmic and topical dosage forms. 524... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1600 Nystatin ophthalmic and topical dosage forms. ...

  5. 21 CFR 524.1200 - Kanamycin ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Kanamycin ophthalmic and topical dosage forms. 524... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1200 Kanamycin ophthalmic and topical dosage forms. ...

  6. 21 CFR 520.1263 - Lincomycin hydrochloride monohydrate oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1263 Lincomycin hydrochloride monohydrate oral dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Lincomycin hydrochloride monohydrate oral dosage...

  7. 21 CFR 524.660 - Dimethyl sulfoxide ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.660 Dimethyl sulfoxide ophthalmic and topical dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Dimethyl sulfoxide ophthalmic and topical dosage...

  8. 21 CFR 524.1881 - Prednisolone acetate ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1881 Prednisolone acetate ophthalmic and topical dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Prednisolone acetate ophthalmic and topical dosage...

  9. 21 CFR 524.1044 - Gentamicin sulfate ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1044 Gentamicin sulfate ophthalmic and topical dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Gentamicin sulfate ophthalmic and topical dosage...

  10. 21 CFR 524.1662 - Oxytetracycline hydrochloride ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Oxytetracycline hydrochloride ophthalmic and topical dosage forms. 524.1662 Section 524.1662 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... DOSAGE FORM NEW ANIMAL DRUGS § 524.1662 Oxytetracycline hydrochloride ophthalmic and topical dosage forms. ...

  11. 21 CFR 330.3 - Imprinting of solid oral dosage form drug products.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Imprinting of solid oral dosage form drug products... AS SAFE AND EFFECTIVE AND NOT MISBRANDED General Provisions § 330.3 Imprinting of solid oral dosage form drug products. A requirement to imprint an identification code on solid oral dosage form drug...

  12. 77 FR 20987 - Oral Dosage Form New Animal Drugs; Change of Sponsor; Lincomycin Hydrochloride Soluble Powder...

    Science.gov (United States)

    2012-04-09

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Change of... addition FDA has noticed two errors in Sec. 520.1696 Penicillin oral dosage forms. At this time, Sec. 520... to the Center for Veterinary Medicine, 21 CFR part 520 is amended as follows: PART 520--ORAL DOSAGE...

  13. 21 CFR 520.1802 - Piperazine-carbon disulfide complex oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1802 Piperazine-carbon disulfide complex oral dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Piperazine-carbon disulfide complex oral dosage...

  14. 21 CFR 524.981 - Fluocinolone acetonide ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... dosage forms. 524.981 Section 524.981 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.981 Fluocinolone acetonide ophthalmic and topical dosage forms. ...

  15. 21 CFR 522.2444 - Sodium thiopental implantation or injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Sodium thiopental implantation or injectable dosage forms. 522.2444 Section 522.2444 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... DOSAGE FORM NEW ANIMAL DRUGS § 522.2444 Sodium thiopental implantation or injectable dosage forms. ...

  16. 75 FR 54018 - Oral Dosage Form New Animal Drugs; Praziquantel and Pyrantel

    Science.gov (United States)

    2010-09-03

    ... Administration 21 CFR Part 520 [Docket No. FDA-2010-N-0002] Oral Dosage Form New Animal Drugs; Praziquantel and... part 520 is amended as follows: PART 520--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation... base (as pyrantel pamoate). * * * * * (d) * * * (1) * * * (i) Dosage. Administer a minimum dose of 2.27...

  17. 21 CFR 520.2158 - Streptomycin/dihydrostreptomycin oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Streptomycin/dihydrostreptomycin oral dosage forms... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2158 Streptomycin/dihydrostreptomycin oral dosage forms. ...

  18. 21 CFR 522.90 - Ampicillin implantation and injectible dosage forms.

    Science.gov (United States)

    2010-04-01

    ... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.90 Ampicillin implantation and injectible dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ampicillin implantation and injectible dosage...

  19. 21 CFR 524.390 - Chloramphenicol ophthalmic and topical dosage forms.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.390 Chloramphenicol ophthalmic and topical dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Chloramphenicol ophthalmic and topical dosage...

  20. 21 CFR 529.1044 - Gentamicin sulfate in certain other dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Gentamicin sulfate in certain other dosage forms... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS CERTAIN OTHER DOSAGE FORM NEW ANIMAL DRUGS § 529.1044 Gentamicin sulfate in certain other dosage forms. ...

  1. 21 CFR 520.1326 - Mebendazole and trichlorfon oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Mebendazole and trichlorfon oral dosage forms. 520... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1326 Mebendazole and trichlorfon oral dosage forms. ...

  2. Gene dosage compensation calibrates four regulatory RNAs to control Vibrio cholerae quorum sensing

    DEFF Research Database (Denmark)

    Svenningsen, Sine L; Tu, Kimberly C; Bassler, Bonnie L

    2009-01-01

    RNA-target HapR, promotes gene dosage compensation between the four qrr genes. Gene dosage compensation adjusts the total Qrr1-4 sRNA pool and provides the molecular mechanism underlying sRNA redundancy. The dosage compensation mechanism is exquisitely sensitive to small perturbations in Qrr levels. Precisely...

  3. Analysis of carprofen dosage forms and drug substance by high-performance liquid chromatography.

    Science.gov (United States)

    Ross, A J; Del Mauro, M D; Sokoloff, H K; Casey, D L

    1984-09-01

    A high-performance liquid chromatographic method for the analysis of carprofen in solid dosage forms and as the bulk drug substance was developed. The simple, accurate, reproducible, and stability-indicating method was shown to be applicable to drug substance and dosage form stability studies, as well as the quality control of carprofen dosage forms.

  4. Quatre géographes face à leurs émotions : Retour réflexif face à l'expérience de l'évènement séisme du 25 avril 2015 au Népal

    OpenAIRE

    Andre-Lamat, Véronique; Faulon, Marie; Jacquemet, Etienne; Sacareau, Isabelle

    2016-01-01

    A partir de témoignages relatifs au séisme qui a touché le Népal le 25 avril 2015, cet article s’interroge sur la façon dont quatre chercheurs ont géré cette catastrophe à travers le prisme de leurs émotions, en la vivant directement sur place ou à distance. La lecture de ces différentes expériences montre que l’emplacement des différents chercheurs interfère peu dans la nature et l’organisation des émotions, dans la mesure où celles-ci se révèlent assez similaires. Les mécanismes à l’origine...

  5. Global polarization measurement in Au+Au collisions

    Energy Technology Data Exchange (ETDEWEB)

    Abelev, B.I.; Adams, J.; Aggarwal, M.M.; Ahammed, Z.; Amonett,J.; Anderson, B.D.; Anderson, M.; Arkhipkin, D.; Averichev, G.S.; Bai,Y.; Balewski, J.; Barannikova, O.; Barnby, L.S.; Baudot, J.; Bekele, S.; Belaga, V.V.; Bellingeri-Laurikainen, A.; Bellwied, R.; Benedosso, F.; Bhardwaj, S.; Bhasin, A.; Bhati, A.K.; Bichsel, H.; Bielcik, J.; Bielcikova, J.; Bland, L.C.; Blyth, S.-L.; Bonner, B.E.; Botje, M.; Bouchet, J.; Brandin, A.V.; Bravar, A.; Bystersky, M.; Cadman, R.V.; Cai,X.Z.; Caines, H.; Calderon de la Barca Sanchez, M.; Castillo, J.; Catu,O.; Cebra, D.; Chajecki, Z.; Chaloupka, P.; Chattopadhyay, S.; Chen,H.F.; Chen, J.H.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Coffin, J.P.; Cormier, T.M.; Cosentino, M.R.; Cramer, J.G.; Crawford,H.J.; Das, D.; Das, S.; Daugherity, M.; de Moura, M.M.; Dedovich, T.G.; DePhillips, M.; Derevschikov, A.A.; Didenko, L.; Dietel, T.; Djawotho,P.; Dogra, S.M.; Dong, W.J.; Dong, X.; Draper, J.E.; Du, F.; Dunin, V.B.; Dunlop, J.C.; Dutta Mazumdar, M.R.; Eckardt, V.; Edwards, W.R.; Efimov,L.G.; Emelianov, V.; Engelage, J.; Eppley, G.; Erazmus, B.; Estienne, M.; Fachini, P.; Fatemi, R.; Fedorisin, J.; Filimonov, K.; Filip, P.; Finch,E.; Fine, V.; Fisyak, Y.; Fu, J.; Gagliardi, C.A.; Gaillard, L.; Ganti,M.S.; Ghazikhanian, V.; Ghosh, P.; Gonzalez, J.S.; Gorbunov, Y.G.; Gos,H.; Grebenyuk, O.; Grosnick, D.; Guertin, S.M.; Guimaraes, K.S.F.F.; Guo,Y.; Gupta, N.; Gutierrez, T.D.; Haag, B.; Hallman, T.J.; Hamed, A.; Harris, J.W.; He, W.; Heinz, M.; Henry, T.W.; Hepplemann, S.; Hippolyte,B.; Hirsch, A.; Hjort, E.; Hoffman, A.M.; Hoffmann, G.W.; Horner, M.J.; Huang, H.Z.; Huang, S.L.; Hughes, E.W.; Humanic, T.J.; Igo, G.; Jacobs,P.; Jacobs, W.W.; Jakl, P.; Jia, F.; Jiang, H.; Jones, P.G.; Judd, E.G.; Kabana, S.; Kang, K.; Kapitan, J.; Kaplan, M.; Keane, D.; Kechechyan, A.; Khodyrev,V.Yu.; Kim, B.C.; Kiryluk, J.; Kisiel, A.; Kislov, E.M.; Klein,S.R.; Kocoloski, A.; Koetke, D.D.; et al.

    2007-08-02

    The system created in non-central relativisticnucleus-nucleus collisions possesses large orbital angular momentum. Dueto spin-orbit coupling, particles produced in such a system could becomeglobally polarized along the direction of the system angular momentum. Wepresent the results of Lambda and anti-Lambda hyperon global polarizationmeasurements in Au+Au collisions at sqrt sNN=62.4 GeV and 200 GeVperformed with the STAR detector at RHIC. The observed globalpolarization of Lambda and anti-Lambda hyperons in the STAR acceptance isconsistent with zero within the precision of the measurements. Theobtained upper limit, lbar P Lambda, anti-Lambda rbar<= 0.02, iscompared to the theoretical values discussed recently in theliterature.

  6. d + Au hadron correlation measurements at PHENIX

    Energy Technology Data Exchange (ETDEWEB)

    Sickles, Anne M., E-mail: anne@bnl.gov

    2014-06-15

    In these proceedings, we discuss recent results from d + Au collisions in PHENIX ridge related measurements and their possible hydrodynamic origin. We present the v{sub 2} at midrapidity and measurements of the pseudorapidity dependence of the ridge, distinguishing between the d-going and Au-going directions. We investigate the possible geometrical origin by comparing v{sub 2} in d + Au to that in p + Pb, Au + Au and Pb + Pb collisions. Future plans to clarify the role of geometry in small collision systems at RHIC are discussed.

  7. Mechanisms and evolutionary patterns of mammalian and avian dosage compensation.

    Directory of Open Access Journals (Sweden)

    Philippe Julien

    Full Text Available As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexpression in females then drove the evolution of X inactivation (XCI. However, this model has never been directly tested and patterns and mechanisms of dosage compensation across different mammals and birds generally remain little understood. Here we trace the evolution of dosage compensation using extensive transcriptome data from males and females representing all major mammalian lineages and birds. Our analyses suggest that the X has become globally upregulated in marsupials, whereas we do not detect a global upregulation of this chromosome in placental mammals. However, we find that a subset of autosomal genes interacting with X-linked genes have become downregulated in placentals upon the emergence of sex chromosomes. Thus, different driving forces may underlie the evolution of XCI and the highly efficient equilibration of X expression levels between the sexes observed for both of these lineages. In the egg-laying monotremes and birds, which have partially homologous sex chromosome systems, partial upregulation of the X (Z in birds evolved but is largely restricted to the heterogametic sex, which provides an explanation for the partially sex-biased X (Z expression and lack of global inactivation mechanisms in these lineages. Our findings suggest that dosage reductions imposed by sex chromosome differentiation events in amniotes were resolved in strikingly different ways.

  8. Gene expression dosage regulation in an allopolyploid fish.

    Directory of Open Access Journals (Sweden)

    I Matos

    Full Text Available How allopolyploids are able not only to cope but profit from their condition is a question that remains elusive, but is of great importance within the context of successful allopolyploid evolution. One outstanding example of successful allopolyploidy is the endemic Iberian cyprinid Squalius alburnoides. Previously, based on the evaluation of a few genes, it was reported that the transcription levels between diploid and triploid S. alburnoides were similar. If this phenomenon occurs on a full genomic scale, a wide functional ''diploidization'' could be related to the success of these polyploids. We generated RNA-seq data from whole juvenile fish and from adult livers, to perform the first comparative quantitative transcriptomic analysis between diploid and triploid individuals of a vertebrate allopolyploid. Together with an assay to estimate relative expression per cell, it was possible to infer the relative sizes of transcriptomes. This showed that diploid and triploid S. alburnoides hybrids have similar liver transcriptome sizes. This in turn made it valid to directly compare the S. alburnoides RNA-seq transcript data sets and obtain a profile of dosage responses across the S. alburnoides transcriptome. We found that 64% of transcripts in juveniles' samples and 44% in liver samples differed less than twofold between diploid and triploid hybrids (similar expression. Yet, respectively 29% and 15% of transcripts presented accurate dosage compensation (PAA/PA expression ratio of 1 instead of 1.5. Therefore, an exact functional diploidization of the triploid genome does not occur, but a significant down regulation of gene expression in triploids was observed. However, for those genes with similar expression levels between diploids and triploids, expression is not globally strictly proportional to gene dosage nor is it set to a perfect diploid level. This quantitative expression flexibility may be a strong contributor to overcome the genomic shock

  9. Comprehensive review on additives of topical dosage forms for drug delivery.

    Science.gov (United States)

    Garg, Tarun; Rath, Goutam; Goyal, Amit K

    2015-12-01

    Skin is the largest organ of the human body and plays the most important role in protecting against pathogen and foreign matter. Three important modes such as topical, regional and transdermal are widely used for delivery of various dosage forms. Among these modes, the topical dosage forms are preferred because it provides local therapeutic activity when applied to the skin or mucous membranes. Additives or pharmaceutical excipients (non-drug component of dosage form) are used as inactive ingredients in dosage form or tools for structuring dosage forms. The main use of topical dosage form additives are controling the extent of absorption, maintaining the viscosity, improving the stability as well as organoleptic property and increasing the bulk of the formulation. The overall goal of this article is to provide the clinician with information related to the topical dosage form additives and their current major applications against various diseases.

  10. Antiarrhythmics: elimination and dosage considerations in hepatic impairment.

    Science.gov (United States)

    Klotz, Ulrich

    2007-01-01

    Many drugs, including most antiarrhythmics (some of which are now of limited clinical use) are eliminated by the hepatic route. If liver function is impaired, it can be anticipated that hepatic clearance will be delayed, which can lead to more pronounced drug accumulation with multiple dosing. Consequently, the potential risks of adverse events could be increased, especially as antiarrhythmics have a narrow therapeutic index. The present review summarises the available pharmacokinetic data on the most popular antiarrhythmic drugs to identify the enzymes involved in the metabolism of the various agents and confirm whether liver disease affects their elimination. Despite long usage of some of these drugs (e.g. amiodarone, diltiazem, disopyramide, procainamide and quinidine), surprisingly few data are available in patients with liver disease, making it difficult to give recommendations for dosage adjustment. In contrast, for carvedilol, lidocaine (lignocaine), propafenone and verapamil, sufficient clinical studies have been performed. For these drugs, a marked decrease in systemic and/or oral clearance and significant prolongation of the elimination half-life have been documented, which should be counteracted by a 2- to 3-fold reduction of the dosage in patients with moderate to severe liver cirrhosis. For sotalol, disopyramide and procainamide, renal clearance contributes considerably to overall elimination, suggesting that dosage reductions are probably unnecessary in patients with liver disease as long as renal function is normal. The hepatically eliminated antiarrhythmics are metabolised mainly by different cytochrome P450 (CYP) isoenzymes (e.g. CYP3A4, CYP1A2, CYP2C9, CYP2D6) and partly also by conjugations. As the extent of impairment in clearance is in the same range for all of these agents, it could be assumed that they have a common vulnerability and that, consequently, hepatic dysfunction will affect CYP-mediated phase I pathways in a similar fashion. The

  11. On p53 revival using system oriented drug dosage design.

    Science.gov (United States)

    Haseeb, Muhammad; Azam, Shumaila; Bhatti, A I; Azam, Rizwan; Ullah, Mukhtar; Fazal, Sahar

    2017-02-21

    We propose a new paradigm in the drug design for the revival of the p53 pathway in cancer cells. It is shown that the current strategy of using small molecule based Mdm2 inhibitors is not enough to adequately revive p53 in cancerous cells, especially when it comes to the extracting pulsating behavior of p53. This fact has come to notice when a novel method for the drug dosage design is introduced using system oriented concepts. As a test case, small molecule drug Mdm2 repressor Nutlin 3a is considered. The proposed method determines the dose of Nutlin to revive p53 pathway functionality. For this purpose, PBK dynamics of Nutlin have also been integrated with p53 pathway model. The p53 pathway is the focus of researchers for the last thirty years for its pivotal role as a frontline cancer suppressant protein due to its effect on cell cycle checkpoints and cell apoptosis in response to a DNA strand break. That is the reason for finding p53 being absent in more than 50% of tumor cancers. Various drugs have been proposed to revive p53 in cancer cells. Small molecule based drugs are at the foremost and are the subject of advanced clinical trials. The dosage design of these drugs is an important issue. We use control systems concepts to develop the drug dosage so that the cancer cells can be treated in appropriate time. We investigate by using a computational model how p53 protein responds to drug Nutlin 3a, an agent that interferes with the MDM2-mediated p53 regulation. The proposed integrated model describes in some detail the regulation network of p53 including the negative feedback loop mediated by MDM2 and the positive feedback loop mediated by Mdm2 mRNA as well as the reversible represses of MDM2 caused by Nutlin. The reported PBK dynamics of Nutlin 3a are also incorporated to see the full effect. It has been reported that p53 response to stresses in two ways. Either it has a sustained (constant) p53 response, or there are oscillations in p53 concentration. The

  12. Comparative dissolution testing of paracetamol commercial tablet dosage forms.

    Science.gov (United States)

    Ozkan, Y; Ozalp, Y; Savaşer, A; Ozkan, S A

    2000-01-01

    Dissolution can best be described as a tool that can provide valuable information about the availability of a drug product. In this study, nine different paracetamol tablet dosage forms available on the Turkish Drug Market have been investigated and physical controls were realized. Paddle and rotating basket apparatus methods were applied to all the formulations. In order to evaluate the dissolution rates, five different kinetics have been studied and the best fitting kinetics was found to be the Hixson-Crowell kinetics. It was found that all the preparations are in accordance with the Pharmacopeia standards.

  13. Decay spectroscopy of $^{178}$Au

    CERN Document Server

    Whitmore, B

    In this thesis, the neutron-deficient nucleus $^{178}$Au is investigated through decay spectroscopy. Si and HPGe detectors were used to analyse the decay radiation of $^{178}$Au and its daughter nuclei. Previous studies have been unable to distinguish decay radiation from different isomeric states of this nucleus. This thesis represents the first time such isomeric discrimination has been achieved, and presents tentative spin assignments of both the ground state and an isomer. The neutron-deficient gold isotopes are an area of interest for the study of shape coexistence. This is the phenomenon exhibited by nuclei able to exist at a number of close lying energy minima, each reflecting a distinct type of deformation. It is hoped that studies such as this can help identify the evolution of nuclear deformation in this region of the nuclear chart.

  14. Le CRDI au Costa Rica

    International Development Research Centre (IDRC) Digital Library (Canada)

    La stabilité politique du Costa Rica a fait de ce pays un partenaire essen- tiel du CRDI en Amérique centrale pour la recherche portant sur l'agriculture, les politiques économiques, la démocratisation et la prévention des catastrophes naturelles. Le CRDI a beaucoup contribué à la recherche en agriculture au Costa Rica,.

  15. Cas de Cotonou au Benin

    African Journals Online (AJOL)

    Au nombre de ces nuisances, figurent entre autres, la perte de temps et par ricochet d'importantes recettes .... La méthodologie utilisée est basée sur deux types d'approches : l'approche théorique et celle empirique. Le premier volet de ...... Université de Bordeaux Talence, 456 pages. SEGBEDJI, E. (2001) : Impact du trafic ...

  16. L’apprentissage au CERN

    CERN Multimedia

    Staff Association

    2016-01-01

    En 1961, sur la base du constat que l’évolution du marché du travail nécessitait un besoin croissant de personnel qualifié, le 1er accord entre la République et canton de Genève et le CERN fut signé. Cet accord avait notamment pour objet la formation professionnelle de jeunes électroniciens et techniciens de laboratoires en physique. Le CERN, acteur local économique d’importance, soulignait par cet accord sa volonté de participer au développement économique et social local. Le 1er apprenti arriva au CERN en 1965. En 1971, le centre d’apprentissage fut créé ; il accueille aujourd’hui plus d’une vingtaine d’apprentis au total, à raison d’environ six nouveaux apprentis chaque année. Cet apprentissage est dédié aux jeunes âgés e...

  17. Comportement au dégel des sols silteux Thaw Behavior in Silty Soils

    Directory of Open Access Journals (Sweden)

    Montarges R.

    2006-11-01

    Full Text Available Les problèmes géotechniques relatifs à l'offshore arctique concernent essentiellement le tassement et la dégradation mécanique des sols au dégel. Dans la perspective d'évaluation de l'importance de ces problèmes l'IFP, avec le concours du Laboratoire de Glaciologie et Géophysique de l'environnement, a entrepris en 1986-87, une étude méthodologique des sols au dégel. Deux sols silteux (un silt sableux et un silt argileux, de comportement au gel très différent, ont été utilisés pour cette étude préliminaire. L'interprétation des résultats obtenus, dans les domaines de la structure des sols gelés et de l'évolution de leurs caractéristiques mécaniques (tassement et résistance au cisaillement, montre l'influence prédominante de la présence des minéraux argileux. Les résultats de cette étude préliminaire sont brièvement examinés en terme d'application aux problèmes d'exploitation pétrolière en zones arctiques. La poursuite de l'expérimentation apparaît nécessaire notamment pour évaluer correctement l'incidence du comportement au dégel des sols sur la subsidence associée aux risques d'instabilité des conduites rigides ou flexibles. Geotechnical problems related to offshore arctic activities mainly concern the settling and mechanical degradation of soils as the result of thawing. In the outlook for assessing the importance of such problems, IFP, with the assistance of the Laboratoire de Glaciologie et Géophysique de l'Environnement, began methodological research in 1986-1987 on the effect of thawing on soils. Two silty soils (one sandy silt and one clayey silt having very different thaw behaviors were used for this preliminary study. The interpretation of the results obtained in the fields of frozen soil structure and the evolution of their mechanical properties (settling and shear strength shows the predominant influence of the presence of clayey minerals. The results of this preliminary study are examined

  18. Fabricating a Homogeneously Alloyed AuAg Shell on Au Nanorods to Achieve Strong, Stable, and Tunable Surface Plasmon Resonances

    KAUST Repository

    Huang, Jianfeng

    2015-08-13

    Colloidal metal nanocrystals with strong, stable, and tunable localized surface plasmon resonances (SPRs) can be useful in a corrosive environment for many applications including field-enhanced spectroscopies, plasmon-mediated catalysis, etc. Here, a new synthetic strategy is reported that enables the epitaxial growth of a homogeneously alloyed AuAg shell on Au nanorod seeds, circumventing the phase segregation of Au and Ag encountered in conventional synthesis. The resulting core–shell structured bimetallic nanorods (AuNR@AuAg) have well-mixed Au and Ag atoms in their shell without discernible domains. This degree of mixing allows AuNR@AuAg to combine the high stability of Au with the superior plasmonic activity of Ag, thus outperforming seemingly similar nanostructures with monometallic shells (e.g., Ag-coated Au NRs (AuNR@Ag) and Au-coated Au NRs (AuNR@Au)). AuNR@AuAg is comparable to AuNR@Ag in plasmonic activity, but that it is markedly more stable toward oxidative treatment. Specifically, AuNR@AuAg and AuNR@Ag exhibit similarly strong signals in surface-enhanced Raman spectroscopy that are some 30-fold higher than that of AuNR@Au. When incubated with a H2O2 solution (0.5 m), the plasmonic activity of AuNR@Ag immediately and severely decayed, whereas AuNR@AuAg retained its activity intact. Moreover, the longitudinal SPR frequency of AuNR@AuAg can be tuned throughout the red wavelengths (≈620–690 nm) by controlling the thickness of the AuAg alloy shell. The synthetic strategy is versatile to fabricate AuAg alloyed shells on different shaped Au, with prospects for new possibilities in the synthesis and application of plasmonic nanocrystals.

  19. Preparation and evaluation of a novel dosage form for onychomycosis.

    Science.gov (United States)

    Laffleur, Flavia; Ataii, Martin

    2017-02-25

    Onychomycosis is a common infection of the nail caused by dermatophyte affecting mostly toenails in adults being associated with limited treatment options. In this study novel dosage forms were prepared and evaluated for their suitability in treatment of onychomycosis. Films were prepared comprising polymeric excipients such as chitosan, (hydroxypropyl)methyl cellulose, hydroxyethyl-cellulose, carboxymethylcellulose according to solvent evaporation method. Developed formulations were evaluated in terms of physical appearance, stability and adhesiveness. Furthermore skin and nail irritation studies were conducted. Five potential formulations (F1-F5) were designed while F1 and F4 exhibited the most promising results in terms of stability with 26min and 40.67min, respectively, and suitability in nail application. F1 as the most favorable dosage form revealed with 2.9438kg/m/s in terms of adhesive force the most adhesive properties in contrast to the other preparations. All formulations were found to be non-skin irritating and safe to use. Taken together, these findings suggest novel designed films containing polymeric excipients as a fruitful platform for the treatment in onychomycosis. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Comparative multiplex dosage analysis in spinocerebellar ataxia type 2 patients.

    Science.gov (United States)

    Calì, F; Chiavetta, V; Ragalmuto, A; Vinci, M; Ruggeri, G; Schinocca, P; Romano, V

    2013-04-12

    We developed a new application of comparative multiplex dosage analysis (CMDA) for evaluation of the ataxin 2 gene. Expansions of the triplet CAG can cause spinocerebellar ataxia type 2 (SCA2), a neurodegenerative disease with an autosomal-dominant mode of inheritance. Molecular diagnosis of SCA2 is routinely based on the use of conventional PCR to detect the CAG expansion. However, PCR does not amplify an allele with an expansion of many triplets (>80), which is typically found in infantile and juvenile forms of SCA2, thus leading to false negatives. We propose the analysis of the ATXN2 gene by CMDA to complement existing methods currently used for the detection of large expansions of the CAG repeat. Using CMDA, the presence of any longer mutated allele in a heterozygous patient or fetus would be inferred due to dosage variation of the very frequent normal allele #22. CMDA can be completed in 1 day, at very low cost, and would be a useful tool for prenatal diagnosis and for diagnosis of presymptomatic forms of early-onset SCA2.

  1. Indications, usage, and dosage of the transfer factor.

    Science.gov (United States)

    Berrón-Pérez, Renato; Chávez-Sánchez, Raúl; Estrada-García, Iris; Espinosa-Padilla, Sara; Cortez-Gómez, Rudyard; Serrano-Miranda, Ernestina; Ondarza-Aguilera, Rodolfo; Pérez-Tapia, Mayra; Pineda Olvera, Benjamín; Jiménez-Martínez, María del Carmen; Portugués, Abraham; Rodríguez, Azucena; Cano, Laura; Pacheco, Pedro Urcino; Barrientos, Javier; Chacón, Rommel; Serafín, Jeannet; Mendez, Patricia; Monges, Abelardo; Cervantes, Edgar; Estrada-Parra, Sergio

    2007-01-01

    The transfer factor (TF) was described in 1955 by S. Lawrence. In 1992 Kirkpatrick characterized the specific TF at molecular level. The TF is constituted by a group of numerous molecules, of low molecular weight, from 1.0 to 6.0 kDa. The 5 kDa fraction corresponds to the TF specific to antigens. There are a number of publications about the clinical indications of the TF for diverse diseases, in particular those where the cellular immune response is compromised or in those where there is a deficient regulation of the immune response. In this article we present our clinical and basic experiences, especially regarding the indications, usage and dosage of the TF. Our group demonstrated that the TF increases the expression of IFN-gamma and RANTES, while decreases the expression of osteopontine. Using animal models we have worked with M. tuberculosis, and with a model of glioma with good therapeutic results. In the clinical setting we have worked with herpes zoster, herpes simplex type I, herpetic keratitis, atopic dermatitis, osteosarcoma, tuberculosis, asthma, post-herpetic neuritis, anergic coccidioidomycosis, leishmaniasis, toxoplasmosis, mucocutaneous candidiasis, pediatric infections produced by diverse pathogen germs, sinusitis, pharyngitis, and otits media. All of these diseases were studied through protocols which main goals were to study the therapeutic effects of the TF, and to establish in a systematic way diverse dosage schema and time for treatment to guide the prescription of the TF.

  2. ORODISPERSIBLE TABLET: A Patient Friendly Dosage Form (a Review

    Directory of Open Access Journals (Sweden)

    C. K. Rameesa

    2015-03-01

    Full Text Available Background: The most common and preferred route of drug administration is through the oral route. Orodispersible tablets are gaining importance among novel oral drug delivery system as they have improved patient compliance and have some additional advantages compared to other formulation. They are also solid unit dosage forms, which disintegrate in the mouth within a minute in the presence of saliva due to superdisintegrants in the formulation. Thus this type of drug delivery helps a proper per oral administration in pediatric and geriatric population where swallowing is a matter of trouble. Various scientists have prepared orodispersible tablets by following various methods. However, the most common method is the direct compression method. Other special methods are Freeze Drying,Tablet Molding, Sublimation, Spray Drying, Mass extrusion, Phase transition process, etc. Since these tablets dissolve directly in the mouth, so, their taste is also an important factor. Various approaches have been taken in order to mask the bitter taste of the drug. A number of scientists have explored several drugs in this field. Like all other solid dosage forms, they are also evaluated in the field of hardness, friability, wetting time, moisture uptake, disintegration test and dissolution test.

  3. Emergence of 3D Printed Dosage Forms: Opportunities and Challenges.

    Science.gov (United States)

    Alhnan, Mohamed A; Okwuosa, Tochukwu C; Sadia, Muzna; Wan, Ka-Wai; Ahmed, Waqar; Arafat, Basel

    2016-08-01

    The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such an extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

  4. Transport characteristics in Au/pentacene/Au diodes

    Science.gov (United States)

    Hayashi, Toshiaki; Naka, Akiyoshi; Hiroki, Masanobu; Yokota, Tomoyuki; Someya, Takao; Fujiwara, Akira

    2018-03-01

    We have used scanning and transmission electron microscopes (SEM and TEM) to study the structure of a pentacene thin film grown on a Au layer with and shown that it consists of randomly oriented amorphous pentacene clusters. We have also investigated the transport properties of amorphous pentacene in a metal–semiconductor–metal (MSM) diode structure and shown that the current is logarithmically proportional to the square root of the applied voltage, which indicates that transport occurs as the result of hopping between localized sites randomly distributed in space and energy.

  5. Acces au traitement anticancereux au Togo (access to treatment of ...

    African Journals Online (AJOL)

    Contexte : Au Togo, l'incidence et la mortalité des cancers ne cessent de croître en raison du diagnostic et de la prise en charge tardifs. D'autres raisons telles que l'absence d'oncologue spécialiste et la faible accessibilité aux médicaments anticancéreux sont de plus en plus évoquées. L'objectif de cette étude était de ...

  6. The Impact of Wine Style and Sugar Addition in liqueur d’expedition (dosage Solutions on Traditional Method Sparkling Wine Composition

    Directory of Open Access Journals (Sweden)

    Belinda Kemp

    2017-01-01

    Full Text Available The purpose of this study was to investigate the effect of wine style and cane sugar addition in the liqueur d’expedition (dosage solution on volatile aroma compounds (VOCs in traditional method sparkling wine. There were 24 bottles of each treatment produced. Treatments were sparkling wine zero dosage (ZD; NV sparkling wine + sugar (BS; unoaked still Chardonnay wine + sugar (UC; Pinot noir 2009 sparkling wine + sugar (PN; Niagara produced Brandy + sugar (B and Icewine (IW. The control treatment in the sensory analysis was an oaked still Chardonnay wine + sugar (OC because the zero-dosage wine was not suitable for a difference test that compared wines with sugar to one without. Standard wine chemical parameters were analysed before disgorging and after liqueur d’expedition was added and included; pH, titratable acidity (TA g/L, alcohol (v/v %, residual sugar (RS g/L, free and total SO2 and total phenolics (A.U.. Volatile aroma compounds (VOCs analysed by Headspace Solid- Phase Micro-Extraction Gas Chromatography-Mass Spectrometry (HS-SPME-GC-MS included two alcohols, and six ethyl esters. ZD wines had the highest foam height and highest dissolved oxygen level. Sugar affected VOC concentrations in all treatments at five weeks post-disgorging, but by 15 weeks after liqueur d’expedition addition, the wine with added sugar had similar VOC concentrations to the ZD wines. The type of wines used in the dosage solutions had more influence on VOC concentrations than sugar addition.

  7. Profil hormonal chez l’homme en cas d’infertilité au laboratoire de radio immunologie de l’institut des radioisotopes de Niamey

    OpenAIRE

    Moussa, D.; Soumana, A.; S.M. Amadou; I. Soli; I. Tahirou; Ali, A.

    2016-01-01

    Objectif: le but de l’étude est de déterminer les paramètres sociodémographiques et le profil hormonal de l’homme consultant pour infertilité. Malades et méthodes: Ont été inclus dans notre étude, tous les patients consultant pour infertilité datant d’au moins deux ans, avec un spermogramme anormal et dont le bilan hormonal comportait les dosages des quatre paramètres à savoir la FSH, la LH, la PRL et la Testostérone au laboratoire de radio Immuno dosages du service de médecine nucléaire. ...

  8. High-p(T) Tomography of d+Au and Au+Au at SPS, RHIC, and LHC.

    Science.gov (United States)

    Vitev, Ivan; Gyulassy, Miklos

    2002-12-16

    The interplay of nuclear effects on the p(T)>2 GeV inclusive hadron spectra in d+Au and Au+Au reactions at sqrt[s(NN)]=17, 200, and 5500 GeV is compared to leading order perturbative QCD calculations for elementary p+p (p+p) collisions. The competition between nuclear shadowing, Cronin effect, and jet energy loss due to medium-induced gluon radiation is predicted to lead to a striking energy dependence of the nuclear suppression/enhancement pattern in A+A reactions. We show that future d+Au data can be used to disentangle the initial and final state effects.

  9. Profiling hot and dense nuclear medium with high transverse momentum hadrons produced in d+Au and Au+Au collisions by the PHENIX experiment at RHIC

    Directory of Open Access Journals (Sweden)

    Sakaguchi Takao

    2014-03-01

    Full Text Available PHENIX measurements of high transverse momentum (pT identified hadrons in d+Au and Au+Au collisions are presented. The nuclear modification factors (RdA and RAA for π0 and ƞ are found to be very consistent in both collision systems, respectively. Using large amount of p + p and Au+Au datasets, the fractional momentum loss (Sloss and the path-length dependent yield of π0 in Au+Au collisions are obtained. The hadron spectra in the most central d+Au and the most peripheral Au+Au collisions are studied. The spectra shapes are found to be similar in both systems, but the yield is suppressed in the most peripheral Au+Au collisions.

  10. Au38(SPh)24: Au38 Protected with Aromatic Thiolate Ligands.

    Science.gov (United States)

    Rambukwella, Milan; Burrage, Shayna; Neubrander, Marie; Baseggio, Oscar; Aprà, Edoardo; Stener, Mauro; Fortunelli, Alessandro; Dass, Amala

    2017-04-06

    Au38(SR)24 is one of the most extensively investigated gold nanomolecules along with Au25(SR)18 and Au144(SR)60. However, so far it has only been prepared using aliphatic-like ligands, where R = -SC6H13, -SC12H25 and -SCH2CH2Ph. Au38(SCH2CH2Ph)24 when reacted with HSPh undergoes core-size conversion to Au36(SPh)24, and existing literature suggests that Au38(SPh)24 cannot be synthesized. Here, contrary to prevailing knowledge, we demonstrate that Au38(SPh)24 can be prepared if the ligand exchanged conditions are optimized, under delicate conditions, without any formation of Au36(SPh)24. Conclusive evidence is presented in the form of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), electrospray ionization mass spectra (ESI-MS) characterization, and optical spectra of Au38(SPh)24 in a solid glass form showing distinct differences from that of Au38(S-aliphatic)24. Theoretical analysis confirms experimental assignment of the optical spectrum and shows that the stability of Au38(SPh)24 is not negligible with respect to that of its aliphatic analogous, and contains a significant component of ligand-ligand attractive interactions. Thus, while Au38(SPh)24 is stable at RT, it converts to Au36(SPh)24 either on prolonged etching (longer than 2 hours) at RT or when etched at 80 °C.

  11. Genre et migration au Maroc

    OpenAIRE

    KHACHANI, Mohamed

    2011-01-01

    Euro-Mediterranean Consortium for Applied Research on International Migration (CARIM) Une des principales caractéristiques récentes de la migration marocaine est sa tendance à une féminisation soutenue. Le projet migratoire - qui était un projet d’hommes - intéresse de plus en plus les femmes marocaines au point de constituer actuellement près de la moitié de l’effectif migratoire marocain. Cette reconnaissance de l'importance des femmes dans la construction de l'espace migratoire a placé ...

  12. Genre et migration au Liban

    OpenAIRE

    JOUNI, Hassan

    2011-01-01

    Euro-Mediterranean Consortium for Applied Research on International Migration (CARIM) La femme possède un statut bien avancé au sein de la société libanaise : la Constitution libanaise proclame l’égalité entre les citoyens. Quelques lois et pratiques restent, toutefois, discriminatoires à l’égard de la femme, notamment la loi sur la nationalité et la loi sur le statut personnel. Une discrimination sociale très grave existe en ce qui concerne les femmes travaillant à domicile; elles subi...

  13. Nuclear Data Sheets for 181Au

    Science.gov (United States)

    Baglin, Coral M.

    1999-06-01

    Nuclear structure data pertaining to 181Au have been compiled and evaluated, and incorporated into the ENSDF data file. This evaluation of 181Au supersedes the previous publication (R. B. Firestone, Nuclear Data Sheets 62, 101 (1991) (literature cutoff date October 1990)), and includes literature available by 2 July 1999. The newly incorporated references are: 1999Mu05, 1999So01, 1995Au04, 1995Bi01, 1991Ry01, 1979Ha10, 1970Ha18.

  14. Nuclear data sheets for 181Au

    Energy Technology Data Exchange (ETDEWEB)

    Baglin, Coral M.

    1999-07-02

    Nuclear structure data pertaining to 181Au have been compiled and evaluated, and incorporated into the ENSDF data file. This evaluation of 181Au supersedes the previous publication (R. B. Firestone, Nuclear Data Sheets 62, 101 (1991) (literature cutoff date October 1990)), and includes literature available by 2 July 1999. The newly incorporated references are: 1999Mu05, 1999So01, 1995Au04, 1995Bi01, 1991Ry01, 1979Ha10, 1970Ha18.

