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Sample records for rejected cmaj manuscripts

  1. The fate of triaged and rejected manuscripts

    Science.gov (United States)

    Zoccali, Carmine; Amodeo, Daniela; Argiles, Angel; Arici, Mustafa; D'arrigo, Graziella; Evenepoel, Pieter; Fliser, Danilo; Fox, Jonathan; Gesualdo, Loreto; Jadoul, Michel; Ketteler, Markus; Malyszko, Jolanta; Massy, Ziad; Mayer, Gert; Ortiz, Alberto; Sever, Mehmet; Vanholder, Raymond; Vinck, Caroline; Wanner, Christopher; Więcek, Andrzej

    2015-01-01

    In 2011, Nephrology Dialysis and Transplantation (NDT) established a more restrictive selection process for manuscripts submitted to the journal, reducing the acceptance rate from 25% (2008–2009) to currently about 12–15%. To achieve this goal, we decided to score the priority of manuscripts submitted to NDT and to reject more papers at triage than in the past. This new scoring system allows a rapid decision for the authors without external review. However, the risk of such a restrictive policy may be that the journal might fail to capture important studies that are eventually published in higher-ranked journals. To look into this problem, we analysed random samples of papers (∼10%) rejected by NDT in 2012. Of the papers rejected at triage and those rejected after regular peer review, 59 and 61%, respectively, were accepted in other journals. A detailed analysis of these papers showed that only 4 out of 104 and 7 out of 93 of the triaged and rejected papers, respectively, were published in journals with an impact factor higher than that of NDT. Furthermore, for all these papers, independent assessors confirmed the evaluation made by the original reviewers. The number of citations of these papers was similar to that typically obtained by publications in the corresponding journals. Even though the analyses seem reassuring, previous observations made by leading journals warn that the risk of ‘big misses’, resulting from selective editorial policies, remains a real possibility. We will therefore continue to maintain a high degree of alertness and will periodically track the history of manuscripts rejected by NDT, particularly papers that are rejected at triage by our journal. PMID:26597920

  2. Fate of Manuscripts Rejected From the Red Journal

    Energy Technology Data Exchange (ETDEWEB)

    Holliday, Emma B., E-mail: emmaholliday@gmail.com [Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Yang, George [The University of South Florida Morsani College of Medicine, Tampa, Florida (United States); Jagsi, Reshma [Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan (United States); Hoffman, Karen E. [Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Bennett, Katherine Egan; Grace, Calley [Scientific Publications, American Society for Radiation Oncology, Fairfax, Virginia (United States); Zietman, Anthony L. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2015-01-01

    Purpose: To evaluate characteristics associated with higher rates of acceptance for original manuscripts submitted for publication to the International Journal of Radiation Oncology • Biology • Physics (IJROBP) and describe the fate of rejected manuscripts. Methods and Materials: Manuscripts submitted to the IJROBP from May 1, 2010, to August 31, 2010, and May 1, 2012, to August 31, 2012, were evaluated for author demographics and acceptance status. A PubMed search was performed for each IJROBP-rejected manuscript to ascertain whether the manuscript was ultimately published elsewhere. The Impact Factor of the accepting journal and the number of citations of the published manuscript were also collected. Results: Of the 500 included manuscripts, 172 (34.4%) were accepted and 328 (65.6%) were rejected. There was no significant difference in acceptance rates according to gender or degree of the submitting author, but there were significant differences seen based on the submitting author's country, rank, and h-index. On multivariate analysis, earlier year submitted (P<.0001) and higher author h-index (P=.006) remained significantly associated with acceptance into the IJROBP. Two hundred thirty-five IJROBP-rejected manuscripts (71.7%) were ultimately published in a PubMed-listed journal as of July 2014. There were no significant differences in any submitting author characteristics. Journals accepting IJROBP-rejected manuscripts had a lower median [interquartile range] 2013 impact factor compared with the IJROBP (2.45 [1.53-3.71] vs 4.176). The IJROBP-rejected manuscripts ultimately published elsewhere had a lower median [interquartile range] number of citations (1 [0-4] vs 6 [2-11]; P<.001), which persisted on multivariate analysis. Conclusions: The acceptance rate for manuscripts submitted to the IJROBP is approximately one-third, and approximately 70% of rejected manuscripts are ultimately published in other PubMed-listed journals, but these ultimate

  3. From Rejected to Accepted: Part 1--Strategies for Revising and Resubmitting a Manuscript

    Science.gov (United States)

    Stivers, Jan; Cramer, Sharon

    2017-01-01

    Manuscript rejection is a fact of life for academics, and should be seen as just one step in a process of revision and resubmission that typically results in publication. This two-part article offers suggestions to help authors take action on their rejected manuscripts, including analyzing reviewer feedback, revising judiciously, and making…

  4. Manuscript rejection: how to submit a revision and tips on being a good peer reviewer.

    Science.gov (United States)

    Kotsis, Sandra V; Chung, Kevin C

    2014-04-01

    Many instructional guides have been published on how to write scientific papers. Likewise, many published articles have focused on the reasons why submitted manuscripts are rejected. However, fewer publications have been presented to guide authors on how to address reviewers' comments in a manuscript revision. Even fewer counsel authors on how to deal with a rejection decision. In this article, the authors present a literature review on the strategies to get a manuscript accepted, despite an initial unfavorable review. The authors share their experience with addressing reviewers' comments to get a manuscript accepted and published. Finally, the authors discuss the process of peer review and offer tips on how to be an effective peer reviewer.

  5. Fate of manuscripts rejected by a non-English-language general medical journal

    DEFF Research Database (Denmark)

    Vinther, Siri; Rosenberg, Jacob

    2011-01-01

    Objective The objective of this study was to determine whether, where and when manuscripts were published following rejection by the Journal of the Danish Medical Association, a general medical journal published in Danish. Similar previous studies have focused on specialty/subspecialty journals p...... translation could be a barrier for resubmitting to English-language journals with larger readerships, thus hindering the dissemination of knowledge to the international community....... evaluated. Results Of 198 rejected manuscripts, 21 (10.6%) were eventually published after a median of 685 days (range 209-1463). The majority of these were original research, published in English-language specialty/subspecialty journals. The median number of citations per article was 2-3 (IQR 0.......5-9.5, depending on the database searched). Conclusions 10.6% of the rejected manuscripts were eventually published in other journals, mainly English-language specialty journals. This proportion was considerably lower than that for other journals that have studied the fate of rejected manuscripts. Manuscript...

  6. Fate of manuscripts rejected by a non-English-language general medical journal

    DEFF Research Database (Denmark)

    Vinther, Siri; Rosenberg, Jacob

    2011-01-01

    evaluated. Results Of 198 rejected manuscripts, 21 (10.6%) were eventually published after a median of 685 days (range 209-1463). The majority of these were original research, published in English-language specialty/subspecialty journals. The median number of citations per article was 2-3 (IQR 0...... translation could be a barrier for resubmitting to English-language journals with larger readerships, thus hindering the dissemination of knowledge to the international community.......Objective The objective of this study was to determine whether, where and when manuscripts were published following rejection by the Journal of the Danish Medical Association, a general medical journal published in Danish. Similar previous studies have focused on specialty/subspecialty journals...

  7. Analysis of the Revision Process by American Journal of Roentgenology Reviewers and Section Editors: Metrics of Rejected Manuscripts and Their Final Disposition.

    Science.gov (United States)

    Cejas, Claudia

    2017-06-01

    The objective of this study was to evaluate metrics related to manuscripts rejected by AJR with and without review during 2014 and to determine their final disposition: no record of eventual publication, eventually published, published with modified authors and title, published with the same title but modified authors, and published with modified title but the same authors. A total of 1245 unsolicited manuscripts submitted from January to December 2014 were included in this retrospective analysis. Data were extracted from the AJR's manuscript submission system. Standard statistical analysis was used to assess the fate of a sample of 200 rejected manuscripts. Of the 200 manuscripts studied, 117 (59%) were published in other scientific journals (61 with revision, 56 without revision; Χ(2) = 0.329, p = 0.566). Thirty-two of the 61 manuscripts (52%) rejected after peer review were later published in other journals without changes in their titles or authors, 16 (26%) with changes only in authors, 10 (16%) with changes only in their titles, and three (5%) with changes in authors and titles. Twenty-six of the 56 manuscripts (46%) rejected without peer review were published without changes in their titles or authors, 17 (30%) with changes in authors, 11 (20%) with changes only in their titles, and two (4%) with changes in both authors and titles (p = 0.686). Ten articles were published in open access journals. Of the remaining articles, those that had been reviewed were published in journals with a mean impact factor ± SD of 2.37 ± 1.30, and those that had not been reviewed were published in journals with a mean impact factor of 2.04 ± 1.06. Analysis of the 25th and 75th percentiles revealed that values were also higher for the group rejected with review (Wilcoxon rank sum test: W = 1679, p = 0.1127). Out of 61 articles rejected for publication with review, 52.5% were published with changes to their abstracts, whereas the remaining 47.5% were unchanged. This analysis

  8. A look at CMAJ: A misty image indeed

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2006-03-01

    Full Text Available The date: Feb 20, 2006. Medical publishing was rocked by the sudden dismissal of the Editor In Chief of the CMAJ (Canadian Medical Association Journal, John Hoey, and a Senior Deputy Editor Anne Mary Todkill. The Editor appointed in the interim, Stephen Choe and another Deputy Editor Sally Murray, also resigned in a week's time, on 28 Feb to be precise. Along with them also went Jerome Kassirer, a former CMAJ editorial board member and a former editor of the New England Journal of Medicine (NEJM, appointed to frame regulations or governance plans about editorial independence. All these are well-respected professionals in the field of biomedical publication and there has been a huge outcry, both in the medical as well as popular press, at their abrupt sacking. If this were not enough, fifteen out of the nineteen members of the editorial board of the CAMJ also resigned, precipitating a grave crisis. In the meanwhile, the CMA, in an attempt at damage control, appointed an interim Editor, Noni Macdonald, along with an Editor Emeritus, Bruce Squires, who has been an earlier editor of CMAJ , and a founder member of WAME. A retired Chief Justice of the Canadian Supreme Court has been appointed to chalk out a Governance Plan for Editorial independence. Changes are also envisaged in the JOC (Journal Oversight Committee. The CMA President is exhorting everyone concerned to move on, and has assured a policy of editorial independence. The atmosphere, at the time of writing this, is combative and smoldering, and a distinct unease prevails. [No abstract available.

  9. Writing Biomedical Manuscripts Part II: Standard Elements and ...

    African Journals Online (AJOL)

    Several reasons account for rejection or delay of manuscripts submitted to ... The chances of manuscript acceptance can be increased by paying attention to the ... follow the universally accepted pattern of aim, introduction, methods, results, ...

  10. Uniform Requirements for Manuscripts

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ Introduction The Uniform requirements are instructions to authors on how to prepare manuscripts.If authors prepare their manuscripts in the style specified in these requirements, editors of the participating journals will not return the manuscripts for changes in style before considering them for publication.In the publishing process, however, the journals may alter accepted manuscripts to conform with details of their publication styles.

  11. Latin manuscript missal

    Directory of Open Access Journals (Sweden)

    Marijan Smolik

    2003-01-01

    Full Text Available The paper describes the origins and content of the latin manuscript missal marked Bergendal MS 40, which is part of the Bergendal Collection of manuscripts and incunables in Toronto. This manuscript had once been used as a missal by the priests in the Church of St. Daniel in Zalog. The author points to the fact that the analysed missal lacks the texts which are otherwise included in complete missals. On these grounds, he assumes that the buyers of the missal for the Slavina (today Postojna parsonage did not buy the missal, which had been available, but had had only parts of it copied, the parts they presumed to be used and of use in the local church.

  12. Improving the efficiency of manuscript selection

    Directory of Open Access Journals (Sweden)

    A. Martínez–Abrain

    2009-01-01

    Full Text Available Science relies strongly on the publication of articles in scientific journals and it is clear that decisions concer¬ning which papers merit publishing should be based on a process of manuscript selection that is as objective, repeatable, reliable and transparent as possible. Manuscript selection, however, has many practical downfalls. There is considerable controversy concerning issues such as whether or not the process should be blind both for authors and reviewers in order to prevent biased selection in relation to country of origin (Budden et al., 2008, sex (Young et al. 2008 or research topic (Michaels, 2008. Another critical point is the imbalance between supply and demand of manuscripts as this likely leads to biased selection (Young et al., 2008. Also important is the issue that following rejection, the editor and reviewers of the new journal selected for would-be publication by the authors start the process from scratch, as if the opus had not already passed through a thorough process of peer review. Such rules of play seem to promote the role of sheer luck in the process of manuscript selection. Authors of a rejected paper have the growing hope of "greater luck" the next time regarding reviewer assignment as they believe in the quality of their work. For the correct advancement of science I consider there should be a common global database available to editors, where each manuscript which has been subjected to an SCI journal is recorded. It should include a copy of the editor’s and reviewers’ comments, and also the authors’ replies. Hochberg et al. (2009 recently expressed their concern regarding the fact that authors usually think that manuscript submittal is a stochastic process, whereas in fact reviewers usually focus on the same set of criticisms. To solve this problem they suggest a having colleagues reviewing a manuscript before submission, and b requiring authors to state in a cover letter that reviewer comments from the

  13. Transplant rejection

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000815.htm Transplant rejection To use the sharing features on this page, please enable JavaScript. Transplant rejection is a process in which a transplant ...

  14. EDITORIAL AVOIDABLE MORTALITY OF SCIENTIFIC MANUSCRIPTS

    Directory of Open Access Journals (Sweden)

    Mauricio Palacios

    2010-06-01

    Full Text Available Colombia Médica publishes 64% of the original research articles submitted to editorial process, which highlights the rigor of the editorial review system; while at the same time, generating a reflection on the causes for rejecting material submitted for publication as an input for the Journal’s collaborators.The review of the file of articles rejected by the Journal leads us to arbitrarily discriminating the causes for rejecting scientific documents into two groups: A first group we will call «lost causes», which centers on the lack of ethical evaluation, research design flaws, and plagiarism. And the second group, «manuscripts with avoidable rejection», which includes deficiencies in following the editorial guidelines for authors, inadequate writing, and delays by authors in submitting answers to observations raised during an initial evaluation. Documents classifying in the latter group could have had an opportunity with a bit of joint effort between the authors and the editorial board; and in all cases, by correcting errors and seeking support from, among others, expert consultants, these could, potentially, be revived by submitting them to a journal with a lower impact than that in which they were rejected.Among the reasons for the lost causes, we find that faults in the structure of institutional research take up considerable space. Institutions considering scientific production as one of their assets, must invest on the conformation and growth of an ethics committee on research that reasonably provides researchers with social, environmental, and ethical reflection elements to enrich research proposals. With bioethics foundations, Colombian and international norms do not consider other forms of ethical evaluation of the projects, and; consequently, neither does the Editorial Committee. Furthermore, anyone seeking to conduct clinical trials must register the entity in any of the international data bases that permit inputting the

  15. EDITORIAL AVOIDABLE MORTALITY OF SCIENTIFIC MANUSCRIPTS

    Directory of Open Access Journals (Sweden)

    Mauricio Palacios

    2010-06-01

    Full Text Available Colombia Médica publishes 64% of the original research articles submitted to editorial process, which highlights the rigor of the editorial review system; while at the same time, generating a reflection on the causes for rejecting material submitted for publication as an input for the Journal’s collaborators. The review of the file of articles rejected by the Journal leads us to arbitrarily discriminating the causes for rejecting scientific documents into two groups: A first group we will call «lost causes», which centers on the lack of ethical evaluation, research design flaws, and plagiarism. And the second group, «manuscripts with avoidable rejection», which includes deficiencies in following the editorial guidelines for authors, inadequate writing, and delays by authors in submitting answers to observations raised during an initial evaluation. Documents classifying in the latter group could have had an opportunity with a bit of joint effort between the authors and the editorial board; and in all cases, by correcting errors and seeking support from, among others, expert consultants, these could, potentially, be revived by submitting them to a journal with a lower impact than that in which they were rejected. Among the reasons for the lost causes, we find that faults in the structure of institutional research take up considerable space. Institutions considering scientific production as one of their assets, must invest on the conformation and growth of an ethics committee on research that reasonably provides researchers with social, environmental, and ethical reflection elements to enrich research proposals. With bioethics foundations, Colombian and international norms do not consider other forms of ethical evaluation of the projects, and; consequently, neither does the Editorial Committee. Furthermore, anyone seeking to conduct clinical trials must register the entity in any of the international data bases that permit inputting the

  16. Writing biomedical manuscripts part I: fundamentals and general rules.

    Science.gov (United States)

    Ohwovoriole, A E

    2011-01-01

    It is a professional obligation for health researchers to investigate and communicate their findings to the medical community. The writing of a publishable scientific manuscript can be a daunting task for the beginner and to even some established researchers. Many manuscripts fail to get off the ground and/or are rejected. The writing task can be made easier and the quality improved by using and following simple rules and leads that apply to general scientific writing .The manuscript should follow a standard structure:(e.g. (Abstract) plus Introduction, Methods, Results, and Discussion/Conclusion, the IMRAD model. The authors must also follow well established fundamentals of good communication in science and be systematic in approach. The manuscript must move from what is currently known to what was unknown that was investigated using a hypothesis, research question or problem statement. Each section has its own style of structure and language of presentation. The beginning of writing a good manuscript is to do a good study design and to pay attention to details at every stage. Many manuscripts are rejected because of errors that can be avoided if the authors follow simple guidelines and rules. One good way to avoid potential disappointment in manuscript writing is to follow the established general rules along with those of the journal in which the paper is to be published. An important injunction is to make the writing precise, clear, parsimonious, and comprehensible to the intended audience. The purpose of this article is to arm and encourage potential biomedical authors with tools and rules that will enable them to write contemporary manuscripts, which can stand the rigorous peer review process. The expectations of standard journals, and common pitfalls the major elements of a manuscript are covered.

  17. Mediaeval manuscript bindings

    Directory of Open Access Journals (Sweden)

    Jedert Vodopivec

    1999-01-01

    Full Text Available The present article represents an excerpt from the final chapters of the research study titled "The development of structures in mediaeval manuscript bindings - interdependence with conservatory methods". In it, aims, methods of work, archive and library materials used and directions for conservatory methods are presented. Besides, the research study includes also a historcial overview of book bindings, detailed analysis of separate structural elements in Slovenian mediaeval bindings, comprehensive presentation of separate structures, the techniques of binding and materials of the preserved mediaeval bindings in Slovenian public archives and libraries, terminological dictionary of specific professional terms related to binding as a segment of a book, and a catalogue of all analysed bindings, containing a survey of ajI detectable data, sketches,graphite prints and photographs.

  18. How authors can maximise the chance of manuscript acceptance and article visibility

    NARCIS (Netherlands)

    Kalwij, Jesse M.; Smit, Christian

    2013-01-01

    The current peer-review system is being overloaded with manuscript submissions that increasingly exceed reviewer availability and journal publication space. Consequently manuscript rejections rates, peer-review requests, and subject-editors' workloads are mounting. Here we outline common problems wi

  19. Rejecting Change

    Institute of Scientific and Technical Information of China (English)

    KERRY; BROWN

    2011-01-01

    British voters overwhelmingly reject an alternative voting system The British electorate,in only the second ever national referendum held in their history (the first was on joining the EU,over 35 years ago) rejected alterations to their voting system from the current first-past-the-post system to a form of alternative voting similar to that used

  20. The Margins of Medieval Manuscripts

    Directory of Open Access Journals (Sweden)

    Nataša Kavčič

    2011-12-01

    Full Text Available Shortly after the mid-thirteenth century, various images began to fill the margins in both religious and secular texts. Many factors influenced the emergence of this type of manuscript decoration, but it has generally been attributed to the revived interest in nature and the Gothic inclination for humorous and anecdotic detail. After highlighting other possible reasons for the occurrence of marginal illumination, this paper introduces two manuscripts from the Archiepiscopal Archives in Ljubljana. The manuscripts show numerous facial drawings affixed to some of the letters. This article addresses how to interpret such drawings and stresses that they do not necessarily function as symbolic images or images with any specific didactic value. Quite the opposite, these drawings seem not to have any meaning and are oft en merely indications of an illuminator’s sense of humor. Because of their exaggerated facial expressions, these drawings could be perceived as the true predecessors of modern caricature.

  1. Reviewing manuscripts for biomedical journals.

    Science.gov (United States)

    Garmel, Gus M

    2010-01-01

    Writing for publication is a complex task. For many professionals, producing a well-executed manuscript conveying one's research, ideas, or educational wisdom is challenging. Authors have varying emotions related to the process of writing for scientific publication. Although not studied, a relationship between an author's enjoyment of the writing process and the product's outcome is highly likely. As with any skill, practice generally results in improvements. Literature focused on preparing manuscripts for publication and the art of reviewing submissions exists. Most journals guard their reviewers' anonymity with respect to the manuscript review process. This is meant to protect them from direct or indirect author demands, which may occur during the review process or in the future. It is generally accepted that author identities are masked in the peer-review process. However, the concept of anonymity for reviewers has been debated recently; many editors consider it problematic that reviewers are not held accountable to the public for their decisions. The review process is often arduous and underappreciated, one reason why biomedical journals acknowledge editors and frequently recognize reviewers who donate their time and expertise in the name of science. This article describes essential elements of a submitted manuscript, with the hopes of improving scientific writing. It also discusses the review process within the biomedical literature, the importance of reviewers to the scientific process, responsibilities of reviewers, and qualities of a good review and reviewer. In addition, it includes useful insights to individuals who read and interpret the medical literature.

  2. Twelve tips for getting your manuscript published.

    Science.gov (United States)

    Cook, David A

    2016-01-01

    The author shares twelve practical tips on how to navigate the process of getting a manuscript published. These tips, which apply to all fields of academic writing, advise that during the initial preparation phase authors should: (1) plan early to get it out the door; (2) address authorship and writing group expectations up front; (3) maintain control of the writing; (4) ensure complete reporting; (5) use electronic reference management software; (6) polish carefully before they submit; (7) select the right journal; and (8) follow journal instructions precisely. Rejection after the first submission is likely, and when this occurs authors should (9) get it back out the door quickly, but first (10) take seriously all reviewer and editor suggestions. Finally, when the invitation comes to revise and resubmit, authors should (11) respond carefully to every reviewer suggestion, even if they disagree, and (12) get input from others as they revise. The author also shares detailed suggestions on the creation of effective tables and figures, and on how to respond to reviewer critiques.

  3. Catalogue of Korean manuscripts and rare books

    DEFF Research Database (Denmark)

    Lerbæk Pedersen, Bent

    2014-01-01

    Catalogue of Korean manuscripts and rare books in The Royal Library, Copenhagen and the National Museum of Denmark......Catalogue of Korean manuscripts and rare books in The Royal Library, Copenhagen and the National Museum of Denmark...

  4. Preparing manuscript: Scientific writing for publication

    Science.gov (United States)

    Bajwa, Sukhminder Jit Singh; Sawhney, Chhavi

    2016-01-01

    Publication has become a burning issue among Indian medical fraternity owing to certain academic and professional necessities. The large number of submissions to the anaesthesia journals has resulted in accumulation of too much below average scientific material. A properly written manuscript is the dream of every editor and reviewer. The art of preparing a manuscript can be acquired only by following certain basic rules and technical aspects, besides knowledge and skills. Before preparing the manuscript, a target journal should be considered. All the instructions to the authors pertaining to that particular journal should be followed meticulously before preparing the manuscript for submission. The basic structure of the manuscript to be followed can be summarised by the acronym IMRaD (introduction, methods, results and discussion). The current review article aims to highlight all those mandatory and desirable features which should be kept in consideration while preparing a scientific manuscript for publication. PMID:27729696

  5. Husserl’s manuscript A I 35

    NARCIS (Netherlands)

    Ierna, Carlo; Lohmar, Dieter; Husserl, Edmund; Rosado Haddock, Guillermo

    2016-01-01

    The following pages contain a partial edition of Husserl’s manuscript A I 35, pages 1a-28b. The first few pages are dated on May 1927 and are included mostly for completeness’ sake. The bulk of the manuscript convolute, however, is from 1912. Four pages of the convolute, 31a-34b, have been published

  6. Typing Manuscripts and Reports. Typing 13.

    Science.gov (United States)

    Nederland Independent School District, TX.

