WorldWideScience

Sample records for related topics 19-21

  1. Discriminative Relational Topic Models.

    Science.gov (United States)

    Chen, Ning; Zhu, Jun; Xia, Fei; Zhang, Bo

    2015-05-01

    Relational topic models (RTMs) provide a probabilistic generative process to describe both the link structure and document contents for document networks, and they have shown promise on predicting network structures and discovering latent topic representations. However, existing RTMs have limitations in both the restricted model expressiveness and incapability of dealing with imbalanced network data. To expand the scope and improve the inference accuracy of RTMs, this paper presents three extensions: 1) unlike the common link likelihood with a diagonal weight matrix that allows the-same-topic interactions only, we generalize it to use a full weight matrix that captures all pairwise topic interactions and is applicable to asymmetric networks; 2) instead of doing standard Bayesian inference, we perform regularized Bayesian inference (RegBayes) with a regularization parameter to deal with the imbalanced link structure issue in real networks and improve the discriminative ability of learned latent representations; and 3) instead of doing variational approximation with strict mean-field assumptions, we present collapsed Gibbs sampling algorithms for the generalized relational topic models by exploring data augmentation without making restricting assumptions. Under the generic RegBayes framework, we carefully investigate two popular discriminative loss functions, namely, the logistic log-loss and the max-margin hinge loss. Experimental results on several real network datasets demonstrate the significance of these extensions on improving prediction performance.

  2. Relativity theory - topical

    International Nuclear Information System (INIS)

    Schmutzer, E.

    1979-01-01

    Issued on the occasion of Albert Einstein's 100th birthday the book deals topically with the special and general relativity theory. The latest experiments to confirm the relativity theory are described and the historical development of the theory is presented in detail. Emphasis is given to the disclosure of deep insights into the nature of matter. Of interest to experts in physical and natural sciences and to mathematicians

  3. Superconcentration and related topics

    CERN Document Server

    Chatterjee, Sourav

    2014-01-01

    A certain curious feature of random objects, introduced by the author as “super concentration,” and two related topics, “chaos” and “multiple valleys,” are highlighted in this book. Although super concentration has established itself as a recognized feature in a number of areas of probability theory in the last twenty years (under a variety of names), the author was the first to discover and explore its connections with chaos and multiple valleys. He achieves a substantial degree of simplification and clarity in the presentation of these findings by using the spectral approach. Understanding the fluctuations of random objects is one of the major goals of probability theory and a whole subfield of probability and analysis, called concentration of measure, is devoted to understanding these fluctuations. This subfield offers a range of tools for computing upper bounds on the orders of fluctuations of very complicated random variables. Usually, concentration of measure is useful when more direct prob...

  4. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1983-01-01

    Probabilistic Analysis and Related Topics, Volume 3 focuses on the continuity, integrability, and differentiability of random functions, including operator theory, measure theory, and functional and numerical analysis. The selection first offers information on the qualitative theory of stochastic systems and Langevin equations with multiplicative noise. Discussions focus on phase-space evolution via direct integration, phase-space evolution, linear and nonlinear systems, linearization, and generalizations. The text then ponders on the stability theory of stochastic difference systems and Marko

  5. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1979-01-01

    Probabilistic Analysis and Related Topics, Volume 2 focuses on the integrability, continuity, and differentiability of random functions, as well as functional analysis, measure theory, operator theory, and numerical analysis.The selection first offers information on the optimal control of stochastic systems and Gleason measures. Discussions focus on convergence of Gleason measures, random Gleason measures, orthogonally scattered Gleason measures, existence of optimal controls without feedback, random necessary conditions, and Gleason measures in tensor products. The text then elaborates on an

  6. Stochastic Analysis and Related Topics

    CERN Document Server

    Ustunel, Ali

    1988-01-01

    The Silvri Workshop was divided into a short summer school and a working conference, producing lectures and research papers on recent developments in stochastic analysis on Wiener space. The topics treated in the lectures relate to the Malliavin calculus, the Skorohod integral and nonlinear functionals of white noise. Most of the research papers are applications of these subjects. This volume addresses researchers and graduate students in stochastic processes and theoretical physics.

  7. 27 CFR 19.21 - Tax.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Tax. 19.21 Section 19.21 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Taxes Gallonage Taxes § 19.21 Tax. (a) A tax is imposed by 26 U.S...

  8. Hugging fusion and related topics

    Energy Technology Data Exchange (ETDEWEB)

    Iwamoto, Akira [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-07-01

    An important problem related to the synthesis of very heavy nuclides by fusion of two heavy-ions is the extra push effect. To avoid it, we propose a hugging fusion, which is the fusion of two well-deformed heavy-ions. (author)

  9. Neutron spectroscopy, nuclear structure, related topics. Abstracts

    International Nuclear Information System (INIS)

    Sukhovoj, A.M.

    1996-01-01

    Neutron spectroscopy, nuclear structure and related topics are considered. P, T-breaking, neutron beta decay, neutron radiative capture and neutron polarizability are discussed. Reaction with fast neutrons, methodical aspect low-energy fission are considered too

  10. Conference on Stochastic Analysis and Related Topics

    CERN Document Server

    Peterson, Jonathon

    2017-01-01

    The articles in this collection are a sampling of some of the research presented during the conference “Stochastic Analysis and Related Topics”, held in May of 2015 at Purdue University in honor of the 60th birthday of Rodrigo Bañuelos. A wide variety of topics in probability theory is covered in these proceedings, including heat kernel estimates, Malliavin calculus, rough paths differential equations, Lévy processes, Brownian motion on manifolds, and spin glasses, among other topics.

  11. Workshop on beam cooling and related topics

    International Nuclear Information System (INIS)

    Bosser, J.

    1994-01-01

    The sessions of the Workshop on Beam Cooling and Related Topics, held in Montreux from 4-8 October 1993, are reported in these Proceedings. This meeting brought together international experts in the field of accelerator beam cooling. Its purpose was to discuss the status of the different cooling techniques currently in use (stochastic, electron, ionization, heavy-ion, and laser) and their actual performances, technological implications, and future prospects. Certain theoretical principles (muon cooling, cyclotron maser cooling) were discussed and are reported on in these Proceedings. Also of interest in this Workshop was the possibility of beam crystallization in accelerators using ultimate cooling. In the first part of these Proceedings, overview talks on the various cooling techniques, their implications, present performance, and future prospects are presented. More detailed reports on all the topics are then given in the form of oral presentations or poster sessions. Finally, the chairmen and/or convenors then present summary talks. (orig.)

  12. Ego Involvement and Topic Controversiality as Related to Attitude Change.

    Science.gov (United States)

    Sledden, Elizabeth A.; Fernandez, Katherine A.

    Attitude change was measured on four different topics before and immediately after a persuasion was presented in order to compare the degree of change with the level of ego involvement as it relates to topic controversiality. Ego involvement was based on self-ratings of concern for each topic. Objective topic controversiality was based on the…

  13. Topical thrombin-related corneal calcification.

    Science.gov (United States)

    Kiratli, Hayyam; Irkeç, Murat; Alaçal, Sibel; Söylemezoğlu, Figen

    2006-09-01

    To report a highly unusual case of corneal calcification after brief intraoperative use of topical thrombin. A 44-year-old man underwent sclerouvectomy for ciliochoroidal leiomyoma, during which 35 UNIH/mL lyophilized bovine thrombin mixed with 9 mL of diluent containing 1500 mmol/mL calcium chloride was used. From the first postoperative day, corneal and anterior lenticular capsule calcifications developed, and corneal involvement slightly enlarged thereafter. A year later, 2 corneal punch biopsies confirmed calcification mainly in the Bowman layer. Topical treatment with 1.5% ethylenediaminetetraacetic acid significantly restored corneal clarity. Six months later, a standard extracapsular cataract extraction with intraocular lens placement improved visual acuity to 20/60. This case suggests that topical thrombin drops with elevated calcium concentrations may cause acute corneal calcification in Bowman layer and on the anterior lens capsule.

  14. 49 CFR 19.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Standards for financial management systems. 19.21... ORGANIZATIONS Post-Award Requirements § 19.21 Standards for financial management systems. (a) Federal awarding... information whenever practical. (b) Recipients' financial management systems shall provide for the following...

  15. Shock wave dynamics derivatives and related topics

    CERN Document Server

    Emanuel, George

    2012-01-01

    "...this monograph develops an esoteric niche within shock wave theory. …treats shock waves from an analytical approach assuming perfect gas. Emanuel has made significant contributions to the theory of shock waves and has selected a number of topics that reflect those contributions."-Shock Waves, 2013.

  16. Selected papers on analysis and related topics

    CERN Document Server

    2008-01-01

    This volume contains translations of papers that originally appeared in the Japanese journal Sūgaku. The papers range over a variety of topics, including operator algebras, analysis, and statistics. This volume is suitable for graduate students and research mathematicians interested in analysis and its applications.

  17. Developments in functional equations and related topics

    CERN Document Server

    Ciepliński, Krzysztof; Rassias, Themistocles

    2017-01-01

    This book presents current research on Ulam stability for functional equations and inequalities. Contributions from renowned scientists emphasize fundamental and new results, methods and techniques. Detailed examples are given to theories to further understanding at the graduate level for students in mathematics, physics, and engineering. Key topics covered in this book include: Quasi means Approximate isometries Functional equations in hypergroups Stability of functional equations Fischer-Muszély equation Haar meager sets and Haar null sets Dynamical systems Functional equations in probability theory Stochastic convex ordering Dhombres functional equation Nonstandard analysis and Ulam stability This book is dedicated in memory of Staniłsaw Marcin Ulam, who posed the fundamental problem concerning approximate homomorphisms of groups in 1940; which has provided the stimulus for studies in the stability of functional equations and inequalities.

  18. Inertial confinement fusion and related topics

    International Nuclear Information System (INIS)

    Starodub, A. N.

    2007-01-01

    The current state of different approaches (laser fusion, light and heavy ions, electron beam) to the realization of inertial confinement fusion is considered. From comparative analysis a conclusion is made that from the viewpoint of physics, technology, safety, and economics the most realistic way to future energetics is an electric power plant based on a hybrid fission-fusion reactor which consists of an external source of neutrons (based on laser fusion) and a subcritical two-cascade nuclear blanket, which yields the energy under the action of 14 MeV neutrons. The main topics on inertial confinement fusion such as the energy driver, the interaction between plasmas and driver beam, the target design are discussed. New concept of creation of a laser driver for IFE based on generation and amplification of radiation with controllable coherence is reported. The performed studies demonstrate that the laser based on generation and amplification of radiation with controllable coherence (CCR laser) has a number of advantages as compared to conventional schemes of lasers. The carried out experiments have shown a possibility of suppression of small-scale self-focusing, formation of laser radiation pulses with required characteristics, simplification of an optical scheme of the laser, good matching of laser-target system and achievement of homogeneous irradiation and high output laser energy density without using traditional correcting systems (phase plates, adaptive optics, space filters etc.). The results of the latest experiments to reach ultimate energy characteristics of the developed laser system are also reported. Recent results from the experiments aimed at studying of the physical processes in targets under illumination by the laser with controllable coherence of radiation are presented and discussed, especially such important laser-matter interaction phenomena as absorption and scattering of the laser radiation, the laser radiation harmonic generation, X

  19. Diffusion processes and related topics in biology

    CERN Document Server

    Ricciardi, Luigi M

    1977-01-01

    These notes are based on a one-quarter course given at the Department of Biophysics and Theoretical Biology of the University of Chicago in 1916. The course was directed to graduate students in the Division of Biological Sciences with interests in population biology and neurobiology. Only a slight acquaintance with probability and differential equations is required of the reader. Exercises are interwoven with the text to encourage the reader to play a more active role and thus facilitate his digestion of the material. One aim of these notes is to provide a heuristic approach, using as little mathematics as possible, to certain aspects of the theory of stochastic processes that are being increasingly employed in some of the population biol­ ogy and neurobiology literature. While the subject may be classical, the nov­ elty here lies in the approach and point of view, particularly in the applica­ tions such as the approach to the neuronal firing problem and its related dif­ fusion approximations. It is a ple...

  20. The Burnside problem and related topics

    International Nuclear Information System (INIS)

    Adian, Sergei I

    2011-01-01

    This paper gives a survey of results related to the famous Burnside problem on periodic groups. A negative solution of this problem was first published in joint papers of P.S. Novikov and the author in 1968. The theory of transformations of words in free periodic groups that was created in these papers and its various modifications give a very productive approach to the investigation of hard problems in group theory. In 1950 the Burnside problem gave rise to another problem on finite periodic groups, formulated by Magnus and called by him the restricted Burnside problem. Here it is called the Burnside-Magnus problem. In the Burnside problem the question of local finiteness of periodic groups of a given exponent was posed, but the Burnside-Magnus problem is the question of the existence of a maximal finite periodic group R(m,n) of a fixed period n with a given number m of generators. These problems complement each other. The publication in a joint paper by the author and Razborov in 1987 of the first effective proof of the well-known result of Kostrikin on the existence of a maximal group R(m,n) for any prime n, together with an indication of primitive recursive upper bounds for the orders of these groups, stimulated investigations of the Burnside-Magnus problem as well. Very soon other effective proofs appeared, and then Zel'manov extended Kostrikin's result to the case when n is any power of a prime number. These results are discussed in the last section of this paper. Bibliography: 105 titles.

  1. International Conference on Advances of Fractals and Related Topics

    CERN Document Server

    Lau, Ka-Sing

    2014-01-01

    This volume collects thirteen expository or survey articles on topics including Fractal Geometry, Analysis of Fractals, Multifractal Analysis, Ergodic Theory and Dynamical Systems, Probability and Stochastic Analysis, written by the leading experts in their respective fields. The articles are based on papers presented at the International Conference on Advances on Fractals and Related Topics, held on December 10-14, 2012 at the Chinese University of Hong Kong. The volume offers insights into a number of exciting, cutting-edge developments in the area of fractals, which has close ties to and applications in other areas such as analysis, geometry, number theory, probability and mathematical physics.   

  2. Spring School on Superstring Theory and Related Topics

    CERN Document Server

    2017-01-01

    ICTP's annual Spring School on Superstring Theory and Related Topics provides pedagogical treatment of these subjects through lectures by some of the world's top string theorists. The activity is intended for theoretical physicists or mathematicians with knowledge of quantum field theory, general relativity and string theory. It is organized in collaboration with the Asia Pacific Center for Theoretical Physics (APCTP) and the Italian Institute for Nuclear Physics (INFN).

  3. Proceedings of a meeting on radiation shielding and related topics

    International Nuclear Information System (INIS)

    1978-01-01

    This is a proceedings of a meeting on radiation shielding and related topics held on Feb. 22 and 23 in 1978 at Nuclear Engineering Research Laboratory of University of Tokyo. The reports includes the following items (1) studies on neutronics with accelerators (2) radiation damage (3) shielding design (4) radiation streaming (5) shielding experiments from a point of view of radiation measurements (6) shielding benchmark experiments (7) prospects on the study of neutronics. All items are written in Japanese. (auth.)

  4. Partially annotated bibliography for computer protection and related topics

    Energy Technology Data Exchange (ETDEWEB)

    Huskamp, J.C.

    1976-07-20

    References for the commonly cited technical papers in the area of computer protection are given. Great care is taken to exclude papers with no technical content or merit. For the purposes of this bibliography, computer protection is broadly defined to encompass all facets of the protection problem. The papers cover, but are not limited to, the topics of protection features in operating systems (e.g., MULTICS and HYDRA), hardware implementations of protection facilities (e.g., Honeywell 6180, System 250, BCC 5000, B6500), data base protection controls, confinement and protection models. Since computer protection is related to many other areas in computer science and electrical engineering, a bibliography of related areas is included after the protection bibliography. These sections also include articles of general interest in the named areas which are not necessarily related to protection.

  5. The Coulomb potential in quantum mechanics and related topics

    International Nuclear Information System (INIS)

    Haeringen, H. van.

    1978-01-01

    This dissertation consists of an analytic study of the Coulomb interaction in nonrelativistic quantum mechanics and some related topics. The author investigates in a number of self-contained articles various interesting and important properties of the Coulomb potential. Some of these properties are shared by other potentials which also play a role in quantum mechanics. For such related interactions a comparative study is made. The principal difficulties in the description of proton-deuteron scattering and break-up reactions, due to the Coulomb interaction, are studied by working out a simple model. The bound states are studied for the Coulomb plus Yamaguchi potential, for the symmetric shifted Coulomb potential, and for local potentials with an inverse-distance-squared asymptotic behaviour. (Auth.)

  6. ISINN-3. Neutron spectroscopy, nuclear structure, related topics

    International Nuclear Information System (INIS)

    1995-01-01

    The proceedings contain the materials presented at the Third International Seminar on Neutron-Nucleus Interactions (ISINN-3) dealing with the problems of neutron spectroscopy, nuclear structure and related topics. The Seminar took place in Dubna on April 26-28, 1995. Over 100 scientists from Belgium, Bulgaria, Czech Republic, Germany, Japan, Latvia, Mexico, Poland, Slovakia, Ukraine, USA and from more than 10 Russian research institutes took part in the Seminar. The Seminar is dedicated to the memory of the founder of the Neutron Physics Laboratory of JINR, the famous soviet scientist Professor Fedor L. Shapiro, whose 80th anniversary is being observed. The main problems discussed are the following: fundamental interactions and symmetries in neutron-induced reactions, fundamental properties of the neutron, properties of excited nuclei after neutron capture and some other ones. Special emphasis is laid upon γ decay and neutron induced nuclear fission as well as upon the methodical aspects of new experiments

  7. ISINN-2. Neutron spectroscopy, nuclear structure and related topics

    International Nuclear Information System (INIS)

    1994-01-01

    The proceedings contain the materials presented at the Second International Seminar on Neutron-Nucleus Interactions (ISINN-2) dealing with the problems of neutron spectroscopy, nuclear structure and related topics. The Seminar took place in Dubna on April 26-28, 1994. Over 120 scientists from Belgium, Bulgaria, Czech Republic, Germany, Holland, Italy, Japan, Latvia, Mexico, Poland, Slovakia, Slovenia, Ukraine, US and about 10 Russian research institutes took part in the Seminar. The main problems discussed are the following: P-odd and P-even angular correlation and T-reversal invariance in neutron reactions, nuclear structure investigations by neutron capture, the mechanism of neutron reactions, nuclear fission processes, as well as neutron data for nuclear astrophysics

  8. Conformal Field Theory, Automorphic Forms and Related Topics

    CERN Document Server

    Weissauer, Rainer; CFT 2011

    2014-01-01

    This book, part of the series Contributions in Mathematical and Computational Sciences, reviews recent developments in the theory of vertex operator algebras (VOAs) and their applications to mathematics and physics.   The mathematical theory of VOAs originated from the famous monstrous moonshine conjectures of J.H. Conway and S.P. Norton, which predicted a deep relationship between the characters of the largest simple finite sporadic group, the Monster, and the theory of modular forms inspired by the observations of J. MacKay and J. Thompson.   The contributions are based on lectures delivered at the 2011 conference on Conformal Field Theory, Automorphic Forms and Related Topics, organized by the editors as part of a special program offered at Heidelberg University that summer under the sponsorship of the MAThematics Center Heidelberg (MATCH).

  9. Thoracostomy tubes: A comprehensive review of complications and related topics

    Science.gov (United States)

    Kwiatt, Michael; Tarbox, Abigail; Seamon, Mark J.; Swaroop, Mamta; Cipolla, James; Allen, Charles; Hallenbeck, Stacinoel; Davido, H. Tracy; Lindsey, David E.; Doraiswamy, Vijay A.; Galwankar, Sagar; Tulman, David; Latchana, Nicholas; Papadimos, Thomas J.; Cook, Charles H.; Stawicki, Stanislaw P.

    2014-01-01

    Tube thoracostomy (TT) placement belongs among the most commonly performed procedures. Despite many benefits of TT drainage, potential for significant morbidity and mortality exists. Abdominal or thoracic injury, fistula formation and vascular trauma are among the most serious, but more common complications such as recurrent pneumothorax, insertion site infection and nonfunctioning or malpositioned TT also represent a significant source of morbidity and treatment cost. Awareness of potential complications and familiarity with associated preventive, diagnostic and treatment strategies are fundamental to satisfactory patient outcomes. This review focuses on chest tube complications and related topics, with emphasis on prevention and problem-oriented approaches to diagnosis and treatment. The authors hope that this manuscript will serve as a valuable foundation for those who wish to become adept at the management of chest tubes. PMID:25024942

  10. Stability of nonlinear waves and patterns and related topics

    Science.gov (United States)

    Ghazaryan, Anna; Lafortune, Stephane; Manukian, Vahagn

    2018-04-01

    Periodic and localized travelling waves such as wave trains, pulses, fronts and patterns of more complex structure often occur in natural and experimentally built systems. In mathematics, these objects are realized as solutions of nonlinear partial differential equations. The existence, dynamic properties and bifurcations of those solutions are of interest. In particular, their stability is important for applications, as the waves that are observable are usually stable. When the waves are unstable, further investigation is warranted of the way the instability is exhibited, i.e. the nature of the instability, and also coherent structures that appear as a result of an instability of travelling waves. A variety of analytical, numerical and hybrid techniques are used to study travelling waves and their properties. This article is part of the theme issue `Stability of nonlinear waves and patterns and related topics'.

  11. FCC-ee Physics workshop | 19-21 June 2014

    CERN Multimedia

    2014-01-01

    The 7th FCC-ee/TLEP workshop, the first after the FCC kick-off in February 2014, will be focused on physics and experiments.     It will take place on 19-21 June at CERN in the TH auditorium. The registration is open and the agenda is available on the indico web page: http://indico.cern.ch/event/313708/. You are all cordially invited to attend! This will be the first in a series of workshops that will lead us to the first FCC-ee physics milestone, a document defining the physics landscape and study plans, required for March 2015. More information can be found here. FCC-ee is a high-luminosity Z, W, Higgs and top factory, to be hosted in a 100km tunnel, possibly as the first step towards a 100 TeV pp collider FCC-hh. These two machines are being studied within the FCC design study. High precision, high statistics and a clean environment are the tools available in FCC-ee to shed light on the unknown physics that underlies present mysteries: dark matter, the baryon asymmetry of th...

  12. Group and Topic Discovery from Relations and Their Attributes

    National Research Council Canada - National Science Library

    Wang, Xuerui; Mohanty, Natasha; McCallum, Andrew

    2006-01-01

    The authors present a probabilistic generative model of entity relationships and their attributes that simultaneously discovers groups among the entities and topics among the corresponding textual attributes...

  13. Database of Literature on Guided Imagery and Music and Related Topics

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2015-01-01

    A March 2015 update of the largest international database on literature on Guided Imagery and Music and related topics.......A March 2015 update of the largest international database on literature on Guided Imagery and Music and related topics....

  14. 49 CFR 1242.19 - Electric power systems (account XX-19-21).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Electric power systems (account XX-19-21). 1242.19... Structures § 1242.19 Electric power systems (account XX-19-21). Separate common expenses on basis of common expenses of electric power purchased or produced for motive power (accounts XX-51-68 and XX-52-68). ...

  15. Topology of real algebraic varieties and related topics

    CERN Document Server

    Kharlamov, V M; Polotovskiĭ, G M; Viro, Oleg Ya

    1996-01-01

    This volume is dedicated to the memory of the Russian mathematician D. A. Gudkov. It contains papers written by his friends, students, and collaborators and is devoted mainly to the areas where D. A. Gudkov made important contributions. The main topic is the topology of real algebraic varieties. Several papers include new results on the topology of real plane algebraic curves (the Hilbert 16th problem).

  16. International Conference on Ergodic Theory and Related Topics

    CERN Document Server

    Richter, Karin; Warstat, Volker

    1992-01-01

    The purpose of the conference was to represent recent developments in measure theoretic, differentiable and topological dynamical systems as well as connections to probability theory, stochastic processes, operator theory and statistical physics. Only original research papers that do not appear elsewhere are included in the proceedings. Their topics include: C(2)-diffeomorphisms of compact Riemann manifolds, geodesic flows, chaotic behaviour in billards, nonlinear ergodic theory, central limit theorems for subadditive processes, Hausdorff measures for parabolic rational maps, Markov operators, periods of cycles, Julia sets, ergodic theorems. From the Contents: L.A. Bunimovich: On absolutely focusing mirrors.- M. Denker, M. Urbanski: The dichotomy of Hausdorff measures and equilibrium states for parabolic rational maps.- F. Ledrappier: Ergodic properties of the stable foliations.- U. Wacker: Invariance principles and central limit theorems for nonadditive stationary processes.- J. Schmeling, R. Siegmund-Schult...

  17. Topic shift impairs pronoun resolution during sentence comprehension: Evidence from event-related potentials.

    Science.gov (United States)

    Xu, Xiaodong; Zhou, Xiaolin

    2016-02-01

    This study investigated how topic shift and topic continuation influence pronoun interpretation in Chinese. ERPs recorded on pronouns in topic structure showed stronger and earlier late positive responses (P600) for the topic-shift than for the topic-continuation conditions. However, in nontopic structure where the subject (denoting only subjecthood), rather than the topic (denoting both topichood and subjecthood), acted as the antecedent of the pronoun, almost indistinguishable P600 responses were obtained on the pronoun regardless of whether it was referring to the subject (i.e., subject continuation) or the object (i.e., subject shift). Moreover, stronger and earlier P600 responses were elicited by pronouns in the topic-shift than in the subject-shift conditions, although there was no difference between the topic-continuation and the subject-continuation conditions. These findings suggest that topic shift results in greater difficulty in the resolution stage of referential processing, although the bonding process is not sensitive to the manipulation of topic status, and that topic has a privileged cognitive status relative to other nontopic entities (e.g., subject) in real-time language processing. © 2015 Society for Psychophysiological Research.

  18. Topics in the Foundations of General Relativity and Newtonian Gravitation Theory

    CERN Document Server

    Malament, David B

    2012-01-01

    In Topics in the Foundations of General Relativity and Newtonian Gravitation Theory, David B. Malament presents the basic logical-mathematical structure of general relativity and considers a number of special topics concerning the foundations of general relativity and its relation to Newtonian gravitation theory. These special topics include the geometrized formulation of Newtonian theory (also known as Newton-Cartan theory), the concept of rotation in general relativity, and Gödel spacetime. One of the highlights of the book is a no-go theorem that can be understood to show that there is

  19. Hot Topics in Pharmacogenetics of Age-Related Macular Degeneration.

    Science.gov (United States)

    Schwartz, Stephen G; Brantley, Milam A; Kovach, Jaclyn L; Grzybowski, Andrzej

    2017-01-01

    Age-related macular degeneration (AMD) is a leading cause of irreversible visual loss and is primarily treated with nutritional supplementation as well as with anti-vascular endothelial growth factor (VEGF) agents for certain patients with neovascular disease. AMD is a complex disease with both genetic and environmental risk factors. In addition, treatment outcomes from nutritional supplementation and anti-VEGF agents vary considerably. Therefore, it is reasonable to suspect that there may be pharmacogenetic influences on these treatments. Many series have reported individual associations with variants in complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), and other loci. However, at this time there are no validated associations. With respect to AMD, pharmacogenetics remains an intriguing area of research but is not helpful for routine clinical management. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  20. Automatic topic identification of health-related messages in online health community using text classification.

    Science.gov (United States)

    Lu, Yingjie

    2013-01-01

    To facilitate patient involvement in online health community and obtain informative support and emotional support they need, a topic identification approach was proposed in this paper for identifying automatically topics of the health-related messages in online health community, thus assisting patients in reaching the most relevant messages for their queries efficiently. Feature-based classification framework was presented for automatic topic identification in our study. We first collected the messages related to some predefined topics in a online health community. Then we combined three different types of features, n-gram-based features, domain-specific features and sentiment features to build four feature sets for health-related text representation. Finally, three different text classification techniques, C4.5, Naïve Bayes and SVM were adopted to evaluate our topic classification model. By comparing different feature sets and different classification techniques, we found that n-gram-based features, domain-specific features and sentiment features were all considered to be effective in distinguishing different types of health-related topics. In addition, feature reduction technique based on information gain was also effective to improve the topic classification performance. In terms of classification techniques, SVM outperformed C4.5 and Naïve Bayes significantly. The experimental results demonstrated that the proposed approach could identify the topics of online health-related messages efficiently.

  1. Discussion series on PURPA related topics: information to customers

    Energy Technology Data Exchange (ETDEWEB)

    Sturgeon, J I

    1980-08-01

    This volume relates primarily to Time-of-Day rates standard, PURPA IB(d)3, and deals with the content and methods of providing rate and conservation information to customers when Time-of-Day rates are used. Information to customers in the Demonstration and Pilot Projects fell mainly into four categories: administrative communications; explanations of new rate structures; information and advice on load management; and facts, recommendations and encouragements about energy conservation and end-use improvement. Administrative communications were about such matters as the existence of Projects, their funding, their periods of performance, the selection of their test customers, conditions of participation, procedural changes during the tests, and the time and conditions of ending the tests. These communications were important to good customer cooperation. All Demonstration Projects devoted considerable effort to the crucial task of clearly explaining the rationale of Time-of-Use (TOU) pricing and the test rate structures. The Projects then presented the concept of TOU pricing as a means of (a) fairly charging customers the true cost of their electricity and (b) rewarding them for shifting consumption to times when costs are less. For the most part, Demonstration Projects gave specific information on the individual customer's own rate structure and none on any others that were under test. The information was presented in face-to-face interviews, group presentations, television, radio, and print media, and traveling exhibits. The results are evaluated. (LCL)

  2. Capture gamma-ray spectroscopy and related topics, 1984. AIP conference proceedings No. 125

    International Nuclear Information System (INIS)

    Raman, S.

    1985-01-01

    The main topics discussed at the symposium were nuclear models and theory, photon-induced reactions, neutron-induced reactions, charged-particle-induced reactions, applications, including nucleosynthesis, and related topics. Separate entries were prepared for the data base for the papers presented

  3. Expression and Organization of Geographic Spatial Relations Based on Topic Maps

    Science.gov (United States)

    Liang, H. J.; Wang, H.; Cui, T. J.; Guo, J. F.

    2017-09-01

    Spatial Relation is one of the important components of Geographical Information Science and Spatial Database. There have been lots of researches on Spatial Relation and many different spatial relations have been proposed. The relationships among these spatial relations such as hierarchy and so on are complex and this brings some difficulties to the applications and teaching of these spatial relations. This paper summaries some common spatial relations, extracts the topic types, association types, resource types of these spatial relations using the technology of Topic Maps, and builds many different relationships among these spatial relations. Finally, this paper utilizes Java and Ontopia to build a topic map among these common spatial relations, forms a complex knowledge network of spatial relations, and realizes the effective management and retrieval of spatial relations.

  4. Topic structure affects semantic integration: evidence from event-related potentials.

    Science.gov (United States)

    Yang, Xiaohong; Chen, Xuhai; Chen, Shuang; Xu, Xiaoying; Yang, Yufang

    2013-01-01

    This study investigated whether semantic integration in discourse context could be influenced by topic structure using event-related brain potentials. Participants read discourses in which the last sentence contained a critical word that was either congruent or incongruent with the topic established in the first sentence. The intervening sentences between the first and the last sentence of the discourse either maintained or shifted the original topic. Results showed that incongruent words in topic-maintained discourses elicited an N400 effect that was broadly distributed over the scalp while those in topic-shifted discourses elicited an N400 effect that was lateralized to the right hemisphere and localized over central and posterior areas. Moreover, a late positivity effect was only elicited by incongruent words in topic-shifted discourses, but not in topic-maintained discourses. This suggests an important role for discourse structure in semantic integration, such that compared with topic-maintained discourses, the complexity of discourse structure in topic-shifted condition reduces the initial stage of semantic integration and enhances the later stage in which a mental representation is updated.

  5. Health-related hot topic detection in online communities using text clustering.

    Directory of Open Access Journals (Sweden)

    Yingjie Lu

    Full Text Available Recently, health-related social media services, especially online health communities, have rapidly emerged. Patients with various health conditions participate in online health communities to share their experiences and exchange healthcare knowledge. Exploring hot topics in online health communities helps us better understand patients' needs and interest in health-related knowledge. However, the statistical topic analysis employed in previous studies is becoming impractical for processing the rapidly increasing amount of online data. Automatic topic detection based on document clustering is an alternative approach for extracting health-related hot topics in online communities. In addition to the keyword-based features used in traditional text clustering, we integrate medical domain-specific features to represent the messages posted in online health communities. Three disease discussion boards, including boards devoted to lung cancer, breast cancer and diabetes, from an online health community are used to test the effectiveness of topic detection. Experiment results demonstrate that health-related hot topics primarily include symptoms, examinations, drugs, procedures and complications. Further analysis reveals that there also exist some significant differences among the hot topics discussed on different types of disease discussion boards.

  6. Pre-Service Physics Teachers' Difficulties in Understanding Special Relativity Topics

    Science.gov (United States)

    Ünlü Yavas, Pervin; Kizilcik, Hasan Sahin

    2016-01-01

    The aim of this study is to identify the reasons why pre-service physics teachers have difficulties related to special relativity topics. In this study conducted with 25 pre-service physics teachers, the case study method, which is a qualitative research method, was used. Interviews were held with the participants about their reasons for…

  7. Identifying biological concepts from a protein-related corpus with a probabilistic topic model

    Directory of Open Access Journals (Sweden)

    Lu Xinghua

    2006-02-01

    Full Text Available Abstract Background Biomedical literature, e.g., MEDLINE, contains a wealth of knowledge regarding functions of proteins. Major recurring biological concepts within such text corpora represent the domains of this body of knowledge. The goal of this research is to identify the major biological topics/concepts from a corpus of protein-related MEDLINE© titles and abstracts by applying a probabilistic topic model. Results The latent Dirichlet allocation (LDA model was applied to the corpus. Based on the Bayesian model selection, 300 major topics were extracted from the corpus. The majority of identified topics/concepts was found to be semantically coherent and most represented biological objects or concepts. The identified topics/concepts were further mapped to the controlled vocabulary of the Gene Ontology (GO terms based on mutual information. Conclusion The major and recurring biological concepts within a collection of MEDLINE documents can be extracted by the LDA model. The identified topics/concepts provide parsimonious and semantically-enriched representation of the texts in a semantic space with reduced dimensionality and can be used to index text.

  8. Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: Protocol for an individual patient data meta-analysis

    OpenAIRE

    Persson, M.S.M. (Monica); Fu, Y. (Yu); Bhattacharya, A. (Archan); Goh, S.-L. (Siew-Li); Middelkoop, Marienke; Bierma-Zeinstra, Sita; Walsh, D. (David); Doherty, Michael; Zhang, Weiya

    2016-01-01

    Background Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical caps...

  9. Materials Characterization Center workshop on leaching mechanisms of nuclear waste forms, May 19-21, 1982, Gaithersburg, Maryland. Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Mendel, J.E. (comp.)

    1982-08-01

    This is a report of the second workshop on the leaching mechanism of nuclear waste forms, which was held at Geithersburg, Maryland, May 19-21, 1982. The first session of the workshop was devoted to progress reports by participants in the leaching mechanisms program. These progress reports, as prepared by the participants, are given in Section 3.0. The goal of the remainder of the workshop was to exchange information on the development of repository-relevant leach testing techniques, often called interactions testing. To this end, a wide spectrum of investigators, many of whose work is sponsored by DOE's Nuclear Waste Terminal Storage (NWTS) project, made presentations at the workshop. These presentations were a significant and beneficial part of the workshop and are summarized in Sections 4.0, 5.0 and 6.0 according to the workshop agenda topics. In many cases, the presenters provided a written version of their presentation which has been included verbatim; in the other cases, the workshop chairman has supplied a brief synopsis. Twenty-one papers have been abstracted and indexed for inclusion in the data base.

  10. Proceedings of the fourth workshop on radiative capture 1990, October 19--21, 1990

    International Nuclear Information System (INIS)

    Wender, S.A.; Gossett, C.; Feldman, J.

    1991-01-01

    The Fourth Workshop on Radiative Capture was held at the Berkeley Conference Center, Berkeley, CA, on October 19--21, 1990. This two-day workshop, which had seventeen presentations, addressed current theoretical and experimental issues in the field of nucleon capture and other nuclear radiative processes. The scientific program was divided into three sessions: (1) radiative capture at low energies; (2) few-nucleon systems and capture at intermediate energies; and (3) nucleon capture and other radiative processes. This proceedings of the conference contains the abstracts of the presented talks and the transparencies used by the speakers. Summary papers of the talks are also included when they were supplied by the speaker

  11. Difficulties are multiplying - topical legal issues relating to nuclear waste disposal

    International Nuclear Information System (INIS)

    Strassburg, W.

    1985-01-01

    The report points out topical legal issues relating to nuclear waste disposal, yet leaves no doubt that the technical-scientific concept for nuclear waste disposal incorporated into the nuclear energy law in 1976 was a success. Nonetheless it is desirable that there should be persistent efforts especially on the part of parliament when issuing legislation or statutory orders to reach greater clearness and thus predictability in areas where technology has been proven by many years of practice. (orig./HSCH) [de

  12. Atom probe field ion microscopy and related topics: A bibliography 1989

    International Nuclear Information System (INIS)

    Miller, M.K.; Hawkins, A.R.; Russell, K.F.

    1990-12-01

    This bibliography includes references related to the following topics: atom probe field ion microscopy (APFIM), field ion spectroscopy (FIM), field emission microscopy (FEM), liquid metal ion sources (LMIS), scanning tunneling microscopy (STM), and theory. Technique-orientated studies and applications are included. This bibliography covers the period 1989. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications

  13. Proceedings of first SWCR-KURRI academic seminar on research reactors and related research topics

    International Nuclear Information System (INIS)

    Kimura, Itsuro; Cong, Zhebao

    1986-01-01

    These are the proceedings of an academic seminar on research reactors and related research topics held at the Southwest Centre for Reactor Engineering Research and Design in Chengdu, Sichuan, People's Republic of China in September 24-26 in 1985. Included are the chairmen's addresses and 10 papers presented at the seminar in English. The titles of these papers are: (1) Nuclear Safety and Safeguards, (2) General Review of Thorium Research in Japanese Universities, (3) Comprehensive Utilization and Economic Analysis of the High Flux Engineering Test Reactor, (4) Present States of Applied Health Physics in Japan, (5) Neutron Radiography with Kyoto University Reactor, (6) Topics of Experimental Works with Kyoto University Reactor, (7) Integral Check of Nuclear Data for Reactor Structural Materials, (8) The Reactor Core, Physical Experiments and the Operation Safety Regulation of the Zero Energy Thermal Reactor for PWR Nuclear Power Plant, (9) HFETR Core Physical Parameters at Power, (10) Physical Consideration for Loads of Operated Ten Cycles in HFETR. (author)

  14. The Ricci flow part IV : long-time solutions and related topics

    CERN Document Server

    Chow, Bennett; Glickenstein, David; Isenberg, James

    2015-01-01

    Ricci flow is a powerful technique using a heat-type equation to deform Riemannian metrics on manifolds to better metrics in the search for geometric decompositions. With the fourth part of their volume on techniques and applications of the theory, the authors discuss long-time solutions of the Ricci flow and related topics. In dimension 3, Perelman completed Hamilton's program to prove Thurston's geometrization conjecture. In higher dimensions the Ricci flow has remarkable properties, which indicates its usefulness to understand relations between the geometry and topology of manifolds. This b

  15. Atom probe field ion microscopy and related topics: A bibliography 1993

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, R.D.; Miller, M.K.; Russell, K.F.

    1994-10-01

    This bibliography, covering the period 1993, includes references related to the following topics: atom probe field ion microscopy (APFIM), field emission (FE), and field ion microscopy (FIM). Technique-oriented studies and applications are included. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications. To reduce the length of this document, the references have been reduced to the minimum necessary to locate the articles. The references are listed alphabetically by authors, an Addendum of references missed in previous bibliographies is included.

  16. Earthquakes and associated topics in relation to nuclear power plant siting

    International Nuclear Information System (INIS)

    1991-01-01

    This Safety Guide was prepared as part of the Agency's programme for establishing Codes and Safety Guides relating to nuclear power plants. The main purpose of the text is to provide guidance on the determination of the design basis ground motions for a nuclear power plant at a chosen site and on the determination of the potential for surface faulting at that site. Additionally, the Guide discusses other permanent displacement phenomena (liquefaction, slope instability, subsidence and collapse) and introduces the topic of seismically induced flooding. Volcanic activity is not dealt with except in connection with tsunamis. 55 refs

  17. SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics

    International Nuclear Information System (INIS)

    Scheier, P.; Maerk, T.

    2002-01-01

    The XIII symposium on Atomic and Surface Physics and related Topics (SASP) is devoted to cover the research of interactions between ions, electrons, photons, atoms, molecules and clusters and their interaction with surfaces. This year there was a special session dedicated to proton transfer reaction mass spectrometry covering its applications in different fields and a mini symposium on the radiation action on bio-molecules such as uracil. The contributions included in the proceeding correspond to invited lectures and poster sessions, consisting of short and extended abstracts as well as short articles. (nevyjel)

  18. Atom probe field ion microscopy and related topics: A bibliography 1993

    International Nuclear Information System (INIS)

    Godfrey, R.D.; Miller, M.K.; Russell, K.F.

    1994-10-01

    This bibliography, covering the period 1993, includes references related to the following topics: atom probe field ion microscopy (APFIM), field emission (FE), and field ion microscopy (FIM). Technique-oriented studies and applications are included. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications. To reduce the length of this document, the references have been reduced to the minimum necessary to locate the articles. The references are listed alphabetically by authors, an Addendum of references missed in previous bibliographies is included

  19. SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics

    Energy Technology Data Exchange (ETDEWEB)

    Scheier, P; Maerk, T [eds.

    2002-07-01

    The XIII symposium on Atomic and Surface Physics and related Topics (SASP) is devoted to cover the research of interactions between ions, electrons, photons, atoms, molecules and clusters and their interaction with surfaces. This year there was a special session dedicated to proton transfer reaction mass spectrometry covering its applications in different fields and a mini symposium on the radiation action on bio-molecules such as uracil. The contributions included in the proceeding correspond to invited lectures and poster sessions, consisting of short and extended abstracts as well as short articles. (nevyjel)

  20. Culture-Related Topic Selection in Small Talk Conversations across Germany and Japan

    DEFF Research Database (Denmark)

    Endrass, Birgit; Nakano, Yukiko; Lipi, Afia Akhter

    2011-01-01

    Small talk can be used in order to build a positive relationship towards a virtual character. However the choice of topics in a conversation can be dependent on social backgrounds such as culture. In this paper, we explore culture-related differences in small talk for the German and Japanese...... cultures. Based on findings from the literature and verified by a corpus analysis, we integrated prototypical German and Japanese small talk conversations into a multiagent system. In evaluation studies conducted in the two target cultures, we investigated whether participants prefer agent dialogs...

  1. Phototoxicity and antipsoriatic effect of a topical methoxypsoralen solution in relation to the application time

    DEFF Research Database (Denmark)

    Meffert, H; Andersen, Klaus Ejner; Sönnichsen, N

    1984-01-01

    The phototoxicity and antipsoriatic activity of a topically applied 0.075% methoxypsoralen alcohol-glycerol solution was investigated in relation to the interval between drug application and irradiation. On healthy skin, maximum UVA sensitivity for erythema development appeared 40 to 60 min after...... the application of the methoxypsoralen solution, but in psoriatic plaques the antipsoriatic UVA sensitization reached its maximum after 10 to 20 min. This difference between induction of antipsoriatic effect and erythema sensitivity may be explained by rapid penetration of methoxypsoralen in psoriatic lesions...

  2. A new topical formulation enhances relative diclofenac bioavailability in healthy male subjects.

    Science.gov (United States)

    Brunner, Martin; Davies, David; Martin, Wolfgang; Leuratti, Chiara; Lackner, Edith; Müller, Markus

    2011-06-01

    • Therapy with topical non-steroidal anti-inflammatory drugs (NSAIDs) relies on the ability of the active drug to penetrate the skin in sufficiently high amounts to exert a clinical effect, which is linked to the specific galenic properties of the formulation. • This phase 1 study characterizes the transdermal penetration and plasma exposure of different dose levels with galenic differences of a novel topical diclofenac formulation under development and indicates greater diclofenac penetration through the skin when compared with a commercially available formulation. To evaluate the relative plasma and tissue availability of diclofenac after repeated topical administration of a novel diclofenac acid-based delivery system under development (DCF100C). This was a single-centre, open-label, three-period, crossover clinical trial of five discrete diclofenac formulations. Test preparations comprised two concentrations (1.0% and 2.5%) of DCF100C, with and without menthol and eucalyptus oil (total daily doses of 5 mg and 12.5 mg). Voltaren Emulgel gel (1.0%) was the commercially available comparator (total daily dose of 40 mg). Topical application was performed onto the thigh of 20 male healthy subjects for 3 days. Applying a Youden square design, each drug was evaluated in 12 subjects, with each subject receiving three test preparations. Blood sampling and in vivo microdialysis in subcutaneous adipose and skeletal muscle tissues were performed for 10 h after additional final doses on the morning of day 4. All four DCF100C formulations demonstrated a three- to fivefold, dose-dependent increase in systemic diclofenac availability compared with Voltaren Emulgel and were approximately 30-40 times more effective at facilitating diclofenac penetration through the skin, taking different dose levels into account. Tissue concentrations were low and highly variable. The 2.5% DCF100C formulation without sensory excipients reached the highest tissue concentrations. AUC(0,10 h) was

  3. A new topical formulation enhances relative diclofenac bioavailability in healthy male subjects

    Science.gov (United States)

    Brunner, Martin; Davies, David; Martin, Wolfgang; Leuratti, Chiara; Lackner, Edith; Müller, Markus

    2011-01-01

    AIMS To evaluate the relative plasma and tissue availability of diclofenac after repeated topical administration of a novel diclofenac acid-based delivery system under development (DCF100C). METHODS This was a single-centre, open-label, three-period, crossover clinical trial of five discrete diclofenac formulations. Test preparations comprised two concentrations (1.0% and 2.5%) of DCF100C, with and without menthol and eucalyptus oil (total daily doses of 5 mg and 12.5 mg). Voltaren® Emulgel® gel (1.0%) was the commercially available comparator (total daily dose of 40 mg). Topical application was performed onto the thigh of 20 male healthy subjects for 3 days. Applying a Youden square design, each drug was evaluated in 12 subjects, with each subject receiving three test preparations. Blood sampling and in vivo microdialysis in subcutaneous adipose and skeletal muscle tissues were performed for 10 h after additional final doses on the morning of day 4. RESULTS All four DCF100C formulations demonstrated a three- to fivefold, dose-dependent increase in systemic diclofenac availability compared with Voltaren® Emulgel® and were approximately 30–40 times more effective at facilitating diclofenac penetration through the skin, taking different dose levels into account. Tissue concentrations were low and highly variable. The 2.5% DCF100C formulation without sensory excipients reached the highest tissue concentrations. AUC(0,10 h) was 2.71 times greater than for Voltaren® Emulgel® (90% CI 99.27, 737.46%). Mild erythema at the application site was the most frequent adverse event associated with DCF100C. There were no local symptoms after treatment with the reference formulation. CONCLUSION DCF100C formulations were safe and facilitated greater diclofenac penetration through the skin compared with the commercial comparator. DCF100C represents a promising alternative to oral and topical diclofenac treatments that warrants further development. PMID:21241352

  4. Machine Learning-Based Classification of 38 Years of Spine-Related Literature Into 100 Research Topics.

    Science.gov (United States)

    Sing, David C; Metz, Lionel N; Dudli, Stefan

    2017-06-01

    Retrospective review. To identify the top 100 spine research topics. Recent advances in "machine learning," or computers learning without explicit instructions, have yielded broad technological advances. Topic modeling algorithms can be applied to large volumes of text to discover quantifiable themes and trends. Abstracts were extracted from the National Library of Medicine PubMed database from five prominent peer-reviewed spine journals (European Spine Journal [ESJ], The Spine Journal [SpineJ], Spine, Journal of Spinal Disorders and Techniques [JSDT], Journal of Neurosurgery: Spine [JNS]). Each abstract was entered into a latent Dirichlet allocation model specified to discover 100 topics, resulting in each abstract being assigned a probability of belonging in a topic. Topics were named using the five most frequently appearing terms within that topic. Significance of increasing ("hot") or decreasing ("cold") topic popularity over time was evaluated with simple linear regression. From 1978 to 2015, 25,805 spine-related research articles were extracted and classified into 100 topics. Top two most published topics included "clinical, surgeons, guidelines, information, care" (n = 496 articles) and "pain, back, low, treatment, chronic" (424). Top two hot trends included "disc, cervical, replacement, level, arthroplasty" (+0.05%/yr, P < 0.001), and "minimally, invasive, approach, technique" (+0.05%/yr, P < 0.001). By journal, the most published topics were ESJ-"operative, surgery, postoperative, underwent, preoperative"; SpineJ-"clinical, surgeons, guidelines, information, care"; Spine-"pain, back, low, treatment, chronic"; JNS- "tumor, lesions, rare, present, diagnosis"; JSDT-"cervical, anterior, plate, fusion, ACDF." Topics discovered through latent Dirichlet allocation modeling represent unbiased meaningful themes relevant to spine care. Topic dynamics can provide historical context and direction for future research for aspiring investigators and trainees

  5. An analysis of playing activity of 19-21-years-old footballers in the leading teams of Europe

    Directory of Open Access Journals (Sweden)

    Nikolaenko V.V.

