Systemic Problems: A perspective on stem cell aging and rejuvenation.

Science.gov (United States)

Conboy, Irina M; Conboy, Michael J; Rebo, Justin

2015-10-01

This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.

Characterization of photorespiration and photosynthesis in soybean cotyledons during seedling development, cotyledon senescence and rejuvenation

International Nuclear Information System (INIS)

Marek, L.F.

1988-01-01

We measured light and dark carbon dioxide exchange rates (CER) in germinating, presenescent, and senescing soybean cotyledons and in cotyledons rejuvenated by epicotyl removal on different days after planting. In other aspects of cotyledon physiology, we observed significant differences between rejuvenated and presenescent soybean cotyledons. Rejuvenated cotyledons accumulated chlorophyll to levels greater than the maximal amount measured in presenescent cotyledons. A second difference was the observation that during rejuvenation, the post-illumination outburst of CO 2 (the PIB), a qualitative indication of photorespiration, appeared to recover more slowly than light CER when compared with presenescent but equivalent light CERs. To investigate the relationship between the PIB and light CER, we labelled cotyledons with 14 CO 2 during photosynthesis. We measured the amount of ribulose-1,5-bisphosphate carboxylase oxygenase (RubisCO) in the cotyledons by rocket immunoelectrophoresis

An introduction to application of Platelet Rich Plasma (PRP in skin rejuvenation

Directory of Open Access Journals (Sweden)

Mahnaz Banihashemi

2014-04-01

Full Text Available Platelet-rich plasma (PRP is an autologous concentration of human platelets contained in a small volume of plasma characterized by haemostatic and tissue repairing effects. Tissue repairing effects and being enriched by various kind of growth factors, has made them the focus of attention for different procedures. PRP has been effective in bony defects, wound healing and recently for aesthetic procedures in plastic surgery. The purpose of this review is to evaluate and summarize the applications of PRP in the dermatology literature, with particular focus on rejuvenizaton process, advances and limitations of current PRP therapies. We studied literature related to PRP therapy, these include regeneration of soft tissue, skin aging mechanisms, as well as wound healing. Some studies have shown promising results, with favorable outcomes about PRP clinical application for skin rejuvenization. This article summarizes our current understanding regarding photoaging process and the role of PRP in the skin rejuvenization process. PRP has been shown to be useful in skin rejuvenization. Further studies are needed to elucidate both basic and clinical aspects of PRP therapies. In particular, platelet preparation methods, different application methods, platelet mechanism of action in rejuvenation field, interactions with the skin components, long-term efficacy and safety are necessary to be determined.

Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

Science.gov (United States)

Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm, Martin C., Jr.; Austen, William G., Jr.; Yarmush, Martin L.

2015-05-01

Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases.

Minimally invasive facial rejuvenation endolaser mid-face lift.

Science.gov (United States)

Badin, A Z; Casagrande, C; Roberts, T; Saltz, R; Moraes, L M; Santiago, M; Chiaratti, M G

2001-01-01

Endolaser mid-face lift was performed on patients in a multi-center study over a 36-month period (Feb. 1998 to Feb. 2001). It permits significant facial rejuvenation through small incisions. This technique achieves aesthetic results and wider rejuvenation while being less traumatic and creating minimal morbidity. Combined with other procedures, it rejuvenates the face by three strategic methods: soft tissue suspension, reversal of photo aging, and correction of the depletion of volume. To achieve this triple result, the mid-face lift is performed by endoscopic approach, and in every case is combined with the endoscopic lift of the frontal area. Laser resurfacing was used to reverse skin photo damage. The Ultrapulse CO2 laser and/or the Ultrafine Erbium YAG(Coherent, Inc, Palo Alto, CA) were used. The third combined procedure was the introduction of fat graft to compensate the atrophy/ptosis of fat and the depletion of bone mass (other filling materials besides fat may be used, depending on the preference of the surgeon). Our method of fixation using the Casagrande Needle (an evolution of Reverdin Needle) makes the mechanical purchase on the tissues to be suspended much easier, permitting the intra-oral and/or infra-orbital incisions to be eliminated. The present study of the technical evolution of the endolaser mid-face lift method allows us to conclude that a very satisfactory outcome has been reached, offering patients a minimally invasive procedure, which can be performed under local anesthesia, with low morbidity, imperceptible incisions, and an excellent long-term result.

Rejuvenating Effects of Facial Hydrofilling using Restylane Vital

Directory of Open Access Journals (Sweden)

Bong Moo Lee

2015-05-01

Full Text Available BackgroundMorphological changes that accompany aging, such as wrinkles and skin laxity, are particularly prominent on facial skin. Recently, facial rejuvenation using the hydrofilling effect of hyaluronic acid (HA filler has been employed for improvement of skin texture. In this study, we studied rejuvenating effects of stabilized HA (Restylane Vital through direct intradermal injections.MethodsA total of 30 female patients underwent a series of procedures on face, including three sessions at intervals of four weeks. A total of 2 mL of Restylane Vital was injected along the whole face using an automatic injector. Improvement of skin surface roughness, elasticity, brightness, moisture, and fine wrinkles was evaluated. Patient satisfaction was evaluated, and pictures of patients were taken at each visit and 6 months after last treatment session. Scoring for each patient was performed by three doctors according in five subjects. Moisture, oil and elasticity were measured before the procedure and before the last treatment in 10 patients.ResultsThe majority of patients (77% were satisfied with the therapeutic outcomes. Approximately 66% of patients responded that the effects of this procedure persisted for longer than four months, and the majority of patients (77% wanted to undergo this procedure again and would recommend this procedure to acquaintances. Regarding doctors' evaluation, scores for improvement of skin surface roughness, elasticity, and brightness were significantly higher than those for improvement of moisture and fine wrinkle.ConclusionsIntradermal injection of HA can have a rejuvenating effect on dry and tired facial skin, especially in improvement of skin surface roughness.

Periorbital area rejuvenation using carbon dioxide therapy.

Science.gov (United States)

Paolo, Fioramonti; Nefer, Fallico; Paola, Parisi; Nicolò, Scuderi

2012-09-01

Different conservative and surgical approaches are used for periorbital region rejuvenation, but none of them is effective in the treatment of the medial third of the lower eyelid. The present study is designed to assess the effectiveness of carboxytherapy in the treatment of wrinkles on the median and medial region of the lower eyelid and dark circles around the eyes. From January 2008 to December 2010, 90 patients with moderate to severe periorbital wrinkles and/or dark circles underwent subcutaneous injections of CO(2) once a week for 7 weeks. Patients were assessed before and 2 months after the treatment through photographic documentation and the compilation of visual analog scales. At the end of the study period, patients reported a reduction of facial fine lines and wrinkles as well as a decrease in periorbital hyperpigmentation. A few side effects were observed but they were all transient and did not require discontinuation of treatment. Carbon dioxide therapy results as an effective noninvasive modality for the rejuvenation of the periorbital area. © 2012 Wiley Periodicals, Inc.

Ziziphus mauritiana leaf extract emulsion for skin rejuvenation ...

African Journals Online (AJOL)

During this period, stability parameters, including liquefaction, phase separation, color, electrical conductivity, centrifugation and pH were monitored at specified time intervals. Skin rejuvenation was evaluated using 13 healthy human volunteers over a period of 8 weeks. During this period, various skin parameters such as ...

Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

Science.gov (United States)

Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm Jr., Martin C.; Austen Jr., William G.; Yarmush, Martin L.

2015-01-01

Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases. PMID:25965851

Aging, rejuvenation and memory phenomena in spin glasses

Indian Academy of Sciences (India)

Spin glass; relaxation; aging; rejuvenation; memory. PACS Nos 75.10. .... the application of finite excitations, the long time needed to cool the sample down ..... wait at T − ∆T during t2 = 9000 s and finally re-heated to T for another short time t3 ...

Effect of a Facial Muscle Exercise Device on Facial Rejuvenation.

Science.gov (United States)

Hwang, Ui-Jae; Kwon, Oh-Yun; Jung, Sung-Hoon; Ahn, Sun-Hee; Gwak, Gyeong-Tae

2018-01-20

The efficacy of facial muscle exercises (FMEs) for facial rejuvenation is controversial. In the majority of previous studies, nonquantitative assessment tools were used to assess the benefits of FMEs. This study examined the effectiveness of FMEs using a Pao (MTG, Nagoya, Japan) device to quantify facial rejuvenation. Fifty females were asked to perform FMEs using a Pao device for 30 seconds twice a day for 8 weeks. Facial muscle thickness and cross-sectional area were measured sonographically. Facial surface distance, surface area, and volumes were determined using a laser scanning system before and after FME. Facial muscle thickness, cross-sectional area, midfacial surface distances, jawline surface distance, and lower facial surface area and volume were compared bilaterally before and after FME using a paired Student t test. The cross-sectional areas of the zygomaticus major and digastric muscles increased significantly (right: P jawline surface distances (right: P = 0.004, left: P = 0.003) decreased significantly after FME using the Pao device. The lower facial surface areas (right: P = 0.005, left: P = 0.006) and volumes (right: P = 0.001, left: P = 0.002) were also significantly reduced after FME using the Pao device. FME using the Pao device can increase facial muscle thickness and cross-sectional area, thus contributing to facial rejuvenation. © 2018 The American Society for Aesthetic Plastic Surgery, Inc.

Young Blood Rejuvenates Old Bodies: A Call for Reflection when Moving from Mice to Men.

Science.gov (United States)

Hofmann, Bjørn

2018-01-01

Connecting the circulatory system of old and young mice (parabiosis) is documented to have rejuvenating effects on cells, tissues, organs, and functions. A wide range of benefits are envisioned. Blood-based rejuvenation can come to totally change population health and aging. The first blood rejuvenation studies on humans with Alzheimer's disease have started. It puts blood at the center of therapy and revitalizes the historical line of humoral pathology from Hippocrates and Harvey, creating a new type of 'bloodletting.' However, moving from mice to men requires careful consideration. Parabiosis actualizes well-known ethical challenges, such as just distribution of health care, avoiding disparities, and providing equal access to health care resources, as well as issues of human enhancement. However, it also poses new problems. Using internal substances in some persons as means to rejuvenate others calls for ethical reflection. New type of 'blood bonds' may result from the continuous demand for specific types of blood. Even if rejuvenating substances from blood may be artificially and cheaply produced and justly distributed, problems arise: survival may have to be balanced against reproduction, as reproductive age increases. Eternal youth and endless bliss have always been vital human dreams. Although parabiosis may bring us closer to the fountain of youth than ever, it is still too early to provide full-fledged assessments of its implications or to foresee how it will change health, aging, medicine, and society. However, in order to bring our reflective abilities on par with our technical skills, we need to start reflection now.

Micropunch blepharopeeling versus blepharoplasty; what is the best procedure for upper eyelid rejuvenation?

Science.gov (United States)

Asilian, Ali; Bafandeh, Behzad; Shahmoradi, Zabihollah; Faghihi, Gita; Bostakian, Anis; Mozafarpoor, Samaneh; Hosseini, Sayed Mohsen

2018-05-17

Periocular rejuvenation is the most common aesthetic plastic surgery. The aim of this study was to determine effects of micropunch blepharopeeling (MBP) approach vs blepharoplasty (BP) in periocular rejuvenation. This is a clinical trial study on 22 patients who underwent periorbital rejuvenation referred to University Skin Clinics. Patients were randomly divided into two groups of blepharoplasty or micropunch blepharopeeling. After procedure, all patients were followed in 2 weeks and 2 months and were asked about complications. Patients' satisfaction was scored based on 5-grade scale. Physician satisfaction was assessed based on patients' photographs taken before and 2 months after surgery based on 4-grade scale. The mean age of group MBP was 48.45 ± 7.71 and group BP was 45.45 ± 7.20 (P-value = .36) and Fitzpatrick skin type was not significantly different. Scar was significantly different between groups that 4 (36.4%) patients of BP complained from scars, while none of MBP had significant scar (P-value = .04). Patients were statistically more satisfied with MBP in terms of symmetry, pain, and scar (P-value = .048, .040, and<.001, respectively). Also, MBP was significantly more satisfying for physicians in terms of symmetry and scar (P-value = .047 and <.001, respectively). Micropunch blepharopeeling can be considered as an acceptable procedure of upper eyelid rejuvenation mentioned by patients and physicians. Micropunch blepharopeeling causes fewer scars, better symmetry, and less pain. © 2018 Wiley Periodicals, Inc.

[Botulinum toxin: An important complement for facial rejuvenation surgery].

Science.gov (United States)

Le Louarn, C

2017-10-01

The improved understanding of the functional anatomy of the face and of the action of the botulinum toxin A leads us to determine a new injection procedure which consequently decreases the risk of eyebrow and eyelid ptosis and increases the toxin's injection possibilities and efficiencies. With less units of toxin, the technique herein described proposes to be more efficient on more muscles: variable toxin injections concentration adapted to each injected muscle are used. Thanks to a new procedure in the upper face, toxin A injection can be quite close to an endoscopic surgical action. In addition, interesting results are achievable to rejuvenate the lateral canthus with injection on the upper lateral tarsus, to rejuvenate the nose with injection at the alar base, the jawline and the neck region. Lastly, a smoothing effect on the skin (meso botox) is obtained by the anticholinergic action of the toxin A on the dermal receptors. Copyright © 2017. Published by Elsevier Masson SAS.

Months between rejuvenation and volcanic eruption at Yellowstone caldera, Wyoming

Science.gov (United States)

Till, Christy B.; Vazquez, Jorge A.; Boyce, Jeremy W

2015-01-01

Rejuvenation of previously intruded silicic magma is an important process leading to effusive rhyolite, which is the most common product of volcanism at calderas with protracted histories of eruption and unrest such as Yellowstone, Long Valley, and Valles, USA. Although orders of magnitude smaller in volume than rare caldera-forming super-eruptions, these relatively frequent effusions of rhyolite are comparable to the largest eruptions of the 20th century and pose a considerable volcanic hazard. However, the physical pathway from rejuvenation to eruption of silicic magma is unclear particularly because the time between reheating of a subvolcanic intrusion and eruption is poorly quantified. This study uses geospeedometry of trace element profiles with nanometer resolution in sanidine crystals to reveal that Yellowstone’s most recent volcanic cycle began when remobilization of a near- or sub-solidus silicic magma occurred less than 10 months prior to eruption, following a 220,000 year period of volcanic repose. Our results reveal a geologically rapid timescale for rejuvenation and effusion of ~3 km3 of high-silica rhyolite lava even after protracted cooling of the subvolcanic system, which is consistent with recent physical modeling that predict a timescale of several years or less. Future renewal of rhyolitic volcanism at Yellowstone is likely to require an energetic intrusion of mafic or silicic magma into the shallow subvolcanic reservoir and could rapidly generate an eruptible rhyolite on timescales similar to those documented here.

Patient-specific rhytidectomy: finding the angle of maximal rejuvenation.

Science.gov (United States)

Jacono, Andrew A; Ransom, Evan R

2012-09-01

Rhytidectomy is fundamentally an operation of tissue release and resuspension, although the manner and direction of suspension are subject to perpetual debate. The authors describe a method for identifying the angle of maximal rejuvenation during rhytidectomy and quantify the resulting angle and its relationship to patient age. Patients were prospectively enrolled; demographic data, history, and operative details were recorded. Rhytidectomies were performed by the senior author (AAJ). After complete elevation, the face-lift flap was rotated in a medially-based arc (0-90°) while attention was given to the submental area, jawline, and midface. The angle of maximal rejuvenation for each hemiface was identified as described, and the flap was resuspended. During redraping, measurements of vertical and horizontal skin excess were recorded in situ. The resulting angle of lift was then calculated for each hemiface using trigonometry. Symmetry between sides was determined, and the effect of patient age on this angle was assessed. Three hundred hemifaces were operated (147 women; 3 men). Mean age was 60 years (range, 37-80 years). Mean resulting angle for the cohort was 60° from horizontal (range, 46-77°). This was inversely correlated with patient age (r = -.3). Younger patients (<50 years, 64°) had a significantly more vertical angle than older patients (≥70 years, 56°; P < .0002). No significant intersubject difference was found between hemifaces (P = .53). The authors present a method for identifying the angle of maximal rejuvenation during rhytidectomy. This angle was more superior than posterior in all cases and is intimately related to patient age. Lasting results demand a detailed anatomical understanding and strict attention to the direction and degree of laxity.

Rejuvenation of service exposed ammonia cracker tubes of cast Alloy 625 and their re-use

Energy Technology Data Exchange (ETDEWEB)

Singh, J.B., E-mail: jbsingh@barc.gov.in [Mechanical Metallurgy Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Verma, A. [Mechanical Metallurgy Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Jaiswal, D.M.; Kumar, N.; Patel, R.D. [Heavy Water Board, Department of Atomic Energy, Anushakti Nagar, Mumbai 400094 (India); Chakravartty, J.K. [Mechanical Metallurgy Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

2015-09-17

This study is an extension of a previous study undertaken to rejuvenate ammonia cracker tubes of Alloy 625 alloy that have been service exposed in heavy water plants for their full service life of 100,000 h. The service exposure caused significant microstructural modifications and deterioration in mechanical properties, and a solution annealing treatment of 2 h at 1160 °C rejuvenated all properties similar to those of the virgin alloy. The present study reports the evolution of microstructure and mechanical properties of a full service exposed centrifugally cast Alloy 625 tube that was put into service again for 55,000 h after receiving a rejuvenation treatment. During the second service, microstructural modifications, increase in strength and loss of ductility were on the lines of the work reported earlier. However, it was encouraging to observe that degraded properties after the second service life remained within the bounds of those of virgin and full service exposed tubes. The good performance of the rejuvenated tube during the second service life has been attributed to good control of operation parameters that limited the precipitation of grain boundary carbides during the first service life, which otherwise would have had a direct bearing on premature failure of tubes during their second service life.

A Software Rejuvenation Framework for Distributed Computing

Science.gov (United States)

Chau, Savio

2009-01-01

A performability-oriented conceptual framework for software rejuvenation has been constructed as a means of increasing levels of reliability and performance in distributed stateful computing. As used here, performability-oriented signifies that the construction of the framework is guided by the concept of analyzing the ability of a given computing system to deliver services with gracefully degradable performance. The framework is especially intended to support applications that involve stateful replicas of server computers.

Energy-Based Facial Rejuvenation: Advances in Diagnosis and Treatment.

Science.gov (United States)

Britt, Christopher J; Marcus, Benjamin

2017-01-01

The market for nonsurgical, energy-based facial rejuvenation techniques has increased exponentially since lasers were first used for skin rejuvenation in 1983. Advances in this area have led to a wide range of products that require the modern facial plastic surgeon to have a large repertoire of knowledge. To serve as a guide for current trends in the development of technology, applications, and outcomes of laser and laser-related technology over the past 5 years. We performed a review of PubMed from January 1, 2011, to March 1, 2016, and focused on randomized clinical trials, meta-analyses, systematic reviews, and clinical practice guidelines including case control, case studies and case reports when necessary, and included 14 articles we deemed landmark articles before 2011. Three broad categories of technology are leading non-energy-based rejuvenation technology: lasers, light therapy, and non-laser-based thermal tightening devices. Laser light therapy has continued to diversify with the use of ablative and nonablative resurfacing technologies, fractionated lasers, and their combined use. Light therapy has developed for use in combination with other technologies or stand alone. Finally, thermally based nonlaser skin-tightening devices, such as radiofrequency (RF) and intense focused ultrasonography (IFUS), are evolving technologies that have changed rapidly over the past 5 years. Improvements in safety and efficacy for energy-based treatment have expanded the patient base considering these therapies viable options. With a wide variety of options, the modern facial plastic surgeon can have a frank discussion with the patient regarding nonsurgical techniques that were never before available. Many of these patients can now derive benefit from treatments requiring significantly less downtime than before while the clinician can augment the treatment to maximize benefit to fit the patient's time schedule.

Submarine Rejuvenated-Stage Lavas Offshore Molokai, Oahu, Kauai, and Niihau, Hawaii

Science.gov (United States)

Clague, D. A.; Cousens, B. L.; Davis, A. S.; Dixon, J. E.; Hon, K.; Moore, J. G.; Reynolds, J. R.

2003-12-01

Rejuvenated-stage lavas from the Hawaiian Islands form many distinctive landmarks, such as Diamond Head. They have been relatively well studied due to their primitive, strongly alkaline compositions (alkalic basalt, basanite, nephelinite, melilitite, phonolite). More recently, compositionally similar lavas have been mapped and sampled on the deep seafloor around the islands. Rejuvenated-stage cones also occur on the submarine flanks of the islands. A Pisces V submersible dive collected samples from the only submarine cone on the north slope of East Molokai. The alkalic basalt to basanite composition lava is similar to the subaerial Kalaupapa basalt (Clague and Moore, 2003). MBARI Tiburon ROV dives recovered nephelinite from a lone steep cone on the northeast slope of Oahu, alkalic basalt from two shallow steep cones just west of the Koko Rift, and alkalic basalt from the submarine flank of Diamond Head on Oahu's south flank. These lavas are generally similar to subaerial Honolulu Volcanics, although the isotopic data extend to higher Sr isotopic values. Other MBARI Tiburon ROV dives recovered alkalic basalt and basanite from 8 separate steep cones on the south flank of Kauai. Once again, these lavas are chemically similar to those from the subaerial Koloa Volcanics. Samples from one of these cones contained common xenoliths of upper mantle lherzolite and harzburgite. Seven MBARI Tiburon ROV dives on the northwest flank of Niihau sampled 6 flat-topped cones and 5 pointed cones. The lavas from the flat-topped cones are alkalic basalt similar to rejuvenated Kiekie Basalt on Niihau Island whereas the lavas from the pointed cones are basanite, hawaiite, and tephrophonolite that are chemically distinct from the Kiekie Basalt, but similar to rejuvenated-stage lavas on Kauai and Oahu. Volcaniclastic deposits were observed and sampled at many of the sites offshore Niihau, Kauai, and Oahu, as well as the North Arch. Breadcrust and spindle bombs and spatter were found

Neuro-rejuvenation for neuronal function

Institute of Scientific and Technical Information of China (English)

Yuan Liu; Richard K. Lee

2016-01-01

Neurodegenerative eye diseases, such as glaucoma, cause irreversible vision loss in millions of patients worldwide, creating serious medical, economic and social issues. Like other mammalian central nervous system tracts, optic nerve intrinsically lacks the capacity for axonal growth and its surrounding environment is also non-permissive to regeneration. Any axonal damage also triggers a vicious cycle of retinal ganglion cell (RGC) death. Exploring methods that can enhance RGCs survival and promote axonal regeneration will not only enable vision restoration for millions of patients, but also shed light on the treatment of other neurodegenerative diseases. In this review article, we will go through three current approaches to cure neu-rodegenerative eye diseases, including cell based therapy, neuro-regeneration and neuro-rejuvenation.

Variation in effective pollination rates in relation to the spatial and temporal distribution of pollen release in rejuvenated perennial ryegrass

NARCIS (Netherlands)

Treuren, van R.; Goossens, P.J.; Sevcikova, M.

2006-01-01

Genebank accessions stored as seed populations require periodic rejuvenation in order to maintain sufficient numbers of viable seeds. During rejuvenation the genetic composition of accessions may be altered for a variety of reasons, of which variation in pollination rates between plants is the least

Development of Facial Rejuvenation Procedures: Thirty Years of Clinical Experience with Face Lifts

Directory of Open Access Journals (Sweden)

Byung Jun Kim

2015-09-01

Full Text Available Facial rejuvenation procedures can be roughly divided into face lift surgery and nonoperative, less invasive procedures, such as fat grafts, fillers, botulinum toxin injections, thread lifts, or laserbrasion. Face lift surgery or rhytidectomy is the procedure most directly associated with rejuvenation, due to its fundamental ability to restore the anatomical changes caused by aging. Various methods of face lift surgery have been developed over the last hundred years, thanks to advances in the understanding of facial anatomy and the mechanisms of aging, as well as the dedication of innovative surgeons. However, no generally applicable standard method exists, because the condition of each patient is different, and each operative method has advantages and disadvantages. Specific characteristics of the skin of Asians and their skeletal anatomy should be considered when determining the operative method to be used on Asian patients. Plastic surgeons should improve their ability to analyze the original aesthetic properties and problem areas of each patient, drawing on scientific knowledge about the aging process, and they should develop the skills necessary to perform various rejuvenative techniques. In the present article, we reviewed various face lift procedures and the current methods of modified double plane face lift, based on our clinical experience of over 30 years.

Effects of asphalt rejuvenator on thermal and mechanical properties on oxidized hot mixed asphalt pavements

Science.gov (United States)

Farace, Nicholas A.; Buttlar, William G.; Reis, Henrique

2016-04-01

The utilization of asphalt rejuvenator, and its effectiveness for restoring thermal and mechanical properties was investigated via Disk-shaped Compact Tension (DC(T)) and acoustic emission (AE) testing for determining mechanical properties and embrittlement temperatures of the mixtures. During the DC(T) testing the fracture energies and peak loads were used to measure the resistance of the rejuvenated asphalt to low temperature cracking. The AE testing monitored the acoustic emission activity while the specimens were cooled from room temperature to -40 °C to estimate the temperature at which thermal cracking began (i.e. the embrittlement temperature). First, a baseline response was obtained by obtaining the mechanical and thermal response of virgin HMA samples and HMA samples that had been exposed to oxidative aging for 36 hours at 135°C. The results showed the virgin samples had much higher peak loads and fracture energies than the 36 hours aged samples. Acoustic Emission showed similar results with the virgin samples having embrittlement temperatures 10 °C cooler than the 36 hours aged specimens. Then, overaged for 36 hours specimens were treated different amounts of rejuvenator (10%, 15%, and 20% by weight of binder content) and left to dwell for increased amount of time periods varying from one to eight weeks. It was observed that the AE results showed an improvement of embrittlement temperature with increasing with the dwell times. The 8 weeks specimens had cooler embrittlement temperatures than the virgin specimens. Finally, the low temperature effects on fracture energy and peak load of the rejuvenated asphalt was investigated. Rejuvenator was applied (10% by weight of binder) to specimens aged 36 hours at 135 °C, and the dwell time was varied from 1 to 4 weeks. The results showed that the peak loads were restored to levels of the virgin specimens, and the fracture energies improved to levels beyond that of the virgin specimens. The results also showed a

Outcomes of polydioxanone knotless thread lifting for facial rejuvenation.

Science.gov (United States)

Suh, Dong Hye; Jang, Hee Won; Lee, Sang Jun; Lee, Won Seok; Ryu, Hwa Jung

2015-06-01

Thread lifting is a minimally invasive technique for facial rejuvenation. Various devices for thread lifting using polydioxanone (PDO) are popular in aesthetic clinics in Korea, but there have been a few studies regarding its use. To describe PDO thread and techniques adopted to counteract the descent and laxity of the face. A retrospective chart review was conducted over a 24-month period. A total of 31 thread lifting procedures were performed. On each side, 5 bidirectional cog threads were used in the procedure for the flabby skin of the nasolabial folds. And, the procedure was performed on the marionette line using 2 twin threads. In most patients (87%), the results obtained were considered satisfactory. Consensus ratings by 2 physicians found that objective outcomes were divided among "excellent," "good," "fair," and "poor." Texture wise, the outcome ratings were 13 as excellent and 9 as good. Lifting wise, ratings were 11 as excellent and 6 as good. The incidence of complications was low and not serious. Facial rejuvenation using PDO thread is a safe and effective procedure associated with only minor complications when performed on patients with modest face sagging, fine wrinkles, and marked facial pores.

Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease [version 1; referees: 3 approved

Directory of Open Access Journals (Sweden)

Alana M. Horowitz

2017-08-01

Full Text Available Neurodegenerative diseases are a devastating group of conditions that cause progressive loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing number of older individuals. Attempts to slow neurodegenerative disease advancement have met with little success in the clinic; however, a new therapeutic approach may stem from classic interventions, such as caloric restriction, exercise, and parabiosis. For decades, researchers have reported that these systemic-level manipulations can promote major functional changes that extend organismal lifespan and healthspan. Only recently, however, have the functional effects of these interventions on the brain begun to be appreciated at a molecular and cellular level. The potential to counteract the effects of aging in the brain, in effect rejuvenating the aged brain, could offer broad therapeutic potential to combat dementia-related neurodegenerative disease in the elderly. In particular, results from heterochronic parabiosis and young plasma administration studies indicate that pro-aging and rejuvenating factors exist in the circulation that can independently promote or reverse age-related phenotypes. The recent demonstration that human umbilical cord blood similarly functions to rejuvenate the aged brain further advances this work to clinical translation. In this review, we focus on these blood-based rejuvenation strategies and their capacity to delay age-related molecular and functional decline in the aging brain. We discuss new findings that extend the beneficial effects of young blood to neurodegenerative disease models. Lastly, we explore the translational potential of blood-based interventions, highlighting current clinical trials aimed at addressing therapeutic applications for the treatment of dementia-related neurodegenerative disease in humans.

RNA transcription in isolated chloroplasts during senescence and rejuvenation of intact cotyledons of CUCURBITA PEPO L. (ZUCCHINI)

International Nuclear Information System (INIS)

Mishev, K.; Ananiev, E.; Denev, L.; Radeva, G.

2006-01-01

RNA transcription was studied in intact chloroplasts isolated from cotyledons of Cucurbita pepoL. (zucchini) during their growth and development including natural senescence and rejuvenation. Rejuvenation of cotyledons was studied after decapitation of the epicotyl above the senescing yellow cotyledons. Maximal incorporation of [32P] UTP into overall chloroplast RNA was measured two days after exposure of seedlings to light (day 6 th after the onset of germination), followed by a gradual decrease reaching minimal values at the age of 25-28 days when cotyledons began to yellow and eventually die. Rejuvenation of cotyledons completely restored chloroplast RNA synthesis and fifteen days after decapitation (at the age of 40 days), the values of chloroplast transcription even exceeded that of the maximal transcriptional activity in young cotyledons. Inhibitory analysis with tagetitoxin (a specific inhibitor of plastid encoded chloroplast RNA polymerase (PEP)) showed that in young and rejuvenated cotyledons about 85% of chloroplast RNA polymerase activity was due to PEP and only 15% corresponded to the nuclear encoded plastid RNA polymerase (NEP). Definite regions of two chloroplast encoded genes were amplified by means of PCR technique using specific DNA primers for Rubisco large subunit gene (rbcL) and the housekeeping gene for chloroplast 16S rRNA as well as chloroplast DNA as a template. The appropriate lengths of the amplified DNA fragments were checked by restriction analysis

[The development of clinical application of the rejuvenator and a study of its mechanism for the treatment of functional erectile dysfunction].

Science.gov (United States)

Meng, Z; Zou, Y; Luo, E; Zou, L

2001-12-01

In this paper, we describe the development and clinical application of the Rejuvenator and report the result of our study on its mechanism for the treatment of functional erectile dysfunction (FED). The Rejuvenator, which can be used both at home and in hospitals to treat patients with FED, was developed on the basis of our clinical practice in the light of the modern theory of traditional Chinese medicine and by integrating multiple techniques of engineering science. It works by means of the paraoral use of the special herbal medicine, electro-magnetic effects, thermal moxibustion and drug-ingression. 2250 patients with FED received the treatment. Using combined electro-neurophysiological techniques, pulsed ultrasound Doppler and microcomputer image-scanning, we further studied the mechanism of the Rejuvenator for the treatment of FED. The total effective rate was 92%. The clinical data and result of study indicate that the Rejuvenator for the patients with functional erectile dysfunction is a safe, effective and scientific new method.

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study

OpenAIRE

Abuaf, Ozlem Karabudak; Yildiz, Hamza; Baloglu, H?seyin; Bilgili, Memet Ersan; Simsek, Hasan Aktug; Dogan, Bilal

2016-01-01

Background Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. Objective This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. Methods This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical st...

Facial exercises for facial rejuvenation: a control group study.

Science.gov (United States)

De Vos, Marie-Camille; Van den Brande, Helen; Boone, Barbara; Van Borsel, John

2013-01-01

Facial exercises are a noninvasive alternative to medical approaches to facial rejuvenation. Logopedists could be involved in providing these exercises. Little research has been conducted, however, on the effectiveness of exercises for facial rejuvenation. This study assessed the effectiveness of 4 exercises purportedly reducing wrinkles and sagging of the facial skin. A control group study was conducted with 18 participants, 9 of whom (the experimental group) underwent daily training for 7 weeks. Pictures taken before and after 7 weeks of 5 facial areas (forehead, nasolabial folds, area above the upper lip, jawline and area under the chin) were evaluated by a panel of laypersons. In addition, the participants of the experimental group evaluated their own pictures. Evaluation included the pairwise presentation of pictures before and after 7 weeks and scoring of the same pictures by means of visual analogue scales in a random presentation. Only one significant difference was found between the control and experimental group. In the experimental group, the picture after therapy of the upper lip was more frequently chosen to be the younger-looking one by the panel. It cannot be concluded that facial exercises are effective. More systematic research is needed. © 2013 S. Karger AG, Basel.

Lymphedema Fat Graft: An Ideal Filler for Facial Rejuvenation

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Fabio Nicoli

2014-09-01

Full Text Available Lymphedema is a chronic disorder characterized by lymph stasis in the subcutaneous tissue. Lymphatic fluid contains several components including hyaluronic acid and has many important properties. Over the past few years, significant research has been performed to identify an ideal tissue to implant as a filler. Because of its unique composition, fat harvested from the lymphedema tissue is an interesting topic for investigation and has significant potential for application as a filler, particularly in facial rejuvenation. Over a 36-month period, we treated and assessed 8 patients with lymphedematous limbs who concurrently underwent facial rejuvenation with lymphedema fat (LF. We conducted a pre- and post-operative satisfaction questionnaire survey and a histological assessment of the harvested LF fat. The overall mean general appearance score at an average of 6 months after the procedure was 7.2±0.5, demonstrating great improvement. Patients reported significant improvement in their skin texture with a reading of 8.5±0.7 and an improvement in their self-esteem. This study demonstrates that LF as an ideal autologous injectable filler is clinically applicable and easily available in patients with lymphedema. We recommend the further study and clinical use of this tissue as it exhibits important properties and qualities for future applications and research.

Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients.

Science.gov (United States)

Park, Kui Young; Seok, Joon; Rho, Nark Kyoung; Kim, Beom Joon; Kim, Myeung Nam

2016-01-01

Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill the space, but improve tissue regeneration, resulting in more natural tissue regeneration. Five Korean women received four times injections of long-chain PN filler in two-week intervals for skin rejuvenation. About 0.05 mL of material was injected in 40 points of one-side cheek. The pore and skin thickness were markedly improved in the patients in their 30s, whereas skin tone, melanin, wrinkles, and sagging were noticeably improved for patients in their 40s. There are no serious side effects. In conclusion, intradermal long-chain PN filler injection seems to be an effective and safe treatment for skin rejuvenation. © 2015 Wiley Periodicals, Inc.

What will it take to rejuvenate nuclear energy?

International Nuclear Information System (INIS)

Kadak, A.

2000-01-01

The issue of rejuvenation of nuclear energy on a worldwide basis will require several fundamental changes. These changes include how we design them, license them and operate them. While on the surface these changes may seem overwhelming, they are prerequisites to nuclear energy's re-emergence as a viable electric energy source. The requirements for new nuclear technology are that the plants must be competitive; they must be 'demonstrably' safe; they must be proliferation resistant; and finally they must exist in the current political climate. (authors)

The composition and distribution of the rejuvenated component across the Hawaiian plume: Hf-Nd-Sr-Pb isotope systematics of Kaula lavas and pyroxenite xenoliths

Science.gov (United States)

Bizimis, Michael; Salters, Vincent J. M.; Garcia, Michael O.; Norman, Marc D.

2013-10-01

Rejuvenated volcanism refers to the reemergence of volcanism after a hiatus of 0.5-2 Ma following the voluminous shield building stage of Hawaiian volcanoes. The composition of the rejuvenated source and its distribution relative to the center of the plume provide important constraints on the origin of rejuvenated volcanism. Near-contemporaneous lavas from the Kaula-Niihau-Kauai ridge and the North Arch volcanic field that are aligned approximately orthogonally to the plume track can constrain the lateral geochemical heterogeneity and distribution of the rejuvenated source across the volcanic chain. Nephelinites, phonolites and pyroxenite xenoliths from Kaula Island have radiogenic Hf, Nd and unradiogenic Sr isotope compositions consistent with a time-integrated depleted mantle source. The pyroxenites and nephelinites extend to the lowest 208Pb/204Pb reported in Hawaiian rocks. These data, along with new Pb isotope data from pyroxenites from the Salt Lake Crater (Oahu) redefine the composition of the depleted end-member of the Hawaiian rejuvenated source at 208Pb/204Pb=37.35±0.05, 206Pb/204Pb = 17.75±0.03, ɛNd = 9-10, ɛHf ˜16-17 and 87Sr/88Sr Niihau-Kauai-North Arch transect are consistent with a larger proportion of the rejuvenated depleted component in the periphery of the plume track rather than along its axis.

Short-pulsed laser for the treatment of tattoos, pigmented lesions, scars and rejuvenation.

Science.gov (United States)

Tanghetti, Emil A; Hoffmann, Kristina Andrea; Hoffmann, Klaus

2017-12-01

This review describes the use of picosecond lasers for the treatment of tattoos, pigmented lesions, scars, and their use in rejuvenation. These devices have delivered enhanced efficacy for the treatment of tattoos and pigmented lesions when compared to the older 40-50 nanosecond devices. The fractional delivery with the picosecond devices have opened up a new method of rejuvenation for photodamaged skin and the treatment of scars. The delivery of these high-energy short pulses have created zones of injury in the skin referred to as areas of laser-induced optical breakdown. These areas of damage appear to produce cytokines and chemokines which result in epidermal and dermal repair and remodeling. The dual use of these devices with the flat and the fractional optics have made these devices useful in many ways that have been unanticipated. ©2017 Frontline Medical Communications.

Quantitative evaluation of rejuvenators to restore embrittlement temperatures in oxidized asphalt mixtures using acoustic emission

Science.gov (United States)

Sun, Zhe; Farace, Nicholas; Arnold, Jacob; Behnia, Behzad; Buttlar, William G.; Reis, Henrique

2015-03-01

Towards developing a method capable to assess the efficiency of rejuvenators to restore embrittlement temperatures of oxidized asphalt binders towards their original, i.e., unaged values, three gyratory compacted specimens were manufactured with mixtures oven-aged for 36 hours at 135 °C. In addition, one gyratory compacted specimen manufactured using a short-term oven-aged mixture for two hours at 155 °C was used for control to simulate aging during plant production. Each of these four gyratory compacted specimens was then cut into two cylindrical specimen 5 cm thick for a total of six 36-hour oven-aged specimens and two short term aging specimens. Two specimens aged for 36 hours and the two short-term specimens were then tested using an acoustic emission approach to obtain base acoustic emission response of short-term and severely-aged specimens. The remaining four specimens oven-aged for 36 hours were then treated by spreading their top surface with rejuvenator in the amount of 10% of the binder by weight. These four specimens were then tested using the same acoustic emission approach after two, four, six, and eight weeks of dwell time. It was observed that the embrittlement temperatures of the short-term aged and severely oven-aged specimens were -25 °C and - 15 °C, respectively. It was also observed that after four weeks of dwell time, the rejuvenator-treated samples had recuperated the original embrittlement temperatures. In addition, it was also observed that the rejuvenator kept acting upon the binder after four weeks of dwell time; at eight weeks of dwell time, the specimens had an embrittlement temperature about one grade cooler than the embrittlement temperature corresponding to the short-term aged specimen.

Eighteen-point abobotulinum toxin a upper face rejuvenation: an eye plastic perspective on 845 subjects.

Science.gov (United States)

Kashkouli, Mohsen Bahmani; Amani, Afsaneh; Jamshidian-Tehrani, Mansooreh; Yousefi, Sahar; Jazayeri, Anis Alsadat

2014-01-01

To report the method and results of 18-point Abobotulinum toxin A (ABO-BTA, Dysport) upper face rejuvenation on 845 subjects. In a retrospective chart review, all subjects (the first cycle of injection) with ABO-BTA upper face rejuvenation from 2003 to 2009 were included. Excluded were subjects with facial spastic disorders, injection after upper face lifting, and aberrant regeneration of facial nerves. Upper face rejuvenation included 18 points of injection at forehead creases (4), frown lines (5), bunny line (1), crow's feet (4 on both sides), and lower eyelid crease (4 on both sides). They were revisited in 10 to 14 days for assessment of the effects and possible touch-up injection. Demographics, year of injection, topical anesthetic usage, touch-up injection, and adverse effects (AE) were recorded. There were 845 subjects (85.8% women) whose age was below 40 in 49.3%. All but 68 (8%) were happy with the touch-up visit, 10 to 14 days after injection. Touch-up injection was performed in 8% of subjects mainly for the eyebrow asymmetry. AE (22/845, 2.6%) were bruise (15/845, 1.8%), blepharoptosis (3/845, 0.3%), remained eyebrow asymmetry after touch-up injection (2/845, 0.2%), and headache (2/845, 0.2%). They were significantly more in subjects with touch-up injection, younger than 40 years, and in the first and second year of experience (especially for the bruise). Eighteen-point ABO-BTA upper face rejuvenation had a low rate of AE in this series in which majority was bruise at the lateral canthal area. They were significantly more in the first years of experience, subjects younger than 40, and who had touch-up injections.

Experimental Investigation on Asphalt Binders Ageing Behavior and Rejuvenating Feasibility in Multicycle Repeated Ageing and Recycling

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Yihua Nie

2018-01-01

Full Text Available Multicycle repeated utilization of reclaimed asphalt pavement (RAP is a quite recent development of sustainable pavement materials technology. To investigate ageing rules and recycling possibility of asphalt binders in repeatedly used asphalt mixture, virgin asphalt AH-70 samples were heated by the rolling thin film oven test (RTFOT at 163°C, respectively, for 40, 85, 180, 240, and 300 minutes to simulate different ageing degrees, and then the aged ones were rejuvenated by adding a self-made rejuvenator. This ageing and recycling process was repeated altogether for 5 cycles to simulate repeated use of RAP binders. In repeated recycling, rejuvenator contents for different cycle numbers or ageing durations were not the same, and the optimum ones were initially estimated by an empirical formula and finally obtained by comparative tests. Empirical rheological tests and the infrared spectral (IR analysis were done before and after each cycle of recycling. Results indicate that for impact on deterioration of asphalt binders, ageing time is more important than cycle number. Meanwhile, the asphalt after multicycle repeated ageing and recycling can be restored to the empirical rheological indices level of the virgin asphalt and meet specifications requirements.

[Benefits of volumetric to facial rejuvenation. Part 1: Fat grafting].

Science.gov (United States)

Bui, P; Lepage, C

2017-10-01

For a number of years, a volumetric approach using autologous fat injection has been implemented to improve cosmetic outcome in face-lift procedures and to achieve lasting rejuvenation. Autologous fat as filling tissue has been used in plastic surgery since the late 19th century, but has only recently been associated to face lift procedures. The interest of the association lies on the one hand in the pathophysiology of facial aging, involving skin sag and loss of volume, and on the other hand in the tissue induction properties of grafted fat, "rejuvenating" the injected area. The strict methodology consisting in harvesting, treating then injecting an autologous fat graft is known as LipoStructure ® or lipofilling. We here describe the technique overall, then region by region. It is now well known and seems simple, effective and reproducible, but is nevertheless delicate. For each individual, it is necessary to restore a harmonious face with well-distributed volumes. By associating volumetric to the face lift procedure, the plastic surgeon plays a new role: instead of being a tailor, cutting away excess skin, he or she becomes a sculptor, remodeling the face to restore the harmony of youth. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

The Rejuvenation of Cartography in ICT Era

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GUO Renzhong

2017-10-01

Full Text Available With the impetus of ICT, cartography faces the unprecedented challenges. The paper discusses the problems and changes of cartography facing the digital technology, analyzes the constraints of traditional cartography that are mainly delimited by 2D physical paper map. Diverseness of modern cartography shows various map products, and the paper illustrates the digital freedom in information space of modern cartography from eight aspects, including physical reality VS virtual reality, paper map VS digital map, superficial visualization VS inner visualization and so on. Modern cartography encounters the new development opportunities and fresh demands in digital era, and it's necessary to extend the framework of cartography and to assimilate newly sprouted things to promote the rejuvenation of cartography.

Facial rejuvenation starts in the midface: three-dimensional volumetric facial rejuvenation has beneficial effects on nontreated neighboring esthetic units.

Science.gov (United States)

Wollina, Uwe

2016-03-01

Facial aging is a major indication for minimal invasive esthetic procedures. Dermal fillers are a cornerstone in the approach for facial sculpturing. But where to start? Our concept is midfacial volume restoration in first place. This will result in a healthy and youthful appearance creating a facial V-shape. But midfacial filler injection does not only improve the malar area. It has also beneficial effects on neighboring esthetic units. We report on such improvements in periocular and nasolabial region, upper lips and perioral tissue, and the jaw line and discuss anatomical background. We hypothesize that midfacial deep filler injections also may activate subdermal white adipose tissue stem cells contributing to longer lasting rejuvenation. © 2015 Wiley Periodicals, Inc.

Minimally invasive non-thermal laser technology using laser-induced optical breakdown for skin rejuvenation

NARCIS (Netherlands)

Habbema, L.; Verhagen, R.; Van Hal, R.; Liu, Y.; Varghese, B.

2011-01-01

We describe a novel, minimally invasive laser technology for skin rejuvenation by creating isolated microscopic lesions within tissue below the epidermis using laser induced optical breakdown. Using an in-house built prototype device, tightly focused near-infrared laser pulses are used to create

Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians.

Science.gov (United States)

Chan, Nicola P Y; Ho, Stephanie G Y; Yeung, Chi K; Shek, Samantha Y N; Chan, Henry H

2010-11-01

Ablative fractional resurfacing (AFR) is a new modality for photorejuvenation and acne scars which combines carbon dioxide (CO₂) laser ablation with fractional photothermolysis. The objective is to evaluate the efficacy and side effects of a new fractional CO₂ ablative device (Fraxel Re:pair) for skin rejuvenation and acne scars in Asians. Nine patients underwent one full-face treatment. The energy levels ranged from 30-70 mJ with coverage between 30% and 45%. Improvement in skin texture, laxity, wrinkles, enlarged pores, overall pigmentation irregularity, and adverse effects were assessed up to 6 months post-treatment. Standardized photographs using the Canfield Visia CR system® were assessed by two independent observers. Subjective improvement was assessed by patient questionnaires. Nine Chinese patients (skin types III and IV, mean age 44.8) were included. Statistically significant improvements were seen for skin texture, skin laxity, wrinkles, enlarged pores, and acne scars. The post-inflammatory hyperpigmentation rate was 55.5% and 11.1% at 1 and 6 months post-treatment, respectively. Eighty-six percent of patients were overall satisfied to very satisfied with the treatment. Ablative fractional CO₂ laser resurfacing was overall safe and effective for skin rejuvenation and acne scars in Asians. However, in view of the high post-inflammatory rate and the statistically significant but only mild to moderate improvement after a single treatment as observed in this study, there is a need to review the current role of fractional ablative CO₂ laser treatment as compared to fractional non-ablative for skin rejuvenation and acne scar treatment in Asians. © 2010 Wiley-Liss, Inc.

The rejuvenation of TRISTAN control system

International Nuclear Information System (INIS)

Mimashi, T.; Urakawa, J.; Kurokawa, S.; Kawamoto, T.; Takeda, S.; Akiyama, A.; Kudoh, K.; Komada, K.; Naitoh, T.

1992-01-01

The current TRISTAN accelerator control system uses CAMAC as a front end electronics, and they are controlled by twenty five Hitachi minicomputer HIDIC 80's which are linked with an N-to-N token ring network. After five years from now, these computers must be replaced. This is because of the life time of control system and we have to cope with the requirements imposed by our future project such as the KEK B-Factory and the main ring photon factory projects. The rejuvenation of this control has to be done under some constraints such as the lack of manpower, limited time and financing. First we review the problems of current control system, then the philosophy of the new generation control system is presented. Finally it is discussed how to move to the new generation control system from the current TRISTAN control system. (author)

A new minimally invasive mesotherapy technique for facial rejuvenation.

Science.gov (United States)

Savoia, Antonella; Landi, Simone; Baldi, Alfonso

2013-06-01

This study describes a pivotal clinical trial of a new minimally invasive mesotherapy technique for facial rejuvenation. The authors utilized two formulations: formulation A with hyaluronic acid, vitamins, amino acids, minerals, coenzymes, and antioxidant substances; formulation B with hyaluronic acid and idebenone. Fifty participants were enrolled in the study and divided in two groups. Group 1 (50-65 years) treated with formulation A. Group 2 (35-50 years) treated with formulation B. The groups underwent four sessions of mesotherapy involving multiple injections. Treatment was conducted at 15 day intervals. All participants had pre- and posttreatment photographs. Punch biopsies were taken from randomly selected participants, baseline and after 6 weeks, and stained for interleukin (IL)-6, IL-1β, matrix metalloproteinase (MMP)-1, and collagen 1. Clinical evaluation was based on the Global Aesthetic Scale (GAIS) and on the Wrinkle Severity Rating Scale (WSRS). The results produced were statistically analyzed and resulted in a significant and long-lasting effect on facial rejuvenation. Evaluation of photographs at 0, 1, and 2 months revealed significant clinical improvement: brightness, texture, and firmness of the skin. The analysis of the GAIS and WSRS scores in the two groups demonstrated statistically significant results after 2 months. The biopsies taken from randomly selected participants at baseline and after 3 months showed a decrease in IL-1β, IL-6, and MMP1, and an increase in collagen 1. The new minimally invasive mesotherapy technique described can improve the clinical appearance of the skin in different age groups.

Mesotherapy for facial skin rejuvenation: a clinical, histologic, and electron microscopic evaluation.

Science.gov (United States)

Amin, Snehal P; Phelps, Robert G; Goldberg, David J

2006-12-01

Mesotherapy, as broadly defined, represents a variety of minimally invasive techniques in which medications are directly injected into the skin and underlying tissue in order to improve musculoskeletal, neurologic, and cosmetic conditions. There are few clinical studies evaluating the efficacy and safety of mesotherapy in any form. This study evaluates the histologic and clinical changes associated with one of the simplest formulations of mesotheraphy commonly used for skin rejuvenation. Ten subjects underwent four sessions of mesotherapy involving multiple injections of a multivitamin and hyaluronic acid solution. Treatment was conducted at 4 monthly intervals. All subjects had pre- and post-treatment photographs and skin biopsies. Skin biopsies were evaluated with routine histology, mucin and elastin stains, and electron microscopy. Patient surveys were also evaluated. Evaluation of photographs at 0, 3, and 6 months revealed no significant clinical differences. Light microscopic examination of pre- and posttreatment specimens showed no significant changes. Electron microscopic analysis of collagen fibers measurements did show smaller diameter fibres posttreatment. No significant clinical or histologic changes were observed after multivitamin mesotherapy for skin rejuvenation. Multivitamin and hyaluronic acid solution facial mesotherapy does not appear to provide any significant benefit.

Rejuvenation capacity of red blood cells in additive solutions over long-term storage.

Science.gov (United States)

Meyer, Erin K; Dumont, Deborah F; Baker, Sharry; Dumont, Larry J

2011-07-01

Red blood cells (RBCs) are Food and Drug Administration (FDA)-approved for 42-day storage with the use of additive solutions (ASs). However, adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (2,3-DPG) levels in the RBCs decline over this time. These constituents may be restored by treatment with rejuvenation (REJ) solutions. This study was done to assess the response capability of RBCs from 30 to 120 days of storage in three FDA-licensed RBC storage solutions after incubation with a rejuvenating solution of pyruvate, inosine, phosphate, and adenine. Three units each of RBCs in approved AS (AS-1 [Adsol, Fenwal, Inc.], AS-3 [Nutricel, Medsep Corp.], and AS-5 [Optisol, Terumo Corp.]) were stored under standard conditions at 1 to 6°C for up to 120 days. Aliquots (4 mL) on Days 30, 42, 60, 80, 100, and 120 (± 2 days) were REJ by incubating with Rejuvesol (Encyte Corp.). Control untreated and REJ aliquots were extracted using perchloric acid and stored at -80°C until assayed for 2,3-DPG and ATP. RBCs responded to REJ by increasing DPG and ATP contents. The response declined linearly at 0.070 ± 0.008 µmol DPG/g hemoglobin (Hb)/day and 0.035 ± 0.004 µmol ATP/g Hb/day with no differences between ASs. We conclude that Rejuvesol is able to restore ATP and 2,3-DPG levels in RBCs stored up to 120 days in AS. The response diminishes as storage time increases. This rejuvenation (REJ) capability does not seem useful for routine assessment of RBC anabolic capacity in research programs, but may be useful to the investigator when studying unique and novel treatment methods. © 2011 American Association of Blood Banks.

Evaluation of bio-materials’ rejuvenating effect on binders for high-reclaimed asphalt content mixtures

Directory of Open Access Journals (Sweden)

A. Jiménez del Barco-Carrión

2017-07-01

Full Text Available The interest in using bio-materials in pavement engineering has grown significantly over the last decades due to environmental concerns about the use of non-recoverable natural resources. In this paper, bio-materials are used together with Reclaimed Asphalt (RA to restore some of the properties of the aged bitumen present in mixtures with high RA content. For this purpose, two bio-materials are studied and compared to conventional and polymer modified bitumens. Blends of these materials with RA bitumen were produced and studied to simulate a 50% RA mixture. The rejuvenating effect of the two bio-materials on RA has been assessed and compared with the effect of the conventional binders. Apparent Molecular Weight Distribution of the samples (obtained by the ?-method and different rheological parameters were used for this purpose. Results revealed the power of bio-materials to rejuvenate RA bitumen, showing their capability to be used as fresh binders in high-RA content mixtures.

Evaluation of bio-materials’ rejuvenating effect on binders for high-reclaimed asphalt content mixtures

International Nuclear Information System (INIS)

Jiménez del Barco-Carrión, A.; Pérez-Martínez, M.; Themeli, A.; Lo Presti, D.; Marsac, P.; Pouget, S.; Hammoum, F.; Chailleux, E.; Airey, G.D.

2017-01-01

The interest in using bio-materials in pavement engineering has grown significantly over the last decades due to environmental concerns about the use of non-recoverable natural resources. In this paper, bio-materials are used together with Reclaimed Asphalt (RA) to restore some of the properties of the aged bitumen present in mixtures with high RA content. For this purpose, two bio-materials are studied and compared to conventional and polymer modified bitumens. Blends of these materials with RA bitumen were produced and studied to simulate a 50% RA mixture. The rejuvenating effect of the two bio-materials on RA has been assessed and compared with the effect of the conventional binders. Apparent Molecular Weight Distribution of the samples (obtained by the ?-method) and different rheological parameters were used for this purpose. Results revealed the power of bio-materials to rejuvenate RA bitumen, showing their capability to be used as fresh binders in high-RA content mixtures. [es

The efficacy of conditioned media of adipose-derived stem cells combined with ablative carbon dioxide fractional resurfacing for atrophic acne scars and skin rejuvenation.

Science.gov (United States)

Zhou, Bing-Rong; Zhang, Ting; Bin Jameel, Afzaal Ahmed; Xu, Yang; Xu, Yan; Guo, Shi-Lei; Wang, Ying; Permatasari, Felicia; Luo, Dan

2016-06-01

To evaluate the effects of conditioned medium of adipose-derived stem cells (ADSC-CM) on efficacy and side effects after fractional carbon dioxide laser resurfacing (FxCR) when treating subjects with facial atrophic acne scars or with skin rejuvenation needs. Twenty-two subjects were enrolled in the study and divided into two groups. Nine subjects were included in skin rejuvenation group and thirteen subjects were included in acne scar group, and all subjects underwent three sessions of FxCR. ADSC-CM was applied on FxCR site of one randomly selected face side. Evaluations were done at baseline, 1 week after first treatment, and 1 month after each treatment. The outcome assessments included subjective satisfaction scale; blinded clinical assessment; and the biophysical parameters of roughness, elasticity, skin hydration, transepidermal water loss (TEWL), and the erythema and melanin index. Biopsies taken from one subject in skin rejuvenation group were analyzed using hematoxylin and eosin, Masson's Trichrome, and Gomori's aldehyde fuchsin staining. ADSC-CM combined with FxCR increased subject satisfaction, elasticity, skin hydration, and skin elasticity and decreased TEWL, roughness, and the melanin index in both acne scars and skin rejuvenation groups. Histologic analysis showed that ADSC-CM increased dermal collagen density, elastin density, and arranged them in order. ADSC-CM with FxCR is a good combination therapy for treating atrophic acne scars and skin rejuvenation. JSPH2012-082 - Registered 14 Feb 2012.

Localized rejuvenation of a crystal mush recorded in zircon temporal and compositional variation at the Lassen Volcanic Center, northern California.

Directory of Open Access Journals (Sweden)

Erik W Klemetti

Full Text Available Zircon ages and trace element compositions from recent silicic eruptions in the Lassen Volcanic Center (LVC allow for an evaluation of the timing and conditions of rejuvenation (reheating and mobilization of crystals within the LVC magmatic system. The LVC is the southernmost active Cascade volcano and, prior to the 1980 eruption of Mount St. Helens, was the site of the only eruption in the Cascade arc during the last century. The three most recent silicic eruptions from the LVC were very small to moderate-sized lava flows and domes of dacite (1915 and 27 ka eruptions of Lassen Peak and rhyodacite (1.1 ka eruption of Chaos Crags. These eruptions produced mixed and mingled lavas that contain a diverse crystal cargo, including zircon. 238U-230Th model ages from interior and surface analyses of zircon reveal ages from ∼17 ka to secular equilibrium (>350 ka, with most zircon crystallizing during a period between ∼60-200 ka. These data support a model for localized rejuvenation of crystal mush beneath the LVC. This crystal mush evidently is the remnant of magmatism that ended ∼190 ka. Most zircon are thought to have been captured from "cold storage" in the crystal mush (670-725°C, Hf >10,000 ppm, Eu/Eu* 0.25-0.4 locally remobilized by intrusion of mafic magma. A smaller population of zircon (>730°C, Hf 0.4 grew in, and are captured from, rejuvenation zones. These data suggest the dominant method to produce eruptible melt within the LVC is small-scale, local rejuvenation of the crystal mush accompanied by magma mixing and mingling. Based on zircon stability, the time required to heat, erupt and then cool to background conditions is relatively short, lasting a maximum of 10 s-1000 s years. Rejuvenation events in the LVC are ephemeral and permit eruption within an otherwise waning and cooling magmatic body.

A single-blinded randomised controlled study to determine the efficacy of Omnilux Revive facial treatment in skin rejuvenation.

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Bhat, Jaideep; Birch, Jan; Whitehurst, Colin; Lanigan, Sean W

2005-01-01

To determine the efficacy of Omnilux Revive facial treatment in skin rejuvenation, twenty-three volunteers received randomised 20 min treatments three times a week for three weeks to one half of their face, with the untreated side acting as control. Regular assessments were carried out, focusing on parameters of subject satisfaction, photographic assessments, skin elasticity (Cutometer) and skin hydration (Corneometer CM825). Ninety-one percent of the volunteers reported visible changes to their skin. Blinded photographic evaluation reported a clinical response in 59% of the subjects. Objective analysis failed to show statistically significant changes in skin hydration or elasticity. The Omnilux Revive LED lamp is a safe alternative non-ablative skin rejuvenation treatment.

Efficacy of mesotherapy in facial rejuvenation: a histological and immunohistochemical evaluation.

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El-Domyati, Moetaz; El-Ammawi, Tarek S; Moawad, Osama; El-Fakahany, Hasan; Medhat, Walid; Mahoney, Mỹ G; Uitto, Jouni

2012-08-01

Mesotherapy, commonly known as "biorejuvenation" or "biorevitalization", is a technique used to rejuvenate the skin by means of a transdermal injection of a multivitamin solution and natural plant extracts that are thought to improve the signs of skin aging. This prospective study aimed to evaluate the clinical effect of mesotherapy applied to periorbital wrinkles and to quantitatively evaluate histological changes in the skin occurring in response to the same treatment. Six volunteers with Fitzpatrick skin types III or IV and Glogau class I-III wrinkles were subjected to a three-month course of mesotherapy injections in the periocular area (six sessions administered at two-week intervals). Standard photographs and skin biopsies were obtained from the treatment area at baseline, at the end of treatment, and at three months post-treatment. Quantitative evaluation of collagen types I, III, and VII, newly synthesized collagen, total elastin, and tropoelastin was performed using a computerized morphometric analysis. The clinical evaluation of volunteers at baseline, end of treatment, and three months post-treatment revealed no significant differences. Histological and immunostaining analysis of collagen types I, III, and VII, newly synthesized collagen, total elastin, and tropoelastin showed no statistically significant changes (P > 0.05) after mesotherapy injection. The present study indicates that mesotherapy for skin rejuvenation does not result in statistically significant histological changes or clinical improvement. © 2012 The International Society of Dermatology.

Accelerated aging versus rejuvenation of the immune system in heterochronic parabiosis.

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Pishel, Iryna; Shytikov, Dmytro; Orlova, Tatiana; Peregudov, Alex; Artyuhov, Igor; Butenko, Gennadij

2012-04-01

The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, and others. Our investigations of heterochronic parabiosis have shown that benefits of a young immune system, e.g., actively working thymus and regular migration of young hematopoietic stem cells between parabiotic partners, appeared unable to restore the immune system of the old partner. At the same time, we have established a progressive immune impairment in the young heterochronic partners. The mechanism of age changes in the immune system in this model, which may lead to reduced life expectancy, has not been fully understood. The first age-related manifestation in the young partners observed 3 weeks after the surgery was a dramatic increase of CD8(+)44(+) cells population in the spleen. A detailed analysis of further changes revealed a progressive decline of most immunological functions observable for up to 3 months after the surgery. This article reviews possible mechanisms of induction of age-related changes in the immune system of young heterochronic partners. The data obtained suggest the existence of certain factors in the old organisms that trigger aging, thus preventing the rejuvenation process.