    GRADES OR AGES: Grade 13. SUBJECT MATTER: Typing manuscripts and reports. ORGANIZATION AND PHYSICAL APPEARANCE: The introductory material contains general instructions on spacing, margins, and paging. The main text contains 32 manuscripts which are varied according to arrangement and length. The guide is lithographed and spiral bound with a soft…

  7. Husserl’s manuscript A I 35

    NARCIS (Netherlands)

    Ierna, Carlo; Lohmar, Dieter; Husserl, Edmund; Rosado Haddock, Guillermo

    2016-01-01

    The following pages contain a partial edition of Husserl’s manuscript A I 35, pages 1a-28b. The first few pages are dated on May 1927 and are included mostly for completeness’ sake. The bulk of the manuscript convolute, however, is from 1912. Four pages of the convolute, 31a-34b, have been published

  8. The Challenge of Editing Einstein's Scientific Manuscripts

    CERN Document Server

    Sauer, T

    2004-01-01

    Einstein's research manuscripts provide important insights into his exceptional creativity. At the same time, they can present difficulties for a publication in the documentary edition of the Collected Papers of Albert Einstein (CPAE). The problems are illustrated by discussing how some important examples of Einstein's research manuscripts have been included in previous volumes of the CPAE series: his Scratch Notebook from the years 1910-1914, his so-called Zurich Notebook from 1912, documenting his early search for a generally covariant theory of gravitation, and the Einstein-Besso manuscript from 1913, containing calculations of Mercury's perihelion advance on the basis of the Einstein-Grossmann equations. Another category of research notes are "back-of-an-envelope" calculations. A major challenge for future volumes of the CPAE series are Einstein's Berlin and Princeton research manuscripts on a unified field theory. This batch of some 1700 undated manuscript pages presents a formidable challenge also for h...

  9. PLATFORM OF TRANSCRIPTION THE OLD ARABIC MANUSCRIPTS

    Directory of Open Access Journals (Sweden)

    Noureddine EL MAKHFI

    2011-06-01

    Full Text Available The old manuscripts kept in libraries are a part of the richest cultural heritage and legacy of civilizations. Digitalization is a solution for the preservation of this cultural and historical heritage, which is very difficult to handle for users. On the other hand, restriction of access to national heritage manuscript is related to the concern to preserve the manuscripts physically manipulated which contribute to their accelerated degradation, takinginto consideration these limitations on access while ensuring preservation of original manuscripts, the solution widely adopted is based partly on the digitization of this heritage manuscript, and partly on the development of management platforms and diffusion of this wealth of knowledge digitized. We propose in this paper a platform of transcription and establishment by annotating images of manuscripts, these annotations are respecting a XML model. The search in the images of a handwritten document, the rich functionality, intuitive user interface, portability, extensibility and the powerful of the XML technology all make the platform of transcription and establishment an ideal explorer for a specialists and readers of ancient Arabic manuscripts.

  10. Preparing and Publishing a Scientific Manuscript

    Directory of Open Access Journals (Sweden)

    Padma R Jirge

    2017-01-01

    Full Text Available Publishing original research in a peer-reviewed and indexed journal is an important milestone for a scientist or a clinician. It is an important parameter to assess academic achievements. However, technical and language barriers may prevent many enthusiasts from ever publishing. This review highlights the important preparatory steps for creating a good manuscript and the most widely used IMRaD (Introduction, Materials and Methods, Results, and Discussion method for writing a good manuscript. It also provides a brief overview of the submission and review process of a manuscript for publishing in a biomedical journal.

  11. DVD Database Astronomical Manuscripts in Georgia

    Science.gov (United States)

    Simonia, I.; Simonia, Ts.; Abuladze, T.; Chkhikvadze, N.; Samkurashvili, L.; Pataridze, K.

    2016-06-01

    Little known and unknown Georgian, Persian, and Arabic astronomical manuscripts of IX-XIX centuries are kept in the centers, archives, and libraries of Georgia. These manuscripts has a form of treaties, handbooks, texts, tables, fragments, and comprises various theories, cosmological models, star catalogs, calendars, methods of observations. We investigated this large material and published DVD database Astronomical Manuscripts in Georgia. This unique database contains information about astronomical manuscripts as original works. It contains also descriptions of Georgian translations of Byzantine, Arabic and other sources. The present paper is dedicated to description of obtained results and DVD database. Copies of published DVD database are kept in collections of the libraries of: Ilia State University, Georgia; Royal Observatory, Edinburgh, UK; Congress of the USA, and in other centers.

  12. source files for manuscript in tex format

    Data.gov (United States)

    U.S. Environmental Protection Agency — Source tex files used to create the manuscript including original figure files and raw data used in tables and inline text. This dataset is associated with the...

  13. Astronomical knowledge transmission through illustrated Aratea manuscripts

    CERN Document Server

    Dolan, Marion

    2017-01-01

    This carefully researched monograph is a historical investigation of the illustrated Aratea astronomical manuscript and its many interpretations over the centuries. Aratus' 270 B.C.E. Greek poem describing the constellations and astrological phenomena was translated and copied over 800 years into illuminated manuscripts that preserved and illustrated these ancient stories about the constellations. The Aratea survives in its entirety due to multiple translations from Greek to Latin and even to Arabic, with many illuminated versions being commissioned over the ages. The survey encompasses four interrelated disciplines: history of literature, history of myth, history of science, and history of art. Aratea manuscripts by their nature are a meeting place of these distinct branches, and the culling of information from historical literature and from the manuscripts themselves focuses on a wider, holistic view; a narrow approach could not provide a proper prospective. What is most essential to know about this work is...

  14. The changing role of the manuscript librarian

    Directory of Open Access Journals (Sweden)

    Ad Leerintveld

    2003-06-01

    Full Text Available In December 2000 about 40 manuscript librarians from Europe met in Stockholm answering the initiative of Anders Burius, manuscript librarian of the Royal Library of Sweden. The participating colleagues agreed in forming an Expert Group of Manuscript Librarians under the auspices of LIBER. In July 2001 LIBER's General Conference in London formally approved the Expert Group. In February 2002 the Provisional Board elected in Stockholm, constituted itself. André Bouwman (The Netherlands became chairman, Anders Burius (Sweden secretary, Eef Overgauw (Germany, Bernard Meehan (Ireland and Felix Heinzer (Germany became members of the Board, all for the period 2002-2004. At the end of the Stockholm Conference Els van Eijck, deputy general director of the Koninklijke Bibliotheek, the national library of the Netherlands, invited the European manuscript librarians to hold the second conference in The Hague. This article deals with the results of that second conference, actually held from 5 - 8 March in The Hague.

  15. The Challenge of Editing Einstein's Scientific Manuscripts

    OpenAIRE

    Sauer, Tilman

    2004-01-01

    Einstein's research manuscripts provide important insights into his exceptional creativity. At the same time, they can present difficulties for a publication in the documentary edition of the Collected Papers of Albert Einstein (CPAE). The problems are illustrated by discussing how some important examples of Einstein's research manuscripts have been included in previous volumes of the CPAE series: his Scratch Notebook from the years 1910-1914, his so-called Zurich Notebook from 1912, document...

  16. [Medical manuscript of Mihail Plamenac, a priest].

    Science.gov (United States)

    Milović, I

    1998-01-01

    It is known that collections of popular medical prescriptions and instructions appeared in areas without educated physicians, and all previously published manuscripts of this kind are inevitably anonymous. The reported manuscript comprises 23 pages written in sepia ink, appendixed to a prayer book published in 1747, containing popular medical instructions and prescriptions collected and practiced by orthodox priest Mihailo Plamenac in Montenegro at the turn of the 18th century. Mihailo Plamenac took an important part in historical events, as documented by numerous domestic historical data and several letters discovered in The Archives of Vienna. Being the only literate persons at the time, priests were both politicians and military officers, but they also offered medical services to the population. The manuscript comprises advices for various common emergencies (snake bites, urinary retention, contusions, fever, burns, eye injuries, rabies, otitis, traumatic wryneck) and diseases(impetigo, scabies, infertility, gastric ulcer, low back pain) as well as for certain poorly defined conditions (chest pain, abdominal discomfort). Besides medically fully adequate treatment, for example, the remedy against scabies containing sulfur, there are numerous examples of magic and ritual pagan elements, including famous medieval SATOR formula against rabies. Most of the herbs used in prescriptions have been identified: fig, dog rose, hyssop, leek, laurel, absinthe, rosemary, mallow, cypress, elder, endive, mangel, orache, ivy. The manuscript is the first manuscript undoubtedly attributed to a well known historical personality, as indicated in the first page of the manuscript: "This is a medical prayer book by Mihailo Plamenac, left to him by his ancestors."

  17. Writing in aphasia rehabilitation: cursive vs manuscript.

    Science.gov (United States)

    Boone, D R; Friedman, H M

    1976-11-01

    Reading and writing performance was observed in 30 adult aphasic patients to determine whether there was a significant difference when stimuli and manual responses were varied in the written form: cursive versus manuscript. Patients were asked to read aloud 10 words written cursively and 10 words written in manuscript form. They were then asked to write on dictation 10 words responses using cursive writing and 10 words using manuscript writing. Number of words correctly read, number of words correctly written, and number of letters correctly written in the proper sequence were tallied for both cursive and manuscript writing tasks for each patient. Results indicated no significant difference in correct response between cursive and manuscript writing style for these aphasic patients as a group; however, it was noted that individual patients varied widely in their success using one writing form over the other. It appeared that since neither writing form showed better facilitation of performance, the writing style used should be determined according to the individual patient's own preference and best performance.

  18. [Quality of manuscript evaluation in Gaceta Sanitaria].

    Science.gov (United States)

    García, A M; Plasència, A; Fernández, E

    2002-01-01

    To describe strengths and weaknesses of peer reviews of manuscripts received in Gaceta Sanitaria in order to guide reviewers selection, to improve quality of peer reviews and to establish an internal system to be incorporated to the editorial process of handling manuscripts. 100 peer reviews of 55 manuscripts received during 2000 and 2001 were included. A questionnaire containing closed questions assessing specific and general components of reviews' quality was applied (answers Yes/No or on a 5-points scale). Descriptive and correlation analyses were performed for the different items in the questionnaire. An Index of Quality was obtained by adding the ratings on the items in the questionnaire measuring specific quality components. Peer reviews were rated high regarding completeness of the forms for reviewers (84%), constructiveness of the comments (reviews over 3: 63%), identification of the strengths and weaknesses of the method (reviews over 3: 59%) and substantiation of the reviewer comments (reviews over 3: 58%). Assessment of the manuscript's relevance (reviews over 3: 40%) or originality (reviews over 3: 35%) were less frequent. Quality of peer reviews in Gaceta Sanitaria is good. Some weaknesses in the reviews have been pointed out. It is possible to establish a systematic process for assessing peer reviewers using simple indicators such as general utility of the review for the editorial decision and general quality of the review.

  19. Writing Quality Peer Reviews of Research Manuscripts

    Science.gov (United States)

    Ward, Phillip; Graber, Kim C.; van der Mars, Hans

    2015-01-01

    Peer review is an important mechanism for advancing knowledge in a manner deemed as acceptable by the research community. It can also serve the function of providing guidance to an author(s) to improve the likelihood that manuscripts will be accepted in peer reviewed journals. There is, however, little assistance for new or existing reviewers of…

  20. History of Manuscriptology: study of medical manuscripts.

    Science.gov (United States)

    Narayana, Ala

    2005-01-01

    Connoisseurs of different areas of learning are apt to hold their particular area higher above all else, as the 'Science of Sciences'. These sciences transmitted to a scholar or to a common man are known through the texts, which are either handwritten or printed. The marvel of accuracy with which the vast literature specially Vedic literature has been handed down or transmitted to us orally, from generation to generations in India carried from person to person through mouth and ear, is a matter of great admiration all early literature that is now available in printed form, originally hand written i. e. in the form of manuscripts is the basis for the learning of science and technology today. Hence, it is forced to grant a top place of honor to the science of Manuscriptology and can be considered as 'Science of Sciences'. The scripts; Writing tools; Languages; Conservation, Preservation, Maintenance of the manuscripts; the study of medical manuscripts and its constraints; the strategies to validate the old concepts, drugs, diseases, and methods of treatment hidden in the manuscripts and knowledge application in the medical science are discussed here under.

  1. International Symposium on Archipelago Manuscripts VIII: In Search of Local Islam in Manuscripts

    Directory of Open Access Journals (Sweden)

    Yumi SUGAHARA

    2004-08-01

    Full Text Available The production of Islamic manuscripts in the Archipelago increased from the 16th century through to the 18th century, particularly when Aceh became the centre of Islamic intellectual activities. A number of well-known 'ulama' came from this region, including Hamzah Fansuri, Shamsuddin al-Sumatrani, Nuruddin al-Raniri and Abdurrauf Singkel, who were extraordinarily productive in writing manuscripts, both for teaching and learning, and for other purposes. This manuscript writing tradition in Aceh then spread to a number of other areas in the Archipelago, such as Sulawesi, Java, and others. As a result, many Iocal manuscripts cat be found in these areas, which store knowledge specifically related to that area.Copyright (c 2014 by SDI. All right reserved.DOI: 10.15408/sdi.v11i2.621

  2. Acknowledgement of manuscript reviewers, the underappreciated contributors

    Directory of Open Access Journals (Sweden)

    Abel Lucy

    2013-02-01

    Full Text Available Contributing reviewers We and the Editorial Board acknowledge and thank all reviewers for their active participation and contribution during 2012. We greatly appreciate their dedication and behind the scenes contribution. It is largely due to their support and expertise that we have been able to publish high-standard manuscripts. We would also like to thank authors for choosing Nutrition & Metabolism and contributing their cherished work.

  3. Buton, Islamization, and this Manuscript Tradition

    Directory of Open Access Journals (Sweden)

    Ali Rosdin

    2015-04-01

    Full Text Available Buton the beginning of the country is filled with myths, which serves to form a world view of cosmocentric in determining descriptions of time, space, and society. Buton as a kingdom lasted for over two centuries (1327-1541 and then continued with a sultanate era for more than four centuries (1541-1960. During the era of the kingdom, Buton was not acquainted with script and literary tradition. Apparently, tradition of writing manuscript was firstly known in the sultanate era, when the process of Islamization began by the scholars who introduced the tradition of reading and writing the Arabic script, which was later modified into a Buton script (Buri Wolio. Sultanate built on the basis of ideology of Islam and Sufism applied teachings of “martabat tujuh” on the system and structure of government. The manuscripts tradition achieved its golden peak in the reign of the 29th Sultan, La Ode Muhammad Idrus Kaimuddin (1824-1851, which was instituted in a Zawiah school. Today, there are about 340 texts in Buton manuscripts, which are mostly found in the collections of Abdul Mulku Zahari. In addition, there are still many other texts may be found on varied other private collections, which the numbers are difficult to determine because of various reasons.

  4. Strategies to successfully publish your first manuscript.

    Science.gov (United States)

    Veness, M

    2010-08-01

    Applying published evidence is fundamental to the practice of medicine. However, the steps needed to undertake scientific research and generate a manuscript of publishable quality are often overwhelming for junior doctors. Undertaking research and publishing these findings are complementary. Clinicians often present research at college or scientific meetings as oral or poster presentations. Yet despite this, most research is not subsequently submitted for peer review publication in a scientific journal. Reasons put forward for research not being published include lack of time, ongoing study, difficulties with co-authors and a negative study. A lack of experience in the actual process of writing and publishing is also likely to be a contributing factor. The steps required in writing a successful manuscript are multiple and clinicians often lack awareness of the specific formatting requirements for submission to a scientific journal such as JMIRO. The aim of this article is to provide information for clinicians inexperienced in writing and submitting a manuscript with the intent of achieving a publication. It is not meant to be a step-by-step recipe in doing this but a guide as to what is required.

  5. Analytical investigations on the Coronation Gospels manuscript

    Science.gov (United States)

    Aceto, Maurizio; Agostino, Angelo; Fenoglio, Gaia; Idone, Ambra; Crivello, Fabrizio; Griesser, Martina; Kirchweger, Franz; Uhlir, Katharina; Puyo, Patricia Roger

    2017-01-01

    The Coronation Gospels or Krönungsevangeliar is a manuscript kept in Vienna at the Kunsthistorisches Museum Wien, datable to the end of VIII century A.D. and produced at Charlemagne court. It is an example of a purple codex, i.e. its parchment is coloured in purple. It has to be considered as one of the most important medieval codices, according to its use to take oath in the coronation ceremony of kings and emperors of the Holy Roman Empire up to 1792. In order to gather information of the manufacture of the manuscript and its present conservation state, a diagnostic investigation campaign has been carried out in situ with totally non-invasive techniques. X-ray Fluorescence Spectrometry (XRF), UV-visible diffuse reflectance spectrophotometry with optical fibres (FORS), spectrofluorimetry, optical microscopy and multispectral analysis have been applied in order to identify the colourants used in the decoration of the manuscript, with the main concern to the dye used to impart the purple hue to the parchment. The information collected was useful in order to address some of the questions raised by art historians concerning its history.

  6. Peer-review and editorial process of the Ethiopian Medical Journal: ten years assessment of the status of submitted manuscripts.

    Science.gov (United States)

    Enquselassie, Fikre

    2013-04-01

    The Ethiopian Medical Journal (EMJ) is a peer-reviewed journal, now 50 years old. Many medical journals, including EMJ, follow a peer review system that has evolved from the 18th century process for reviewing submitted manuscripts. However, not much is known about peer review and editorial processes by many authors who submit manuscripts to the EMJ. To describe procedures related to EMJ peer-review and editorial decision making and asses the status of manuscripts submitted to the journal in the ten year period between 2001 and 2010. All the minutes of the editorial board meetings of the ten years period 2001-2010 and relevant documents were reviewed. The minutes have details including date of submission, dates to and from reviewers, date of decision, number of assigned peer reviewers and comments given by reviewers for each submitted manuscript. The length of time took in the processes and the decision made (accepted or rejected) for each submitted manuscript was calculated from the dates. All submitted manuscripts passed through three stages: internal per-review by an editorial board member, external peer review by selected reviewers and final editing stage by an assigned editorial member. A total of 615 manuscripts were submitted to EMJ in the ten years period 2001-2010. Five hundred and one (82.7%) manuscripts were accepted for publication by peer reviewers, while 74 (12.2%) were rejected and 31 (5.1%) were withdrawn. Acceptance was lowest among original articles (81.3%) followed by teaching or review articles (84.3%) and case reports (89.3%). Thirty-two (8.4%) manuscripts were accepted within 6 months following submission and 50% were accepted within in one year of submission. About 6% of manuscripts were delayed for more than two years with a maximum delay of 43 months. Even though, there is a decline trend on the delay of processing manuscripts, EMJ has long to go in order to improve the quality of the journal and shorten the slow peer review process

  7. Tolerance and chronic rejection.

    OpenAIRE

    Womer, K. L.; Lee, R S; Madsen, J. C.; Sayegh, M H

    2001-01-01

    The most common cause of chronic allograft loss is an incompletely understood clinicopathological entity called chronic rejection (CR). Recent reports suggest an improvement in long-term renal allograft survival, although it is not clear from these data whether a true reduction of biopsy-proven CR has occurred. Although newer immunosuppressive medications have greatly reduced the incidence of acute rejection (AR) in the early post-transplantation period, the ideal therapy for both AR and CR w...

  8. The early mathematical manuscripts of Leibniz

    CERN Document Server

    Leibniz, G W

    2005-01-01

    The manuscripts and correspondence of Leibniz possess a special interest: they are invaluable as aids to the study of their author's part in the invention and development of the infinitesimal calculus. In addition, the main ideas behind Leibniz's philosophical theories lay here, in his mathematical work.This volume consists of two sections. The first part features Leibniz's own accounts of his work, and the second section comprises critical and historical notes and essays. An informative Introduction leads to the ""postscript"" to Leibniz's 1703 letter to James Bernoulli, his ""Historia et Ori

  9. Árni Magnússon's rearrangement of paper manuscripts

    DEFF Research Database (Denmark)

    Stegmann, Beeke

    Árni Magnússon’s rearrangement of paper manuscripts draws attention to the early history of Árni Magnússon’s(1663-1730) manuscript collection. The thesis examines Árni’s extensive rearrangement of paper manuscripts, showing that he repeatedly altered the physical composition of codices in his...

  10. Historical manuscript dating based on temporal pattern codebook

    NARCIS (Netherlands)

    He, Sheng; Samara, Petros; Burgers, Jan; Schomaker, Lambert

    2016-01-01

    Manuscript dating is an essential part of historical scholarship. This paper proposes a framework for image-based historical manuscript dating based on handwritten pattern analysis in scanned historical manuscript images. We first use a singular structural feature to extract the mid-level

  11. Árni Magnússon's rearrangement of paper manuscripts

    DEFF Research Database (Denmark)

    Stegmann, Beeke

    Árni Magnússon’s rearrangement of paper manuscripts draws attention to the early history of Árni Magnússon’s (1663-1730) manuscript collection. The thesis examines Árni’s extensive rearrangement of paper manuscripts, showing that he repeatedly altered the physical composition of codices in his...

  12. Confocal Terahertz Imaging of Ancient Manuscripts

    Science.gov (United States)

    Flammini, Mariano; Bonsi, Claudia; Ciano, Chiara; Giliberti, Valeria; Pontecorvo, Emanuele; Italia, Paola; DelRe, Eugenio; Ortolani, Michele

    2016-11-01

    Terahertz imaging has the potential to identify and decipher portions of ancient manuscripts, which may be unreadable at infrared and visible wavelengths. We use a scanning confocal terahertz microscope to scan a medieval parchment with music notes and pentagrams written with different inks. The microscope is based on a continuous-wave solid-state source at 0.3 THz, emitting in the free space with a horn antenna, and a high numerical-aperture ellipsoidal reflector. We present terahertz images with diffraction-limited lateral resolution of approximately 0.5 mm, where the different inks all give similar high contrast. Symbols written on the "verso" side of the parchment, barely glimpsed in the near-infrared photograph, leave a clear imprint in the terahertz images. Artifacts due to imperfect flatness of the parchment are also briefly discussed.

  13. A guide for digitising manuscript climate data

    Science.gov (United States)

    Brönnimann, S.; Annis, J.; Dann, W.; Ewen, T.; Grant, A. N.; Griesser, T.; Krähenmann, S.; Mohr, C.; Scherer, M.; Vogler, C.

    2006-10-01

    Hand-written or printed manuscript data are an important source for paleo-climatological studies, but bringing them into a suitable format can be a time consuming adventure with uncertain success. Before digitising such data (e.g., in the context a specific research project), it is worthwhile spending a few thoughts on the characteristics of the data, the scientific requirements with respect to quality and coverage, the metadata, and technical aspects such as reproduction techniques, digitising techniques, and quality control strategies. Here we briefly discuss the most important considerations according to our own experience and describe different methods for digitising numeric or text data (optical character recognition, speech recognition, and key entry). We present a tentative guide that is intended to help others compiling the necessary information and making the right decisions.

  14. Supplemental Guidelines, JCE Lab-Experiment Manuscripts

    Science.gov (United States)

    2000-05-01

    These guidelines supplement the Guide to Submissions (published in J. Chem. Educ. 2000, 77, 29-30 and at http://jchemed.chem.wisc.edu/Journal/Authors/ Guidelines.html or available on request from the JCE editorial office). Manuscripts that describe laboratory experiments should first follow the Guide to Submissions and then apply these Supplemental Guidelines. Rationale JCE receives many submissions that describe laboratory experiments. The broad range of experiments readers can find each month is one of our most important features. These supplemental guidelines have been designed to make published laboratory experiments as useful as possible to readers. They are based on four fundamental ideas: peer review of a lab-experiment manuscript should be based to a large degree on the written and technology-based materials used by students in the laboratory, not just on a description of those materials; JCE should print the information a reader needs to decide whether to try to use the experiment; this includes information about possible safety hazards; readers who decide to use a lab should be able to adapt it to their circumstances quickly and easily; detailed information, including student materials, should be available to adopters of an experiment in a format that is modifiable and easily adapted for use by faculty, students, and support staff. To support these goals we require that a manuscript that describes a laboratory experiment must consist of a Lab Summary and Lab Documentation. (Each of these is described in detail below.) If, after peer review, a lab-experiment manuscript is published, only the Lab Summary will be printed in JCE. The Abstract, the Lab Summary, and all Lab Documentation will be published via JCE Online. Lab Documentation is placed on the Web as PDF files that can be displayed and printed by Acrobat Reader, and as Word or Word Perfect files that can be edited by those who adopt a lab. Those without Web access can request printed copies of all

  15. Multiprocessor scheduling with rejection

    Energy Technology Data Exchange (ETDEWEB)

    Bartal, Y. [Tel-Aviv Univ. (Israel); Leonardi, S.; Marchetti-Spaccamela, A. [Universita di Roma (Italy); Sgall, J. [Mathematical Inst., Zitna (Czechoslovakia)] [and others

    1996-12-31

    We consider a version of multiprocessor scheduling with the special feature that jobs may be rejected for a certain penalty. An instance of the problem is given by m identical parallel machines and a set of n jobs, each job characterized by a processing time and a penalty. In the on-line version the jobs arrive one by one and we have to schedule or reject a job before we have any information about future jobs. The objective is to minimize the makespan of the schedule for accepted jobs plus the sum of the penalties of rejected jobs. The main result is a 1 + {phi} {approx} 2.618 competitive algorithm for the on-line version of the problem, where 0 is the golden ratio. A matching lower bound shows that this is the best possible algorithm working for all m. For fixed m we give improved bounds, in particular for m = 2 we give an optimal {phi} {approx} 1.618 competitive algorithm. For the off-line problem we present a fully polynomial approximation scheme for fixed m and an approximation algorithm which runs in time O(n log n) for arbitrary m and guarantees 2 - 1/m approximation ratio.