    2012-11-01

    Full Text Available Competition activity of footballers of 19-21-years-old age in the professional commands of Europe on football is considered. Data for research serves the normatively-legal documents of football Federations of leading European championships (request folias and protocols of matches. It was attached the construction of the statistical grouping that in dynamic allow to analyze playing activity of footballers of 19-21-years-old age at the stage of preparation to the higher achievements. It is appraised the influence of the competition loading on the organism of sportsmen of this age. It is defined that participating of 19-21-years athletes in team of professional commands-leaders of UEFA rating. The necessity of research of psychophysiological and morphological characteristics of sportsmen of different playing lines in football, their usage in control and selection in professional teams were defined.

  6. Chapter F: Preliminary Bibliography of Lacustrine Diatomite Deposits in the Western United States and Related Topics

    Science.gov (United States)

    Bolm, Karen S.; Wallace, Alan R.; Moyle, Phillip R.; Bliss, James D.; Orris, Greta J.

    2003-01-01

    Introduction As part of the assessment of lacustrine diatomite resources in the Western United States (fig. 1), U.S. Geological Survey (USGS) project members conducted a review of literature relating to the formation, location, and nature of deposits in the study area. This preliminary bibliography consists of selected publications to identify, locate, and describe the deposits to be studied, to characterize common geologic factors about the deposits, and to better understand the factors that control their formation, preservation, or destruction. The bibliography also serves as a resource for other workers to research the topic. References included in the preliminary bibliography were gathered by searching existing bibliographic data bases and library collections. Project researchers also contributed references that they found during the course of their work. This bibliography should be considered a working document that will grow as research and literature searches continue. Clearly, many significant publications may be missing from this preliminary list; therefore, USGS staff members intend to issue a revised bibliography as project work progresses. To assure completeness, input from other researchers and industry is welcome. Although the focus of this bibliography is lacustrine diatomite deposits of the Western United States, additional references that provide a foundation of knowledge for the study of diatomites, diatoms, and diatom-related processes (ecology, geology, geochemistry) and for the uses and behavior of diatomite have also been included. An index of keywords has been added to this bibliography, designed to help the user locate reports by topic or by geographic location. The letter 'A' following a number indicates that the report referenced is an abstract.

  7. XXth international workshop on deep-inelastic scattering and related topics. DIS 2012. Proceedings

    International Nuclear Information System (INIS)

    Brock, Ian C.

    2013-03-01

    The following topics were dealt with: Structure functions, diffraction and vector mesons, electroweak interactions, hadronic final states, heavy flavours, spin physics, future of deep inelastic scattering. (HSI)

  8. XXth international workshop on deep-inelastic scattering and related topics. DIS 2012. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Brock, Ian C. [ed.

    2013-03-15

    The following topics were dealt with: Structure functions, diffraction and vector mesons, electroweak interactions, hadronic final states, heavy flavours, spin physics, future of deep inelastic scattering. (HSI)

  9. Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.

    Science.gov (United States)

    Wey, Pierre-François; Petitjeans, Fabrice; Lions, Christophe; Ould-Ahmed, Mehdi; Escarment, Jacques

    2008-08-01

    Bleeding is the most serious complication of oral anticoagulant therapy used for the prevention of thromboembolic complications. Drug-drug interactions are an important concern, as they may increase drug toxicity and, in the case of anticoagulant therapies, increase the risk of hemorrhage. An 84-year-old woman presented to the emergency department with a bilateral cervical hematoma and symptoms of upper-airway obstruction that had been increasing for 72 hours, with dyspnea and difficulty speaking developing in the previous 24 hours. Transnasal fiberoptic laryngoscopy revealed a significant laryngeal hematoma, as well as a hematoma on the floor of the mouth and in the tonsil area. Laboratory abnormalities included a prothrombin time 120 seconds. The patient had been receiving acenocoumarol 4 mg/d for 10 years for episodes of atrial fibrillation and recurrent deep venous thrombosis. Seventeen days earlier, she had received a prescription for topical econazole lotion 1% to be applied 3 times daily for 1 month to treat a dermatitis affecting 12% of the body surface. The patient was admitted to the intensive care unit for treatment of respiratory failure, where oxygen was delivered by face mask. The coagulation disorders were treated with prothrombin complex concentrate 30 IU/kg IV and vitamin K1 10 mg IV, and values normalized within 36 hours. Surgical evacuation of the laryngeal hematoma was not necessary. After 48 hours, improvement in the patient's respiratory symptoms allowed transfer to the ear, nose, and throat unit, where daily endoscopic examination was performed. Aspirin was substituted for acenocoumarol, and the patient returned home after 10 days without sequelae. Based on a Naranjo score of 7, this episode was probably related to an interaction between acenocoumarol and econazole. This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal

  10. A bibliography of stockwork molybdenite deposits and related topics (with an emphasis on the North American literature)

    Science.gov (United States)

    Steigerwald, Celia H.; Mutschler, Felix E.; Ludington, Steve

    1983-01-01

    This bibliography of 1117 citations brings together references on stockwork molybdenite deposits and related topics in a format that can be sorted by topic and(or) geographic area. Each reference is preceded by a key, or keys, which may be read and sorted visually or by computer, The bibliography is available in two formats: (1) paper- or microfiche-hardcopy, and (2) fixed format computer reasonable magnetic tape, A FORTRAN program is provided for sorting the magnetic tape version,

  11. The high latitude heliosphere. Proceedings. 28. ESLAB Symposium, Friedrichshafen (Germany), 19 - 21 Apr 1994.

    Science.gov (United States)

    Marsden, R. G.

    1995-04-01

    The following topics were dealt with: high latitude heliosphere, Ulysses mission, corona, spectra, coronal holes, composition, solar wind, He, plasma, streams, interplanetary magnetic field, plasma waves, radio bursts, energetic particles, cosmic rays, and interstellar gas.

  12. Atom probe field ion microscopy and related topics: A bibliography 1991

    International Nuclear Information System (INIS)

    Russell, K.F.; Miller, M.K.

    1993-01-01

    This report contains a bibliography for 1991 on the following topics: Atom probe field ion microscopy; field desorption mass spectrometry; field emission; field ion microscopy; and field emission theory

  13. Immunization update and hot topics in clinical immunology: how does this relate to my practice?

    Science.gov (United States)

    Bellanti, Joseph A

    2006-01-01

    The prevention of infectious diseases by the use of vaccines represents one of medicine's greatest triumphs during the 20th century. This era has witnessed the global eradication of smallpox as a result of Jennerian cowpox vaccination, the elimination of paralytic poliomyelitis from the western hemisphere, and within 5-10 years the anticipated eradication of poliomyelitis worldwide as a result of the poliovirus vaccines. Next slated for worldwide eradication is measles, the great killer of infants and children, which each year extracts a global mortality of one million victims. Throughout the 20th century the percutaneous (i.e., subcutaneous or intramuscular) route has almost exclusively been the preferred way to administer vaccines. However, as a result of several important scientific discoveries made during the 20th century, including new tissue-culturing techniques, the development of recombinant DNA technology, and genetic sequencing, a whole new generation of tailor-made modern vaccines has become available, including DNA vaccines and transgenic plant vaccines. Moreover, it became apparent that alternative routes of administration of vaccines, such as by aerosol immunization might be more appropriate and more effective than immunization via the parenteral route. The overall success in vaccine development, however, has not been without cost. For every new vaccine that has been developed, an adverse effect has been seen. Thus, although modern vaccines are extremely safe and effective, they are neither completely safe nor completely effective. The goal of vaccine development, therefore, is to achieve the highest degree of protection and the lowest rate of adverse effects. This paper describes some of the recent advances in vaccine development and will focus on some hot topics relating to the recent development and use of respiratory aerosolized vaccines.

  14. Taking the Silver Bullet Colloidal Silver Particles for the Topical Treatment of Biofilm-Related Infections.

    Science.gov (United States)

    Richter, Katharina; Facal, Paula; Thomas, Nicky; Vandecandelaere, Ilse; Ramezanpour, Mahnaz; Cooksley, Clare; Prestidge, Clive A; Coenye, Tom; Wormald, Peter-John; Vreugde, Sarah

    2017-07-05

    Biofilms are aggregates of bacteria residing in a self-assembled matrix, which protects these sessile cells against external stress, including antibiotic therapies. In light of emerging multidrug-resistant bacteria, alternative strategies to antibiotics are emerging. The present study evaluated the activity of colloidal silver nanoparticles (AgNPs) of different shapes against biofilms formed by Staphylococcus aureus (SA), methicillin-resistant SA (MRSA), and Pseudomonas aeruginosa (PA). Colloidal quasi-spherical, cubic, and star-shaped AgNPs were synthesized, and their cytotoxicity on macrophages (THP-1) and bronchial epithelial cells (Nuli-1) was analyzed by the lactate dehydrogenase assay. The antibiofilm activity was assessed in vitro by the resazurin assay and in an in vivo infection model in Caenorhabditis elegans. Cubic and star-shaped AgNPs induced cytotoxicity, while quasi-spherical AgNPs were not toxic. Quasi-spherical AgNPs showed substantial antibiofilm activity in vitro with 96% (±2%), 97% (±1%), and 98% (±1%) biofilm killing of SA, MRSA, and PA, respectively, while significantly reducing mortality of infected nematodes. The in vivo antibiofilm activity was linked to the accumulation of AgNPs in the intestinal tract of C. elegans as observed by 3D X-ray tomography. Quasi-spherical AgNPs were physically stable in suspension for over 6 months with no observed loss in antibiofilm activity. While toxicity and stability limited the utilization of cubic and star-shaped AgNPs, quasi-spherical AgNPs could be rapidly synthesized, were stable and nontoxic, and showed substantial in vitro and in vivo activity against clinically relevant biofilms. Quasi-spherical AgNPs hold potential as pharmacotherapy, for example, as topical treatment for biofilm-related infections.

  15. Secondary School Students' Knowledge and Opinions on Astrobiology Topics and Related Social Issues

    Science.gov (United States)

    Oreiro, Raquel; Solbes, Jordi

    2017-01-01

    Astrobiology is the study of the origin of life on Earth and the distribution of life in the Universe. Its multidisciplinary approach, social and philosophical implications, and appeal within the discipline and beyond make astrobiology a uniquely qualified subject for general science education. In this study, student knowledge and opinions on astrobiology topics were investigated. Eighty-nine students in their last year of compulsory education (age 15) completed a written questionnaire that consisted of 10 open questions on the topic of astrobiology. The results indicate that students have significant difficulties understanding the origin of life on Earth, despite exposure to the topic by way of the assigned textbooks. The students were often unaware of past or present achievements in the search for life within the Solar System and beyond, topics that are far less commonly seen in textbooks. Student questionnaire answers also indicated that students had problems in reasoning and critical thinking when asked for their opinions on issues such as the potential for life beyond Earth, the question of whether UFOs exist, or what our place is in the Universe. Astrobiology might help initiate student awareness as to current thinking on these matters and should be considered for general science education.

  16. Draft statement by the Watt Committee on Safety and related topics as respects nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-01

    The following topics are examined, with particular reference to nuclear power: the nature of risk; waste disposal to the environment (ecological damage and radiation damage due to nuclear plants and fossil-fuel plants); the benefits of nuclear power (including discussion of the following matters: need to conserve fossil fuels; safety; and possibility of diversion to nuclear weapons).

  17. Secondary School Students' Knowledge and Opinions on Astrobiology Topics and Related Social Issues.

    Science.gov (United States)

    Oreiro, Raquel; Solbes, Jordi

    2017-01-01

    Astrobiology is the study of the origin of life on Earth and the distribution of life in the Universe. Its multidisciplinary approach, social and philosophical implications, and appeal within the discipline and beyond make astrobiology a uniquely qualified subject for general science education. In this study, student knowledge and opinions on astrobiology topics were investigated. Eighty-nine students in their last year of compulsory education (age 15) completed a written questionnaire that consisted of 10 open questions on the topic of astrobiology. The results indicate that students have significant difficulties understanding the origin of life on Earth, despite exposure to the topic by way of the assigned textbooks. The students were often unaware of past or present achievements in the search for life within the Solar System and beyond, topics that are far less commonly seen in textbooks. Student questionnaire answers also indicated that students had problems in reasoning and critical thinking when asked for their opinions on issues such as the potential for life beyond Earth, the question of whether UFOs exist, or what our place is in the Universe. Astrobiology might help initiate student awareness as to current thinking on these matters and should be considered for general science education. Key Words: Astrobiology-Students' views-Science education. Astrobiology 17, 91-99.

  18. Secondary School Students' Knowledge and Opinions on Astrobiology Topics and Related Social Issues

    OpenAIRE

    Oreiro Rey, Raquel; Solbes Matarredona, Jordi

    2017-01-01

    Astrobiology is the study of the origin of life on Earth and the distribution of life in the Universe. Its multidisciplinary approach, social and philosophical implications, and appeal within the discipline and beyond make astrobiology a uniquely qualified subject for general science education. In this study, student knowledge and opinions on astrobiology topics were investigated. Eighty-nine students in their last year of compulsory education (age 15) completed a written questionnaire that c...

  19. (Theory of weak interactions and related topics; and study of e sup + e sup minus interactions)

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Lay Nam; Tze, C.H.

    1990-01-01

    This report contains brief discussions on the following topics: Higher point anomalous amplitudes; topological phase of quantum gravity; chiral symmetry breaking at finite temperature; Skyrmions as representations of current algebras; D {ge} 4 critical phenomena: self-duality, infinite dimensional symmetries and hypercomplex analyticity; D {ge} 3 topological field theories: anionic membranes and division algebras, geometric quantization by the method of orbits; and novel non-perturbative approaches. (LSP)

  20. [Theory of weak interactions and related topics; and study of e+e- interactions

    International Nuclear Information System (INIS)

    Chang, Lay Nam; Tze, C.H.

    1990-01-01

    This report contains brief discussions on the following topics: Higher point anomalous amplitudes; topological phase of quantum gravity; chiral symmetry breaking at finite temperature; Skyrmions as representations of current algebras; D ≥ 4 critical phenomena: self-duality, infinite dimensional symmetries and hypercomplex analyticity; D ≥ 3 topological field theories: anionic membranes and division algebras, geometric quantization by the method of orbits; and novel non-perturbative approaches

  1. The Effect of Topical Rosa damascena (Rose) Oil on Pregnancy-Related Low Back Pain: A Randomized Controlled Clinical Trial.

    Science.gov (United States)

    Shirazi, Mahbobeh; Mohebitabar, Safieh; Bioos, Sodabeh; Yekaninejad, Mir Saeed; Rahimi, Roja; Shahpiri, Zahra; Malekshahi, Farhad; Nejatbakhsh, Fatemeh

    2017-01-01

    The study aimed to assess the efficacy of topical rose oil in women with pregnancy-related low back pain. A randomized controlled clinical trial was conducted on 120 women with pregnancy-related low back pain. Patients were allocated to 3 parallel groups to receive topical rose oil (in the carrier of almond oil), placebo (carrier oil), or no intervention. All groups were followed for 4 weeks. All participants were evaluated by Visual Analog Scale and the Roland-Morris Disability Questionnaires to assess the pain intensity and its impact on daily activities before and after the intervention. Significant decrease in pain intensity compared to carrier oil or no intervention was observed. The rose oil also improves the functional ability of these patients in contrast with no intervention, while its effect on function is not significant compared to carrier oil. Rose oil reduced pregnancy-related low back pain intensity without any significant adverse effect. © The Author(s) 2016.

  2. Large truncated Toeplitz matrices, Toeplitz operators, and related topics the Albrecht Böttcher anniversary volume

    CERN Document Server

    Ehrhardt, Torsten; Karlovich, Alexei; Spitkovsky, Ilya

    2017-01-01

    This book presents a collection of expository and research papers on various topics in matrix and operator theory, contributed by several experts on the occasion of Albrecht Böttcher’s 60th birthday. Albrecht Böttcher himself has made substantial contributions to the subject in the past. The book also includes a biographical essay, a complete bibliography of Albrecht Böttcher’s work and brief informal notes on personal encounters with him. The book is of interest to graduate and advanced undergraduate students majoring in mathematics, researchers in matrix and operator theory as well as engineers and applied mathematicians.

  3. Infrared sensors and sensor fusion; Proceedings of the Meeting, Orlando, FL, May 19-21, 1987

    International Nuclear Information System (INIS)

    Buser, R.G.; Warren, F.B.

    1987-01-01

    The present conference discusses topics in the fields of IR sensor multifunctional design; image modeling, simulation, and detection; IR sensor configurations and components; thermal sensor arrays; silicide-based IR sensors; and IR focal plane array utilization. Attention is given to the fusion of lidar and FLIR for target segmentation and enhancement, the synergetic integration of thermal and visual images for computer vision, the 'Falcon Eye' FLIR system, multifunctional electrooptics and multiaperture sensors for precision-guided munitions, and AI approaches to data integration. Also discussed are the comparative performance of Ir silicide and Pt silicide photodiodes, high fill-factor silicide monolithic arrays, and the characterization of noise in staring IR focal plane arrays

  4. Bioequivalence of diclofenac sodium 2% and 1.5% topical solutions relative to oral diclofenac sodium in healthy volunteers.

    Science.gov (United States)

    Holt, Robert J; Taiwo, Tolu; Kent, Jeffrey D

    2015-08-01

    Topical formulations of nonsteroidal anti-inflammatory drugs (NSAIDs) are generally considered to be safer alternatives to oral NSAIDs due to lower systemic absorption. We conducted randomized, crossover studies that compared the pharmacokinetics (PK), bioequivalence and safety of topical diclofenac sodium 2% twice daily (BID), diclofenac sodium 1.5% four times daily (QID) and oral diclofenac sodium in healthy subjects. The results of three bioequivalence studies are reviewed. Healthy adult subjects (n = 76) applied topical diclofenac sodium 2% solution (40.4 mg/2 mL) BID; or 1.5% solution (19.3 mg/40 drops) QID to each knee for 7.5 consecutive days separated by a washout period. Subjects (n = 22) in one study also received oral diclofenac sodium 75 mg BID for 7.5 days. Plasma diclofenac concentrations were determined from serial blood samples collected on Days 1 and 8 (steady state), and diclofenac PK parameters were estimated by noncompartmental methods. The studies demonstrated comparable bioequivalence between the 2% and 1.5% topical solutions as well as lower systemic exposure compared to oral dosing (approximately 93% less). Daily systemic exposure was comparable between the two formulations with only a 12% difference in the AUCss(0-24) (p = 0.140). Furthermore, both topical solutions demonstrated delayed elimination with a t(1/2) of 4- to 6-fold longer, as compared to oral diclofenac. The 2% solution provided more consistent dosing relative to the 1.5% solution when comparing AUCss(0-24) and Cmaxss across studies. Mild application site reactions were the most common treatment-emergent adverse event reported with topical diclofenac. The steady-state PK profile of topical diclofenac 2% solution administered BID is similar to that of the 1.5% solution administered QID. Systemic exposure to diclofenac is substantially lower after topical application as compared to oral administration. (Study 2 was registered with ClinicalTrials.gov; NCT01202799; https

  5. NATO Advanced Research Workshop on Approximation by Solutions of Partial Differential Equations, Quadrature Formulae, and Related Topics

    CERN Document Server

    Goldstein, M; Haussmann, W; Hayman, W; Rogge, L

    1992-01-01

    This volume consists of the proceedings of the NATO Advanced Research Workshop on Approximation by Solutions of Partial Differential Equations, Quadrature Formulae, and Related Topics, which was held at Hanstholm, Denmark. These proceedings include the main invited talks and contributed papers given during the workshop. The aim of these lectures was to present a selection of results of the latest research in the field. In addition to covering topics in approximation by solutions of partial differential equations and quadrature formulae, this volume is also concerned with related areas, such as Gaussian quadratures, the Pompelu problem, rational approximation to the Fresnel integral, boundary correspondence of univalent harmonic mappings, the application of the Hilbert transform in two dimensional aerodynamics, finely open sets in the limit set of a finitely generated Kleinian group, scattering theory, harmonic and maximal measures for rational functions and the solution of the classical Dirichlet problem. In ...

  6. Communicating with children and families about obesity and weight-related topics: a scoping review of best practices.

    Science.gov (United States)

    McPherson, A C; Hamilton, J; Kingsnorth, S; Knibbe, T J; Peters, M; Swift, J A; Krog, K; Chen, L; Steinberg, A; Ball, G D C

    2017-02-01

    Healthcare professionals have called for direction on how best to communicate about weight-related topics with children and families. Established scoping review methodology was used to answer the question: 'How can healthcare professionals best communicate with children and their families about obesity and weight-related topics?' We searched four scientific databases, two grey literature repositories and 14 key journals (2005-2016). Inclusion criteria were (i) children up to and including 18 years of age and/or their parents; (ii) communication about healthy weight, overweight, obesity or healthy/active living; and (iii) healthcare setting. Thirty-two articles were included. Evidence-based best practices were largely absent from the literature, although the following guiding principles were identified: (i) include all stakeholders in discussions; (ii) raise the topic of weight and health early and regularly; (iii) use strengths-based language emphasizing health over weight; (iv) use collaborative goal-setting to engage children and parents and (v) augment discussions with appropriate tools and resources. Guidance on how to implement these principles and how to negotiate relevant contextual factors (e.g. age, culture and disability) is still needed. Despite agreement on a number of guiding principles, evidence-based weight-related communication best practices are lacking. Rigorous, empirical evaluations of communication approaches are urgently required, especially those that include children's perspectives. © 2016 World Obesity Federation.

  7. Proceedings of the Topical Sessions on Media Relations held in June 2004 and 2005

    International Nuclear Information System (INIS)

    2006-01-01

    An effective media strategy, including timely interaction with them is an indispensable tool for organisations or institutions involved in radioactive waste management. With this in mind, the Forum on Stakeholder Confidence (FSC) set up a Group on Communication and Outreach with a twofold objective: to assist FSC members in communicating with the radioactive waste management community, to assist FSC members in reaching a broader public. As part of this assignment, the Group organised two Topical Sessions on media strategy, in conjunction with the 2004 and 2005 FSC meetings. The main objective was to learn about the functioning of the media organisations, their structures and needs, with speakers chosen to represent the range of such media, as well as different countries and varying radioactive waste situations that may serve as illustrative examples, given the vast differences that may prevail between local, national, and international radioactive waste management situations and their treatment by the media. The sessions were attended by representatives of policy makers, regulators and implementers from the FSC organisations. The presentations and discussions illustrated current media strategies, best practices, successes and failures and lessons learn. These proceedings consist of a summary of the main points made by each speaker as well a collation of their papers

  8. Cross sections for inelastic scattering of electrons by atoms: selected topics related to electron microscopy

    International Nuclear Information System (INIS)

    Inokuti, M.; Manson, S.T.

    1982-01-01

    We begin with a resume of the Bethe theory, which provides a general framework for discussing the inelastic scattering of fast electrons and leads to powerful criteria for judging the reliability of cross-section data. The central notion of the theory is the generalized oscillator strength as a function of both the energy transfer and the momentum transfer, and is the only non-trivial factor in the inelastic-scattering cross section. Although the Bethe theory was initially conceived for free atoms, its basic ideas apply to solids, with suitable generalizations; in this respect, the notion of the dielectric response function is the most fundamental. Topics selected for discussion include the generalized oscillator strengths for the K-shell and L-shell ionization for all atoms with Z less than or equal to 30, evaluated by use of the Hartree-Slater potential. As a function of the energy transfer, the generalized oscillator strength most often shows a non-monotonic structure near the K-shell and L-shell thresholds, which has been interpreted as manifestations of electron-wave propagation through atomic fields. For molecules and solids, there are additional structures due to the scattering of ejected electrons by the fields of other atoms

  9. Sixth meeting of the ITPA Topical Group on Diagnostics

    International Nuclear Information System (INIS)

    Donne, A.J.H.; Costley, A.E.

    2004-01-01

    The Sixth Meeting of the International Tokamak Physics Activities (ITPA) Topical Group (TG) on Diagnostics was held at JAERI, Naka from 19-21 February 2004. This meeting was combined with a Progress Meeting on ITER/BPX (burning plasma experiment) relevant diagnostic developments on-going in Japan. For the first time, ITPA members from China, as well as observers from South Korea, attended. In addition, an associated sub-meeting was held at General Atomics, San Diego, 23-24 April, immediately after the 15th Topical Conference on High Temperature Plasma Diagnostics. At the sub-meeting a special one-day session was devoted to issues related to beam-aided spectroscopy. In total more than 50 participants attended the meetings and all ITER partners were represented. The key topics reviewed and discussed at the TG meeting were: (i) the overall status of diagnostics developments for ITER, (ii) the progress in the research on the designated high priority topics, (iii) the progress with some key ITER/BPX-relevant diagnostic developments ongoing in the ITPA participant laboratories, (iv) the progress and plans for the work of the specialist working groups, (v) the status and plans for the International Diagnostic Database

  10. Physics and Chemistry of the Interstellar Medium. General Colloquium, 19-21 November 2012, Paris

    International Nuclear Information System (INIS)

    Aguillon, Francois; Alata, Ivan; Alcaraz, Christian; Alves, Marta; Andre, Philippe; Bachiller, Rafael; Bacmann, Aurore; Baklouti, Donia; Bernard, Jean-Philippe; Berne, Olivier; Beroff, Karine; Bertin, Mathieu; Biennier, Ludovic; Bocchio, Marco; Bonal, Lydie; Bontemps, Sylvain; Bouchez Giret, Aurelia; Boulanger, Francois; Bracco, Andrea; Bron, Emeric; Brunetto, Rosario; Cabrit, Sylvie; Canosa, Andre; Capron, Michael; Ceccarelli, Cecilia; Cernicharo, Jose; Chaabouni, Henda; Chabot, Marin; Chen, Hui-Chen; Chiavassa, Thierry; Cobut, Vincent; Commercon, Benoit; Congiu, Emanuele; Coutens, Audrey; Danger, Gregoire; Daniel, Fabien; Dartois, Emmanuel; Demyk, Karine; Denis, Alpizar; Despois, Didier; D'hendecourt, Louis; Dontot, Leo; Doronin, Mikhail; Dubernet, Marie-Lise; Dulieu, Francois; Dumouchel, Fabien; Duvernay, Fabrice; Ellinger, Yves; Falgarone, Edith; Falvo, Cyril; Faure, Alexandre; Fayolle, Edith; Feautrier, Nicole; Feraud, Geraldine; Fillion, Jean-Hugues; Gamboa, Antonio; Gardez, Aline; Gavilan, Lisseth; Gerin, Maryvonne; Ghesquiere, Pierre; Godard, Benjamin; Godard, Marie; Gounelle, Matthieu; Gratier, Pierre; Grenier, Isabelle; Gruet, Sebastien; Gry, Cecile; Guillemin, Jean-Claude; Guilloteau, Stephane; Gusdorf, Antoine; Guzman, Viviana; Habart, Emilie; Hennebelle, Patrick; Herrera, Cinthya; Hily-Blant, Pierre; Hincelin, Ugo; Hochlaf, Majdi; Huet, Therese; Iftner, Christophe; Jallat, Aurelie; Joblin, Christine; Kahane, Claudine; Kalugina, Yulia; Kleiner, Isabelle; Koehler, Melanie; Kokkin, Damian; Koutroumpa, Dimitra; Krim, Lahouari; Lallement, Rosine; Lanza, Mathieu; Lattelais, Marie; Le Bertre, Thibaut; Le Gal, Romane; Le Petit, Franck; Le Picard, Sebastien; Lefloch, Bertrand; Lemaire, Jean Louis; Lesaffre, Pierre; Lique, Francois; Loison, Jean-Christophe; Lopez Sepulcre, Ana; Maillard, Jean-Pierre; Margules, Laurent; Martin, Celine; Mascetti, Joelle; Michaut, Xavier; Minissale, Marco; Miville-Deschenes, Marc-Antoine; Mokrane, Hakima; Momferratos, Georgios; Montillaud, Julien; Montmerle, Thierry; Moret-Bailly, Jacques; Motiyenko, Roman; Moudens, Audrey; Noble, Jennifer; Padovani, Marco; Pagani, Laurent; Pardanaud, Cedric; Parisel, Olivier; Pauzat, Francoise; Pernet, Amelie; Pety, Jerome; Philippe, Laurent; Piergiorgio, Casavecchia; Pilme, Julien; Pinto, Cecilia; Pirali, Olivier; Pirim, Claire; Puspitarini, Lucky; Rist, Claire; Ristorcelli, Isabelle; Romanzin, Claire; Roueff, Evelyne; Rousseau, Patrick; Sabbah, Hassan; Saury, Eleonore; Schneider, Ioan; Schwell, Martin; Sims, Ian; Spielfiedel, Annie; Stoecklin, Thierry; Talbi, Dahbia; Taquet, Vianney; Teillet-Billy, Dominique; Theule, Patrice; Thi, Wing-Fai; Trolez, Yann; Valdivia, Valeska; Van Dishoeck, Ewine; Verstraete, Laurent; Vinogradoff, Vassilissa; Wiesenfeld, Laurent; Ysard, Nathalie; Yvart, Walter; Zicler Eleonore

    2012-11-01

    This document publishes the oral contributions and the 66 posters presented during a colloquium on physics and chemistry of interstellar medium. The following themes have been addressed: New views on the interstellar medium with Herschel, Planck and Alma, Cycle of interstellar dusts, Physics and Dynamics of the interstellar medium, Molecular complexifying and the link towards pre-biotic chemistry. More precisely, the oral contributions addressed the following topics: Interstellar medium with Herschel and Planck; The anomalous microwave emission: a new window on the physics of small grains; Sub-millimetre spectroscopy of complex molecules and of radicals for ALMA and Herschel missions; Analysing observations of molecules in the ISM: theoretical and experimental studies of energy transfer; Unravelling the labyrinth of star formation with Herschel; Star formation regions with Herschel and Alma: astro-chemistry in the Netherlands; Physical structure of gas and dust in photo-dissociation regions observed with Herschel; Photo-desorption of analogues of interstellar ices; Formation of structures in the interstellar medium: theoretical and numerical aspects; Towards a 3D mapping of the galactic ISM by inversion of absorption individual measurements; Low velocity shocks as signatures of turbulent dissipation in diffuse irradiated gas; Early phases of solar system formation: 3D physical and chemical modelling of the collapse of pre-stellar dense core; Cosmic-ray propagation in molecular clouds; Protostellar shocks in the time of Herschel; A new PDR model of the physics and chemistry of the interstellar gas; Molecular spectroscopy in the ALMA era and laboratory Astrophysics in Spain; Which molecules to be searched for in the interstellar medium; Physics and chemistry of UV illuminated neutral gas: the Horsehead case; Nitrogen fractionation in dark clouds; Molecular spectral surveys from millimetre range to far infrared; Mechanisms and synthesis at the surface of cold grains

  11. Teacher- or Learner-Centred? Science Teacher Beliefs Related to Topic Specific Pedagogical Content Knowledge: A South African Case Study

    Science.gov (United States)

    Mavhunga, Elizabeth; Rollnick, Marissa

    2016-12-01

    In science education, learner-centred classroom practices are widely accepted as desirable and are associated with responsive and reformed kinds of teacher beliefs. They are further associated with high-quality Pedagogical Content Knowledge (PCK). Topic-Specific Pedagogical Content Knowledge (TSPCK), a version of PCK defined at topic level, is known to enable the transformation of topic content into a form accessible to learners. However, little is known about teacher science beliefs in relation to TSPCK and therefore the nature of likely associated classroom practices. In this study, we investigated the relationship between TSPCK and underlying science teacher beliefs following an intervention targeting the improvement of TSPCK in the topic chemical equilibrium. Sixteen final year pre-service chemistry teachers were exposed to an intervention that explicitly focussed on knowledge for transforming the content of chemical equilibrium using the five knowledge components of TSPCK. A specially designed TSPCK instrument in chemical equilibrium and the Teacher Belief Instrument (TBI) were used to capture written responses in pre- and post-tests. Additional qualitative data was collected from audio-recorded discussions and written responses from an open-ended question asked before and after the intervention. Two key findings emerged from the study. Firstly, the development of TSPCK was linked to shifts in underlying science teacher beliefs in the direction of learner-centred teaching for the majority of pre-service teachers. Secondly, this shift was not evident for all, as for some there was development of TSPCK without a shift from teacher-centred beliefs about science teaching.

  12. Regulatory Information By Topic

    Science.gov (United States)

    EPA develops and enforces regulations that span many environmental topics, from acid rain reduction to wetlands restoration. Each topic listed below may include related laws and regulations, compliance enforcement information, policies guidance

  13. Google Trends terms reporting rhinitis and related topics differ in European countries

    DEFF Research Database (Denmark)

    Bousquet, J.; Agache, I; Anto, J M

    2017-01-01

    Google Trends (GT) searches trends of specific queries in Google and reflects the real-life epidemiology of allergic rhinitis. We compared Google Trends terms related to allergy and rhinitis in all European Union countries, Norway and Switzerland from 1 January 2011 to 20 December 2016. The aim w...

  14. Topics of differential geometry in hamiltonian and lagrangian mechanics and relativity

    International Nuclear Information System (INIS)

    Rodrigues, P.R.

    1982-01-01

    A little introduction to the tensor and exterior algebra just as to the differential geometry is made. Such a geometry is used in order to study the hamiltonian and lagrangian mechanics stressing their geometrical aspects. Some applications are done in relativity theory. (L.C.) [pt

  15. Topical issues of psychological research materials on matters related to extremism

    Directory of Open Access Journals (Sweden)

    Sekerazh T.N.

    2014-12-01

    Full Text Available The article deals with methodological support psychological and linguistic research "extremist" materials. Presents a comprehensive psycho-linguistic approach to the examination of information materials on matters related to combating extremism and terrorism, and certain provisions of the methodology developed by the Russian federal center of judicial examination of the Ministry of Justice of the Russian Federation. Based on the analysis of the "verbal" crimes related to criminal legal interpretation of extremism and terrorism, highlighted the types of prohibited public expression of communicative action, corresponding to the seven types of "extremist" values. The article outlines the key features of psychological analysis "extremist" materials research stages. It is shown that the complex (psycho-linguistic approach to the study of materials of extremist orientation, is scientifically sound, methodically proven, appropriate to the needs of law enforcement, judicial and investigative practice.

  16. Theory of weak interactions and related topics. Progress report, January 1-December 31, 1981

    International Nuclear Information System (INIS)

    Marshak, R.E.

    1985-08-01

    The research program demonstrated that the acceptance of B-L local symmetry as the weak hypercharge, whose spontaneous breakdown was connected to the spontaneous breakdown of parity, predicted a light electron neutrino (Majorana) and a related heavy neutrino. The prediction of neutron oscillations following from the PUT group SU(4)/sub C/ x SU(2)/sub L/ x SU(2)/sub R/ was scrutinized. A relation was derived between the mixing time for free neutron oscillations and the lifetime for nuclear stability with respect to ΔB = 2 transitions, and a study was conducted of the effect of time-varying or spatial-varying magnetic fields on the mixing time of neutron oscillations. Reasons are given for continuing work with the left-right symmetry (LRS) and partial unification theory (PUT) groups to their grand unification realization. It was shown that, without assuming a simple GUT group, that the color group has to be SU(3) and that the only possible GUT groups are SU(5) and SU(10). The gauge boson mass relation was derived for arbitrary Higgs structure associated either with the standard SU(2)/sub L/ x U(1) electroweak group or the LRS group. Also examined was the Pati-Salam type of grand unification. 31 refs

  17. Topics relating to atomic collisions in dilute Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Roberts, David C.

    2002-01-01

    In this thesis, we investigate various aspects of applications and limitations arising from atomic collisions in dilute Bose-Einstein condensates. First, we investigate the relative particle number squeezing produced in the excited states of a dilute condensate at zero temperature using stimulated light scattering. We show that a modest number of relative number squeezed particles can be achieved when atoms, produced in pairs through collisions in the condensate, are scattered out by their interaction with the lasers. This squeezing is optimal when the momentum is larger than the inverse healing length. This modest number of relative number squeezed particles has the potential to be amplified in four-wave-mixing experiments. We study the limitations on the relative number squeezing between photons and atoms coupled out from a homogeneous Bose-Einstein condensate. We consider the coupling between the translational atomic states by two photon Bragg processes, one of the photon modes involved in the Bragg process being in a coherent state, and the other initially unpopulated. We start with an interacting condensate at zero temperature and compute the time evolution for the system. We discuss how collisions between the atoms and photon rescattering affect the degree of squeezing which may be reached in such experiments. We investigate the limitations arising from atomic collisions on the storage and delay times of probe pulses in EIT experiments. We find that the atomic collisions can be described by an effective decay rate that limits storage and delay times. We calculate the momentum and temperature dependence of the decay rate and find that it is necessary to excite atoms to a particular momentum depending on temperature and spacing of the energy levels involved in order to minimize the decoherence effects of atomic collisions. Finally, we propose a method to probe states in the Mott insulator regime produced from a condensate in an optical lattice. We consider a

  18. Google Trends terms reporting rhinitis and related topics differ in European countries.

    Science.gov (United States)

    Bousquet, J; Agache, I; Anto, J M; Bergmann, K C; Bachert, C; Annesi-Maesano, I; Bousquet, P J; D'Amato, G; Demoly, P; De Vries, G; Eller, E; Fokkens, W J; Fonseca, J; Haahtela, T; Hellings, P W; Just, J; Keil, T; Klimek, L; Kuna, P; Lodrup Carlsen, K C; Mösges, R; Murray, R; Nekam, K; Onorato, G; Papadopoulos, N G; Samolinski, B; Schmid-Grendelmeier, P; Thibaudon, M; Tomazic, P; Triggiani, M; Valiulis, A; Valovirta, E; Van Eerd, M; Wickman, M; Zuberbier, T; Sheikh, A

    2017-08-01

    Google Trends (GT) searches trends of specific queries in Google and reflects the real-life epidemiology of allergic rhinitis. We compared Google Trends terms related to allergy and rhinitis in all European Union countries, Norway and Switzerland from 1 January 2011 to 20 December 2016. The aim was to assess whether the same terms could be used to report the seasonal variations of allergic diseases. Using the Google Trend 5-year graph, an annual and clear seasonality of queries was found in all countries apart from Cyprus, Estonia, Latvia, Lithuania and Malta. Different terms were found to demonstrate seasonality depending on the country - namely 'hay fever', 'allergy' and 'pollen' - showing cultural differences. A single set of terms cannot be used across all European countries, but allergy seasonality can be compared across Europe providing the above three terms are used. Using longitudinal data in different countries and multiple terms, we identified an awareness-related spike of searches (December 2016). © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Utilization of radiation facilities at TNRC for shielding researches and related topics

    Energy Technology Data Exchange (ETDEWEB)

    Akki, T S [Physics Department, Nuclear Physics and Radiation Shielding Division Tajura Nuclear Research Center, Tripoli (Libyan Arab Jamahiriya)

    1997-12-31

    This paper presents the running shielding research activities at Tajura Nuclear research center. The main area of researches are concentrated on the investigation of different types of concrete made from local materials such as conventional concrete, Magnetite-Limonite concrete, and heat resistant concrete. The measuring techniques used were neutron-gamma spectrometry, and activation foils. The measurements were performed using collimated beam of reactor neutrons emitted from one of the horizontal channels, as well as from californium-252 neutron source. The transmitted neutron spectra through concrete barriers of different thicknesses were measured by a scintillation spectrometer with NE-213 liquid organic scintillator. A non-destructive testing of some reactor materials were also carried out using neutron and gamma ray computerized tomography technique (CT). Some experiments were also carried out related to measurements of neutron depth dose distributions inside tissue equivalent materials. 10 figs.

  20. Analysis of the pion-kaon sigma term and related topics

    International Nuclear Information System (INIS)

    Frink, M.; Kubis, B.; Meissner, U.G.

    2002-01-01

    We calculate the one-loop contributions to the difference Δ πK between the isoscalar on-shell pion-kaon scattering amplitude at the Cheng-Dashen point and the scalar form factor Γ K (2M 2 π ) in the framework of three flavor chiral perturbation theory. These corrections turn out to be small. This is further sharpened by treating the kaons as heavy fields (two flavor chiral perturbation theory). We also analyze the two-loop corrections to the kaon scalar form factor based on a dispersive technique. We find that these corrections are smaller than in the comparable case of the scalar form factor of the pion. This is related to the weaker final state interactions in the pion-kaon channel. (orig.)

  1. Analysis of the pion-kaon sigma term and related topics

    Energy Technology Data Exchange (ETDEWEB)

    Frink, M.; Kubis, B.; Meissner, U.G. [Forschungszentrum Juelich, Institut fuer Kernphysik (Theorie), Juelich (Germany)

    2002-09-01

    We calculate the one-loop contributions to the difference {delta}{sub {pi}}{sub K} between the isoscalar on-shell pion-kaon scattering amplitude at the Cheng-Dashen point and the scalar form factor {gamma}{sub K} (2M{sup 2}{sub {pi}}) in the framework of three flavor chiral perturbation theory. These corrections turn out to be small. This is further sharpened by treating the kaons as heavy fields (two flavor chiral perturbation theory). We also analyze the two-loop corrections to the kaon scalar form factor based on a dispersive technique. We find that these corrections are smaller than in the comparable case of the scalar form factor of the pion. This is related to the weaker final state interactions in the pion-kaon channel. (orig.)

  2. Study of Ionospheric Indexes T and MF2 related to R12 for Solar Cycles 19-21

    Science.gov (United States)

    Villanueva, Lucia

    2013-04-01

    Modern worldwide communications are mainly based on satellite systems, remote communication networks, and advanced technologies. The most important space weather "meteorological" events produce negative effects on signal transmissions. Magnetic storm conditions that follow coronal mass ejections are particularly of great importance for radio communication at HF frequencies (3-30 MHz range), because the Ionization increase (or decrease), significantly over (or below), the Average Values. Nowadays new technologies make possible to establish Geophysical Observatories and monitor the sun almost in real time giving information about geomagnetic indices. Space Weather programs have interesting software predictions of foF2 producing maps and plots, every some minutes. The Average Values of the ionospheric parameters mainly depend on the position, hour, season and the phase of the 11-year cycle of the solar activity. Around 1990´s several ionospheric indexes were suggested to better predict the state of the foF2 monthly media, as: IF2, G, T and MF2, based on foF2 data from different latitude ionospheric observatories. They really show better seasonal changes than monthly solar indexes of solar flux F10.7 or the international sunspot numbers Ri. The main purpose of this paper is to present an analogic model for the ionospheric index MF2, to establish the average long term predictions of this index. Changes of phase from one cycle to the other of one component of the model is found to fit the data. The usefulness of this model could be the prediction of the ionospheric normal conditions for one entire solar cycle having just the prediction of the maximum of the next smooth sunspot number R12. In this presentation, comparisons of the Australian T index and and the Mikhailov MF2 index show an hysteresis variation with the solar monthly index Ri, such dependence is quite well represented by a polynomial fit of degree 6 for rising and decaying fases for solar cycles 19, 20 and 21.

  3. Topics in LIGO-related physics: Interferometric speed meters and tidal work

    Science.gov (United States)

    Purdue, Patricia Marie

    In the quest to develop viable designs for third-generation interferometric gravitational-wave detectors (such as the Laser Interferometer Gravitational-Wave Observatory, LIGO), one strategy is monitoring the relative momentum or speed of the test-mass mirrors, rather than monitoring their relative position. The most straightforward design for a speed-meter interferometer that accomplishes this is analyzed in Chapter 2. It is shown that in principle this design can beat the standard quantum limit (SQL) by an arbitrarily large amount, over an arbitrarily wide range of frequencies. However, in practice, this specific speed meter requires exorbitantly high input light power. Chapter 3 proposes a more sophisticated version of a speed meter. This new design requires modest input power and appears to be a fully practical candidate for third-generation detectors. It can beat the SQL over a broad range of frequencies (˜10 to 100 Hz in practice) by a factor h/hSQL ˜ WSQLcirc/Wc irc . Here Wcirc is the light power circulating in the interferometer arms and WSQL ≃ 800 kW is the circulating power required to beat the SQL at 100 Hz. If squeezed vacuum (with a power-squeeze factor e-2 R) is injected into the interferometer's output port, the SQL can be beat with less laser power: h/h SQL ˜ WSQLcirc/Wc irce2R . For realistic parameters (e2 R ≃ 10 and Wcirc ≃ 800 kW), the SQL can be beat by a factor ˜3 from 10 to 100 Hz. By performing frequency-dependent homodyne detection on the output (using two kilometer-scale filter cavities), one can markedly improve the interferometer's sensitivity at frequencies above 100 Hz. Chapter 4 is a contribution to the foundations for analyzing sources of gravitational waves. Specifically, it presents an analysis of the tidal work done on a self-gravitating body in an external tidal field. By examining the change in the mass-energy of the body as a result of the tidal field, it is shown that the work done is gauge invariant, while the body

  4. Theory of weak interactions and related topics. Progress report, January 1-December 31, 1980

    International Nuclear Information System (INIS)

    Marshak, R.E.

    1985-08-01

    The work reported included an effort to understand the physical meaning of the U(1) hypercharge group in the accepted electroweak SU/sub L/(2) x U(1) group, as well as other facets of the electroweak structure (e.g., the persistence of the V-A charged current despite the finite masses of the quarks and leptons, the meaning of quark-lepton symmetry for all three generations). It was shown that, unlike the case of the SU(2)/sub L/ x U(1) model, the vector U(1) generator in the SU(2)/sub L/ x SU(2)/sub R/ x U(1) model can be identified with (B-L) symmetry. Consequences were explored of the idea that the breakdown of parity is related to the non-conservation of global B-L. One consequence is that two Majorana neutrinos, one light and one extremely heavy, are predicted for each generation. Also examined were the questions of the magnitudes of various B-violating amplitudes and the kinds of selection rules governing these processes. 18 refs

  5. Proceedings of the workshop on small angle scattering data analysis. Micelle related topics

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, Toshio [Fukuoka Univ. (Japan). Faculty of Science; Furusaka, Michihiro; Ohtomo, Toshiya [eds.

    1996-02-01

    This workshop was held on December 13 and 14, 1995 at National Laboratory for High Energy Physics. At the workshop, the purpose of the workshop was explained, and lectures were given on the research on superhigh molecular structure by small angle neutron scattering, the verification of the reliability of WINK data (absolute intensity), the analysis of WINK data, the new data program of SAN, small angle X-ray scattering data analysis program (SAXS), the basis of the analysis of micelle system, analysis software manual and practice program Q-I(Q) ver 1.0, various analysis methods for small angle scattering and contrast modulation method and others, the ordering of and the countermeasures to the problems of WINK, and the hereafter of KENS small angle scattering facility. How to treat the analysis related to micelle, how to save WINK and how to install the SAN/reflectometer are the matters to be discussed at the workshop. In this book, the summaries of the lectures are collected. (K.I.)

  6. Evaluation of Energy-Related Inventions Program: An Empirical Analysis of 204 Inventions; TOPICAL

    International Nuclear Information System (INIS)

    Brown, M.A.