  15. Gene expression analysis identifies global gene dosage sensitivity in cancer

    DEFF Research Database (Denmark)

    Fehrmann, Rudolf S. N.; Karjalainen, Juha M.; Krajewska, Malgorzata

    2015-01-01

    Many cancer-associated somatic copy number alterations (SCNAs) are known. Currently, one of the challenges is to identify the molecular downstream effects of these variants. Although several SCNAs are known to change gene expression levels, it is not clear whether each individual SCNA affects gene...... expression. We reanalyzed 77,840 expression profiles and observed a limited set of 'transcriptional components' that describe well-known biology, explain the vast majority of variation in gene expression and enable us to predict the biological function of genes. On correcting expression profiles...... for these components, we observed that the residual expression levels (in 'functional genomic mRNA' profiling) correlated strongly with copy number. DNA copy number correlated positively with expression levels for 99% of all abundantly expressed human genes, indicating global gene dosage sensitivity. By applying...

  16. Validated Extractive Spectrophotometric Estimation of Tadalafil in Tablet Dosage Form

    Directory of Open Access Journals (Sweden)

    J. Adlin Jino Nesalin

    2009-01-01

    Full Text Available Two simple spectrophotometric methods have been developed for the estimation of tadalafil in both pure and tablet dosage form. Methods A and B are based on the formation of ion-pair complexes of the drug with dyes such as bromothymol blue (BTB and bromocresol green (BCG in acidic buffer solution followed by their extraction with chloroform to form yellow colored chromogen with absorption maxima at 420 nm and 415 nm respectively. Beer’s law is valid in the concentration range of 10-50 mcg/mL for both the methods. These developed methods were validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the methods are reproducible and selective for the routine analysis of the said drug.

  17. Drug release characteristics of dosage forms: a review

    Directory of Open Access Journals (Sweden)

    Satinder Kakar

    2014-04-01

    Full Text Available Area of drug delivery is vast, and various advances have been made in the medical field. Besides the versatility in the dosage forms, various orders for the drug release are known, which includes zero order, first order, Higuchi model, Hixon Crowell model and Korsmeyer Peppas model. In vitro dissolution is recognized as an important element in the development of drug. The nature of the drug such as its shape, crystallinity, particle size and solubility reflects the kinetics of the drug. Various models are used to study the dissolution profiles of the new drug substances. Qualitative and quantitative changes in the drug alters the drug release and performance that is action of drug in the body, which is in vivo performance. Various model dependent methods and model independent methods have been taken into consideration for studying the drug release kinetics.

  18. Identification of pharmaceutical impurities in formulated dosage forms.

    Science.gov (United States)

    Pan, Changkang; Liu, Frances; Motto, Michael

    2011-04-01

    Structure elucidation of pharmaceutical impurities is an important part of the drug product development process. Impurities can have unwanted pharmacological or toxicological effects that seriously impact product quality and patient safety. This review focuses on current analytical strategies for chemical and structural identification of pharmaceutical impurities. Potential sources and mechanisms of impurity formation are discussed for both drug substance and drug product applications. The utility of liquid chromatography-mass spectrometry (LC/MS) for providing structure-rich information is highlighted throughout this review. Other hyphenated analytical techniques including LC/nuclear magnetic resonance, gas chromatography/MS, and size-exclusion chromatography/chemiluminescent nitrogen detectors are also discussed, as LC/MS alone sometimes cannot reveal or confirm the final structures as required during dosage form development. Copyright © 2010 Wiley-Liss, Inc.

  19. Drug dosage in continuous venoveno hemofiltration in critically ill children.

    Science.gov (United States)

    Assadi, Farahnak; Shahrbaf, Fatemeh Ghane

    2016-01-01

    The dosage of drugs in patients requiring continuous renal replacement therapy need to be adjusted based on a number of variables that that affect pharmacokinetics (PK) including patient weight, CRRT modality (convention, vs. diffusion), blood and/or effluent flow, hemofilter characteristics, physiochemical drug properties, volume of distribution, protein binding and half-life as well as residual renal function. There is a paucity of data on PK studies in children with acute kidney injury requiring CRRT. When possible, therapeutic drug monitoring should be utilized for those medications where serum drug concentrations can be obtained in a clinically relevant time frame. Also, a patient-centered team approach that includes an intensive care unit pharmacist is recommended to prevent medication-related errors and enhance safe and effective medication use is highly recommended. The aim of this article is to review the current guidelines for drug dosing in critically ill children who require continuous venovenous hemofiltration.

  20. SILYMARIN FOOD SUPPLEMENTS – ORAL SOLID DOSAGE FORMS

    Directory of Open Access Journals (Sweden)

    FELICIA G. GLIGOR

    2016-12-01

    Full Text Available Several tablet formulations containing silymarin were developed, in order to meet the requirements of different markets. Milk thistle - Silybum marianum (L. Gaertn – standardized extracts have proven their positive effect on liver functionality plus other health benefits. Lactose is a widely used excipient for the production of oral solid dosage forms. One important inconvenient of lactose is related to the lactose intolerant potential customers. Cellulose, isomalt and dicalcium phosphate have been selected as alternative possible tablet binders and diluents. Laboratory and pilot batches were studied for each excipient. The pharmacotechnical properties and silybin content of the tablets were measured and recorded in accordance to the European Pharmacopoeia. All pilot batches had results in the desired range of values in order to permit large scale compacting and blistering of the tablets. Currently the formulations containing isomalt and dicalcium phosphate that made the subject of this study are being produced on industrial scale.

  1. Nanofibrous solid dosage form of living bacteria prepared by electrospinning

    Directory of Open Access Journals (Sweden)

    I. Wagner

    2014-05-01

    Full Text Available The aim of this work was to investigate the suitability of electrospinning for biodrug delivery and to develop an electrospinning-based method to produce vaginal drug delivery systems. Lactobacillus acidophilus bacteria were encapsulated into nanofibers of three different polymers (polyvinyl alcohol and polyvinylpyrrolidone with two different molar masses. Shelf life of the bacteria could be enhanced by the exclusion of water and by preparing a solid dosage form, which is an advantageous and patient-friendly way of administration. The formulations were stored at –20, 7 and 25°C, respectively. Viability testing showed that the nanofibers can provide long term stability for huge amounts of living bacteria if they are kept at (or below 7°C. Furthermore, all kinds of nanowebs prepared in this work dissolved instantly when they got in contact with water, thus the developed biohybrid nanowebs can provide new potential ways for curing bacterial vaginosis.

  2. Predicted Habitat Suitability for Montipora Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Montipora in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  3. Predicted Habitat Suitability for Porites in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Porites in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  4. Predicted Habitat Suitability for Porites Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Porites in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  5. Predicted Habitat Suitability for Leptoseris Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Leptoseris in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  6. Predicted Habitat Suitability for All Mesophotic Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for all mesophotic corals in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to...

  7. Predicted Habitat Suitability for Leptoseris in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Leptoseris in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  8. Predicted Habitat Suitability for All Mesophotic Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is located between the islands of Maui, Lanai, Molokai and Kahoolawe, and includes the Au'au Channel as well as parts of the Kealaikahiki, Alalakeiki...

  9. Effects of maternal psychotropic drug dosage on birth outcomes

    Directory of Open Access Journals (Sweden)

    Michielsen LA

    2013-12-01

    Full Text Available Laura A Michielsen,1 Frank MMA van der Heijden,1 Paddy KC Janssen,2 Harold JH Kuijpers11Vincent van Gogh Institute for Psychiatry, Venlo, the Netherlands; 2Department of Pharmacy, VieCuri Medical Centre, Venlo, the NetherlandsBackground: The aim of this retrospective study was to explore the relationship between psychotropic medication dosage and birth outcomes.Methods: A total of 136 women were enrolled, who had an active mental disorder, were taking medication to prevent a relapse, or had a history of postpartum depression or psychosis. Medication use was evaluated for the three trimesters and during labor. Based on the defined daily dose, medication use was classified into three groups. Primary outcome variables included the infant gestational age at birth, birth weight, and Apgar scores at one and 5 minutes.Results: Our study showed a significantly higher incidence of Apgar score ≤7 at 5 minutes in women taking psychotropic drugs as compared with the group taking no medication, respectively (16.3% versus 0.0%, P=0.01. There was no significant difference between the two groups in Apgar score at one minute or in gestational age and birth weight. The results showed no significant differences in gestational age, birth weight, or Apgar scores for a low–intermediate or high dose of a selective serotonin reuptake inhibitor and for a low or intermediate dose of an antipsychotic.Conclusion: This study does not indicate a relationship between doses of selective serotonin reuptake inhibitors and antipsychotics and adverse neonatal outcomes.Keywords: pregnancy, psychotropic medication, dosage, birth outcomes

  10. Influence of dosage and chemical restraints on feline excretory urography.

    Science.gov (United States)

    Ajadi, R A; Adetunji, A; Omoerah, V O; Okoh, J U

    2006-12-01

    Three series of trials involving 10 domestic short-haired cats were carried out to determine the influence of dosage of contrast media or type of chemical restraint on feline excretory urography. The 1st series (group A) involved 5 cats sedated with 2.0 mg/kg intramuscular (i.m) injection of 2% xylazine and receiving 800 mg/kg of 76 % meglumine diatrizoate (urografin). The 2nd series (group B) involved another 5 cats sedated with 2.0 mg/kg (i.m) injection of 2% xylazine and receiving 1200 mg/kg of 76% urografin. The 3rd series (group C) involved the repeat urography of the group B cats but sedated with 15 mg/kg (i.m) injection of 5% ketamine hydrochloride. Ventrodorsal radiographs were obtained immediately, 5, 15 and 40 minutes after the injection of 76% urografin. Scores were assigned to nephrographic opacification as described in the literature. The heart rates, respiratory rates and rectal temperatures of the cats were also determined before sedation, after sedation, immediately after the injection of 76% urografin and at 15-minute intervals over a period of 60 minutes. In this study, there were significant differences (P 0.05) in heart rates, respiratory rates and rectal temperatures between the 3 groups of cats. It was therefore concluded that increasing the dosage of urografin above 800 mg/kg in cats does not provide additional beneficial effects on the nephrograms produced. Xylazine sedation was observed to produce better nephrographic opacification, however, with delayed nephrographic fading compared to ketamine sedation.

  11. Electro-analysis of the drugs in solid dosage form at platinum and gold electrodes.

    Science.gov (United States)

    Hussein, Waqar; Bishop, Edmond; Waqar, Dilshad

    2013-09-01

    Voltammetric analysis at platinum and gold rotating disc electrode (RDE) in 0.1 mol l(-1) sulphuric acid has been applied for the determination of the active ingredient in solid dosage form. Non zero intercept in the limiting current versus concentration plot was proportionally good to excellent for the solid dosage form and is free from interference from adsorption on the electrodes. All of the dosage forms proved amenable to rapid voltammetric determination with a means standard deviation of 1.2.

  12. 75 FR 20268 - Implantation or Injectable Dosage Form New Animal Drugs; Change of Sponsor; Propofol

    Science.gov (United States)

    2010-04-19

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 522 Implantation or Injectable Dosage Form New... OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 522 continues... dosage is 5.5 to 7.0 mg per kilogram (mg/kg) (2.5 to 3.2 mg/pound (lb)); for the maintenance of general...

  13. Dosage optimization in positron emission tomography: state-of-the-art methods and future prospects

    OpenAIRE

    Karakatsanis, Nicolas A; Fokou, Eleni; Tsoumpas, Charalampos

    2015-01-01

    Positron emission tomography (PET) is widely used nowadays for tumor staging and therapy response in the clinic. However, average PET radiation exposure has increased due to higher PET utilization. This study aims to review state-of-the-art PET tracer dosage optimization methods after accounting for the effects of human body attenuation and scan protocol parameters on the counting rate. In particular, the relationship between the noise equivalent count rate (NECR) and the dosage (NECR-dosage ...

  14. Dosage de la 25 OH vitamine D: expérience du laboratoire central de biochimie clinique du Centre Hospitalier Ibn Sina

    Science.gov (United States)

    Handor, Najat; Elalami, Sanae; Bouabdellah, Mounya; Srifi, Abdelatif; Esselmani, Hicham; Benchekroun, Laila; Chabraoui, Layachi

    2014-01-01

    La connaissance de la physiologie de la vitamine D a considérablement progressé ces dernières années, la faisant passer de simple vitamine à tropisme purement phosphocalcique et osseux à celui d'hormone jouant un rôle crucial dans de nombreux mécanismes physiologiques et dont le déficit est impliqué dans plusieurs pathologies. Nous présentons, dans ce travail, l'expérience du laboratoire central de biochimie dans le dosage de la 25 OH vitamine D. Enquête descriptive exhaustive portant sur les dosages de la 25 OH vitamine D effectués chez 350 patients du Centre Hospitalier Ibn Sina (CHIS). La méthode adoptée est un dosage immunologique par chimiluminescence sur microparticules réalisés sur l'auto-analyseur ARCHITECT 8200 (ABBOTT®) pendant une période de six mois (du 01 Juin 2011 au 31 Decembre 2011). Quatre vingt et onze pourcent des patients présentent une hypovitaminose. En effet 76,6% des patients souffrent d'une insuffisance en vitamine D, 12,3% de carence vitaminique et 2,6% d'ostéomalacie. L'hypovitaminose est associée dans 92,18% des cas à une normocalcémie, dans 76,87% des cas à une Hyperparathormone, dans 92,81% à des troubles thyroïdiens et dans 97,5% à une insuffisance rénale. Par ailleurs aucune relation statistiquement significative n'est établie entre l'hypovitaminose et le diabète. A la lumière des implications des hypovitaminoses dans plusieurs pathologies ou dans leurs complications et au vu du nombre élevé de patients présentant un déficit en vitamine D, il paraît judicieux d'envisager une étude épidémiologique sur le statut en vitamine D dans la population marocaine comme outil préventif avant d'élargir le dosage de ce marqueur biologique en vue d'une éventuelle supplémentation. PMID:25374649

  15. Guide relative to the modalities of statements and to the codification of criteria relative to the significant events involving the safety, the radiation protection or the environment applicable to the base nuclear installations and to the transport of radioactive matters; Guide relatif aux modalites de declaration et a la codification des criteres relatifs aux evenements significatifs impliquant la surete, la radioprotection ou l'environnement applicable aux installations nucleaires de base et au transport de matieres radioactives

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    It is necessary to analyze the events detected on an installation in order to be sure that an already occurred event does not be repeated, by taking into account the appropriate remedial measures, to avoid a worsen situation could occur by analyzing the potential consequences of precursory events of more serious ones, to promote the correct practices to improve the safety. The present guide has for vocation to define the arrangements enforceable to nuclear operators about the statements modalities of such events when these ones concern the safety of nuclear facilities, transport of radioactive matters, radiation protection or environmental protection. In any case it can substitute to the specific obligations coming from the work code, public health code and environment code, licensing decrees about releases. (N.C.)

  16. PHENIX results on collectivity in high-multiplicity p + Au, d + Au and 3He + Au collisions

    Science.gov (United States)

    Xu, Qiao

    2016-08-01

    We present recent PHENIX results for long-range two-particle correlation functions across a large pseudorapidity(η) gap in high-multiplicity p+Au, d+Au and 3He+Au collisions. Enhanced correlations are observed for particles with small azimuthal separation. Measurements of the second order Fourier coefficients (v 2) in p/d/3He+Au collisions, and the third order Fourier coefficient (v 3) in 3He+Au collision are performed using the event plane method. Scaling of v 2 with the initial eccentricity (ɛ 2) is performed in each system to investigate the role of the initial geometry in the development of a final-state anisotropy in the particle emission. The v 2 coefficients for identified π±, K± and (anti-)proton are measured as a function of transverse kinetic energy (KET) and their magnitudes are found to scale approximately with the number of constituent quarks in the hadron.

  17. Dosage optimization in positron emission tomography: state-of-the-art methods and future prospects.

    Science.gov (United States)

    Karakatsanis, Nicolas A; Fokou, Eleni; Tsoumpas, Charalampos

    2015-01-01

    Positron emission tomography (PET) is widely used nowadays for tumor staging and therapy response in the clinic. However, average PET radiation exposure has increased due to higher PET utilization. This study aims to review state-of-the-art PET tracer dosage optimization methods after accounting for the effects of human body attenuation and scan protocol parameters on the counting rate. In particular, the relationship between the noise equivalent count rate (NECR) and the dosage (NECR-dosage curve) for a range of clinical PET systems and body attenuation sizes will be systematically studied to prospectively estimate the minimum dosage required for sufficiently high NECR. The optimization criterion can be determined either as a function of the peak of the NECR-dosage curve or as a fixed NECR score when NECR uniformity across a patient population is important. In addition, the systematic NECR assessments within a controllable environment of realistic simulations and phantom experiments can lead to a NECR-dosage response model, capable of predicting the optimal dosage for every individual PET scan. Unlike conventional guidelines suggesting considerably large dosage levels for obese patients, NECR-based optimization recommends: i) moderate dosage to achieve 90% of peak NECR for obese patients, ii) considerable dosage reduction for slimmer patients such that uniform NECR is attained across the patient population, and iii) prolongation of scans for PET/MR protocols, where longer PET acquisitions are affordable due to lengthy MR sequences, with motion compensation becoming important then. Finally, the need for continuous adaptation of dosage optimization to emerging technologies will be discussed.

  18. Comparative study of anchoring groups for molecular electronics: structure and conductance of Au-S-Au and Au-NH{sub 2}-Au junctions

    Energy Technology Data Exchange (ETDEWEB)

    Kristensen, I S; Mowbray, D J; Thygesen, K S; Jacobsen, K W [Center for Atomic-scale Materials Design (CAMD), Department of Physics, Building 307, Technical University of Denmark, DK-2800 Kongens Lyngby (Denmark)

    2008-09-17

    The electrical properties of single-molecule junctions, consisting of an organic molecule coupled to metal electrodes, are sensitive to the detailed atomic structure of the molecule-metal contact. This, in turn, is determined by the anchoring group linking the molecule to the metal. With the aim of identifying and comparing the intrinsic properties of two commonly used anchoring groups, namely thiol and amine groups, we have calculated the atomic structure and conductance traces of different Au-S-Au and Au-NH{sub 2}-Au nanojunctions using density functional theory (DFT). Whereas NH{sub 2} shows a strong structural selectivity towards atop-gold configurations, S shows large variability in its bonding geometries. As a result, the conductance of the Au-NH{sub 2}-Au junction is less sensitive to the structure of the gold contacts than the Au-S-Au junction. These findings support recent experiments which show that amine-bonded molecules exhibit more well-defined conductance properties than do thiol-bonded molecules.

  19. Travailler avec Windows 7 au CERN (FR)

    CERN Multimedia

    CERN. Geneva

    2010-01-01

    Vue d'ensemble des nouveaux concepts et des changements dans l'interface utilisateur survenus dans Windows 7 depuis les versions antérieures de Windows (XP ou Vista). La mise à disposition de Windows 7 au CERN et son intégration dans l’infrastructure de Windows au CERN seront présentées.

  20. English for au pairs the au pair's guide to learning English

    CERN Document Server

    Curtis, Lucy

    2014-01-01

    English for Au Pairs has interlinked stories about a group of au pairs new to England. Marta, an 18-year-old from Poland arrives in the UK to work as an au pair. Throughout her year-long stay she has many different experiences - some bad, some good - but with the support of her host family she finds new friends and improves her English. English for Au Pairs offers insight into the joys and difficulties of being an au pair while at the same time reinforcing English language learning through grammar explanations and exercises.

  1. Au microstructure and the functional properties of Ni/Au finishes on ceramic IC packages

    Energy Technology Data Exchange (ETDEWEB)

    Winters, E.D.; Baxter, W.K. [Coors Electronic Package Co., Chattanooga, TN (United States); Braski, D.N.; Watkins, T.R. [Oak Ridge National Lab., TN (United States)

    1995-12-31

    Ni/Au plated finishes used on thick-film metallized multilayer ceramic packages for integrated circuits must meet functional requirements such as bondability, sealability, and solderability. Their ability to do so is dependent, among other things, on the ability of the Au deposit to inhibit the grain boundary diffusion and subsequent surface oxidation of Ni. In this study, the relation between functional performance, Ni diffusionr ate, and Au microstructure was examined. Extent of Ni diffusion during heating was determined by Auger electron spectroscopy for several electrolytic and electroless Ni/Au finishing processes. Results were correlated with differences in Au microstructures determined by SEM, atomic force microscopy, and XRD.

  2. AU-EU “Strategic Partnership”

    DEFF Research Database (Denmark)

    Rodt, Annemarie Peen; Okeke, Jide

    2013-01-01

    This article appraises strategic partnership between the African Union (AU) and European Union (EU). It examines the context and nature of AU and EU security relations and explores the conditions under which partnership has a positive impact in this regard. This includes an evaluation of converge......This article appraises strategic partnership between the African Union (AU) and European Union (EU). It examines the context and nature of AU and EU security relations and explores the conditions under which partnership has a positive impact in this regard. This includes an evaluation...... of convergence between the two organizations and its effect or lack thereof on African security. The article concludes that events leading up to and initiatives following the 2007 Joint Africa–European Union Strategy have produced a degree of AU and EU convergence, which has had limited impact on the efficacy...

  3. Structure of the thiolated Au130 cluster.

    Science.gov (United States)

    Tlahuice-Flores, Alfredo; Santiago, Ulises; Bahena, Daniel; Vinogradova, Ekaterina; Conroy, Cecil V; Ahuja, Tarushee; Bach, Stephan B H; Ponce, Arturo; Wang, Gangli; José-Yacamán, Miguel; Whetten, Robert L

    2013-10-10

    The structure of the recently discovered Au130-thiolate and -dithiolate clusters is explored in a combined experiment-theory approach. Rapid electron diffraction in scanning/transmission electron microscopy (STEM) enables atomic-resolution imaging of the gold core and the comparison with density functional theory (DFT)-optimized realistic structure models. The results are consistent with a 105-atom truncated-decahedral core protected by 25 short staple motifs, incorporating disulfide bridges linking the dithiolate ligands. The optimized structure also accounts, via time-dependent DFT (TD-DFT) simulation, for the distinctive optical absorption spectrum, and rationalizes the special stability underlying the selective formation of the Au130 cluster in high yield. The structure is distinct from, yet shares some features with, each of the known Au102 and Au144/Au146 systems.

  4. Gas-phase experiments on Au(III) photochemistry.

    Science.gov (United States)

    Marcum, Jesse C; Kaufman, Sydney H; Weber, J Mathias

    2011-04-14

    Irradiation of AuCl(4)(-) and AuCl(2)(OH)(2)(-) in the gas-phase using ultraviolet light (220-415 nm) leads to their dissociation. Observed fragment ions for AuCl(4)(-) are AuCl(3)(-) and AuCl(2)(-) and for AuCl(2)(OH)(2)(-) are AuCl(2)(-) and AuClOH(-). All fragment channels correspond to photoreduction of the gold atom to either Au(II) or Au(I) depending on the number of neutral ligands lost. Fragment branching ratios of AuCl(4)(-) are observed to be highly energy dependent and can be explained by comparison of the experimental data to calculated threshold energies obtained using density functional theory. The main observed spectral features are attributed to ligand-to-metal charge transfer transitions. These results are discussed in the context of the molecular-level mechanisms of Au(III) photochemistry.

  5. Magnetic depth profiling of Fe/Au multilayer using neutron ...

    Indian Academy of Sciences (India)

    Au multilayer sample for characterizing the layer structure and magnetic moment density profile. Fe/Au multilayer shows strong spin-dependent scattering at interfaces, making it a prospective GMR material. Fe/Au multilayer with bilayer ...

  6. STUDY OF REOLOGICAL PROPERTIES OF CAPTOPRIL NASAL DOSAGE FORM

    Directory of Open Access Journals (Sweden)

    Аlmochаmаd Guмаа Аbdullах

    2013-12-01

    Full Text Available The aim of this work was to study properties of ACE inhibitor captopril semisolid dosage form which was developed on the department of technology of medication in Zaporozhye State Medical University. The complex of physico-chemical, pharmacotechnological and microbiological methods was used. As an object of study 2,5% captopril nasal dosage form on the proxanol glycerogel and the base alone were used. Study of structural-mechanical characteristics of compositions was done with the rotary viscosimeter «Reotest-2» with cylindrical arrangement. Ascertainment of the dependence of effective viscosity value from displacement rate for 2,5% captopril nasal gel and its base presented that tangent tension of captopril nasal gel and its base increases with growth of deformity rate. Viscosity of compositions falls with growth of displacement rate. Such dependence indicates presence of structure in studying systems. Constructed flowing curves indicate that flow begins not instantly but after some effort for breaking structure. In period of decreasing tension viscosity of system restores. That fact confirms plastico-viscous and thixotropic properties of 2,5% captopril nasal gel and its base. It was determined that «mechanical stability» of 2,5% captopril nasal gel is 1,39 and its base is 1,43. That fact also confirms high thixotropic properties of compositions and allows to provide complete restoration of structures after applying tension at the period of technological process of manufacturing. Insignificant difference of «mechanical stability» for 2,5% captopril nasal gel and its base presents lack of interactions between active substance and the base. Reogram of 2,5% captopril nasal gel flowing is fully situated within the reological optimum of ointment consistence limits. That fact indicates high consistent properties. Factors of dynamic flowing for gel (Кd1= 38,45%; Kd2=76,48% quantitatively confirm sufficient degree of distribution at the time of

  7. Influence of dosage and chemical restraints on feline excretory urography

    Directory of Open Access Journals (Sweden)

    R.A. Ajadi

    2006-06-01

    Full Text Available Three series of trials involving 10 domestic short-haired cats were carried out to determine the influence of dosage of contrast media or type of chemical restraint on feline excretory urography. The 1st series (group A involved 5 cats sedated with 2.0 mg/kg intramuscular (i.m injection of 2 % xylazine and receiving 800 mg/kg of 76 % meglumine diatrizoate (urografin. The 2nd series (group B involved another 5 cats sedated with 2.0 mg/kg (i.m injection of 2 % xylazine and receiving 1200 mg/kg of 76% urografin. The 3rd series (group C involved the repeat urography of the group B cats but sedated with 15 mg/kg (i.m injection of 5% ketamine hydrochloride. Ventrodorsal radiographs were obtained immediately, 5, 15 and 40 minutes after the injection of 76 % urografin. Scores were assigned to nephrographic opacification as described in the literature. The heart rates, respiratory rates and rectal temperatures of the cats were also determined before sedation, after sedation, immediately after the injection of 76 % urografin and at 15-minute intervals over a period of 60 minutes. In this study, there were significant differences (P < 0.05 in the nephrographic opacification scores between the group A and group B cats at times 0 and 40 minutes post-administration of urografin. Group A cats had good initial nephrographic opacification which faded later while the nephrographic opacification of group B cats progressively increased. Similarly, nephrographic opacification was significantly (P < 0.05 higher in the xylazine-sedated cats (groups A and B than the ketamine-sedated cats (group C. However, there were no significant differences (P > 0.05 in heart rates, respiratory rates and rectal temperatures between the 3 groups of cats. It was therefore concluded that increasing the dosage of urografin above 800 mg/kg in cats does not provide additional beneficial effects on the nephrograms produced. Xylazine sedation was observed to produce better nephrographic

  8. Biowaiver monographs for immediate release solid oral dosage forms: piroxicam.

    Science.gov (United States)

    Shohin, Igor E; Kulinich, Julia I; Ramenskaya, Galina V; Abrahamsson, Bertil; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Groot, D W; Barends, Dirk M; Dressman, Jennifer B

    2014-02-01

    Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing piroxicam in the free acid form are reviewed. Piroxicam solubility and permeability, its therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA), and corresponding dissolution data are taken into consideration. The available data suggest that according to the current biopharmaceutics classification system (BCS) and all current guidances, piroxicam would be assigned to BCS Class II. The extent of piroxicam absorption seems not to depend on manufacturing conditions or excipients, so the risk of bioinequivalence in terms of area under the curve (AUC) is very low, but the rate of absorption (i.e., BE in terms of Cmax ) can be affected by the formulation. Current in vitro dissolution methods may not always reflect differences in terms of Cmax for BCS Class II weak acids; however, minor differences in absorption rate of piroxicam would not subject the patient to unacceptable risks: as piroxicam products may be taken before or after meals, the rate of absorption cannot be considered crucial to drug action. Therefore, a biowaiver for IR piroxicam solid oral dosage form is considered feasible, provided that (a) the test product contains only excipients, which are also present in IR solid oral drug products containing piroxicam, which have been approved in ICH or associated countries, for instance, those presented in Table 3 of this paper; (b) both the test and comparator drug products dissolve 85% in 30 min or less at pH 1.2, 4.5, and 6.8; and (c) the test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8. When not all of these conditions can be fulfilled, BE of the products should be established in vivo. © 2013 Wiley Periodicals, Inc. and the

  9. N.3278 report realized for the economical Affairs Commission, of the environment and the territory on the law project relative to the sector of the energy (n.3201); N.3278 rapport fait au nom de la Commission des Affaires economiques, de l'Environnement et du Territoire sur le projet de loi relatif au secteur de l'energie (n.3201)

    Energy Technology Data Exchange (ETDEWEB)

    Lenoir, J.C

    2006-08-15

    In the framework of the natural gas and electric power market opening, this law project relative to the energy sector discusses three series of dispositions: the dispositions relative to the electric power and natural gas distribution, the dispositions relative to the Gaz de France capital and the government control, and the dispositions relative to the display contracts of electric power and natural gas. Transient dispositions are also presented. (A.L.B.)

  10. N.6 report realized for the economical Affairs Commission on the law project, adopted by the National Assembly after urgency declaration, relative to the energy sector; N.6 rapport fait au nom de la commission des Affaires economiques sur le projet de loi, adopte par l'Assemblee Nationale apres declaration d'urgence, relatif au secteur de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    Poniatowski, L

    2006-10-15

    This law project concerns the organization of the french energy sector and the definition of the public utilities. After a presentation of the juridical environment of the european energy sector, the author shows, in the framework of the world energy situation, that the evolution of the juridical aspects of Gaz de France answers a real necessity. He then presents the initial law project dispositions, the modifications of the National Assembly and the amendment of the commission. (A.L.B.)

  11. Report to the prime minister relative to the decree no 2002-560 from April 18, 2002 and approving the collective service schemes; Rapport au Premier ministre relatif au decret no. 2002-560 du 18 avril 2002 approuvant les schemas de services collectifs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The collective service schemes have been implemented by the French government in order to encourage the decentralization and a complementary development of urban and rural areas in all regions of France and in the domains of high school teaching and research, culture, health, information and communication, goods and public transportation, energy, natural and rural environments, and sports. This ambitious organization requires the joint action of the government, of the local authorities, and of the overall economical and social actors of the country. This document presents the objectives of the collective service schemes and the decree written by the prime minister for their approval. (J.S.)

  12. Order of the 22 July 2004 relative to the modalities of the management of the risk bond to radon in areas open to the public; Arrete du 22 juillet 2004 relatif aux modalites de gestion du risque lie au radon dans les lieux ouverts au public

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-08-15

    This text fixes the 17 articles concerning the attitudes and the risk management in the areas, presenting radon and open to the public. It concerns the monitoring and the procedure of radon management. (A.L.B.)

  13. 75 FR 12981 - Oral Dosage Form New Animal Drugs; Tetracycline Powder

    Science.gov (United States)

    2010-03-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs... Medicine, 21 CFR part 520 is amended as follows: PART 520--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The...

  14. 21 CFR 522.960 - Flumethasone implantation or injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... FORM NEW ANIMAL DRUGS § 522.960 Flumethasone implantation or injectable dosage forms. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Flumethasone implantation or injectable dosage forms. 522.960 Section 522.960 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND...

  15. 75 FR 63085 - Certain Other Dosage Form New Animal Drugs; Progesterone Intravaginal Inserts

    Science.gov (United States)

    2010-10-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 529 Certain Other Dosage Form New Animal Drugs... OTHER DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 529 continues to read as...

  16. 77 FR 4225 - Oral Dosage Form New Animal Drugs; Milbemycin Oxime, Lufenuron, and Praziquantel

    Science.gov (United States)

    2012-01-27

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs... to the Center for Veterinary Medicine, 21 CFR part 520 is amended as follows: PART 520--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 520 continues to read as follows...

  17. 76 FR 27888 - Implantation or Injectable Dosage Form New Animal Drugs; Gonadotropin Releasing Factor-Diphtheria...

    Science.gov (United States)

    2011-05-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 522 Implantation or Injectable Dosage Form New... DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 522 continues to read as follows...

  18. 75 FR 54492 - Ophthalmic and Topical Dosage Form New Animal Drugs; Gentamicin and Betamethasone Ophthalmic...

    Science.gov (United States)

    2010-09-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New... AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 524 continues to...

  19. 75 FR 21162 - Certain Other Dosage Form New Animal Drugs; Detomidine

    Science.gov (United States)

    2010-04-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 529 Certain Other Dosage Form New Animal Drugs...: PART 529--CERTAIN OTHER DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 529...

  20. 75 FR 1274 - Implantation or Injectable Dosage Form New Animal Drugs; Hyaluronate Sodium

    Science.gov (United States)

    2010-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 522 Implantation or Injectable Dosage Form New... amended as follows: PART 522--IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority...

  1. 75 FR 4692 - Implantation or Injectable Dosage Form New Animal Drugs; Ceftiofur Crystalline Free Acid

    Science.gov (United States)

    2010-01-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 522 Implantation or Injectable Dosage Form New...--IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 522...

  2. 75 FR 16346 - Ophthalmic and Topical Dosage Form New Animal Drugs; Orbifloxacin, Mometasone Furoate Monohydrate...

    Science.gov (United States)

    2010-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New... Veterinary Medicine, 21 CFR part 524 is amended as follows: PART 524--OPHTHALMIC AND TOPICAL DOSAGE FORM NEW...

  3. 75 FR 71016 - Intramammary Dosage Form New Animal Drugs; Cloxacillin Benzathine

    Science.gov (United States)

    2010-11-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 526 Intramammary Dosage Form New Animal Drugs... DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 526 continues to read as follows...

  4. 76 FR 78150 - Ophthalmic and Topical Dosage Form New Animal Drugs; Hydrocortisone Aceponate, Miconazole Nitrate...

    Science.gov (United States)

    2011-12-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New... AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 524 continues to...

  5. 77 FR 28252 - Oral Dosage Form New Animal Drugs; Change of Sponsor; Griseofulvin Powder; Levamisole...

    Science.gov (United States)

    2012-05-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Change of...--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 520 continues to read as...

  6. 75 FR 4692 - Ophthalmic and Topical Dosage Form New Animal Drugs; Miconazole, Polymixin B, and Prednisolone...

    Science.gov (United States)

    2010-01-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New... Veterinary Medicine, 21 CFR part 524 is amended as follows: PART 524--OPHTHALMIC AND TOPICAL DOSAGE FORM NEW...

  7. 77 FR 4227 - Implantation or Injectable Dosage Form New Animal Drugs; Gonadotropin Releasing Factor Analog...

    Science.gov (United States)

    2012-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 522 Implantation or Injectable Dosage Form New...: PART 522--IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21...

  8. 77 FR 3598 - Ophthalmic and Topical Dosage Form New Animal Drugs; Gentamicin and Betamethasone Spray

    Science.gov (United States)

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New...--OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 524 continues...

  9. 76 FR 16533 - Certain Other Dosage Form New Animal Drugs; Detomidine; Correction

    Science.gov (United States)

    2011-03-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 529 Certain Other Dosage Form New Animal Drugs... the following correcting amendment: PART 529--CERTAIN OTHER DOSAGE FORM NEW ANIMAL DRUGS 0 1. The...

  10. 76 FR 72619 - Ophthalmic and Topical Dosage Form New Animal Drugs; Eprinomectin

    Science.gov (United States)

    2011-11-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New...--OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 524 continues...

  11. 77 FR 4226 - Oral Dosage Form New Animal Drugs; Gentamicin Sulfate

    Science.gov (United States)

    2012-01-27

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs... to the Center for Veterinary Medicine, 21 CFR part 520 is amended as follows: PART 520--ORAL DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for 21 CFR part 520 continues to read as follows...

  12. Studies of phase transitions in the aripiprazole solid dosage form.

    Science.gov (United States)

    Łaszcz, Marta; Witkowska, Anna

    2016-01-05

    Studies of the phase transitions in an active substance contained in a solid dosage form are very complicated but essential, especially if an active substance is classified as a BCS Class IV drug. The purpose of this work was the development of sensitive methods for the detection of the phase transitions in the aripiprazole tablets containing initially its form III. Aripiprazole exhibits polymorphism and pseudopolymorphism. Powder diffraction, Raman spectroscopy and differential scanning calorimetry methods were developed for the detection of the polymorphic transition between forms III and I as well as the phase transition of form III into aripiprazole monohydrate in tablets. The study involved the initial 10 mg and 30 mg tablets, as well as those stored in Al/Al blisters, a triplex blister pack and HDPE bottles (with and without desiccant) under accelerated and long term conditions. The polymorphic transition was not observed in the initial and stored tablets but it was visible on the DSC curve of the Abilify(®) 10 mg reference tablets. The formation of the monohydrate was observed in the diffractograms and Raman spectra in the tablets stored under accelerated conditions. The monohydrate phase was not detected in the tablets stored in the Al/Al blisters under long term conditions. The results showed that the Al/Al blisters can be recommended as the packaging of the aripiprazole tablets containing form III. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. New oral solid dosage form for furosemide oral administration.

    Science.gov (United States)

    Perioli, Luana; D'Alba, Giuseppina; Pagano, Cinzia

    2012-04-01

    Furosemide (FURO) is a drug labeled in class IV of the Biopharmaceutics Classification System (BCS) as it is both poor soluble and poor permeable. The aim of this work was to improve FURO biopharmaceutical properties by its formulation in a new solid oral dosage form. It consists in the realization of the composite MgAl-HTlc-FURO, obtained by FURO intercalation into the inorganic matrix hydrotalcite (MgAl-HTlc), and its successive formulation in tablets intended to be swallowed whole and to disintegrate rapidly in the stomach. These formulations were prepared by direct compression of a simple powder mixture constituted by MgAl-HTlc-FURO, a super disintegrant (Explotab, PolyplasdoneXL, PolyplasdoneXL-10, PolyplasdoneINF 10 or L-HPCLH-21) and a filler. The prepared formulations were submitted to disintegration time tests, and only those displaying the lowest disintegration time in gastric medium were submitted to in vitro release studies. Drug dissolution profiles from MgAl-HTlc-FURO tablets were compared with those containing crystalline FURO alone or physically mixed to MgAl-HTlc instead of MgAl-HTlc-FURO. The results revealed that tablets containing MgAl-HTlc-FURO give the best dissolution profile and that L-HPCLH-21 is able to promote the highest drug release in gastric medium, resulting in the most suitable super disintegrant in comparison with the other tested. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin.

    Science.gov (United States)

    Goodarzi, Navid; Barazesh Morgani, Ahmadreza; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Langguth, Peter; Mehta, Mehul U; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2016-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing ribavirin are reviewed. Ribavirin is highly soluble, but its permeability characteristics are not well defined. Therefore according to the Biopharmaceutical Classification System, and taking a "worst case" approach, ribavirin should be assigned to class III. As ribavirin is transported across the brush border membrane of the human jejunum by hCNT2, it shows saturable uptake in the intestine. However, no common excipients have been shown to compete for ribavirin absorption, nor have problems with BE of immediate release ribavirin formulations containing different excipients and produced by different manufacturing methods been reported in the open literature. So the risk of bioinequivalence caused by these factors appears to be low. Ribavirin is considered a narrow therapeutic index drug, as judged by comparing the minimum effective concentration and minimum toxic concentrations in blood. Although ribavirin would not be eligible for approval via a Biopharmaceutical Classification System-based biowaiver procedure according to today's guidances due to its narrow therapeutic index, the risks of biowaiving should be weighed against the considerable risks associated with studying BE of ribavirin products in healthy subjects. Copyright © 2016 American Pharmacists Association®. All rights reserved.