  16. How science survived: medieval manuscripts' "demography" and classic texts' extinction.

    Science.gov (United States)

    Cisne, John L

    2005-02-25

    Determining what fraction of texts and manuscripts have survived from Antiquity and the Middle Ages has been highly problematic. Analyzing the transmission of texts as the "paleodemography" of their manuscripts yields definite and surprisingly high estimates. Parchment copies of the foremost medieval textbooks on arithmetical and calendrical calculation closely fit age distributions expected for populations with logistic growth and manuscripts with exponential survivorship. The estimated half-lives of copies agree with Bischoff's paleographically based suggestion that roughly one in seven manuscripts survive in some form from ninth-century Carolingian workshops. On this basis, many if not most of the leading technical titles circulating in Latin probably survived, even from late Antiquity.

  17. EDITORIAL: Co-operation by Mutual Transfer of Manuscripts

    Science.gov (United States)

    Müller-Krumbhaar, H.

    2002-12-01

    Co-operation among scientifically qualified journals is essential for providing authors with a proper wide audience in the interest of the progress of sciences. The reviewing process of a scientifically qualified paper occasionally comes to the conclusion that the manuscript might be more suitable for a different journal than the one to which it was originally submitted. The author might be inclined to agree to such a transfer of his/her manuscript to a different journal, if the original submission date of the manuscript would be maintained ant the related materials transmitted as well. In order to facilitate this transfer of papers between The European Physical Journal and Europhysics Letters, the Editors-in-Chief of these journals have come to an agreement for the transfer of suitable manuscripts from one journal to another journal that should avoid unnecessary publication delays. Other journals published in Europe may join this co-operation. In case of such an intended transfer of a submitted manuscript, the editor of the journal who has received the manuscript asks the author for his agreement and contacts the editor of the other journal. He sends him the manuscript and related material from the reviewing process. The final decision on the manuscript publication stays the with then editor of the journal to which the manuscript is transferred, who can either make his decision on the basis of the existing reports or ask for complementary reports.

  18. Modeling rejection immunity

    Directory of Open Access Journals (Sweden)

    Gaetano Andrea De

    2012-05-01

    Full Text Available Abstract Background Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft, immunosuppression therapies are used, which have considerable side-effects and expose patients to opportunistic infections. The development of a model to complement the physician’s experience in specifying therapeutic regimens is therefore desirable. The present work proposes an Ordinary Differential Equations model accounting for immune cell proliferation in response to the sudden entry of graft antigens, through different activation mechanisms. The model considers the effect of a single immunosuppressive medication (e.g. cyclosporine, subject to first-order linear kinetics and acting by modifying, in a saturable concentration-dependent fashion, the proliferation coefficient. The latter has been determined experimentally. All other model parameter values have been set so as to reproduce reported state variable time-courses, and to maintain consistency with one another and with the experimentally derived proliferation coefficient. Results The proposed model substantially simplifies the chain of events potentially leading to organ rejection. It is however able to simulate quantitatively the time course of graft-related antigen and competent immunoreactive cell populations, showing the long-term alternative outcomes of rejection, tolerance or tolerance at a reduced functional tissue mass. In particular, the model shows that it may be difficult to attain tolerance at full tissue mass with acceptably low doses of a single immunosuppressant, in accord with clinical experience. Conclusions The introduced model is mathematically consistent with known physiology and can reproduce variations in immune status and allograft survival after transplantation. The model can be adapted to represent different therapeutic schemes and may offer useful indications for the optimization of

  19. Modeling rejection immunity.

    Science.gov (United States)

    De Gaetano, Andrea; Matone, Alice; Agnes, Annamaria; Palumbo, Pasquale; Ria, Francesco; Magalini, Sabina

    2012-05-20

    Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft), immunosuppression therapies are used, which have considerable side-effects and expose patients to opportunistic infections. The development of a model to complement the physician's experience in specifying therapeutic regimens is therefore desirable. The present work proposes an Ordinary Differential Equations model accounting for immune cell proliferation in response to the sudden entry of graft antigens, through different activation mechanisms. The model considers the effect of a single immunosuppressive medication (e.g. cyclosporine), subject to first-order linear kinetics and acting by modifying, in a saturable concentration-dependent fashion, the proliferation coefficient. The latter has been determined experimentally. All other model parameter values have been set so as to reproduce reported state variable time-courses, and to maintain consistency with one another and with the experimentally derived proliferation coefficient. The proposed model substantially simplifies the chain of events potentially leading to organ rejection. It is however able to simulate quantitatively the time course of graft-related antigen and competent immunoreactive cell populations, showing the long-term alternative outcomes of rejection, tolerance or tolerance at a reduced functional tissue mass. In particular, the model shows that it may be difficult to attain tolerance at full tissue mass with acceptably low doses of a single immunosuppressant, in accord with clinical experience. The introduced model is mathematically consistent with known physiology and can reproduce variations in immune status and allograft survival after transplantation. The model can be adapted to represent different therapeutic schemes and may offer useful indications for the optimization of therapy protocols in the transplanted patient.

  20. Heat rejection system

    Science.gov (United States)

    Smith, Gregory C.; Tokarz, Richard D.; Parry, Jr., Harvey L.; Braun, Daniel J.

    1980-01-01

    A cooling system for rejecting waste heat consists of a cooling tower incorporating a plurality of coolant tubes provided with cooling fins and each having a plurality of cooling channels therein, means for directing a heat exchange fluid from the power plant through less than the total number of cooling channels to cool the heat exchange fluid under normal ambient temperature conditions, means for directing water through the remaining cooling channels whenever the ambient temperature rises above the temperature at which dry cooling of the heat exchange fluid is sufficient and means for cooling the water.

  1. Religious Harmony Within Religious Manuscript (The Study of Serat Purwocampur

    Directory of Open Access Journals (Sweden)

    Bisri Ruchani

    2013-12-01

    Full Text Available Javanese manuscript is a noble  heritage that should be preserved. This study was conducted to determine the values of harmony contained in the Serat Purwocampur. The method used in this study on a content analysis and philology. Serat Purwocampur consists of four kinds of macapat song: Asmaradhana, Girisa, Pangkur, and Dhandhanggula. Briefly, this manuscript contains ancient stories and supernatural, such as gods associated with the prophets or otherwise. Value of harmony contained in this manuscript is the acculturation between Hinduism and Islam (Islamic Javanization. Islam spread peacefully in Java, in additions Islam also taught its followers (the Javanese to perform religion both syari’at and hakikat.

  2. Handling Rejection as Failure: Aspiring Writers Getting the Rejection Slip

    Directory of Open Access Journals (Sweden)

    Henrik Fürst

    2016-12-01

    Full Text Available Included in the definition of being an aspiring person is the risk of failure. Aspiring fiction writers are no exception. This article shows that the role of aspiring fiction writer involves managing three issues: the hope of being published, rejection by a publisher, and the perception of the rejection as a failure. Drawing on 47 interviews with fiction writers who have attempted to become first-time writers, the analysis shows that aspiring writers' responses to rejection are related to accepting and dismissing responsibility for having failed and admitting or dismissing the rejection as a perceived failure. Based on these findings, the article presents procedures associated with four main approaches to dealing with failure: conceding, excusing, justifying, and refusing. This conceptual framework for understanding failure contributes to a theoretical understanding of evaluation and valuation processes and their consequences and to empirical studies of rejection as career failure; it also systematizes and extends Goffmans work on cooling out strategies.

  3. An early manuscript in the history of American comparative psychology: Lewis Henry Morgan's "Animal Psychology" (1857).

    Science.gov (United States)

    Johnston, Timothy D

    2002-11-01

    Lewis Henry Morgan (1818-1881) is best known as the 1st ethnographer of Native American culture, but he also wrote on animal psychology, beginning in 1843, some 50 years before the founding of comparative psychology as a scientific discipline. Although not an evolutionist, Morgan argued that animals possess many human mental abilities, such as reason and moral judgment, and he rejected the scientific utility of the concept of instinct, a view that did not gain much currency in psychology until the rise of behaviorism in the 1920s. This 1857 manuscript, which is in the Lewis Henry Morgan Papers at the University of Rochester in Rochester, New York, formed the basis for the last chapter of his 1868 monograph on the American beaver but gives additional information on his sources and an expanded criticism of the concept of instinct.

  4. Microfilming of the Bach Manuscripts in the Staatsbibliothek Berlin.

    Science.gov (United States)

    Penzold, Leonhard

    1998-01-01

    Describes a microfilming project to preserve music manuscripts of Johann Sebastian Bach at the Staatsbibliothek Berlin (Germany), highlighting project goals, problems and peculiarities encountered filming the collection, color micrography, and black-and-white filming. (PEN)

  5. Are we training pit bulls to review our manuscripts?

    OpenAIRE

    Walbot Virginia

    2009-01-01

    Abstract Good early training of graduate students and postdocs is needed to prevent them turning into future generations of manuscript-savaging reviewers. How can we intercalate typical papers into our training?

  6. Are we training pit bulls to review our manuscripts?

    Directory of Open Access Journals (Sweden)

    Walbot Virginia

    2009-03-01

    Full Text Available Abstract Good early training of graduate students and postdocs is needed to prevent them turning into future generations of manuscript-savaging reviewers. How can we intercalate typical papers into our training?

  7. Are we training pit bulls to review our manuscripts?

    Science.gov (United States)

    Walbot, Virginia

    2009-01-01

    Good early training of graduate students and postdocs is needed to prevent them turning into future generations of manuscript-savaging reviewers. How can we intercalate typical papers into our training?

  8. [Study on two manuscripts with colored illustrations collected in France].

    Science.gov (United States)

    Liu, Yu-Ping; Cao, Hui

    2013-09-01

    Two manuscripts with colored illustrations in French libraries were investigated. The research showed that: the first manuscript with colored pictures include 2 volumes, titled Animaux et Plantes de Chine collected in Library of Museum National d'Historie Naturelle (MNHN);the other manuscript with colored pictures has only 1 volume, titled Botanique Chinoise collected in Library of Societe Asiatique, College de France, which were identified as illustrations of Ben cao gang mu (Compendium of Materia Medica) (1640 edition) by Li Shi-zhen. These pictures were copied by P. d'Incarville, and are similar to Plantes fleurs et arbres de Chine in Bibliotheque de l'Institut de Franceand, Collection de Plantes Veneneuses de la Chine Gravees et Imprimees en Couleurs par les Missionnaries Jesuites in Bibliotheque Nationale de France, respectively. The latter two manuscripts were identified as illustrations of Ben cao pin hui jing yao (Essential Collections of Materia Medica) (1700 edition).

  9. [Uses of Algae and Mosses in medicinal manuscripts].

    Science.gov (United States)

    Yavuz, Mustafa; Cobanoğlu, Gülşah

    In this study medicinal uses of Algae and Mosses are investigated in manuscripts of Ibn-i Baytar (Ibn al Baithar), Ibn-i Sina (Avicenna), Huneyn bin Ishak (Joannitus), Dioscorides and Plinius. Ulva lactuca and Fucus sp. have been identified according to the descriptions given in these manuscripts. It is designated that the Arabic term "Tuhlub" occupies both the meanings of any algal species and Lemna minor of Spermatophyta.

  10. Controllability measures for disturbance rejection

    Directory of Open Access Journals (Sweden)

    Sigurd Skogestad

    1996-07-01

    Full Text Available Some plants have better "built-in" disturbance rejection capabilities than others, that is, their dynamic resilience (controllability with respect to disturbance rejection is better. In the paper we consider controller independent disturbance measures for six classes of problems:

  11. Radionuclide diagnosis of allograft rejection

    Energy Technology Data Exchange (ETDEWEB)

    George, E.A.

    1982-10-01

    Interaction with one or more anatomical and physiopathological characteristics of the rejecting renal allograft is suggested by those radioagents utilized specifically for the diagnosis of allograft rejection. Rejection, the most common cause of declining allograft function, is frequently mimicked clinically or masked by other immediate or long term post transplant complications. Understanding of the anatomical pathological features and kinetics of rejection and their modification by immunosuppressive maintenance and therapy are important for the proper clinical utilization of these radioagents. Furthermore, in selecting these radionuclides, one has to consider the comparative availability, preparatory and procedural simplicity, acquisition and display techniques and the possibility of timely report. The clinical utilities of radiofibrinogen, /sup 99m/Tc sulfur colloid and /sup 67/Ga in the diagnosis of allograft rejection have been evaluated to a variable extent in the past. The potential usefulness of the recently developed preparations of /sup 111/In labeled autologous leukocytes and platelets are presently under investigation.

  12. Variable Heat Rejection (VHR) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop advanced technologies to enable a variable heat rejection Thermal Control System (TCS) capable of operating through a wide range of thermal environments...

  13. Image Segmentation of Historical Handwriting from Palm Leaf Manuscripts

    Science.gov (United States)

    Surinta, Olarik; Chamchong, Rapeeporn

    Palm leaf manuscripts were one of the earliest forms of written media and were used in Southeast Asia to store early written knowledge about subjects such as medicine, Buddhist doctrine and astrology. Therefore, historical handwritten palm leaf manuscripts are important for people who like to learn about historical documents, because we can learn more experience from them. This paper presents an image segmentation of historical handwriting from palm leaf manuscripts. The process is composed of three steps: 1) background elimination to separate text and background by Otsu's algorithm 2) line segmentation and 3) character segmentation by histogram of image. The end result is the character's image. The results from this research may be applied to optical character recognition (OCR) in the future.

  14. Membrane rejection of nitrogen compounds

    Science.gov (United States)

    Lee, S.; Lueptow, R. M.

    2001-01-01

    Rejection characteristics of nitrogen compounds were examined for reverse osmosis, nanofiltration, and low-pressure reverse osmosis membranes. The rejection of nitrogen compounds is explained by integrating experimental results with calculations using the extended Nernst-Planck model coupled with a steric hindrance model. The molecular weight and chemical structure of nitrogen compounds appear to be less important in determining rejection than electrostatic properties. The rejection is greatest when the Donnan potential exceeds 0.05 V or when the ratio of the solute radius to the pore radius is greater than 0.8. The transport of solute in the pore is dominated by diffusion, although convective transport is significant for organic nitrogen compounds. Electromigration contributes negligibly to the overall solute transport in the membrane. Urea, a small organic compound, has lower rejection than ionic compounds such as ammonium, nitrate, and nitrite, indicating the critical role of electrostatic interaction in rejection. This suggests that better treatment efficiency for organic nitrogen compounds can be obtained after ammonification of urea.

  15. The Earliest Acupuncture and Moxibustion Manuscript Was Found in Dunhuang

    Institute of Scientific and Technical Information of China (English)

    ZHAO Qi; Silke Assmus-Helfen

    2011-01-01

    @@ In 1900, around 50 000 books and manuscripts were discovered in the Mogao Grottoes of Dunhuang in Gansu Province, China.Known today as the "Dunhuang Heritage",this trove had been sealed in a cave for close on 900 years.Among the books, there was a volume entitled "New Compendium of Works on Moxibustion for Emergencies (新集备急灸经)".It is the earliest original manuscript for the collection of acupuncture papers at present and is particularly precious as not having been found recorded in any ancient books.

  16. Strategies for Using Plagiarism Software in the Screening of Incoming Journal Manuscripts: Recommendations Based on a Recent Literature Survey.

    Science.gov (United States)

    Lykkesfeldt, Jens

    2016-08-01

    In recent years, several online tools have appeared capable of identifying potential plagiarism in science. While such tools may help to maintain or even increase the originality and ethical quality of the scientific literature, no apparent consensus exists among editors on the degree of plagiarism or self-plagiarism necessary to reject or retract manuscripts. In this study, two entire volumes of published original papers and reviews from Basic & Clinical Pharmacology & Toxicology were retrospectively scanned for similarity in anonymized form using iThenticate software to explore measures to predictively identify true plagiarism and self-plagiarism and to potentially provide guidelines for future screening of incoming manuscripts. Several filters were applied, all of which appeared to lower the noise from irrelevant hits. The main conclusions were that plagiarism software offers a unique opportunity to screen for plagiarism easily but also that it has to be employed with caution as automated or uncritical use is far too unreliable to allow a fair basis for judging the degree of plagiarism in a manuscript. This remains the job of senior editors. Whereas a few cases of self-plagiarism that would not likely have been accepted with today's guidelines were indeed identified, no cases of fraud or serious plagiarism were found. Potential guidelines are discussed.

  17. An author’s guide to submission, revision and rejection

    Science.gov (United States)

    Smart, Pippa

    2015-01-01

    ‘Continuous effort, not strength or intelligence, is the key to understanding our potential.’ Winston Churchill The sting of rejection is nasty. However, when you get that letter (which you will), remember you will be in esteemed company. Many of us would like to publish in Science or Nature but what better revenge when they reject you than a Nobel Prize! This is exactly what happened to Hans Krebs, the biochemist who won the Nobel Prize in 1953 for discovering the citric acid cycle, commonly known as the Krebs cycle. Krebs submitted his findings to Nature but was faced with rejection. Never has Frank Sinatra’s famous quote been truer: ‘The best revenge is massive success.’ Nature has admitted to many other such faux pas in its publishing history and it is not unique in its misjudgements. Publishing is a game of risk-taking behaviour and strategy. Authors must convince editors and referees that their work is worthy of publishing. When journals do not publish this work, authors must remember the value of their manuscript and persist in finding it another home. JYOTI SHAH Commissioning Editor PMID:26492899

  18. Hypervigilance to Rejecting Stimuli in Rejection Sensitive Individuals: Behavioral and Neurocognitive Evidence.

    Science.gov (United States)

    Ehrlich, Katherine B; Gerson, Sarah A; Vanderwert, Ross E; Cannon, Erin N; Fox, Nathan A

    2015-10-01

    Individuals who are high in rejection sensitivity are vigilant toward social cues that signal rejection, and they exhibit attention biases towards information that confirms expectations of rejection. Little is known, however, about the neural correlates of rejection sensitivity. The present study examined whether rejection sensitivity is associated with individuals' neural responses to rejection-relevant information. Female participants, classified as high or average in rejection sensitivity, completed a modified dot-probe task in which a neutral face was paired with either another neutral face or a gaze-averted ("rejecting") face while EEG was collected and ERP components were computed. Behavioral results indicated that average rejection sensitive participants showed an attention bias away from rejecting faces, while high rejection sensitive participants were equally vigilant to neutral and rejecting faces. High rejection sensitivity was associated with ERP components signaling elevated attention and arousal to faces. These findings suggest that rejection sensitivity shapes behavioral and neurocognitive responses to faces.

  19. [Astrologic and medical manuscript of the 18th Century].

    Science.gov (United States)

    Kugener, Henri

    2010-01-01

    We present a manuscript from the 18th century, an extract taken from the "Great and the Little Albert" attributed to Albertus Magnus. The linguistic variety in the paper is typical for a text composed in Luxembourg. Added to this text are two incantations and a short cartomancy paper.

  20. Manuscripts and Rare Books in an Undergraduate Library.

    Science.gov (United States)

    Mortimer, Ruth

    1983-01-01

    Description of Smith College Library's Rare Book Room notes printed book and manuscript collections including the Sylvia Plath collection, Ernest Hemingway collection, and collection of modern press books. Related undergraduate courses in typography and the history of printing, student exhibitions, and student publications are highlighted. (EJS)

  1. Raman spectroscopic analysis of an important Visigothic historiated manuscript

    Science.gov (United States)

    Carter, Elizabeth A.; Perez, Fernando Rull; Garcia, Jesús Medina; Edwards, Howell G. M.

    2016-12-01

    Raman spectroscopy has been used to study fragments of early Visigothic historiated manuscripts from the important mediaeval library at Santo Domingo de Silos which were a part of a Beato dating from the tenth to the mid-eleventh centuries. These fragments are from some of the oldest manuscripts in the scriptorium of the monastery. In this study, a comparison is made between the pigments and inks used on these manuscripts and those used in a previous study of the unique Visigothic Beato de Valcavado in Santa Cruz, Valladolid, completed in the year 970, which is noted for its quality of execution as well as its content and is remarkable eschatologically in being identifiable as the complete work of only a single scribe. For comparative purposes, the pigments and inks used in the Silos Monastery Beato and a series of historiated early manuscripts from mediaeval times through to the Renaissance also held in the monastic library were analysed. Raman spectroscopy identified a range of mineral and organic pigments such as cinnabar, orpiment, minium, azurite and indigo. In addition, a number of admixtures were found, for example, indigo and orpiment to produce vergaut (green) and a mixture of cinnabar with iron-gall ink and cerussite to produce darker and lighter shades of red. Some interesting conclusions were drawn about the use of iron-gall and carbon-based inks. This article is part of the themed issue "Raman spectroscopy in art and archaeology".

  2. How to Review a Manuscript for "TEACHING Exceptional Children"

    Science.gov (United States)

    Ludlow, Barbara L.; Dieker, Lisa A.; Powell, Selma

    2014-01-01

    Professional journals are an integral component of information dissemination and professional development in the field of special education. Peer review of manuscripts submitted for consideration for publication in journals is the cornerstone of the professional review process, providing editors with advice about the value of the information…

  3. Moving an Initial Manuscript to Publication: Lessons Learned

    Science.gov (United States)

    Dangel, Julie Rainer; Fulton, Lori A.; Dana, Nancy Fichtman; Clift, Renee T.

    2012-01-01

    In this article the four coauthors share the process of moving a paper from a conference presentation to a manuscript that is acceptable for publication. The first two authors discuss the ways in which an experienced teacher educator mentored an emerging scholar through the submission process. The last two authors discuss the editors' role in…

  4. some reflections on the preservation of the Timbuktu manuscripts

    African Journals Online (AJOL)

    Ngulup

    A conference on Archives of Post-independence Africa and its Diaspora was .... The manuscripts and their covers demonstrate a sophisticated visual and technical ... Making a tabula rasa of Africa‟s intellectual history was one of the main ...

  5. Exploring Reviewer Reactions to Manuscripts Submitted to Academic Journals

    Science.gov (United States)

    Coniam, David

    2012-01-01

    This paper extends a previous study (Coniam, 2011) into a corpus of manuscript (MS) reviews conducted for the journal System by one reviewer in the eight-year period 2003-2011. The current paper highlights additional facets of the review process that focus on issues involving authors themselves. The study examines two related sets of research…

  6. The Law Review Manuscript Glut: The Need for Guidelines.

    Science.gov (United States)

    Jensen, Erik M.

    1989-01-01

    There are large numbers untenured law faculty, and that group must publish. However, authors are now sending out copies of each article to huge numbers of law reviews. Some guidelines are suggested, including, that one should have more than five copies of any manuscript circulating for consideration for publication. (MLW)

  7. Exploring Reviewer Reactions to Manuscripts Submitted to Academic Journals

    Science.gov (United States)

    Coniam, David

    2012-01-01

    This paper extends a previous study (Coniam, 2011) into a corpus of manuscript (MS) reviews conducted for the journal System by one reviewer in the eight-year period 2003-2011. The current paper highlights additional facets of the review process that focus on issues involving authors themselves. The study examines two related sets of research…

  8. OLD RUSSIAN MANUSCRIPTS IN THE RUSSIAN NATIONAL CORPUS

    Directory of Open Access Journals (Sweden)

    A. M. Moldovan

    2015-01-01

    Full Text Available The article deals with different types of the corpus representation of Old Russian manuscripts in their ability to solve linguistics problems. Collections of digital copies and e-books in PDF and DjVu formats are the simplest and widely spread type of electronic resources, containing old Russian manuscripts. Theoretically  more interesting, though much more difficult, is the representation  of digitized  editions as textual corpora and databases.  The main attention in the article is paid to the historical subcorpus within the Russian National Corpus representing the sources of the XI-XVII centuries and consisting of four parts: the Old Russian corpus, the Corpus of birchbark letters, the Middle Russian and the Church-Slavonic corpora.

  9. Manuscript Preparation, Submission and Features of the Electronic IBVS

    Science.gov (United States)

    Holl, A.

    IBVS is a small journal in the field of variable star research, which is fully electronic now. The HTML version of the journal features object database links and reference links. The necessary markup is provided by the authors, using the macros implemented in the LaTeX style file. We are testing a web-based manuscript submission tool, which would enable authors to submit data files, draw or upload simple figures, and enter plain ASCII or LaTeX text. The text is typeset on the server. The submitted manuscript can be previewed, and links tested by the authors themselves. The markup has been designed to facilitate automatic information exchange between the journal and databases. A short description is given on the other features of the electronic IBVS.