    1987-01-01

    This report is an evaluation of the Energy-Related Inventions Program (ERIP). It assess the program's effectiveness and impacts, characterizes participating inventions and inventors, and identifies correlates of successful commercialization in order to suggest possible improvements. Seventy of the 204 ERIP inventions that were studied were successfully introduced into the market, accounting for more than$200M in sales from 1976 through 1984. During 1984, 921 full-time equivalent employees were supported directly by ERIP inventors or their licensees. (Estimates of indirect economic impacts are also contained in the report.) Data on patterns of fund raising clearly show a need for assistance by programs like ERIP. Commercially successful inventors shared several traits. They had less formal education, fewer patents, more work experience in small firms, more outside funding early in their work, more shared responsibility with others for invention development, more management experience, and greater previous experience with starting new businesses. Recommendations are made regarding: (1) priorities for allocating ERIP grants; (2) improved efficiency of the NBS/DOE operations; (3) delivery of technical and commercialization assistance to grant recipients; and (4) further evaluation research

  7. Prevalence of Topical Corticosteroids Related Adverse Drug Events and Associated Factors in Selected Community Pharmacies and Cosmetic Shops of Addis Ababa, Ethiopia

    Directory of Open Access Journals (Sweden)

    Mahlet Tsegaye

    2018-03-01

    Conclusion: Majority of the topical corticosteroids were obtained without prescription for the purpose of beautification rather than treatment. A higher proportion of cosmetic users reported to have experienced at least one adverse event. There needs to consider safety concerns related to topical corticosteroids use in the city.

  8. Matrix Results and Techniques in Quantum Information Science and Related Topics

    Science.gov (United States)

    Pelejo, Diane Christine

    In this dissertation, we present several matrix-related problems and results motivated by quantum information theory. Some background material of quantum information science will be discussed in chapter 1, while chapter 7 gives a summary of results and concluding remarks. In chapter 2, we look at 2n x 2 n unitary matrices, which describe operations on a closed n-qubit system. We define a set of simple quantum gates, called controlled single qubit gates, and their associated operational cost. We then present a recurrence scheme to decompose a general 2n x 2n unitary matrix to the product of no more than 2n-12n-1 single qubit gates with small number of controls. In chapter 3, we address the problem of finding a specific element phi among a given set of quantum channels S that will produce the optimal value of a scalar function D(rho 1,phi(rho2)), on two fixed quantum states rho 1 and rho2. Some of the functions we considered for D(·,·) are the trace distance, quantum fidelity and quantum relative entropy. We discuss the optimal solution when S is the set of unitary quantum channels, the set of mixed unitary channels, the set of unital quantum channels, and the set of all quantum channels. In chapter 4, we focus on the spectral properties of qubit-qudit bipartite states with a maximally mixed qudit subsystem. More specifically, given positive numbers a1 ≥ ... ≥ a 2n ≥ 0, we want to determine if there exist a 2n x 2n density matrix rho having eigenvalues a1,..., a2n and satisfying tr 1(rho)=1/n In. This problem is a special case of the more general quantum marginal problem. We give the minimal necessary and sufficient conditions on a1,..., a2n for n ≤ 6 and state some observations on general values of n.. In chapter 5, we discuss the numerical method of alternating projections and illustrate its usefulness in: (a) constructing a quantum channel, if it exists, such that phi(rho(1))=sigma(1),...,phi(rho (k))=sigma(k) for given rho (1),...,rho(k) ∈ Dn and

  9. Freshman Health Topics

    Science.gov (United States)

    Hovde, Karen

    2011-01-01

    This article examines a cluster of health topics that are frequently selected by students in lower division classes. Topics address issues relating to addictive substances, including alcohol and tobacco, eating disorders, obesity, and dieting. Analysis of the topics examines their interrelationships and organization in the reference literature.…

  10. Volcanoes and associated topics in relation to nuclear power plant siting

    International Nuclear Information System (INIS)

    1997-01-01

    assessment, as required in Section 5. Guidance related to some of the subjects covered in this report can be found in Safety Guides Nos 50-SG-S 1 (Rev. 1), 50-SG-S5, 50-SG-S8 and 50-SG-S 10A

  11. ISINN-5. 5. International seminar on interaction of neutrons with nuclei. Neutron spectroscopy, nuclear structure, related topics

    International Nuclear Information System (INIS)

    1997-01-01

    The materials submitted at the fifth in a series of annual international seminar on interaction of neutrons with nuclei Neutron Spectroscopy, Nuclear Structure, Related Topics (ISINN-5) are given. The Seminar is organized by the Frank Laboratory of Neutron Physics of the Joint Institute for Nuclear Research and took place in Dubna on May 14-17, 1997. About 130 specialists from Belgium, China, Germany, France, Japan, Korea, Latvia, Netherlands, Ukraine, 7 Russian research institutes and a number of JINR laboratories took part in the Seminar. The scope of the problems discussed is traditionally wide. It includes the problems of violation of fundamental symmetries in the interaction of neutrons with nuclei, the properties of the neutron as the fundamental particle, nonstatistical aspects of the radiation capture of neutrons by nuclei, topical problems of the theory of nucleus, and the fission mechanism of heavy nuclei. The latest results obtained with ultracold neutrons (UCN), in particular, different approaches to understanding of the cause of UCN anomalous leakage through the walls of the trap are considered as well. The wide spectrum of methodological aspects of neutron-aided experiments is also discussed in details

  12. Syntacticized topics in Kurmuk

    DEFF Research Database (Denmark)

    Andersen, Torben

    2015-01-01

    This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct....... The grammatical relation of the topic is expressed by a voice-like inflection of the verb, here called orientation. While subject-orientation is morphologically unmarked, object-oriented and adjunct-oriented verbs are marked by a subject suffix or by a suffix indicating that the topic is not subject, and adjunct......-orientation differs from object-orientation by a marked tone pattern. Topic choice largely reflects information structure by indicating topic continuity. The topic also plays a crucial role in relative clauses and in clauses with contrastive constituent focus, in that objects and adjuncts can only be relativized...

  13. Analysis of playing activity of footballers 19-21-years-old age in the leading commands of Europe.

    Directory of Open Access Journals (Sweden)

    Nikolaenko V.V.

    2012-10-01

    Full Text Available Competition activity of footballers is considered 19-21-years-old age in the professional commands of Europe. For research it was served as information normatively-legal documents of Federations of football of leading European championships (request letters and protocols of matches. In research it was necessary to be attached to the construction of the statistical groupings, that allowed to analyse in a dynamics playing activity of footballers on the stage of training to higher achievements. Influence of the competition loadings is appraised on the organism of sportsmen. Participating of sportsmen of this age is set in compositions of professional commands - leaders of rating of UEFA. It is set that the basic failing in preparation of the Ukrainian young footballers is surplus pursuit after a result and accent on physical preparation. It gives advantage above other commands which work above the technique of game (Holland, Germany, Spain in youth football. However, when players from youth football pass to the grown man, results sharply fall and felt substantial blanks in individual technical preparedness.

  14. Advancing TVET for Youth Employability and Sustainable Development. Promising Practices in TVET and Entrepreneurship Education in the Arab States (Beirut, Lebanon, November 19-21, 2013). Meeting Report

    Science.gov (United States)

    Sulieman, Sulieman, Comp.; Freiburg, Lisa, Comp.; Newashi, Qasem, Comp.

    2013-01-01

    UNESCO-UNEVOC and UNESCO Regional Bureau, Beirut, in cooperation with the Ministry of Education and Higher Education, Lebanon (General Directorate for Vocational and Technical Education, GDVTE, and Center for Educational Research and Development, CERD), organized a three-day Regional Expert Meeting (Beirut, 19-21 November 2013) as a platform for…

  15. Testosterone Topical

    Science.gov (United States)

    ... not apply any testosterone topical products to your penis or scrotum or to skin that has sores, ... are severe or do not go away: breast enlargement and/or pain decreased sexual desire acne depression ...

  16. Enhancing student performance in introductory physics in topics related to electricity and magnetism through the use of voluntary workshops

    Science.gov (United States)

    DeSilva, L. Ajith; Pullen, Adam; Hasbun, J. E.

    2018-05-01

    This article examines the effect of voluntary workshops on students’ performance in a university for algebra-based introductory physics on the topics of electricity, magnetism and related areas. A workshop is an optional one-hour-per-week session that promotes a small group’s peer instruction and co-operative learning, in order to enhance the conceptual understanding of physical principles and to improve problem-solving skills. During the workshops, a small group of students were encouraged to exchange ideas in a co-operative learning environment. Most students enrolled were poorly motivated, underprepared, and did not possess the prerequisite mathematics needed. For those who attended workshops, the result of scores on a standardized conceptual survey in electricity and magnetism showed a pre-test-post-test gain of 21% in the number of correct responses. This is to be contrasted with a 5% increase for those students who did not attend workshops. Further, we present a breakdown of the final letter grades obtained by students who attended workshops versus those who did not. Since the introduction of the workshops (out of 374 students), 95% of those who attended made a ‘C’ or better in the course. This compares to only 50% of the students who did not attend workshops and making a ‘C’ or better. The workshops have been offered since the Fall of 2010, but analyzed data includes fourteen years of student letter grades from 2001 to 2014 in order to study the effects on the workshops of the D, F, or W grades (DFW rate). We report a 7% reduction of the DFW rates, which we attribute to the incorporation of the workshops. The workshops are easy to implement and relatively inexpensive, yet appear to be an effective instructional method that enhances the success of underprepared students.

  17. How Readability and Topic Incidence Relate to Performance on Mathematics Story Problems in Computer-Based Curricula

    Science.gov (United States)

    Walkington, Candace; Clinton, Virginia; Ritter, Steven N.; Nathan, Mitchell J.

    2015-01-01

    Solving mathematics story problems requires text comprehension skills. However, previous studies have found few connections between traditional measures of text readability and performance on story problems. We hypothesized that recently developed measures of readability and topic incidence measured by text-mining tools may illuminate associations…

  18. Review of Priority Research & Development Topics: R&D related to the use of Remote Sensing in National Forest Monitoring

    NARCIS (Netherlands)

    Mitchell, A.; Hoekman, D.H.

    2014-01-01

    This document reviews the potential of the various remote sensing-derived forest map products that can be used in implementing and improving national forest monitoring systems8 and help meet the requirements of the IPCC Guidelines. It identifies any research and development topics that need to be

  19. Bimatoprost Topical

    Science.gov (United States)

    ... not use a cotton swab or any other brush or applicator to apply topical bimatoprost.To use the solution, follow these steps: Wash your hands and face thoroughly with soap and water. Be sure that all makeup is removed. Do not let the tip of ...

  20. Topic Modeling of Smoking- and Cessation-Related Posts to the American Cancer Society's Cancer Survivor Network (CSN): Implications for Cessation Treatment for Cancer Survivors Who Smoke.

    Science.gov (United States)

    Westmaas, J Lee; McDonald, Bennett R; Portier, Kenneth M

    2017-08-01

    Smoking is a risk factor in at least 18 cancers, and approximately two-thirds of cancer survivors continue smoking following diagnosis. Text mining of survivors' online posts related to smoking and quitting could inform strategies to reduce smoking in this vulnerable population. We identified posts containing smoking/cessation-related keywords from the Cancer Survivors Network (CSN), an online cancer survivor community of 166 000 members and over 468 000 posts since inception. Unsupervised topic model analysis of posts since 2000 using Latent Dirichlet Allocation extracted 70 latent topics which two subject experts inspected for themes based on representative terms. Posterior analysis assessed the distribution of topics within posts, and the range of themes discussed across posts. Less than 1% of posts (n = 3998) contained smoking/cessation-related terms, and covered topics related to cancer diagnoses, treatments, and coping. The most frequent smoking-related topics were quit smoking methods (5.4% of posts), and the environment for quitters (2.9% of posts), such as the stigma associated with being a smoker diagnosed with cancer and lack of empathy experienced compared to nonsmokers. Smoking as a risk factor for one's diagnosis was a primary topic in only 1.7% of smoking/cessation-related posts. The low frequency of smoking/cessation-related posts may be due to expected criticism/stigma for smoking but may also suggests a need for health care providers to address smoking and assist with quitting in the diagnostic and treatment process. Topic model analysis revealed potential barriers that should be addressed in devising clinical or population-level interventions for cancer survivors who smoke. Although smoking is a major risk factor for cancer, little is known about cancer patients' or survivors' views or concerns about smoking and quitting. This study used text mining of posts to an online community of cancer patients and survivors to investigate contexts in which

  1. Associations of Topics of Discussion on Twitter With Survey Measures of Attitudes, Knowledge, and Behaviors Related to Zika: Probabilistic Study in the United States.

    Science.gov (United States)

    Farhadloo, Mohsen; Winneg, Kenneth; Chan, Man-Pui Sally; Hall Jamieson, Kathleen; Albarracin, Dolores

    2018-02-09

    Recent outbreaks of Zika virus around the world led to increased discussions about this issue on social media platforms such as Twitter. These discussions may provide useful information about attitudes, knowledge, and behaviors of the population regarding issues that are important for public policy. We sought to identify the associations of the topics of discussions on Twitter and survey measures of Zika-related attitudes, knowledge, and behaviors, not solely based upon the volume of such discussions but by analyzing the content of conversations using probabilistic techniques. Using probabilistic topic modeling with US county and week as the unit of analysis, we analyzed the content of Twitter online communications to identify topics related to the reported attitudes, knowledge, and behaviors captured in a national representative survey (N=33,193) of the US adult population over 33 weeks. Our analyses revealed topics related to "congress funding for Zika," "microcephaly," "Zika-related travel discussions," "insect repellent," "blood transfusion technology," and "Zika in Miami" were associated with our survey measures of attitudes, knowledge, and behaviors observed over the period of the study. Our results demonstrated that it is possible to uncover topics of discussions from Twitter communications that are associated with the Zika-related attitudes, knowledge, and behaviors of populations over time. Social media data can be used as a complementary source of information alongside traditional data sources to gauge the patterns of attitudes, knowledge, and behaviors in a population. ©Mohsen Farhadloo, Kenneth Winneg, Man-Pui Sally Chan, Kathleen Hall Jamieson, Dolores Albarracin. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 09.02.2018.

  2. Associations of Topics of Discussion on Twitter With Survey Measures of Attitudes, Knowledge, and Behaviors Related to Zika: Probabilistic Study in the United States

    Science.gov (United States)

    Winneg, Kenneth; Chan, Man-Pui Sally; Hall Jamieson, Kathleen; Albarracin, Dolores

    2018-01-01

    Background Recent outbreaks of Zika virus around the world led to increased discussions about this issue on social media platforms such as Twitter. These discussions may provide useful information about attitudes, knowledge, and behaviors of the population regarding issues that are important for public policy. Objective We sought to identify the associations of the topics of discussions on Twitter and survey measures of Zika-related attitudes, knowledge, and behaviors, not solely based upon the volume of such discussions but by analyzing the content of conversations using probabilistic techniques. Methods Using probabilistic topic modeling with US county and week as the unit of analysis, we analyzed the content of Twitter online communications to identify topics related to the reported attitudes, knowledge, and behaviors captured in a national representative survey (N=33,193) of the US adult population over 33 weeks. Results Our analyses revealed topics related to “congress funding for Zika,” “microcephaly,” “Zika-related travel discussions,” “insect repellent,” “blood transfusion technology,” and “Zika in Miami” were associated with our survey measures of attitudes, knowledge, and behaviors observed over the period of the study. Conclusions Our results demonstrated that it is possible to uncover topics of discussions from Twitter communications that are associated with the Zika-related attitudes, knowledge, and behaviors of populations over time. Social media data can be used as a complementary source of information alongside traditional data sources to gauge the patterns of attitudes, knowledge, and behaviors in a population. PMID:29426815

  3. Topical anesthesia

    Directory of Open Access Journals (Sweden)

    Mritunjay Kumar

    2015-01-01

    Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

  4. Symbiosis: Rich, Exciting, Neglected Topic

    Science.gov (United States)

    Rowland, Jane Thomas

    1974-01-01

    Argues that the topic of symbiosis has been greatly neglected and underemphasized in general-biology textbooks. Discusses many types and examples of symbiosis, and provides an extensive bibliography of the literature related to this topic. (JR)

  5. A Study of the Subject Categorization of the MIS-related Journals in the ISI Databases Using Topical Features in the Text Content and Machine Learning Methods

    Directory of Open Access Journals (Sweden)

    Sung-Chien Lin

    2015-07-01

    Full Text Available In this study we analyzed and discussed that the MIS-related journals under the ISI subject category of IS&LS are simultaneously given with subject category Management, using methods of topic modeling, journal clustering and subject category prediction. In the experiment of journal clustering, all journals under subject category Management and other journals also having similar topical features can be gathered into a cluster, and “management” is their common and the most distinct topic. Because the journals belonged to this cluster are almost same to those in the MIS clusters generated by the previous studies, we considered it as the MIS cluster in this study. In the second experiment, we used the classification and regression tree (CART technique to predict assignment of subject category with that the journals in the original subject category Management and in the MIS cluster produced in this study as positive examples, respectively. The trees generated by the two tests both used the occurring probabilities of the topic “management” as the main classification rule. However, in the latter test, we did not only obtain a simpler classification tree but also had a result with less predicting errors. This means that if all journals in the MIS cluster could be given with subject category Management, the retrieval results can be more effective and complete.

  6. [Topics on Which Relatives of Persons with Dementia Seek Counseling Over Telephone or Email: Current Results of a Nationwide Counseling Service of the German Alzheimer Society].

    Science.gov (United States)

    Pendergrass, Anna; Weiß, Saskia; Gräßel, Elmar

    2018-04-19

    Since 15 years, the Alzheimer 's Telephone of the German Alzheimer Society (Deutsche Alzheimer Gesellschaft e.V.; DAlzG), a nationwide psychosocial counseling service, has been offering support for people with dementia (PwD) and their families. The aim of this study was to evaluate: a) why informal PwD caregivers seek telephone counseling, b) whether these telephone calls are one-time counseling or long-term support, and c) whether the telephone inquiries differ from the email-based inquiries with regard to the addressed issues. The data are based on the inquiries of 3,744 informal caregivers, which consulted the DAlzG in 2015. Sociodemographic data on the informal caregivers and the PwD, the characteristics of the telephone call, and the topics addressed in the email inquiries were collected. 70.3% of the callers were female. Most of them (59.9%) were the children (in-law) of and half of them (49.7%) lived with PwD. More than two-thirds of the callers (70%) were seeking help in dealing with the person with dementia (e. g. challenging behavior) and 36.5% of the relatives needed recommendations for further local help and assistance. In the third place, the calls were related to financial and legal topics (23.5%). 92.2% of the calls were one-time consultations. The addressed issues in the email inquiries did not significantly differ from the topics discussed over the telephone. On many topics there is a need for further "on site" consultation. Doctors and other health professionals should therefore be actively involved in counseling relatives of PwD. © Georg Thieme Verlag KG Stuttgart · New York.

  7. Nuclear safety - Topical issues

    International Nuclear Information System (INIS)

    1995-01-01

    The following topical issues related to nuclear safety are discussed: steam generators; maintenance strategies; control rod drive nozzle cracks; core shrouds cracks; sump strainer blockage; fire protection; computer software important for safety; safety during shutdown; operational safety experience; external hazards and other site related issues. 5 figs, 5 tabs

  8. Proceedings of the international symposium on safety related measurements in PWRs: Topic of the first meeting: 'Temperature and level measurements'

    International Nuclear Information System (INIS)

    2001-09-01

    Numerous teams of experts from several countries deal with theme of measurement important for safety operation of WWER reactors. These special teams have a need to meet at various opportunities to change their experience. As an example I can mention meeting of experts from Russia , Germany, France and Slovakia at completion and reconstruction of Slovak NPP, at modernisation of Russian and Bulgarian NPP. Mentioned meetings have invoked an idea of participants to organise a common action aimed at measurement important for safety operation of WWER, that participants can change their experience from mentioned area at welcome environment of symposium. Therefore, at meeting of experts from Siemens, INCOR and VUJE at the end of the year 2000 participants agreed on realisation of such common action. Participants have taken orientation at all safety measurements for very deep topic. Therefore, they have decided in respect of this first meeting of symposium to give consideration to only some special measurements in particular to temperature and surface. In case of interest there is possible to take focus at other type of measurements. Slovakia has been chosen for the first meeting place on basis of economic reasons and also because a number of improvements of standard reactor temperature measuring procedures have been implemented here that over passed its frontiers. In addition the first fail-safe level measuring in reactor pressure vessel has been effectuated in Slovakia

  9. Proper balance of omega-3 and omega-6 fatty acid supplements with topical cyclosporine attenuated contact lens-related dry eye syndrome.

    Science.gov (United States)

    Wang, Ling; Chen, Xi; Hao, Jingfang; Yang, Lu

    2016-12-01

    Essential fatty acids had been applied in the treatment of dry eye syndrome (DES), but the effects of different combinations of fatty acids have not been investigated. 360 long-term contact lens wearers were included in this double-blinded study. Omega-3 and omega-6 fatty acids were combined in different ratios and supplied to the participants that were randomly divided into six groups, and the effects of different essential fatty acids mixture on DES with or without topical cyclosporine were investigated. More than half of long-term contact lens wearers suffered from DES, which were found to be attenuated by oral supplement of properly balanced O3FA and O6FA fatty acid. The topical cyclosporine treatment considerably inhibited the production of cytokines compared to the cyclosporine negative groups, which further relieved DES. Proper balance of omega-3 and omega-6 fatty acid combination significantly alleviated contact lens-related DES.

  10. Using hot lab to increase pre-service physics teacher’s critical thinking skills related to the topic of RLC circuit

    Science.gov (United States)

    Malik, A.; Setiawan, A.; Suhandi, A.; Permanasari, A.; Samsudin, A.; Safitri, D.; Lisdiani, S. A. S.; Sapriadil, S.; Hermita, N.

    2018-05-01

    This research purposes to explore the used of Higher Order Thinking Laboratory (HOT-Lab) in enhancing the critical thinking skills of pre-service teachers related to the topic of Resistors, Inductors, Capacitor (RLC circuit). This study utilised a quasi-experiment method with Pretest-Posttest Control Group design. The sample of the study was 60 students that were divided into two groups covering in experiment and control group, consists of 30 students. The instrument for measuring critical thinking skills is essay test. Data has been analyzed using normalized gain average, effect size, and t-test. The results show that students’ critical thinking skills using the HOT Lab are higher than the verification lab. Using HOT-lab was implemented in the form of activity in the laboratory can improve high-order thinking skills. Hence, it was concluded that the use of HOT Lab had a greater impact on improving students’ critical thinking skills on RLC topic. Finally, HOT Lab can be used for other physics topics.

  11. 76 FR 41217 - Technical Inputs and Assessment Capacity on Topics Related to 2013 U.S. National Climate Assessment

    Science.gov (United States)

    2011-07-13

    ... resources, transportation, human health and welfare, human social systems, and biological diversity; and 3. Analyzes current trends in global change, both human-induced and natural, and projects major trends for the... perspectives, especially as they relate to the value of climate and global change information for decision...

  12. Topical Research: Africa.

    Science.gov (United States)

    Lynn, Karen

    This lesson plan can be used in social studies, language arts, or library research. The instructional objective is for students to select a topic of study relating to Africa, write a thesis statement, collect information from media sources, and develop a conclusion. The teacher may assign the lesson for written or oral evaluation. The teacher…

  13. A Statistical Model and Computer program for Preliminary Calculations Related to the Scaling of Sensor Arrays; TOPICAL

    International Nuclear Information System (INIS)

    Max Morris

    2001-01-01

    Recent advances in sensor technology and engineering have made it possible to assemble many related sensors in a common array, often of small physical size. Sensor arrays may report an entire vector of measured values in each data collection cycle, typically one value per sensor per sampling time. The larger quantities of data provided by larger arrays certainly contain more information, however in some cases experience suggests that dramatic increases in array size do not always lead to corresponding improvements in the practical value of the data. The work leading to this report was motivated by the need to develop computational planning tools to approximate the relative effectiveness of arrays of different size (or scale) in a wide variety of contexts. The basis of the work is a statistical model of a generic sensor array. It includes features representing measurement error, both common to all sensors and independent from sensor to sensor, and the stochastic relationships between the quantities to be measured by the sensors. The model can be used to assess the effectiveness of hypothetical arrays in classifying objects or events from two classes. A computer program is presented for evaluating the misclassification rates which can be expected when arrays are calibrated using a given number of training samples, or the number of training samples required to attain a given level of classification accuracy. The program is also available via email from the first author for a limited time

  14. A Call to Action: Setting the Research Agenda for Addressing Obesity and Weight-Related Topics in Children with Physical Disabilities.

    Science.gov (United States)

    McPherson, Amy C; Ball, Geoff D C; Maltais, Désirée B; Swift, Judy A; Cairney, John; Knibbe, Tara Joy; Krog, Kim

    2016-02-01

    Pediatric obesity is a world-wide challenge. Children with physical disabilities are particularly at risk of obesity, which is worrisome because obesity can result in serious secondary conditions that decrease health status, reduce independence, and increase impact on healthcare systems. However, the determinants of obesity and the health promotion needs of children with physical disabilities are relatively unexplored compared with their typically developing peers. This white paper describes a Canadian multi-stakeholder workshop on the topic of obesity and health in children with physical disabilities and provides recommendations for future research in this understudied area. Seventy-one knowledge gaps identified by attendees using a modified nominal group technique clustered into six themes: (1) early, sustained engagement of families; (2) rethinking determinants of obesity and health; (3) maximizing impact of research; (4) inclusive integrated interventions; (5) evidence-informed measurement and outcomes; and (6) reducing weight biases. Attendees worked together to develop research plans in more detail for three areas identified through consensus as high priority: "early, sustained engagement of families;" "rethinking determinants of obesity and health;" and "evidence informed measurement and outcomes." Using the workshop described here as a call to action, Canadian researchers are now well positioned to work toward a greater understanding of weight-related topics in children with physical disabilities, with the aim of developing evidence-based and salient obesity prevention and treatment approaches.

  15. Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains

    Directory of Open Access Journals (Sweden)

    Christine Rohde

    2018-04-01

    Full Text Available Phage therapy is increasingly put forward as a “new” potential tool in the fight against antibiotic resistant infections. During the “Centennial Celebration of Bacteriophage Research” conference in Tbilisi, Georgia on 26–29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as policy makers, officials of the competent authorities for medicines, phage researchers and phage producers, and members of the pharmaceutical industry. This brief also points out potential avenues for future phage therapy research and development as it specifically addresses those overarching questions that currently call for attention whenever phages go into purification processes for application.

  16. Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice.

    Directory of Open Access Journals (Sweden)

    Neera Tewari-Singh

    Full Text Available To identify effective therapies against sulfur mustard (SM-induced skin injuries, various animals have been used to assess the cutaneous pathology and related histopathological changes of SM injuries. However, these efforts to establish relevant skin injury endpoints for efficacy studies have been limited mainly due to the restricted assess of SM. Therefore, we employed the SM analog nitrogen mustard (NM, a primary vesicating and bifunctional alkylating agent, to establish relevant endpoints for efficient efficacy studies. Our published studies show that NM (3.2 mg exposure for 12-120 h in both the hairless SKH-1 and haired C57BL/6 mice caused clinical sequelae of toxicity similar to SM exposure in humans. The NM-induced cutaneous pathology-related structural changes were further analyzed in this study and quantified morphometrically (as percent length or area of epidermis or dermis of skin sections in mice showing these lesions. H&E stained skin sections of both hairless and haired mice showed that NM (12-120 h exposure caused epidermal histopathological effects such as increased epidermal thickness, epidermal-dermal separation, necrotic/dead epidermis, epidermal denuding, scab formation, parakeratosis (24-120 h, hyperkeratosis (12-120 h, and acanthosis with hyperplasia (72-120 h. Similar NM exposure in both mice caused dermal changes including necrosis, edema, increase in inflammatory cells, and red blood cell extravasation. These NM-induced cutaneous histopathological features are comparable to the reported lesions from SM exposure in humans and animal models. This study advocates the usefulness of these histopathological parameters observed due to NM exposure in screening and optimization of rescue therapies against NM and SM skin injuries.

  17. Lead Research and Development Activity for DOE's High Temperature, Low Relative Humidity Membrane Program (Topic 2)

    Energy Technology Data Exchange (ETDEWEB)

    James Fenton, PhD; Darlene Slattery, PhD; Nahid Mohajeri, PhD

    2012-09-05

    The Department of Energy’s High Temperature, Low Relative Humidity Membrane Program was begun in 2006 with the Florida Solar Energy Center (FSEC) as the lead organization. During the first three years of the program, FSEC was tasked with developing non-Nafion® proton exchange membranes with improved conductivity for fuel cells. Additionally, FSEC was responsible for developing protocols for the measurement of in-plane conductivity, providing conductivity measurements for the other funded teams, developing a method for through-plane conductivity and organizing and holding semiannual meetings of the High Temperature Membrane Working Group (HTMWG). The FSEC membrane research focused on the development of supported poly[perfluorosulfonic acid] (PFSA) – Teflon membranes and a hydrocarbon membrane, sulfonated poly(ether ether ketone). The fourth generation of the PFSA membrane (designated FSEC-4) came close to, but did not meet, the Go/No-Go milestone of 0.1 S/cm at 50% relative humidity at 120 °C. In-plane conductivity of membranes provided by the funded teams was measured and reported to the teams and DOE. Late in the third year of the program, DOE used this data and other factors to decide upon the teams to continue in the program. The teams that continued provided promising membranes to FSEC for development of membrane electrode assemblies (MEAs) that could be tested in an operating fuel cell. FSEC worked closely with each team to provide customized support. A logic flow chart was developed and discussed before MEA fabrication or any testing began. Of the five teams supported, by the end of the project, membranes from two of the teams were easily manufactured into MEAs and successfully characterized for performance. One of these teams exceeded performance targets, while the other requires further optimization. An additional team developed a membrane that shows great promise for significantly reducing membrane costs and increasing membrane lifetime.

  18. Communicating about obesity and weight-related topics with children with a physical disability and their families: spina bifida as an example.

    Science.gov (United States)

    McPherson, Amy C; Swift, Judy A; Peters, Michelle; Lyons, Julia; Joy Knibbe, Tara; Church, Paige; Chen, Lorry; Farrell, Renée M; Willem Gorter, Jan

    2017-04-01

    The purpose of this study was to explore the experiences of children with spina bifida (SB), their families and healthcare professionals (HCPs) when discussing weight-related topics. In-depth qualitative interviews were conducted with HCPs from Canadian outpatient SB clinics (n = 13), children aged 6-18 years with SB (n = 17) and their parents (n = 20). Data were analyzed using a phenomenological approach within an interpretative paradigm. Many HCPs were not confident talking about weight, concerned that they would damage relationships with children and families. Parents wanted routine weight surveillance, but were worried about their children's self-esteem if their weight was discussed. They wanted HCPs to acknowledge the challenges of weight management in children with a physical disability and provide specialized solutions. Children wanted a positively framed and tailored approach to weight discussions, although this had generally not been their experience. Stakeholders describe therapeutic relationships that are currently disconnected around the issue of weight and obesity. However, children, parents and HCPs all believed that discussing this topic was critical. Positively framed, strengths-based and tailored approaches to weight-related discussions are warranted. Implications for Rehabilitation Rates of overweight and obesity in children and youth with physical disabilities are substantially higher than their typically developing peers. Healthcare professionals, children with physical disabilities and families often find weight-related discussions challenging and disconnected. Weight-related discussions should be tailored to the child and family's circumstances and priorities. Positively framed and strengths-based approaches to weight-related discussions are warranted.

  19. Percolation, SLE and related topics

    CERN Document Server

    Kreimer, Dirk; Renormalization and universality in mathematical physics

    2007-01-01

    This book covers a wide range of phenomena in the natural sciences dominated by notions of universality and renormalization. The contributions in this volume are equally broad in their approach to these phenomena, offering the mathematical as well as the perspective of the applied sciences. They explore renormalization theory in quantum field theory and statistical physics, and its connections to modern mathematics as well as physics on scales from the microscopic to the macroscopic.

  20. Eulerian Graphs and Related Topics

    CERN Document Server

    Fleischner, Herbert

    1990-01-01

    The two volumes comprising Part 1 of this work embrace the theme of Eulerian trails and covering walks. They should appeal both to researchers and students, as they contain enough material for an undergraduate or graduate graph theory course which emphasizes Eulerian graphs, and thus can be read by any mathematician not yet familiar with graph theory. But they are also of interest to researchers in graph theory because they contain many recent results, some of which are only partial solutions to more general problems. A number of conjectures have been included as well. Various problems (such a

  1. Topical immunomodulators in dermatology

    Directory of Open Access Journals (Sweden)

    Khandpur Sujay

    2004-04-01

    Full Text Available Topical immunomodulators are agents that regulate the local immune response of the skin. They are now emerging as the therapy of choice for several immune-mediated dermatoses such as atopic dermatitis, contact allergic dermatitis, alopecia areata, psoriasis, vitiligo, connective tissue disorders such as morphea and lupus erythematosus, disorders of keratinization and several benign and malignant skin tumours, because of their comparable efficacy, ease of application and greater safety than their systemic counterparts. They can be used on a domiciliary basis for longer periods without aggressive monitoring. In this article, we have discussed the mechanism of action, common indications and side-effects of the commonly used topical immunomodulators, excluding topical steroids. Moreover, newer agents, which are still in the experimental stages, have also been described. A MEDLINE search was undertaken using the key words "topical immunomodulators, dermatology" and related articles were also searched. In addition, a manual search for many Indian articles, which are not indexed, was also carried out. Wherever possible, the full article was reviewed. If the full article could not be traced, the abstract was used.

  2. The impact of older person's frailty on the care-related quality of life of their informal caregiver over time: results from the TOPICS-MDS project.

    Science.gov (United States)

    Oldenkamp, Marloes; Hagedoorn, Mariët; Wittek, Rafael; Stolk, Ronald; Smidt, Nynke

    2017-10-01

    To examine the impact of changes in an older person's frailty on the care-related quality of life of their informal caregiver. Five research projects in the TOPICS-MDS database with data of both older person and informal caregiver at baseline and after 12 months follow-up were selected. Frailty was measured in five health domains (functional limitations, psychological well-being, social functioning, health-related quality of life, self-rated health). Care-related quality of life was measured with the Care-Related Quality of Life instrument (CarerQoL-7D), containing two positive (fulfilment, perceived support) and five negative dimensions (relational problems, mental health problems, physical health problems, financial problems, problems combining informal care with daily activities). 660 older person/caregiver couples were included. Older persons were on average 79 (SD 6.9) years of age, and 61% was female. Caregivers were on average 65 (SD 12.6) years of age, and 68% was female. Results of the multivariable linear and logistic regression analyses showed that an increase in older person's frailty over time was related to a lower total care-related quality of life of the caregiver, and to more mental and physical health problems, and problems with combining informal care with daily activities at follow-up. A change in the older person's psychological well-being was most important for the caregiver's care-related quality of life, compared to the other health domains. Health professionals observing decreasing psychological well-being of an older person and increasing hours of informal care provision should be aware of the considerable problems this may bring to their informal caregiver, and should tailor interventions to support informal caregivers according to their specific needs and problems.

  3. Buckling Test Results from the 8-Foot-Diameter Orthogrid-Stiffened Cylinder Test Article TA01. [Test Dates: 19-21 November 2008

    Science.gov (United States)

    Hilburger, Mark W.; Waters, W. Allen, Jr.; Haynie, Waddy T.

    2015-01-01

    Results from the testing of cylinder test article SBKF-P2-CYLTA01 (referred to herein as TA01) are presented. The testing was conducted at the Marshall Space Flight Center (MSFC), November 19?21, 2008, in support of the Shell Buckling Knockdown Factor (SBKF) Project.i The test was used to verify the performance of a newly constructed buckling test facility at MSFC and to verify the test article design and analysis approach used by the SBKF project researchers. TA01 is an 8-foot-diameter (96-inches), 78.0-inch long, aluminum-lithium (Al-Li), orthogrid-stiffened cylindrical shell similar to those used in current state-of-the-art launch vehicle structures and was designed to exhibit global buckling when subjected to compression loads. Five different load sequences were applied to TA01 during testing and included four sub-critical load sequences, i.e., loading conditions that did not cause buckling or material failure, and one final load sequence to buckling and collapse. The sub-critical load sequences consisted of either uniform axial compression loading or combined axial compression and bending and the final load sequence subjected TA01 to uniform axial compression. Traditional displacement transducers and strain gages were used to monitor the test article response at nearly 300 locations and an advanced digital image correlation system was used to obtain low-speed and high-speed full-field displacement measurements of the outer surface of the test article. Overall, the test facility and test article performed as designed. In particular, the test facility successfully applied all desired load combinations to the test article and was able to test safely into the postbuckling range of loading, and the test article failed by global buckling. In addition, the test results correlated well with initial pretest predictions.

  4. Eosinophilic Esophagitis: MedlinePlus Health Topic

    Science.gov (United States)

    ... Esophagitis (EoE) (American Academy of Allergy, Asthma, and Immunology) Also in Spanish Latest News Eosinophilic Esophagitis May ... Pediatric and Adolescent Patients (American College of Gastroenterology) Topic Image Related Health Topics Eosinophilic Disorders Esophagus Disorders ...

  5. Female Infertility: MedlinePlus Health Topic

    Science.gov (United States)

    ... Prolactin blood test (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Female Infertility updates ... Serum progesterone Show More Show Less Related Health Topics Assisted Reproductive Technology Infertility Male Infertility National Institutes ...

  6. Mobility Aids: MedlinePlus Health Topic

    Science.gov (United States)

    ... Mobility Problems (AGS Foundation for Health in Aging) Topic Image MedlinePlus Email Updates Get Mobility Aids updates ... standing and walking Using a cane Related Health Topics Assistive Devices Other Languages Find health information in ...

  7. Genetic Testing: MedlinePlus Health Topic

    Science.gov (United States)

    ... Your Family's Health (National Institutes of Health) - PDF Topic Image MedlinePlus Email Updates Get Genetic Testing updates ... testing and your cancer risk Karyotyping Related Health Topics Birth Defects Genetic Counseling Genetic Disorders Newborn Screening ...

  8. Folic Acid: MedlinePlus Health Topic

    Science.gov (United States)

    ... acid in diet (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Folic Acid updates ... acid - test Folic acid in diet Related Health Topics Vitamins National Institutes of Health The primary NIH ...

  9. Pneumococcal Infections: MedlinePlus Health Topic

    Science.gov (United States)

    ... Prevention, Immunization Action Coalition) - PDF Also in Spanish Topic Image MedlinePlus Email Updates Get Pneumococcal Infections updates ... ray Meningitis - pneumococcal Sputum gram stain Related Health Topics Meningitis Pneumonia Sepsis Sinusitis Streptococcal Infections National Institutes ...

  10. Chiropractic: MedlinePlus Health Topic

    Science.gov (United States)

    ... for back pain (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Chiropractic updates by ... ENCYCLOPEDIA Chiropractic care for back pain Related Health Topics Back Pain Complementary and Integrative Medicine National Institutes ...

  11. Wilms' Tumor: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Wilms tumor (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Wilms Tumor updates ... ENCYCLOPEDIA After chemotherapy - discharge Wilms tumor Related Health Topics Kidney Cancer National Institutes of Health The primary ...

  12. Child Safety: MedlinePlus Health Topic

    Science.gov (United States)

    ... injuries in children (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Child Safety updates ... safety Preventing head injuries in children Related Health Topics Infant and Newborn Care Internet Safety Motor Vehicle ...

  13. Diets: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Mediterranean diet (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diets updates by ... foods Diet-busting foods Mediterranean diet Related Health Topics Child Nutrition DASH Eating Plan Diabetic Diet Nutrition ...

  14. Colonoscopy: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Virtual colonoscopy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Colonoscopy updates by ... Colonoscopy Colonoscopy discharge Sigmoidoscopy Virtual colonoscopy Related Health Topics Colonic Diseases Colonic Polyps Colorectal Cancer National Institutes ...

  15. Pneumocystis Infections: MedlinePlus Health Topic

    Science.gov (United States)

    ... Pneumocystis jiroveci pneumonia (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Pneumocystis Infections updates ... GO MEDICAL ENCYCLOPEDIA Pneumocystis jiroveci pneumonia Related Health Topics HIV/AIDS HIV/AIDS and Infections Pneumonia National ...

  16. Collapsed Lung: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Pneumothorax - infants (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Collapsed Lung updates ... Lung surgery Pneumothorax - slideshow Pneumothorax - infants Related Health Topics Chest Injuries and Disorders Lung Diseases Pleural Disorders ...

  17. Male Infertility: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Testicular biopsy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Male Infertility updates ... analysis Sperm release pathway Testicular biopsy Related Health Topics Assisted Reproductive Technology Female Infertility Infertility National Institutes ...

  18. Prediabetes:MedlinePlus Health Topic

    Science.gov (United States)

    ... in Spanish Prediabetes (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Prediabetes updates by ... Glucose tolerance test - non-pregnant Prediabetes Related Health Topics A1C Diabetes Diabetes in Children and Teens Diabetes ...

  19. Healthy Aging: MedlinePlus Health Topic

    Science.gov (United States)

    ... Aging National Institute on Aging Also in Spanish Topic Image MedlinePlus Email Updates Get Healthy Aging updates ... 65 Health screening - women - over 65 Related Health Topics Exercise for Seniors Nutrition for Seniors Seniors' Health ...

  20. Psoriatic Arthritis: MedlinePlus Health Topic

    Science.gov (United States)

    ... Handouts Psoriatic arthritis (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Psoriatic Arthritis updates ... this? GO MEDICAL ENCYCLOPEDIA Psoriatic arthritis Related Health Topics Arthritis Psoriasis National Institutes of Health The primary ...

  1. Hip Replacement: MedlinePlus Health Topic

    Science.gov (United States)

    ... invasive hip replacement (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hip Replacement updates ... replacement - precautions Minimally invasive hip replacement Related Health Topics Hip Injuries and Disorders National Institutes of Health ...

  2. Diabetes: MedlinePlus Health Topic

    Science.gov (United States)

    ... High blood sugar (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diabetes updates by ... ketones test Show More Show Less Related Health Topics A1C Blood Sugar Diabetes and Pregnancy Diabetes Complications ...

  3. Platelet Disorders: MedlinePlus Health Topic

    Science.gov (United States)

    ... Thromobocytopenia - drug-induced (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Platelet Disorders updates ... Willebrand disease Show More Show Less Related Health Topics Bleeding Disorders Blood Clots Blood Count Tests Blood ...

  4. Cardiac Rehabilitation: MedlinePlus Health Topic

    Science.gov (United States)

    ... in Spanish Electrocardiogram (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cardiac Rehabilitation updates ... How to take your pulse Pulse Related Health Topics Heart Attack Heart Diseases How to Prevent Heart ...

  5. Dialysis: MedlinePlus Health Topic

    Science.gov (United States)

    ... access for hemodialysis (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Dialysis updates by ... for hemodialysis Show More Show Less Related Health Topics Creatinine Kidney Cysts Kidney Failure Peritoneal Disorders National ...

  6. Eye Wear: MedlinePlus Health Topic

    Science.gov (United States)

    ... When You Exercise (National Institute on Aging) - PDF Topic Image MedlinePlus Email Updates Get Eye Wear updates by email What's this? GO Related Health Topics Refractive Errors National Institutes of Health The primary ...

  7. Cardiac Arrest: MedlinePlus Health Topic

    Science.gov (United States)

    ... Handouts Cardiac arrest (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cardiac Arrest updates ... this? GO MEDICAL ENCYCLOPEDIA Cardiac arrest Related Health Topics Arrhythmia CPR Pacemakers and Implantable Defibrillators National Institutes ...

  8. Kawasaki Disease: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Kawasaki disease (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Kawasaki Disease updates ... GO MEDICAL ENCYCLOPEDIA Electrocardiogram Kawasaki disease Related Health Topics Vasculitis National Institutes of Health The primary NIH ...

  9. Diabetic Diet: MedlinePlus Health Topic

    Science.gov (United States)

    ... Sweeteners - sugar substitutes (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diabetic Diet updates ... you have diabetes Sweeteners - sugar substitutes Related Health Topics Blood Sugar Diabetes Diabetes in Children and Teens ...

  10. Infection Control: MedlinePlus Health Topic

    Science.gov (United States)

    ... Staph infections - hospital (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Infection Control updates ... infections when visiting Staph infections - hospital Related Health Topics Hepatitis HIV/AIDS MRSA National Institutes of Health ...

  11. Menopause: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish What is Menopause? (National Institute on Aging) Topic Image MedlinePlus Email Updates Get Menopause updates by ... test Menopause Types of hormone therapy Related Health Topics Hormone Replacement Therapy Menstruation Premature Ovarian Failure National ...

  12. Vaginitis: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Vulvovaginitis - overview (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Vaginitis updates by ... Vaginitis test - wet mount Vulvovaginitis - overview Related Health Topics Trichomoniasis Vaginal Diseases Yeast Infections Other Languages Find ...

  13. Hearing Aids: MedlinePlus Health Topic

    Science.gov (United States)

    ... for hearing loss (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hearing Aids updates ... MEDICAL ENCYCLOPEDIA Devices for hearing loss Related Health Topics Cochlear Implants Hearing Disorders and Deafness National Institutes ...

  14. Kidney Tests: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Total protein (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Kidney Tests updates ... hour volume Show More Show Less Related Health Topics Kidney Cancer Kidney Diseases National Institutes of Health ...

  15. Ischemic Stroke: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Thrombolytic therapy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Ischemic Stroke updates ... cardiogenic embolism Stroke - slideshow Thrombolytic therapy Related Health Topics Hemorrhagic Stroke Stroke Stroke Rehabilitation National Institutes of ...

  16. Pulmonary Rehabilitation: MedlinePlus Health Topic

    Science.gov (United States)

    ... Handouts Postural drainage (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Pulmonary Rehabilitation updates ... this? GO MEDICAL ENCYCLOPEDIA Postural drainage Related Health Topics Lung Diseases National Institutes of Health The primary ...

  17. Topical report review status

    International Nuclear Information System (INIS)

    1997-08-01

    This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review schedules, of all topical reports currently accepted for review by the NRC. This report will be published annually. Each sponsoring organization with one or more topical reports accepted for review copies

  18. Topics in CP violation

    International Nuclear Information System (INIS)

    Quinn, H.R.

    1993-02-01

    Given the varied backgrounds of the members of this audience this talk will be a grab bag of topics related to the general theme of CP Violation. I do not have time to dwell in detail on any of them. First, for the astronomers and astrophysicists among you, I want to begin by reviewing the experimental status of evidence for CP violation in particle processes. There is only one system where this has been observed, and that is in the decays of neutral K mesons

  19. Topics in CP violation

    Science.gov (United States)

    Quinn, H. R.

    1993-02-01

    Given the varied backgrounds of the members of this audience this talk will be a grab bag of topics related to the general theme of CP Violation. I do not have time to dwell in detail on any of them. First, for the astronomers and astrophysicists among you, I want to begin by reviewing the experimental status of evidence for CP violation in particle processes. There is only one system where this has been observed, and that is in the decays of neutral K mesons.

  20. PREFACE: International Symposium on (e,2e), Double Photoionization and Related Topics & 15th International Symposium on Polarization and Correlation in Electronic and Atomic Collisions

    Science.gov (United States)

    Martin, Nicholas L. S.; deHarak, Bruno A.

    2010-01-01

    From 30 July to 1 August 2009, over a hundred scientists from 18 countries attended the International Symposium on (e,2e), Double Photoionization and Related Topics and the 15th International Symposium on Polarization and Correlation in Electronic and Atomic Collisions which were held at the W T Young Library of the University of Kentucky, USA. Both conferences were satellite meetings of the XXVI International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC) held in Kalamazoo, Michigan, USA, 21-28 July 2009. These symposia covered a broad range of experimental and theoretical topics involving excitation, ionization (single and multiple), and molecular fragmentation, of a wide range of targets by photons and charged particles (polarized and unpolarized). Atomic targets ranged from hydrogen to the heavy elements and ions, while molecular targets ranged from H2 to large molecules of biological interest. On the experimental front, cold target recoil ion momentum spectroscopy (COLTRIMS), also known as the Reaction Microscope because of the complete information it gives about a wide variety of reactions, is becoming commonplace and has greatly expanded the ability of researchers to perform previously inaccessible coincidence experiments. Meanwhile, more conventional spectrometers are also advancing and have been used for increasingly sophisticated and exacting measurements. On the theoretical front great progress has been made in the description of target states, and in the scattering calculations used to describe both simple and complex reactions. The international nature of collaborations between theorists and experimentalists is exemplified by, for example, the paper by Ren et al which has a total of 13 authors of whom the experimental group of six is from Heidelberg, Germany, one theoretical group is from Australia, with the remainder of the theoreticians coming from several different institutions in the United States. A total of 52 invited talks and

  1. Evaluating topic models with stability

    CSIR Research Space (South Africa)

    De Waal, A

    2008-11-01

    Full Text Available Topic models are unsupervised techniques that extract likely topics from text corpora, by creating probabilistic word-topic and topic-document associations. Evaluation of topic models is a challenge because (a) topic models are often employed...