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study.

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Abuaf, Ozlem Karabudak; Yildiz, Hamza; Baloglu, Hüseyin; Bilgili, Memet Ersan; Simsek, Hasan Aktug; Dogan, Bilal

2016-12-01

Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. PRP injected to the upper site of this right infra-auricular area and all face. Saline was injected to the left infra-auricular area. Histopathological examinations were performed before PRP treatment, 28 days after the PRP, and saline (control) treatments. Twenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean optical densities (MODs) of collagen in the pre-treatment, control, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment. The mean MOD of collagen fibers was clearly highest on the PRP side ( p facial skin rejuvenation.

Split-face comparison of intense pulsed light and nonablative 1,064-nm Q-switched laser in skin rejuvenation.

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Huo, Meng-Hua; Wang, Yong-Qian; Yang, Xin

2011-01-01

Multiple nonablative skin rejuvenation techniques have been used to improve facial aging. To compare rejuvenation efficiency of intense pulsed light (IPL) with nonablative 1,064-nm Q-switched laser in Asian patients. Twelve female subjects were enrolled and received five sessions of treatments at 2-week intervals. A split-face study was performed, with IPL applied to the left side of the face and nonablative 1,064-nm Q-switched laser to the right side. All assessments showed significant skin rejuvenation. For the improvement of skin texture, pore size, and sebum secretion, similar efficiency from laser and IPL was observed. For lightening of skin tone and macula, the IPL was more efficient than the laser after the first treatment, although no further clinical improvement resulted after three treatments. The laser gradually lightened the skin tone and macula and was ultimately more efficient than the IPL after five treatments. A series of IPL and nonablative 1,064-nm Q-switched laser treatments were performed with similar efficiency and safety for the improvement in skin texture, pore size, and sebum secretion. IPL was faster, but nonablative 1,064-nm Q-switched laser was more effective in improving skin tone and macula. © 2010 by the American Society for Dermatologic Surgery, Inc.

Reliability tests for reactor internals rejuvenation technology

International Nuclear Information System (INIS)

Fujimaki, Katsumi; Hitoki, Yoichi; Otsubo, Toru; Uchiyama, Junichi

1998-01-01

Structural damage due to aging degradation of LWR reactor internals has been reported in several nuclear plants. NUPEC has started a project to test the reliability of the technology for rejuvenating reactor internals which has been funded by the Ministry of International Trade and Industry (MITI) of Japan since 1995. The project follows the policy of a report that the MITI has formally issued in April 1996 summarizing the countermeasures to be considered for aging nuclear plants and equipment. This paper gives an outline of the test plans and results which are directed at preventive maintenance before damage and repair after damage for reactor internals aging degradation. The test results for the replacement methods of ICM housing and BWR core shroud have shown that the methods were reliable and the structural integrity was appropriate based on the evaluation. (author)

Radiofrequency waves with filling and peeling substances: An innovative minimally invasive technique for facial rejuvenation.

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Savoia, Antonella; Vannini, Fulvio; Baldi, Alfonso

2011-09-01

This study describes a pivotal clinical trial of a new minimally invasive cosmetic procedure for facial rejuvenation and for the treatment of scars and wrinkles. The procedure consisted of a combination of techniques such as fillers, biorevitalization, peeling, and intradermal radiofrequency, emitted from a new device denominated by Spherofill Medical Plus (SMP; Spherofill MD, PromoItalia Group S.p.A., Pozzuoli, Italy), for treating cutaneous regeneration, depressions, and striae. One hundred and twelve patients, divided into five groups, were treated. The results produced were statistically analyzed and resulted in significant and long-lasting effects for facial rejuvenation. Indeed, the analysis of the Global Aesthetic Improvement Scale (GAIS) scores in the five groups demonstrated statistically significant results between 3 and 9 months after the treatments. Evaluating the patients included in the study, it is possible to conclude that the treatment with SMP represents a safe and efficient solution for the treatment of wrinkles, acne lesions, striae, and of degenerated tissues caused by aging.

Midface rejuvenation: a critical evaluation of a 7-year experience.

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Pascali, Michele; Botti, Chiara; Cervelli, Valerio; Botti, Giovanni

2015-05-01

Although "traditional" face-lifting techniques can achieve excellent improvement along the jawline and neck, they often have little impact on the midface area. Thus, many different types of procedures have been developed to provide rejuvenation in this region, usually contemplating various dissection planes, incisions, and suspension vectors. A 7-year observational study of 350 patients undergoing midface lift was analyzed. The authors suspended the midface flap, anchoring to the deep temporal aponeurosis with a suspender-like suture (superolateral vector), or directly to the lower orbital rim with a belt-like suture (superomedial vector). Subjective and objective methods were used to evaluate the results. The subjective methods included a questionnaire completed by the patients. The objective method involved the evaluation of preoperative and postoperative photographs by a three-member jury instructed to compare the "critical" anatomical areas of the midface region: malar eminence, nasojugal groove, nasolabial fold, and jowls in the lower portion of the cheeks. The average follow-up period was 24 months. High satisfaction was noticeable from the perceptions of both the jury and the patients. Objective evaluation evidenced that midface lift with temporal anchoring was more efficient for the treatment of malar eminence, whereas midface lift with transosseous periorbital anchoring was more efficient for the treatment of nasojugal groove. The most satisfying aspect of the adopted techniques is a dramatic facial rejuvenation and preservation of the patient's original youthful identity. Furthermore, choosing the most suitable technique respects the patient's needs and enables correction of the specific defects. Therapeutic, IV.

Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

Directory of Open Access Journals (Sweden)

Aldag C

2016-11-01

Full Text Available Caroline Aldag,1,* Diana Nogueira Teixeira,1,* Phillip S Leventhal2 1Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany; 24Clinics, Paris, France *These authors contributed equally to this work Abstract: Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size. In this review, we summarize the commercially available products containing growth factors, cytokines, and matrikines for which there is evidence that they promote skin rejuvenation. Keywords: cosmetics, skin, aging, growth factor, cytokine, matrikine

In Search for Anti-Aging Strategy: Can We Rejuvenate Our Aging Stem Cells?

Directory of Open Access Journals (Sweden)

Anna Meiliana

2015-08-01

Full Text Available BACKGROUND: Recent evidence suggested that we grow old partly because of our stem cells grow old as a result of mechanisms that suppress the development of cancer over a lifetime. We believe that a further, more precise mechanistic understanding of this process will be required before this knowledge can be translated into human anti-aging therapies. CONTENT: A diminished capacity to maintain tissue homeostasis is a central physiological characteristic of aging. As stem cells regulate tissue homeostasis, depletion of stem cell reserves and/or diminished stem cell function have been postulated to contribute to aging. It has further been suggested that accumulated DNA damage could be a principal mechanism underlying age-dependent stem cell decline. It is interesting that many of the rejuvenating interventions act on the stem cell compartments, perhaps reflecting shared genetic and biochemical pathways controlling stem cell function and longevity. Strategy to slow down the aging processes is based on caloric restriction refers to a dietary regimen low in calories but without undernutrition. Sirtuin (SIRT1 and 3, increases longevity by mimicking the beneficial effects of caloric restriction. SIRT3 regulates stress-responsive mitochondrial homeostasis, and more importantly, SIRT3 upregulation rejuvenates aged stem cells in tissues. Resveratrol (3,5,4’-trihydroxystilbene, a natural polyphenol found in grapes and wine, was the most powerful natural activator of SIRT1. In fact, resveratrol treatment has been demonstrated to rescue adult stem cell decline, slow down bodyweight loss, improve trabecular bone structure and mineral density, and significantly extend lifespan. SUMMARY: Tissue-specific stem cells persist throughout the entire lifespan to repair and maintain tissues, but their self-renewal and differentiation potential become dysregulated with aging. Given that adult stem cells are thought to be central to tissue maintenance and organismal

Theoretical paper: exploring overlooked natural mitochondria-rejuvenative intervention: the puzzle of bowhead whales and naked mole rats.

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Prokopov, Arkadi F

2007-12-01

There is an imperative need for exploring and implementing mitochondria-rejuvenative interventions that can bridge the current gap toward the step-by step realization of strategies for engineered negligible senescence (SENS) agenda. Recently discovered in mammals, natural mechanism mitoptosis-a selective "suicide" of mutated mitochondria-can facilitate continuous purification of mitochondrial pool in an organism from the most reactive oxygen species (ROS)-producing mitochondria. Mitoptosis, which is considered to be the first stage of ROS-induced apoptosis, underlies follicular atresia (a "quality control" mechanism in female germline cells that eliminates most germinal follicles in female embryos). Mitoptosis can be also activated in adult postmitotic somatic cells by evolutionary conserved phenotypic adaptations to intermittent oxygen restriction (IOR) and synergistically acting intermittent caloric restriction (ICR). IOR and ICR are common in mammals and seem to underlie extraordinary longevity and augmented cancer resistance in bowhead whales (Balena mysticetus) and naked mole rats (Heterocephalus glaber). Furthermore, in mammals IOR can facilitate continuous stromal stem cells-de-pendent tissue repair. A comparative analysis of IOR and ICR mechanisms in both mammals, in conjunction with the experience of decades of biomedical and clinical research on emerging preventative, therapeutic, and rehabilitative modality-the intermittent hypoxic training/therapy (IHT)-indicates that the notable clinical efficiency of IHT is based on the universal adaptational mechanisms that are common in mammals. Further exploration of natural mitochondria-preserving and -rejuvenating strategies can help refinement of IOR- and ICR-based synergistic protocols, having value in clinical human rejuvenation.

Aging, Clonality and Rejuvenation of Hematopoietic Stem Cells

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Akunuru, Shailaja; Geiger, Hartmut

2016-01-01

Aging is associated with reduced organ function and increased disease incidence. Hematopoietic stem cell (HSC) aging driven by both cell intrinsic and extrinsic factors is linked to impaired HSC self-renewal and regeneration, aging-associated immune remodeling, and increased leukemia incidence. Compromised DNA damage responses and increased production of reactive oxygen species have been previously causatively attributed to HSC aging. However, recent paradigm-shifting concepts such as global epigenetic and cytoskeletal polarity shifts, cellular senescence, as well as clonal selection of HSCs upon aging provide new insights into HSC aging mechanisms. Rejuvenating agents that can reprogram the epigenetic status of aged HSCs or senolytic drugs that selectively deplete senescent cells provide promising translational avenues for attenuating hematopoietic aging and potentially, alleviating aging-associated immune remodeling and myeloid malignancies. PMID:27380967

Effect of Bio based rejuvenator on mix design, Energy consumption and GHG Emission of High RAP Mixture

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Abdullahi Ahmad, Kabiru; Ezree Abdullah, Mohd; Hassan, Norhidayah Abdul; Usman, Nura; Hassan, Mohd Rosli Mohd; Bilema, Munder A. M.; Modibbo Saeed, Saeed; Batari, Ahmad

2018-04-01

Concerns about the cost, availability, and environmental impact of using petroleum-based materials have led to increased usage of reclaimed asphalt pavement (RAP). Mean-while, the demand of the road industry to decrease the energy consumptions and reduce the release of greenhouse gases as well as other harmful gases, which cause serious air pollution has increased due to the amount of energy consumed is a major component of pavement construction that significantly contributes to the total cost. This paper evaluates the effects of Biobased rejuvenator known as JCO on the required heat energy and the amount of CO2 produced to increase the temperature of RAP and virgin aggregates and one binder from 25C to the point of mixing. The results showed that incorporating Biobased rejuvenator (JCO) can potentially reduce the required heat energy and amount of greenhouse gas produced by RAP and virgin, respectively.

Multifractional microablative laser combined with spacially modulated ablative (SMA) technology for facial skin rejuvenation.

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Hersant, Barbara; SidAhmed-Mezi, Mounia; Chossat, Adrien; Meningaud, Jean Paul

2017-01-01

Due to the increasing demand for aesthetic procedures, especially facial aesthetic surgery, a new laser technology has been developed for facial skin rejuvenation and wrinkle treatment. The aim of this study was to objectively and subjectively assess the clinical efficacy and safety of Erbium:YAG laser combined with Spatially Modulated Ablation (Er:YAG + SMA) on facial skin rejuvenation. Patients with Fitzpatrick skin type's I-IV were prospectively included. Inclusion criteria consisted of having wrinkles and irregular skin texture. All patients underwent two Er:YAG + SMA sessions (1 month apart) to stimulate tissue regeneration. Er:YAG laser emits wavelength at 2,940 nm and when combined with SMA, a resonance effect is produced in the dermis to promote tissue regeneration. Facial skin elasticity and firmness were objectively assessed by Cutometer at baseline and month 6 (M6). Aesthetic improvement was qualitatively assessed using digital photographs. Patient satisfaction with regard to their facial appearance was self-assessed using the validated FACE-Q scale and the patient-perceived age VAS scale at baseline, M1, and M6. Side effects were investigated after each session. Thirty-four patients were included, 50% (18 patients) had Fitzpatrick skin type III and 41% (14 patients) were smokers. Skin elasticity indices were significantly improved: from 0.335 ± 0.015 at baseline to 0.387 ± 0.021 at M6 (P = 0.05*) for R5 (net elasticity). Skin firmness was assessed through R7 (biological elasticity) and R6 (viscoelastic ratio) at baseline and M6: a significant increase from 0.235 ± 0.01 to 0.2709 ± 0.009 (P technology offers an effective and safe treatment alternative for facial skin rejuvenation. It reduces the recovery time compared to conventional lasers such as carbon dioxide laser. Lasers Surg. Med. 49:78-83, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study

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Abuaf, Ozlem Karabudak; Baloglu, Hüseyin; Bilgili, Memet Ersan; Simsek, Hasan Aktug; Dogan, Bilal

2016-01-01

Background Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. Objective This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. Methods This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. PRP injected to the upper site of this right infra-auricular area and all face. Saline was injected to the left infra-auricular area. Histopathological examinations were performed before PRP treatment, 28 days after the PRP, and saline (control) treatments. Results Twenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean optical densities (MODs) of collagen in the pre-treatment, control, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment. The mean MOD of collagen fibers was clearly highest on the PRP side (pmesotherapy technique 'point by point'). PRP application could be considered as an effective (even a single application) and safety procedure for facial skin rejuvenation. PMID:27904271

Carbonatite and silicate melt metasomatism of the mantle surrounding the Hawaiian plume: Evidence from volatiles, trace elements, and radiogenic isotopes in rejuvenated-stage lavas from Niihau, Hawaii

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Dixon, Jacqueline; Clague, David A.; Cousens, Brian; Monsalve, Maria Luisa; Uhl, Jessika

2008-09-01

We present new volatile, trace element, and radiogenic isotopic compositions for rejuvenated-stage lavas erupted on Niihau and its submarine northwest flank. Niihau rejuvenated-stage Kiekie Basalt lavas are mildly alkalic and are isotopically similar to, though shifted to higher 87Sr/86Sr and lower 206Pb/204Pb than, rejuvenated-stage lavas erupted on other islands and marginal seafloor settings. Kiekie lavas display trace element heterogeneity greater than that of other rejuvenated-stage lavas, with enrichments in Ba, Sr, and light-rare earth elements resulting in high and highly variable Ba/Th and Sr/Ce. The high Ba/Th lavas are among the least silica-undersaturated of the rejuvenated-stage suite, implying that the greatest enrichments are associated with the largest extents of melting. Kiekie lavas also have high and variable H2O/Ce and Cl/La, up to 620 and 39, respectively. We model the trace element concentrations of most rejuvenated-stage lavas by small degrees (˜1% to 9%) of melting of depleted peridotite recently metasomatized by a few percent of an enriched incipient melt (0.5% melting) of the Hawaiian plume. Kiekie lavas are best explained by 4% to 13% partial melting of a peridotite source metasomatized by up to 0.2% carbonatite, similar in composition to oceanic carbonatites from the Canary and Cape Verde Islands, with lower proportion of incipient melt than that for other rejuvenated-stage lavas. Primary H2O and Cl of the carbonatite component must be high, but variability in the volatile data may be caused by heterogeneity in the carbonatite composition and/or interaction with seawater. Our model is consistent with predictions based on carbonated eclogite and peridotite melting experiments in which (1) carbonated eclogite and peridotite within the Hawaiian plume are the first to melt during plume ascent; (2) carbonatite melt metasomatizes plume and surrounding depleted peridotite; (3) as the plume rises, silica-undersaturated silicate melts are also

An evaluation of the efficiency of compartmented alginate fibres encapsulating a rejuvenator as an asphalt pavement healing system

NARCIS (Netherlands)

Tabaković, Amir; Karač, Aleksandar; Schlangen, H.E.J.G.

2017-01-01

This paper explores the potential methods for evaluating a healing system for asphalt pavements. The healing system under investigation involves compartmented calcium-alginate fibres encapsulating an asphalt binder healing agent (rejuvenator). This system presents a novel method of incorporating

[The opportunities, challenges and trends in the rejuvenation of microbiology].

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Shen, Ping; Chen, Xiangdong

2010-01-01

In history, the development of microbiology had undergone two golden ages and some depression time as well. In the last two decades, the application of many physiochemical technologies including genomics, structural biology, bioinformatics, PCR, and high-resolution microscopy has led to a series of breakthroughs in microbiology. Microbiology has now awakened and entered its third golden age for development. This review discusses our view of the opportunities, challenges, and trends in the current advancement of microbiology. The topics include: (1) The two golden ages for microbiology in history. (2) The opportunities and challenges in the rejuvenation of microbiology. (3) The characteristics and trends of the current development of microbiology. (4) Integral microbiology--the hallmark of the third golden age.

Rejuvenation of the male scalp using 1,927 nm non-ablative fractional thulium fiber laser.

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Boen, Monica; Wilson, Monique J Vanaman; Goldman, Mitchel P; Wu, Douglas C

2017-07-01

The male scalp undergoes extensive photodamage due to a high prevalence of androgenic alopecia and exposure to ultraviolet radiation. This photodamage presents as solar lentigines, fine rhytides, and keratosis, and can prematurely age a patient. In this study, we demonstrate the safety and efficacy of the fractionated 1,927 nm thulium fiber laser using high density and high energy settings to achieve rejuvenation of the male scalp after a single treatment session. Four male patients with Fitzpatrick skin types II-III and extensive photodamage on the scalp underwent one treatment with the fractional non-ablative 1,927 nm thulium fiber laser. The patients had a 60-90% improvement in dyspigmentation, lentigines, and keratosis. No adverse events were observed and the patients tolerated the procedure well. This case series is the first report in the literature demonstrating the successful rejuvenation of the scalp using the 1,927 nm thulium fiber laser. Lasers Surg. Med. 49:475-479, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

The effects of platelet-rich plasma on recovery time and aesthetic outcome in facial rejuvenation : preliminary retrospective observations

NARCIS (Netherlands)

Willemsen, Joep C N; van der Lei, Berend; Vermeulen, Karin M; Stevens, Hieronymus P J D

2014-01-01

BACKGROUND: This study focused on the possible effect of platelet-rich plasma (PRP) on recovery time and aesthetic outcome after facial rejuvenation. We conducted a retrospective analysis with regard to recovery time and the aesthetic improvement after treatment among four groups of patients: those

Towards cultural materialism in the medical humanities: the case of blood rejuvenation

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2018-01-01

This paper argues for an approach within the medical humanities that draws on the theoretical legacy of cultural materialism as a framework for reading cultural practices and their relationship to the social and economic order. It revisits the origins and development of cultural materialism in cultural studies and literary studies between the 1970s and 1990s and considers how, with adaptation, this methodology might facilitate ideological criticism focused on material formations of health, disease and the human body. I outline three key characteristics of a medicocultural materialist approach along these lines: (a) interdisciplinary work on a broad range of medical and cultural sources, including those drawn from ‘popular’ forms of culture; (b) the combination of historicist analysis with scrutiny of present-day contexts; (c) analyses that engage with political economy perspectives and/or the work of medical sociology in this area. The subsequent sections of the paper employ a medicocultural materialist approach to examine conjectural understandings of, and empirical investigations into, the capacity of transfused human blood to rejuvenate the ageing body. I trace textual faultlines that expose the structures of power which inform the movement of blood between bodies in ‘medical gothic’ fictions from the 19th-century fin de siècle, including Mary Elizabeth Braddon's ‘Good Lady Ducayne’ (1896) and Bram Stoker's Dracula (1897). I conclude with a critique of biomedical innovations in blood rejuvenation in the era of medical neoliberalism, before considering the potential applications of medicocultural materialism to other topics within the field of the medical humanities. PMID:28495908

Oil field rejuvenation work starts at 14 project sites

International Nuclear Information System (INIS)

Petzet, G.A.

1992-01-01

This paper reports that the U.S. Department of Energy and oil and gas companies have released more information about a joint effort to rejuvenate aging U.S. oil fields in danger of abandonment. Work is starting on 14 demonstration projects that could recover 21 million bbl of oil from the fluvial dominated deltaic (FDD) reservoirs in which they are conducted. Wider application of the same techniques, if they are successful, could results in addition of 6.3 billion bbl of reserves, nearly 25% of U.S. crude oil reserves. A multidisciplinary team approach is to be used, with as many as 11 operators, service companies, universities, or state agencies participating in each project. All of the projects will culminate in extensive technology transfer activities. Here are descriptions of the projects gleaned from public abstracts provided by the DOE contractors

Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin.

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Kim, Yoon-Jin; Yoo, Sae Mi; Park, Hwan Hee; Lim, Hye Jin; Kim, Yu-Lee; Lee, Seunghee; Seo, Kwang-Won; Kang, Kyung-Sun

2017-11-18

Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs. Moreover, we evaluated skin permeation of USC-CM Exos by using human skin tissues. Results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 h and gradually approached the epidermis after 18 h. Moreover, increased expressions of Collagen I and Elastin were found after 3 days of treatment on human skin. The results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin rejuvenation and shows the potential of USC-CM integration with the cosmetics or therapeutics. Copyright © 2017 Elsevier Inc. All rights reserved.

Versatility of erbium YAG laser: from fractional skin rejuvenation to full-field skin resurfacing.

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Holcomb, J David

2011-05-01

For the laser surgeon, the Er-YAG laser is an invaluable tool that delivers unsurpassed ablation efficiency, and with appropriate functionality (quasi long-pulse feature) provides sufficient tissue coagulation to remodel deep rhytids. As such, the 2940-nm wavelength is well suited for routine laser skin rejuvenation in full-field, fractional, and point-beam modes with additional benefits, including applicability to diverse skin types, short healing times, and a low likelihood of energy-related complications. Copyright © 2011 Elsevier Inc. All rights reserved.

A randomized, placebo-controlled, single-blinded, split-faced clinical trial evaluating the efficacy and safety of KLOX-001 gel formulation with KLOX light-emitting diode light on facial rejuvenation

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Nikolis A

2016-05-01

Full Text Available Andreas Nikolis,1 Steven Bernstein,2 Brian Kinney,3 Nicolo Scuderi,4 Shipra Rastogi,5 John S Sampalis6 1Victoria Park, Plastic Surgery Section, Westmount, QC, Canada; 2Dermatology Department, University of Montreal Health Centre, Montreal, QC, Canada; 3Department of Plastic Surgery, USC School of Medicine, Beverley Hills, CA, USA; 4Department of Plastic and Reconstructive Surgery, La Sapienza, Rome, Italy; 5KLOX Technologies, Laval, 6JSS Medical Research, Montreal, QC, Canada Purpose: Many treatment modalities exist to counteract the effects of cutaneous aging. Ablative methods have been the mainstay for nonsurgical facial rejuvenation. In recent years, nonablative techniques have been developed with the aim of achieving facial rejuvenation without epidermal damage. Light-emitting diode (LED photorejuvenation is a novel nonablative technique that induces collagen synthesis through biophotomodulatory pathways. Materials and methods: A single-center, randomized, single-blinded, placebo-controlled, split-faced clinical trial was designed. Thirty-two patients were enrolled for a 12-week study. Patients were randomized into one of four groups: Group A, treatment with KLOX-001 gel formulation and white LED (placebo light; Group B, treatment with a placebo/base gel (no active chromophore formulation and KLOX LED light; Group C, treatment with KLOX-001 gel formulation and KLOX LED light; and Group D, treatment with the standard skin rejuvenating treatment (0.1% retinol-based cream. Patients received treatment at weeks 0, 1, 2, and 3, and returned to the clinic at weeks 4, 8, and 12 for clinical assessments performed by an independent, blinded committee of physicians using subjective clinician assessment scales. Tolerability, adverse outcomes, and patient satisfaction were also assessed. Results: Analysis demonstrated that the KLOX LED light with KLOX placebo/base gel and the KLOX LED light + KLOX-001 gel formulation groups were superior to standard of

Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy

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Zhu, Liang [East Hospital, Tongji University School of Medicine, Shanghai (China); Dong, Chuanming [East Hospital, Tongji University School of Medicine, Shanghai (China); Department of Anatomy and Neurobiology, The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong (China); Sun, Chenxi; Ma, Rongjie; Yang, Danjing [East Hospital, Tongji University School of Medicine, Shanghai (China); Zhu, Hongwen, E-mail: hongwen_zhu@hotmail.com [Tianjin Hospital, Tianjin Academy of Integrative Medicine, Tianjin (China); Xu, Jun, E-mail: xunymc2000@yahoo.com [East Hospital, Tongji University School of Medicine, Shanghai (China)

2015-08-21

Aging of neural stem cell, which can affect brain homeostasis, may be caused by many cellular mechanisms. Autophagy dysfunction was found in aged and neurodegenerative brains. However, little is known about the relationship between autophagy and human neural stem cell (hNSC) aging. The present study used 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to treat neural precursor cells (NPCs) derived from human embryonic stem cell (hESC) line H9 and investigate related molecular mechanisms involved in this process. MPTP-treated NPCs were found to undergo premature senescence [determined by increased senescence-associated-β-galactosidase (SA-β-gal) activity, elevated intracellular reactive oxygen species level, and decreased proliferation] and were associated with impaired autophagy. Additionally, the cellular senescence phenotypes were manifested at the molecular level by a significant increase in p21 and p53 expression, a decrease in SOD2 expression, and a decrease in expression of some key autophagy-related genes such as Atg5, Atg7, Atg12, and Beclin 1. Furthermore, we found that the senescence-like phenotype of MPTP-treated hNPCs was rejuvenated through treatment with a well-known autophagy enhancer rapamycin, which was blocked by suppression of essential autophagy gene Beclin 1. Taken together, these findings reveal the critical role of autophagy in the process of hNSC aging, and this process can be reversed by activating autophagy. - Highlights: • We successfully establish hESC-derived neural precursor cells. • MPTP treatment induced senescence-like state in hESC-derived NPCs. • MPTP treatment induced impaired autophagy of hESC-derived NPCs. • MPTP-induced hESC-derived NPC senescence was rejuvenated by activating autophagy.

Mitochondrial rejuvenation after induced pluripotency.

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Steven T Suhr

2010-11-01

Full Text Available As stem cells of the early embryo mature and differentiate into all tissues, the mitochondrial complement undergoes dramatic functional improvement. Mitochondrial activity is low to minimize generation of DNA-damaging reactive oxygen species during pre-implantation development and increases following implantation and differentiation to meet higher metabolic demands. It has recently been reported that when the stem cell type known as induced pluripotent stem cells (IPSCs are re-differentiated for several weeks in vitro, the mitochondrial complement progressively re-acquires properties approximating input fibroblasts, suggesting that despite the observation that IPSC conversion "resets" some parameters of cellular aging such as telomere length, it may have little impact on other age-affected cellular systems such as mitochondria in IPSC-derived cells.We have examined the properties of mitochondria in two fibroblast lines, corresponding IPSCs, and fibroblasts re-derived from IPSCs using biochemical methods and electron microscopy, and found a dramatic improvement in the quality and function of the mitochondrial complement of the re-derived fibroblasts compared to input fibroblasts. This observation likely stems from two aspects of our experimental design: 1 that the input cell lines used were of advanced cellular age and contained an inefficient mitochondrial complement, and 2 the re-derived fibroblasts were produced using an extensive differentiation regimen that may more closely mimic the degree of growth and maturation found in a developing mammal.These results - coupled with earlier data from our laboratory - suggest that IPSC conversion not only resets the "biological clock", but can also rejuvenate the energetic capacity of derived cells.

Objective assessment of skin rejuvenation using near-infrared 1064-nm neodymium: YAG laser in Asians

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Tanaka Y

2011-07-01

Full Text Available Yohei Tanaka1,2, Kiyoshi Matsuo1, Shunsuke Yuzuriha11Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Japan; 2Clinica Tanaka Plastic and Reconstructive Surgery and Anti-aging Center, Matsumoto, JapanBackground: We reported previously that near-infrared (NIR irradiation provides long-lasting stimulation of elastin, and is efficient for skin rejuvenation. Many studies have indicated the efficacy of various types of laser, but did not include sufficiently objective evaluation. Therefore, we evaluated the efficacy of NIR laser treatment not only subjectively but also objectively.Methods: Fifty Japanese patients were treated with a NIR 1064-nm neodymium: YAG laser. Objective computer assessments were performed by Canfield VISIA Complexion Analysis for improvement of dilated pores, skin texture, and wrinkles. The volunteers then provided subjective assessments. Histological evaluations of elastin were performed by Victoria blue staining up to 90 days post-treatment in four Japanese volunteers.Results: Mean pretreatment percentiles of dilated pores, skin texture, and wrinkles were 51.08 ± 24.82, 54.7 ± 26.33, and 58.02 ± 28.61, respectively. Mean post-treatment percentiles of dilated pores, skin texture, and wrinkles were 53.58 ± 23.89, 58.58 ± 24.44, and 62.2 ± 25.39, respectively. All objective computer assessments evaluated by percentiles in dilated pores, skin texture, and wrinkles showed significant improvement after NIR laser treatment. Ninety-six percent, 100%, and 98% of volunteers reported satisfaction with the improvement of dilated pores, skin texture, and wrinkles, respectively. NIR laser treatment appeared to increase the amount of elastin at day 30, which then decreased slightly but was still elevated at day 90 compared with nonirradiated controls on day 0. Thickening of the epidermis was detected on day 30, and epidermal smoothness persisted for up to 90 days. No treatment

Vapocoolant Anesthesia for Cosmetic Facial Rejuvenation Injections: A Randomized, Prospective, Split-Face Trial.

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Zeiderman, Matthew R; Kelishadi, Shahrooz Sean; Tutela, John Paul; Rao, Arun; Chowdhry, Saeed; Brooks, Ronald M; Wilhelmi, Bradon J

2018-01-01

Background: Minimally invasive cosmetic procedures are the most commonly performed aesthetic techniques by plastic surgeons. Patients are interested in a pain-free experience. Surgeons desire patient satisfaction and time-efficient utilization of office staff and resources. Clinical evidence exists for use of vapocoolant technology to reduce pain associated with intravenous cannulation in the pediatric population and in hemodialysis patients. Applying vapocoolant technology to facial rejuvenation is a novel approach to decrease pain associated with neurotoxin or filler injection. Methods: A randomized, prospective study was conducted, testing 15 subjects receiving filler injections and another 15 patients receiving neurotoxin injections using a split-face model. The vapocoolant spray used was composed of a 95:5 ratio of 1,1,1,3,3-pentafluoropropane and 1,1,1,2-tetrafluoroethane. Within each group, individual patients randomly received injection (filler or neurotoxin) alone versus injection (filler or neurotoxin) plus vapocoolant on an equivalent half of his or her face. An independent examiner recorded from each patient on a scale of 1 to 10 perceived pain for injection alone versus injection plus vapocoolant spray. Results were calculated as a percentage change of pain scores experienced after injection for each person between the control (nonvapocoolant) and treatment (vapocoolant) sides of the face. Results: Vapocoolant spray at the time of cosmetic facial injections leads to a 59% decrease in perceived pain score with neurotoxin injections (range, 0%-100% change) and 64% decrease in perceived pain score with filler injections (range, 0%-100% change). These results were statistically significant with P reduces pain associated with facial rejuvenation procedures.

Low-Dose Fluvastatin and Valsartan Rejuvenate the Arterial Wall Through Telomerase Activity Increase in Middle-Aged Men.

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Janić, Miodrag; Lunder, Mojca; Cerkovnik, Petra; Prosenc Zmrzljak, Uršula; Novaković, Srdjan; Šabovič, Mišo

2016-04-01

Previously, we have shown that slightly to moderately aged arteries in middle-aged males can be rejuvenated functionally by sub-therapeutic, low-dose fluvastatin and valsartan treatment. Here, we explore whether this treatment could also increase telomerase activity. We hypothesized that telomerase activity might be associated with (1) an improvement of arterial wall properties and (2) a reduction of inflammatory/oxidative stress parameters (both observed in our previous studies). The stored blood samples from 130 apparently healthy middle-aged males treated with fluvastatin (10 mg daily), valsartan (20 mg daily), fluvastatin and valsartan combination (10 and 20 mg), respectively, and placebo (control), were analyzed. The samples were taken before and after treatment lasting 30 days, and 5 months after treatment discontinuation. Telomerase activity was measured in blood leukocytes by a TaqMan Gene Expression Assay. Low-dose fluvastatin or valsartan increased telomerase activity (106.9% and 59.5% respectively; both p valsartan substantially increased telomerase activity, which significantly correlated with an improvement of endothelial function and a decrease of inflammation/oxidative stress. These findings could lead to a new innovative approach to arterial rejuvenation.

Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation: Clinical, Instrumental, and Flow Cytometry Assessment.

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Cameli, Norma; Mariano, Maria; Cordone, Iole; Abril, Elva; Masi, Serena; Foddai, Maria Laura

2017-06-01

Platelet-rich plasma (PRP) is an emerging treatment in dermatology recently proposed for skin rejuvenation. To evaluate the efficacy and safety of autologous pure PRP dermal injections on facial skin rejuvenation, investigating the cellularity of PRP samples. Twelve patients underwent 3 sessions of PRP injection at 1-month intervals. The clinical and instrumental outcomes were evaluated before (T0) and 1 month (T1) after the end of treatment by means of transepidermal water loss, corneometry, Cutometer, Visioscan, and Visioface. A flow cytometry characterization on PRP and peripheral blood (PB) samples was performed. Clinical and patient evaluation showed improvement of skin texture. Skin gross elasticity, skin smoothness parameters, skin barrier function, and capacitance were significantly improved. No difference between PRP and PB lymphocyte immunological asset was observed. A leukocyte population (mainly CD3) and neutrophils depletion were documented in all the PRP samples. This instrumental study demonstrated that PRP poor in leukocytes can provide objective improvements in skin biostimulation. Flow cytometry showed no variability among the PRP samples using a reproducible separation system and a low content in proinflammatory cells. Although a pilot study, it may be helpful for future investigations on PRP cellularity.

Aging and rejuvenation of active matter under topological constraints.

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Janssen, Liesbeth M C; Kaiser, Andreas; Löwen, Hartmut

2017-07-18

The coupling of active, self-motile particles to topological constraints can give rise to novel non-equilibrium dynamical patterns that lack any passive counterpart. Here we study the behavior of self-propelled rods confined to a compact spherical manifold by means of Brownian dynamics simulations. We establish the state diagram and find that short active rods at sufficiently high density exhibit a glass transition toward a disordered state characterized by persistent self-spinning motion. By periodically melting and revitrifying the spherical spinning glass, we observe clear signatures of time-dependent aging and rejuvenation physics. We quantify the crucial role of activity in these non-equilibrium processes, and rationalize the aging dynamics in terms of an absorbing-state transition toward a more stable active glassy state. Our results demonstrate both how concepts of passive glass phenomenology can carry over into the realm of active matter, and how topology can enrich the collective spatiotemporal dynamics in inherently non-equilibrium systems.

Latest laser and light-based advances for ethnic skin rejuvenation

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Elsaie Mohamed

2008-01-01

Full Text Available Background: Advances in nonablative skin rejuvenation technologies have sparked a renewed interest in the cosmetic treatment of aging skin. More options exist now than ever before to reverse cutaneous changes caused by long-term exposure to sunlight. Although Caucasian skin is more prone to ultraviolet light injury, ethnic skin (typically classified as types IV to VI also exhibits characteristic photoaging changes. Widespread belief that inevitable or irreversible textural changes or dyspigmentation occurs following laser- or light-based treatments, has been challenged in recent years by new classes of devices capable of protecting the epidermis from injury during treatment. Objective: The purpose of this article is to review recent clinical advances in the treatment of photoaging changes in ethnic skin. This article provides a basis for the classification of current advances in nonablative management of ethnic skin.

Towards cultural materialism in the medical humanities: the case of blood rejuvenation.

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Oakley, Catherine

2018-03-01

This paper argues for an approach within the medical humanities that draws on the theoretical legacy of cultural materialism as a framework for reading cultural practices and their relationship to the social and economic order. It revisits the origins and development of cultural materialism in cultural studies and literary studies between the 1970s and 1990s and considers how, with adaptation, this methodology might facilitate ideological criticism focused on material formations of health, disease and the human body. I outline three key characteristics of a medicocultural materialist approach along these lines: (a) interdisciplinary work on a broad range of medical and cultural sources, including those drawn from 'popular' forms of culture; (b) the combination of historicist analysis with scrutiny of present-day contexts; (c) analyses that engage with political economy perspectives and/or the work of medical sociology in this area. The subsequent sections of the paper employ a medicocultural materialist approach to examine conjectural understandings of, and empirical investigations into, the capacity of transfused human blood to rejuvenate the ageing body. I trace textual faultlines that expose the structures of power which inform the movement of blood between bodies in 'medical gothic' fictions from the 19th-century fin de siècle, including Mary Elizabeth Braddon's 'Good Lady Ducayne' (1896) and Bram Stoker's Dracula (1897). I conclude with a critique of biomedical innovations in blood rejuvenation in the era of medical neoliberalism, before considering the potential applications of medicocultural materialism to other topics within the field of the medical humanities. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

[Is it possible to rejuvenate the aging global civilization?

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Makrushin, A V; Aladin, N V; Vasiliev, A S

2017-01-01

Society is not only social system but also biological system. Growing complexity of biological systems will inevitably lead to the loss of their potential immortality and to the appeared attribute of aging. The aging of the present-day civilization is evidenced by the problems having accumulated. The answer to the question concerning the possibility to prevent collapse depends on the answer to the more general question - whether supra-organismal system that due to the growth of the structure complexity has acquired the property to age without losing achieved complexity can return to ancestral potential immortality. A positive response is given to this question. Supra-organismal systems having been freed from the necessity to age exist. Those are communities of social insects. Some of them were mortal initially but in the course of evolution have lost attribute of aging. Therefore, complex supra-organismal systems, including present-day civilization, can return to ancestral potential immortality not losing the achieved structural complexity. The main obstacle to rejuvenating civilization is not the nature of things but the human mentality.

Perioral Rejuvenation With Ablative Erbium Resurfacing.

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Cohen, Joel L

2015-11-01

Since the introduction of the scanning full-field erbium laser, misconceptions regarding ablative erbium resurfacing have resulted in its being largely overshadowed by ablative fractional resurfacing. This case report illustrates the appropriateness of full-field erbium ablation for perioral resurfacing. A patient with profoundly severe perioral photodamage etched-in lines underwent full-field ablative perioral resurfacing with an erbium laser (Contour TRL, Sciton Inc., Palo Alto, CA) that allows separate control of ablation and coagulation. The pre-procedure consultations included evaluation of the severity of etched-in lines, and discussion of patient goals, expectations, and appropriate treatment options, as well as a review of patient photos and post-treatment care required. The author generally avoids full-field erbium ablation in patients with Fitzpatrick type IV and above. For each of 2 treatment sessions (separated by approximately 4 months), the patient received (12 cc plain 2% lidodaine) sulcus blocks before undergoing 4 passes with the erbium laser at 150 μ ablation, no coagulation, and then some very focal 30 μ ablation to areas of residual lines still visualized through the pinpoint bleeding. Similarly, full-field ablative resurfacing can be very reliable for significant wrinkles and creping in the lower eyelid skin--where often a single treatment of 80 μ ablation, 50 μ coagulation can lead to a nice improvement. Standardized digital imaging revealed significant improvement in deeply etched rhytides without significant adverse events. For appropriately selected patients requiring perioral (or periorbital) rejuvenation, full-field ablative erbium resurfacing is safe, efficacious and merits consideration.

Radiofrequency facial rejuvenation: evidence-based effect.

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el-Domyati, Moetaz; el-Ammawi, Tarek S; Medhat, Walid; Moawad, Osama; Brennan, Donna; Mahoney, My G; Uitto, Jouni

2011-03-01

Multiple therapies involving ablative and nonablative techniques have been developed for rejuvenation of photodamaged skin. Monopolar radiofrequency (RF) is emerging as a gentler, nonablative skin-tightening device that delivers uniform heat to the dermis at a controlled depth. We evaluated the clinical effects and objectively quantified the histologic changes of the nonablative RF device in the treatment of photoaging. Six individuals of Fitzpatrick skin type III to IV and Glogau class I to II wrinkles were subjected to 3 months of treatment (6 sessions at 2-week intervals). Standard photographs and skin biopsy specimens were obtained at baseline, and at 3 and 6 months after the start of treatment. We performed quantitative evaluation of total elastin, collagen types I and III, and newly synthesized collagen using computerized histometric and immunohistochemical techniques. Blinded photographs were independently scored for wrinkle improvement. RF produced noticeable clinical results, with high satisfaction and corresponding facial skin improvement. Compared with the baseline, there was a statistically significant increase in the mean of collagen types I and III, and newly synthesized collagen, while the mean of total elastin was significantly decreased, at the end of treatment and 3 months posttreatment. A limitation of this study is the small number of patients, yet the results show a significant improvement. Although the results may not be as impressive as those obtained by ablative treatments, RF is a promising treatment option for photoaging with fewer side effects and downtime. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

[Body experience and self-esteem after minimally invasive skin rejuvenation : Study of female patients using botulinum toxin A and/or dermal fillers].

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Scharschmidt, D; Preiß, S; Brähler, E; Fischer, T; Borkenhagen, A

2017-12-01

More and more people worldwide and also in Germany are using botulinum toxin type A (BoNT-A) and hyaluronic acid injections for skin rejuvenation. Study on body image and self-esteem of women with BoNT-A and/or hyaluronic acid filler treatment. A total of 145 women who requested BoNT-A and/or hyaluronic acid injections completed a survey comprised of the body dysmorphic disorder questionnaire, the Rosenberg self-esteem scale and questionnaires on the attitudes and motives on measures for optimization of the body and demographic features. Using this instrument data on the body image and self-esteem as well as attitudes and motives for utilization of minimally invasive skin rejuvenation were collated. Female users of minimally invasive skin rejuvenation showed an overall higher socioeconomic status and an above average high monthly income. They lived in a partnership more often in comparison to women of equal age living in Berlin. The users of BoNT-A and/or hyaluronic acid fillers showed no conspicuous differences in body image and self-esteem. They showed a moderately positive attitude to body optimization procedures and 91% achieved their standard weight with a body mass index (BMI) of ≤25 kg/m 2 in comparison to 56% of German women in the same age range (25 to ≥75 years old). In the first study of body image and self-esteem in users of BoNT‑A and/or dermal fillers in German women, the users showed no signs of body dysmorphic patterns or disorders of self-esteem.

The comparison of skin rejuvenation effects of vitamin A, fractional laser, and their combination on rat.

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Qu, Yan; Wang, Ying; Zhang, Yan; Han, Chunyu; Gao, Dong; Jin, Waishu; Liang, Jinning; Xia, Xiujuan

2018-03-15

Because of long-term exposure of skin, skin aging is an unavoidable natural law with age. Traditional Vitamin A and novel ablative fractional laser technique both have the effects of skin rejuvenation, and studies have demonstrated both of them have apparent clinical efficacy and histology-improving effects on photo-aging skin. 45 female healthy Wistar rats were selected and the depilation areas of every rat were divided into four regions: control region(Region A), Vitamin A acid region(Region B), combination treatment region(Region C), and fractional laser region(Region D). 0.025% Vitamin A acid cream was applied to Region B and C every day for 3 weeks; Region C and D were irradiated once with 10600nm CO 2 fractional laser on the first day of the trail. The skin tissue was dissected and placed into liquid nitrogen according to the design. The real-time quantitative PCR and western blotting methods were taken to detect the expression changes of miR-29a, Akt, TGF-β, and mRNA of type III pre-collagen. It can be seen from the results of the real-time quantitative PCR that the mRNA expression levels of type III pre-collagen, Akt, and TGF-β in the treatment regions are up-regulated and the expression levels of miR-29a mRNA are down-regulated compared to the Region A. The hybridization tests showed that changes of the expression of type III pre-collagen, Akt gene, miR-29a gene, and TGF-β gene across the experiment regions are all significantly different in the third week, and the expression levels of them all achieve the highest value in the third week, the expression level of miR-29a gene achieves the lowest value in the third week, which are consistent with the results of real-time quantitative PCR. It is indicated that the combination region of Vitamin A acid and fractional laser may lead to low expression of miR-29a, thus the inhibition of downstream Akt activation is loss, Akt activation is enhanced, enhancement of the expression of TGF-β is induced, leading to

Rejuvenation of the Innocent Bystander: Testing Spin-Up in Dwarf Carbon Stars

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Green, Paul

2013-09-01

Carbon stars (C>O) were long assumed to all be giants, because only AGB stars dredge up significant carbon into their atmospheres. We now know that dwarf carbon (dC) stars are actually far more common than C giants. These dCs are hypothesized to have accreted C-rich envelope material from an AGB companion, in systems that have likely undergone a planetary nebula phase, eventually yielding a white dwarf and a dC that has gained both significant mass and angular momentum. To test whether the X-ray emission strength and spectral properties are consistent with a rejuvenated dynamo, we propose a Chandra pilot study of dCs selected from the SDSS; some have hot white dwarf companions (indicating more recent mass transfer), and all show Balmer emission lines (a sign of activity).

Ascorbate-dependent impact on cell-derived matrix in modulation of stiffness and rejuvenation of infrapatellar fat derived stem cells toward chondrogenesis.

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Pizzute, Tyler; Zhang, Ying; He, Fan; Pei, Ming

2016-08-10

Developing an in vitro microenvironment using cell-derived decellularized extracellular matrix (dECM) is a promising approach to efficiently expand adult stem cells for cartilage engineering and regeneration. Ascorbic acid serves as a critical stimulus for cells to synthesize collagens, which constitute the major component of dECM. In this study, we hypothesized that optimization of ascorbate treatment would maximize the rejuvenation effect of dECM on expanded stem cells from human infrapatellar fat pad in both proliferation and chondrogenic differentiation. In the duration regimen study, we found that dECM without L-ascorbic acid phosphate (AA) treatment, exhibiting lower stiffness measured by atomic force microscopy, yielded expanded cells with higher proliferation capacity but lower chondrogenic potential when compared to those with varied durations of AA treatment. dECM with 250 µM of AA treatment for 10 d had better rejuvenation in chondrogenic capacity if the deposited cells were from passage 2 rather than passage 5, despite no significant difference in matrix stiffness. In the dose regimen study, we found that dECMs deposited by varied concentrations of AA yielded expanded cells with higher proliferation capacity despite lower expression levels of stem cell related surface markers. Compared to cells expanded on tissue culture polystyrene, those on dECM exhibited greater chondrogenic potential, particularly for the dECMs with 50 µM and 250 µM of AA treatment. With the supplementation of ethyl-3,4-dihydroxybenzoate (EDHB), an inhibitor targeting procollagen synthesis, the dECM with 50 µM of AA treatment exhibited a dramatic decrease in the rejuvenation effect of expanded cell chondrogenic potential at both mRNA and protein levels despite no significant difference in matrix stiffness. Defined AA treatments during matrix preparation will benefit dECM-mediated stem cell engineering and future treatments for cartilage defects.

Calcium hydroxylapatite for jawline rejuvenation: consensus recommendations.

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Dallara, Jean-Marie; Baspeyras, Martine; Bui, Patrick; Cartier, Hugues; Charavel, Marie-Hélène; Dumas, Laurent

2014-03-01

Age-associated volume loss is now known to play an important role in the structural changes of the aging face. In the lower face, this manifests as drooping of the corners of the mouth and jowl leading to a loss of the oval jawline of youth. Jawline reshaping by replacing volume has therefore become an indispensable component of modern facial rejuvenation. Calcium hydroxylapatite (CaHA; Radiesse® , Merz Pharmaceuticals GmbH, Frankfurt, Germany) is an injectable filler with a cosmetic indication for tissue augmentation. The ability of calcium hydroxylapatite to provide immediate and long-lasting volume enhancement makes it an ideal agent for restoring an oval jawline. This consensus statement has been developed to assist clinicians who would like to gain more experience in the use of volumizing agents to achieve an optimal outcome with this procedure. Using the recently developed Merz Aesthetics Scale® for jawline, the consensus provides a treatment protocol for individuals at each stage of oval loss and presents a series of before and after images to illustrate the improvements that can be achieved. Specific recommendations for calcium hydroxylapatite including type of anesthesia, injection techniques, volume for injection, use in combination with other procedures, and expected duration of corrections are provided. Techniques for minimizing and managing expected problems and potential complications are also described. Calcium hydroxylapatite is appropriate for treating patients at any stage of oval loss. © 2014 Wiley Periodicals, Inc.

Calorie Restriction, Stem Cells, and Rejuvenation Approach

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Taufiqurrachman Nasihun

2017-03-01

Full Text Available Aging may be defined as the time-dependent deterioration in function of an organism associated with or responsible for the increase in susceptibility to disease and probability of death with advancing age (Harman, 1981; Cefalu, 2011. Generally, the aging organisms are characterized by both biochemical and functional declines. Declining of basal metabolism rates, protein turnover, glucose tolerance, reproductive capacity, telomere shortening, and oxidative phosphorylation are related to the biochemical. Whilst, lung expansion volume, renal glomerular and tubular capacities, cardiovascular performance, musculoskeletal system, nerve conduction velocity, endocrine and exocrine systems, immunological defenses, and sensory systems are associated with the physiological declining (Baynes and Dominiczak, 2015. Some evidences indicated that, although members of a species develop into adults in the same way, even genetically similar or identical individuals, raised in identical conditions and eating identical food, but they may age differently (Baynes and Dominiczak, 2015. These aging differences are attributable to the life style particularly calorie and dietary restriction intakes, reactive oxygen species (ROS production, and thus its implication on severity of damage, repair capacity, and error accumulation in cellular genetic material (Baynes and Dominiczak, 2015; Mihaylova et al., 2014; Mazzoccoli et al., 2014. Therefore, in molecular terms, aging can be defined as a decline of the homeostatic mechanisms that ensure the function of cells, tissues, and organs systems (Mazzoccoli et al., 2014. Accordingly, if the homeostatic mechanism can be repaired, the result is rejuvenation.

Discrimination of the Thai rejuvenating herbs Pueraria candollei (White Kwao Khruea), Butea superba (Red Kwao Khruea), and Mucuna collettii (Black Kwao Khruea) using PCR-RFLP.

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Wiriyakarun, Suchaya; Yodpetch, Woraluk; Komatsu, Katsuko; Zhu, Shu; Ruangrungsi, Nijsiri; Sukrong, Suchada

2013-07-01

The tuberous roots of Pueraria candollei (White Kwao Khruea), Butea superba (Red Kwao Khruea) and Mucuna collettii (Black Kwao Khruea), which belong to the family Leguminosae, are used as rejuvenating herbs in traditional Thai medicine. Although all of these species have an indication for rejuvenation, each differs in its medicinal properties. Two varieties of P. candollei, var. mirifica and var. candollei, affect females, whereas B. superba and M. collettii exhibit effects on males. However, the identification of these roots according to the name "Kwao Khruea" is confusing due to the similarity in their features. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was utilised to identify plant origin. The partial matK gene was amplified and subjected to restriction enzyme digestion with DdeI and TaqI. The restriction fragments generated differed in number and size. To test the reliability of the method, an admixture of the different Kwao Khruea species containing equal amounts of DNA was tested. The results showed combined restriction patterns, and each species could be detected in the background of the others. The method was also used to authenticate eight different crude drugs sold as various types of Kwao Khruea in Thai markets. The results showed that the misidentification of commercial drugs remains a problem in crude drug markets. The PCR-RFLP analysis developed here provides a simple and accurate discrimination of these rejuvenating "Kwao Khruea" species.

Fractional CO2 laser treatment for vulvovaginal atrophy symptoms and vaginal rejuvenation in perimenopausal women

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Arroyo C

2017-08-01

Full Text Available César Arroyo HM Montepríncipe University Hospital Laser Unit, Madrid, Spain Background: This study investigated a novel fractional carbon dioxide (CO2 laser for treatment of symptoms associated with vulvovaginal atrophy (VVA in perimenopausal women.Methods: The study included 21 perimenopausal women (mean age 45±7 years treated three times by CO2 laser resurfacing and coagulation of the vaginal canal tissue and mucosal tissue of the introitus. Vaginal health index (VHI scores were computed by the investigator at baseline and follow-ups. Subjects reported on sexual function, satisfaction, and improvement with treatment. A visual analog scale was used to measure discomfort with treatment.Results: Vaginal health and subject assessment of vaginal symptoms improved with successive treatments. At 12 weeks following the third treatment, 82% of the patients showed a statistically significant improvement in VHI (P<0.05. Additionally, 81% of subjects reported improvement in sexual gratification, 94% reported improvement in vaginal rejuvenation, and 100% reported satisfaction with treatment. VHI improvement remained significant at 6–8 months after treatments (P<0.01. Most patients (97% reported no to mild discomfort with treatment. Responses were mild and transient following treatment, with itching being the most commonly reported (20% side effect.Conclusion: In this study, fractional CO2 laser treatment was associated with improvement of vaginal health and amelioration of symptoms of VVA, resulting in improved sexual function in perimenopausal women. Treatment time was quick, and there was minimal discomfort associated with treatment. Investigation of clinical outcome in a larger study population is warranted. Keywords: genitourinary syndrome of menopause, vaginal rejuvenation, stress urinary incontinence, collagen remodeling, sexual dysfunction, vulvovaginal atrophy

Gross and microscopic findings in patients undergoing microdermabrasion for facial rejuvenation.

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Hernandez-Perez, E; Ibiett, E V

2001-07-01

Microdermabrasion (MDA) is a new procedure used for the treatment of cosmetic problems, particularly to combat photoaging and intrinsic aging. Though excellent clinical improvement has been well documented, histologic support is limited. To determine if microscopic changes correlate with clinical improvement and to examine the depth of penetration compared to chemical peels. Seven women were submitted to five MDA sessions at weekly intervals. Skin biopsies were performed in all of them, before and after the treatment. Clinical and photographic assessments were recorded weekly. Data concerning skin features, including oiliness, thickness, dilated pores, and general appearance, were all assessed. Microscopic improvement of changes associated with cutaneous aging in the epidermis and dermis where all assessed. For statistical analysis, a t-test for small samples was utilized. All the patients showed clinical and microscopic improvement in all of the parameters assessed. The t-test for small samples showed a P <.05. MDA is a good alternative for facial rejuvenation. Improvements in both clinical and microscopic parameters are readily demonstrable.

Intense pulsed light, near infrared pulsed light, and fractional laser combination therapy for skin rejuvenation in Asian subjects: a prospective multi-center study in China.

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Tao, Li; Wu, Jiaqiang; Qian, Hui; Lu, Zhong; Li, Yuanhong; Wang, Weizhen; Zhao, Xiaozhong; Tu, Ping; Yin, Rui; Xiang, Leihong

2015-09-01

Ablative skin rejuvenation therapies have limitations for Asian people, including post-inflammatory hyperpigmentation and long down time. Non-ablative lasers are safer but have limited efficacy. This study is to investigate the safety and efficacy of a combination therapy consisting of intense pulsed light (IPL), near infrared (NIR) light, and fractional erbium YAG (Er:YAG) laser for skin rejuvenation in Asian people. This study recruited 113 subjects from six sites in China. Subjects were randomly assigned to a full-face group, who received combination therapy, and split-face groups, in which one half of the face received combination therapy and the other half received IPL monotherapy. Each subject received five treatment sessions during a period of 90 days. Subjects were followed up at 1 and 3 months post last treatment. Three months after last treatment, the full-face group (n = 57) had a global improvement rate of 29 % and 29 % for wrinkles, 32 % for skin texture, 33 % for pigment spots, 28 % for pore size, respectively. For patients in the split-face groups (n = 54), monotherapy side had a global improvement rate of 23 % and 20 % for wrinkles, 27 % for skin texture, 25 % for pigment spots, 25 % for pore size, respectively. Both combination therapy and monotherapy resulted in significant improvements at the follow-up visits compared to baseline (P < 0.001). Combination therapy showed significantly greater improvements compared to monotherapy at two follow-up visits (P < 0.05). Combination therapy is a safe and more effective strategy than IPL monotherapy for skin rejuvenation in Asian people.

Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria.

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Agrawal, Anurag; Mabalirajan, Ulaganathan

2016-01-15

Altered bioenergetics with increased mitochondrial reactive oxygen species production and degradation of epithelial function are key aspects of pathogenesis in asthma and chronic obstructive pulmonary disease (COPD). This motif is not unique to obstructive airway disease, reported in related airway diseases such as bronchopulmonary dysplasia and parenchymal diseases such as pulmonary fibrosis. Similarly, mitochondrial dysfunction in vascular endothelium or skeletal muscles contributes to the development of pulmonary hypertension and systemic manifestations of lung disease. In experimental models of COPD or asthma, the use of mitochondria-targeted antioxidants, such as MitoQ, has substantially improved mitochondrial health and restored respiratory function. Modulation of noncoding RNA or protein regulators of mitochondrial biogenesis, dynamics, or degradation has been found to be effective in models of fibrosis, emphysema, asthma, and pulmonary hypertension. Transfer of healthy mitochondria to epithelial cells has been associated with remarkable therapeutic efficacy in models of acute lung injury and asthma. Together, these form a 3R model--repair, reprogramming, and replacement--for mitochondria-targeted therapies in lung disease. This review highlights the key role of mitochondrial function in lung health and disease, with a focus on asthma and COPD, and provides an overview of mitochondria-targeted strategies for rejuvenating cellular respiration and optimizing respiratory function in lung diseases. Copyright © 2016 the American Physiological Society.

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature.

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Sclafani, Anthony P; Azzi, James

2015-08-01

In facial plastic surgery, the potential for direct delivery of growth factors from platelet preparations has been of particular interest for use in facial rejuvenation, recovery after facial surgery, and wound healing. A literature search was conducted through PubMed for the terms PRP, PRFM, platelet-rich plasma, platelet-rich fibrin matrix, platelet preparations, platelet therapy, growth factors, platelet facial, platelet facial rejuvenation, platelet wound healing, platelet plastic surgery. Articles pertaining to the use of platelet preparations in facial surgery and wound healing in plastic surgery after 2001 were included. Thirteen in vitro studies showed use of platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM) had a significant effect on cellular activity. Twenty-four out of 28 animal studies exhibited favorable results with use of a platelet preparation, including five of six studies that showed enhanced fat graft survival with addition of a platelet preparation. Twenty-three case series and clinical trials were identified, only two of which showed no differences. Twenty-one reported favorable results with use of various platelet preparations. A total of 47 studies used PRP, four studies evaluated Leukocyte-rich PRP, and fourteen studies used PRFM. The vast majority of studies examined show a significant and measurable effect on cellular changes, wound healing, and facial esthetic outcomes with use of platelet preparations, both topical and injectable. One must also consider possible publication bias against null results that may have had an influence on the data that were available for review. However, the preponderance of studies suggests that platelet preparations might represent an as-of-yet untapped adjunct in facial plastic surgery.

Under eye infraorbital injection technique: the best value in facial rejuvenation.

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Shetty, Rashmi

2014-03-01

The use of fillers in esthetic rejuvenation or reshaping has been well established and is one of toughest techniques for beginners due to segmental attachments and proximity to important anatomical structures in the infraorbital area making it difficult to achieve smooth esthetic results. To make filling easy, smooth, and repeatable, anatomical points were marked through specific surface measurements. Patients were injected with 0.5-1 mL of hyaluronic acid filler using the identified anatomical point. All patients treated have achieved restoration of the ogee curve with no bruising and minimal downtime with results lasting for 12-36 months. The results of the study suggest the use of single repeatable injection at the crucial point and if required at multiple identified anatomical points along the ligamental attachment to satisfy the esthetic outcome of the patient. Injection of filler at infraorbital points could instantly lift the face up, elevating the point of shadow and shifting the point of highest light reflection to the ideal malar point. © 2014 Wiley Periodicals, Inc.

The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CO2 Laser Therapy for Facial Rejuvenation.

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Hui, Qiang; Chang, Peng; Guo, Bingyu; Zhang, Yu; Tao, Kai

2017-02-01

Ultra-pulsed fractional CO 2 laser is an efficient, precise, and safe therapeutic intervention for skin refreshing, although accompanied with prolonged edema and erythema. In recent years, autologous platelet-rich plasma (PRP) has been proven to promote wound and soft tissue healing and collagen regeneration. To investigate whether the combination of PRP and ultra-pulsed fractional CO 2 laser had a synergistic effect on therapy for facial rejuvenation. Totally, 13 facial aging females were treated with ultra-pulsed fractional CO 2 laser. One side of the face was randomly selected as experimental group and injected with PRP, the other side acted as the control group and was injected with physiological saline at the same dose. Comprehensive assessment of clinical efficacy was performed by satisfaction scores, dermatologists' double-blind evaluation and the VISIA skin analysis system. After treatment for 3 months, subjective scores of facial wrinkles, skin texture, and skin elasticity were higher than that in the control group. Similarly, improvement of skin wrinkles, texture, and tightness in the experimental group was better compared with the control group. Additionally, the total duration of erythema, edema, and crusting was decreased, in the experimental group compared with the control group. PRP combined with ultra-pulsed fractional CO 2 laser had a synergistic effect on facial rejuvenation, shortening duration of side effects, and promoting better therapeutic effect.