  10. Radiocarbon dating of medieval manuscripts from the University of Seville

    Energy Technology Data Exchange (ETDEWEB)

    Santos, F.J., E-mail: fsantos@us.e [Centro Nacional de Aceleradores (CNA), Avda. Thomas Alva Edison 7, Isla de la Cartuja, 41092 Seville (Spain); Gomez-Martinez, I.; Garcia-Leon, M. [Centro Nacional de Aceleradores (CNA), Avda. Thomas Alva Edison 7, Isla de la Cartuja, 41092 Seville (Spain)

    2010-04-15

    Eleven samples (parchment and paper) from different medieval manuscripts belonging to the cultural heritage of the University of Seville have been radiocarbon dated on the 1 MV AMS facility at the CNA in Seville (Spain). The objective of this study is double. First of all, these are the first real 'unknown' samples treated in the radiocarbon laboratory and dated on our AMS facility, SARA (Spanish Accelerator for Radionuclide Analysis). Besides, some useful information about the manuscripts can be obtained, either to corroborate the dates, or in some cases, to decide between possible dates. As expected, a general agreement is found between radiocarbon results and palaeographical data. Nevertheless, some interesting facts have been learned through this study. We present in this paper the procedure to prepare the samples and the ages obtained with a brief discussion of the results.

  11. How to write an article: Preparing a publishable manuscript!

    Science.gov (United States)

    Shidham, Vinod B; Pitman, Martha B; Demay, Richard M

    2012-01-01

    Most of the scientific work presented as abstracts (platforms and posters) at various conferences have the potential to be published as articles in peer-reviewed journals. This DIY (Do It Yourself) article on how to achieve that goal is an extension of the symposium presented at the 36(th) European Congress of Cytology, Istanbul, Turkey (presentation available on net at http://alturl.com/q6bfp). The criteria for manuscript authorship should be based on the ICMJE (International Committee of Medical Journal Editors) Uniform Requirements for Manuscripts. The next step is to choose the appropriate journal to submit the manuscript and review the 'Instructions to the authors' for that journal. Although initially it may appear to be an insurmountable task, diligent organizational discipline with a little patience and perseverance with input from mentors should lead to the preparation of a nearly perfect publishable manuscript even by a novice. Ultimately, the published article is an excellent track record of academic productivity with contribution to the general public good by encouraging the exchange of experience and innovation. It is a highly rewarding conduit to the personal success and growth leading to the collective achievement of continued scientific progress. Recent emergences of journals and publishers offering the platform and opportunity to publish under an open access charter provides the opportunity for authors to protect their copyright from being lost to conventional publishers. Publishing your work on this open platform is the most rewarding mission and is the recommended option in the current modern era.[This open access article can be linked (copy-paste link from HTML version of this article) or reproduced FREELY if original reference details are prominently identifiable].

  12. How to write an article: Preparing a publishable manuscript!

    Directory of Open Access Journals (Sweden)

    Vinod B Shidham

    2012-01-01

    Full Text Available Most of the scientific work presented as abstracts (platforms and posters at various conferences have the potential to be published as articles in peer-reviewed journals. This DIY (Do It Yourself article on how to achieve that goal is an extension of the symposium presented at the 36 th European Congress of Cytology, Istanbul, Turkey (presentation available on net at http://alturl.com/q6bfp. The criteria for manuscript authorship should be based on the ICMJE (International Committee of Medical Journal Editors Uniform Requirements for Manuscripts. The next step is to choose the appropriate journal to submit the manuscript and review the ′Instructions to the authors′ for that journal. Although initially it may appear to be an insurmountable task, diligent organizational discipline with a little patience and perseverance with input from mentors should lead to the preparation of a nearly perfect publishable manuscript even by a novice. Ultimately, the published article is an excellent track record of academic productivity with contribution to the general public good by encouraging the exchange of experience and innovation. It is a highly rewarding conduit to the personal success and growth leading to the collective achievement of continued scientific progress. Recent emergences of journals and publishers offering the platform and opportunity to publish under an open access charter provides the opportunity for authors to protect their copyright from being lost to conventional publishers. Publishing your work on this open platform is the most rewarding mission and is the recommended option in the current modern era. [This open access article can be linked (copy-paste link from HTML version of this article or reproduced FREELY if original reference details are prominently identifiable].

  13. Piety in pieces : how medieval readers customized their manuscripts

    OpenAIRE

    Rudy, Kathryn Margaret

    2016-01-01

    The University of St. Andrews Library Open Access Fund supported this Open Access publication. The Leverhulme Trust has generously contributed towards the research for this volume. Medieval manuscripts resisted obsolescence. Made by highly specialised craftspeople (scribes, illuminators, book binders) with labour-intensive processes using exclusive and sometimes exotic materials (parchment made from dozens or hundreds of skins, inks and paints made from prized minerals, animals and plants)...

  14. Research Workshop 2: How to Peer Review a Manuscript

    OpenAIRE

    Farrokh Habibzadeh

    2009-01-01

    "nObjectives: "nTo understand what “peer review” is "nWhat editors expect from reviewers "nHow to review a paper "nDo’s and Don’ts! "nHow to report your review "nPlan: "Peer review process is the cornerstone of evaluating the submitted manuscripts to biomedical journals. Considering the increasing trend in research publications in our country over the past decade, we witness establishment of new journals and higher num...

  15. On the identification of folium and orchil on illuminated manuscripts

    Science.gov (United States)

    Aceto, Maurizio; Calà, Elisa; Agostino, Angelo; Fenoglio, Gaia; Idone, Ambra; Porter, Cheryl; Gulmini, Monica

    2017-01-01

    The identification of the two purple dyes folium and orchil has rarely been reported in the analysis of painted artworks, especially when analysing illuminated manuscripts. This is not consistent with the fact that ancient literary sources suggested their use as substitutes for the more expensive Tyrian purple dye. By employing non-invasive spectroscopic techniques, the present work demonstrates that these dyes were actually widely used in the production of ancient manuscripts. By employing UV-visible diffuse reflectance spectrophotometry with optic fibres (FORS) and spectrofluorimetry, the abundant identification of both dyes on medieval manuscripts was performed by comparing the spectra recorded on ancient codices with those obtained on accurate replicas of dyed or painted parchment. Moreover, examples are also reported whereby the considered purple dyes were used in mixtures with other colourants. The overall information obtained here allowed us to define new boundaries for the time range in which orchil and folium dyes were used which is wider than previously thought, and to focus on their particular uses in the decoration of books.

  16. [The processes of manuscript evaluation and publication in Medicina Clínica. The editorial committee of Medicina Clínica].

    Science.gov (United States)

    Ribera, Josep M; Cardellach, Francesc; Selva, Albert

    2005-12-01

    The decision-making process includes a series of activities undertaken in biomedical journals from the moment a manuscript is received until it is accepted or rejected. Firstly, the manuscript is evaluated by the members of the Editorial Board, who analyze both its suitability for the journal and its scientific quality. After this initial evaluation, the article is evaluated by peer reviewers, an essential process to guarantee its scientific validity. Both the Editorial Board and the peer reviewers usually use checklists which are of enormous help in this task. Once the biomedical article has been accepted, the publication process is started, which in turn includes a series of steps, beginning with technical and medical review of the article's contents and ending with the article's publication in the journal. The present article provides a detailed description of the main technical and ethical issues involved in the processes of decision-making and publication of biomedical articles.

  17. 7 CFR 58.136 - Rejected milk.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Rejected milk. 58.136 Section 58.136 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Milk § 58.136 Rejected milk. A plant shall reject specific milk from a producer if the milk fails to...

  18. Peer Group Rejection and Children's Outgroup Prejudice

    Science.gov (United States)

    Nesdale, Drew; Durkin, Kevin; Maass, Anne; Kiesner, Jeff; Griffiths, Judith; Daly, Josh; McKenzie, David

    2010-01-01

    Two simulation studies examined the effect of peer group rejection on 7 and 9 year old children's outgroup prejudice. In Study 1, children (n = 88) pretended that they were accepted or rejected by their assigned group, prior to competing with a lower status outgroup. Results indicated that rejected versus accepted children showed increased…

  19. Text and illustration: the digitisation of a medieval manuscript.

    Science.gov (United States)

    Beavan, I; Arnott, M; McLaren, C

    1997-01-01

    This paper considers the choice of the medieval Aberdeen Bestiary as the first project in Aberdeen University Library's digitisation programme, and discusses some of the unusual features of the manuscript itself. Attention is given to the content and depth of the accompanying commentaries, and particular notice is paid to the nature and extent of the textual apparatus (translation and transcription). The factors influencing the choice of (a) PhotoCD as the image capture method, and (b) JPEG as the image format for transmission of the page images across the World Wide Web are examined. The importance of the Web design to the effectiveness of the overall resource is emphasised.

  20. Sweet Spots for Manuscripts: Visualizing the Quality of Scientific Production

    Directory of Open Access Journals (Sweden)

    Patricio Ramírez-Correa

    2015-08-01

    Full Text Available This study presents a visual approach to analyze scientific activity in indexed journals based on bibliometric indicators. The result of this analysis approach supports the process of choosing a journal to submit a manuscript, especially in knowledge domains where the author, whether novice or not, has failed to follow in detail the evolution of the domain. Moreover, the same approach can be used to an overall assessment of the production of researchers, research groups, institutions and countries. The conceptual foundations of the approach are volume and citation indicators of scientific journals articles. In particular, the proposed approach is based on SCImago Journal Rank index, the h-index and the annual number of articles published. The above indicators are transformed into percentiles and then displayed on a graph, integrating in this diagram the set of articles to be analyzed. The analysis approach was implemented in Sweet Spots for Manuscripts, online software based on open source components. As an example of its potential, an analysis of the 2014 research activity of the institutions belonging to the Council of Rectors of Chilean Universities is presented. Finally, the practical implications and opportunities for future research are discussed.

  1. Haunted manuscripts: ghost authorship in the medical literature.

    Science.gov (United States)

    Ngai, Stephanie; Gold, Jennifer L; Gill, Sudeep S; Rochon, Paula A

    2005-01-01

    Ghost authorship occurs when an individual who contributed substantially to a manuscript is not named in the byline or acknowledgments. Ghost authors may be employed by industry to prepare clinical trial results for publication. An expert is then "hired" as author so as to lend an air of credibility and neutrality to the manuscript. Ghost authorship is difficult to detect, and most articles that have been identified as ghostwritten were revealed as such only after investigative work by lawyers, journalists, or scientists. Ghost authorship is ethically questionable in that it may be used to mask conflicts of interest with industry. As it has been demonstrated that industry sponsorship of clinical trials may be associated with outcomes favorable to industry, this is problematic. Evidence-based medicine requires that clinical decisions be based on empirical evidence published in peer-reviewed medical journals. If physicians base their decisions on dubious research data, this can have negative consequences for patients. Ghost authorship also compromises academic integrity. A "film credit" concept of authority is one solution to the problems posed by ghost authorship. Other approaches have been taken by the United Kingdom and Denmark. A solution is necessary, as the relationship between authorship and accountability must be maintained.

  2. AAS Publishing News: Preparing Your Manuscript Just Got Easier

    Science.gov (United States)

    Kohler, Susanna

    2016-03-01

    Watermarking using the command watermark{DRAFT, v2}.Are you an astronomer considering submitting a paper to an AAS journal (i.e., AJ, ApJ, ApJ Letters, or ApJ Supplements)? If so, this post is for you! Read on to find out about the exciting new things you can do with the AASs newest LaTeX class file, available for download now.Why the Update?AAS publishing has maintained a consistent class file for LaTeX manuscript preparation for the past decade. But academic publishing is changing rapidly in todays era of electronic journals! Since its journals went fully electronic, the AAS has been continuously adding new publishing capabilities based on the recommendations of the Journals Task Force and the needs and requests of AAS authors. The AASs manuscript preparation tools are now being updated accordingly.Whats New in AASTex 6.0?There are many exciting new features and capabilities in AASTex 6.0. Here are just a few:Tracking options for author revisions include added{text}, deleted{text}, replaced{old}{new}, and explain{text}.Based on emulateapjDo you use the popular class file emulateapj to prepare your manuscripts? AASTex 6.0 is based on emulateapj, rather than on the older AASTex 5.2 (though 5.2 is still supported). This means that it is easy to produce a double-columned, single-spaced, and astro-ph-ready manuscript. Since two thirds of the AAS journals authors use emulateapj, this transition was designed to make manuscript preparation and sharing an easier and more seamless process.Tools for collaborationsDo you work in a large collaboration? AASTex now includes new tools to make preparing a manuscript within a collaboration easier. Drafts can now be watermarked to differentiate between versions. New markup for large author lists streamlines the display so that readers can access article information immediately, yet they can still access the full author list and affiliations at the end of the paper. And author revision markup allows members of a collaboration to

  3. Multiple blinded reviews of the same two manuscripts. Effects of referee characteristics and publication language.

    Science.gov (United States)

    Nylenna, M; Riis, P; Karlsson, Y

    1994-07-13

    To study the association between referee characteristics and their manuscript assessments, the influence of manuscript language on referees' judgments, and the usefulness, quality, and extent of referees' free-text comments. Two nonauthentic, but realistic, short manuscripts with a number of common methodological flaws were sent to 180 Scandinavian referees. Through randomization, each referee received one of the manuscripts in English and the other manuscript in the national language. A structured assessment of the manuscript quality was expressed on a 5-point scale, and the impact of referee characteristics (age, gender, experience, and so on) was analyzed by multiple linear regression. Manuscript quality assessed by referees. A total of 312 reviews from 156 referees could be used for the study of referee characteristics and language. With increasing experience, the referees gave lower quality scores (P referees' gender, specialty, or nationality was found. For the test manuscript of the poorest quality, the English version was assessed to be better than the national-language version (P referees. Only one referee mentioned the incorrect use of a parametric test in the analysis of data whose distribution was nonparametric. Experienced and young referees gave a stricter assessment of the manuscripts than their less experienced and older colleagues. An English version seemed to be accepted more easily than a national-language version of the same manuscript. Most referees spontaneously mentioned the shortcomings of the manuscripts only as part of their overall judgment.

  4. Survey on Inadequate and Omitted Citations in Manuscripts: A Precursory Study in Identification of Tasks for a Literature Review and Manuscript Writing Assistive System

    Science.gov (United States)

    Raamkumar, Aravind Sesagiri; Foo, Schubert; Pang, Natalie

    2016-01-01

    Introduction: This paper looks at the issue of inadequate and omitted citations in manuscripts by collecting the experiential opinions of researchers from the dual perspectives of manuscript reviewers and authors. Method: An online survey was conducted with participation from 207 respondents who had experience of reviewing and authoring research…

  5. Evaluating the SharedCanvas Manuscript Data Model in CATCHPlus

    CERN Document Server

    Sanderson, Robert; Albritton, Benjamin; Van de Sompel, Herbert

    2011-01-01

    In this paper, we present the SharedCanvas model for describing the layout of culturally important, hand-written objects such as medieval manuscripts, which is intended to be used as a common input format to presentation interfaces. The model is evaluated using two collections from CATCHPlus not consulted during the design phase, each with their own complex requirements, in order to determine if further development is required or if the model is ready for general usage. The model is applied to the new collections, revealing several new areas of concern for user interface production and discovery of the constituent resources. However, the fundamental information modelling aspects of SharedCanvas and the underlying Open Annotation Collaboration ontology are demonstrated to be sufficient to cover the challenging new requirements. The distributed, Linked Open Data approach is validated as an important methodology to seamlessly allow simultaneous interaction with multiple repositories, and at the same time to faci...

  6. [Regarding the Manuscript D " Dell' occhio " of Leonardo da Vinci].

    Science.gov (United States)

    Heitz, Robert F

    2009-01-01

    Leonardo da Vinci's Manuscript D consists of five double pages sheets, which, folded in two, comprise ten folios. This document, in the old Tuscan dialect and mirror writing, reveals the ideas of Leonardo on the anatomy of the eye in relation to the formation of images and visual perception. Leonardo explains in particular the behavior of the rays in the eye in terms of refraction and reflection, and is very mechanistic in his conception of the eye and of the visual process. The most significant innovations found in these folios are the concept of the eye as a camera obscura and the intersection of light rays in the interior of the eye. His texts nevertheless show hesitation, doubts and a troubled confusion, reflecting the ideas and uncertainties of his era. He did not share his results in his lifetime, despite both printing and etching being readily available to him.

  7. Linguistic terms describing different types of armour in Persian manuscripts

    Directory of Open Access Journals (Sweden)

    Moshtagh Khorasani, Manouchehr

    2011-12-01

    Full Text Available The present article investigates different terms describing armour and its diverse typology in Persian martial tradition taken from a selected number of 47 dated Persian manuscripts from the 10th to the 19th centuries C.E. Both human and animal armour used in battlefields are described.

    El presente artículo describe, a partir de 47 manuscritos persas datados entre el siglo X y el siglo XIX d.C., los diversos términos que han designado las armaduras y sus diversas tipologías en la tradición marcial persa, tanto en lo que se refiere a armaduras para hombres como aquellas elaboradas para los animales de batalla.

  8. Renal graft irradiation in acute rejection

    Energy Technology Data Exchange (ETDEWEB)

    Pilepich, M.V.; Sicard, G.A.; Breaux, S.R.; Etheredge, E.E.; Blum, J.; Anderson, C.B.

    1983-03-01

    To evaluate the effect of graft irradiation in the treatment of acute rejection of renal transplants, a randomized study was conducted from 1978 to 1981. Patients with acute rejection were given standard medical management in the form of intravenous methylprednisolone, and were chosen randomly to receive either graft irradiation (175 rads every other day, to a total of 525 rads) or simulated (sham) irradiation. Eighty-three rejections occurring in 64 grafts were randomized to the protocol. Rejection reversal was recorded in 84.5% of control grafts and 75% of the irradiated grafts. Recurrent rejections were more frequent and graft survival was significantly lower in the irradiated group (22%) than in the control group (54%). Graft irradiation does not appear to be beneficial in the treatment of acute rejection of renal transplants when used in conjunction with high-dose steroids.

  9. Renal allograft rejection: sonography and scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Singh, A.; Cohen, W.N.

    1980-07-01

    A total of 30 renal allograft patients who had sonographic B scanning and radionuclide studies of the transplant was studied as to whether: (1) the allograft rejection was associated with any consistent and reliable sonographic features and (2) the sonograms complemented the radionuclide studies. Focal areas of decreased parenchymal echogenicity were the most striking and consistent sonographic finding in chymal echogenicity were the most striking and consistens sonographic finding in allograft rejection. This was observed in most of the patients exhibiting moderate or severe rejection, but was frequently absent with mild rejection. Areas of decreased parenchymal echogenicity were not seen during episodes of acute tubular necrosis. Therefore, sonography showing zones of decreased parenchymal echogenicity was complementary to radionuclide studies in the diagnosis of allograft rejection versus acute tubular necrosis. Corticomedullary demarcation was difficult to interpret because of technical variables, and was inconsistently related to rejection in this series.

  10. Effect of nifedipine on renal transplant rejection.

    Science.gov (United States)

    Nicholson, M L; Dennis, M J; Beckingham, I J; Smith, S J

    1993-10-01

    The effect of early nifedipine therapy on acute renal allograft rejection was studied in 170 adult cadaveric transplant recipients. Acute rejection occurring in the first 3 months after transplantation was diagnosed by Tru-cut biopsy and the severity of each rejection episode assessed histologically. The incidence of acute rejection was significantly lower in patients treated with nifedipine (29 of 80; 36 per cent) than in controls (52 of 90; 58 per cent) (P nifedipine exerted a significant independent effect on the incidence of early acute rejection. Other factors identified in the multivariate model as influencing rejection were human leucocyte antigen (HLA) matching at the DR locus, blood level of cyclosporin during the first week, HLA matching at the B locus, donor age and donor sex. The 1-year graft survival rate was 88.6 per cent in patients given nifedipine and 63.8 per cent in controls (P nifedipine therapy has a useful role in human renal transplantation.

  11. An Iterative Rejection Sampling Method

    CERN Document Server

    Sherstnev, A

    2008-01-01

    In the note we consider an iterative generalisation of the rejection sampling method. In high energy physics, this sampling is frequently used for event generation, i.e. preparation of phase space points distributed according to a matrix element squared $|M|^2$ for a scattering process. In many realistic cases $|M|^2$ is a complicated multi-dimensional function, so, the standard von Neumann procedure has quite low efficiency, even if an error reducing technique, like VEGAS, is applied. As a result of that, many of the $|M|^2$ calculations go to ``waste''. The considered iterative modification of the procedure can extract more ``unweighted'' events, i.e. distributed according to $|M|^2$. In several simple examples we show practical benefits of the technique and obtain more events than the standard von Neumann method, without any extra calculations of $|M|^2$.

  12. Fractional active disturbance rejection control.

    Science.gov (United States)

    Li, Dazi; Ding, Pan; Gao, Zhiqiang

    2016-05-01

    A fractional active disturbance rejection control (FADRC) scheme is proposed to improve the performance of commensurate linear fractional order systems (FOS) and the robust analysis shows that the controller is also applicable to incommensurate linear FOS control. In FADRC, the traditional extended states observer (ESO) is generalized to a fractional order extended states observer (FESO) by using the fractional calculus, and the tracking differentiator plus nonlinear state error feedback are replaced by a fractional proportional-derivative controller. To simplify controller tuning, the linear bandwidth-parameterization method has been adopted. The impacts of the observer bandwidth ωo and controller bandwidth ωc on system performance are then analyzed. Finally, the FADRC stability and frequency-domain characteristics for linear single-input single-output FOS are analyzed. Simulation results by FADRC and ADRC on typical FOS are compared to demonstrate the superiority and effectiveness of the proposed scheme.

  13. Extended Active Disturbance Rejection Controller

    Science.gov (United States)

    Gao, Zhiqiang (Inventor); Tian, Gang (Inventor)

    2016-01-01

    Multiple designs, systems, methods and processes for controlling a system or plant using an extended active disturbance rejection control (ADRC) based controller are presented. The extended ADRC controller accepts sensor information from the plant. The sensor information is used in conjunction with an extended state observer in combination with a predictor that estimates and predicts the current state of the plant and a co-joined estimate of the system disturbances and system dynamics. The extended state observer estimates and predictions are used in conjunction with a control law that generates an input to the system based in part on the extended state observer estimates and predictions as well as a desired trajectory for the plant to follow.

  14. Therapeutic strategies for xenograft rejection.

    Science.gov (United States)

    Lin, S S

    2001-01-01

    The increasing demand for transplantable organs over the past several decades has stimulated the idea of using animal organs in lieu of cadaveric organs in clinical transplantation. Pigs are now considered to be the most suitable source of organs for transplantation because of their abundant availability, their appropriate size, their relatively short gestation period, and the recent development in the technology to genetically manipulate them. In the past few years, some of the seemingly complex immunologic responses in pig-to-primate transplantation have been elucidated. This progress has allowed us to focus our efforts on devising specific therapeutic strategies to overcome or prevent some of the responses that contribute to rejection of the xenograft. In this article, we review the various approaches that might allow clinical xenotransplantation to come to fruition.

  15. [Tubulointerstitial rejection of renal allografts].

    Science.gov (United States)

    Malušková, Jana; Honsová, Eva

    2015-01-01

    Tubulo-intersticial rejection represents T-cell mediated rejection of kidney allografts with the morphology of immune-mediated interstitial nephritis. Diagnosis is dependent on the histopathological evaluation of a graft biopsy sample. The key morphological features are interstitial inflammatory infiltrate and damage to tubular epithelial cell which in severe cases can result in the ruptures of the tubular basement membranes. The differential diagnosis of tubulo-interstitial rejection includes acute interstitial nephritis and viral inflammatory kidney diseases, mainly polyomavirus nephropathy.

  16. LATE RENAL GRAFT REJECTION: PATHOLOGY AND PROGNOSIS

    Directory of Open Access Journals (Sweden)

    E.S. Stolyarevich

    2014-01-01

    Full Text Available Rejection has always been one of the most important cause of late renal graft dysfunction. Aim of the study was to analyze the prevalence of different clinico-pathological variants of rejection that cause late graft dysfunction, and evaluate their impact on long-term outcome. Materials and methods. This is a retrospective study that analyzed 294 needle core biopsy specimens from 265 renal transplant recipients with late (48,8 ± 46,1 months after transplantation allograft dysfunction caused by late acute rejection (LAR, n = 193 or chronic rejection (CR, n = 78 or both (n = 23. C4d staining was performed by immunofl uorescence (IF on frozen sections using a standard protocol. Results. Peritubular capillary C4d deposition was identifi ed in 36% samples with acute rejection and in 62% cases of chronic rejection (including 67% cases of transplant glomerulopathy, and 50% – of isolated chronic vasculopathy. 5-year graft survival for LAR vs CR vs their combination was 47, 13 and 25%, respectively. The outcome of C4d– LAR was (p < 0,01 better than of C4d+ acute rejection: at 60 months graft survival for diffuse C4d+ vs C4d− was 33% vs 53%, respectively. In cases of chronic rejection C4d+ vs C4d– it was not statistically signifi cant (34% vs 36%. Conclusion. In long-term allograft biopsy C4d positivity is more haracteristic for chronic rejection than for acute rejection. Only diffuse C4d staining affects the outcome. C4d– positivity is associated with worse allograft survival in cases of late acute rejection, but not in cases of chronic rejection

  17. Piloting a National Programme for the Digitization of Medieval Manuscripts in Germany

    OpenAIRE

    2014-01-01

    An initiative to develop a concerted national programme for the digitization of medieval manuscripts in Germany was launched by five German manuscript centres in January 2013. This new proposal aims at the development of a master plan for the digitization of nearly all surviving medieval manuscripts in Germany and at the establishment of a new funding programme of the DFG (German Research Foundation), the largest research funding organization in Germany.Besides this fundamental financial aspe...