  2. Topical tags vs non-topical tags : Towards a bipartite classification?

    NARCIS (Netherlands)

    Basile, Valerio; Peroni, Silvio; Tamburini, Fabio; Vitali, Fabio

    2015-01-01

    In this paper we investigate whether it is possible to create a computational approach that allows us to distinguish topical tags (i.e. talking about the topic of a resource) and non-topical tags (i.e. describing aspects of a resource that are not related to its topic) in folksonomies, in a way that

  3. Evaluation of Novel Antimicrobial Peptides as Topical Anti-Infectives with Broad Spectrum Activity Against Combat-Related Bacterial and Fungal Wound Infections

    Science.gov (United States)

    2016-10-01

    Inc. Vallejo, CA 94592 REPORT DATE: October 2016 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort...2016 2. REPORT TYPE Annual 3. DATES COVERED 30 Sep 2015 - 29 Sep 2016 4. TITLE AND SUBTITLE Evaluation of Novel Antimicrobial Peptides as Topical...antibiotics and early debridement has been associated with a large reduction in burn wound infections. Current topical antibiotics include

  4. Topics in lightwave transmission systems

    CERN Document Server

    Li, Tingye

    1991-01-01

    Topics in Lightwave Transmission Systems is a second volume of a treatise on optical fiber communications that is devoted to the science, engineering, and application of information transmission via optical fibers. The first volume, published in 1985, dealt exclusively with fiber fabrication. The present volume contains topics that pertain to subsystems and systems. The book contains five chapters and begins with discussions of transmitters and receivers, which are basic to systems now operating in the field. Subsequent chapters cover topics relating to coherent systems: frequency and phase m

  5. Topic Model for Graph Mining.

    Science.gov (United States)

    Xuan, Junyu; Lu, Jie; Zhang, Guangquan; Luo, Xiangfeng

    2015-12-01

    Graph mining has been a popular research area because of its numerous application scenarios. Many unstructured and structured data can be represented as graphs, such as, documents, chemical molecular structures, and images. However, an issue in relation to current research on graphs is that they cannot adequately discover the topics hidden in graph-structured data which can be beneficial for both the unsupervised learning and supervised learning of the graphs. Although topic models have proved to be very successful in discovering latent topics, the standard topic models cannot be directly applied to graph-structured data due to the "bag-of-word" assumption. In this paper, an innovative graph topic model (GTM) is proposed to address this issue, which uses Bernoulli distributions to model the edges between nodes in a graph. It can, therefore, make the edges in a graph contribute to latent topic discovery and further improve the accuracy of the supervised and unsupervised learning of graphs. The experimental results on two different types of graph datasets show that the proposed GTM outperforms the latent Dirichlet allocation on classification by using the unveiled topics of these two models to represent graphs.

  6. Women's Health Topics

    Science.gov (United States)

    ... Information by Audience For Women Women's Health Topics Women's Health Topics Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print National Women's Health Week May 13 - 19, 2018 Join us ...

  7. Safety and efficacy of topical azithromycin ophthalmic solution 1.0% in the treatment of contact lens-related dry eye.

    Science.gov (United States)

    Nichols, Jason J; Bickle, Katherine M; Zink, Richard C; Schiewe, Michael D; Haque, Reza M; Nichols, Kelly K

    2012-03-01

    The purpose of this pilot study was to evaluate the safety and efficacy of azithromycin ophthalmic solution 1% in patients with contact lens-related dry eye (CLDE). This was a 4-week, single-center, open-label clinical trial in patients diagnosed with CLDE using the Contact Lens Dry Eye Questionnaire (CLDEQ). Fifty patients were enrolled in this study. The patients were randomized to 1 of 2 treatment groups: azithromycin ophthalmic solution administered bid on days 1 and 2 and on days 3 to 29±1 or Visine for Contacts rewetting drops administered qid on days 1 to 29±1. The patient diaries were used daily to collect data on comfortable and total contact lens wear time and ocular dryness throughout the treatment period. Tear osmolarity, fluorescein corneal staining, and visual acuity were also assessed during clinic visits. Fifty patients were enrolled, and 44 completed the study. One patient discontinued in the azithromycin group, and five patients discontinued in the rewetting drops group because of adverse events. A statistically significant increase in mean comfortable contact lens wear time from baseline was observed for the subjects treated with azithromycin ophthalmic solution as compared with the subjects treated with rewetting drops at week 4 (P=0.004; primary endpoint), in addition to weeks 2 and 3. The improvement in the mean comfortable wear time for the patients in the azithromycin treatment group exceeded 2 hrs throughout the treatment period (weeks 1-4). No significant differences were observed between the groups for total wear time, low contrast visual acuity, or tear osmolarity. Subject-rated ocular dryness (PM time assessments) was significantly improved from baseline in the subjects treated with azithromycin ophthalmic solution as compared with those treated with rewetting drops at weeks 2 and 3 endpoints (P=0.015 for each week). Additionally, a statistical difference was observed in favor of the azithromycin treatment group at week 2 for the

  8. Topical report review status

    International Nuclear Information System (INIS)

    1982-08-01

    A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

  9. Topical report review status

    International Nuclear Information System (INIS)

    1983-01-01

    A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

  10. Identifying Topics in Microblogs Using Wikipedia.

    Directory of Open Access Journals (Sweden)

    Ahmet Yıldırım

    Full Text Available Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA, propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision and other observations from the study are discussed in detail.

  11. Identifying Topics in Microblogs Using Wikipedia.

    Science.gov (United States)

    Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

    2016-01-01

    Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail.

  12. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    by Adam et al. In the paper by V Man'ko et al the diagonal representation of the density operator (usually called P-function of Glauber-Sudarshan) is related to the star-product quantization method and to the tomographic-probability representation of quantum states. Laskowski et al suggest an elegant geometrical criterion for the separability, which is based on the local correlation measurements readily available in the laboratory. Mizrahi describes a method to derive the Pauli-Schrödinger equation starting from a simple model of a qubit carried by a massive particle. By analyzing unavoidable quantum losses as they appear in neutron phase-echo and spin rotation experiments, Rauch concludes that basic quantum irreversibility exists in neutron interferometry. Rauch also shows how entanglement effects in a single particle system demonstrate quantum contextuality, and then argues that a quantum system carries much more information than is usually extracted. Kupczynski advocates various statistical tests which could be used to search for a fine structure in experimental data in order to answer the question: is quantum theory predictably complete? For an ion confined within a Paul trap, Mihalcea constructs an invariant operator based on the Lews and Riesenfeld approach and determines the spectrum of the quasienergy operator. Popov et al construct pair-coherent states of the Barut-Girardello kind for two noninteracting subsystems of pseudoharmonic oscillators and examine their statistical properties in different regions of parameters. The property of entanglement, considered to be the most intriguing property of composite quantum systems, has been an important research subject in recent years. It is considered to be a possible resource for quantum computation and communication. Therefore, a substantial number of papers in this topical issue is devoted to entanglement. Leon et al write that two-photon emission from two atoms initially excited in a common electromagnetic

  13. Topics in millimeter wave technology

    CERN Document Server

    Button, Kenneth

    1988-01-01

    Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

  14. Topics in broken supersymmetry

    International Nuclear Information System (INIS)

    Lee, I.H.

    1984-01-01

    Studies on two topics in the framework of broken supersymmetry are presented. Chapter I is a brief introduction in which the motivation and the background of this work are discussed. In Chapter II, the author studies the decay K + → π + γγ in models with spontaneous supersymmetry breaking and find that it is generally suppressed relative to the decay K + → π + anti nu nu of the conventional model, except possibly for a class of models where the scalar quark masses are generated by radiative corrections from a much larger supersymmetry breaking scale. For a small range of scalar quark and photino mass parameters, the cascade decay process K + → π + π 0 → π + γγ will become dominant over the anti nu nu mode. The author also comments on the possibility of probing the neutrino mass through the K + → π + π 0 → π + anti nu nu cascade decay. Chapter III is concerned with the implications of explicit lepton number violating soft operators in a general low energy effective theory with softly broken supersymmetry

  15. Diclofenac Topical (osteoarthritis pain)

    Science.gov (United States)

    ... gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the lining ... Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a ...

  16. Diclofenac Topical (actinic keratosis)

    Science.gov (United States)

    ... topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by ... The way diclofenac gel works to treat actinic keratosis is not known.Diclofenac is also available as ...

  17. Topics in Nuclear Astrophysics

    International Nuclear Information System (INIS)

    Chung, K.C.

    1982-01-01

    Some topics in nuclear astrophysics are discussed, e.g.: highly evolved stellar cores, stellar evolution (through the temperature analysis of stellar surface), nucleosynthesis and finally the solar neutrino problem. (L.C.) [pt

  18. Topical Drugs for Pain Relief

    Directory of Open Access Journals (Sweden)

    Anjali Srinivasan

    2015-03-01

    Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

  19. Recent topics in nonlinear PDE

    International Nuclear Information System (INIS)

    Mimura, Masayasu; Nishida, Takaaki

    1984-01-01

    The meeting on the subject of nonlinear partial differential equations was held at Hiroshima University in February, 1983. Leading and active mathematicians were invited to talk on their current research interests in nonlinear pdes occuring in the areas of fluid dynamics, free boundary problems, population dynamics and mathematical physics. This volume contains the theory of nonlinear pdes and the related topics which have been recently developed in Japan. (Auth.)

  20. Topics in clinical oncology. 15

    International Nuclear Information System (INIS)

    Cepcek, P.

    1987-12-01

    The monograph comprising primarily papers on topical subjects of oncology and cancer research, contains also a selection of papers presented at the 2. Congress of the Czechoslovak Society of Nuclear Medicine and Radiation Hygiene. Seven papers were selected on behalf of their subject related to clinical oncology. All of them were iputted in INIS; five of them deal with the scintiscanning of the skeleton of cancer patients, one with radioimmunodetection of tumors, and one with radionuclide lymphography. (A.K.)

  1. Topical botulinum toxin.

    Science.gov (United States)

    Collins, Ashley; Nasir, Adnan

    2010-03-01

    Nanotechnology is a rapidly growing discipline that capitalizes on the unique properties of matter engineered on the nanoscale. Vehicles incorporating nanotechnology have led to great strides in drug delivery, allowing for increased active ingredient stability, bioavailability, and site-specific targeting. Botulinum toxin has historically been used for the correction of neurological and neuromuscular disorders, such as torticollis, blepharospasm, and strabismus. Recent dermatological indications have been for the management of axillary hyperhydrosis and facial rhytides. Traditional methods of botulinum toxin delivery have been needle-based. These have been associated with increased pain and cost. Newer methods of botulinum toxin formulation have yielded topical preparations that are bioactive in small pilot clinical studies. While there are some risks associated with topical delivery, the refinement and standardization of delivery systems and techniques for the topical administration of botulinum toxin using nanotechnology is anticipated in the near future.

  2. Health Topic XML File Description

    Science.gov (United States)

    ... this page: https://medlineplus.gov/xmldescription.html Health Topic XML File Description: MedlinePlus To use the sharing ... information categories assigned. Example of a Full Health Topic Record A record for a MedlinePlus health topic ...

  3. Topics in quantum theory

    International Nuclear Information System (INIS)

    Yuille, A.L.

    1980-11-01

    Topics in the Yang-Mills theories of strong interactions and the quantum theories of gravity are examined, using the path integral approach, including; Yang-Mills instantons in curved spacetimes, Israel-Wilson metrics, Kaehler spacetimes, instantons and anti-instantons. (U.K.)

  4. Salicylic Acid Topical

    Science.gov (United States)

    ... the package label for more information.Apply a small amount of the salicylic acid product to one or two small areas you want to treat for 3 days ... know that children and teenagers who have chicken pox or the flu should not use topical salicylic ...

  5. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature i...

  6. Selected topics in magnetism

    CERN Document Server

    Gupta, L C

    1993-01-01

    Part of the ""Frontiers in Solid State Sciences"" series, this volume presents essays on such topics as spin fluctuations in Heisenberg magnets, quenching of spin fluctuations by high magnetic fields, and kondo effect and heavy fermions in rare earths amongst others.

  7. Differential Topic Models.

    Science.gov (United States)

    Chen, Changyou; Buntine, Wray; Ding, Nan; Xie, Lexing; Du, Lan

    2015-02-01

    In applications we may want to compare different document collections: they could have shared content but also different and unique aspects in particular collections. This task has been called comparative text mining or cross-collection modeling. We present a differential topic model for this application that models both topic differences and similarities. For this we use hierarchical Bayesian nonparametric models. Moreover, we found it was important to properly model power-law phenomena in topic-word distributions and thus we used the full Pitman-Yor process rather than just a Dirichlet process. Furthermore, we propose the transformed Pitman-Yor process (TPYP) to incorporate prior knowledge such as vocabulary variations in different collections into the model. To deal with the non-conjugate issue between model prior and likelihood in the TPYP, we thus propose an efficient sampling algorithm using a data augmentation technique based on the multinomial theorem. Experimental results show the model discovers interesting aspects of different collections. We also show the proposed MCMC based algorithm achieves a dramatically reduced test perplexity compared to some existing topic models. Finally, we show our model outperforms the state-of-the-art for document classification/ideology prediction on a number of text collections.

  8. Topical antifungal agents: an update.

    Science.gov (United States)

    Diehl, K B

    1996-10-01

    So many topical antifungal agents have been introduced that it has become very difficult to select the proper agent for a given infection. Nonspecific agents have been available for many years, and they are still effective in many situations. These agents include Whitfield's ointment, Castellani paint, gentian violet, potassium permanganate, undecylenic acid and selenium sulfide. Specific antifungal agents include, among others, the polyenes (nystatin, amphotericin B), the imidazoles (metronidazole, clotrimazole) and the allylamines (terbinafine, naftifine). Although the choice of an antifungal agent should be based on an accurate diagnosis, many clinicians believe that topical miconazole is a relatively effective agent for the treatment of most mycotic infections. Terbinafine and other newer drugs have primary fungicidal effects. Compared with older antifungal agents, these newer drugs can be used in lower concentrations and shorter therapeutic courses. Studies are needed to evaluate the clinical efficacies and cost advantages of both newer and traditional agents.

  9. Corneal Neurotoxicity Due to Topical Benzalkonium Chloride

    OpenAIRE

    Sarkar, Joy; Chaudhary, Shweta; Namavari, Abed; Ozturk, Okan; Chang, Jin-Hong; Yco, Lisette; Sonawane, Snehal; Khanolkar, Vishakha; Hallak, Joelle; Jain, Sandeep

    2012-01-01

    Topical application of benzalkonium chloride (BAK) to the eye causes dose-related corneal neurotoxicity. Corneal inflammation and reduction in aqueous tear production accompany neurotoxicity. Cessation of BAK treatment leads to recovery of corneal nerve density.

  10. Gastrointestinal Bleeding: MedlinePlus Health Topic

    Science.gov (United States)

    ... are many possible causes of GI bleeding, including hemorrhoids , peptic ulcers , tears or inflammation in the esophagus, ... blood Show More Show Less Related Health Topics Hemorrhoids Peptic Ulcer National Institutes of Health The primary ...

  11. Birth Weight: MedlinePlus Health Topic

    Science.gov (United States)

    ... growth restriction Large for gestational age (LGA) Neonatal weight gain and nutrition Small for gestational age (SGA) Related Health Topics Fetal Health and Development Premature Babies Uncommon Infant and Newborn Problems National Institutes of Health The primary NIH ...

  12. Topics and topic prominence in two sign languages

    NARCIS (Netherlands)

    Kimmelman, V.

    2015-01-01

    In this paper we describe topic marking in Russian Sign Language (RSL) and Sign Language of the Netherlands (NGT) and discuss whether these languages should be considered topic prominent. The formal markers of topics in RSL are sentence-initial position, a prosodic break following the topic, and

  13. Digital Social Network Mining for Topic Discovery

    Science.gov (United States)

    Moradianzadeh, Pooya; Mohi, Maryam; Sadighi Moshkenani, Mohsen

    Networked computers are expanding more and more around the world, and digital social networks becoming of great importance for many people's work and leisure. This paper mainly focused on discovering the topic of exchanging information in digital social network. In brief, our method is to use a hierarchical dictionary of related topics and words that mapped to a graph. Then, with comparing the extracted keywords from the context of social network with graph nodes, probability of relation between context and desired topics will be computed. This model can be used in many applications such as advertising, viral marketing and high-risk group detection.

  14. Topical reports on Louisiana salt domes

    International Nuclear Information System (INIS)

    1983-09-01

    The Institute for Environmental Studies at Louisiana State University conducted research into the potential use of Louisiana salt domes for disposal of nuclear waste material. Topical reports generated in 1981 and 1982 related to Vacherie and Rayburn's domes are compiled and presented, which address palynological studies, tiltmeter monitoring, precise releveling, saline springs, and surface hydrology. The latter two are basically a compilation of references related to these topics. Individual reports are abstracted

  15. Topics in numerical relativity : the periodic standing-wave approximation, the stability of constraints in free evolution, and the spin of dynamical black holes

    Science.gov (United States)

    Owen, Robert

    This thesis concerns numerical relativity, the attempt to study Einstein's theory of gravitation using numerical discretization. The goal of the field, the study of gravitational dynamics in cases where symmetry reduction or perturbation theory are not possible, finally seems to be coming to fruition, at least for the archetypal problem of the inspiral and coalescence of binary black hole systems. This thesis presents three episodes that each bear some relationship to this story.Chapters 2 and 3 present previously published work in collaboration with Richard Price and others on the so-called periodic standing-wave (PSW) approximation for binary inspiral. The approximation is to balance outgoing radiation with incoming radiation, stabilizing the orbit and making the problem stationary in a rotating frame. Chapters 2 and 3 apply the method to the problem of co-orbiting charges coupled to a nonlinear scalar field in three dimensions.Chapters 4, 5, and 6 concern the stability of constraint fields in conventional numerical relativity simulations. Chapter 4 (also previously published work, in collaboration with the Caltech numerical relativity group, along with Michael Holst and Lawrence Kidder) presents a method for immediately correcting violations of constraints after they have arisen. Chapters 5 and 6 present methods to ``damp' away constraint violations dynamically in two specific contexts. Chapter 5 (previously published work in collaboration with the Caltech numerical relativity group and Lawrence Kidder) presents a first-order linearly degenerate symmetric hyperbolic representation of Einstein's equations in generalized harmonic gauge. A representation is presented that stabilizes all constraints, including those that appear when the system is written in first-order form. Chapter 6 presents a generalization of the Kidder-Scheel-Teukolsky evolution systems that provides much-improved stability. This is investigated with numerical simulations of a single black hole

  16. Low-flow, low-permeability measurements in largely impermeable rocks. Proceedings of the NEA/AIEA workshop, Paris, 19-21 Mar 1979

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    Geological formations considered as potential candidates for the siting of radioactive waste repositories must contain no or little circulating ground water since, over the long term, ground water could transport particular radionuclides over long distances and even back to the biosphere. It is therefore essential that every candidate disposal formation be carefully evaluated in relation to its potential for transmitting fluids. Since suitable formations are necessarily characterized by negligible fluid flows, the above requirement implies some capability of measuring extremely low permeabilities in situ. The types of rocks that have been frequently considered as potential host materials for radioactive waste are rock salt, argillaceous sediments and crystalline rocks. Some countries with geologic disposal programmes are conducting or planning field experiments of various kinds. They are all confronted with the problem of how to measure very low permeabilities in situ. The OECD Nuclear Energy Agency in cooperation with the International Atomic Energy Agency organized this meeting. These proceedings constitute a record of the papers presented and the discussions held during the workshop.

  17. Topics in industrial mathematics

    International Nuclear Information System (INIS)

    Vatsya, S.R.

    1992-01-01

    Mathematical methods are widely used to solve practical problems arising in modern industry. This article outlines some of the topics relevant to AECL programmes. This covers the applications of transmission and neutron transport tomography to determine density distributions in rocks and two phase flow situations. Another example covered is the use of variational methods to solve the problems of aerosol migration and control theory. (author). 7 refs

  18. Sexual Problems in Men: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Retrograde ejaculation (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Sexual Problems in ... Premature ejaculation Reifenstein syndrome Retrograde ejaculation Related Health Topics Erectile Dysfunction Penis Disorders Prostate Diseases Testicular Disorders ...

  19. Baby Health Checkup: MedlinePlus Health Topic

    Science.gov (United States)

    ... Know (Centers for Disease Control and Prevention) - PDF Topic Image MedlinePlus Email Updates Get Baby Health Checkup ... GO MEDICAL ENCYCLOPEDIA Well-child visits Related Health Topics Childhood Immunization Common Infant and Newborn Problems Infant ...

  20. Cancer--Living with Cancer: MedlinePlus Health Topic

    Science.gov (United States)

    ... during cancer treatment (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cancer--Living with ... care plan Show More Show Less Related Health Topics Cancer Cancer Chemotherapy Palliative Care National Institutes of ...

  1. How to Prevent Heart Disease: MedlinePlus Health Topic

    Science.gov (United States)

    ... and your heart (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get How to Prevent ... your heart Stress and your heart Related Health Topics Blood Thinners Cholesterol Heart Diseases Heart Health Tests ...

  2. Tetanus, Diphtheria, and Pertussis Vaccines: MedlinePlus Health Topic

    Science.gov (United States)

    ... Know (Centers for Disease Control and Prevention) - PDF Topic Image MedlinePlus Email Updates Get Tetanus, Diphtheria, and ... updates by email What's this? GO Related Health Topics Childhood Immunization Diphtheria Immunization Tetanus Whooping Cough National ...

  3. Laser Eye Surgery: MedlinePlus Health Topic

    Science.gov (United States)

    ... corneal surgery - discharge (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Laser Eye Surgery ... surgery - what to ask your doctor Related Health Topics Refractive Errors National Institutes of Health The primary ...

  4. Child Mental Health: MedlinePlus Health Topic

    Science.gov (United States)

    ... events and children (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Child Mental Health ... in childhood Traumatic events and children Related Health Topics Bullying Child Behavior Disorders Mental Disorders Mental Health ...

  5. Bone Marrow Transplantation: MedlinePlus Health Topic

    Science.gov (United States)

    ... marrow transplant - discharge (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Bone Marrow Transplantation ... transplant - slideshow Graft-versus-host disease Related Health Topics Bone Marrow Diseases Stem Cells National Institutes of ...

  6. Nutrition for Seniors: MedlinePlus Health Topic

    Science.gov (United States)

    ... America) National Institute on Aging Also in Spanish Topic Image MedlinePlus Email Updates Get Nutrition for Seniors updates by email What's this? GO Related Health Topics Nutrition Seniors' Health National Institutes of Health The ...

  7. Blood Count Tests: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish WBC count (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Blood Count Tests ... WBC count Show More Show Less Related Health Topics Bleeding Disorders Blood Laboratory Tests National Institutes of ...

  8. Hormone Replacement Therapy: MedlinePlus Health Topic

    Science.gov (United States)

    ... of hormone therapy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hormone Replacement Therapy ... Estrogen overdose Types of hormone therapy Related Health Topics Menopause National Institutes of Health The primary NIH ...

  9. Topic Visualization and Survival Analysis

    OpenAIRE

    Wang, Ping Jr

    2017-01-01

    Latent semantic structure in a text collection is called a topic. In this thesis, we aim to visualize topics in the scientific literature and detect active or inactive research areas based on their lifetime. Topics were extracted from over 1 million abstracts from the arXiv.org database using Latent Dirichlet Allocation (LDA). Hellinger distance measures similarity between two topics. Topics are determined to be relevant if their pairwise distances are smaller than the threshold of Hellinger ...

  10. Topical cyclosporine for atopic keratoconjunctivitis.

    Science.gov (United States)

    González-López, Julio J; López-Alcalde, Jesús; Morcillo Laiz, Rafael; Fernández Buenaga, Roberto; Rebolleda Fernández, Gema

    2012-09-12

    Ophthalmologica Europaea from 2005 to July 2011. We included randomised controlled trials only. Two review authors independently extracted data. Due to the small number of studies and the diversity of outcome measures, interventions and participants, we presented results narratively. We found three RCTs with a total of 58 participants that were eligible for inclusion. There was significant variability between the trials in interventions, methodology and outcome measures and therefore we did not perform meta-analysis.One study reported on the use of 2% CsA in maize oil and two on the use of a commercial emulsion of 0.05% CsA. Of these three studies, one showed a beneficial effect of topical CsA in controlling signs and symptoms of AKC, one in controlling signs of AKC and one did not show evidence of an improvement. Only two studies analysed the effect of topical CsA in reducing topical steroid use; one showed a significant reduction in topical steroid use with CsA, but the other did not show evidence of this improvement. No serious adverse events were reported in the trials. This systematic review highlights the relative scarcity of controlled clinical trials assessing the efficacy of topical CsA therapy in AKC and suggests that evidence on the efficacy and safety of topical CsA treatment in patients with CsA remains limited. However, the data suggest that topical CsA may provide clinical and symptomatic relief in AKC and may help to reduce topical steroid use in patients with steroid-dependent or steroid-resistant AKC. No serious adverse events were reported. Reported adverse events in patients treated with topical CsA include intense stinging and eyelid skin maceration. One patient in the placebo group developed a severe allergic response to maize antigens. However, the total number of patients in the trials was too small to assess the safety of this treatment.Additional well-designed and powered RCTs of topical CsA in AKC are needed. Ideal study designs should include adequate

  11. Validation of the Care-Related Quality of Life Instrument in different study settings: findings from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS).

    Science.gov (United States)

    Lutomski, J E; van Exel, N J A; Kempen, G I J M; Moll van Charante, E P; den Elzen, W P J; Jansen, A P D; Krabbe, P F M; Steunenberg, B; Steyerberg, E W; Olde Rikkert, M G M; Melis, R J F

    2015-05-01

    Validity is a contextual aspect of a scale which may differ across sample populations and study protocols. The objective of our study was to validate the Care-Related Quality of Life Instrument (CarerQol) across two different study design features, sampling framework (general population vs. different care settings) and survey mode (interview vs. written questionnaire). Data were extracted from The Older Persons and Informal Caregivers Minimum DataSet (TOPICS-MDS, www.topics-mds.eu ), a pooled public-access data set with information on >3,000 informal caregivers throughout the Netherlands. Meta-correlations and linear mixed models between the CarerQol's seven dimensions (CarerQol-7D) and caregiver's level of happiness (CarerQol-VAS) and self-rated burden (SRB) were performed. The CarerQol-7D dimensions were correlated to the CarerQol-VAS and SRB in the pooled data set and the subgroups. The strength of correlations between CarerQol-7D dimensions and SRB was weaker among caregivers who were interviewed versus those who completed a written questionnaire. The directionality of associations between the CarerQol-VAS, SRB and the CarerQol-7D dimensions in the multivariate model supported the construct validity of the CarerQol in the pooled population. Significant interaction terms were observed in several dimensions of the CarerQol-7D across sampling frame and survey mode, suggesting meaningful differences in reporting levels. Although good scientific practice emphasises the importance of re-evaluating instrument properties in individual research studies, our findings support the validity and applicability of the CarerQol instrument in a variety of settings. Due to minor differential reporting, pooling CarerQol data collected using mixed administration modes should be interpreted with caution; for TOPICS-MDS, meta-analytic techniques may be warranted.

  12. Topics in atomic collision theory

    CERN Document Server

    Geltman, Sydney; Brueckner, Keith A

    1969-01-01

    Topics in Atomic Collision Theory originated in a course of graduate lectures given at the University of Colorado and at University College in London. It is recommended for students in physics and related fields who are interested in the application of quantum scattering theory to low-energy atomic collision phenomena. No attention is given to the electromagnetic, nuclear, or elementary particle domains. The book is organized into three parts: static field scattering, electron-atom collisions, and atom-atom collisions. These are in the order of increasing physical complexity and hence necessar

  13. Incorporating Topic Assignment Constraint and Topic Correlation Limitation into Clinical Goal Discovering for Clinical Pathway Mining

    Directory of Open Access Journals (Sweden)

    Xiao Xu

    2017-01-01

    Full Text Available Clinical pathways are widely used around the world for providing quality medical treatment and controlling healthcare cost. However, the expert-designed clinical pathways can hardly deal with the variances among hospitals and patients. It calls for more dynamic and adaptive process, which is derived from various clinical data. Topic-based clinical pathway mining is an effective approach to discover a concise process model. Through this approach, the latent topics found by latent Dirichlet allocation (LDA represent the clinical goals. And process mining methods are used to extract the temporal relations between these topics. However, the topic quality is usually not desirable due to the low performance of the LDA in clinical data. In this paper, we incorporate topic assignment constraint and topic correlation limitation into the LDA to enhance the ability of discovering high-quality topics. Two real-world datasets are used to evaluate the proposed method. The results show that the topics discovered by our method are with higher coherence, informativeness, and coverage than the original LDA. These quality topics are suitable to represent the clinical goals. Also, we illustrate that our method is effective in generating a comprehensive topic-based clinical pathway model.

  14. Topics in field theory

    CERN Document Server

    Karpilovsky, G

    1989-01-01

    This monograph gives a systematic account of certain important topics pertaining to field theory, including the central ideas, basic results and fundamental methods.Avoiding excessive technical detail, the book is intended for the student who has completed the equivalent of a standard first-year graduate algebra course. Thus it is assumed that the reader is familiar with basic ring-theoretic and group-theoretic concepts. A chapter on algebraic preliminaries is included, as well as a fairly large bibliography of works which are either directly relevant to the text or offer supplementary material of interest.

  15. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...... food-web systems, nephron pressure and flow regulation, pulsatile secretion of hormones, thermostatically controlled radiator systems, post-stall maneuvering of aircrafts, transfer electron devices for microwave generation, economic long waves, human decision making behavior, and pattern formation...... in chemical reaction-diffusion systems....

  16. Topics in Operator Theory

    CERN Document Server

    Ball, Joseph A; Helton, JWilliam; Rodman, Leiba; Spitkovsky, Iiya

    2010-01-01

    This is the first volume of a collection of original and review articles on recent advances and new directions in a multifaceted and interconnected area of mathematics and its applications. It encompasses many topics in theoretical developments in operator theory and its diverse applications in applied mathematics, physics, engineering, and other disciplines. The purpose is to bring in one volume many important original results of cutting edge research as well as authoritative review of recent achievements, challenges, and future directions in the area of operator theory and its applications.

  17. Topics in the Journal of Counseling Psychology, 1963-2015.

    Science.gov (United States)

    Oh, JungSu; Stewart, Alan E; Phelps, Rosemary E

    2017-11-01

    Historical trends in a scientific field should be apparent in the changing content of journal articles over time. Using a topic modeling approach, a statistical method for quantifying the thematic content of text, 70 topics were extracted from the abstracts of 3,603 articles published in the Journal of Counseling Psychology from 1963 to 2015. After examining interpretability of 70 topics derived from the model, 64 meaningful topics and their trends were named. In addition, the authors also classified some of the related topics into 4 categories-counseling process and outcome, multiculturalism, research methodology, and vocational psychology. Counseling process and outcome related topics have decreased recently, while topics relating to multiculturalism and diversity have shown increasing trends. The authors also discussed trends that were observed and tried to account for the changing frequencies of some important research topics within these categories. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  18. 3. Ganil session, 19 - 21 November 1979

    International Nuclear Information System (INIS)

    1979-11-01

    This report on the GANIL meetings held at CAEN the 19th, 20th and 21st of November 1979 treats first of all the opening presentation on the state of advancement of the project and the most recent principal characteristics of the beams. The texts of the sixteen adjoining papers cover an important stage in the evolution between the discussions of the 1977 meetings and the beam that we hope will be available at the end of 1982 [fr

  19. Topics on continua

    CERN Document Server

    Macias, Sergio

    2005-01-01

    Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

  20. Selected topics in e+e- physics

    International Nuclear Information System (INIS)

    Sau Lan Wu

    1981-01-01

    Selected topics of recent experimental results from the high-energy electron-positron storage rings are presented. The topics include some of the tau and charm physics from SPEAR, the upsilon physics from DORIS and CESR, and the γγ physics and quark and gluon physics from the PLUTO and TASSO Collaborations at PETRA. Related data from the JADE and MARK J Collaborations at PETRA are discussed in separated papers at this school. (orig.)

  1. Changing the Topic. Topic Position in Ancient Greek Word Order

    NARCIS (Netherlands)

    Allan, R.J.

    2014-01-01

    Ancient Greek, topics can be expressed as intra-clausal constituents but they can also precede or follow the main clause as extra-clausal constituents. Together, these various topic expressions constitute a coherent system of complementary pragmatic functions. For a comprehensive account of topic

  2. Infrared problems in QCD and related topics

    International Nuclear Information System (INIS)

    Doria, R.M.

    1981-08-01

    This thesis is based in six works. The first is presented in the Introduction in order to justify the philosophical part of the above title and to develop a concept of Reality. In Chapter 1 the presence of Infrared Divergence in QCD is discovered. It is studied in the reaction q + q → #betta#* + q + q + soft gluons, where q is the quark, #betta#* is a virtual photon. The quarks are taken each to be colour (and spin) averaged. This gives a cancellation of the leading IR divergences. The uncancelled IR divergences change the Born cross section and dimensional IR regularisation with d = 4 + eta is used. The original work had errors which produced a cancellation in such a way that did not alter the final answer. At high energies this result is proportional to (1-#betta#) ln (1-#betta#). This means that at #betta# → 1 this IR divergence effect is expected to disappear. In Chapter two, the same reaction is studied but with a gluon instead of a quark. Collinear divergence also appears. Chapter 3 is about the solution of one-loop integrals using hypergeometric functions. The solutions obtained are exact. Chapter 4 criticizes the way to predict the nature of the divergence through the Power Counting Method (NPC). (author)

  3. FM Quieting Curves and Related Topics

    Science.gov (United States)

    1977-08-01

    Electronics Engineering Group (EEO) is organized as an independent group reorting, directly to -the Comwiander, Air ’Force Conmmunica-r tions Service (WOC...NUMBER N/A 7. AklTHO -() 6. CONTRACT OR GRANT NUMBER(#) /, .C...or.e M./ Kizer/ , ,/A 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT...in vestigial sideband modulation) and are separated from the carrier frequency by a frequency difference equal to the frequency of the baseband

  4. Cycles in weighted graphs and related topics

    NARCIS (Netherlands)

    Zhang, Shenggui

    2002-01-01

    This thesis contains results on paths andcycles in graphs andon a more or less relatedtopic, the vulnerability of graphs. In the first part of the thesis, Chapters 2 through 5, we concentrate on paths andcycles in weightedgraphs. A number of sufficient conditions are presentedfor graphs to contain

  5. Radiation research and related topics in Japan

    International Nuclear Information System (INIS)

    Okamura, S.

    1974-01-01

    The polymerization and degradation reactions has been studied by the research group of Kyoto University. Different kinds of polymerization-reactions are performed at low temperature. Low temperature has induced the possibility for avoiding of side reactions and the easiness for changing reacttion phase, from gas to solid through liquid. (M.S.)

  6. The malliavin calculus and related topics

    CERN Document Server

    Nualart, David

    1995-01-01

    The Malliavin calculus (or stochastic calculus of variations) is an infinite-dimensional differential calculus on the Wiener space Originally, it was developed to prove a probabilistic proof to Hörmander's "sum of squares" theorem, but more recently it has found application in a variety of stochastic differential equation problems This monograph presents the main features of the Malliavin calculus and discusses in detail its connection with the anticipating stochastic calculus The author begins by developing analysis on the Wiener space, and then uses this to analyze the regularity of probability laws and to prove Hörmander's theorem Subsequent chapters apply the Malliavin calculus to anticipating stochastic differential equations and to studying the Markov property of solutions to stochastic differential equations with boundary conditions

  7. A Synopsis of Acquisition Related Topics.

    Science.gov (United States)

    1983-03-01

    practices, ov.rnmen-. regulations and the economic environment . As with any other reference manual, this thesis will need to be up.la:ed and supplemented...construction cor:tracts Ccpeland "Anti- 18 USC 874 Prohibits kickbacks Kickback" Act 40 USC 276c from employees on public works Maybank Azendment Annual...ttismsnt by enccuraging challenge c. cor.trac-’rs’ dAD reca.ion methods: If the method selaec.ed is also use=d for external finarcial reporting a-id :Ls

  8. Autism Spectrum Disorder (ASD): Related Topics

    Science.gov (United States)

    ... Facebook Tweet Share Compartir Q: Do vaccines cause autism spectrum disorder (ASD)? A: Many studies that have looked at whether there is a relationship between vaccines and autism spectrum disorder (ASD). To date, the studies continue to show ...

  9. Topics in atomic physics

    CERN Document Server

    Burkhardt, Charles E

    2006-01-01

    The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

  10. Topics in mathematical biology

    CERN Document Server

    Hadeler, Karl Peter

    2017-01-01

    This book analyzes the impact of quiescent phases on biological models. Quiescence arises, for example, when moving individuals stop moving, hunting predators take a rest, infected individuals are isolated, or cells enter the quiescent compartment of the cell cycle. In the first chapter of Topics in Mathematical Biology general principles about coupled and quiescent systems are derived, including results on shrinking periodic orbits and stabilization of oscillations via quiescence. In subsequent chapters classical biological models are presented in detail and challenged by the introduction of quiescence. These models include delay equations, demographic models, age structured models, Lotka-Volterra systems, replicator systems, genetic models, game theory, Nash equilibria, evolutionary stable strategies, ecological models, epidemiological models, random walks and reaction-diffusion models. In each case we find new and interesting results such as stability of fixed points and/or periodic orbits, excitability...

  11. Topical Acne Treatments and Pregnancy

    Science.gov (United States)

    Topical Acne Treatments In every pregnancy, a woman starts out with a 3-5% chance of having a baby ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

  12. 21 CFR 524.1193 - Ivermectin topical solution.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ivermectin topical solution. 524.1193 Section 524...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1193 Ivermectin topical solution. (a) Specifications. Each milliliter (mL) of solution contains 5 milligrams of...

  13. Satellite DNA: An Evolving Topic.

    Science.gov (United States)

    Garrido-Ramos, Manuel A

    2017-09-18

    Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution of such sequences. Today, with the advent of genomic tools, the study of satellite DNA has regained a great interest. Thus, Next-Generation Sequencing (NGS), together with high-throughput in silico analysis of the information contained in NGS reads, has revolutionized the analysis of the repetitive fraction of the eukaryotic genomes. The whole of the historical and current approaches to the topic gives us a broad view of the function and evolution of satellite DNA and its role in chromosomal evolution. Currently, we have extensive information on the molecular, chromosomal, biological, and population factors that affect the evolutionary fate of satellite DNA, knowledge that gives rise to a series of hypotheses that get on well with each other about the origin, spreading, and evolution of satellite DNA. In this paper, I review these hypotheses from a methodological, conceptual, and historical perspective and frame them in the context of chromosomal organization and evolution.

  14. Topics in statistical mechanics

    International Nuclear Information System (INIS)

    Elser, V.

    1984-05-01

    This thesis deals with four independent topics in statistical mechanics: (1) the dimer problem is solved exactly for a hexagonal lattice with general boundary using a known generating function from the theory of partitions. It is shown that the leading term in the entropy depends on the shape of the boundary; (2) continuum models of percolation and self-avoiding walks are introduced with the property that their series expansions are sums over linear graphs with intrinsic combinatorial weights and explicit dimension dependence; (3) a constrained SOS model is used to describe the edge of a simple cubic crystal. Low and high temperature results are derived as well as the detailed behavior near the crystal facet; (4) the microscopic model of the lambda-transition involving atomic permutation cycles is reexamined. In particular, a new derivation of the two-component field theory model of the critical behavior is presented. Results for a lattice model originally proposed by Kikuchi are extended with a high temperature series expansion and Monte Carlo simulation. 30 references

  15. Topics in supersymmetric theories

    International Nuclear Information System (INIS)

    Nemeschansky, D.D.

    1984-01-01

    This thesis discusses four different topics in supersymmetric theories. In the first part models in which supersymmetry is broken by the Fayet-Iliopoulos mechanism are considered. The possibility that scalar quark and lepton masses might arise radiatively in such theories is explored. In the second part supersymmetric grand unified models with a sliding singlet are considered. The author reviews the argument that the sliding singlet does not work in models with large supersymmetry breaking. Then he considers the possibility of using a sliding singlet with low energy supersymmetry breaking. The third part of the thesis deals with the entropy problem of supersymmetric theories. Most supersymmetric models possess a decoupled particle with mass of order 100 GeV which is copiously produced in the early universe and whose decay produces huge amounts of entropy. The author shows how this problem can be avoided in theories in which the hidden sector contains several light fields. In the fourth part effective Lagrangians for supersymmetric theories are studied. The anomalous pion interaction for supersymmetric theories is written down. General properties of this term are studied both on compact and non-compact manifolds

  16. Topics in field theory

    International Nuclear Information System (INIS)

    Velasco, E.S.

    1986-01-01

    This dissertation deals with several topics of field theory. Chapter I is a brief outline of the work presented in the next chapters. In chapter II, the Gauss-Bonnet-Chern theorem for manifolds with boundary is computed using the path integral representation of the Witten index for supersymmetric quantum mechanical systems. In chapter III the action of N = 2 (Poincare) supergravity is obtained in terms of N = 1 superfields. In chapter IV, N = 2 supergravity coupled to the (abelian) vector multiplet is projected into N - 1 superspace. There, the resulting set of constraints is solved in terms of unconstrained prepotential and the action in terms of N = 1 superfields is constructed. In chapter V the set of constraints for N = 2 conformal supergravity is projected into N = 1 superspace and solved in terms of N = 1 conformal supergravity fields a d matter prepotentials. In chapter VI the role of magnetic monopoles in the phase structure of the change one fixed length abelian Higgs model ins the latticer is investigated using analytic and numerical methods. The technique of monopole suppression is used to determine the phase transition lines that are monopole driven. Finally in chapter VII, the role of the charge of the Higgs field in the abelian Higgs model in the lattice is investigated

  17. Topics in inflationary cosmology

    International Nuclear Information System (INIS)

    Kahn, R.N.

    1985-01-01

    This thesis examines several topics in the theory of inflationary cosmology. It first proves the existence of Hawking Radiation during the slow-rolling period of a new inflationary universe. It then derives and somewhat extends Bardeen's gauge invariant formalism for calculating the growth of linear gravitational perturbations in a Friedmann-Robertson-Walker cosmological background. This formalism is then applied, first to several new inflationary universe models all of which show a Zel'dovich spectrum of fluctuations, but with amplitude sigma(100 4 ) above observational limits. The general formalism is next applied to models that exhibit primordial inflation. Fluctuations in these models also exhibit a Zel'dovich spectrum here with an acceptable amplitude. Finally the thesis presents the results of new, numerical calculations. A classical, (2 + 1) dimensional computer model is developed that includes a Higgs field (which drives inflation) along with enough auxiliary fields to generate dynamically not only a thermal bath, but also the fluctuations that naturally accompany that bath. The thesis ends with a discussion of future prospects

  18. Advanced verification topics

    CERN Document Server

    Bhattacharya, Bishnupriya; Hall, Gary; Heaton, Nick; Kashai, Yaron; Khan Neyaz; Kirshenbaum, Zeev; Shneydor, Efrat

    2011-01-01

    The Accellera Universal Verification Methodology (UVM) standard is architected to scale, but verification is growing and in more than just the digital design dimension. It is growing in the SoC dimension to include low-power and mixed-signal and the system integration dimension to include multi-language support and acceleration. These items and others all contribute to the quality of the SOC so the Metric-Driven Verification (MDV) methodology is needed to unify it all into a coherent verification plan. This book is for verification engineers and managers familiar with the UVM and the benefits it brings to digital verification but who also need to tackle specialized tasks. It is also written for the SoC project manager that is tasked with building an efficient worldwide team. While the task continues to become more complex, Advanced Verification Topics describes methodologies outside of the Accellera UVM standard, but that build on it, to provide a way for SoC teams to stay productive and profitable.

  19. Bare quantifier fronting as contrastive topicalization

    Directory of Open Access Journals (Sweden)

    Ion Giurgea

    2015-11-01

    Full Text Available I argue that indefinites (in particular bare quantifiers such as ‘something’, ‘somebody’, etc. which are neither existentially presupposed nor in the restriction of a quantifier over situations, can undergo topicalization in a number of Romance languages (Catalan, Italian, Romanian, Spanish, but only if the sentence contains “verum” focus, i.e. focus on a high degree of certainty of the sentence. I analyze these indefinites as contrastive topics, using Büring’s (1999 theory (where the term ‘S-topic’ is used for what I call ‘contrastive topic’. I propose that the topic is evaluated in relation to a scalar set including generalized quantifiers such as {lP $x P(x, lP MANYx P(x, lP MOSTx P(x, lP “xP(x} or {lP $xP(x, lP P(a, lP P(b …}, and that the contrastive topic is the weakest generalized quantifier in this set. The verum focus, which is part of the “comment” that co-occurs with the “Topic”, introduces a set of alternatives including degrees of certainty of the assertion. The speaker asserts that his claim is certainly true or highly probable, contrasting it with stronger claims for which the degree of probability is unknown. This explains the observation that in downward entailing contexts, the fronted quantified DPs are headed by ‘all’ or ‘many’, whereas ‘some’, small numbers or ‘at least n’ appear in upward entailing contexts. Unlike other cases of non-specific topics, which are property topics, these are quantifier topics: the topic part is a generalized quantifier, the comment is a property of generalized quantifiers. This explains the narrow scope of the fronted quantified DP.

  20. Evaluating topic model interpretability from a primary care physician perspective.

    Science.gov (United States)

    Arnold, Corey W; Oh, Andrea; Chen, Shawn; Speier, William

    2016-02-01

    Probabilistic topic models provide an unsupervised method for analyzing unstructured text. These models discover semantically coherent combinations of words (topics) that could be integrated in a clinical automatic summarization system for primary care physicians performing chart review. However, the human interpretability of topics discovered from clinical reports is unknown. Our objective is to assess the coherence of topics and their ability to represent the contents of clinical reports from a primary care physician's point of view. Three latent Dirichlet allocation models (50 topics, 100 topics, and 150 topics) were fit to a large collection of clinical reports. Topics were manually evaluated by primary care physicians and graduate students. Wilcoxon Signed-Rank Tests for Paired Samples were used to evaluate differences between different topic models, while differences in performance between students and primary care physicians (PCPs) were tested using Mann-Whitney U tests for each of the tasks. While the 150-topic model produced the best log likelihood, participants were most accurate at identifying words that did not belong in topics learned by the 100-topic model, suggesting that 100 topics provides better relative granularity of discovered semantic themes for the data set used in this study. Models were comparable in their ability to represent the contents of documents. Primary care physicians significantly outperformed students in both tasks. This work establishes a baseline of interpretability for topic models trained with clinical reports, and provides insights on the appropriateness of using topic models for informatics applications. Our results indicate that PCPs find discovered topics more coherent and representative of clinical reports relative to students, warranting further research into their use for automatic summarization. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  1. Topics in Bethe Ansatz

    Science.gov (United States)

    Wang, Chunguang

    Integrable quantum spin chains have close connections to integrable quantum field. theories, modern condensed matter physics, string and Yang-Mills theories. Bethe. ansatz is one of the most important approaches for solving quantum integrable spin. chains. At the heart of the algebraic structure of integrable quantum spin chains is. the quantum Yang-Baxter equation and the boundary Yang-Baxter equation. This. thesis focuses on four topics in Bethe ansatz. The Bethe equations for the isotropic periodic spin-1/2 Heisenberg chain with N. sites have solutions containing ±i/2 that are singular: both the corresponding energy and the algebraic Bethe ansatz vector are divergent. Such solutions must be carefully regularized. We consider a regularization involving a parameter that can be. determined using a generalization of the Bethe equations. These generalized Bethe. equations provide a practical way of determining which singular solutions correspond. to eigenvectors of the model. The Bethe equations for the periodic XXX and XXZ spin chains admit singular. solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to bephysical, in which case they correspond to genuine eigenvalues and eigenvectors of. the Hamiltonian. We analyze the ground state of the open spin-1/2 isotropic quantum spin chain. with a non-diagonal boundary term using a recently proposed Bethe ansatz solution. As the coefficient of the non-diagonal boundary term tends to zero, the Bethe roots. split evenly into two sets: those that remain finite, and those that become infinite. We. argue that the former satisfy conventional Bethe equations, while the latter satisfy a. generalization of the Richardson-Gaudin equations. We derive an expression for the. leading correction to the boundary energy in terms of the boundary parameters. We argue that the Hamiltonians for A(2) 2n open quantum spin chains

  2. Topic Modeling of Hierarchical Corpora /

    OpenAIRE

    Kim, Do-kyum

    2014-01-01

    The sizes of modern digital libraries have grown beyond our capacity to comprehend manually. Thus we need new tools to help us in organizing and browsing large corpora of text that do not require manually examining each document. To this end, machine learning researchers have developed topic models, statistical learning algorithms for automatic comprehension of large collections of text. Topic models provide both global and local views of a corpus; they discover topics that run through the co...