  15. Voltammetric determination of coenzyme Q10 in pharmaceutical dosage forms.

    Science.gov (United States)

    Michalkiewicz, Slawomir

    2008-06-01

    A simple and rapid voltammetric method has been developed for the quantitative determination of coenzyme Q(10) (CoQ(10)) in pharmaceutical preparations. Studies with differential pulse voltammetry (DPV) were carried out using a glassy carbon electrode (GCE) in a mixed solvent containing 80 vol.% acetic acid and 20 vol.% acetonitrile. A well-defined reduction peak of CoQ(10) was obtained at -20 mV vs. Ag/AgCl. The voltammetric technique applied provides a precise determination of CoQ(10) using the multiple standard addition method. The statistical parameters and the recovery study data clearly indicate good reproducibility and accuracy of the method. The accuracy of the results assessed by recovery trials was observed to be within the range of 101.1% to 102.5%. The detection and quantification limits were found to be 0.014 mM (12 mg L(-1)) and 0.046 mM (40 mg L(-1)), respectively. An analysis of real samples containing CoQ(10) showed no interferences with common additives and excipients, such as unsaturated fatty acids and soya lecithin. The method proposed does not require any pretreatment of the pharmaceutical dosage forms. A spectrophotometric determination of CoQ(10) in real samples diluted in mixtures containing ethanol and n-hexane was also performed for comparison.

  16. Self-compacting concretes (SCC: comparison of methods of dosage

    Directory of Open Access Journals (Sweden)

    B. F. Tutikian

    Full Text Available The composition of a self-compacting concrete (SCC should be defined to fulfills a number of requirements, such as self-compactibility, strength and durability. This study aims to compare three methods of dosage for SCC with local materials, so as to determine which one is the most economical and rational, thus assisting the executor in making a decision and enabling economic and technical feasibility for its application. The methods used in the experimental program were: Nan Su et al., which was developed in 2001 [1]; Repette-Melo, which was proposed in 2005 [2]; and Tutikian & Dal Molin, which was developed in 2007 [3]. From the results obtained in the experimental program, it was observed that the method which presented the lowest cost and highest compressive strength at the ages of 7, 28 and 91 days was Tutikian & Dal Molin, while the one which reached the lowest chloride ion penetration, best compactness and highest elasticity modulus was Repette-Melo. In tests carried out in the fresh state, all tested methods yielded mixtures which comply with the self-compactibility levels required by ABNT NBR 15823:2010 [4].

  17. The Evolution of Sex Chromosomes and Dosage Compensation in Plants

    Science.gov (United States)

    Shearn, Rylan; Marais, Gabriel AB

    2017-01-01

    Plant sex chromosomes can be vastly different from those of the few historical animal model organisms from which most of our understanding of sex chromosome evolution is derived. Recently, we have seen several advancements from studies on green algae, brown algae, and land plants that are providing a broader understanding of the variable ways in which sex chromosomes can evolve in distant eukaryotic groups. Plant sex-determining genes are being identified and, as expected, are completely different from those in animals. Species with varying levels of differentiation between the X and Y have been found in plants, and these are hypothesized to be representing different stages of sex chromosome evolution. However, we are also finding that sex chromosomes can remain morphologically unchanged over extended periods of time. Where degeneration of the Y occurs, it appears to proceed similarly in plants and animals. Dosage compensation (a phenomenon that compensates for the consequent loss of expression from the Y) has now been documented in a plant system, its mechanism, however, remains unknown. Research has also begun on the role of sex chromosomes in sexual conflict resolution, and it appears that sex-biased genes evolve similarly in plants and animals, although the functions of these genes remain poorly studied. Because the difficulty in obtaining sex chromosome sequences is increasingly being overcome by methodological developments, there is great potential for further discovery within the field of plant sex chromosome evolution. PMID:28391324

  18. Effect of chlorine dosage in prechlorination on trihalomethanes and haloacetic acids during water treatment process.

    Science.gov (United States)

    Niu, Zhi-Guang; Hu, Xue-Peng; Zhang, Ying; Sun, Yuan-Yuan

    2017-02-01

    To identify the effect of chlorine dosage in prechlorination on the formation of disinfection by-products during drinking water treatment process, the relationship between chlorine dosage and concentrations of THMs and HAAs was analyzed. Furthermore, the variation about the ratio of THMs/HAAs was also analyzed. The results indicated that concentrations of THMs and HAAs would rise with the increase of chlorine dosage, and TCM was the main product of four THMs, while DCAA and TCAA were the primary products of five HAAs. Moreover, the ratio of THMs to HAAs rose with the chlorine dosage increase. Thus, chlorine dosage in prechlorination had a significant impact on THMs and HAAs and should be controlled effectively.

  19. Quality-control analytical methods: considerations in compounding peroral solid dosage forms.

    Science.gov (United States)

    Vu, Nicole

    2007-01-01

    Pharmacists who are engaged in drug compounding have specific guidelines and standards that are outlined in the United States Pharmacopeia-National Formulary. Of the many dosage forms that are available for the compounder, capsules and tablets (peroral solids) represent the most stable and convenient formulations for drug combinations. Dosage units must remain consistent, and the uniformity of dosage units should be demonstrable. Specific standards for the uniformity of dosage units are outlined in United States Pharmacopeia Chapter 905, which was developed specifically for the pharmaceutical industry. The uniformity of dosage units can be demonstrated by either of two methods, Content Uniformity or Weight Variation. Weighing and blending activities are critical in compounding. Therefore, all efforts should be expended to prevent errors in weighing and other steps that could adversely affect the final preparation.

  20. L'écriture des jardins au tournant des Lumières

    Directory of Open Access Journals (Sweden)

    Sophie Le Ménahéze-Lefay

    1999-01-01

    Full Text Available La vogue des jardins dits « à l'anglaise » s'installe en France aux environs de 1760 et s'accompagne de la publication, jusque vers 1810, de très nombreux ouvrages relatifs à cet art. Ce corpus, d'une abondance sans précédent sur ce sujet, se caractérise en outre par la très grande diversité des formes littéraires qu'il investit. Comment expliquer à la fois ce foisonnement et cette hétérogénéité ?Il semble que les jardins soient l'occasion d'une utopie littéraire : celle qui, permettant de faire voler en éclats les distinctions génériques, parviendrait à mettre au point une écriture, notamment descriptive, qui concurrencerait les arts de la vue et serait elle-même l'objet qu'elle évoque.Landscape gardens became extremely fashionable in France towards 1760, and until 1810 or so, the vogue gave rise to the publication of a very large number of books on this art. This corpus of unprecedented abundance on the subject is further characterized by the great diversity of literary forms it uses. How can one account for such profusion and variety?It would seem that gardens became an opportunity for creating a literary kind of utopia: the utopia that might allow writers to smash distinctions between literary genres into pieces and create a form of writing, notably a descriptive one that became a rival for the visual arts and was itself the very object it evoked.La moda de los jardines denominados « a la inglesa » se instala en Francia hacia 1760 y está acompañada de la publicación, hasta 1810 más o menos, de obras muy numerosas sobre el arte correspondiente. Este conjunto de textos, de una abundancia sin precedente sobre el tema, se caracteriza además por la muy grande diversidad de las formas literarias que emplea. ¿ Cómo explicar a la vez tal abundancia y tal heterogeneidad ?Parece ser que los jardines son la oportunidad para una utopía literaria : aquella que, dejando que estallen las distinciones gen

  1. Au dissolution during the anodic response of short-chain alkylthiols with polycrystalline Au electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Scott R. [Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada); Guerra, Eduard [School of Engineering, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada); Siemann, Stefan [Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada); Shepherd, Jeffrey L., E-mail: jshepherd@laurentian.ca [Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada)

    2011-10-01

    Highlights: > 3-Mercaptopropionic acid (MPA) or meso-2,3-dimercaptosuccinic acid (DMSA) mediated Au corrosion in aqueous electrolytes at anodic potentials. > Au is roughened and passivated by an insoluble Au-MPA product. > Au is leached into the aqueous electrolyte as a soluble Au-DMSA species ({approx}60 ppb, 12 h). - Abstract: The electrochemical characteristics of polycrystalline Au in LiClO{sub 4} electrolyte solutions containing 3-mercaptopropionic acid (MPA) or meso-2,3-dimercaptosuccinic acid (DMSA) were studied with linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) over a wide range of positive potentials vs. Ag/AgCl. The EIS data exhibited linear capacitive behaviour at 0.0 V with either MPA or DMSA added directly to the electrolyte suggesting the formation of an adsorbed layer of the alkylthiol on the electrode surface. Above this potential, a single well-defined impedance loop appeared for electrolyte solutions containing DMSA or MPA, an observation indicative of a charge transfer reaction that could be related to several processes including oxidative desorption, oxidation of the alkylthiol, or Au oxidation/dissolution. To test for Au dissolution, the electrode was held at 0.8 V vs. Ag/AgCl for 12 h in electrolytes containing MPA or DMSA followed by surface analysis with Atomic Force Microscopy and solution analysis with Atomic Absorption Spectroscopy. When the electrolyte contained MPA, the extended potential holding procedure resulted in significant roughening of the electrode with no detectable quantities of Au in the electrolyte. X-ray photoelectron spectroscopy (XPS) analysis of the Au surface revealed an additional species in the Au 4f{sub 7/2} spectrum indicating the presence of an insoluble electrochemically generated Au(I)-MPA species. When the electrolyte contained DMSA, the Au electrode appeared smoother, 56.6 {+-} 9.6 ppb of Au was detected in the electrolyte and the XPS analysis displayed a single species in the

  2. Au/Au@polythiophene core/shell nanospheres for heterogeneous catalysis of nitroarenes.

    Science.gov (United States)

    Shin, Hye-Seon; Huh, Seong

    2012-11-01

    Monodisperse Au/Au@polythiophene core/shell nanospheres were facilely prepared through the reduction of gold precursor, AuCl₄⁻, by 2-thiopheneacetonitrile in an aqueous solution. Concomitantly, 2-thiopheneacetonitrile polymerized during this redox process. As a result, Au nanoparticle was encapsulated by conductive polymer shell to afford novel core/shell nanospheres. Interestingly, the shell was composed of very tiny Au nanoparticles surrounded with thiophene polymers. Thus, the new material is best described as Au/Au@polythiophene core/shell nanospheres. FT-IR spectroscopy revealed that the Au nanoparticles were coordinated by the C≡N groups of the polythiophene shell. Some of the C≡N groups were partially hydrolyzed into COOH groups during the redox process because of the acidic reaction condition. The shell was conductive based on the typical ohmic behavior found in electrical measurement. The Au/Au@polythiophene core/shell nanospheres were found to be very active catalysts for the hydrogenation of various nitroarene compounds into corresponding aminoarene compounds in the presence of NaBH₄. Both hydrophilic and hydrophobic nitroarenes were efficiently hydrogenated under mild conditions.

  3. Filipino au pairs on the move

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2016-01-01

    interdependence, whilst they continuously form their trajectories in relation to opportunities and restraints posed along the way by their local and transnational social relations. The article argues that examinations of migration trajectories benefit from broadening the research out in both time and space......Most Filipina au pairs in Denmark send remittances back home, and for many, au pairing forms part of longer-term migration trajectories. This article explores how Filipina au pairs try to carve out a future for themselves abroad. It shows that they navigate within tight webs of financial...

  4. Becoming independent through au pair migration

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2015-01-01

    . This article argues that, despite this critique, au pairing does play an important formative role for young Filipinas because it opens up for experiences abroad that enable them to be recognised as independent adults in Philippine society. Rather than autonomy, however, au pairs define their independence...... in terms of their capacity to assume responsibility for others, thereby achieving a position of social respect. Based on ethnographic fieldwork in Denmark and the Philippines, this article explores how young Filipinas use the social, economic, and cultural resources they gain from their au pair stay abroad...

  5. Quels sont les liens entre l'eau et l'énergie au regard des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    approvisionnement en eau pourraient‑elles aider les collectivités pauvres des ... Ce rapport fait état des résultats du projet Eau et énergie propres – évaluation des services relatifs à l'adaptation aux changements climatiques, ...

  6. Synthesis of ultrathin face-centered-cubic Au@Pt and Au@Pd core-shell nanoplates from hexagonal-close-packed Au square sheets

    KAUST Repository

    Fan, Zhanxi

    2015-03-17

    The synthesis of ultrathin face-centered-cubic (fcc) Au@Pt rhombic nanoplates is reported through the epitaxial growth of Pt on hexagonal-close-packed (hcp) Au square sheets (AuSSs). The Pt-layer growth results in a hcp-to-fcc phase transformation of the AuSSs under ambient conditions. Interestingly, the obtained fcc Au@Pt rhombic nanoplates demonstrate a unique (101)f orientation with the same atomic arrangement extending from the Au core to the Pt shell. Importantly, this method can be extended to the epitaxial growth of Pd on hcp AuSSs, resulting in the unprecedented formation of fcc Au@Pd rhombic nanoplates with (101)f orientation. Additionally, a small amount of fcc (100)f-oriented Au@Pt and Au@Pd square nanoplates are obtained with the Au@Pt and Au@Pd rhombic nanoplates, respectively. We believe that these findings will shed new light on the synthesis of novel noble bimetallic nanostructures. Phase change: Ultrathin Au@Pt and Au@Pd core-shell nanoplates were prepared from Au square sheets. A phase transformation from hexagonal close-packed (hcp) to face-centered cubic (fcc) is observed upon coating the hcp Au square sheets with Pt or Pd under ambient conditions. The prepared fcc Au@Pt and Au@Pd rhombic nanoplates demonstrate unique (101)f orientation (picture shows a typical fcc Au@Pt rhombic nanoplate). © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Preactivated thiolated nanoparticles: A novel mucoadhesive dosage form.

    Science.gov (United States)

    Menzel, Claudia; Bonengel, Sonja; Pereira de Sousa, Irene; Laffleur, Flavia; Prüfert, Felix; Bernkop-Schnürch, Andreas

    2016-01-30

    Within this study a novel form of mucoadhesive nanoparticles (NPs) exhibiting a prolonged residence time on mucosal tissues was developed. In order to achieve this goal a new thiomer was synthesized by the covalent attachment of the amino acid l-cysteine ethyl ester to poly(acrylic acid) (100 kDa). The free thiol groups were in the following preactivated with the aromatic thiol bearing ligand 2-mercaptonicotinic acid (2-MNA) and the amount of coupled l-cysteine ethyl ester as well as the amount of attached 2-MNA was determined. Based on this, preactivated thiomer NPs were prepared by ionic gelation with polyethylenimine (PEI). The resulting NPs were characterized regarding size and zeta potential. Furthermore their mucoadhesive properties were investigated via rheological measurements with porcine intestinal mucus and via determination of the particles' mucosal residence time. Results showed that 1666.74 μmol l-cysteine ethyl ester and 603.07 μmol 2-MNA could be attached per gram polymer. NPs were in a size range of 112.67-252.84 nm exhibiting a zeta potential of -29 mV. Thiolated NPs only led to a 2-fold increase in mucus viscosity whereas preactivated NPs showed a 6-fold higher mucus viscosity than unmodified NPs. The mucosal residence time of thiolated NPs was 1.6-fold prolonged and that of preactivated NPs even 4.4-fold higher compared to unmodified particles. Accordingly, preactivated thiolated NPs providing a prolonged residence time on mucosal membranes could be a promising dosage form for various applications. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Carboxymethyl starch mucoadhesive microspheres as gastroretentive dosage form.

    Science.gov (United States)

    Lemieux, Marc; Gosselin, Patrick; Mateescu, Mircea Alexandru

    2015-12-30

    Carboxymethyl starch microspheres (CMS-MS) were produced from carboxymethyl starch powder (CMS-P) with a degree of substitution (DS) from 0.1 to 1.5 in order to investigate the influence of DS on physicochemical, drug release and mucoadhesion properties as well as interactions with gastrointestinal tract (GIT) epithelial barrier models. Placebo and furosemide loaded CMS-MS were obtained by emulsion-crosslinking with sodium trimetaphosphate (STMP). DS had an impact on increasing equilibrium water uptake and modulating drug release properties of the CMS-MS according to the surrounding pH. The transepithelial electrical resistance (TEER) of NCI-N87 gastric cell monolayers was not influenced in presence of CMS-MS, whereas that of Caco-2 intestinal cell monolayers decreased with increasing DS but recovered initial values at about 15h post-treatment. CMS-MS with increasing DS also enhanced furosemide permeability across both NCI-N87 and Caco-2 monolayers at pH gradients from 3.0 to 7.4. Mucoadhesion of CMS-MS on gastric mucosa (acidic condition) increased with the DS up to 55% for a DS of 1.0 but decreased on neutral intestinal mucosa to less than 10% with DS of 0.1. The drug release, permeability enhancement and mucoadhesive properties of the CMS-MS suggest CMS-MS with DS between 0.6 and 1.0 as suitable excipient for gastroretentive oral delivery dosage forms. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Gene dosage and suceptibility to insulin-dependent diabetes.

    Science.gov (United States)

    Spielman, R S; Baker, L; Zmijewski, C M

    1980-10-01

    1. All members of 33 families in which two or more sibs have insulin-dependent diabetes mellitus (IDDM) were HLA-typed. The results strongly support the hypothesis that, closely linked to the HLA region, there is a locus (S) for susceptibility to IDDM. We use Sd for alleles at this locus which confer susceptibility to disease, and Sa for all other alleles. 2. Published prevalence (recurrence) rates for relatives of an IDDM proband, which are essential for the analysis, are reviewed critically, and a new estimate of prevalence at age 30 in the general population is calculated from published data. 3. The analysis allows for greater risk (penetrance) of the genotype SdSd (two doses of Sd) than of SaSd (one dose of Sd) and for recombination between the HLA region and S. With either our own data on 26 affected sib pairs or a much larger sample assembled by pooling with published data, the maximum-likelihood estimate of the two-dose penetrance is 71%, of the one dose penetrance 6.5%. The hypothesis of differential penetrance according to gene dosage provides a significantly better explanation than either simple dominant or simple recessive inheritance. 4. Estimates of the recombination fraction between HLA and S are very sensitive to the proportion of affected sib pairs sharing neither HLA haplotype, which varies considerably among the samples pooled. With the pooled data the recombination fraction is estimated as 3%, but in view of the strong associations with particular HLA alleles seen in population data, this should probably be considered an upper limit.

  10. Lifestyle and vitamin D dosage in women with breast cancer.

    Science.gov (United States)

    Oliveira Sediyama, Catarina Maria; Dias, Manoela Maciel Dos Santos; Pessoa, Milene Cristine; Queiroz, Andréia Ribeiro; Suhett, Lara Gomes; Freitas, Renata Nascimento; De Paula, Sérgio Oliveira; Peluzio, Maria do Carmo Gouveia

    2016-09-20

    The prevention strategy of breast cancer is still the key factor for early diagnosis and the most effective method for tracking the disease. This study aimed to evaluate the association vitamin D level with breast cancer in women. This hospital case-control study was conducted with 181 women with breast cancer and 197 healthy controls. Vitamin D status, calcium, phosphorus and PTH serum dosage and data collection related to lifestyle and patient's history, besides anthropometric measurements were performed. Univariate analysis (Chi-square and raw odds ratio) and multivariate analysis were performed through multivariate logistic regression. This study shows a higher value of vitamin D in health controls (26.9 mg/dL) than in breast cancer women (24.8 mg/dL). Higher numbers of women with sufficient vitamin D status (34.85%) were found in control group than cancer group. Using the multiple logistic regression model, the family history of breast cancer (OR 36.37, 95%CI 4.75-278.50) and menopause (OR 5.17, 95% CI 2.72-9.80) had a direct association with breast cancer, while the level of vitamin D (OR 0.95, 95%CI 0.91-0.99) and moderate physical activity (OR 0.31, 95%CI 0.10-0.93) maintained the inverse associations with the disease. Vitamin D status and the practice of moderate physical activity were considered protective factors for breast cancer. However, menopause and family history of breast cancer were considered a risk factor for breast cancer.

  11. Mathematical modeling of drug release from lipid dosage forms.

    Science.gov (United States)

    Siepmann, J; Siepmann, F

    2011-10-10

    Lipid dosage forms provide an interesting potential for controlled drug delivery. In contrast to frequently used poly(ester) based devices for parenteral administration, they do not lead to acidification upon degradation and potential drug inactivation, especially in the case of protein drugs and other acid-labile active agents. The aim of this article is to give an overview on the current state of the art of mathematical modeling of drug release from this type of advanced drug delivery systems. Empirical and semi-empirical models are described as well as mechanistic theories, considering diffusional mass transport, potentially limited drug solubility and the leaching of other, water-soluble excipients into the surrounding bulk fluid. Various practical examples are given, including lipid microparticles, beads and implants, which can successfully be used to control the release of an incorporated drug during periods ranging from a few hours up to several years. The great benefit of mechanistic mathematical theories is the possibility to quantitatively predict the effects of different formulation parameters and device dimensions on the resulting drug release kinetics. Thus, in silico simulations can significantly speed up product optimization. This is particularly useful if long release periods (e.g., several months) are targeted, since experimental trial-and-error studies are highly time-consuming in these cases. In the future it would be highly desirable to combine mechanistic theories with the quantitative description of the drug fate in vivo, ideally including the pharmacodynamic efficacy of the treatments. Copyright © 2011 Elsevier B.V. All rights reserved.

  12. Et pourquoi pas au CERN ?

    CERN Multimedia

    Staff Association

    2015-01-01

    Télétravail ou travail à distance, aménagement des horaires de travail et autres évolutions favorables à un meilleur équilibre vie privée et vie professionnelle sont adoptés par nombre d’entreprises et d’organisations !   Rendu possible grâce au développement de nouvelles technologies dont Internet, le travail à distance séduit de plus en plus de personnels, ainsi que de plus en plus de sociétés qui y trouvent des avantages en matière de gestion de l’espace, de sécurité (moins de trajets domicile-entreprise), de développement durable (moins de pollution), de motivation et de bien-être de leurs personnels. Les horaires aménagés, voire les « core-hours1 », sont également des pratiques de plus e...

  13. Aspects descriptifs du VIH/SIDA chez les sujets âgés de 50 ans et plus suivis au Centre de Traitement Agréé de Bafoussam - Cameroun

    Science.gov (United States)

    Mbopi-Kéou, François-Xavier; Djomassi, Lucienne Dempouo; Monebenimp, Francisca

    2012-01-01

    Introduction La littérature scientifique dispose de très peu de données relatives à l’épidémiologie du VIH chez les sujets âgés en Afrique subsaharienne. Au Cameroun, les caractéristiques épidémiologiques de l'infection par le VIH chez les sujets âgés de 50 ans et plus ne sont pas documentées. Méthodes Dans une étude de cohorte rétrospective et une enquête transversale, nous avons comparé les caractéristiques clinico-biologiques et la survie post thérapeutique des patients âgés de 50 ans et plus, sous traitement antirétroviral au Centre de Traitement Agrée de Bafoussam - Cameroun, aux adultes plus jeunes. Résultats L’âge moyen était de 39 ans, les extrêmes étant 17 et 88 ans. Les sujets âgés de 50 ans et plus représentaient 14,1% des cas. Les plus âgés étaient moins bien informés sur les modes de transmission du virus (p = 0,04). Leur séropositivité au VIH était le plus souvent découverte au décours d'une infection opportuniste (p = 0,02). La fréquence de comorbidité était significativement plus élevée chez les personnes âgées de 50 ans et plus (p VIH. La promotion du dépistage et les programmes d’éducation sanitaire relatifs au VIH/SIDA devraient être renforcés au sein de cette communauté déjà affaiblie par le poids de l’âge, afin de réduire l'incidence du SIDA et de leur assurer prise en charge précoce. PMID:23133707

  14. Application of DBNPA dosage for biofouling control in spiral wound membrane systems

    KAUST Repository

    Siddiqui, Amber

    2017-05-30

    Biocides may be used to control biofouling in spiral-wound reverse osmosis (RO) and nanofiltration (NF) systems. The objective of this study was to investigate the effect of biocide 2,2-dibromo-3-ni-trilopropionamide (DBNPA) dosage on biofouling control. Preventive biofouling control was studied applying a continuous dosage of substrate (0.5 mg/L) and DBNPA (1 mg/L). Curative biofouling control was studied on pre-grown biofilms, once again applying a continuous dosage of substrate (0.5 mg acetate C/L) and DBNPA (1 and 20 mg/L). Biofouling studies were performed in membrane fouling simulators (MFSs) supplied with biodegradable substrate and DBNPA. The pressure drop was monitored in time and at the end of the study, the accumulated biomass in MFS was quantified by adenosine triphosphate (ATP) and total organic carbon (TOC) analysis. Continuous dosage of DBNPA (1 mg/L) prevented pressure drop increase and biofilm accumulation in the MFSs during a run time of 7 d, showing that biofouling can be managed by preventive DBNPA dosage. For biofouled systems, continuous dosage of DBNPA (1 and 20 mg/L) inactivated the accumulated biomass but did not restore the original pressure drop and did not remove the accumulated inactive cells and extracellular polymeric substances (EPS), indicating DBNPA dosage is not suitable for curative biofouling control.

  15. Manufacture of fibrous dosage forms by wet micro-patterning and drying.

    Science.gov (United States)

    Blaesi, Aron H; Saka, Nannaji

    2017-09-18

    Recently, we have introduced fibrous dosage forms prepared by the predictable deposition, or 3D-micro-patterning, of a drug-laden fibrous melt on a surface. Such dosage forms enable precisely controlled microstructures and drug release rates, and can be manufactured by an efficient, continuous melt process. However, the applicability of melt-processing to manufacture pharmaceutical dosage forms is limited because the temperatures at which suitable excipients plasticize by melting are greater than the degradation or melting temperatures of many kinds of drugs. In this work, therefore, a continuous wet micro-patterning process is presented for the manufacture of fibrous dosage forms, wherein the excipient is plasticized by solvation and solidified by drying. Models are developed to illustrate the effects of the fiber radius, the inter-fiber spacing, the drying conditions, and the viscosity of the drug-excipient-solvent mixture on microstructure, drug release properties, and process time of the dosage forms. Experimental results show that the microstructure can be well controlled by the above parameters. They also confirm that the drug release behaviour of the dosage forms is predictable. Furthermore, the small excipient particles and the thin fibers are solvated, micro-patterned, and dried rapidly, in a few seconds or about a minute, respectively, which affords short process times. Thus it is demonstrated that fibrous dosage forms with predictable properties can be readily prepared by a continuous wet micro-patterning process. Copyright © 2017. Published by Elsevier Inc.

  16. Teacher factors contributing to dosage of the KiVa anti-bullying program.

    Science.gov (United States)

    Swift, Lauren E; Hubbard, Julie A; Bookhout, Megan K; Grassetti, Stevie N; Smith, Marissa A; Morrow, Michael T

    2017-12-01

    The KiVa Anti-Bullying Program (KiVa) seeks to meet the growing need for anti-bullying programming through a school-based, teacher-led intervention for elementary school children. The goals of this study were to examine how intervention dosage impacts outcomes of KiVa and how teacher factors influence dosage. Participants included 74 teachers and 1409 4th- and 5th-grade students in nine elementary schools. Teachers and students completed data collection at the beginning and end of the school year, including measures of bullying and victimization, correlates of victimization (depression, anxiety, peer rejection, withdrawal, and school avoidance), intervention cognitions/emotions (anti-bullying attitudes, and empathy toward victims), bystander behaviors, and teacher factors thought to relate to dosage (self-efficacy for teaching, professional burnout, perceived principal support, expected effectiveness of KiVa, perceived feasibility of KiVa). The dosage of KiVa delivered to classrooms was measured throughout the school year. Results highlight dosage as an important predictor of change in bullying, victimization, correlates of victimization, bystander behavior, and intervention cognitions/emotions. Of the teacher factors, professional burnout uniquely predicted intervention dosage. A comprehensive structural equation model linking professional burnout to dosage and then to child-level outcomes demonstrated good fit. Implications for intervention design and implementation are discussed. Copyright © 2017 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

  17. Comparative efficiencies of photothermal destruction of malignant cells using antibody-coated silica-Au nanoshells, hollow Au/Ag nanospheres and Au nanorods

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Fong-Yu; Chen, Chen-Tai; Yeh, Chen-Sheng, E-mail: csyeh@mail.ncku.edu.t [Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan (China)

    2009-10-21

    Three Au-based nanomaterials (silica-Au nanoshells, hollow Au/Ag nanospheres and Au nanorods) were evaluated for their comparative photothermal efficiencies at killing three types of malignant cells (A549 lung cancer cells, HeLa cervix cancer cells and TCC bladder cancer cells) using a CW NIR laser. Photodestructive efficiency was evaluated as a function of the number of nanoparticles required to destroy the cancer cells under 808 nm laser wavelength at fixed laser power. Of the three nanomaterials, silica/Au nanoshells needed the minimum number of particles to produce effective photodestruction, whereas Au nanorods needed the largest number of particles. Together with the calculated photothermal conversion efficiency, the photothermal efficiency rankings are silica-Au nanoshells > hollow Au/Ag nanospheres > Au nanorods. Additionally, we found that HeLa cells seem to present better heat tolerance than the other two cancer cell lines.

  18. Initial Eccentricity in Deformed 197Au+197Au and 238U+238U Collisions at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Filip, Peter; Lednicky, Richard; Masui, Hiroshi; Xu, Nu

    2010-07-07

    Initial eccentricity and eccentricity fluctuations of the interaction volume created in relativistic collisions of deformed {sup 197}Au and {sup 238}U nuclei are studied using optical and Monte-Carlo (MC) Glauber simulations. It is found that the non-sphericity noticeably influences the average eccentricity in central collisions and eccentricity fluctuations are enhanced due to deformation. Quantitative results are obtained for Au+Au and U+U collisions at energy {radical}s{sub NN} = 200 GeV.

  19. Photovoltage responses of graphene-Au heterojunctions

    Science.gov (United States)

    Li, Kai; Ying, Xiangxiao; Wang, Juan; Wang, Jun; Jiang, Yadong; Liu, Zhijun

    2017-10-01

    As an emerging 2D material, graphene's several unique properties, such as high electron mobility, zero-bandgap and low density of states, present new opportunities for light detections. Here, we report on photovoltage responses of graphene-Au heterojunctions, which are made of monolayer graphene sheets atop Au electrodes designed as finger-shape and rectangle-shape, respectively. Besides confirming the critical role of space charge regions located at the graphene-Au boundary, photovoltage responses are measured in the visible to infrared spectral region with a cut-off wavelength at about 980 nm, which is likely imposed by the Pauli blocking of interband transition in the contact-doped graphene. The photoresponsivity is shown to decrease with increasing wavelength. A band diagram of the graphene-Au heterojunction is proposed to understand the photoresponse mechanism.

  20. Intense fluorescence of Au 20

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Chongqi; Harbich, Wolfgang; Sementa, Luca; Ghiringhelli, Luca; Apra, Edoardo; Stener, Mauro; Fortunelli, Alessandro; Brune, Harald

    2017-08-21

    Ligand-protected Au clusters are non-bleaching fluorescence markers in bio- and medical applications. We show that their fluorescence is an intrinsic property of the Au cluster itself. We find a very intense and sharp fluorescence peak located at λ =739.2 nm (1.68 eV) for Au20 clusters in a Ne matrix held at 6 K. The fluorescence reflects the HOMO-LUMO diabatic bandgap of the cluster. The cluster shows a very rich absorption fine structure reminiscent of well defined molecule-like quantum levels. These levels are resolved since Au20 has only one stable isomer (tetrahedral), therefore our sample is mono-disperse in cluster size and conformation. Density-functional theory (DFT) and time-dependent DFT calculations clarify the nature of optical absorptionand predict both main absorption peaks and intrinsic fluorescence in good agreement with experiment.

  1. PHENIX results on jets in d + Au

    Science.gov (United States)

    Hanks, J. Ali

    2016-12-01

    We present recently published results [A. Adare, et al., arxiv:arXiv:1509.04657] on fully reconstructed R=0.3 anti-kt jets measured in p+p and d+Au collisions at 200 GeV center-of-mass energy. The jet yields for four centrality classes along with the p+p reference are presented, as well as both the minimum bias RdAu and centrality dependent RdAu and RCP. We find that while the minimum bias RdA is consistent with unity, providing a strong constraint on models including cold-nuclear-matter effects or energy loss in small systems, the centrality dependent RdAu show a striking variation which presents a challenge to models attempting to describe the interplay between soft and hard processes in these systems.

  2. 22 CFR 62.31 - Au pairs.

    Science.gov (United States)

    2010-04-01

    ....31 Au pairs. (a) Introduction. This section governs Department of State-designated exchange visitor... requirements set forth at § 62.10 sponsors shall: (1) Inform all host families of the philosophy, rules, and...

  3. Unravelling Thiol’s Role in Directing Asymmetric Growth of Au Nanorod–Au Nanoparticle Dimers

    KAUST Repository

    Huang, Jianfeng

    2015-12-15

    Asymmetric nanocrystals have practical significance in nanotechnologies but present fundamental synthetic challenges. Thiol ligands have proven effective in breaking the symmetric growth of metallic nanocrystals but their exact roles in the synthesis remain elusive. Here, we synthesized an unprecedented Au nanorod-Au nanoparticle (AuNR-AuNP) dimer structure with the assistance of a thiol ligand. On the basis of our experimental observations, we unraveled for the first time that the thiol could cause an inhomogeneous distribution of surface strains on the seed crystals as well as a modulated reduction rate of metal precursors, which jointly induced the asymmetric growth of monometallic dimers. © 2015 American Chemical Society.

  4. Sex Chromosome Dosage Compensation in Heliconius Butterflies: Global yet Still Incomplete?

    Science.gov (United States)

    Walters, James R; Hardcastle, Thomas J; Jiggins, Chris D

    2015-09-02

    The evolution of heterogametic sex chromosomes is often-but not always-accompanied by the evolution of dosage compensating mechanisms that mitigate the impact of sex-specific gene dosage on levels of gene expression. One emerging view of this process is that such mechanisms may only evolve in male-heterogametic (XY) species but not in female-heterogametic (ZW) species, which will consequently exhibit "incomplete" sex chromosome dosage compensation. However, recent results suggest that at least some Lepidoptera (moths and butterflies) may prove to be an exception to this prediction. Studies in bombycoid moths indicate the presence of a chromosome-wide epigenetic mechanism that effectively balances Z chromosome gene expression between the sexes by reducing Z-linked expression in males. In contrast, strong sex chromosome dosage effects without any reduction in male Z-linked expression were previously reported in a pyralid moth, suggesting a lack of any such dosage compensating mechanism. Here we report an analysis of sex chromosome dosage compensation in Heliconius butterflies, sampling multiple individuals for several different adult tissues (head, abdomen, leg, mouth, and antennae). Methodologically, we introduce a novel application of linear mixed-effects models to assess dosage compensation, offering a unified statistical framework that can estimate effects specific to chromosome, to sex, and their interactions (i.e., a dosage effect). Our results show substantially reduced Z-linked expression relative to autosomes in both sexes, as previously observed in bombycoid moths. This observation is consistent with an increasing body of evidence that some lepidopteran species possess an epigenetic dosage compensating mechanism that reduces Z chromosome expression in males to levels comparable with females. However, this mechanism appears to be imperfect in Heliconius, resulting in a modest dosage effect that produces an average 5-20% increase in male expression relative

  5. "Dealloying" Phase Separation during Growth of Au on Ni(110)

    DEFF Research Database (Denmark)

    Nielsen, L. Pleth; Besenbacher, Flemming; Stensgaard, I.

    1995-01-01

    Combined scanning tunneling microscopy and ion-scattering studies have revealed a new "dealloying" phase transition during the growth of Au on Ni(110). The Au atoms, which initially alloy into the Ni(110) surface, phase separate into a vacancy-stabilized Au dimer-trimer chain structure at Au...

  6. Enantioselective separation on chiral Au nanoparticles.

    Science.gov (United States)

    Shukla, Nisha; Bartel, Melissa A; Gellman, Andrew J

    2010-06-30

    The surfaces of chemically synthesized Au nanoparticles have been modified with d- or l-cysteine to render them chiral and enantioselective for adsorption of chiral molecules. Their enantioselective interaction with chiral compounds has been probed by optical rotation measurements during exposure to enantiomerically pure and racemic propylene oxide. The ability of optical rotation to detect enantiospecific adsorption arises from the fact that the specific rotation of polarized light by (R)- and (S)-propylene oxide is enhanced by interaction with Au nanoparticles. This effect is related to previous observations of enhanced circular dichroism by Au nanoparticles modified by chiral adsorbates. More importantly, chiral Au nanoparticles modified with either d- or l-cysteine selectively adsorb one enantiomer of propylene oxide from a solution of racemic propylene oxide, thus leaving an enantiomeric excess in the solution phase. Au nanoparticles modified with l-cysteine (d-cysteine) selectively adsorb the (R)-propylene oxide ((S)-propylene oxide). A simple model has been developed that allows extraction of the enantiospecific equilibrium constants for (R)- and (S)-propylene oxide adsorption on the chiral Au nanoparticles.

  7. Apprentissages techniques : L'apprentissage au CERN

    CERN Document Server

    2004-01-01

    APPRENTISSAGES TECHNIQUES GESTION ET DEVELOPPEMENT DU PERSONNEL HR/PMD L'APPRENTISSAGE AU CERN pour les professions d'électronicien(ne) et de laborantin(e) en physique L'apprentissage au CERN est régi par les lois, règlements et contrats en vigueur dans le Canton de Genève. En cas de réussite à l'examen de fin d'apprentissage, les apprentis obtiennent le Certificat Fédéral de Capacité Suisse (CFC). 7 places au total sont ouvertes au recrutement pour les deux professions. L'apprentissage dure 4 ans. Minima requis pour faire acte de candidature : • avoir au moins 15 ans et moins de 21 ans à la date de début de l'apprentissage • avoir terminé la scolarité obligatoire, au minimum 9ème du Cycle d'orientation genevois (3ème en France) • être ressortissant d'un pays membre du CERN (Allemagne, Autriche, Belgiqu...

  8. Systematic Measurements of Identified Particle Spectra in pp, d+Au and Au+Au Collisions from STAR

    Energy Technology Data Exchange (ETDEWEB)

    STAR Coll

    2009-04-11

    Identified charged particle spectra of {pi}{sup {+-}}, K{sup {+-}}, p and {bar p} at mid-rapidity (|y| < 0.1) measured by the dE/dx method in the STAR-TPC are reported for pp and d + Au collisions at {radical}s{sub NN} = 200 GeV and for Au + Au collisions at 62.4 GeV, 130 GeV, and 200 GeV. Average transverse momenta, total particle production, particle yield ratios, strangeness and baryon production rates are investigated as a function of the collision system and centrality. The transverse momentum spectra are found to be flatter for heavy particles than for light particles in all collision systems; the effect is more prominent for more central collisions. The extracted average transverse momentum of each particle species follows a trend determined by the total charged particle multiplicity density. The Bjorken energy density estimate is at least several GeV/fm{sub 3} for a formation time less than 1 fm/c. A significantly larger net-baryon density and a stronger increase of the net-baryon density with centrality are found in Au + Au collisions at 62.4 GeV than at the two higher energies. Antibaryon production relative to total particle multiplicity is found to be constant over centrality, but increases with the collision energy. Strangeness production relative to total particle multiplicity is similar at the three measured RHIC energies. Relative strangeness production increases quickly with centrality in peripheral Au + Au collisions, to a value about 50% above the pp value, and remains rather constant in more central collisions. Bulk freeze-out properties are extracted from thermal equilibrium model and hydrodynamics-motivated blast-wave model fits to the data. Resonance decays are found to have little effect on the extracted kinetic freeze-out parameters due to the transverse momentum range of our measurements. The extracted chemical freeze-out temperature is constant, independent of collision system or centrality; its value is close to the predicted phase

  9. 78 FR 3900 - Generic Drug User Fee-Active Pharmaceutical Ingredient and Finished Dosage Form Facility Fee...