Use of platelet-rich fibrin as an autologous biologic rejuvenating media for avulsed teeth - an in vitro study.

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Hiremath, Hemalatha; Kulkarni, Sadanand; Sharma, Robin; Hiremath, Vishwanath; Motiwala, Tejas

2014-12-01

The prognosis of replanted avulsed tooth depends on the existence of viable cells in the periodontal ligament and also on those cells which are able to proliferate on the damaged areas of the root. The purpose of this study was to evaluate the survival of periodontal ligament cells (PDL) when soaked in an autologous biologic rejuvenating media after an extra-oral dry time of 40 min. Thirty teeth were selected with intact crown which were advised for Orthodontic extraction having healthy PDL. They were divided into two experimental and two control groups. The positive and negative controls corresponded to 0-min and 1-h dry time, respectively. The experimental teeth were stored dry for 40 min and then immersed in one of the two media, combination of platelet-rich fibrin and platelet poor plasma (PRF+PPP) and PPP for 45 min. The teeth in each group were treated with dispase II and collagenase for 30 min and later centrifuged for 5 min at 50.17 g. The supernatant was removed with sterile micropipette, the cells labelled with 0.4% trypan blue, and the number of viable PDL cells was counted with a haemocytometer, under a light microscope. anova and Mann-Whitney U-test demonstrated statistically significant differences in the viability of PDL cells among experimental groups. Within the parameters of this study, a combination of platelet-rich fibrin and PPP demonstrated higher number of viable PDL cells and hence could be a good biologic rejuvenating media for avulsed teeth. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Rejuvenation of the Innocent Bystander: Testing Spin-Up in a Dwarf Carbon Star Sample

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Green, Paul

2014-09-01

Carbon stars (C>O) were long assumed to all be giants, because only AGB stars dredge up significant carbon into their atmospheres. We now know that dwarf carbon (dC) stars are actually far more common than C giants. These dC stars are hypothesized to have accreted C-rich envelope material from an AGB companion, in systems that have likely undergone a planetary nebula phase, eventually yielding a white dwarf and a dC star that has gained both significant mass and angular momentum. To test whether the X-ray emission strength and spectral properties are consistent with a rejuvenated dynamo, we propose a Chandra pilot study of dCs selected from the SDSS; some have hot white dwarf companions (indicating more recent mass transfer), and all show Balmer emission lines (a sign of activity).

Shallow system rejuvenation and magma discharge trends at Piton de la Fournaise volcano (La Réunion Island)

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Coppola, D.; Di Muro, A.; Peltier, A.; Villeneuve, N.; Ferrazzini, V.; Favalli, M.; Bachèlery, P.; Gurioli, L.; Harris, A. J. L.; Moune, S.; Vlastélic, I.; Galle, B.; Arellano, S.; Aiuppa, A.

2017-04-01

Basaltic magma chambers are often characterized by emptying and refilling cycles that influence their evolution in space and time, and the associated eruptive activity. During April 2007, the largest historical eruption of Piton de la Fournaise (Île de La Réunion, France) drained the shallow plumbing system (> 240 ×106 m3) and resulted in collapse of the 1-km-wide summit crater. Following these major events, Piton de la Fournaise entered a seven-year long period of near-continuous deflation interrupted, in June 2014, by a new phase of significant inflation. By integrating multiple datasets (lava discharge rates, deformation, seismicity, gas flux, gas composition, and lava chemistry), we here show that the progressive migration of magma from a deeper (below sea level) storage zone gradually rejuvenated and pressurized the above-sea-level portion of the magmatic system consisting of a vertically-zoned network of relatively small-volume magma pockets. Continuous inflation provoked four small (CO2 enrichment of summit fumaroles, and involving emission of less differentiated lavas, to end with, (iii) three short-lived (∼2 day-long) pulses in lava and gas flux, coupled with arrival of cumulative olivine at the surface and deflation. The activity observed at Piton de la Fournaise in 2014 and 2015 points to a new model of shallow system rejuvenation and discharge, whereby continuous magma supply causes eruptions from increasingly deeper and larger magma storage zones. Downward depressurization continues until unloading of the deepest, least differentiated magma triggers pulses in lava and gas flux, accompanied by rapid contraction of the volcano edifice, that empties the main shallow reservoir and terminates the cycle. Such an unloading process may characterize the evolution of shallow magmatic systems at other persistently active effusive centers.

Impact of excessive groundwater pumping on rejuvenation processes in the Bandung basin (Indonesia) as determined by hydrogeochemistry and modeling

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Taufiq, Ahmad; Hosono, Takahiro; Ide, Kiyoshi; Kagabu, Makoto; Iskandar, Irwan; Effendi, Agus J.; Hutasoit, Lambok M.; Shimada, Jun

2017-12-01

In the Bandung basin, Indonesia, excessive groundwater pumping caused by rapid increases in industrialization and population growth has caused subsurface environmental problems, such as excessive groundwater drawdown and land subsidence. In this study, multiple hydrogeochemical techniques and numerical modeling have been applied to evaluate the recharge processes and groundwater age (rejuvenation). Although all the groundwater in the Bandung basin is recharged at the same elevation at the periphery of the basin, the water type and residence time of the shallow and deep groundwater could be clearly differentiated. However, there was significant groundwater drawdown in all the depression areas and there is evidence of groundwater mixing between the shallow and deep groundwater. The groundwater mixing was traced from the high dichlorodifluoromethane (CFC-12) concentrations in some deep groundwater samples and by estimating the rejuvenation ratio (R) in some representative observation wells. The magnitude of CFC-12 concentration, as an indicator of young groundwater, showed a good correlation with R, determined using 14C activity in samples taken between 2008 and 2012. These correlations were confirmed with the estimation of vertical downward flux from shallower to deeper aquifers using numerical modeling. Furthermore, the change in vertical flux is affected by the change in groundwater pumping. Since the 1970s, the vertical flux increased significantly and reached approximately 15% of the total pumping amount during the 2000s, as it compensated the groundwater pumping. This study clearly revealed the processes of groundwater impact caused by excessive groundwater pumping using a combination of hydrogeochemical methods and modeling.

The clinical effectiveness and cost-effectiveness of fractional CO2 laser in acne scars and skin rejuvenation: A meta-analysis and economic evaluation.

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Ansari, Fereshteh; Sadeghi-Ghyassi, Fatemeh; Yaaghoobian, Barmak

2018-01-31

Fractional CO 2 has many indications in medicine including in treatment of acne scars and rejuvenation. The aim of this study was to evaluate the safety, efficacy, and cost-effectiveness of Fractional CO 2 Laser in comparison with other methods of rejuvenation and acne scar treatment. Several databases including Medline, OVID, EMBASE, CINHAL, SCOPUS, Web of science, CRD, and Cochrane were searched. After conducting the search and evaluation of selected publications, critical appraisal was done and eligible studies were accepted for inclusion in the systematic review. From 2667 identified publications two of the trials were eligible. The effectiveness and complications of Fractional CO 2 laser were comparable with Er:YAG but Fractional CO 2 laser was 14.7% (p = 0.01) more effective than Q-Switched ND:YAG laser. Cost affectivity of this method was the same as other alternative lasers. In conclusion Fractional CO 2 laser is an effective and safe method for curing of several kinds of skin diseases. Nevertheless there was not sufficient evidence to support its advantage. This device has equal or lower price in comparison to competent technologies except for the non- fractional ablative CO 2 laser that has the same or lower price and comparable effects.

Rejuvenating direct modulation and direct detection for modern optical communications

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Che, Di; Li, An; Chen, Xi; Hu, Qian; Shieh, William

2018-02-01

High-speed transoceanic optical fiber transmission using direct modulation (DM) and direct detection (DD) was one of the most stirring breakthroughs for telecommunication in 1990s, which drove the internet as a global phenomenon. However, the later evolution of optical coherent communications in 2000s gradually took over the long-haul applications, due to its superior optical spectral efficiency. Nowadays, DM-DD systems are dominant mainly in cost- and power-sensitive short-reach applications, because of its natural characteristics-the simplicity. This paper reviews the recent advances of DM-DD transceivers from both hardware and signal processing perspectives. It introduces a variety of modified DM and/or DD systems for 3 application scenarios: very-short-reach interconnect with little fiber channel impact; single or a few spans of fiber transmission up to several hundred km; and distance beyond the 2nd scenario. Besides the DM-DD and multi-dimension DM-DD with polarization diversity, this paper focuses on how to rejuvenate traditional DM and DD technologies in order to bridge the transmission application gap between DM-DD and coherent transceivers, using technologies such as dispersion compensation, signal field recovery from the intensity-only DD receiver, and complex direct modulation with coherent detection. More than 30 years since the birth, DM and DD still hold indispensable roles in modern optical communications.

How to achieve synergy between volume replacement and filling products for global facial rejuvenation.

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Raspaldo, Hervé; Aziza, Richard; Belhaouari, Lakhdar; Berros, Philippe; Body, Sylvie; Galatoire, Olivier; Le Louarn, Claude; Michaud, Thierry; Niforos, François; Rousseaux, Isabelle; Runge, Marc; Taieb, Maryna

2011-04-01

The objective of this paper is to provide an expert consensus regarding facial rejuvenation using a combination of volume replacement (Juvéderm(®) VOLUMA(®)), filling products (Juvéderm(®) Ultra product line) and botulinum toxin. The Juvéderm product line exploits innovative 3-D technology, producing a range of cohesive, homogenous gels that produce predictable, long-lasting and natural results. The products are easy to use by practitioners and are well-tolerated by patients, and used in combination can provide additional benefits not achieved with one product alone. An assessment of facial anatomy and consideration of the aging process, as well as available treatment options, are also addressed in determining the best combination of products to use. Outcomes from a questionnaire and workshop sessions focusing on specific aspects of use of the Juvéderm product line and botulinum toxin in daily clinical practice are discussed, and recommendations for product use following debate amongst the experts are provided.

Intense pulsed light for photo-rejuvenation and freckles of middle eastern skin

International Nuclear Information System (INIS)

El Bedewi, A.F.

2003-01-01

Facial ageing is a gradual process which could be due to intrinsic and extrinsic causes and it ultimately results in the appearance of activity induced tissue ptosis, wrinkles, epidermal and dermal artoply, dryness, senile lentigo, flushing, telangiectasia and enlarged pores. Moreover, freckles are frequently seen on the face and other sun exposed areas and it is characterized with incrreased melanin in the epidermis. Intense Pulsed Light (IPL)is the latest technology for selective photo-thermolysis as a non-ablative photo-rejuvenation. Thirty-four patients of age ranging between 35- 70 years with skin type ranging between III-V with or without freckles were treated with 3-5 sessions of IPL. Three weeks intervals were considered between every two succesive session. Irradiation wavelength was controlled using cutoff filters ranging from 535 to 580 nmwith a fluence of 25-35 j/cm-2. Significant improvement was demonstrated after 6 months by computerized image analysis compared with the baseline. IPL was found to be effective and saf treatment for fine wrinkles, facial freckles, telangiectasia, flushing as well as post-inflammatory hyper-pigmentation with a high satisfactory level and a relatively afew adverse effects

Aging, rejuvenation, and memory effects in short-range Ising spin glass: Cu_0.5Co_0.5Cl_2-FeCl3 GBIC

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Suzuki, M.; Suzuki, I. S.

2004-03-01

Cu_0.5Co_0.5Cl_2-FeCl3 GBIC undergoes a spin glass (SG) transition at Tg (= 3.92 ± 0.11 K). The system shows a dynamic behavior that has some similarities and some significant differences compared to a 3D Ising SG.^1 Here we report on non-equilibrium aging dynamics which has been studied using zero-field cooled (ZFC) magnetization and low frequency AC magnetic susceptibility.^2 The time dependence of the relaxation rate S(t) = (1/H)dM_ZFC/dln t for the ZFC magnetization after the ZFC aging protocol, shows a peak at a characteristic time t_cr near a wait time t_w, corresponding to a crossover from quasi equilibrium dynamics to non-equilibrium. The time t_cr strongly depends on t_w, temperature, magnetic field, and the temperature shift. The rejuvenation effect is observed in both i^' and i^'' under the T-shift and H-shift procedures. The memory of the specific spin configurations imprinted during the ZFC aging protocol can be recalled when the system is re-heated at a constant heating rate. The aging, rejuvenation, and memory effects are discussed in terms of the scaling concepts derived from numerical studies on 3D Edwards-Anderson spin glass model. 1. I.S. Suzuki and M. Suzuki, Phys. Rev. B 68, 094424 (2003) 2. M. Suzuki and I.S. Suzuki, cond-mat/0308285

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

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Miki Ando

2015-10-01

Full Text Available The discovery of induced pluripotent stem cells (iPSCs has created promising new avenues for therapies in regenerative medicine. However, the tumorigenic potential of undifferentiated iPSCs is a major safety concern for clinical translation. To address this issue, we demonstrated the efficacy of suicide gene therapy by introducing inducible caspase-9 (iC9 into iPSCs. Activation of iC9 with a specific chemical inducer of dimerization (CID initiates a caspase cascade that eliminates iPSCs and tumors originated from iPSCs. We introduced this iC9/CID safeguard system into a previously reported iPSC-derived, rejuvenated cytotoxic T lymphocyte (rejCTL therapy model and confirmed that we can generate rejCTLs from iPSCs expressing high levels of iC9 without disturbing antigen-specific killing activity. iC9-expressing rejCTLs exert antitumor effects in vivo. The system efficiently and safely induces apoptosis in these rejCTLs. These results unite to suggest that the iC9/CID safeguard system is a promising tool for future iPSC-mediated approaches to clinical therapy.

Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation

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Zhi-Jie Liang

2018-05-01

Full Text Available Background/Aims: The rejuvenation properties of nanofat grafting have been described in recent years. However, it is not clear whether the clinical efficacy of the procedure is attributable to stem cells or linked to other components of adipose tissue. In this study we isolated nanofat-derived stem cells (NFSCs to observe their biological characteristics and evaluate the efficacy of precise intradermal injection of nanofat combined with platelet-rich fibrin (PRF in patients undergoing facial rejuvenation treatment. Methods: Third-passage NFSCs were isolated and cultured using a mechanical emulsification method and their surface CD markers were analyzed by flow cytometry. The adipogenic and osteogenic nature and chondrogenic differentiation capacity of NFSCs were determined using Oil Red O staining, alizarin red staining, and Alcian blue staining, respectively. Paracrine function of NFSCs was evaluated by enzyme-linked immunosorbent assay (ELISA at 1, 3, 7, 14, and 28 days after establishing the culture. Then, the effects of PRF on NFSC proliferation were assessed in vitro. Finally, we compared the outcome in 103 patients with facial skin aging who underwent both nanofat and intradermal PRF injection (treatment group and 128 patients who underwent hyaluronic acid (HA injection treatment (control group. Outcomes in the two groups were compared by assessing pictures taken at the same angle before and after treatment, postoperative recovery, incidence of local absorption and cysts, and skin quality before treatment, and at 1, 12, 24 months after treatment using the VISIA Skin Image Analyzer and a SOFT5.5 skin test instrument. Results: NFSCs expressed CD29, CD44, CD49d, CD73, CD90, and CD105, but did not express CD34, CD45, and CD106. NFSCs also differentiated into adipocytes, osteoblasts, and chondrocytes under appropriate induction conditions. NFSCs released large amounts of growth factors such as VEGF, bFGF, EGF, and others, and growth factor

Sleep, Stress & Relaxation: Rejuvenate Body & Mind

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Finesse in forehead and brow rejuvenation: modern concepts, including endoscopic methods.

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Drolet, Brian C; Phillips, Benjamin Z; Hoy, Erik A; Chang, Johnny; Sullivan, Patrick K

2014-12-01

The brow and forehead are essential elements of the facial aesthetic architecture. Although frequently overlooked in youth, signs of facial aging are often most noticeable in the upper third of the face. Ptosis and loss of contour in the brows, along with temporal volume loss, sagging of periorbital tissue, and rhytides in the forehead, are common presenting complaints for aesthetic surgery. Although use of nonsurgical procedures (e.g., neuromodulators) has become very common practice, knowledge of surgical anatomy and interventions for brow and forehead rejuvenation are critical for a plastic surgeon. The earliest descriptions of brow-lift procedures are nearly a century old. Techniques have evolved significantly, to the point that patients may now return to work within 1 week of surgery, with minimal or no stigmata from an operation. The literature and a series of cases from the senior surgeon (P.K.S.) were reviewed. A minimally invasive approach with an endoscope for dissection and repositioning of the brow was used in all patients. The authors have found that permanent suture fixation with cortical tunnels can produce an excellent, long-lasting aesthetic result for not only the forehead and brow but also the lateral periorbital and temporal regions. Although each operation is tailored to the patient's individual anatomy, the authors' approach to the endoscopic procedure is described in this article, along with a review of anatomical and surgical considerations. Finally, several patients provide demonstrative results from the senior surgeon's series of 546 patients.

Rejuvenation of residual oil hydrotreating catalysts by leaching of foulant metals. Modelling of the metal leaching process

Energy Technology Data Exchange (ETDEWEB)

Marafi, M.; Kam, E.K.T.; Stanislaus, A.; Absi-Halabi, M. [Petroleum Technology Department, Petroleum, Petrochemicals and Materials Division, Kuwait Institute for Scientific Research, Safat (Kuwait)

1996-11-19

Increasing emphasis has been paid in recent years on the development of processes for the rejuvenation of spent residual oil hydroprocessing catalysts, which are deactivated by deposition of metals (e.g. vanadium) and coke. As part of a research program on this subject, we have investigated selective removal of the major metal foulant from the spent catalyst by chemical leaching. In the present paper, we report the development of a model for foulant metals leaching from the spent catalyst. The leaching process is considered to involve two consecutive operations: (1) removal of metal foulants along the main mass transfer channels connected to the narrow pores until the pore structure begins to develop and (2) removal of metal foulants from the pore structure. Both kinetic and mass transfer aspects were considered in the model development, and a good agreement was noticed between experimental and simulated results

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

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Safdar, Adeel; Bourgeois, Jacqueline M.; Ogborn, Daniel I.; Little, Jonathan P.; Hettinga, Bart P.; Akhtar, Mahmood; Thompson, James E.; Melov, Simon; Mocellin, Nicholas J.; Kujoth, Gregory C.; Prolla, Tomas A.; Tarnopolsky, Mark A.

2011-01-01

A causal role for mitochondrial DNA (mtDNA) mutagenesis in mammalian aging is supported by recent studies demonstrating that the mtDNA mutator mouse, harboring a defect in the proofreading-exonuclease activity of mitochondrial polymerase gamma, exhibits accelerated aging phenotypes characteristic of human aging, systemic mitochondrial dysfunction, multisystem pathology, and reduced lifespan. Epidemiologic studies in humans have demonstrated that endurance training reduces the risk of chronic diseases and extends life expectancy. Whether endurance exercise can attenuate the cumulative systemic decline observed in aging remains elusive. Here we show that 5 mo of endurance exercise induced systemic mitochondrial biogenesis, prevented mtDNA depletion and mutations, increased mitochondrial oxidative capacity and respiratory chain assembly, restored mitochondrial morphology, and blunted pathological levels of apoptosis in multiple tissues of mtDNA mutator mice. These adaptations conferred complete phenotypic protection, reduced multisystem pathology, and prevented premature mortality in these mice. The systemic mitochondrial rejuvenation through endurance exercise promises to be an effective therapeutic approach to mitigating mitochondrial dysfunction in aging and related comorbidities. PMID:21368114

NESTED SHELLS REVEAL THE REJUVENATION OF THE ORION–ERIDANUS SUPERBUBBLE

International Nuclear Information System (INIS)

Ochsendorf, Bram B.; Brown, Anthony G. A.; Tielens, Alexander G. G. M.; Bally, John

2015-01-01

The Orion–Eridanus superbubble is the prototypical superbubble owing to its proximity and evolutionary state. Here we provide a synthesis of recent observational data from WISE and Planck with archival data, allowing us to draw a new and more complete picture on the history and evolution of the Orion–Eridanus region. We discuss the general morphological structures and observational characteristics of the superbubble and derive quantitative properties of the gas and dust inside Barnard’s Loop. We reveal that Barnard’s Loop is a complete bubble structure that, together with the λ Ori region and other smaller-scale bubbles, expands within the Orion–Eridanus superbubble. We argue that the Orion–Eridanus superbubble is larger and more complex than previously thought, and that it can be viewed as a series of nested shells, superimposed along the line of sight. During the lifetime of the superbubble, Hii region champagne flows and thermal evaporation of embedded clouds continuously mass-load the superbubble interior, while winds or supernovae from the Orion OB association rejuvenate the superbubble by sweeping up the material from the interior cavities in an episodic fashion, possibly triggering the formation of new stars that form shells of their own. The steady supply of material into the superbubble cavity implies that dust processing from interior supernova remnants is more efficient than previously thought. The cycle of mass loading, interior cleansing, and star formation repeats until the molecular reservoir is depleted or the clouds have been disrupted. While the nested shells come and go, the superbubble remains for tens of millions of years

NESTED SHELLS REVEAL THE REJUVENATION OF THE ORION–ERIDANUS SUPERBUBBLE

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Ochsendorf, Bram B.; Brown, Anthony G. A.; Tielens, Alexander G. G. M. [Leiden Observatory, Leiden University, P.O. Box 9513, NL-2300 RA (Netherlands); Bally, John, E-mail: ochsendorf@strw.leidenuniv.nl [CASA, APS, UCB389, University of Colorado, Boulder, CO 80389 (United States)

2015-08-01

The Orion–Eridanus superbubble is the prototypical superbubble owing to its proximity and evolutionary state. Here we provide a synthesis of recent observational data from WISE and Planck with archival data, allowing us to draw a new and more complete picture on the history and evolution of the Orion–Eridanus region. We discuss the general morphological structures and observational characteristics of the superbubble and derive quantitative properties of the gas and dust inside Barnard’s Loop. We reveal that Barnard’s Loop is a complete bubble structure that, together with the λ Ori region and other smaller-scale bubbles, expands within the Orion–Eridanus superbubble. We argue that the Orion–Eridanus superbubble is larger and more complex than previously thought, and that it can be viewed as a series of nested shells, superimposed along the line of sight. During the lifetime of the superbubble, Hii region champagne flows and thermal evaporation of embedded clouds continuously mass-load the superbubble interior, while winds or supernovae from the Orion OB association rejuvenate the superbubble by sweeping up the material from the interior cavities in an episodic fashion, possibly triggering the formation of new stars that form shells of their own. The steady supply of material into the superbubble cavity implies that dust processing from interior supernova remnants is more efficient than previously thought. The cycle of mass loading, interior cleansing, and star formation repeats until the molecular reservoir is depleted or the clouds have been disrupted. While the nested shells come and go, the superbubble remains for tens of millions of years.

Stem cells rejuvenate radiation-impaired vasculogenesis in murine distraction osteogenesis.

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Deshpande, Sagar S; Gallagher, Kathleen K; Donneys, Alexis; Nelson, Noah S; Guys, Nicholas P; Felice, Peter A; Page, Erin E; Sun, Hongli; Krebsbach, Paul H; Buchman, Steven R

2015-03-01

Radiotherapy is known to be detrimental to bone and soft-tissue repair. Bone marrow stromal cells have been shown to enhance bone regeneration during distraction osteogenesis following radiation therapy. The authors posit that transplanted bone marrow stromal cells will significantly augment the mandibular vascularity devastated by radiation therapy. Nineteen male Lewis rats were split randomly into three groups: distraction osteogenesis only (n = 5), radiation therapy plus distraction osteogenesis (n = 7), and radiation therapy plus distraction osteogenesis with intraoperative placement of 2 million bone marrow stromal cells (n = 7). A mandibular osteotomy was performed, and an external fixator device was installed. From postoperative days 4 through 12, rats underwent a gradual 5.1-mm distraction followed by a 28-day consolidation period. On postoperative day 40, Microfil was perfused into the vasculature and imaging commenced. Vascular radiomorphometric values were calculated for regions of interest. An analysis of variance with post hoc Tukey or Games-Howell tests was used, dependent on data homogeneity. Stereologic analysis indicated significant remediation in vasculature in the bone marrow stromal cell group compared with the radiation therapy/distraction osteogenesis group. Each of five metrics idicated significant improvements from radiation therapy/distraction osteogenesis to the bone marrow stromal cell group, with no difference between the bone marrow stromal cell group and the distraction osteogenesis group. Bone marrow stromal cells used together with distraction osteogenesis can rejuvenate radiation-impaired vasculogenesis in the mandible, reversing radiation therapy-induced isotropy and creating a robust vascular network. Bone marrow stromal cells may offer clinicians an alternative reconstructive modality that could improve the lifestyle of patients with hypovascular bone.

Rejuvenation Using Platelet-rich Plasma and Lipofilling for Vaginal Atrophy and Lichen Sclerosus

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Kim, Seok Hwan; Kim, Tae Hee

2017-01-01

Vaginal atrophy is a common condition among peri- and post-menopausal women. Symptoms of vaginal dryness, pruritus, irritation, loss of subcutaneous fat, sparse pubic hair and dyspareunia occur due to decreased estrogen level. Estrogen-based treatments are effective. But many patients are reluctant to be treated due to health concerns. As alternatives, we explored the efficacy of platelet-rich plasma (PRP) and lipofilling. A 67-year-old female patient with vaginal atrophy was referred to our department. Treatment using estrogen cream had failed to improve patient's symptoms. Diminished volume and aged look of genitalia were also major concerns. We treated her using lipofilling mixed with PRP. A total of 40 cc of autologous fat mixed with PRP was transferred to labia majora. Lipofilling with PRP relieved the clinical symptoms. Missing fullness and tone was corrected and the augmented volume was well maintained. White patchy lesions of lichen sclerosus on labia minora also improved. Lipofilling with PRP relieved symptoms, restored contour of the labia majora and achieved remission of lichen sclerosus on labia minora. As vulvar lesions were repaired and the aged appearance of genitalia was rejuvenated, both functional and cosmetic outcomes were satisfactory. Lipofilling with PRP can be effective for vaginal atrophy and lichen sclerosus. PMID:28523261

Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation

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Korkina, Liudmila G.; Mayer, Wolfgang; de Luca, Chiara

2017-01-01

Recently, aggressive advertisement claimed a “magic role” for plant stem cells in human skin rejuvenation. This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics. When meristem cell cultures obtained from medicinal plants are exposed to appropriate elicitors/stressors (ultraviolet, ultrasound ultraviolet (UV), ultrasonic waves, microbial/insect metabolites, heavy metals, organic toxins, nutrient deprivation, etc.), a protective/adaptive response initiates the biosynthesis of secondary metabolites. Highly bioavailable and biocompatible to human cells, low-molecular weight plant secondary metabolites share structural/functional similarities with human non-protein regulatory hormones, neurotransmitters, pigments, polyamines, amino-/fatty acids. Their redox-regulated biosynthesis triggers in turn plant cell antioxidant and detoxification molecular mechanisms resembling human cell pathways. Easily isolated in relatively large quantities from contaminant-free cell cultures, plant metabolites target skin ageing mechanisms, above all redox imbalance. Perfect modulators of cutaneous oxidative state via direct/indirect antioxidant action, free radical scavenging, UV protection, and transition-metal chelation, they are ideal candidates to restore photochemical/redox/immune/metabolic barriers, gradually deteriorating in the ageing skin. The industrial production of plant meristem cell metabolites is toxicologically and ecologically sustainable for fully “biological” anti-age cosmetics. PMID:28498360

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Science.gov (United States)

Gupta, Divya; Singh, Ajeet; Khan, Asad U.

2017-07-01

The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of antibiotics, like drug amelioration, target modification, membrane permeability reduction, and drug extrusion through efflux pumps. Efflux pumps acquire a wide range of substrate specificity and also the tremendous efficacy for drug molecule extrusion outside bacterial cells. Hindrance in the functioning of efflux pumps may rejuvenate the bactericidal effect of conventional antibiotics. Efflux pumps also play an important role in the exclusion or inclusion of quorum-sensing biomolecules responsible for biofilm formation in bacterial cells. This transit movement of quorum-sensing biomolecules inside or outside the bacterial cells may get interrupted by impeding the functioning of efflux pumps. Metallic nanoparticles represent a potential candidate to block efflux pumps of bacterial cells. The application of nanoparticles as efflux pump inhibitors will not only help to revive the bactericidal effect of conventional antibiotics but will also assist to reduce biofilm-forming capacity of microbes. This review focuses on a novel and fascinating application of metallic nanoparticles in synergy with conventional antibiotics for efflux pump inhibition.

Photobiomodulation of distinct lineages of human dermal fibroblasts: a rational approach towards the selection of effective light parameters for skin rejuvenation and wound healing

Science.gov (United States)

Mignon, Charles; Uzunbajakava, Natallia E.; Raafs, Bianca; Moolenaar, Mitchel; Botchkareva, Natalia V.; Tobin, Desmond J.

2016-03-01

Distinct lineages of human dermal fibroblasts play complementary roles in skin rejuvenation and wound healing, which makes them a target of phototherapy. However, knowledge about differential responses of specific cell lineages to different light parameters and moreover the actual molecular targets remain to be unravelled. The goal of this study was to investigate the impact of a range of parameters of light on the metabolic activity, collagen production, and cell migration of distinct lineages of human dermal fibroblasts. A rational approach was used to identify parameters with high therapeutic potential. Fibroblasts exhibited both inhibitory and cytotoxic change when exposed to a high dose of blue and cyan light in tissue culture medium containing photo-reactive species, but were stimulated by high dose red and near infrared light. Cytotoxic effects were eliminated by refreshing the medium after light exposure by removing potential ROS formed by extracellular photo-reactive species. Importantly, distinct lineages of fibroblasts demonstrated opposite responses to low dose blue light treatment when refreshing the medium after exposure. Low dose blue light treatment also significantly increased collagen production by papillary fibroblasts; high dose significantly retarded closure of the scratch wound without signs of cytotoxicity, and this is likely to have involved effects on both cell migration and proliferation. We recommend careful selection of fibroblast subpopulations and their culture conditions, a systematic approach in choosing and translating treatment parameters, and pursuit of fundamental research on identification of photoreceptors and triggered molecular pathways, while seeking effective parameters to address different stages of skin rejuvenation and wound healing.

Expanded Stem Cells, Stromal-Vascular Fraction, and Platelet-Rich Plasma Enriched Fat: Comparing Results of Different Facial Rejuvenation Approaches in a Clinical Trial.

Science.gov (United States)

Rigotti, Gino; Charles-de-Sá, Luiz; Gontijo-de-Amorim, Natale Ferreira; Takiya, Christina Maeda; Amable, Paola Romina; Borojevic, Radovan; Benati, Donatella; Bernardi, Paolo; Sbarbati, Andrea

2016-03-01

In a previous study, the authors demonstrated that treatment with expanded adipose-derived stem cells or stromal vascular fraction (SVF)-enriched fat modify the pattern of the dermis in human beings, representing a skin rejuvenation effect. Considering that expanded stem cells require a cell factor, the authors wanted to assess similar results by replacing them with platelet-rich plasma (PRP), which is easier to obtain and for which an empirical regenerative effect has been already described. To determine if PRP injection could replace the cutaneous regenerative effect of adipose-derived stem cells. This study was performed in 13 patients who were candidates for facelift. The patients underwent sampling of fat by liposuction from the abdomen and submitted to one of three protocols: injection of SVF-enriched fat or expanded adipose-derived stem cells or fat plus PRP in the preauricular areas. Fragments of skin were removed before and 3 months after treatment and analyzed by optical and electron microscopy. The use of fat plus PRP led to the presence of more pronounced inflammatory infiltrates and a greater vascular reactivity, increasing in vascular permeability and a certain reactivity of the nervous component. The addition of PRP did not improve the regenerative effect. The use of PRP did not have significant advantages in skin rejuvenation over the use of expanded adipose-derived stem cells or SVF-enriched fat. The effect of increased vascular reactivity may be useful in pathological situations in which an intense angiogenesis is desirable, such as tissular ischemia. © 2016 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com.

Using amphiphilic nanostructures to enable long-range ensemble coalescence and surface rejuvenation in dropwise condensation.

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Anderson, David M; Gupta, Maneesh K; Voevodin, Andrey A; Hunter, Chad N; Putnam, Shawn A; Tsukruk, Vladimir V; Fedorov, Andrei G

2012-04-24

Controlling coalescence events in a heterogeneous ensemble of condensing droplets on a surface is an outstanding fundamental challenge in surface and interfacial sciences, with a broad practical importance in applications ranging from thermal management of high-performance electronic devices to moisture management in high-humidity environments. Nature-inspired superhydrophobic surfaces have been actively explored to enhance heat and mass transfer rates by achieving favorable dynamics during dropwise condensation; however, the effectiveness of such chemically homogeneous surfaces has been limited because condensing droplets tend to form as pinned Wenzel drops rather than mobile Cassie ones. Here, we introduce an amphiphilic nanostructured surface, consisting of a hydrophilic base with hydrophobic tips, which promotes the periodic regeneration of nucleation sites for small droplets, thus rendering the surface self-rejuvenating. This unique amphiphilic nanointerface generates an arrangement of condensed Wenzel droplets that are fluidically linked by a wetted sublayer, promoting previously unobserved coalescence events where numerous droplets simultaneously merge, without direct contact. Such ensemble coalescences rapidly create fresh nucleation sites, thereby shifting the overall population toward smaller droplets and enhancing the rates of mass and heat transfer during condensation.

Model of slums rejuvenation in Telaga Tujuh village: the case of Langsa city, Aceh, Indonesia

Science.gov (United States)

Irwansyah, Mirza; Caisarina, Irin; Solehati, Dini

2018-05-01

Telaga Tujuh village is the only island inhabited compared to other islands in Langsa City, Aceh. Most of the houses are on stilts with very limited infrastructure such as lack of road facilities, local drainage, drinking water, wastewater, and garbage disposals. In determining the model of the slum settlements arrangement of Telaga Tujuh Village, there are some things to know that the characteristics of slums themselves and the causes of slum settlement. The aim of this study is to determine model of slum settlement arrangement that is suitable to be applied in the location. The method used is qualitative with sampling technique and qualitative analysis. To obtain the primary data used observation method, questionnaires, and interview. Secondary data obtained from agencies related to slum settlement arrangement. Based on characteristic analysis found that 365 residential buildings are irregular with the percentage of 100%, 365 residential buildings do not have safe drinking water supply, 365 residential buildings do not have waste water management. From the analysis shows that the appropriate model to be applied to Telaga Tujuh village is the rejuvenation model with the land consolidation system through the re-arrangement divided by two, 60% for the existing residential development and 40% for commercial development.

Particle rejuvenation of Rao-Blackwellized sequential Monte Carlo smoothers for conditionally linear and Gaussian models

Science.gov (United States)

Nguyen, Ngoc Minh; Corff, Sylvain Le; Moulines, Éric

2017-12-01

This paper focuses on sequential Monte Carlo approximations of smoothing distributions in conditionally linear and Gaussian state spaces. To reduce Monte Carlo variance of smoothers, it is typical in these models to use Rao-Blackwellization: particle approximation is used to sample sequences of hidden regimes while the Gaussian states are explicitly integrated conditional on the sequence of regimes and observations, using variants of the Kalman filter/smoother. The first successful attempt to use Rao-Blackwellization for smoothing extends the Bryson-Frazier smoother for Gaussian linear state space models using the generalized two-filter formula together with Kalman filters/smoothers. More recently, a forward-backward decomposition of smoothing distributions mimicking the Rauch-Tung-Striebel smoother for the regimes combined with backward Kalman updates has been introduced. This paper investigates the benefit of introducing additional rejuvenation steps in all these algorithms to sample at each time instant new regimes conditional on the forward and backward particles. This defines particle-based approximations of the smoothing distributions whose support is not restricted to the set of particles sampled in the forward or backward filter. These procedures are applied to commodity markets which are described using a two-factor model based on the spot price and a convenience yield for crude oil data.

The safety and efficacy of a combined diode laser and bipolar radiofrequency compared with combined infrared light and bipolar radiofrequency for skin rejuvenation

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Yeon Jin Choi

2012-01-01

Full Text Available Background: As the demand for noninvasive procedures for skin rejuvenation is increasing, combined diode laser and radiofrequency and combined infrared and radiofrequency devices have recently emerged. Aim: To compare Polaris WRA TM , a combination device of diode light and RF, and ReFirme ST TM , a combination device of infrared and bipolar RF, in terms of safety and efficacy on skin rejuvenation. Methods: Fourteen Korean volunteers of skin type II-IV, with facial laxity and periorbital rhytids, received three treatments at 3-week intervals with combined diode laser and bipolar radiofrequency (laser fluence 30 J/cm 2 , RF fluence 90 J/cm 3 on the right half of their faces and combined infrared light and bipolar radiofrequency (RF fluence 120 J/cm 3 on the left half of their faces. Clinical photos of front and bilateral sides of the subjects′ faces were taken at baseline and at 6, 9, 12 weeks after the treatment initiation. The investigators′ and the subjects′ global assessments were performed. Results: There is no statistically significant difference in the overall outcome between Polaris WRA TM and Refirme ST TM based on pre- and post-treatment objective measurements. Polaris WRA TM was more effective than Refirme ST TM at reducing wrinkles when therapeutic results of the two appliances were compared based on the patient satisfaction measurements. After the treatment with both instruments, histological increase in the production and rearrangement of collagen fibers at the dermal layer was observed. The density of the collagen fibers was more increased with the Polaris WRA TM -treated facial area than that of Refirme ST TM . Treatment was generally well tolerated, and there was no serious complication. Conclusion: In this study, both the lasers appeared to be safe, and effective methods for treating skin laxity and facial wrinkles. Combined diode laser and radiofrequency was more effective than combined infrared and radiofrequency at

The safety and efficacy of a combined diode laser and bipolar radiofrequency compared with combined infrared light and bipolar radiofrequency for skin rejuvenation.

Science.gov (United States)

Choi, Yeon Jin; Lee, Jung Yeon; Ahn, Ji Young; Kim, Myeung Nam; Park, Mi Youn

2012-01-01

As the demand for noninvasive procedures for skin rejuvenation is increasing, combined diode laser and radiofrequency and combined infrared and radiofrequency devices have recently emerged. To compare Polaris WRA(TM), a combination device of diode light and RF, and ReFirme ST(TM), a combination device of infrared and bipolar RF, in terms of safety and efficacy on skin rejuvenation. Fourteen Korean volunteers of skin type II-IV, with facial laxity and periorbital rhytids, received three treatments at 3-week intervals with combined diode laser and bipolar radiofrequency (laser fluence 30 J/cm2, RF fluence 90 J/cm3) on the right half of their faces and combined infrared light and bipolar radiofrequency (RF fluence 120 J/cm3) on the left half of their faces. Clinical photos of front and bilateral sides of the subjects' faces were taken at baseline and at 6, 9, 12 weeks after the treatment initiation. The investigators' and the subjects' global assessments were performed. There is no statistically significant difference in the overall outcome between Polaris WRA(TM) and Refirme ST(TM) based on pre- and post-treatment objective measurements. Polaris WRA(TM) was more effective than Refirme ST(TM) at reducing wrinkles when therapeutic results of the two appliances were compared based on the patient satisfaction measurements. After the treatment with both instruments, histological increase in the production and rearrangement of collagen fibers at the dermal layer was observed. The density of the collagen fibers was more increased with the Polaris WRA(TM)-treated facial area than that of Refirme ST(TM). Treatment was generally well tolerated, and there was no serious complication. In this study, both the lasers appeared to be safe, and effective methods for treating skin laxity and facial wrinkles. Combined diode laser and radiofrequency was more effective than combined infrared and radiofrequency at reducing wrinkles and pores when the therapeutic results of both the

Face and labial rejuvenation with the new Nd-Yag 1064 picoseconds laser

Science.gov (United States)

Teixeira, Heitor; Teixeira, Carolina

2018-04-01

Lips are the component of the oral cavity which synthesizes more functions and emotions. The nonverbal communication is established by the body, every movement gesture, posture and facial expression which shows a willingness to communicate directly or subtly, consciously or unconsciously. The smile is one of the expressions that attract us the most, for its simplicity and mainly for its puzzle. In Lips aging implies a loss of mucous membranes' density; lips' dehydrate and resect themselves, reducing its' thickness which causes an appearance of aging of the all face. The demands of public opinion of being young and stay young are becoming more and more pressing, therefore it is necessary to meet this demand. The responsibility of achieving this task is up to the doctor, the anti-aging medicine and the actual existing physical means, which are available to correct and prevent this disease. Having the possibility of using the new picoseconds Nd-Yag Laser in Lips' rejuvenation we must use them together and in accordance between them and the guideline we presented what we believe to be the guideline which allows us to obtain good results in a new and simple effective treatment that can be proved by the major aspect of the lip and by evidence and monitoring that we went through for about ten month. Obtained results of labial cracks' disappearance inside of the red mucosa increase in lips' volume and contour and disappearance of oral wrinkles creates an aesthetic appearance witch is remarkable. This is a non invasive method with minimal complications with low morbidity and in our opinion superior results when compared to other traditional methods considered soft tissue augmentation including peelings, botox injections, injectable fillers such as hyaluronic acid injections temporary and permanent injectable bio-implants, bio- catalysts and even surgery of the upper lip.

Sustainable and long-time 'rejuvenation' of biomimetic water-repellent silica coating on polyester fabrics induced by rough mechanical abrasion.

Science.gov (United States)

Rosu, Cornelia; Lin, Haisheng; Jiang, Lu; Breedveld, Victor; Hess, Dennis W

2018-04-15

The economical use of water-repellent coatings on polymeric materials in commercial and industrial applications is limited by their mechanical wear robustness and long-term durability. In this study, we demonstrate that polyethylene terephthalate (PET) fabric modified with inorganic, methyltrimethoxysilane (MTMS)-based coatings shows excellent resistance against various types of wear damage, thereby mimicking superhydrophobic biological materials. These features were facilitated by the rational design of coating processing that also enabled tunable hierarchical surface structure. A series of custom and standard testing protocols revealed that coating-to-substrate adhesion was remarkably high, as was the resistance to various mechanical abradents. The most intriguing characteristic observed during aging and abrasion cycles was the enhancement in non-wettability or 'rejuvenation' reflected by water droplet roll-off behavior, a characteristic of self-cleaning materials. Water-repellent properties of coated polyester were also enhanced by prolonged thermal annealing and were maintained after custom laundry. The developed technology offers opportunities to design low cost, durable and functional textiles for both indoor and outdoor applications. Copyright © 2018 Elsevier Inc. All rights reserved.

Isotopic signature of Pan-African rejuvenation in the Kerala Khondalite belt, southern India: implications for east Gondwana reassembly

International Nuclear Information System (INIS)

Unnikrishnan Warrier, C.

1997-01-01

Sm-Nd isotope systematics on mineral separates from sillimanite-and cordierite-bearing metapelite (khondalite), and garnet-and biotite-bearing gneiss (leptynite) from the Kerala Khondalite Belt (KKB), southern India, yielded mineral isochron ages (wr-feld-bio-gar) of 537±27 Ma (MSWD=0.9) and 534±26 Ma (MSWD=1.23) respectively. Rb-Sr systematics in the same samples gave wr-feld-bio mineral isochron ages of 437±9 Ma (MSWD=0.67) and 467±9 Ma (MSWD=0.76). These results provide the first mineral isochron ages for the regional metasedimentaries in the KKB. The ε (Nd T) values at 550 Ma for khondalite and leptynite are -22.7 and -21.8 respectively. These results demonstrate a complete rejuvenation of the crust during Pan-African times. Coeval alkaline plutons emplaced along fault-lineaments in this area suggest an extensional tectonic regime. Geochronologic correlations with the Lutzow-Holm bay complexes in east Antarctica, and the highland and southwestern complex of Sri Lanka show that a similar Pan-African tectono-thermal event manifested in all the east Gondwana crustal fragments. (author)

Natural Substances for Prevention of Skin Photoaging: Screening Systems in the Development of Sunscreen and Rejuvenation Cosmetics

Science.gov (United States)

Kostyuk, Vladimir; Potapovich, Alla; Albuhaydar, Ahmed R.; Mayer, Wolfgang; De Luca, Chiara

2018-01-01

Abstract Solar broadband UV irradiation is commonly regarded as a major causative reason for cutaneous photoaging. The pro-aging molecular pathways and cellular targets affected by UVA+UVB light in human skin have been extensively investigated. Notwithstanding growing knowledge in mechanisms of photoaging, research and development of clinically efficient, nontoxic, and sustainable topical preparations providing full physical, chemical, and biological photoprotection still remain a great challenge for pharmaceutical and cosmetic industries. In this study, we are proposing a panel of the in vitro methods for preselection of natural photoprotective substances with high photostability and low phototoxicity able of absorbing a broadband UVA+UVB irradiation (physical sunscreen), reducing UV-related overproduction of free radicals and loss of endogenous antioxidants (chemical protection), and attenuating UV-induced cytotoxicity and immune and metabolic responses (biological protection) in primary human epidermal keratinocytes and immortalized human keratinocyte cultures. Our data showed that secondary metabolites biosynthesized in plant cells in response to UV irradiation, such as phenylpropanoids and their glycosylated metabolites, aglycons and glycosylated flavonoids, and leontopodic acids, hold the best promise for complete natural topical prevention of photoaging and rejuvenation of photoaged skin. Meristem plant cell cultures elicited by solar simulating UV could be the most environmentally sustainable biotechnological source of polyphenols with combined photoprotective and antiaging properties. PMID:28661208

Natural Substances for Prevention of Skin Photoaging: Screening Systems in the Development of Sunscreen and Rejuvenation Cosmetics.

Science.gov (United States)

Kostyuk, Vladimir; Potapovich, Alla; Albuhaydar, Ahmed R; Mayer, Wolfgang; De Luca, Chiara; Korkina, Liudmila

2018-04-01

Solar broadband UV irradiation is commonly regarded as a major causative reason for cutaneous photoaging. The pro-aging molecular pathways and cellular targets affected by UVA+UVB light in human skin have been extensively investigated. Notwithstanding growing knowledge in mechanisms of photoaging, research and development of clinically efficient, nontoxic, and sustainable topical preparations providing full physical, chemical, and biological photoprotection still remain a great challenge for pharmaceutical and cosmetic industries. In this study, we are proposing a panel of the in vitro methods for preselection of natural photoprotective substances with high photostability and low phototoxicity able of absorbing a broadband UVA+UVB irradiation (physical sunscreen), reducing UV-related overproduction of free radicals and loss of endogenous antioxidants (chemical protection), and attenuating UV-induced cytotoxicity and immune and metabolic responses (biological protection) in primary human epidermal keratinocytes and immortalized human keratinocyte cultures. Our data showed that secondary metabolites biosynthesized in plant cells in response to UV irradiation, such as phenylpropanoids and their glycosylated metabolites, aglycons and glycosylated flavonoids, and leontopodic acids, hold the best promise for complete natural topical prevention of photoaging and rejuvenation of photoaged skin. Meristem plant cell cultures elicited by solar simulating UV could be the most environmentally sustainable biotechnological source of polyphenols with combined photoprotective and antiaging properties.

Cybernetic principles of aging and rejuvenation: the buffering- challenging strategy for life extension.

Science.gov (United States)

Heylighen, Francis

2014-01-01

Aging is analyzed as the spontaneous loss of adaptivity and increase in fragility that characterizes dynamic systems. Cybernetics defines the general regulatory mechanisms that a system can use to prevent or repair the damage produced by disturbances. According to the law of requisite variety, disturbances can be held in check by maximizing buffering capacity, range of compensatory actions, and knowledge about which action to apply to which disturbance. This suggests a general strategy for rejuvenating the organism by increasing its capabilities of adaptation. Buffering can be optimized by providing sufficient rest together with plenty of nutrients: amino acids, antioxidants, methyl donors, vitamins, minerals, etc. Knowledge and the range of action can be extended by subjecting the organism to an as large as possible variety of challenges. These challenges are ideally brief so as not to deplete resources and produce irreversible damage. However, they should be sufficiently intense and unpredictable to induce an overshoot in the mobilization of resources for damage repair, and to stimulate the organism to build stronger capabilities for tackling future challenges. This allows them to override the trade-offs and limitations that evolution has built into the organism's repair processes in order to conserve potentially scarce resources. Such acute, "hormetic" stressors strengthen the organism in part via the "order from noise" mechanism that destroys dysfunctional structures by subjecting them to strong, random variations. They include heat and cold, physical exertion, exposure, stretching, vibration, fasting, food toxins, micro-organisms, environmental enrichment and psychological challenges. The proposed buffering-challenging strategy may be able to extend life indefinitely, by forcing a periodic rebuilding and extension of capabilities, while using the Internet as an endless source of new knowledge about how to deal with disturbances.

Intracratonic asthenosphere upwelling and lithosphere rejuvenation beneath the Hoggar swell (Algeria): Evidence from HIMU metasomatised lherzolite mantle xenoliths

Science.gov (United States)

Beccaluva, L.; Azzouni-Sekkal, A.; Benhallou, A.; Bianchini, G.; Ellam, R. M.; Marzola, M.; Siena, F.; Stuart, F. M.

2007-08-01

The mantle xenoliths included in Quaternary alkaline volcanics from the Manzaz-district (Central Hoggar) are proto-granular, anhydrous spinel lherzolites. Major and trace element analyses on bulk rocks and constituent mineral phases show that the primary compositions are widely overprinted by metasomatic processes. Trace element modelling of the metasomatised clinopyroxenes allows the inference that the metasomatic agents that enriched the lithospheric mantle were highly alkaline carbonate-rich melts such as nephelinites/melilitites (or as extreme silico-carbonatites). These metasomatic agents were characterized by a clear HIMU Sr-Nd-Pb isotopic signature, whereas there is no evidence of EM1 components recorded by the Hoggar Oligocene tholeiitic basalts. This can be interpreted as being due to replacement of the older cratonic lithospheric mantle, from which tholeiites generated, by asthenospheric upwelling dominated by the presence of an HIMU signature. Accordingly, this rejuvenated lithosphere (accreted asthenosphere without any EM influence), may represent an appropriate mantle section from which deep alkaline basic melts could have been generated and shallower mantle xenoliths sampled, respectively. The available data on lherzolite xenoliths and alkaline lavas (including He isotopes, Ra Pan-African basement. This can be considered a far-field foreland reaction of the Africa-Europe collisional system since the Eocene.

Mesotherapy for skin rejuvenation: assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross-sectional B-mode scanning.

Science.gov (United States)

Lacarrubba, Francesco; Tedeschi, Aurora; Nardone, Beatrice; Micali, Giuseppe

2008-01-01

Skin-targeted ultrasound is a noninvasive technique that has been extensively used to evaluate age-related dermal changes, and the presence of a subepidermal low-echogenic band (SLEB) has been related to chronic UVR exposure in several studies. Since SLEB echogenicity is photoage-related, the aim of this study was to evaluate, through ultrasound imaging, the effects on skin photoaging of mesotherapy, a treatment approach currently used in cosmetic dermatology for skin rejuvenation. Twenty women (mean age: 46.7 range 40-60 years) with physical signs of moderate photoaging on the dorsum of the hands were enrolled and treated with multiple microinjections of hyaluronic acid (HA) salts of biotechnological origin (1.000 Kd) every week for 4 weeks. In all subjects, ultrasound evaluation was performed at each visit and 1 week after the last treatment to evaluate SLEB echogenicity changes during treatment. At the end of study, a statistically significant (p mesotherapy with HA may be an effective treatment for skin photoaging, as confirmed by ultrasound. Follow-up investigations on larger series of patients are necessary to further evaluate the safety, effectiveness, and duration of effect of this possible therapeutic approach to skin photoaging.

Multiple minimally invasive Erbium:YAG laser mini-peels for skin rejuvenation: An objective assessment

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El-Domyati, Moetaz; El-Ammawi, Tarek S.; Medhat, Walid; Moawad, Osama; Mahoney, Mỹ G.; Uitto, Jouni

2012-01-01

Summary Background As the demand for minimally invasive rejuvenation is increasing, micro-peel resurfacing using Erbium:Yttrium Aluminium Garnet (Er:YAG ) laser 2940 nm has been reported for the treatment of photoaged skin without ablation of the epidermis. However, little is known about the efficacy and underlying histologic changes associated with this type of treatment. Aims The purpose of this study is to evaluate the clinical effect and objectively quantify the histological changes in response to multiple sessions of Er:YAG laser 2940 nm mini-peels. Patients and methods Six female volunteers of Fitzpatrick skin type III-IV and Glogau’s class I-III wrinkles were subjected to six microresurfacing peels at 2-week intervals using Er:YAG 2940 nm laser at sub-ablative fluences of 2 - 3 J/cm2 to treat periorbital rhytides. Quantitative evaluation of collagen types I, III and VII, newly synthesized collagen, total elastin and tropoelastin was performed by histochemistry and immunohistochemistry coupled with computerized morphometric analysis at base line, end of treatment, and three months post treatment. Results Compared to the base line, evaluation of volunteers revealed obvious clinical improvement in response to Er:YAG mini-peels. Collagen types I, III, and VII, as well as newly synthesized collagen, together with tropoelastin showed a statistically significant increase in response to treatment, while the mean level of total elastin was significantly decreased in response to treatment. However, this was followed by regression of improvement at 3 months post treatment, but was still better than baseline. Conclusions The present study revealed that multiple Er:YAG mini-peels is a promising treatment option for photoaging as it reverses the signs of photoaged skin with little downtime and side effects. However, to maintain the short term improvement achieved after treatment, continued Er:YAG 2940 nm laser mini-peels is required. PMID:22672276

Fractional versus ablative erbium:yttrium-aluminum-garnet laser resurfacing for facial rejuvenation: an objective evaluation.

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El-Domyati, Moetaz; Abd-El-Raheem, Talal; Abdel-Wahab, Hossam; Medhat, Walid; Hosam, Wael; El-Fakahany, Hasan; Al Anwer, Mustafa

2013-01-01

Laser is one of the main tools for skin resurfacing. Erbium:yttrium-aluminum-garnet (Er:YAG) was the second ablative laser, after carbon dioxide, emitting wavelength of 2940 nm. Fractional laser resurfacing has been developed to overcome the drawbacks of ablative lasers. We aimed to objectively evaluate the histopathological and immunohistochemical effects of Er:YAG 2940-nm laser for facial rejuvenation (multiple sessions of fractional vs single session of ablative Er:YAG laser). Facial resurfacing with single-session ablative Er:YAG laser was performed on 6 volunteers. Another 6 were resurfaced using fractional Er:YAG laser (4 sessions). Histopathological (hematoxylin-eosin, orcein, Masson trichrome, and picrosirius red stains) and immunohistochemical assessment for skin biopsy specimens were done before laser resurfacing and after 1 and 6 months. Histometry for epidermal thickness and quantitative assessment for neocollagen formation; collagen I, III, and VII; elastin; and tropoelastin were done for all skin biopsy specimens. Both lasers resulted in increased epidermal thickness. Dermal collagen showed increased neocollagen formation with increased concentration of collagen types I, III, and VII. Dermal elastic tissue studies revealed decreased elastin whereas tropoelastin concentration increased after laser resurfacing. Neither laser showed significant difference between their effects clinically and on dermal collagen. Changes in epidermal thickness, elastin, and tropoelastin were significantly more marked after ablative laser. The small number of patients is a limitation, yet the results show significant improvement. Multiple sessions of fractional laser have comparable effects to a single session of ablative Er:YAG laser on dermal collagen but ablative laser has more effect on elastic tissue and epidermis. Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

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Iannitti T

2013-09-01

Full Text Available T Iannitti,1,2 V Rottigni,2,3 B Palmieri2,31School of Biomedical Sciences, University of Leeds, Leeds, UK; 2Poliambulatorio del Secondo Parere, Modena, Italy; 3Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, ItalyBackground and aim: The use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil® to manage facial swelling, edema, inflammation, ecchymosis, and hematoma, when applied immediately after a facial rejuvenation procedure.Materials and methods: We applied the plaster to the skin of 20 healthy patients for 12 hours immediately after hyaluronic acid-based procedure performed with the aim of erasing facial wrinkles of perioral and nasolabial folds and improving chin and eye contour. A further 20 patients underwent the same cosmetic procedure, but they were treated with an aescin 10% cream (applied immediately after the procedure, in the evening, and the morning after and served as control group.Results: Betesil® application resulted in a significant improvement in swelling/edema/inflammation score, if compared with aescin 10% cream (P < 0.01. As for facial ecchymosis and hematoma around the needle injection track, only two patients in the active treatment group displayed minimal ecchymosis and hematoma. In the control group, two patients presented minimal ecchymosis and three slight hematoma. However, using the ecchymosis/hematoma score, no significant difference between Betesil® and aescin 10% cream groups was observed. Patients’ satisfaction was significantly higher among subjects receiving Betesil®, if compared to patients receiving aescin 10% cream (P < 0.01.Conclusion: The present study supports the use of Betesil® plaster immediately after facial cosmetic procedures in order

Bioactive reagents used in mesotherapy for skin rejuvenation in vivo induce diverse physiological processes in human skin fibroblasts in vitro- a pilot study.

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Jäger, Claudia; Brenner, Christiane; Habicht, Jüri; Wallich, Reinhard

2012-01-01

The promise of mesotherapy is maintenance and/or recovery of a youthful skin with a firm, bright and moisturized texture. Currently applied medications employ microinjections of hyaluronic acid, vitamins, minerals and amino acids into the superficial layer of the skin. However, the molecular and cellular processes underlying mesotherapy are still elusive. Here we analysed the effect of five distinct medication formulas on pivotal parameters involved in skin ageing, that is collagen expression, cell proliferation and morphological changes using normal human skin fibroblast cultures in vitro. Whereas in the presence of hyaluronic acid, NCTF135(®) and NCTF135HA(®) , cell proliferation was comparable to control cultures; however, with higher expression of collagen type-1, matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1, addition of Soluvit(®) N and Meso-BK led to apoptosis and/or necrosis of human fibroblasts. The data indicate that bioactive reagents currently applied for skin rejuvenation elicit strikingly divergent physiological processes in human skin fibroblast in vitro. © 2011 John Wiley & Sons A/S.