  3. Adaptive and active materials: selected papers from the ASME 2012 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 12) (Stone Mountain, GA, USA, 19-21 September 2012)

    Science.gov (United States)

    Seelecke, Stefan; Erturk, Alper; Ounaies, Zoubeida; Naguib, Hani; Huber, John; Turner, Travis; Anderson, Iain; Philen, Michael; Baba Sundaresan, Vishnu

    2013-09-01

    The fifth annual meeting of the ASME/AIAA Smart Materials, Adaptive Structures and Intelligent Systems Conference (SMASIS) was held in beautiful Stone Mountain near Atlanta, GA. It is the conference's objective to provide an up-to-date overview of research trends in the entire field of smart materials systems. This was reflected in keynote speeches by Professor Eduard Arzt (Institute of New Materials and Saarland University, Saarbrücken, Germany) on 'Micro-patterned artificial 'Gecko' surfaces: a path to switchable adhesive function', by Professor Ray H Baughman (The Alan G MacDiarmid NanoTech Institute, University of Texas at Dallas) on 'The diverse and growing family of carbon nanotube and related artificial muscles', and by Professor Richard James (University of Minnesota) on 'The direct conversion of heat to electricity using multiferroic materials with phase transformations'. SMASIS 2012 was divided into eight symposia which span basic research, applied technological design and development, and industrial and governmental integrated system and application demonstrations. • SYMP 1. Development and characterization of multifunctional materials. • SYMP 2. Mechanics and behavior of active materials. • SYMP 3. Modeling, simulation and control of adaptive systems. • SYMP 4. Integrated system design and implementation. • SYMP 5. Structural health monitoring/NDE. • SYMP 6. Bio-inspired materials and systems. • SYMP 7. Energy harvesting. • SYMP 8. Structural and materials logic. This year we were particularly excited to introduce a new symposium on energy harvesting, which has quickly matured from a special track in previous years to an independent symposium for the first time. The subject cuts across fields by studying different materials, ranging from piezoelectrics to electroactive polymers, as well as by emphasizing different energy sources from wind to waves and ambient vibrations. Modeling, experimental studies, and technology applications all

  4. Weight Control: MedlinePlus Health Topic

    Science.gov (United States)

    ... loss medications Show More Show Less Related Health Topics Body Weight Diets Eating Disorders Exercise and Physical Fitness Nutrition Obesity Weight Loss Surgery National Institutes of Health The primary NIH organization for research on Weight Control is the National Institute of ...

  5. Pain Relievers: MedlinePlus Health Topic

    Science.gov (United States)

    ... Health) ClinicalTrials.gov: Narcotics (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National ... Concentration Before Giving Acetaminophen to Infants (Food and Drug Administration) ... Related Health Topics Chronic Pain Medicines Opioid Abuse and Addiction Over-the-Counter Medicines Pain Other ...

  6. Meatotomy using topical anesthesia: A painless option

    Directory of Open Access Journals (Sweden)

    Vinod Priyadarshi

    2015-01-01

    Conclusion: Use of topical anesthesia in form of Prilox (EMLA cream for meatotomy is safe and effective method that avoids painful injections and anxiety related to it and should be considered in most of such patients as an alternative of conventional penile blocks or general anesthesia.

  7. KEY TOPICS IN SPORTS MEDICINE

    Directory of Open Access Journals (Sweden)

    Amir Ali Narvani

    2006-12-01

    Full Text Available Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1 Sports injuries, rehabilitation and injury prevention, 2 Exercise physiology, fitness testing and training, 3 Drugs in sport, 4 Exercise and health promotion, 5 Sport and exercise for special and clinical populations, 6 The psychology of performance and injury. PURPOSE The Key Topics format provides extensive, concise information in an accessible, easy-to-follow manner. AUDIENCE The book is targeted the students and specialists in sports medicine and rehabilitation, athletic training, physiotherapy and orthopaedic surgery. The editors are authorities in their respective fields and this handbook depends on their extensive experience and knowledge accumulated over the years. FEATURES The book contains the information for clinical guidance, rapid access to concise details and facts. It is composed of 99 topics which present the information in an order that is considered logical and progressive as in most texts. Chapter headings are: 1. Functional Anatomy, 2. Training Principles / Development of Strength and Power, 3. Biomechanical Principles, 4. Biomechanical Analysis, 5. Physiology of Training, 6. Monitoring of Training Progress, 7. Nutrition, 8. Hot and Cold Climates, 9. Altitude, 10. Sport and Travelling, 11. Principles of Sport Injury Diagnosis, 12. Principles of Sport and Soft Tissue Management, 13. Principles of Physical Therapy and Rehabilitation, 14. Principles of Sport Injury Prevention, 15. Sports Psychology, 16. Team Sports, 17. Psychological Aspects of Injury in Sport, 18. Injury Repair Process, 19. Basic Biomechanics of Tissue Injury, 20. Plain Film Radiography in Sport, 21. Nuclear Medicine, 22. Diagnostic Ultrasound, 23. MRI Scan, 24. Other Imaging, 5. Head Injury, 26. Eye

  8. Topics in quantum field theory

    NARCIS (Netherlands)

    Dams, C.J.F.

    2006-01-01

    In this PhD-thesis some topics in quantum field theory are considered. The first chapter gives a background to these topics. The second chapter discusses renormalization. In particular it is shown how loop calculations can be performed when using the axial gauge fixing. Fermion creation and

  9. Web directories as topical context

    NARCIS (Netherlands)

    Kaptein, R.; Kamps, J.; Aly, R.; Hauff, C.; den Hamer, I.; Hiemstra, D.; Huibers, T.; de Jong, F.

    2009-01-01

    In this paper we explore whether the Open Directory (or DMOZ) can be used to classify queries into topical categories on different levels and whether we can use this topical context to improve retrieval performance. We have set up a user study to let test persons explicitly classify queries into

  10. Resources for Topics in Architecture.

    Science.gov (United States)

    Van Noate, Judith, Comp.

    This guide for conducting library research on topics in architecture or on the work of a particular architect presents suggestions for utilizing four categories of resources: books, dictionaries and encyclopedias, indexes, and a periodicals and series list (PASL). Two topics are researched as examples: the contemporary architect Richard Meier, and…

  11. Topics in arithmetic combinatorics

    OpenAIRE

    Sanders, Tom

    2007-01-01

    E-thesis pagination differs from approved hard bound copy, Cambridge University Library classmark: PhD.30726 This thesis is chiefly concerned with a classical conjecture of Littlewood's regarding the L^1-norm of the Fourier transform, and the closely related idempotent theorem. The vast majority of the results regarding these problems are, in some sense, qualitative or at the very least infinitary and it has become increasingly apparent that a quantitative state of affairs is desirable. ...

  12. Topics on domination

    CERN Document Server

    Hedetniemi, ST

    1991-01-01

    The contributions in this volume are divided into three sections: theoretical, new models and algorithmic. The first section focuses on properties of the standard domination number &ggr;(G), the second section is concerned with new variations on the domination theme, and the third is primarily concerned with finding classes of graphs for which the domination number (and several other domination-related parameters) can be computed in polynomial time.

  13. Recent advances in topical anesthesia

    Science.gov (United States)

    2016-01-01

    Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics. Recently, new products with modified ingredients and application methods have been introduced into the market. These products may be used for mild pain during periodontal treatment, such as scaling. Dentists should be aware that topical anesthetics, although rare, might induce allergic reactions or side effects as a result of an overdose. Topical anesthetics are useful aids during dental treatment, as they reduce dental phobia, especially in children, by mitigating discomfort and pain. PMID:28879311

  14. Learning topic models by belief propagation.

    Science.gov (United States)

    Zeng, Jia; Cheung, William K; Liu, Jiming

    2013-05-01

    Latent Dirichlet allocation (LDA) is an important hierarchical Bayesian model for probabilistic topic modeling, which attracts worldwide interest and touches on many important applications in text mining, computer vision and computational biology. This paper represents the collapsed LDA as a factor graph, which enables the classic loopy belief propagation (BP) algorithm for approximate inference and parameter estimation. Although two commonly used approximate inference methods, such as variational Bayes (VB) and collapsed Gibbs sampling (GS), have gained great success in learning LDA, the proposed BP is competitive in both speed and accuracy, as validated by encouraging experimental results on four large-scale document datasets. Furthermore, the BP algorithm has the potential to become a generic scheme for learning variants of LDA-based topic models in the collapsed space. To this end, we show how to learn two typical variants of LDA-based topic models, such as author-topic models (ATM) and relational topic models (RTM), using BP based on the factor graph representations.

  15. Topics in Cosmology

    CERN Document Server

    García, José De La Luz Montero

    2008-01-01

    In a concise and simplified way, It was verified with the experimental dates of the Solar System and the 55 Cangri Extrasolar System, that the factor and the constant of planeticity, and the rotational geometric factor are nonlinear, volumetric a constant accelerations universal; it allow to enunciate the Kepler´s Fourth Law and its relation with the Fourth Principle of Thermodynamics. An understanding of the Equivalence Principle is exposed and it proves that the Universal Gravitation is an inverse quadratic function of the energetic-longitudinal constant where all the fundamental interactions converge and universal rotation of the motion of matter.

  16. [Topics of neuromyelitis optica].

    Science.gov (United States)

    Miyamoto, Katsuichi

    2014-01-01

    Neuromyelitis optica (NMO) has been revealed the difference in the pathology of multiple sclerosis since the anti-aquaporin 4 (AQP4) antibody associated with NMO has been found. The clinical epidemiological study has been reviewed, NMO-related patient number in Japan is estimated to be about 4400 people. The antibody-positive patients against myelin-oligodendrocyte glycoprotein (MOG) are present in anti-AQP4 antibody-negative NMO patients. These patients have a characteristic with high frequency of optic neuritis and good response to therapy. In addition, by research in recent years, a new treatment such as anti-IL-6 therapy or anti-complement therapy has been attempted to NMO.

  17. Topics in hyperplane arrangements

    CERN Document Server

    Aguiar, Marcelo

    2017-01-01

    This monograph studies the interplay between various algebraic, geometric and combinatorial aspects of real hyperplane arrangements. It provides a careful, organized and unified treatment of several recent developments in the field, and brings forth many new ideas and results. It has two parts, each divided into eight chapters, and five appendices with background material. Part I gives a detailed discussion on faces, flats, chambers, cones, gallery intervals, lunes and other geometric notions associated with arrangements. The Tits monoid plays a central role. Another important object is the category of lunes which generalizes the classical associative operad. Also discussed are the descent and lune identities, distance functions on chambers, and the combinatorics of the braid arrangement and related examples. Part II studies the structure and representation theory of the Tits algebra of an arrangement. It gives a detailed analysis of idempotents and Peirce decompositions, and connects them to the classical th...

  18. Topics in inflationary cosmologies

    International Nuclear Information System (INIS)

    Mahajan, S.

    1986-04-01

    Several aspects of inflationary cosmologies are discussed. An introduction to the standard hot big bang cosmological model is reviewed, and some of the problems associated with it are presented. A short review of the proposals for solving the cosmological conundrums of the big bang model is presented. Old and the new inflationary scenarios are discussed and shown to be unacceptable. Some alternative scenarios especially those using supersymmetry are reviewed briefly. A study is given of inflationary models where the same set of fields that breaks supersymmetry is also responsible for inflation. In these models, the scale of supersymmetry breaking is related to the slope of the potential near the origin and can thus be kept low. It is found that a supersymmetry breaking scale of the order of the weak breaking scale. The cosmology obtained from the simplest of such models is discussed in detail and it is shown that there are no particular problems except a low reheating temperature and a violation of the thermal constraint. A possible solution to the thermal constraint problem is given by introducing a second field, and the role played by this second field in the scenario is discussed. An alternative mechanism for the generation of baryon number within the framework of supergravity inflationary models is studied using the gravitational couplings of the heavy fields with the hidden sector (the sector which breaks supersymmetry). This mechanism is applied to two specific models - one with and one without supersymmetry breaking. The baryon to entropy ratio is found to be dependent on parameters which are model dependent. Finally, the effect of direct coupling between the two sectors on results is related, 88 refs., 6 figs

  19. Mental Mechanisms for Topics Identification

    Directory of Open Access Journals (Sweden)

    Louis Massey

    2014-01-01

    Full Text Available Topics identification (TI is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM. We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly.

  20. Topics in string theory

    Science.gov (United States)

    Jejjala, Vishnumohan

    2002-01-01

    This Thesis explores aspects of superstring theory on orbifold spaces and applies some of the intuition gleaned from the study of the non-commutative geometry of space-time to understanding the fractional quantum Hall effect. The moduli space of vacua of marginal and relevant deformations of N = 4 super-Yang-Mills gauge theory in four dimensions is interpreted in terms of non-commutative geometry. A formalism for thinking about the algebraic geometry of the moduli space is developed. Within this framework, the representation theory of the algebras studied provides a natural exposition of D-brane fractionation. The non-commutative moduli space of deformations preserving N = 1 supersymmetry is examined in detail through various examples. In string theory, by the AdS/CFT correspondence, deformations of the N = 4 field theory are dual to the near-horizon geometries of D-branes on orbifolds of AdS5 x S 5. The physics of D-branes on the dual AdS backgrounds is explored. Quivers encapsulate the matter content of supersymmetric field theories on the worldvolumes of D-branes at orbifold singularities. New techniques for constructing quivers are presented here. When N is a normal subgroup of a finite group G, the quiver corresponding to fixed points of the orbifold M/G is computed from a G/N action on the quiver corresponding to M/G . These techniques prove useful for constructing non-Abelian quivers and for examining discrete torsion orbifolds. Quivers obtained through our constructions contain interesting low-energy phenomenology. The matter content on a brane at an isolated singularity of the Delta27 orbifold embeds the Standard Model. The symmetries of the quiver require exactly three generations of fields in the particle spectrum. Lepton masses are suppressed relative to quark masses because lepton Yukawa couplings do not appear in the superpotential. Lepton masses are generated through the Kahler potential and are related to the supersymmetry breaking scale. The model

  1. Topical steroid-damaged skin

    Directory of Open Access Journals (Sweden)

    Anil Abraham

    2014-01-01

    Full Text Available Topical steroids, commonly used for a wide range of skin disorders, are associated with side effects both systemic and cutaneous. This article aims at bringing awareness among practitioners, about the cutaneous side effects of easily available, over the counter, topical steroids. This makes it important for us as dermatologists to weigh the usefulness of topical steroids versus their side effects, and to make an informed decision regarding their use in each individual based on other factors such as age, site involved and type of skin disorder.

  2. Main technical topics in 1999

    International Nuclear Information System (INIS)

    2000-01-01

    This Safety Authority annual report strives to present current organizational provisions and future trends in nuclear safety supervision in France and to describe the most outstanding occurrences during the past year. A first part presents nine documents concerning the main topics of 1999: aging of nuclear installations, the Offsite Emergency Plans (PPI), the impact of nuclear activities on man and the environment, the criticality hazards, EDF in 1999, the EPR project, the Andra in 1999, the transport incidents, the nuclear safety in eastern Europe. The second part presents the missions and actions of the Nuclear Installations Safety in the domains of the liabilities, the organization of the nuclear safety control, the regulations of the INB, the public information, the international relations, the crisis management, the radioactive materials transportation, the radioactive wastes. The equipment, the radiation protection and the exploitation of the pressurized water reactors are also treated just as the experimental reactors, the fuel cycle installations and the the nuclear installations dismantling. (A.L.B.)

  3. The Virtual Robotics Laboratory; TOPICAL

    International Nuclear Information System (INIS)

    Kress, R.L.; Love, L.J.

    1999-01-01

    The growth of the Internet has provided a unique opportunity to expand research collaborations between industry, universities, and the national laboratories. The Virtual Robotics Laboratory (VRL) is an innovative program at Oak Ridge National Laboratory (ORNL) that is focusing on the issues related to collaborative research through controlled access of laboratory equipment using the World Wide Web. The VRL will provide different levels of access to selected ORNL laboratory secondary education programs. In the past, the ORNL Robotics and Process Systems Division has developed state-of-the-art robotic systems for the Army, NASA, Department of Energy, Department of Defense, as well as many other clients. After proof of concept, many of these systems sit dormant in the laboratories. This is not out of completion of all possible research topics. but from completion of contracts and generation of new programs. In the past, a number of visiting professors have used this equipment for their own research. However, this requires that the professor, and possibly his/her students, spend extended periods at the laboratory facility. In addition, only a very exclusive group of faculty can gain access to the laboratory and hardware. The VRL is a tool that enables extended collaborative efforts without regard to geographic limitations

  4. Topics in Theoretical Physics

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Andrew [Boston Univ., MA (United States); Schmaltz, Martin [Boston Univ., MA (United States); Katz, Emmanuel [Boston Univ., MA (United States); Rebbi, Claudio [Boston Univ., MA (United States); Glashow, Sheldon [Boston Univ., MA (United States); Brower, Richard [Boston Univ., MA (United States); Pi, So-Young [Boston Univ., MA (United States)

    2016-09-30

    This award supported a broadly based research effort in theoretical particle physics, including research aimed at uncovering the laws of nature at short (subatomic) and long (cosmological) distances. These theoretical developments apply to experiments in laboratories such as CERN, the facility that operates the Large Hadron Collider outside Geneva, as well as to cosmological investigations done using telescopes and satellites. The results reported here apply to physics beyond the so-called Standard Model of particle physics; physics of high energy collisions such as those observed at the Large Hadron Collider; theoretical and mathematical tools and frameworks for describing the laws of nature at short distances; cosmology and astrophysics; and analytic and computational methods to solve theories of short distance physics. Some specific research accomplishments include + Theories of the electroweak interactions, the forces that give rise to many forms of radioactive decay; + Physics of the recently discovered Higgs boson. + Models and phenomenology of dark matter, the mysterious component of the universe, that has so far been detected only by its gravitational effects. + High energy particles in astrophysics and cosmology. + Algorithmic research and Computational methods for physics of and beyond the Standard Model. + Theory and applications of relativity and its possible limitations. + Topological effects in field theory and cosmology. + Conformally invariant systems and AdS/CFT. This award also supported significant training of students and postdoctoral fellows to lead the research effort in particle theory for the coming decades. These students and fellows worked closely with other members of the group as well as theoretical and experimental colleagues throughout the physics community. Many of the research projects funded by this grant arose in response to recently obtained experimental results in the areas of particle physics and cosmology. We describe a few of

  5. Topics in Theoretical Physics

    International Nuclear Information System (INIS)

    Cohen, Andrew; Schmaltz, Martin; Katz, Emmanuel; Rebbi, Claudio; Glashow, Sheldon; Brower, Richard; Pi, So-Young

    2016-01-01

    This award supported a broadly based research effort in theoretical particle physics, including research aimed at uncovering the laws of nature at short (subatomic) and long (cosmological) distances. These theoretical developments apply to experiments in laboratories such as CERN, the facility that operates the Large Hadron Collider outside Geneva, as well as to cosmological investigations done using telescopes and satellites. The results reported here apply to physics beyond the so-called Standard Model of particle physics; physics of high energy collisions such as those observed at the Large Hadron Collider; theoretical and mathematical tools and frameworks for describing the laws of nature at short distances; cosmology and astrophysics; and analytic and computational methods to solve theories of short distance physics. Some specific research accomplishments include + Theories of the electroweak interactions, the forces that give rise to many forms of radioactive decay; + Physics of the recently discovered Higgs boson. + Models and phenomenology of dark matter, the mysterious component of the universe, that has so far been detected only by its gravitational effects. + High energy particles in astrophysics and cosmology. + Algorithmic research and Computational methods for physics of and beyond the Standard Model. + Theory and applications of relativity and its possible limitations. + Topological effects in field theory and cosmology. + Conformally invariant systems and AdS/CFT. This award also supported significant training of students and postdoctoral fellows to lead the research effort in particle theory for the coming decades. These students and fellows worked closely with other members of the group as well as theoretical and experimental colleagues throughout the physics community. Many of the research projects funded by this grant arose in response to recently obtained experimental results in the areas of particle physics and cosmology. We describe a few of

  6. Topics in quantum gravity

    Energy Technology Data Exchange (ETDEWEB)

    Lamon, Raphael

    2010-06-29

    Quantum gravity is an attempt to unify general relativity with quantum mechanics which are the two highly successful fundamental theories of theoretical physics. The main difficulty in this unification arises from the fact that, while general relativity describes gravity as a macroscopic geometrical theory, quantum mechanics explains microscopic phenomena. As a further complication, not only do both theories describe different scales but also their philosophical ramifications and the mathematics used to describe them differ in a dramatic way. Consequently, one possible starting point of an attempt at a unification is quantum mechanics, i.e. particle physics, and try to incorporate gravitation. This pathway has been chosen by particle physicists which led to string theory. On the other hand, loop quantum gravity (LQG) chooses the other possibility, i.e. it takes the geometrical aspects of gravity seriously and quantizes geometry. The first part of this thesis deals with a generalization of loop quantum cosmology (LQC) to toroidal topologies. LQC is a quantization of homogenous solutions of Einstein's field equations using tools from LQG. First the general concepts of closed topologies is introduced with special emphasis on Thurston's theorem and its consequences. It is shown that new degrees of freedom called Teichmueller parameters come into play and their dynamics can be described by a Hamiltonian. Several numerical solutions for a toroidal universe are presented and discussed. Following the guidelines of LQG this dynamics are rewritten using the Ashtekar variables and numerical solutions are shown. However, in order to find a suitable Hilbert space a canonical transformation must be performed. On the other hand this transformation makes the quantization of geometrical quantities less tractable such that two different ways are presented. It is shown that in both cases the spectrum of such geometrical operators depends on the initial value problem

  7. Topics in quantum gravity

    International Nuclear Information System (INIS)

    Lamon, Raphael

    2010-01-01

    Quantum gravity is an attempt to unify general relativity with quantum mechanics which are the two highly successful fundamental theories of theoretical physics. The main difficulty in this unification arises from the fact that, while general relativity describes gravity as a macroscopic geometrical theory, quantum mechanics explains microscopic phenomena. As a further complication, not only do both theories describe different scales but also their philosophical ramifications and the mathematics used to describe them differ in a dramatic way. Consequently, one possible starting point of an attempt at a unification is quantum mechanics, i.e. particle physics, and try to incorporate gravitation. This pathway has been chosen by particle physicists which led to string theory. On the other hand, loop quantum gravity (LQG) chooses the other possibility, i.e. it takes the geometrical aspects of gravity seriously and quantizes geometry. The first part of this thesis deals with a generalization of loop quantum cosmology (LQC) to toroidal topologies. LQC is a quantization of homogenous solutions of Einstein's field equations using tools from LQG. First the general concepts of closed topologies is introduced with special emphasis on Thurston's theorem and its consequences. It is shown that new degrees of freedom called Teichmueller parameters come into play and their dynamics can be described by a Hamiltonian. Several numerical solutions for a toroidal universe are presented and discussed. Following the guidelines of LQG this dynamics are rewritten using the Ashtekar variables and numerical solutions are shown. However, in order to find a suitable Hilbert space a canonical transformation must be performed. On the other hand this transformation makes the quantization of geometrical quantities less tractable such that two different ways are presented. It is shown that in both cases the spectrum of such geometrical operators depends on the initial value problem. Furthermore, we

  8. Topic structure for information retrieval

    NARCIS (Netherlands)

    He, J.; Sanderson, M.; Zhai, C.; Zobel, J.; Allan, J.; Aslam, J.A.

    2009-01-01

    In my research, I propose a coherence measure, with the goal of discovering and using topic structures within and between documents, of which I explore its extensions and applications in information retrieval.

  9. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    1994-01-01

    The collection of abstracts on selected topics in nuclear structure are given. Special attention pays to collective excitations and high-spin states of nuclei, giant resonance structure, nuclear reaction mechanisms and so on

  10. Key Topics in Sports Medicine

    OpenAIRE

    2006-01-01

    Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1) Sports injuries, rehabilitation and injury prevention, 2) Exercise physiology, fitness testing and training, 3) Drugs in sport, 4) Exercise and health promotion, 5) Sport and exercise for special and clinical populations, 6) The ps...

  11. Topics of Bioengineering in Wikipedia

    Directory of Open Access Journals (Sweden)

    Vassia Atanassova

    2009-10-01

    Full Text Available The present report aims to give a snapshot of how topics from the field of bioengineering (bioinformatics, bioprocess systems, biomedical engineering, biotechnology, etc. are currently covered in the free electronic encyclopedia Wikipedia. It also offers insights and information about what Wikipedia is, how it functions, how and when to cite Wikipedian articles, if necessary. Several external wikis, devoted to topics of bioengineering, are also listed and reviewed.

  12. Topics in modern differential geometry

    CERN Document Server

    Verstraelen, Leopold

    2017-01-01

    A variety of introductory articles is provided on a wide range of topics, including variational problems on curves and surfaces with anisotropic curvature. Experts in the fields of Riemannian, Lorentzian and contact geometry present state-of-the-art reviews of their topics. The contributions are written on a graduate level and contain extended bibliographies. The ten chapters are the result of various doctoral courses which were held in 2009 and 2010 at universities in Leuven, Serbia, Romania and Spain.

  13. Topical Valproate Solution for Hair Growth

    Directory of Open Access Journals (Sweden)

    Anil Kakunje

    2018-05-01

    Full Text Available Valproate is used regularly in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis and off label in many other conditions. Alopecia or hair loss is cosmetic side effect of oral valproate administration. Hair loss with valproate is diffused, non-scarring and dose related. A large number of drugs may interfere with the hair cycle and produce hair loss. We have only a few drugs like Minoxidil, Finasteride used for hair regeneration and both have its own side effects and limitations. In contrast to oral ingestions of valproate causing hair loss, early experiments with topical Valproic acid cream showed hair regeneration. Valproic acid cream is currently unavailable in the market, alternatively, we do have valproate and divalproex solutions available in various strengths which have a potential to be used topically for hair regeneration. The side effects and cost of topical valproate solution could be much less than the available options in the market. Valproate solution topically has the potential to be used for hair growth.

  14. At-Risk and Bilingual Fifth-Grade Students' On-Task Behavior and Conceptual Understanding in Earth Science-Related Topics during Inquiry-, Technology-, and Game-Based Activities

    Science.gov (United States)

    McNeal, K.; Vasquez, Y.; Avandano, C.; Moreno, K.; Besinaiz, J.

    2007-12-01

    The Graduate K-12 (GK12) program has been developed by NSF to support the national effort to advance scientific knowledge through educational partnerships. This paper highlights research conducted during the 2006-2007 school year with the Texas A&M University GK12 project. Two elementary schools with very high numbers of at risk students - those who are poor, speak English as their second language, and have a history of failing state-mandated tests were identified to be the field site for the GK12 project. In these two, high-minority (97% and 40% African American and Hispanic) schools, 80% and 56% of the children have been identified by the state as at risk; 94% and 52% are classified as economically disadvantaged; and 46% and 2% are limited English proficient, respectively. In the past year, 30% and 73% of fifth grade students in these schools passed the science portion of the Texas Assessment of Knowledge and Skills (TAKS) test. Data collected during a three- week period where GK12 fellows taught the fifth graders Earth science-related topics is presented. During the implementation, students were engaged in technology-, inquiry-, and game-based activities. Students were divided into low-, medium-, and high-abilities in one school, and regular and bilingual groups in the other. Pre- post open-ended multiple choice tests indicated that all but the low performing students' conceptual understanding (CU) significantly (p significantly improved during the inquiry activity, and the high and bilingual students' CU significantly improved for the game activities. Classroom observation assessments showed that there was a significant (p Significant differences between student groups' CU and on-task behavior indicated that technology-based activities showed greatest differences between the low- ability learners and the other students, whereas, inquiry-based activities tended not to show such extremes. In the case of the bilingual and regular students however, technology

  15. Deep Unfolding for Topic Models.

    Science.gov (United States)

    Chien, Jen-Tzung; Lee, Chao-Hsi

    2018-02-01

    Deep unfolding provides an approach to integrate the probabilistic generative models and the deterministic neural networks. Such an approach is benefited by deep representation, easy interpretation, flexible learning and stochastic modeling. This study develops the unsupervised and supervised learning of deep unfolded topic models for document representation and classification. Conventionally, the unsupervised and supervised topic models are inferred via the variational inference algorithm where the model parameters are estimated by maximizing the lower bound of logarithm of marginal likelihood using input documents without and with class labels, respectively. The representation capability or classification accuracy is constrained by the variational lower bound and the tied model parameters across inference procedure. This paper aims to relax these constraints by directly maximizing the end performance criterion and continuously untying the parameters in learning process via deep unfolding inference (DUI). The inference procedure is treated as the layer-wise learning in a deep neural network. The end performance is iteratively improved by using the estimated topic parameters according to the exponentiated updates. Deep learning of topic models is therefore implemented through a back-propagation procedure. Experimental results show the merits of DUI with increasing number of layers compared with variational inference in unsupervised as well as supervised topic models.

  16. Grand unification and gravity - selected topics

    International Nuclear Information System (INIS)

    Zee, A.

    1981-09-01

    The material given here was presented in lectures delivered at the 4th Kyoto Summer Institute on Grand Unification and Related Topics. It consists of six sections. The sections are: the family problem, fermion mass hierarchy, maximal local symmetry, operator analysis of new physics, dynamically generated gravity, and Kaluza theory and grand unification. The last section contains a (hopefully) pedagogical introduction to Kaluza theory. For pedagogical completeness, several appendices reviewing some elementary notions of differential geometry have been added

  17. Extracting Hot spots of Topics from Time Stamped Documents

    Science.gov (United States)

    Chen, Wei; Chundi, Parvathi

    2011-01-01

    Identifying time periods with a burst of activities related to a topic has been an important problem in analyzing time-stamped documents. In this paper, we propose an approach to extract a hot spot of a given topic in a time-stamped document set. Topics can be basic, containing a simple list of keywords, or complex. Logical relationships such as and, or, and not are used to build complex topics from basic topics. A concept of presence measure of a topic based on fuzzy set theory is introduced to compute the amount of information related to the topic in the document set. Each interval in the time period of the document set is associated with a numeric value which we call the discrepancy score. A high discrepancy score indicates that the documents in the time interval are more focused on the topic than those outside of the time interval. A hot spot of a given topic is defined as a time interval with the highest discrepancy score. We first describe a naive implementation for extracting hot spots. We then construct an algorithm called EHE (Efficient Hot Spot Extraction) using several efficient strategies to improve performance. We also introduce the notion of a topic DAG to facilitate an efficient computation of presence measures of complex topics. The proposed approach is illustrated by several experiments on a subset of the TDT-Pilot Corpus and DBLP conference data set. The experiments show that the proposed EHE algorithm significantly outperforms the naive one, and the extracted hot spots of given topics are meaningful. PMID:21765568

  18. Selected Abstracts of the 19th National Congress of the Italian Society of Perinatal Medicine (Società Italiana di Medicina Perinatale, SIMP; Naples (Italy; January 19-21, 2017

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-01-01

    Full Text Available Selected Abstracts of the 19th National Congress of the Italian Society of Perinatal Medicine (Società Italiana di Medicina Perinatale, SIMP; Naples (Italy; January 19-21, 2017 Guest Editors: Irene Cetin, Mariavittoria Locci ABS 1. THE “WOMAN AND CHILD HOSPITAL” ORGANIZED ON INTENSITY OF CARE IN VERONA: AN OPPORTUNITY TO PROMOTE MATERNAL AND PERINATAL HEALTH • C. Bovo, R. Bortolus, G. Ghirlanda, P. Biban, V. Bergamini, A. Bonetti, E. Allegrini, G. PiacentiniABS 2. CIRCULATING LEVELS OF NATURAL KILLER T CELLS AND ENDOTHELIAL PROGENITOR CELLS IN PRE-ECLAMPTIC PREGNANT WOMEN • E. Piccione, F. Basile, A. Santamaria, L. Rizzo, D. Giordano, S. Loddo, R. D’AnnaABS 3. CLASSIFICATION OF THE RISK FACTORS FOR STILLBIRTH FOLLOWING THE IMPLEMENTATION OF A CLINICAL AUDIT METHOD: PRELIMINARY DATA FROM A WIDE AREA IN NORTHERN ITALY • A. Ferretti, L. Galli, A. Dall’Asta, S. Fieni, T. FruscaABS 4. CESAREAN SECTION: INDICATIONS AND INCIDENCE IN THE LAST DECADES • L. Rizzo, F. Basile, A. Santamaria, R. D’AnnaABS 5. MATERNAL NEAR MISS: A 10-YEAR SURVEILLANCE STUDY IN A TERTIARY CARE FACILITY OF NORTHERN ITALY • G. Zanconato, C. Bovo, E. Cavaliere, R. Bortolus, R. Castellani, M. FranchiABS 6. IS LENTICULOSTRIATED VASCULOPATHY AT HEAD ULTRASOUND AN UNFAVORABLE PROGNOSTIC FINDING IN PATIENTS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION? • A. De Matteis, A. Giannattasio, P. Di Costanzo, P. Milite, D. De Martino, M.R. Augurio, C. Grande, E. Capone, A. Romano, F. RaimondiABS 7. MATERNAL IMMUNOSUPPRESSION AND RISK OF SEVERE CONGENITAL CYTOMEGALOVIRUS INFECTION • A. De Matteis, A. Giannattasio, S. Cenni, L. Bucci, P. Milite, F. Raimondi, P. Di CostanzoABS 8. NEUROIMAGING STUDIES AND NEURODEVELOPMENTAL OUTCOME IN A LARGE COHORT OF INFANTS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION • C. Grande, M.R. Augurio, D. De Martino, L. Bucci, L. Capasso, P. Di Costanzo, A. Giannattasio, F. RaimondiABS 9. POSTPARTUM HEMORRHAGE RISK AFTER EXPOSURE TO SSRIs DURING

  19. Quantum mechanics II advanced topics

    CERN Document Server

    Rajasekar, S

    2015-01-01

    Quantum Mechanics II: Advanced Topics uses more than a decade of research and the authors’ own teaching experience to expound on some of the more advanced topics and current research in quantum mechanics. A follow-up to the authors introductory book Quantum Mechanics I: The Fundamentals, this book begins with a chapter on quantum field theory, and goes on to present basic principles, key features, and applications. It outlines recent quantum technologies and phenomena, and introduces growing topics of interest in quantum mechanics. The authors describe promising applications that include ghost imaging, detection of weak amplitude objects, entangled two-photon microscopy, detection of small displacements, lithography, metrology, and teleportation of optical images. They also present worked-out examples and provide numerous problems at the end of each chapter.

  20. Topical application of hemostatic paste

    Directory of Open Access Journals (Sweden)

    Mohammad Mizanur Rahman

    2017-02-01

    Full Text Available As a measure to control minor surgical bleeding, surgeons usually depend on a number of hemostatic aids. Topical use of bovine thrombin is a widely used procedure to arrest such minor bleeding. A 35 year old male sergeant of Bangladesh Air Force presented with repeated development of hematoma in his left thigh without any history of trauma or previous history of bleeding. Critical analysis of the patient’s history, routine and sophisticated hematological investigations revealed that the patient developed anti-thrombin antibody following the application of hemostatic paste in the tooth socket five years back during minor dental procedure to stop ignorable bleeding episodes. Therefore, topical use of hemostatic glue/paste or bovine thrombin should be avoided to desist minor bleeding as recombinant human thrombin is now available for topical use.

  1. Selected topics of fluid mechanics

    Science.gov (United States)

    Kindsvater, Carl E.

    1958-01-01

    the Euler, Froude, Reynolds, Weber, and Cauchy numbers are defined as essential tools for interpreting and using experimental data. The derivations of the energy and momentum equations are treated in detail. One-dimensional equations for steady nonuniform flow are developed, and the restrictions applicable to the equations are emphasized. Conditions of uniform and gradually varied flow are discussed, and the origin of the Chezy equation is examined in relation to both the energy and the momentum equations. The inadequacy of all uniform-flow equations as a means of describing gradually varied flow is explained. Thus, one of the definitive problems of river hydraulics is analyzed in the light of present knowledge. This report is the outgrowth of a series of short schools conducted during the spring and summer of 1953 for engineers of the Surface Water Branch, Water Resources Division, U. S. Geological Survey. The topics considered are essentially the same as the topics selected for inclusion in the schools. However, in order that they might serve better as a guide and outline for informal study, the arrangement of the writer's original lecture notes has been considerably altered. The purpose of the report, like the purpose of the schools which inspired it, is to build a simple but strong framework of the fundamentals of fluid mechanics. It is believed that this framework is capable of supporting a detailed analysis of most of the practical problems met by the engineers of the Geological Survey. It is hoped that the least accomplishment of this work will be to inspire the reader with the confidence and desire to read more of the recent and current technical literature of modern fluid mechanics.

  2. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Solov'ev, V.G.; Gromov, K.Ya.; Malov, L.A.; Shilov, V.M.

    1994-01-01

    The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles. heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and β-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei

  3. Selected topics in nuclear structure

    Energy Technology Data Exchange (ETDEWEB)

    Solov` ev, V G; Gromov, K Ya; Malov, L A; Shilov, V M

    1994-12-31

    The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles). heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and {beta}-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei.

  4. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  5. Selected topics in grand unification

    International Nuclear Information System (INIS)

    Seckel, D.

    1983-01-01

    This dissertation is a collection of four pieces of research dealing with grand unification. The topics are neutron oscillation, CP violation, magnetic monopole abundance and distribution in neutron stars, and a proposal for an inflationary cosmology driven by stress-energy in domain walls

  6. Topics in elementary particle physics

    International Nuclear Information System (INIS)

    Dugan, M.J.

    1985-01-01

    Topics in elementary particle physics are discussed. Models with N = 2 supersymmetry are constructed. The CP violation properties of a class of N = 1 supergravity models are analyzed. The structure of a composite Higgs model is investigated. The implications of a 17 keV neutrino are considered

  7. Resources for Topics in Nursing.

    Science.gov (United States)

    Riordan, Dale B.

    This guide is intended to help the user become familiar with a selected group of reference tools and resources which are useful in nursing education and practice. It is important for students to use the correct medical or scientific terminology, understand the scope of a topic, and then utilize the tools necessary to research subjects of interest.…

  8. Seven topics in perturbative QCD

    International Nuclear Information System (INIS)

    Buras, A.J.

    1980-09-01

    The following topics of perturbative QCD are discussed: (1) deep inelastic scattering; (2) higher order corrections to e + e - annihilation, to photon structure functions and to quarkonia decays; (3) higher order corrections to fragmentation functions and to various semi-inclusive processes; (4) higher twist contributions; (5) exclusive processes; (6) transverse momentum effects; (7) jet and photon physics

  9. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Stachura, Z.

    1984-09-01

    19. winter school in Zakopane was devoted to selected topics in nuclear structure such as: production of spin resonances, heavy ions reactions and their applications to the investigation of high spin states, octupole deformations, excited states and production of new elements etc. The experimental data are ofen compared with theoretical predictions. Report contains 28 papers. (M.F.W.)

  10. Hot Topics in Science Teaching

    Science.gov (United States)

    Ediger, Marlow

    2018-01-01

    There are vital topics in science teaching and learning which are mentioned frequently in the literature. Specialists advocate their importance in the curriculum as well as science teachers stress their saliency. Inservice education might well assist new and veteran teachers in knowledge and skills. The very best science lessons and units of…

  11. Topic Map for Authentic Travel

    OpenAIRE

    Wandsvik, Atle; Zare, Mehdi

    2007-01-01

    E-business is a new trend in Internet use. Authentic travel is an approach to travel and travel business which helps the traveler experience what is authentic in the travel destination. But how can the traveler find those small authentic spots and organize them together to compose a vacation? E-business techniques, combined withTopic Maps, can help.

  12. Two topics in quantum chromodynamics

    International Nuclear Information System (INIS)

    Bjorken, J.D.

    1989-12-01

    The two topics are (1) estimates of perturbation theory coefficients for R(e + e - → hadrons), and (2) the virtual-photon structure function, with emphasis on the analytic behavior in its squared mass. 20 refs., 4 figs., 2 tabs

  13. Topical Session on Materials Management

    International Nuclear Information System (INIS)

    2002-01-01

    At its second meeting, in Paris, 5-7 December 2001, the WPDD held two topical sessions on the D and D Safety Case and on the Management of Materials from D and D, respectively. This report documents the topical session on the management of materials. Presentations during the topical session covered key aspects of the management of materials and meant to provide an exchange of information and experience, including: Experience and lessons learnt from VLLW and non-radioactive material management in Spain and Germany with special attention to recycling (How specific solutions came about? Are there 'generic' examples for wider adoption?); Risk assessment of recycling and non-recycling: a CPD study; Waste acceptance issues within different national contexts (What constraints are there on the waste receiving body and what flexibility can the latter have? What constraints does this impose on D and D implementers? What about wastes are without current solution? What needs to be done? What about large items and 'difficult' waste in general?); Radiological characterisation of materials during decommissioning, particularly difficult situations - large volumes, large items,.. wastes, heterogeneous streams (What examples of established practice? What are the approaches or aspects that set the regulatory requirements? How can the flow rates be large but the answers acceptable? How much is needed to be known for later action, e. g., disposal, release, protection of worker, etc.); Radiological characterisation of buildings as they stand, in order to allow conventional demolition (What are strategies for optimisation of characterisation? How much needs to be known to take action later? e.g. for storage, disposal, release, cost estimation and ALARA? What needs to be done in advance and after decommissioning/dismantling?). At the end of each presentation time was allotted for discussion of the paper. Integral to the Topical Session was a facilitated plenary discussion on the topical

  14. Topics in Gravitation and Cosmology

    Science.gov (United States)

    Bahrami Taghanaki, Sina

    This thesis is focused on two topics in which relativistic gravitational fields play an important role, namely early Universe cosmology and black hole physics. The theory of cosmic inflation has emerged as the most successful theory of the very early Universe with concrete and verifiable predictions for the properties of anisotropies of the cosmic microwave background radiation and large scale structure. Coalescences of black hole binaries have recently been detected by the Laser Interferometer Gravitational Wave Observatory (LIGO), opening a new arena for observationally testing the dynamics of gravity. In part I of this thesis we explore some modifications to the standard theory of inflation. The main predictions of single field slow-roll inflation have been largely consistent with cosmological observations. However, there remain some aspects of the theory that are not presently well understood. Among these are the somewhat interrelated issues of the choice of initial state for perturbations and the potential imprints of pre-inflationary dynamics. It is well known that a key prediction of the standard theory of inflation, namely the Gaussianity of perturbations, is a consequence of choosing a natural vacuum initial state. In chapter 3, we study the generation and detectability of non-Gaussianities in inflationary scalar perturbations that originate from more general choices of initial state. After that, in chapter 4, we study a simple but predictive model of pre-inflationary dynamics in an attempt to test the robustness of inflationary predictions. We find that significant deviations from the standard predictions are unlikely to result from models in which the inflaton field decouples from the pre-inflationary degrees of freedom prior to freeze-out of the observable modes. In part II we turn to a study of an aspect of the thermodynamics of black holes, a subject which has led to important advances in our understanding of quantum gravity. For objects which

  15. Exercise for Seniors: MedlinePlus Health Topic

    Science.gov (United States)

    ... GO MEDICAL ENCYCLOPEDIA Exercise and age Related Health Topics Exercise and Physical Fitness Seniors' Health Sports Fitness National Institutes of Health The primary NIH organization for research on Exercise for Seniors is the National Institute ...

  16. Topical and working papers on uranium resources and availability

    International Nuclear Information System (INIS)

    Basic topics relative to world-wide resources and availability of uranium resources; potential for recovery of uranium from mill tailings in Canada; uranium from seawater; depleted uranium as an energy source; world uranium requirements in perspective

  17. Exercise and Physical Fitness: MedlinePlus Health Topic

    Science.gov (United States)

    ... Learn to love exercise Make time to move Outdoor fitness routine Physical activity Working with a personal trainer Yoga for health Show More Show Less Related Health Topics Benefits of Exercise Exercise for Children Exercise for Seniors ...

  18. Topics in computational linear optimization

    DEFF Research Database (Denmark)

    Hultberg, Tim Helge

    2000-01-01

    Linear optimization has been an active area of research ever since the pioneering work of G. Dantzig more than 50 years ago. This research has produced a long sequence of practical as well as theoretical improvements of the solution techniques avilable for solving linear optimization problems...... of high quality solvers and the use of algebraic modelling systems to handle the communication between the modeller and the solver. This dissertation features four topics in computational linear optimization: A) automatic reformulation of mixed 0/1 linear programs, B) direct solution of sparse unsymmetric...... systems of linear equations, C) reduction of linear programs and D) integration of algebraic modelling of linear optimization problems in C++. Each of these topics is treated in a separate paper included in this dissertation. The efficiency of solving mixed 0-1 linear programs by linear programming based...

  19. Do scientists trace hot topics?

    Science.gov (United States)

    Wei, Tian; Li, Menghui; Wu, Chensheng; Yan, Xiao-Yong; Fan, Ying; Di, Zengru; Wu, Jinshan

    2013-01-01

    Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of papers belonging to the field. This indicates that scientists generally do follow hot topics. However, there are qualitative differences among scientists from various countries, among research works regarding different number of authors, different number of affiliations and different number of references. These observations could be valuable for policy makers when deciding research funding and also for individual researchers when searching for scientific projects.

  20. Application of Topic Map on Knowledge Organization

    Directory of Open Access Journals (Sweden)

    Sou-shan Wu

    2003-06-01

    Full Text Available Knowledge management (KM has received much attention from both academics and practitioners in the past few years. Following the KM trend, many organizations have built their own knowledge repositories or data warehouses. However, information or knowledge is still scattered everywhere without being properly managed. The rapid growth of the Internet accelerates the creation of unstructured and unclassified information and causes the explosion of information overload. The effort of browsing information through general-purpose search engines turns out to be tedious and painstaking. Hence, an effective technology to solve this information retrieval problem is much needed. The purpose of this research is to explore the application of text mining technique in organizing knowledge stored in unstructured natural language text documents. Major components of text mining techniques required for topic map in particular will be presented in detail.Two sets of unstructured documents are utilized to demonstrate the usage of SOM for topic categorization. The first set of documents is a collection of speeches given by Y.C. Wang, Chairman of the Taiwan Plastics Group, and the other is the collection of all laws and regulations related to securities and future markets in Taiwan. We also try to apply text mining to these two sets of documents to generate their respective topic maps, thus revealing the differences between organizing explicit and tacit knowledge as well as the difficulties associated with tacit knowledge.[Article content in Chinese

  1. Topics in statistical and theoretical physics

    CERN Document Server

    Dobrushin, R L; Shubin, M A

    1996-01-01

    This is the second of two volumes dedicated to the scientific heritage of F. A. Berezin (1931-1980). Before his untimely death, Berezin had an important influence on physics and mathematics, discovering new ideas in mathematical physics, representation theory, analysis, geometry, and other areas of mathematics. His crowning achievements were the introduction of a new notion of deformation quantization and Grassmannian analysis ("supermathematics"). Collected here are papers by many of his colleagues and others who worked in related areas, representing a wide spectrum of topics in statistical a

  2. Tactile friction of topical formulations.

    Science.gov (United States)

    Skedung, L; Buraczewska-Norin, I; Dawood, N; Rutland, M W; Ringstad, L

    2016-02-01

    The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Topic extraction from adverbial clauses

    Directory of Open Access Journals (Sweden)

    Carlos Rubio Alcalá

    2016-06-01

    Full Text Available This paper offers new data to support findings about Topic extraction from adverbial clauses. Since such clauses are strong islands, they should not allow extraction of any kind, but we show here that if the appropriate conditions are met, Topics of the CLLD kind in Romance can move out of them. We propose that two conditions must be met for such movement to be possible: the first is that the adverbial clause must have undergone topicalisation in the first place; the second is that the adverbial clause is inherently topical from a semantic viewpoint. Contrast with other language families (Germanic, Quechua and Japanese is provided and the semantic implications of the proposal are briefly discussed. Keywords: topicalisation; Clitic Left Dislocation; syntactic islands; adverbial clauses Este artículo ofrece nuevos datos sobre la extracción de Tópicos desde oraciones subordinadas adverbiales. Dado que dichas oraciones son islas fuertes, no deberían permitir extracción de ningún tipo, pero mostramos que si se dan las condiciones apropiadas, los Tópicos del tipo CLLD en lenguas románicas pueden desplazarse fuera de ellas. Proponemos que se deben cumplir dos condiciones para que ese movimiento sea posible: la primera es que la propia subordinada adverbial se haya topicalizado en primer lugar; la segunda es que la subordinada adverbial sea inherentemente un Tópico desde el punto de vista semántico. Proporcionamos también algunos contrastes con otras familias lingüísticas (germánica, quechua y japonés y se discuten brevemente las implicaciones semánticas de la propuesta. Palabras clave: topicalización; dislocación a la izquierda con clítico; islas sintácticas; oraciones adverbiales

  4. Modern topics in electron scattering

    CERN Document Server

    Frois, Bernard

    1991-01-01

    This book summarizes the considerable progress recently achieved in the understanding of nucleon and nuclear structure by using high energy electrons as a probe. A collection of papers discusses in detail the new frontiers of this field. Experimental and theoretical articles cover topics such as the structure of the nucleon, nucleon distributions, many-body correlations, non-nucleonic degrees of freedom and few-body systems. This book is an up-to-date introduction to the research planned with continuous beam electron accelerators.