    Science.gov (United States)

    2013-01-17

    ... Finished Dosage Form Facility Fee Rates for Fiscal Year 2013 AGENCY: Food and Drug Administration, HHS... drug active pharmaceutical ingredient (API) and finished dosage form (FDF) facilities user fees for... applications in the backlog as of October 1, 2012, on finished dosage form (FDF) and active pharmaceutical...

  10. Accord entre l'Organisation Européenne pour la Recherche Nucléaire, le Conseil Fédéral Suisse et le Gouvernement de la République Française relatif à la protection contre les rayonnements ionisants et à la sûreté des installations de l'Organisation Européenne pour la Recherche Nucléaire

    CERN Document Server

    2010-01-01

    Accord entre l'Organisation Européenne pour la Recherche Nucléaire, le Conseil Fédéral Suisse et le Gouvernement de la République Française relatif à la protection contre les rayonnements ionisants et à la sûreté des installations de l'Organisation Européenne pour la Recherche Nucléaire

  11. Fully Cationized Gold Clusters: Synthesis of Au25(SR+)18.

    Science.gov (United States)

    Ishida, Yohei; Narita, Kunihiro; Yonezawa, Tetsu; Whetten, Robert L

    2016-10-06

    Although many thiolate-protected Au clusters with different numbers of Au atoms and a variety of thiolate ligands have been synthesized, to date there has been no report of a fully cationized Au cluster protected with cationic thiolates. Herein, we report the synthesis of the first member of a new series of thiolate-protected Au cluster molecules: a fully cationized Au 25 (SR + ) 18 cluster.

  12. Suppression of ϒ production in d+Au and Au+Au collisions at √(s{sub NN})=200 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Adamczyk, L. [AGH University of Science and Technology, Cracow (Poland); Adkins, J.K. [University of Kentucky, Lexington, KY, 40506-0055 (United States); Agakishiev, G. [Joint Institute for Nuclear Research, Dubna, 141 980 (Russian Federation); Aggarwal, M.M. [Panjab University, Chandigarh 160014 (India); Ahammed, Z. [Variable Energy Cyclotron Centre, Kolkata 700064 (India); Alekseev, I. [Alikhanov Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Alford, J. [Kent State University, Kent, OH 44242 (United States); Anson, C.D. [Ohio State University, Columbus, OH 43210 (United States); Aparin, A. [Joint Institute for Nuclear Research, Dubna, 141 980 (Russian Federation); Arkhipkin, D.; Aschenauer, E.C. [Brookhaven National Laboratory, Upton, NY 11973 (United States); Averichev, G.S. [Joint Institute for Nuclear Research, Dubna, 141 980 (Russian Federation); Balewski, J. [Massachusetts Institute of Technology, Cambridge, MA 02139-4307 (United States); Banerjee, A. [Variable Energy Cyclotron Centre, Kolkata 700064 (India); Barnovska, Z. [Nuclear Physics Institute AS CR, 250 68 Řež/Prague (Czech Republic); Beavis, D.R. [Brookhaven National Laboratory, Upton, NY 11973 (United States); Bellwied, R. [University of Houston, Houston, TX, 77204 (United States); Bhasin, A. [University of Jammu, Jammu 180001 (India); Bhati, A.K. [Panjab University, Chandigarh 160014 (India); Bhattarai, P. [University of Texas, Austin, TX 78712 (United States); and others

    2014-07-30

    We report measurements of ϒ meson production in p+p, d+Au, and Au+Au collisions using the STAR detector at RHIC. We compare the ϒ yield to the measured cross section in p+p collisions in order to quantify any modifications of the yield in cold nuclear matter using d+Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p+p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for ϒ(1S+2S+3S) in the rapidity range |y|<1 in d+Au collisions of R{sub dAu}=0.79±0.24(stat.)±0.03(syst.)±0.10(p+p syst.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au+Au collisions, we measure a nuclear modification factor of R{sub AA}=0.49±0.1(stat.)±0.02(syst.)±0.06(p+psyst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state ϒ mesons in Au+Au collisions. The additional suppression in Au+Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d+Au is still needed before any definitive statements about the nature of the suppression in Au+Au can be made.

  13. 100-MeV proton beam intensity measurement by Au activation analysis using {sup 197}Au(p, pn){sup 196}Au and {sup 197}Au(p, p3n){sup 194}Au reactions

    Energy Technology Data Exchange (ETDEWEB)

    Mokhtari Oranj, Leila [Division of Advanced Nuclear Engineering, POSTECH, Pohang 37673 (Korea, Republic of); Jung, Nam-Suk; Oh, Joo-Hee [Pohang Accelerator Laboratory, POSTECH, Pohang 37673 (Korea, Republic of); Lee, Hee-Seock, E-mail: lee@postech.ac.kr [Pohang Accelerator Laboratory, POSTECH, Pohang 37673 (Korea, Republic of)

    2016-05-15

    The proton beam intensity of a 100-MeV proton linac at the Korea Multi-purpose Accelerator Complex (KOMAC) was measured by an Au activation analysis using {sup 197}Au(p, pn){sup 196}Au and {sup 197}Au(p, p3n){sup 194}Au reactions to determine the accuracy and precision of beam intensity measurement using Gafchromic film dosimetry method. The target, irradiated by 100-MeV protons, was arranged in a stack consisting of Au, Al foils and Pb plates. The yields of produced radio-nuclei in Au foils were obtained by gamma-ray spectroscopy. The FLUKA code was employed to calculate the energy spectrum of protons onto the front surface of Au foils located at three different depth points of the target and also to investigate the condition of incident beam on the target. A good agreement was found between the beam intensity measurements using the activation analysis method at three different depth points of the target. An excellent agreement was also observed between the beam intensity measurements using the Au activation analysis method and the dosimetry method using Gafchromic film.

  14. Development of agar diffusion method for dosage of gramicidin

    Directory of Open Access Journals (Sweden)

    Ana Gabriela Reis Solano

    2011-09-01

    Full Text Available Gramicidin, an antimicrobial peptide active against Gram positive bacteria, is commonly used in pharmaceutical preparations for topical use. Considering that only the turbidimetric method has been described in the literature, the present study sought to develop and validate an agar diffusion method for the dosage of gramicidin. The method was developed and validated using the Kocuria rhizophila ATCC 9341 as a test microorganism. Two designs were used: a 3x3 parallel-line model, and a 5x1 standard curve. The validation demonstrated that the method follows the linear model (r²= 0.994, presenting a significant regression between the zone diameter of growth inhibition and the logarithm of the concentration within the range of 5 to 25.3 µg/mL. The results obtained for both designs were precise, having a relative standard deviation (R.S.D. for intra-day precision of 0.81 for the 3x3 assay and 1.90 for the 5x1 assay. For the inter-day precision, the R.S.D. was 1.35 for the 3x3 and 2.64 for the 5x1. The accuracy was verified and results confirmed to be accurate, having a tolerance interval of 95%, which lay within permitted limits and appropriate trueness. In addition, the method was considered selective, with limit of detection and upper and lower limits of quantification of 2.00, 5.00 and 25.3 µg/mL, respectively. No difference in precision between the designs used in the agar diffusion method was evident (p>0.05. The method proved to be appropriate for the microbiological dosage of the raw material gramicidin.A gramicidina, um peptídeo antimicrobiano ativo contra bactérias Gram positivo, é utilizada em preparações farmacêuticas de uso tópico. Neste trabalho procurou-se desenvolver e validar outro método para o doseamento de gramicidina tendo em vista que somente o método turbidimétrico é descrito. O método de difusão em ágar foi desenvolvido e validado utilizando como microrganismo teste Kocuria rhizophila ATCC 9341. Foram utilizados

  15. Nanocrystals: From Raw Material to the Final Formulated Oral Dosage Form--A Review.

    Science.gov (United States)

    Scholz, Patrik; Keck, Cornelia M

    2015-01-01

    Many new developed drug actives are poorly soluble, therefore the need to increase the solubility of these actives arises. Nanosuspensions are fast and easy to produce, enhance the bioavailability of poorly soluble drugs and feature many beneficial characteristics. However, nanocrystals in suspension form are physically metastable. Furthermore, the application of nanocrystal suspensions has no retarding effects. To overcome long term stability issues and open up a variety of options for controlled release, nanocrystals can be converted into solid dosage forms by different methods with different outcomes and features. Transformation of nanosuspensions into solid dosage forms opens up manifold options for the development of dosage forms with tailor-made drug release profiles. This review focuses on nanocrystal properties, established and new production techniques, as well as state of the art techniques for transformation of nanosuspensions into solid dosage forms. Nanocrystal technology is already today used in several solid products and holds great potential for future uses.

  16. A new way of solid dosage form samples preparation for SEM and FTIR using microtome.

    Science.gov (United States)

    Šimek, Michal; Grünwaldová, Veronika; Kratochvíl, Bohumil

    2014-06-01

    Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuracy and allow obtaining a lot of information about the original product. Scanning electron microscopy (SEM) is used for observation and assessing individual layers, core and surface of solid dosage forms. Fourier transform infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient.

  17. a Step Toward Development of Printable Dosage Forms for Poorly Soluble Drugs

    DEFF Research Database (Denmark)

    Raijada, Dhara; Genina, Natalja; Fors, Daniela

    2013-01-01

    The purpose of this study was to formulate printable dosage forms for a poorly soluble drug (piroxicam; PRX) and to gain understanding of critical parameters to be considered during development of such dosage forms. Liquid formulations of PRX were printed on edible paper using piezoelectric inkjet...... printing (PIJ) and impression printing (flexography). The printed dosage forms were characterized using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and the amount of drug was determined using high-performance liquid chromatography. Solutions of PRX in polyethylene...... glycol 400 (PEG-400):ethanol (40:60) and in PEG-400 were found to be optimal formulations for PIJ and flexography, respectively. SEM-EDX analysis revealed no visible solid particles on the printed dosage forms indicating the drug most likely remained in solution after printing. More accurate drug...

  18. [Analysis on dosage form theory and current application situation of traditional Chinese medicine pill].

    Science.gov (United States)

    Zhang, Zhen; Gao, Tian-Hui; Fu, Chao-Mei; Zhang, Jin-Ming; Shi, Jin-Feng; He, Yao; Yin, Heng; Jiang, Mao-Yuan; Li, Jie; Gao, Fei

    2017-06-01

    Traditional Chinese medicine(TCM) pill, the most representative and successive dosage form, is called as one of the four classical TCM dosage forms. "Pills could keep the lasting and lenitive therapeutic efficacy for a long period" is the most classical dosage form theory, showing a guidance significance in making recipe, preparations and clinic application. In this article, we would elucidate the inheritance and development significance of TCM pills in three key points, including dosage form theory, pharmaceutical preparation technology and clinic usage based on the pharmaceutics connotation of this theory. From this, it can provide the basis for researches on pills mechanism, material basis and mode of action in clinical application. Copyright© by the Chinese Pharmaceutical Association.

  19. Evaluation of performance of co crystals of mefloquine hydrochloride in tablet dosage form.

    Science.gov (United States)

    Shete, A S; Yadav, A V; Murthy, M S

    2013-05-01

    The objective of present investigation was to evaluate performance of cocrystals of Mefloquine Hydrochloride (MFL) in tablet dosage form. Our previous investigation showed significant effect of cocrystal formers on improving the solubility and dissolution rate of Mefloquine hydrochloride by cocrystallization method when prepared by solution cocrystallization method. Prepared cocrystals of MFL with different ratio of cocrystal formers were incorporated in tablet dosage form and evaluated for micrometric properties, drug content, hardness, disintegration test, vitro dissolution studies and stability studies. Performance was compared with laboratory prepared tablet of MFL 250 mg. The considerable improvement in the dissolution rate was observed in case of cocrystals based tablets than pure MFL tablets. So we can incorporate cocrystals in tablet dosage form to enhance in vitro and in vivo performance. To the best of our knowledge, this is the first report, cocrystals has been evaluated in tablet dosage form.

  20. Tissue distribution of amiodarone and desethylamiodarone in rats after repeated oral administration of various amiodarone dosages

    NARCIS (Netherlands)

    Plomp, T. A.; Wiersinga, W. M.; Maes, R. A.

    1985-01-01

    Tissue distribution of amiodarone (Cordarone) and desethylamiodarone in the rat was investigated after repeated oral application of various dosages of the drug. Serum and tissue concentrations ofBamiodarone and desethylamiodarone were assessed by high-performance liquid chromatography. The

  1. Dosage dependent hormonal counter regulation to combination therapy in patients with left ventricular dysfunction

    DEFF Research Database (Denmark)

    Galløe, A.M.; Skagen, K.; Christensen, Niels Juel

    2006-01-01

    The present study attempts to assess the efficacy combination therapy for heart failure. Genuine dose-response studies on combination therapy are not available and published studies involved adding one drug on top of 'usual treatment'. Sixteen different dosage combinations of trandolapril...... with the maximal effect at 0.5 mg daily. Both drugs significantly increased renin concentration with a significant potentiating interaction. It was not possible to detect beneficial effects of combination therapies. The optimal dosage of Bumetanide appeared to be 0.5 mg twice daily based on its effect on quality...... of life and weight loss. Estimated by the reduction in systolic blood pressure the optimal dosage of Trandolapril appeared to be 0.5 mg once daily. CONCLUSIONS: It appears that patients should be given less than the usually recommended dosages. Patients may be treated with a low dose loop diuretic...

  2. The relationship between maintenance dosages of three vitamin K antagonists : Acenocoumarol, warfarin and phenprocoumon

    NARCIS (Netherlands)

    van Leeuwen, Yvonne; Rosendaal, Frits R; van der Meer, Felix J M

    2008-01-01

    INTRODUCTION: Vitamin K antagonists of the coumarin type are widely used oral anticoagulants. OBJECTIVE: We developed a transition algorithm for the maintenance dosages of three frequently used coumarins: warfarin, phenprocoumon and acenocoumarol. METHODS: The study was conducted at the Leiden

  3. Is the Defined Daily Dose system a reliable tool for standardizing antipsychotic dosages?

    NARCIS (Netherlands)

    Nosè, Michela; Tansella, Michele; Thornicroft, Graham; Schene, Aart; Becker, Thomas; Veronese, Antonio; Leese, Morven; Koeter, Maarten; Angermeyer, Matthias; Barbui, Corrado

    2008-01-01

    The present study was carried out to establish whether the Defined Daily Doses (DDDs) system could be reliably applied to standardize antipsychotic dosages. Initially, the relationship between antipsychotic doses expressed as DDDs, chlorpromazine equivalents (CPZEs) and percentages of the British

  4. Toward hybrid Au nanorods @ M (Au, Ag, Pd and Pt) core-shell heterostructures for ultrasensitive SERS probes

    Science.gov (United States)

    Xie, Xiaobin; Gao, Guanhui; Kang, Shendong; Lei, Yanhua; Pan, Zhengyin; Shibayama, Tamaki; Cai, Lintao

    2017-06-01

    Being able to precisely control the morphologies of noble metallic nanostructures is of essential significance for promoting the surface-enhanced Raman scattering (SERS) effect. Herein, we demonstrate an overgrowth strategy for synthesizing Au @ M (M = Au, Ag, Pd, Pt) core-shell heterogeneous nanocrystals with an orientated structural evolution and highly improved properties by using Au nanorods as seeds. With the same reaction condition system applied, we obtain four well-designed heterostructures with diverse shapes, including Au concave nanocuboids (Au CNs), Au @ Ag crystalizing face central cube nanopeanuts, Au @ Pd porous nanocuboids and Au @ Pt nanotrepangs. Subsequently, the exact overgrowth mechanism of the above heterostructural building blocks is further analysed via the systematic optimiziation of a series of fabrications. Remarkably, the well-defined Au CNs and Au @ Ag nanopeanuts both exhibit highly promoted SERS activity. We expect to be able to supply a facile strategy for the fabrication of multimetallic heterogeneous nanostructures, exploring the high SERS effect and catalytic activities.

  5. Leading Hadron Production in d+Au and 3He+Au collisions in the PHENIX experiment

    Science.gov (United States)

    Sakaguchi, Takao; Phenix Collaboration

    2017-08-01

    Neutral pions have been measured in 3He+Au collisions at √{sNN } = 200 GeV up to 20 GeV/c in the RHIC Year-2014 run. The nuclear modification factor RAA was measured and compared with that from d+Au collisions. The integrated RAA as a function of Npart was calculated for d+Au, 3He+Au and Au+Au collisions at √{sNN } = 200 GeV, and found to converge for Npart > 12, while a clear system ordering RdAu >RHeAu >RAuAu was observed for Npart > 12. The fractional momentum loss for the most central 3He+Au collisions was also estimated.

  6. Reduction of Phenmedipham + Desmedipham + Ethofumesate Herbicides Dosage Based on Application Timing in Sugar Beet

    Directory of Open Access Journals (Sweden)

    Valiyolah Anabestani

    2017-04-01

    Full Text Available An experiment was conducted to study possible reduction of concentration (dose of phenmedipham + desmedipham + ethofumesate herbicides at different application times to control weeds in sugar beet field. Thus, a factorial experiment based on complete randomized block design with three replications was performed at Sabzevar, Khorasan-e-Razavi in 2013. Factors consisted of herbicide dosages (control, 75% of the recommended dosage, and 125% of recommended dosage and application times at 2-4, 4-8 and 8-12 leaf stages of sugar beet. Herbicide used in the experiment was phenmedipham (9.2% + desmedipham (7.2% + ethofumesate (11.3% (PROGRESS OF BETAMIX as 877 ga.i ha-1 27.4 EC. The results indicated that the delayed application of herbicide increased weed density by 55.92% and weed dry matter by 33%. Application of herbicide at 4-8 leaf stage produced highest root and sugar yields. Root impurities were not affected by the time of herbicide application. Used of 125% of recommended dosage resulted in lowest weed density and weed dry matter and highest root and sugar yields. Impure sugar percentage and K content was not affected by herbicide dosage. Other root quality characteristics were not statistically significant different between the recommended dose 125% of recommended dosages. Results as a wholes suggested that at early growth stage of sugar beet (2-4 leaf stage lower herbicide dosage and at later growth stage of sugar beet (8-12 leaf stage higher herbicide dosage may produce highest root yield of sugar beet.

  7. Effect of Starch Dosage on the Properties of Modified Ground Calcium Carbonate

    OpenAIRE

    Huiming Fan,; Binfeng Xu; Jianan Liu; Cheng Zhang

    2014-01-01

    Ground calcium carbonate (GCC) was modified with a starch/sodium stearate complex and used to prepare different coating weights by controlling the starch dosages. Modified GCC was characterized by scanning electron microscopy (SEM) and particle size analysis. The effects of starch dosage (based on the dry weight of GCC) on the size of modified GCC, the coating weight of modified GCC, and the utilization rate of starch were evaluated. Four kinds of modified GCC with different coating weights o...

  8. Antidepressant dosage taken by patients with bipolar disorder: factors associated with irregularity.

    Science.gov (United States)

    Bauer, Rita; Glenn, Tasha; Alda, Martin; Sagduyu, Kemal; Marsh, Wendy; Grof, Paul; Munoz, Rodrigo; Murray, Greg; Ritter, Philipp; Lewitzka, Ute; Severus, Emanuel; Whybrow, Peter C; Bauer, Michael

    2013-01-01

    This study analyzed regularity in the daily dosage of antidepressants taken by patients with bipolar disorder and identified the factors associated with irregularity. Daily self-reported medication dosage taken and mood ratings were available from 144 patients who received treatment as usual. All 144 patients took the same antidepressant for at least 100 days. One hundred eleven of these patients were also taking a mood stabilizer. Approximate entropy (ApEn) was used to measure serial regularity in daily dosage. Regularity is the tendency that values within a time series remain the same on incremental comparisons. Drug holidays (missing three or more consecutive days) were also determined. Generalized estimating equations (GEE) were used to estimate if any demographic or clinical variables were associated with regularity. Although the mean percent of days missing doses was only 18.6%, there was a wide range of regularity in the daily antidepressant dosage. Drug holidays were common, occurring in 41% of the analyses. Factors significantly associated with irregularity were as follows: total number of psychotropic medications (p = 0.005), pill burden (p = 0.005), and depression (p = 0.015). Neither the percent of days missing doses nor the drug holidays were associated with any demographic or clinical factors. For patients taking both antidepressants and mood stabilizers, there was no significant difference in regularity in daily dosage between these drugs. There can be considerable irregularity in daily dosage despite a low percent of days missing doses. Medication regimen complexity and depressed mood are associated with increased irregularity. Daily regularity in drug dosage may be more dependent on the individual than on the specific drug. Research on the clinical impact of irregularity in daily dosage of antidepressants is needed.

  9. Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review

    OpenAIRE

    Blackshields, Caroline A.; Abina M Crean

    2017-01-01

    There has been a noticeable shift from pharmaceutical batch processing towards a more continuous mode of manufacture for solid oral dosage forms. Continuous solid oral dose processes would not be possible in the absence of a highly accurate feeding system. The performance of feeders defines the content of formulations and is therefore a critical operation in continuous manufacturing of solid dosage forms. It was the purpose of this review to review the role of the initial powder feeding step ...

  10. Methotrexate Dosage Reduction Upon Adalimumab Initiation: Clinical and Ultrasonographic Outcomes from the Randomized Noninferiority MUSICA Trial.

    Science.gov (United States)

    Kaeley, Gurjit S; Evangelisto, Amy M; Nishio, Midori J; Goss, Sandra L; Liu, Shufang; Kalabic, Jasmina; Kupper, Hartmut

    2016-08-01

    To examine the clinical and ultrasonographic (US) outcomes of reducing methotrexate (MTX) dosage upon initiating adalimumab (ADA) in MTX-inadequate responders with moderately to severely active rheumatoid arthritis (RA). MUSICA (NCT01185288) was a double-blind, randomized, parallel-arm study of 309 patients with RA receiving MTX ≥ 15 mg/week for ≥ 12 weeks before screening. Patients were randomized to high dosage (20 mg/week) or low dosage (7.5 mg/week) MTX; all patients received 40 mg open-label ADA every other week for 24 weeks. The primary endpoint was Week 24 mean 28-joint Disease Activity Score based on C-reactive protein (DAS28-CRP) to test for noninferiority of low-dosage MTX using a 15% margin. US images were scored using a 10-joint semiquantitative system incorporating OMERACT definitions for pathology, assessing synovial hypertrophy, vascularity, and bony erosions. Rapid improvement in clinical indices was observed in both groups after addition of ADA. The difference in mean DAS28-CRP (0.37, 95% CI 0.07-0.66) comparing low-dosage (4.12, 95% CI 3.88-4.34) versus high-dosage MTX (3.75, 95% CI 3.52-3.97) was statistically significant and non-inferiority was not met. Statistically significant differences were not detected for most clinical, functional, and US outcomes. Pharmacokinetic and safety profiles were similar. In MUSICA, Week 24 mean DAS28-CRP, the primary endpoint, did not meet non-inferiority for the low-dosage MTX group. Although the differences between the 2 MTX dosage groups were small, our study findings did not support routine MTX reduction in MTX inadequate responders initiating ADA.

  11. INDRA at GSI; INDRA au GSI

    Energy Technology Data Exchange (ETDEWEB)

    Bougault, R.; Bocage, F.; Durand, D.; Lopez, O.; Steckmeyer, J.C.; Tamain, B.; Vient, E. [Lab. de Physique Corpusculaire, Caen Univ., 14 (France); Collaboration INDRA: IPN-Orsay, DAPNIA-Saclay, SUBATECH-Nantes, IPN- Lyon, GANIL-Caen

    1997-12-31

    In connection to the decision of installing the INDRA detector by the SIS synchrocyclotron at GSI (Darmstadt, Germany) the report presents the tasks taken into account by the LPC-Caen. These refer to the detector displacement and (mechanical) installation at GSI, the tests before beam (i.e. electronics acquisition software, detectors, etc.) as well as the data acquisition and processing. The physical pro-arguments mention the possibility of disposing of heavy ion beams in a range from 50 MeV to several GeV/nucleon so extending the study of multifragmentation done at GANIL between 30 and 90 MeV/nucleon. More specific, the scientific program of INDRA at GSI inserts studies between those done at around Fermi energy, were the reaction mechanisms are of type of deep inelastic scattering/incomplete fusion, and the studies in the relativistic energy domain where the individual properties of nucleons and transparency of nuclear matter implies mechanisms of the participant-spectator type (fire-ball creation). Also mentioned as fields of extensive studies are: the multifragmentation and its fundamental relation with the nuclear matter equation of state, the role of reaction dynamics in the appearance of collective effects of the radial flow type and its relations with the nuclear compressibility and phase transitions and the thermodynamics of nuclear matter. It appeared that the heavy systems Xe + Sn and Au + Au are the best compromise for the different topics to be approached. The bombarding energies extend from 50 to 150 MeV/nucleon. The report ends with the table giving for six heavy systems (Xe + Sn, Au + Au, C + Au, Ar + Au and P + Au) the required bombarding energies 15 refs.

  12. The extraction characteristic of Au-Ag from Au concentrate by thiourea solution

    Science.gov (United States)

    Kim, Bongju; Cho, Kanghee; On, Hyunsung; Choi, Nagchoul; Park, Cheonyoung

    2013-04-01

    The cyanidation process has been used commercially for the past 100 years, there are ores that are not amenable to treatment by cyanide. Interest in alternative lixiviants, such as thiourea, halogens, thiosulfate and malononitrile, has been revived as a result of a major increase in gold price, which has stimulated new developments in extraction technology, combined with environmental concern. The Au extraction process using the thiourea solvent has many advantages over the cyanidation process, including higher leaching rates, faster extraction time and less than toxicity. The purpose of this study was investigated to the extraction characteristic of Au-Ag from two different Au concentrate (sulfuric acid washing and roasting) under various experiment conditions (thiourea concentration, pH of solvent, temperature) by thiourea solvent. The result of extraction experiment showed that the Au-Ag extraction was a fast extraction process, reaching equilibrium (maximum extraction rate) within 30 min. The Au-Ag extraction rate was higher in the roasted concentrate than in the sulfuric acid washing. The higher the Au-Ag extraction rate (Au - 70.87%, Ag - 98.12%) from roasted concentrate was found when the more concentration of thiourea increased, pH decreased and extraction temperature increased. This study informs extraction method basic knowledge when thiourea was a possibility to eco-/economic resources of Au-Ag utilization studies including the hydrometallurgy.

  13. Multistep production of eta and hard pi(0) mesons in subthreshold Au-Au collisions

    NARCIS (Netherlands)

    Appenheimer, M; Averbeck, R; Charbonnier, Y; Diaz, J; Doppenschmidt, A; Hejny, [No Value; Hlavac, S; Holzmann, R; Kugler, A; Lohner, H; Marin, A; Metag, [No Value; Novotny, R; Ostendorf, RW; Pleskac, R; Schubert, A; Schutz, Y; Simon, RS; Stratmann, R; Stroher, H; Tlusty, P; Vogt, PH; Wagner, [No Value; Weiss, J; Wilschut, HW; Wissmann, F; Wolf, M

    1998-01-01

    The neutral pi(o) and eta mesons are studied in Au-197-Au-197 collisions at an incident energy of 800A MeV, substantially below the threshold for eta production in N-N collisions. While the gross pi(o) multiplicity increases almost linearly with the number of participant nucleons, the multiplicities

  14. Au/ZnO nanoarchitectures with Au as both supporter and antenna of visible-light

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Tianyu; Chen, Wei; Hua, Yuxiang; Liu, Xiaoheng, E-mail: xhliu@mail.njust.edu.cn

    2017-01-15

    Highlights: • An inversed Au/ZnO nanostructure was fabricated with ZnO loaded onto Au. • The Au/ZnO nanocomposites showed enhanced properties in visible-light photocatalysis. • The SPR effect of Au was considered important for visible-light photocatalysis. - Abstract: In this paper, we fabricate Au/ZnO nanostructure with smaller ZnO nanoparticles loaded onto bigger gold nanoparticles via combining seed-mediated method and sol-gel method. The obtained Au/ZnO nanocomposites exhibit excellent properties in photocatalysis process like methyl orange (MO) degradation and oxidative conversion of methanol into formaldehyde under visible light irradiation. The enhanced properties were ascribed to the surface plasmon resonance (SPR) effect of Au nanoparticles, which could contribute to the separation of photo-excited electrons and holes and facilitate the process of absorbing visible light. This paper contributes to the emergence of multi-functional nanocomposites with possible applications in visible-light driven photocatalysts and makes the Au/ZnO photocatalyst an exceptional choice for practical applications such as environmental purification of organic pollutants in aqueous solution and the synthesis of fine chemicals and intermediates.

  15. Using supported Au nanoparticles as starting material for preparing uniform Au/Pd bimetallic catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Villa, Alberto [Universita di Milano, Italy; Prati, Laura [Universita di Milano, Italy; Su, Dangshen [Fritz Haber Institute of the Max Planck Society, Berlin, Germany; Wang, Di [Fritz Haber Institute of the Max Planck Society, Berlin, Germany; Veith, Gabriel M [ORNL

    2010-01-01

    One of the best methods for producing bulk homogeneous (composition) supported bimetallic AuPd clusters involves the immobilization of a protected Au seed followed by the addition of Pd. This paper investigates the importance of this gold seed in controlling the resulting bimetallic AuPd clusters structures, sizes and catalytic activities by investigating three different gold seeds. Uniform Au-Pd alloy were obtained when a steric/electrostatic protecting group, poly(vinyl alcohol) (PVA), was used to form the gold clusters on activated carbon (AC). In contrast Au/AC precursors prepared using Au nanoparticles with only electrostatic stabilization (tetrakis(hydroxypropyl)phosphonium chloride (THPC)), or no stabilization (magnetron sputtering) produced inhomogeneous alloys and segregation of the gold and palladium. The uniform alloyed catalyst (Pd{at}Au{sub PVA}/AC) is the most active and selective catalyst, while the inhomogenous catalysts are less active and selective. Further study of the PVA protected Au clusters revealed that the amount of PVA used is also critical for the preparation of uniform alloyed catalyst, their stability, and their catalytic activity.

  16. Directed flow of antiprotons in Au+Au collisions at AGS

    OpenAIRE

    Barrette, J.; Bellwied, R.; Bennett, S.; Bersch, R.; Braun-Munzinger, P.; Chang, W. C.; Cleland, W. E.; Clemen, M.; Cole, J.; Cormier, T. M.; Dai, Y.; David, G.; Dee, J.; Dietzsch, O.; Drigert, M.

    2000-01-01

    Directed flow of antiprotons is studied in Au+Au collisions at a beam momentum of 11.5A GeV/c. It is shown that antiproton directed flow is anti-correlated to proton flow. The measured transverse momentum dependence of the antiproton flow is compared with predictions of the RQMD event generator.

  17. Stability of gold cages (Au16 and Au17) at finite temperature

    Indian Academy of Sciences (India)

    2015-11-27

    Nov 27, 2015 ... We have employed ab initio molecular dynamics to investigate the stability of the smallest gold cages, namely Au16 and Au17, at finite temperatures. First, we obtain the ground state structure along with at least 50 distinct isomers for both the clusters. This is followed by the finite temperature simulations of ...

  18. Charged particle density distributions in Au·Au collisions at ...

    Indian Academy of Sciences (India)

    Charged particle pseudorapidity distributions have been measured in Au·Au collisions using the BRAHMS ... Relativistic heavy-ion collisions; charged hadron production; pseudorapidity distribu- tions; centrality .... the predictions of two different theoretical models: (i) the high density gluon saturation model of Kharzeev and ...

  19. Low-temperature solution synthesis of the non-equilibrium ordered intermetallic compounds Au3Fe, Au3Co, and Au3Ni as nanocrystals.

    Science.gov (United States)

    Vasquez, Yolanda; Luo, Zhiping; Schaak, Raymond E

    2008-09-10

    Alloys and intermetallic compounds of Au with the 3d transition metals Fe, Co, and Ni are nonequilibrium phases that have many useful potential applications as catalytic, magnetic, optic, and multifunctional magneto-optic materials. However, the atomically ordered Au-M (M = Fe, Co, Ni) intermetallics are particularly elusive from a synthetic standpoint. Here we report the low-temperature solution synthesis of the L12 (Cu3Au-type) intermetallic compounds Au3Fe, Au3Co, and Au3Ni using n-butyllithium as a reducing agent. Reaction pathway studies for the Au3Co system indicate that Au nucleates first, followed by Co incorporation to form the intermetallic. The nonequilibrium intermetallic nanocrystals have been characterized by powder XRD, TEM, EDS, selected area electron diffraction, and nanobeam electron diffraction, which collectively confirm the compositions and superlattice structures.

  20. Genome-wide association analysis to predict optimal antipsychotic dosage in schizophrenia: a pilot study.

    Science.gov (United States)

    Koga, Arthur T; Strauss, John; Zai, Clement; Remington, Gary; De Luca, Vincenzo

    2016-03-01

    In recent years, several studies have investigated genetic polymorphisms of antipsychotic drug-metabolizing enzymes and receptors. However, most studies focused on drug response and very few have investigated the genetic influence on antipsychotic dosage. The aim of the present study is to test the association between antipsychotic dosages at genome-wide level. The current dosage of antipsychotic medications was collected from 79 schizophrenia patients. The dosage was standardized using three different methods: chlorpromazine equivalent (CPZe), defined daily dose (DDD), and percentage of maximum dose (PM %). The patients were then genotyped using the Illumina HumanOmni2.5-8 BeadChip Kit. All markers were screened for significance using linear regression, and the p values were visualized using a Manhattan plot. The genome-wide analysis showed that the top Single-Nucleotide Polymorphisms (SNPs) associated with dosage variation were rs981975 on chromosome 14 for CPZe, rs4470690 on chromosome 4 for PM %, and rs79323383 on chromosome 8 for DDD. However, no genome-wide significantly associated SNPs were identified. In this pilot sample, we found promising trends for pharmacodynamic targets associated with antipsychotic dosage. Therefore, studies combining large prescription databases may identify genetic predictors to adjust the dose of antipsychotic medication.

  1. Definition of variables required for comprehensive description of drug dosage and clinical pharmacokinetics.

    Science.gov (United States)

    Medem, Anna V; Seidling, Hanna M; Eichler, Hans-Georg; Kaltschmidt, Jens; Metzner, Michael; Hubert, Carina M; Czock, David; Haefeli, Walter E

    2017-05-01

    Electronic clinical decision support systems (CDSS) require drug information that can be processed by computers. The goal of this project was to determine and evaluate a compilation of variables that comprehensively capture the information contained in the summary of product characteristic (SmPC) and unequivocally describe the drug, its dosage options, and clinical pharmacokinetics. An expert panel defined and structured a set of variables and drafted a guideline to extract and enter information on dosage and clinical pharmacokinetics from textual SmPCs as published by the European Medicines Agency (EMA). The set of variables was iteratively revised and evaluated by data extraction and variable allocation of roughly 7% of all centrally approved drugs. The information contained in the SmPC was allocated to three information clusters consisting of 260 variables. The cluster "drug characterization" specifies the nature of the drug. The cluster "dosage" provides information on approved drug dosages and defines corresponding specific conditions. The cluster "clinical pharmacokinetics" includes pharmacokinetic parameters of relevance for dosing in clinical practice. A first evaluation demonstrated that, despite the complexity of the current free text SmPCs, dosage and pharmacokinetic information can be reliably extracted from the SmPCs and comprehensively described by a limited set of variables. By proposing a compilation of variables well describing drug dosage and clinical pharmacokinetics, the project represents a step forward towards the development of a comprehensive database system serving as information source for sophisticated CDSS.

  2. Medication errors in oral dosage form preparation for neonates: The importance of preparation technique.

    Science.gov (United States)

    Valizadeh, Sousan; Rasekhi, Mehri; Hamishehkar, Hamed; Asadollahi, Malihe; Hamishehkar, Hadi

    2015-01-01

    Considering the inability of neonates to swallow oral drugs in the form of solid tablets, the lack of appropriate dosage forms for infants, and the necessity to prepare some pills for neonates, the current study investigated dosage accuracy in drugs for neonates prepared from tablets by analyzing the concentrations of final products. Captopril and spironolactone, oral dosage forms that are not suitable for infants, were chosen as the drug model for this study. Demographic characteristics of nurses providing medications and tablet preparation methods were documented in a random observational method. To determine concentrations of final solutions, 120 drug samples (60 captopril and 60 spironolactone samples) prepared by Neonatal Intensive Care Unit nurses of the Children Cure and Health Hospital of Tabriz University of Medical Sciences were analyzed using high performance liquid chromatography (HPLC) and spectrophotometry. There was a significant error rate in the concentration of captopril in prepared solutions compared with the ordered dosage. No differences were observed in the demographic characteristics of the nurses and the method of preparation between the two drugs. The only difference related to the preparation technique was that in most cases (70.8%), one whole spironolactone tablet was used, whereas in around 50% of samples in captopril group, half or a quarter of one captopril tablet was utilized for the intended dosage (P = 0.009). This research suggests that the use of a whole tablet instead of a divided tablet in the manual preparation of medication dosage forms for neonates is the most appropriate approach.

  3. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.

    Science.gov (United States)

    Magtanong, Leslie; Ho, Cheuk Hei; Barker, Sarah L; Jiao, Wei; Baryshnikova, Anastasia; Bahr, Sondra; Smith, Andrew M; Heisler, Lawrence E; Choy, John S; Kuzmin, Elena; Andrusiak, Kerry; Kobylianski, Anna; Li, Zhijian; Costanzo, Michael; Basrai, Munira A; Giaever, Guri; Nislow, Corey; Andrews, Brenda; Boone, Charles

    2011-05-15

    Dosage suppression is a genetic interaction in which overproduction of one gene rescues a mutant phenotype of another gene. Although dosage suppression is known to map functional connections among genes, the extent to which it might illuminate global cellular functions is unclear. Here we analyze a network of interactions linking dosage suppressors to 437 essential genes in yeast. For 424 genes, we curated interactions from the literature. Analyses revealed that many dosage suppression interactions occur between functionally related genes and that the majority do not overlap with other types of genetic or physical interactions. To confirm the generality of these network properties, we experimentally identified dosage suppressors for 29 genes from pooled populations of temperature-sensitive mutant cells transformed with a high-copy molecular-barcoded open reading frame library, MoBY-ORF 2.0. We classified 87% of the 1,640 total interactions into four general types of suppression mechanisms, which provided insight into their relative frequencies. This work suggests that integrating the results of dosage suppression studies with other interaction networks could generate insights into the functional wiring diagram of a cell.

  4. The Caenorhabditis Elegans Gene Sdc-2 Controls Sex Determination and Dosage Compensation in Xx Animals

    Science.gov (United States)

    Nusbaum, C.; Meyer, B. J.