Nanofat-derived stem cells with platelet-rich fibrin improve facial contour remodeling and skin rejuvenation after autologous structural fat transplantation

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Liang, Zhi-Jie; Chen, Hai; Zhu, Mao-Guang; Xu, Fang-Tian; He, Ning; Wei, Xiao-Juan; Li, Hong-Mian

2017-01-01

Traditional autologous fat transplantation is a common surgical procedure for treating facial soft tissue depression and skin aging. However, the transplanted fat is easily absorbed, reducing the long-term efficacy of the procedure. Here, we examined the efficacy of nanofat-assisted autologous fat structural transplantation. Nanofat-derived stem cells (NFSCs) were isolated, mechanically emulsified, cultured, and characterized. Platelet-rich fibrin (PRF) enhanced proliferation and adipogenic differentiation of NFSCs in vitro. We then compared 62 test group patients with soft tissue depression or signs of aging who underwent combined nanofat, PRF, and autologous fat structural transplantation to control patients (77 cases) who underwent traditional autologous fat transplantation. Facial soft tissue depression symptoms and skin texture were improved to a greater extent after nanofat transplants than after traditional transplants, and the nanofat group had an overall satisfaction rate above 90%. These data suggest that NFSCs function similarly to mesenchymal stem cells and share many of the biological characteristics of traditional fat stem cell cultures. Transplants that combine newly-isolated nanofat, which has a rich stromal vascular fraction (SVF), with PRF and autologous structural fat granules may therefore be a safe, highly-effective, and long-lasting method for remodeling facial contours and rejuvenating the skin. PMID:28978136

Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review

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Prasetyo, Adri D; Prager, Welf; Rubin, Mark G; Moretti, Ernesto A; Nikolis, Andreas

2016-01-01

Background Cohesive monophasic polydensified fillers show unique viscoelastic properties and variable density of hyaluronic acid, allowing for a homogeneous tissue integration and distribution of the material. Objective The aim of this paper was to review the clinical data regarding the performance, tolerability, and safety of the Belotero® fillers for soft-tissue augmentation and rejuvenation. Methods A literature search was performed up until May 31, 2015 to identify all relevant articles on Belotero® fillers (Basic/Balance, Hydro, Soft, Intense, Volume) and equivalent products (Esthélis®, Mesolis®, Fortélis®, Modélis®). Results This comprehensive review included 26 papers. Findings from three randomized controlled trials showed a greater reduction in nasolabial fold severity with Belotero® Basic/Balance than with collagen (at 8, 12, 16, and 24 weeks, n=118) and Restylane® (at 4 weeks, n=40), and higher patient satisfaction with Belotero® Intense than with Perlane® (at 2 weeks, n=20). With Belotero® Basic/Balance, an improvement of at least 1 point on the severity scale can be expected in ~80% of patients 1–6 months after injection, with an effect still visible at 8–12 months. Positive findings were also reported with Belotero® Volume (no reduction in hyaluronic acid volume at 12 months, as demonstrated by magnetic resonance imaging), Soft (improvement in the esthetic outcomes when used in a sequential approach), and Hydro (improvement in skin appearance in all patients). The most common adverse effects were mild-to-moderate erythema, edema, and hematoma, most of which were temporary. There were no reports of Tyndall effect, nodules, granulomas, or tissue necrosis. Conclusion Clinical evidence indicates sustainable esthetic effects, good safety profile, and long-term tolerability of the Belotero® fillers, particularly Belotero® Basic/Balance and Intense. PMID:27660479

H2O2 rejuvenation-mediated synthesis of stable mixed-morphology Ag3PO4 photocatalysts

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Henry Agbe

2018-04-01

Full Text Available Ag3PO4 photocatalyst has attracted interest of the scientific community in recent times due to its reported high efficiency for water oxidation and dye degradation. However, Ag3PO4 photo-corrodes if electron accepter such as AgNO3 is not used as scavenger. Synthesis of efficient Ag3PO4 followed by a simple protocol for regeneration of the photocatalyst is therefore a prerequisite for practical application. Herein, we present a facile method for the synthesis of a highly efficient Ag3PO4, whose photocatalytic efficiency was demonstrated using 3 different organic dyes: Methylene Blue (MB, Methyl orange (MO and Rhodamine B (RhB organic dyes for degradation tests. Approximately, 19 % of Ag3PO4 is converted to Ag0 after 4.30 hours of continuous UV-Vis irradiation in presence of MB organic dye. We have shown that the Ag/Ag3PO4 composite can be rejuvenated by a simple chemical oxidation step after several cycles of photocatalysis tests. At an optimal pH of 6.5, a mixture of cubic, rhombic dodecahedron, nanosphere and nanocrystals morphologies of the photocatalyst was formed. H2O2 served as the chemical oxidant to re-insert the surface metallic Ag into the Ag3PO4 photocatalyst but also as the agent that can control morphology of the regenerated as-prepared photocatalyst without the need for any other morphology controlling Agent (MCA. Surprisingly, the as- regenerated Ag3PO4 was found to have higher photocatalytic reactivity than the freshly made material and superior at least 17 times in comparison with the conventional Degussa TiO2, and some of TiO2 composites tested in this work. Keywords: Materials chemistry, Materials science, Engineering

NGC 404: A REJUVENATED LENTICULAR GALAXY ON A MERGER-INDUCED, BLUEWARD EXCURSION INTO THE GREEN VALLEY

International Nuclear Information System (INIS)

Thilker, David A.; Bianchi, Luciana; Schiminovich, David; Gil de Paz, Armando; Seibert, Mark; Madore, Barry F.; Wyder, Ted; Barlow, Tom; Conrow, Tim; Forster, Karl; Friedman, Peter; Martin, Chris; Morrissey, Patrick; Small, Todd; Rich, R. Michael; Yi, Sukyoung; Neff, Susan

2010-01-01

We have discovered recent star formation in the outermost portion ((1-4) x R 25 ) of the nearby lenticular (S0) galaxy NGC 404 using Galaxy Evolution Explorer UV imaging. FUV-bright sources are strongly concentrated within the galaxy's H I ring (formed by a merger event according to del RIo et al.), even though the average gas density is dynamically subcritical. Archival Hubble Space Telescope imaging reveals resolved upper main-sequence stars and conclusively demonstrates that the UV light originates from recent star formation activity. We present FUV, NUV radial surface brightness profiles, and integrated magnitudes for NGC 404. Within the ring, the average star formation rate (SFR) surface density (Σ SFR ) is ∼2.2 x 10 -5 M sun yr -1 kpc -2 . Of the total FUV flux, 70% comes from the H I ring which is forming stars at a rate of 2.5 x 10 -3 M sun yr -1 . The gas consumption timescale, assuming a constant SFR and no gas recycling, is several times the age of the universe. In the context of the UV-optical galaxy color-magnitude diagram, the presence of the star-forming H I ring places NGC 404 in the green valley separating the red and blue sequences. The rejuvenated lenticular galaxy has experienced a merger-induced, disk-building excursion away from the red sequence toward bluer colors, where it may evolve quiescently or (if appropriately triggered) experience a burst capable of placing it on the blue/star-forming sequence for up to ∼1 Gyr. The green valley galaxy population is heterogeneous, with most systems transitioning from blue to red but others evolving in the opposite sense due to acquisition of fresh gas through various channels.

Triassic rejuvenation of unexposed Archean-Paleoproterozoic deep crust beneath the western Cathaysia block, South China

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Li, Xi-Yao; Zheng, Jian-Ping; Xiong, Qing; Zhou, Xiang; Xiang, Lu

2018-01-01

Jurassic (ca. 150 Ma) Daoxian basalts from the western Cathaysia block (South China) entrained a suite of deep-seated crustal xenoliths, including felsic schist, gneiss and granulite, and mafic two-pyroxene granulite and metagabbro. Zircon U-Pb-Hf isotopic, whole-rock elemental and Sr-Nd-Pb isotopic compositions have been determined for these valuable xenoliths to reveal the poorly-known, unexposed deep crust beneath South China. Detrital zircons from the garnet-biotite schists show several populations of ages at 0.65-0.5 Ga, 1.1-0.75 Ga, 1.6-1.4 Ga, 1.8-1.7 Ga, 2.5-2.4 Ga, 2.8 Ga, and 3.5 Ga, representing a multi-sourced, meta-sedimentary origin with deposition time at the early Cambrian. One mafic granulite contains zircons with concordant U-Pb ages of Neoarchean ( 2520 Ma), as well as Hf model ages of 2.8-2.6 Ga and positive εHf(t) values (up to 6.3), suggesting an accretion of juvenile crust in Neoarchean, probably as the main framework of the lower crust. Geochemical and geochronological evidence shows the mafic granulite and metagabbro were produced by underplating of magmas derived from the depleted asthenosphere and mixed with EM2-type materials during the Late Triassic (205-196 Ma). This magmatic underplating also resulted in the widespread metamorphism of the mafic lower crust and felsic middle crust (e.g., the felsic granulite and gneiss) at 202-201 Ma. We suggest the existence of a highly evolved Archean-Paleoproterozoic basement beneath the western Cathaysia block, which experienced episodic accretion and reworking and the strong rejuvenation during the Triassic. A three-layered structure of the lower crust could exist beneath the Daoxian area during the Jurassic time: its upper layer is an evolved Archean-Paleoproterozoic basement; the middle hybrid layer represents a mixture of Archean-Paleoproterozoic basement with newly accreted/reworked Proterozoic to Phanerozoic materials; and the deeper layer consists of mafic granulites derived from the

Enraizamento de estacas de erva-mate (Ilex paraguariensis A. St.-Hill. provenientes de brotações rejuvenescidas Rooting of "erva-mate" (Ilex paraguariensis A. St.-Hill. cuttings from rejuvenated sprouts

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J. Bitencourt

2009-01-01

the loss of rooting ability; thus, this paper aimed to verify the influence of rejuvenation and application of indolebutyric acid (IBA on the rooting of stem cuttings from "erva-mate". Cuttings were obtained using sprouts of the year from 13-year-old trees and rejuvenated sprouts from stump regrowth of 17-year-old trees. Cuttings were treated with IBA solution at the following concentrations: 0, 1500, 300, 4500 and 6000 mg L-1, resulting in 5 treatments for each cutting type. Planting was done in plastic containers filled with vermiculite and carbonized rice bark at 1:1 proportion. After 90 days in greenhouse, cuttings were evaluated for the following variables: percentage of cuttings with roots, number of roots/cutting, length of the three largest roots/cutting, and percentage of live cuttings, those with callus and dead ones. Statistical analysis indicated that the rejuvenated material had the best results concerning percentage of cuttings with root, and number and length of roots. The application of synthetic auxin did not influence the rooting of cuttings from neither type, so that IBA treatments did not differ statistically.

The effect of prefreeze rejuvenation on postthaw storage of red blood cells in AS-3 and SAGM.

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Lelkens, Charles C M; Lagerberg, Johan W M; de Korte, Dirk

2017-06-01

We investigated whether improving the metabolic status of red blood cell concentrates before freezing could extend the postthaw shelf life beyond 14 days while still meeting the requirements for hemolysis (0.8%) and total adenylate (>82% of original values). At Day 8 after collection, four leukoreduced red blood cell concentrates in saline-adenine-glucose-mannitol (SAGM) were pooled, mixed, and split (n = 4). Of these concentrates, two were rejuvenated in Rejuvesol. In addition, two leukoreduced red blood cell concentrates in phosphate-adenine-glucose-guanosine-gluconate-mannitol (PAGGGM) were pooled, mixed, and split at Day 8 after collection (n = 4). All concentrates were glycerolized, frozen, and stored for at least 2 weeks at -80°C. After thawing and deglycerolization, from each pair, one red blood cell concentrate was resuspended in SAGM, and one was suspended in AS-3. During postthaw storage at 2 to 6°C for 35 days, all concentrates were sampled weekly and analyzed for hematologic, metabolic, and morphologic parameters. Both Rejuvesol and PAGGGM treatment produced increased adenosine triphosphate and total adenylate and 2,3-diphosphoglycerate levels compared with untreated red blood cell concentrates. Regardless of prefreeze Rejuvesol or PAGGGM treatment, postthaw hemolysis remained below 0.8% during 7 days in SAGM and during 35 days in AS-3. At Day 35 of postthaw storage in AS-3, total adenylate in nonrejuvenated red blood cell concentrates had decreased to 72% of the original values; whereas, in prefreeze Rejuvesol-treated and PAGGGM-treated concentrates, adenylate values were still were at 101% and 98%, respectively. Based on maximum allowable hemolysis of 0.8% and total adenylate content greater than 82% of the original value, thawed, prefreeze Rejuvesol-treated or PAGGGM-treated red blood cell concentrates can be stored for 35 days at 2 to 6ºC in AS-3. © 2017 AABB.

Two years' outcome of thread lifting with absorbable barbed PDO threads: Innovative score for objective and subjective assessment.

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Ali, Yasser Helmy

2018-02-01

Thread-lifting rejuvenation procedures have evolved again, with the development of absorbable threads. Although they have gained popularity among plastic surgeons and dermatologists, very few articles have been written in literature about absorbable threads. This study aims to evaluate two years' outcome of thread lifting using absorbable barbed threads for facial rejuvenation. Prospective comparative stud both objectively and subjectively and follow-up assessment for 24 months. Thread lifting for face rejuvenation has significant long-lasting effects that include skin lifting from 3-10 mm and high degree of patients' satisfaction with less incidence rate of complications, about 4.8%. Augmented results are obtained when thread lifting is combined with other lifting and rejuvenation modalities. Significant facial rejuvenation is achieved by thread lifting and highly augmented results are observed when they are combined with Botox, fillers, and/or platelet rich plasma (PRP) rejuvenations.

Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro.

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Griffiths, Sarah; Baraniak, Priya R; Copland, Ian B; Nerem, Robert M; McDevitt, Todd C

2013-12-01

Multipotent mesenchymal stromal cells (MSCs) are clinically useful because of their immunomodulatory and regenerative properties, but MSC therapies are limited by the loss of self-renewal and cell plasticity associated with ex vivo expansion culture and, on transplantation, increased immunogenicity from xenogen exposure during culture. Recently, pooled human platelet lysate (hPL) has been used as a culture supplement to promote MSC growth; however, the effects of hPL on MSCs after fetal bovine serum (FBS) exposure remain unknown. MSCs were cultured in medium containing FBS or hPL for up to 16 passages, and cell size, doubling time and immunophenotype were determined. MSC senescence was assessed by means of a fluorometric assay for endogenous β-galactosidase expression. MSCs cultured with FBS for different numbers of passages were switched to hPL conditions to evaluate the ability of hPL to "rescue" the proliferative capacity of MSCs. hPL culture resulted in more rapid cell proliferation at earlier passages (passage 5 or earlier) than remove FBS; by day 4, hPL (5%) yielded an MSC doubling time of 1.28 days compared with 1.52 days in 16% FBS. MSCs cultured first in FBS and switched to hPL proliferated more and demonstrated less β-galactosidase production and smaller cell sizes than remove MSCs continuously propagated in FBS. hPL enables rapid expansion of MSCs without adversely affecting immunophenotype. hPL culture of aged and senescent MSCs demonstrated cellular rejuvenation, reflected by decreased doubling time and smaller cell size. These results suggest that expansion of MSCs in hPL after FBS exposure can enhance cell phenotype and proliferative capacity. Copyright © 2013 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Comparison of efficacy of chemical peeling with 25% trichloroacetic acid and 0.1% retinoic acid for facial rejuvenation

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Selda Yildirim

2016-06-01

Full Text Available Introduction : Skin aging is a problem which negatively affects the psyche of the person, social relations, as well as work life and health and which compels the patients to find appropriate treatment methods. Numerous treatment methods have been developed in order to delay aging and to reduce the aging effects in addition to having a younger, healthier and more beautiful facial appearance. Aim : To compare the efficiency, cosmetic results and possible adverse effects of the peeling treatment with 25% trichloroacetic acid (TCA and 0.1% retinoic acid for facial rejuvenation in patients presenting with skin aging. Material and methods: Fifty female patients in total presenting with medium and advanced degree skin aging were subject to this study. Two separate treatment groups were formed; the first group underwent chemical skin treatment with 25% TCA while the other group was applied with 0.1% retinoic acid treatment. Following the 4 months’ treatment the patients were controlled three times in total for post lesional hypopigmentation, hyperpigmentation, scars, skin irritation and other possible changes per month. The pretreatment and first follow-up visit, and final control images were comparatively evaluated by three observers via specific software. Results : The healing rates of the group subject to retinoic acid were statistically higher (p 0.05. The frequency of TCA- and retinoic acid-associated adverse effects was similar in both groups (p > 0.05. As a result of both treatments, a reduction in the quality of life scores as well as a pronounced recovery (p = 0.001 in the quality of life of those patients with skin aging was observed. Conclusions : The photo aging treatment option with 0.1% retinoic acid is cheaper and more feasible for patients compared to 25% TCA, and it is also as reliable and effective as TCA.

Rejuvenecimiento de manos con ácido hialurónico de alta densidad: estudio prospectivo en 29 pacientes Hands rejuvenation with high density hyaluronic acid: prospective study in 29 patients

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J.M. Alcolea

2012-12-01

hyaluronic acid (HA subcutaneous injection, Macrolane® 20, in hand rejuvenation in the short, medium and long term, regarding treatment benefit, patient satisfaction and possible complications. This study was performed between May 2010 and December 2011. Twenty nine patients were enrolled at random, aged from 51 to 74, phototypes II-IV, and were treated with HA for hand rejuvenation. A clinical follow-up was performed at 2 weeks, and 1, 3, 6, 9 and 12th months after. The quantity of HA injected for each hand was 1-2 ml. Complications were recorded at each control. Ecographic exam was carried out at the first control 2 weeks after treatment in order to determine if a second injection was necessary. Patients answered a satisfaction questionnaire at every control. Only 1 patient presented edema and 3 patients suffered slight ecchymosis. Two patients expressed slight pain with injections and 2 patients needed a second injection after the assessment 2 weeks after. Patients´ satisfaction was higher than clinical and photographic assessment. In our opinion, hand rejuvenation has a low rate of complications with these large-sized particles HA, and it has been well tolerated with a high patient satisfaction and outstanding improvement with respect to: wrinkles, dermal and subcutaneous atrophy and decrease of bony, sinewy and venous prominences. The subjective and objective assessment achieved a good result one year later.

Evaluation of bio-materials’ rejuvenating effect on binders for high-reclaimed asphalt content mixtures; Evaluación del efecto rejuvenecedor de bio-materiales sobre ligantes para mezclas con alto contenido de asfalto recuperado

Energy Technology Data Exchange (ETDEWEB)

Jiménez del Barco-Carrión, A.; Pérez-Martínez, M.; Themeli, A.; Lo Presti, D.; Marsac, P.; Pouget, S.; Hammoum, F.; Chailleux, E.; Airey, G.D.

2017-07-01

The interest in using bio-materials in pavement engineering has grown significantly over the last decades due to environmental concerns about the use of non-recoverable natural resources. In this paper, bio-materials are used together with Reclaimed Asphalt (RA) to restore some of the properties of the aged bitumen present in mixtures with high RA content. For this purpose, two bio-materials are studied and compared to conventional and polymer modified bitumens. Blends of these materials with RA bitumen were produced and studied to simulate a 50% RA mixture. The rejuvenating effect of the two bio-materials on RA has been assessed and compared with the effect of the conventional binders. Apparent Molecular Weight Distribution of the samples (obtained by the ?-method) and different rheological parameters were used for this purpose. Results revealed the power of bio-materials to rejuvenate RA bitumen, showing their capability to be used as fresh binders in high-RA content mixtures. [Spanish] El interés en la utilización de bio-materiales en ingeniería de pavimentos ha crecido significantemente en las últimas décadas debido a la conciencia ambiental sobre el uso de recursos naturales no renovables. En este artículo, se utilizan bio-materiales para recuperar las propiedades iniciales del betún envejecido presente en mezclas con alto contenido de asfalto reciclado (RA). Para ello, se ha estudiado y comparado el comportamiento de dos bio-materiales con betunes convencionales y betunes modificados con polímeros. Con este objetivo, se fabricaron mezclas de bio-materiales y betún reciclado simulando mezclas asfálticas con 50% de contenido de reciclado. El efecto rejuvenecedor de los bio-materiales se ha evaluado y comparado con el efecto rejuvenecedor de ligantes convencionales mediante el cálculo de las distribuciones de peso molecular aparente y diferentes pará-metro reológicos. Los resultados muestran el poder rejuvenecedor de los bio-materiales, poniendo de

Mesotherapy with an Intradermal Hyaluronic Acid Formulation for Skin Rejuvenation: An Intrapatient, Placebo-Controlled, Long-Term Trial Using High-Frequency Ultrasound.

Science.gov (United States)

Tedeschi, Aurora; Lacarrubba, Francesco; Micali, Giuseppe

2015-02-01

Mesotherapy with hyaluronic acid (HA) is a treatment approach currently used for skin rejuvenation. High-frequency ultrasound (20-100 MHz) is a non-invasive technique that has been used to evaluate age-related dermal changes. The presence and the degree of a typical subepidermal low-echogenic band (SLEB) are photoaging related: the lower the SLEB echogenicity, the higher the photoaging. The aim of this trial was to evaluate, through ultrasound imaging, the long-term effects of microinjections of HA on SLEB echogenicity. Twenty-two women with clinical and ultrasound signs of moderate photoaging were enrolled in the study. Treatment consisted of multiple microinjections of HA salts of biotechnological origin on the dorsum of one hand, once weekly for 4 weeks and, successively, once monthly for 4 months (group A) or 9 months (group B). The dorsum of the other hand of each subject was injected with saline solution and used as a control. In all subjects, high-frequency ultrasound (22 MHz) was performed to evaluate SLEB echogenicity changes during treatment. Eighteen out of 22 patients completed the study. At the end of 4 weeks, an ultrasound increase of dermal echogenicity was observed in 13 subjects (seven of group A and six of group B), which we considered as "responders". In these patients, the Student's t-test showed a significant increase from baseline of SLEB pixel numbers of +24 % (P mesotherapy with HA may effectively improve skin aging and photoaging, as supported by quantifiable ultrasound data showing significant changes in SLEB density over time.

Potential role of S100A8 in skin rejuvenation with the 1064-nm Q-switched Nd:YAG laser.

Science.gov (United States)

Qin, Yan; Qin, Xiaofeng; Xu, Peng; Zhi, Yuanting; Xia, Weili; Dang, Yongyan; Gu, Jun; Ye, Xiyun

2018-04-01

The 1064-nm Q-switched Nd:YAG laser is demonstrated to be effective for non-ablative skin rejuvenation, but the molecular mechanism by which dermis responses to laser-induced damage and initiates skin remodeling is still unclear. HaCaT cells and 3T3 skin fibroblasts were irradiated with the 1064-nm Q-switched Nd:YAG laser at the different doses. Then, cells were collected and lysed for PCR and Western blot analysis. Cell viability was detected by Cell Counting Kit-8 (CCK-8) before and after laser irradiation. The expressions of S100A8, advanced glycosylation end product-specific receptor (RAGE) and inflammatory cytokines in two cell lines were markedly upregulated after laser treatments. The PCR, Western blot, and ELISA analysis showed the significant increase of type I and III procollagen in the 3T3 cells treated with the 1064-nm laser. Interestingly, si S100A8 effectively inhibited the expression of cytokines and collagen, while S100A8 treatments significantly increased them. P-p38 and p-p65 levels were also elevated after the 1064-nm laser irradiation, which is positively related with S100A8. Cell viability and reactive oxygen species (ROS) levels were not changed, while the content of superoxidase dismutase (SOD) in two cells was increased after laser irradiation. Our results demonstrated that the overexpression of S100A8 induced by the 1064-nm laser irradiation triggered inflammatory reactions in skin cells. The inflammatory microenvironment and improvement of skin antioxidant capacity contribute to new collagen synthesis in the skin cells. Thus, S100A8 was required for laser-induced new collagen synthesis in skin cells. p38/MAPK and NF-κB signal pathways were involved in S100A8-mediated inflammatory reactions in response to laser irradiation.

Midfacial rejuvenation via a minimal-incision brow-lift approach: critical evaluation of a 5-year experience.

Science.gov (United States)

Williams, Edwin F; Vargas, Hannah; Dahiya, Ravinder; Hove, Christopher R; Rodgers, Bret J; Lam, Samuel M

2003-01-01

unilateral cranial nerve V2 paresthesia. Five patients had alopecia requiring scar revision. Many of these complications, including subperiosteal abscess and alopecia, have subsequently been avoided by minor technique modifications. The technique of midface-lift via transbrow approach is a safe, reliable method of midfacial rejuvenation and avoids the unnatural lateral-canthal distortion previously described in the literature.

Comparison of renewable oil, recycled oil, and commercial rejuvenating agent derived from crude oil in paving asphalt modification[Includes the CSCE forum on professional practice and career development : 1. international engineering mechanics and materials specialty conference : 1. international/3. coastal, estuarine and offshore engineering specialty conference : 2. international/8. construction specialty conference

Energy Technology Data Exchange (ETDEWEB)

Gordon, C.; Ho, S.; Zanzotto, L. [Calgary Univ., AB (Canada). Schulich School of Engineering

2009-07-01

The asphalt industry relies heavily on crude oil. In response to increasing oil prices, there have been efforts to save money on asphalt by taking harder asphalts, such as recycled asphalt pavement (RAP), and softening them with rejuvenating agents. For asphalt that is to be used in cold climates, softer asphalts are preferred because they will perform better under extreme cold conditions without cracking. This study compared the performance, economic benefits, and environmental benefits of renewable materials, recycled oil and a commercially used rejuvenating agent derived from crude oil. Different oily materials including margarine, Cyclogen L (a crude oil-derived material), a vegetable wax, and recycled cooking oil were used to modify paving asphalt. Their effectiveness at improving the superpave low-temperature performance grade was compared. The samples were all tested using the 2008 AASHTO M320 procedures. The high temperature grades were determined using the dynamic shear rheometer test, and the low-temperature grades were determined using the bending beam rheometer test. The 3 varieties of margarine that were tested were able to improve the low-temperature grade, but they caused a greater depreciation of the high-temperature performance grade than the other materials, and were much more expensive. The best candidate for an effective, economic asphalt softening agent was found to be the recycled cooking oil. It out-performed the Cyclogen L oil in terms of improving the low- temperature performance grade, and was less expensive. 12 refs., 4 tabs., 6 figs.

Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review

Directory of Open Access Journals (Sweden)

Prasetyo AD

2016-09-01

Full Text Available Adri D Prasetyo,1 Welf Prager,2 Mark G Rubin,3 Ernesto A Moretti,4 Andreas Nikolis5 1Rejuva Skin & Beauty, Surabaya, Indonesia; 2Prager & Partner, Hamburg, Germany; 3University of California, San Diego, CA, USA; 4Gamma Health Group, Sanatorio Los Arroyos, Santa Fe, Republic of Argentina; 5Victoria Park Clinical Research Centre, Westmount, QC, Canada Background: Cohesive monophasic polydensified fillers show unique viscoelastic properties and variable density of hyaluronic acid, allowing for a homogeneous tissue integration and distribution of the material.Objective: The aim of this paper was to review the clinical data regarding the performance, tolerability, and safety of the Belotero® fillers for soft-tissue augmentation and rejuvenation.Methods: A literature search was performed up until May 31, 2015 to identify all relevant articles on Belotero® fillers (Basic/Balance, Hydro, Soft, Intense, Volume and equivalent products (Esthélis®, Mesolis®, Fortélis®, Modélis®.Results: This comprehensive review included 26 papers. Findings from three randomized controlled trials showed a greater reduction in nasolabial fold severity with Belotero® Basic/Balance than with collagen (at 8, 12, 16, and 24 weeks, n=118 and Restylane® (at 4 weeks, n=40, and higher patient satisfaction with Belotero® Intense than with Perlane® (at 2 weeks, n=20. With Belotero® Basic/Balance, an improvement of at least 1 point on the severity scale can be expected in ~80% of patients 1–6 months after injection, with an effect still visible at 8–12 months. Positive findings were also reported with Belotero® Volume (no reduction in hyaluronic acid volume at 12 months, as demonstrated by magnetic resonance imaging, Soft (improvement in the esthetic outcomes when used in a sequential approach, and Hydro (improvement in skin appearance in all patients. The most common adverse effects were mild-to-moderate erythema, edema, and hematoma, most of which were

5 Ma of plume source evolution in the Niihau - Kauai - North Arch magmas, Hawaii

Science.gov (United States)

Beguelin, P.; Bizimis, M.; McIntosh, E. C.; Cousens, B.; Clague, D. A.

2017-12-01

The Hawaiian islands of Kauai, Niihau and Kaula form a 200 km wide platform across the plume track and record the longest activity record of Hawaiian volcanism ( > 5Ma) [1]. We present new Hf and high precision Pb (MC-ICP-MS with Tl addition) isotope data on 56 previously characterized [2] shield, post-shield and rejuvenated stage lavas from Kauai and Niihau, and on rejuvenated lavas from the North Arch volcanic field, 250 km NE of Kauai. These samples cover nearly the full eruptive history of Kauai and Niihau, and complete an across-plume transect of rejuvenated volcanism, along with published Kaula values [3]. In Nd-Hf-Sr-Pb isotope spaces [2], shield and post-shield lavas from Kauai and Niihau partially overlap the Koolau shield lavas (KSDP, Oahu [4]). Rejuvenated lavas from Kauai and Niihau show a 3 ɛNd units variability and overlap North Arch at a common depleted composition at ɛNd 9 and ɛHf 14. Kauai rejuvenated lavas in part overlap shield and post-shield lavas in Nd-Hf, but extend to lower ɛHf values for a given 87Sr/86Sr and ɛNd. In contrast Niihau rejuvenated lavas have higher ɛHf for a given ɛNd and 87Sr/86Sr compared to all Hawaiian shield lavas. The Niihau data cannot be explained by contribution of a proximal shield stage plume source (e.g. Niihau or Kauai). Instead it is consistent with mixing between a depleted mantle source and an enriched component with high Nd/Hf, Sr/Hf ratios, akin to a carbonatite with low ɛHf and ɛNd, and with their trace element systematics [5] . ICP-MS Pb isotope data for rejuvenated lavas from Kaula, Niihau, Kauai, and North Arch form three distinct arrays, confirming heterogeneity in the rejuvenated source. Our data is consistent with the presence of an enriched, Koolau-like component in the source of shield, post-shield and rejuvenated volcanism in Kauai and Niihau. The rejuvenated sources are heterogeneous across the plume, with the most isotopically depleted values seen in the distal North Arch volcanic field

The Effect of Aging on the Cracking Resistance of Recycled Asphalt

Directory of Open Access Journals (Sweden)

Mojtaba Mohammadafzali

2017-01-01

Full Text Available Fatigue cracking is an important concern when a high percentage of Reclaimed Asphalt Pavement (RAP is used in an asphalt mixture. The aging of the asphalt binder reduces its ductility and makes the pavement more susceptible to cracking. Rejuvenators are often added to high-RAP mixtures to enhance their performance. The aging of a rejuvenated binder is different from virgin asphalt. Therefore, the effect of aging on a recycled asphalt mixture can be different from its effect on a new one. This study evaluated the cracking resistance of 100% recycled asphalt binders and mixtures and investigated the effect of aging on this performance parameter. The cracking resistance of the binder samples was tested by a Bending Beam Rheometer. An accelerated pavement weathering system was used to age the asphalt mixtures and their cracking resistance was evaluated by the Texas Overlay Test. The results from binder and mixture tests mutually indicated that rejuvenated asphalt has a significantly better cracking resistance than virgin asphalt. Rejuvenated mixtures generally aged more rapidly, and the rate of aging was different for different rejuvenators.

The effects of platelet-rich plasma on recovery time and aesthetic outcome in facial rejuvenation: preliminary retrospective observations.

Science.gov (United States)

Willemsen, Joep C N; van der Lei, Berend; Vermeulen, Karin M; Stevens, Hieronymus P J D

2014-10-01

This study focused on the possible effect of platelet-rich plasma (PRP) on recovery time and aesthetic outcome after facial rejuvenation. We conducted a retrospective analysis with regard to recovery time and the aesthetic improvement after treatment among four groups of patients: those treated with fat grafting only (Group I), those treated with fat grafting and PRP (Group II), those treated with a minimal access cranial suspension (MACS)-lift and fat grafting (Group III), and those treated with a MACS-lift, fat grafting, and PRP (Group IV). For the first part of this study, i.e., evaluation of recovery time after surgery, the following selection criteria were used: nonsmoking females, aged 35-65 years, with a complete documented follow-up. In total, 82 patients were included in the evaluation of patient-reported recovery time. For the second part of the study, i.e., evaluation of potential differences in aesthetic outcome, the records of these 82 patients were screened for the presence of pre- and postoperative standardized photographs in three views (AP, lateral, and oblique), leaving 37 patients to evaluate. A questionnaire was developed to evaluate the aesthetic outcome in all four groups of patients. This questionnaire was given to an expert panel that consisted of ten plastic surgeons. The addition of PRP to a lipofilling procedure resulted in a significant drop in the number of days needed to recover before returning to work or to restart social activities [Group I (no PRP) took 18.9 days vs Group II (PRP) took 13.2 days, p = 0.019]. There seemed to be no effect when PRP was added to a MACS-lift + lipofilling procedure. Also, the aesthetic outcome of the lipofilling and MACS-lift + lipofilling groups that received PRP (Groups II and IV) was significantly better than the groups without PRP (Groups I and III). Adding PRP to facial lipofilling reduces recovery time and improves the overall aesthetic outcome of a MACS-lift. This journal requires that

Update on botulinum toxin and dermal fillers.

Science.gov (United States)

Berbos, Zachary J; Lipham, William J

2010-09-01

The art and science of facial rejuvenation is an ever-evolving field of medicine, as evidenced by the continual development of new surgical and nonsurgical treatment modalities. Over the past 10 years, the use of botulinum toxin and dermal fillers for aesthetic purposes has risen sharply. Herein, we discuss properties of several commonly used injectable products and provide basic instruction for their use toward the goal of achieving facial rejuvenation. The demand for nonsurgical injection-based facial rejuvenation products has risen enormously in recent years. Used independently or concurrently, botulinum toxin and dermal filler agents offer an affordable, minimally invasive approach to facial rejuvenation. Botulinum toxin and dermal fillers can be used to diminish facial rhytides, restore facial volume, and sculpt facial contours, thereby achieving an aesthetically pleasing, youthful facial appearance.

Polarization imprint effects on the photovoltaic effect in Pb(Zr,Ti)O3 thin films

Science.gov (United States)

Tan, Zhengwei; Tian, Junjiang; Fan, Zhen; Lu, Zengxing; Zhang, Luyong; Zheng, Dongfeng; Wang, Yadong; Chen, Deyang; Qin, Minghui; Zeng, Min; Lu, Xubing; Gao, Xingsen; Liu, Jun-Ming

2018-04-01

The polarization imprint along with the photovoltaic (PV) effect has been studied in Pt/Pb(Zr0.3Ti0.7)O3/SrRuO3 ferroelectric capacitors. It is shown that the positive DC poling induces the imprint with a downward direction whereas the negative DC poling suppresses the imprint (i.e., rejuvenation). In the polarization up state, the imprinted capacitor exhibits degraded PV properties compared with the rejuvenated one. This may be because the imprint reduces the number of upward domains, thus lowering the driving force for the PV effect. In the polarization down state, however, the rejuvenated capacitor enters the imprinted state spontaneously. This rejuvenation-to-imprint transition can be further aggravated by applying positive voltages and ultraviolet illumination. It is proposed that the domain pinning/depinning, which are associated with the oxygen vacancies and trapped electrons modulated by polarization, voltage, and illumination, may be responsible for the polarization imprint and rejuvenation. Our study therefore sheds light on the correlation between the polarization imprint and the PV effect in the ferroelectrics and also provides some viable suggestions to address the imprint-induced degradation of PV performance.

Incorporating the transverse profile of the wearing course into the control of the hot in-place recycling of asphalt concrete

Science.gov (United States)

Makowska, Michalina; Huuskonen-Snicker, Eeva; Alanaatu, Pauli; Aromaa, Kalle; Savarnya, Abhishek; Pellinen, Terhi; Das, Animesh

2018-05-01

The hot in-place recycling (HIR) of asphalt concrete (AC) is one of the least CO2 emissive reuse techniques. It allows for 100% reuse of material in-situ in the same application, at a reduced need for the material transport to and back from the construction site, as well as the reduced price in comparison with the fresh wearing course overlay. Finland uses the technique predominantly to fill wheel path ruts caused by the studded tire abrasion, to retain structural capacity and prevent hydroplaning. During the HIR process, the aged AC material is heated up in-situ, milled to the approximate depth of 40 mm, blended with fresh AC admixture and rejuvenator. However, the amount of the aged material and the amount of the aged bitumen that undergoes rejuvenation depends on the pavement transverse profile. The rut depth, width and shape determine the minimum volume of admixture necessary for refill during the process in order to retain the structural capacity, as well as the amount of the aged binder requiring rejuvenation. In favor of achieving homogenous rheological properties in the final product, the proportion between the aged binder and the fresh binder should be controlled, as it influences the required amount of rejuvenator. Therefore, the rut cross-sectional area and furthermore, the rut volume is one of the previously unrecognized or ignored major variables of the hot in-place recycling process in Finland that should be incorporated to the HIR process control. This article demonstrates the methodology of incorporating the transverse road profile measurements by 17 vehicle-mounted laser sensors into the calculation of required rejuvenator amounts. This can be done during the procurement preparation phase or during the paving work as a continuous in-situ process control. In the rheological optimization the apparent Newtonian viscosity concept and the rotational viscosity are utilized in the viscosity based blending equation, which then allows the use of oily

The Addition of Platelet-Rich Plasma to Facial Lipofilling : A Double-Blind, Placebo-Controlled, Randomized Trial

NARCIS (Netherlands)

Willemsen, Joep C. N.; Van Dongen, Joris; Spiekman, Maroesjka; Vermeulen, Karin M.; Harmsen, Martin C.; van der Lei, Berend; Stevens, H. P. Jeroen

Background: Lipofilling is a treatment modality to restore tissue volume, but it may also rejuvenate the aging skin. Platelet-rich plasma has been reported to augment the efficacy of lipofilling, both on graft take and rejuvenation, by altering the adipose-derived stem cells. The authors

Rejuvenating CERN's Accelerators

CERN Multimedia

2004-01-01

In the coming years and especially in 2005, CERN's accelerators are going to receive an extensive renovation programme to ensure they will perform reliably and effectively when the LHC comes into service.

Mira B Rejuvenated

OpenAIRE

Wood, Brian E.; Karovska, Margarita

2006-01-01

Recent ultraviolet spectra from the Hubble Space Telescope (HST) and Far Ultraviolet Spectroscopic Explorer (FUSE) satellites demonstrate that UV line and continuum fluxes observed from Mira B are increasing back towards the levels that the International Ultraviolet Explorer observed in 1979-1980 and 1990-1995, after having been found in a very low state by HST and FUSE in 1999-2001. The UV emission is associated with accretion of material onto Mira B from Mira A's massive wind, so the variab...

CERN stationery rejuvenated

CERN Multimedia

Anaïs Schaeffer

2013-01-01

With the introduction of CERN’s new graphic charter, our complete range of official communications stationery has been redesigned. Discover the newly harmonised and standardised range of CERN stationery.   As the Director-General announced in Bulletin 41-42/2012, a new graphic charter is now in force at CERN. The graphics team has taken this opportunity to redesign all the official CERN stationery, such as business cards, correspondence cards, letterheads, envelopes and file holders, all of which will now boast the same, unified format. In keeping with CERN’s new graphic charter, even the business cards have had a makeover: of a better quality than their predecessors, they now elegantly display the CERN colours (namely the familiar Pantone 286 blue). These new cards, which all follow a standardised format, help to project a standardised corporate image of the Organization. Order them online now! As the Director-General highlighted, “it's increasingly imp...

Rejuvenecimiento facial en "doble sigma" "Double ogee" facial rejuvenation

Directory of Open Access Journals (Sweden)

O. M. Ramírez

2007-03-01

. Este arco conecta con la convexidad superior del tercio medio facial que se une con la concavidad de la porción inferior del tercio medio (arco inferior. Los paciente con un considerable envejecimiento y ptosis de las estructuras centrales faciales se pueden beneficiar en la mayoría de los casos de nuestro abordaje endoscópico. Las cejas, las comisuras de los párpados, de los tejidos blandos nasoglaberlares, los surcos nasolabiales, la nariz, las mejillas, el ángulo de la boca y los "jowls" (mejillas de bulldog se pueden tratar con eficacia mediante este abordaje. También las ojeras y los hundimientos orbitarios inferiores. Es eficaz también en ritidectomías secundarias o terciarias que requieren rejuvenecimiento cutáneo simultaneo y para cuando se precisa aumento de los tejidos blandos así como en las desproporciones esqueléticas y de los tejidos blandos. Las estructuras óseas expuestas pueden ser aumentadas o reducidas según convenga. Recomendamos este abordaje cuando hay que cambiar o extirpar implantes faciales aloplásticos. Los procedimientos endoscópicos de la frente y del tercio medio facial permiten la reconstrucción del "Doble Sigma" que se asocia a un aspecto juvenil.Subperiosteal techniques describes by Tessier have revolutionized the treatment of the aging face advocating this approach to treat early signs of aging in young and middleage patients. Psillakis refines the technique further and Ramirez describes a safer and more effective method of subperiosteal lifting, so that this technique could be applied across the full spectrum of facial aging. The introduction of the endoscope in the treatment of facial rejuvenation ushered in a new era in Aesthetic Surgery. Today, endoscopically assisted subperiosteal undermining of the upper, middle and lower face can provide a means for repositioning the sagging facial soft tissues in addition to augmentation of the craniofacial skeleton, with a reduced preoperative facial edema, minimal injury to the

Stem Cells and Aging.

Science.gov (United States)

Koliakos, George

2017-02-01

The article is a presentation at the 4th Conference of ESAAM, which took place on October 30-31, 2015, in Athens, Greece. Its purpose was not to cover all aspects of cellular aging but to share with the audience of the Conference, in a 15-minute presentation, current knowledge about the rejuvenating and repairing somatic stem cells that are distinct from other stem cell types (such as embryonic or induced pluripotent stem cells), emphasize that our body in old age cannot take advantage of these rejuvenating cells, and provide some examples of novel experimental stem cell applications in the field of rejuvenation and antiaging biomedical research.

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

Directory of Open Access Journals (Sweden)

Geraldine Gontier

2018-02-01

Full Text Available Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive. Here we report that the enzyme ten eleven translocation methylcytosine dioxygenase 2 (Tet2, which catalyzes the production of 5-hydroxymethylcytosine (5hmC, rescues age-related decline in adult neurogenesis and enhances cognition in mice. We detected a decrease in Tet2 expression and 5hmC levels in the aged hippocampus associated with adult neurogenesis. Mimicking an aged condition in young adults by abrogating Tet2 expression within the hippocampal neurogenic niche, or adult neural stem cells, decreased neurogenesis and impaired learning and memory. In a heterochronic parabiosis rejuvenation model, hippocampal Tet2 expression was restored. Overexpressing Tet2 in the hippocampal neurogenic niche of mature adults increased 5hmC associated with neurogenic processes, offset the precipitous age-related decline in neurogenesis, and enhanced learning and memory. Our data identify Tet2 as a key molecular mediator of neurogenic rejuvenation.

Biological conversion system

Science.gov (United States)

Scott, C.D.

A system for bioconversion of organic material comprises a primary bioreactor column wherein a biological active agent (zymomonas mobilis) converts the organic material (sugar) to a product (alcohol), a rejuvenator column wherein the biological activity of said biological active agent is enhanced, and means for circulating said biological active agent between said primary bioreactor column and said rejuvenator column.

Oxygeneo®-A Unique Three-in-one Treatment of Exfoliation, Infusion, and Oxygenation via the Bohr Effect and TriPollar™ Radiofrequency for Skin Rejuvenation.

Science.gov (United States)

Diaz, Deanna; Boonsiri, Metavee; Okawa, Joyce; Dekranes, Denise; Ditre, Chérie M

2017-11-01

optimal procedure that can be implemented in patients looking for noninvasive, safe, and effective rejuvenation treatments with no associated downtime post-procedure.

Oxygeneo®—A Unique Three-in-one Treatment of Exfoliation, Infusion, and Oxygenation via the Bohr Effect and TriPollar™ Radiofrequency for Skin Rejuvenation

Science.gov (United States)

Diaz, Deanna; Boonsiri, Metavee; Okawa, Joyce; Dekranes, Denise

2017-01-01

an optimal procedure that can be implemented in patients looking for noninvasive, safe, and effective rejuvenation treatments with no associated downtime post-procedure. PMID:29399257

Face expressive lifting (FEL): an original surgical concept combined with bipolar radiofrequency

OpenAIRE

Divaris, Marc; Blugerman, Guillermo; Paul, Malcolm D.

2013-01-01

Background Aging can lead to changes in facial expressions, transforming the positive youth expression of happiness to negative expressions as sadness, tiredness, and disgust. Local skin distension is another consequence of aging, which can be difficult to treat with rejuvenation procedures. The “face expressive lifting” (FEL) is an original concept in facial rejuvenation surgery. On the one hand, FEL integrates established convergent surgical techniques aiming to correct the age-related nega...

Anatomic and mechanical considerations in restoring volume of the face with use of hyaluronic acid fillers with a novel layered technique

OpenAIRE

Thomas, Mohan K.; Dsilva, James A.; Borole, Ateesh J.; Naik, Sudhir M.; Sarkar, Soma G.

2014-01-01

Context: Facial fillers have revolutionized the field of cosmetic facial rejuvenation as it has become the prime sought - after rejuvenation procedure offering youthful, 3-dimensional look with minimal invasiveness. Fillers are expensive and need to be redone periodically hence a sound understanding of structural basis on which they are laid is important in reducing the quantity of filler required in each sitting as well as increasing the longevity of results. Aim: The aim of the following st...

Anatomy of the jawline, neck, and perioral area with clinical correlations.

Science.gov (United States)

Agarwal, Anurag; Dejoseph, Louis; Silver, William

2005-02-01

The dramatic rise in the number of cosmetic procedures performed during the past 5 years reflects a heightened public awareness of and interest in facial rejuvenation. Concomitant with this rise has been the addition of new injectable fillers, lasers, and minimal incision techniques to the surgeon's armamentarium. Perhaps the greatest applicability of these modalities has been the rejuvenation of the perioral region, neck, and jawline, with reduced "downtime" but visible results. Signs of aging that are clearly visible in the lower third of the face include the loss of elasticity and descent of fat in the jowl region; laxity of the neck skin, muscle, and fat; development of perioral rhytids, deep nasolabial folds, and marionette lines; and the loss of definition of the lips. The purpose of this article is to highlight our approach to rejuvenation of these areas, elucidate the role of newer technologies, and provide special techniques and pearls utilized in rhytidectomy.

[Jugal rejuvenation and jowls treatment].

Science.gov (United States)

Fogli, A

2017-10-01

The aim of this study is to analyze the anatomical changes leading to the appearance of jugal aging with the appearance of jowls. It is also to describe the different techniques and to highlight those that are most effective with the permanent concern of obtaining a natural result with a well-defined jawline and a harmonious distribution of jugal volumes. For this purpose, the techniques of lifting with relocation of the displaced volumes and lipostructure are often associated with the strict respect of different directional vectors for the underlying tissues and for the skin redraping. More precisely, the dissection of the pre-masseteric space makes it possible to address the specific problems posed by the jowls and the heavy labio-mental grooves. In responding to the psycho-sociological demand of our time, two major types of indications emerge with the facelift of the young patient, which makes it possible to obtain a long lasting result and a fast return to social and professional life and a later indication surgery, which requires more invasive techniques resulting in heavier surgical procedures and follow-up. Copyright © 2017. Published by Elsevier Masson SAS.

Trace element evidence for a depleted component intrinsic to the Hawaiian plume

Science.gov (United States)

DeFelice, C.; Mallick, S.; Saal, A. E.; Huang, S.

2017-12-01

The Hawaii Scientific Drilling Project (HSDP) recovered 3.5 km of Mauna Kea post-shield and shield stage basalts to investigate the geochemical evolution of a Hawaiian shield stage volcano and to constrain the geochemical structure of Hawaiian plume. A group of tholeiitic lavas from 1760-1810 meters below sea level (mbsl) have higher CaO content at given MgO content and are called high-CaO basalts. Isotopes of Pb, Sr, Hf, and Nd of these basalts show they are the most depleted shield basalts ever recovered in Hawaii. Their 206Pb/204Pb-208Pb/204Pb values indicate that they are not related to Pacific MORB. Their Ba/Th values (115-160) are characteristic of Hawaiian plume material and they are isotopically similar to Hawaiian rejuvenated stage lavas. To further investigate this relationship, we compare high-CaO basalts to the Honolulu Volcanics, a set of rejuvenated stage lavas. To determine their possible petrogenetic relation, we calculate their parental melt composition by adding or removing olivine until their geochemical composition is in equilibrium with Fo90. The High-CaO basalt parent magma composition has a much flatter REE pattern and much lower absolute REE contents than that of the Honolulu lavas. Batch melting forward models are calculated to determine potential sources that could contribute to both the Honolulu Volcanics and high-CaO basalts petrogenesis. Both parental magma compositions can be recreated by melting the same rejuvenated-stage source composition to varying degrees. Honolulu Volcanics are the result of a low degree of melting of the rejuvenated source, while higher degrees of melting reproduce the high-CaO basalts. The High-CaO basalts, erupted during shield-stage volcanism, show that the depleted component that rejuvenated stage basalts form from can be sampled during the most voluminous stage of volcanism, and is likely intrinsic to the plume.

Fat Grafting for Facial Filling and Regeneration.

Science.gov (United States)

Coleman, Sydney R; Katzel, Evan B

2015-07-01

Plastic surgeons have come to realize that fat grafting can rejuvenate an aging face by restoring or creating fullness. However, fat grafting does much more than simply add volume. Grafted fat can transform or repair the tissues into which it is placed. Historically, surgeons have hesitated to embrace the rejuvenating potential of fat grafting because of poor graft take, fat necrosis, and inconsistent outcomes. This article describes fat grafting techniques and practices to assist readers in successful harvesting, processing, and placement of fat for optimal graft retention and facial esthetic outcomes. Copyright © 2015 Elsevier Inc. All rights reserved.

Comparison of 230Th/234U Dating Results Obtained on Fossil Mollusk Shell from Morocco and Fossil Coral Samples from Egypt. Research of Methodological Criteria to Valid the Measured Age

International Nuclear Information System (INIS)

Choukri, A.; Hakam, O.K.; Reyss, J.L.

2013-01-01

Radiochemical ages of 126 unrecrystallized coral samples from the Egyptian shoreline and 125 fossil mollusk shell samples from the Atlantic coast of Moroccan High Atlas are discussed.For corals, the obtained ages are in good agreement with the ages reported previously on urecristallized corals except in some sites where some samples are affected by a cementation of younger aragonite.For mollusk shells, the obtained ages are in the most of cases, rejuvenated.This rejuvenation is due eventually to a post-incorporation of secondary uranium that is responsible of the wide dispersion of apparent ages of mollusk shells.

Assessment of efficacy and safety of a fractionated bipolar radiofrequency device for the treatment of lower face wrinkles and laxity.

Science.gov (United States)

Jiang, Yueqi; Zhang, Xuting; Lu, Zhong; Gold, Michael H

2018-04-18

Skin aging, as a natural course, is a gradual process. It can be classified as either intrinsic or photo-aging. In recent years, as the attention to lower face wrinkles and laxity has raised significantly, the demands to facial rejuvenation also increased, along with a variety of technologies coming into being. Fractional bipolar RF as a novel means of rejuvenation has been used in clinical practice, but questions remain in terms of its efficacy and safety. Considering a large population in our country and huge demands for skin tightening, we did this research to evaluate the efficacy and safety of fractional bipolar radiofrequency.

Natural look in volume restoration.

Science.gov (United States)

Lupo, Mary P

2008-09-01

Filling and volumizing injection procedures are currently widely used for facial augmentation and re-establishing a youthful appearance. Aesthetic physicians have advanced from the practice of treating single lines and wrinkles towards filling large facial areas to globally restore natural facial contours and meet patient demand for nonsurgical rejuvenation. This review describes the different categories of fillers and volumizers based on their duration of action and ability to create a natural looking effect; they can be broadly classified as temporary or long-lasting biodegradable agents, or permanent nonbiodegradable agents. Temporary fillers are effective to correct lines and wrinkles, but may not adequately meet the need for global facial rejuvenation and volume replacement in a long-term, cost-efficient manner. Permanent fillers for global restoration pose the issue of long-term safety, and may not be compatible with changes in facial architecture with continued aging. Longer lasting volumizers provide patients with a durable, effective option for the restoration of facial volume and the re-establishment of youthful facial contours. Temporary fillers and volumizers may also be used in combination to provide a wide source of options for the global restoration and rejuvenation of the face.

Post-mortem re-cloning of a transgenic red fluorescent protein dog.

Science.gov (United States)

Hong, So Gun; Koo, Ok Jae; Oh, Hyun Ju; Park, Jung Eun; Kim, Minjung; Kim, Geon-A; Park, Eun Jung; Jang, Goo; Lee, Byeong-Chun

2011-12-01

Recently, the world's first transgenic dogs were produced by somatic cell nuclear transfer. However, cellular senescence is a major limiting factor for producing more advanced transgenic dogs. To overcome this obstacle, we rejuvenated transgenic cells using a re-cloning technique. Fibroblasts from post-mortem red fluorescent protein (RFP) dog were reconstructed with in vivo matured oocytes and transferred into 10 surrogate dogs. One puppy was produced and confirmed as a re-cloned dog. Although the puppy was lost during birth, we successfully established a rejuvenated fibroblast cell line from this animal. The cell line was found to stably express RFP and is ready for additional genetic modification.

Facial rejuvenation: Serial fat graft transfer

African Journals Online (AJOL)

Saad Mohamed Saad Ibrahiem

2016-02-01

Feb 1, 2016 ... This a clinical study carried out to test the aesthetic outcome of serial injection of the cryo-preserved fat cells for both aesthetic and reconstructive purposes. Methods: Clinical ..... ucts, devices, or drugs mentioned in this manuscript that might create a ... Adipose stem cells and regenerative medicine. 7th ed.

Electric vehicle energy management system

Science.gov (United States)

Alaoui, Chakib

This thesis investigates and analyzes novel strategies for the optimum energy management of electric vehicles (EVs). These are aimed to maximize the useful life of the EV batteries and make the EV more practical in order to increase its acceptability to market. The first strategy concerns the right choice of the batteries for the EV according to the user's driving habits, which may vary. Tests conducted at the University of Massachusetts Lowell battery lab show that the batteries perform differently from one manufacturer to the other. The second strategy was to investigate the fast chargeability of different batteries, which leads to reduce the time needed to recharge the EV battery pack. Tests were conducted again to prove that only few battery types could be fast charged. Test data were used to design a fast battery charger that could be installed in an EV charging station. The third strategy was the design, fabrication and application of an Electric Vehicle Diagnostic and Rejuvenation System (EVDRS). This system is based on Mosfet Controlled Thyristors (MCTs). It is capable of quickly identifying any failing battery(s) within the EV pack and rejuvenating the whole battery pack without dismantling them and unloading them. A novel algorithm to rejuvenate Electric Vehicle Sealed Lead Acid Batteries is described. This rejuvenation extends the useful life of the batteries and makes the EV more competitive. The fourth strategy was to design a thermal management system for EV, which is crucial to the safe operation, and the achievement of normal/optimal performance of, electric vehicle (EV) batteries. A novel approach for EV thermal management, based on Pettier-Effect heat pumps, was designed, fabricated and tested in EV. It shows the application of this type of technology for thermal management of EVs.

Endothelial-regenerating cells: an expanding universe.

Science.gov (United States)

Steinmetz, Martin; Nickenig, Georg; Werner, Nikos

2010-03-01

Atherosclerosis is the most common cause for cardiovascular diseases and is based on endothelial dysfunction. A growing body of evidence suggests the contribution of bone marrow-derived endothelial progenitor cells, monocytic cells, and mature endothelial cells to vessel formation and endothelial rejuvenation. To this day, various subsets of these endothelial-regenerating cells have been identified according to cellular origin, phenotype, and properties in vivo and in vitro. However, the definition and biology, especially of endothelial progenitor cells, is complex and under heavy debate. In this review, we focus on current definitions of endothelial progenitor cells, highlight the clinical relevance of endothelial-regenerating cells, and provide new insights into cell-cell interactions involved in endothelial cell rejuvenation.

Anatomic and mechanical considerations in restoring volume of the face with use of hyaluronic acid fillers with a novel layered technique.

Science.gov (United States)

Thomas, Mohan K; Dsilva, James A; Borole, Ateesh J; Naik, Sudhir M; Sarkar, Soma G

2014-01-01

Facial fillers have revolutionized the field of cosmetic facial rejuvenation as it has become the prime sought - after rejuvenation procedure offering youthful, 3-dimensional look with minimal invasiveness. Fillers are expensive and need to be redone periodically hence a sound understanding of structural basis on which they are laid is important in reducing the quantity of filler required in each sitting as well as increasing the longevity of results. The aim of the following study is to analyse a novel method of facial filling "The pillars pyramids and tie beams (PPT)" technique and its advantages over the conventional methods. A novel technique of injecting the facial fillers was employed on 67 patients visiting our clinic. These patients were followed-up for a period of 3 years. We observed that the amount of filler material required in initial sitting remains the same, however the frequency of touch up visits is decreased and so is the amount of filler material required for follow-up injections. Facial contour remodelling is being revolutionised by the new filler materials for volume augmentation and no uniform consensus has been reached on the techniques currently used in clinical practice. We advocate this novel PPT technique of facial filling in facial rejuvenation to restore a youthful look as a primary goal.

Research and development of photovoltaic power system. Study on structural defects in silicon-based amorphous materials; Taiyoko hatsuden system no kenkyu kaihatsu. Amorphous silicon kei zairyo no kozo kekkan ni kansuru kenkyu

Energy Technology Data Exchange (ETDEWEB)

Shimizu, T [Kanazawa University, Ishikawa (Japan). Faculty of Engineering

1994-12-01

Described herein are the results of the FY1994 research program for structural defects of silicon-based amorphous materials for solar cells. The study on light generation defects of the a-Si:H system and rejuvenation process by annealing establishes the effects of light irradiation time on changed neutral dangling bond density as a result of light irradiation at varying temperature of 77K, room temperature and 393K. The study on annealing to rejuvenate light generation defects of various types of a-Si-H systems establishes the activation energy distribution with respect to annealing to remove light-induced defects, showing that hydrogen affects the distribution of light-induced defects. The study on decaying process of light-induced ESR for undoped and N-doped a-Si:H systems observes the decaying process of light-induced ESR, after light is cut off, extending for a period of several seconds to several hours at 77K for the a-Si-H systems containing N in a range from 0 to 12at%. The other results presented are space distribution of neutral defects of light-irradiated a-Si-H systems, and rejuvenation process of light-induced spin for the a-Si(1-x)N(x):H composition. 6 figs.

Palestinian Elections

National Research Council Canada - National Science Library

Pina, Aaron D

2006-01-01

.... In 2002, the Palestinian Authority (PA), under increasing internal and external pressure, announced a so-called 100-Day Reform Plan for institutional reform and elections in order to rejuvenate PA leadership...

The Functions and Spiritual Connotations of Traditional Music ...

African Journals Online (AJOL)

user

2013-07-07

Jul 7, 2013 ... implication, aesthetics, rejuvenation, identity and solidarity, entertainment ... Ufie music also enhances education in the cultural norms and practices. Through it ... common aspirations, beliefs and socio-cultural value systems.

Winning the Invisible War: An Agricultural Pilot Plan for Afghanistan

National Research Council Canada - National Science Library

Borcherdt, Edward; Carson, Austin; Kennefick, Frank; Moseley, James; Taylor, William; Ullman, Harlan; Wentz, Larry

2008-01-01

.... The third was to propose specific pilot plans for rejuvenating the agricultural sector. These plans were developed by experienced American farmers and other experts with long careers in government, agriculture, and development...

Disección anatómica de la musculatura mímica facial: revisión iconográfica de apoyo a los tratamientos complementarios en rejuvenecimiento facial Anatomical dissection of the mimic facial musculature: iconographic review as a support to the complementary treatments in facial rejuvenation

Directory of Open Access Journals (Sweden)

C. Casado Sánchez

2011-03-01

Full Text Available A la hora de valorar las múltiples técnicas empleadas en el rejuvenecimiento facial y centrándonos de manera particular en aquellos procedimientos mínimamente invasivos complementarios a las intervenciones habituales en Cirugía Plástica-Estética, cobra especial relevancia el conocimiento exhaustivo de las estructuras musculares implicadas en la mímica facial. A tal efecto, se ha realizado un estudio anatómico en cadáveres frescos, en los que se han disecado las principales estructuras referidas. Se presenta un resumen iconográfico de los músculos faciales implicados, haciendo hincapié en su anatomía descriptiva y funcional, así como un recuerdo de las principales áreas problemáticas por alguna circunstancia especial (presencia de un nervio sensitivo o motor.To value the multiple technologies involved in facial rejuvenation and focusing in those minimally invasive complementary procedures to the usual Plastic and Aesthetic Surgeries, it´s very important the exhaustive knowledge of the muscular structures involved in the facial movements. To such an effect, an anatomical study has been realized in fresh corpses, dissecting the principal above-mentioned structures. We present an iconographic summary of the facial implied muscles, emphasizing in his descriptive and functional anatomy, as well as a recollection of the principal problematic areas for some special circumstance (presence of a sensory or motor nerve.

Anatomic and mechanical considerations in restoring volume of the face with use of hyaluronic acid fillers with a novel layered technique

Directory of Open Access Journals (Sweden)

Mohan K Thomas

2014-01-01

Full Text Available Context: Facial fillers have revolutionized the field of cosmetic facial rejuvenation as it has become the prime sought - after rejuvenation procedure offering youthful, 3-dimensional look with minimal invasiveness. Fillers are expensive and need to be redone periodically hence a sound understanding of structural basis on which they are laid is important in reducing the quantity of filler required in each sitting as well as increasing the longevity of results. Aim: The aim of the following study is to analyse a novel method of facial filling "The pillars pyramids and tie beams (PPT" technique and its advantages over the conventional methods. Subjects and Methods: A novel technique of injecting the facial fillers was employed on 67 patients visiting our clinic. These patients were followed-up for a period of 3 years. Results: We observed that the amount of filler material required in initial sitting remains the same, however the frequency of touch up visits is decreased and so is the amount of filler material required for follow-up injections. Conclusion: Facial contour remodelling is being revolutionised by the new filler materials for volume augmentation and no uniform consensus has been reached on the techniques currently used in clinical practice. We advocate this novel PPT technique of facial filling in facial rejuvenation to restore a youthful look as a primary goal.

Reuse of Hydrotreating Spent Catalyst

International Nuclear Information System (INIS)

Habib, A.M.; Menoufy, M.F.; Amhed, S.H.

2004-01-01

All hydro treating catalysts used in petroleum refining processes gradually lose activity through coking, poisoning by metal, sulfur or halides or lose surface area from sintering at high process temperatures. Waste hydrotreating catalyst, which have been used in re-refining of waste lube oil at Alexandria Petroleum Company (after 5 years lifetime) compared with the same fresh catalyst were used in the present work. Studies are conducted on partial extraction of the active metals of spent catalyst (Mo and Ni) using three leaching solvents,4% oxidized oxalic acid, 10% aqueous sodium hydroxide and 10% citric acid. The leaching experiments are conducting on the de coked extrude [un crushed] spent catalyst samples. These steps are carried out in order to rejuvenate the spent catalyst to be reused in other reactions. The results indicated that 4% oxidized oxalic acid leaching solution gave total metal removal 45.6 for de coked catalyst samples while NaOH gave 35% and citric acid gave 31.9 % The oxidized leaching agent was the most efficient leaching solvent to facilitate the metal removal, and the rejuvenated catalyst was characterized by the unchanged crystalline phase The rejuvenated catalyst was applied for hydrodesulfurization (HDS) of vacuum gas oil as a feedstock, under different hydrogen pressure 20-80 bar in order to compare its HDS activity

Geologic Mapping, Volcanic Stages and Magmatic Processes in Hawaiian Volcanoes

Science.gov (United States)

Sinton, J. M.