  18. Not all rejections are alike; competence and warmth as a fundamental distinction in social rejection

    NARCIS (Netherlands)

    Celik, P.; Lammers, J.; Beest, I. van; Bekker, M.H.J.; Vonk, R.

    2013-01-01

    Social rejection can lead to a variety of emotions. Two studies show that specific emotional reactions to social rejection can be understood by relying on the fundamental distinction between competence and warmth. Rejection that is perceived to be due to incompetence leads to anger, whereas

  19. An adaptive algorithm for noise rejection.

    Science.gov (United States)

    Lovelace, D E; Knoebel, S B

    1978-01-01

    An adaptive algorithm for the rejection of noise artifact in 24-hour ambulatory electrocardiographic recordings is described. The algorithm is based on increased amplitude distortion or increased frequency of fluctuations associated with an episode of noise artifact. The results of application of the noise rejection algorithm on a high noise population of test tapes are discussed.

  20. Renal allograft rejection. Unusual scintigraphic findings

    Energy Technology Data Exchange (ETDEWEB)

    Desai, A.G.; Park, C.H.

    1986-11-01

    During sequential renal imagining for evaluation of clinically suspected rejection, focal areas of functioning renal tissue were seen in two cases of renal transplant in the midst of severe and irreversible renal allograft rejection. A probable explanation for this histopathologically confirmed and previously unreported finding is discussed.

  1. On medieval manuscript production in the Latin West, explorations with a global database

    NARCIS (Netherlands)

    Buringh, E.

    2009-01-01

    This study is the first to present detailed information on the production and uses of manuscripts in eleven geographical areas, together comprising the Latin West. We estimated the absolute production (in numbers of manuscripts copied per century) in Europe between 500 and 1500. In total some eleven

  2. Analysis of Publication Decisions for "Journal of Research in Music Education" Manuscripts (2009-2014)

    Science.gov (United States)

    Sims, Wendy L.; Lordo, Jackie; Phelps, Cynthia Williams

    2016-01-01

    The primary purpose of this study was to investigate characteristics of manuscripts submitted to the "Journal of Research in Music Education" (JRME) representing various research methodologies. A database was compiled comprising all manuscripts that received a publication decision from February 2009 through March 2014 (N = 506). Only…

  3. Image-based historical manuscript dating using contour and stroke fragments

    NARCIS (Netherlands)

    He, Sheng; Samara, Petros; Burgers, Jan; Schomaker, Lambertus

    2016-01-01

    Historical manuscript dating has always been an important challenge for historians but since countless manuscripts have become digitally available recently, the pattern recognition community has started addressing the dating problem as well. In this paper, we present a family of local contour fragme

  4. Authorial or Scribal? : spelling variation in the Hengwrt and Ellesmere manuscripts of The Canterbury Tales

    NARCIS (Netherlands)

    Caon, Luigina Marina Domenica

    2009-01-01

    Chaucer’s Canterbury Tales has come down to us in about 80 fifteenth-century manuscripts, none of which is in his own hand. What is conventionally referred to as ‘Chaucer’s language’ is the language found in two early texts of The Canterbury Tales, the Hengwrt and the Ellesmere manuscripts. Despite

  5. Use of Citations within Manuscripts Published by the Journal of Agricultural Education

    Science.gov (United States)

    Estes, Hanna E.; Zimmerman, Bryan W.; Shoulders, Catherine W.; Johnson, Donald M.

    2014-01-01

    Because publications serve as the institutional memory of a discipline, researchers have the responsibility of becoming familiar with and acknowledging previous literature. The use of citations in manuscripts is considered ethical best practice, and is a method of manuscript evaluation. In agricultural education, researchers have recommended that…

  6. The Association of American Publishers' Electronic Manuscript Project: a status report.

    OpenAIRE

    Mehringer, A

    1986-01-01

    In July 1983, the Association of American Publishers (AAP) initiated the Electronic Manuscript Project, with the goal of an industry-wide standard and guidelines for electronic manuscript preparation. The project, viewed as a significant effort throughout the publishing and information communities, consists of six tasks designed to improve productivity and efficiency in publishing and to facilitate bibliographic processing.

  7. Keywords and Co-Occurrence Patterns in the Voynich Manuscript: An Information-Theoretic Analysis.

    Science.gov (United States)

    Montemurro, Marcelo A; Zanette, Damián H

    2013-01-01

    The Voynich manuscript has remained so far as a mystery for linguists and cryptologists. While the text written on medieval parchment -using an unknown script system- shows basic statistical patterns that bear resemblance to those from real languages, there are features that suggested to some researches that the manuscript was a forgery intended as a hoax. Here we analyse the long-range structure of the manuscript using methods from information theory. We show that the Voynich manuscript presents a complex organization in the distribution of words that is compatible with those found in real language sequences. We are also able to extract some of the most significant semantic word-networks in the text. These results together with some previously known statistical features of the Voynich manuscript, give support to the presence of a genuine message inside the book.

  8. The Constabulus manuscript in Durham Cathedral Library: A Forgotten Treasure?

    Directory of Open Access Journals (Sweden)

    Robinson, Maureen

    2005-06-01

    Full Text Available Johannes Hispalensis (John of Seville, working from Limia in Portugal and then Toledo in twelfth century Spain, translated mostly mathematical treatises from Arabic into Latin. His early work began in Limia with three medical translations c. 1118. One, the De differentia spiritus et animae originally bore the signature 'Johannes Hispalensis et Limiensis'. Not all scholars agree that this translator was Johannes Hispalensis. However, evidence supporting the theory that there was only one translator is provided by the De differentia, which resurfaced years later in a revised version dedicated to Raymond, Archbishop of Toledo from 1125 to 1152. It bore the shortened name: Johannes Hispalensis. An unknown copy of this revised version has been discovered in Durham Cathedral where it has lain dormant for 800 years. It contains a plethora of scribal mistakes, helping to prove that many of the inconsistencies between different copies of the same Latin manuscripts are due to human error rather than multiple identities working on the same translation.

    Johannes Hispalensis (Juan de Sevilla, que trabajó en Limia (Portugal y más tarde en Toledo, en la España del siglo XII, tradujo sobre todo tratados matemáticos del árabe al latín. Sus primeras obras comenzaron en Limia con tres traducciones sobre medicina alrededor del año 1118. Una de ellas, De differentia spiritus et animae, llevó originalmente la firma 'Johannes Hispalensis et Limiensis'. No todos los especialistas en esta época están de acuerdo en que este traductor fuera Johannes Hispalensis, Sin embargo, la obra De differentia aporta pruebas que apoyan la teoría de que hubo un único traductor. Dicha obra reapareció unos años más tarde en una versión revisada y dedicada a Raimundo, el Arzobispo de Toledo, entre 1125 y 1152. Llevaba el nombre abreviado: Johannes Hispalensis. Una copia desconocida de esta versión revisada fue hallada en la catedral de

  9. Self-compassion and rejection sensitivity

    OpenAIRE

    Hakan Saricam, Enes Ergun, Halis Sakiz

    2012-01-01

    Objectives: The purpose of this study is to examine the relationships between self-compassion and rejection sensitivity. Design: Self-compassion and are current concepts in social psychology and positive psychology. Preliminary evidence suggests that self-compassion is related to cognitive based social personality traits such as extraversion, social connectedness, self-determination, and feeling interpersonally connected to others. Also, rejection sensitivity is very important factor for inte...

  10. Structural Decoupling and Disturbance Rejection in a Distillation Column

    DEFF Research Database (Denmark)

    Bahar, Mehrdad; Jantzen, Jan; Commault, C.

    1996-01-01

    Introduction, distillation column model, input-output decoupling, disturbance rejection, concluding remarks, references.......Introduction, distillation column model, input-output decoupling, disturbance rejection, concluding remarks, references....

  11. Implementation and Outcomes of a Faculty-Based, Peer Review Manuscript Writing Workshop.

    Science.gov (United States)

    Kulage, Kristine M; Larson, Elaine L

    2016-01-01

    The publication of scholarly work and research findings is an important expectation for nursing faculty; however, academic writing is often neglected, leaving dissemination through manuscript writing an area of concern for the nursing profession. Writing initiatives have been utilized to promote scholarly dissemination in schools of nursing, but those described in the literature have been primarily non-United States based and student focused. This article describes a faculty-based manuscript writing workshop, assesses participants' impressions, and describes its impact on scholarly output. The workshop is a collaborative learning process utilizing peer review to improve manuscript quality and model behaviors for improving writing and peer-reviewing skills. Seventeen workshop participants including three predoctoral students, 6 postdoctoral fellows, and 8 faculty members completed an anonymous workshop survey (81% response rate). All but 1 of 17 manuscripts reviewed in the workshop are published, accepted, or in the review process. All participants indicated that the workshop was a valuable use of time and would recommend it to colleagues. The greatest reported workshop benefit was its function as an impetus to complete and submit manuscripts. We recommend the manuscript writing workshop model for other schools of nursing seeking ways to expand their scholarly output and create accountability for dissemination through manuscript writing.

  12. An Analysis of a Persian Archery manuscript written by Kapur Čand

    Directory of Open Access Journals (Sweden)

    Bede Dwyer

    2013-04-01

    Full Text Available The present article deals with an analysis of an undated Persian archery manuscript titled Resāle-ye Kamāndāri [Archery Manuscript] written by Kapur Čand. It is written in Persian and judging by the style it should have been written by a Persian. Persian archery manuscripts provide useful information on the usage of a contemporary Persian composite bow. First the article describes where the archery manuscript was found and collected. Then it describes the qualities of an archer in ten points. The next part of the article presents the characteristics of a Persian composite bow as described in the manuscript. Then the article discusses the suggested materials for making a bowstring. The next part of the manuscript deals with the materials used for making an arrow and useful information in the manuscript for bracing a Persian bow. The final part of the article explains different shooting techniques that can be used in shooting with a Persian composite bow.

  13. Bibliometric Analysis of the Most Cited First One Hundred Manuscripts in Familial Mediterranean Fever

    Directory of Open Access Journals (Sweden)

    Dilek Yılmaz

    2017-08-01

    Full Text Available Objective: Studies investigating cumulative scientific data about a specific subject and assessing the scientific performance are named as bibliometric analysis. Familial Mediterranean Fever (FMF is an autosomal recessive disease which is more prevalent among Turks, Jews, Armenians and Arabs. In this study, we aimed to analyse the most cited first 100 manuscripts in the field of FMF using bibliometric method. Materials and Methods: This study was performed retrospectively by using “Thomson Reuters Web of Science” database in April 2016. The dataset was filtered to include the manuscripts only in the scope of “Science Citation Index Expanded (SCI-E”. Furthermore, the first most cited 100 manuscripts were analyzed in terms of topic, journal, author, year and institution. Results: The database search returned 2027 manuscripts and the most cited first 100 papers were included. The most cited paper focused on genetics of FMF. Among these most cited 100 manuscripts, the study by Livneh had the highest volume of total citations with 1198. These most cited manuscripts were published in 44 journals. When these publications were evaluated in terms of countries, Israel had the most cited manuscripts with 37%, Turkey and USA with 18%, and France with 12%. Conclusion: This work provides the most influential references related to FMF and serves as a guide to what makes a publication citable. The genetics of FMF was the most widely studied topic and Israel, Turkey, USA and France were revealed as the arbiter countries of FMF topic.

  14. The textual transmission of the Castilian translation of the Divine Comedy (1515: From print to manuscript?

    Directory of Open Access Journals (Sweden)

    Cinthia M. Hamlin

    2013-12-01

    Full Text Available The first printed translation of the Divine Comedy (Burgos, 1515 is conserved in only one manuscript (HSA, B2183, which has hitherto been considered to be the source text used for its printing. This issue has not been the subject of much debate, possibly due to the lack of a thorough study of the manuscript and its textual transmission problems. In the present study we will try to discuss the assumed filiation between the manuscript and the printed version, through a collation of both testimonies that will focus on the manuscript’s emended verses as well as on the lexical and syntagmatic variants.

  15. Median Modes in the Light of the Greek Manuscript No. 9 from the National Archives in Drobeta Turnu Severin

    National Research Council Canada - National Science Library

    Adrian-Cristian Mazilita

    2015-01-01

    The Greek manuscript no. 9 from 1751 – a unique manuscript in Romania tells us more about the musical tradition of the Eastern Church, tradition which provided the unmodified safekeeping until today of the music and repertory that is an...

  16. Treatment of gout in a recently published 9th century manuscript of Rhazes.

    Science.gov (United States)

    Geronikolou, Styliani A

    2014-01-01

    Gout is a common lifestyle disease and was identified by Hippocrates in the fifth century BC although the condition was known ancient Egypt some two millennia earlier. The pharmaceutical suggestions described in a recently edited manuscript, the oldest known medical manuscript of the Arab world, is presented, here for the first time. It is entitled Treatise on Gout by Rhazes, the greatest of Arab clinicians, and was written in the late 9th or early 10th century. Rhazes' pharmaceutics are presented in descriptive tables and their components are also compared with other recipes from manuscripts of the Galen and a recently edited medieval Syrian manuscript of Le Livre des simples (Tables 1-2). It is noteworthy that Rhazes insists that the drugs should be taken before sunrise and at down, showing ignorance of current knowledge of circadian rhythms. This is of interest as arthritis chronotherapy is widely discussed in recent literature.

  17. Application of Threshold Techniques for Readability Improvement of Jawi Historical Manuscript Images

    CERN Document Server

    Som, Hafizan Mat; Ghazali, Amzari Jihadi; 10.5121/acij.2011.2206

    2011-01-01

    Historical documents such as old books and manuscripts have a high aesthetic value and highly appreciated. Unfortunately, there are some documents cannot be read due to quality problems like faded paper, ink expand, uneven colour tone, torn paper and other elements disruption such as the existence of small spots. The study aims to produce a copy of manuscript that shows clear wordings so they can easily be read and the copy can also be displayed for visitors. 16 samples of Jawi historical manuscript with different quality problems were obtained from The Royal Museum of Pahang, Malaysia. We applied three binarization techniques; Otsu's method represents global threshold technique; Sauvola and Niblack method which are categorized as local threshold techniques. We compared the binarized images with the original manuscript to be visually inspected by the museum's curator. The unclear features were marked and analyzed. Most of the examined images show that with optimal parameters and effective pre processing techn...

  18. A prototype system for handwritten sub-word recognition: Toward Arabic-manuscript transliteration

    CERN Document Server

    Moghaddam, Reza Farrahi; Milo, Thomas; Wisnovsky, Robert

    2011-01-01

    A prototype system for the transliteration of diacritics-less Arabic manuscripts at the sub-word or part of Arabic word (PAW) level is developed. The system is able to read sub-words of the input manuscript using a set of skeleton-based features. A variation of the system is also developed which reads archigraphemic Arabic manuscripts, which are dot-less, into archigraphemes transliteration. In order to reduce the complexity of the original highly multiclass problem of sub-word recognition, it is redefined into a set of binary descriptor classifiers. The outputs of trained binary classifiers are combined to generate the sequence of sub-word letters. SVMs are used to learn the binary classifiers. Two specific Arabic databases have been developed to train and test the system. One of them is a database of the Naskh style. The initial results are promising. The systems could be trained on other scripts found in Arabic manuscripts.

  19. How long is the peer review process for journal manuscripts? A case study on Angewandte Chemie International Edition.

    Science.gov (United States)

    Bornmann, Lutz; Daniel, Hans-Dieter

    2010-01-01

    One of the most frequently raised criticisms of the review process for manuscripts is that the length of time between submission of a manuscript and the editorial decision is overly long. Taking the journal Angewandte Chemie International Edition as an example and based on nearly 2000 manuscripts, the present study examined just how long the peer review process takes.

  20. Outlier Rejecting Multirate Model for State Estimation

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Wavelet transform was introduced to detect and eliminate outliers in time-frequency domain. The outlier rejection and multirate information extraction were initially incorporated by wavelet transform, a new outlier rejecting multirate model for state estimation was proposed. The model is applied to state estimation with interacting multiple model, as the outlier is eliminated and more reasonable multirate information is extracted, the estimation accuracy is greatly enhanced. The simulation results prove that the new model is robust to outliers and the estimation performance is significantly improved.

  1. Antimyosin imaging in cardiac transplant rejection

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, L.L.; Cannon, P.J. (Department of Medicine, College of Physicians and Surgeons, Columbia University, New York (United States))

    1991-09-01

    Fab fragments of antibodies specific for cardiac myosin have been labeled with indium-111 and injected intravenously into animals and into patients with heart transplants. The antibodies, developed by Khaw, Haber, and co-workers, localize in cardiac myocytes that have been damaged irreversibly by ischemia, myocarditis, or the rejection process. After clearance of the labeled antibody from the cardiac blood pool, planar imaging or single photon emission computed tomography is performed. Scintigrams reveal the uptake of the labeled antimyosin in areas of myocardium undergoing transplant rejection. In animal studies, the degree of antimyosin uptake appears to correlate significantly with the degree of rejection assessed at necropsy. In patients, the correlation between scans and pathologic findings from endomyocardial biopsy is not as good, possibly because of sampling error in the endomyocardial biopsy technique. The scan results at 1 year correlate with either late complications (positive) or benign course (negative). Current limitations of the method include slow blood clearance, long half-life of indium-111, and hepatic uptake. Overcoming these limitations represents a direction for current research. It is possible that from these efforts a noninvasive approach to the diagnosis and evaluation of cardiac transplantation may evolve that will decrease the number of endomyocardial biopsies required to evaluate rejection. This would be particularly useful in infants and children. 31 references.

  2. Partial interference subspace rejection in CDMA systems

    DEFF Research Database (Denmark)

    Hansen, Henrik; Affes, Sofiene; Mewelstein, Paul

    2001-01-01

    Previously presented interference subspace rejection (ISR) proposed a family of new efficient multiuser detectors for CDMA. We reconsider in this paper the modes of ISR using decision feedback (DF). DF modes share similarities with parallel interference cancellation (PIC) but attempt to cancel...

  3. Music genre recognition with risk and rejection

    DEFF Research Database (Denmark)

    Sturm, Bob L.

    2013-01-01

    We explore risk and rejection for music genre recognition (MGR) within the minimum risk framework of Bayesian classification. In this way, we attempt to give an MGR system knowledge that some misclassifications are worse than others, and that deferring classification to an expert may be a better...

  4. Ultrastructural basis of acute renal allograft rejection

    NARCIS (Netherlands)

    V.D. Vuzevski (Vojislav)

    1976-01-01

    textabstractAn attempt was made: I. to demonstrate the evolution and the time of onset of the ultrastructural morphological changes in the renal parenchyma and blood vessels, as well as the ultrastructural feature of the interstitial cellular infiltration in acute rejection of kidney allografts; 2.

  5. Waste heat rejection from geothermal power stations

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, R.C.

    1978-12-01

    This study of waste heat rejection from geothermal power stations is concerned only with the heat rejected from the power cycle. The heat contained in reinjected or otherwise discharged geothermal fluids is not included with the waste heat considered here. The heat contained in the underflow from the flashtanks in such systems is not considered as part of the heat rejected from the power cycle. By following this definition of the waste heat to be rejected, various methods of waste heat dissipation are discussed without regard for the particular arrangement to obtain heat from the geothermal source. Recent conceptual design studies made for 50-MW(e) geothermal power stations at Heber and Niland, California, are of particular interst. The former uses a flashed-steam system and the latter a binary cycle that uses isopentane. In last-quarter 1976 dollars, the total estimated capital costs were about $750/kW and production costs about 50 mills/kWhr. If wet/dry towers were used to conserve 50% of the water evaporation at Heber, production costs would be about 65 mills/kWhr.

  6. Double Ramp Loss Based Reject Option Classifier

    Science.gov (United States)

    2015-05-22

    Cao et al. (Eds.): PAKDD 2015, Part I, LNAI 9077, pp. 151–163, 2015. DOI: 10.1007/978-3-319-18038-0 12 152 N. Manwani et al. ρ is the parameter...A.: kernlab - an S4 package for kernel methods in R. Journal of Statistical Software 11(9), 1–20 ( 2004 ) Double Ramp Loss Based Reject Option

  7. Local graft irradiation in renal transplant rejection

    Energy Technology Data Exchange (ETDEWEB)

    Kawamura, Masashi; Kataoka, Masaaki; Itoh, Hisao (Ehime Univ., Matsuyama (Japan). School of Medicine)

    1990-04-01

    From 1977 to 1988, of 142 renal transplantations, seven recipients (4.9%) received local graft irradiation following rejective reaction refractory to antirejection medical managements. Concurrent with the administration of pulsed high dose methylprednisolone and other antirejection medical managements, the graft was irradiated with a total dose of 6.0 Gy-150 cGy per fraction every other day at the midplane of the graft using two opposing portals of 4MX Linac. The fields were defined by palpation and echography. All patients had improvements in serum creatinine on the 10th day after beginning the irradiation. Four patients with peripheral lymphocytosis during the irradiation combined with pulsed high dose methylprednisolone improved in renal functions. On the other hand, out of 3 patients with lymphcytopenic changes, in two the transplanted graft was removed due to deteriorations, and the other patient is currently suffering from chronic rejection. Local graft irradiation can be useful in maintaining a rejective graft and reversing its functions in some patients whose rejective reaction failed to respond to the antirejection medical managements. (author).

  8. Development of enhanced sulfur rejection processes

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, R.H.; Luttrell, G.H.; Adel, G.T.; Richardson, P.E.

    1996-03-01

    Research at Virginia Tech led to the development of two complementary concepts for improving the removal of inorganic sulfur from many eastern U.S. coals. These concepts are referred to as Electrochemically Enhanced Sulfur Rejection (EESR) and Polymer Enhanced Sulfur Rejection (PESR) processes. The EESR process uses electrochemical techniques to suppress the formation of hydrophobic oxidation products believed to be responsible for the floatability of coal pyrite. The PESR process uses polymeric reagents that react with pyrite and convert floatable middlings, i.e., composite particles composed of pyrite with coal inclusions, into hydrophilic particles. These new pyritic-sulfur rejection processes do not require significant modifications to existing coal preparation facilities, thereby enhancing their adoptability by the coal industry. It is believed that these processes can be used simultaneously to maximize the rejection of both well-liberated pyrite and composite coal-pyrite particles. The project was initiated on October 1, 1992 and all technical work has been completed. This report is based on the research carried out under Tasks 2-7 described in the project proposal. These tasks include Characterization, Electrochemical Studies, In Situ Monitoring of Reagent Adsorption on Pyrite, Bench Scale Testing of the EESR Process, Bench Scale Testing of the PESR Process, and Modeling and Simulation.

  9. Piloting a National Programme for the Digitization of Medieval Manuscripts in Germany

    Directory of Open Access Journals (Sweden)

    Claudia Fabian

    2014-08-01

    Full Text Available An initiative to develop a concerted national programme for the digitization of medieval manuscripts in Germany was launched by five German manuscript centres in January 2013. This new proposal aims at the development of a master plan for the digitization of nearly all surviving medieval manuscripts in Germany and at the establishment of a new funding programme of the DFG (German Research Foundation, the largest research funding organization in Germany.Besides this fundamental financial aspect, other objectives are the diffusion of technical standards and know-how to less experienced cultural heritage institutions and the creation of a nationwide network of competent partners, e.g. in the areas of digitization itself, long-term storage of digital data, the administration of persistent identifiers, and the internet presentation of digital collections. An important role will be played by the German manuscripts portal, Manuscripta Mediaevalia, which is intended as the central hub for both the presentation of digital collections of German manuscripts, but also of the relevant metadata, that is, digital and ideally searchable full-text versions of scholarly, in-depth manuscript descriptions. Of course, this centralization and aggregation will also facilitate the exchange of data with other institutions.The pilot phase will lead to the definition of a national digitization strategy with a clear prioritization of projects to be approached. It also aims at the creation of a sustainable technical infrastructure for the integration of both primary and secondary digital data. In this way, the current fragmentation of information in a plethora of local digitization projects is to be superseded by a unitary and complete virtual research environment for all those interested in medieval manuscripts from Germany.