    1989-01-01

    We have identified a new X-linked gene, sdc-2, that controls the hermaphrodite (XX) modes of both sex determination and X chromosome dosage compensation in Caenorhabditis elegans. Mutations in sdc-2 cause phenotypes that appear to result from a shift of both the sex determination and dosage compensation processes in XX animals to the XO modes of expression. Twenty-eight independent sdc-2 mutations have no apparent effect in XO animals, but cause two distinct phenotypes in XX animals: masculinization, reflecting a defect in sex determination, and lethality or dumpiness, reflecting a disruption in dosage compensation. The dosage compensation defect can be demonstrated directly by showing that sdc-2 mutations cause elevated levels of several X-linked transcripts in XX but not XO animals. While the masculinization is blocked by mutations in sex determining genes required for male development (her-1 and fem-3), the lethality, dumpiness and overexpression of X-linked genes are not, indicating that the effect of sdc-2 mutations on sex determination and dosage compensation are ultimately implemented by two independent pathways. We propose a model in which sdc-2 is involved in the coordinate control of both sex determination and dosage compensation in XX animals and acts in the regulatory hierarchy at a step prior to the divergence of the two pathways. PMID:2759421

  5. Radiation dosage reduction in general dental practice using digital intraoral radiographic systems

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, Yoshihiko; Shibuya, Hiroshi; Kuroyanagi, Kinya [Tokyo Dental Coll., Chiba (Japan); Ota, Yoshiko

    1997-02-01

    This report describes the radiation dosage reduction possible in the general dental practice with two CCD (charge-coupled device)-based intraoral radiographic systems; the RVG-S (Trophy Radiologie, Vincennes, France) and the Sens-A-Ray (Regam Medical Systems, Sundsvall, Sweden). Radiation dosages (air-kerma; Gy) necessary for obtaining clinically acceptable images were measured at the cone tip using an ionization chamber type 660-1 (Nuclear Associates, Victoreen, Inc., Carle Place, New York, USA). When the RVG-S was used with an Oramatic 70 (Trophy Radiologie) X-ray generator, dosages at the cone tip ranged from 322 to 612 {mu}Gy. These corresponded to 40-60% of the dosages necessary when using Ektaspeed dental X-ray film (Eastman Kodak, Rochester, New York, USA) with a Heliodent 70 (Siemens, Erlangen, Germany) X-ray generator. At 60 kVp, the Sens-A-Ray reduced the dosage in the order of 30% compared with Ektaspeed dental X-ray film. Reduction in radiation dosage is one of the benefits of digital intraoral radiographic systems in general dental clinics. The RVG-S provides greater dose savings than does the Sens-A-Ray. (author)

  6. Efficiency of individual dosage of digoxin with calculated concentration

    Directory of Open Access Journals (Sweden)

    Zhao L

    2014-07-01

    digoxin and creatinine clearance, our results show that although there was a significant correlation between clearance of digoxin and creatinine clearance in the group overall, correlations were not evident within the different stages of renal function.Conclusion: The results of this study indicate that clearance of digoxin and the creatinine clearance rate cannot be explained by renal function alone and that the validity of the Konishi equation for individualizing the digoxin dosage in Chinese patients is limited, being applicable only in stage 3 renal disease. Further research in larger numbers of patients across all stages of renal function will be required in the future to verify the original Konishi model. Keywords: serum digoxin concentration, predicted concentration, renal insufficiency

  7. Jets and dijets in Au+Au and p+p collisions at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Hardtke, D.; STAR Collaboration

    2002-12-09

    Recent data from RHIC suggest novel nuclear effects in the production of high p{sub T} hadrons. We present results from the STAR detector on high p{sub T} angular correlations in Au+Au and p+p collisions at {radical}S = 200 GeV/c. These two-particle angular correlation measurements verify the presence of a partonic hard scattering and fragmentation component at high p{sub T} in both central and peripheral Au+Au collisions. When triggering on a leading hadron with p{sub T}>4 GeV, we observe a quantitative agreement between the jet cone properties in p+p and all centralities of Au+Au collisions. This quantitative agreement indicates that nearly all hadrons with p{sub T}>4 GeV/c come from jet fragmentation and that jet fragmentation properties are not substantially modified in Au+Au collisions. STAR has also measured the strength of back-to-back high p{sub T} charged hadron correlations, and observes a small suppression of the back-to-back correlation strength in peripheral collisions, and a nearly complete disappearance o f back-to-back correlations in central Au+Au events. These phenomena, together with the observed strong suppression of inclusive yields and large value of elliptic flow at high p{sub T}, are consistent with a model where high p{sub T} hadrons come from partons created near the surface of the collision region, and where partons that originate or propagate towards the center of the collision region are substantially slowed or completely absorbed.

  8. Equilibrium, kinetics and mechanism of Au3+, Pd2+and Ag+ions adsorption from aqueous solutions by graphene oxide functionalized persimmon tannin.

    Science.gov (United States)

    Wang, Zhongmin; Li, Xiaojuan; Liang, Haijun; Ning, Jingliang; Zhou, Zhide; Li, Guiyin

    2017-10-01

    In this study, a novel bio-adsorbent (PT-GO) was prepared by functionalization persimmon tannin (PT) with graphene oxide (GO) and the effective adsorption behaviors of Au 3+ , Pd 2+ and Ag + ions from aqueous solution was investigated. The PT-GO was characterized by Fourier transform infrared spectrometer (FTIR), scanning electronic microscope (SEM), thermogravimetric analysis (TGA) and Zeta potential. Many influence factors such as pH value, bio-adsorbent dosage, initial concentration of metal ions and contact time were optimized. The maximum adsorption capacity for Au 3+ , Pd 2+ and Ag + was 1325.09mg/g, 797.66mg/g and 421.01mg/g, respectively. The equilibrium isotherm for the adsorption of Au 3+ and Ag + on PT-GO were found to obey the Langmuir model, while the Freundlich model fitted better for Pd 2+ . The adsorption process of Au 3+ , Pd 2+ presented relatively fast adsorption kinetics with pseudo-second-order equation as the best fitting model, while the pseudo-first-order kinetic model was suitable for describing the adsorption of Ag + . Combination of ion exchange, electrostatic interaction and physical adsorption was the mechanism for adsorption of Au 3+ , Pd 2+ and Ag + onto PT-GO bio-adsorbent. Therefore, the PT-GO bio-adsorbent would be an ideal adsorbent for removal of precious metal ions and broaden the potential applications of persimmon tannin in environmental research. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Engagement militant et politisation des mobilisations au sein des oppositions urbaines à Istanbul

    Directory of Open Access Journals (Sweden)

    Clémence Petit

    2011-07-01

    Full Text Available La Municipalité du Grand Istanbul met en œuvre depuis quelques années une « politique de transformation urbaine » pour faire d’Istanbul une ville moderne et compétitive sur la scène mondiale. Les mobilisations locales et les mouvements protestataires se multiplient pour infléchir une politique qui domine aujourd’hui l’agenda urbain « néolibéral » et empêcher les démolitions et déplacements de population escomptés. Au-delà de la distance au politique généralement affichée – condition de légitimité dans le système sécuritaire mis en place en Turquie après le coup d’État de 1980 – ces « oppositions urbaines » sont traversées par des débats sur la place du politique dans la mobilisation. À partir de l’étude sociologique de deux associations de quartiers et de deux mouvements de « professionnels urbains », cette contribution analyse le travail de définition des cadrages et répertoires d’action propres à chaque mouvement. Elle fait apparaître le rôle de ces professionnels urbains dans la requalification politique du désaccord qui divise les oppositions urbaines entre une stratégie « experte » et une stratégie plus politique. L’analyse met néanmoins en évidence le caractère dynamique et relatif – en termes de contextes et d’échelles – des stratégies d’appropriation des politiques publiques locales et des processus de politisation des « mouvements urbains ».The Istanbul Greater Municipality has been implementing for a few years numerous ‘urban renewal projects’ to change Istanbul into a modern and competitive city on the global scene. Reacting to the demolitions and evictions of entire neighbourhoods caused by these projects, some inhabitants and ‘urban professionals’ mobilize within new movements and neighbourdhood associations. Beyond the distance they usually show towards politics – a condition of legitimacy in the securitarian system introduced in

  10. Prises de risques chez les jeunes de Bobo Dioulasso: une analyse des facteurs associés à la précocité et au multipartenariat sexuel

    Science.gov (United States)

    Adohinzin, Clétus Come; Meda, Nicolas; Belem, Adrien Marie Gaston; Ouédraogo, Georges Anicet; Sombie, Issiaka; Berthe, Abdramane; Fond-Harmant, Laurence

    2016-01-01

    Introduction Malgré les efforts d'éducation à la santé, les jeunes continuent d'adopter des comportements sexuels à risques, susceptibles d'avoir des répercussions importantes sur leur santé. Cette étude visait à analyser les facteurs associés à la précocité sexuelle et au multipartenariat chez les jeunes de 19-24 ans de Bobo-Dioulasso. Méthodes Il s'agit d'une étude quantitative et transversale. Les données d'enquête ont été recueillies en décembre 2014 à Bobo-Dioulasso (Burkina Faso), auprès de 573 jeunes de 15 à 24 ans. Ces enquêtés ont été sélectionnés par un sondage en grappes à deux degrés. Des facteurs à risques relatifs à la précocité sexuelle et au multipartenariat ont été analysés à l'aide du logiciel Stata IC 13. Le seuil de signification de Pdes enquêtés (54%) étaient sexuellement actifs dont 14% avant l'âge de 16 ans. Le multipartenariat sexuel avait été observé chez 24% des jeunes sexuellement actifs. Parmi les facteurs déterminants de la précocité sexuelle et du multipartenariat figuraient l'âge, le sexe, le niveau d'étude, et la situation économique des parents. Nos données avaient aussi montré que les rapports sexuels trop précoces étaient associés au multipartenariat sexuel (pdes jeunes à retarder les premiers rapports sexuels et à mieux évaluer les risques seront de toute importance. Les capacités des parents, des enseignants et des prestataires devraient être aussi renforcées pour l'amélioration de la qualité des relations entre eux et les jeunes. PMID:28292094

  11. Rapidity density distributions in Au+Au and Au+Ag interactions at 11.6 A GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Nystrand, J.I. [Div. of Cosmic and Subatomic Physis, Lund Univ. (Sweden); Adamovich, M.I.; Aggarwal, M.M.; Alexandrov, Y.A.; Andreeva, N.P.; Anzon, Z.V.; Arora, R.; Avetyan, F.A.; Badyal, S.K.; Basova, E.; Bazarov, I.K.; Bhalla, K.B.; Bhasin, A.; Bhatia, V.S.; Bogdanov, V.G.; Bubnov, V.I.; Burnett, T.H.; Cai, X.; Carshiev, D.A.; Ceitimbetov, A.M.; Chasnikov, I.Y.; Chernova, L.P.; Chernyavsky, M.M.; Eligbaeva, G.Z.; Eremenko, L.E.; Gaitinov, A.S.; Ganssauge, E.R.; Garpman, S.; Gerassimov, S.G.; Graf, C.; Grote, J.; Gulamov, K.G.; Gupta, S.K.; Gupta, V.K.; Jakobsson, B.; Just, L.; Kachroo, S.; Kalyachkina, G.S.; Kanygina, E.K.; Karabova, M.; Kharlamov, S.P.; Kitroo, S.; Krasnov, S.A.; Kumar, V.; Larionova, V.G.; Li, Y.D.; Liu, L.S.; Lokanatan, S.; Lord, J.J.; Lukicheva, N.S.; Luo, S.B.; Maksimkina, T.N.; Mangotra, L.K.; Marutyan, N.A.; Maslennikova, N.V.; Mittra, I.S.; Mookerjee, S.; Musulmanbekov, J.J.; Nasyrov, S.Z.; Navotny, V.S.; Ochs, M.; Orlova, G.I.; Otterlund, I.; Peresadko, N.G.; Petrov, N.V.; Plyushchev, V.A.; Qian, W.Y.; Qin, Y.M.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Roeper, M.; Saidkhanov, N.; Salmanova, N.A.; Sarkisova, L.G.; Sarkisyan, V.R.; Shabratova, G.S.; Shakhova, T.I.; Shpilev, S.N.; Skelding, D.; Soederstrom, K.; Solovjeva, Z.I.; Stenlund, E; Surin, E.L.; Svechnikova, L.N.; Tolstov, K.D.; Tothova, M.; Tretyakova, M.I.; Trofimova, T.P.; Tuleeva, U.; Tursunov, B.P.; Vokal, S.; Vrlakova, J.; Wang, H.Q.; Weng, Z.Q.; Wilkes, R.J.; Xia, Y.L.; Yang, C.B.; Zhang, D.H.; Zheng, P.Y.; Zhokhova, S.I.; Zhou, D.C.; EMU01 Collaboration

    1994-01-03

    Pseudorapidity density distributions of charged particles in heavy-ion collisions have been studied. The results from EMU01 have been compared to the results from the experiments WA80 and E802. The recently obtained pseudorapidity distributions from Au+Au and Au+Ag interactions have been compared to a linear extrapolation from lighter systems. (orig.)

  12. Synthesis and characterization in AuCu–Si nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Novelo, T.E., E-mail: tenovelo@hotmail.com [Centro de Investigación en Materiales Avanzados, S.C., Laboratorio Nacional de Nanotecnología, Av. Miguel de Cervantes 120, Complejo Industrial Chihuahua, 31109 Chihuahua, Chihuahua Mexico (Mexico); Amézaga-Madrid, P. [Centro de Investigación en Materiales Avanzados, S.C., Laboratorio Nacional de Nanotecnología, Av. Miguel de Cervantes 120, Complejo Industrial Chihuahua, 31109 Chihuahua, Chihuahua Mexico (Mexico); Maldonado, R.D. [Universidad Anáhuac-Mayab, Carretera Mérida-Progreso Km. 15.5 A.P. 96-Cordemex, CP. 97310 Mérida, Yucatán Mexico (Mexico); Oliva, A.I. [Centro de Investigación y de Estudios Avanzados el IPN Unidad Mérida, Departamento de Física Aplicada, Km 6 Antigua Carretera a Progreso, A.P. 73-Cordemex, 97310 Mérida, Yucatán Mexico (Mexico); Alonzo-Medina, G.M. [Universidad Anáhuac-Mayab, Carretera Mérida-Progreso Km. 15.5 A.P. 96-Cordemex, CP. 97310 Mérida, Yucatán Mexico (Mexico)

    2015-03-15

    Au/Cu bilayers with different Au:Cu concentrations (25:75, 50:50 and 75:25 at.%) were deposited on Si(100) substrates by thermal evaporation. The thicknesses of all Au/Cu bilayers were 150 nm. The alloys were prepared by thermal diffusion into a vacuum oven with argon atmosphere at 690 K during 1 h. X-ray diffraction analysis revealed different phases of AuCu and CuSi alloys in the samples after annealing process. CuSi alloys were mainly obtained for 25:75 at.% samples, meanwhile the AuCuII phase dominates for samples prepared with 50:50 at.%. Additionally, the Au:Cu alloys with 75:25 at.%, produce Au{sub 2}Cu{sub 3} and Au{sub 3}Cu phases. The formed alloys were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS) to study the morphology and the elemental concentration of the formed alloys. - Highlights: • AuCu/Si alloy thin films were prepared by thermal diffusion. • Alloys prepared with 50 at.% of Au produce the AuCuII phase. • Alloys prepared with 75 at.% of Au produce Au{sub 3}Cu and Au{sub 2}Cu{sub 3} phases. • All alloys present diffusion of Si and Cu through the CuSi alloy formation.

  13. Frequency of dosage prescribing medication errors associated with manual prescriptions for very preterm infants.

    Science.gov (United States)

    Horri, J; Cransac, A; Quantin, C; Abrahamowicz, M; Ferdynus, C; Sgro, C; Robillard, P-Y; Iacobelli, S; Gouyon, J-B

    2014-12-01

    The risk of dosage Prescription Medication Error (PME) among manually written prescriptions within 'mixed' prescribing system (computerized physician order entry (CPOE) + manual prescriptions) has not been previously assessed in neonatology. This study aimed to evaluate the rate of dosage PME related to manual prescriptions in the high-risk population of very preterm infants (GA prescription system. The study was based on a retrospective review of a random sample of manual daily prescriptions in two neonatal intensive care units (NICU) A and B, located in different French University hospitals (Dijon and La Reunion island). Daily prescription was defined as the set of all drugs manually prescribed on a single day for one patient. Dosage error was defined as a deviation of at least ±10% from the weight-appropriate recommended dose. The analyses were based on the assessment of 676 manually prescribed drugs from NICU A (58 different drugs from 93 newborns and 240 daily prescriptions) and 354 manually prescribed drugs from NICU B (73 different drugs from 131 newborns and 241 daily prescriptions). The dosage error rate per 100 manually prescribed drugs was similar in both NICU: 3·8% (95% CI: 2·5-5·6%) in NICU A and 3·1% (95% CI: 1·6-5·5%) in NICU B (P = 0·54). Among all the 37 identified dosage errors, the over-dosing was almost as frequent as the under-dosing (17 and 20 errors, respectively). Potentially severe dosage errors occurred in a total of seven drug prescriptions. None of the dosage PME was recorded in the corresponding medical files and information on clinical outcome was not sufficient to identify clinical conditions related to dosage PME. Overall, 46·8% of manually prescribed drugs were off label or unlicensed, with no significant differences between prescriptions with or without dosage error. The risk of a dosage PME increased significantly if the drug was included in the CPOE system but was manually prescribed (OR = 3·3; 95% CI: 1·6-7·0

  14. Au nanoparticles films used in biological sensing

    Energy Technology Data Exchange (ETDEWEB)

    Rosales Perez, M; Delgado Macuil, R; Rojas Lopez, M; Gayou, V L [Centro de Investigacion en BiotecnologIa Aplicada del IPN, Tepetitla Tlaxcala Mexico C.P. 90700 (Mexico); Sanchez Ramirez, J F, E-mail: mrosalespe@ipn.m [CICATA Legaria Instituto Politecnico Nacional, Mexico Distrito Federal (Mexico)

    2009-05-01

    Lactobacillus para paracasei are used commonly as functional food and probiotic substances. In this work Au nanoparticles self-assembled films were used for Lactobacillus para paracasei determination at five different concentrations. Functionalized substrates were immersed in a colloidal solution for one and a half hour at room temperature and dried at room temperature during four hours. After that, drops of Lactobacillus para paracasei in aqueous solution were put into the Au nanoparticles film and let dry at room temperature for another two hours. Infrared spectroscopy in attenuated total reflectance sampling mode was used to observe generation peaks due to substrate silanization, enhancement of Si-O band intensity due to the Au colloids added to silanized substrate and also to observe the enhancement of Lactobacillus para paracasei infrared intensity of the characteristic frequencies at 1650, 1534 and 1450 cm{sup -1} due to surface enhancement infrared absorption.

  15. PHENIX Results in d + Au Collisions

    Science.gov (United States)

    Chen, Chin-Hao

    2016-04-01

    The PHENIX experiment at the Relativistic Heavy Ion Collider has performed a comprehensive set of measurements in d + Au collisions. Observables in d + Au collisions were originally conceived as a control experiment where no quark-gluon plasma is formed and one could isolate so-called cold nuclear matter effects, including nuclear modified parton distributions and parton multiple scattering. However, recent data from the PHENIX experiment in d + Au, in conjunction with new p + Pb results at the Large Hadron Collider, give strong evidence for a very different picture. We present new results that hint at the formation of a small quark-gluon plasma, that though short lived, leaves a fingerprint of evidence on final state observables. These new results will be discussed in the context of competing theoretical interpretations.

  16. Total structure determination of thiolate-protected Au38 nanoparticles.

    Science.gov (United States)

    Qian, Huifeng; Eckenhoff, William T; Zhu, Yan; Pintauer, Tomislav; Jin, Rongchao

    2010-06-23

    We report the total structure of Au(38)(SC(2)H(4)Ph)(24) nanoparticles determined by single crystal X-ray crystallography. This nanoparticle is based upon a face-fused Au(23) biicosahedral core, which is further capped by three monomeric Au(SR)(2) staples at the waist of the Au(23) rod and six dimeric staples with three on the top icosahedron and other three on the bottom icosahedron. The six Au(2)(SR)(3) staples are arranged in a staggered configuration, and the Au(38)S(24) framework has a C(3) rotation axis.

  17. Semi-solid dosage form of clonazepam for rapid oral mucosal absorption.

    Science.gov (United States)

    Sakata, Osamu; Machida, Yoshiharu; Onishi, Hiraku

    2011-07-01

    In order to obtain an alternative to the intravenous (i.v.) dosage form of clonazepam (CZ), an oral droplet formulation of CZ was developed previously; however, the droplet was physically unstable. Therefore, in the present study, it was attempted to develop an easily-handled dosage form, which was more physically stable and allowed rapid drug absorption from oral mucosa. A semi-solid dosage form, composed of polyethylene glycol 1500 (PEG), CZ, and oleic acid (OA) at 37/1/2 (w/w) and named PEG/CZ/OA, and a semi-solid dosage form containing PEG and CZ at 39/1 (w/w), called PEG/CZ, were prepared. Their physical stability in air at room temperature and oral mucosal absorption in rats were investigated. The semi-solid dosage forms were much more stable physically than the droplet, that is, no recrystallization of CZ was observed for at least 8 days. The effective concentration for humans and rats (20 ng/mL or more) was achieved within 30 min after buccal administration for both PEG/CZ/OA and PEG/CZ. The plasma concentration increased gradually and less varied at each time point for PEG/CZ/OA. PEG/CZ/OA was found to show more rapid and higher absorption of CZ in buccal administration than in sublingual administration. Buccal administration with the semi-solid dosage PEG/CZ with or without OA was suggested to be a possibly useful novel dosage form as an alternative to i.v. injection.

  18. Au nanorice assemble electrolytically into mesostars.

    Science.gov (United States)

    Bardhan, Rizia; Neumann, Oara; Mirin, Nikolay; Wang, Hui; Halas, Naomi J

    2009-02-24

    Star-shaped mesotructures are formed when an aqueous suspension of Au nanorice particles, which consist of prolate hematite cores and a thin Au shell, is subjected to an electric current. The nanorice particles assemble to form hyperbranched micrometer-scale mesostars. To our knowledge, this is the first reported observation of nanoparticle assembly into larger ordered structures under the influence of an electrochemical process (H(2)O electrolysis). The assembly is accompanied by significant modifications in the morphology, dimensions, chemical composition, crystallographic structure, and optical properties of the constituent nanoparticles.

  19. On the Stark broadening in the Au I and Au II spectra from a helium plasma

    Science.gov (United States)

    Djeniže, S.

    2009-03-01

    The Stark FWHM (Full-Width at Half of the Maximal line intensity, W) of 5 neutral and 26 singly ionized gold (Au I and Au II, respectively) spectral lines have been measured in laboratory helium plasma at approximately 16,600 K electron temperature and 7.4 × 10 22 m - 3 electron density. Five Au I and ten Au II W values are reported for the first time. The Au II W values are compared with recent theoretical data, calculated based on a modified semi-empirical approach, and also with existing experimental W values. Our normalized Stark widths are six times higher than those measured in a laser-produced plasma. Possible explanation of this is recommended here. An agreement (within the accuracy of the experiment and uncertainties of the theoretical approach used) with the recently calculated W data was found in the 6p-7s Au II transition. The calculated hyperfine splitting for the five Au II lines in the 6s-6p transition is also presented. At the stated helium plasma conditions, Stark broadening has been found to be the dominant mechanism in the Au I and Au II line shape formation. A modified version of the linear low-pressure pulsed arc was used as a plasma source operated in helium, with gold atoms as impurities evaporated from the thin gold cylindrical plates located in the homogeneous part of the discharge, providing conditions free of self-absorption. This plasma source ensures good conditions for generation of excited gold ions due to Penning and charge exchange effects.

  20. A novel Au SINE sequence found in a gymnosperm.

    Science.gov (United States)

    Yagi, Eiki; Akita, Toru; Kawahara, Taihachi

    2011-01-01

    Although many SINE families have been identified in the animal kingdom, only a few SINE families have been identified in plants, and their distribution is somewhat limited. The Au SINE (Au) has been found discontinuously in basal angiosperms, monocots, and eudicots. In this study, we examined the presence of the Au in gymnosperms and ferns by PCR using internal primers for Au. As a result, we found Au in a gymnosperm species, Ephedra ciliata. Therefore, Au was supposed to be present in the common ancestor of angiosperms and gymnosperms. The Au in E. ciliate was 15 bp shorter than the consensus sequence, which is similar to the Au SINE found in Glycine. However, the 3'end of the Au found in E. ciliate was more similar to the 3'end of the Medicago-type Au than that of the Glycine-type Au. A phylogenetic tree indicated that the Au sequence from E. ciliate is more closely related to the sequence found in Glycine than that found in Medicago/Lotus. These results indicated that Au were present in both angiosperms and gymnosperms.

  1. A Detailed Exploration Into the Association of Prescribed Opioid Dosage and Overdose Deaths Among Patients With Chronic Pain.

    Science.gov (United States)

    Bohnert, Amy S B; Logan, Joseph E; Ganoczy, Dara; Dowell, Deborah

    2016-05-01

    High opioid dosage has been associated with overdose, and clinical guidelines have cautioned against escalating dosages above 100 morphine-equivalent mg (MEM) based on the potential harm and the absence of evidence of benefit from high dosages. However, this 100 MEM threshold was chosen somewhat arbitrarily. To examine the association of prescribed opioid dosage as a continuous measure in relation to risk of unintentional opioid overdose to identify the range of dosages associated with risk of overdose at a detailed level. In this nested case-control study with risk-set sampling of controls, cases (opioid overdose decedents) and controls were identified from a population of patients of the Veterans Health Administration who were prescribed opioids and who have a chronic pain diagnosis. Unintentional fatal opioid analgesic overdose was measured from National Death Index records and prescribed opioid dosage from pharmacy records. The average prescribed opioid dosage was higher (Popioid overdose death, indicating that, on average, overdose cases had a prescribed opioid dosage higher than 71% of controls. A clear cut-point in opioid dosage to distinguish between overdose cases and controls was not found. However, lowering the recommended dosage threshold below the 100 MEM used in many recent guidelines would affect proportionately few patients not at risk for overdose while potentially benefitting many of those at risk for overdose.

  2. Charged hadron transverse momentum distributions in Au+Au collisions at {radical}S{sub NN} = 200 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Back, B.B.; Baker, M.D.; Barton, D.S.; Betts, R.R.; Ballintijn, M.; Bickley, A.A.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Decowski, M.P.; Garcia, E.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Heintzelman, G.A.; Henderson, C.; Hofman, D.J.; Hollis, R.S.; Holynski, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J.L.; Katzy, J.; Khan, N.; Kucewicz, W.; Kulinich, P.; Kuo, C.M.; Lin, W.T.; Manly, S.; McLeod, D.; Michalowski, J.; Mignerey, A.C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I.C.; Pernegger, H.; Reed, C.; Remsberg, L.P.; Reuter, M.; Roland, C.; Roland, G.; Rosenberg, L.; Sagerer, J.; Sarin, P.; Sawicki, P.; Skulski, W.; Steadman, S.G.; Steinberg, P.; Stephans, G.S.F.; Stodulski, M.; Sukhanov, A.; Tang, J.-L.; Teng, R.; Trzupek, A.; Vale, C.; Nieuwenhuizen, G.J. van; Verdier, R.; Wadsworth, B.; Wolfs, F.L.H.; Wosiek, B.; Wozniak, K.; Wuosmaa, A.H.; Wyslouch, B

    2003-04-01

    We present transverse momentum distributions of charged hadrons produced in Au+Au collisions at {radical}S{sub NN} = 200 GeV. The evolution of the spectra for transverse momenta p{sub T} from 0.25 to 5 GeV/C is studied as a function of collision centrality. We find a significant change of the spectral shape between proton-antiproton and peripheral Au+Au collisions. When comparing peripheral to central Au+Au collisions, we find that the yields at the highest p{sub T} exhibit approximate scaling with the number of participating nucleons, rather than scaling with the number of binary collisions.

  3. Manufacturing Solid Dosage Forms from Bulk Liquids Using the Fluid-bed Drying Technology.

    Science.gov (United States)

    Qi, Jianping; Lu, Y I; Wu, Wei

    2015-01-01

    Solid dosage forms are better than liquid dosage forms in many ways, such as improved physical and chemical stability, ease of storage and transportation, improved handling properties, and patient compliance. Therefore, it is required to transform dosage forms of liquid origins into solid dosage forms. The functional approaches are to absorb the liquids by solid excipients or through drying. The conventional drying technologies for this purpose include drying by heating, vacuum-, freeze- and spray-drying, etc. Among these drying technologies, fluidbed drying emerges as a new technology that possesses unique advantages. Fluid-bed drying or coating is highly efficient in solvent removal, can be performed at relatively low temperatures, and is a one-step process to manufacture formulations in pellet forms. In this article, the status of the art of manufacturing solid dosage forms from bulk liquids by fluid-bed drying technology was reviewed emphasizing on its application in solid dispersion, inclusion complexes, self-microemulsifying systems, and various nanoscale drug delivery systems.

  4. Dependence of surface smoothing, sputtering and etching phenomena on cluster ion dosage

    CERN Document Server

    Song, J H; Choi, W K

    2002-01-01

    The dependence of surface smoothing and sputtering phenomena of Si (1 0 0) solid surfaces irradiated by CO sub 2 cluster ions on cluster-ion dosage was investigated using an atomic force microscope. The flux and total ion dosage of impinging cluster ions at the acceleration voltage of 50 kV were fixed at 10 sup 9 ions/cm sup 2 s and were scanned from 5x10 sup 1 sup 0 to 5x10 sup 1 sup 3 ions/cm sup 2 , respectively. The density of hillocks induced by cluster ion impact was gradually increased with the dosage up to 5x10 sup 1 sup 1 ions/cm sup 2 , which caused that the irradiated surface became rough from 0.4 to 1.24 nm in root-mean-square roughness (sigma sub r sub m sub s). At the boundary of the ion dosage of 10 sup 1 sup 2 ions/cm sup 2 , the density of the induced hillocks was decreased and sigma sub r sub m sub s was about 1.21 nm, not being deteriorated further. At the dosage of 5x10 sup 1 sup 3 ions/cm sup 2 , the induced hillocks completely disappeared and the surface became very flat as much as sigma...

  5. Effects of pharmaceutical processing on pepsin activity during the formulation of solid dosage forms.

    Science.gov (United States)

    Kristó, Katalin; Pintye-Hódi, Klára

    2013-02-01

    The main aim of this study was to investigate the effects of pharmaceutical technological methods on pepsin activity during the formulation of solid dosage forms. The circumstances of direct compression and wet granulation were modeled. During direct compression, the heat and the compression force must be taken into consideration. The effects of these parameters were investigated in three materials (pure pepsin, and 1:1 (w/w) pepsin-tartaric acid and 1:1 (w/w) pepsin-citric acid powder mixtures). It was concluded that direct compression is appropriate for the formulation of solid dosage forms containing pepsin through application without acids or with acids at low compression force. The effects of wet granulation were investigated with a factorial design for the same three materials. The factors were time, temperature and moisture content. There was no significant effect of the factors when acids were not applied. Temperature was a significant factor when acids were applied. The negative effect was significantly higher for citric acid than for tartaric acid. It was found that wet granulation can be utilized for the processing of pepsin into solid dosage forms under well-controlled circumstances. The application of citric acid is not recommended during the formulation of solid dosage forms through wet granulation. A mathematically based optimization may be necessary for preformulation studies of the preparation of dosage forms containing sensitive enzymes.

  6. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia.

    Science.gov (United States)

    Poirier, Valerie J; Burgess, Kristine E; Adams, William M; Vail, David M

    2004-01-01

    The purpose of this study was to evaluate short-term adverse effects and determine a safe dosage for vinorelbine (Navelbine)--a new semisynthetic vinca alkaloid--in dogs with malignant tumors. Nineteen dogs were treated with vinorelbine as a 5-minute IV infusion every 7 days at starting dosages ranging from 10 to 20 mg/m2. The median number of treatments per dog was 7 (range, 1-11). The maximum tolerated dosage varied between 15 and 18 mg/m2, and a starting dosage of 15 mg/m2 is recommended. Neutropenia was the dose-limiting toxicity. Although efficacy was a secondary endpoint of this dosage-finding study, 2 dogs with metastatic bronchoalveolar carcinoma experienced a partial response for an overall response rate of 12.5% in 16 dogs with gross measurable disease. Three dogs with microscopic disease were treated (incompletely excised bronchoalveolar carcinoma or lymph node metastatic disease). Two died of pulmonary metastatic disease 113 and 196 days posttreatment, and 1 is still alive after at least 730 days. The well-tolerated toxicity profile and clinical activity observed in dogs with bronchoalveolar carcinoma warrants further investigation.

  7. Hyperintense acute reperfusion marker is associated with higher contrast agent dosage in acute ischaemic stroke

    Energy Technology Data Exchange (ETDEWEB)

    Ostwaldt, Ann-Christin; Schaefer, Tabea; Villringer, Kersten; Fiebach, Jochen B. [Charite Universitaetsmedizin Berlin, Academic Neuroradiology, Center for Stroke Research Berlin (CSB), Berlin (Germany); Rozanski, Michal; Ebinger, Martin [Charite Universitaetsmedizin Berlin, Academic Neuroradiology, Center for Stroke Research Berlin (CSB), Berlin (Germany); Charite Universitaetsmedizin, Department of Neurology, Berlin (Germany); Jungehuelsing, Gerhard J. [Stiftung des Buergerlichen Rechts, Juedisches Krankenhaus Berlin, Berlin (Germany)

    2015-11-15

    The hyperintense acute reperfusion marker (HARM) on fluid-attenuated inversion recovery (FLAIR) images is associated with blood-brain barrier (BBB) permeability changes. The aim of this study was to examine the influence of contrast agent dosage on HARM incidence in acute ischaemic stroke patients. We prospectively included 529 acute ischaemic stroke patients (204 females, median age 71 years). Patients underwent a first stroke-MRI within 24 hours from symptom onset and had a follow-up on day 2. The contrast agent Gadobutrol was administered to the patients for perfusion imaging or MR angiography. The total dosage was calculated as ml/kg body weight and ranged between 0.04 and 0.31 mmol/kg on the first examination. The incidence of HARM was evaluated on day 2 FLAIR images. HARM was detected in 97 patients (18.3 %). HARM incidence increased significantly with increasing dosages of Gadobutrol. Also, HARM positive patients were significantly older. HARM was not an independent predictor of worse clinical outcome, and we did not find an association with increase risk of haemorrhagic transformation. A higher dosage of Gadobutrol in acute stroke patients on initial MRI is associated with increased HARM incidence on follow-up. MRI studies on BBB should therefore standardize contrast agent dosages. (orig.)

  8. Adrenal Insufficiency under Standard Dosage of Glucocorticoid Replacement after Unilateral Adrenalectomy for Cushing’s Syndrome

    Directory of Open Access Journals (Sweden)

    Kentaro Fujii

    2016-01-01

    Full Text Available Glucocorticoid replacement is needed for patients after adrenal surgery for Cushing’s syndrome; however, the adequate dosage is not easily determined. The patient was a 62-year-old woman who has had hypertension for 5 years and presented with heart failure due to hypertrophic cardiomyopathy. She consulted with us because of general fatigue, facial edema, and muscle weakness and was diagnosed with Cushing’s syndrome. A laparoscopic left adrenalectomy was performed, standard dosage of postoperative replacement was administered, and she was discharged with 30 mg/day of hydrocortisone (cortisol. However, she suffered from loss of appetite and was transferred to an emergency unit with the symptoms of adrenal insufficiency on postoperative day 15. After initial hydrocortisone replacement with 200 mg/day, the dosage was gradually decreased during hospitalization; however, reduction of hydrocortisone dosage lower than 60 mg/day was difficult because of nausea and fatigue. Her circadian cortisol profile after hydrocortisone administration showed delayed and lowered peaks, which suggested that hydrocortisone absorption in the intestine was impaired. Therefore, complicated heart failure may have led to the adrenal insufficiency in the patient. In such cases, we should consider postoperative administration of more than the standard dosage of hydrocortisone to avoid adrenal insufficiency after surgery for Cushing’s syndrome.

  9. Amodiaquine Dosage and Tolerability for Intermittent Preventive Treatment To Prevent Malaria in Children ▿ †

    Science.gov (United States)

    Cairns, M.; Cisse, B.; Sokhna, C.; Cames, C.; Simondon, K.; Ba, E. H.; Trape, J.-F.; Gaye, O.; Greenwood, B. M.; Milligan, P. J. M.

    2010-01-01

    Sulfadoxine-pyrimethamine with amodiaquine (SP-AQ) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children (IPTc), but the amodiaquine component is not always well tolerated. We determined the association between amodiaquine dosage by body weight and mild adverse events (AEs) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of IPTc in Senegal, one in which AQ dose was determined by age and the other in which it was determined by weight category. Both dosage strategies resulted in some children receiving AQ doses above the recommended therapeutic range. The odds of vomiting increased with increasing amodiaquine dosage. In one study, incidence of fever also increased with increasing dosage. Anthropometric data from 1,956 children were used to predict the dosing accuracy of existing and optimal alternative regimens. Logistic regression models describing the probability of AEs by dosage were used to predict the potential reductions in mild AEs for each regimen. Simple amendments to current AQ dosing schedules based on the child's age could substantially increase dosing accuracy and thus improve the tolerability of IPTc using SP-amodiaquine in situations where weighing the child is impractical. PMID:20065053

  10. Patrimoine culinaire thaïlandais au coeur de Paris

    OpenAIRE

    Deslis, Jirasri; PIPATPALLOP, Porntip; de Pablo, Elisabeth; Stockinger, Peter; LEGRAND, Valérie

    2009-01-01

    Dans le cadre d'une étude consacrée à la spécificité culturelle de la communauté thaïe à Paris et en Ile-de-France, nous vous présentons un premier reportage consacré à la très réputée cuisine thaïe.Grâce à Jirasri Deslis, Portnip Pipatpallop et son restaurant "Im Thaï Gourmet", nous a aimablement ouvert ses portes afin de nous expliquer quelques aspects pratiques et techniques relatifs à la tradition culinaire de Thaïlande.Porntip PIPATPALLOP concrétise la passion pour la cuisine de son pays...

  11. La cardiomyopathie dilatee au centre hospitalier Universitaire ...

    African Journals Online (AJOL)

    La cardiomyopathie dilatee au centre hospitalier Universitaire Tokoin de Lome : A propos de 74 cas hospitalises. ... Le traitement médical a fait appel aux diurétiques (85,1%), aux inhibiteurs de l'enzyme de conversion de l'angiotensine (83,8%) et aux digitaliques (55,4%). Des antiarythmiques, des antiaggrégants ...

  12. Nanoporous Au: an unsupported pure gold catalyst?

    Energy Technology Data Exchange (ETDEWEB)

    Wittstock, A; Neumann, B; Schaefer, A; Dumbuya, K; Kuebel, C; Biener, M; Zielasek, V; Steinrueck, H; Gottfried, M; Biener, J; Hamza, A; B?umer, M

    2008-09-04

    The unique properties of gold especially in low temperature CO oxidation have been ascribed to a combination of various effects. In particular, particle sizes below a few nm and specific particle-support interactions have been shown to play important roles. On the contrary, recent reports revealed that monolithic nanoporous gold (npAu) prepared by leaching a less noble metal, such as Ag, out of the corresponding alloy can also exhibit remarkably high catalytic activity for CO oxidation, even though no support is present. Therefore, it was claimed to be a pure and unsupported gold catalyst. We investigated npAu with respect to its morphology, surface composition and catalytic properties. In particular, we studied the reaction kinetics for low temperature CO oxidation in detail taking mass transport limitation due to the porous structure of the material into account. Our results reveal that Ag, even if removed almost completely from the bulk, segregates to the surface resulting in surface concentrations of up to 10 at%. Our data suggest that this Ag plays a significant role in activation of molecular oxygen. Therefore, npAu should be considered as a bimetallic catalyst rather than a pure Au catalyst.