2005-12-01

The concept of volcanic stages arose from geologic mapping of Hawaiian volcanoes. Subaerial Hawaiian lava successions can be divided generally into three constructional phases: an early (shield) stage dominated by thin-bedded basaltic lava flows commonly associated with a caldera; a later (postshield) stage with much thicker bedded, generally lighter colored lava flows commonly containing clinopyroxene; calderas are absent in this later stage. Following periods of quiescence of a half million years or more, some Hawaiian volcanoes have experienced renewed (rejuvenated) volcanism. Geological and petrographic relations irrespective of chemical composition led to the identification of mappable units on Niihau, Kauai, Oahu, Molokai, Maui and Hawaii, which form the basis for this 3-fold division of volcanic activity. Chemical data have complicated the picture. There is a growing tendency to assign volcanic stage based on lava chemistry, principally alkalicity, into tholeiitic shield, alkalic postshield, and silica undersaturated rejuvenation, despite the evidence for interbedded tholeiitic and alkalic basalts in many shield formations, and the presence of mildly tholeiitic lavas in some postshield and rejuvenation formations. A consistent characteristic of lava compositions from most postshield formations is evidence for post-melting evolution at moderately high pressures (3-7 kb). Thus, the mapped shield to postshield transitions primarily reflect the disappearance of shallow magma chambers (and associated calderas) in Hawaiian volcanoes, not the earlier (~100 ka earlier in Waianae Volcano) decline in partial melting that leads to the formation of alkalic parental magmas. Petrological signatures of high-pressure evolution are high-temperature crystallization of clinopyroxene and delayed crystallization of plagioclase, commonly to <3 % MgO. Petrologic modeling using pMELTS and MELTS algorithms allows for quantification of the melting and fractionation conditions giving

Stochastic feeding of fish larvae and their metabolic handling of starvation

Science.gov (United States)

Augustine, S.; Litvak, M. K.; Kooijman, S. A. L. M.

2011-11-01

Developmental patterns of yolk-sac larvae are well captured by the standard DEB model: (i) when feeding is delayed post birth the size at which post-feeding growth begins is reduced but the rate of growth post-feeding is unaffected and (ii) maternal effects (initial energy in egg) show up as differences in condition at birth and maximum length of non fed individuals. We extended the standard DEB model in two ways to account for starvation. (I): if somatic maintenance can no longer be paid structure is also mobilized to cover the costs, but at an extra cost-conversion efficiency of structure to energy. Death occurs if structure reaches a fraction of the maximum at the onset of shrinking. (II): if maturity maintenance can no longer be paid then maturity level decays exponentially (rejuvenation). Hazard due to rejuvenation is proportional to the difference between maturity and the maximum maturity at the onset of rejuvenation. We performed Monte Carlo simulation studies which treat feeding as a random process to evaluate the contribution of the metabolic handling of starvation to early teleost life history. The simulations suggest that food density strongly impacts growth, energy reserves, mineral fluxes, hazard and mortality from shrinking. Environmental factors can soon override maternal induced differences between individuals. Moreover in the low food density, simulated individuals from eggs of lower caloric content experience mortality from shrinking earlier than their counterparts issued from higher energy eggs. Empirically observed patterns of real data, i.e. high scatter in respiration in combination with low scatter in lengths, can be expected when the metabolism is treated as a deterministic system while behaviourally controlled input is stochastic. At low food densities where mortality from shrinking reaches 10% almost all individuals experience hazard due to rejuvenation. This hazard is difficult to access experimentally but represents moments of heightened

Automated High-Performance Liquid Chromatography Saturate, Aromatic, Resin, and Asphaltene Separation

Science.gov (United States)

2016-10-01

Dividing a material into its constituent parts is necessary to define its composition. These compositional analyses are useful in binder formulation through blending, rejuvenation, and modification, as well as prediction of physical performance. Norm...

Pruning Shrubs

OpenAIRE

French, Sue (Sue C.); Appleton, Bonnie Lee, 1948-2012

2009-01-01

Understanding the "natural habit" or "shape" of shrubs will help you determine how to prune them. This publication explores how and when to prune, maintenance and rejuvenation pruning, and the growth habit of shrubs.

Platelet-Rich Plasma Increases Pigmentation.

Science.gov (United States)

Uysal, Cagri A; Ertas, Nilgun Markal

2017-11-01

Platelet-rich plasma (PRP) is an autologous solution of plasma containing 4 to 7 times the baseline concentration of human platelets. Platelet-rich plasma has been widely popular in facial rejuvenation to attenuate wrinkles and has been practically used. The authors have been encountering various patients of increased hiperpigmentation following PRP applications that were performed to attenuate the postinflammatory hiperpigmentation especially after laser treatment. The authors have been using PRP for facial rejuvenation in selected patients and in 1 patient the authors have encountered increased pigmentation over the pigmented skin lesions that were present before the application. The authors recommend that the PRP might increase pigmentation especially in the face region and precautions might be taken before and after the application. Platelet-rich plasma should not be used for the treatment of post inflammatory hiperpigmentation.

AN EVALUATION OF THE SPATIAL DIMENSION OF LANDSCAPE ...

African Journals Online (AJOL)

Osondu

2012-03-30

Mar 30, 2012 ... with adequate landscaping, - using landscape elements, to create a ... air, water and energy cycles that replenish and rejuvenate ... First, using the street map of. Ogbomoso ... swimming pools, etc, were regarded as conscious.

Periorbital Rejuvenation Surgery in the Geriatric Population

Directory of Open Access Journals (Sweden)

Ann Yi-Chiun Chuang

2010-09-01

Full Text Available Periorbital aging is an unavoidable, progressive process that is often accompanied by visual obscurations and ocular discomfort. With surgical correction, patients may benefit not only functionally but also psychosocially when an aesthetic outcome is obtained. The periorbital anatomical structures in elderly patients are complex and interlocking, requiring a thorough evaluation and systematic approach. Most elderly patients are reluctant to undergo procedures that require prolonged surgical and recovery times if they think it is only for cosmetic improvement. We review contemporary periorbital surgical methods suitable for a geriatric population, namely procedures that are low-cost, low-risk, with short operative and recovery times, and that have excellent patient acceptability. It is feasible to select procedures that can be customized to the needs of the elderly.

Rejuvenating Allen's Arc with the Geometric Mean.

Science.gov (United States)

Phillips, William A.

1994-01-01

Contends that, despite ongoing criticism, Allen's arc elasticity formula remains entrenched in the microeconomics principles curriculum. Reviews the evolution and continuing scrutiny of the formula. Argues that the use of the geometric mean offers pedagogical advantages over the traditional arithmetic mean approach. (CFR)

Reinforced orbitotemporal lift: contribution to midface rejuvenation.

Science.gov (United States)

Renó, Waldir Teixeira

2003-02-01

The changes in the aging face occur from progressive ptosis of the skin, fat, and muscle, in conjunction with bone absorption and cartilage atrophy. In the orbital region, hollowness and compartmentalization occur. Conventional face lift procedures correct only the skin flaccidity, and superficial musculoaponeurotic system techniques reposition the skin and platysma without repositioning the middle third of the face, creating an artificial jawline. Subperiosteal rhytidectomy disrupts the anatomy of the periorbita, which gives the patient a certain scarecrow aspect. Composite rhytidectomy associated with brow lift and blepharoplasty may offer better results, with improvement in the malar and orbital regions. The reinforced orbitotemporal lift (ROTEL) is a new procedure in a face lift that allows the orbicularis oculi muscle and all the structures connected to it to be elevated and stretched and the orbitotemporal skin to be raised, repositioning these structures and ending orbital compartmentalization. The result is an impressive improvement in the malar-orbitotemporal region, resulting in a natural and youthful appearance.

Volume rejuvenation of the facial upper third.

Science.gov (United States)

Buckingham, Edward D; Glasgold, Robert; Kontis, Theda; Smith, Stephen P; Dolev, Yalon; Fitzgerald, Rebecca; Lam, Samuel M; Williams, Edwin F; Pollei, Taylor R

2015-02-01

The next three articles in this issue take a unique approach to discussing volumetric restoration. Robert Glasgold has provided an assessment for each facial region and five different renowned authors (TK, SPS, RF, SML, and EFW) have been asked to speak on a particular volumetric product, of which they are considered an expert, as it applies to the different regions of the face. The articles are broken into the following: (1) upper third which corresponds to the upper eyelid, brow, temple, and forehead; (2) middle third which will cover lower eyelid, cheek, and perioral area; and (3) lower third which discusses the marionette, prejowl, and jawline. Our hope is that by placing differing opinions of experienced authors, organized by facial region together, the reader will have the opportunity to more readily compare the options. The contributing authors and their product area are as follows: Theda Kontis, MD-hyaluronic acid; Steve Smith, MD-calcium hydroxyl appetite; Rebecca Fitzgerald, MD-poly-L lactic acid; Sam Lam, MD-polymethyl methacrylate; and Edwin Williams, MD-Autologous Fat Transfer. If the author included general comments on the product, they are included in the article on the upper face only and are not repeated. Please note that other individuals may also have significantly assisted in the production of these articles, but those listed above are the senior authors. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Use of barbed threads in facial rejuvenation.

Science.gov (United States)

Kalra, Rakesh

2008-10-01

Use of barbed threads, available with uni- and bi-directional cogs or barbs, is a semi-invasive method of lifting sagging skin of the face. Areas treated with this method include the eyebrows, the cheeks, the jowls and the neck. Ease of use and a shorter down-time have made their use popular. Specific indications, operative procedures, risks and complications are described and some clinical results of the author shown.

Is it time to rejuvenate the forceps?

LENUS (Irish Health Repository)

Talukdar, Sanchila

2013-08-01

The obstetric forceps was designed to assist extraction of the foetal head and thereby accomplish delivery of the foetus in the second stage of labour. More than 700 types of obstetric forceps have been described. An understanding of the anatomy of the birth canal and the foetal head is a prerequisite to becoming a skilled and safe user of forceps. Operative vaginal delivery rates have remained stable at between 10 and 13 %. The last few decades has seen a rise in caesarean section, along with the introduction and safe use of the vacuum extractor. This has resulted in a decline both in the use of the obstetric forceps as well as in the training for the same. The forceps is less likely to fail when used as the primary instrument thereby reducing the need for the sequential use of two instruments which increase the morbidity of the neonate. Perineal trauma is more likely to occur with the use of the forceps but the evidence is that the maternal concern is less when compared to the ventouse. Simulation training is an important part of obstetric training. Application of forceps blades in the simulation setting can improve the skill level of obstetricians. The use of the forceps should not be decreasing and more senior involvement in training is necessary so that juniors develop the proper skills to perform forceps delivery in a competent and safe manner. It is vital that the art of the forceps is not lost to future generations of obstetricians and the women they care for.

[Botulinum toxin and rejuvenation of the eye].

Science.gov (United States)

Volpei, Ch; Miniconi, M-J; Brunner, C I; Besins, T; Braccini, F

2013-01-01

Treatments with botulinum toxin in the forehead and periorbital areas may induce disappointing or even paradoxical results. Our study, focused on this area aimed at refining injection techniques by analyzing muscular balances and comparing the effect according to injection doses and topography. This experimental study has been carried out in the form of 2 session workshops, with volunteers duly informed of the study contents and giving their informed consent. It was conducted by physicians and surgeons members of SAMCEP* (Société Avancée de Médecine et Chirurgie Esthétique et Plastique). The botulinum toxin was onabotulinumtoxin A. Results were evaluated 15 days after treatment, in regard to global eyebrow position, eyebrow head and tail position; muscle interactions; lines above the eyebrow. Eleven case reports and their results are shown and discussed. Our study underlines two important insights: muscle balances and "border areas", between orbicularis oculi and corrugator, key features for eyebrow head, and between frontalis and orbicularis oculifor eyebrow tail.

Use of barbed threads in facial rejuvenation

Directory of Open Access Journals (Sweden)

Kalra Rakesh

2008-10-01

Full Text Available Use of barbed threads, available with uni- and bi-directional cogs or barbs, is a semi-invasive method of lifting sagging skin of the face. Areas treated with this method include the eyebrows, the cheeks, the jowls and the neck. Ease of use and a shorter down-time have made their use popular. Specific indications, operative procedures, risks and complications are described and some clinical results of the author shown.

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Indian Academy of Sciences (India)

2016-11-30

Nov 30, 2016 ... tion of the autosomes and sex-chromosomes of maternal origin from those of ...... of being able to rejuvenate cells without de-differentiation are self-evident. ...... Singh PB 1994 Molecular mechanisms of cellular determination:.

The Addition of Platelet-Rich Plasma to Facial Lipofilling: A Double-Blind, Placebo-Controlled, Randomized Trial.

Science.gov (United States)

Willemsen, Joep C N; Van Dongen, Joris; Spiekman, Maroesjka; Vermeulen, Karin M; Harmsen, Martin C; van der Lei, Berend; Stevens, H P Jeroen

2018-02-01

Lipofilling is a treatment modality to restore tissue volume, but it may also rejuvenate the aging skin. Platelet-rich plasma has been reported to augment the efficacy of lipofilling, both on graft take and rejuvenation, by altering the adipose-derived stem cells. The authors hypothesized that addition of platelet-rich plasma would increase the rejuvenating effect and shorten recovery time. The study conducted was a single-center, double-blind, placebo-controlled, randomized trial (2012 to 2015). In total, a well-defined cohort of 32 healthy female patients enrolled in the study, with 25 completing the follow-up. All patients underwent aesthetic facial lipofilling with either saline or platelet-rich plasma added. Outcome was determined by changes in skin elasticity, volumetric changes of the nasolabial fold, recovery time, and patient satisfaction during follow-up (1 year). Platelet-rich plasma did not improve the outcome of facial lipofilling when looking at skin elasticity improvement, graft volume maintenance in the nasolabial fold. Reversal of the correlation between age and elasticity, however, might suggest a small effect size, and thus might not be significant with our small study population. This randomized, double-blind, placebo-controlled study clearly has shown that platelet-rich plasma significantly reduces postoperative recovery time but does not improve patient outcome when looking at skin elasticity, improvement of the nasolabial fold, or patient satisfaction. The reversal of the correlation between age and elasticity might indicate some effect on skin but requires more power in future studies. Therapeutic, II.

Ultrasonic measurements for in-service assessment of wrought Inconel 625 cracker tubes of heavy water plants

International Nuclear Information System (INIS)

Kumar, Anish; Rajkumar, K.V.; Jayakumar, T.; Raj, Baldev; Mishra, B.

2006-01-01

The degradation in mechanical properties of Inconel 625 ammonia cracker tubes occurs during the service for long duration in heavy water plants. The present study brings out the possibility of using Poisson's ratio (derived from measurement of time of flight of ultrasonic waves) in combination with hardness measurements, as an effective non-destructive tool for assessment of in-service degradation of Inconel 625 cracker tubes and qualification of re-solution annealing heat treatment for their rejuvenation. Further, the study also indicates the feasibility of extending the life of some of the tubes beyond the presently followed 120 000 h, before they are taken up for re-solution annealing, without affecting their serviceability. However, further studies are required to identify quantitative criterion for Poisson's ratio and hardness values, for deciding on the basis for removal of the tubes for rejuvenation

Validated modified Lycopodium spore method development for ...

African Journals Online (AJOL)

Validated modified lycopodium spore method has been developed for simple and rapid quantification of herbal powdered drugs. Lycopodium spore method was performed on ingredients of Shatavaryadi churna, an ayurvedic formulation used as immunomodulator, galactagogue, aphrodisiac and rejuvenator. Estimation of ...

Missing a trick in geothermal exploration

Science.gov (United States)

Younger, Paul L.

2014-07-01

Expansion of geothermal energy use across the globe is restricted by out-of-date prejudices. It is time for geothermal exploration to be extended to a broader range of environments and rejuvenated with the latest insights from relevant geoscience disciplines.

Lack of metabolic ageing in the long-lived flatworm Schmidtea polychroa

NARCIS (Netherlands)

Mouton, Stijn; Willems, Maxime; Houthoofd, Wouter; Bert, Wim; Braeckman, Bart P.

Freshwater planarians have a large totipotent stem cell population allowing high rates of cell renewal and morphological plasticity. It is often suggested that they are able to rejuvenate during fission, regeneration and starvation. These features, together with the rapidly expanding molecular

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African Journals Online (AJOL)

Fifty-one per cent of the population live below the poverty line. Less .... This impedes South Sudan's efforts to rejuvenate its economy nine years after the CPA which ...... of the MFI in this fashion interfers with the group's autonomy, and detracts.

Emerging investigator series: the rise of nano-enabled photothermal materials for water evaporation and clean water production by sunlight

KAUST Repository

Wang, Peng

2018-01-01

Solar driven water evaporation and distillation is an ancient technology, but has been rejuvenated by nano-enabled photothermal materials in the past 4 years. The nano-enabled state-of-the-art photothermal materials are able to harvest a full solar

Histopathologic changes of the eyelid skin following trichloroacetic acid chemical peel

NARCIS (Netherlands)

Dailey, R. A.; Gray, J. F.; Rubin, M. G.; Hildebrand, P. L.; Swanson, N. A.; Wobig, J. L.; Wilson, D. J.; Speelman, P.

1998-01-01

The use of trichloroacetic acid (TCA) as a periorbital and eyelid peel for skin rejuvenation is gaining significant acceptance among oculoplastic surgeons, dermatologists, and other surgery groups. In spite of the current enthusiasm, there remain potentially serious complications resulting from any

In vitro seed germination and rootstock establishing for micrografting of Theobroma cacao L

Science.gov (United States)

Micrografting has been successfully implemented in several plant species of Acacia, Citrus, Eucalyptus, Havea, Malus, Olea, Opuntia, Prunus and other genera. This technique is employed for plant rejuvenation, true-to-type propagation, genetic improvement, recovery of virus-free plants, testing of po...

Success factors in new ventures : A meta-analysis

NARCIS (Netherlands)

Song, Michael; Podoynitsyna, Ksenia; van der Bijl, H.M.; Halman, Johannes I.M.

2008-01-01

Technology entrepreneurship is key to economic development. New technology ventures (NTVs) can have positive effects on employment and could rejuvenate industries with disruptive technologies. However, NTVs have a limited survival rate. In our most recent empirical study of 11,259 NTVs established

Success factors in new ventures : a meta-analysis

NARCIS (Netherlands)

Song, Michael; Podoynitsyna, K.S.; Bij, van der J.D.; Halman, J.I.M.

2008-01-01

Technology entrepreneurship is key to economic development. New technology ventures (NTVs) can have positive effects on employment and could rejuvenate industries with disruptive technologies. However, NTVs have a limited survival rate. In our most recent empirical study of 11,259 NTVs established

Clinical, biophysical, immunohistochemical, and in vivo reflectance confocal microscopy evaluation of the response of subjects with sensitive skin to home-use fractional non-ablative photothermolysis device

NARCIS (Netherlands)

Richters, R.J.; Hoogedoorn, L.; Uzunbajakava, N.E.; Janssen, L.D.; Tom Nuijs, A.M.; Erp, P.E.J. van; Kerkhof, P.C.M. van de

2016-01-01

BACKGROUND: Fractional photothermolysis using professional devices is a well-accepted and a widely used technique for skin rejuvenation. Recently, the technology has also been implemented in devices for home-use. Yet, a subpopulation of consumers exists that reacts excessively to this stimulation

Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses.

NARCIS (Netherlands)

Seyfizadeh, N; Muthuswamy, Ravikumar; Mitchell, Duane; Nierkens, S; Seyfizadeh, Nayer

2016-01-01

Better prognoses associated with increased T cell infiltration of tumors, as seen with chimeric antigen receptor (CAR) T cell therapies and immune checkpoint inhibitors, portray the importance and potential of the immune system in controlling tumors. This has rejuvenated the field of cancer

Food supplement 20070721-GX may increase CD34+ stem cells and telomerase activity.

Science.gov (United States)

Lin, Po-Cheng; Chiou, Tzyy-Wen; Liu, Po-Yen; Chen, Shee-Ping; Wang, Hsin-I; Huang, Pi-Chun; Lin, Shinn-Zong; Harn, Horng-Jyh

2012-01-01

Few rejuvenation and antiaging markers are used to evaluate food supplements. We measured three markers in peripheral blood to evaluate the antiaging effects of a food supplement containing placental extract. Samples were evaluated for CD34(+) cells, insulin-like growth factor 1 (IGF1), and telomerase activity, which are all markers related to aging. To control the quality of this food supplement, five active components were monitored. In total, we examined 44 individuals who took the food supplement from 1.2 months to 23 months; the average number of CD34(+) cells was almost 6-fold higher in the experimental group compared with the control group. Food supplement intake did not change serum IGF1 levels significantly. Finally, the average telomerase activity was 30% higher in the subjects taking this food supplement. In summary, our results suggest that the placental extract in the food supplement might contribute to rejuvenation and antiaging.

Young endothelial cells revive aging blood.

Science.gov (United States)

Chang, Vivian Y; Termini, Christina M; Chute, John P

2017-11-01

The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications. In this issue of the JCI, Poulos and colleagues demonstrate that infusions of bone marrow (BM) endothelial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice. Additionally, delivery of young BM ECs along with HSCs following total body irradiation improved HSC engraftment and enhanced survival. These results suggest an important role for BM endothelial cells (ECs) in regulating hematopoietic aging and support further research to identify the rejuvenating factors elaborated by BM ECs that restore HSC function and the immune repertoire in aged mice.

Carcinogenesis related to intense pulsed light and UV exposure

DEFF Research Database (Denmark)

Hedelund, L; Lerche, C; Wulf, H C

2006-01-01

This study examines whether intense pulsed light (IPL) treatment has a carcinogenic potential itself or may influence ultraviolet (UV)-induced carcinogenesis. Secondly, it evaluates whether UV exposure may influence IPL-induced side effects. Hairless, lightly pigmented mice (n=144) received three...... observation period. Side effects were evaluated clinically. No tumors appeared in untreated control mice or in just IPL-treated mice. Skin tumors developed in UV-exposed mice independently of IPL treatments. The time it took for 50% of the mice to first develop skin tumor ranged from 47 to 49 weeks...... in preoperative UV-exposed mice (p=0.94) and from 22 to 23 weeks in pre- and postoperative UV-exposed mice (p=0.11). IPL rejuvenation of lightly pigmented skin did not induce pigmentary changes (p=1.00). IPL rejuvenation of UV-pigmented skin resulted in an immediate increased skin pigmentation and a subsequent...

Stem cell facelift: between reality and fiction.

Science.gov (United States)

Atiyeh, Bishara S; Ibrahim, Amir E; Saad, Dibo A

2013-03-01

Stem cells are "big business" throughout medical technology, and their potential application in cosmetic procedures is no exception. One of the latest nonsurgical facial treatments (and new catchphrases) in plastic surgery is the "stem cell facelift." It is evident from the currently available scientific literature that the use of stem cell therapy for facial rejuvenation is limited to the theoretical induction of skin tightening and can in no way be equated to a facelift. In fact, what is advertised and promoted as a new and original technique of stem cell facelifting is mostly stem cell-enriched lipofilling. Despite encouraging data suggesting that adult stem cells hold promise for future applications, the data from clinical evidence available today do not substantiate the marketing and promotional claims being made to patients. To claim that the "stem cell facelift" is a complete facial rejuvenation procedure surgery is unethical.

Origin of depleted components in basalt related to the Hawaiian hot spot: Evidence from isotopic and incompatible element ratios

Science.gov (United States)

Frey, F. A.; Huang, S.; Blichert-Toft, J.; Regelous, M.; Boyet, M.

2005-02-01

The radiogenic isotopic ratios of Sr, Nd, Hf, and Pb in basaltic lavas associated with major hot spots, such as Hawaii, document the geochemical heterogeneity of their mantle source. What processes created such heterogeneity? For Hawaiian lavas there has been extensive discussion of geochemically enriched source components, but relatively little attention has been given to the origin of depleted source components, that is, components with the lowest 87Sr/86Sr and highest 143Nd/144Nd and 176Hf/177Hf. The surprisingly important role of a depleted component in the source of the incompatible element-enriched, rejuvenated-stage Hawaiian lavas is well known. A depleted component also contributed significantly to the ˜76-81 Ma lavas erupted at Detroit Seamount in the Emperor Seamount Chain. In both cases, major involvement of MORB-related depleted asthenosphere or lithosphere has been proposed. Detroit Seamount and rejuvenated-stage lavas, however, have important isotopic differences from most Pacific MORB. Specifically, they define trends to relatively unradiogenic Pb isotope ratios, and most Emperor Seamount lavas define a steep trend of 176Hf/177Hf versus 143Nd/144Nd. In addition, lavas from Detroit Seamount and recent rejuvenated-stage lavas have relatively high Ba/Th, a characteristic of lavas associated with the Hawaiian hot spot. It is possible that a depleted component, intrinsic to the hot spot, has contributed to these young and old lavas related to the Hawaiian hot spot. The persistence of such a component over 80 Myr is consistent with a long-lived source, i.e., a plume.

Improved Ion Resistance for III-V Photocathodes in High Current Guns

Energy Technology Data Exchange (ETDEWEB)

Mulhollan, Gregory, A.

2012-11-16

The two photocathode test systems were modified, baked and recommissioned. The first system was dedicated to ion studies and the second to electron stimulated recovery (ESR) work. The demonstration system for the electron beam rejuvenation was set up, tested and demonstrated to one of the SSRL team (Dr. Kirby) during a site visit. The requisite subsystems were transferred to SSRL, installed and photoemission studies conducted on activated surfaces following electron beam exposure. Little surface chemistry change was detected in the photoemission spectra following the ESR process. The yield mapping system for the ion (and later, the electron beam rejuvenation) studies was implemented and use made routine. Ion species and flux measurements were performed for H, He, Ne, Ar, Kr and Xe ions at energies of 0.5, 1.0 and 2.0 kV. Gas induced photoyield measurements followed each ion exposure measurement. These data permit the extraction of photoyield induced change per ion (by species) at the measured energies. Electron beam induced rejuvenation was first demonstrated in the second chamber with primary electron beam energy and dependency investigations following. A Hiden quadrupole mass spectrometer for the electron stimulated desorption (ESD) measurements was procured. The UHV test systems needed for subsequent measurements were configured, baked, commissioned and utilized for their intended purposes. Measurements characterizing the desorption products from the ESD process and secondary electron (SE) yield at the surfaces of negative electron affinity GaAs photocathodes have been performed. One US Utility Patent was granted covering the ESR process.

Evaluating Platelet-Rich Therapy for Facial Aesthetics and Alopecia: A Critical Review of the Literature.

Science.gov (United States)

Motosk O, Catherine C; Khouri, Kimberly S; Poudrier, Grace; Sinno, Sammy; Hazen, Alexes

2018-05-01

Despite the growing popularity of platelet-rich plasma, existing evidence supporting its efficacy remains controversial due to the lack of large-scale studies and standardized protocols for preparation and application. This article reviews its use in facial rejuvenation, fat grafting, acne scarring, and androgenic alopecia. Emphasis is placed on comparing methods of platelet-rich plasma preparation and application across studies. A systematic review was performed for articles published between 2006 and 2015. All clinical studies and case reports that addressed platelet-rich plasma alone and/or in combination with fat grafting for facial rejuvenation, acne scarring, or androgenic alopecia were included. Of the 22 articles included in the analysis, seven studies used platelet-rich plasma alone for facial rejuvenation, seven in combination with fat grafting, two for treatment of acne scarring, and six for treatment of androgenic alopecia. Individual study procedures, means of evaluation, and significant results are summarized. Although the majority of studies in this review report positive results, significant variation exists in preparation protocols and in the number and frequency of clinical treatments. The majority of studies report positive results for all indications evaluated in this review, but the procedure is limited by the lack of a standardized method for preparation and application of platelet-rich plasma. The extent to which significant variability in platelet-rich plasma preparation and/or application methods may affect clinical outcomes is not completely clear. In the interim, we present a consolidation of platelet-rich plasma treatment techniques and outcomes currently in use to help guide physicians in their clinical practice.

Zingiber officinale : evaulation of its Nootropic effect in mice | Joshi ...

African Journals Online (AJOL)

Ayurveda emphasizes use of herbs, nutraceuticals or life-style changes for controlling age related neurodegenerative disorders. The present study was undertaken to assess the potential of an ayurvedic rasayana (rejuvenator) drug Zingiber officinale Roscoe as a memory enhancer. Elevated plus maze and passive ...

Modeling and simulation of heat distribution in human skin caused by laser irradiation

NARCIS (Netherlands)

Luan, Y.; Dams, S.D.

2009-01-01

Study of light-based skin rejuvenation needs prospective insights of mechanism of laser tissue interaction. A well-built model plays a key role in predicting temperature distribution in human skin exposed to laser irradiation. Therefore, it not only provides guidance for in vitro experiment, but

Messianic Pedagogy

Science.gov (United States)

Lewis, Tyson

2010-01-01

Famously, Walter Benjamin once wrote that behind historical materialism lies a disavowed theological "hunchback." More importantly, it is only through a rejuvenated relation with this theological hunchback that historical materialism can ultimately realize its own revolutionary possibilities. While the theological dimension of critical theory has…

Macroeconomics after Two Decades of Rational Expectations.

Science.gov (United States)

McCallum, Bennett T.

1994-01-01

Discusses real business cycle analysis, growth theory, and other economic concepts in the context of the rational expectations revolution in macroeconomics. Focuses on post-1982 research. Concludes that the rejuvenation of growth analysis is an encouraging development because it could lead to changes in welfare policy. (CFR)

Growth response of Pterocarpus soyauxii and Lophira alata ...

African Journals Online (AJOL)

Growth response of Pterocarpus soyauxii and Lophira alata seedlings to host soil mycorrhizal inocula in relation to land use types. ... and that could be critical for successful rejuvenation of tropical trees. Key words. Arbuscular mycorrhiza-host soil inoculum-Iand use types-Pterocarpus soyauxii-Lophira alata-Cameroon ...

Triple-layer midface lifting : long-term follow-up of an effective approach to aesthetic surgery of the lower eyelid and the midface

NARCIS (Netherlands)

Stevens, Hieronymus P. Jerome D.; Willemsen, Joep C. N.; Durani, Piyush; Rasteiro, David; Omoruyi, Ogbe J.

BACKGROUND: It is becoming more and more accepted that better aesthetic results can be obtained when the lower eyelid is considered as part of the midface when contemplating surgical rejuvenation. Descent of the orbicularis muscle and midface tissue causes malar bags, loss of volume over the

Narrating Self and China

DEFF Research Database (Denmark)

Kristensen, Irina

about China and its people. Thus this study explores the questions of how these women writers adopted the roles of cultural interpreters, which allowed them to position themselves as authoritative and representative voices and, at the same time, rejuvenate China’s image in the global arena...

New governance principles for sustainable urban transport

OpenAIRE

Camagni, R.; Capello, R.; Nijkamp, P.

1996-01-01

The paper positions the communications and transport in the centre of a rejuvenation policy for a sustainable urban habitat, taking for granted the success of urban govemance will depend on the professionality of local/regional policy-making govemed by sound principles from business practice in corporate organizations.

Lashkar-e-Taiba: A Global Threat Today, a Threat to Pakistan Tomorrow

Science.gov (United States)

2012-03-20

Ahl-i-Hadith followers are essentially the South Asia version of the Salafist movement originating out of Egypt or the Wahhabis of Saudi Arabia.29...training apparatus produces what might be likened to a pyramid scheme with the system constantly rejuvenating itself.68 Multiple foiled attacks against

Options and processes for spent catalyst handling and utilization.

Science.gov (United States)

Marafi, M; Stanislaus, A

2003-07-18

The quantity of spent hydroprocessing catalysts discarded as solid wastes in the petroleum refining industries has increased remarkably in recent years due to a rapid growth in the hydroprocessing capacity to meet the rising demand for low-sulfur fuels. Due to their toxic nature, spent hydroprocessing catalysts have been branded as hazardous wastes, and the refiners are experiencing pressure from environmental authorities to handle them safely. Several alternative methods such as reclamation of metals, rejuvenation and reuse, disposal in landfills and preparation of useful materials using spent catalysts as raw materials are available to deal with the spent catalyst problem. The technical feasibility as well as the environmental and economic aspects of these options are reviewed. In addition, details of two bench-scale processes, one for rejuvenation of spent hydroprocessing catalysts, and the other for producing non-leachable synthetic aggregate materials that were developed in this laboratory, are presented in this paper.

Skin resurfacing procedures: new and emerging options

Directory of Open Access Journals (Sweden)

Loesch MM

2014-08-01

Full Text Available Mathew M Loesch,1 Ally-Khan Somani,1 Melanie M Kingsley,1 Jeffrey B Travers,1–3 Dan F Spandau1,41Department of Dermatology, 2Department of Pharmacology and Toxicology, 3Department of Pediatrics, 4Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USAAbstract: The demand for skin resurfacing and rejuvenating procedures has progressively increased in the last decade and has sparked several advances within the skin resurfacing field that promote faster healing while minimizing downtime and side effects for patients. Several technological and procedural skin resurfacing developments are being integrated into clinical practices today allowing clinicians to treat a broader range of patients' skin types and pathologies than in years past, with noteworthy outcomes. This article will discuss some emerging and developing resurfacing therapies and treatments that are present today and soon to be available.Keywords: rejuvenation, wounding, non-melanoma skin cancer, therapy

[Stimulation of proliferation by carnosine: cellular and transcriptome approaches].

Science.gov (United States)

Vishniakova, Kh S; Babizhaev, M A; Aliper, A M; Buzdin, A A; Kudriavtseva, A V; Egorov, E E

2014-01-01

Concentration of endogenous dipeptide carnosine in human muscle tissue reaches tens of millimoles. For more than 100 years of research, a lot of data concerning carnosine functions were accumulated, among which anti-aging effects are regarded most important. Heire, effect of carnosine in cell cultures was studied. It has been found that apart from the known action--an increase of the Hayflick limit and morphological rejuvenation--carnosine stimulates cell division in colony-forming assays and in the course of transition of cells to the quiescent state. The analysis of the transcriptome showed that carnosine-induced changes are mainly related to positive regulation of the cell cycle at all levels, from the onset of the DNA synthesis to chromosome condensation. One can suppose that the revealed stimulation of the cell cycle account for the carnosine-induced rejuvenation processes and a high concentration ofcarnosine in muscle tissue is required for the muscle recovery (regeneration) after excess loads.

Food Supplement 20070721-GX May Increase CD34+ Stem Cells and Telomerase Activity

Directory of Open Access Journals (Sweden)

Po-Cheng Lin

2012-01-01

Full Text Available Few rejuvenation and antiaging markers are used to evaluate food supplements. We measured three markers in peripheral blood to evaluate the antiaging effects of a food supplement containing placental extract. Samples were evaluated for CD34+ cells, insulin-like growth factor 1 (IGF1, and telomerase activity, which are all markers related to aging. To control the quality of this food supplement, five active components were monitored. In total, we examined 44 individuals who took the food supplement from 1.2 months to 23 months; the average number of CD34+ cells was almost 6-fold higher in the experimental group compared with the control group. Food supplement intake did not change serum IGF1 levels significantly. Finally, the average telomerase activity was 30% higher in the subjects taking this food supplement. In summary, our results suggest that the placental extract in the food supplement might contribute to rejuvenation and antiaging.

Punctuated 88% Phenol Peeling for the Treatment of Facial Photoaging: A Clinical and Histopathological Study.

Science.gov (United States)

de Mendonça, Maria Cristina C; Segheto, Natália N; Aarestrup, Fernando M; Aarestrup, Beatriz J V

2018-02-01

Phenol peeling is considered an important agent in the treatment of facial rejuvenation; however, its use has limitations due to its high potential for side effects. This article proposes a new peeling application technique for the treatment of photoaging, aiming to evaluate, clinically and histopathologically, the efficacy of a new way of applying 88% phenol, using a punctuated pattern. The procedure was performed in an outpatient setting, with female patients, on static wrinkles and high flaccidity areas of the face. Accompanying photographs and skin samples were taken for histopathological analysis before and after treatment. It was shown that 88% phenol applied topically using a punctuated technique is effective in skin rejuvenation. The authors thus suggest, based on this new proposal, that further studies be conducted with a larger group of patients to better elucidate the action mechanisms of 88% phenol. This new form of application considerably reduced patients' withdrawal from their regular activities, besides reducing the cost, compared with the conventional procedure.

Rejuvenecimiento periorbitario no invasivo Non-invasive periorbital rejuvenation

Directory of Open Access Journals (Sweden)

J. L. Muñóz del Olmo

2008-03-01

Full Text Available Cirujanos plásticos y médicos estéticos se esfuerzan por lograr resultados satisfactorios y estéticos que mejoren o suavicen el paso del tiempo a nivel facial, con un especial interés o énfasis en el área periorbitaria. Un gran número de pacientes consultan para mejorar esta zona, pero por diferentes motivos desean que los procedimientos que se les realicen sean poco invasivos y con resultados rápidos, permitiéndoles así incorporarse lo antes posible a sus actividades cotidianas. Es fundamental el conocimiento de las proporciones faciales y periorbitarias para lograr resultados naturales. El objetivo de la técnica que proponemos es lograr una bioestimulación local de la piel, restaurar los volúmenes y reducir las arrugas de expresión o dinámicas, consiguiendo así una apariencia relajada y juvenil en el paciente.Plastic surgeons and aesthetic doctors are making an effort to reach positive aesthetic results. Their aim is to soften the effects of age on facial features stressing in the periorbital area. Many patients come to improve their facial image on this area, but they are asking for non-invasive and fast procedures to keep on their daily life. It is indispensable the knowledge of facial and periorbital proportions to achieve a more natural effect. The aim of the technique exposed is to achieve a local bioestimulation on skin, to restore volumes and to reduce expression and dynamical wrinkles. The expected result is a relaxing, youthful appearance.

Sweet Rejuvenation: Linking In-Service and Teacher Induction.

Science.gov (United States)

McNair, Veda; And Others

This paper describes a collaborative effort between a local education agency (LEA) and an institution of higher education to link inservice education with induction--teachers teaching teachers. The program, based on the Joyce coaching paradigm and recent cognitive development research, posits that long-term training conducted by trained teachers…

A 25th Anniversary Rejuvenation for the SPS

CERN Multimedia

2001-01-01

The SPS has just turned 25, and to mark the occasion it has been treated to a facelift like none before. After serving as injector for LEP, the SPS is being prepared to pre-accelerate proton beams for the LHC.

Exploring cucumber extract for skin rejuvenation | Akhtar | African ...

African Journals Online (AJOL)

This study was designed to develop a topical skin-care cream water in oil (w/o) ... versus its vehicle (Base) as control and evaluates its effects on skin-melanin, skin erythema, skin moisture, skin sebum and transepidermal water loss (TEWL).

Rejuvenating the sun and avoiding other global catastrophes

CERN Document Server

Beech, Martin

2008-01-01

Canadian academic Martin Beech has written a text that crosses the line between science fiction and science fact. Put simply, his book details a method that just might be able to stop the Sun from losing its power and, ultimately, save humanity and the Earth itself.

Ziziphus mauritiana leaf extract emulsion for skin rejuvenation

African Journals Online (AJOL)

Tropical Journal of Pharmaceutical Research May 2016; 15 (5): 929-936 ... this period, stability parameters, including liquefaction, phase separation, color, electrical ... Both active and placebo formulations changed skin elasticity and erythema ...

Spotlight on middle childhood: Rejuvenating the 'forgotten years'.

Science.gov (United States)

Mah, V Kandice; Ford-Jones, E Lee

2012-02-01

Middle childhood, from six to 12 years of age, is often known as the 'forgotten years' of development because most research is focused on early childhood development or adolescent growth. However, middle childhood is rich in potential for cognitive, social, emotional and physical advancements. During this period, the brain is actively undergoing synaptic pruning and, as such, is constantly becoming more refined, a process that is heavily dependent on a child's environment. This discovery opens the door to optimizing the experiences a child needs to provide themselves with a strong foundation for adulthood. The present article reviews the neurological changes that occur in middle childhood, their impact on overall development and how to implement this knowledge to augment a child's capabilities.

Facial rejuvenation with fillers: The dual plane technique

Directory of Open Access Journals (Sweden)

Giovanni Salti

2015-01-01

Full Text Available Background: Facial aging is characterized by skin changes, sagging and volume loss. Volume is frequently addressed with reabsorbable fillers like hyaluronic acid gels. Materials and Methods: From an anatomical point of view, the deep and superficial fat compartments evolve differently with aging in a rather predictable manner. Volume can therefore be restored following a technique based on restoring first the deep volumes and there after the superficial volumes. We called this strategy "dual plane". A series of 147 consecutive patients have been treated with fillers using the dual plane technique in the last five years. Results: An average of 4.25 session per patient has been carried out for a total of 625 treatment sessions. The average total amount of products used has been 12 ml per patient with an average amount per session of 3.75 ml. We had few and limited adverse events with this technique. Conclusion: The dual plane technique is an injection technique based on anatomical logics. Different types of products can be used according to the plane of injection and their rheology in order to obtain a natural result and few side effects.

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African Journals Online (AJOL)

This article examines the contributions of female dramatists to research in ... the issues that continue to rejuvenate the women's ideology and movement today. ... world of drama is more effective than in true life situation ... She searches and finds a job with the .... camaraderie, gender balance, victory of motherhood and.

Zunde raMambo as a traditional coping mechanism for the care of ...

African Journals Online (AJOL)

This study sought to examine the feasibility of rejuvenating and strategically repositioning the Zunde raMambo (King's granary) as a traditional orphans and vulnerable children (OVC) coping mechanism in Zimbabwe with a special reference to Gutu District. The study was motivated by the intellectual and theoretical paucity ...

Facial microcirculatory and biomechanical skin properties after single high energy (Er):YAG laser application.

Science.gov (United States)

Medved, Fabian; Wurm, Antonia; Held, Manuel

2017-12-01

Owing to skin aging and the growing demand for skin rejuvenation, minimal invasive aesthetic treatments such as laser procedures are increasingly coming into focus. However, until now, little has been known about the objective effects of these procedures with respect to skin microcirculation or changes in skin elasticity. Facial skin rejuvenation was performed on 32 volunteers using ablative Erbium: YAG laser. Skin microcirculation and skin elasticity have then been evaluated objectively. Microcirculation (flow, SO 2 , velocity, and rHB) has been analyzed before and directly after the laser session by using the O2C device. Skin elasticity has been evaluated by using the Cutometer device (Uf, Ua, Ur, and Ue) before and directly after the laser treatment, as well as 1 week and then 1, 3, and 6 months post treatment. Further, the outcome for the volunteers regarding their satisfactory level after laser treatment was evaluated. Twenty volunteers were available for a complete follow-up. Microcirculation displayed statistically significant increase in all values to 2 mm depth. The biomechanical skin parameter of firmness of skin displayed statistically significant improvement in superficial skin layer after 6 months. Concerning microcirculation and skin elasticity the ablative Erbium: YAG laser treatment revealed similar effects on the skin like a superficial burn injury. In contrast to the determined skin elasticity parameters, firmness of skin objectively revealed a skin tightening effect after 6 months. Along with the important epidermal effect, the suitability of ablative laser treatment for skin rejuvenation has been proved in a long-term follow-up. Lasers Surg. Med. 49:891-898, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.

Science.gov (United States)

Zhao, Pan; Sui, Bing-Dong; Liu, Nu; Lv, Ya-Jie; Zheng, Chen-Xi; Lu, Yong-Bo; Huang, Wen-Tao; Zhou, Cui-Hong; Chen, Ji; Pang, Dan-Lin; Fei, Dong-Dong; Xuan, Kun; Hu, Cheng-Hu; Jin, Yan

2017-10-01

Cutaneous wounds are among the most common soft tissue injuries and are particularly hard to heal in aging. Caloric restriction (CR) is well documented to extend longevity; pharmacologically, profound rejuvenative effects of CR mimetics have been uncovered, especially metformin (MET), resveratrol (RSV), and rapamycin (RAPA). However, locally applied impacts and functional differences of these agents on wound healing remain to be established. Here, we discovered that chronic topical administration of MET and RSV, but not RAPA, accelerated wound healing with improved epidermis, hair follicles, and collagen deposition in young rodents, and MET exerted more profound effects. Furthermore, locally applied MET and RSV improved vascularization of the wound beds, which were attributed to stimulation of adenosine monophosphate-activated protein kinase (AMPK) pathway, the key mediator of wound healing. Notably, in aged skin, AMPK pathway was inhibited, correlated with impaired vasculature and reduced healing ability. As therapeutic approaches, local treatments of MET and RSV prevented age-related AMPK suppression and angiogenic inhibition in wound beds. Moreover, in aged rats, rejuvenative effects of topically applied MET and RSV on cell viability of wound beds were confirmed, of which MET showed more prominent anti-aging effects. We further verified that only MET promoted wound healing and cutaneous integrity in aged skin. These findings clarified differential effects of CR-based anti-aging pharmacology in wound healing, identified critical angiogenic and rejuvenative mechanisms through AMPK pathway in both young and aged skin, and unraveled chronic local application of MET as the optimal and promising regenerative agent in treating cutaneous wound defects. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Relational Capabilities to Leverage New Knowledge: Managing Directors' Perceptions in UK and Portugal Old Industrial Regions

Science.gov (United States)

Martins, Jorge Tiago

2016-01-01

Purpose: Focusing on the specific context of two European old industrial regions--South Yorkshire (UK) and North Region of Portugal--this paper aims to identify and conceptualise a set of relational capabilities that business leaders perceive to play a key role in industrial rejuvenation. Design/Methodology/Approach: A qualitative research design…

Chaparral and associated ecosystems management: a 5-year research and development program

Science.gov (United States)

C. Eugene Conrad; George A. Roby; Serena C. Hunter

1986-01-01

Chaparral is the dominant vegetation in the wildlands of central and southern California. It has evolved fire adaptions that make it flammable and trigger postfire regeneration, thereby ensuring plant community rejuvenation. To provide a framework for chaparral-related research and accelerate development and demonstration of urgently needed management techniques, the...

Platelet-rich plasma in clinical practice | Siebert | South African ...

African Journals Online (AJOL)

PRP has also been used in orthopaedics for bone, tendon and muscle injuries, dentistry for dental implants, dermatology for wound healing, and in pathological conditions such as alopecia aereata. However, more recently, it has been used in the fast-growing field of aesthetic and anti-ageing medicine for skin rejuvenation.

Mindfulness, Therapy and Vocational Values: Exploring the Moral and Aesthetic Dimensions of Vocational Education and Training

Science.gov (United States)

Hyland, Terry

2011-01-01

The devaluation and debilitation of education in general and vocational education and training (VET) in particular has been explored and described in recent years by a wide range of critical commentators. Education stands in dire need of therapy, and this paper suggests a therapeutic process for rejuvenating and enhancing VET through attention to…

Assessment of the safety of aqueous extract of Aloe vera on ...

African Journals Online (AJOL)

Aghomotsegin

2015-07-29

Jul 29, 2015 ... Aloe vera is used both traditionally and packaged commercially in many regions of the world for several medicinal and or cosmetic purposes. It is claimed to have rejuvenating, moisturizing, healing or soothing properties on the skin and gastrointestinal tract. This study focused on assessment of the safety of ...

Assessment of the Safety of Aqueous Extract of Aloe vera on ...

African Journals Online (AJOL)

Aloe vera is used both traditionally and packaged commercially in many regions of the world for several medicinal and or cosmetic purposes. It is claimed to have rejuvenating, moisturizing, healing or soothing properties on the skin and gastrointestinal tract. This study focused on assessment of the safety of A. vera on blood ...

An Evaluation of the 'New History' Phenomenon | Moyo | Zimbabwe ...

African Journals Online (AJOL)

The purpose of this article was to evaluate the 'New History' approach. This paper explores the argument that the new 'New History' phenomenon was an attempt to rejuvenate an interest in History. The 'New History' phenomenon was launched because of the fear that History was in danger as it faced possible extinction ...

"Listen Then, Or, Rather, Answer": Contemporary Challenges to Socratic Education

Science.gov (United States)

Fullam, Jordan

2015-01-01

The popularity of Jacques Rancière in recent work in educational philosophy has rejuvenated discussion of the merits and weaknesses of Socratic education, both in Plato's dialogues and in invocations of Socrates in contemporary educational practice. In this essay Jordan Fullam explores the implications of this trend through comparing…

Let justice roll down like waters: Faith-based advocacy and water for ...

African Journals Online (AJOL)

The Paper essentially addresses the ecumenical importance of water as well as its overall utility to mankind. It argues that life is obviously meaningless without the commodity as every living creature derives his or her relevance from water. Furthermore, it recognizes that water has been a source of economic rejuvenation to ...

Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano

Directory of Open Access Journals (Sweden)

Braeckman Bart P

2009-07-01

Full Text Available Abstract Free-living flatworms ("Turbellaria" are appropriate model organisms to gain better insight into the role of stem cells in ageing and rejuvenation. Ageing research in flatworms is, however, still scarce. This is partly due to culture difficulties and the lack of a complete set of demographic data, including parameters such as median lifespan and age-specific mortality rate. In this paper, we report on the first flatworm survival analysis. We used the species Macrostomum lignano, which is an emerging model for studying the reciprocal influence between stem cells, ageing and rejuvenation. This species has a median lifespan of 205 ± 13 days (average ± standard deviation [SD] and a 90th percentile lifespan of 373 ± 32 days. The maximum lifespan, however, is more than 745 days, and the average survival curve is characterised by a long tail because a small number of individuals lives twice as long as 90% of the population. Similar to earlier observations in a wide range of animals, in M. lignano the age-specific mortality rate increases exponentially, but levels off at the oldest ages. To compare the senescence of M. lignano with that of other ageing models, we determined the mortality rate doubling time, which is 0.20 ± 0.02 years. As a result, we can conclude that M. lignano shows gradual senescence at a rate similar to the vertebrate ageing models Rattus norvegicus and Mus musculus. We argue that M. lignano is a suitable model for ageing and rejuvenation research, and especially for the role of stem cells in these processes, due to its accessible stem cell system and regeneration capacity, and the possibility of combining stem cell studies with demographic analyses.

Some alternatives to the mixed oxide fuel cycle

International Nuclear Information System (INIS)

Deonigi, D.E.; Eschbach, E.A.; Goldsmith, S.; Pankaskie, P.J.; Rohrmann, C.A.; Widrig, R.D.

1977-02-01

While on initial examination each of the six fuel cycle concepts (tandem cycle, extended burnup, fuel rejuvenation, coprocessing, partial reprocessing, and thorium) described in the report may have some potential for improving safeguards, none of the six appears to have any other major or compelling advantages over the mixed oxide (MOX) fuel cycle. Compared to the MOX cycle, all but coprocessing appear to have major disadvantages, including severe cost penalties. Three of the concepts-tandem, extended burnup, and rejuvenation--share the basic problems of the throwaway cycle (GESMO Alternative 6): without reprocessing, high-level waste volumes and costs are substantially increased, and overall uranium utilization decreases for three reasons. First, the parasitic fission products left in the fuel absorb neutrons in later irradiation steps reducing the overall neutronic efficiencies of these cycles. Second, discarded fuel still has sufficient fissile values to warrant recycle. Third, perhaps most important, the plutonium needed for breeder start-up will not be available; without the breeder, uranium utilization would drop by about a factor of sixty. Two of the concepts--coprocessing and partial reprocessing--involve variations of the basic MOX fuel cycle's chemical reprocessing step to make plutonium diversion potentially more difficult. These concepts could be used with the MOX fuel cycle or in conjunction with the tandem, extended burnup and rejuvenation concepts to eliminate some of the problems with those cycles. But in so doing, the basic impetus for those cycles--elimination of reprocessing for safeguards purposes--no longer exists. Of all the concepts considered, only coprocessing--and particularly the ''master blend'' version--appears to have sufficient promise to warrant a more detailed study. The master blend concept could possibly make plutonium diversion more difficult with minimal impact on the reprocessing and MOX fuel fabrication operations

The effects of ontogenetic maturation in Pinus patula - part 1 ...

African Journals Online (AJOL)

This paper forms the first component of a three-part series and reports on those effects observed in the nursery. The effects of hedge maturation on field performance and cycling of P. patula hedges as a means of rejuvenation, are reported separately. An analysis of the nursery data indicates that rooting efficiency, root ...

40 CFR Table 28 to Subpart Uuu of... - Continuous Compliance With Operating Limits for Inorganic HAP Emissions From Catalytic Reforming...

Science.gov (United States)

2010-07-01

... rejuvenation by . . . 1. Wet scrubber a. The daily average pH or alkalinity of the water (or scrubbing liquid... HCl reduction standard a. The daily average pH or alkalinity of the water (or scrubbing liquid... hourly and daily average pH or alkalinity monitoring data according to § 63.1572 1; and maintaining the...

Platelet rich plasma in dermatology and aesthetic medicine

OpenAIRE

Neerja Puri

2015-01-01

Platelet rich plasma is a promising therapy in dermatology and aesthetic medicine. In this article we will discuss the pros and cons of platelet rich plasma (PRP) and the usage of PRP in aesthetics. PRP is especially used for conditions like facial and neck rejuvenation, fine lines and wrinkles, abdominal striae and facial scarring.

The Anatomy of the Aging Face: A Review.

Science.gov (United States)

Cotofana, Sebastian; Fratila, Alina A M; Schenck, Thilo L; Redka-Swoboda, Wolfgang; Zilinsky, Isaac; Pavicic, Tatjana

2016-06-01

Rejuvenative procedures of the face are increasing in numbers, and a plethora of different therapeutic options are available today. Every procedure should aim for the patient's safety first and then for natural and long-lasting results. The face is one of the most complex regions in the human body and research continuously reveals new insights into the complex interplay of the different participating structures. Bone, ligaments, muscles, fat, and skin are the key players in the layered arrangement of the face.Aging occurs in all involved facial structures but the onset and the speed of age-related changes differ between each specific structure, between each individual, and between different ethnic groups. Therefore, knowledge of age-related anatomy is crucial for a physician's work when trying to restore a youthful face.This review focuses on the current understanding of the anatomy of the human face and tries to elucidate the morphological changes during aging of bone, ligaments, muscles, and fat, and their role in rejuvenative procedures. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Aging well--the role of minimally invasive aesthetic dermatological procedures in women over 65.

Science.gov (United States)

Wollina, Uwe; Payne, Christopher Rowland

2010-03-01

The western world is getting older. Aging well has become the new target of preventative medicine. Aesthetic dermatology can contribute to this quest. Females over 65 represent an important and growing group of consumers of cosmetic procedures. In this group, there is a paucity of scientific evaluation of aesthetic procedures. To review the use of minimally invasive procedures for facial rejuvenation in women over 65. Drawing from both the literature and personal experience, the opportunities, modifications, and limitations of minimally invasive techniques for facial rejuvenation in older women are considered. In this older age group, dermal fillers, chemical and laser peels, and nonablative photorejuvenation remain useful and can each be used as stand-alone treatments. In this age group, botulinum toxin (BTX) injections are more often used in combination with other procedures. With respect to aesthetic procedures, women over 65 are different from younger women. More scientific investigation is necessary to better meet needs of this growing part of the population. Available data suggest that aesthetic dermatology can make a major contribution to the complex matter of aging well.

Kelvin probe studies of cesium telluride photocathode for AWA photoinjector

Energy Technology Data Exchange (ETDEWEB)

Wisniewski, Eric E., E-mail: ewisniew@anl.gov [High Energy Physics Division, Argonne National Laboratory, 9700 S. Cass, Lemont, IL 60439 (United States); Physics Department, Illinois Institute of Technology, 3300 South Federal Street, Chicago, IL 60616 (United States); Velazquez, Daniel [High Energy Physics Division, Argonne National Laboratory, 9700 S. Cass, Lemont, IL 60439 (United States); Physics Department, Illinois Institute of Technology, 3300 South Federal Street, Chicago, IL 60616 (United States); Yusof, Zikri, E-mail: zyusof@hawk.iit.edu [High Energy Physics Division, Argonne National Laboratory, 9700 S. Cass, Lemont, IL 60439 (United States); Physics Department, Illinois Institute of Technology, 3300 South Federal Street, Chicago, IL 60616 (United States); Spentzouris, Linda; Terry, Jeff [Physics Department, Illinois Institute of Technology, 3300 South Federal Street, Chicago, IL 60616 (United States); Sarkar, Tapash J. [Rice University, 6100 Main, Houston, TX 77005 (United States); Harkay, Katherine [Accelerator Science Division, Argonne National Laboratory, 9700 S. Cass, Lemont, IL 60439 (United States)

2013-05-21

Cesium telluride is an important photocathode as an electron source for particle accelerators. It has a relatively high quantum efficiency (>1%), is sufficiently robust in a photoinjector, and has a long lifetime. This photocathode is grown in-house for a new Argonne Wakefield Accelerator (AWA) beamline to produce high charge per bunch (≈50nC) in a long bunch train. Here, we present a study of the work function of cesium telluride photocathode using the Kelvin probe technique. The study includes an investigation of the correlation between the quantum efficiency and the work function, the effect of photocathode aging, the effect of UV exposure on the work function, and the evolution of the work function during and after photocathode rejuvenation via heating. -- Highlights: ► The correlation between Quantum Efficiency (QE) and work function. ► How QE and work function evolve together. ► Rejuvenation of the photocathode via heating and the effect on work function. ► The effects on the work function due to exposure to UV light.

Face expressive lifting (FEL): an original surgical concept combined with bipolar radiofrequency.

Science.gov (United States)

Divaris, Marc; Blugerman, Guillermo; Paul, Malcolm D

2014-01-01

Aging can lead to changes in facial expressions, transforming the positive youth expression of happiness to negative expressions as sadness, tiredness, and disgust. Local skin distension is another consequence of aging, which can be difficult to treat with rejuvenation procedures. The "face expressive lifting" (FEL) is an original concept in facial rejuvenation surgery. On the one hand, FEL integrates established convergent surgical techniques aiming to correct the age-related negative facial expressions. On the other hand, FEL incorporates novel bipolar RF technology aiming to correct local skin distension. One hundred twenty-six patients underwent FEL procedure. Facial expression and local skin distension were assessed with 2 years follow-up. There was a correction of negative facial expression for 96 patients (76 %) and a tightening of local skin distension in 100 % of cases. FEL is an effective procedure taking into account and able to correct both age-related negative changes in facial expression and local skin distension using radiofrequency. Level of Evidence: Level IV, therapeutic study.

Evolutionary perspectives on ageing

Czech Academy of Sciences Publication Activity Database

Reichard, Martin

2017-01-01

Roč. 70, SI (2017), s. 99-107 ISSN 1084-9521 R&D Projects: GA ČR(CZ) GA16-00291S Institutional support: RVO:68081766 Keywords : Gene-by-environment interactions * Germ-soma distinction * Intraspecific ageing rate * Modified mutation accumulation * Rejuvenation * Retrogression Subject RIV: EG - Zoology OBOR OECD: Developmental biology Impact factor: 6.614, year: 2016

The Lysosome, Elixir of Neural Stem Cell Youth.

Science.gov (United States)

Simic, Milos S; Dillin, Andrew

2018-05-03

Recently in Science, Leeman et al. find that perturbing lysosomal activity of quiescent NSCs directly impedes their ability to become activated, similar to what happens during aging. Excitingly, they could rejuvenate old quiescent NSCs by enhancing the lysosome pathway, ameliorating their ability to clear protein aggregates and become activated. Copyright © 2018. Published by Elsevier Inc.

Platelet rich plasma in dermatology and aesthetic medicine

Directory of Open Access Journals (Sweden)

Neerja Puri

2015-04-01

Full Text Available Platelet rich plasma is a promising therapy in dermatology and aesthetic medicine. In this article we will discuss the pros and cons of platelet rich plasma (PRP and the usage of PRP in aesthetics. PRP is especially used for conditions like facial and neck rejuvenation, fine lines and wrinkles, abdominal striae and facial scarring.

The radiofrequency frontier: a review of radiofrequency and combined radiofrequency pulsed-light technology in aesthetic medicine.

Science.gov (United States)

Sadick, Neil; Sorhaindo, Lian

2005-05-01

Radiofrequency (RF) and combined RF light source technologies have established themselves as safe and effective treatment modalities for several dermatologic procedures, including skin tightening, hair and leg vein removal, acne scarring, skin rejuvenation, and wrinkle reduction. This article reviews the technology, clinical applications, and recent advances of RF and combined RF light/laser source technologies in aesthetic medicine.

A new RF system for a rejuvenated Synchro-cyclotron

CERN Multimedia

1975-01-01

The Synchro-cyclotron is shown here shortly after the completion of the improvement programme, which left the steel magnet yoke as almost the only remaining component of the original machine. On the left can be seen the rotary condenser which produces the frequency modulation required for the acceleration (one of a pair available -in this instance ROTCO II). (see photo 7506015)

REJUVENATING CHRONIC DISEASE MANAGEMENT IN MALAYSIAN PRIVATE GENERAL PRACTICE

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PITERMAN L

2010-01-01

Full Text Available Rapid epidemiological transition globally has witnessed a rising prevalence of major chronic diseases such as hypertension, diabetes, hyperlipidaemia, obesity, chronic respiratory diseases and cancers over the past 30 years. In Malaysia, these conditions are commonly managed in primary care and published evidence has consistently shown suboptimal management and poor disease control. This in turn, has led to the massive burden of treating complications in secondary care, burden tothe patients and their families with regards to morbidity and premature death, and burden to the country with regards to premature loss of human capital. The crushing burden and escalating health care costs in managing chronic diseases pose a daunting challenge to our primary care system, as we remain traditionally oriented to care for acute, episodic illnesses. This paper re-examines the current evidence supporting the implementation of Wagner Chronic Care Model in primary careglobally; analyses the barriers of implementation of this model in the Malaysian private general practice through SWOT(strengths, weaknesses, opportunities and threats analysis; and discusses fundamental solutions needed to bridge the gap to achieve better outcomes.