  10. To Accept or Reject? The Impact of Adolescent Rejection Sensitivity on Early Adult Romantic Relationships.

    Science.gov (United States)

    Hafen, Christopher A; Spilker, Ann; Chango, Joanna; Marston, Emily S; Allen, Joseph P

    2014-03-01

    Successfully navigating entry into romantic relationships is a key task in adolescence, which sensitivity to rejection can make difficult to accomplish. This study uses multi-informant data from a community sample of 180 adolescents assessed repeatedly from age 16 to 22. Individuals with elevated levels of rejection sensitivity at age 16 were less likely to have a romantic partner at age 22, reported more anxiety and avoidance when they did have relationships, and were observed to be more negative in their interactions with romantic partners. In addition, females whose rejection sensitivity increased during late adolescence were more likely to adopt a submissive pattern within adult romantic relationships, further suggesting a pattern in which rejection sensitivity forecasts difficulties.

  11. Rejection sensitivity moderates the impact of rejection on self-concept clarity.

    Science.gov (United States)

    Ayduk, Ozlem; Gyurak, Anett; Luerssen, Anna

    2009-11-01

    Self-concept clarity (SCC) refers to the extent to which self-knowledge is clearly and confidently defined, internally consistent, and temporally stable. Research shows that SCC can be undermined by failures in valued goal domains. Because preventing rejection is an important self-relevant goal for people high in rejection sensitivity (RS), it is hypothesized here that failures to attain this goal would cause them to experience diminished SCC. Study 1, an experimental study, showed that high-RS people's SCC was undermined following rejection but not following an aversive experience unrelated to rejection. Study 2, a daily diary study of couples in relationships, used occurrence of partner conflicts to operationalize rejection. Replicating the findings in Study 1, having a conflict on any given diary day predicted a greater reduction in the SCC of high- compared to low-RS people on the following day. The implications for understanding the conditions under which rejection negatively affects the self-concept are discussed.

  12. Monitoring of Acute Rejection after Orthotopic Heart Tranplantation

    Institute of Scientific and Technical Information of China (English)

    Meng chun ying; Huang ke li; Luo bin; Wen ding guo

    2006-01-01

    Objectives To study the monitoring of rejection after orthotopic heart thansplantation.Methods From 1998 to 2005, 10 othotopic heart thansplans were performed, and acute rejection was monitored by endomyocardial biopsy as well as by clinical features, ECG, ultrasonocardiography and blood serum determination of Tropin I, and by the combination of these methods, we analysed the monitoring of acute rejection after the heart transplantation. Results With the combination of clinical features, ECG, ultrasonocardiography and blood serum test, 5 occurences of acute rejection were judged in the postoperative course, which were comfirmed by endomyocardial biopsy to be 2 acute rejections in Ⅰ b degree, 3 acute rejections in Ⅲ a degree. Endomyocardial biopsy were routinely performed 21 times postoperatively in which there were 1 acute rejection in Ⅰ a degree and 5 acute rejections in Ⅰ b degree. Conclusions Acute rejection is an important factor influencing the postoperative course of heart transplantation, so it is imperative to have an intime, effective and planned monitoring procedure for acute rejection. Endomyocardial biopsy is a sensitive and reliable method in diagnosis of acute rejection, but it is invasive and probable for some complications. The noninvasive method such as clinical features, ECG,ultrasonocardiography and blood serum test can be used as additive means in the diagnosis of acute rejection.Endomyocardial biopsy should be combined with some noninvasive methods in monitoring acute rejection after the heart transplantation.

  13. Chronic Kidney Isograft and Allograft Rejection

    Institute of Scientific and Technical Information of China (English)

    严群; 张鹏; 杨传永

    2002-01-01

    Summary: In this study antigen-independent factor in the pathogenesis of chronic rejection of organ transplants was examined. Kidney isografts and allografts were transplanted orthotopically into bilaterally nephroectomized rat recipients and studied functionally, morphologically and immunohistologically, at serial intervals up to 52 weeks after transplantation. Allograft recipients developed progressive proteinuria after 12 weeks, with gradual renal failure ultimately leading to death. At the same time, morphological changes, including progressive arteriosclerosis and glomerulosclerosis, tubular atrophy and interstitial fibrosis, developed. Immunohistologically, macrophages infiltrated glomeruli during this period and cytokines became unregulated. Our resuits showed that antigen-independent functional and morphological changes occurred in long-term kidney isografts and mimicked those appearing much earlier in allografts that reject chronically.Initial injury and extent of functioning renal mass is suggested to be important factor for such late changes.

  14. A new rejection of moral expertise.

    Science.gov (United States)

    Cowley, Christopher

    2005-01-01

    There seem to be two clearly-defined camps in the debate over the problem of moral expertise. On the one hand are the "Professionals", who reject the possibility entirely, usually because of the intractable diversity of ethical beliefs. On the other hand are the "Ethicists", who criticise the Professionals for merely stipulating science as the most appropriate paradigm for discussions of expertise. While the subject matter and methodology of good ethical thinking is certainly different from that of good clinical thinking, they argue, this is no reason for rejecting the possibility of a distinctive kind of expertise in ethics, usually based on the idea of good justification. I want to argue that both are incorrect, partly because of the reasons given by one group against the other, but more importantly because both neglect what is most distinctive about ethics: that it is personal in a very specific way, without collapsing into relativism.

  15. Interference Rejection Techniques in DSSS Communication System

    Institute of Scientific and Technical Information of China (English)

    GONGXiangyang; HUGuangrui

    2003-01-01

    It is known that the narrowband interfer-ence rejection capability of a direct sequence (DS) spread spectrum (SS) system can be enhanced considerably by an interference rejection algorithm prior to correlating it with the pseudo noise (PN) sequence. For narrowband gaussian noise (NGN), the techniques in common use are transver-sal filter. It models SS signal and NGN as stationary, then utilizes temporal correlation difference between SS signal and NBL however, SS signal and NGN are cyclostation-ary (CS). CS signal has correlation in frequency domain called spectrum correlation, which can not be employed by transversal filter. In this article, SS signal and NBIare modeled as CS and FRESH filter is adopted to exploit the correlation both in time domain and frequency domain.Computer simulation shows that FRESH filter can improve the system performance considerably compared with con-ventional transversal filter.

  16. The Cucurbitaceae and Solanaceae illustrated in medieval manuscripts known as the Tacuinum Sanitatis

    Science.gov (United States)

    Paris, Harry S.; Daunay, Marie-Christine; Janick, Jules

    2009-01-01

    Background and Aims Beginning in the last two decades of the 14th century, richly illuminated versions of the Tacuinum Sanitatis, the Latin translation of an 11th-century Arabic manuscript known as Taqwim al-Sihha bi al-Ashab al-Sitta, were produced in northern Italy. These illustrated manuscripts provide a window on late medieval life in that region by containing some 200 full-page illustrations, many of which vividly depict the harvest of vegetables, fruits, flowers, grains, aromatics and medicinal plants. Our objective was to search for and identify the images of taxa of Cucurbitaceae and Solanaceae. Methods We have located all reported illustrated Tacuinum Sanitatis and similar or related manuscripts, searched through printed or electronic reproductions of them, categorized six of them that display full-page illustrations as archetypic, and established the identity of the Cucurbitaceae and Solanaceae appearing in these six manuscripts. Key Results and Conclusions Of the Cucurbitaceae, Cucumis sativus (short-fruited cucumbers), Cucumis melo (including round as well as elongate melons), Citrullus lanatus (both sweet watermelons and citrons), and Lagenaria siceraria (including bottle-shaped as well as long gourds), are illustrated. Of the Solanaceae, Solanum melongena (egg-shaped purple aubergines) and Mandragora sp. (mandrake) are illustrated. These depictions include some of the earliest known images of cucumber, casaba melon (Cucumis melo Inodorous Group) and aubergine, each of which closely resembles an extant cultivar-group or market type. Overall, the botanically most accurate images are in the version of the Tacuinum located in the Österreichische Nationalbibliothek, Vienna, cod. ser. n. 2644. Similarities and differences in botanical accuracy among the images of Cucurbitaceae and Solanaceae in the six archetypal Tacuinum manuscripts suggest to us that another illustrated Tacuinum, now lost, may have antedated and served as a model or inspiration for the

  17. Internal Model Based Active Disturbance Rejection Control

    OpenAIRE

    Pan, Jinwen; Wang, Yong

    2016-01-01

    The basic active disturbance rejection control (BADRC) algorithm with only one order higher extended state observer (ESO) proves to be robust to both internal and external disturbances. An advantage of BADRC is that in many applications it can achieve high disturbance attenuation level without requiring a detailed model of the plant or disturbance. However, this can be regarded as a disadvantage when the disturbance characteristic is known since the BADRC algorithm cannot exploit such informa...

  18. Heterosexual Rejection and Mate Choice: A Sociometer Perspective.

    Science.gov (United States)

    Zhang, Lin; Liu, Shen; Li, Yue; Ruan, Lu-Jun

    2015-01-01

    Previous studies about the effects of social rejection on individuals' social behaviors have produced mixed results and tend to study mating behaviors from a static point of view. However, mate selection in essence is a dynamic process, and therefore sociometer theory opens up a new perspective for studying mating and its underlying practices. Based on this theory and using self-perceived mate value in the relationship between heterosexual rejection and mate choice as a mediating role, this current study examined the effects of heterosexual rejection on mate choice in two experiments. Results showed that heterosexual rejection significantly reduced self-perceived mate value, expectation, and behavioral tendencies, while heterosexual acceptance indistinctively increased these measures. Self-perceived mate value did not serve as a mediator in the relationship between heterosexual rejection and mate expectation, but it mediated the relationship between heterosexual rejection and mating behavior tendencies toward potential objects. Moreover, individuals evaded both rejection and irrelevant people when suffering from rejection.

  19. Education and training for implementation science: our interest in manuscripts describing education and training materials.

    Science.gov (United States)

    Straus, Sharon E; Sales, Anne; Wensing, Michel; Michie, Susan; Kent, Bridie; Foy, Robbie

    2015-09-28

    Alongside the growth in interest in implementation science, there has been a marked increase in training programs, educational courses, degrees, and other offerings in implementation research and practice to meet the demand for this expertise. We believe that the science of capacity building has matured but that we can advance it further by shining light on excellent work in this area and by highlighting gaps for future research. At Implementation Science, we regularly receive manuscripts that describe or evaluate training materials, competencies, and competency development in implementation curricula. We are announcing a renewed interest in manuscripts in this area, with specifications described below.

  20. Two Vienna Manuscript Atlases with Cartographic Representations of Croatian Cities from the 16th Century

    Directory of Open Access Journals (Sweden)

    Ivka Kljajić

    2007-05-01

    Full Text Available Two manuscript atlases (Cod. 8607 and Cod. 8609 from the Collection of Manuscripts, Documents and Heritage of the Austrian National Library (Handschriften-, Autographen- und Nachlass-Sammlung der Österreichischen Nationalbibliothek in Vienna are described. The time of acquisition of both atlases is reconstructed. Lists of all cartographic representations they contain are given for both atlases. The text found on the first sheet of the atlas Cod. 8609 is published for the first time in Croatia in the original form, in old German, as well as in Croatian translation. A comparison of these atlases is presented at the end.

  1. Research Article. An introduction to the edition of two Lemaître’s original manuscripts

    Directory of Open Access Journals (Sweden)

    Maere Catherine de

    2017-04-01

    Full Text Available The aim of this paper is to explain the contributions of G. Lemaître to Spinor Theory. At the end of the paper, we edited also, for the first time two short manuscripts: Spineurs et Quanta and Les spineurs et la physique quantique, written by Lemaître in December 1955 and in January 1956. This edition is a way of honouring Professor Michael Heller because he was the first, with Professor Odon Godart, who discovered, classified and published unedited manuscripts of G. Lemaître.

  2. Software workflow for the automatic tagging of medieval manuscript images (SWATI)

    Science.gov (United States)

    Chandna, Swati; Tonne, Danah; Jejkal, Thomas; Stotzka, Rainer; Krause, Celia; Vanscheidt, Philipp; Busch, Hannah; Prabhune, Ajinkya

    2015-01-01

    Digital methods, tools and algorithms are gaining in importance for the analysis of digitized manuscript collections in the arts and humanities. One example is the BMBF-funded research project "eCodicology" which aims to design, evaluate and optimize algorithms for the automatic identification of macro- and micro-structural layout features of medieval manuscripts. The main goal of this research project is to provide better insights into high-dimensional datasets of medieval manuscripts for humanities scholars. The heterogeneous nature and size of the humanities data and the need to create a database of automatically extracted reproducible features for better statistical and visual analysis are the main challenges in designing a workflow for the arts and humanities. This paper presents a concept of a workflow for the automatic tagging of medieval manuscripts. As a starting point, the workflow uses medieval manuscripts digitized within the scope of the project Virtual Scriptorium St. Matthias". Firstly, these digitized manuscripts are ingested into a data repository. Secondly, specific algorithms are adapted or designed for the identification of macro- and micro-structural layout elements like page size, writing space, number of lines etc. And lastly, a statistical analysis and scientific evaluation of the manuscripts groups are performed. The workflow is designed generically to process large amounts of data automatically with any desired algorithm for feature extraction. As a result, a database of objectified and reproducible features is created which helps to analyze and visualize hidden relationships of around 170,000 pages. The workflow shows the potential of automatic image analysis by enabling the processing of a single page in less than a minute. Furthermore, the accuracy tests of the workflow on a small set of manuscripts with respect to features like page size and text areas show that automatic and manual analysis are comparable. The usage of a computer

  3. What kind of alchemy is attested by tenth-century Coptic manuscripts?

    Science.gov (United States)

    Richter, Tonio Sebastian

    2009-03-01

    This article places the four extant Coptic alchemical manuscripts within the context of the tradition of Coptic scientific texts. One of the manuscripts is a palimpsest written over an erased literary text, apparently in the tenth century. The other three all come from the same library, and are unlikely to be later than the mid-tenth century. Their vocabulary, form and contents are analysed, and the wonderful "machine of the sages" is introduced. It is shown that the texts most likely depend on Arabic alchemical texts, because of the number of Arabic words left in transliteration, and their style. In this case, they are the earliest witnesses to Arabic alchemy.

  4. Scheduling Simple Linear Deteriorating Jobs with Rejection

    Directory of Open Access Journals (Sweden)

    Juan Zou

    2014-01-01

    Full Text Available We consider the problems of scheduling deteriorating jobs with release dates on a single machine (parallel machines and jobs can be rejected by paying penalties. The processing time of a job is a simple linear increasing function of its starting time. For a single machine model, the objective is to minimize the maximum lateness of the accepted jobs plus the total penalty of the rejected jobs. We show that the problem is NP-hard in the strong sense and presents a fully polynomial time approximation scheme to solve it when all jobs have agreeable release dates and due dates. For parallel-machine model, the objective is to minimize the maximum delivery completion time of the accepted jobs plus the total penalty of the rejected jobs. When the jobs have identical release dates, we first propose a fully polynomial time approximation scheme to solve it. Then, we present a heuristic algorithm for the case where all jobs have to be accepted and evaluate its efficiency by computational experiments.

  5. Active disturbance rejection controller for chemical reactor

    Energy Technology Data Exchange (ETDEWEB)

    Both, Roxana; Dulf, Eva H.; Muresan, Cristina I., E-mail: roxana.both@aut.utcluj.ro [Technical University of Cluj-Napoca, 400114 Cluj-Napoca (Romania)

    2015-03-10

    In the petrochemical industry, the synthesis of 2 ethyl-hexanol-oxo-alcohols (plasticizers alcohol) is of high importance, being achieved through hydrogenation of 2 ethyl-hexenal inside catalytic trickle bed three-phase reactors. For this type of processes the use of advanced control strategies is suitable due to their nonlinear behavior and extreme sensitivity to load changes and other disturbances. Due to the complexity of the mathematical model an approach was to use a simple linear model of the process in combination with an advanced control algorithm which takes into account the model uncertainties, the disturbances and command signal limitations like robust control. However the resulting controller is complex, involving cost effective hardware. This paper proposes a simple integer-order control scheme using a linear model of the process, based on active disturbance rejection method. By treating the model dynamics as a common disturbance and actively rejecting it, active disturbance rejection control (ADRC) can achieve the desired response. Simulation results are provided to demonstrate the effectiveness of the proposed method.

  6. THE DIAGNOSIS OF LIVER ALLOGRAFT ACUTE REJECTION IN LIVER BIOPSIES

    Directory of Open Access Journals (Sweden)

    L. V. Shkalova

    2011-01-01

    Full Text Available We performed histological examination of 80 liver allograft biopsies, the diagnosis of acute rejection was proved in 34 cases. Histological changes in liver biopsies in different grades of acute rejection were estimated according to Banff classification 1995, 1997 and were compared with current literature data. The article deals with the question of morphological value of grading acute rejection on early and late, also we analyze changes in treat- ment tactics after morphological verification of liver allograft acute rejection

  7. When Is Peer Rejection Justifiable? Children's Understanding across Two Cultures

    Science.gov (United States)

    Park, Yoonjung; Killen, Melanie

    2010-01-01

    This study investigated how Korean (N = 397) and U.S. (N = 333) children and adolescents (10 and 13 years of age) evaluated personality (aggression, shyness) and group (gender, nationality) characteristics as a basis for peer rejection in three contexts (friendship rejection, group exclusion, victimization). Overall, peer rejection based on…

  8. Parental Acceptance-Rejection Theory and the Phylogenetic Model.

    Science.gov (United States)

    Rohner, Ronald P.

    Guided by specific theoretical and methodological points of view--the phylogenetic perspective and the universalistic approach respectively--this paper reports on a worldwide study of the antecedents and effects of parental acceptance and rejection. Parental acceptance-rejection theory postulates that rejected children throughout our species share…

  9. Manuscript Cultures

    DEFF Research Database (Denmark)

    What do Mesoamerica, Greece, Byzantium, Island, Chad, Ethiopia, India, Tibet, China and Japan have in common? Like many other cultures of the world, they share a particular form of cultural heritage: ancient handwritten documents. In 2007, scholars from some20 countries around the world gathered...

  10. Retracted manuscript

    Science.gov (United States)

    Klockars, Anica

    2013-01-01

    The following article from Small GTPases, “Scientific Yellow Journalism” by Anica Klockars and Michael J. Williams, published online on 20 September 2012  (doi: 10.4161/sgtp.22289; http://www.landesbioscience.com/journals/smallgtpases/article/22289/) by Landes Bioscience and subsequently published in print in Small GTPases 2012 3(4):201 has been retracted by agreement between the authors and the journal’s Editor in Chief, Michael J. Williams (also an author of the paper).  PMID:23485921

  11. Common statistical and research design problems in manuscripts submitted to high-impact medical journals

    Directory of Open Access Journals (Sweden)

    Harris Alex HS

    2011-08-01

    Full Text Available Abstract Background To assist educators and researchers in improving the quality of medical research, we surveyed the editors and statistical reviewers of high-impact medical journals to ascertain the most frequent and critical statistical errors in submitted manuscripts. Findings The Editors-in-Chief and statistical reviewers of the 38 medical journals with the highest impact factor in the 2007 Science Journal Citation Report and the 2007 Social Science Journal Citation Report were invited to complete an online survey about the statistical and design problems they most frequently found in manuscripts. Content analysis of the responses identified major issues. Editors and statistical reviewers (n = 25 from 20 journals responded. Respondents described problems that we classified into two, broad themes: A. statistical and sampling issues and B. inadequate reporting clarity or completeness. Problems included in the first theme were (1 inappropriate or incomplete analysis, including violations of model assumptions and analysis errors, (2 uninformed use of propensity scores, (3 failing to account for clustering in data analysis, (4 improperly addressing missing data, and (5 power/sample size concerns. Issues subsumed under the second theme were (1 Inadequate description of the methods and analysis and (2 Misstatement of results, including undue emphasis on p-values and incorrect inferences and interpretations. Conclusions The scientific quality of submitted manuscripts would increase if researchers addressed these common design, analytical, and reporting issues. Improving the application and presentation of quantitative methods in scholarly manuscripts is essential to advancing medical research.

  12. Literary drafts, genetic criticism and computational technology. The Beckett Digital Manuscript Project

    NARCIS (Netherlands)

    Sichani, Anna-Maria

    2017-01-01

    This article addresses the Beckett Digital Manuscript Project, an evolving project, currently comprising a series of digital genetic editions of Samuel Beckett’s bilingual literary drafts and a digital library. Following the genetic school of editing, the project’s goal is to explore and represent

  13. Manuscript Editing as a Way of Teaching Academic Writing: Experience from a Small Scientific Journal

    Science.gov (United States)

    Misak, A.; Marusic, M.; Marusic, A.

    2005-01-01

    Medical writing and manuscript preparation are rarely taught in the context of undergraduate, graduate, or continuing medical education. As editors of a ''small'' medical scientific journal published in English in a non-native English-speaking (NNES) country, we hold that the knowledge of scientific methodology and specificities of scientific…

  14. Watermarks within the Middle Eastern Manuscript Collection of the Baillieu Library

    Science.gov (United States)

    Lewincamp, Sophie

    2012-01-01

    The University of Melbourne's Middle Eastern Manuscript collection housed at the Baillieu Library was acquired by Professor John Bowman in the 1950s as part of a teaching collection to promote greater learning of Middle Eastern culture and civilisation (Pryde 2007, 3). The collection is a rare example within Australia and represents many different…

  15. Student Peer Review Decisions on Submitted Manuscripts Are as Stringent as Faculty Peer Reviewers

    Science.gov (United States)

    Navalta, James W.; Lyons, T. Scott

    2010-01-01

    The "International Journal of Exercise Science" is the only student-centered peer-reviewed journal in its field. Upon graduate student first author submissions, two student reviewers and one faculty reviewer are asked to review. On professionally submitted papers, two faculty peers are asked to assess the manuscript. The purpose of the present…

  16. A core-item reviewer evaluation (CoRE) system for manuscript peer review.

    Science.gov (United States)

    Onitilo, Adedayo A; Engel, Jessica M; Salzman-Scott, Sherry A; Stankowski, Rachel V; Doi, Suhail A R

    2014-01-01

    Manuscript peer review is essential for ensuring accountability to all involved in the publication process, including authors, journals, and readers. Lack of consensus regarding what constitutes an accountable manuscript peer review process has resulted in varying practices from one journal to the next. Currently, reviewers are asked to make global judgments about various aspects of a paper for review irrespective of whether guided by a review checklist or not, and several studies have documented gross disagreement between reviewers of the same manuscript. We have previously proposed that the solution may be to direct reviewers to concrete items that do not require global judgments but rather provide a specific choice, along with referee justification for such choices. This study evaluated use of such a system via an international survey of health care professionals who had recently reviewed a health care--related manuscript. Results suggest that use of such a peer review system by reviewers does indeed improve interreviewer agreement, and thus, has the potential to support more consistent and effective peer review, if introduced into journal processes for peer review.

  17. A Comparison of Speed and Legibility of Manuscript and Cursive Handwriting of Intermediate Grade Pupils.

    Science.gov (United States)

    Jackson, Arthur Dale

    This study was designed to compare the speed and legibility of intermediate grade pupils' handwriting who have been instructed in two different styles of handwriting, manuscript and cursive. The subjects consisted of 108 intermediate grade pupils, boys and girls. Raw score data from the Otis Quick-Scoring Mental Ability Test, Beta Test: Form A,…

  18. D'Nealian and Zaner-Bloser Manuscript Alphabets and Initial Transition to Cursive Handwriting.

    Science.gov (United States)

    Trap-Porter, Jennifer; And Others

    1984-01-01

    A newly developed manuscript alphabet was compared with a traditional one to observe their effects on the teaching of cursive handwriting. Results showed no significant differences between the two types in teaching the production of cursive letters when presented to first graders. (Author/DF)

  19. The Effects of Manuscript-Cursive Combinations of Instructional Treatments on Spelling Achievement.

    Science.gov (United States)

    Bader, Lois Ann

    The purpose of this study was to compare the effects of four presentation-practice combinations of manuscript and cursive writing on the spelling achievement of fourth-grade subjects. Factors included in the investigation were initial spelling accuracy, visual memory and sex. The experimental subjects in the investigation were 120 fourth-grade…

  20. Evaluating the Difficulty of Cursive, Manuscript, Italic and D'Nealian Handwriting.

    Science.gov (United States)

    Duvall, Betty

    A study was conducted to establish a process for evaluating the difficulty of different handwritten letter forms. A criterion for calculating difficulty scores was delineated and four sets of letter forms were evaluated: manuscript, cursive, italic, and D'Nealian. Using the criterion, small letters were given a score of difficulty, the sum of…

  1. Comment on "How science survived: medieval manuscripts' 'demography' and classic texts' extinction".

    Science.gov (United States)

    Declercq, Georges

    2005-12-09

    Exciting though it may seem, the mathematical model developed by Cisne (Reports, 25 February 2005, p. 1305) to analyze the transmission of texts and manuscripts from Antiquity and the Middle Ages does not hold up to scrutiny. It seriously underestimates the losses, thus leading to conclusions that are unwarranted.