  13. Anomalies hematologiques au cours des accidents vasculaires ...

    African Journals Online (AJOL)

    Anomalies hematologiques au cours des accidents vasculaires cerebraux a Abidjan des (Cote d'Ivoire) ... Introduction: En Côte d'Ivoire, les accidents vasculaires cérébraux (AVC) sont de plus en ... The objective of the study was to report the hematological abnormalities in the stroke among black African patients in Abidjan.

  14. Didaktik des außerschulischen Lernens

    CERN Document Server

    Sauerborn, Petra

    2012-01-01

    Kernprobleme schulischer Bildung sind die zunehmenden Verluste an Realitäts- und Praxisbezug sowie die einseitige Betonung der fachwissenschaftlichen Kenntnisse. In jüngster Zeit werden insbesondere moderne didaktisch-methodische Konzepte näher diskutiert und praktiziert. So finden sich etwa die Stichwörter Handlungsorientierter Unterricht und Offener Unterricht in der fachdidaktischen Diskussion wieder. Eine wesentlich aktuellere Form stellt das außerschulische Lernen dar. Ein modernes pädagogisches Verständnis sieht den Unterricht heute nicht mehr als ausschließliche Tätigkeit des Lehrers an, sondern als Aktivität der Lernenden. Außerschulisches Lernen beschreibt die originale Begegnung im Unterricht außerhalb des Klassenzimmers. An außerschulischen Lernorten findet eine unmittelbare AuseinanderSetzung des Lernenden mit seiner räumlichen Umgebung statt. Charakteristisch sind hierbei vor allem die aktive(Mit-)Gestaltung sowie die eigenständige Wahrnehmung mehrperspektivischer Bildungsinhalte d...

  15. Melamine structures on the Au(111) surface

    NARCIS (Netherlands)

    Silly, Fabien; Shaw, Adam Q.; Castell, Martin R.; Briggs, G. A. D.; Mura, Manuela; Martsinovich, Natalia; Kantorovich, Lev

    2008-01-01

    We report on a joint experimental and theoretical study of the ordered structures of melamine molecules formed on the Au(111)-(22 x root 3) surface. Scanning tunneling microscopy (STM) images taken under UHV conditions reveal two distinct monolayers one of which has never been reported before on

  16. Surface structure of AU3Cu(001)

    DEFF Research Database (Denmark)

    Eckstein, G.A.; Maupai, S.; Dakkouri, A.S.

    1999-01-01

    The surface morphology, composition, and structure of Au3Cu(001) as determined by scanning tunneling microscopy and surface x-ray diffraction are presented. Atomic resolution STM images reveal distinctive geometric features. The analysis of the surface x-ray diffraction data provides clear evidence...... for the surface structure. [S0163-1829(99)04535-X]....

  17. Le CRDI au Pérou

    International Development Research Centre (IDRC) Digital Library (Canada)

    Arequipa. Trujillo. Chiclayo. Piura. Cuzco. Pucallpa. Iquitos. 914. ○ Tumbes. Quelques activités en cours. Voici quelques exemples des travaux de recherche appuyés par le CRDI au Pérou. □ Amélioration des pratiques agricoles pour lutter contre le paludisme. Financement : 500 400 CAD. Période visée : de 2012 à 2016.

  18. Genome-Wide Gene/Genome Dosage Imbalance Regulates Gene Expressions in Synthetic Brassica napus and Derivatives (AC, AAC, CCA, CCAA).

    Science.gov (United States)

    Tan, Chen; Pan, Qi; Cui, Cheng; Xiang, Yi; Ge, Xianhong; Li, Zaiyun

    2016-01-01

    Gene/genome dosage balance is an essential evolutionary mechanism for organisms to ensure a normal function, but the underlying causes of dosage-imbalance regulation remain poorly understood. Herein, the serial Brassica hybrids/polyploids (AC, AAC, CCA, CCAA) with different copies of A and C subgenomes from the same two parents of Brassica rapa and Brassica oleracea were synthesized to investigate the effects of genome dosages on gene expressions and interactions by using RNA-Seq. The expression changes of A- and C-subgenome genes were consistent with dosage alterations. Dosage-dependent and -independent genes were grouped according to the correlations between dosage variations and gene expressions. Expression levels of dosage-dependent genes were strongly correlated with dosage changes and mainly contributed to dosage effects, while those of dosage-independent genes gave weak correlations with dosage variations and mostly facilitated dosage compensation. More protein-protein interactions were detected for dosage-independent genes than dosage-dependent ones, as predicted by the dosage balance hypothesis. Dosage-dependent genes more likely impacted the expressions by trans effects, whereas dosage-independent genes preferred to play by cis effects. Furthermore, dosage-dependent genes were mainly associated with the basic biological processes to maintain the stability of the growth and development, while dosage-independent genes were more enriched in the stress response related processes to accelerate adaptation. The present comprehensive analysis of gene expression dependent/independent on dosage alterations in Brassica polyploids provided new insights into gene/genome dosage-imbalance regulation of gene expressions.

  19. Characterization of Au and Bimetallic PtAu Nanoparticles on PDDA-Graphene Sheets as Electrocatalysts for Formic Acid Oxidation

    Science.gov (United States)

    Yung, Tung-Yuan; Liu, Ting-Yu; Huang, Li-Ying; Wang, Kuan-Syun; Tzou, Huei-Ming; Chen, Po-Tuan; Chao, Chi-Yang; Liu, Ling-Kang

    2015-09-01

    Nanocomposite materials of the Au nanoparticles (Au/PDDA-G) and the bimetallic PtAu nanoparticles on poly-(diallyldimethylammonium chloride) (PDDA)-modified graphene sheets (PtAu/PDDA-G) were prepared with hydrothermal method at 90 °C for 24 h. The composite materials Au/PDDA-G and PtAu/PDDA-G were evaluated by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA) for exploring the structural characterization for the electrochemical catalysis. According to TEM results, the diameter of Au and bimetallic PtAu nanoparticles is about 20-50 and 5-10 nm, respectively. X-ray diffraction (XRD) results indicate that both of PtAu and Au nanoparticles exhibit the crystalline plane of (111), (200), (210), and (311). Furthermore, XRD data also show the 2°-3° difference between pristine graphene sheets and the PDDA-modified graphene sheets. For the catalytic activity tests of Au/PDDA-G and PtAu/PDDA-G, the mixture of 0.5 M aqueous H2SO4 and 0.5 M aqueous formic acid was used as model to evaluate the electrochemical characterizations. The catalytic activities of the novel bimetallic PtAu/graphene electrocatalyst would be anticipated to be superior to the previous electrocatalyst of the cubic Pt/graphene.

  20. Role of water in the physical stability of solid dosage formulations

    DEFF Research Database (Denmark)

    Airaksinen, Sari; Karjalainen, Milja; Shevchenko, Anna

    2005-01-01

    The interaction of moisture with pharmaceutical solids is highly crucial to an understanding of water-based processes, for example, manufacturing processes or prediction of solid dosage form stability and shelf life. Both the active pharmaceutical ingredient (API) and excipients in the formulation...... have different moisture sorption properties that can result in unexpected processing-induced phase transitions and they can affect solid-state phase transitions in the final dosage forms. The character of excipient effects on the stability of formulation. Phase transformations in formulations can lead...... during heating. These results showed that despite some limitations, moisture sorption isotherms of excipients are useful in predicting solid-state stability, interactions at early stages of formulation development, and effects of moisture on physicochemical properties of the final dosage forms....

  1. Optimal Antibiotic Dosage for Chronic Kidney Disease Patient: A Pharmacological Manual for Oral Clinicians.

    Science.gov (United States)

    Chidambaram, Ramasamy

    2015-01-01

    Chronic kidney disease, (CKD) a gradual and inevitable deterioration in renal function, is the disease with the most associations in dentistry. Dosage adjustment is one amongst the vital elements to be familiar with during their oral care. CKD patients take extended duration to filter out medications, therefore dosage must always be tailored under the supervision of nephrologist. The relished benefits from antibiotic could transform as anti-microbial resistance on their abuse and nephrotoxic when contraindicated drugs are encouraged. New patented drug belonging to oxazoliodine group has driven the researchers to handle the emerging AMR. The present communication discusses the pharmacological factors influencing in prescribing the antibiotics for CKD patient from the dentist's point of view. The formulas destined for calculating the optimal dosage of antibiotics have been documented to aid oral physicians.

  2. Large-scale population study of human cell lines indicates that dosage compensation is virtually complete.

    Directory of Open Access Journals (Sweden)

    Colette M Johnston

    2008-01-01

    Full Text Available X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.

  3. Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms.

    Science.gov (United States)

    Leane, M M; Nankervis, R; Smith, A; Illum, L

    2004-03-01

    This study evaluated and optimised the ninhydrin assay as a tool for measuring the in vitro release and dissolution of chitosan from solid dosage forms. The precision and accuracy of the assay for the type of chitosan used in the study were examined by measuring the inter- and intra-sample variation and found to be within acceptable limits. The assay was applied practically to construct a pH/solubility profile for chitosan and subsequently to measure the release and dissolution of chitosan from dosage forms in the presence and absence of a model drug, sodium salicylate. Assay performance was found to be satisfactory over a wide range of physiologically relevant pH values. It is concluded that the ninhydrin assay is an essential aid in the design and testing of solid dosage forms with different chitosan-drug release profiles.

  4. Cumulative dosages of antipsychotic drugs are associated with increased mortality rate in patients with Alzheimer's dementia

    DEFF Research Database (Denmark)

    Nielsen, René; Lolk, A; Valentin, J B

    2016-01-01

    OBJECTIVE: We wished to investigate the effects of cumulative dosages of antipsychotic drug in Alzheimer's dementia, when controlling for known risk factors, including current antipsychotic exposure, on all-cause mortality. METHOD: We utilized a nationwide, population-based, retrospective cohort...... mortality: more than 0 Daily Defined Dosage (DDDs) but less than 90: HR 2.20, 95% CI (2.14-2.27), P ... or equal to 730 DDDs: HR 1.06, 95% CI (0.95-1.18), P = 0.322, when controlling for proxy markers of severity, somatic and mental comorbid disorders. CONCLUSION: In this nationwide cohort study of 45 894 patients diagnosed with Alzheimer's dementia, we found that cumulative dosages of antipsychotic drugs...

  5. Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage.

    Science.gov (United States)

    Maniar, Kevin H; Jones, Ian A; Gopalakrishna, Rayudu; Vangsness, C Thomas

    2018-02-01

    Osteoarthritis is a burdensome disease that causes progressive damage to articular cartilage. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the preferred treatments for symptomatic relief. However, NSAIDs can cause serious dose-dependent side effects, which has prompted experts to recommend the minimization of NSAID dosage. Areas covered: This review focuses on three broad strategies that are currently being investigated or implemented to minimize NSAID dosage: nano-formulation, encapsulation, and topical delivery. The benefits, challenges and current status of these methods are discussed. Expert opinion: Multiple strategies are under investigation to lower NSAID dosage. There is great potential in developing formulations that utilize more than one of these strategies together. However, there are challenges to developing these lower dose preparations. In order to maximize the clinical potential of the abundance of NSAIDs that are both available and being developed, there is a major need for additional clinical studies directly comparing safety and efficacy of different preparations.

  6. An evolutionary consequence of dosage compensation on Drosophila melanogaster female X-chromatin structure?

    Directory of Open Access Journals (Sweden)

    Oliver Brian

    2010-01-01

    Full Text Available Abstract Background X chromosomes are subject to dosage compensation in Drosophila males. Dosage compensation requires cis sequence features of the X chromosome that are present in both sexes by definition and trans acting factors that target chromatin modifying machinery to the X specifically in males. The evolution of this system could result in neutral X chromatin changes that will be apparent in females. Results We find that the general chromatin structure of female X chromosomes is distinct from autosomes. Additionally, specific histone marks associated with dosage compensation and active chromatin marks on the male X chromosome are also enriched on the X chromosomes of females, albeit to a lesser degree. Conclusions Our data indicate that X chromatin structure is fundamentally different from autosome structure in both sexes. We suggest that the differences between the X chromosomes and autosomes in females are a consequence of mechanisms that have evolved to ensure sufficient X chromosome expression in the soma of males.

  7. Dominance and gene dosage balance in health and disease: why levels matter!

    Science.gov (United States)

    Veitia, Reiner A; Birchler, James A

    2010-01-01

    The classical concept of genetic dominance is a simplification of a more quantitative reality. This is clearly exemplified by aneuploid syndromes, of which the best known case is trisomy 21. Moreover, there is an increasing number of clinical conditions due to reduced dosage (haploinsufficiency) of genes encoding transcription factors and other proteins involved in signal transduction and macromolecular complexes. In such genetic diseases, a high degree of phenotypic variability is observed, which calls for an explanation. The sources of dominance are heterogeneous and difficult to cover in a brief review. Here, we will focus on the molecular bases of dosage-sensitive syndromes from the perspective of the gene dosage balance hypothesis, which postulates that stoichiometric alterations of macromolecular complexes or cellular networks are responsible for dominant phenotypes, because of the existing non-linear relationships between the genotypic and phenotypic values with which they are associated.

  8. Des institutions au service de villes sûres et inclusives au Venezuela

    International Development Research Centre (IDRC) Digital Library (Canada)

    Caracas, au Venezuela, est l'une des villes les plus violentes au monde; il s'y commet 122 homicides par tranche de 100 000 habitants. Selon les experts en violence urbaine, les inégalités sociales et la disparité des revenus sont étroitement liées à l'ampleur de la violence, mais cette théorie ne tient pas dans le cas ...

  9. Prévention de la violence chez les jeunes au Guatemala, au ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La violence chez les jeunes, que ceux-ci en soient victimes ou responsables, est l'un des problèmes les plus importants en Amérique centrale. Ce projet de recherche servira à évaluer les stratégies actuelles de prévention de la violence chez les jeunes dans le triangle nord de la région, soit au Salvador, au Guatemala et ...

  10. Directed Flow of Light Nuclei in Au+Au Collisions at AGS Energies

    OpenAIRE

    E877 Collaboration; Barrette, J.; Bellwied, R.; Bennett, S.; Bersch, R.; Braun-Munzinger, P.; Chang, W. C.; Cleland, W. E.; Clemen, M.; Cole, J.; Cormier, T. M.; Dai, Y.; David, G.; Dee, J.; Dietzsch, O.

    1998-01-01

    Directed flow of deuterons, tritons, $^3$He, and $^4$He is studied in Au+Au collisions at a beam momentum of about 10.8 $A$ GeV/c. Flow of all particles is analyzed as a function of transverse momentum for different centralities of the collision. The directed flow signal, $v_1(p_t)$, is found to increase with particle mass. This mass dependence is strongest in the projectile rapidity region.

  11. A first look at Au·Au collisions at RHIC energies using the PHOBOS ...

    Indian Academy of Sciences (India)

    A first look at Au·Au collisions at RHIC energies using the PHOBOS detector. BIRGER BACK1, for the PHOBOS Collaboration. M D Baker2, D S Barton2, R R Betts6, R Bindel7, A Budzanowski3, W Busza4,. A Carroll2, J Corbo2, M P Decowski4, E Garcia6, N George1, K Gulbrandsen4, S Gushue2,. C Halliwell6, J Hamblen8, ...

  12. Flow and bose-einstein correlations in Au-Au collisions at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Manly, Steven; Back, B.B.; Baker, M.D.; Barton, D.S.; Betts, R.R.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Decowski, M.P.; Garcia, E.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Henderson, C.; Hofman, D.; Hollis, R.S.; Holyinski, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J.; Katzy, J.; Khan, N.; Kucewicz, W.; Kulinich, P.; Kuo, C.M.; Lin, W.T.; Manly, S.; McLeod, D.; Michalowski, J.; Mignerey, A.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I.C.; Pernegger, H.; Reed, C.; Remsberg, L.P.; Reuter, M.; Roland, C.; Roland, G.; Rosenberg, L.; Sagerer, J.; Sarin, P.; Sawicki, P.; Skulski, W.; Steadman, S.G.; Steinberg, P.; Stephans, G.S.F.; Stodulski, M.; Sukhanov, A.; Tang, J.-L.; Teng, R.; Trzupek, A.; Vale, C.; Nieuwenhuizen, G.J. van; Verdier, R.; Wadsworth, B.; Wolfs, F.L.H.; Wosiek, B.; Wozniak, K.; Wuosmaa, A.H.; Wyslouch, B

    2003-03-10

    Argonne flow and Bose-Einstein correlations have been measured in Au-Au collisions at {radical}S{sub NN} = 130 and 200 GeV using the PHOBOS detector at RHIC. The systematic dependencies of the flow signal on the transverse momentum, pseudorapidity, and centrality of the collision, as well as the beam energy are shown. In addition, results of a 3-dimensional analysis of two-pion correlations in the 200 GeV data are presented.

  13. Femmes, migration et droits au Mali et au Sénégal | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En Afrique de l'Ouest, notamment au Mali et au Sénégal, les migrations féminines concernent majoritairement les flux d'une part à l'intérieur des pays et d'autre part entre les pays. Du fait de la pauvreté, manque d'opportunités économiques et manque d'éducation, les jeunes filles migrantes risquent de subir des violations ...

  14. Measuring dosage: a key factor when assessing the relationship between prenatal case management and birth outcomes.

    Science.gov (United States)

    Slaughter, Jaime C; Issel, L Michele; Handler, Arden S; Rosenberg, Deborah; Kane, Debra J; Stayner, Leslie T

    2013-10-01

    To assess whether a measure of prenatal case management (PCM) dosage is more sensitive than a dichotomous PCM exposure measure when evaluating the effect of PCM on low birthweight (LBW) and preterm birth (PTB). We constructed a retrospective cohort study (N = 16,657) of Iowa Medicaid-insured women who had a singleton live birth from October 2005 to December 2006; 28 % of women received PCM. A PCM dosage measure was created to capture duration of enrollment, total time with a case manager, and intervention breadth. Propensity score (PS)-adjusted odds ratios (ORs), and 95 % confidence intervals (95 % CIs) were calculated to assess the risk of each outcome by PCM dosage and the dichotomous PCM exposure measure. PS-adjusted ORs of PTB were 0.88 (95 % CI 0.70-1.11), 0.58 (95 % CI 0.47-0.72), and 1.43 (95 % CI 1.23-1.67) for high, medium, and low PCM dosage, respectively. For LBW, the PS-adjusted ORs were 0.76 (95 % CI 0.57-1.00), 0.64 (95 % CI 0.50-0.82), and 1.36 (95 % CI 1.14-1.63), for high, medium, and low PCM dosage, respectively. The PCM dichotomous participation measure was not significantly associated with LBW (OR = 0.95, 95 % CI 0.82-1.09) or PTB (0.97, 95 % CI 0.87-1.10). The reference group in each analysis is No PCM. PCM was associated with a reduced risk of adverse pregnancy outcomes for Medicaid-insured women in Iowa. PCM dosage appeared to be a more sensitive measure than the dichotomous measure of PCM participation.

  15. Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances.

    Science.gov (United States)

    Fernández, Ariel; Tzeng, Yun-Huei; Hsu, Sze-Bi

    2011-12-14

    Driven essentially by random genetic drift, subfunctionalization has been identified as a possible non-adaptive mechanism for the retention of duplicate genes in small-population species, where widespread deleterious mutations are likely to cause complementary loss of subfunctions across gene copies. Through subfunctionalization, duplicates become indispensable to maintain the functional requirements of the ancestral locus. Yet, gene duplication produces a dosage imbalance in the encoded proteins and thus, as investigated in this paper, subfunctionalization must be subject to the selective forces arising from the fitness bottleneck introduced by the duplication event. We show that, while arising from random drift, subfunctionalization must be inescapably subject to selective forces, since the diversification of expression patterns across paralogs mitigates duplication-related dosage imbalances in the concentrations of encoded proteins. Dosage imbalance effects become paramount when proteins rely on obligatory associations to maintain their structural integrity, and are expected to be weaker when protein complexation is ephemeral or adventitious. To establish the buffering effect of subfunctionalization on selection pressure, we determine the packing quality of encoded proteins, an established indicator of dosage sensitivity, and correlate this parameter with the extent of paralog segregation in humans, using species with larger population -and more efficient selection- as controls. Recognizing the role of subfunctionalization as a dosage-imbalance buffer in gene duplication events enabled us to reconcile its mechanistic nonadaptive origin with its adaptive role as an enabler of the evolution of genetic redundancy. This constructive role was established in this paper by proving the following assertion: If subfunctionalization is indeed adaptive, its effect on paralog segregation should scale with the dosage sensitivity of the duplicated genes. Thus

  16. [Development of semisolid dosage form of clonazepam for oral cavity administration].

    Science.gov (United States)

    Sakata, Osamu; Onishi, Hiraku; Machida, Yoshiharu

    2010-01-01

    A semisolid dosage form of clonazepam (CZP), administered to the oral cavity between the lower gum and bottom lip with small volume of saline, was developed to obtain the stable dosage which can replace the injection dosage form. Semisolid dosage forms were prepared using a mixture of CZP/(polyethylene glycol 1500 (PEG))/(oleic acid (OA)) at the ratios of 1/39/0, 1/37/2 and 2/36/2 (w/w), named CZP1-PEG, CZP1-PEG-OA and CZP2-PEG-OA, respectively, and were evaluated in vitro and in vivo. No crystal of CZP was observed in CZP1-PEG-OA for at least 8 days, while CZP crystal appeared before administration for CZP2-PEG-OA. When a small volume of saline was added to CZP1-PEG-OA just before the oral cavity administration, more than 80% (w/w) was found to exist in the soluble form. Each semisolid dosage form (40 mg) was administered to the oral cavity in rats, and CZP 1 mg suspension in 0.5% (w/v) sodium carboxymethylcellulose aqueous solution was administered into rat stomach as a control. CZP1-PEG-OA gave the plasma concentrations of more than 5 ng/ml and 12 ng/ml at 30 min and 1 h after administration, respectively, which might be near the plasma levels effective for the suppression of epileptic seizures in human, while the plasma concentration was less than 5 ng/ml at 30 min or did not reach 10 ng/ml at 1 h for the other formulations. It is proposed that the semisolid dosage form CZP1-PEG-OA should be a possibly useful preparation for the antiepileptic or sedative medication.

  17. Application methods and dosages of thiamethoxam in thrips control on tomato plants

    Directory of Open Access Journals (Sweden)

    Raetano Carlos Gilberto

    2003-01-01

    Full Text Available Thrips is one of the most important vector species of the tomato spotted wilt tospovirus (TSWV in Brazil. Two different pesticide application methods, drench x spray, using thiamethoxam were compared with commonly used insecticides for thrips control in tomato plants, Debora Plus. The experimental design consisted of a complete randomized block design with seven treatments and four replicates. Dosages of 150 and 200 g of a.i. per ha were used in just one drench application and 50 g of a.i. ha-1 sprayed, at weekly intervals, 48 days after sowing. The control efficacy of thiamethoxam was compared to diafenthiuron (400 g of a.i. ha-1, profenofos + cypermethrin (320+32 g of a.i. ha-1, respectively and methamidophos (60 g of a.i. per hectolitre of water in spray application. Cumulative number of plants with tospoviruses and the F. schultzei population from ten flowers per plot were registered. The mean cumulative number of plants with tospoviruses among treatments was not significantly different. No significant difference between thiamethoxam application methods and dosages on F. schultzei control, 24 days after application, were observed for thrips population. One drench application of higher dosages of thiamethoxam proved to be more environmentally advantageous than the pesticide applied at dosages of 50 g of a.i. ha-1 at weekly intervals. The vector control efficacy of thiamethoxam varied from 93 to 95%, independently of the application method and dosages. Diafenthiuron and profenofos + cypermethrin showed less efficacy (78 and 88%, respectively but greater than those with methamidophos (71%. The products and dosages tested did not cause phytotoxicity in tomato leaves.

  18. Recruitment of C. elegans dosage compensation proteins for gene-specific versus chromosome-wide repression.

    Science.gov (United States)

    Yonker, Stephanie A; Meyer, Barbara J

    2003-12-01

    In C. elegans, an X-chromosome-wide regulatory process compensates for the difference in X-linked gene dose between males (XO) and hermaphrodites (XX) by equalizing levels of X-chromosome transcripts between the sexes. To achieve dosage compensation, a large protein complex is targeted to the X chromosomes of hermaphrodites to reduce their expression by half. This repression complex is also targeted to a single autosomal gene, her-1. By silencing this male-specific gene, the complex induces hermaphrodite sexual development. Our analysis of the atypical dosage compensation gene dpy-21 revealed the first molecular differences in the complex that achieves gene-specific versus chromosome-wide repression. dpy-21 mutations, shown here to be null, cause elevated X-linked gene expression in XX animals, but unlike mutations in other dosage compensation genes, they do not cause extensive XX-specific lethality or disrupt the stability or targeting of the dosage compensation complex to X. Nonetheless, DPY-21 is a member of the dosage compensation complex and localizes to X chromosomes in a hermaphrodite-specific manner. However, DPY-21 is the first member of the dosage compensation complex that does not also associate with her-1. In addition to a difference in the composition of the complex at her-1 versus X, we also found differences in the targeting of the complex to these sites. Within the complex, SDC-2 plays the lead role in recognizing X-chromosome targets, while SDC-3 plays the lead in recognizing her-1 targets.

  19. Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances

    Directory of Open Access Journals (Sweden)

    Fernández Ariel

    2011-12-01

    Full Text Available Abstract Background Driven essentially by random genetic drift, subfunctionalization has been identified as a possible non-adaptive mechanism for the retention of duplicate genes in small-population species, where widespread deleterious mutations are likely to cause complementary loss of subfunctions across gene copies. Through subfunctionalization, duplicates become indispensable to maintain the functional requirements of the ancestral locus. Yet, gene duplication produces a dosage imbalance in the encoded proteins and thus, as investigated in this paper, subfunctionalization must be subject to the selective forces arising from the fitness bottleneck introduced by the duplication event. Results We show that, while arising from random drift, subfunctionalization must be inescapably subject to selective forces, since the diversification of expression patterns across paralogs mitigates duplication-related dosage imbalances in the concentrations of encoded proteins. Dosage imbalance effects become paramount when proteins rely on obligatory associations to maintain their structural integrity, and are expected to be weaker when protein complexation is ephemeral or adventitious. To establish the buffering effect of subfunctionalization on selection pressure, we determine the packing quality of encoded proteins, an established indicator of dosage sensitivity, and correlate this parameter with the extent of paralog segregation in humans, using species with larger population -and more efficient selection- as controls. Conclusions Recognizing the role of subfunctionalization as a dosage-imbalance buffer in gene duplication events enabled us to reconcile its mechanistic nonadaptive origin with its adaptive role as an enabler of the evolution of genetic redundancy. This constructive role was established in this paper by proving the following assertion: If subfunctionalization is indeed adaptive, its effect on paralog segregation should scale with the dosage

  20. The effect of decreasing computed tomography dosage on radiostereometric analysis (RSA) accuracy at the glenohumeral joint.

    Science.gov (United States)

    Fox, Anne-Marie V; Kedgley, Angela E; Lalone, Emily A; Johnson, James A; Athwal, George S; Jenkyn, Thomas R

    2011-11-10

    Standard, beaded radiostereometric analysis (RSA) and markerless RSA often use computed tomography (CT) scans to create three-dimensional (3D) bone models. However, ethical concerns exist due to risks associated with CT radiation exposure. Therefore, the aim of this study was to investigate the effect of decreasing CT dosage on RSA accuracy. Four cadaveric shoulder specimens were scanned using a normal-dose CT protocol and two low-dose protocols, where the dosage was decreased by 89% and 98%. 3D computer models of the humerus and scapula were created using each CT protocol. Bi-planar fluoroscopy was used to image five different static glenohumeral positions and two dynamic glenohumeral movements, of which a total of five static and four dynamic poses were selected for analysis. For standard RSA, negligible differences were found in bead (0.21±0.31mm) and bony landmark (2.31±1.90mm) locations when the CT dosage was decreased by 98% (p-values>0.167). For markerless RSA kinematic results, excellent agreement was found between the normal-dose and lowest-dose protocol, with all Spearman rank correlation coefficients greater than 0.95. Average root mean squared errors of 1.04±0.68mm and 2.42±0.81° were also found at this reduced dosage for static positions. In summary, CT dosage can be markedly reduced when performing shoulder RSA to minimize the risks of radiation exposure. Standard RSA accuracy was negligibly affected by the 98% CT dose reduction and for markerless RSA, the benefits of decreasing CT dosage to the subject outweigh the introduced errors. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. A reagentless amperometric immunosensor based on nano-au and ...

    African Journals Online (AJOL)

    In this paper, carboxyl-ferrocene (Fc-COOH) was explored to label alphafetoprotein antibody (anti-AFP), which was then mixed with AU nanoparticles (nano-Au) and multi-walled carbon nanotubes (MWCNTs) dispersed by chitosan (CS) to form the nano-Au/MWCNTs/anti-AFP-Fc chitosan composite. After that, the composite ...

  2. Au pair på ulige vilkår

    DEFF Research Database (Denmark)

    Christiansen, Connie Carøe

    2008-01-01

    Antallet af au pairs i Danmark fra Fillipinerne er steget markant i de seneste år. Mens danske myndigheder betragter au pair-ordningen som kulturudveksling blandt unge mennesker, ser fillipinske au pairs derimod den som en mulighed for at tjene penge så de kan forsørge deres egen familie i Fillip...

  3. The point-defect of carbon nanotubes anchoring Au nanoparticles

    DEFF Research Database (Denmark)

    Lv, Y. A.; Cui, Y. H.; Li, X. N.

    2010-01-01

    between Au clusters and CNTs by means of density functional theory calculations. Both experimental and theoretical studies show that point defects are the anchoring sites of Au nanoparticles. The mechanisms of enhanced bond between Au and CNTs via the point defects are explained by the analysis of density...

  4. Common suppression pattern of η and π0 mesons at high transverse momentum in Au+Au collisions at VsNN=200 GeV

    NARCIS (Netherlands)

    Peitzmann, T.

    2006-01-01

    Inclusive transverse momentum spectra of η mesons have been measured within pT=2–10 GeV/c at midrapidity by the PHENIX experiment in Au+Au collisions at VsNN=200 GeV. In central Au+Au the η yields are significantly suppressed compared to peripheral Au+Au, d+Au, and p+p yields scaled by the

  5. Electronic and geometric structures of Au30 clusters: a network of 2e-superatom Au cores protected by tridentate protecting motifs with u3-S.

    Science.gov (United States)

    Tian, Zhimei; Cheng, Longjiu

    2016-01-14

    Density functional theory calculations have been performed to study the experimentally synthesized Au30S(SR)18 and two related Au30(SR)18 and Au30S2(SR)18 clusters. The patterns of thiolate ligands on the gold cores for the three thiolate-protected Au30 nanoclusters are on the basis of the "divide and protect" concept. A novel extended protecting motif with u3-S, S(Au2(SR)2)2AuSR, is discovered, which is termed the tridentate protecting motif. The Au cores of Au30S(SR)18, Au30(SR)18 and Au30S2(SR)18 clusters are Au17, Au20 and Au14, respectively. The superatom-network (SAN) model and the superatom complex (SAC) model are used to explain the chemical bonding patterns, which are verified by chemical bonding analysis based on the adaptive natural density partitioning (AdNDP) method and aromatic analysis on the basis of the nucleus-independent chemical shift (NICS) method. The Au17 core of the Au30S(SR)18 cluster can be viewed as a SAN of one Au6 superatom and four Au4 superatoms. The shape of the Au6 core is identical to that revealed in the recently synthesized Au18(SR)14 cluster. The Au20 core of the Au30(SR)18 cluster can be viewed as a SAN of two Au6 superatoms and four Au4 superatoms. The Au14 core of Au30S2(SR)18 can be regarded as a SAN of two pairs of two vertex-sharing Au4 superatoms. Meanwhile, the Au14 core is an 8e-superatom with 1S(2)1P(6) configuration. Our work may aid understanding and give new insights into the chemical synthesis of thiolate-protected Au clusters.

  6. The effect of Au amount on size uniformity of self-assembled Au nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Chen, S-H; Wang, D-C; Chen, G-Y; Chen, K-Y [Graduate School of Engineering Science and Technology, National Yunlin University of Science and Technology, Taiwan (China)

    2008-03-15

    The self-assembled fabrication of nanostructure, a dreaming approach in the area of fabrication engineering, is the ultimate goal of this research. A finding was proved through previous research that the size of the self-assembled gold nanoparticles could be controlled with the mole ratio between AuCl{sub 4}{sup -} and thiol. In this study, the moles of Au were fixed, only the moles of thiol were adjusted. Five different mole ratios of Au/S with their effect on size uniformity were investigated. The mole ratios were 1:1/16, 1:1/8, 1:1, 1:8, 1:16, respectively. The size distributions of the gold nanoparticles were analyzed by Mac-View analysis software. HR-TEM was used to derive images of self-assembled gold nanoparticles. The result reached was also the higher the mole ratio between AuCl{sub 4}{sup -} and thiol the bigger the self-assembled gold nanoparticles. Under the condition of moles of Au fixed, the most homogeneous nanoparticles in size distribution derived with the mole ratio of 1:1/8 between AuCl{sub 4}{sup -} and thiol. The obtained nanoparticles could be used, for example, in uniform surface nanofabrication, leading to the fabrication of ordered array of quantum dots.

  7. Effects of Excimer Irradiation Treatment on Thermocompression Au-Au Bonding

    Science.gov (United States)

    Naoko Unami,; Katsuyuki Sakuma,; Jun Mizuno,; Shuichi Shoji,

    2010-06-01

    We studied the feasibility of using vacuum ultraviolet (VUV) treatment as a surface improvement technique with Au-Au flip-chip bonding. For fine-pitch electrical interconnections in three-dimensional (3D) stack applications, robust and reliable bonding is desirable; in this case, surface modification treatment is needed before the bonding process. A VUV surface treatment was used to remove organic contaminants. Samples of electroplated Au pads were examined by X-ray photoelectron spectroscopy (XPS) to evaluate the chemical composition of the Au surfaces. The XPS results revealed that the carbon-based contaminants on the surface were removed by the VUV treatment. The shear strength of the bonded sample was also improved. The average shear strength of a bump with VUV treatment is 1.6 times larger than that of a bump without VUV treatment. Cross-sectional scanning electron microscopy (SEM) images of the bonded samples confirmed the absence of voids and cracks. The results show that VUV treatment has clear effects on Au-Au flip-chip bonding.

  8. Results from the PHOBOS Experiment on Au+Au Collisions at RHIC

    CERN Document Server

    Wozniak, K; Baker, M D; Barton, D S; Basilev, S N; Baum, R; Betts, R R; Bialas, A; Bindel, R; Bogucki, W; Budzanowski, A; Busza, W; Carroll, A; Ceglia, M; Chang, Y H; Chen, A E; Coghen, T; Conner, C L; Czyz, W; Dabrowski, B; Decowski, M P; Despet, M; Fita, P; Fitch, J; Friedl, M; Galuszka, K; Ganz, R E; García-Solis, E; George, N; Godlewski, J; Gomes, C; Griesmayer, E; Gulbrandsen, K H; Gushue, S; Halik, J; Halliwell, C; Haridas, P; Hayes, A; Heintzelman, G A; Henderson, C; Hollis, R; Holynski, R; Holzman, B; Johnson, E; Kane, J; Katzy, J M; Kita, W; Kotula, J; Kraner, H W; Kucewicz, W; Kulinich, P A; Law, C; Lemler, M A; Ligocki, T J; Lin, W T; Manly, S L; McLeod, D; Michalowski, J; Mignerey, A C; Mülmenstädt, J; Neal, M; Nouicer, R; Olszewski, A; Pak, R; Park, I C; Patel, M; Pernegger, H; Plesko, M; Reed, C; Remsberg, L P; Reuter, M; Roland, C; Roland, G; Ross, D; Rosenberg, L J; Ryan, J; Sanzgiri, A; Sarin, P; Sawicki, P; Scaduto, J; Shea, J; Sinacore, J; Skulski, W; Steadman, S G; Stephans, G S F; Steinberg, P; Straczek, A; Stodulski, M; Strek, M; Stopa, Z; Sukhanov, A; Surowiecka, K; Tang, J L; Teng, R; Trzupek, A; Vale, C J; van Nieuwenhuizen, G J; Verdier, R; Wadsworth, B; Wolfs, F L H; Wosiek, B; Wozniak, K; Wuosmaa, A H; Wyslouch, B; Zalewski, Kasper

    2001-01-01

    PHOBOS is one of four experiments studying the Au-Au interactions at RHIC. The data collected during the first few weeks after the RHIC start-up, using the initial configuration of the PHOBOS detector, were sufficient to obtain the first physics results for the most central collisions of Au nuclei at the center of mass energy of 56 and 130 AGeV. The pseudorapidity density of charged particles near midrapidity is shown and compared with data at lower energies and from $pp$ and $p\\bar{p}$ collisions. The progress of the analysis of the data is also presented.PHOBOS is one of four experiments studying the Au-Au interactions at RHIC. The data collected during the first few weeks after the RHIC start-up, using the initial configuration of the PHOBOS detector, were sufficient to obtain the first physics results for the most central collisions of Au nuclei at the center of mass energy of 56 and 130 AGeV. The pseudorapidity density of charged particles near midrapidity is shown and compared with data at lower energie...

  9. Au(I/Au(III-catalyzed Sonogashira-type reactions of functionalized terminal alkynes with arylboronic acids under mild conditions

    Directory of Open Access Journals (Sweden)

    Deyun Qian

    2011-06-01

    Full Text Available A straightforward, efficient, and reliable redox catalyst system for the Au(I/Au(III-catalyzed Sonogashira cross-coupling reaction of functionalized terminal alkynes with arylboronic acids under mild conditions has been developed.

  10. Genome-Wide Dosage-Dependent and -Independent Regulation Contributes to Gene Expression and Evolutionary Novelty in Plant Polyploids.

    Science.gov (United States)

    Shi, Xiaoli; Zhang, Changqing; Ko, Dae Kwan; Chen, Z Jeffrey

    2015-09-01

    Polyploidy provides evolutionary and morphological novelties in many plants and some animals. However, the role of genome dosage and composition in gene expression changes remains poorly understood. Here, we generated a series of resynthesized Arabidopsis tetraploids that contain 0-4 copies of Arabidopsis thaliana and Arabidopsis arenosa genomes and investigated ploidy and hybridity effects on gene expression. Allelic expression can be defined as dosage dependent (expression levels correlate with genome dosages) or otherwise as dosage independent. Here, we show that many dosage-dependent genes contribute to cell cycle, photosynthesis, and metabolism, whereas dosage-independent genes are enriched in biotic and abiotic stress responses. Interestingly, dosage-dependent genes tend to be preserved in ancient biochemical pathways present in both plant and nonplant species, whereas many dosage-independent genes belong to plant-specific pathways. This is confirmed by an independent analysis using Arabidopsis phylostratigraphic map. For A. thaliana loci, the dosage-dependent alleles are devoid of TEs and tend to correlate with H3K9ac, H3K4me3, and CG methylation, whereas the majority of dosage-independent alleles are enriched with TEs and correspond to H3K27me1, H3K27me3, and CHG (H = A, T, or C) methylation. Furthermore, there is a parent-of-origin effect on nonadditively expressed genes in the reciprocal allotetraploids especially when A. arenosa is used as the pollen donor, leading to metabolic and morphological changes. Thus, ploidy, epigenetic modifications, and cytoplasmic-nuclear interactions shape gene expression diversity in polyploids. Dosage-dependent expression can maintain growth and developmental stability, whereas dosage-independent expression can facilitate functional divergence between homeologs (subfunctionalization and/or neofunctionalization) during polyploid evolution. © The Author 2015. Published by Oxford University Press on behalf of the Society for

  11. From the Ternary Eu(Au/In)2 and EuAu4(Au/In)2 with Remarkable Au/In Distributions to a New Structure Type: The Gold-Rich Eu5Au16(Au/In)6 Structure.