Periorbital facial rejuvenation; applied anatomy and pre-operative assessment

Directory of Open Access Journals (Sweden)

Mohsen Bahmani Kashkouli

2017-09-01

Conclusion: Static and dynamic aging changes of the periorbital area should be assessed as an eyelid-eyebrow unit paying more attention to the anthropometric landmarks. Assessing the facial asymmetry, performing comprehensive and detailed ocular examination, and asking about patients' expectation are three key elements in this regard. Furthermore, taking standard facial pictures, obtaining special consent form, and finally getting feedback are also indispensable tools toward a better outcome.

Rejuvenating Strategies for Stem Cell-based Therapies in Aging

Science.gov (United States)

Neves, Joana; Sousa-Victor, Pedro; Jasper, Heinrich

2017-01-01

SUMMARY Recent advances in our understanding of tissue regeneration and the development of efficient approaches to induce and differentiate pluripotent stem cells for cell replacement therapies promise exciting avenues for treating degenerative age-related diseases. However, clinical studies and insights from model organisms have identified major roadblocks that normal aging processes impose on tissue regeneration. These new insights suggest that specific targeting of environmental niche components, including growth factors, ECM and immune cells, and intrinsic stem cell properties that are affected by aging will be critical for development of new strategies to improve stem cell function and optimize tissue repair processes. PMID:28157498

Molecular aging and rejuvenation of human muscle stem cells

DEFF Research Database (Denmark)

Carlson, Morgan E; Suetta, Charlotte; Conboy, Michael J

2009-01-01

. Our findings establish key evolutionarily conserved mechanisms of human stem cell aging. We find that satellite cells are maintained in aged human skeletal muscle, but fail to activate in response to muscle attrition, due to diminished activation of Notch compounded by elevated transforming growth...... factor beta (TGF-beta)/phospho Smad3 (pSmad3). Furthermore, this work reveals that mitogen-activated protein kinase (MAPK)/phosphate extracellular signal-regulated kinase (pERK) signalling declines in human muscle with age, and is important for activating Notch in human muscle stem cells. This molecular......Very little remains known about the regulation of human organ stem cells (in general, and during the aging process), and most previous data were collected in short-lived rodents. We examined whether stem cell aging in rodents could be extrapolated to genetically and environmentally variable humans...

Aging and rejuvenation of active matter under topological constraints

NARCIS (Netherlands)

Janssen, L.M.C.; Kaiser, A.; Löwen, H.W.

2017-01-01

The coupling of active, self-motile particles to topological constraints can give rise to novel non-equilibrium dynamical patterns that lack any passive counterpart. Here we study the behavior of self-propelled rods confined to a compact spherical manifold by means of Brownian dynamics simulations.

Rejuvenation of the anion exchanger used for uranium recovery

International Nuclear Information System (INIS)

Yan, T.-Y.; Espenscheid, W.F.

1986-01-01

The present invention is directed to improving the performance of strong base anionic exchange resins used in uranium recovery that exhibit an undesirable decrease in loading capacity and in total exchange capacity. The invention comprises treating an anionic exchange resin to remove physically adsorbed and occluded fouling agents and to remove poisons which may be chemically bound to active ion groups on the resin. The process involves treating the resin, after the uranium ion exchange stage, with an alkaline carbonate solution, preferably treating the resin with an acid eluant first. The acid treatment dissolves insoluble fouling agents which are physically occluded or adsorbed by the resin and that the weak base treatment augments that result and probably removes poisons which are physically or chemically bound to the resin

A case of recovery from dementia following rejuvenative treatment.

Science.gov (United States)

Prokopov, Arkadi F

2010-01-01

A female patient born in 1931 suffered mental decline for about 1 year. She could no longer conduct her usual activities and home chores and could not hear without a hearing aid. Brain magnetic resonance imaging (MRI) performed in February, 2008, revealed degenerative changes. Treatment consisted of repeated sessions of intermittent hypoxic training (IHT), and individualized vitamins, amino acids, microelements, supplementation, and nutritional adjustment. Until April, 2009, the patient had completed four cycles of IHT and 8 months of the supplementation program. The patient gradually recovered her healthy mental state; she resumed shopping and cooking and began playing piano again, which she was not capable of doing last year. An MRI of her brain performed during April, 2009, showed no degenerative changes.

Towards a doubly reflexive ethnography: A proposal from the anthropology of interculturality

OpenAIRE

Gunther Dietz

2011-01-01

Starting from the contemporary debate on ethnographic methodology in anthropology, this paper analyses how new methodological options arise throughout processes of educational interculturality and how these can nourish, rejuvenate and decolonize classica anthropological ethnography. The contrast between a postmodern anthropology and activist ethnography reveals possibilities for fruitfully complement social and political en gagement with the classical canon of ethnography, which ...

Biomedical Progress Rates as New Parameters for Models of Economic Growth in Developed Countries

Directory of Open Access Journals (Sweden)

Alex Zhavoronkov

2013-11-01

Full Text Available While the doubling of life expectancy in developed countries during the 20th century can be attributed mostly to decreases in child mortality, the trillions of dollars spent on biomedical research by governments, foundations and corporations over the past sixty years are also yielding longevity dividends in both working and retired population. Biomedical progress will likely increase the healthy productive lifespan and the number of years of government support in the old age. In this paper we introduce several new parameters that can be applied to established models of economic growth: the biomedical progress rate, the rate of clinical adoption and the rate of change in retirement age. The biomedical progress rate is comprised of the rejuvenation rate (extending the productive lifespan and the non-rejuvenating rate (extending the lifespan beyond the age at which the net contribution to the economy becomes negative. While staying within the neoclassical economics framework and extending the overlapping generations (OLG growth model and assumptions from the life cycle theory of saving behavior, we provide an example of the relations between these new parameters in the context of demographics, labor, households and the firm.

Biomedical progress rates as new parameters for models of economic growth in developed countries.

Science.gov (United States)

Zhavoronkov, Alex; Litovchenko, Maria

2013-11-08

While the doubling of life expectancy in developed countries during the 20th century can be attributed mostly to decreases in child mortality, the trillions of dollars spent on biomedical research by governments, foundations and corporations over the past sixty years are also yielding longevity dividends in both working and retired population. Biomedical progress will likely increase the healthy productive lifespan and the number of years of government support in the old age. In this paper we introduce several new parameters that can be applied to established models of economic growth: the biomedical progress rate, the rate of clinical adoption and the rate of change in retirement age. The biomedical progress rate is comprised of the rejuvenation rate (extending the productive lifespan) and the non-rejuvenating rate (extending the lifespan beyond the age at which the net contribution to the economy becomes negative). While staying within the neoclassical economics framework and extending the overlapping generations (OLG) growth model and assumptions from the life cycle theory of saving behavior, we provide an example of the relations between these new parameters in the context of demographics, labor, households and the firm.

Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

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Hemant K. Singh

2013-02-01

Full Text Available Āyurveda, the science (ved of life (ayu, owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. Āyurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics. The symptoms of various brain disorders, including memory disorder, were well defined. The goal of Āyurveda was to help an individual to achieve his cherished goal of leading a healthy life of 100 years. To achieve this, great emphasis was laid on nutrition, diet and a good conduct by the two great exponents of Āyurveda viz. Carak and Suśruta. By following these regimens, an individual could lead a less stressful life free from emotional disturbances. Both Carak and Suśruta had believed that these in combination with rasayana (rejuvenating plants could enable an individual to lead a healthy life of 100 years.

Brain enhancing ingredients from Āyurvedic medicine: quintessential example of Bacopa monniera, a narrative review.

Science.gov (United States)

Singh, Hemant K

2013-02-06

Āyurveda, the science (ved) of life (ayu), owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. Āyurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry) and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics. The symptoms of various brain disorders, including memory disorder, were well defined. The goal of Āyurveda was to help an individual to achieve his cherished goal of leading a healthy life of 100 years. To achieve this, great emphasis was laid on nutrition, diet and a good conduct by the two great exponents of Āyurveda viz. Carak and Suśruta. By following these regimens, an individual could lead a less stressful life free from emotional disturbances. Both Carak and Suśruta had believed that these in combination with rasayana (rejuvenating) plants could enable an individual to lead a healthy life of 100 years.

Cutaneous remodeling and photorejuvenation using radiofrequency devices

Directory of Open Access Journals (Sweden)

Elsaie Mohamed

2009-01-01

Full Text Available Radio frequency (RF is electromagnetic radiation in the frequency range of 3-300GHz. The primary effects of RF energy on living tissue are considered to be thermal. The goal of the new devices based on these frequency ranges is to heat specific layers of the skin. The directed use of RF can induce dermal heating and cause collagen degeneration. Wound healing mechanisms promote the remodeling of collagen and wound contraction, which ultimately clinically enhances the appearance of mild to moderate skin laxity. Preliminary studies have reported efficacy in the treatment of laxity that involves the periorbital area and jowls. Because RF energy is not dependent on specific chromophore interaction, epidermal melanin is not at risk of destruction and treatment of all skin types is possible. As such, radiofrequency-based systems have been used successfully for nonablative skin rejuvenation, atrophic scar revision and treatment of unwanted hair, vascular lesions and inflammatory acne. The use of RF is becoming more popular, although a misunderstanding exists regarding the mechanisms and limitations of its actions. This concise review serves as an introduction and guide to many aspects of RF in the non ablative rejuvenation of skin.

Structural manifestations of aging in Se-rich glasses

Science.gov (United States)

Dash, S.; Ravindren, S.; Chen, P.; Boolchand, P.

2015-03-01

We examine weakly cross-linked GexSe100-x (0%modulated DSC and Raman scattering experiments. Homogeneity of melts was carefully verified using FT-Raman line profiling. Upon aging at RT for 4 months, we find the width of the glass transition W(x) steadily decreasing from 10C at 7% Ge to 2C for pure Se. The 5-fold reduction of W(x) with a decrease of Ge content is accompanied by a 2-fold increase in the non-reversing enthalpy. Rejuvenation of the aged glasses changes W(x) from 15C at 7% Ge to 7C for pure Se. Tg is found to decrease upon rejuvenation with the difference (Tg(aged)-Tg(rejuv)) showing a maximum near 3% Ge and vanishing for pure Se and 6% of Ge, which are topological thresholds. These results in Se-rich glasses are consistent with aging induced decoupling of Se8 crowns and growth of extended range structural correlations between polymeric Sen chains due to lone pair interactions. At higher x, near 8-10% of Ge, eutectic effects are manifested. Work supported by NSF Grant DMR 08-53957.

Impact of aging immune system on neurodegeneration and potential immunotherapies.

Science.gov (United States)

Liang, Zhanfeng; Zhao, Yang; Ruan, Linhui; Zhu, Linnan; Jin, Kunlin; Zhuge, Qichuan; Su, Dong-Ming; Zhao, Yong

2017-10-01

The interaction between the nervous and immune systems during aging is an area of avid interest, but many aspects remain unclear. This is due, not only to the complexity of the aging process, but also to a mutual dependency and reciprocal causation of alterations and diseases between both the nervous and immune systems. Aging of the brain drives whole body systemic aging, including aging-related changes of the immune system. In turn, the immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution that are sources of chronic inflammation in the elderly (termed inflammaging), potentially induces brain aging and memory loss in a reciprocal manner. Therefore, immunotherapeutics including modulation of inflammation, vaccination, cellular immune therapies and "protective autoimmunity" provide promising approaches to rejuvenate neuroinflammatory disorders and repair brain injury. In this review, we summarize recent discoveries linking the aging immune system with the development of neurodegeneration. Additionally, we discuss potential rejuvenation strategies, focusing aimed at targeting the aging immune system in an effort to prevent acute brain injury and chronic neurodegeneration during aging. Copyright © 2017 Elsevier Ltd. All rights reserved.

Systematic review of the use of platelet-rich plasma in aesthetic dermatology.

Science.gov (United States)

Leo, Michael S; Kumar, Alur S; Kirit, Raj; Konathan, Rajyalaxmi; Sivamani, Raja K

2015-12-01

Platelet-rich plasma (PRP) is a highly concentrated autologous solution of plasma prepared from a patient's own blood. PRP contains platelets that are purported to release numerous growth factors that may be valuable in numerous dermatologic applications. Here, we review systematically the clinical cosmetic applications of PRP including: androgenetic alopecia, scar revision, acne scars, skin rejuvenation, dermal augmentation, and striae distensae to understand the potential and best practices for PRP use. A systematic search was conducted on three databases: Pubmed, Embase, and Web of Science. Publications were included if they were in English, investigated the clinical applications of PRP in aesthetic dermatology and reported clinical results either as case reports or clinical studies. There were a total of 22 manuscripts that fulfilled these criteria. Four evaluated hair-related applications, eight evaluated the treatment of scars and postprocedure recovery, eight evaluated skin rejuvenation and dermal augmentation, and two evaluated treatment of striae distensae. PRP is a relatively new treatment modality with studies suggesting its utility in aesthetic dermatology. The combination of PRP with other therapies is particularly interesting. Future studies should include controls, including incorporation of split-face comparisons, to reduce intersubject variability. © 2015 Wiley Periodicals, Inc.

Interfacing the septa movement (DC motors) equipment to the PS control system and the MIL1553 bus

CERN Document Server

Dehavay, Claude

1995-01-01

Continuing the rejuvenation of the PS Control system , this application replaces the Single Transceiver Hybrid used to interface the Septa Movement Fquipment by a G64 system connected to the VME crate via the MIL1553 bus. This note explains the G64 hardware interface and details the standard message as defined in the Control Protocole for Power Converter, RF and Stepping Motor equipment.

Interfacing the septa movement (DC motor) equipment to the PS control system and the MIL1553 bus

CERN Document Server

Dehavay, Claude

1993-01-01

Continuing the rejuvenation of the PS Control system , it is planned to replace the Single Transceiver Hybrid used to interface the Septa Movement Equipment by a G64 system connected to the VME crate via the MIL1553 bus. This note explains the G64 hardware interface and details the standard message as defined in the Control Protocole for Power Converter, RF and Stepping Motor equipment.

Investigating whether a lack of marketing and managerial skills is the main cause of business failure in South Africa

Directory of Open Access Journals (Sweden)

S Radipere

2014-07-01

The study concludes that a lack of marketing and managerial skills has a negative impact on the success, viability and development of small businesses.  The challenge is to improve the managerial skills of small business owners, since the small business sector is widely considered to be the ideal site for the solving of South Africa’s unemployment problems and the rejuvenation of its stagnating economy.

Combined aesthetic interventions for prevention of facial ageing, and restoration and beautification of face and body

Directory of Open Access Journals (Sweden)

Fabi S

2017-10-01

Full Text Available Sabrina Fabi,1 Tatjana Pavicic,2 André Braz,3 Jeremy B Green,4,5 Kyle Seo,6 Jani AJ van Loghem7 1Cosmetic Laser Dermatology, San Diego, CA, USA; 2Private Practice for Dermatology and Aesthetics, Munich, Germany; 3Division of the Policlínica Geral do Rio de Janeiro (PGRJ, Rio de Janeiro, Brazil; 4Skin Associates of South Florida, Miami, 5University of Miami Department of Dermatology, Miami, FL, USA; 6Seoul National University, Seoul, South Korea; 7Doctors Inc., Amsterdam, The Netherlands Abstract: The Merz Institute of Advanced Aesthetics Expert Summit was held in Prague, Czech Republic, from 19–20 November 2016. The meeting had a distinct advisory board character and invited aesthetic practitioners from all over the world to hear an international faculty present a range of keynote lectures and conduct live injection sessions with an emphasis on recent developments in combination aesthetic interventions for face and body rejuvenation and beautification. Aging is associated with changes in bones, muscles, ligaments, adipose tissue, and skin and, moreover, involves interactions among these tissue types. To achieve the most natural and harmonious rejuvenation of the face, all changes that result from the aging process should be corrected, which generally involves treatment with more than a single agent or technology. Presentations described innovative treatment algorithms for the face and body and focused on patients’ desires for natural-looking rejuvenation and how this requires a three-dimensional approach combining products that relax the musculature, volumize, and re-drape the skin. Besides treating the aging face, these procedures are increasingly used to enhance facial features as well as to delay facial aging in younger patients. The presentations covered patients from different ethnicities as well as the treatment of non-facial areas, with a particular focus on the use of Ultherapy® for skin lifting and tightening, and new aesthetic

Passivation of bimetallic catalysts used in water treatment: prevention and reactivation.

Science.gov (United States)

Chen, Jianming; Gillham, Robert W; Gui, Lai

2013-01-01

With respect to degradation rates and the range in contaminants treated, bimetals such as Ni-Fe or Pd-Fe generally outperform unamended granular iron. However, the catalytic enhancement is generally short-lived, lasting from a few days to months. To take advantage of the significant benefits of bimetals, this study aims at developing an effective method for the rejuvenation of passivated bimetals and alternatively, the prevention of rapid reactivity loss of bimetals. Because the most likely cause of Ni-Fe and Pd-Fe passivation is the deposition of iron oxide films over the catalyst sites, it is hypothesized that removal of the iron oxide films will restore the lost reactivity or avoiding the deposition of iron oxide films will prevent passivation. Two organic ligands (ethylenediaminetetraacetic acid (EDTA), and [s,s]-ethylenediaminedisuccinate acid ([s,s]-EDDS)) and two acids (citric acid and sulphuric acid) were tested as possible chemical reagents for both passivation rejuvenation and prevention. Trichloroethene (TCE) and Ni-Fe were chosen as probes for chlorinated solvents and bimetals respectively. The test was carried out using small glass columns packed with Ni-Fe. TCE solution containing a single reagent at various concentrations was pumped through the Ni-Fe columns with a residence time in the Ni-Fe of about 6.6 min. TCE concentrations in the influent and effluent were measured to evaluate the performance of each chemical reagent. The results show that (i) for passivated Ni-Fe, flushing with a low concentration of acid or ligand solution without mechanical mixing can fully restore the lost reactivity; and (ii) for passivation prevention, adding a small amount of a ligand or an acid to the feed solution can successfully prevent or at least substantially reduce Ni-Fe passivation. All four chemicals tested are effective in both rejuvenation and prevention, but sulphuric acid and citric acid are considered to be the most practical reagents due to their

The Zebrafish Models to Explore Genetic and Epigenetic Impacts on Evolutionary Developmental Origins of Aging

Science.gov (United States)

Kishi, Shuji

2014-01-01

Can we reset, reprogram, rejuvenate or reverse the organismal aging process? Certain genetic manipulations could at least reset and reprogram epigenetic dynamics beyond phenotypic plasticity and elasticity in cells, which can be further manipulated into organisms. However, in a whole complex aging organism, how can we rejuvenate intrinsic resources and infrastructures in an intact/noninvasive manner? The incidence of diseases increases exponentially with age, accompanied by progressive deteriorations of physiological functions in organisms. Aging-associated diseases are sporadic but essentially inevitable complications arising from senescence. Senescence is often considered the antithesis of early development, but yet there may be factors and mechanisms in common between these two phenomena to rejuvenate over the dynamic process of aging. The association between early development and late-onset disease with advancing age is thought to come from a consequence of developmental plasticity, the phenomenon by which one genotype can give rise to a range of physiologically and/or morphologically adaptive states based on diverse epigenotypes, in response to intrinsic or extrinsic environmental cues and genetic perturbations. We hypothesized that the future aging process can be predictive based on adaptivity during the early developmental period. Modulating the thresholds and windows of plasticity and its robustness by molecular genetic and chemical epigenetic approaches, we have successfully conducted experiments to isolate zebrafish mutants expressing apparently altered senescence phenotypes during their embryonic and/or larval stages (“embryonic/larval senescence”). Subsequently, at least some of these mutant animals were found to show shortened lifespan, while some others would be expected to live longer in adulthoods. We anticipate that previously uncharacterized developmental genes may mediate the aging process and play a pivotal role in senescence. On the other

Patient retention and replacement trends after saline breast implants: are deflations inflationary?

Science.gov (United States)

Stevens, W Grant; Pacella, Salvatore J; Hirsch, Elliot; Stoker, David A

2009-01-01

This study aimed to examine serial operative trends with patients who have experienced surgical implant deflation. In addition, the economic impact of deflation on practice caseload was analyzed. A retrospective review was conducted to examine patients who experienced deflation from 2000 to 2007. Patient demographics, implant data, and the presence of secondary (performed at explantation) or tertiary (performed later) procedures were examined. Financial information was tabulated to determine the economic multiplier effect (i.e. the expected value of revenue from secondary and tertiary procedures divided by explantation cost) of taking on deflation cases in a practice. For this study, 285 patients with an average age of 38.4 years were identified. The average time to explantation was 50 months. Slightly more than half of the patients (55%) had both implants replaced at the time of explantation, whereas 59% switched to silicone implants and 41% continued with saline implants. A larger implant was chosen by 54% of the patients (average increase, 82 ml), whereas 18% underwent secondary procedures at the time of explantation including mastopexy (n = 22), facial rejuvenation (n = 8), liposuction (n = 7), or a combination of the two (n = 8). Tertiary procedures were performed for 31% of the patients after their explantation/reimplantation (average time frame, 13 months). The tertiary procedures included replacement with silicone (33.7%), liposuction (24.7%), abdominoplasty (11.2%), facial rejuvenation (13.5%), or nonsurgical rejuvenation using Botox, Restylane, or laser procedure (33.7%). Economic multiplier analysis showed that the financial impact of revenue derived from implant deflation on downstream practice revenue is 1.02. At the time of explantation, replacement with silicone after saline deflation is common (59% of patients). In this study, patients who chose replacement with saline had a significant tendency to replace with silicone (33%) as a tertiary procedure

The percutaneous trampoline platysmaplasty: technique and experience with 105 consecutive patients.

Science.gov (United States)

Mueller, Gregory P; Leaf, Norman; Aston, Sherrell J; Stone, Corbett W

2012-01-01

Controversy persists regarding the optimal procedure to rejuvenate the aging neck. More invasive procedures carry increased risks of complications, whereas less invasive approaches may deliver marginal results. The challenge is selecting the appropriate procedure for delivering consistent, durable results meeting both the patient's and surgeon's expectations. The authors describe their trampoline platysmaplasty (TPP) approach, a percutaneous suture suspension necklift that constitutes a less invasive approach for neck rejuvenation. A retrospective study was conducted of 105 consecutive patients who underwent TPP. Age, sex, procedure(s) performed, complications, and patient satisfaction were recorded. Cadaver studies were conducted to compare the tensile strength of the ligaments that anchor the TPP to the tensile strength of the sutures placed to approximate the medial platysma borders. In addition, the accuracy of light transillumination to determine depth of travel of the light-emitting diode (LED) lighted rod was evaluated. Patients underwent either TPP alone (18 women, 24 men) or TPP with a facelift (35 women, 28 men) between October 2007 and June 2009. The average age of the patients was 52 years, and average length of follow-up was 33 months. Patient satisfaction was high. Three early patients underwent immediate revision to improve results secondary to the suture matrix being too loose. Six additional patients had recurrent banding around one year postoperatively, but correction was achieved in all six by replacing the matrix with the help of the lighted rod. The results of the cadaver study revealed that the tensile strength of the retaining ligaments was statistically identical to the medial platysma borders, and the light transillumination feedback was accurate with regard to the depth of travel of the illuminated rod tip. The TPP approach for neck rejuvenation is effective and durable in properly-selected patients. It works well as a stand

Lipofilling With Minimal Access Cranial Suspension Lifting for Enhanced Rejuvenation

NARCIS (Netherlands)

Willemsen, Joep C. N.; Mulder, Karlijn M.; Stevens, Hieronymus P. J. D.

Background: Loss of volume is an important aspect in facial aging, but its relevance is frequently neglected during treatment. Objectives: The authors discuss lipofilling as an ancillary procedure to improve the impact of facelifting procedures. Methods: Fifty patients who underwent minimal access

[Facial rejuvenation and concentric malar lift: the FACE RECURVE concept].

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Le Louarn, C; Buthiau, D; Buis, J

2006-04-01

Cell ageing is responsible for the increasingly creased appearance of our skin. The ageing of the structures of the face is attributed primarily to the effect of gravity on the tissues. The theory expounded below sets out to prove that the main and initial cause of this ageing is the repeated contractions of the mimic muscles. This concept attributes only a secondary role to gravity in the ageing process, which is initially brought about by muscular contractions. An MRI study recently made it possible to demonstrate the anterior convexity curve of the mimic muscles in the young subject. This curve is due to the existence at the back of these muscles of a deep fat pad. In the young subject, the extent of its convexity and its location give a specific, youthful character to the movements, in terms of direction and amplitude, of the facial muscles. With age, the muscle gradually straightens and shortens due to the repeated contractions that expel the underlying fat and increase the tonus at rest. The application of these new findings to the ageing of the face gives rise to new technical possibilities both in the field of medicine and aesthetic surgery. These new techniques have the same targets: segments of the mimic muscles (maintain over time a good muscular curve and a low tonus at rest) and the underlying fatty convexities. As far as medicine is concerned, the combination of botulinum toxin and filling has proved its worth. But two technical elements are new: the filling products must, at several points, be injected primarily behind the muscle to treat the depressions naturally and restore the initial curve of the overlying muscle. A very low number of units (a quarter to one unit) of botulinum toxin must be injected into certain muscles to diminish the tonus at rest of these muscles without diminishing their strength in maximum contraction. In surgery, new possibilities to treat premature ageing include procedures that combine segmentary muscular weakening, micro liposuctions and retromuscular reinjections. The advantage with regard to the medical procedures is greater stability over time and the greater precision of these muscular actions (one third of a muscle can be weakened for example) and the fat reinjections can be more stable. These procedures can be performed under local anesthesia. In cases of more advanced ageing, surgery offers new treatment possibilities that include, for the midface region, the concentric malar lift. It replaces, on the orbital rim, the sub-orbicularis oculi fat that has descended eccentrically as a result of the contractions of the orbicularis oculi muscle. The procedure, using the subperiosteal detachment plane, is therefore stable over time. At the same time, specific muscles are weakened. The aims of restoring fatty volumes and muscular tonuses are thus achieved. Similarly, in the neck, the platysma muscle is specifically weakened. Each area is studied in line with its specificities. For the first time, the skin tension of the facelift has no more to be maximum to treat the relief of the jawl line, of the palpebro malar groove and so on. The skin tension becomes moderate, just to remove the excess of skin. The relief is faded with the specific muscular and fatty action. The name of this new concept is Face Recurve.

Turning Back Time : Rheological and Microstructural Assessment of Rejuvenated Bitumen

NARCIS (Netherlands)

Nahar, S.N.; Schmets, A.J.M.; Schlangen, E.; Shirazi, M.; van de Ven, M.F.C.; Schitter, G.; Scarpas, A.

2014-01-01

Countermeasures to the ageing of bituminous asphalt binders is a highly important topic, both for service-life extension of asphalt ‘in the field’ and for recycling old pavements (RAP) into new structures with similar functional requirements as the original structure. Usually this is achieved by

Supra-chondritic Nb/Ta ratios and other exotic geochemical signatures in rejuvinated Hawaiian magmas as fingerprints of carbonatitic auto-metasomatism in parts of the Hawaiian mantle plume

OpenAIRE

A. Rocholl; K. P. Jochum; D. Rhede; B. Stoll; U. Weis

2014-01-01

The rejuvenated Honolulu Volcanics (HV), Oahu, Hawaii, comprise small-volume magmas ranging from alkali basalt through basanite and nephelinite to melilite. Their origin is enigmatic and debated, because the magmas are highly enriched in incompatible trace elements but isotopically depleted and erupted some 1.3 Myrs after the Koolau shield building phase had ceased. We have analysed 26 HV basanitic to melilitic tuffs from Salt Lake Crater at Honolu...

Computational fluid dynamics modelling of displacement natural ventilation.

OpenAIRE

Ji, Yingchun

2005-01-01

Natural ventilation is widely recognised as contributing towards low-energy building design. The requirement to reduce energy usage in new buildings has rejuvenated interest in natural ventilation. This thesis deals with computer modelling of natural displacement ventilation driven either by buoyancy or buoyancy combined with wind forces. Two benchmarks have been developed using computational fluid dynamics (CFD) in order to evaluate the accuracy with which CFD is able to mo...

Organizing for Innovation in a Shared Services Organization: A Case Study of Ericsson

OpenAIRE

Tsagkari, Kleopatra-Zoi

2016-01-01

Intense global competition and rapid technological advances have seen innovation become central towards enabling firms to adapt and rejuvenate themselves. While firms become increasingly focused on innovation, the challenge of managing innovation and developing innovation capabilities still remains. The purpose of this thesis is to analyse and evaluate the innovation capabilities of Ericsson’s Shared Services Organization (SSO). To do so, the existing literature and theories are synthesized a...

An ingredient for the elixir of youth.

Science.gov (United States)

Andersen, Rebecca E; Lim, Daniel A

2014-12-01

Emerging evidence indicates that there are factors within the blood of young animals that have the ability to restore youthful characteristics to a number of organ systems in older animals. Growth/differentiation factor 11 (GDF11) is the first of such factors to be identified, and two new studies demonstrate that this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.

An imperfect reality: gender mainstreaming and disarmament, demobilisation, rehabilitation and reintegration (DDRR) in Liberia

OpenAIRE

Basini, Helen. S.A

2013-01-01

peer-reviewed Disarmament, Demobilisation and Reintegration (DDR) programmes are a fundamental component in peacebulding operations and feature in most contemporary peace agreements. Since the conceptualisation of peacebuilding in the early 1990s, there has been a marked shift towards promoting the spread of liberal democracy, rule of law and rejuvenation of markets in countries emerging from conflict. This liberal peacebuilding approach has been criticised by scholars for c...

Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application

OpenAIRE

Zhao, Pan; Sui, Bing‐Dong; Liu, Nu; Lv, Ya‐Jie; Zheng, Chen‐Xi; Lu, Yong‐Bo; Huang, Wen‐Tao; Zhou, Cui‐Hong; Chen, Ji; Pang, Dan‐Lin; Fei, Dong‐Dong; Xuan, Kun; Hu, Cheng‐Hu; Jin, Yan

2017-01-01

Summary Cutaneous wounds are among the most common soft tissue injuries and are particularly hard to heal in aging. Caloric restriction (CR) is well documented to extend longevity; pharmacologically, profound rejuvenative effects of CR mimetics have been uncovered, especially metformin (MET), resveratrol (RSV), and rapamycin (RAPA). However, locally applied impacts and functional differences of these agents on wound healing remain to be established. Here, we discovered that chronic topical ad...

Applications of quaternary stratigraphic, soil-geomorphic, and quantitative geomorphic analyses to the evaluation of tectonic activity and landscape evolution in the Upper Coastal Plain, South Carolina

International Nuclear Information System (INIS)

Hanson, K.L.; Bullard, T.F.; Wit, M.W. de; Stieve, A.L.

1993-01-01

Geomorphic analyses combined with mapping of fluvial terraces and upland geomorphic surfaces provide new approaches and data for evaluating the Quaternary activity of post-Cretaceous faults that are recognized in subsurface data at the Savannah River Site in the Upper Coastal Plain of southwestern South Carolina. Analyses of longitudinal stream and terrace profiles, regional slope maps, and drainage basin morphometry indicate long-term uplift and southeast tilt of the site region. Preliminary results of drainage basin characterization suggests an apparent rejuvenation of drainages along the trace of the Pen Branch fault (a Tertiary reactivated reverse fault that initiated as a basin-margin normal fault along the northern boundary of the Triassic Dunbarton Basin). This apparent rejuvenation of drainages may be the result of nontectonic geomorphic processes or local tectonic uplift and tilting within a framework of regional uplift. Longitudinal profiles of fluvial terrace surfaces that are laterally continuous across the projected surface trace of the Pen Branch fault show no obvious evidence of warping or faulting within a resolution of ∼3 m. This combined with the estimated age of the terrace surfaces (350 ka to 1 Ma) indicates that if the Pen Branch fault is active, the Pleistocene rate of slip is very low (0.002 to 0.009 mm/yr)

Cosmetic mesotherapy: between scientific evidence, science fiction, and lucrative business.

Science.gov (United States)

Atiyeh, Bishara S; Ibrahim, Amir E; Dibo, Saad A

2008-11-01

Mesotherapy, originally conceived in Europe, is a minimally invasive technique that consists of the intra- or subcutaneous injection of variable mixtures of natural plant extracts, homeopathic agents, pharmaceuticals, vitamins, and other bioactive substances in microscopic quantities through dermal multipunctures. Its application in cosmetic medicine and surgery is gaining in popularity and acceptance and is rapidly growing in profile at an alarming rate. Despite their attraction as purported rejuvenating and ''fat-dissolving'' injections, the safety and efficacy of these novel cosmetic treatments remain ambiguous, making mesotherapy vulnerable to criticism by the generally more skeptical medical community. The technique is shrouded in mystery and the controversy surrounding it pertains to its efficacy and potential adverse effects that are subject of much concern. As with any new technology, it is important to assess the benefits, safety, experience, and standardization of mesotherapy. More studies are necessary before it can be advocated as a safe and effective treatment for body contouring and facial rejuvenation. Although the claims made about mesotherapy may be hard to believe at face value, we must be cautious about rejecting new ideas. Just as absence of proof is not proof of absence, lack of scientific validation is not proof that it does not work.

Zircon reveals protracted magma storage and recycling beneath Mount St. Helens

Science.gov (United States)

Claiborne, L.L.; Miller, C.F.; Flanagan, D.M.; Clynne, M.A.; Wooden, J.L.

2010-01-01

Current data and models for Mount St. Helens volcano (Washington, United States) suggest relatively rapid transport from magma genesis to eruption, with no evidence for protracted storage or recycling of magmas. However, we show here that complex zircon age populations extending back hundreds of thousands of years from eruption age indicate that magmas regularly stall in the crust, cool and crystallize beneath the volcano, and are then rejuvenated and incorporated by hotter, young magmas on their way to the surface. Estimated dissolution times suggest that entrained zircon generally resided in rejuvenating magmas for no more than about a century. Zircon elemental compositions reflect the increasing influence of mafic input into the system through time, recording growth from hotter, less evolved magmas tens of thousands of years prior to the appearance of mafic magmas at the surface, or changes in whole-rock geochemistry and petrology, and providing a new, time-correlated record of this evolution independent of the eruption history. Zircon data thus reveal the history of the hidden, long-lived intrusive portion of the Mount St. Helens system, where melt and crystals are stored for as long as hundreds of thousands of years and interact with fresh influxes of magmas that traverse the intrusive reservoir before erupting. ?? 2010 Geological Society of America.

The 'Nefertiti lift': a new technique for specific re-contouring of the jawline.

Science.gov (United States)

Levy, Phillip M

2007-12-01

Botulinum toxin type A (BoNTA) is now used extensively for rejuvenation of the forehead, glabellar and periocular regions and there is increasing focus on treatment of the lower face. Although there is well-documented evidence for the efficacy of botulinum toxin in the correction of platysmal bands, little work has been done to explore its potential role in rejuvenation of the jawline. To date, effects in this area have been reported as a consequence of platysmal banding treatment and are inconsistent. Hesitancy to explore treatment may be due to evidence of a greater, more durable response to the toxin in the lower facial muscles as well as reports of increased potential migration and subsequent side effects. This paper describes a new technique using BoNTA (Vistabel); Allergan, Irvine, CA, USA) to drape the skin of the jawline contour and provide the visual effect of a 'mini lift'. Experience with 130 patients with doses of BoNTA up to 20 U is described. Patient satisfaction is extremely high and the specificity of dosing and technique has led to a low incidence of adverse effects. The 'Nefertiti lift' is a minimally invasive, effective and acceptable alternative for those patients seeking an effective way to push back surgery.

Purse-string platysmaplasty: the third dimension for neck contouring.

Science.gov (United States)

Gentile, Richard D

2005-11-01

Techniques and concepts for treatment of the aging neck have been evolving since the late 1960s and rely on two-dimensional anterior approximation with lateral imbrication of the platysma with or without submental fat reduction, However, the medial approximation can sometimes give a "boxy" appearance to the anterior neck, especially if anterior shifting of the platysma recurs after platysmaplasty with laxity redeveloping in this midline location. The "purse-string" platysmaplasty (PSP) is a new concept in neck contouring that facilitates an enhanced definition for the cervicomandibular transition to better simulate the well-defined contour of this transition that is present in youth. It aids in the contouring of difficult poorly defined necks and in male patients. The PSP adds a "third dimension" to neck recontouring by invaginating the platysma with a plication suture and pexing the platysma, without incising it, to deeper neck fascia with a technique that adds support and definition to the neck contour. The PSP can be performed in patients undergoing a full rhytidectomy as well as in individuals having isolated neck rejuvenation. The PSP is especially helpful in rejuvenating the male lower face and neck because of the relatively heavier deeper structures of the male neck and the need to enhance definition along the jawline.

A novel specialized suture and inserting device for the resuspension of ptotic facial tissues: early results.

Science.gov (United States)

Bisaccia, Emil; Kadry, Razan; Saap, Liliana; Rogachefsky, Arlene; Scarborough, Dwight

2009-04-01

In the past decade, the popularity of minimally invasive procedures for facial rejuvenation has increased. To describe a new specialized suture, and its associated technique, used to elevate sagging tissues of the face and neck. A detailed description of the technique and the results obtained in 20 patients in whom we have used this novel approach. Attention was given to appropriate patient selection. The primary focus was on the correction of the jowl, jawline, and neck subunits. It involves the percutaneous introduction of a novel 3-0 polypropylene suture that has 10 absorbable hollow cones along its axis that are equally interspersed with knots. Once the absorbable cones are resorbed into the surrounding tissues, the non-absorbable suture component can be removed without compromising the aesthetic outcome. All patients demonstrated improvement in these areas, with minimal complications. One patient required resuspension using the open technique. (Excessive ptotic tissue was later excised for an optimal cosmetic result.) The suture and technique described in this article provide a major contribution to the correction of ptosis of facial tissues. When done in conjunction with other procedures, such as neck and jowl microliposuction, this technique has proven to be a useful addition to facial rejuvenation.

Use of a controlled subdermal radio frequency thermistor for treating the aging neck: Consensus recommendations.

Science.gov (United States)

Kinney, Brian M; Andriessen, Anneke; DiBernardo, Barry E; Bloom, Jason; Branson, Dennis F; Gentile, Richard D; Goldberg, David J; Lorenc, Paul Z; Nestor, Mark; Wu, Douglas

2017-12-01

A new temperature-controlled device has been used as a percutaneous radio frequency probe to treat lax submental and other facial areas. It has significant advantages over other esthetic devices as it provides the dual benefit of fat lipolysis and skin tightening. Our goal here is to present consensus recommendations for treating the aging neck. A panel of 11 expert physicians convened in Dallas, Texas, on October 15, 2016 to arrive at a consensus on the best current practice for submental skin tightening and contour improvement. Prior to the meeting, a comprehensive review of the literature was performed and a survey was sent to esthetic dermatologists and plastic surgeons who were queried about various aspects of neck rejuvenation. The literature search revealed 10 different technologies for neck rejuvenation evaluated in double-blind (n = 2) and single-blind (n = 1) clinical trials and other clinical evaluations (n = 21). The survey was sent via an email to 1248 individuals and was completed by 92 respondents. Review of the data and discussion by meeting attendees generated eight consensus recommendations. Subdermal monopolar radio frequency represents an effective means for disrupting fat volume and skin tightening of the face, neck, and jawline. For suitable patients, this treatment can be used to achieve significant esthetic improvements.

A 12-week clinical and instrumental study evaluating the efficacy of a multisource radiofrequency home-use device for wrinkle reduction and improvement in skin tone, skin elasticity, and dermal collagen content.

Science.gov (United States)

Sadick, Neil S; Harth, Yoram

2016-12-01

This study was performed in order to evaluate the safety and efficacy of a new handheld home-use multisource radiofrequency device on facial rejuvenation. Forty-seven male and female subjects were enrolled. All subjects received a NEWA ® 3DEEP ™ home-use device (EndyMed Medical, Caesarea, Israel) to be used on facial skin three times per week for the first four weeks and then reduced to two times per week for the following eight weeks. Assessments included expert clinical grading for efficacy, instrumental evaluation, image analysis, and photography. Forty-five subjects completed the study; all subjects reported the treatment to be painless with only mild erythema lasting up to 15 minutes post-treatment. No other adverse events were reported. Statistically significant improvements were noted in the appearance of marionette lines, skin brightness, elasticity, firmness, lift (facial), lift (jawline), texture/smoothness, tone, and radiance/luminosity by expert visual assessment. Statistically significant improvements in skin firmness and elasticity were found using a Cutometer MPA 580, as well as in collagen and hemoglobin content of the skin using a SIAscope. The results of this study indicate that the NEWA ® multisource radiofrequency home-use device is effective in self-administered skin rejuvenation.

Estágios do ciclo de vida e perfil de empresas familiares brasileiras

Directory of Open Access Journals (Sweden)

Fábio Frezatti

2017-12-01

Full Text Available The distinctive features of family firms, such as family influence, add complexity to organizational life-cycle models in terms of the different stages of development. This research analyzes the relationship between stages of the organizational life cycle proposed by Lester et al. (2003 and the elements of influence of the F-PEC family (power, experience, and culture. The study was developed through a sample of 117 Brazilian family companies, without the participation of companies with shares traded on the stock exchange, and employed statistical treatment of the data through a structural equation model. As a result, the elements of F-PEC were partially identified in the sample. Power indicates the control of the company by the family, experience indicates the role of the different generations, and culture indicates the values of the controllers. In particular, it should be pointed out that, at birth, power and culture play important roles; in maturity, experience and culture stand out, and in rejuvenation, power and culture have been identified as characteristic. As an exploratory analysis, the article contributes to the understanding of organizations, by indicating the development of comparative analyses and performance on the variables that provide migration planning to more desirable stages, such as growth, maturity, and rejuvenation.

Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain

Directory of Open Access Journals (Sweden)

Sanberg Paul R

2008-02-01

Full Text Available Abstract Background Neurogenesis continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammation. Results We determined that human umbilical cord blood mononuclear cells (UCBMC given peripherally, by an intravenous injection, could rejuvenate the proliferative activity of the aged neural stem/progenitor cells. This increase in proliferation lasted for at least 15 days after the delivery of the UCBMC. Along with the increase in proliferation following UCBMC treatment, an increase in neurogenesis was also found in the aged animals. The increase in neurogenesis as a result of UCBMC treatment seemed to be due to a decrease in inflammation, as a decrease in the number of activated microglia was found and this decrease correlated with the increase in neurogenesis. Conclusion The results demonstrate that a single intravenous injection of UCBMC in aged rats can significantly improve the microenvironment of the aged hippocampus and rejuvenate the aged neural stem/progenitor cells. Our results raise the possibility of a peripherally administered cell therapy as an effective approach to improve the microenvironment of the aged brain.

Relation between the organizational lifecycle and planning: a study of accounting service companies from the state of Santa Catarina

Directory of Open Access Journals (Sweden)

Dinorá Baldo de Faveri

2014-11-01

Full Text Available The study aims to identify the relation between the different stages of the organizational lifecycle and the planning process of accounting service companies in the State of Santa Catarina. This descriptive research with a quantitative approach was undertaken through a survey in a convenience sample of 116 companies. Therefore, the model by Miller and Friesen (1984 was used to identify the lifecycle stages and the instrument by Frezatti, Relvas, Nascimento, Junqueira and Souza (2010 to measure the usage level of the planning artifacts. The planning was analyzed in its three modalities: Strategic Planning, Budget and Budgetary Control. To analyze the data, discriminant and correlation analyses were used. The study results showed that the accounting service companies are classified in distinct stages of the organizational lifecycle, predominantly birth and rejuvenation. Only half of the companies analyzed use the budget, even when managed by people with a background in the area who know the importance of this instrument. In addition, a negative correlation was observed between the stages of birth and decline and the use of the planning artifacts and a positive correlation between the stages of growth, maturity and rejuvenation, in line with the results by Miller and Friesen (1984.

Has the Effect of Mesotherapy Been Proved?

OpenAIRE

Gonca Gökdemir

2009-01-01

Mesotherapy is a medical technique that consist of the intracutaneous or subcutaneous injection to the diseased area. It has become as a populer treatment method in cosmetic dermatology recently. Mesotherapy has been used in the treatment of skin rejuvenation, cellulite and localized fat reduction. Substances using in mesotherapy are plant extracts, homeopathic agents, vitamins, and some pharmaceuticals. The effect of these agents are not completely known. There are few experimental and clini...

Aging and neoteny in the B lineage

OpenAIRE

Melamed, Doron; Scott, David W.

2012-01-01

Aging and the physiologic decline of tissues and cells were once thought to be irreversible. However, recent studies suggest that various tissues, especially parts of the hematopoietic system, can be rejuvenated. Here we review potential mechanisms for this process and how they may be used to reverse age-related disorders and aging in general. We propose the novel hypothesis that altering the homeostatic process during cellular depletion can reverse aging in the hematopoietic system.

Uranium deposits of the Asian sector of Pacific ocean ore belt

International Nuclear Information System (INIS)

Kazanskij, V.I.

1995-01-01

Brief description of three basic types of uranium ore deposits in the Asian sector of the Pacific Ocean ore belt, namely uranium-molybdenum vein deposits in the continental volcanic depressions, proper uranium-molybdenum vein deposits in the mesozoic granites and gold-brannerite deposits of the rejuvenated early-proterosoic fractures is given. Schemes of various deposits are presented, petrological and isotope data (K-Ar method) are considered and petro- and oregenesis are analyzed. refs., 9 figs

Laser Resurfacing

OpenAIRE

Janik, Joseph P.; Markus, Jodi L.; Al-Dujaili, Zeena; Markus, Ramsey F.

2007-01-01

In a society desiring images of beauty and youthfulness, the world of cutaneous surgery offers the gifts of facial rejuvenation for those determined to combat the signs of aging. With the development of novel laser and plasma technology, pigmentary changes, scarring, and wrinkles can be conquered providing smoother, healthier, younger-looking skin. This review highlights five of the most popular resurfacing technologies in practice today including the carbon dioxide (CO2) laser, the erbium:yt...

ONLINE BANKING IN THE ROMANIAN BANKING SYSTEM

OpenAIRE

IMOLA DRIGĂ

2014-01-01

In the world of banking, the development of IT has a huge effect on development of more flexible payments methods and more user-friendly banking services. Recently, modern electronic banking services, internet and mobile banking, have rejuvenated banking transactions. Electronic banking over the Internet is one of the newest e-banking services with several benefits both for banks and for customers. The paper aims to provide an overview of online banking services highlighting various aspect...

Mythology and evidence-based oncology: An indivisible link.

Science.gov (United States)

Rathod, Shrinivas; Agarwal, Jai Prakash; Munshi, Anusheel

2016-01-01

Religion has an important role in the birth of medicine and shares a long history. Contradiction has separated spirituality and medicine. For so many years, the spiritual dimension of medicine was seen as unnecessary and inappropriate. However times are changing again and since the last few decades, recent literature and various ongoing studies have focused on unmet spiritual needs of physician and patient. This article focuses on the rejuvenating link between medicine and spirituality.

Anatomy of ageing face.

Science.gov (United States)

Ilankovan, V

2014-03-01

Ageing is a biological process that results from changes at a cellular level, particularly modification of mRNA. The face is affected by the same physiological process and results in skeletal, muscular, and cutaneous ageing; ligamentous attenuation, descent of fat, and ageing of the appendages. I describe these changes on a structural and clinical basis and summarise possible solutions for a rejuvenation surgeon. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

Bridging traits, story, and self: Prospects and problems

OpenAIRE

Hermans, H.J.M.

1996-01-01

In his target article, McAdams brings together three domains in the field of psychology in which challenging developments have been observed over the past decades: trait psychology, narrative psychology, and culture. Trait psychology has been rejuvenated by crossnational and cross-cultural research projects on the "Big Five". The narrative approach has cropped up in a great diversity of psychological subdisciplines, including personality psychology, and is on its way to being accepted as a re...

Canadian Library Human Resources Short‐Term Supply and Demand Crisis Is Averted, But a Significant Long‐Term Crisis Must Be Addressed. A review of: 8Rs Research Team. The Future of Human Resources in Canadian Libraries February 2005. Edmonton, AB: University of Alberta. 21 February 2007 .

OpenAIRE

Julie McKenna

2007-01-01

Objective – To examine the human resources environment in Canadian libraries in order to assess readiness to accommodate change and to identify opportunities for human resources planning. The “8Rs” of the study were defined as recruitment, retirement, retention, remuneration, repatriation, rejuvenation, re‐accreditation, and restructuring.Design – This study was undertaken in three phases over nearly three years through the use a variety of methods including literature review, analyses of exi...

The Dragon’s Rise: A Historical Analysis of China’s Bilateral Diplomacy

Science.gov (United States)

2015-09-01

legitimacy could, and likely would in their minds, be challenged thereby preventing the glorious rejuvenation of China. Mao and his fellow party...credence to Mao’s view that the Americans were trying to encircle the PRC by forming alliances from French -Indo China to Korea and that any hope the...age old fascination with the West manifested itself with the arrival of American fast food chains and the desire for a more democratic style of

VOLUNTARY SURGICAL CONTRACEPTION OF WOMEN OF LATE REPRODUCTIVE AGE SUFFERING FROM PELVIC ORGAN PROLAPSE – FEATURES AND BENEFITS

OpenAIRE

Nigina Nasimova

2015-01-01

In recent years there has been a noticeable "rejuvenation" of pelvic organ prolapse. Inconsistency of the pelvic floor muscles, including the omission of sexual organs, is extremely common pathology, observed almost a third of women of reproductive age. The search for effective, convenient methods of contraception for this category of patients is an important problem of modern gynecology.We proposed a method of transvaginal voluntary surgical contraception, produced in conjunction with surgic...

Warner Bros. and Its First Two Great Depression Musicals:Changing the Form and Reflecting the Times

OpenAIRE

Cohen, Harvey

2013-01-01

This working paper analyses the production, content, public reaction and significance of the first two Warner Bros. Great Depression Musicals (this term was created by later scholars). "42nd Street" and "Gold Diggers of 1933," both released in the first half of 1933 during some of the direst months of the Great Depression, artistically and financially rejuvenated the previously failing genre of the film musical. They both featured extravagant highly cinematic dance numbers created by Busby Be...

A case of mesotherapy-induced panniculitis.

Science.gov (United States)

Polat, Muhterem; Üstün, Hüseyin

2016-01-01

Mesotherapy was first introduced in Europe for the treatment of localized pain. It is currently used mainly for aesthetical purposes and gradually getting widely used for body contouring, cellulite reduction, and skin rejuvenation. The reports concerning about mesotherapy is increasing in number in the literature. There are reported systemic and local side effects of mesotherapy. Panniculitis is a rare side effect of mesotherapy. In this article, we report a case of mesotherapy-induced panniculitis who responded to dapsone therapy.

Heartbreak hotel: a convergence in cardiac regeneration.

Science.gov (United States)

Schneider, Michael D

2016-05-01

In February 2016, The Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on 'Transdifferentiation and Tissue Plasticity in Cardiovascular Rejuvenation'. As I review here, participants at the workshop revealed how understanding cardiac growth and lineage decisions at their most fundamental level has transformed the strategies in hand that presently energize the prospects for human heart repair. © 2016. Published by The Company of Biologists Ltd.

Skin resurfacing procedures: new and emerging options

OpenAIRE

Loesch MM; Somani AK; Kingsley MM; Travers JB; Spandau DF

2014-01-01

Mathew M Loesch,1 Ally-Khan Somani,1 Melanie M Kingsley,1 Jeffrey B Travers,1–3 Dan F Spandau1,41Department of Dermatology, 2Department of Pharmacology and Toxicology, 3Department of Pediatrics, 4Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USAAbstract: The demand for skin resurfacing and rejuvenating procedures has progressively increased in the last decade and has sparked several advances within the skin resurfacing fie...

Systems immunology: just getting started

OpenAIRE

Davis, Mark M; Tato, Cristina M; Furman, David

2017-01-01

Systems-biology approaches in immunology take various forms, but here we review strategies for measuring a broad swath of immunological functions as a means of discovering previously unknown relationships and phenomena and as a powerful way of understanding the immune system as a whole. This approach has rejuvenated the field of vaccine development and has fostered hope that new ways will be found to combat infectious diseases that have proven refractory to classical approaches. Systems immun...

The research of enterprise innovation

Institute of Scientific and Technical Information of China (English)

2011-01-01

Small and medium-sized enterprises are power based which can promote the development of national economy, construction market economic system, promote social stability.Especially at the moment, in ensure moderate growth of the national economy, relieve employment pressure, realize rejuvenating the country through science and education, optimize economic structure, the small and medium-sized enterprises are playing more and more important role. The lack of innovative capacity of SMEs in China, has seriously af- fected the development of SMEs.

Long-Term Performance Evaluation of Asphalt Surface Treatments: Product Placement

Science.gov (United States)

2010-02-01

spreader . The aggregate was applied to increase the friction of the treated area. A Ford F550 truck was used to seat the aggregate by traversing the...area is sealed, and the steel media are vacuumed back through the shot blaster to be recycled and cleaned for repetitive use. Once the process is...applying the rejuvenator, approximately 0.7 lb/yd2 of Black Beauty aggregate was spread over the section using a garden fertilizer spreader . The

Analysis of the efficacy of marketing tools in facial plastic surgery.

Science.gov (United States)

Zavod, Matthew B; Adamson, Peter A

2008-06-01

To compare referral sources to a facial plastic surgery practice and to develop models correlating the referral source with the decision for surgery. Retrospective descriptive study. Well-established, metropolitan, private facial plastic surgery practice with training fellowship affiliated with an academic centre. One-thousand eighty-nine new consecutive patients presenting between January 2001 and December 2005 recorded intake data including age, gender, and chief complaint. Final data input was their decision for or against surgery. Main outcome measures included differences in referral sources based on data collected and how those sources related to decision for surgery. A 50% conversion rate was found. Women and older patients were more likely to be referred from magazines, television, and newspapers and for facial rejuvenation. Men and younger patients were more likely to be referred from the website and for rhinoplasty. For facial rejuvenation, both the number of patients interested in and the probability that they agreed to the procedure increased with age. For rhinoplasty, the converse was true. The most likely patients to schedule surgery were those who were referred from other patients, friends, or family members in our practice. The data confirm that word-of-mouth referrals are the most important source for predicting which patients will elect to proceed with surgery in this established facial cosmetic surgery practice.

Guest Editorial: Sabbaticals

Directory of Open Access Journals (Sweden)

Heather Kanuka

2007-11-01

Full Text Available It has been my pleasure to be the acting editor of IRRODL while Dr. Terry Anderson has been on sabbatical leave. While the value and need for academic sabbaticals has been passionately debated for decades (and will likely continue to be debated for decades to come, within the academy most, if not all, academics understand both the value and need for a career pause.An academic sabbatical is a prolonged leave, typically for one year after six years of continuous employment. Harvard University was the first to grant academics a sabbatical in 1880. The primary purpose was, and still is, to provide an opportunity for academics to fulfill a career goal (i.e., write a book, travel for research or an opportunity for collegial inter-visitations. The word ‘sabbatical’ has biblical origins connected to the practice of leaving land unplanted as a means of rejuvenation. The word originates from the Mosaic law of ancient Judea, during which farmers left land fallow for a year after six consecutive harvests. The spirit of rejuvenation and harvesting has remained unchanged within the academy. Similar to ‘leaving the land unplanted,’ academics ‘leave the daily demands of university life’ (e.g., teaching and service commitments for an opportunity to regenerate new ideas and pursue professional growth.

Specificity of facelift surgery, including mid facelift, in case of facial palsy.

Science.gov (United States)

Le Louarn, C

2015-10-01

The asymmetry created by the facial palsy is of course a cause of demand for facelift surgery. As this lifting action is specific and different from the standard procedures, 3 zones of analysis are proposed: first the frontal and temporal areas with the direct eyebrow lift, second the neck and jawline with action on the depressor anguli oris for the non-paralyzed side and the anterior sub SMAS dissection and third the midface. A new and more simple technique of concentric malar lift is proposed. The first publication on concentric malar lift was made 11years ago. Midface rejuvenation stays very challenging. As a proof of that, many authors prefer a partial rejuvenation of mid face with fat reinjection, with no effect on skin excess, even if all the MRI studies demonstrated no fat loss with time but only fat transfer. This proves that midface lift did not acquire enough simplicity, reliability to become a standard procedure. Six hundred concentric malar lift later, a technical simplification validated with 110 patients and 2years of follow-up is proposed. The improvement is due to a new way to pass the threads deeply on the bone, using permanent barbed sutures. This surgery becomes easier and more efficient. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

The anatomy of the aging face: volume loss and changes in 3-dimensional topography.

Science.gov (United States)

Coleman, Sydney R; Grover, Rajiv

2006-01-01

Facial aging reflects the dynamic, cumulative effects of time on the skin, soft tissues, and deep structural components of the face, and is a complex synergy of skin textural changes and loss of facial volume. Many of the facial manifestations of aging reflect the combined effects of gravity, progressive bone resorption, decreased tissue elasticity, and redistribution of subcutaneous fullness. A convenient method for assessing the morphological effects of aging is to divide the face into the upper third (forehead and brows), middle third (midface and nose), and lower third (chin, jawline, and neck). The midface is an important factor in facial aesthetics because perceptions of facial attractiveness are largely founded on the synergy of the eyes, nose, lips, and cheek bones (central facial triangle). For aesthetic purposes, this area should be considered from a 3-dimensional rather than a 2-dimensional perspective, and restoration of a youthful 3-dimensional facial topography should be regarded as the primary goal in facial rejuvenation. Recent years have seen a significant increase in the number of nonsurgical procedures performed for facial rejuvenation. Patients seeking alternatives to surgical procedures include those who require restoration of lost facial volume, those who wish to enhance normal facial features, and those who want to correct facial asymmetry. Important factors in selecting a nonsurgical treatment option include the advantages of an immediate cosmetic result and a short recovery time.

Restoring jawline contour with calcium hydroxylapatite: A prospective, observational study.

Science.gov (United States)

Baspeyras, Martine; Dallara, Jean-Marie; Cartier, Hugues; Charavel, Marie-Hélène; Dumas, Laurent

2017-09-01

Jawline reshaping by replacing volume has become an indispensable component of modern facial rejuvenation. To evaluate calcium hydroxylapatite (CaHA) for the treatment of an aging jawline in a routine setting. Five investigators enrolled 35 subjects requesting jawline rejuvenation with CaHA. Injections were performed according to investigators usual practice. Baseline and post-treatment scores were evaluated using Merz Aesthetics Scales®. Follow-up visits took place at Day 30 (Day 60 for those with touch-up at Day 30), 180, and 360. Physician and patient satisfaction, esthetic impact of treatment, and adverse events were recorded. Improvements in jawline contour compared with baseline were statistically significant at each visit, with scores of 2.42 (moderate to severe sagging) at baseline, 1.02 (mild) at Day 30/60 (P≤.0001), 1.11 at Day 180 (P≤.0001), and 1.45 at Day 360 (P=.0015). Statistically significant improvements in marionette line scores were also observed. Investigators rated results as "improved" to "very much improved" in all subjects up to Day 180, and in 81% of subjects at Day 360. Satisfaction with treatment was very high. Adverse events were mostly mild and related to either the procedure or injection technique. CaHA is a very effective agent for restoring jawline contour in routine practice and is associated with high levels of physician and patient satisfaction. © 2017 Wiley Periodicals, Inc.

Relative age and age sequence of fractions of soil organic matter

International Nuclear Information System (INIS)

Scharpenseel, H.W.

1975-01-01

Natural radiocarbon measurements on soil fractions provide information regarding the chances of separating the ''old biologically inert carbon'' out of samples of recent soil material. Beyond this, the relative fraction ages are scrutinized for the sequential order of the origin of the fractions within the biosynthetic reaction chain of soil humic matter. Among all fractions compared (classic humic matter fractionation by alkali and acid treatment; successive extraction with organic solvents of increasing polarity; separation according to particle size by Sephadex gel filtration; hydrolysis residue) the 6 n HCl hydrolysis residue shows the most consistent significant age increment. Repeated exhaustive hydrolysis treatment of the same sample material is still pending. All other fraction types indicate an age pattern under strong predetermination by method of origin, e.g., existence or lack of hydromorphy, without an evident enrichment of the ''old biologically inert carbon''. Among the organic extracts, no persistent age hierarchy is noticeable, whereas the classical fractions follow an age sequence mainly parallel to an increase of the molecular weight. Hymatomelanic acids appear rejuvenated by relics of recent carbon derived from the extractant ethanol. Grey humic acids are older than the brown humic acids, humines from fully terrestrial soil environment are older than humic acids, while in hydromorphic soils, cold alkali insoluble young C-compounds seem to be conserved which are liable to falsify rejuvenation of the humines

Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles.

Science.gov (United States)

Elnehrawy, Naema Y; Ibrahim, Zeinab A; Eltoukhy, Azza M; Nagy, Hala M

2017-03-01

Platelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers. PRP injection treatment provides supraphysiological concentrations of growth factors that may help in accelerated tissue remodeling and regeneration. To evaluate the efficacy and safety of single autologous PRP intradermal injection for treatment of facial wrinkles and for facial rejuvenation. A total of 20 subjects with different types of facial wrinkles were included in this study. All subjects received single PRP intradermal injection and were clinically assessed before and after treatment for a period of 8 weeks using Wrinkle Severity Rating Scale (WSRS), Skin Homogeneity and Texture (SHnT) Scale, Physician Assessment Scale, and Subject Satisfaction Scale. The mean value of WSRS reduced from 2.90 ± 0.91 before treatment to 2.10 ± 0.79 after 8 weeks of treatment. The most significant results were with younger subjects that have mild and moderate wrinkles of the nasolabial folds (NLFs). Fourteen of seventeen subjects with NLFs showed more than 25% improvement in their appearance. Side effects of PRP treatment were minimal to mild and with excellent tolerability. Single PRP intradermal injection is well tolerated and capable of rejuvenating the face and producing a significant correction of wrinkles especially the NLFs. © 2016 Wiley Periodicals, Inc.