  2. On exemplary scientific conduct regarding submission of manuscripts to biomedical informatics journals

    NARCIS (Netherlands)

    R.A. Miller; T. Groth; A. Hasman; C. Safran; E.H. Shortliffe; R. Haux; A.T. McCray

    2006-01-01

    As the Editors of leading international biomedical informatics journals, the authors report on a recent pattern of improper manuscript submissions to journals in our field. As a guide for future authors, we describe ethical and pragmatic issues related to submitting work for peer-reviewed journal pu

  3. Identifying 16th-century paints on silver using a contemporary manuscript

    NARCIS (Netherlands)

    Davidowitz, T.; Beentjes, T.; van Bennekom, J.; Creange, S.; Eyb-Green, S.; Townsend, J.H.; Clarke, M.; Nadolny, J.; Kroustallis, S.

    2012-01-01

    The BnF Ms. Fr. 640 manuscript, written by an anonymous French goldsmith at the end of the 16th century, can be found in the collection of the Bibliothèque nationale de France in Paris. It describes the process of producing metal life-casts in great detail, from the preparation of the moulds to appl

  4. Household Scribes and the Production of Literary Manuscripts in Early Modern England

    Directory of Open Access Journals (Sweden)

    Marcy L. North

    2015-03-01

    Full Text Available In early modern English households, literate servants such as tutors, chaplains, stewards, secretaries, and ladies in waiting were well positioned to assist their employers in the assembly and copying of verse miscellanies, anthologies, and other literary manuscripts. Looking at several literary manuscripts, some with known servant contributions and others that suggest the participation of household retainers, the essay explores the likelihood that literate servants often performed scribal tasks above and beyond their formal job descriptions, even serving as scribe for their employers’ hobbies and leisure activities. Although copying was an arduous task, servants appear to have viewed these duties not simply as part of their job but also as gift exchanges, as appeals for promotion or patronage, and as a means by which they might gain access to manuscript literature and literary circles. Studies of early modern letter writing have called attention to many of the copy tasks of literate household servants, but the integral role of literate servants in the collection, copying, and preservation of literary manuscripts deserves much more attention.

  5. Reproducing crucible steel: a practical guide and a comparative analysis to persian manuscripts

    Directory of Open Access Journals (Sweden)

    Moshtagh Khorasani, Manouchehr

    2013-12-01

    Full Text Available Different terms are used in old Persian manuscripts, such as Ta’id Besârat, to define and refer to crucible or watered steel and different types of swords. However, there are few manuscripts that describe the way crucible steel cakes and blades were made such as the manuscript Gŏharnâme. The present article deals with the making of crucible steel as described in Persian manuscripts and also with a new reproduction process of making crucible steel as conducted by the Finnish smith Niko Hynninen.Los antiguos manuscritos persas, tales como Ta’id Besârat, emplean diversos términos para definir y referirse al acero de crisol o acero de Damasco y a diversos tipos de espada. Sin embargo, existen pocos manuscritos que describan el modo en que se elaboraban los lingotes y hojas de acero de crisol, entre ellos el manuscrito Gŏharnâme. El presente artículo describe el proceso de elaboración del acero de crisol tal y como lo refieren los manuscritos persas, así como una moderna reproducción del mismo realizada por el forjador finlandés Niko Hynninen.

  6. Strategies for Using Plagiarism Software in the Screening of Incoming Journal Manuscripts

    DEFF Research Database (Denmark)

    Lykkesfeldt, Jens

    2016-01-01

    opportunity to screen for plagiarism easily but also that it has to be employed with caution as automated or uncritical use is far too unreliable to allow a fair basis for judging the degree of plagiarism in a manuscript. This remains the job of senior editors. Whereas a few cases of self...

  7. Formatting Open Science: agilely creating multiple document formats for academic manuscripts with Pandoc Scholar

    Directory of Open Access Journals (Sweden)

    Albert Krewinkel

    2017-05-01

    Full Text Available The timely publication of scientific results is essential for dynamic advances in science. The ubiquitous availability of computers which are connected to a global network made the rapid and low-cost distribution of information through electronic channels possible. New concepts, such as Open Access publishing and preprint servers are currently changing the traditional print media business towards a community-driven peer production. However, the cost of scientific literature generation, which is either charged to readers, authors or sponsors, is still high. The main active participants in the authoring and evaluation of scientific manuscripts are volunteers, and the cost for online publishing infrastructure is close to negligible. A major time and cost factor is the formatting of manuscripts in the production stage. In this article we demonstrate the feasibility of writing scientific manuscripts in plain markdown (MD text files, which can be easily converted into common publication formats, such as PDF, HTML or EPUB, using Pandoc. The simple syntax of Markdown assures the long-term readability of raw files and the development of software and workflows. We show the implementation of typical elements of scientific manuscripts—formulas, tables, code blocks and citations—and present tools for editing, collaborative writing and version control. We give an example on how to prepare a manuscript with distinct output formats, a DOCX file for submission to a journal, and a LATEX/PDF version for deposition as a PeerJ preprint. Further, we implemented new features for supporting ‘semantic web’ applications, such as the ‘journal article tag suite’—JATS, and the ‘citation typing ontology’—CiTO standard. Reducing the work spent on manuscript formatting translates directly to time and cost savings for writers, publishers, readers and sponsors. Therefore, the adoption of the MD format contributes to the agile production of open science

  8. Dispositional mindfulness and rejection sensitivity: The critical role of nonjudgment.

    Science.gov (United States)

    Peters, Jessica R; Eisenlohr-Moul, Tory A; Smart, Laura M

    2016-04-01

    The pain of rejection is a crucial component of normal social functioning; however, heightened sensitivity to rejection can be impairing in numerous ways. Mindfulness-based interventions have been effective with several populations characterized by elevated sensitivity to rejection; however, the relationship between mindfulness and rejection sensitivity has been largely unstudied. The present study examines associations between rejection sensitivity and multiple dimensions of dispositional mindfulness, with the hypothesis that a nonjudgmental orientation to inner experiences would be both associated with decreased rejection sensitivity and attenuate the impact of sensitivity to rejection on general negative affect. A cross-sectional sample of undergraduates (n = 451) completed self-report measures of rejection sensitivity, dispositional mindfulness, and trait-level negative affect. Significant zero-order correlations and independent effects were observed between most facets of dispositional mindfulness and rejection sensitivity, with nonjudging demonstrating the largest effects. As predicted, rejection sensitivity was associated with negative affectivity for people low in nonjudging (β = .27, t = 5.12, p < .001) but not for people high in nonjudging (β = .06, t = .99, p = .324). These findings provide preliminary support for mindfulness, specifically the nonjudging dimension, as a protective factor against rejection sensitivity and its effects on affect.

  9. Using Compton scattering for random coincidence rejection

    Science.gov (United States)

    Kolstein, M.; Chmeissani, M.

    2016-12-01

    The Voxel Imaging PET (VIP) project presents a new approach for the design of nuclear medicine imaging devices by using highly segmented pixel CdTe sensors. CdTe detectors can achieve an energy resolution of ≈ 1% FWHM at 511 keV and can be easily segmented into submillimeter sized voxels for optimal spatial resolution. These features help in rejecting a large part of the scattered events from the PET coincidence sample in order to obtain high quality images. Another contribution to the background are random events, i.e., hits caused by two independent gammas without a common origin. Given that 60% of 511 keV photons undergo Compton scattering in CdTe (i.e. 84% of all coincidence events have at least one Compton scattering gamma), we present a simulation study on the possibility to use the Compton scattering information of at least one of the coincident gammas within the detector to reject random coincidences. The idea uses the fact that if a gamma undergoes Compton scattering in the detector, it will cause two hits in the pixel detectors. The first hit corresponds to the Compton scattering process. The second hit shall correspond to the photoelectric absorption of the remaining energy of the gamma. With the energy deposition of the first hit, one can calculate the Compton scattering angle. By measuring the hit location of the coincident gamma, we can construct the geometric angle, under the assumption that both gammas come from the same origin. Using the difference between the Compton scattering angle and the geometric angle, random events can be rejected.

  10. Why Goethe rejected Newton's theory of light.

    Science.gov (United States)

    Treisman, M

    1996-01-01

    Observations that he himself had made persuaded Goethe to reject Newton's theory of light and to put forward an alternative theory of the colour phenomena seen with a prism. Duck has argued that Goethe's attack on Newton's theory rested on valid experimental observations that appeared to present a difficulty for Newton's theory but to support his own views on colour. Duck has also proposed that these observations may be accounted for as an instance of the Bezold-Brücke phenomenon. It is argued here that this explanation is invalid and that two other features of colour processing can explain Goethe's observations.

  11. Confidence and rejection in automatic speech recognition

    Science.gov (United States)

    Colton, Larry Don

    Automatic speech recognition (ASR) is performed imperfectly by computers. For some designated part (e.g., word or phrase) of the ASR output, rejection is deciding (yes or no) whether it is correct, and confidence is the probability (0.0 to 1.0) of it being correct. This thesis presents new methods of rejecting errors and estimating confidence for telephone speech. These are also called word or utterance verification and can be used in wordspotting or voice-response systems. Open-set or out-of-vocabulary situations are a primary focus. Language models are not considered. In vocabulary-dependent rejection all words in the target vocabulary are known in advance and a strategy can be developed for confirming each word. A word-specific artificial neural network (ANN) is shown to discriminate well, and scores from such ANNs are shown on a closed-set recognition task to reorder the N-best hypothesis list (N=3) for improved recognition performance. Segment-based duration and perceptual linear prediction (PLP) features are shown to perform well for such ANNs. The majority of the thesis concerns vocabulary- and task-independent confidence and rejection based on phonetic word models. These can be computed for words even when no training examples of those words have been seen. New techniques are developed using phoneme ranks instead of probabilities in each frame. These are shown to perform as well as the best other methods examined despite the data reduction involved. Certain new weighted averaging schemes are studied but found to give no performance benefit. Hierarchical averaging is shown to improve performance significantly: frame scores combine to make segment (phoneme state) scores, which combine to make phoneme scores, which combine to make word scores. Use of intermediate syllable scores is shown to not affect performance. Normalizing frame scores by an average of the top probabilities in each frame is shown to improve performance significantly. Perplexity of the wrong

  12. USA: California rejects mandatory GMO labelling

    OpenAIRE

    PAULL, JOHN

    2012-01-01

    Buying organic remains the best strategy for US consumers to avoid eating GM food. The voters of California have rejected the proposal to label GMO food. The proposition was narrowly lost, 47% to 53% (4,326,770 ‘Yes’ votes vs. 4,884,961 ‘No’ votes). Proposition 47 was supported by the organic sector but opposed by a coalition of GMO companies and US multinational food companies. Californians were invited to vote into law ‘The California Right to Know Genetically Engineered Food Act’. Section ...

  13. Solar Rejection Filter for Large Telescopes

    Science.gov (United States)

    Hemmati, Hamid; Lesh, James

    2009-01-01

    To reject solar radiation photons at the front aperture for large telescopes, a mosaic of large transmission mode filters is placed in front of the telescope or at the aperture of the dome. Filtering options for effective rejection of sunlight include a smaller filter down-path near the focus of the telescope, and a large-diameter filter located in the front of the main aperture. Two types of large filters are viable: reflectance mode and transmittance mode. In the case of reflectance mode, a dielectric coating on a suitable substrate (e.g. a low-thermal-expansion glass) is arranged to reflect only a single, narrow wavelength and to efficiently transmit all other wavelengths. These coatings are commonly referred to as notch filter. In this case, the large mirror located in front of the telescope aperture reflects the received (signal and background) light into the telescope. In the case of transmittance mode, a dielectric coating on a suitable substrate (glass, sapphire, clear plastic, membrane, and the like) is arranged to transmit only a single wavelength and to reject all other wavelengths (visible and near IR) of light. The substrate of the large filter will determine its mass. At first glance, a large optical filter with a diameter of up to 10 m, located in front of the main aperture, would require a significant thickness to avoid sagging. However, a segmented filter supported by a structurally rugged grid can support smaller filters. The obscuration introduced by the grid is minimal because the total area can be made insignificant. This configuration can be detrimental to a diffraction- limited telescope due to diffraction effects at the edges of each sub-panel. However, no discernable degradation would result for a 20 diffraction-limit telescope (a photon bucket). Even the small amount of sagging in each subpanel should have minimal effect in the performance of a non-diffraction limited telescope because the part has no appreciable optical power. If the

  14. Antibody-Mediated Rejection: A Review

    Science.gov (United States)

    Garces, Jorge Carlos; Giusti, Sixto; Staffeld-Coit, Catherine; Bohorquez, Humberto; Cohen, Ari J.; Loss, George E.

    2017-01-01

    Background: Chronic antibody injury is a serious threat to allograft outcomes and is therefore the center of active research. In the continuum of allograft rejection, the development of antibodies plays a critical role. In recent years, an increased recognition of molecular and histologic changes has provided a better understanding of antibody-mediated rejection (AMR), as well as potential therapeutic interventions. However, several pathways are still unknown, which accounts for the lack of efficacy of some of the currently available agents that are used to treat rejection. Methods: We review the current diagnostic criteria for AMR; AMR paradigms; and desensitization, treatment, and prevention strategies. Results: Chronic antibody-mediated endothelial injury results in transplant glomerulopathy, manifested as glomerular basement membrane duplication, double contouring, or splitting. Clinical manifestations of AMR include proteinuria and a rise in serum creatinine. Current strategies for the treatment of AMR include antibody depletion with plasmapheresis (PLEX), immunoadsorption (IA), immunomodulation with intravenous immunoglobulin (IVIG), and T cell– or B cell–depleting agents. Some treatment benefits have been found in using PLEX and IA, and some small nonrandomized trials have identified some benefits in using rituximab and the proteasome inhibitor-based therapy bortezomib. More recent histologic follow-ups of patients treated with bortezomib have not shown significant benefits in terms of allograft outcomes. Furthermore, no specific treatment approaches have been approved by the US Food and Drug Administration. Other agents used for more difficult rejections include bortezomib and eculizumab (an anti-C5 monoclonal antibody). Conclusion: AMR is a fascinating field with ample opportunities for research and progress in the future. Despite the use of advanced techniques for the detection of human leukocyte antigen (HLA) or non-HLA donor-specific antibodies

  15. Uremic escape of renal allograft rejection

    Energy Technology Data Exchange (ETDEWEB)

    van Schilfgaarde, R. (Rijksuniversiteit Leiden (Netherlands). Academisch Ziekenhuis); van Breda Vriesman, P.J.C. (Rijksuniversiteit Limburg Maastricht (Netherlands). Dept. of Immunopathology)

    1981-10-01

    It is demonstrated in rats that, in the presence of early postoperative severe but transient uremia, the survival of first set Brown-Norway (BN) renal allografts in Lewis (LEW) recipients is at least three times prolonged when compared to non-uremic controls. This phenomenon is called 'uremic escape of renal allograft rejection'. By means of lethal X-irradiation of donors of BN kidneys transplanted into transiently uremic and non-uremic LEW recipients, the presence of passenger lymphocyte immunocompetence is demonstrated to be obilgatory for this phenomenon to occur. As a result of mobile passenger lymphocyte immunocompetence, a graft-versus-host (GVH) reaction is elicited in the spleens of LEW recipients of BN kidneys which amplifies the host response. The splenomegaly observed in LEW recipients of BN kidneys is caused not only by this GVH reaction, which is shown to be exquisitely sensitive to even mild uremia. It is also contributed to by a proliferative response of the host against the graft (which latter response is equated with an in vivo equivalent of a unilateral mixed lymphocyte reaction (MLR)), since the reduction in spleen weights caused by abrogation of mobile passenger lymphocyte immunocompetence brought about by lethal donor X-irradiation is increased significantly by early postoperative severe but transient uremia. It is concluded that in uremic escape of renal allograft rejection both reactions are suppressed by uremia during the early post-operative period.

  16. The heartbrake of social rejection: heart rate deceleration in response to unexpected peer rejection

    NARCIS (Netherlands)

    Gunther Moor, B.; Crone, E.A.; van der Molen, M.W.

    2010-01-01

    Social relationships are vitally important in human life. Social rejection in particular has been conceptualized as a potent social cue resulting in feelings of hurt. Our study investigated the psychophysiological manifestation of hurt feelings by examining the beat-by-beat heart rate response

  17. A Long Time Ago in a Library Far, Far Away ... The Adventures of the Gladiatoria Manuscript from New Haven

    Directory of Open Access Journals (Sweden)

    Hagedorn Dierk

    2015-05-01

    Full Text Available In this paper I will describe the adventurous history of an important late medieval German fechtbuch—a fighting manual—that belongs to a number of manuscripts known as the Gladiatoria group. In the beginning, the extent and the characteristics of this group of codices are explained; later on I will deal with one specific specimen that formerly belonged to a library in Germany—the Herzogliche Bibliothek in Gotha—from where it vanished during or after World War II. Until quite recently this manuscript was believed to be lost. I was able to identify a Gladiatoria manuscript from the Yale Center for British Art in New Haven, Connecticut, as that missing manuscript. The article presents a detailed description of the manuscript; it follows the path of the many places the codex passed through from the days of its creation until the present time; it offers a thorough line of argument that proves on one hand that the manuscript from New Haven is in fact identical to the one that disappeared from Gotha, and that verifies on the other hand an assumption by the renowned researcher Hans-Peter Hils that it is identical to yet another believed-to-be-lost manuscript that was sold by auction in Heidelberg in the 1950s and 1960s as single leaves; and finally it makes an attempt to reconstruct the original structure of the manuscript after it had been pulled apart.

  18. The role of CD8+ T cells during allograft rejection

    Directory of Open Access Journals (Sweden)

    Bueno V.

    2002-01-01

    Full Text Available Organ transplantation can be considered as replacement therapy for patients with end-stage organ failure. The percent of one-year allograft survival has increased due, among other factors, to a better understanding of the rejection process and new immunosuppressive drugs. Immunosuppressive therapy used in transplantation prevents activation and proliferation of alloreactive T lymphocytes, although not fully preventing chronic rejection. Recognition by recipient T cells of alloantigens expressed by donor tissues initiates immune destruction of allogeneic transplants. However, there is controversy concerning the relative contribution of CD4+ and CD8+ T cells to allograft rejection. Some animal models indicate that there is an absolute requirement for CD4+ T cells in allogeneic rejection, whereas in others CD4-depleted mice reject certain types of allografts. Moreover, there is evidence that CD8+ T cells are more resistant to immunotherapy and tolerance induction protocols. An intense focal infiltration of mainly CD8+CTLA4+ T lymphocytes during kidney rejection has been described in patients. This suggests that CD8+ T cells could escape from immunosuppression and participate in the rejection process. Our group is primarily interested in the immune mechanisms involved in allograft rejection. Thus, we believe that a better understanding of the role of CD8+ T cells in allograft rejection could indicate new targets for immunotherapy in transplantation. Therefore, the objective of the present review was to focus on the role of the CD8+ T cell population in the rejection of allogeneic tissue.

  19. The Palermo Merz Equatorial Telescope. An Instrument, a Manuscript, Some Drawings.

    Science.gov (United States)

    Chinnici, Ileana; Brenni, Paolo

    2015-01-01

    A manuscript by Georg and Sigmund Merz dated 1862 and containing instructions for assembling the equatorial telescope acquired by the Palermo Observatory is conserved in the archives of the Museo Astronomico e Copernicano in Rome. It is a rare document that reveals "tricks of the trade" and technical knowledge not usually included in textbooks or treatises. It was sent to the Palermo Observatory as an aid to the installation of the telescope, which made a signal contribution to the development of solar physics in Italy in the 19th century. Based on the study of unpublished sources (consisting of texts and drawings), the history of the instrument has been retraced. This paper presents a detailed description of the Merz manuscript (including a complete transcript) and some technical drawings recently discovered in the archives of the Palermo Observatory.

  20. "The Sky's Things", |xam Bushman 'Astrological Mythology' as recorded in the Bleek and Lloyd Manuscripts

    Science.gov (United States)

    Hollman, J. C.

    2007-07-01

    The Bleek and Lloyd Manuscripts are an extraordinary resource that comprises some 12 000 pages of |xam Bushman beliefs collected in the 1870s in Cape Town, South Africa. About 17% of the collection concerns beliefs and observations of celestial bodies. This paper summarises |xam knowledge about the origins of the celestial bodies as recorded in the manuscripts and situates this within the larger context of the |xam worldview. The stars and planets originate from a mythological past in which they lived as 'people' who hunted and gathered as the |xam did in the past, but who also had characteristics that were to make them the entities that we recognise today. Certain astronomical bodies have consciousness and supernatural potency. They exert an influence over people's everyday lives.

  1. Unsupervised categorization method of graphemes on handwritten manuscripts: application to style recognition

    Science.gov (United States)

    Daher, H.; Gaceb, D.; Eglin, V.; Bres, S.; Vincent, N.

    2012-01-01

    We present in this paper a feature selection and weighting method for medieval handwriting images that relies on codebooks of shapes of small strokes of characters (graphemes that are issued from the decomposition of manuscripts). These codebooks are important to simplify the automation of the analysis, the manuscripts transcription and the recognition of styles or writers. Our approach provides a precise features weighting by genetic algorithms and a highperformance methodology for the categorization of the shapes of graphemes by using graph coloring into codebooks which are applied in turn on CBIR (Content Based Image Retrieval) in a mixed handwriting database containing different pages from different writers, periods of the history and quality. We show how the coupling of these two mechanisms 'features weighting - graphemes classification' can offer a better separation of the forms to be categorized by exploiting their grapho-morphological, their density and their significant orientations particularities.

  2. Manuscript editing as a way of teaching academic writing: experience from a small scientific journal.

    Science.gov (United States)

    Misak, Aleksandra; Marusić, Matko; Marusić, Ana

    2006-01-01

    Medical writing and manuscript preparation are rarely taught in the context of undergraduate, graduate, or continuing medical education. As editors of a "small" medical scientific journal published in English in a non-native English-speaking (NNES) country, we hold that the knowledge of scinetific methodology and specificities of scientific reporting is a necessary precondition for a succesful scientific publication. Our experience shows that language professionals and translators whose services NNES authors use should be acquainted with the basic rules of scientific reporting. In this article we describe how each of the four layers of a manuscript -the study quality,the narrative, the scientific reporting style, and finally the language per se-can be improved.

  3. Young hands, old books: Drawings by children in a fourteenth-century manuscript, LJS MS. 361

    Science.gov (United States)

    Thorpe, Deborah Ellen

    2016-01-01

    This article scrutinises three marginal drawings in LJS 361, Kislak Center for Special Collections, Rare Books and Manuscripts, University of Pennsylvania Libraries. It first considers the provenance of the manuscript, questioning how it got into the hands of children. Then, it combines developmental psychology with close examination of the material evidence to develop a list of criteria to attribute the drawings to children. There is consideration of the features that help us estimate the age of the artists, and which indicate that one drawing was a collaborative effort between two children. A potential relationship is identified between the doodles and the subject matter of the text, prompting questions about pre-modern child education and literacy. Finally, the article considers the implications of this finding in both codicology and social history since these marginal illustrations demonstrate that children were active in the material life of medieval books. PMID:27517059

  4. OMR of early plainchant manuscripts in square notation: a two-stage system

    Science.gov (United States)

    Ramirez, Carolina; Ohya, Jun

    2011-01-01

    While Optical Music Recognition (OMR) of modern printed and handwritten documents is considered a solved problem, with many commercial systems available today, the OMR of ancient musical manuscripts still remains an open problem. In this paper we present a system for the OMR of degraded western plainchant manuscripts in square notation from the XIV to XVI centuries. The system has two main blocks, the first one deals with symbol extraction and recognition, while the second one acts as an error detection stage for the first block outputs. For symbol extraction we use widely known image-processing techniques, such as Sobel filtering and Hough Transform, and SVM for classification. The error detection stage is implemented with a hidden Markov model (HMM), which takes advantage of a priori knowledge for this specific kind of music.

  5. A practical guide to manuscript writing with particular relevance to the field of pediatric hospital medicine.

    Science.gov (United States)

    Teufel, Ronald J; Andrews, Anne L; Williams, Derek J

    2014-11-01

    Publishing manuscripts in peer-reviewed journals, such as Hospital Pediatrics, is critical for both the academic development of practitioners in pediatric hospital medicine and the scientific advancement of our field. Understanding the purpose of scientific writing and developing a structured approach to the writing process is essential. Doing so will improve the clarity of your work and likely the ease at which your research is published and disseminated throughout the scientific community. The purposes of this article are to detail the structure of a scientific manuscript, to highlight specific writing strategies, and to provide writing tips that may help or hinder publication. Our ultimate goal is to advance the field of pediatric hospital medicine and its growing membership by promoting the dissemination of high-quality research. Copyright © 2014 by the American Academy of Pediatrics.

  6. NINETEENTH-CENTURY MANUSCRIPTS OF THE CASTRO-PR: THE CASE OF RAISING

    OpenAIRE

    Dayme Rosane BENÇAL; Altino,Fabiane Cristina

    2015-01-01

    This study focuses on the alternations of mid vowels /e/ and /o/ in the pretonic context, respectively, present in the XIX century manuscripts belonging to Castro - Paraná. As this kind of oscillation, called raising, is not a recent process in the Portuguese language, we seek for evidences of Labov uniformitarianism when describing the cases found in XIX century formal documents in comparison to the data of orality, made available by Bisol (1981) Viegas (1987, 2001) Bortoni et. al (199...