    Science.gov (United States)

    Steinberg, Simon; Card, Nathan; Mudring, Anja-Verena

    2015-09-08

    The ternary Eu(Au/In)2 (EuAu(0.46)In(1.54(2))) (I), EuAu4(Au/In)2 (EuAu(4+x)In(2-x) with x = 0.75(2) (II), 0.93(2), and 1.03(2)), and Eu5Au16(Au/In)6 (Eu5Au(17.29)In(4.71(3))) (III) have been synthesized, and their structures were characterized by single-crystal X-ray diffraction. I and II crystallize with the CeCu2-type (Pearson Symbol oI12; Imma; Z = 4; a = 4.9018(4) Å; b = 7.8237(5) Å; c = 8.4457(5) Å) and the YbAl4Mo2-type (tI14; I4/mmm; Z = 2; a = 7.1612(7) Å; c = 5.5268(7) Å) and exhibit significant Au/In disorder. I is composed of an Au/In-mixed diamond-related host lattice encapsulating Eu atoms, while the structure of II features ribbons of distorted, squared Au8 prisms enclosing Eu, Au, and In atoms. Combination of these structural motifs leads to a new structure type as observed for Eu5Au16(Au/In)6 (Eu5Au(17.29)In(4.71(3))) (oS108; Cmcm; Z = 4; a = 7.2283(4) Å; b = 9.0499(6) Å; c = 34.619(2) Å), which formally represents a one-dimensional intergrowth of the series EuAu2-"EuAu4In2". The site preferences of the disordered Au/In positions in II were investigated for different hypothetical "EuAu4(Au/In)2" models using the projector-augmented wave method and indicate that these structures attempt to optimize the frequencies of the heteroatomic Au-In contacts. A chemical bonding analysis on two "EuAu5In" and "EuAu4In2" models employed the TB-LMTO-ASA method and reveals that the subtle interplay between the local atomic environments and the bond energies determines the structural and site preferences for these systems.

  12. Short-time, high-dosage penicillin infusion therapy of syphilis

    DEFF Research Database (Denmark)

    Lomholt, Hans; Poulsen, Asmus; Brandrup, Flemming

    2003-01-01

    The optimal dosage and duration of penicillin treatment for the various stages of syphilis are not known. We present data on 20 patients with syphilis (primary, secondary or latent) treated with high-dose, short-time penicillin infusion therapy. Patients were given 10 MIU of penicillin G intraven......The optimal dosage and duration of penicillin treatment for the various stages of syphilis are not known. We present data on 20 patients with syphilis (primary, secondary or latent) treated with high-dose, short-time penicillin infusion therapy. Patients were given 10 MIU of penicillin G...

  13. UV Spectrophotometric Estimation of Acipimox inBulk and Capsule Dosage Form

    Directory of Open Access Journals (Sweden)

    A. Elphine Prabahar

    2009-01-01

    Full Text Available A new simple, rapid, accurate, sensitive and precise spectrophotometric method in ultra violet region has been developed for determination of acipimox (ACX in bulk and capsule dosage form. Acipimox exhibited maximum absorbance at 231 nm with apparent molar absorptivity of 1.5104 × 104 in distilled water. Beer’s law was found to be obeyed in the concentration range 1-10 μg mL-1. Correlation coefficient was found to be 0.9998. The developed method was validated respect to linearity, precision, accuracy. The proposed method is useful for the routine estimation of ACX in bulk and capsule dosage form.

  14. Analysis of molecular interactions in solid dosage forms; challenge to molecular pharmaceutics.

    Science.gov (United States)

    Yamamoto, Keiji; Limwikrant, Waree; Moribe, Kunikazu

    2011-01-01

    The molecular states of active pharmaceutical ingredients (APIs) in pharmaceutical dosage forms strongly affect the properties and quality of a drug. Various important fundamental physicochemical studies were reviewed from the standpoint of molecular pharmaceutics. Mechanochemical effects were evaluated in mixtures of APIs and pharmaceutical additives. Amorphization, complex formation and nanoparticle formation are observed after grinding process depending on the combination of APIs and pharmaceutical additives. Sealed-heating method and mesoporous materials have been used to investigate drug molecular interactions in dosage forms. Molecular states have been investigated using powder X-ray diffraction, thermal analysis, IR, solid state fluorometry, and NMR. © 2011 Pharmaceutical Society of Japan

  15. Apparatus comprising trace element dosage and method for treating raw water in biofilter

    DEFF Research Database (Denmark)

    2015-01-01

    elements such as certain metals (Cu, Co, Cr, Mo, Ni, W, Zn or a mixture thereof). The apparatus comprising - a volume provided with an inlet (2) for raw water and an outlet (3) for water having been subjected to microbial activity, a filter and a trace element dosage device (13) are placed in this volume...... the inlet (2) to the outlet (3) or in the reverse direction, - the trace element dosage device (13) is positioned upstream of the porous filter material and microbial biomass and is configured to dose trace element(s) to the water flowing through the filter. A method for treating raw water by microbial...

  16. Predictors of ovarian response in intrauterine insemination patients and development of a dosage nomogram

    DEFF Research Database (Denmark)

    Freiesleben, Nina La Cour; Lossl, K.; Bogstad, Jeanette Wulff

    2008-01-01

    The objective of this prospective study was to identify predictors of ovarian response in ovulatory patients treated with low-dose recombinant FSH (rFSH), gonadotrophin-releasing hormone antagonist and intrauterine insemination (IUI), and to develop an rFSH dosage nomogram based on the findings.......004) were the strongest independent predictive factors of the number of mature follicles. In conclusion, body weight and antral follicle count may be used to achieve appropriate ovarian response for IUI in ovulatory patients. Based on this, a simple rFSH dosage nomogram was developed for individual ovarian...

  17. The IP6 micelle-stabilized small Ag cluster for synthesizing Ag-Au alloy nanoparticles and the tunable surface plasmon resonance effect

    Science.gov (United States)

    Wang, Na; Wen, Ying; Wang, Yao; Zhang, Rui; Chen, Xiyao; Ling, Bo; Huan, Shuangyan; Yang, Haifeng

    2012-04-01

    The stable small Ag seeds (size in diameter < 10 nm) were obtained in the presence of inositol hexakisphosphoric (IP6) micelles. Then Ag-Au bimetallic nanoparticles were synthesized through a replacement reaction with the rapid interdiffusion process between such small Ag seeds in nanoclusters and HAuCl4. Adjusting the dosage of HAuCl4 resulted in different products, which possessed unique surface plasmon resonances (SPR). The morphologies of the as-made nanoparticles were observed using transmission electron microscopy and field emission scanning electron microscopy and their compositions were determined by energy-dispersive x-ray spectroscopy. Among them, the Ag-Au alloy nanoparticles with the cauliflower-like structure had a suitable SPR for highly sensitive Raman detection application as a surface-enhanced Raman scattering (SERS) substrate with a long-term stability of six months.

  18. In-situ STM study of phosphate adsorption on Cu(111), Au(111) and Cu/Au(111) electrodes

    DEFF Research Database (Denmark)

    Schlaup, Christian; Horch, Sebastian

    2013-01-01

    The interaction of Cu(111), Au(111) and Cu-covered Au(111) electrodes with a neutral phosphate buffer solution has been studied by means of cyclic voltammetry (CV) and in situ electrochemical scanning tunneling microscopy (EC-STM). Under low potential conditions, both the Cu(111) and the Au(111) ...

  19. Tuning the kondo effect in thin Au films by depositing a thin layer of Au on molecular spin-dopants

    NARCIS (Netherlands)

    Ataç, Derya; Gang, T.; Yilmaz, M.D.; Bose, Saurabh; Lenferink, Aufrid T.M.; Otto, Cornelis; de Jong, Machiel Pieter; Huskens, Jurriaan; van der Wiel, Wilfred Gerard

    2013-01-01

    We report on the tuning of the Kondo effect in thin Au films containing a monolayer of cobalt(II) terpyridine complexes by altering the ligand structure around the Co2+ ions by depositing a thin Au capping layer on top of the monolayer on Au by magnetron sputtering (more energetic) and e-beam

  20. Probing the quenching of CdSe/ZnS qdots by Au, Au/Ag, and Au/Pd nanoparticles.

    Science.gov (United States)

    Han, Hyunjoo; Valle, Valerie; Maye, Mathew M

    2012-11-02

    The resonance energy transfer between CdSe/ZnS quantum dots (qdots) and three metallic nanoparticles (NPs) with different surface plasmon resonance (SPR) characteristics were studied. Gold, gold/silver and gold/palladium NPs were used as energy acceptors for qdots with donor emission at 570 nm. Due to the different spectral overlaps between the SPR signatures and qdot emission, varied energy transfer characteristics were observed. The energy transfer was quantified via the Stern-Volmer relationship, since in this study the energy transfer was collision based. The Au/Ag and Au/Pd NPs in particular showed high K(SV) values, while the Au NPs showed much lower energy transfer efficiency. Since the NPs used in this study were relatively large (d ~ 15-20 nm), the experimental system was also influenced by the NP extinction coefficients of ≈10(8) M(-1) cm(-1). To address this potential inner filter effect, the quenching profiles were normalized by SPR transmittance. The results are important to the field, as many of these classes of nanomaterials are being employed in energy transfer based studies, as well as in colorimetric sensing.

  1. Di-hadron correlations with identified leading hadrons in 200 GeV Au + Au and d + Au collisions at STAR

    Energy Technology Data Exchange (ETDEWEB)

    Adamczyk, L. [AGH University of Science and Technology, Cracow 30-059 (Poland); Adkins, J.K. [University of Kentucky, Lexington, KY, 40506-0055 (United States); Agakishiev, G. [Joint Institute for Nuclear Research, Dubna, 141 980 (Russian Federation); Aggarwal, M.M. [Panjab University, Chandigarh 160014 (India); Ahammed, Z. [Variable Energy Cyclotron Centre, Kolkata 700064 (India); Alekseev, I. [Alikhanov Institute for Theoretical and Experimental Physics, Moscow 117218 (Russian Federation); Aparin, A. [Joint Institute for Nuclear Research, Dubna, 141 980 (Russian Federation); Arkhipkin, D.; Aschenauer, E.C. [Brookhaven National Laboratory, Upton, NY 11973 (United States); Averichev, G.S. [Joint Institute for Nuclear Research, Dubna, 141 980 (Russian Federation); Bai, X. [University of Illinois at Chicago, Chicago, IL 60607 (United States); Bairathi, V. [National Institute of Science Education and Research, Bhubaneswar 751005 (India); Banerjee, A. [Variable Energy Cyclotron Centre, Kolkata 700064 (India); Bellwied, R. [University of Houston, Houston, TX 77204 (United States); Bhasin, A. [University of Jammu, Jammu 180001 (India); Bhati, A.K. [Panjab University, Chandigarh 160014 (India); Bhattarai, P. [University of Texas, Austin, TX 78712 (United States); Bielcik, J. [Czech Technical University in Prague, FNSPE, Prague, 115 19 (Czech Republic); Bielcikova, J. [Nuclear Physics Institute AS CR, 250 68 Řež/Prague (Czech Republic); Bland, L.C. [Brookhaven National Laboratory, Upton, NY 11973 (United States); and others

    2015-12-17

    The STAR Collaboration presents for the first time two-dimensional di-hadron correlations with identified leading hadrons in 200 GeV central Au + Au and minimum-bias d + Au collisions to explore hadronization mechanisms in the quark gluon plasma. The enhancement of the jet-like yield for leading pions in Au + Au data with respect to the d + Au reference and the absence of such an enhancement for leading non-pions (protons and kaons) are discussed within the context of a quark recombination scenario. The correlated yield at large angles, specifically in the ridge region, is found to be significantly higher for leading non-pions than pions. The consistencies of the constituent quark scaling, azimuthal harmonic model and a mini-jet modification model description of the data are tested, providing further constraints on hadronization.

  2. Di-hadron correlations with identified leading hadrons in 200 GeV Au+Au and d+Au collisions at STAR

    Directory of Open Access Journals (Sweden)

    L. Adamczyk

    2015-12-01

    Full Text Available The STAR Collaboration presents for the first time two-dimensional di-hadron correlations with identified leading hadrons in 200 GeV central Au+Au and minimum-bias d+Au collisions to explore hadronization mechanisms in the quark gluon plasma. The enhancement of the jet-like yield for leading pions in Au+Au data with respect to the d+Au reference and the absence of such an enhancement for leading non-pions (protons and kaons are discussed within the context of a quark recombination scenario. The correlated yield at large angles, specifically in the ridge region, is found to be significantly higher for leading non-pions than pions. The consistencies of the constituent quark scaling, azimuthal harmonic model and a mini-jet modification model description of the data are tested, providing further constraints on hadronization.

  3. Di-hadron correlations with identified leading hadrons in 200 GeV Au + Au and d + Au collisions at STAR

    Energy Technology Data Exchange (ETDEWEB)

    Adamczyk, L; Adkins, JK; Agakishiev, G; Aggarwal, MM; Ahammed, Z; Alekseev, I; Aparin, A; Arkhipkin, D; Aschenauer, EC; Averichev, GS; Bai, X; Bairathi, V; Banerjee, A; Bellwied, R; Bhasin, A; Bhati, AK; Bhattarai, P; Bielcik, J; Bielcikova, J; Bland, LC; Bordyuzhin, IG; Bouchet, J; Brandenburg, D; Brandin, AV; Bunzarov, I; Butterworth, J; Caines, H; Calderón de la Barca Sánchez, M; Campbell, JM; Cebra, D; Cervantes, MC; Chakaberia, I; Chaloupka, P; Chang, Z; Chattopadhyay, S; Chen, X; Chen, JH; Cheng, J; Cherney, M; Christie, W; Contin, G; Crawford, HJ; Das, S; De Silva, LC; Debbe, RR; Dedovich, TG; Deng, J; Derevschikov, AA; di Ruzza, B; Didenko, L; Dilks, C; Dong, X; Drachenberg, JL; Draper, JE; Du, CM; Dunkelberger, LE; Dunlop, JC; Efimov, LG; Engelage, J; Eppley, G; Esha, R; Evdokimov, O; Eyser, O; Fatemi, R; Fazio, S; Federic, P; Fedorisin, J; Feng, Z; Filip, P; Fisyak, Y; Flores, CE; Fulek, L; Gagliardi, CA; Garand, D; Geurts, F; Gibson, A; Girard, M; Greiner, L; Grosnick, D; Gunarathne, DS; Guo, Y; Gupta, S; Gupta, A; Guryn, W; Hamad, A; Hamed, A; Haque, R; Harris, JW; He, L; Heppelmann, S; Heppelmann, S; Hirsch, A; Hoffmann, GW; Hofman, DJ; Horvat, S; Huang, T; Huang, B; Huang, HZ; Huang, X; Huck, P

    2015-10-23

    The STAR Collaboration presents for the first time two-dimensional di-hadron correlations with identified leading hadrons in 200 GeV central Au + Au and minimum-bias d + Au collisions to explore hadronization mechanisms in the quark gluon plasma. The enhancement of the jet-like yield for leading pions in Au + Au data with respect to the d + Au reference and the absence of such an enhancement for leading non-pions (protons and kaons) are discussed within the context of a quark recombination scenario. The correlated yield at large angles, specifically in the ridge region, is found to be significantly higher for leading non-pions than pions. The consistencies of the constituent quark scaling, azimuthal harmonic model and a mini-jet modification model description of the data are tested, providing further constraints on hadronization.

  4. THE VALENCE OF AU IN AUTE2 AND AUSE STUDIED BY X-RAY-ABSORPTION SPECTROSCOPY

    NARCIS (Netherlands)

    ETTEMA, ARHF; STEGINK, TA; HAAS, C

    The gold compounds AuTe2 and AuSe contain Au atoms in two different chemical surroundings. In the literature these different coordinations have been associated with a difference in valency of the Au atoms. In this paper the occupation of the 5d shell in AuSe and AuTe2 is deduced from a study of the

  5. Thermal desorption of Au from W(001) surface

    CERN Document Server

    Blaszczyszyn, R; Godowski, P J

    2002-01-01

    Adsorption of Au on W(001) at 450 K up to multilayer structures was investigated. Temperature programmed desorption technique was used in determination of coverage dependent desorption energy (region up to one monolayer). Results were discussed in terms of competitive interactions of Au-Au and Au-W atoms. Simple procedure for prediction of faceting behavior on the interface, basing on the desorption data, was postulated. It was deduced that the Au/W(001) interface should not show faceting tendency after thermal treatment. (author)

  6. [Hyp-Au-Sn9(Hyp)3-Au-Sn9(Hyp)3-Au-Hyp]-: the longest intermetalloid chain compound of tin.

    Science.gov (United States)

    Binder, Mareike; Schrenk, Claudio; Block, Theresa; Pöttgen, Rainer; Schnepf, Andreas

    2017-10-12

    The reaction of the metalloid tin cluster [Sn10(Hyp)4]2- with (Ph3P)Au-SHyp (Hyp = Si(SiMe3)3) gave an intermetalloid cluster [Au3Sn18(Hyp)8]-1, which is the longest intermetalloid chain compound of tin to date. 1 shows a structural resemblance to binary AuSn phases, which is expected for intermetalloid clusters.

  7. Photoswitchable Faraday effect in EuS-Au nanosystems

    Energy Technology Data Exchange (ETDEWEB)

    Kawashima, Akira; Nakanishi, Takayuki; Kitagawa, Yuichi; Fushimi, Koji; Hasegawa, Yasuchika [Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, North-13 West-8, Kita-ku, 060-8628, Sapporo (Japan)

    2016-01-15

    Effective photoswitchable europium sulfide nanocrystals with gold nanoparticles using dithiol (DDT: 1,10-decanedithiol) joint molecules, EuS-Au nanosystems, are demonstrated. The TEM image indicates the formation of EuS-Au nanosystems composed of cube-shaped EuS nanocrystals and spherical Au nanoparticles. Under visible-light irradiation, a drastic change of absorption band of EuS-Au nanosystems at around 600 nm was observed. The Faraday effects of EuS-Au nanosystems were estimated using magnetic circular dichroism (MCD) measurements. The effective change of the MCD spectra of EuS-Au nanosystems under visible-light irradiation was successfully observed at around 670 nm for the first time. The effective reversible changes in MCD spectra with the alternative irradiation cycles of visible light (>440 nm) and dark are also presented. The decrease rate of rotation angle at 670 nm of EuS-Au nanosystems is larger than that of absorbance. These results indicate that the effective change of MCD spectra of EuS-Au nanosystems would be dominated not only by a drastic change of absorption band related to enhanced LSPR of Au nanoparticles but also by specific interaction between EuS and Au in nanosystem under irradiation. Illustration of photoswitch and TEM image of EuS-Au nanosystems. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  8. Introduction au numéro

    Directory of Open Access Journals (Sweden)

    Diane-Gabrielle Tremblay

    2005-07-01

    Full Text Available Depuis quelques années, le thème de l’économie sociale fait couler beaucoup d’encre au Québec, comme ailleurs. Ce numéro présente un bilan de l’économie sociale au Québec, coordonné par Jean-Marc Fontan et Denis Bussières. Toutefois, afin d’avoir un portrait plus global et une perspective théorique sur la question, Interventions économiques a sollicité un texte de Jacques Defourny, afin de compléter le dossier. En effet, l’économie sociale, les secteurs non-marchands, les services de proximi...

  9. Le fonds Gabriel Tarde au CHEVS

    OpenAIRE

    Louise Salmon

    2016-01-01

    Le fonds d’archives « Gabriel Tarde » déposé au CHEVS nous permet de mieux saisir l’érudit autodidacte que fut Gabriel Tarde. De la genèse de sa pensée à ses réseaux de sociabilité, de l’homme de sciences à l’homme de lettres, ses archives témoignent à la fois des usages et des enjeux des ressources archivistiques en histoire, mais elles permettent surtout un renouvellement du regard sur Gabriel Tarde en l’inscrivant au cœur de son temps que fut la fin du XIXème siècle.At the CHEVS in Paris, ...

  10. Identification of sup 186 Au. alpha. activity

    Energy Technology Data Exchange (ETDEWEB)

    Akovali, Y.A.; Toth, K.S. (Oak Ridge National Laboratory, Oak Ridge, TN (USA)); Bingham, C.R. (University of Tennessee, Knoxville, TN (USA) Oak Ridge National Laboratory, Oak Ridge, TN (USA)); Kassim, M.B.; Zhang, M. (University of Tennessee, Knoxville, TN (USA)); Carter, H.K. (UNISOR, Oak Ridge Associated Universities, Oak Ridge, TN (USA)); Hamilton, W.D. (Joint Institute for Heavy Ion Research, Holifield Heavy Ion Research Facility, Oak Ridge, TN (USA) Vanderbilt University, Nashville, TN (USA)); Kormicki, J. (Vanderbilt University, Nashville, TN (USA))

    1990-09-01

    With the use of an on-line isotope separator, the {alpha} activity of {sup 186}Au was identified for the first time. Only one {alpha} group ({ital E}{sub {alpha}}=4653{plus minus}15 keV) was observed. This transition was found not to be in coincidence with {gamma} rays so that it probably proceeds either to the {sup 182}Ir ground state or to a low-lying level whose deexciting {gamma} rays could not be detected. The {alpha}-decay branching was determined to be (8{plus minus}2){times}10{sup {minus}4}% from which a hindrance factor of 1.9{plus minus}0.9 was deduced. The 4653-keV {alpha} transition must therefore connect the 3{sup {minus}} {sup 186}Au ground state with a {sup 182}Ir level with the same spin and configuration.

  11. Au Based Nanocomposites Towards Plasmonic Applications

    Science.gov (United States)

    Panniello, A.; Curri, M. L.; Placido, T.; Reboud, V.; Kehagias, N.; Sotomayor Torres, C. M.; Mecerreyes, D.; Agostiano, A.; Striccoli, M.

    2010-06-01

    Incorporation of nano-sized metals in polymers can transfer their unique features to the host matrix, providing nanocomposite materials with improved optical, electric, magnetic and mechanical properties. In this work, colloidal Au nanorods have been incorporated into PMMA based random co-polymer, properly functionalized with amino groups and the optical and morphological properties of the resulting nanocomposite have been investigated by spectroscopic and AFM measurements. Au nanorods have demonstrated to preserve the plasmon absorption and to retain morphological features upon the incorporation, thus making the final metal modified polymer composite exploitable for the fabrication of plasmonic devices. The prepared nanocomposites have been then patterned by Nano Imprint Lithography technique in order to demonstrate the viability of the materials towards optical applications.

  12. Near-infrared-responsive, superparamagnetic Au@Co nanochains

    Directory of Open Access Journals (Sweden)

    Varadee Vittur

    2017-08-01

    Full Text Available This manuscript describes a new type of nanomaterial, namely superparamagnetic Au@Co nanochains with optical extinctions in the near infrared (NIR. The Au@Co nanochains were synthesized via a one-pot galvanic replacement route involving a redox-transmetalation process in aqueous medium, where Au salt was reduced to form Au shells on Co seed templates, affording hollow Au@Co nanochains. The Au shells serve not only as a protective coating for the Co nanochain cores, but also to give rise to the optical properties of these unique nanostructures. Importantly, these bifunctional, magneto-optical Au@Co nanochains combine the advantages of nanophotonics (extinction at ca. 900 nm and nanomagnetism (superparamagnetism and provide a potentially useful new nanoarchitecture for biomedical or catalytic applications that can benefit from both activation by light and manipulation using an external magnetic field.

  13. Tuning the collective switching behavior of azobenzene/Au hybrid materials: flexible versus rigid azobenzene backbones and Au(111) surfaces versus curved Au nanoparticles.

    Science.gov (United States)

    Liu, Chunyan; Zheng, Dong; Hu, Weigang; Zhu, Qiang; Tian, Ziqi; Zhao, Jun; Zhu, Yan; Ma, Jing

    2017-11-09

    The combination of photo-responsive azobenzene (AB) and biocompatible Au nanomaterials possesses potential applications in diverse fields such as biosensing and thermotherapy. To explore the influence of azobenzene moieties and Au substrates on the collective switching behavior, two different azobenzene derivatives (rigid biphenyl-controlled versus flexible alkoxyl chain-linked) and three different Au substrates (a planar Au(111) surface, curved Au 102 (SR) 44 and Au 25 (SR) 18 clusters) were chosen to form six Au@AB combinations. A reactive molecular dynamics (RMD) model considering both the torsion and inversion path was implemented to simulate the collective photo-induced cis-to-trans switching process of AB monolayers on Au substrates. The major driving force for isomerization is demonstrated to be the torsion of the C-N[double bond, length as m-dash]N-C dihedral angle, in addition to the minor contribution from an inversion pathway. The isomerization process can be divided into the preliminary conformation switching stage and the later relaxation stage, in which a gradual self-organization is observed for 40 ps. The Au substrate affects the packing structure of the AB monolayer, while the choice of different kinds of ABs tunes the intermolecular interaction in the monolayer. Flexible alkoxyl-linked F-AB may achieve much faster conversion on Au clusters than on the surface. For rigid biphenyl-based R-AB anchored on Au nanoparticles (AuNPs), a competitive torsion between the biphenyl and C-N[double bond, length as m-dash]N-C dihedral may delay the C-N[double bond, length as m-dash]N-C dihedral torsion and the following isomerization process. After the R-AB molecules were anchored on the Au(111) surface, the strong π-π stacking between biphenyl units accelerates the collective isomerization process. A curvature-dependent effect is observed for R-AB SAMs on different-sized substrates. The cooperation between functional AB monolayers and the Au substrate

  14. Biorelevant in vitro performance testing of orally administered dosage forms-workshop report.

    Science.gov (United States)

    Reppas, Christos; Friedel, Horst-Dieter; Barker, Amy R; Buhse, Lucinda F; Cecil, Todd L; Keitel, Susanne; Kraemer, Johannes; Morris, J Michael; Shah, Vinod P; Stickelmeyer, Mary P; Yomota, Chikako; Brown, Cynthia K

    2014-07-01

    Biorelevant in vitro performance testing of orally administered dosage forms has become an important tool for the assessment of drug product in vivo behavior. An in vitro performance test which mimics the intraluminal performance of an oral dosage form is termed biorelevant. Biorelevant tests have been utilized to decrease the number of in vivo studies required during the drug development process and to mitigate the risk related to in vivo bioequivalence studies. This report reviews the ability of current in vitro performance tests to predict in vivo performance and generate successful in vitro and in vivo correlations for oral dosage forms. It also summarizes efforts to improve the predictability of biorelevant tests. The report is based on the presentations at the 2013 workshop, Biorelevant In Vitro Performance Testing of Orally Administered Dosage Forms, in Washington, DC, sponsored by the FIP Dissolution/Drug Release Focus Group in partnership with the American Association of Pharmaceutical Scientists (AAPS) and a symposium at the AAPS 2012 Annual meeting on the same topic.

  15. Differentiation in the Amsterdam methadone dispensing circuit: determinants of methadone dosage and site of methadone prescription

    NARCIS (Netherlands)

    Langendam, M. W.; van Haastrecht, H. J.; van Brussel, G. H.; Reurs, H.; van den Hoek, A. A.; Coutinho, R. A.; van Ameijden, E. J.

    1998-01-01

    To evaluate the Methadone Dispensing Circuit in Amsterdam by identifying determinants of methadone dosage and client characteristics in the different types of methadone programmes. Four hundred and forty-four participants of a cohort study of drug users in Amsterdam who had consented to link data of

  16. Influence de la nature et du dosage en fibres sur le comportement ...

    African Journals Online (AJOL)

    Influence de la nature et du dosage en fibres sur le comportement physico- mécanique des bétons de sable à base de fillers de laitier granulé. Influence of fiber type and volume contents on the physical and mechanical behaviour of sandcrete with blast furnace slag fillers. Saloua Melais*, Fatma Zohra Melais & Djamel ...

  17. Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Enalapril.

    NARCIS (Netherlands)

    Verbeeck, Roger K; Kanfer, Isadore; Löbenberg, Raimar; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Langguth, Peter; Polli, James E; Parr, Alan; Shah, Vinod P; Mehta, Mehul; Dressman, Jennifer B

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence testing for the marketing authorization of immediate-release, solid oral dosage forms containing enalapril maleate are reviewed. Enalapril, a prodrug, is hydrolyzed by carboxylesterases to the active

  18. Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

    NARCIS (Netherlands)

    Thambavita, Dhanusha; Galappatthy, Priyadarshani; Mannapperuma, Uthpali; Jayakody, Lal; Cristofoletti, Rodrigo; Abrahamsson, Bertil; Groot, Dirk W; Langguth, Peter; Mehta, Mehul; Parr, Alan; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2017-01-01

    Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System

  19. Gene-dosage effects in Down syndrome and trisomic mouse models

    OpenAIRE

    Gardiner, Katheleen

    2004-01-01

    The abnormalities found in human Down syndrome (trisomy 21) have been thought to result from increased expression of genes on chromosome 21 because of their higher gene dosage. Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions were found.

  20. In-vitro Characterization of Optimized Multi-Unit Dosage Forms of ...

    African Journals Online (AJOL)

    Michael Horsfall

    In-vitro Characterization of Optimized Multi-Unit Dosage Forms of Theophylline and its Solid State Characterisation. *1UHUMWANGHO, M U; 2RAMANA, MURTHY K V. 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria. 2University College of Pharmaceutical ...

  1. Enoxaparin, effective dosage for intensive care patients: double-blinded, randomised clinical trial

    DEFF Research Database (Denmark)

    Robinson, Sian; Zincuk, Aleksander; Strøm, Thomas

    2010-01-01

    that a standard dose of 40 mg enoxaparin yielded subtherapeutic levels of aFXa in critically ill patients. Higher doses resulted in better peak aFXa levels, with a ceiling effect observed at 60 mg. The present study seems to suggest inadequate dosage as one of the possible mechanisms for the higher failure rate...

  2. Effect of low dosages of powdered activated carbon on membrane bioreactor performance

    NARCIS (Netherlands)

    Remy, M.J.J.; Temmink, H.; Rulkens, W.H.

    2012-01-01

    Previous research has demonstrated that powdered activated carbon (PAC), when applied at very low dosages and long SRTs, reduces membrane fouling in membrane bioreactors (MBRs). This effect was related to the formation of stronger sludge flocs, which are less sensitive to shear. In this contribution

  3. The synchronisation of oestrus in sheep. 1. Dosage and time of ...

    African Journals Online (AJOL)

    The synchronisation of oestrus in sheep. 1. Dosage and time of prostaglandin administration following progestagen pretreatment. J.P.C. Greyling, J.M. van der Westhuysen, C.H. van Niekerk. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL ...

  4. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

    DEFF Research Database (Denmark)

    Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H

    2015-01-01

    of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites. Moreover, increased Rrm2 gene dosage significantly extends the life span of ATR mutant mice. Our study reveals the first genetic condition in mammals that reduces fragile...

  5. Minimum effective dosages of anti-TNF in rheumatoid arthritis: a cross-sectional study.

    Science.gov (United States)

    de la Torre, Inmaculada; Valor, Lara; Nieto, Juan Carlos; Montoro, María; Carreño, Luis

    2014-01-01

    To evaluate the modified dosages of anti-TNF in controlling disease activity in rheumatoid arthritis (RA) measured by DAS28-ESR. Cross-sectional study: RA patients treated with etanercept (ETN), adalimumab (ADA) or infliximab (IFX), at standard or modified doses. dosage, concomitant disease modifying drugs (DMARDs), DAS28-ESR. 195 RA patients included (79% women, mean age 58.1 years): ETN=81, ADA=56, IFX=58. Mean disease duration and time to first biological treatment was higher in IFX group (P=.01). Patients distribution by dosage: standard: ETN (72.8%), ADA (69.6%), IFX (27.6%); escalated: IFX (69%), ADA (5.4%), ETN (0%); reduced: ETN (27.1%), ADA (25%), IFX (3.4%). Concomitant DMARDs use was lower in ETN (58.2%) than ADA (66.07%) and IFX (79.31%). Higher proportion of responders (DAS28 ≤3.2) in ADA (65.3%) and ETN (61.7%) than IFX (48.3%). RA clinical control can be preserved with modified anti-TNF dosages. Controlled prospective studies should be performed to define when therapy can be tailored and for which patients. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  6. Therapeutic drug monitoring : how to improve drug dosage and patient safety in tuberculosis treatment

    NARCIS (Netherlands)

    Sotgiu, Giovanni; Alffenaar, Jan-Willem C.; Centis, Rosella; D'Ambrosio, Lia; Spanevello, Antonio; Piana, Andrea; Migliori, Giovanni Battista

    In this article we describe the key role of tuberculosis (TB) treatment, the challenges (mainly the emergence of drug resistance), and the opportunities represented by the correct approach to drug dosage, based on the existing control and elimination strategies. In this context, the role and

  7. 76 FR 40229 - Oral Dosage Form New Animal Drugs; Change of Sponsor

    Science.gov (United States)

    2011-07-08

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 520 Oral Dosage Form New Animal Drugs; Change of Sponsor AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug... application (NADA) from Virbac AH, Inc., to Cross Vetpharm Group Ltd. DATES: This rule is effective July 8...

  8. The effect of different dosages of caffeine on endurance performance time

    NARCIS (Netherlands)

    Pasman, W.J.; Baak, M.A. van; Jeukendrup, A.E.; Haan, A. de

    1995-01-01

    The effect of different dosages of caffeine (0 - 5 - 9 - 13 mg · kg body weight-1) on endurance performance was examined. Nine well-trained cyclists participated in this study (VO2max 65.1 + 2.6 ml · kg-1 · min-1). Caffeine capsules were administered in random order and double-blind. One hour after

  9. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in ...

    Indian Academy of Sciences (India)

    SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes. Michele Salemi Corrado Romano Concetta Barone Francesco Calí Filippo Caraci Carmelo Romano Cataldo Scavuzzo Francesco Scillato Maria Grazia Salluzzo Maria Piccione Manuela Martines Giovanni ...

  10. 76 FR 12563 - Oral Dosage Form New Animal Drugs; Spinosad and Milbemycin Oxime

    Science.gov (United States)

    2011-03-08

    ... Center for Veterinary Medicine, 21 CFR part 520 is amended as follows: PART 520--ORAL DOSAGE FORM NEW... animal drug application (NADA) filed by Elanco Animal Health. The NADA provides for veterinary... prevention of flea infestations and for the prevention and control of various internal parasites. DATES: This...

  11. Visual field loss associated with vigabatrin : Quantification and relation to dosage

    NARCIS (Netherlands)

    Hardus, P; Verduin, WM; Engelsman, M; Edelbroek, PM; Segers, JP; Berendschot, TTJM; Stilma, JS

    Purpose: To describe the correlation between visual field loss and the duration, dosage. and total amount of vigabatrin (VGB) medication in a group of patients with epilepsy. Co-medication of antiepileptic drugs (AEDs) and compliance were also studied. Methods: Ninety-two patients (53 male and 39

  12. LABORATORY PROTECTION RATE OF TORN BEDNETS TREATED WITH THREE DOSAGES OF PYRETHROIDE AGAINST ANOPHELES CULICIFACIES

    Directory of Open Access Journals (Sweden)

    G. Babaee

    2007-05-01

    Full Text Available Evaluated under laboratory condition. The objective of the present study was to observe the effect of impregnated torn bednets on the number of bites by An. culicifacies A glass made tunnel test was designed to The effect of torn bednets treated with three dosages of cyfluthrin 5% EW, were induce hungry female mosquitoes to pass through holes cut in the pyrethroid treated nets. A guinea pig used as bait to attract mosquitoes through circular holes in the netting. With untreated netting, 72-87% of laboratory-reared females passed through the holes overnight, 64-92% blood-fed successfully and 0.3/9-4/3% died. When the netting was treated with cyfluthrin at doses of 25, 50 and 100 mg a.i./m2, the entry Index (the proportions that passed through the holes overnight were 43.37%, 42.82% and 24.72%; mortality rates were 66.31%, 81.45% and 95.99%; and the feeding rate were 45%, 27% and 3%. In conclusion it should be stressed that efficacy of pyrethroid impregnated bednets using “Tunnel Tests” showing acceptable protection rate both in lower and higher dosages as well as cause dead in the blood-fed mosquitoes. In addition, the higher dosages of these three dosages pyrethroid provided good levels of protection against An. culicifacies.

  13. Miniaturized approach for excipient selection during the development of oral solid dosage form

    DEFF Research Database (Denmark)

    Raijada, Dharaben Kaushikkumar; Müllertz, Anette; Cornett, Claus

    2014-01-01

    The present study introduces a miniaturized high-throughput platform to understand the influence of excipients on the performance of oral solid dosage forms during early drug development. Wet massing of binary mixtures of the model drug (sodium naproxen) and representative excipients was followed...

  14. Les entreprises au Royaume-Uni

    OpenAIRE

    Appay, Beatrice

    1987-01-01

    This chapter of the book "Formations et emplois qualifiés. Les transformations dans le Bâtiment en France et au Royaume-Uni" analyses management strategies and organisational changes during a period of continuous crisis. The concept of cascading subcontracting (sous-traitance en cascade) introduced here encapsulates a new phenomenon observed simultaneously in the ever changing organisation of work between and within the firms. This is an important result of a research based on a 34 firm monog...

  15. la lutte contre le SIDA au Cameroun

    African Journals Online (AJOL)

    Chantel

    plurielles'). Tsala Tsala, J.-Ph. (2001). Medicina tradicional y sistema de salud publica en Camerun. Siso/Saude. 35: 48 -57. UNICEF, ONUSIDA, OMS (2001). Suivi et évaluation (au niveau local) de la prévention intégrée de la transmission mère-enfant du VIH dans les pays à revenus faibles.(doc ined. Projet 03/2001). 156.

  16. Le CRDI au Népal

    International Development Research Centre (IDRC) Digital Library (Canada)

    et visant à évaluer et à faire connaître les innovations en matière de production agricole, de transformation et de mise en marché. Le CRDI collabore avec le Fonds international de développement agricole à la mise sur pied de ce réseau, dont les membres sont reliés au moyen de technologies numériques. TE. K. G. U. R.

  17. Interstellar Pickup Ion Observations to 38 au

    Science.gov (United States)

    McComas, D. J.; Zirnstein, E. J.; Bzowski, M.; Elliott, H. A.; Randol, B.; Schwadron, N. A.; Sokół, J. M.; Szalay, J. R.; Olkin, C.; Spencer, J.; Stern, A.; Weaver, H.