The Role of Building Learning Cities in the Rejuvenation of Africa

Science.gov (United States)

Biao, Idowu; Esaete, Josephine; Oonyu, Joseph

2013-01-01

Although Africa has been home to famous ancient cities in the past, its modern conurbation areas are poor living spaces characterised by squalor, poor planning and human misery. The authors of this paper argue that the learning city concept, still almost unknown in Africa, holds enormous potential for redressing the dysfunctional state of things…

Cell rejuvenation and social behaviors promoted by LPS exchange in myxobacteria.

Science.gov (United States)

Vassallo, Christopher; Pathak, Darshankumar T; Cao, Pengbo; Zuckerman, David M; Hoiczyk, Egbert; Wall, Daniel

2015-06-02

Bacterial cells in their native environments must cope with factors that compromise the integrity of the cell. The mechanisms of coping with damage in a social or multicellular context are poorly understood. Here we investigated how a model social bacterium, Myxococcus xanthus, approaches this problem. We focused on the social behavior of outer membrane exchange (OME), in which cells transiently fuse and exchange their outer membrane (OM) contents. This behavior requires TraA, a homophilic cell surface receptor that identifies kin based on similarities in a polymorphic region, and the TraB cohort protein. As observed by electron microscopy, TraAB overexpression catalyzed a prefusion OM junction between cells. We then showed that damage sustained by the OM of one population was repaired by OME with a healthy population. Specifically, LPS mutants that were defective in motility and sporulation were rescued by OME with healthy donors. In addition, a mutant with a conditional lethal mutation in lpxC, an essential gene required for lipid A biosynthesis, was rescued by Tra-dependent interactions with a healthy population. Furthermore, lpxC cells with damaged OMs, which were more susceptible to antibiotics, had resistance conferred to them by OME with healthy donors. We also show that OME has beneficial fitness consequences to all cells. Here, in merged populations of damaged and healthy cells, OME catalyzed a dilution of OM damage, increasing developmental sporulation outcomes of the combined population by allowing it to reach a threshold density. We propose that OME is a mechanism that myxobacteria use to overcome cell damage and to transition to a multicellular organism.

Transmutations: Rejuvenation, Longevity, and Immortality Practices in South and Inner Asia

Directory of Open Access Journals (Sweden)

Dagmar Wujastyk

2017-12-01

Full Text Available Wild and diverse outcomes are associated with transmutational practices: the prolongation of life, the recovery of youth, the cure of diseases, invincibility, immortality, enlightenment, liberation from the cycle of rebirths, and unending bliss. This range of outcomes is linked to specific practices taught in separate traditions and lineages in medical, alchemical, yogic and tantric milieus across South and Inner Asia. These practices can be individual or collective, esoteric or secular, and occur in different places from hospital to village to monastery; they involve transmutations of substances as well as transmutations of the body. Every expression by a particular lineage has a distinguishing articulation. Yet there are also very clear commonalities and interconnections between the traditions’ aims, methods and expected results. In this special issue of HSSA, we examine transmutational practices and their underlying concepts in this wider context of South and Inner Asian culture. How do these practices and ideas connect and cross-fertilise? And conversely, how are they delineated and distinct?

Investigating behavior changes of laying hens molted by high dietary zinc

OpenAIRE

Smayyeh Salari; Somayyeh Salari

2016-01-01

Introduction The commercial egg industry commonly uses induced molt procedures to rejuvenate flocks for a second or third laying cycle. Molting may be induced by feed withdrawal for up to 10 days (7), water withdrawal for 2 days (19), or both, along with a reduction of day length (14). Such programs cause concern about animal welfare because it is thought that they may be harmful to hens (28). Given the concerns for potential bird stress, various methods of nutrient restriction that would avo...

A phenomenological study of the therapeutic benefits of woodcarving

OpenAIRE

Hamilton, Graeme Muir

2015-01-01

The pace of life in modern society can be hectic and unrelenting. It is therefore not surprising that people often feel emotionally and physically depleted and seek out ways to relax and rejuvenate mentally, physically, emotionally, and spiritually. There are many forms of recreational and therapeutic activities that people engage in during their day to day lives in order to relax and recuperate from the grind of modern life. Some activities are physical in nature, such as yoga, baseball, j...

Detecting the changes in rural communities in Taiwan by applying multiphase segmentation on FORMOSA-2 satellite imagery

Science.gov (United States)

Huang, Yishuo

2015-09-01

Agricultural activities mainly occur in rural areas; recently, ecological conservation and biological diversity are being emphasized in rural communities to promote sustainable development for rural communities, especially for rural communities in Taiwan. Therefore, since 2005, many rural communities in Taiwan have compiled their own development strategies in order to create their own unique characteristics to attract people to visit and stay in rural communities. By implementing these strategies, young people can stay in their own rural communities and the rural communities are rejuvenated. However, some rural communities introduce artificial construction into the community such that the ecological and biological environments are significantly degraded. The strategies need to be efficiently monitored because up to 67 rural communities have proposed rejuvenation projects. In 2015, up to 440 rural communities were estimated to be involved in rural community rejuvenations. How to monitor the changes occurring in those rural communities participating in rural community rejuvenation such that ecological conservation and ecological diversity can be satisfied is an important issue in rural community management. Remote sensing provides an efficient and rapid method to achieve this issue. Segmentation plays a fundamental role in human perception. In this respect, segmentation can be used as the process of transforming the collection of pixels of an image into a group of regions or objects with meaning. This paper proposed an algorithm based on the multiphase approach to segment the normalized difference vegetation index, NDVI, of the rural communities into several sub-regions, and to have the NDVI distribution in each sub-region be homogeneous. Those regions whose values of NDVI are close will be merged into the same class. In doing so, a complex NDVI map can be simplified into two groups: the high and low values of NDVI. The class with low NDVI values corresponds to those

Du cycle orogénique hercynien au pré-rifting de l'Atlantique central au Maroc occidental : les microdiorites des Jbilet sont-elles des marqueurs magmatiques de ce passage ?From the Hercynian orogenic cycle towards the central Atlantic prerifting in central Morocco: are the Jbilet microdiorites possible magmatic markers for this transition?

Science.gov (United States)

Youbi, Nasrreddine; Bellon, Hervé; Marzin, Arnaud; Piqué, Alain; Cotten, Joseph; Cabanis, Bruno

2001-09-01

Microdioritic intrusives crosscut the Hercynian structures of the Jbilet massif in the western Morocco. Their mineralogical, petrological and geochemical compositions display the main characteristics of calc-alkaline magmas and any of the alkaline ones. This magmatic event occurred at ca 255 Ma, as indicated by the 40K- 40Ar age of fresh kaersutite crystals, but seven ages for whole-rock samples, scattered between 231 and 180 Ma, reflect the general rejuvenation of the ages linked to a latter penetrative alteration event of their feldspars and groundmass.

"Walk the Rim, Feel the Bone" Technique in Superior Sulcus Filling.

Science.gov (United States)

Looi, Audrey L G; Yong, Kai-Ling

2015-12-01

Superior sulcus filler injection is a nonsurgical method to rejuvenate the upper face. Blindness and stroke are devastating complications of facial filler injection. This study describes an injection technique that minimizes the risk of blindness and includes a case study demonstrating the cosmetic benefits of this procedure. To avoid retrograde injection of filler embolus into the ophthalmic artery, we advocate a "'walk the rim, feel the bone" approach. Small boluses of hyaluronic acid filler are given in preperiosteal plane, avoiding the superior orbital foramen.

Hypopigmentation Induced by Frequent Low-Fluence, Large-Spot-Size QS Nd:YAG Laser Treatments.

Science.gov (United States)

Wong, Yisheng; Lee, Siong See Joyce; Goh, Chee Leok

2015-12-01

The Q-switched 1064-nm neodymium-doped yttrium aluminum garnet (QS 1064-nm Nd:YAG) laser is increasingly used for nonablative skin rejuvenation or "laser toning" for melasma. Multiple and frequent low-fluence, large-spot-size treatments are used to achieve laser toning, and these treatments are associated with the development of macular hypopigmentation as a complication. We present a case series of three patients who developed guttate hypomelanotic macules on the face after receiving laser toning treatment with QS 1064-nm Nd:YAG.

Immobilization-associated osteoporosis in primates

Science.gov (United States)

Young, D. R.; Niklowitz, W. J.; Brown, R. J.; Jee, W. S. S.

1986-01-01

Osteopenic changes in the tibial compact bone of fifteen adult male monkeys immobilized for up to 7 months are examined histologically. Osteonal formation in the proximal tibia is analyzed. The analysis reveals the loss of haversian bone in the proximal tibia, increased activation with excessive depth of penetration of osteoclastic activity, rapid bone loss, and resorption cavities of irregular size and orientation. Osteonal formation following reambulation is examined; the recovery of cortical is a repair and rejuvenation process characterized by refilling of resorption cavities and remodeling activities.

Non-invasive bleaching of the human lens by femtosecond laser photolysis

DEFF Research Database (Denmark)

Kessel, L.; Eskildsen, Lars; Poel, Mike van der

2010-01-01

. Reducing blindness from cataract requires solutions that can be applied outside operating theatres. Cataract is a protein conformational disease characterized by accumulation of light absorbing, fluorescent and scattering protein aggregates. The aim of the study was to investigate whether these compounds...... by a non-invasive procedure based on femtosecond laser photolysis. Cataract is a disease associated with old age. At the current technological stage, lens aging is delayed but with a treatment covering the entire lens volume complete optical rejuvenation is expected. Thus, femtosecond photolysis has...

Genomic Physics. Multiple Laser Beam Treatment of Alzheimer's Disease

Science.gov (United States)

Stefan, V. Alexander

2014-03-01

The synapses affected by Alzheimer's disease can be rejuvenated by the multiple ultrashort wavelength laser beams.[2] The guiding lasers scan the whole area to detect the amyloid plaques based on the laser scattering technique. The scanning lasers pinpoint the areas with plaques and eliminate them. Laser interaction is highly efficient, because of the focusing capabilities and possibility for the identification of the damaging proteins by matching the protein oscillation eigen-frequency with laser frequency.[3] Supported by Nikola Tesla Labs, La Jolla, California, USA.

Revisiting reflexology: Concept, evidence, current practice, and practitioner training

OpenAIRE

Embong, Nurul Haswani; Soh, Yee Chang; Ming, Long Chiau; Wong, Tin Wui

2015-01-01

Reflexology is basically a study of how one part of the human body relates to another part of the body. Reflexology practitioners rely on the reflexes map of the feet and hands to all the internal organs and other human body parts. They believe that by applying the appropriate pressure and massage certain spots on the feet and hands, all other body parts could be energized and rejuvenated. This review aimed to revisit the concept of reflexology and examine its effectiveness, practices, and th...

Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering.

Science.gov (United States)

Elghblawi, Ebtisam

2017-09-08

The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage. Thus, youth is in your blood as it has a magical power imposed in the platelet factors. There is, however, no standardization of the techniques besides insufficient description of the adopted procedures. Not long, autologous platelet-rich plasma (PRP) has surfaced strongly in diverse medical specialties including plastic, wound healing and diabetic ulcers, orthopedic, trauma, ocular surgery, dry eye for eyelid injection, urology for urinary incontinence, sexual wellness, cutaneous surgery, sport medicine, dentistry and dermatology, and aesthetic applications. PRP proved to promote wound healing and aid in facelift, volumetric skin, skin rejuvenation, regeneration, and reconstruction; improve wrinkling; stimulate hair growth; increase hair follicle viability and its survival rate; prevent apoptosis; increase and prolong the anagen hair growth stage; and delay the progression to catagen hair cycle stage with increased density in hair loss and hair transplantation. The aims of this extensive review were to cover all PRP application aspects that are carried out in aesthetic dermatology and to assess the literature on platelet-rich plasma outcomes on main aesthetic practices of general

Complications of minimally invasive cosmetic procedures: Prevention and management

Directory of Open Access Journals (Sweden)

Lauren L Levy

2012-01-01

Full Text Available Over the past decade, facial rejuvenation procedures to circumvent traditional surgery have become increasingly popular. Office-based, minimally invasive procedures can promote a youthful appearance with minimal downtime and low risk of complications. Injectable botulinum toxin (BoNT, soft-tissue fillers, and chemical peels are among the most popular non-invasive rejuvenation procedures, and each has unique applications for improving facial aesthetics. Despite the simplicity and reliability of office-based procedures, complications can occur even with an astute and experienced injector. The goal of any procedure is to perform it properly and safely; thus, early recognition of complications when they do occur is paramount in dictating prevention of long-term sequelae. The most common complications from BoNT and soft-tissue filler injection are bruising, erythema and pain. With chemical peels, it is not uncommon to have erythema, irritation and burning. Fortunately, these side effects are normally transient and have simple remedies. More serious complications include muscle paralysis from BoNT, granuloma formation from soft-tissue filler placement and scarring from chemical peels. Thankfully, these complications are rare and can be avoided with excellent procedure technique, knowledge of facial anatomy, proper patient selection, and appropriate pre- and post-skin care. This article reviews complications of office-based, minimally invasive procedures, with emphasis on prevention and management. Practitioners providing these treatments should be well versed in this subject matter in order to deliver the highest quality care.

An in vitro study of the effects of low-level laser radiation on human blood

Science.gov (United States)

Siposan, Dan G.; Lukacs, Adalbert

2003-12-01

In the last time the study of the effects of LLLR on the blood is considered to be a subject of great importance in elucidating the mechanisms of action between LLLR and biologic tissues. Different methods of therapy by blood irradiation have been developed and used in clinical purposes with benefic effects. This study investigates some in vitro effects of LLLR on some selected rheologic indices of human blood. After establishing whether or not damaging effects could appear due to laser irradiation of the blood, we tried to find a new method for rejuvenating the blood preserved in MacoPharma-type bags. Blood samples were obtained from adult regular donors (volunteers). HeNe laser and laser diodes were used as radiation source, in a wide range of wavelengths, power densities, doses and other parameters of irradiation protocol. In the first series of experiments we established that LLLR does not alter the fresh blood from healthy donors, for doses between 0 and 10 J/cm3 and power densities between 30 and 180 mW/cm3. In the second series of experiments we established that LLLR does have, in some specific conditions, a revitalizing effect on the erythrocytes in preserved blood. We concluded that laser irradiation of the preserved blood, following a selected protocol of irradiation, could be used as a new method to improve the performances of preservation: prolonging the period of storage and blood rejuvenation before transfusion.

Origin of the Blue Ridge escarpment along the passive margin of Eastern North America

Science.gov (United States)

Spotila, J.A.; Bank, G.C.; Reiners, P.W.; Naeser, C.W.; Naeser, N.D.; Henika, B.S.

2004-01-01

The Blue Ridge escarpment is a rugged landform situated within the ancient Appalachian orogen. While similar in some respects to the great escarpments along other passive margins, which have evolved by erosion following rifting, its youthful topographic expression has inspired proposals of Cenozoic tectonic rejuvenation in eastern North America. To better understand the post-orogenic and post-rift geomorphic evolution of passive margins, we have examined the origin of this landform using low-temperature thermochronometry and manipulation of topographic indices. Apatite (U-Th)/He and fission-track analyses along transects across the escarpment reveal a younging trend towards the coast. This pattern is consistent with other great escarpments and fits with an interpretation of having evolved by prolonged erosion, without the requirement of tectonic rejuvenation. Measured ages are also comparable specifically to those measured along other great escarpments that are as much as 100 Myr younger. This suggests that erosional mechanisms that maintain rugged escarpments in the early post-rift stages may remain active on ancient passive margins for prolonged periods. The precise erosional evolution of the escarpment is less clear, however, and several end-member models can explain the data. Our preferred model, which fits with all data, involves a significant degree of erosional escarpment retreat in the Cenozoic. Although this suggests that early onset of topographic stability is not required of passive margin evolution, more data are required to better constrain the details of the escarpment's development. ?? 2003 Blackwell Publishing Ltd.

National brownfield redevelopment strategy: Executive summary

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-02-01

Brownfields refer to contaminated land which lies unused and unproductive. The potential for rejuvenation of such lands exist, which would bring health and economic benefits to local communities, as numerous sites are located in urban areas. The National Round Table on the Environment and the Economy (NRTEE) agreed, upon request from the government of Canada. to develop a redevelopment strategy designed specifically for brownfields. It is estimated that there are some 30,000 brownfield sites in Canada, such as former railway yards, decommissioned refineries, old waterfronts and riverbanks, crumbling warehouses, abandoned gas stations, former dry cleaners and other commercial properties where toxic substances were either used or stored. The rejuvenation of such sites results in economic, social, and environmental benefits through the creation of numerous jobs, millions of dollars in additional property taxes, as well as thousands of new housing units. There are several challenges in cleaning up those sites: lack of access to capital, regulatory liability risk, civil liability risk, limited access to insurance protection, regulatory delays, stigma and risk perception, and lack or awareness among many key public and private sector groups. This document presents the national strategy developed to address those issues. Three strategic directions have been identified for action: (1) applying strategic public investments to address up front costs, (2) establishing an effective public policy regime for environmental liability and risk management, and (3) building capacity for and community awareness of brownfield redevelopment. Recommendations and the rationale were presented under each proposal.

Cave development in an uplifting fold-and-thrust belt of the Tatra Mountains, Poland

Directory of Open Access Journals (Sweden)

Jacek Szczygiel

2015-09-01

Full Text Available Detailed structural analysis and geomorphological observations supplemented by the analysis of the distribution of karst conduit directions have been performed in 23 morphologically diverse caves in the Tatra Mountains. Based on these studies, a development scheme of vadose cave passages has been proposed for the most common geological settings in the fold-and-thrust-belt: (1 single-plain faults, (2 multiple fault cores, (3 bedding plane fractures and (4 hinge zones of recumbent folds. Results indicate that the dynamics of the massif (local gravity sliding in the nearby slope zone and regional stress fields, along with the structural pattern, influences the predisposition of structural and stratigraphic discontinuities to karst drainage. Constant tectonic stress fields affected the massif during the entire speleogenesis. This led to the rejuvenation of the same displacements in successive tectonic events, which resulted in promoting this reactivated structures in successive speleogenetic phases. Structures along which older cave levels had developed were also utilized later by vadose and phreatic drainage, leading to the intersection of the vadose passages with elevated paleo-phreatic cave levels. Independently, formation of entirely vadose caves, guided by the same group of weak and rejuvenated planes, was enabled. In the Tatras, the concentric and recumbent geometry of the main folds resulted in steep dipping of the bedding planes over a distance up to a few hundred meters which makes the bedding plane fractures subject to karst water circulation in these geologic and geodynamic settings.

Review of soft tissue augmentation in the face

Directory of Open Access Journals (Sweden)

James Newman

2009-08-01

Full Text Available James NewmanFacial Plastic Surgery, Stanford University Medical Center, Palo Alto, CAFacial Plastic Surgery, Stanford University Medical Center, Palo Alto, CA, USAAbstract: A primary pillar of facial rejuvenation is the replacement of soft tissue atrophy via a variety of augmentation techniques. The techniques can be classified into three categories, skeletal onlay grafts, subcutaneous volumizers, and dermal fillers. While onlay grafts and subcutaneous volumizers have the most persistent results, the emergence of improved dermal fillers in the past 5 years has become increasingly popular. An accurate diagnosis of the level(s of soft tissue atrophy in the face needs to be made prior to selection of the category or combination of techniques. In the younger patient, the selection of a dermal filler or combination of fillers can be adequate for treatment. A comparison of the composition and characteristics of the available dermal fillers are discussed in detail to assist the clinician in understanding the actual mechanism of soft tissue augmentation. In the more advanced aging face, a combination of the three categories may be necessary to produce optimal results. Just as dermal fillers have become more differentiated to increase their longevity, the non-injectible long-lasting implants are becoming more developed to mimic accurate viscoelastic properties of the facial soft tissues. All three classes of augmentation techniques can provide patients with very satisfactory results as part of overall facial rejuvenation.Keywords: soft tissue, dermal fillers, facial implants, facial augmentation

Effects of donor plant age and explants on in vitro culture of Cedrela montana Moritz ex Turcz

Directory of Open Access Journals (Sweden)

Sofía Basto

2012-12-01

Full Text Available To evaluate the organogenic potential of Cedrela montana Moritz ex Turcz. Explants from mature (10-20 year-old and juvenile (7-18 month-old trees were collected. The first grouping included buds, leaves, and nodes derived from juvenile basal offshoots and rejuvenated shoots from cuttings. The second, included leaves, petioles, nodes, internodes and nodes of in vitro elongated shoots. The highest organogenic potential was observed in nodes from juvenile trees: 45.8% of explants presented axillary bud elongation, while 56.2% presented rooting in a growth regulator free culture medium. Fifty-one percent of elongated shoots produced adventitious shoots with 0.5 μM NAA and 0.5 μM BA; 30% with 0.5 μM NAA and 1 μM BA; and 30% with 1 μM BA. Twenty percent presented roots with 0.5 μM NAA. Root formation was stimulated in a medium supplemented with activated charcoal (5 gL-1. The acclimatization of eighty percent of plantlets regenerated from nodes, and of 72.5% in vitro generated shoots was successful. On the contrary, mature trees material presented low organogenic response. Axillary bud elongation was recorded just in 10.7% of explants from juvenile shoots and in 6.7% of explants from rejuvenated shoots. The age of donor plant and type of explant affect the organogenic potential of C. montana. This study contributes to the understanding of this species’ response under in vitro conditions.

Evolutionary perspectives on ageing.

Science.gov (United States)

Reichard, Martin

2017-10-01

From an evolutionary perspective, ageing is a decrease in fitness with chronological age - expressed by an increase in mortality risk and/or decline in reproductive success and mediated by deterioration of functional performance. While this makes ageing intuitively paradoxical - detrimental to individual fitness - evolutionary theory offers answers as to why ageing has evolved. In this review, I first briefly examine the classic evolutionary theories of ageing and their empirical tests, and highlight recent findings that have advanced our understanding of the evolution of ageing (condition-dependent survival, positive pleiotropy). I then provide an overview of recent theoretical extensions and modifications that accommodate those new discoveries. I discuss the role of indeterminate (asymptotic) growth for lifetime increases in fecundity and ageing trajectories. I outline alternative views that challenge a universal existence of senescence - namely the lack of a germ-soma distinction and the ability of tissue replacement and retrogression to younger developmental stages in modular organisms. I argue that rejuvenation at the organismal level is plausible, but includes a return to a simple developmental stage. This may exempt a particular genotype from somatic defects but, correspondingly, removes any information acquired during development. A resolution of the question of whether a rejuvenated individual is the same entity is central to the recognition of whether current evolutionary theories of ageing, with their extensions and modifications, can explain the patterns of ageing across the Tree of Life. Copyright © 2017 Elsevier Ltd. All rights reserved.

Optimal Overhaul-Replacement Policies for Repairable Machine Sold with Warranty

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Kusmaningrum Soemadi

2014-12-01

Full Text Available This research deals with an overhaul-replacement policy for a repairable machine sold with Free Replacement Warranty (FRW. The machine will be used for a finite horizon, T (T <, and evaluated at a fixed interval, s (s< T. At each evaluation point, the buyer considers three alternative decisions i.e. Keep the machine, Overhaul it, or Replace it with a new identical one. An overhaul can reduce the machine age virtually, but not to a point that the machine is as good as new. If the machine fails during the warranty period, it is rectified at no cost to the buyer. Any failure occurring before and after the expiry of the warranty is restored by minimal repair. An overhaul-replacement policy is formulated for such machines by using dynamic programming approach to obtain the buyer’s optimal policy. The results show that a significant rejuvenation effect due to overhaul may extend the length of machine life cycle and delay the replacement decision. In contrast, the warranty stimulates early machine replacement and by then increases the replacement frequencies for a certain range of replacement cost. This demonstrates that to minimize the total ownership cost over T the buyer needs to consider the minimal repair cost reduction due to rejuvenation effect of overhaul as well as the warranty benefit due to replacement. Numerical examples are presented for both illustrating the optimal policy and describing the behavior of the optimal solution.

Mesotherapy

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Vedamurthy Maya

2007-01-01

Full Text Available Mesotherapy is a technique which involves microinjections of conventional homeopathic medication and/ or vitamins into the mesoderm or middle layer of the skin to promote healing or corrective treatment to a specific area of the body. It is a debatable addition in the therapeutic armamentarium in the management of skin rejuvenation. However, dermatologists have to use this cautiously and judiciously as at present there is a lot of controversy regarding its efficacy and safety despite the fact that mesotherapy is gaining popularity in the West.

Skin resurfacing procedures: new and emerging options.

Science.gov (United States)

Loesch, Mathew M; Somani, Ally-Khan; Kingsley, Melanie M; Travers, Jeffrey B; Spandau, Dan F

2014-01-01

The demand for skin resurfacing and rejuvenating procedures has progressively increased in the last decade and has sparked several advances within the skin resurfacing field that promote faster healing while minimizing downtime and side effects for patients. Several technological and procedural skin resurfacing developments are being integrated into clinical practices today allowing clinicians to treat a broader range of patients' skin types and pathologies than in years past, with noteworthy outcomes. This article will discuss some emerging and developing resurfacing therapies and treatments that are present today and soon to be available.

Devonian lacustrine shore zone architecture imaged with ground penetrating radar

DEFF Research Database (Denmark)

Andrews, Steven D.; Moreau, Julien; Archer, Stuart

. The shore zone sandstones overlie playa facies which contain abundant desiccation horizons, reflecting the most arid phase in the climatically controlled lacustrine cycle. As climatic conditions ameliorated the rejuvenation of fluvial systems resulted in the transport of sand out into the basin. Initial...... deposition was limited to intermittent events where sediment was laid down on a water saturated substrate. Some of these may have occurr­­­ed subaqueously as small scale turbidity flows. High resolution fluctuations in lake level resulted in periodic short lived reworking events along the lake margin which...

The new A-Class from Mercedes-Benz; Die neue A-Klasse von Mercedes-Benz

Energy Technology Data Exchange (ETDEWEB)

Liebl, Johannes; Siebenpfeiffer, Wolfgang (eds.)

2012-09-15

The dynamic style of the new A-Class of Mercedes-Benz also is present in the interior: operating systems, display systems and telematics underwent a rejuvenation. Whether Drive Kit Plus for the iPhone or the multimedia system Comand Online, everything is tailored to the driver. Also in terms of safety, standards were set: radar-based collision warning system and fatigue detector Attention Assist, the new A-Class also is distinguished by a new energy efficiency and emission reduction. The drag coefficient of 0.27 sets a benchmark in this class.

Differential geometry

CERN Document Server

Ciarlet, Philippe G

2007-01-01

This book gives the basic notions of differential geometry, such as the metric tensor, the Riemann curvature tensor, the fundamental forms of a surface, covariant derivatives, and the fundamental theorem of surface theory in a selfcontained and accessible manner. Although the field is often considered a classical one, it has recently been rejuvenated, thanks to the manifold applications where it plays an essential role. The book presents some important applications to shells, such as the theory of linearly and nonlinearly elastic shells, the implementation of numerical methods for shells, and

Effect of long-term physical aging on the kinetic parameters in a common pharmaceutical drug: Flutab

International Nuclear Information System (INIS)

Abu-Sehly, A.A.; Elabbar, A.A.

2011-01-01

Differential scanning calorimetry (DSC) measurements were performed to investigate the effects of long-term physical aging on kinetic parameters of the pharmaceutical drug (Flutab). Kinetics parameters such as activation energy (E) and fragility parameter (m) of the glass transition for aged and rejuvenated glasses were determined using different kinetic models. Evidence of variation of E with temperature is presented. It is shown in this work that natural storage of the drug introduced significant physical aging as indicated by changes in the glass transition temperature, activation energy and fragility parameter.

Autologous fat grafting for cosmetic enhancement of the perioral region.

Science.gov (United States)

Glasgold, Mark; Lam, Samuel M; Glasgold, Robert

2007-11-01

The role of volume loss in the progression of facial aging is widely accepted as an important cause. The aging appearance of the perioral region and lower face is significantly affected by this volume loss, which contributes to the development of labiomental folds, the loss of definition of the jawline, and worsening of skin texture, among other manifestations. Autologous fat transfer can effectively replace this lost volume and contribute to any facial rejuvenation plan. Fat can replace larger volumes than off-the-shelf fillers and provides a potentially permanent solution.

The importance of the prejowl notch in face lifting: the prejowl implant.

Science.gov (United States)

Shire, James R

2008-02-01

This article reviews the anatomy of the lower face in light of approach and techniques for prejowl implant. Implant sizing, patient selection and analysis, technique, and complications are presented. The author cites the manner of aging in the lower face and discusses the concept of augmenting the mandible to re-establish a youthful contour by correcting the prejowl sulcus and chin for rejuvenation. Because the prejowl sulcus and jowling camouflage the jawline, recontouring the mandible with implants restores the smooth jawline to provide optimal result by restoring the oval face shape.

The politics of mother tongue education: The case of Uganda

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Ssentanda, Medadi Erisa

2016-12-01

Full Text Available This paper aims to explain the trend of mother tongue (MT education in Uganda by examining particularly government’s practices towards MT education. MT education was (reintroduced in Uganda in 2006/2007 due to disappointing literacy acquisition by learners with the hope of improving literacy skills among particularly rural children. Based on data gathered from rural government and private schools in rural areas, this paper questions what exactly it is that government seeks to reclaim, restore and/or rejuvenate in Uganda’s education system via MT education.

Dermatologic care of the transgender patient

Directory of Open Access Journals (Sweden)

B.A. Ginsberg, MD

2017-03-01

Full Text Available Given the complexities of the transitioning process, transgender individuals may face unique dermatologic needs in addition to routine care. Exogenous hormones affect hair and sebum production, gender-confirming surgeries often require dermatologic pre- and postoperative interventions, and postoperative anatomy may show unique presentations of routine skin conditions. Aesthetic techniques that are often used for rejuvenation may have a role in facial feminization and masculinization and unfortunately are too frequently performed by nonmedical personnel with negative consequences. Ultimately, physicians should strive to make their office a more accommodating environment for transgender individuals.

The "One Belt and One Road" :the Bridge between the Chinese Dream and the World Dream

Institute of Scientific and Technical Information of China (English)

Zhao; Zhouxian; Liu; Guang

2015-01-01

To build the "One Belt and One Road" is the profound strategic conception put forward by the CPC Central Committee with Comrade Xi Jinping as the General Secretary,focusing on adherence to and further development of socialism with Chinese characteristics and realizing the Chinese dream of great rejuvenation of the Chinese nation.To seize the opportunity to promote implementation of the strategic conception is bound to open up a new situation and create new opportunities to realize the Chinese dream,and will inject more new energy and new vitality into the world dream.

Det sidste nye og det gode gamle

DEFF Research Database (Denmark)

Gemzøe, Anker

2014-01-01

prose is passing on and even rejuvenating prosaic subgenres such as love stories, biographical novels often linked to family and native soil, and crime novels. Complementary to the genre-transgressive push factor, a genre-confirming pull factor is in play; for this I propose the term bestseller......Since the Millennium, prose has been dominating the Danish literary scene, with its inherent obsession with both “making it new” (novella and novel: news) and “preserving the old”; love, family and crime. The boundlessly flexible prose is invading the other main genres. Incorporating contemporary...

Post-apartheid representations of youth in the Zulu novel Kungasa ngifile

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N.S. Zulu

2004-07-01

Full Text Available In this article representation of black African youth in the Zulu novel “Kungasa ngifile” is examined. The view is presented that the novel, though seeming to be politically neutral, deals with images of the youth that have ideological concerns in terms of theme, plot action and character portrayal. Such ideological modes of representation seem to be in tune with the present call for moral rejuvenation and the empowerment of the youth who lost opportunities during the liberation struggle. In this respect, the novel backs positive post-apartheid cultural forms.

Lipofilling and PRP for aesthetic facial rejuvenation : Understanding and augmenting the lipograft

NARCIS (Netherlands)

Willemsen, Joep Carlus Natasja

2018-01-01

Nieuwe inzichten in gezichtsveroudering maakten duidelijk dat niet alleen verzakking/ ptosis, maar ook verlies van gelaatsverlies een belangrijke factor is in dit proces. Klassieke gezichtsverjongingsprocedures die alleen weefsel optillen of herpositioneren in een verticale vector corrigeerden niet

REJUVENATING THE MATTER POWER SPECTRUM: RESTORING INFORMATION WITH A LOGARITHMIC DENSITY MAPPING

International Nuclear Information System (INIS)

Neyrinck, Mark C.; Szalay, Alexander S.; Szapudi, Istvan

2009-01-01

We find that nonlinearities in the dark matter power spectrum are dramatically smaller if the density field first undergoes a logarithmic mapping. In the Millennium simulation, this procedure gives a power spectrum with a shape hardly departing from the linear power spectrum for k ∼ -1 at all redshifts. Also, this procedure unveils pristine Fisher information on a range of scales reaching a factor of 2-3 smaller than in the standard power spectrum, yielding 10 times more cumulative signal to noise at z = 0.

What do women want in breast reconstruction? Age-adhered surgery or rejuvenation?

Directory of Open Access Journals (Sweden)

Helga Henseler

2015-06-01

Conclusion: The majority of women desire to recreate their own natural and ptotic breast shape in reconstructive surgery without contralateral adjusting surgery. Younger women with smaller breasts and women of all ages with a family history of breast cancer more frequently prefer an operation on only the involved side. Women opted for good rather than excellent breast symmetry.

Use of Platelet Preparations in Facial Rejuvenation and Wound Healing Remains Unproven.

Science.gov (United States)

Kenworthy, William; Langridge, Benjamin; Patel, Nakul; Waterhouse, Norman

2016-04-01

There is growing interest in the use of platelet derivatives in facial aesthetic surgery and wound healing. Sclafani et al. have concluded from their review of the literature that the vast majority of studies show a significant and measurable effect on facial aesthetic outcomes with the use of these platelet preparations. We suggest that an alternative review of the same literature may well have produced a different set of conclusions. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Skin rejuvenating effects of chemical peeling: a study in photoaged hairless mice.

Science.gov (United States)

Han, Sung Hyup; Kim, Hong Jig; Kim, Si Yong; Kim, You Chan; Choi, Gwang Seong; Shin, Jeong Hyun

2011-09-01

Chemical peeling is a dermatologic treatment for skin aging. However, the mechanism by which the chemical peel achieves its results is not clear. We investigated the effects of chemical peeling and the mechanism of wrinkle reduction in photoaged hairless mice skin. After inducing photoaged skin in hairless mice by repetitive ultraviolet-B irradiation applied over 14 weeks, we applied trichloroacetic acid (TCA) 30%, TCA 50%, and phenol on areas of the same size on the backs of the mice. Punch biopsies were obtained 7, 14, 28, and 60 days after the procedure for histologic and immunohistochemical analyses. Histologic examination showed an increase in dermal thickness, collagen fibers, and elastic fibers in the dermis of intervention groups compared with control groups. These increases were maintained significantly for 60 days. This study demonstrates that chemical peeling reduces wrinkles and regenerates skin by increasing dermal thickness and the amount of collagen and elastic fibers in photoaged skin. © 2011 The International Society of Dermatology.

Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation.

Science.gov (United States)

McDaniel, David H; Hamzavi, Iltefat H; Zeichner, Joshua A; Fabi, Sabrina G; Bucay, Vivian W; Harper, Julie C; Comstock, Jody A; Makino, Elizabeth T; Mehta, Rahul C; Vega, Virginia L

2015-07-01

For more than a century, solar radiation has been known to contribute significantly to the extrinsic aging of skin. Until recently, this was almost exclusively attributed to the photodamage caused by ultraviolet (UV) light. However, a growing body of evidence now indicates that both infrared (IR) and visible light may also contribute to extrinsic skin aging. Infrared radiation, comprised of IR-A, IR-B, and IR-C, accounts for 54.3% of the total solar radiation reaching the skin. Studies have shown that IR radiation is also responsible for skin aging. Thus, IR-A radiation regulates hundreds of genes in skin, with roles in extracellular matrix (ECM) homeostasis regulation, apoptosis, cell growth, and stress responses. IR-B and IR-C radiation are primarily responsible for the increase in skin temperature associated with solar exposure, and are implicated in heat-related skin destruction of collagen and elastin, which is characterized by an increase in the expression of matrix metalloproteinases (MMPs). The contribution of visible light to photoaging is less well understood; however, some preliminary indication associates visible light with the upregulation of MMPs' expression, DNA damage, and keratinocyte proliferation. Interestingly, the common denominator that links skin damage to the different solar wavelengths is the enhanced production of reactive molecule species (RMS) and therewith increased oxidative stress. SkinMedica® Total Defense + Repair (TD+R; SkinMedica Inc., an Allergan company, Irvine, CA) is a "superscreen," which combines broad spectrum UV protection with a unique blend of antioxidants (SOL-IR Advanced Antioxidant Complex™) that provide protection from IR radiation while promoting skin repair. Preclinical studies have indicated that TD+R SPF34 prevents the formation of UV-induced sunburn cells and cyclobutane pyrimidine dimers while preserving or improving the expression of ECM genes. In addition, it prevents IR-A-triggered fragmentation of elastin fibers and expression of MMP-1. Initial clinical studies indicate that TDR+R SPF34 reduces the increase in surface temperature seen with IR radiation. A significant improvement in the appearance of lines and wrinkles was reported as early as week 2 in patients using TDR+R SPF34. In summary, we observed that the unique blend of antioxidants present in TD+R acts in harmony with SPF active ingredients, expanding solar protection beyond UV radiation and counterbalancing the deleterious effects of free radicals on skin cells by promoting endogenous repair.

Perioral rejuvenation: restoration of attractiveness in aging females by minimally invasive procedures

Directory of Open Access Journals (Sweden)

Wollina U

2013-09-01

Full Text Available Uwe Wollina Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany Abstract: Lips and the perioral area are of outstanding importance in youthful appearance, attractiveness, and beauty. In contrast to younger and middle aged females, there is only scant published data on minimally invasive procedures to restore and revitalize lips and perioral soft tissue in elderly females. In this review we report the signs of aging in this particular region and the underlying anatomy. We review studies on lip restoration in younger females and present our techniques for elderly women. With an individually tailored approach, elderly females benefit from minimally invasive techniques. Keywords: facial aging, perioral soft tissue, lips, dermal fillers, anatomy

Therapeutic opportunities: Telomere maintenance in inducible pluripotent stem cells

Energy Technology Data Exchange (ETDEWEB)

Gourronc, Francoise A. [Department of Microbiology, University of Iowa (United States); Klingelhutz, Aloysius J., E-mail: al-klingelhutz@uiowa.edu [Department of Microbiology, University of Iowa (United States)

2012-02-01

It has been demonstrated that exogenous expression of a combination of transcription factors can reprogram differentiated cells such as fibroblasts and keratinocytes into what have been termed induced pluripotent stem (iPS) cells. These iPS cells are capable of differentiating into all the tissue lineages when placed in the right environment and, in the case of mouse cells, can generate chimeric mice and be transmitted through the germline. Safer and more efficient methods of reprogramming are rapidly being developed. Clearly, iPS cells present a number of exciting possibilities, including disease modeling and therapy. A major question is whether the nuclei of iPS cells are truly rejuvenated or whether they might retain some of the marks of aging from the cells from which they were derived. One measure of cellular aging is the telomere. In this regard, recent studies have demonstrated that telomeres in iPS cells may be rejuvenated. They are not only elongated by reactivated telomerase but they are also epigenetically modified to be similar but not identical to embryonic stem cells. Upon differentiation, the derivative cells turn down telomerase, the telomeres begin to shorten again, and the telomeres and the genome are returned to an epigenetic state that is similar to normal differentiated somatic cells. While these preliminary telomere findings are promising, the overall genomic integrity of reprogrammed cells may still be problematic and further studies are needed to examine the safety and feasibility of using iPS cells in regenerative medicine applications.

Therapeutic opportunities: Telomere maintenance in inducible pluripotent stem cells

International Nuclear Information System (INIS)

Gourronc, Francoise A.; Klingelhutz, Aloysius J.

2012-01-01

It has been demonstrated that exogenous expression of a combination of transcription factors can reprogram differentiated cells such as fibroblasts and keratinocytes into what have been termed induced pluripotent stem (iPS) cells. These iPS cells are capable of differentiating into all the tissue lineages when placed in the right environment and, in the case of mouse cells, can generate chimeric mice and be transmitted through the germline. Safer and more efficient methods of reprogramming are rapidly being developed. Clearly, iPS cells present a number of exciting possibilities, including disease modeling and therapy. A major question is whether the nuclei of iPS cells are truly rejuvenated or whether they might retain some of the marks of aging from the cells from which they were derived. One measure of cellular aging is the telomere. In this regard, recent studies have demonstrated that telomeres in iPS cells may be rejuvenated. They are not only elongated by reactivated telomerase but they are also epigenetically modified to be similar but not identical to embryonic stem cells. Upon differentiation, the derivative cells turn down telomerase, the telomeres begin to shorten again, and the telomeres and the genome are returned to an epigenetic state that is similar to normal differentiated somatic cells. While these preliminary telomere findings are promising, the overall genomic integrity of reprogrammed cells may still be problematic and further studies are needed to examine the safety and feasibility of using iPS cells in regenerative medicine applications.

The Origin of Widespread Long-lived Volcanism Across the Galapagos Volcanic Province

Science.gov (United States)

O'Connor, J. M.; Stoffers, P.; Wijbrans, J. R.; Worthington, T. J.

2005-12-01

40Ar/39Ar ages for rocks dredged (SO144 PAGANINI expedition) and drilled (DSDP) from the Galapagos Volcanic Province (Cocos, Carnegie, Coiba and Malpelo aseismic ridges and associated seamounts) show evidence of 1) increasing age with distance from the Galapagos Archipelago, 2) long-lived episodic volcanism at many locations, and 3) broad overlapping regions of coeval volcanism. The widespread nature of synchronous volcanism across the Galapagos Volcanic Province (GVP) suggests a correspondingly large Galapagos hotspot melting anomaly (O'Connor et al., 2004). Development of the GVP via Cocos and Nazca plate migration and divergence over this broad melting anomaly would explain continued multiple phases of volcanism over millions of years following the initial onset of hotspot volcanism. The question arising from these observations is whether long-lived GVP episodic volcanism is equivalent to `rejuvenescent' or a `post-erosional' phase of volcanism that occurs hundreds of thousands or million years after the main shield-building phase documented on many mid-plate seamount chains, most notably along the Hawaiian-Emperor Seamount Chain? Thus, investigating the process responsible for long-lived episodic GVP volcanism provides the opportunity to evaluate this little understood process of rejuvenation in a physical setting very different to the Hawaiian-Emperor Chain (i.e. on/near spreading axis versus mid-plate). We consider here timing and geochemical information to test the various geodynamic models proposed to explain the origin of GVP hotspot volcanism, especially the possibility of rejuvenated phases that erupt long after initial shield-building.

Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging.

Science.gov (United States)

Coder, Brandon; Wang, Weikan; Wang, Liefeng; Wu, Zhongdao; Zhuge, Qichuan; Su, Dong-Ming

2017-01-24

The interaction between T cells and the central nervous system (CNS) in homeostasis and injury has been recognized being both pathogenic (CD4+ T-helper 1 - Th1, Th17 and γδT) and ameliorative (Th2 and regulatory T cells - Tregs). However, in-depth studies aimed to elucidate the precise in the aged microenvironment and the dichotomous role of Tregs have just begun and many aspects remain unclear. This is due, not only to a mutual dependency and reciprocal causation of alterations and diseases between the nervous and T cell immune systems, but also to an inconsistent aging of the two systems, which dynamically changes with CNS injury/recovery and/or aging process. Cellular immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution - sources of chronic inflammation in the elderly (termed inflammaging), potentially induces an acceleration of brain aging and memory loss. In turn, aging of the brain via neuro-endocrine-immune network drives total body systemic aging, including that of the immune system. Therefore, immunotherapeutics including vaccination and "protective autoimmunity" provide promising means to rejuvenate neuro-inflammatory disorders and repair CNS acute injury and chronic neuro-degeneration. We review the current understanding and recent discoveries linking the aging immune system with CNS injury and neuro-degeneration. Additionally, we discuss potential recovery and rejuvenation strategies, focusing on targeting the aging T cell immune system in an effort to alleviate acute brain injury and chronic neuro-degeneration during aging, via the "thymus-inflammaging-neurodegeneration axis".

Micron-pore-sized metallic filter tube membranes for filtration of particulates and water purification.

Science.gov (United States)

Phelps, T J; Palumbo, A V; Bischoff, B L; Miller, C J; Fagan, L A; McNeilly, M S; Judkins, R R

2008-07-01

Robust filtering techniques capable of efficiently removing particulates and biological agents from water or air suffer from plugging, poor rejuvenation, low permeance, and high backpressure. Operational characteristics of pressure-driven separations are in part controlled by the membrane pore size, charge of particulates, transmembrane pressure and the requirement for sufficient water flux to overcome fouling. With long term use filters decline in permeance due to filter-cake plugging of pores, fouling, or filter deterioration. Though metallic filter tube development at ORNL has focused almost exclusively on gas separations, a small study examined the applicability of these membranes for tangential filtering of aqueous suspensions of bacterial-sized particles. A mixture of fluorescent polystyrene microspheres ranging in size from 0.5 to 6 microm in diameter simulated microorganisms in filtration studies. Compared to a commercial filter, the ORNL 0.6 microm filter averaged approximately 10-fold greater filtration efficiency of the small particles, several-fold greater permeance after considerable use and it returned to approximately 85% of the initial flow upon backflushing versus 30% for the commercial filter. After filtering several liters of the particle-containing suspension, the ORNL composite filter still exhibited greater than 50% of its initial permeance while the commercial filter had decreased to less than 20%. When considering a greater filtration efficiency, greater permeance per unit mass, greater percentage of rejuvenation upon backflushing (up to 3-fold), and likely greater performance with extended use, the ORNL 0.6 microm filters can potentially outperform the commercial filter by factors of 100-1,000 fold.

Efficacy of long pulse Nd:YAG laser versus fractional Er:YAG laser in the treatment of hand wrinkles.

Science.gov (United States)

Robati, Reza M; Asadi, Elmira; Shafiee, Anoosh; Namazi, Nastaran; Talebi, Atefeh

2018-04-01

There are different modalities for hand rejuvenation. Fractional Er:YAG laser and long pulse Nd:YAG laser were introduced for treating hand wrinkles. We plan to compare fractional Er:YAG laser and long pulse Nd:YAG laser in a randomized controlled double-blind design with multiple sessions and larger sample size in comparison with previous studies. Thirty-three participants with hand wrinkles entered this study. They were randomly allocated to undergo three monthly laser treatments on each hand, one with a fractional Er:YAG laser and the other with a long pulse Nd:YAG laser. The evaluations included assessment of clinical improvement determined by two independent dermatologists not enrolled in the treatment along with measuring skin biomechanical property of hands using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT). Moreover, potential side effects and patients' satisfaction have been documented at baseline, 1 month after each treatment, and 3 months after the final treatment session. Clinical evaluation revealed both modalities significantly reduce hand wrinkles (p value lasers. Mean CRRT values also decreased significantly after the laser treatment compared to those of the baseline in both laser groups. There was no serious persistent side effect after both laser treatments. Both fractional Er:YAG and long pulse Nd:YAG lasers show substantial clinical improvement of hand skin wrinkles with no serious side effects. However, combination treatment by these lasers along with the other modalities such as fat transfer could lead to better outcomes in hand rejuvenation. IRCT2016032020468N4.

Systems immunology: just getting started.

Science.gov (United States)

Davis, Mark M; Tato, Cristina M; Furman, David

2017-06-20

Systems-biology approaches in immunology take various forms, but here we review strategies for measuring a broad swath of immunological functions as a means of discovering previously unknown relationships and phenomena and as a powerful way of understanding the immune system as a whole. This approach has rejuvenated the field of vaccine development and has fostered hope that new ways will be found to combat infectious diseases that have proven refractory to classical approaches. Systems immunology also presents an important new strategy for understanding human immunity directly, taking advantage of the many ways the immune system of humans can be manipulated.

Soft tissue augmentation - Use of hyaluronic acid as dermal filler

Directory of Open Access Journals (Sweden)

Vedamurthy Maya

2004-11-01

Full Text Available Soft tissue augmentation has revolutionized the treatment of the aging face. It is a technique in which a substance is injected under the skin. The concept of utilizing materials for soft tissue augmentation actually began around 1950 with the use of fluid silicone. Today we have a large armamentarium of implant materials to delay the tell tale signs of aging. Filling has replaced conventional surgery in facial rejuvenation. In this article, the emphasis will be on hyaluronic acid as this substance is easily available in India and ranks among the most widely used dermal fillers.

Soft tissue augmentation - Use of hyaluronic acid as dermal filler

Directory of Open Access Journals (Sweden)

Vedamurthy Maya

2004-01-01

Full Text Available Soft tissue augmentation has revolutionized the treatment of the aging face. It is a technique in which a substance is injected under the skin. The concept of utilizing materials for soft tissue augmentation actually began around 1950 with the use of fluid silicone. Today we have a large armamentarium of implant materials to delay the tell tale signs of aging. Filling has replaced conventional surgery in facial rejuvenation. In this article, the emphasis will be on hyaluronic acid as this substance is easily available in India and ranks among the most widely used dermal fillers.

Has the Effect of Mesotherapy Been Proved?

Directory of Open Access Journals (Sweden)

Gonca Gökdemir

2009-06-01

Full Text Available Mesotherapy is a medical technique that consist of the intracutaneous or subcutaneous injection to the diseased area. It has become as a populer treatment method in cosmetic dermatology recently. Mesotherapy has been used in the treatment of skin rejuvenation, cellulite and localized fat reduction. Substances using in mesotherapy are plant extracts, homeopathic agents, vitamins, and some pharmaceuticals. The effect of these agents are not completely known. There are few experimental and clinical studies evaluating the efficacy of mesotherapy in any form. In this report, it has been reviewed studies about the effect of compounds commonly used in mesotherapy in literature.

Plasma skin resurfacing: personal experience and long-term results.

Science.gov (United States)

Bentkover, Stuart H

2012-05-01

This article presents a comprehensive clinical approach to plasma resurfacing for skin regeneration. Plasma technology, preoperative protocols, resurfacing technique, postoperative care, clinical outcomes, evidence-based results, and appropriate candidates for this procedure are discussed. Specific penetration depth and specific laser energy measurements are provided. Nitrogen plasma skin regeneration is a skin-resurfacing technique that offers excellent improvement of mild to moderate skin wrinkles and overall skin rejuvenation. It also provides excellent improvement in uniformity of skin color and texture in patients with hyperpigmentation with Fitzpatrick skin types 1 through 4. Copyright © 2012 Elsevier Inc. All rights reserved.

Visual observation of digitalised signals by workstations

International Nuclear Information System (INIS)

Navratil, J.; Akiyama, A.; Mimashi, T.

1994-01-01

The idea to have on-line information about the behavior of betatron tune, as a first step to the future automatic control of TRISTAN accelerator tune, appeared near the end of 1991. At the same time, other suggestions concerning a rejuvenation of the existing Control System arose and therefore the newly created project ''System for monitoring betatron tune'' (SMBT) started with several goals: - to obtain new on-line information about the beam behavior during the acceleration time, - to test the way of possible extension and replacement of the existing control system of TRISTAN, - to get experience with the workstation and XWindow software

Long-term RF burn-in effects on dielectric charging of MEMS capacitive switches

KAUST Repository

Molinero, David G.; Luo, Xi; Shen, Chao; Palego, Cristiano; Hwang, James; Goldsmith, Charles L.

2013-01-01

This paper experimentally quantified the long-term effects of RF burn-in, in terms of burn-in and recovery times, and found the effects to be semipermanent. Specifically, most of the benefit could be realized after approximately 20 min of RF burn-in, which would then last for several months. Additionally, since similar effects were observed on both real and faux switches, the effects appeared to be of electrical rather than mechanical nature. These encouraging results should facilitate the application of the switches in RF systems, where high RF power could be periodically applied to rejuvenate the switches. © 2001-2011 IEEE.

Long-term RF burn-in effects on dielectric charging of MEMS capacitive switches

KAUST Repository

Molinero, David G.

2013-03-01

This paper experimentally quantified the long-term effects of RF burn-in, in terms of burn-in and recovery times, and found the effects to be semipermanent. Specifically, most of the benefit could be realized after approximately 20 min of RF burn-in, which would then last for several months. Additionally, since similar effects were observed on both real and faux switches, the effects appeared to be of electrical rather than mechanical nature. These encouraging results should facilitate the application of the switches in RF systems, where high RF power could be periodically applied to rejuvenate the switches. © 2001-2011 IEEE.

Common control system for the CERN accelerators

International Nuclear Information System (INIS)

Rausch, R.; Serre, Ch.

1992-01-01

The PS and SPS Accelerator Control Systems are becoming obsolete and need urgent rejuvenation. After a control users forum, where users expressed their needs, two main Working Groups were set up, consisting of Control and Equipment Specialists and experienced Machine Operators. One Working Group studied the architecture and the front-end processing and the other a common approach to the application software needed to run the CERN accelerator complex. The paper presents the technical conclusion of their work and the policy to implement it, taking into account the necessity to operate both machines without interruption of the Physics Program. (author)

Present and future challenges of induced pluripotent stem cells.

Science.gov (United States)

Ohnuki, Mari; Takahashi, Kazutoshi

2015-10-19

Growing old is our destiny. However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate into all cell types by enforced expression of defined transcription factors. The discovery of this induced pluripotent stem cell (iPSC) technology has opened up unprecedented opportunities in regenerative medicine, disease modelling and drug discovery. In this review, we introduce the applications and future perspectives of human iPSCs and we also show how iPSC technology has evolved along the way. © 2015 The Author(s).

The Running Barbed Tie-over Dressing.

Science.gov (United States)

Joyce, Cormac W; Joyce, Kenneth M; Kennedy, Ann-Marie; Kelly, Jack L

2014-04-01

Barbed suture technology is becoming increasingly popular in plastic surgery and is now being used in body contouring surgery and facial rejuvenation. We describe the novel application of a barbed suture as a running tie-over dressing for skin grafts. The barbs act as anchors in the skin, so constant tensioning of the suture is not required. The bidirectional nature of the suture prevents any slippage, and the barbs even act as a grip on the underlying wool dressing. Furthermore, the method described is both quick and simple to learn and would be useful for the sole operator.

The Running Barbed Tie-over Dressing

Directory of Open Access Journals (Sweden)

Cormac W. Joyce, MB, BCh, MRCSI

2014-04-01

Full Text Available Summary: Barbed suture technology is becoming increasingly popular in plastic surgery and is now being used in body contouring surgery and facial rejuvenation. We describe the novel application of a barbed suture as a running tie-over dressing for skin grafts. The barbs act as anchors in the skin, so constant tensioning of the suture is not required. The bidirectional nature of the suture prevents any slippage, and the barbs even act as a grip on the underlying wool dressing. Furthermore, the method described is both quick and simple to learn and would be useful for the sole operator.

Facial aging: A clinical classification

Directory of Open Access Journals (Sweden)

Shiffman Melvin

2007-01-01

Full Text Available The purpose of this classification of facial aging is to have a simple clinical method to determine the severity of the aging process in the face. This allows a quick estimate as to the types of procedures that the patient would need to have the best results. Procedures that are presently used for facial rejuvenation include laser, chemical peels, suture lifts, fillers, modified facelift and full facelift. The physician is already using his best judgment to determine which procedure would be best for any particular patient. This classification may help to refine these decisions.

Neuropathic Pain Following Poly-L-Lactic Acid (Sculptra) Injection.

Science.gov (United States)

Vrcek, Ivan; El-Sawy, Tarek; Chou, Eva; Allen, Theresa; Nakra, Tanuj

Injectable fillers have become a prevalent means of facial rejuvenation and volume expansion. While typically well tolerated, serious complications have been reported. The authors present a case in which an otherwise healthy female with a history of multiple filler injections including poly-L-lactic acid, developed 3 weeks of neuropathic pain in the left temporal fossa following injection. To the best of the authors knowledge, neuropathic pain has not been reported as a complication following poly-L-lactic acid injection. The patient was treated with an injection of steroid and long-acting anesthetic with resolution of symptoms.

Encomium to the Monastic Life: An Unedited Poem of Alexios Makrembolites

Directory of Open Access Journals (Sweden)

Dimitrios Nikou

2016-06-01

Full Text Available This article presents the first critical edition of a metrical Encomium to the monastic life written by the fourteenth-century Byzantine author Alexios Makrembolites. The text is preserved in only one manuscript (Hierosolymitanus Sabbaiticus gr. 417. Makrembolites, after referring to the constant rejuvenation of the nature, wonders why people are drawn towards material goods and not to spiritual ones, distancing themselves from the immortality offered by a life close to God. After apologizing for his sinful life, he praises monastic life which he believes he should follow in order to bring an end to all his pains.

General man-machine interface used in accelerators controls

International Nuclear Information System (INIS)

Boutheon, M.; Di Maio, F.; Pace, A.

1992-01-01

A large community is now using Workstations as Accelerators Computer Controls Interface, through the concepts of windows - menus - synoptics - icons. Some standards were established for the CERN-PS control systems rejuvenation. The Booster-to-PS transfer and injection process is now entirely operated with these tools. This application constitutes a global environment providing the users with the controls, analysis, visualization of a part of an accelerator. Individual commands, measurements, and specialized programs including complex treatments are available in a homogeneous frame. Some months of experience in current operation have shown that this model can be extended to the whole project. (author)

Rejuvenation of the controls of the CERN PS/ISOLDE facility using industrial components

CERN Document Server

Allard, J.; Locci, F.; Mornacchi, G.

2001-01-01

In the context of the general consolidation of the CERN ISOLDE facility, a project has been started to upgrade the ISOLDE control system. We describe the new ISOLDE control system, emphasizing the systematic use of industrial components such as PLCs and field buses, their integration with the existing, VME based, CERN PS control system and their potential applicability to both existing and new controls problems at the CERN PS complex. We also discuss how to extend a PLC-based solution to the case where real-time response is an issue.

Fractional ablative and nonablative radiofrequency for skin resurfacing and rejuvenation of Thai patients.

Science.gov (United States)

Thanasarnaksorn, Wilai; Siramangkhalanon, Vorapot; Duncan, Diane Irvine; Belenky, Inna

2018-04-01

Fractional radiofrequency (RF) technology is often the preferable skin resurfacing treatment, especially among Asian patients. Second generation fractional RF technology has exclusive capability to produce separate biological responses (ablation, coagulation, or a combination of both) with 3 distinguished penetration depth programs. The aim of this study was to evaluate the efficacy and safety of a fractional RF handpiece such as this, on the Thai population. Fifty-five Thai patients were treated with a fractional RF handpiece. The clinical assessment included a pain score, satisfaction survey, physician assessment, a combined patient and physician's assessment of skin condition, and clinical photographic assessments. The wound healing response was evaluated according to 5-time points: immediately after applying a pulse, post 24 hours, post 7 days, post 1 month and post 8 weeks. The obtained patient satisfaction score was "very satisfied" among 74% of the patients, post 3 sessions. Positive correlation was found between patient satisfaction and the physician's assessment. The skin condition assessment showed an increase from an average of 4.2 to 7.9. All treated symptoms improved after each treatment and the clinical outcome lasted at least up to 3-5 months. No significant adverse events were recorded. The in vivo prospective study showed a dose-related response in the deepness of the coagulation injury. In addition, there was evidence for a progressive healing process beginning shortly after exposure and completed within a week. This study clinically and histologically supports the efficacy of fractional RF handpiece in question with a high safety profile. © 2017 Wiley Periodicals, Inc.

Mean Platelet Volume as an Indicator of Platelet Rejuvenation Following Bone Marrow Transplantation.

Science.gov (United States)

1986-07-01

diameter N I Estes, 1968 Mucopolysaccharidosis diameter N I Estes, 1968 Osteogenesis imperfecta diameter N N Estes, 1968 Montreal Platelet Syndrome...6. Inherited Disorders of Connective Tissue: Platelet size was evaluated in 31 families with the following disorders: Osteogenesis imperfecta ...controlled by factors regulating the passage of platelets in and out of the pool. The splenic pool is known to be mobilized following exercise or epinephrine

Applying design thinking concepts to rejuvenate the discipline of operations research/ management science

CSIR Research Space (South Africa)

Viljoen, NM

2009-10-01

Full Text Available problems, thereby bridging the gap between Management Science and Management Consulting. Instead of flogging the proponents of the Management Science domain for losing touch with reality through their “mathematical masturbation" (Ackoff [1]), Corbett...

Platelet-rich plasma and hyaluronic acid - an efficient biostimulation method for face rejuvenation.

Science.gov (United States)

Ulusal, Betul Gozel

2017-03-01

Cosmetic applications of platelet-rich plasma (PRP) are new, and reports are scarce and dispersed in the literature. There are a variety of commercially available kits and injection techniques, and the number and intervals of injections vary. New investigations should focus on developing a standardized procedure for PRP preparation and application methods to augment its efficacy and potency. In this report, we aim to provide data and commentary to assist and add to current guidelines. A series of 94 female patients with varying degrees of facial aging signs were treated with PRP and hyaluronic acid (HA). Mean age was 53.0 ± 5.6. The mean injection number was 3.6 ± 2.0. Platelet-poor and platelet- rich plasma parts were mixed with 0.5 cc %3.5 hyaluronic acid and 0.5 cc procaine and injected with a 30G, 13-mm needle into deep dermis and hypodermis. Patients were asked to rate their personal satisfaction with their skin texture, pigmentation, and sagging. In addition, the overall results were rated by three independent physicians and the patients themselves. The outcomes were peer-reviewed, and correlations between the degree of the aesthetic scores and the number of injections were explored. There was a statistically significant difference in general appearance, skin firmness-sagging and skin texture according to the patients' before and after applications of PRP. A statistically significant correlation was found between the number of injections and overall satisfaction. Compared to the baseline, the PRP and HA injections provided clinically visible and statistically significant improvement on facial skin. The improvements were more remarkable as the injection numbers increased. © 2016 Wiley Periodicals, Inc.