  5. Topics in deep inelastic scattering

    International Nuclear Information System (INIS)

    Wandzura, S.M.

    1977-01-01

    Several topics in deep inelastic lepton--nucleon scattering are discussed, with emphasis on the structure functions appearing in polarized experiments. The major results are: infinite set of new sum rules reducing the number of independent spin dependent structure functions (for electroproduction) from two to one; the application of the techniques of Nachtmann to extract the coefficients appearing in the Wilson operator product expansion; and radiative corrections to the Wilson coefficients of free field theory. Also discussed are the use of dimensional regularization to simplify the calculation of these radiative corrections

  6. Topics in conformal field theory

    International Nuclear Information System (INIS)

    Kiritsis, E.B.

    1988-01-01

    In this work two major topics in Conformal Field Theory are discussed. First a detailed investigation of N = 2 Superconformal theories is presented. The structure of the representations of the N = 2 superconformal algebras is investigated and the character formulae are calculated. The general structure of N = 2 superconformal theories is elucidated and the operator algebra of the minimal models is derived. The first minimal system is discussed in more detail. Second, applications of the conformal techniques are studied in the Ashkin-Teller model. The c = 1 as well as the c = 1/2 critical lines are discussed in detail

  7. Theoretical topics in particle physics

    International Nuclear Information System (INIS)

    Roberts, L.A.

    1986-01-01

    This dissertation contains three parts, each with a distinct topic. The three topics are (1) Higgs-boson decays at the superconducting supercollider, (2) radiative corrections to the decay π 0 → γe + e - and (3) generalized random paths in three and four dimensions. In part I, distributions in cos(theta)/sub lab/, rapidity, energy, and p/sub T/ for the intermediate vector bosons resulting from p + p → (H 0 → W + W - , Z 0 Z 0 ) + X and p + p → (W + W - , W + Z 0 + W - Z 0 ,Z 0 Z 0 ) + X at √s = 40 TeV are compared for Higgs-boson masses of 5m/sub w/ and 7m/sub w/. The Higgs-boson-decay signal should be visible in the energy and p/sub T/ distributions of the vector bosons. In Part II, the radiative corrections to both the decay rate for π 0 → γe + e - and the differential spectrum in the invariant mass of the Dalitz pain for experiments with limited geometrical acceptance are calculated. In Part III, the author introduces a generalized model for random paths (in arbitrary dimension) which smoothly interpolates between the standard paths (fermionic or bosonic) and the self-avoiding paths. An efficient Monte Carlo algorithm to simulate the model is presented along with some preliminary results for the average length, intersection, overlap and mean square size of paths in three and four dimensions

  8. Topics in nonlinear wave theory with applications

    International Nuclear Information System (INIS)

    Tracy, E.R.

    1984-01-01

    Selected topics in nonlinear wave theory are discussed, and applications to the study of modulational instabilities are presented. A historical survey is given of topics relating to solitons and modulational problems. A method is then presented for generating exact periodic and quasi-periodic solutions to several nonlinear wave equations, which have important physical applications. The method is then specialized for the purposes of studying the modulational instability of a plane wave solution of the nonlinear Schroedinger equation, an equation with general applicability in one-dimensional modulational problems. Some numerical results obtained in conjunction with the analytic study are presented. The analytic approach explains the recurrence phenomena seen in the numerical studies, and the numerical work of other authors. The method of solution (related to the inverse scattering method) is then analyzed within the context of Hamiltonian dynamics where it is shown that the method can be viewed as simply a pair of canonical transformations. The Abel Transformation, which appears here and in the work of other authors, is shown to be a special form of Liouville's transformation to action-angle variables. The construction of closed form solutions of these nonlinear wave equations, via the solution of Jacobi's inversion problem, is surveyed briefly

  9. Topics in Banach space theory

    CERN Document Server

    Albiac, Fernando

    2016-01-01

    This text provides the reader with the necessary technical tools and background to reach the frontiers of research without the introduction of too many extraneous concepts. Detailed and accessible proofs are included, as are a variety of exercises and problems. The two new chapters in this second edition are devoted to two topics of much current interest amongst functional analysts: Greedy approximation with respect to bases in Banach spaces and nonlinear geometry of Banach spaces. This new material is intended to present these two directions of research for their intrinsic importance within Banach space theory, and to motivate graduate students interested in learning more about them. This textbook assumes only a basic knowledge of functional analysis, giving the reader a self-contained overview of the ideas and techniques in the development of modern Banach space theory. Special emphasis is placed on the study of the classical Lebesgue spaces Lp (and their sequence space analogues) and spaces of continuous f...

  10. Synergetics introduction and advanced topics

    CERN Document Server

    Haken, Hermann

    2004-01-01

    This book is an often-requested reprint of two classic texts by H. Haken: "Synergetics. An Introduction" and "Advanced Synergetics". Synergetics, an interdisciplinary research program initiated by H. Haken in 1969, deals with the systematic and methodological approach to the rapidly growing field of complexity. Going well beyond qualitative analogies between complex systems in fields as diverse as physics, chemistry, biology, sociology and economics, Synergetics uses tools from theoretical physics and mathematics to construct an unifying framework within which quantitative descriptions of complex, self-organizing systems can be made. This may well explain the timelessness of H. Haken's original texts on this topic, which are now recognized as landmarks in the field of complex systems. They provide both the beginning graduate student and the seasoned researcher with solid knowledge of the basic concepts and mathematical tools. Moreover, they admirably convey the spirit of the pioneering work by the founder of ...

  11. Topics in b-physics

    International Nuclear Information System (INIS)

    Bjorken, J.D.

    1988-09-01

    We discuss a few issues in the burgeoning field of physics of hadrons containing the b-quark. These include: A simple parameterization of the Kobayashi-Maskawa matrix featuring a triangle in the complex plane, a review of B/sub s/ and B/sub d/ mixing with special attention given to width-mixing and the CP-violating same-sign dilepton asymmetry, a discussion of the CP-violating decay B/sub d/ → /psi/π + π/sup /minus//, and a discussion of Cp-violating rate asymmetries in the two-body decays Λ/sub b/ → pπ/sup /minus// and Λ/sub b/ → pK/sup /minus//. The concluding discussion concerns generalizations beyond these specific topics. 22 refs., 6 figs

  12. Conclusion from the fifth topic

    International Nuclear Information System (INIS)

    Gin, St.; Advocat, Th.

    1997-01-01

    The topic ''mechanics and alteration kinetics of glasses'' is a crucial point for the understanding of the long-term behaviour of nuclear glasses. Kinetic models used in simulation are based on the works made by Grambow who imputes the control of the alteration kinetics of borosilicate glasses to the desorption of the ortho-silica acid produced at the reactive interface. The ensuing kinetics law requires the existence of an equilibrium of the silica at the interface glass/gel and the existence of a linear concentration gradient dissolved in the interstitial gel solution. The role of the gel needs further studies to be well understood. The difficulty lies in the fact that the composition and the structure of the gel varies with time, space (anisotropy) and with the conditions of alteration (temperature, pH, flowrate...). (A.C.)

  13. Antibiotic Resistance: MedlinePlus Health Topic

    Science.gov (United States)

    ... GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home → Health Topics → Antibiotic Resistance URL of this page: https://medlineplus.gov/antibioticresistance. ...

  14. Topical Antibacterials and Global Challenges on Resistance ...

    African Journals Online (AJOL)

    skin infections can be easily treated with topical antibacterial medication that is available over the counter or by ... infection in minor cut or burn, eyes and ear infection [5]. .... Sensitive/dry skin ... includes both oral and topical antibiotics, but.

  15. Topic prominence in Chinese EFL learners’ interlanguage

    Directory of Open Access Journals (Sweden)

    Shaopeng Li

    2014-01-01

    Full Text Available The present study aims to investigate the general characteristics of topicprominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from a discourse perspective. Topic structures mainly appear in Chinese discourse in the form of topic chains (Wang, 2002; 2004. The research target are the topic chain, which is the main topic-prominent structure in Chinese discourse, and zero anaphora, which is the most common topic anaphora in the topic chain. Two important findings emerged from the present study. First, the characteristics of Chinese topic chains are transferrable to the interlanguage of Chinese EFL learners, thus resulting in overgeneralization of the zero anaphora. Second, the interlanguage discourse of Chinese EFL learners reflects a change of the second language acquisition process from topic-prominence to subject-prominence, thus lending support to the discourse transfer hypothesis.

  16. Human-competitive automatic topic indexing

    CERN Document Server

    Medelyan, Olena

    2009-01-01

    Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

  17. An Introduction to Topic Modeling as an Unsupervised Machine Learning Way to Organize Text Information

    Science.gov (United States)

    Snyder, Robin M.

    2015-01-01

    The field of topic modeling has become increasingly important over the past few years. Topic modeling is an unsupervised machine learning way to organize text (or image or DNA, etc.) information such that related pieces of text can be identified. This paper/session will present/discuss the current state of topic modeling, why it is important, and…

  18. An overview of topic modeling and its current applications in bioinformatics.

    Science.gov (United States)

    Liu, Lin; Tang, Lin; Dong, Wen; Yao, Shaowen; Zhou, Wei

    2016-01-01

    With the rapid accumulation of biological datasets, machine learning methods designed to automate data analysis are urgently needed. In recent years, so-called topic models that originated from the field of natural language processing have been receiving much attention in bioinformatics because of their interpretability. Our aim was to review the application and development of topic models for bioinformatics. This paper starts with the description of a topic model, with a focus on the understanding of topic modeling. A general outline is provided on how to build an application in a topic model and how to develop a topic model. Meanwhile, the literature on application of topic models to biological data was searched and analyzed in depth. According to the types of models and the analogy between the concept of document-topic-word and a biological object (as well as the tasks of a topic model), we categorized the related studies and provided an outlook on the use of topic models for the development of bioinformatics applications. Topic modeling is a useful method (in contrast to the traditional means of data reduction in bioinformatics) and enhances researchers' ability to interpret biological information. Nevertheless, due to the lack of topic models optimized for specific biological data, the studies on topic modeling in biological data still have a long and challenging road ahead. We believe that topic models are a promising method for various applications in bioinformatics research.

  19. Topical report review status: Volume 10

    International Nuclear Information System (INIS)

    1996-03-01

    This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review by the NRC. This report is published annually

  20. Topic modelling in the information warfare domain

    CSIR Research Space (South Africa)

    De Waal, A

    2013-11-01

    Full Text Available for interesting and relevant topics. The objectives of this paper is to describe topic modelling, put it in context as a useful IW technique and illustrate its use with two examples. They discuss several applications of topic modelling in the safety and security...

  1. Credibility improves topical blog post retrieval

    NARCIS (Netherlands)

    Weerkamp, W.; de Rijke, M.

    2008-01-01

    Topical blog post retrieval is the task of ranking blog posts with respect to their relevance for a given topic. To improve topical blog post retrieval we incorporate textual credibility indicators in the retrieval process. We consider two groups of indicators: post level (determined using

  2. The Prosody of Topic Transition in Interaction: Pitch Register Variations.

    Science.gov (United States)

    Riou, Marine

    2017-12-01

    In conversation, speakers can mobilize a variety of prosodic cues to signal a switch in topics. This paper uses a mixed-methods approach combining Conversation Analysis and Instrumental Prosody to investigate the prosody of topic transition in American English, and analyzes the ways in which speakers can play on register level and on register span. A cluster of three prosodic parameters was found to be predictive of transitions: a higher maximum fundamental frequency (F0), a higher median F0 (key), and an expanded register span. Relative to speakers' habitual profiles, the mobilization of such prosodic cues corresponds to a marked upgraded prosodic design. This finding is consistent with the general assumption that continuation constitutes the norm in conversation, and that departing from it, as in the case of a topic transition, requires a marked action and marked linguistic design. The disjunctive action of opening a new topic corresponds to the use of a marked prosodic cue.

  3. Topical tacrolimus for atopic dermatitis.

    Science.gov (United States)

    Cury Martins, Jade; Martins, Ciro; Aoki, Valeria; Gois, Aecio F T; Ishii, Henrique A; da Silva, Edina M K

    2015-07-01

    Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs). To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments. We searched the following databases up to 3 June 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 5, 2015), MEDLINE (from 1946), EMBASE (from 1974), LILACS (from 1982), and the Global Resource of Eczema Trials (GREAT database). We searched six trials registers and checked the bibliographies of included studies for further references to relevant trials. We contacted specialists in the field for unpublished data.A separate search for adverse effects of topical tacrolimus was undertaken in MEDLINE and EMBASE on 30 July 2013. We also scrutinised the U.S. Food and Drug Administration (FDA) websites for adverse effects information. All randomised controlled trials (RCTs) of participants with moderate to severe atopic dermatitis (both children and adults) using topical tacrolimus at any dose, course duration, and follow-up time compared with other active treatments. Two authors independently screened and examined the full text of selected studies for compliance with eligibility criteria, risk of bias, and data extraction. Our three prespecified primary outcomes were physician's assessment, participant's self-assessment of improvement, and adverse effects. Our secondary outcomes included assessment of improvement of the disease by validated or objective measures, such as

  4. Topical medication instillation techniques for glaucoma.

    Science.gov (United States)

    Xu, Li; Wang, Xuemei; Wu, Meijing

    2017-02-20

    Glaucoma is a leading cause of irreversible blindness worldwide and the second most common cause of blindness after cataracts. The primary treatment for glaucoma aims to lower intraocular pressure (IOP) with the use of topical medicines. Topical medication instillation techniques, such as eyelid closure and nasolacrimal occlusion when instilling drops, have been proposed as potential methods to increase ocular absorption and decrease systemic absorption of the drops. To investigate the effectiveness of topical medication instillation techniques compared with usual care or another method of instillation of topical medication in the management of glaucoma or ocular hypertension. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 12), MEDLINE Ovid (1946 to 8 December 2016), Embase Ovid (1947 to 8 December 2016), PubMed (1948 to 8 December 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 8 December 2016), International Pharmaceutical Abstracts Database (1970 to 8 December 2016), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) (last searched 13 May 2013), ClinicalTrials.gov (www.clinicaltrials.gov) (searched 8 December 2016) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en) (searched 8 December 2016). We did not use any date or language restrictions in the electronic searches for trials. We included randomized controlled trials which had compared any topical medication instillation technique with usual care or a different method of instillation of topical medication. Two review authors independently screened records from the searches for eligibility, assessed the risk of bias, and extracted data. We followed methods recommended by Cochrane. We identified two trials (122 eyes of 61 participants) that had evaluated a topical medication instillation technique. We

  5. Topics in particle physics phenomenology

    International Nuclear Information System (INIS)

    Pantaleone, J.T.

    1985-01-01

    This thesis consists of topics in field theory. In part A: (Chapter 1) A short review of heavy-quark physics, (Chapter 2) Spin-dependent forces in heavy-quark systems, (Chapter 3) Bound state effects in the Upsilon → γ + resonance, and in part B, The compatibility of free fractional charge and Dirac magnetic monopoles. In Chapter 2, using the results of the fourth-order quark-antiquark interactions in perturbative QCD, we show that the spin-dependent potentials in the formalism of Eichten and Feinberg and Gromes have to be generalized to include the quark mass dependence. The recently observed hyperfine and fine structure splittings in the J/psi and Upsilon systems are found to agree with the purely perturbative QCD results for the scale parameter Λ/sub MS/ = 0.30 +/- 0.06 GeV. With this value for Λ/sub MS/ we give some predictions on the T and toponium spectroscopies. In Chapter 3 we study the effect of b anti b bound state dynamics on the reaction Upsilon → γ + resonance. We argue from the results that the recently discovered sigma (8320) must have a scalar, rather than a pseudoscalar, coupling to the b quark

  6. Decision Point 1 Topical Report

    Energy Technology Data Exchange (ETDEWEB)

    Yablonsky, Al; Barsoumian, Shant; Legere, David

    2013-05-01

    This Topical Report addresses accomplishments achieved during Phase 2a of the SkyMine® Carbon Mineralization Pilot Project. The primary objectives of this project are to design, construct, and operate a system to capture CO2 from a slipstream of flue gas from a commercial coal-fired cement kiln, convert that CO2 to products having commercial value (i.e., beneficial use), show the economic viability of the CO2 capture and conversion process, and thereby advance the technology to the point of readiness for commercial scale demonstration and proliferation. The overall process is carbon negative, resulting in mineralization of CO2 that would otherwise be released into the atmosphere. The project will also substantiate market opportunities for the technology by sales of chemicals into existing markets, and identify opportunities to improve technology performance and reduce costs at the commercial scale. The project is being conducted in two phases. The primary objectives of Phase 1 were to elaborate proven SkyMine® process chemistry to commercial pilot-scale operation and complete the preliminary design for the pilot plant to be built and operated in Phase 2, complete a NEPA evaluation, and develop a comprehensive carbon life cycle analysis. The objective of the current Phase (2a) is to complete the detailed design of the pilot plant to be built in Phase 2b.

  7. Topics in Number Theory Conference

    CERN Document Server

    Andrews, George; Ono, Ken

    1999-01-01

    From July 31 through August 3,1997, the Pennsylvania State University hosted the Topics in Number Theory Conference. The conference was organized by Ken Ono and myself. By writing the preface, I am afforded the opportunity to express my gratitude to Ken for beng the inspiring and driving force behind the whole conference. Without his energy, enthusiasm and skill the entire event would never have occurred. We are extremely grateful to the sponsors of the conference: The National Sci­ ence Foundation, The Penn State Conference Center and the Penn State Depart­ ment of Mathematics. The object in this conference was to provide a variety of presentations giving a current picture of recent, significant work in number theory. There were eight plenary lectures: H. Darmon (McGill University), "Non-vanishing of L-functions and their derivatives modulo p. " A. Granville (University of Georgia), "Mean values of multiplicative functions. " C. Pomerance (University of Georgia), "Recent results in primality testing. " C. ...

  8. Topical subjects of nuclear energy

    International Nuclear Information System (INIS)

    1977-12-01

    The controversy as regards the introduction of nuclear energy to the energy supply of the Federal Republic of Germany has not subdued yet. However, the discussion has shifted from technical questions more to the field of political argumentation. In addition, questions concerning the back end cycle have come to the fore. The report at hand deals with the topical subjects of fuel reprocessing, ultimate storage of radioactive wastes, the impact of power plants in general and nuclear power plants in particular on the climate, safety and safeguard questions concerning nuclear facilities and fissionable materials, and with the properties and possibilities of plutonium. The authors tried to present technical know-how in an easy comprehensible way. Literature references enable the checking of facts and provide the possibility to deal in more detail with the matter. The seminar report is to give all those interested the opportunity to acquaint themselves with facts and know-how and to acquire knowledge on which to base a personal opinion. (orig.) [de

  9. Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch

    Directory of Open Access Journals (Sweden)

    David R Lionberger

    2010-11-01

    Full Text Available David R Lionberger1, Michael J Brennan21Southwest Orthopedic Group, Houston, TX, USA; 2Department of Medicine, Bridgeport Hospital, Bridgeport, CT, USAAbstract: The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs, diclofenac, and DETP in patients with acute soft tissue injuries was included. Relevant literature was identified on MEDLINE using the search terms topical NSAIDs, diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, strain, sprain, and contusion, and from citations in retrieved articles covering the years 1978–2008. Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5–1.9. In a limited number of comparisons, topical and oral NSAIDs provided comparable pain relief, but the use of topical agents produced lower plasma drug concentrations and fewer systemic adverse events (AEs. The physical–chemical properties of diclofenac epolamine make it well suited for topical use. In patients with acute soft tissue injuries treated with DETP, clinical data report an analgesic benefit within hours of the first application, and significant pain relief relative to placebo within 3 days. Moreover, DETP displayed tolerability comparable with placebo; the most common AEs were pruritus and other application site reactions. Review of published literature suggests that DETP is generally safe and well tolerated, clinically efficacious, and a rational treatment option for patients experiencing acute pain associated with strains, sprains, and contusions, and other localized painful conditions

  10. Advanced Materials and Process Technology for Mechanical Failure Prevention (Proceedings of the Meeting of the Mechanical Failures Prevention Group (48th) Held in Wakefield, Massachusetts on 19-21 April 1994,

    Science.gov (United States)

    1994-04-21

    stress rupture fractured specimens (a) as- ROC’ed, (b) beat treated by schedule 2. (a) (b) (c) (d) Figure 6: SEM fractographs of super-a, tensile... beat 195 - - . -i The microstructure in the weld region and at the fatigue failures was studied and related o the observed failures.Fati ue data are...inspector also can use one or two audio output channels for either mono or stereo ( binaural ) presentation of the aural information. Auralkatlon of

  11. Current topics in summability theory and applications

    CERN Document Server

    Rhoades, Billy

    2016-01-01

    This book discusses recent developments in and contemporary research on summability theory, including general summability methods, direct theorems on summability, absolute and strong summability, special methods of summability, functional analytic methods in summability, and related topics and applications. All contributing authors are eminent scientists, researchers and scholars in their respective fields, and hail from around the world. The book can be used as a textbook for graduate and senior undergraduate students, and as a valuable reference guide for researchers and practitioners in the fields of summability theory and functional analysis. Summability theory is generally used in analysis and applied mathematics. It plays an important part in the engineering sciences, and various aspects of the theory have long since been studied by researchers all over the world. .

  12. #Healthy Selfies: Exploration of Health Topics on Instagram.

    Science.gov (United States)

    Muralidhara, Sachin; Paul, Michael J

    2018-06-29

    Social media provides a complementary source of information for public health surveillance. The dominate data source for this type of monitoring is the microblogging platform Twitter, which is convenient due to the free availability of public data. Less is known about the utility of other social media platforms, despite their popularity. This work aims to characterize the health topics that are prominently discussed in the image-sharing platform Instagram, as a step toward understanding how this data might be used for public health research. The study uses a topic modeling approach to discover topics in a dataset of 96,426 Instagram posts containing hashtags related to health. We use a polylingual topic model, initially developed for datasets in different natural languages, to model different modalities of data: hashtags, caption words, and image tags automatically extracted using a computer vision tool. We identified 47 health-related topics in the data (kappa=.77), covering ten broad categories: acute illness, alternative medicine, chronic illness and pain, diet, exercise, health care & medicine, mental health, musculoskeletal health and dermatology, sleep, and substance use. The most prevalent topics were related to diet (8,293/96,426; 8.6% of posts) and exercise (7,328/96,426; 7.6% of posts). A large and diverse set of health topics are discussed in Instagram. The extracted image tags were generally too coarse and noisy to be used for identifying posts but were in some cases accurate for identifying images relevant to studying diet and substance use. Instagram shows potential as a source of public health information, though limitations in data collection and metadata availability may limit its use in comparison to platforms like Twitter. ©Sachin Muralidhara, Michael J. Paul. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 29.06.2018.

  13. Validation of the Care-Related Quality of Life Instrument in different study settings : findings from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS)

    NARCIS (Netherlands)

    Lutomski, J. E.; van Exel, N. J. A.; Kempen, G. I. J. M.; van Charante, E. P. Moll; den Elzen, W. P. J.; Jansen, A. P. D.; Krabbe, P. F. M.; Steunenberg, B.; Steyerberg, E. W.; Rikkert, M. G. M. Olde; Melis, R. J. F.

    PURPOSE: Validity is a contextual aspect of a scale which may differ across sample populations and study protocols. The objective of our study was to validate the Care-Related Quality of Life Instrument (CarerQol) across two different study design features, sampling framework (general population vs.

  14. Validation of the Care-Related Quality of Life Instrument in different study settings: findings from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS)

    NARCIS (Netherlands)

    Lutomski, J.E.; Exel, N.J. van; Kempen, G.I.; Charante, E.P. Moll van; Elzen, W.P. den; Jansen, A.P.; Krabbe, P.F.M.; Steunenberg, B.; Steyerberg, E.W.; Olde Rikkert, M.G.M.; Melis, R.J.F.

    2015-01-01

    PURPOSE: Validity is a contextual aspect of a scale which may differ across sample populations and study protocols. The objective of our study was to validate the Care-Related Quality of Life Instrument (CarerQol) across two different study design features, sampling framework (general population vs.

  15. 75 FR 26647 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

    Science.gov (United States)

    2010-05-12

    .... FDA-2010-N-0002] Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution... are treated with a topical solution of ivermectin. DATES: This rule is effective May 12, 2010. FOR... ANADA 200-340 for PRIVERMECTIN (ivermectin), a topical solution used on cattle to control infestations...

  16. Hot topic: apparent total-tract nutrient digestibilities measured commercially using 120-hour in vitro indigestible neutral detergent fiber as a marker are related to commercial dairy cattle performance.

    Science.gov (United States)

    Schalla, A; Meyer, L; Meyer, Z; Onetti, S; Schultz, A; Goeser, J

    2012-09-01

    Measuring individual feed nutrient concentration is common practice for field dairy nutritionists. However, accurately measuring nutrient digestibility and using digestion values in total digestible nutrients models is more challenging. Our objective was to determine if in vivo apparent total-tract nutrient digestibility measured with a practical approach was related to commercial milk production parameters. Total mixed ration and fecal samples were collected from high-producing cows in pens on 39 commercial dairies and analyzed at a commercial feed and forage testing laboratory for nutrient concentration and 120-h indigestible NDF (iNDF) content using the Combs-Goeser in vitro digestion technique. The 120-h iNDF was used as an internal marker to calculate in vivo apparent nutrient digestibilities. Two samples were taken from each dairy and were separated in time by at least 3 wk. Samples were targeted to be taken within 7d of Dairy Herd Improvement (DHI) herd testing. Approved DHI testers measured individual cow milk weights as well as fat and protein concentrations. Individual cow records were averaged by pen corresponding to the total mixed ration and fecal samples. Formulated diet and dry matter intake (DMI) records for each respective pen were also collected. Mixed model regression analysis with dairy specified as a random effect was used to relate explanatory variables (diet nutrient concentrations, formulated DMI, in vivo apparent nutrient digestibilities, and fecal nutrient concentrations) to milk production measures. Dry matter intake, organic matter (OM) digestibility, fecal crude protein (CP) concentration, and fecal ether extract concentration were related to milk, energy-corrected milk, and fat yields. Milk protein concentration was related to CP digestibility, and milk protein yield was related to DMI, OM digestibility, CP digestibility, and ether extract digestibility. Although many studies have related DMI and OM digestibility to milk production

  17. Teachers' Views of Moral Education Topics - Taiwan and the USA

    Science.gov (United States)

    Lin, Huey-Ya; Davidman, Patricia; Petersen, George; Thomas, R. Murray

    1998-01-01

    In a questionnaire survey, 94 teachers in Taiwan and 140 in the United States judged which topics among 20 moral issues would be appropriate subjects of study in grade six of the primary school and in the first year of the university. The issues related to religion, ethnicity, gender, health care, crime, alcohol, tobacco, gambling, guns, government corruption, birth control, caring for the elderly, and television programming. The results revealed great diversity of opinion within each group of respondents. No single topic was approved by all teachers in either group, nor was any topic rejected by all. Among the 234 teachers, no two offered precisely the same configuration of answers over the 20 topics. Nevertheless, some group trends could be identified for individual topics. For example, in both countries the great majority of respondents would teach about industrial pollution, whereas very few would approve of trying to identify the best religion. In the rationales teachers offered in support of their choices, the four reasons that figured most prominently in both countries were that a topic would contribute to the nation's welfare, would help students to make wise decisions, would be interesting for students, and would represent a peaceful way to face social problems.

  18. Analyzing research trends on drug safety using topic modeling.

    Science.gov (United States)

    Zou, Chen

    2018-04-06

    Published drug safety data has evolved in the past decade due to scientific and technological advances in the relevant research fields. Considering that a vast amount of scientific literature has been published in this area, it is not easy to identify the key information. Topic modeling has emerged as a powerful tool to extract meaningful information from a large volume of unstructured texts. Areas covered: We analyzed the titles and abstracts of 4347 articles in four journals dedicated to drug safety from 2007 to 2016. We applied Latent Dirichlet allocation (LDA) model to extract 50 main topics, and conducted trend analysis to explore the temporal popularity of these topics over years. Expert Opinion/Commentary: We found that 'benefit-risk assessment and communication', 'diabetes' and 'biologic therapy for autoimmune diseases' are the top 3 most published topics. The topics relevant to the use of electronic health records/observational data for safety surveillance are becoming increasingly popular over time. Meanwhile, there is a slight decrease in research on signal detection based on spontaneous reporting, although spontaneous reporting still plays an important role in benefit-risk assessment. The topics related to medical conditions and treatment showed highly dynamic patterns over time.

  19. Recent Advances In Topical Therapy In Dermatology

    Directory of Open Access Journals (Sweden)

    Mohan Thappa Devinder

    2003-01-01

    Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

  20. Vaccine Hesitancy in Discussion Forums: Computer-Assisted Argument Mining with Topic Models.

    Science.gov (United States)

    Skeppstedt, Maria; Kerren, Andreas; Stede, Manfred

    2018-01-01

    Arguments used when vaccination is debated on Internet discussion forums might give us valuable insights into reasons behind vaccine hesitancy. In this study, we applied automatic topic modelling on a collection of 943 discussion posts in which vaccine was debated, and six distinct discussion topics were detected by the algorithm. When manually coding the posts ranked as most typical for these six topics, a set of semantically coherent arguments were identified for each extracted topic. This indicates that topic modelling is a useful method for automatically identifying vaccine-related discussion topics and for identifying debate posts where these topics are discussed. This functionality could facilitate manual coding of salient arguments, and thereby form an important component in a system for computer-assisted coding of vaccine-related discussions.

  1. Topics in elementary particle physics

    Science.gov (United States)

    Jin, Xiang

    The author of this thesis discusses two topics in elementary particle physics: n-ary algebras and their applications to M-theory (Part I), and functional evolution and Renormalization Group flows (Part II). In part I, Lie algebra is extended to four different n-ary algebraic structure: generalized Lie algebra, Filippov algebra, Nambu algebra and Nambu-Poisson tensor; though there are still many other n-ary algebras. A natural property of Generalized Lie algebras — the Bremner identity, is studied, and proved with a totally different method from its original version. We extend Bremner identity to n-bracket cases, where n is an arbitrary odd integer. Filippov algebras do not focus on associativity, and are defined by the Fundamental identity. We add associativity to Filippov algebras, and give examples of how to construct Filippov algebras from su(2), bosonic oscillator, Virasoro algebra. We try to include fermionic charges into the ternary Virasoro-Witt algebra, but the attempt fails because fermionic charges keep generating new charges that make the algebra not closed. We also study the Bremner identity restriction on Nambu algebras and Nambu-Poisson tensors. So far, the only example 3-algebra being used in physics is the BLG model with 3-algebra A4, describing two M2-branes interactions. Its extension with Nambu algebra, BLG-NB model, is believed to describe infinite M2-branes condensation. Also, there is another propose for M2-brane interactions, the ABJM model, which is constructed by ordinary Lie algebra. We compare the symmetry properties between them, and discuss the possible approaches to include these three models into a grand unification theory. In Part II, we give an approximate solution for Schroeder's equations, based on series and conjugation methods. We use the logistic map as an example, and demonstrate that this approximate solution converges to known analytical solutions around the fixed point, around which the approximate solution is constructed

  2. Unsupervised topic discovery by anomaly detection

    OpenAIRE

    Cheng, Leon

    2013-01-01

    Approved for public release; distribution is unlimited With the vast amount of information and public comment available online, it is of increasing interest to understand what is being said and what topics are trending online. Government agencies, for example, want to know what policies concern the public without having to look through thousands of comments manually. Topic detection provides automatic identification of topics in documents based on the information content and enhances many ...

  3. Tracking topic birth and death in LDA.

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Andrew T.; Robinson, David Gerald

    2011-09-01

    Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

  4. Topic Time Series Analysis of Microblogs

    Science.gov (United States)

    2014-10-01

    may be distributed more globally. Tweets on a specific topic that cluster spatially, temporally or both might be of interest to analysts, marketers ...of $ and @, with the latter only in the case that it is the only character in the token (the @ symbol is significant in its usage by Instagram in...is generated by Instagram . Topic 80, Distance: 143.2101 Top words: 1. rawr 2. ˆ0ˆ 3. kill 4. jurassic 5. dinosaur Analysis: This topic is quite

  5. Topical Day on Site Remediation

    Energy Technology Data Exchange (ETDEWEB)

    Vandenhove, H [ed.

    1996-09-18

    Ongoing activities at the Belgian Nuclear Research Centre relating to site remediation and restoration are summarized. Special attention has been paid to the different phases of remediation including characterization, impact assessment, evaluation of remediation actions, and execution of remediation actions.

  6. Updates of Topical and Local Anesthesia Agents.

    Science.gov (United States)

    Boyce, Ricardo A; Kirpalani, Tarun; Mohan, Naveen

    2016-04-01

    As described in this article, there are many advances in topical and local anesthesia. Topical and local anesthetics have played a great role in dentistry in alleviating the fears of patients, eliminating pain, and providing pain control. Many invasive procedures would not be performed without the use and advances of topical/local anesthetics. The modern-day dentist has the responsibility of knowing the variety of products on the market and should have at least references to access before, during, and after treatment. This practice ensures proper care with topical and local anesthetics for the masses of patients entering dental offices worldwide. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.

    Science.gov (United States)

    Lionberger, David R; Brennan, Michael J

    2010-11-10

    The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP) in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac, and DETP in patients with acute soft tissue injuries was included. Relevant literature was identified on MEDLINE using the search terms topical NSAIDs, diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, strain, sprain, and contusion, and from citations in retrieved articles covering the years 1978-2008. Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5-1.9). In a limited number of comparisons, topical and oral NSAIDs provided comparable pain relief, but the use of topical agents produced lower plasma drug concentrations and fewer systemic adverse events (AEs). The physical-chemical properties of diclofenac epolamine make it well suited for topical use. In patients with acute soft tissue injuries treated with DETP, clinical data report an analgesic benefit within hours of the first application, and significant pain relief relative to placebo within 3 days. Moreover, DETP displayed tolerability comparable with placebo; the most common AEs were pruritus and other application site reactions. Review of published literature suggests that DETP is generally safe and well tolerated, clinically efficacious, and a rational treatment option for patients experiencing acute pain associated with strains, sprains, and contusions, and other localized painful conditions.

  8. Topical antifungals for seborrhoeic dermatitis

    Science.gov (United States)

    Okokon, Enembe O; Verbeek, Jos H; Ruotsalainen, Jani H; Ojo, Olumuyiwa A; Bakhoya, Victor Nyange

    2015-01-01

    Background Seborrhoeic dermatitis is a chronic inflammatory skin condition that is distributed worldwide. It commonly affects the scalp, face and flexures of the body. Treatment options include antifungal drugs, steroids, calcineurin inhibitors, keratolytic agents and phototherapy. Objectives To assess the effects of antifungal agents for seborrhoeic dermatitis of the face and scalp in adolescents and adults. A secondary objective is to assess whether the same interventions are effective in the management of seborrhoeic dermatitis in patients with HIV/AIDS. Search methods We searched the following databases up to December 2014: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (2014, Issue 11), MEDLINE (from 1946), EMBASE (from 1974) and Latin American Caribbean Health Sciences Literature (LILACS) (from 1982). We also searched trials registries and checked the bibliographies of published studies for further trials. Selection criteria Randomised controlled trials of topical antifungals used for treatment of seborrhoeic dermatitis in adolescents and adults, with primary outcome measures of complete clearance of symptoms and improved quality of life. Data collection and analysis Review author pairs independently assessed eligibility for inclusion, extracted study data and assessed risk of bias of included studies. We performed fixed-effect meta-analysis for studies with low statistical heterogeneity and used a random-effects model when heterogeneity was high. Main results We included 51 studies with 9052 participants. Of these, 45 trials assessed treatment outcomes at five weeks or less after commencement of treatment, and six trials assessed outcomes over a longer time frame. We believe that 24 trials had some form of conflict of interest, such as funding by pharmaceutical companies. Among the included studies were 12 ketoconazole trials (N = 3253), 11 ciclopirox trials (N = 3029), two lithium trials (N = 141

  9. Topics in Finance Part IX--Working Capital Management

    Science.gov (United States)

    Laux, Judy

    2012-01-01

    The final topic in a series looking at financial management from a theoretical perspective, working capital management provides the focus of the current article. We investigate how three key axioms--the risk-return tradeoff, agency conflicts, and stockholder wealth maximization--relate to this activity that occupies much of the financial manager's…

  10. An enhanced model for automatically extracting topic phrase from ...

    African Journals Online (AJOL)

    The key benefit foreseen from this automatic document classification is not only related to search engines, but also to many other fields like, document organization, text filtering and semantic index managing. Key words: Keyphrase extraction, machine learning, search engine snippet, document classification, topic tracking ...

  11. Topical herbal therapies for treating osteoarthritis.

    Science.gov (United States)

    Cameron, Melainie; Chrubasik, Sigrun

    2013-05-31

    Before extraction and synthetic chemistry were invented, musculoskeletal complaints were treated with preparations from medicinal plants. They were either administered orally or topically. In contrast to the oral medicinal plant products, topicals act in part as counterirritants or are toxic when given orally. To update the previous Cochrane review of herbal therapy for osteoarthritis from 2000 by evaluating the evidence on effectiveness for topical medicinal plant products. Databases for mainstream and complementary medicine were searched using terms to include all forms of arthritis combined with medicinal plant products. We searched electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, AMED, CINAHL, ISI Web of Science, World Health Organization Clinical Trials Registry Platform) to February 2013, unrestricted by language. We also searched the reference lists from retrieved trials. Randomised controlled trials of herbal interventions used topically, compared with inert (placebo) or active controls, in people with osteoarthritis were included. Two review authors independently selected trials for inclusion, assessed the risk of bias of included studies and extracted data. Seven studies (six different medicinal plant interventions; 785 participants) were included. Single studies (five studies) and non-comparable studies (two studies) precluded pooling of results.Moderate evidence from a single study of 174 people with hand osteoarthritis indicated that treatment with Arnica extract gel probably results in similar benefits as treatment with ibuprofen (non-steroidal anti-inflammatory drug) with a similar number of adverse events. Mean pain in the ibuprofen group was 44.2 points on a 100 point scale; treatment with Arnica gel reduced the pain by 4 points after three weeks: mean difference (MD) -3.8 points (95% confidence intervals (CI) -10.1 to 2.5), absolute reduction 4% (10% reduction to 3% increase). Hand function was 7

  12. Optical systems for synchrotron radiation. Lecture 1. Introductory topics. Revision

    International Nuclear Information System (INIS)

    Howells, M.R.

    1986-02-01

    Various fundamental topics are considered which underlie the design and use of optical systems for synchrotron radiation. The point of view of linear system theory is chosen which acts as a unifying concept throughout the series. In this context the important optical quantities usually appear as either impulse response functions (Green's functions) or frequency transfer functions (Fourier Transforms of the Green's functions). Topics include the damped harmonic oscillator, free-space optical field propagation, optical properties of materials, dispersion, and the Kramers-Kronig relations

  13. Anesthesia: A Topic for Interdisciplinary Study.

    Science.gov (United States)

    Labianca, Dominick A.; Reeves, William J.

    1977-01-01

    Describes an interdisciplinary approach for teaching the topic of anesthesia as one aspect of a chemistry-oriented course for nonscience majors which focuses on timely topics such as the energy crisis and drugs. Historical treatment with the examination of literature is emphasized in teaching. (HM)

  14. Exploring Topic Structure: Coherence, Diversity and Relatedness

    NARCIS (Netherlands)

    J. He (Jiyin)

    2011-01-01

    htmlabstractThe use of topical information has long been studied in the context of information retrieval. For example, grouping search results into topical categories enables more effective information presentation to users, while grouping documents in a collection can lead to efficient information

  15. Topical Treatment of Degenerative Knee Osteoarthritis.

    Science.gov (United States)

    Meng, Zengdong; Huang, Rongzhong

    2018-01-01

    This article reviews topical management strategies for degenerative osteoarthritis (OA) of the knee. A search of Pubmed, Embase and the Cochrane library using MeSH terms including "topical," "treatment," "knee" and "osteoarthritis" was carried out. Original research and review articles on the effectiveness and safety, recommendations from international published guidelines and acceptability studies of topical preparations were included. Current topical treatments included for the management of knee OA include topical nonsteroidal anti-inflammatory drugs, capsaicin, salicylates and physical treatments such as hot or cold therapy. Current treatment guidelines recommend topical nonsteroidal anti-inflammatory drugs as an alternative and even first-line therapy for OA management, especially among elderly patients. Guidelines on other topical treatments vary, from recommendations against their use, to in favor as alternative or simultaneous therapy, especially for patients with contraindications to other analgesics. Although often well-tolerated and preferred by many patients, clinical care still lags in the adoption of topical treatments. Aspects of efficacy, safety and patient quality of life data require further research. Copyright © 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  16. Topical cholesterol in clofazimine induced ichthyosis

    Directory of Open Access Journals (Sweden)

    Pandey S

    1994-01-01

    Full Text Available Topical application of 10% cholesterol in petrolatum significantly (P< 0.05 controlled the development of ichthyosis in 62 patients taking 100 mg clofazimine daily for a period of 3 months. However, topical cholesterol application did not affect the lowering of serum cholesterol induced by oral clofazimine. Probable mechanism of action is being discussed.

  17. Infantile generalized hypertrichosis caused by topical minoxidil*

    Science.gov (United States)

    Rampon, Greice; Henkin, Caroline; de Souza, Paulo Ricardo Martins; de Almeida Jr, Hiram Larangeira

    2016-01-01

    Rare cases of hypertrichosis have been associated with topically applied minoxidil. We present the first reported case in the Brazilian literature of generalized hypertrichosis affecting a 5-year-old child, following use of minoxidil 5%, 20 drops a day, for hair loss. The laboratory investigation excluded hyperandrogenism and thyroid dysfunction. Topical minoxidil should be used with caution in children. PMID:26982785

  18. Infantile generalized hypertrichosis caused by topical minoxidil.

    Science.gov (United States)

    Rampon, Greice; Henkin, Caroline; de Souza, Paulo Ricardo Martins; Almeida, Hiram Larangeira de

    2016-01-01

    Rare cases of hypertrichosis have been associated with topically applied minoxidil. We present the first reported case in the Brazilian literature of generalized hypertrichosis affecting a 5-year-old child, following use of minoxidil 5%, 20 drops a day, for hair loss. The laboratory investigation excluded hyperandrogenism and thyroid dysfunction. Topical minoxidil should be used with caution in children.

  19. Aerodynamics of wind turbines emerging topics

    CERN Document Server

    Amano, R S

    2014-01-01

    Focusing on Aerodynamics of Wind Turbines with topics ranging from Fundamental to Application of horizontal axis wind turbines, this book presents advanced topics including: Basic Theory for Wind turbine Blade Aerodynamics, Computational Methods, and Special Structural Reinforcement Technique for Wind Turbine Blades.

  20. Correlated Topic Vector for Scene Classification.

    Science.gov (United States)

    Wei, Pengxu; Qin, Fei; Wan, Fang; Zhu, Yi; Jiao, Jianbin; Ye, Qixiang

    2017-07-01

    Scene images usually involve semantic correlations, particularly when considering large-scale image data sets. This paper proposes a novel generative image representation, correlated topic vector, to model such semantic correlations. Oriented from the correlated topic model, correlated topic vector intends to naturally utilize the correlations among topics, which are seldom considered in the conventional feature encoding, e.g., Fisher vector, but do exist in scene images. It is expected that the involvement of correlations can increase the discriminative capability of the learned generative model and consequently improve the recognition accuracy. Incorporated with the Fisher kernel method, correlated topic vector inherits the advantages of Fisher vector. The contributions to the topics of visual words have been further employed by incorporating the Fisher kernel framework to indicate the differences among scenes. Combined with the deep convolutional neural network (CNN) features and Gibbs sampling solution, correlated topic vector shows great potential when processing large-scale and complex scene image data sets. Experiments on two scene image data sets demonstrate that correlated topic vector improves significantly the deep CNN features, and outperforms existing Fisher kernel-based features.

  1. Topic Prominence in Chinese EFL Learners' Interlanguage

    Science.gov (United States)

    Li, Shaopeng; Yang, Lianrui

    2014-01-01

    The present study aims to investigate the general characteristics of topicprominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from a discourse perspective. Topic structures mainly appear in Chinese discourse in the form of topic chains (Wang, 2002; 2004). The…

  2. Fostering Topic Knowledge: Essential for Academic Writing

    Science.gov (United States)

    Proske, Antje; Kapp, Felix

    2013-01-01

    Several researchers emphasize the role of the writer's topic knowledge for writing. In academic writing topic knowledge is often constructed by studying source texts. One possibility to support that essential phase of the writing process is to provide interactive learning questions which facilitate the construction of an adequate situation…

  3. Topics on Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Directorate (NVE). To prevent cross-subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. Chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently coordinate the

  4. Topics in Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Directorate (NVE). To prevent cross-subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. To start with, chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently

  5. Topics on Electricity Transmission Pricing

    International Nuclear Information System (INIS)

    Bjoerndal, Mette

    2000-02-01

    -subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. To start with, chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently coordinate the allocation of transmission

  6. Topical minoxidil in the treatment of alopecia areata.

    Science.gov (United States)

    Fenton, D A; Wilkinson, J D

    1983-01-01

    A modified double blind crossover study was performed to assess the effect of 1% topical minoxidil as compared with placebo in 30 patients with alopecia areata and alopecia totalis. The active preparation produced a highly significant incidence of hair regrowth. A cosmetically acceptable response was noted in 16 patients. No side effects were seen. The study confirmed that topical minoxidil will induce new hair growth in alopecia areata but that it is less likely to do so in more severe and extensive disease. Furthermore, patients with alopecia universalis and totalis may not respond at all. Nevertheless, as compared with other drugs minoxidil applied topically is relatively non-toxic, is easy to use, and has no systemic or local side effects. Images p1016-a PMID:6412929

  7. Learning Supervised Topic Models for Classification and Regression from Crowds.

    Science.gov (United States)

    Rodrigues, Filipe; Lourenco, Mariana; Ribeiro, Bernardete; Pereira, Francisco C

    2017-12-01

    The growing need to analyze large collections of documents has led to great developments in topic modeling. Since documents are frequently associated with other related variables, such as labels or ratings, much interest has been placed on supervised topic models. However, the nature of most annotation tasks, prone to ambiguity and noise, often with high volumes of documents, deem learning under a single-annotator assumption unrealistic or unpractical for most real-world applications. In this article, we propose two supervised topic models, one for classification and another for regression problems, which account for the heterogeneity and biases among different annotators that are encountered in practice when learning from crowds. We develop an efficient stochastic variational inference algorithm that is able to scale to very large datasets, and we empirically demonstrate the advantages of the proposed model over state-of-the-art approaches.