    2017-11-01

    We provide the first direct observations of interstellar H+ and He+ pickup ions in the solar wind from 22 to 38 au. We use the Vasyliunas and Siscoe model functional form to quantify the pickup ion distributions, and while the fit parameters generally lie outside their physically expected ranges, this form allows fits that quantify variations in the pickup H+ properties with distance. By ∼20 au, the pickup ions already provide the dominant internal pressure in the solar wind. We determine the radial trends and extrapolate them to the termination shock at ∼90 au, where the pickup H+ to core solar wind density reaches ∼0.14. The pickup H+ temperature and thermal pressure increase from 22 to 38 au, indicating additional heating of the pickup ions. This produces very large extrapolated ratios of pickup H+ to solar wind temperature and pressure, and an extrapolated ratio of the pickup ion pressure to the solar wind dynamic pressure at the termination shock of ∼0.16. Such a large ratio has profound implications for moderating the termination shock and the overall outer heliospheric interaction. We also identify suprathermal tails in the H+ spectra and complex features in the He+ spectra, likely indicating variations in the pickup ion history and processing. Finally, we discover enhancements in both H+ and He+ populations just below their cutoff energies, which may be associated with enhanced local pickup. This study serves to document the release and serves as a citable reference of these pickup ion data for broad community use and analysis.

  18. A ternary functional Ag@GO@Au sandwiched hybrid as an ultrasensitive and stable surface enhanced Raman scattering platform

    Science.gov (United States)

    Zhang, Cong-yun; Hao, Rui; Zhao, Bin; Hao, Yao-wu; Liu, Ya-qing

    2017-07-01

    The graphene-mediated surface enhanced Raman scattering (SERS) substrates by virtues of plasmonic metal nanostructures and graphene or its derivatives have attracted tremendous interests which are expected to make up the deficiency of traditional plasmonic metal substrates. Herein, we designed and fabricated a novel ternary Ag@GO@Au sandwich hybrid wherein the ultrathin graphene oxide (GO) films were seamlessly wrapped around the hierarchical flower-like Ag particle core and meanwhile provided two-dimensional anchoring scaffold for the coating of Au nanoparticles (NPs). The surface coverage density of loading Au NPs could be readily controlled by tuning the dosage amount of Au particle solutions. These features endowed the sandwiched structures high enrichment capability for analytes such as aromatic molecules and astonishing SERS performance. The Raman signals were enormously enhanced with an ultrasensitive detection limit of rhodamine-6G (R6G) as low as 10-13 M based on the chemical enhancement from GO and multi-dimensional plasmonic coupling between the metal nanoparticles. In addition, the GO interlayer as an isolating shell could effectively prevent the metal-molecule direct interaction and suppress the oxidation of Ag after exposure at ambient condition which enabled the substrates excellent reproducibility with less than 6% signal variations and prolonged life-time. To evaluate the feasibility and the practical application for SERS detection in real-world samples based on GO sandwiched hybrid as SERS-active substrate, three different prohibited colorants with a series of concentrations were measured with a minimum detected concentration down to 10-9 M. Furthermore, the prepared GO sandwiched nanostructures can be used to identify different types of colorants existing in red wine, implying the great potential applications for single-particle SERS sensing of biotechnology and on-site monitoring in food security.

  19. Functionalized Au@Ag-Au nanoparticles as an optical and SERS dual probe for lateral flow sensing.

    Science.gov (United States)

    Bai, Tingting; Wang, Meng; Cao, Min; Zhang, Juan; Zhang, Kangzhen; Zhou, Ping; Liu, Zhengxia; Liu, Ying; Guo, Zhirui; Lu, Xiang

    2018-02-14

    Lateral flow assay strips (LFASs) with Au nanoparticles (NPs) have been widely used as a probe for biomarkers in point-of-care testing; however, there still remain challenges in detection sensitivity and quantitative analysis. In this study, we developed a surface-enhanced Raman scattering (SERS)-based LFAS for quantitative analysis of a biomarker in the low concentration range. Moreover, apart from conventional Au NPs, three other types of citrate-capped Au-Ag bimetallic NPs: Au core with Ag shell NPs (Au@Ag NPs), rattle-like Au core in Ag-Au shell NPs (Au@Ag-Au NPs) and Ag-Au NPs were prepared and functionalized, and their solution-based SERS activities were comprehensively studied by experimental measurement and theoretical analysis. The results clearly indicated that the citrate-capped Au@Ag-Au NPs exhibited the highest SERS activity among the probes tested. Au@Ag-Au NPs were used as both optical and SERS probes in a SERS-based LFAS. In the presence of the analyte at high concentrations, a purple color appeared in the test zone. Highly sensitive and quantitative analysis was realized by measurement of SERS signals from the test lines. One of the most specific markers for cardiac injury, cardiac troponin I (cTnI), was chosen as the detection model. The detection limit of the SERS-based LFAS for cardiac troponin I was 0.09 ng/mL, lowered by nearly 50 times compared with visual results, and could be further lowered by optimization. These results demonstrated that the SERS-based LFAS using citrate-capped Au@Ag-Au NPs as probes can be a powerful tool for highly sensitive and quantitative detection of biomarkers. Graphical abstract A surface-enhanced Raman scattering (SERS)-based lateral flow assay strip using rattle-like Au core in Ag-Au shell (Au@Ag-Au) nanoparticles as probes was developed for quantitative analysis of a biomarker, with a detection limit nearly 50 times lower than that of visual assessment. C control line, T test line.

  20. A photoresponsive Au25 nanocluster protected by azobenzene derivative thiolates

    Science.gov (United States)

    Negishi, Yuichi; Kamimura, Ukyo; Ide, Mao; Hirayama, Michiyo

    2012-06-01

    An Au25 cluster protected by azobenzene derivative thiolates (S-Az) ([Au25(S-Az)18]-) was synthesized with the aim of producing a photoresponsive Au25 cluster. The matrix-assisted laser desorption/ionization mass spectrum of the product revealed that [Au25(S-Az)18]- was synthesized in high purity. Optical absorption spectra of [Au25(S-Az)18]- obtained before and after photoirradiation suggest that the azobenzenes in the ligands of Au25(S-Az)18 isomerize with an efficiency of nearly 100%, both from the trans to cis conformation and from the cis to trans conformation. Furthermore, the redox potential and optical absorption of Au25(S-Az)18 were found to change reversibly due to photoisomerization of azobenzenes.An Au25 cluster protected by azobenzene derivative thiolates (S-Az) ([Au25(S-Az)18]-) was synthesized with the aim of producing a photoresponsive Au25 cluster. The matrix-assisted laser desorption/ionization mass spectrum of the product revealed that [Au25(S-Az)18]- was synthesized in high purity. Optical absorption spectra of [Au25(S-Az)18]- obtained before and after photoirradiation suggest that the azobenzenes in the ligands of Au25(S-Az)18 isomerize with an efficiency of nearly 100%, both from the trans to cis conformation and from the cis to trans conformation. Furthermore, the redox potential and optical absorption of Au25(S-Az)18 were found to change reversibly due to photoisomerization of azobenzenes. Electronic supplementary information (ESI) available: Details of the experimental procedure and characterization of the products. See DOI: 10.1039/c2nr30830d

  1. Photocatalysis enhancement of Au/BFO nanoparticles using plasmon resonance of Au NPs

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yan; Cai, Zhongyang; Ma, Xueming, E-mail: xmma@phy.ecnu.edu.cn

    2015-12-15

    BiFeO{sub 3} (BFO) nanoparticles was synthesized via sol–gel technique, and successfully loaded with small sizes of gold nanoparticles (Au NPs) by impregnation-reduction method to extremely enhance the BFO photocatalytic activity. The obviously stronger optical absorption of Au/BFO observed from the UV–vis diffuse reflectance spectrum confirmed that the surface plasmon resonance (SPR) effect occured on the surface of Au NPs. And the surface plasmon-induced localized electric field could allow the formation of electron/hole pairs in the near surface region of BFO which can migrate to the surface without undergoing electron/hole (e{sup −}/h{sup +}) pair recombination. The more electrons and holes formed, the more ·OH will be generated to decompose the CR solution. When the gold loading in Au/BFO nanoparticles is 3.36 wt%, the obtained Au/BFO catalyst exhibits best photocatalytic activity evaluated by photocatalysis degradation of Congo red (CR) solution under the visible light irradiation.

  2. Unilateral brief-pulse electroconvulsive therapy and cognition: Effects of electrode placement, stimulus dosage and time.

    LENUS (Irish Health Repository)

    Semkovska, Maria

    2010-11-23

    To clarify advantages of unilateral electrode placement as an optimisation technique for electroconvulsive therapy (ECT) for depression, aims were to meta-analyse unilateral ECT effects on cognitive performance relative to: (1) bitemporal electrode placement, (2) electrical dosage, and (3) time interval between final treatment and cognitive reassessment. Relevant electronic databases were systematically searched through May 2009, using the terms: "electroconvulsive therapy" and ["cogniti∗", "neuropsycholog∗", "memory", "attention", "executive", "spatial", or "intellectual"]. Inclusion criteria were: independent study of depressed patients receiving unilateral or bitemporal brief-pulse ECT; within-subjects design; use of objective cognitive assessments; available mean electrical dosage for unilateral samples. Standardized pre-post ECT weighted effect sizes were computed and pooled within 16 cognitive domains by a mixed-effects model. Thirty-nine studies (1415 patients) were meta-analysed. Up to three days after final treatment, unilateral ECT was associated with significantly smaller decreases in global cognition, delayed verbal memory retrieval, and autobiographical memory, compared to bitemporal ECT. Significant publication bias was found for autobiographical memory, favouring reporting of larger percentage loss. Higher unilateral ECT electrical dosage predicted larger decreases in verbal learning, delayed verbal memory retrieval, visual recognition, and semantic memory retrieval. When retested more than three days after completing ECT, no significant differences remained between the two electrode placements; for unilateral ECT, electrical dosage no longer predicted cognitive performance whereas increasing interval between final treatment and retesting predicted growing improvement in some variables. This interval is a more useful long-term predictor of cognitive function than electrode placement or electrical dosage following unilateral ECT.

  3. Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes

    Directory of Open Access Journals (Sweden)

    Kultima Kim

    2007-09-01

    Full Text Available Abstract Background The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes, and between sex chromosomes and autosomes. In many organisms, dosage compensation has thus evolved to equalize sex-linked gene expression in males and females. In mammals this is achieved by X chromosome inactivation and in flies and worms by up- or down-regulation of X-linked expression, respectively. While otherwise widespread in systems with heteromorphic sex chromosomes, the case of dosage compensation in birds (males ZZ, females ZW remains an unsolved enigma. Results Here, we use a microarray approach to show that male chicken embryos generally express higher levels of Z-linked genes than female birds, both in soma and in gonads. The distribution of male-to-female fold-change values for Z chromosome genes is wide and has a mean of 1.4–1.6, which is consistent with absence of dosage compensation and sex-specific feedback regulation of gene expression at individual loci. Intriguingly, without global dosage compensation, the female chicken has significantly lower expression levels of Z-linked compared to autosomal genes, which is not the case in male birds. Conclusion The pronounced sex difference in gene expression is likely to contribute to sexual dimorphism among birds, and potentially has implication to avian sex determination. Importantly, this report, together with a recent study of sex-biased expression in somatic tissue of chicken, demonstrates the first example of an organism with a lack of global dosage compensation, providing an unexpected case of a viable system with large-scale imbalance in gene expression between sexes.

  4. Virus-templated Au and Au/Pt Core/shell Nanowires and Their Electrocatalytic Activitives for Fuel Cell Applications

    Science.gov (United States)

    LEE, YOUJIN; KIM, JUNHYUNG; YUN, DONG SOO; NAM, YOON SUNG; SHAO-HORN, YANG; BELCHER, ANGELA M.

    2014-01-01

    A facile synthetic route was developed to make Au nanowires (NWs) from surfactant-mediated bio-mineralization of a genetically engineered M13 phage with specific Au binding peptides. From the selective interaction between Au binding M13 phage and Au ions in aqueous solution, Au NWs with uniform diameter were synthesized at room temperature with yields greater than 98 % without the need for size selection. The diameters of Au NWs were controlled from 10 nm to 50 nm. The Au NWs were found to be active for electrocatalytic oxidation of CO molecules for all sizes, where the activity was highly dependent on the surface facets of Au NWs. This low-temperature high yield method of preparing Au NWs was further extended to the synthesis of Au/Pt core/shell NWs with controlled coverage of Pt shell layers. Electro-catalytic studies of ethanol oxidation with different Pt loading showed enhanced activity relative to a commercial supported Pt catalyst, indicative of the dual functionality of Pt for the ethanol oxidation and Au for the anti-poisoning component of Pt. These new one-dimensional noble metal NWs with controlled compositions could facilitate the design of new alloy materials with tunable properties. PMID:24910712

  5. Au 38 (SPh) 24 : Au 38 Protected with Aromatic Thiolate Ligands

    Energy Technology Data Exchange (ETDEWEB)

    Rambukwella, Milan; Burrage, Shayna; Neubrander, Marie; Baseggio, Oscar; Aprà, Edoardo; Stener, Mauro; Fortunelli, Alessandro; Dass, Amala

    2017-03-21

    Au38(SR)24 is one of the most extensively investigated gold nanomolecules along with Au25(SR)18 and Au144(SR)60. However, so far it has only been prepared using aliphatic-like ligands, where R = –SC6H13, -SC12H25 and –SCH2CH2Ph. Au38(SCH2CH2Ph)24 when reacted with HSPh undergoes core-size conversion to Au36(SPh)24, and existing literature suggest that Au38(SPh)24 cannot be synthesized. Here, contrary to prevailing knowledge, we demonstrate that Au38(SPh)24 can be prepared if the ligand exchanged conditions are optimized, without any formation of Au36(SPh)24. Conclusive evidence is presented in the form of MALDI-MS, ESI-MS characterization, and optical spectra of Au38(SPh)24 in a solid glass form showing distinct differences from that of Au38(S-aliphatic)24. Theoretical analysis confirms experimental assignment of the optical spectrum and shows that the stability of Au38(SPh)24 is comparable to that of its aliphatic analogues, but results from different physical origins, with a significant component of ligand-ligand attractive interactions.

  6. Assolement maraichage/heliciculture au Sud Benin

    Directory of Open Access Journals (Sweden)

    Assogba, F.

    1993-01-01

    Full Text Available In a system rotating vegetable crops/snail rearing, the effect of manure based on snail faeces on the productivity of lettuce has been studied in southern Benin, characterized by a guinea type climate and a degradated ferralitic soil commonly named as [alfisoil] "Terre de barre". The tested rotation system is an alternate biannual type where three forms of manure have been utilized : mineral manure (N15P15K15 ; organic manure (snail faeces or trashes ; combination of organic manure/mineral manure, that is snail faeces and N15P15K15. Five treatments were tested corresponding to the mode of manure which is either organic manure alone, or organic manure added with mineral manure applied at three levels : 0 g, 125 g, 250 g per plot of de 7.2 rrf. The results obtained showed a quite good plant developement for all treatments except on plots where only trashes were used. The highest yield in green salad (150 kg/100 rrf per plot on the average has been obtained on the plot where snails were reared in year 1 and where in year 2 an average dosage of mineral manure (125 g of N15P15K15 was applied. We can temporarily conclude that snail faeces, combined with an average dosage of chemical fertilizer would insure a good production of lettuce.

  7. Triggered release of model drug from AuNP-doped BSA nanocarriers in hair follicles using IRA radiation.

    Science.gov (United States)

    Lademann, J; Richter, H; Knorr, F; Patzelt, A; Darvin, M E; Rühl, E; Cheung, K Y; Lai, K K; Renneberg, R; Mak, W C

    2016-01-01

    Recent advances in the field of dermatotherapy have resulted in research efforts focusing on the use of particle-based drug delivery systems for the stimuli-responsive release of drugs in the skin and skin appendages, i.e. hair follicles and sebaceous glands. However, effective and innocuous trigger mechanisms which result in the release of the drugs from the nanocarriers upon reaching the target structures are still lacking. For the first time, the present study demonstrated the photo-activated release of the model drug fluorescein isothiocyanate (FITC) from topically applied gold nanoparticle-doped bovine serum albumin (AuNPs-doped BSA) particles (approx. 545nm) using water-filtered infrared A (IRA) radiation in the hair follicles of an ex vivo porcine skin model. The IRA radiation-induced plasmonic heating of the AuNPs results in the partial decomposition or opening of the albumin particles and release the model drug, while control particles without AuNPs show insignificant release. The results demonstrate the feasibility of using IRA radiation to induce release of encapsulated drugs from plasmonic nanocarriers for the targeting of follicular structures. However, the risk of radiation-induced skin damage subsequent to repeated applications of high infrared dosages may be significant. Future studies should aim at determining the suitability of lower infrared A dosages, such as for medical treatment regimens which may necessitate repeated exposure to therapeutics. Follicular targeting using nanocarriers is of increasing importance in the prophylaxis and treatment of dermatological or other diseases. For the first time, the present study demonstrated the photo-activated release of the model drug fluorescein isothiocyanate (FITC) from topically applied gold nanoparticle-doped bovine serum albumin (AuNPs-doped BSA) particles using water-filtered infrared A (IRA) radiation in the hair follicles of an ex vivo porcine skin model. The results demonstrate the feasibility

  8. [Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity].

    Science.gov (United States)

    Spasov, A A; Smirnova, L A; Grechko, O U; Raschenko, A I; Shtareva, D M; Anisimova, V A

    2015-01-01

    Pharmacokinetic properties of imidazobenzimidazole derivative compound RU-1205 were investigated after subcutaneous administration to rabbits as a substance and a dosage form (lyophilisates for injection) at a dose of 25 mg/kg. The lyophilisate was characterized by high values of the relative bioavailability. In tests, the "hot plate" and "vinegar cramps" the dosage form and the substance exhibited the same analgesic effect.

  9. Analysis of the dosage controversy in recess-resect and Faden surgery with the Robinson computer model of eye movements

    NARCIS (Netherlands)

    H.J. Simonsz (Huib); B. van Dijk (Bob)

    1987-01-01

    textabstractIn recess-resect surgery, the dosage depends on the preoperative angle of squint and on the ratio between squint-angle reduction and dosage that the surgeon has found in previous surgery. Recommendations pertaining to this ratio vary widely among authors. Some say a recession does more

  10. Immunogenicity of two different dosages (10 and 5 μg) of recombinant DNA hepatitis B vaccine in healthy neonates

    NARCIS (Netherlands)

    R. Del Cancho (R.); P.M. Grosheie (P.); M. Voogd-Schotanus (M.); W. Huisman (Willem); R.A. Heijtink; S.W. Schalm (Solko)

    1994-01-01

    textabstractThe immunogenicity of a half (5 μg) and a full (10 μg) dosage of recombinant DNA yeast-derived hepatitis B vaccine (HB-Vax-DNA) in healthy neonates was assessed in order to compare two candidate dosages of vaccine. After randomization 174 newborns of HBsAg-negative mothers entered the

  11. Au99(SPh)42 nanomolecules: aromatic thiolate ligand induced conversion of Au144(SCH2CH2Ph)60.

    Science.gov (United States)

    Nimmala, Praneeth Reddy; Dass, Amala

    2014-12-10

    A new aromatic thiolate protected gold nanomolecule Au99(SPh)42 has been synthesized by reacting the highly stable Au144(SCH2CH2Ph)60 with thiophenol, HSPh. The ubiquitous Au144(SR)60 is known for its high stability even at elevated temperature and in the presence of excess thiol. This report demonstrates for the first time the reactivity of the Au144(SCH2CH2Ph)60 with thiophenol to form a different 99-Au atom species. The resulting Au99(SPh)42 compound, however, is unreactive and highly stable in the presence of excess aromatic thiol. The molecular formula of the title compound is determined by high resolution electrospray mass spectrometry (ESI-MS) and confirmed by the preparation of the 99-atom nanomolecule using two ligands, namely, Au99(SPh)42 and Au99(SPh-OMe)42. This mass spectrometry study is an unprecedented advance in nanoparticle reaction monitoring, in studying the 144-atom to 99-atom size evolution at such high m/z (∼12k) and resolution. The optical and electrochemical properties of Au99(SPh)42 are reported. Other substituents on the phenyl group, HS-Ph-X, where X = -F, -CH3, -OCH3, also show the Au144 to Au99 core size conversion, suggesting minimal electronic effects for these substituents. Control experiments were conducted by reacting Au144(SCH2CH2Ph)60 with HS-(CH2)n-Ph (where n = 1 and 2), bulky ligands like adamantanethiol and cyclohexanethiol. It was observed that conversion of Au144 to Au99 occurs only when the phenyl group is directly attached to the thiol, suggesting that the formation of a 99-atom species is largely influenced by aromaticity of the ligand and less so on the bulkiness of the ligand.

  12. Charge transport through O-deficient Au-MgO-Au junctions

    KAUST Repository

    Fadlallah, M. M.

    2009-12-29

    Metal-oxide heterostructures have been attracting considerable attention in recent years due to various technological applications. We present results of electronic structure and transport calculations for the Au-MgO-Au (metal-insulator-metal) heterostructure based on density-functional theory and the nonequilibrium Green’s functions method. The dependence of the conductance of the heterostructure on the thickness of the MgO interlayer and the interface spacing is studied. In addition, we address the effects of O vacancies. We observe deviations from an exponentially suppressed conductance with growing interlayer thickness caused by Au-O chemical bonds. Electronic states tracing back to O vacancies can increase the conductance. Furthermore, this effect can be enhanced by enlarging the interface spacing as the vacancy induced Mg states are shifted toward the Fermi energy.

  13. Elliptic flow in Au+Au collisions at $\\sqrt{S_{NN}}$=130 GeV

    CERN Document Server

    Ackermann, K H; Adler, C; Ahammed, Z; Ahmad, S; Allgower, C; Amsbaugh, J; Anderson, M; Anderssen, E; Arnesen, H; Arnold, L; Averichev, G S; Baldwin, A R; Balewski, J T; Barannikova, O Yu; Barnby, L S; Baudot, J; Beddo, M E; Bekele, S; Belaga, V V; Bellwied, R; Bennett, S; Bercovitz, J; Berger, J; Betts, W; Bichsel, H; Bieser, F; Bland, L C; Bloomer, M A; Blyth, C O; Böhm, J; Bonner, B E; Bonnet, D; Bossingham, R R; Botlo, M; Boucham, A; Bouillo, N; Bouvier, S; Bradley, K; Brady, F P; Braithwaite, E S; Braithwaite, W; Brandin, A B; Brown, R L; Brugalette, G; Byrd, C; Caines, H; Calderón de la Barca-Sanchez, M; Cardenas, A; Carr, L; Carroll, J; Castillo, J; Caylor, B; Cebra, D; Chathopadhyay, S; Chen, M L; Chen, W; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Chrin, J; Christie, W; Coffin, J P; Conin, L; Consiglio, C; Cormier, T M; Cramer, J G; Crawford, H J; Danilov, V I; Dayton, D; De Mello, M; Deng, W S; Derevshchikov, A A; Dialinas, M; Díaz, H; De Young, P A; Didenko, L; Dimassimo, D; Dioguardi, J; Dominik, Wojciech; Drancourt, C; Draper, J E; Dunin, V B; Dunlop, J C; Eckardt, V; Edwards, W R; Efimov, L G; Eggert, T; Emelyanov, V I; Engelage, J; Eppley, G; Erazmus, B; Etkin, A; Fachini, P; Feliciano, C; Ferenc, D; Ferguson, M I; Fessler, H; Finch, E; Fine, V; Fisyak, Yu; Flierl, D; Flores, I; Foley, Kenneth J; Fritz, D; Gagunashvili, N D; Gans, J; Gazdzicki, M; Germain, M; Geurts, F J M; Ghazikhanian, V; Gojak, C; Grabski, J; Grachov, O A; Grau, M; Greiner, D E; Greiner, L; Grigoriev, V; Grosnick, D P; Gross, J; Guilloux, G; Gushin, E M; Hall, J; Hallman, T J; Hardtke, D; Harper, G; Harris, J W; He, P; Heffner, M; Heppelmann, S; Herston, T; Hill, D; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Howe, M; Huang, H Z; Humanic, T J; Hümmler, H; Hunt, W; Hunter, J; Igo, G; Ishihara, A; Ivanshin, Yu I; Jacobs, P; Jacobs, W W; Jacobson, S; Jared, R; Jensen, P; Johnson, I; Jones, P G; Judd, E; Kaneta, M; Kaplan, M; Keane, D; Kenney, V P; Khodinov, A; Klay, J L; Klein, S R; Klyachko, A A; Koehler, G; Konstantinov, A S; Kormilitsyne, V; Kotchenda, L; Kotov, I V; Kovalenko, A D; Krämer, M; Kravtsov, P; Krüger, K; Krupien, T; Kuczewski, P; Kühn, C E; Kunde, G J; Kunz, C L; Kutuev, R K; Kuznetsov, A A; Lakehal-Ayat, L; Lamont, M A C; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lebedev, A; LeCompte, T J; Leonhardt, W; Leontiev, V M; Leszczynski, P; Le Vine, M J; Li, Q; Li, Z; Liaw, C J; Lin, J; Lindenbaum, S J; Lindenstruth, V; Lindstrom, P J; Lisa, M A; Liu, H; Ljubicic, T; Llope, W J; Lo Curto, G; Long, H; Longacre, R S; López-Noriega, M; Lopiano, D; Love, W A; Lutz, Jean Robert; Lynn, D; Madansky, L; Maier, R S; Majka, R; Maliszewski, A; Margetis, S; Marks, K; Marstaller, R; Martin, L; Marx, J; Matis, H S; Matulenko, Yu A; Matyushevsky, E A; McParland, C P; McShane, T S; Meier, J; Melnik, Yu M; Meshchanin, A P; Middlekamp, P; Mikhalin, N; Miller, B; Milosevich, Z; Minaev, N G; Minor, B; Mitchell, J; Mogavero, E; Moiseenko, V A; Moltz, D M; Moore, C F; Morozov, V; Morse, R; De Moura, M M; Munhoz, M G; Mutchler, G S; Nelson, J M; Nevski, P; Ngo, T; Nguyen, M; Nguyen, T; Nikitin, V A; Nogach, L V; Noggle, T; Norman, B; Nurushev, S B; Nussbaum, T; Nystrand, J; Odyniec, Grazyna Janina; Ogawa, A; Ogilvie, C A; Olchanski, K; Oldenburg, M; Olson, D; Ososkov, G A; Ott, G; Padrazo, D; Paic, G; Pandey, S U; Panebratsev, Yu A; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Pentia, M; Perevozchikov, V; Peryt, W; Petrov, V; Pinganaud, W; Pirogov, S; Platner, E D; Pluta, J; Polk, I; Porile, N T; Porter, J; Poskanzer, A M; Potrebenikova, E V; Prindle, D J; Pruneau, C A; Puskar-Pasewicz, J; Rai, G; Rasson, J E; Ravel, O; Ray, R L; Razin, S V; Reichhold, D M; Reid, J; Renfordt, R E; Retière, F; Ridiger, A; Riso, J; Ritter, H G; Roberts, J B; Röhrich, D; Rogachevski, O V; Romero, J L; Roy, C; Russ, D; Rykov, V L; Sakrejda, I; Sánchez, R; Sandler, Z; Sandweiss, J; Sappenfield, P; Saulys, A C; Savin, I A; Schambach, J; Scharenberg, R P; Scheblien, J; Scheetz, R; Schlüter, R; Schmitz, N; Schröder, L S; Schulz, M; Schüttauf, A; Sedlmeir, J; Seger, J E; Seliverstov, D M; Seyboth, J; Seyboth, P; Seymour, R; Shakaliev, E I; Shestermanov, K E; Shi, Y; Shimansky, S S; Shuman, D B; Shvetcov, V S; Skoro, G P; Smirnov, N; Smykov, L P; Snellings, R; Solberg, K; Sowinski, J; Spinka, H M; Srivastava, B; Stephenson, E J; Stock, Reinhard; Stolpovsky, A; Stone, N; Stone, R; Strikhanov, M N; Stringfellow, B C; Ströbele, H; Struck, C; Suaide, A A P; Sugarbaker, E R; Suire, C; Symons, T J M; Takahashi, J; Tang, A H; Tarchini, A; Tarzian, J; Thomas, J H; Tikhomirov, V; Szanto de Toledo, A; Tonse, S R; Trainor, T; Trentalange, S; Tokarev, M; Tonjes, M B; Trofimov, V N; Tsai, O; Turner, K; Ullrich, T S; Underwood, D G; Vakula, I; Van Buren, G; Van der Molen, A; Vanyashin, A V; Vasilevskii, I M; Vasilev, A N; Vigdor, S E; Visser, G; Voloshin, S A; Vu, C; Wang, F; Ward, H; Weerasundara, D D; Weidenbach, R; Wells, R; Wenaus, T J; Westfall, G D; Whitfield, J P; Whitten, C; Wieman, H H; Willson, R; Wilson, K; Wirth, J; Wisdom, J; Wissink, S W; Witt, R; Wolf, J; Wood, L; Xu, N; Xu, Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yokosawa, A; Yurevich, V I; Zanevsky, Yu V; Zhang, J; Zhang, W M; Zhu, J; Zimmerman, D; Zoulkarneev, R; Zubarev, A N

    2001-01-01

    Elliptic flow from nuclear collisions is a hadronic observable sensitive to the early stages of system evolution. We report first results on elliptic flow of charged particles at midrapidity in Au+Au collisions at sqrt(s_NN)=130 GeV using the STAR TPC at RHIC. The elliptic flow signal, v_2, averaged over transverse momentum, reaches values of about 6% for relatively peripheral collisions and decreases for the more central collisions. This can be interpreted as the observation of a higher degree of thermalization than at lower collision energies. Pseudorapidity and transverse momentum dependence of elliptic flow are also presented.

  14. D and $^{3}He$ production in $\\sqrt{s}$ = 130 GeV Au + Au collisions

    CERN Document Server

    Adler, C; Allgower, C; Amonett, J; Anderson, B D; Anderson, M; Averichev, G S; Balewski, J T; Barannikova, O Yu; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellwied, R; Berger, J; Bichsel, H; Bland, L C; Blyth, C O; Bonner, B E; Boucham, A; Brandin, A B; Cadman, R V; Caines, H; Calderón de la Barca-Sanchez, M; Cardenas, A; Carroll, J; Castillo, J; Castro, M; Cebra, D; Chattopadhyay, S; Chen, M L; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Christie, W; Cormier, T M; Cramer, J G; Crawford, H J; De Mello, M; Deng, W S; Derevshchikov, A A; Didenko, L; Draper, J E; Dunin, V B; Dunlop, J C; Eckardt, V; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Fachini, P; Faine, V; Finch, E; Fisyak, Yu; Flierl, D; Foley, Kenneth J; Fu, J; Gagunashvili, N D; Gans, J; Gaudichet, L; Germain, M; Geurts, F J M; Ghazikhanian, V; Grabski, J; Grachov, O A; Greiner, D E; Grigoriev, V; Guedon, M; Guschin, E; Hallman, T J; Hardtke, D; Harris, J W; Heffner, M; Heppelmann, S; Herston, T; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Huang, H Z; Humanic, T J; Hümmler, H; Igo, G; Ishihara, A; Ivanshin, Yu I; Jacobs, P; Jacobs, W W; Janik, M; Johnson, I; Jones, P G; Judd, E; Kaneta, M; Kaplan, M; Keane, D; Kisiel, A; Klay, J L; Klein, S R; Klyachko, A A; Konstantinov, A S; Kotchenda, L; Kovalenko, A D; Krämer, M; Kravtsov, P; Krüger, K; Kuhn, C; Kulikov, A V; Kunde, G J; Kunz, C L; Kutuev, R K; Kuznetsov, A A; Lakehal-Ayat, L; Lamas-Valverde, J; Lamont, M A C; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lebedev, A; LeCompte, T J; Lednicky, R; Leontiev, V M; Le Vine, M J; Li, Q; Lindenbaum, S J; Lisa, M A; Ljubicic, T; Llope, W J; Lo Curto, G; Long, H; Longacre, R S; López-Noriega, M; Love, W A; Lynn, D; Majka, R; Margetis, S; Martin, L; Marx, J; Matis, H S; Matulenko, Yu A; McShane, T S; Meissner, F; Melnik, Yu M; Meshchanin, A P; Messer, M; Miller, M L; Milosevich, Z; Minaev, N G; Mitchell, J; Moiseenko, V A; Moltz, D; Moore, C F; Morozov, V; De Moura, M M; Munhoz, M G; Mutchler, G S; Nelson, J M; Nevski, P; Nikitin, V A; Nogach, L V; Norman, B; Nurushev, S B; Odyniec, Grazyna Janina; Ogawa, A; Okorokov, V; Oldenburg, M; Oson, D; Paic, G; Pandey, S U; Panebratsev, Yu A; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Perevozchikov, V; Peryt, W; Petrov, V A; Platner, E D; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potrebenikova, E V; Prindle, D J; Pruneau, C A; Radomski, S; Rai, G; Ravel, O; Ray, R L; Razin, S V; Reichhold, D M; Reid, J G; Retière, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Roy, C; Russ, D; Rykov, V L; Sakrejda, I; Sandweiss, J; Saulys, A C; Savin, I; Schambach, J; Scharenberg, R P; Schmitz, N; Schröder, L S; Schüttauf, A; Schweda, K; Seger, J E; Seliverstov, D M; Seyboth, P; Shahaliev, E; Shestermanov, K E; Shimansky, S S; Shvetcov, V S; Skoro, G P; Smirnov, N; Snellings, R; Sowinski, J; Spinka, H M; Srivastava, B; Stephenson, E J; Stock, Reinhard; Stolpovsky, A; Strikhanov, M N; Stringfellow, B C; Struck, C; Suaide, A A P; Sugarbaker, E R; Suire, C; Sumbera, M; Symons, T J M; Szanto de Toledo, A; Szarwas, P; Takahashi, J; Tang, A H; Thomas, J H; Tikhomirov, V; Trainor, T A; Trentalange, S; Tokarev, M; Tonjes, M B; Trofimov, V; Tsai, O; Turner, K; Ullrich, T S; Underwood, D G; Van Buren, G; Van der Molen, A; Vanyashin, A V; Vasilevski, I M; Vasilev, A N; Vigdor, S E; Voloshin, S A; Wang, F; Ward, H; Watson, J W; Wells, R; Wenaus, T J; Westfall, G D; Whitten, C; Wieman, H H; Willson, R; Wissink, S W; Witt, R; Xu, N; Xu, Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yokosawa, A; Yurevich, V I; Zanevsky, Yu V; Zborovský, I; Zhang, H; Zhang, W M; Zoulkarneev, R; Zubarev, A N; 10.1103/PhysRevLett.87.262301

    2001-01-01

    The first measurements of light antinucleus production in Au + Au collisions at the Relativistic Heavy-Ion Collider are reported. The observed production rates for d and /sup 3/He are much larger than in lower energy nucleus-nucleus collisions. A coalescence model analysis of the yields indicates that there is little or no increase in the antinucleon freeze-out volume compared to collisions at CERN SPS energy. These analyses also indicate that the 3He freeze-out volume is smaller than the d freeze-out volume. (22 refs).

  15. Nuclear Stopping in Central Au+Au Collisions at RHIC Energies

    Directory of Open Access Journals (Sweden)

    Ying Yuan

    2014-01-01

    Full Text Available Nuclear stopping in central Au+Au collisions at relativistic heavy-ion collider (RHIC energies is studied in the framework of a cascade mode and the modified ultrarelativistic quantum molecular dynamics (UrQMD transport model. In the modified mode, the mean field potentials of both formed and “preformed” hadrons (from string fragmentation are considered. It is found that the nuclear stopping is increasingly influenced by the mean-field potentials in the projectile and target regions with the increase of the reaction energy. In the central region, the calculations of the cascade model considering the modifying factor can describe the experimental data of the PHOBOS collaboration.

  16. Coût des soins de santé attribuables au tabagisme au Cambodge ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Cambodge, l'incidence de la tuberculose et du tabagisme est élevée de sorte que le coût du tabagisme comprendra aussi le coût des décès " supplémentaires " occasionnés par la tuberculose liée au tabagisme. Dans ce pays, les systèmes d'information sur la santé ne sont ni rigoureux, ni fiables. Par conséquent, on ne ...

  17. Relativistic multireference many-body perturbation theory calculations on Au64+ - Au69+ ions

    Energy Technology Data Exchange (ETDEWEB)

    Vilkas, M J; Ishikawa, Y; Trabert, E

    2006-03-31

    Many-body perturbation theory (MBPT) calculations are an adequate tool for the description of the structure of highly charged multi-electron ions and for the analysis of their spectra. They demonstrate this by way of a re-investigation of n=3, {Delta}n=0 transitions in the EUV spectra of Na-, Mg-, Al-like, and Si-like ions of Au that have been obtained previously by heavy-ion accelerator based beam-foil spectroscopy. They discuss the evidence and propose several revisions on the basis of the multi-reference many-body perturbation theory calculations of Ne- through P-like ions of Au.

  18. Measurements of direct photons in Au+Au collisions with PHENIX

    CERN Document Server

    Bannier, Benjamin

    2014-01-01

    The PHENIX experiment has published direct photon yields and elliptic flow coefficients $v_2$ from Au+Au collisions at RHIC energies. These results have sparked much theoretical discussion. The measured yields and flow parameters are difficult to reconcile in current model calculations of thermal radiation based on hydrodynamic time evolution of the collision volume. Our latest analyses which use high statistics data from the 2007 and 2010 runs allow the determination of direct photon yields with finer granularity in centrality and photon momentum and down to $p_T$ as low as 0.4 GeV/$c$. We will summarize the current status and present new results from PHENIX.

  19. Au/Pd core-shell nanoparticles with varied hollow Au cores for enhanced formic acid oxidation

    Science.gov (United States)

    Hsu, Chiajen; Huang, Chienwen; Hao, Yaowu; Liu, Fuqiang

    2013-03-01

    A facile method has been developed to synthesize Au/Pd core-shell nanoparticles via galvanic replacement of Cu by Pd on hollow Au nanospheres. The unique nanoparticles were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, ultraviolet-visible spectroscopy, and electrochemical measurements. When the concentration of the Au solution was decreased, grain size of the polycrystalline hollow Au nanospheres was reduced, and the structures became highly porous. After the Pd shell formed on these Au nanospheres, the morphology and structure of the Au/Pd nanoparticles varied and hence significantly affected the catalytic properties. The Au/Pd nanoparticles synthesized with reduced Au concentrations showed higher formic acid oxidation activity (0.93 mA cm-2 at 0.3 V) than the commercial Pd black (0.85 mA cm-2 at 0.3 V), suggesting a promising candidate as fuel cell catalysts. In addition, the Au/Pd nanoparticles displayed lower CO-stripping potential, improved stability, and higher durability compared to the Pd black due to their unique core-shell structures tuned by Au core morphologies.

  20. Conductive Au nanowires regulated by silk fibroin nanofibers

    Science.gov (United States)

    Dong, Bo-Ju; Lu, Qiang

    2014-03-01

    Conductive Au-biopolymer composites have promising applications in tissue engineering such as nerve tissue regeneration. In this study, silk fibroin nanofibers were formed in aqueous solution by regulating silk self-assembly process and then used as template for Au nanowire fabrication. We performed the synthesis of Au seeds by repeating the seeding cycles for several times in order to increase the density of Au seeds on the nanofibers. After electroless plating, densely decorated Au seeds grew into irregularly shaped particles following silk nanofiber to fill the gaps between particles and finally form uniform continuous nanowires. The conductive property of the Au-silk fibroin nanowires was studied with current-voltage ( I-V) measurement. A typical ohmic behavior was observed, which highlighted their potential applications in nerve tissue regeneration.