Ablative skin resurfacing with a novel microablative CO2 laser.

Science.gov (United States)

Gotkin, Robert H; Sarnoff, Deborah S; Cannarozzo, Giovanni; Sadick, Neil S; Alexiades-Armenakas, Macrene

2009-02-01

Carbon dioxide (CO2) laser skin resurfacing has been a mainstay of facial rejuvenation since its introduction in the mid 1990s. Recently, a new generation of fractional or microablative CO2 lasers has been introduced to the marketplace. According to the concept of fractional photothermolysis, these lasers ablate only a fraction of the epidermal and dermal architecture in the treatment area. An array of microscopic thermal wounds is created that ablates the epidermis and dermis within very tiny zones; adjacent to these areas, the epidermis and dermis are spared. This microablative process of laser skin resurfacing has proven safe and effective not only for facial rejuvenation, but elsewhere on the body as well. It is capable of improving wrinkles, acne scars, and other types of atrophic scars and benign pigmented lesions associated with elastotic, sun-damaged skin. Because of the areas of spared epidermis and dermis inherent in a procedure that employs fractional photothermolysis, healing is more rapid compared to fully ablative CO2 laser skin resurfacing and downtime is proportionately reduced. A series of 32 consecutive patients underwent a single laser resurfacing procedure with the a new microablative CO2 laser. All patients were followed for a minimum of 6 months and were asked to complete patient satisfaction questionnaires; a 6 month postoperative photographic evaluation by an independent physician, not involved in the treatment, was also performed. Both sets of data were graded and reported on a quartile scale. Results demonstrated greater than 50% improvement in almost all patients with those undergoing treatment for wrinkles, epidermal pigment or solar elastosis deriving the greatest change for the better (>75%).

Effect of ion irradiation on tensile ductility, strength and fictive temperature in metallic glass nanowires

International Nuclear Information System (INIS)

Magagnosc, D.J.; Kumar, G.; Schroers, J.; Felfer, P.; Cairney, J.M.; Gianola, D.S.

2014-01-01

Ion irradiation of thermoplastically molded Pt 57.5 Cu 14.3 Ni 5.7 P 22.5 metallic glass nanowires is used to study the relationship between glass structure and tensile behavior across a wide range of structural states. Starting with the as-molded state of the glass, ion fluence and irradiated volume fraction are systematically varied to rejuvenate the glass, and the resulting plastic behavior of the metallic glass nanowires probed by in situ mechanical testing in a scanning electron microscope. Whereas the as-molded nanowires exhibit high strength, brittle-like fracture and negligible inelastic deformation, ion-irradiated nanowires show tensile ductility and quasi-homogeneous plastic deformation. Signatures of changes to the glass structure owing to ion irradiation as obtained from electron diffraction are subtle, despite relatively large yield strength reductions of hundreds of megapascals relative to the as-molded condition. To reconcile changes in mechanical behavior with glass properties, we adapt previous models equating the released strain energy during shear banding to a transit through the glass transition temperature by incorporating the excess enthalpy associated with distinct structural states. Our model suggests that ion irradiation increases the fictive temperature of our glass by tens of degrees – the equivalent of many orders of magnitude change in cooling rate. We further show our analytical description of yield strength to quantitatively describe literature results showing a correlation between severe plastic deformation and hardness in a single glass system. Our results highlight not only the capacity for room temperature ductile plastic flow in nanoscaled metallic glasses, but also processing strategies capable of glass rejuvenation outside of the realm of traditional thermal treatments

[Lidocaine-containing hyaluronic acid filler on a CPM® basis for lip augmentation : Experience from clinical practice].

Science.gov (United States)

Fischer, T; Sattler, G; Gauglitz, G

2016-06-01

Lip augmentation with hyaluronic acid fillers is an established procedure. As monophasic polydensified hyaluronic acid products with variable density CPM-HAL1 (Belotero® Balance Lidocaine) and CPM-HAL2 (Belotero® Intense Lidocaine) are qualified for beautification and particularly natural-looking rejuvenation, respectively. Assessment of handling and outcome of lip augmentation using the lidocaine-containing hyaluronic acid fillers CPM-HAL1 and CPM-HAL2. Data from patients who received lip augmentation by means of bautification and/or rejuvenation using CPM-HAL1 and/or CPM-HAL2 were documented. Observation period was 4 months, with assessment of natural outcome, evenness, handling, fluidity, distribution, malleability, tolerability, as well as patient satisfaction and pain. In total, 146 patients from 21 German centres participated. Physicians rated natural outcome and evenness as good or very good for > 95 % of patients. Handling, fluidity, distribution and malleability were assessed for both fillers as good or very good in > 91 % of patients. At every evaluation point, more than 93 % of patients were very or very much satisfied with the product. A total of 125 patients (85.6 %) experienced transient injection-related side effects. Pain intensity during the procedure was mild (2.72 ± 1.72 on the 0-10 pain assessment scale) and abated markedly within 30 min (0.42 ± 0.57). Lip augmentation with hyaluronic acid fillers produced a long-term cosmetic result. Due to the lidocaine content, procedural pain was low and transient. Accordingly, a high degree of patient satisfaction was achieved that was maintained throughout the observation period.

Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?

Science.gov (United States)

Harper, Shavonn C; Brack, Andrew; MacDonnell, Scott; Franti, Michael; Olwin, Bradley B; Bailey, Beth A; Rudnicki, Michael A; Houser, Steven R

2016-04-01

This "Controversies in Cardiovascular Research" article evaluates the evidence for and against the hypothesis that the circulating blood level of growth differentiation factor 11 (GDF11) decreases in old age and that restoring normal GDF11 levels in old animals rejuvenates their skeletal muscle and reverses pathological cardiac hypertrophy and cardiac dysfunction. Studies supporting the original GDF11 hypothesis in skeletal and cardiac muscle have not been validated by several independent groups. These new studies have either found no effects of restoring normal GDF11 levels on cardiac structure and function or have shown that increasing GDF11 or its closely related family member growth differentiation factor 8 actually impairs skeletal muscle repair in old animals. One possible explanation for what seems to be mutually exclusive findings is that the original reagent used to measure GDF11 levels also detected many other molecules so that age-dependent changes in GDF11 are still not well known. The more important issue is whether increasing blood [GDF11] repairs old skeletal muscle and reverses age-related cardiac pathologies. There are substantial new and existing data showing that GDF8/11 can exacerbate rather than rejuvenate skeletal muscle injury in old animals. There is also new evidence disputing the idea that there is pathological hypertrophy in old C57bl6 mice and that GDF11 therapy can reverse cardiac pathologies. Finally, high [GDF11] causes reductions in body and heart weight in both young and old animals, suggestive of a cachexia effect. Our conclusion is that elevating blood levels of GDF11 in the aged might cause more harm than good. © 2016 American Heart Association, Inc.

Volume correction in the aging hand: role of dermal fillers

Directory of Open Access Journals (Sweden)

Rivkin AZ

2016-08-01

Full Text Available Alexander Z Rivkin David Geffen/UCLA School of Medicine Los Angeles, CA, USA Abstract: The hands, just like the face, are highly visible parts of the body. They age at a similar rate and demonstrate comparable changes with time, sun damage, and smoking. Loss of volume in the hands exposes underlying tendons, veins, and bony prominences. Rejuvenation of the hands with dermal fillers is a procedure with high patient satisfaction and relatively low risk for complications. This study will review relevant anatomy, injection technique, clinical safety, and efficacy of dermal filler volumization of the aging hand. Keywords: dermal fillers, hands, volumization, hyaluronic acid, calcium hydroxylapatite

Community mobilisation in the 21st century: updating our theory of social change?

Science.gov (United States)

Campbell, Catherine

2014-01-01

The article explores the Freirian theory of social change underpinning health-related community mobilisation in poor and marginalised communities. Highlighting potential shortcomings of its essentialist understandings of power and identity, and linear notions of change, it examines how lessons from the 'new left', and burgeoning global protest movements, can rejuvenate the field given the growing complexity of 21st-century social inequalities. It suggests the need for a pastiche of approaches to accommodate health struggles in different times and places. However, while needing some updating, Freire's profound and actionable understandings of the symbolic and material dimensions of social inequalities remain a powerful starting point for activism.

Workstations as consoles for the CERN-PS complex, setting-up the environment

International Nuclear Information System (INIS)

Antonsanti, P.; Arruat, M.; Bouche, J.M.; Cons, L.; Deloose, Y.; Di Maio, F.

1992-01-01

Within the framework of the rejuvenation project of the CERN control systems, commercial workstations have to replace existing home-designed operator consoles. RISC-based workstations with UNIX, X-window TM and OSF/Motif TM have been introduced for the control of the PS complex. The first versions of general functionalities like synoptic display, program selection and control panels have been implemented and the first large scale application has been realized. This paper describes the different components of the workstation environment for the implementation of the applications. The focus is on the set of tools which have been used, developed or integrated, and on how we plan to make them evolve. (author)

ONLINE BANKING IN THE ROMANIAN BANKING SYSTEM

Directory of Open Access Journals (Sweden)

IMOLA DRIGĂ

2014-12-01

Full Text Available In the world of banking, the development of IT has a huge effect on development of more flexible payments methods and more user-friendly banking services. Recently, modern electronic banking services, internet and mobile banking, have rejuvenated banking transactions. Electronic banking over the Internet is one of the newest e-banking services with several benefits both for banks and for customers. The paper aims to provide an overview of online banking services highlighting various aspects globally as well as in the Romanian banking system. Even if there already are several studies on web banking, this topic still remains a resourceful area for academic research in the next decade.

Cs2Te normal conducting photocathodes in the superconducting rf gun

CERN Document Server

Xiang, R; Buettig, H; Janssen, D; Justus, M; Lehnert, U; Michel, P; Murcek, P; Schamlott, A; Schneider, Ch; Schurig, R; Staufenbiel, F; Teichert, J

2010-01-01

The superconducting radio frequency photoinjector (SRF gun) is one of the latest applications of superconducting rf technology in the accelerator field. Since superconducting photocathodes with high quantum efficiency are yet unavailable, normal conducting cathode material is the main choice for SRF photoinjectors. However, the compatibility between the photocathode and the cavity is one of the challenges for this concept. Recently, a SRF gun with Cs2Te cathode has been successfully operated in Forschungszentrum Dresden-Rossendorf. In this paper, we will present the physical properties of Cs2Te photocathodes in the SC cavity, such as the quantum efficiency, the lifetime, the rejuvenation, the charge saturation, and the dark current.

Therapeutic cloning in the mouse

Science.gov (United States)

Mombaerts, Peter

2003-01-01

Nuclear transfer technology can be applied to produce autologous differentiated cells for therapeutic purposes, a concept termed therapeutic cloning. Countless articles have been published on the ethics and politics of human therapeutic cloning, reflecting the high expectations from this new opportunity for rejuvenation of the aging or diseased body. Yet the research literature on therapeutic cloning, strictly speaking, is comprised of only four articles, all in the mouse. The efficiency of derivation of embryonic stem cell lines via nuclear transfer is remarkably consistent among these reports. However, the efficiency is so low that, in its present form, the concept is unlikely to become widespread in clinical practice. PMID:12949262

Nanoscale chirality in metal and semiconductor nanoparticles.

Science.gov (United States)

Kumar, Jatish; Thomas, K George; Liz-Marzán, Luis M

2016-10-18

The field of chirality has recently seen a rejuvenation due to the observation of chirality in inorganic nanomaterials. The advancements in understanding the origin of nanoscale chirality and the potential applications of chiroptical nanomaterials in the areas of optics, catalysis and biosensing, among others, have opened up new avenues toward new concepts and design of novel materials. In this article, we review the concept of nanoscale chirality in metal nanoclusters and semiconductor quantum dots, then focus on recent experimental and theoretical advances in chiral metal nanoparticles and plasmonic chirality. Selected examples of potential applications and an outlook on the research on chiral nanomaterials are additionally provided.

Light-emitting diodes - Their potential in biomedical applications

Energy Technology Data Exchange (ETDEWEB)

Yeh, Naichia Gary; Wu, Chia-Hao [College of Applied Sciences, MingDao University, 369 Wen-Hua Road, Peetou, Changhua 52345 (China); Cheng, Ta Chih [Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, 1 Hseuh-Fu Rd., Nei-Pu Hsiang, Pingtung 91201 (China)

2010-10-15

The rapid development of high brightness light-emitting diodes (LEDs) makes feasible the use of LEDs, among other light sources (such as laser, intense pulse light and other incoherent light systems), for medical treatment and light therapy. This paper provides a general review on red, green, blue, ultraviolet LED applications in photo rejuvenation and medical treatments of a variety of physical abnormalities, as well as the relief of stress, circadian rhythm disorders, and seasonal affective disorder. The review, concentrated in the papers published after 1990, intends to show that LEDs are well qualified to succeed its more energy demanding counterparts in the named areas and beyond. (author)

Radiofrequency in cosmetic dermatology.

Science.gov (United States)

Beasley, Karen L; Weiss, Robert A

2014-01-01

The demand for noninvasive methods of facial and body rejuvenation has experienced exponential growth over the last decade. There is a particular interest in safe and effective ways to decrease skin laxity and smooth irregular body contours and texture without downtime. These noninvasive treatments are being sought after because less time for recovery means less time lost from work and social endeavors. Radiofrequency (RF) treatments are traditionally titrated to be nonablative and are optimal for those wishing to avoid recovery time. Not only is there minimal recovery but also a high level of safety with aesthetic RF treatments. Copyright © 2014 Elsevier Inc. All rights reserved.

Ancient Wisdom, Applied Knowledge for a Sustainable Future

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Peterson, K.; Philippe, R. Elde; Dardar, T. M. Elde

2017-12-01

Ancient wisdom informs traditional knowledges that guide Indigenous communities on how to interact with the world. These knowledges and the ancient wisdom have been the life-giving forces that have prevented the complete genocide of Indigenous peoples, and is also the wisdom that is rejuvenating ancient ways that will take the world into a future that embraces the seventh generation philosophy.. Western scientists and agency representatives are learning from the work and wisdom of Native Americans. This presentation will share the ways in which the representatives of two Tribes along the coast of Louisiana have been helping to educate and apply their work with Western scientists.

Fat, Stem Cells, and Platelet-Rich Plasma.

Science.gov (United States)

James, Isaac B; Coleman, Sydney R; Rubin, J Peter

2016-07-01

The ideal filler for aesthetic surgery is inexpensive and easy to obtain, natural in appearance and texture, immunologically compatible, and long lasting without risk of infection. By most metrics, autologous fat grafts meet these criteria perfectly. Although facial fat grafting is now a commonly accepted surgical procedure, there has been a wave of activity applying stem cells and platelet-rich plasma (PRP) therapies to aesthetic practice. This article addresses technical considerations in the use of autologous fat transfer for facial rejuvenation, and also explores the current evidence for these stem cell and PRP therapies in aesthetic practice. Copyright © 2016 Elsevier Inc. All rights reserved.

Non-surgical radiofrequency facelift.

Science.gov (United States)

Narins, David J; Narins, Rhoda S

2003-10-01

There has been considerable interest in using non-ablative methods to rejuvenate the skin. The ThermaCool TC (Thermage Inc.) is a radiofrequency (RF) device that has been introduced to induce tightening of the address the problem of skin via a uniform volumetric heating into the deep dermis tightening, resulting in a 'non-surgical facelift'. Radiofrequency produces a uniform volumetric heating into the deep dermis. Twenty treatment areas in 17 patients were treated to evaluate the efficacy and safety of RF treatment to the brow and jowls. The technique was found to produce gradual tightening in most patients, and there were no adverse effects.

Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

Directory of Open Access Journals (Sweden)

Meenakshi Gaur

2017-01-01

Full Text Available Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs communicate with organ systems to adjust immune response, provide signals for differentiation, migration, enzymatic reactions, and to equilibrate the regenerative demands of balanced tissue homeostasis. The identification of the mechanisms by which ADSCs accomplish these functions for dermatological rejuvenation and wound healing has great potential to identify novel targets for the treatment of disorders and combat aging. Herein, we review new insights into the role of adipose-derived stem cells in the maintenance of dermal and epidermal homeostasis, and recent advances in clinical applications of ADSCs related to dermatology.

Water Puppetry in the Red River Delta and Beyond: Tourism and the Commodification of an Ancient Tradition

Directory of Open Access Journals (Sweden)

Sam Pack

2012-05-01

Full Text Available ' ' This article seeks to examine the interplay between the rise and development of the international tourism industry and the production of culture in the performance of Vietnamese water puppetry.  Although tourism has indelibly altered this traditional art form, it is also responsible for the rejuvenation and continued existence of water puppetry.  Rather than simply dismissing contemporary enactments as inauthentic representations, we problematize notions of cultural authenticity.  Indeed, increasing global integration does not simply result in the elimination of cultural diversity but rather provides the context for the production of new cultural forms that are marked by local specificity.

Effects of polarization and absorption on laser induced optical breakdown threshold for skin rejuvenation

Science.gov (United States)

Varghese, Babu; Bonito, Valentina; Turco, Simona; Verhagen, Rieko

2016-03-01

Laser induced optical breakdown (LIOB) is a non-linear absorption process leading to plasma formation at locations where the threshold irradiance for breakdown is surpassed. In this paper we experimentally demonstrate the influence of polarization and absorption on laser induced breakdown threshold in transparent, absorbing and scattering phantoms made from water suspensions of polystyrene microspheres. We demonstrate that radially polarized light yields a lower irradiance threshold for creating optical breakdown compared to linearly polarized light. We also demonstrate that the thermal initiation pathway used for generating seed electrons results in a lower irradiance threshold compared to multiphoton initiation pathway used for optical breakdown.

Systems, not pills: The options market for antibiotics seeks to rejuvenate the antibiotic pipeline.

Science.gov (United States)

Brogan, David M; Mossialos, Elias

2016-02-01

Over the past decade, there has been a growing recognition of the increasing growth of antibiotic resistant bacteria and a relative decline in the production of novel antibacterial therapies. The combination of these two forces poses a potentially grave threat to global health, in both developed and developing countries. Current market forces do not provide appropriate incentives to stimulate new antibiotic development, thus we propose a new incentive mechanism: the Options Market for Antibiotics. This mechanism, modelled on the principle of financial call options, allows payers to buy the right, in early stages of development, to purchase antibiotics at a discounted price if and when they ever make it to market approval. This paper demonstrates the effect of such a model on the expected Net Present Value of a typical antibacterial project. As part of an integrated strategy to confront the impending antibiotic crisis, the Options Market for Antibiotics may effectively stimulate corporate and public investment into antibiotic research and development. Copyright © 2016. Published by Elsevier Ltd.

Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota.

Science.gov (United States)

Xu, Xiaofei; Yang, Jiguo; Ning, Zhengxiang; Zhang, Xuewu

2015-08-01

Aging is characterized by impaired immunity and unbalanced gut microbiota. Prebiotics have the capability to prevent or reverse age-related declines in health by modulating gut microbiota. Mushroom polysaccharides have been suggested to be potential prebiotics. However, their effects on the immunity and gut microbiota in aged mice have not been determined. This study firstly assessed the effects of a heteropolysaccharide L2 isolated from the fruit body of L. edodes on the immune response of aged mice, and then compared the composition of fecal microbiota in adult (N), old (O) and L2-treated old (Oa) mice using the high-throughput pyrosequencing technique. The results showed that L2 can restore the age-attenuated immune responses by increasing cytokine levels in peripheral blood. Moreover, L2 can partly reverse the age-altered composition of gut microbiota. The Euclidean distances (De) among 3 groups (N, O and Oa) are determined to be De(O, N) = 0.19, De(O, Oa) = 0.20, and De(N, Oa) = 0.10, i.e. there is a marked reduction in the distance from 0.19 to 0.1 by L2. This suggests the beneficial effects of L2 on enhancing immunity and improving gut health.

Morella serrata (Lam.) Killick stabilizes biomembrane and rejuvenates sexual competence in male Wistar rats.

Science.gov (United States)

Sabiu, S; Ashafa, A O T

2017-06-09

Morella serrata L. is an indigenous medicinal plant to South and southern Africa with folkloric applications as aphrodisiac, laxative, antimicrobial, anti-inflammatory, analgesic, anti-hypertensive, antitussive and antidiabetic agent. This study evaluated the membrane stabilization and aphrodisiac potentials of its aqueous root extract in male Wistar rats. While the membrane stabilization of the extract was investigated against bovine erythrocytes (BE), the male rats for the aphrodisiac study were randomized into five groups with animals in group 1 given sterile placebo and served as control. The rats in group 2 were treated with 7.14mg/kg body weight of PowMaxM, while animals in groups 3, 4 and 5 were administered with the extract (100, 200 and 400mg/kg, respectively). All treatments (1mL) were done once daily for 4 weeks via oral gavaging and their mating behavioural, testicular, spermatogenetic and antioxidant parameters were evaluated. With the exception of the mount, intromission and post ejaculatory latencies that were dose-dependently reduced by the extract, other mating parameters were significantly improved when compared with the control. Similar patterns of significant improvement were also observed on the testes-body weight ratio, quality and viability of sperm cells as well as testicular concentrations of proteins, cholesterol, glycogen, testosterone, follicle stimulating hormone, leuitenizing hormone and glutathione (reduced) subsequent to treatment with the extract. Although, administration of M. serrata had no significant (p>0.05) effect on the testicular activity of gamma glutamyl transferase, those of lactate dehydrogenase, phosphatases (alkaline and acid), superoxide dismutase and catalase were significantly (p<0.05) induced in the treated animals. The extract also conferred respective significant (p<0.05) membrane stabilization potential of 66.02% and 60.87% on the BE against hypotonic solution and heat-induced hemolysis relative to 62.14% and 40.19% for ibuprofen. The effect elicited by the extract at the tested doses could partly be attributed to its antioxidant and adaptogenic constituents. The data presented in this study have enriched biochemical information on the root extract of M. serrata as a viable source of phytonutrients that could be potentially useful for the development of aphrodisiac drugs, and thus lending scientific credence to its much touted sex enhancing attributes by the Basothos of the eastern Free State Province of South Africa. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Effect of thread embedding acupuncture for facial wrinkles and laxity: a single-arm, prospective, open-label study

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Younghee Yun

2017-12-01

Full Text Available Background: There is a growing trend for patients to seek the least invasive treatments with less risk of complications and downtime for facial rejuvenation. Thread embedding acupuncture has become popular as a minimally invasive treatment. However, there is little clinical evidence in the literature regarding its effects. Methods: This single-arm, prospective, open-label study recruited participants who were women aged 40–59 years, with Glogau photoaging scale III–IV. Fourteen participants received thread embedding acupuncture one time and were measured before and after 1 week from the procedure. The primary outcome was a jowl to subnasale vertical distance. The secondary outcomes were facial wrinkle distances, global esthetic improvement scale, Alexiades–Armenakas laxity scale, and patient-oriented self-assessment scale. Results: Fourteen participants underwent thread embedding acupuncture alone, and 12 participants revisited for follow-up outcome measures. For the primary outcome measure, both jowls were elevated in vertical height by 1.87 mm (left and 1.43 mm (right. Distances of both melolabial and nasolabial folds showed significant improvement. In the Alexiades–Armenakas laxity scale, each evaluator evaluated for four and nine participants by 0.5 grades improved. In the global aesthetic improvement scale, improvement was graded as 1 and 2 in nine and five cases, respectively. The most common adverse events were mild bruising, swelling, and pain. However, adverse events occurred, although mostly minor and of short duration. Conclusion: In this study, thread embedding acupuncture showed clinical potential for facial wrinkles and laxity. However, further large-scale trials with a controlled design and objective measurements are needed. Keywords: polydioxanone, rejuvenation, rhytidoplasty, skin aging, thread embedding acupuncture

Mid-Face Volumization With Hyaluronic Acid: Injection Technique and Safety Aspects from a Controlled, Randomized, Double-Blind Clinical Study.

Science.gov (United States)

Prager, Welf; Agsten, Karla; Kravtsov, Maria; Kerscher, Prof Martina

2017-04-01

BACKGROUND: Injection of hyaluronic acid (HA) volumizing fillers in the malar area is intended for rejuvenation of the mid-face. The choice of products, depth, and technique of injection depends on the desired level of volume enhancement and practitioners' preferences. OBJECTIVE: To describe a volumizing injection technique in the scope of a controlled, randomized, double-blind, single-center, split-face clinical study. A total of 45 subjects with bilateral symmetrical moderate to severe volume loss in the malar area received a single 2 mL injection of CPM®-26 (Cohesive Polydensified Matrix®) on one side and VYC®-20 (VYCROSS®) on the contralateral side of the face. The same injection technique was applied for both sides of the face. Use of anesthetics, overcorrection, and touch-ups were not permitted. The investigator completed a product satisfaction questionnaire. Adverse events (AE) and injection-site reactions (ISRs) were reported during the study. RESULTS: The products were placed at the epiperiosteal depth in 88.9% (n=40), at the subdermal depth in 8.9% (n=4) and at both levels in 2.2% (n=1) of subjects. Fanning technique using cannulae was applied in most cases (97.8%, n=44). Results of the investigator satisfaction questionnaire allowed to characterize CPM-26 in comparison to other volumizing gels. Both study products were generally well tolerated. Local reactions were transient and of mild to moderate intensity, with the most frequent ones being redness, pain, and swelling. CONCLUSION: Adequate injection technique in volumizing treatments is essential to create a natural aesthetic rejuvenation while respecting the safety aspect of the procedures. A 22G blunt cannula used with CPM-26 was preferred due to an easier and a more homogeneous distribution of the product. The investigator also appreciated CPM-26 for its ease of injection, positioning, lifting, and volumizing capacity. J Drugs Dermatol. 2017;16(4):351-357..

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Directory of Open Access Journals (Sweden)

Crisan D

2015-09-01

Full Text Available Diana Crisan,1 Iulia Roman,2 Maria Crisan,2 Karin Scharffetter-Kochanek,1 Radu Badea31Clinic of Dermatology and Allergology, University Clinic Ulm, Ulm, Germany; 2Clinic of Dermatology and Venereology, 3Department of Clinical Imaging Ultrasound, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaBackground: Imagistic methods stand as modern, non-invasive, and objective means of assessing the impact of topical cutaneous therapies.Objective: This study focuses on the evaluation, by high-frequency ultrasound, of the cutaneous changes induced by topical use of a vitamin C complex at facial level.Methods: A vitamin C-based solution/Placebo moisturizer cream was applied at facial level of 60 healthy female subjects according to a predetermined protocol. Ultrasonographic images (Dermascan C, 20 MHz were taken from zygomatic level initially, at 40 and 60 days after therapy. The following parameters were assessed for every subject: thickness of the epidermis and dermis (mm, the number of low (LEP, medium (MEP, high echogenic pixels (HEP, and the number of LEP in the upper dermis/lower dermis (LEPs/LEPi.Results: LEP decreased significantly in all age categories during and after therapy, but especially in the first 2 age intervals, up to the age of 50 (P=0.0001. MEP and HEP, pixel categories that quantify protein synthesis also had an age-dependent evolution in the study, increasing significantly in all age categories but most of all in the first age interval (P=0.002. Our ultrasonographic data suggest that collagen synthesis increased significantly after topical vitamin C therapy, and is responsible for the increase in MEP and HEP and consequent decrease of the LEP.Conclusion: Our study shows that topically applied vitamin C is highly efficient as a rejuvenation therapy, inducing significant collagen synthesis in all age groups with minimal side effects.Keywords: ascorbic acid, rejuvenation, ultrasound, collagen synthesis

Strategi Peningkatan Penerimaan Pajak Bumi dan Bangunan (PBB : Studi Kasus di Kabupaten Klaten

Directory of Open Access Journals (Sweden)

Pratiwi DK

2015-12-01

Full Text Available In order to get regional development fund in local government, it was done many ways to increase local income both from local revenue or out local revenue, one of income source that potentially increased is Land and Building Tax (hereafter called PBB. So that, there should be certain strategies that could increase the income of PBB in localgovernment This paper deals strategic management approach to indentii, strategic factors, strategic issues and strategies that could be developed to increase the income of PBB. Thispaperis result of case study research in local government of Klaten. The result of strategic environment analysis (SWOTfor Revenue Office in local government of Klaten , it was identified 28 factor that influence the income of PBB, including 7 Strength , 6 Weaknesses, 9 Opportunities, and 6 Threats. From the analysis of both internal and external factors and after the litmus test and the evaluation of PEST aspect, it could be identfied4 most strategic issues in increasing the income of PBB in localgovernment of Klaten , there are the increasing valuation of object of PBB( hereafter talledNJOP, increasing the PBB intensification, PBB computerized and Data rejuvenation . The recommended strategies for increasing the income of PBB in local government of .Klaten are :for responding the NJOP increasing issue, it recommended the strategy of evaluating, review, adjust the old ITT, and determine a new NJOP of NJOP of PBB, the strategy for responding data rejuvenation issue is optimized the registry, data collection and valuation of subject and object of PBB,. for responding the issue of increasing PBB intensification, the recommended strategy is optimizing PBB intensification, increase people and government awareness and closes the service and the recommeded strategyforreVodingPBB computerized issue is increasing and perfection a gstim of PBB computerized.

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system.

Science.gov (United States)

Rawji, Khalil S; Mishra, Manoj K; Michaels, Nathan J; Rivest, Serge; Stys, Peter K; Yong, V Wee

2016-03-01

Ageing of the central nervous system results in a loss of both grey and white matter, leading to cognitive decline. Additional injury to both the grey and white matter is documented in many neurological disorders with ageing, including Alzheimer's disease, traumatic brain and spinal cord injury, stroke, and multiple sclerosis. Accompanying neuronal and glial damage is an inflammatory response consisting of activated macrophages and microglia, innate immune cells demonstrated to be both beneficial and detrimental in neurological repair. This article will propose the following: (i) infiltrating macrophages age differently from central nervous system-intrinsic microglia; (ii) several mechanisms underlie the differential ageing process of these two distinct cell types; and (iii) therapeutic strategies that selectively target these diverse mechanisms may rejuvenate macrophages and microglia for repair in the ageing central nervous system. Most responses of macrophages are diminished with senescence, but activated microglia increase their expression of pro-inflammatory cytokines while diminishing chemotactic and phagocytic activities. The senescence of macrophages and microglia has a negative impact on several neurological diseases, and the mechanisms underlying their age-dependent phenotypic changes vary from extrinsic microenvironmental changes to intrinsic changes in genomic integrity. We discuss the negative effects of age on neurological diseases, examine the response of senescent macrophages and microglia in these conditions, and propose a theoretical framework of therapeutic strategies that target the different mechanisms contributing to the ageing phenotype in these two distinct cell types. Rejuvenation of ageing macrophage/microglia may preserve neurological integrity and promote regeneration in the ageing central nervous system. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions

Hyaluron Filler Containing Lidocaine on a CPM Basis for Lip Augmentation: Reports from Practical Experience.

Science.gov (United States)

Fischer, Tanja C; Sattler, Gerhard; Gauglitz, Gerd G

2016-06-01

Lip augmentation with hyaluronic acid fillers is established. As monophasic polydensified hyaluronic acid products with variable density, CPM-HAL1 (Belotero Balance Lidocaine, Merz Aesthetics, Raleigh, NC) and CPM-HAL2 (Belotero Intense Lidocaine, Merz Aesthetics, Raleigh, NC) are qualified for beautification and particularly natural-looking rejuvenation, respectively. The aim of this article was to assess the handling and outcome of lip augmentation using the lidocaine-containing hyaluronic acid fillers, CPM-HAL1 and CPM-HAL2. Data were documented from patients who received lip augmentation by means of beautification and/or rejuvenation using CPM-HAL1 and/or CPM-HAL2. Observation period was 4 months, with assessment of natural outcome, evenness, distribution, fluidity, handling, malleability, tolerability, as well as patient satisfaction and pain. A total of 146 patients from 21 German centers participated. Physicians rated natural outcome and evenness as good or very good for more than 95% of patients. Distribution, fluidity, handling, and malleability were assessed for both fillers as good or very good in more than 91% of patients. At every evaluation point, more than 93% of patients were very or very much satisfied with the product. A total of 125 patients (85.6%) experienced transient injection-related side effects. Pain intensity during the procedure was mild (2.72 ± 1.72 on the 0-10 pain assessment scale) and abated markedly within 30 minutes (0.42 ± 0.57). Lip augmentation with hyaluronic acid fillers produced a long-term cosmetic result. Due to the lidocaine content, procedural pain was low and transient. Accordingly, a high degree of patient satisfaction was achieved that was maintained throughout the observation period. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Review of thorium fuel reprocessing experience

International Nuclear Information System (INIS)

Brooksbank, R.E.; McDuffee, W.T.; Rainey, R.H.

1978-01-01

The review reveals that experience in the reprocessing of irradiated thorium materials is limited. Plants that have processed thorium-based fuels were not optimized for the operations. Previous demonstrations of several viable flowsheets provide a sound technological base for the development of optimum reprocessing methods and facilities. In addition to the resource benefit by using thorium, recent nonproliferation thrusts have rejuvenated an interest in thorium reprocessing. Extensive radiation is generated as the result of 232 U-contamination produced in the 233 U, resulting in the remote operation and fabrication operations and increased fuel cycle costs. Development of the denatured thorium flowsheet, which is currently of interest because of nonproliferation concerns, represents a difficult technological challenge

Filling the Midface: Injectables.

Science.gov (United States)

Winslow, Catherine

2016-10-01

Volumizing the face has become commonplace on the facial aesthetic scene, with a rapid explosion of popularity in the field of nonsurgical rejuvenation. Three-dimensional enhancement of the midface with fillers provides the surgeon with a minimal downtime opportunity to treat early aging or reverse nonsurgical volume loss. With new products come advancements in techniques and the understanding of reversal of the effects of aging. While providing minimal downtime and risk, complications can occur and the physician must be able to recognize and treat these issues. It is crucial for the injector to understand and process these factors to ensure patient satisfaction and safety. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Mesotherapy, Microneedling, and Chemical Peels.

Science.gov (United States)

Lee, Johnson C; Daniels, Mark A; Roth, Malcolm Z

2016-07-01

Mesotherapy, microneedling, and chemical peels are minimally invasive techniques used to combat facial aging. Chemical peeling is one of the oldest methods of facial rejuvenation. By using different chemicals in various combinations, strengths, and application techniques, plastic surgeons can tailor a patient's treatment for optimal, safe, and consistent results. Mesotherapy and microneedling have emerged in the plastic surgery literature with increasingly complex indications. Both techniques have increased in popularity although research into efficacy and long-term results is lagging. With a thorough understanding of patients and the modalities available, plastic surgeons can use the appropriate minimally invasive technique to provide patients with desired skin changes. Copyright © 2016 Elsevier Inc. All rights reserved.

Precambrian uranium deposits as a possible source of uranium for the European Variscan deposits

International Nuclear Information System (INIS)

Mineeva, I.G.; Klochkov, A.S.

2002-01-01

The Precambrian uranium deposits have been studied on the territory of Baltic and Ukrainian shields. The primary Early Proterozoic complex Au-U deposits originated in granite-greenstone belts as a result of their evolution during continental earth crust formation by prolonged rift genesis. The greenstone belts are clues for revealing ancient protoriftogenic structures. The general regularities of uranium deposition on Precambrian shields are also traceable in Variscan uranium deposits from the Bohemian massif. The Variscan period of uranium ore formation is connected with a polychronous rejuvenation of ancient riftogenous systems and relatively younger processes of oil and gas formation leading to the repeated mobilization of U from destroyed Proterozoic and Riphean uranium deposits. (author)

Multiscale assessment of micro-seismicity and slow earthquakes

Science.gov (United States)

Yuen, David A.; Ni, Sidao; Wang, Yibo; Xu, Chang; Veveakis, Manny

2017-03-01

Today we witness the economical throes and uncertainties created by the dramatic cratering of oil prices in 2014 from 115 dollars per barrel to 38 dollars. This dramatic nonlinear phenomenon reminds earth scientists of the disintegration of the Laurentide ice sheet, some 14,000 years ago. One of the contributing factors of the precipitous drop in oil prices is super-fracking. This is used for oil as well as for gas production and became economically feasible about .twenty years ago. Thanks to this technological breakthrough Americans had enjoyed a renaissance in oil production since 2005. This process, however, has some drawbacks, such as the induced earthquakes occurring in rejuvenated or new fields (Fig. 1).

Forward to the Special Issue in Physics of the Earth and Planetary Interiors on Multiscale Assessment of Micro-Seismicity and Slow Earthquakes

Science.gov (United States)

Yuen, David A.; Ni, Sidao; Wang, Yibo; Xu, Chang; Veveakis, Manny

2016-12-01

Today we witness the economical throes and uncertainties created by the dramatic cratering of oil prices in 2014 from 115 dollars per barrel to 38 dollars. This dramatic nonlinear phenomenon reminds earth scientists of the disintegration of the Laurentide ice sheet, some 14,000 years ago. One of the contributing factors of the precipitous drop in oil prices is super-fracking. This is used for oil as well as for gas production and became economically feasible about .twenty years ago. Thanks to this technological breakthrough Americans had enjoyed a renaissance in oil production since 2005. This process, however, has some drawbacks, such as the induced earthquakes occurring in rejuvenated or new fields (Fig. 1).

The mutagenesis and breeding of high productive strains of streptomyces jingyangensis '5406'

International Nuclear Information System (INIS)

Qi Hongyan; Yin Xinyun

1988-03-01

The purpose of these experiments is to explore the mutagenesis rhythm and breed high productive strains of actinomycete '5406'. The single colony agar pieces of strain F 358 were treated with fast neutron and 60 Co-γ ray irradiation Two mutants have been selected from 20025 treated single colonies. The output of cytokinins from them is higher than from strain F 358 . The original strain 'Mu-Tan-al' rejuvenated by freezing was treated with several physical and chemical mutagens. The mutagenesis rhythm has been summed up tentatively. Eight mutants obtained from 93014 treated single colonies produced more '5406' antibiotics than that of strain 'Mu-Tan-al,. The effect of mutant 'N2-10-Ra3' was the best

Postponing aging and prolonging life expectancy with the knowledge-based economy.

Science.gov (United States)

Kristjuhan, Ulo

2012-04-01

People are interested in the aging phenomenon and hope that scientists are doing as much as they can to solve the mysteries of aging. However, this is not the case. A lot of knowledge is produced for local interests in curing specific disorders; aging is studied much less. Today's economy is undergoing a transition to a knowledge-based economy. Knowledge of aging should be integrated into the economies of contemporary societies. Aging research and intervention can ensure better health, primarily among middle-aged and older people, and prolong life. There are many reasons why postponing aging and rejuvenation research is not as widespread as it should be. Developed countries should create economic stimuli for such studies and intervention.

Case histories of intense pulsed light phototherapy in dermatology - the HPPL™ and IFL™ technologies

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Alessandro Martella

2017-06-01

Full Text Available The intense pulsed light (IPL and laser technologies are widely used for skin rejuvenation and for treating several dermatological disorders such as skin dyschromia and acne, and for non-ablative dermal remodeling of rhytides and hypertrophic scars. Technological evolution is rapid. The High Power Pulsed Light™ [HPPL™] and Incoherent Fast Light™ technologies [IFL™, Novavision Group S.p.A., 20826 Misinto (MB, Italy] are recent innovations in the field of IPL technologies; IFL™ is a further evolution of the already advanced HPPL™ system. The paper presents a selection of case histories of dermatological lesions treated with the HPPL™ and IFL™ technologies. All study materials were appropriately peer-reviewed for ethical problems.

Physics activities

International Nuclear Information System (INIS)

1997-09-01

As we move into the 21st Century, nuclear technology is on the verge of rejuvenation in advanced Member States and of expansion in developing Member States. The principal responsibilities of the IAEA are transferring technologies, co-ordinating scientific research, managing specialized projects and maintaining analytical quality control. The IAEA physics activities provide assistance with nuclear instrumentation, promote more effective utilization of research reactors and accelerators, and facilitate global co-operation in nuclear fusion research. These activities will help Member States improve their standards of living through the benefits of nuclear technology. This booklet presents a brief profile on the physics activities and involvement in these fields of the Physics Section, IAEA

Cs_{2}Te normal conducting photocathodes in the superconducting rf gun

Directory of Open Access Journals (Sweden)

R. Xiang

2010-04-01

Full Text Available The superconducting radio frequency photoinjector (SRF gun is one of the latest applications of superconducting rf technology in the accelerator field. Since superconducting photocathodes with high quantum efficiency are yet unavailable, normal conducting cathode material is the main choice for SRF photoinjectors. However, the compatibility between the photocathode and the cavity is one of the challenges for this concept. Recently, a SRF gun with Cs_{2}Te cathode has been successfully operated in Forschungszentrum Dresden-Rossendorf. In this paper, we will present the physical properties of Cs_{2}Te photocathodes in the SC cavity, such as the quantum efficiency, the lifetime, the rejuvenation, the charge saturation, and the dark current.

The Changing Treatment Landscape for Metastatic Urothelial Carcinoma.

Science.gov (United States)

Flaig, Thomas W

2018-05-01

Urothelial carcinoma is the predominant histologic type of bladder cancer. After 30 years of minimal progress in the treatment of advanced-stage disease, recent advances in the genomic characterization of urothelial cancer and breakthroughs in bladder cancer therapeutics have rejuvenated the field. Nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab are among the exciting recent novel therapeutic advances gaining approvals by the FDA for treatment of advanced-stage urothelial carcinoma. Yet the challenge for clinicians is to determine the optimal choice of agents as first-line or second-line therapy and which offers the best chance for overall survival for the individual patient in this rapidly changing field. Copyright © 2018 by the National Comprehensive Cancer Network.

Scintillation activity in an unirradiated single crystal of 3-hydroxyxanthine

International Nuclear Information System (INIS)

Cooke, D.W.; Jahan, M.S.; Alexander, C. Jr.

1976-01-01

A method of growing single crystals (approximately 4mm long) of 3-hydroxyxanthine is described. Observed scintillations occurring in an unirradiated single crystal of this potent oncogen as the temperature is lowered from 300 to 90 K are shown. It was found that these scintillations occur upon heating or cooling and do not diminish in activity as the number of heating and cooling cycles increase. It was found that a short duration u.v. exposure would terminate the scintillation activity and various attempts (such as annealing and pressure changes) to rejuvenate them were unsuccessful. With these observations in mind speculation is made concerning the mechanisms associated with the production of purine N-oxide derivatives. (U.K.)

Fission track and petrostructural analysis of carbonatic massif of Tamazert ( high central Atlas, Morocco) and neogene reactivation of the north-atlasic fault

International Nuclear Information System (INIS)

Ziad, N.; Khazrouni, S.; Tayebi, M.; Bouabdli, A.; Poupeau, G.

2001-01-01

The uranium fission-track dating method is used in geochronological survey of basic apatites extracted from the Tamazert complex. The result of this survey coupled with those of petrostructural analysis of this massif enabled as to distinguish three age groups: 32.4 Myr, 23.3 Myr and 12.6 Myr. The first age corresponds to the setting up of the massif, whereas the two other ages indicate later emissions. The setting up of the sill whose age is 12.6 Myr induced a partial rejuvenation of the emission age og the massif. This late volcanic emission is probably related to the north-atlasic fault activity. 4 figs., 1 tab., 30 refs. (au)

Leveraging organisational cultural capital

Directory of Open Access Journals (Sweden)

R Scheel

2007-10-01

Full Text Available Organisational culture discourse mandates a linear approach of diagnosis, measurement and gap analysis as standard practice in relation to most culture change initiatives. Therefore, a problem solving framework geared toward “fixing�? and/or realigning an organisation’s culture is usually prescribed. The traditional problem solving model seeks to identify gaps between current and desired organisational cultural states, inhibiting the discovery of an organisation’s unique values and strengths, namely its cultural capital. In pursuit of discovering and leveraging organisational cultural capital, a descriptive case study is used to show how an Appreciative Inquiry process can rejuvenate the spirit of an organisation as a system-wide inquiry mobilises a workforce toward a shared vision.

Current research in aging: a report from the 2015 Ageing Summit.

Science.gov (United States)

Moyse, Emmanuel; Lahousse, Lies; Krantic, Slavica

2015-01-01

Ageing Summit, London, UK, 10-12 February 2015 The Ageing Summit 2015 held on 10-12 February 2015 in London (UK) provided an extensive update to our knowledge of the 'Biology of Ageing' and a forum to discuss the participants' latest research progress. The meeting was subdivided into four thematic sessions: cellular level research including the aging brain; slowing down progression, rejuvenation and self-repair; genetic and epigenetic regulation; and expression and pathology of age-related diseases. Each session included multiple key presentations, three to five short research communications and ongoing poster presentations. The meeting provided an exciting multidisciplinary overview of the aging process from cellular and molecular mechanisms to medico-social aspects of human aging.

The role of lasers and intense pulsed light technology in dermatology

Science.gov (United States)

Husain, Zain; Alster, Tina S

2016-01-01

The role of light-based technologies in dermatology has expanded dramatically in recent years. Lasers and intense pulsed light have been used to safely and effectively treat a diverse array of cutaneous conditions, including vascular and pigmented lesions, tattoos, scars, and undesired hair, while also providing extensive therapeutic options for cosmetic rejuvenation and other dermatologic conditions. Dermatologic laser procedures are becoming increasingly popular worldwide, and demand for them has fueled new innovations and clinical applications. These systems continue to evolve and provide enhanced therapeutic outcomes with improved safety profiles. This review highlights the important roles and varied clinical applications that lasers and intense pulsed light play in the dermatologic practice. PMID:26893574

Hair restoration.

Science.gov (United States)

Rawnsley, Jeffrey D

2008-08-01

The impact of male hair loss as a personal and social marker of aging is tremendous and its persistence as a human concern throughout recorded history places it in the forefront of male concern about the physical signs of aging. Restoration of the frontal hairline has the visual effect of re-establishing facial symmetry and turning back time. Follicular unit transplantation has revolutionized hair restoration, with its focus on redistributing large numbers of genetically stable hair to balding scalp in a natural distribution. Follicular unit hair restoration surgery is a powerful tool for the facial plastic surgeon in male aesthetic facial rejuvenation because it offers high-impact, natural-appearing results with minimal downtime and risk for adverse outcome.

Pulsed laser light forces cancer cells to absorb anticancer drugs--the role of water in nanomedicine.

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Sommer, Andrei P; Zhu, Dan; Mester, Adam R; Försterling, Horst-Dieter

2011-06-01

Anticancer drugs executing their function intracellularly enter cancer cells via diffusive processes. Complementary to these slow processes, cells can be forced to incorporate drugs by convection - a more efficient transport process. Transmembrane convection is induced by moderately intense pulsed laser light (or light emitting diodes) changing the structure of nanoscopic water layers in cells. This is a fundamental difference with the method of photodynamic therapy. In a model system we demonstrate that a total irradiation time of one minute is sufficient to completely inhibit proliferation of cancer cells. Transmembrane convection protects healthy cells from extended chemotherapy exposure, could be exploited to overcome multidrug resistance, and is a promising new tool in a variety of therapies as well as in skin rejuvenation.

Use of dermal fat graft for augmentation of the labia majora.

Science.gov (United States)

Salgado, Christopher J; Tang, Jennifer C; Desrosiers, Arthur E

2012-02-01

Dermal fat grafts have been utilized in plastic surgery for both reconstructive and aesthetic purposes of the face, breast, and body. There are multiple reports in the literature on the male phallus augmentation with the use of dermal fat grafts. Few reports describe female genitalia aesthetic surgery, in particular rejuvenation of the labia majora. In this report we describe an indication and use of autologous dermal fat graft for labia majora augmentation in a patient with loss of tone and volume in the labia majora. We found that this procedure is an option for labia majora augmentation and provides a stable result in volume-restoration. Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Empirical Study Utilizing QFD to Develop an International Marketing Strategy

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Cassandra Elrod

2015-08-01

Full Text Available Customer expectations can be extremely nebulous. This research identifies the demographic segmentations and their respective expectations for the spa market. Interviews were conducted and a subsequent questionnaire was employed to gather the voice of the customer and assess the expectations of spa clientele. All of the data was collected from luxury spas in Hawaii, and consisted of respondents from all over the world. Results of the survey suggest that while men want more tangible benefits of a spa, women prefer the experiential qualities of peace and rejuvenation. Additionally, those of lower to middle income focus on the atmosphere more than wealthier clients, who are looking for more long term spa benefits, such as a more youthful appearance.

Naturin: a potent bio-immunomodifier

International Nuclear Information System (INIS)

Rong Nian Shen; Li Lu; Homayoon Shidnia; Xiao Qing Jia

1995-01-01

Mechanism of the efficacy of naturin in enhancement and rejuvenation in natural immunity including NK cells, LAK cell activity and CD4 + T-cell function against cancer and infectious diseases is still not known. However, the immunomodulating effect of naturin is similar or even better than the results of IL-1α and IL-7. It is intriguing to speculate that the potent immunomodifier effect of naturin may be mediated either entirely or partially due to a mechanism involving cytokines. Our experiments suggest that naturin plays a role in the restoration of cellular immunosuppression induced by a number of different stresses. This in turn may reflect the fact that naturin possesses a potential regulatory role in induction of some immune cytokines. 31 refs., 4 figs., 4 tabs

Kleinian groups and uniformization in examples and problems

CERN Document Server

Krushkal′, S L

1986-01-01

Aimed at researchers, graduate students and undergraduates alike, this book presents a unified exposition of all the main areas and methods of the theory of Kleinian groups and the theory of uniformization of manifolds. The past 20 years have seen a rejuvenation of the field, due to the development of powerful new methods in topology, the theory of functions of several complex variables, and the theory of quasiconformal mappings. Thus this new book should provide a valuable resource, listing the basic facts regarding Kleinian groups and serving as a general guide to the primary literature, particularly the Russian literature in the field. In addition, the book includes a large number of examples, problems, and unsolved problems, many of them presented for the first time.

Stretching Out Life, Maintaining the Body: Part I - Vayas in Medical Literature

Directory of Open Access Journals (Sweden)

Christèle Barois

2017-12-01

Full Text Available The representation of the process of human life is at the heart of questions about longevity, rejuvenation practices and possibly those which aim at immortality. The key term for “age” in medieval India is vayas, which means “vigour”, “youth” or even  “any period of life”, that is to say  exactly the same meaning as ours (duration of life. As a criterion for the examination of the patient, vayas is invariably divided into three periods: childhood, intermediate age and old age, precisely defined in the ayurvedic saṃhitās. It seems that vayas might be a relevant gateway to the cross-disciplinary understandings of age in medieval India, and therefore to the conditions of its (relative mastery.

Comment on “Large-scale bedforms along a tideless outer shelf setting in the western Mediterranean” by Lo Iacono et al. (2010) in Continental Shelf Research vol 30, pp. 1802-1813

Science.gov (United States)

Flemming, B. W.

2013-01-01

Lo Iacono et al. (2010) report the discovery of large (but degraded) subaqueous dunes on the outer continental shelf NE of Valencia, western Mediterranean Sea. They argue that the dunes, after having been generated sometime in the past, are being episodically rejuvenated by high-energy flow events to the present day. Because the height vs. wavelength relation of the dunes falls below the global mean trend predicted by the equation of Flemming (1988), they claim to have discovered a new, low-amplitude type of flow-transverse bedform which typically occurs on microtidal current-swept outer continental shelves. A close inspection of the evidence shows that the reasoning of Lo Iacono et al. (2010) is flawed and that their interpretations and conclusions are premature and unjustified.

The PLA and Chinas Rejuvenation: National Security and Military Strategies, Deterrence Concepts, and Combat Capabilities

Science.gov (United States)

2016-01-01

to envi- ronmental rehabilitation. Policies have been directed to clean the country’s water, air, and soil, all of which remain heavily contaminated ...quality and safety of food and products. However, as with many policies, implementation remains problematic.14 Recent Developments Under Xi...Southeast Asian nations’ military bases, includ- ing those of Thailand, the Philippines, Singapore, Malaysia , and Indonesia. Japan is also men- tioned

Lift-and-fill face lift: integrating the fat compartments.

Science.gov (United States)

Rohrich, Rod J; Ghavami, Ashkan; Constantine, Fadi C; Unger, Jacob; Mojallal, Ali

2014-06-01

Recent discovery of the numerous fat compartments of the face has improved our ability to more precisely restore facial volume while rejuvenating it through differential superficial musculoaponeurotic system treatment. Incorporation of selective fat compartment volume restoration along with superficial musculoaponeurotic system manipulation allows for improved control in recontouring while addressing one of the key problems in facial aging, namely, volume deflation. This theory was evaluated by assessing the contour changes from simultaneous face "lifting" and "filling" through fat compartment-guided facial fat transfer. A review of 100 face-lift patients was performed. All patients had an individualized component face lift with fat grafting to the nasolabial fold, deep malar, and high/lateral malar fat compartment locations. Photographic analysis using a computer program was conducted on oblique facial views preoperatively and postoperatively, to obtain the most projected malar contour point. Two independent observers visually evaluated the malar prominence and nasolabial fold improvements based on standardized photographs. Nasolabial fold improved by at least one grade in 81 percent and by over one grade in 11 percent. Malar prominence average projection increase was 13.47 percent and the average amount of lift was 12.24 percent. The malar prominence score improved by at least one grade in 62 percent of the patients postoperatively, and 9 percent had a greater than one grade improvement. Twenty-eight percent of the patients had a convex malar prominence postoperatively compared with 6 percent preoperatively. Malar prominence improved by at least one grade in 63 percent and by over one grade in 10 percent. The lift-and-fill face lift merges two key concepts in facial rejuvenation: (1) effective tissue manipulation by means of lifting and tightening in differential vectors according to original facial asymmetry and shape; and (2) selective fat compartment filling

CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells.

Science.gov (United States)

Li, Qun; Zhu, Zhangzhang; Wang, Chengde; Cai, Lin; Lu, Jianglong; Wang, Yongchun; Xu, Jiadong; Su, Zhipeng; Zheng, Weiming; Chen, Xianbin

2018-08-01

Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals and society. Mesenchymal stem cell (MSC) therapy is a promising approach for ischemic brain injury. However, MSC treatment potential is progressively reduced with age, limiting their therapeutic efficacy for brain repair post‑stroke. C1q and tumor necrosis factor‑related protein 9 (CTRP9) is a novel cytoprotective cytokine with antioxidant effects, which is highly expressed in brain tissue. The present study tested the hypothesis that CTRP9 might act as an antisenescence factor to promote the rejuvenation of aged MSCs. MSCs were isolated from the bone marrow of young (8‑weeks‑old) and aged (18‑months‑old) male C57BL/6 mice. Cell proliferation was measured by Cell Counting Kit‑8 assay and cell viability was determined by MTT assay. Gene expression levels of interleukin (IL)‑6 and IL‑10 were evaluated with reverse transcription‑quantitative polymerase chain reaction, and secretion of vascular endothelial growth factor, basic fibroblast growth factor, hepatocyte growth factor, and insulin‑like growth factor were measured by ELISA. The expression levels of proteins in the peroxisome proliferator‑activated receptor γcoactivator (PGC)‑1α/AMP‑activated protein kinase (AMPK) signaling pathway were investigated with western blotting. Oxidative stress was evaluated by detecting mitochondrial membrane potential, reactive oxygen species, superoxide dismutase activity and malondialdehyde. MSCs isolated from aged mice exhibited reduced proliferation and viability, and impaired immunoregulatory and paracrine abilities, compared with MSCs from younger mice. CTRP9 had a significant antisenescence effect in aged MSCs by activating PGC‑1α/AMPK signaling and decreasing the oxidative response. Silencing either PGC‑1α or AMPK abolished the above effects of CTRP9. These results suggest that CTRP9 may have a critical role in

Tectonic and lithological controls on fluvial landscape development in central-eastern Portugal: Insights from long profile tributary stream analyses

Science.gov (United States)

Martins, António A.; Cabral, João; Cunha, Pedro P.; Stokes, Martin; Borges, José; Caldeira, Bento; Martins, A. Cardoso

2017-01-01

This study examines the long profiles of tributaries of the Tagus and Zêzere rivers in Portugal (West Iberia) in order to provide new insights into patterns, timing, and controls on drainage development during the Quaternary incision stage. The studied streams are incised into a relict culminant fluvial surface, abandoned at the beginning of the incision stage. The streams flow through a landscape with bedrock variations in lithology (mainly granites and metasediments) and faulted blocks with distinct uplift rates. The long profiles of the analyzed streams record an older transitory knickpoint/knickzone separating (1) an upstream relict graded profile, with lower steepness and higher concavity, that reflects a long period of quasi-equilibrium conditions reached after the beginning of the incision stage, and (2) a downstream rejuvenated long profile, with steeper gradient and lower concavity, particularly for the final reach, which is often convex. The rejuvenated reaches testify to the upstream propagation of several incision waves, interpreted as the response of each stream to increasing crustal uplift and prolonged periods of base-level lowering by the trunk drainages, coeval with low sea level conditions. The morphological configurations of the long profiles enabled spatial and relative temporal patterns of incisions to be quantified. The incision values of streams flowing on the Portuguese Central Range (PCR; ca. 380-150 m) are variable but generally higher than the incision values of streams flowing on the adjacent South Portugal Planation Surface (SPPS; ca. 220-110 m), corroborating differential uplift of the PCR relative to the SPPS. Owing to the fact that the relict graded profiles can be correlated with the Tagus River T1 terrace (1.1-0.9 My) present in the study area, incision rates can be estimated (1) for the streams located in the PCR, 0.38-0.15 m/ky and (2) for the streams flowing on the SPPS, 0.22-0.12 m/ky. The differential uplift inferred in the

Bipolar radiofrequency in the treatment of dermatologic imperfections: clinicopathological and immunohistochemical aspects.

Science.gov (United States)

Montesi, Gianni; Calvieri, Stefano; Balzani, Alberto; Gold, Michael H

2007-09-01

Rapid progress in the technology for skin rejuvenation has allowed for shorter post-treatment times than ever before. An example of such technology is the radiofrequency (RF) device, which offers nonablative skin rejuvenation, particularly for skin tightening and wrinkle reduction. Medical devices that emit RF energy produce a change in the electrical charges of the treated skin creating an electron movement, and the resistance of the tissue to the electron movement generates heat. This article examines the mechanism of action of a new bipolar RF device, which emits RF energy through a handpiece with a bipolar electrode configuration, and assesses the clinical histological and immunohistochemical results on a sample group of patients who underwent a cycle of sessions with this device. Thirty patients affected with periocular wrinkles, glabellar wrinkles, slackness of the cheeks with accentuation of the nasogenian furrow, striae distensae at the scapulohumeral joint, abdomen, and gluteal-trochanteric areas, or acne scars were included. These patients underwent a cycle of 6 to 8 sessions with 2-week intervals with the new bipolar RF device undergoing photographic monitoring before treatment and at the end of the cycle of sessions. In addition, 15 patients from the sample group were subjected to 2 biopsies, one at the start of treatment and the other 3 months after the last treatment. All the patients showed improvement in treated imperfections from the second session onward, and they expressed their satisfaction at the end of the treatment cycle. The most notable clinical, histological, and immunohistochemical results were observed in the patients with abdominal striae distensae. In most cases, the temporary side effects observed consisted of rashes and ecchymosis. Two patients reported the formation of blisters on the treated area caused by excessively high RF settings. The new bipolar RF device proved to be effective, noninvasive, and easy to use. The improvement

Understanding the Anatomy of the Upper Face When Providing Aesthetic Injection Treatments.

Science.gov (United States)

Hotta, Tracey A

2016-01-01

Advanced rejuvenation procedures for the upper face are becoming increasingly popular for aesthetic providers but are considered a high-risk treatment area for dermal filler/contouring products. Risks may range from bruising, which is manageable, to blindness, most often irreversible. Detailed comprehension of the facial anatomy is imperative when performing aesthetic injections including neuromodulators and dermal filler/contouring products. Understanding the location and function of the muscles, as well as landmarking the blood vessels and nerves, will assist the aesthetic provider to perform safe, confident injection procedures. This article focuses on the upper face anatomy as identified by the author's cadaveric dissections and includes the treatment areas of the frontalis, temporalis, and glabellar complex. The author's next article for the Plastic Surgical Nursing journal will focus on the periorbital area.

Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.

Science.gov (United States)

Fajkus, J; Simícková, M; Maláska, J

2002-04-29

The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase (a cellular reverse transcriptase that synthesizes telomeres) for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations, respectively. This article reviews the basic data on structure and function of human telomeres and telomerase, as well as both passive and active applications of human telomere biology.

Ablative skin resurfacing.

Science.gov (United States)

Agrawal, Nidhi; Smith, Greg; Heffelfinger, Ryan

2014-02-01

Ablative laser resurfacing has evolved as a safe and effective treatment for skin rejuvenation. Although traditional lasers were associated with significant thermal damage and lengthy recovery, advances in laser technology have improved safety profiles and reduced social downtime. CO2 lasers remain the gold standard of treatment, and fractional ablative devices capable of achieving remarkable clinical improvement with fewer side effects and shorter recovery times have made it a more practical option for patients. Although ablative resurfacing has become safer, careful patient selection and choice of suitable laser parameters are essential to minimize complications and optimize outcomes. This article describes the current modalities used in ablative laser skin resurfacing and examines their efficacy, indications, and possible side effects. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.