  8. Topical diclofenac in the treatment of osteoarthritis of the knee

    Directory of Open Access Journals (Sweden)

    Niklas Schuelert

    2011-02-01

    Full Text Available Niklas Schuelert, Fiona A Russell, Jason J McDougallDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaAbstract: Osteoarthritis (OA is a common disease that affects millions of people worldwide. As there is no cure for OA, drug treatment to relieve symptoms is the main form of management. Nonsteroidal anti-inflammatory drugs (NSAIDs such as diclofenac are the most commonly used drugs to treat knee OA pain. Unfortunately, these agents are associated with gastrointestinal and cardiovascular risks, which limit their chronic use. Topical NSAIDs are emerging as a viable alternative for managing OA pain. Because a pharmacologically effective dose can be restricted to the site of pain, there is superfluous systemic absorption, and the risk of related adverse effects is minimized. This article reviews the currently available preclinical and clinical information on topical diclofenac for the treatment of OA pain, including data from recently published randomized controlled trials regarding the efficacy and safety of topical diclofenac. Most studies confirm topical diclofenac to be as effective as oral diclofenac with significantly reduced side effects; however, the efficacy of NSAIDs is far from optimal, and more research needs to be done to investigate the underlying mechanisms of OA in order to improve treatment options, especially for patients with NSAID-resistant OA pain.Keywords: osteoarthritis, topical diclofenac, NSAID, joint pain 

  9. 76 FR 81806 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

    Science.gov (United States)

    2011-12-29

    .... FDA-2011-N-0003] Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution... solution of ivermectin. DATES: This rule is effective December 29, 2011. FOR FURTHER INFORMATION CONTACT... ANADA 200-318 for [[Page 81807

  10. LANMAS Gap Analysis Report; TOPICAL

    International Nuclear Information System (INIS)

    Parrish, C.; Yee, W.; Okuda, V.; Watson, B.; Storch, N

    2000-01-01

    In July, 2000, the Controlled Materials Accountability and Tracking System (COMATS) Team, with the assistance of a representative of the Local Area Network Materials Accountability System (LANMAS) development team from Savannah River, performed an evaluation to enumerate and qualify differences between the current LANMAS functionality and LLNL requirements as implemented by COMATS. The differences found range from minor to serious deficiencies of LANMAS in relation to current LLNL MC and A practice. Therefore, we recommend a gradual integration of LANMAS into a hybrid system which uses LANMAS to satisfy DOE/NNSA MC and A and reporting requirements and uses COMATS to satisfy LLNL-specific MC and A and operational requirements

  11. Topics in elementary scattering theory

    International Nuclear Information System (INIS)

    Imrie, D.C.

    1980-01-01

    In these lectures a summary is given of some of the fundamental ideas and formalism used to describe and understand the interactions of elementary particles. A brief review of relativistic kinematics is followed by a discussion of Lorentz-invariant variables for describing two-body processes, phase space and plots, such as the Dalitz plot, which can be used to study some aspects of the dynamics of an interaction, relatively free from kinematic complications. A general description of scattering and decay is given and then, more specifically, some aspects of two-body interactions in the absence of spin are discussed. Finally, complications that arise when particle spin has to be taken into account are considered. (U.K.)

  12. Problematic topic transitions in dysarthric conversation.

    Science.gov (United States)

    Bloch, Steven; Saldert, Charlotta; Ferm, Ulrika

    2015-01-01

    This study examined the nature of topic transition problems associated with acquired progressive dysarthric speech in the everyday conversation of people with motor neurone disease. Using conversation analytic methods, a video collection of five naturally occurring problematic topic transitions was identified, transcribed and analysed. These were extracted from a main collection of over 200 other-initiated repair sequences and a sub-set of 15 problematic topic transition sequences. The sequences were analysed with reference to how the participants both identified and resolved the problems. Analysis revealed that topic transition by people with dysarthria can prove problematic. Conversation partners may find transitions problematic not only because of speech intelligibility but also because of a sequential disjuncture between the dysarthric speech turn and whatever topic has come prior. In addition the treatment of problematic topic transition as a complaint reveals the potential vulnerability of people with dysarthria to judgements of competence. These findings have implications for how dysarthria is conceptualized and how specific actions in conversation, such as topic transition, might be suitable targets for clinical intervention.

  13. Joint Group and Topic Discovery from Relations and Text

    National Research Council Canada - National Science Library

    McCallum, Andrew; Wang, Xuerui; Mohanty, Natasha

    2006-01-01

    .... We present experimental results on two large data sets: sixteen years of bills put before the U.S. Senate, comprising their corresponding text and voting records, and 43 years of similar data from the United Nations...

  14. Methods of qualitative theory of differential equations and related topics

    CERN Document Server

    Lerman, L; Shilnikov, L

    2000-01-01

    Dedicated to the memory of Professor E. A. Leontovich-Andronova, this book was composed by former students and colleagues who wished to mark her contributions to the theory of dynamical systems. A detailed introduction by Leontovich-Andronova's close colleague, L. Shilnikov, presents biographical data and describes her main contribution to the theory of bifurcations and dynamical systems. The main part of the volume is composed of research papers presenting the interests of Leontovich-Andronova, her students and her colleagues. Included are articles on traveling waves in coupled circle maps, b

  15. Gabor frames on locally compact abelian groups and related topics

    DEFF Research Database (Denmark)

    Jakobsen, Mads Sielemann

    This thesis consists of four papers. The first one introduces generalized translation invariant systems and considers their frame properties, the second and third paper give new results on the theory of Gabor frames, and the fourth is a review paper with proofs and new results on the Feichtinger......- and shearlet-type and for (generalized) shift-invariant systems and their continuous formulations. This thesis advances the theory of both separable and non-separable, discrete, semicontinuous and continuous Gabor systems. In particular, the well established structure theory for separable lattice Gabor frames...... and Gabor Riesz bases. The theory of GTI systems and Gabor frames in this thesis is developed and presented in the setting of locally compact abelian groups, however, even in the euclidean setting the results given here improve the existing theory. Finally, the thesis contains a review paper with proofs...

  16. Investigations on detonation shock dynamics and related topics. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, D.S. [Univ. of Illinois, Urbana, IL (United States). Dept. of Theoretical and Applied Mechanics

    1993-11-01

    This document is a final report that summarizes the research findings and research activities supported by the subcontract DOE-LANL-9-XG8-3931P-1 between the University of Illinois (D. S. Stewart Principal Investigator) and the University of California (Los Alamos National Laboratory, M-Division). The main focus of the work has been on investigations of Detonation Shock Dynamics. A second emphasis has been on modeling compaction of energetic materials and deflagration to detonation in those materials. The work has led to a number of extensions of the theory of Detonation Shock Dynamics (DSD) and its application as an engineering design method for high explosive systems. The work also enhanced the hydrocode capabilities of researchers in M-Division by modifications to CAVEAT, an existing Los Alamos hydrocode. Linear stability studies of detonation flows were carried out for the purpose of code verification. This work also broadened the existing theory for detonation. The work in this contract has led to the development of one-phase models for dynamic compaction of porous energetic materials and laid the groundwork for subsequent studies. Some work that modeled the discrete heterogeneous behavior of propellant beds was also performed. The contract supported the efforts of D. S. Stewart and a Postdoctoral student H. I. Lee at the University of Illinois.

  17. Axiomatic derivation of Feynman rules and related topics

    International Nuclear Information System (INIS)

    Dorfmeister, G.K.

    1992-01-01

    Previous results in axiomatic field theory by Steinmann and Epstein-Glaser establish the existence of the retarded and time ordered Green's functions in every order of perturbation. To connect these Green's functions with the ones calculated in canonical field theories via the Feynman rules, one has to consistently build them not just for every order of perturbation but for each specific graph. (open-quotes Consisentlyclose quotes means here that the Green functions associated with two open-quotes smallclose quotes graphs build up to the Green's functions of the open-quotes bigclose quotes graph formed by connecting the two open-quotes smallclose quotes ones). This paper shows that this can indeed be done; that in this sense the Feynman rules of perturbative Lagrangian field theory can be derived from the abstract, but physically very basic, principles of axiomatic field theory. All results hold only for massive field theories. The LSZ formalism, to the best knowledge of the author, has so far not been modified to admit mass zero fields. To make the representation simpler and more transparent, the author restricts the discussion to a single component, scalar Φ 4 interaction which is a part of the Standard Model of Particle Physics. Motivated by its role in particle physics, the author complements the perturbative study of Φ 4 -theory by reviewing the status of non-perturbative solutions to the theory in the final chapter

  18. Recent radioactive ion beam program at RIKEN and related topics

    Indian Academy of Sciences (India)

    Recent experimental programs at RIKEN concerning RI beams are reviewed. RIKEN has the ring cyclotron (RRC) with high intense heavy-ion beams and large acceptance fragment separator, RIPS. The complex can provide high intense RI-beams. By using the high intense RI-beams, a variety of experiments have been ...

  19. A statement on safety and related topics respecting nuclear power

    International Nuclear Information System (INIS)

    1982-01-01

    It is stated that nuclear power is remarkably safe and certainly safer than power from coal or oil. Waste presents no genuine problem in terms of storage, disposal or quantity while the ecological environmental impact is less than that of virtually all possible alternatives. Use of nuclear power can make the UK independent of external politically unreliable sources of energy. There are ethical arguments for choosing it in preference to coal or oil and it is broadly irrelevant to the question of nuclear proliferation. (U.K.)

  20. Topical problems related to the pollution of the Baltic Sea

    International Nuclear Information System (INIS)

    1991-01-01

    This report sums up the current state of knowledge on the pollution of the Baltic Sea as an aquatic system. Mineral oil hydrocarbons, halogenated hydrocarbons, heavy metals and radionuclides are pinpointed as the main causes of pollution. Furthermore, the work presents the results of investigations carried through for several years on the contamination of salt-water fishes. The causes and consequences of nutrient accumulation in the Baltic Sea are discussed. (VT) [de

  1. A Panorama of Modern Operator Theory and Related Topics

    CERN Document Server

    Dym, Harry; Lancaster, Peter

    2012-01-01

    This book is dedicated to the memory of Israel Gohberg (1928-2009) - one of the great mathematicians of our time - who inspired innumerable fellow mathematicians and directed many students. The volume reflects the wide spectrum of Gohberg's mathematical interests. It consists of more than 25 invited and peer-reviewed original research papers written by his former students, co-authors and friends. Included are contributions to single and multivariable operator theory, commutative and non-commutative Banach algebra theory, the theory of matrix polynomials and analytic vector-valued functions, se

  2. Recent radioactive ion beam program at RIKEN and related topics

    Indian Academy of Sciences (India)

    Keywords. RIKEN; radioactive ion beams; magic numbers. PACS No. 21.10.-k. 1. Introduction. In RIKEN, there are several heavy ion accelerators. Main accelerator is the RIKEN ring cyclotron (RRC) with K = 540, that has been operated from 1986. The RRC has two injectors; one is heavy ion linear accelerator that has been ...

  3. 9th Workshop on Stochastic Analysis and Related Topics

    CERN Document Server

    Decreusefond, Laurent; Stochastic Analysis and Related Topics

    2012-01-01

    Since the early eighties, Ali Suleyman Ustunel has been one of the main contributors to the field of Malliavin calculus. In a workshop held in Paris, June 2010 several prominent researchers gave exciting talks in honor of his 60th birthday. The present volume includes scientific contributions from this workshop. Probability theory is first and foremost aimed at solving real-life problems containing randomness. Markov processes are one of the key tools for modeling that plays a vital part concerning such problems. Contributions on inventory control, mutation-selection in genetics and public-pri

  4. Relativity

    CERN Document Server

    Einstein, Albert

    2013-01-01

    Time magazine's ""Man of the Century"", Albert Einstein is the founder of modern physics and his theory of relativity is the most important scientific idea of the modern era. In this short book, Einstein explains, using the minimum of mathematical terms, the basic ideas and principles of the theory that has shaped the world we live in today. Unsurpassed by any subsequent books on relativity, this remains the most popular and useful exposition of Einstein's immense contribution to human knowledge.With a new foreword by Derek Raine.

  5. Topics in supergravity and string theory

    International Nuclear Information System (INIS)

    Eastaugh, A.G.

    1987-01-01

    The first topic covered in this dissertation concerns the harmonic expansion technique and its application to the dimensional compactification of higher dimensional supergravity. A simple example is given to explain the method and then the method is applied to the problem of obtaining the mass spectrum of the squashed seven-sphere compactification of eleven dimensional supergravity. The second topic concerns the application of Fujikawa's method of anomaly calculation to the calculation of the critical dimension of various string models. The third topic is a study and explicit calculation of the Fock space representation of the vertex in Witten's formulation of the interacting open bosonic string field theory

  6. Control of pain with topical plant medicines

    Directory of Open Access Journals (Sweden)

    James David Adams Jr.

    2015-04-01

    Full Text Available Pain is normally treated with oral nonsteroidal anti-inflammatory agents and opioids. These drugs are dangerous and are responsible for many hospitalizations and deaths. It is much safer to use topical preparations made from plants to treat pain, even severe pain. Topical preparations must contain compounds that penetrate the skin, inhibit pain receptors such as transient receptor potential cation channels and cyclooxygenase-2, to relieve pain. Inhibition of pain in the skin disrupts the pain cycle and avoids exposure of internal organs to large amounts of toxic compounds. Use of topical pain relievers has the potential to save many lives, decrease medical costs and improve therapy.

  7. Selected topics in neutrino physics

    International Nuclear Information System (INIS)

    Mann, A.K.

    1979-01-01

    Lectures on the contribution of neutrino physics to the recent development in particle physics are presented. In the introductory lecture prospects of investigations of neutrino physics and its application to astrophysics and cosmology are briefly given. Some problems on the ωsub(μ)(anti ωsub(μ))+N → ωsub(μ)(anti ωsub(μ))+X semileptonic inclusiVe reactions and the ωsub(μ)(anti ωsub(μ))+p → ωsub(μ)(anti ωsub(μ))+p elastic semileptonic neUtral current processes are discussed in the second lecture. Particular attention in the third lecture is paid to the ωsub(μ)(anti ωsub(μ))+N →μ - (μ + )+X reactions studied by physicists from Harvard, Pensylvania, Wisconsin and Fermilab. The discrepancy between experiments and theoretical predictions is believed to be connect with systematic errors in their experiments which they have failed to take into account. The last lecture is devoted to dimuon and trimuon production by neutrinos. It is considered that neutrino-induced multimuons are probe of new particle production and decay with a relatively clean process picture and well understood background

  8. Topics in Cubic Special Geometry

    CERN Document Server

    Bellucci, Stefano; Roychowdhury, Raju

    2011-01-01

    We reconsider the sub-leading quantum perturbative corrections to N=2 cubic special Kaehler geometries. Imposing the invariance under axion-shifts, all such corrections (but the imaginary constant one) can be introduced or removed through suitable, lower unitriangular symplectic transformations, dubbed Peccei-Quinn (PQ) transformations. Since PQ transformations do not belong to the d=4 U-duality group G4, in symmetric cases they generally have a non-trivial action on the unique quartic invariant polynomial I4 of the charge representation R of G4. This leads to interesting phenomena in relation to theory of extremal black hole attractors; namely, the possibility to make transitions between different charge orbits of R, with corresponding change of the supersymmetry properties of the supported attractor solutions. Furthermore, a suitable action of PQ transformations can also set I4 to zero, or vice versa it can generate a non-vanishing I4: this corresponds to transitions between "large" and "small" charge orbit...

  9. Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

    OpenAIRE

    Sung-Chien Lin

    2014-01-01

    In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results ...

  10. Special Topics in Radiography. Chapter 10

    Energy Technology Data Exchange (ETDEWEB)

    Mclean, I. D. [International Atomic Energy Agency, Vienna (Austria); Shepherd, J. A. [University of California at San Francisco, San Francisco, United States of America (United States)

    2014-09-15

    Up to this point, this handbook has described the use of X rays to form 2-D medical images of the 3-D patient. This process of reducing patient information by one dimension results in an image of superimposed tissues where important information might be obscured. Chapter 11 begins a section of the book involving the creation of cross-sectional medical images through computed tomography (CT), ultrasound and magnetic resonance imaging (MRI). This Chapter describes a number of special X ray imaging modalities and their associated techniques, and forms a transition between projection and cross-sectional imaging. The first of these special topics is dental radiography, which is characterized by a diversity of technology and innovation. The common intraoral radiograph of a single tooth has seen little fundamental change since the time of Roentgen and is, today, along with the simple chest radiograph, the most commonly performed radiographic examination. By contrast, the challenge to create an image of all the teeth simultaneously has placed dentistry at the cutting edge of technology, through the development of panographic techniques and, most recently, with the application of cone beam CT (CBCT). Moreover, the small size of the tooth and the consequent reduced need for X ray generation power promotes equipment mobility. The effect of the need for equipment mobility also forms a special topic that is examined in this chapter. Quantification of the composition of the body is another special X ray imaging technique. Dual energy X ray absorptiometry (DXA) is primarily used to derive the mass of one material in the presence of another, through knowledge of their unique X ray attenuation at different energies. DXA’s primary commercial application has been to measure body mineral density as an assessment of fracture risk and to diagnose osteoporosis; thus, the X ray energies used are optimized for bone density assessment. Currently, there are estimated to be over 50 000

  11. 152 TOPICALIZATION AND PASSIVISATION IN THE ENGLISH ...

    African Journals Online (AJOL)

    It is believed that this study will further highlight some of the basic ... The objective of the study is to explore topicalization and passivisation in the English Language ..... Radford, R. Transformational Syntax A Student Guide to Chomsky's ...

  12. SETI: A good introductory physics topic

    Science.gov (United States)

    Hobson, Art

    1997-04-01

    If America is to achieve the science literacy that is essential to industrialized democracy, all students must study such topics as scientific methodology, pseudoscience, ozone depletion, and global warming. My large-enrollment liberal-arts physics course covers the great principles of physics along with several such philosophical and societal topics. It is easy to include the interdisciplinary context of physics in courses for non-scientists, because these courses are flexible, conceptual, and taught to students whose interests span a broad range. Students find these topics relevant and fascinating, leading to large enrollments by non-scientists even in courses labeled ''physics.'' I will discuss my approach to teaching the search for extra-terrestrial intelligence (SETI), a topic with lots of good physics and with connections to scientific methodology and pseudoscience. A textbook for this kind of course has been published, Physics: Concepts and Connections (Prentice-Hall, 1995).

  13. Section 608 Technician Certification Test Topics

    Science.gov (United States)

    Identifies some of the topics covered on Section 608 Technician Certification tests such as ozone depletion, the Clean Air Act and Montreal Protocol, Substitute Refrigerants and oils, Refrigeration and Recovery Techniques.

  14. Web Enabled DROLS Verity TopicSets

    National Research Council Canada - National Science Library

    Tong, Richard

    1999-01-01

    The focus of this effort has been the design and development of automatically generated TopicSets and HTML pages that provide the basis of the required search and browsing capability for DTIC's Web Enabled DROLS System...

  15. Atopic dermatitis: tacrolimus vs. topical corticosteroid use

    African Journals Online (AJOL)

    Atopic dermatitis (AD) is an inflammatory skin disease that is characterised .... effective in the treatment of AD.5. Although ..... original steroid preparations,20 the cost-effectiveness of ... Topical corticosteroids [homepage on the Internet]. c2010.

  16. Data Mining Thesis Topics in Finland

    OpenAIRE

    Bajo Rouvinen, Ari

    2017-01-01

    The Theseus open repository contains metadata about more than 100,000 thesis publications from the different universities of applied sciences in Finland. Different data mining techniques were applied to the Theseus dataset to build a web application to explore thesis topics and degree programmes using different libraries in Python and JavaScript. Thesis topics were extracted from manually annotated keywords by the authors and curated subjects by the librarians. During the project, the quality...

  17. Is topical haloperidol a useful glaucoma treatment?

    OpenAIRE

    Lavin, M. J.; Andrews, V.

    1986-01-01

    A randomised, double blind, single dose study of topical haloperidol, a dopamine receptor blocking drug, was performed on 20 healthy volunteers. After its administration a modest reduction in intraocular pressure was recorded over the six-hour study period, but the difference was not significant at the p less than 0.05 level. Although dopamine blocking agents are effective in reducing intraocular pressure in experimental animals, topical haloperidol appears unlikely to be clinically useful in...

  18. Topical Melatonin for Treatment of Androgenetic Alopecia

    OpenAIRE

    Fischer, Tobias W; Tr?eb, Ralph M; H?nggi, Gabriella; Innocenti, Marcello; Elsner, Peter

    2012-01-01

    Background: In the search for alternative agents to oral finasteride and topical minoxidil for the treatment of androgenetic alopecia (AGA), melatonin, a potent antioxidant and growth modulator, was identified as a promising candidate based on in vitro and in vivo studies. Materials and Methods: One pharmacodynamic study on topical application of melatonin and four clinical pre-post studies were performed in patients with androgenetic alopecia or general hair loss and evaluated by standardise...

  19. Topical steroid addiction in atopic dermatitis

    Directory of Open Access Journals (Sweden)

    Fukaya M

    2014-10-01

    Full Text Available Mototsugu Fukaya,1 Kenji Sato,2 Mitsuko Sato,3 Hajime Kimata,4 Shigeki Fujisawa,5 Haruhiko Dozono,6 Jun Yoshizawa,7 Satoko Minaguchi8 1Tsurumai Kouen Clinic, Nagoya, 2Department of Dermatology, Hannan Chuo Hospital, Osaka, 3Sato Pediatric Clinic, Osaka, 4Kimata Hajime Clinic, Osaka, 5Fujisawa Dermatology Clinic, Tokyo, 6Dozono Medical House, Kagoshima, 7Yoshizawa Dermatology Clinic, Yokohama, 8Department of Dermatology, Kounosu Kyousei Hospital, Saitama, Japan Abstract: The American Academy of Dermatology published a new guideline regarding topical therapy in atopic dermatitis in May 2014. Although topical steroid addiction or red burning skin syndrome had been mentioned as possible side effects of topical steroids in a 2006 review article in the Journal of the American Academy of Dermatology, no statement was made regarding this illness in the new guidelines. This suggests that there are still controversies regarding this illness. Here, we describe the clinical features of topical steroid addiction or red burning skin syndrome, based on the treatment of many cases of the illness. Because there have been few articles in the medical literature regarding this illness, the description in this article will be of some benefit to better understand the illness and to spur discussion regarding topical steroid addiction or red burning skin syndrome. Keywords: topical steroid addiction, atopic dermatitis, red burning skin syndrome, rebound, corticosteroid, eczema

  20. Supporting inter-topic entity search for biomedical Linked Data based on heterogeneous relationships.

    Science.gov (United States)

    Zong, Nansu; Lee, Sungin; Ahn, Jinhyun; Kim, Hong-Gee

    2017-08-01

    The keyword-based entity search restricts search space based on the preference of search. When given keywords and preferences are not related to the same biomedical topic, existing biomedical Linked Data search engines fail to deliver satisfactory results. This research aims to tackle this issue by supporting an inter-topic search-improving search with inputs, keywords and preferences, under different topics. This study developed an effective algorithm in which the relations between biomedical entities were used in tandem with a keyword-based entity search, Siren. The algorithm, PERank, which is an adaptation of Personalized PageRank (PPR), uses a pair of input: (1) search preferences, and (2) entities from a keyword-based entity search with a keyword query, to formalize the search results on-the-fly based on the index of the precomputed Individual Personalized PageRank Vectors (IPPVs). Our experiments were performed over ten linked life datasets for two query sets, one with keyword-preference topic correspondence (intra-topic search), and the other without (inter-topic search). The experiments showed that the proposed method achieved better search results, for example a 14% increase in precision for the inter-topic search than the baseline keyword-based search engine. The proposed method improved the keyword-based biomedical entity search by supporting the inter-topic search without affecting the intra-topic search based on the relations between different entities. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Recent advances and perspectives in topical oral anesthesia.

    Science.gov (United States)

    Franz-Montan, Michelle; Ribeiro, Lígia Nunes de Morais; Volpato, Maria Cristina; Cereda, Cintia Maria Saia; Groppo, Francisco Carlos; Tofoli, Giovana Randomille; de Araújo, Daniele Ribeiro; Santi, Patrizia; Padula, Cristina; de Paula, Eneida

    2017-05-01

    Topical anesthesia is widely used in dentistry to reduce pain caused by needle insertion and injection of the anesthetic. However, successful anesthesia is not always achieved using the formulations that are currently commercially available. As a result, local anesthesia is still one of the procedures that is most feared by dental patients. Drug delivery systems (DDSs) provide ways of improving the efficacy of topical agents. Areas covered: An overview of the structure and permeability of oral mucosa is given, followed by a review of DDSs designed for dental topical anesthesia and their related clinical trials. Chemical approaches to enhance permeation and anesthesia efficacy, or to promote superficial anesthesia, include nanostructured carriers (liposomes, cyclodextrins, polymeric nanoparticle systems, solid lipid nanoparticles, and nanostructured lipid carriers) and different pharmaceutical dosage forms (patches, bio- and mucoadhesive systems, and hydrogels). Physical methods include pre-cooling, vibration, iontophoresis, and microneedle arrays. Expert opinion: The combination of different chemical and physical methods is an attractive option for effective topical anesthesia in oral mucosa. This comprehensive review should provide the readers with the most relevant options currently available to assist pain-free dental anesthesia. The findings should be considered for future clinical trials.

  2. Characterizing interdisciplinarity of researchers and research topics using web search engines.

    Science.gov (United States)

    Sayama, Hiroki; Akaishi, Jin

    2012-01-01

    Researchers' networks have been subject to active modeling and analysis. Earlier literature mostly focused on citation or co-authorship networks reconstructed from annotated scientific publication databases, which have several limitations. Recently, general-purpose web search engines have also been utilized to collect information about social networks. Here we reconstructed, using web search engines, a network representing the relatedness of researchers to their peers as well as to various research topics. Relatedness between researchers and research topics was characterized by visibility boost-increase of a researcher's visibility by focusing on a particular topic. It was observed that researchers who had high visibility boosts by the same research topic tended to be close to each other in their network. We calculated correlations between visibility boosts by research topics and researchers' interdisciplinarity at the individual level (diversity of topics related to the researcher) and at the social level (his/her centrality in the researchers' network). We found that visibility boosts by certain research topics were positively correlated with researchers' individual-level interdisciplinarity despite their negative correlations with the general popularity of researchers. It was also found that visibility boosts by network-related topics had positive correlations with researchers' social-level interdisciplinarity. Research topics' correlations with researchers' individual- and social-level interdisciplinarities were found to be nearly independent from each other. These findings suggest that the notion of "interdisciplinarity" of a researcher should be understood as a multi-dimensional concept that should be evaluated using multiple assessment means.

  3. Antimicrobial topical agents used in the vagina.

    Science.gov (United States)

    Frey Tirri, Brigitte

    2011-01-01

    Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effective against bacteria, fungi, viruses and protozoa. Topical treatments can be prescribed for a wide variety of vaginal infections. Many bacterial infections, such as bacterial vaginosis, desquamative inflammatory vaginitis or, as some European authors call it, aerobic vaginitis as well as infection with Staphylococcus aureus or group A streptococci, may be treated in this way. Candida vulvovaginitis is a fungal infection that is very amenable to topical treatment. The most common viral infections which can be treated with topical medications are condylomata acuminata and herpes simplex. The most often encountered protozoal vaginitis, which is caused by Trichomonas vaginalis, may be susceptible to topical medications, although this infection is treated systemically. This chapter covers the wide variety of commonly used topical antimicrobial agents for these diseases and focuses on the individual therapeutic agents and their clinical efficacy. In addition, potential difficulties that can occur in practice, as well as the usage of these medications in the special setting of pregnancy, are described in this chapter. Copyright © 2011 S. Karger AG, Basel.

  4. Development and Evaluation of Topical Gabapentin Formulations

    Directory of Open Access Journals (Sweden)

    Christopher J. Martin

    2017-08-01

    Full Text Available Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w gabapentin 0.75% (w/w Carbopol® hydrogels containing 5% (w/w DMSO or 70% (w/w ethanol and a compounded 10% (w/w gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations.

  5. Development and Evaluation of Topical Gabapentin Formulations

    Science.gov (United States)

    Alcock, Natalie; Hiom, Sarah; Birchall, James C.

    2017-01-01

    Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w) gabapentin 0.75% (w/w) Carbopol® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol and a compounded 10% (w/w) gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations. PMID:28867811

  6. Task-Driven Comparison of Topic Models.

    Science.gov (United States)

    Alexander, Eric; Gleicher, Michael

    2016-01-01

    Topic modeling, a method of statistically extracting thematic content from a large collection of texts, is used for a wide variety of tasks within text analysis. Though there are a growing number of tools and techniques for exploring single models, comparisons between models are generally reduced to a small set of numerical metrics. These metrics may or may not reflect a model's performance on the analyst's intended task, and can therefore be insufficient to diagnose what causes differences between models. In this paper, we explore task-centric topic model comparison, considering how we can both provide detail for a more nuanced understanding of differences and address the wealth of tasks for which topic models are used. We derive comparison tasks from single-model uses of topic models, which predominantly fall into the categories of understanding topics, understanding similarity, and understanding change. Finally, we provide several visualization techniques that facilitate these tasks, including buddy plots, which combine color and position encodings to allow analysts to readily view changes in document similarity.

  7. Special topics in infrared interferometry. [Michelson interferometer development

    Science.gov (United States)

    Hanel, R. A.

    1985-01-01

    Topics in IR interferometry related to the development of a Michelson interferometer are treated. The selection and reading of the signal from the detector to the analog to digital converter is explained. The requirements for the Michelson interferometer advance speed are deduced. The effects of intensity modulation on the interferogram are discussed. Wavelength and intensity calibration of the interferometer are explained. Noise sources (Nyquist or Johnson noise, phonon noise), definitions of measuring methods of noise, and noise measurements are presented.

  8. Nowcasting using news topics Big Data versus big bank

    OpenAIRE

    Thorsrud, Leif Anders

    2016-01-01

    The agents in the economy use a plethora of high frequency information, including news media, to guide their actions and thereby shape aggregate economic fluctuations. Traditional nowcasting approches have to a relatively little degree made use of such information. In this paper, I show how unstructured textual information in a business newspaper can be decomposed into daily news topics and used to nowcast quarterly GDP growth. Compared with a big bank of experts, here represented by o cial c...

  9. LDA-Based Unified Topic Modeling for Similar TV User Grouping and TV Program Recommendation.

    Science.gov (United States)

    Pyo, Shinjee; Kim, Eunhui; Kim, Munchurl

    2015-08-01

    Social TV is a social media service via TV and social networks through which TV users exchange their experiences about TV programs that they are viewing. For social TV service, two technical aspects are envisioned: grouping of similar TV users to create social TV communities and recommending TV programs based on group and personal interests for personalizing TV. In this paper, we propose a unified topic model based on grouping of similar TV users and recommending TV programs as a social TV service. The proposed unified topic model employs two latent Dirichlet allocation (LDA) models. One is a topic model of TV users, and the other is a topic model of the description words for viewed TV programs. The two LDA models are then integrated via a topic proportion parameter for TV programs, which enforces the grouping of similar TV users and associated description words for watched TV programs at the same time in a unified topic modeling framework. The unified model identifies the semantic relation between TV user groups and TV program description word groups so that more meaningful TV program recommendations can be made. The unified topic model also overcomes an item ramp-up problem such that new TV programs can be reliably recommended to TV users. Furthermore, from the topic model of TV users, TV users with similar tastes can be grouped as topics, which can then be recommended as social TV communities. To verify our proposed method of unified topic-modeling-based TV user grouping and TV program recommendation for social TV services, in our experiments, we used real TV viewing history data and electronic program guide data from a seven-month period collected by a TV poll agency. The experimental results show that the proposed unified topic model yields an average 81.4% precision for 50 topics in TV program recommendation and its performance is an average of 6.5% higher than that of the topic model of TV users only. For TV user prediction with new TV programs, the average

  10. Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

    Directory of Open Access Journals (Sweden)

    Sung-Chien Lin

    2014-07-01

    Full Text Available In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results of this study show that when the number of topics was set to 10, the topic model has the smallest perplexity. Although data scopes and analysis methodsare different to previous studies, the generating topics of this study are consistent with those results produced by analyses of experts. Empirical case studies and measurements of bibliometric indicators were concerned important in every year during the whole analytic period, and the field was increasing stability. Both the two core journals broadly paid more attention to all of the topics in the field of Informetrics. The Journal of Informetricsput particular emphasis on construction and applications ofbibliometric indicators and Scientometrics focused on the evaluation and the factors of productivity of countries, institutions, domains, and journals.

  11. Lecture Notes on Topics in Accelerator Physics

    Energy Technology Data Exchange (ETDEWEB)

    Chao, Alex W.

    2002-11-15

    These are lecture notes that cover a selection of topics, some of them under current research, in accelerator physics. I try to derive the results from first principles, although the students are assumed to have an introductory knowledge of the basics. The topics covered are: (1) Panofsky-Wenzel and Planar Wake Theorems; (2) Echo Effect; (3) Crystalline Beam; (4) Fast Ion Instability; (5) Lawson-Woodward Theorem and Laser Acceleration in Free Space; (6) Spin Dynamics and Siberian Snakes; (7) Symplectic Approximation of Maps; (8) Truncated Power Series Algebra; and (9) Lie Algebra Technique for nonlinear Dynamics. The purpose of these lectures is not to elaborate, but to prepare the students so that they can do their own research. Each topic can be read independently of the others.

  12. Lecture Notes on Topics in Accelerator Physics

    International Nuclear Information System (INIS)

    Chao, Alex W.

    2002-01-01

    These are lecture notes that cover a selection of topics, some of them under current research, in accelerator physics. I try to derive the results from first principles, although the students are assumed to have an introductory knowledge of the basics. The topics covered are: (1) Panofsky-Wenzel and Planar Wake Theorems; (2) Echo Effect; (3) Crystalline Beam; (4) Fast Ion Instability; (5) Lawson-Woodward Theorem and Laser Acceleration in Free Space; (6) Spin Dynamics and Siberian Snakes; (7) Symplectic Approximation of Maps; (8) Truncated Power Series Algebra; and (9) Lie Algebra Technique for nonlinear Dynamics. The purpose of these lectures is not to elaborate, but to prepare the students so that they can do their own research. Each topic can be read independently of the others

  13. Risk assessment of topically applied products

    DEFF Research Database (Denmark)

    Søborg, Tue; Basse, Line Hollesen; Halling-Sørensen, Bent

    2007-01-01

    The human risk of harmful substances in semisolid topical dosage forms applied topically to normal skin and broken skin, respectively, was assessed. Bisphenol A diglycidyl ether (BADGE) and three derivatives of BADGE previously quantified in aqueous cream and the UV filters 3-BC and 4-MBC were used...... as model compounds. Tolerable daily intake (TDI) values have been established for BADGE and derivatives. Endocrine disruption was chosen as endpoint for 3-BC and 4-MBC. Skin permeation of the model compounds was investigated in vitro using pig skin membranes. Tape stripping was applied to simulate broken...... parameters for estimating the risk. The immediate human risk of BADGE and derivatives in topical dosage forms was found to be low. However, local treatment of broken skin may lead to higher exposure of BADGE and derivatives compared to application to normal skin. 3-BC permeated skin at higher flux than 4-MBC...

  14. Getting Started with Topic Modeling and MALLET

    Directory of Open Access Journals (Sweden)

    Shawn Graham

    2012-09-01

    Full Text Available In this lesson you will first learn what topic modeling is and why you might want to employ it in your research. You will then learn how to install and work with the MALLET natural language processing toolkit to do so. MALLET involves modifying an environment variable (essentially, setting up a short-cut so that your computer always knows where to find the MALLET program and working with the command line (ie, by typing in commands manually, rather than clicking on icons or menus. We will run the topic modeller on some example files, and look at the kinds of outputs that MALLET installed. This will give us a good idea of how it can be used on a corpus of texts to identify topics found in the documents without reading them individually.

  15. Topical minoxidil: cardiac effects in bald man.

    Science.gov (United States)

    Leenen, F H; Smith, D L; Unger, W P

    1988-01-01

    Systemic cardiovascular effects during chronic treatment with topical minoxidil vs placebo were evaluated using a double-blind, randomized design for two parallel groups (n = 20 for minoxidil, n = 15 for placebo). During 6 months of follow-up, blood pressure did not change, whereas minoxidil increased heart rate by 3-5 beats min-1. Compared with placebo, topical minoxidil caused significant increases in LV end-diastolic volume, in cardiac output (by 0.751 min-1) and in LV mass (by 5 g m-2). We conclude that in healthy subjects short-term use of topical minoxidil is likely not to be detrimental. However, safety needs to be established regarding ischaemic symptoms in patients with coronary artery disease as well as for the possible development of LV hypertrophy in healthy subjects during years of therapy. PMID:3191000

  16. Recent topics in NMR imaging and MRI

    International Nuclear Information System (INIS)

    Watanabe, Tokuko

    2002-01-01

    NMR and NMR imaging (MRI) are finding increasing use not only in the clinical and medical fields, but also in material, physicochemical, biological, geological, industrial and environmental applications. This short review is limited to two topics: new techniques and pulse sequences and their application to non-clinical fields that may have clinical application; and new trends in MR contrast agents. The former topic addresses pulse sequence and data analysis; dynamics such as diffusion, flow, velocity and velocimetry; chemometrics; pharmacological agents; and chemotherapy; the latter topic addresses contrast agents (CA) sensitive to biochemical activity; CA based on water exchange; molecular interactions and stability of CA; characteristics of emerging CA; superparamagnetic CA; and macromolecular CA. (author)

  17. Topical anesthesia: possible risk factor for endophthalmitis after cataract extraction.

    Science.gov (United States)

    Garcia-Arumi, Jose; Fonollosa, Alex; Sararols, Laura; Fina, Francesc; Martínez-Castillo, Vicente; Boixadera, Ana; Zapata, Miguel A; Campins, Magda

    2007-06-01

    To assess the relationship between the risk for acute endophthalmitis after cataract extraction and whether certain factors, such as surgeon qualification, numerical order, duration of surgery, operating theater, and type of anesthesia (topical or retrobulbar), could be modified to decrease the risk. Single-center academic practice. Two epidemiological studies were performed: a case-control study and a retrospective cohort study. The surgical records of all patients with clinically diagnosed endophthalmitis within 30 days after cataract surgery performed between February 2002 and September 2003 were reviewed. The endophthalmitis cases were compared with 108 randomly selected controls (4 controls per case). The global incidence of endophthalmitis and the incidence according to type of anesthesia were calculated. Of 5011 cataract extractions performed, 27 cases of endophthalmitis occurred. The incidence was 5.39 per 1000 procedures. An independent statistically significant relationship was found between endophthalmitis and the use of topical anesthesia (odds ratio [OR], 11.8; 95% confidence interval [CI], 2.4-58.7) and surgery longer than 45 minutes (OR, 7.2; 95% CI, 1.7-29.7) but not between the other variables. The incidence of endophthalmitis was 1.8 per 1000 cataract extractions with retrobulbar anesthesia and 6.76 per 1000 with topical anesthesia (relative risk [RR], 3.76; 95% CI, 0.89-15.85). After the start of the study period was extended to May 2001, the incidence of endophthalmitis was 1.3 per 1000 cataract extractions with retrobulbar anesthesia and 8.7 per 1000 with topical anesthesia (RR, 6.72; 95% CI, 1.63-27.63). Results suggest that there may be an association between topical anesthesia and endophthalmitis after cataract extraction.

  18. Topics in current aerosol research (part2)

    CERN Document Server

    Hidy, G M

    1972-01-01

    Topics in Current Aerosol Research, Part 2 contains some selected articles in the field of aerosol study. The chosen topics deal extensively with the theory of diffusiophoresis and thermophoresis. Also covered in the book is the mathematical treatment of integrodifferential equations originating from the theory of aerosol coagulation. The book is the third volume of the series entitled International Reviews in Aerosol Physics and Chemistry. The text offers significant understanding of the methods employed to develop a theory for thermophoretic and diffusiophoretic forces acting on spheres in t

  19. Applied atomic and collision physics special topics

    CERN Document Server

    Massey, H S W; Bederson, Benjamin

    1982-01-01

    Applied Atomic Collision Physics, Volume 5: Special Topics deals with topics on applications of atomic collisions that were not covered in the first four volumes of the treatise. The book opens with a chapter on ultrasensitive chemical detectors. This is followed by separate chapters on lighting, magnetohydrodynamic electrical power generation, gas breakdown and high voltage insulating gases, thermionic energy converters, and charged particle detectors. Subsequent chapters deal with the operation of multiwire drift and proportional chambers and streamer chambers and their use in high energy p

  20. Radiation risks -a possible teaching topic

    International Nuclear Information System (INIS)

    Howes, R.W.

    1975-01-01

    Radiation risks has been the subject of hot debate since 1969 due in main to the energy crisis and the switch to nuclear power. Topics of this debate including; the controversy concerned with the late radiobiological effects of low level radiation, the social responsibility of modern scientists, the sometimes acrimonious discussion which has taken place over many years concerning radiation standards, and present day misgivings over the environmental aspect of the nuclear power programme, are discussed and suggestions are made of ways in which the topics could be introduced into teaching courses. (U.K.)

  1. Topic Detection Based on Weak Tie Analysis: A Case Study of LIS Research

    Directory of Open Access Journals (Sweden)

    Ling Wei

    2016-11-01

    Full Text Available Purpose: Based on the weak tie theory, this paper proposes a series of connection indicators of weak tie subnets and weak tie nodes to detect research topics, recognize their connections, and understand their evolution. Design/methodology/approach: First, keywords are extracted from article titles and preprocessed. Second, high-frequency keywords are selected to generate weak tie co-occurrence networks. By removing the internal lines of clustered sub-topic networks, we focus on the analysis of weak tie subnets' composition and functions and the weak tie nodes' roles. Findings: The research topics' clusters and themes changed yearly; the subnets clustered with technique-related and methodology-related topics have been the core, important subnets for years; while close subnets are highly independent, research topics are generally concentrated and most topics are application-related; the roles and functions of nodes and weak ties are diversified. Research limitations: The parameter values are somewhat inconsistent; the weak tie subnets and nodes are classified based on empirical observations, and the conclusions are not verified or compared to other methods. Practical implications: The research is valuable for detecting important research topics as well as their roles, interrelations, and evolution trends. Originality/value: To contribute to the strength of weak tie theory, the research translates weak and strong ties concepts to co-occurrence strength, and analyzes weak ties' functions. Also, the research proposes a quantitative method to classify and measure the topics' clusters and nodes.

  2. Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

    NARCIS (Netherlands)

    Koeneman, M. M.; Kruse, Arnold-Jan; Kooreman, L. F. S.; zur Hausen, Axel; Hopman, Anton H N; Sep, S. J. S.; Van Gorp, T.; Slangen, B. F. M.; van Beekhuizen, H. J.; de Sande, Michiel A. J. van; Gerestein, Cornelis G.; Nijman, H. W.; Kruitwagen, R. F. M. P.

    2017-01-01

    The "TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia" (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia

  3. What Patients Can Tell Us: Topic Analysis for Social Media on Breast Cancer.

    Science.gov (United States)

    Tapi Nzali, Mike Donald; Bringay, Sandra; Lavergne, Christian; Mollevi, Caroline; Opitz, Thomas

    2017-07-31

    Social media dedicated to health are increasingly used by patients and health professionals. They are rich textual resources with content generated through free exchange between patients. We are proposing a method to tackle the problem of retrieving clinically relevant information from such social media in order to analyze the quality of life of patients with breast cancer. Our aim was to detect the different topics discussed by patients on social media and to relate them to functional and symptomatic dimensions assessed in the internationally standardized self-administered questionnaires used in cancer clinical trials (European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire Core 30 [QLQ-C30] and breast cancer module [QLQ-BR23]). First, we applied a classic text mining technique, latent Dirichlet allocation (LDA), to detect the different topics discussed on social media dealing with breast cancer. We applied the LDA model to 2 datasets composed of messages extracted from public Facebook groups and from a public health forum (cancerdusein.org, a French breast cancer forum) with relevant preprocessing. Second, we applied a customized Jaccard coefficient to automatically compute similarity distance between the topics detected with LDA and the questions in the self-administered questionnaires used to study quality of life. Among the 23 topics present in the self-administered questionnaires, 22 matched with the topics discussed by patients on social media. Interestingly, these topics corresponded to 95% (22/23) of the forum and 86% (20/23) of the Facebook group topics. These figures underline that topics related to quality of life are an important concern for patients. However, 5 social media topics had no corresponding topic in the questionnaires, which do not cover all of the patients' concerns. Of these 5 topics, 2 could potentially be used in the questionnaires, and these 2 topics corresponded to a total of 3.10% (523

  4. Large-Scale Topic Detection and Language Model Adaptation

    National Research Council Canada - National Science Library

    Seymore, Kristie

    1997-01-01

    .... We have developed a language model adaptation scheme that takes apiece of text, chooses the most similar topic clusters from a set of over 5000 elemental topics, and uses topic specific language...

  5. Systemic and topical antibiotics for chronic rhinosinusitis.

    Science.gov (United States)

    Head, Karen; Chong, Lee Yee; Piromchai, Patorn; Hopkins, Claire; Philpott, Carl; Schilder, Anne G M; Burton, Martin J

    2016-04-26

    This review is one of six looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and is characterised by inflammation of the lining of the nose and paranasal sinuses leading to nasal blockage, nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Systemic and topical antibiotics are used with the aim of eliminating infection in the short term (and some to reduce inflammation in the long term), in order to normalise nasal mucus and improve symptoms. To assess the effects of systemic and topical antibiotics in people with chronic rhinosinusitis. The Cochrane ENT Information Specialist searched the Cochrane ENT Trials Register; CENTRAL (2015, Issue 8); MEDLINE; EMBASE; ClinicalTrials.gov; ICTRP and additional sources for published and unpublished trials. The date of the search was 29 September 2015. Randomised controlled trials (RCTs) with a follow-up period of at least three months comparing systemic or topical antibiotic treatment to (a) placebo or (b) no treatment or (c) other pharmacological interventions. We used the standard methodological procedures expected by Cochrane. Our primary outcomes were disease-specific health-related quality of life (HRQL), patient-reported disease severity and the commonest adverse event - gastrointestinal disturbance. Secondary outcomes included general HRQL, endoscopic nasal polyp score, computerised tomography (CT) scan score and the adverse events of suspected allergic reaction (rash or skin irritation) and anaphylaxis or other very serious reactions. We used GRADE to assess the quality of the evidence for each outcome; this is indicated in italics. We included five RCTs (293 participants), all of which compared systemic antibiotics with placebo or another pharmacological intervention.The varying study characteristics made comparison difficult. Four studies recruited only adults and one only

  6. Microblog sentiment analysis using social and topic context.

    Science.gov (United States)

    Zou, Xiaomei; Yang, Jing; Zhang, Jianpei

    2018-01-01

    Analyzing massive user-generated microblogs is very crucial in many fields, attracting many researchers to study. However, it is very challenging to process such noisy and short microblogs. Most prior works only use texts to identify sentiment polarity and assume that microblogs are independent and identically distributed, which ignore microblogs are networked data. Therefore, their performance is not usually satisfactory. Inspired by two sociological theories (sentimental consistency and emotional contagion), in this paper, we propose a new method combining social context and topic context to analyze microblog sentiment. In particular, different from previous work using direct user relations, we introduce structure similarity context into social contexts and propose a method to measure structure similarity. In addition, we also introduce topic context to model the semantic relations between microblogs. Social context and topic context are combined by the Laplacian matrix of the graph built by these contexts and Laplacian regularization are added into the microblog sentiment analysis model. Experimental results on two real Twitter datasets demonstrate that our proposed model can outperform baseline methods consistently and significantly.

  7. Hot topics: Signal processing in acoustics

    Science.gov (United States)

    Gaumond, Charles F.

    2005-09-01

    Signal processing in acoustics is a multidisciplinary group of people that work in many areas of acoustics. We have chosen two areas that have shown exciting new applications of signal processing to acoustics or have shown exciting and important results from the use of signal processing. In this session, two hot topics are shown: the use of noiselike acoustic fields to determine sound propagation structure and the use of localization to determine animal behaviors. The first topic shows the application of correlation on geo-acoustic fields to determine the Greens function for propagation through the Earth. These results can then be further used to solve geo-acoustic inverse problems. The first topic also shows the application of correlation using oceanic noise fields to determine the Greens function through the ocean. These results also have utility for oceanic inverse problems. The second topic shows exciting results from the detection, localization, and tracking of marine mammals by two different groups. Results from detection and localization of bullfrogs are shown, too. Each of these studies contributed to the knowledge of animal behavior. [Work supported by ONR.

  8. Common Core: Teaching Optimum Topic Exploration (TOTE)

    Science.gov (United States)

    Karge, Belinda Dunnick; Moore, Roxane Kushner

    2015-01-01

    The Common Core has become a household term and yet many educators do not understand what it means. This article explains the historical perspectives of the Common Core and gives guidance to teachers in application of Teaching Optimum Topic Exploration (TOTE) necessary for full implementation of the Common Core State Standards. An effective…

  9. Expose Mechanical Engineering Students to Biomechanics Topics

    Science.gov (United States)

    Shen, Hui

    2011-01-01

    To adapt the focus of engineering education to emerging new industries and technologies nationwide and in the local area, a biomechanics module has been developed and incorporated into a mechanical engineering technical elective course to expose mechanical engineering students at ONU (Ohio Northern University) to the biomedical engineering topics.…

  10. Selected Topics in International Special Education.

    Science.gov (United States)

    Kelly, Nancy

    2002-01-01

    This article provides information on special education topics on the international front. Information is presented on projects that evaluated early intervention programs, a life-centered career education program in the Philippines, a Peruvian vocational program for individuals with severe disabilities, and special classes for children with…

  11. Topical beta-blockers and mortality

    NARCIS (Netherlands)

    Müskens, Rogier P. H. M.; Wolfs, Roger C. W.; Witteman, Jacqueline C. M.; Hofman, Albert; de Jong, Paulus T. V. M.; Stricker, Bruno H. C.; Jansonius, Nomdo M.

    2008-01-01

    To study the associations between long-term and short-term use of topical beta-blockers and mortality. Prospective population-based cohort study. To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484 incident beta-blocker users and

  12. Topical beta-Blockers and Mortality

    NARCIS (Netherlands)

    Muskens, Rogier P. H. M.; Wolfs, Roger C. W.; Wittenian, Jacqueline C. M.; Hofman, Albert; de Jong, Paulus T. V. M.; Stricker, Bruno H. C.; Jansonius, Nomdo M.

    Purpose: To study the associations between long-term and short-term use of topical beta-blockers and mortality. Design: Prospective population-based cohort study. Participants: To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484

  13. Topics in cement and concrete research

    NARCIS (Netherlands)

    Brouwers, Jos; Russel, M.I.; Basheer, P.A.M.

    2007-01-01

    The present paper addresses several topics in regard to the sustainable design and use of concrete. First, major features concerning the sustainable aspects of the material concrete are summarised. Then the major constituent, from an environmental point of view, cement is discussed in detail,

  14. Topics in mathematical and applied statistics

    NARCIS (Netherlands)

    Pas, van der S.L.

    2017-01-01

    This thesis is composed of papers on four topics: Bayesian theory for the sparse normal means problem, specifically for the horseshoe prior (Chapters 1-3), Bayesian theory for community detection (Chapter 4), nested model selection (Chapter 5), and the application of competing risk methods in the

  15. Do topical antibiotics help corneal epithelial trauma?

    OpenAIRE

    King, J. W.; Brison, R. J.

    1993-01-01

    Topical antibiotics are routinely used in emergency rooms to treat corneal trauma, although no published evidence supports this treatment. In a noncomparative clinical trial, 351 patients with corneal epithelial injuries were treated without antibiotics. The infection rate was 0.7%, suggesting that such injuries can be safely and effectively managed without antibiotics. A comparative clinical trial is neither warranted nor feasible.

  16. Quark-gluon plasma (Selected Topics)

    International Nuclear Information System (INIS)

    Zakharov, V. I.

    2012-01-01

    Introductory lectures to the theory of (strongly interacting) quark-gluon plasma given at the Winter School of Physics of ITEP (Moscow, February 2010). We emphasize theoretical issues highlighted by the discovery of the low viscosity of the plasma. The topics include relativistic hydrodynamics, manifestations of chiral anomaly in hydrodynamics, superfluidity, relativistic superfluid hydrodynamics, effective stringy scalars, holographic models of Yang-Mills theories.

  17. Qualitative content analysis of complementary topical therapies ...

    African Journals Online (AJOL)

    In order to alleviate diabetic foot problems, patients sometimes seek complementary therapies outside the professional context. This paper describes the use of complementary remedies as a topical treatment for diabetic foot ulcers among Jordanians. Qualitative content analysis was used to analyse written responses of 68 ...

  18. Special topics in the theory of piezoelectricity

    CERN Document Server

    Yang, Jiashi

    2009-01-01

    Piezoelectricity has been a steadily growing field, with recent advances made by researchers from applied physics, acoustics, materials science, and engineering. This collective work presents a comprehensive treatment of selected advanced topics in the subject. The book is written for an intermediate graduate level and is intended for researchers, mechanical engineers, and applied mathematicians interested in the advances and new applications in piezoelectricity.

  19. Topical Therapy of Acute Pharyngitis in Children

    Directory of Open Access Journals (Sweden)

    Yu.K. Bolbot

    2015-02-01

    Full Text Available The paper discusses the methods of topical antiinflammatory therapy for acute pharyngitis in children. The analysis of the complex of mechanisms (antiinflammatory, local analgesic ones of Tantum Verde® action and method of its application are provided.

  20. Topical melatonin for treatment of androgenetic alopecia.

    Science.gov (United States)

    Fischer, Tobias W; Trüeb, Ralph M; Hänggi, Gabriella; Innocenti, Marcello; Elsner, Peter

    2012-10-01

    In the search for alternative agents to oral finasteride and topical minoxidil for the treatment of androgenetic alopecia (AGA), melatonin, a potent antioxidant and growth modulator, was identified as a promising candidate based on in vitro and in vivo studies. One pharmacodynamic study on topical application of melatonin and four clinical pre-post studies were performed in patients with androgenetic alopecia or general hair loss and evaluated by standardised questionnaires, TrichoScan, 60-second hair count test and hair pull test. FIVE CLINICAL STUDIES SHOWED POSITIVE EFFECTS OF A TOPICAL MELATONIN SOLUTION IN THE TREATMENT OF AGA IN MEN AND WOMEN WHILE SHOWING GOOD TOLERABILITY: (1) Pharmacodynamics under once-daily topical application in the evening showed no significant influence on endogenous serum melatonin levels. (2) An observational study involving 30 men and women showed a significant reduction in the degree of severity of alopecia after 30 and 90 days (P melatonin solution can be considered as a treatment option in androgenetic alopecia.

  1. Spectral Learning for Supervised Topic Models.

    Science.gov (United States)

    Ren, Yong; Wang, Yining; Zhu, Jun

    2018-03-01

    Supervised topic models simultaneously model the latent topic structure of large collections of documents and a response variable associated with each document. Existing inference methods are based on variational approximation or Monte Carlo sampling, which often suffers from the local minimum defect. Spectral methods have been applied to learn unsupervised topic models, such as latent Dirichlet allocation (LDA), with provable guarantees. This paper investigates the possibility of applying spectral methods to recover the parameters of supervised LDA (sLDA). We first present a two-stage spectral method, which recovers the parameters of LDA followed by a power update method to recover the regression model parameters. Then, we further present a single-phase spectral algorithm to jointly recover the topic distribution matrix as well as the regression weights. Our spectral algorithms are provably correct and computationally efficient. We prove a sample complexity bound for each algorithm and subsequently derive a sufficient condition for the identifiability of sLDA. Thorough experiments on synthetic and real-world datasets verify the theory and demonstrate the practical effectiveness of the spectral algorithms. In fact, our results on a large-scale review rating dataset demonstrate that our single-phase spectral algorithm alone gets comparable or even better performance than state-of-the-art methods, while previous work on spectral methods has rarely reported such promising performance.

  2. Selected topics from classical bacterial genetics.

    Science.gov (United States)

    Raleigh, Elisabeth A; Elbing, Karen; Brent, Roger

    2002-08-01

    Current cloning technology exploits many facts learned from classical bacterial genetics. This unit covers those that are critical to understanding the techniques described in this book. Topics include antibiotics, the LAC operon, the F factor, nonsense suppressors, genetic markers, genotype and phenotype, DNA restriction, modification and methylation and recombination.

  3. Nonsteroidal Topical Immunomodulators in Allergology and Dermatology

    Directory of Open Access Journals (Sweden)

    Marina Jovanović

    2016-01-01

    Full Text Available The purpose of this study was to review currently available literature data concerning pathomechanisms of action, indications, treatment efficacy, as well as side effects of nonsteroidal immunomodulators used in dermatology, primarily for the treatment of allergic dermatoses. MEDLINE search was undertaken using the key words “Topical Immunomodulators, Dermatology and Allergy”. Full articles, and nothing but full articles, were used.

  4. Topic III - Infiltration and Drainage: A section in Joint US Geological Survey, US Nuclear Regulatory Commission workshop on research related to low-level radioactive waste disposal, May 4-6, 1993, National Center, Reston, Virginia; Proceedings (WRI 95-4015)

    Science.gov (United States)

    Prudic, David E.; Gee, Glendon; Stevens, Peter R.; Nicholson, Thomas J.

    1996-01-01

    Infiltration into and drainage from facilities for the disposal of low-level radioactive wastes is considered the major process by which non-volatile contaminants are transported away from the facilities. The session included 10 papers related to the processes of infiltration and drainage, and to the simulation of flow and transport through the unsaturated zone. The first paper, presented by David Stonestrom, was an overview regarding the application of unsaturated flow theory to infiltration and drainage. Stonestrom posed three basic questions, which are:How well do we know the relevant processes affecting flow and transport?How well can we measure the parametric functions used to quantify flow and transport?How do we treat complexities inherent in field settings?The other nine papers presented during the session gave some insight to these questions. Topics included: laboratory measurement of unsaturated hydraulic conductivities at low water contents, by John Nimmo; use of environmental tracers to identify preferential flow through fractured media and to quantify drainage, by Edmund Prych and Edwin Weeks; field experiments to evaluate relevant processes affecting infiltration and drainage, by Brian Andraski, Glendon Gee, and Peter Wierenga; and the use of determinist'c and stochastic models for simulating flow and transport through heterogeneous sediments, by Richard Hills, Lynn Gelhar, and Shlomo Neuman.

  5. A Data-Based Approach to Discovering Multi-Topic Influential Leaders.

    Directory of Open Access Journals (Sweden)

    Xing Tang

    Full Text Available Recently, increasing numbers of users have adopted microblogging services as their main information source. However, most of them find themselves drowning in the millions of posts produced by other users every day. To cope with this, identifying a set of the most influential people is paramount. Moreover, finding a set of related influential users to expand the coverage of one particular topic is required in real world scenarios. Most of the existing algorithms in this area focus on topology-related methods such as PageRank. These methods mine link structures to find the expected influential rank of users. However, because they ignore the interaction data, these methods turn out to be less effective in social networks. In reality, a variety of topics exist within the information diffusing through the network. Because they have different interests, users play different roles in the diffusion of information related to different topics. As a result, distinguishing influential leaders according to different topics is also worthy of research. In this paper, we propose a multi-topic influence diffusion model (MTID based on traces acquired from historic information. We decompose the influential scores of users into two parts: the direct influence determined by information propagation along the link structure and indirect influence that extends beyond the restrictions of direct follower relationships. To model the network from a multi-topical viewpoint, we introduce topic pools, each of which represents a particular topic information source. Then, we extract the topic distributions from the traces of tweets, determining the influence propagation probability and content generation probability. In the network, we adopt multiple ground nodes representing topic pools to connect every user through bidirectional links. Based on this multi-topical view of the network, we further introduce the topic-dependent rank (TD-Rank algorithm to identify the multi-topic

  6. A Data-Based Approach to Discovering Multi-Topic Influential Leaders.

    Science.gov (United States)

    Tang, Xing; Miao, Qiguang; Yu, Shangshang; Quan, Yining

    2016-01-01

    Recently, increasing numbers of users have adopted microblogging services as their main information source. However, most of them find themselves drowning in the millions of posts produced by other users every day. To cope with this, identifying a set of the most influential people is paramount. Moreover, finding a set of related influential users to expand the coverage of one particular topic is required in real world scenarios. Most of the existing algorithms in this area focus on topology-related methods such as PageRank. These methods mine link structures to find the expected influential rank of users. However, because they ignore the interaction data, these methods turn out to be less effective in social networks. In reality, a variety of topics exist within the information diffusing through the network. Because they have different interests, users play different roles in the diffusion of information related to different topics. As a result, distinguishing influential leaders according to different topics is also worthy of research. In this paper, we propose a multi-topic influence diffusion model (MTID) based on traces acquired from historic information. We decompose the influential scores of users into two parts: the direct influence determined by information propagation along the link structure and indirect influence that extends beyond the restrictions of direct follower relationships. To model the network from a multi-topical viewpoint, we introduce topic pools, each of which represents a particular topic information source. Then, we extract the topic distributions from the traces of tweets, determining the influence propagation probability and content generation probability. In the network, we adopt multiple ground nodes representing topic pools to connect every user through bidirectional links. Based on this multi-topical view of the network, we further introduce the topic-dependent rank (TD-Rank) algorithm to identify the multi-topic influential users

  7. EvoRiver: Visual Analysis of Topic Coopetition on Social Media.

    Science.gov (United States)

    Sun, Guodao; Wu, Yingcai; Liu, Shixia; Peng, Tai-Quan; Zhu, Jonathan J H; Liang, Ronghua

    2014-12-01

    Cooperation and competition (jointly called "coopetition") are two modes of interactions among a set of concurrent topics on social media. How do topics cooperate or compete with each other to gain public attention? Which topics tend to cooperate or compete with one another? Who plays the key role in coopetition-related interactions? We answer these intricate questions by proposing a visual analytics system that facilitates the in-depth analysis of topic coopetition on social media. We model the complex interactions among topics as a combination of carry-over, coopetition recruitment, and coopetition distraction effects. This model provides a close functional approximation of the coopetition process by depicting how different groups of influential users (i.e., "topic leaders") affect coopetition. We also design EvoRiver, a time-based visualization, that allows users to explore coopetition-related interactions and to detect dynamically evolving patterns, as well as their major causes. We test our model and demonstrate the usefulness of our system based on two Twitter data sets (social topics data and business topics data).

  8. The role of preventive topical antibiotic treatment prior to intravitreal injection

    Directory of Open Access Journals (Sweden)

    Elena Vladimirovna Ageeva

    2015-06-01

    Full Text Available Treatment of wet age-related macular degeneration (AMD requires frequent intravitreal injections of anti-VEGF agents, sometimes on monthly basis during a long period of time. Endophthalmitis is a rare but extremely severe complication of intravitreal injections. As it has been proven before, the flora from the conjunctival surface is the main source for endophthalmitis. Using Povidone-iodine solution (Betadine10 % Povidone-iodine, EGIS PHARMACEUTICALS is the only way to prevent endophthalmitis. The efficacy of it was proven by numerous studies. No evidence exists that topical antibiotiotics prior and after injections could be effective for prevention of endophthalmitis. Purpose: To study the advisability of topical antibiotic application before intravitreal injection. Materials and methods: Under investigation, there were 25 eyes of 25 patients with wet AMD treated by anti-VEGF intravitreal injections. All patients used topical antibiotics 3 days before injection. Conjunctival culture from injection eye was collected three times: before topical antibiotic use; after topical antibiotic use, and after Betadine 5 % application. Results: The rates of Staphylococcus epidermidis before and after topical antibiotic use were approximately equal. However there was no Staphylococcus epidermidis found after Betadine 5 % application. Conclusion: Our study showed the effectiveness of Betadine 5 % solution in conjunctival flora reduction. Use of topical antibiotics 3 days prior intravitreal injections is not effective. Key words: age-related macular degeneration; endophthalmitis; intravitreal injection; topical antibiotics; endophthalmitis prevention.

  9. Antibacterial drugs in the form of sprays for the topical treatment of pyodermas and dermatoses complicated with a secondary infection

    Directory of Open Access Journals (Sweden)

    YE. V. Matushevskaya

    2014-01-01

    Full Text Available The article covers issues related to the application of topical antibacterial drugs for the treatment of pyodermic skin diseases. The author describes mechanisms of action and advantages of the topical form of antibiotics and GCS for the topical treatment of pyodermas. The article substantiates indications for the administration of topical GCS drugs in a combination with antibacterial drugs. The efficacy and safety of antibacterial and combination topical drugs such as Neomycin, Oxycort and Polcortolon TC in the form sprays for the treatment of pyodermas and complicated forms of chronic dermatosis.

  10. Strategies of persuasion in offers to participate in cancer clinical trials I: Topic placement and topic framing.

    Science.gov (United States)

    Barton, Ellen; Eggly, Susan; Winckles, Andrew; Albrecht, Terrance L

    2014-01-01

    Clinical trials are the gold standard in medical research evaluating new treatments in cancer care; however, in the United States, too few patients enroll in trials, especially patients from minority groups. Offering patients the option of a clinical trial is an ethically-charged communicative event for oncologists. One particularly vexed ethical issue is the use of persuasion in trial offers. Based on a corpus of 22 oncology encounters with Caucasian-American (n = 11) and African-American (n = 11) patients, this discourse analysis describes oncologists' use of two persuasive strategies related to the linguistic structure of trial offers: topic placement and topic framing. Findings are presented in total and by patient race, and discussed in terms of whether these strategies may constitute ethical or unethical persuasion, particularly with respect to the ethical issue of undue influence and the social issue of underrepresentation of minorities in cancer clinical trials.

  11. Honey as a topical treatment for wounds.

    Science.gov (United States)

    Jull, Andrew B; Cullum, Nicky; Dumville, Jo C; Westby, Maggie J; Deshpande, Sohan; Walker, Natalie

    2015-03-06

    Honey is a viscous, supersaturated sugar solution derived from nectar gathered and modified by the honeybee, Apis mellifera. Honey has been used since ancient times as a remedy in wound care. Evidence from animal studies and some trials has suggested that honey may accelerate wound healing. The objective of this review was to assess the effects of honey compared with alternative wound dressings and topical treatments on the of healing of acute (e.g. burns, lacerations) and/or chronic (e.g. venous ulcers) wounds. For this update of the review we searched the Cochrane Wounds Group Specialised Register (searched 15 October 2014); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2014, Issue 9); Ovid MEDLINE (1946 to October Week 1 2014); Ovid MEDLINE (In-Process & Other Non-Indexed Citations 13 October 2014); Ovid EMBASE (1974 to 13 October 2014); and EBSCO CINAHL (1982 to 15 October 2014). Randomised and quasi-randomised trials that evaluated honey as a treatment for any sort of acute or chronic wound were sought. There was no restriction in terms of source, date of publication or language. Wound healing was the primary endpoint. Data from eligible trials were extracted and summarised by one review author, using a data extraction sheet, and independently verified by a second review author. All data have been subsequently checked by two more authors. We identified 26 eligible trials (total of 3011 participants). Three trials evaluated the effects of honey in minor acute wounds, 11 trials evaluated honey in burns, 10 trials recruited people with different chronic wounds including two in people with venous leg ulcers, two trials in people with diabetic foot ulcers and single trials in infected post-operative wounds, pressure injuries, cutaneous Leishmaniasis and Fournier's gangrene. Two trials recruited a mixed population of people with acute and chronic wounds. The quality of the evidence varied between different comparisons and

  12. Non-adherence to topical treatments for actinic keratosis

    Directory of Open Access Journals (Sweden)

    Shergill B

    2013-12-01

    Full Text Available Bav Shergill,1 Simon Zokaie,2 Alison J Carr3 1Department of Dermatology, Brighton and Sussex University Hospitals, Elm Grove, Brighton, UK; 2Leo Pharma, Princes Risborough, 3Hamell, London, UK Background: There is limited information on the patterns of use, adherence rates, and factors that impact adherence with topical treatments for actinic keratosis (AK. Objectives: To establish patterns of use and adherence with topical treatments for AK and to identify treatment-related factors that impact on adherence. Methods: A community-based, cross-sectional study was performed using a standardized questionnaire completed online or via telephone interview. Patients were stratified according to the presence of AK lesions on the scalp and/or other extremities; and presence of scarring resulting from treatment. Results: This study included 305 patients with AK who were currently using a patient-applied topical therapy for AK or had used one within the previous 12 months. In total, 88% (n = 268/305 of patients were either non-adherent, non-persistent or both non-adherent and non-persistent to topical therapy. Duration of treatment was associated with increasing rates of non-adherence (adjusted odds ratio [OR]; for treatment durations greater than 4 weeks, 2.2, P < 0.01: 52% of patients were non-adherent with 3–4 week treatment duration; 69% of patients with 4–8 week treatment duration; and 71% of patients with 6–12 week treatment duration. There were similar increases in non-persistence with increasing treatment duration (adjusted OR; for treatment durations greater than 4 weeks, 2.1, P < 0.05. Conclusion: This study found high rates of non-adherence and non-persistence in patients with AK. Duration of treatment was a significant factor contributing to non-adherence and non-persistence to topical treatments. Patient-applied topical therapies that require less frequent application and have shorter treatment duration may be associated with improved

  13. Topical phenytoin for treating pressure ulcers.

    Science.gov (United States)

    Hao, Xiang Yong; Li, Hong Ling; Su, He; Cai, Hui; Guo, Tian Kang; Liu, Ruifeng; Jiang, Lei; Shen, Yan Fei

    2017-02-22

    Pressure ulcers are common in clinical practice and pose a significant health problem worldwide. Apart from causing suffering to patients, they also result in longer hospital stays and increase the cost of health care. A variety of methods are used for treating pressure ulcers, including pressure relief, patient repositioning, biophysical strategies, nutritional supplementation, debridement, topical negative pressure, and local treatments including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin. Phenytoin is a drug more commonly used in the treatment of epilepsy, but may play an important role in accelerating ulcer healing. To assess the effects of topical phenytoin on the rate of healing of pressure ulcers of any grade, in any care setting. In September 2016, we searched the following electronic databases to identify relevant randomized clinical trials: the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library); Ovid MEDLINE; Ovid Embase; and EBSCO CINAHL Plus. We handsearched conference proceedings from the European Pressure Ulcer Advisory Panel, European Wound Management Association and the Tissue Viability Society for all available years. We searched the references of the retrieved trials to identify further relevant trials. We also searched clinical trials registries to identify ongoing and unpublished studies. There were no restrictions with respect to language, date of publication or study setting. We included all randomized controlled trials (RCTs) addressing the effects (both benefits and harms) of topical phenytoin on the healing of pressure ulcers of any grade compared with placebo or alternative treatments or no therapy, irrespective of blinding, language, and publication status. Two review authors independently selected studies, extracted information on participants, interventions, methods and results and assessed risk of bias using

  14. Topical Nano and Microemulsions for Skin Delivery

    Directory of Open Access Journals (Sweden)

    Christofori M. R. R. Nastiti

    2017-09-01

    Full Text Available Nanosystems such as microemulsions (ME and nanoemulsions (NE offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.

  15. Topics in dual models and extended solutions

    International Nuclear Information System (INIS)

    Roth, R.S.

    1977-01-01

    Two main topics are explored. The first deals with the infinities arising from the one loop planar string diagram of the standard dual model. It is shown that for the number of dimensions d = 25 or 26, these infinities lead to a renormalization of the slope of the Regge trajectories, in addition to a renormalization of the coupling constant. The second topic deals with the propagator for a confined particle (monopole) in a field theory. When summed to all orders, this propagator is altogether free of singularities in the finite momentum plane, and an attempt is made to illustrate this. The Bethe-Salpeter equation is examined and it is shown that ladder diagrams are not sufficient to obtain this result. However, in a nonrelativistic approximation confinement is obtained and all poles disappear

  16. Nanoparticles and nanofibers for topical drug delivery

    Science.gov (United States)

    Goyal, Ritu; Macri, Lauren K.; Kaplan, Hilton M.; Kohn, Joachim

    2016-01-01

    This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the use of nanotechnology, specifically nanoparticles and nanofibers, as drug delivery systems for topical and transdermal applications. This approach employs increased drug concentration in the carrier, in order to increase drug flux into and through the skin. Both nanoparticles and nanofibers can be used to deliver hydrophobic and hydrophilic drugs and are capable of controlled release for a prolonged period of time. The examples presented provide significant evidence that this area of research has—and will continue to have — a profound impact on both clinical outcomes and the development of new products. PMID:26518723

  17. Topics from the theory of numbers

    CERN Document Server

    Grosswald, Emil

    1984-01-01

    Many of the important and creative developments in modern mathematics resulted from attempts to solve questions that originate in number theory. The publication of Emil Grosswald’s classic text presents an illuminating introduction to number theory. Combining the historical developments with the analytical approach, Topics from the Theory of Numbers offers the reader a diverse range of subjects to investigate, including: * divisibility * congruences * the Riemann zeta function * Diophantine equations and Fermat’s conjecture * the theory of partitions Comprehensive in nature, Topics from the Theory of Numbers is an ideal text for advanced undergraduates and graduate students alike. "In my opinion it is excellent. It is carefully written and represents clearly a work of a scholar who loves and understands his subject. One can only wish more authors would take such pains and would be as good and honest expositors as Grosswald." — Marc Kac "This book is designed for use in a first course in number theory at...

  18. Current status of topical antiretroviral chemoprophylaxis.

    Science.gov (United States)

    Van Damme, Lut; Szpir, Michael

    2012-11-01

    Recent studies suggest that the vaginal delivery of antiretroviral (ARV) agents - such as tenofovir, dapivirine and UC781 - may be a promising way to reduce the high rates of HIV infection among women in developing countries. This review examines these developments. The Microbicide Trials Network 003 study, a large phase IIb trial, was unable to show that daily dosing with 1% tenofovir vaginal gel was effective for HIV prevention. Nevertheless, preclinical and early-phase clinical trials suggest that ARV drugs - formulated in vaginal gels, rings, films, tablets and diaphragms - could be effective for HIV chemoprophylaxis. Investigations of topical chemoprophylaxis methods have seen mixed results in the past 12-18 months. Product adherence may prove to be one of the field's greatest challenges. Phase II and III trials continue to explore different dosing strategies for topical products that contain one or more ARV agents.

  19. Sentiment topic mining based on comment tags

    Science.gov (United States)

    Zhang, Daohai; Liu, Xue; Li, Juan; Fan, Mingyue

    2018-03-01

    With the development of e-commerce, various comments based on tags are generated, how to extract valuable information from these comment tags has become an important content of business management decisions. This study takes HUAWEI mobile phone tags as an example using the sentiment analysis and topic LDA mining method. The first step is data preprocessing and classification of comment tag topic mining. And then make the sentiment classification for comment tags. Finally, mine the comments again and analyze the emotional theme distribution under different sentiment classification. The results show that HUAWEI mobile phone has a good user experience in terms of fluency, cost performance, appearance, etc. Meanwhile, it should pay more attention to independent research and development, product design and development. In addition, battery and speed performance should be enhanced.

  20. Readability and quality of wikipedia pages on neurosurgical topics.

    Science.gov (United States)

    Modiri, Omeed; Guha, Daipayan; Alotaibi, Naif M; Ibrahim, George M; Lipsman, Nir; Fallah, Aria

    2018-03-01

    Wikipedia is the largest online encyclopedia with over 40 million articles, and generating 500 million visits per month. The aim of this study is to assess the readability and quality of Wikipedia pages on neurosurgical related topics. We selected the neurosurgical related Wikipedia pages based on the series of online patient information articles that are published by the American Association of Neurological Surgeons (AANS). We assessed readability of Wikipedia pages using five different readability scales (Flesch Reading Ease, Flesch Kincaid Grade Level, Gunning Fog Index, SMOG) Grade level, and Coleman-Liau Index). We used the Center for Disease Control (CDC) Clear Communication Index as well as the DISCERN Instrument to evaluate the quality of each Wikipedia article. We identified a total of fifty-five Wikipedia articles that corresponded with patient information articles published by the AANS. This constitutes 77.46% of the AANS topics. The mean Flesch Kincaid reading ease score for all of the Wikipedia articles we analyzed is 31.10, which indicates that a college-level education is necessary to understand them. In comparison to the readability analysis for the AANS articles, the Wikipedia articles were more difficult to read across every scale. None of the Wikipedia articles meet the CDC criterion for clear communications. Our analyses demonstrated that Wikipedia articles related to neurosurgical topics are associated with higher grade levels for reading and also below the expected levels of clear communications for patients. Collaborative efforts from the neurosurgical community are needed to enhance the readability and quality of Wikipedia pages related to neurosurgery. Copyright © 2018 Elsevier B.V. All rights reserved.

  1. Context updating during sentence comprehension: the effect of aboutness topic.

    Science.gov (United States)

    Burmester, Juliane; Spalek, Katharina; Wartenburger, Isabell

    2014-10-01

    To communicate efficiently, speakers typically link their utterances to the discourse environment and adapt their utterances to the listener's discourse representation. Information structure describes how linguistic information is packaged within a discourse to optimize information transfer. The present study investigates the nature and time course of context integration (i.e., aboutness topic vs. neutral context) on the comprehension of German declarative sentences with either subject-before-object (SO) or object-before-subject (OS) word order using offline comprehensibility judgments and online event-related potentials (ERPs). Comprehensibility judgments revealed that the topic context selectively facilitated comprehension of stories containing OS (i.e., non-canonical) sentences. In the ERPs, the topic context effect was reflected in a less pronounced late positivity at the sentence-initial object. In line with the Syntax-Discourse Model, we argue that these context-induced effects are attributable to reduced processing costs for updating the current discourse model. The results support recent approaches of neurocognitive models of discourse processing. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Topical Day on Biological Effects of Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Baatout, S.; Jacquet, P.

    1997-05-15

    The topical day has been focussed on the potential effects of ionizing radiation on human health. A general overview on molecular and biophysical aspects of radiation, its effects on cells and organisms, and the contribution of radiobiology to radiation protection and risk assessment is given. The genetic effects of radiation and its effects on the developing organism, the effects of radiation on the cell cycle and the mechanisms of radiation induced apoptosis were also discussed.

  3. Topical problems of nuclear law viewed internationally

    International Nuclear Information System (INIS)

    Bischof, W.

    1978-01-01

    The International Nuclear Law Association, on its 3rd Congress Nuclear Inter Jura from October 2-5, 1977 in Italy, dealt with a number of topical problems of nuclear law, in particular aspects concerning agreements in connection with the construction of nuclear facilities, the influence of nuclear energy on the environment and the public acceptance, third party liability, and nuclear insurance, radiation protection law and international judicial problems. (orig.) [de

  4. Topics in cement and concrete research

    OpenAIRE

    Brouwers, Jos; Russel, M.I.; Basheer, P.A.M.

    2007-01-01

    The present paper addresses several topics in regard to the sustainable design and use of concrete. First, major features concerning the sustainable aspects of the material concrete are summarised. Then the major constituent, from an environmental point of view, cement is discussed in detail, particularly the hydration and application of slag cement. The intelligent combining of mineral oxides, which are found in clinker, slag, fly ashes etc., is designated as mineral oxide engineering. It re...

  5. Topical rebamipide improves lid wiper epitheliopathy

    OpenAIRE

    Itakura, Hirotaka; Kashima, Tomoyuki; Itakura, Mariko; Akiyama, Hideo; Kishi, Shoji

    2013-01-01

    Hirotaka Itakura,1,2 Tomoyuki Kashima,2 Mariko Itakura,1 Hideo Akiyama,2 Shoji Kishi2 1Department of Ophthalmology, Maebashi Red Cross Hospital, 2Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, Japan Abstract: Administration of topical rebamipide increases the mucin level of tear film and improves the ocular surface in short break-up time type of dry eye. Lid wiper epitheliopathy (LWE) is a disorder of the marginal conjunctiva of the upper eyelid with dry eye sym...

  6. Topics in theoretical and applied statistics

    CERN Document Server

    Giommi, Andrea

    2016-01-01

    This book highlights the latest research findings from the 46th International Meeting of the Italian Statistical Society (SIS) in Rome, during which both methodological and applied statistical research was discussed. This selection of fully peer-reviewed papers, originally presented at the meeting, addresses a broad range of topics, including the theory of statistical inference; data mining and multivariate statistical analysis; survey methodologies; analysis of social, demographic and health data; and economic statistics and econometrics.

  7. Transport phenomena an introduction to advanced topics

    CERN Document Server

    Glasgow, Larry A

    2010-01-01

    Enables readers to apply transport phenomena principles to solve advanced problems in all areas of engineering and science This book helps readers elevate their understanding of, and their ability to apply, transport phenomena by introducing a broad range of advanced topics as well as analytical and numerical solution techniques. Readers gain the ability to solve complex problems generally not addressed in undergraduate-level courses, including nonlinear, multidimensional transport, and transient molecular and convective transport scenarios. Avoiding rote memorization, the author em

  8. Interviews concerning topical questions in nuclear technology

    International Nuclear Information System (INIS)

    Segatz, U.; Schatz, A.; Stephany, M.; Michaelis, H.

    1978-01-01

    On the occasion of the Nuclex meeting, October 3-7, 1978, Basle/Switzerland, the editorial department of 'Atom und Strom' questioned some leading scientists in nuclear technology on particularly relevant topics. The following subjects were discussed: - How long can we do without nuclear energy, - Modern technology for nuclear power plants, - Nuclear fuel cycle and environment, - Nuclear energy and European Communities, - Nuclear energy and its risks (reflections on incidents). (orig./UA) [de

  9. Topical Day on Biological Effects of Radiation

    International Nuclear Information System (INIS)

    Baatout, S.; Jacquet, P.

    1997-01-01

    The topical day has been focussed on the potential effects of ionizing radiation on human health. A general overview on molecular and biophysical aspects of radiation, its effects on cells and organisms, and the contribution of radiobiology to radiation protection and risk assessment is given. The genetic effects of radiation and its effects on the developing organism, the effects of radiation on the cell cycle and the mechanisms of radiation induced apoptosis were also discussed

  10. Analyzing the field of bioinformatics with the multi-faceted topic modeling technique.

    Science.gov (United States)

    Heo, Go Eun; Kang, Keun Young; Song, Min; Lee, Jeong-Hoon

    2017-05-31

    Bioinformatics is an interdisciplinary field at the intersection of molecular biology and computing technology. To characterize the field as convergent domain, researchers have used bibliometrics, augmented with text-mining techniques for content analysis. In previous studies, Latent Dirichlet Allocation (LDA) was the most representative topic modeling technique for identifying topic structure of subject areas. However, as opposed to revealing the topic structure in relation to metadata such as authors, publication date, and journals, LDA only displays the simple topic structure. In this paper, we adopt the Tang et al.'s Author-Conference-Topic (ACT) model to study the field of bioinformatics from the perspective of keyphrases, authors, and journals. The ACT model is capable of incorporating the paper, author, and conference into the topic distribution simultaneously. To obtain more meaningful results, we use journals and keyphrases instead of conferences and bag-of-words.. For analysis, we use PubMed to collected forty-six bioinformatics journals from the MEDLINE database. We conducted time series topic analysis over four periods from 1996 to 2015 to further examine the interdisciplinary nature of bioinformatics. We analyze the ACT Model results in each period. Additionally, for further integrated analysis, we conduct a time series analysis among the top-ranked keyphrases, journals, and authors according to their frequency. We also examine the patterns in the top journals by simultaneously identifying the topical probability in each period, as well as the top authors and keyphrases. The results indicate that in recent years diversified topics have become more prevalent and convergent topics have become more clearly represented. The results of our analysis implies that overtime the field of bioinformatics becomes more interdisciplinary where there is a steady increase in peripheral fields such as conceptual, mathematical, and system biology. These results are

  11. Familiar communication partners' facilitation of topic management in conversations with individuals with dementia.

    Science.gov (United States)

    Hall, Karinna; Lind, Christopher; Young, Jessica A; Okell, Elise; van Steenbrugge, Willem

    2018-05-01

    Language and memory impairments affect everyday interactions between individuals with dementia and their communication partners. Impaired topic management, which compromises individuals' construction of relevant, meaningful discourse, is commonly reported amongst individuals with dementia. Currently, limited empirical evidence describes the sequential patterns of behaviour comprising topic-management practices in everyday conversation between individuals with dementia and their communication partners. To describe the sequential patterns of behaviour relating to the manifestation of topic-management impairments and facilitative behaviours in everyday interactions between individuals with dementia and their familiar communication partners (FCPs). Three 20-min conversations between individuals with moderate to severe dementia and their FCPs were recorded. Conversation Analysis was used to examine sequences in which topic-management appeared to be impaired. Conversational behaviours that reflected a difficulty in contributing on-topic talk were pervasive in the talk of the three individuals with dementia. FCPs responded to these conversational difficulties by using two categories of facilitative behaviours. The first involved responding to an individual with dementia's explicit repair-initiation by performing repair. In the second category, explicit repair-initiation was absent; instead, the distance of the conversational difficulty from the prior topic-shifting turn mediated the form and outcome of the FCPs' facilitative behaviours. Each category successfully facilitated the individual with dementia to contribute on-topic talk. The findings contribute to a growing understanding of topic-management abilities in everyday interactions involving individuals with dementia. Individuals with dementia took a proactive role in eliciting topic-management support. The FCPs responded with turns that facilitated the individuals with dementia to talk on-topic. Clinically, the

  12. Remifentanil: A help in topical strabismus surgery.

    Science.gov (United States)

    Sánchez-Guillén, I; López, R; Calle, M A; Diez-Lobo, A B

    2017-12-01

    To analyze the analgesic effect of remifentanil, side effects and complications in topical strabismus surgery. To study the results of strabismus surgery with this type of anesthesia. Retrospective descriptive study. We included 39 patients undergoing strabismus surgery with topical anesthesia and analgesia-based sedation with remifentanil. The data of the anesthetic and surgical technique, surgical results and stability of the deviation angle were analyzed. Thirty nine patients (54% women) were included, the average age was 37,4years old. The mean follow-up was 24,5months. The preoperative diagnoses were exotropia (21 patients), esotropia (12), paresis strabismus (4) and Duane's Syndrome (2). 15% patients had preoperative diplopia and 13 had received previous treatments. The dose range of remifentanil used was 0.05 to 0.2μg/kg/min. The side effects presented were 2 cases of vomit and one of bad collaboration during the intraoperative adjustment, one of the patient reported pain and one case of thoracic rigidity was reported. 79% of the patients obtained a good surgical result and 82% reported being satisfied with the results. The reintervention rate was 5%. Analgesia-based sedation with remifentanil is an useful complement to topical strabismus surgery because it reduces pain during surgery and allows the patient to collaborate during intraoperative adjustment due to its pharmacokinetic characteristics. Copyright © 2017 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  13. Corneal neurotoxicity due to topical benzalkonium chloride.

    Science.gov (United States)

    Sarkar, Joy; Chaudhary, Shweta; Namavari, Abed; Ozturk, Okan; Chang, Jin-Hong; Yco, Lisette; Sonawane, Snehal; Khanolkar, Vishakha; Hallak, Joelle; Jain, Sandeep

    2012-04-06

    The aim of this study was to determine and characterize the effect of topical application of benzalkonium chloride (BAK) on corneal nerves in vivo and in vitro. Thy1-YFP+ neurofluorescent mouse eyes were treated topically with vehicle or BAK (0.01% or 0.1%). Wide-field stereofluorescence microscopy was performed to sequentially image the treated corneas in vivo every week for 4 weeks, and changes in stromal nerve fiber density (NFD) and aqueous tear production were determined. Whole-mount immunofluorescence staining of corneas was performed with antibodies to axonopathy marker SMI-32. Western immunoblot analyses were performed on trigeminal ganglion and corneal lysates to determine abundance of proteins associated with neurotoxicity and regeneration. Compartmental culture of trigeminal ganglion neurons was performed in Campenot devices to determine whether BAK affects neurite outgrowth. BAK-treated corneas exhibited significantly reduced NFD and aqueous tear production, and increased inflammatory cell infiltration and fluorescein staining at 1 week (P reduction in neurites occurred after BAK addition to compartmental cultures of dissociated trigeminal ganglion cells. Although both BAK doses (0.0001% and 0.001%) reduced nerve fiber length, the reduction was significantly more with the higher dose (P < 0.001). Topical application of BAK to the eye causes corneal neurotoxicity, inflammation, and reduced aqueous tear production.

  14. Armenian media coverage of science topics

    Science.gov (United States)

    Mkhitaryan, Marie

    2016-12-01

    The article discusses features and issues of Armenian media coverage on scientific topics and provides recommendations on how to promote scientific topics in media. The media is more interested in social or public reaction rather than in scientific information itself. Medical science has a large share of the global media coverage. It is followed by articles about environment, space, technology, physics and other areas. Armenian media mainly tends to focus on a scientific topic if at first sight it contains something revolutionary. Media primarily reviews whether that scientific study can affect the Armenian economy and only then decides to refer to it. Unfortunately, nowadays the perception of science is a little distorted in media. We can often see headlines of news where is mentioned that the scientist has made "an invention". Nowadays it is hard to see the border between a scientist and an inventor. In fact, the technological term "invention" attracts the media by making illusionary sensation and ensuring large audience. The report also addresses the "Gitamard" ("A science-man") special project started in 2016 in Mediamax that tells about scientists and their motivations.

  15. Tracking Multiple Topics for Finding Interesting Articles

    Energy Technology Data Exchange (ETDEWEB)

    Pon, R K; Cardenas, A F; Buttler, D J; Critchlow, T J

    2008-01-03

    We introduce multiple topic tracking (MTT) for iScore to better recommend news articles for users with multiple interests and to address changes in user interests over time. As an extension of the basic Rocchio algorithm, traditional topic detection and tracking, and single-pass clustering, MTT maintains multiple interest profiles to identify interesting articles for a specific user given user-feedback. Focusing on only interesting topics enables iScore to discard useless profiles to address changes in user interests and to achieve a balance between resource consumption and classification accuracy. iScore is able to achieve higher quality results than traditional methods such as the Rocchio algorithm. We identify several operating parameters that work well for MTT. Using the same parameters, we show that MTT alone yields high quality results for recommending interesting articles from several corpora. The inclusion of MTT improves iScore's performance by 25% in recommending news articles from the Yahoo! News RSS feeds and the TREC11 adaptive filter article collection. And through a small user study, we show that iScore can still perform well when only provided with little user feedback.

  16. Topical betamethasone for prevention of radiation dermatitis

    Directory of Open Access Journals (Sweden)

    Omidvari Shapour

    2007-01-01

    Full Text Available Background: Although acute radiation dermatitis (ARD is a common side-effect of radiotherapy (RT, currently there is no general consensus about its prevention or treatment of choice. Aims: The purpose of this study was to investigate whether prophylactic use of topical betamethasone 0.1% can prevent ARD caused by chest wall irradiation. Methods: Fifty-one patients who underwent modified radical mastectomy for breast cancer and were going to receive RT, were randomly assigned to receive topical betamethasone 0.1%, petrolatum or none during RT. The frequency and severity of ARD (measured using Radiation Therapy Oncology Group acute radiation morbidity scoring criteria were recorded at the end of each week during RT and two weeks after its completion. Clinical outcomes were analyzed by relevant statistical methods. Results: All patients developed some degree of ARD, the frequency and severity of which increased with time and reached the maximum at the end of the seventh week for all groups. Patients receiving betamethasone had less severe ARD than the other two groups throughout the course of the study, but this difference was significant only at the end of the third week (p =0.027. No significant difference was observed between the petrolatum and control arms. Conclusion: Prophylactic and ongoing use of topical betamethasone 0.1% during chest wall RT for breast cancer delays occurrence of ARD but does not prevent it. Petrolatum has no effect on the prevention of ARD in these patients.

  17. Topical betamethasone for prevention of radiation dermatitis.

    Science.gov (United States)

    Omidvari, Shapour; Saboori, Hojjatollah; Mohammadianpanah, Mohammad; Mosalaei, Ahmad; Ahmadloo, Niloofar; Mosleh-Shirazi, Mohammad Amin; Jowkar, Farideh; Namaz, Soha

    2007-01-01

    Although acute radiation dermatitis (ARD) is a common side-effect of radiotherapy (RT), currently there is no general consensus about its prevention or treatment of choice. The purpose of this study was to investigate whether prophylactic use of topical betamethasone 0.1% can prevent ARD caused by chest wall irradiation. Fifty-one patients who underwent modified radical mastectomy for breast cancer and were going to receive RT, were randomly assigned to receive topical betamethasone 0.1%, petrolatum or none during RT. The frequency and severity of ARD (measured using Radiation Therapy Oncology Group acute radiation morbidity scoring criteria) were recorded at the end of each week during RT and two weeks after its completion. Clinical outcomes were analyzed by relevant statistical methods. All patients developed some degree of ARD, the frequency and severity of which increased with time and reached the maximum at the end of the seventh week for all groups. Patients receiving betamethasone had less severe ARD than the other two groups throughout the course of the study, but this difference was significant only at the end of the third week (p = 0.027). No significant difference was observed between the petrolatum and control arms. Prophylactic and ongoing use of topical betamethasone 0.1% during chest wall RT for breast cancer delays occurrence of ARD but does not prevent it. Petrolatum has no effect on the prevention of ARD in these patients.

  18. Increasing topical anesthetic efficacy with microneedle application.

    Science.gov (United States)

    Buhsem, Ömer; Aksoy, Alper; Kececi, Yavuz; Sir, Emin; Güngör, Melike

    2016-10-01

    Since topical anesthetics alone seldom provide adequate analgesia for laser resurfacing procedures, injectable forms of anesthesia are often required. However, their application is uncomfortable for the patient. In this study, it is investigated whether microneedle application would enhance the efficacy of topical anesthetics. Forty-seven patients participated in the study. Topical anesthetic agent EMLA was applied to the whole face of the patients. Microneedle treatment was applied to one side of the face with a roller-type device. Whole-face carbon dioxide laser resurfacing therapy was carried out then. The pain that patients experienced was assessed by using visual analog scale (VAS) method. VAS scores of two sides of the face were compared by using Wilcoxon signed-rank test. The mean of VAS score of the microneedle treated side was 2.1 ± 1.1 while that of the untreated side was 5.9 ± 0.9 and this difference was statistically significant (Wilcoxon signed-rank test, the Z-value is - 5.9683 and the p-value is < 0.001). This study revealed that microneedle application, with a roller-type device, is a safe and easy procedure in providing sufficient anesthesia for facial laser resurfacing without the need for supplementary nerve blocks or injections.

  19. Efficacy and safety of topical tranexamic acid in knee arthroplasty.

    Science.gov (United States)

    López-Hualda, Álvaro; Dauder-Gallego, Cristina; Ferreño-Márquez, David; Martínez-Martín, Javier

    2018-02-26

    Tranexamic acid (TXA) is commonly used to control postoperative blood loss in total knee arthroplasty. In order to avoid adverse effects associated with intravenous administration, topical use has been proposed as an alternative. Our aim was to evaluate the efficacy and safety of topical TXA in total knee arthroplasty. A total of 90 patients scheduled for unilateral total knee arthroplasty were included in a prospective randomised study. All surgeries were performed under spinal anaesthesia, tourniquet and the same postoperative protocol. Patients were allocated to one of the 3 groups according to the application of TXA: group A (n=30) 1g of topical TXA; group B (n=30) 1g of TXA intravenous and in group C or the control group (n=30) no drug was administrated. Parameters related to blood loss and drain outputs were compared between the 3 groups. The results revealed that post-operative decrease in haemoglobin level was significantly lower in group A (1.95g/dL) than group B (2.25g/dL) and group C (2.96g/dL), P<.01. Total postoperative blood loss was lower in group A (195mL) than group B (466mL) and group C (718mL), P<.01. There was no significant difference in complications and allogenic blood transfusion rate between the 3 groups. According to the results, topical application of 1g TXA significantly reduced blood loss in patients undergoing total knee arthroplasty more than intravenous or no administration of TXA. Copyright © 2018 Elsevier España, S.L.U. All rights reserved.

  20. Efficacy of adding topical simvastatin to topical calcipotriol on improvement of cutaneous plaque psoriasis

    Directory of Open Access Journals (Sweden)

    Fariba Iraji

    2014-01-01

    Conclusion: This study indicates that topical simvastatin is not associated with significant impacts in the treatment of psoriasis as compared to oral form. This study indicates that psoriasis is a systemic disorder with variable skin manifestations.