  7. Prevention trumps treatment of antibody-mediated transplant rejection.

    Science.gov (United States)

    Knechtle, Stuart J; Kwun, Jean; Iwakoshi, Neal

    2010-04-01

    Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and insidious alloantibody-mediated graft injury. Half of heart transplant recipients develop chronic rejection within 10 years - a daunting statistic, particularly for young patients expecting to achieve longevity by enduring the rigors of a transplant. The current immunosuppressive pharmacopeia is relatively ineffective in preventing late alloantibody-associated chronic rejection. In this issue of the JCI, Kelishadi et al. report that preemptive deletion of B cells prior to heart transplantation in cynomolgus monkeys, in addition to conventional posttransplant immunosuppressive therapy with cyclosporine, markedly attenuated not only acute graft rejection but also alloantibody elaboration and chronic graft rejection. The success of this preemptive strike implies a central role for B cells in graft rejection, and this approach may help to delay or prevent chronic rejection after solid organ transplantation.

  8. Multivisceral transplantation in pigs: a clinicopathological analysis of tissue rejection.

    Directory of Open Access Journals (Sweden)

    Mitsuoka,Shintaro

    1995-10-01

    Full Text Available In this study, we established the surgical procedure and postoperative care of multivisceral transplantation (MVTX in pigs, and examined the functional changes and rejection pattern of transplanted organs in MVTX. Twenty-two MVTXs were performed without immunosuppression, and nine cases (41% that survived for 5 days or more after MVTX were used for evaluation. Rejection in grafts including the liver, pancreas, and gastrointestinal tract were assessed histopathologically. On day 5 after transplantation, the duodenum and small bowel already showed signs of mild rejection. On the other hand, in the liver, pancreas and stomach, rejection occurred later and was still mild on day 16. Hepatic rejection in MVTX appeared to occur later than in simple liver transplantation (LTX. These results showed that the susceptibility to rejection of individual visceral organs varies.

  9. The relations between secrecy, rejection sensitivity and autonomy-connectedness.

    Science.gov (United States)

    Wismeijer, Andreas A J; Van Assen, Marcel A L M; Bekker, Marrie H J

    2014-01-01

    The aim of this study was to examine the effects of two attachment-related variables on secrecy: rejection sensitivity and autonomy-connectedness. We hypothesized that rejection sensitivity is positively associated with secrecy, and autonomy-connectedness negatively with rejection sensitivity and secrecy. These hypotheses were generally corroborated in a sample of 303 university students. Moreover, we found that autonomy-connectedness at least partly explained the association between rejection sensitivity and secrecy. Self-awareness was negatively related to secrecy, suggesting that being aware of what one needs and thinks and being able to realize one's needs in social interactions reduce the tendency to keep secrets. In addition, interesting gender effects were found suggesting that men have a higher tendency to have secrets than women after controlling for the effects of autonomy-connectedness and rejection sensitivity. Our findings deepen the insight into possible reasons behind established associations between rejection sensitivity and secrecy, and may have clinical implications.

  10. The rejection-rage contingency in borderline personality disorder.

    Science.gov (United States)

    Berenson, Kathy R; Downey, Geraldine; Rafaeli, Eshkol; Coifman, Karin G; Paquin, Nina Leventhal

    2011-08-01

    Though long-standing clinical observation reflected in the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) suggests that the rage characteristic of borderline personality disorder (BPD) often appears in response to perceived rejection, the role of perceived rejection in triggering rage in BPD has never been empirically tested. Extending basic personality research on rejection sensitivity to a clinical sample, a priming-pronunciation experiment and a 21-day experience-sampling diary examined the contingent relationship between perceived rejection and rage in participants diagnosed with BPD compared with healthy controls. Despite the differences in these 2 assessment methods, the indices of rejection-contingent rage that they both produced were elevated in the BPD group and were strongly interrelated. They provide corroborating evidence that reactions to perceived rejection significantly explain the rage seen in BPD. © 2011 American Psychological Association

  11. The Visual Text: Bibliographic Codes as Pragmatic Markers on a Manuscript Page

    Directory of Open Access Journals (Sweden)

    Rogos-Hebda Justyna

    2016-12-01

    Full Text Available This paper explores the dynamics of the textual-visual interface of a medieval manuscript page within the frameworks of historical pragmatics and pragmaphilological approaches to the study of historical texts. Whilst the former focuses on the contexts in which historical utterances, manifested as texts, occur (Jacobs & Jucker 1995: 11, the latter involves a context-based perspective in the study of individual historical texts (Jucker 2000: 91. Combining the two approaches allows for a more comprehensive study of the “visual text” (cf. Machan 2011 than has been possible for paleographic, codicological, or linguistic analyses of medieval manuscripts. The present paper adopts the “pragmatics-on-the-page” approach (cf. Carroll et al. 2013, Peikola et al. 2014 in its analysis of bibliographic codes in British Library Royal MS 18 D II, which contains the texts of Lydgate’s Troy Book and Siege of Thebes. Such visual elements of the manuscript page as mise en page, ink colour, as well as type and size of script will be examined as pragmatic markers, functioning on three levels of meaning: textual, interactional, and metalinguistic (cf. Erman 2001, Carroll et al. 2013, and providing (visual contexts for interpreting the linguistic message of the text.

  12. “I myself am the author”: Gve Flaubert, or writer-manuscript

    Directory of Open Access Journals (Sweden)

    Yvan Leclerc

    2012-01-01

    Full Text Available The article attempts to present and discuss the juvenile works of Gustave Flaubert. Though the writer never allowed these juvenile works to be published, being extremely critical of their aesthetic value, the works such as November, Memoirs of a Madman or the diary-form Cahier intime de 1840–1841 still make important texts that provide a sizeable amount of information on the writer’s literary workshop. Interestingly enough, these early works show the writer’s attachment to the manuscript (tantamount to the dislike to the written word and the author’s tools (pen, ink and paper. These juvenile attempts, in the main autobiographical in nature, are thus penetrated by the metatext element that is a key input in providing an opportunity for a reflection on the way the text itself does exist: this element also informs us on Flaubert’s growing maturity that ultimately defined his role of a fully-fledged author. The paratext elements (epigraphs, dedications, inscriptions, dates and signatures in his juvenile works seem to be just as important as they allow us to follow, step by step, the way to the birth of a writer-manuscript and thus a writer who gets his fulfillment and the very existence exclusively in a text of a manuscript character.

  13. The Appreciation and Study of Qur’an Manuscripts from Southeast Asia: Past, Present, and Future

    Directory of Open Access Journals (Sweden)

    Annabel Teh Gallop

    2016-01-01

    Full Text Available The focus of this paper is not on theological aspects of the Qur’an, or on the study of the Qur’anic sciences in Southeast Asia over the past centuries, but rather to attempt to trace the path of the appreciation of old copies of the Qur’an in Southeast Asia as part of the historical record of the Islamic heritage of the region.  In this light, Qur’an manuscripts are viewed as objects of material culture which can cast light on the societies which produced them, and as works of art which testify to the heights of artistic creativity in the region, for illuminated Qur’an manuscripts represent the pinnacle of achievements in the arts of the book in Southeast Asia. This historical record can be measured through a survey of how, where, when and by whom Qur’an manuscripts in Southeast Asia were collected, documented, studied and published, both in Southeast Asia itself and in the west.

  14. A propaganda index for reviewing problem framing in articles and manuscripts: an exploratory study.

    Directory of Open Access Journals (Sweden)

    Eileen Gambrill

    Full Text Available OBJECTIVE: To determine the effectiveness of an index in increasing recognition of misleading problem framing in articles and manuscripts. DESIGN: A propaganda index consisting of 32 items was developed drawing on related literature. Seventeen subjects who review manuscripts for possible publication were requested to read five recent published reports of randomized controlled trials concerning social anxiety and to identify indicators of propaganda (defined as encouraging beliefs and actions with the least thought possible. They then re-read the same five articles using a propaganda index to note instances of propaganda. DATA SOURCE: Convenience sample of individuals who review manuscripts for possible publication and sample of recent published reports of randomized controlled trials regarding social anxiety in five different journals by different authors, blinded by author and journal. RESULTS: Data showed that there was a high rate of propagandistic problem framing in reports of RCTs regarding social anxiety such as hiding well argued alternative views and vagueness. This occurred in 117 out of 160 opportunities over five research reports. A convenience sample of 17 academics spotted only 4.5 percent of propaganda indicators. This increased to 64 percent with use of the 32 item propaganda index. Use of a propaganda index increased recognition of related indicators. However many instances remained undetected. CONCLUSION: This propaganda index warrants further exploration as a complement to reporting guidelines such as CONSORT and PRISMA.

  15. Organic dyes in illuminated manuscripts: a unique cultural and historic record

    Science.gov (United States)

    Melo, Maria João; Nabais, Paula; Guimarães, Maria; Araújo, Rita; Castro, Rita; Oliveira, Maria Conceição; Whitworth, Isabella

    2016-12-01

    In this study, we successfully addressed the challenges posed by the identification of dyes in medieval illuminations. Brazilwood pigment lakes and orcein purple colours were unequivocally identified in illuminated manuscripts dated by art historians to be from the thirteenth to the fifteenth centuries and in the Fernão Vaz Dourado Atlas (sixteenth century). All three works were on a parchment support. This was possible by combining Raman microscopy and surface-enhanced Raman spectroscopy with microspectrofluorimetry. To the best of our knowledge, this is the first time that brazilein, the main chromophore in brazilwood lake pigments, has been unequivocally identified by surface-enhanced Raman spectroscopy in an illuminated work (the Dourado Atlas). Complementing this identification, through microspectrofluorimetry and micro-Fourier transform infrared spectroscopy, it was possible to propose a complete paint formulation by comparison with our database of references; the dark pink hues, in the three case studies, were produced by combining brazilwood pigment lakes and gypsum in a protein- and gum arabic-based tempera. Orcein purple, also known as orchil dye, has been previously identified in medieval manuscripts, dated from the sixth to the ninth centuries. Our findings in fourteenth-sixteenth century manuscripts confirm the hypothesis that this dye was lost during the High Middle Ages, to be later rediscovered. This article is part of the themed issue "Raman spectroscopy in art and archaeology".

  16. Probing the statistical properties of unknown texts: application to the Voynich Manuscript.

    Science.gov (United States)

    Amancio, Diego R; Altmann, Eduardo G; Rybski, Diego; Oliveira, Osvaldo N; Costa, Luciano da F

    2013-01-01

    While the use of statistical physics methods to analyze large corpora has been useful to unveil many patterns in texts, no comprehensive investigation has been performed on the interdependence between syntactic and semantic factors. In this study we propose a framework for determining whether a text (e.g., written in an unknown alphabet) is compatible with a natural language and to which language it could belong. The approach is based on three types of statistical measurements, i.e. obtained from first-order statistics of word properties in a text, from the topology of complex networks representing texts, and from intermittency concepts where text is treated as a time series. Comparative experiments were performed with the New Testament in 15 different languages and with distinct books in English and Portuguese in order to quantify the dependency of the different measurements on the language and on the story being told in the book. The metrics found to be informative in distinguishing real texts from their shuffled versions include assortativity, degree and selectivity of words. As an illustration, we analyze an undeciphered medieval manuscript known as the Voynich Manuscript. We show that it is mostly compatible with natural languages and incompatible with random texts. We also obtain candidates for keywords of the Voynich Manuscript which could be helpful in the effort of deciphering it. Because we were able to identify statistical measurements that are more dependent on the syntax than on the semantics, the framework may also serve for text analysis in language-dependent applications.

  17. Non-destructive analysis for the investigation of decomposition phenomena of historical manuscripts and prints

    Science.gov (United States)

    Faubel, Werner; Staub, Susanne; Simon, Rolf; Heissler, Stefan; Pataki, Andrea; Banik, Gerhard

    2007-07-01

    As a contribution to the increasing efforts to preserve cultural heritage, historical books as well as illuminated manuscripts endangered by corrosive writing and printing materials or destructive coloring matters, non-destructive analytical methods are highly desirable enabling an in-situ examination of the surface status of an object. The development and application of a novel combination of non-destructive analytic methods based on (a) synchrotron radiation induced micro-X-ray fluorescence (SR-μXRF) and (b) Fourier transform infrared (FTIR) microscope allows to investigate the state as well as the effectiveness of conservation procedures for historical manuscripts. Examples of measurements include (1) an iron gall ink manuscript of a historical memo on legal land description of the year 1769, (2) an original hand colored herbal of the years 1536/38 from the Senckenbergische Bibliothek, Frankfurt, and (3) the incunabula Johannes von Saaz: "Der Ackermann aus Boehmen" fated from 1463 and printed by Albrecht Pfister, Bamberg, owned by the Herzog August Bibliothek, Wolfenbuettel.

  18. Non-destructive analysis for the investigation of decomposition phenomena of historical manuscripts and prints

    Energy Technology Data Exchange (ETDEWEB)

    Faubel, Werner [Institute for Technical Chemistry, Water-and Geotechnology Division, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe (Germany); Staub, Susanne [Institute for Synchrotron Radiation, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe (Germany); Simon, Rolf [Institute for Synchrotron Radiation, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe (Germany)], E-mail: Rolf.Simon@iss.fzk.de; Heissler, Stefan [Institute for Synchrotron Radiation, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe (Germany); Pataki, Andrea; Banik, Gerhard [State Academy of Art and Design Stuttgart, Department of Book and Paper Conservation , Hoehenstr. 16, 70736 Fellbach (Germany)

    2007-07-15

    As a contribution to the increasing efforts to preserve cultural heritage, historical books as well as illuminated manuscripts endangered by corrosive writing and printing materials or destructive coloring matters, non-destructive analytical methods are highly desirable enabling an in-situ examination of the surface status of an object. The development and application of a novel combination of non-destructive analytic methods based on (a) synchrotron radiation induced micro-X-ray fluorescence (SR-{mu}XRF) and (b) Fourier transform infrared (FTIR) microscope allows to investigate the state as well as the effectiveness of conservation procedures for historical manuscripts. Examples of measurements include (1) an iron gall ink manuscript of a historical memo on legal land description of the year 1769, (2) an original hand colored herbal of the years 1536/38 from the Senckenbergische Bibliothek, Frankfurt, and (3) the incunabula Johannes von Saaz: 'Der Ackermann aus Boehmen' fated from 1463 and printed by Albrecht Pfister, Bamberg, owned by the Herzog August Bibliothek, Wolfenbuettel.

  19. Linear quadratic output tracking and disturbance rejection

    Science.gov (United States)

    Karimi-Ghartemani, Masoud; Khajehoddin, S. Ali; Jain, Praveen; Bakhshai, Alireza

    2011-08-01

    This article introduces the problem of linear quadratic tracking (LQT) where the objective is to design a closed-loop control scheme such that the output signal of the system optimally tracks a given reference signal and rejects a given disturbance. Different performance indices that have been used to address the tracking problem are discussed and an appropriate new form is introduced. It is shown that a solution to the proposed optimality index exists under very mild conditions of stabilisability and detectability of the plant state-space equations. The solution is formulated based on converting the LQT problem to a standard linear quadratic regulation problem. The method is applied to two examples, a first-order plant and a third-order plant, and their simulation results are presented and discussed.

  20. Support vector machines with a reject option

    CERN Document Server

    Wegkamp, Marten; 10.3150/10-BEJ320

    2012-01-01

    This paper studies $\\ell_1$ regularization with high-dimensional features for support vector machines with a built-in reject option (meaning that the decision of classifying an observation can be withheld at a cost lower than that of misclassification). The procedure can be conveniently implemented as a linear program and computed using standard software. We prove that the minimizer of the penalized population risk favors sparse solutions and show that the behavior of the empirical risk minimizer mimics that of the population risk minimizer. We also introduce a notion of classification complexity and prove that our minimizers adapt to the unknown complexity. Using a novel oracle inequality for the excess risk, we identify situations where fast rates of convergence occur.

  1. Cytomegalovirus and chronic allograft rejection in liver transplantation

    Institute of Scientific and Technical Information of China (English)

    Liang-Hui Gao; Shu-Sen Zheng

    2004-01-01

    Cytomegalovirus (CMV) remains one of the most frequent viral infections and the most common cause of death after liver transplantation (LT). Chronic allograft liver rejection remains the major obstacle to long-term allograft survival and CMV infection is one of the suggested risk factors for chronic allograft rejection. The precise relationship between cytomegalovirus and chronic rejection remains uncertain.This review addresses the morbidity of cytomegalovirus infection and the risk factors associated with it, the relationship between cytomegalovirus and chronic allograft liver rejection and the potential mechanisms of it.

  2. Rejection Sensitivity, Jealousy, and the Relationship to Interpersonal Aggression.

    Science.gov (United States)

    Murphy, Anna M; Russell, Gemma

    2016-01-21

    The development and maintenance of interpersonal relationships lead individuals to risk rejection in the pursuit of acceptance. Some individuals are predisposed to experience a hypersensitivity to rejection that is hypothesized to be related to jealous and aggressive reactions within interpersonal relationships. The current study used convenience sampling to recruit 247 young adults to evaluate the relationship between rejection sensitivity, jealousy, and aggression. A mediation model was used to test three hypotheses: Higher scores of rejection sensitivity would be positively correlated to higher scores of aggression (Hypothesis 1); higher scores of rejection sensitivity would be positively correlated to higher scores of jealousy (Hypothesis 2); jealousy would mediate the relationship between rejection sensitivity and aggression (Hypothesis 3). Study results suggest a tendency for individuals with high rejection sensitivity to experience higher levels of jealousy, and subsequently have a greater propensity for aggression, than individuals with low rejection sensitivity. Future research that substantiates a link between hypersensitivity to rejection, jealousy, and aggression may provide an avenue for prevention, education, or intervention in reducing aggression within interpersonal relationships.

  3. Graft rejection after hematopoietic cell transplantation with nonmyeloablative conditioning

    DEFF Research Database (Denmark)

    Masmas, T.N.; Petersen, S.L.; Madsen, H.O.;

    2008-01-01

    -dose fludarabine and total body irradiation (TBI). The association of pretransplantation risk factors with rejection and the effect of chimerism and graft-versus-host disease on rejection were analyzed. Overall survival (OS) and progression free survival (PFS) were compared between patients with and without...... rejection. Retransplantation was performed with increased TBI conditioning for all patients, and with increased mycophenolate mofetil doses for recipients with HLA-identical sibling donors. No known pretransplantation risk factors were confirmed in this study. Rejection episodes were unevenly distributed...

  4. Corneal allograft rejection: Risk factors, diagnosis, prevention, and treatment

    Directory of Open Access Journals (Sweden)

    Dua Harminder

    1999-01-01

    Full Text Available Recent advances in corneal graft technology, including donor tissue retrieval, storage and surgical techniques, have greatly improved the clinical outcome of corneal grafts. Despite these advances, immune mediated corneal graft rejection remains the single most important cause of corneal graft failure. Several host factors have been identified as conferring a "high risk" status to the host. These include: more than two quadrant vascularisation, with associated lymphatics, which augment the afferent and efferent arc of the immune response; herpes simplex keratitis; uveitis; silicone oil keratopathy; previous failed (rejected grafts; "hot eyes"; young recipient age; and multiple surgical procedures at the time of grafting. Large grafts, by virtue of being closer to the host limbus, with its complement of vessels and antigen-presenting Langerhans cells, also are more susceptible to rejection. The diagnosis of graft rejection is entirely clinical and in its early stages the clinical signs could be subtle. Graft rejection is largely mediated by the major histocompatibility antigens, minor antigens and perhaps blood group ABO antigens and some cornea-specific antigens. Just as rejection is mediated by active immune mediated events, the lack of rejection (tolerance is also sustained by active immune regulatory mechanisms. The anterior chamber associated immune deviation (ACAID and probably, conjunctiva associated lymphoid tissue (CALT induced mucosal tolerance, besides others, play an important role. Although graft rejection can lead to graft failure, most rejections can be readily controlled if appropriate management is commenced at the proper time. Topical steroids are the mainstay of graft rejection management. In the high-risk situations however, systemic steroids, and other immunosuppressive drugs such as cyclosporin and tacrolimus (FK506 are of proven benefit, both for treatment and prevention of rejection.

  5. Median Modes in the Light of the Greek Manuscript No. 9 from the National Archives in Drobeta Turnu Severin

    Directory of Open Access Journals (Sweden)

    Adrian-Cristian Mazilita

    2015-10-01

    Full Text Available The Greek manuscript no. 9 from 1751 – a unique manuscript in Romania tells us more about the musical tradition of the Eastern Church, tradition which provided the unmodified safekeeping until today of the music and repertory that is an integral part of the cult of the Orthodox Church. Taking into account the importance of this manuscript for the musicological research of the ecclesiastical chant before the hrisantic reform, this study deals with different aspects from the old theory of Byzantine music, as: metrophony, solfeggio, median modes and trohos system.

  6. Saint Stephen’s martyrdom in three illuminated manuscripts of the Cistercian abbey of Alcobaça

    Directory of Open Access Journals (Sweden)

    Catarina Fernandes Barreira

    2016-12-01

    Full Text Available This article aims to analyse three representations of Saint Stephen that belong to three illuminated manuscripts produced by the scriptorium of the Cistercian abbey of Alcobaça in the 14th century. This study will combine the textual sources used to represent the saint and the importance that liturgical manuscripts from Alcobaça seem to attribute to him. It is also our intention to discuss the impact and the importance of the artistic circulation, but also Alcobaça’s identity in the three illuminated manuscripts.

  7. Prevalence and characteristics of foal rejection in Arabian mares.

    Science.gov (United States)

    Juarbe-Díaz, S V; Houpt, K A; Kusunose, R

    1998-09-01

    Separate surveys of Thoroughbred, Paint, and Arabian mare owners revealed a higher than expected rate of foal rejection in Arabian mares. A behavioural history form was submitted by owners of foal rejecting and nonrejecting Arabian mares, and maternal behaviour and management practices compared. Four generation pedigrees of rejecting and nonrejecting Arabian mares were also examined. Foal rejecting mares were more likely to avoid, threaten, squeal at, chase, bite, and kick their foals post partum than nonrejecting mares. Nonrejecting mares were more likely to lick, nicker and defend their foals post partum than rejecting mares. No statistically significant relationship was found between foal rejection and the type of breeding method (natural vs. artificial insemination), the presence of people at birth, the presence of nearby horses at birth, or assistance of the first nursing bout. The presence at least once of 1 of 2 related sires was statistically higher in the pedigrees of rejecting vs. nonrejecting mares. Inherited and learned or environmental factors are likely to affect the expression of foal rejection behaviour.

  8. 48 CFR 14.404-2 - Rejection of individual bids.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Rejection of individual... of individual bids. (a) Any bid that fails to conform to the essential requirements of the invitation... total price of the bid, but the prices for individual line items as well. (g) Any bid may be rejected...

  9. Heterosexual Rejection and Mate Choice: A Sociometer Perspective

    Directory of Open Access Journals (Sweden)

    Lin eZHANG

    2015-12-01

    Full Text Available Previous studies about the effects of social rejection on individuals’ social behaviors have produced mixed results and tend to study mating behaviors from a static point of view. However, mate selection in essence is a dynamic process, and therefore sociometer theory opens up a new perspective for studying mating and its underlying practices. Based on this theory and using self-perceived mate value in the relationship between heterosexual rejection and mate choice as a mediating role, this current study examined the effects of heterosexual rejection on mate choice in two experiments. Results showed that heterosexual rejection significantly reduced self-perceived mate value, expectation, and behavioral tendencies, while heterosexual acceptance indistinctively increased these measures. Self-perceived mate value did not serve as a mediator in the relationship between heterosexual rejection and mate expectation, but it mediated the relationship between heterosexual rejection and mating behavior tendencies towards potential objects. Moreover, individuals evaded both rejection and irrelevant people when suffering from rejection.

  10. 48 CFR 2919.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ... Small Business 2919.505 Rejecting Small Business Administration recommendations. When the SBA... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 2919.505 Section 2919.505 Federal Acquisition Regulations System DEPARTMENT...

  11. 48 CFR 1419.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ... Rejecting Small Business Administration recommendations. (a) A written justification in support of the CO's... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 1419.505 Section 1419.505 Federal Acquisition Regulations System DEPARTMENT...

  12. 48 CFR 219.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ...-Asides for Small Business 219.505 Rejecting Small Business Administration recommendations. (b) The... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 219.505 Section 219.505 Federal Acquisition Regulations System...

  13. 48 CFR 19.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ... Small Business Administration recommendations. (a) If the contracting officer rejects a recommendation... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 19.505 Section 19.505 Federal Acquisition Regulations System FEDERAL...

  14. Non-clairvoyant weighted flow time scheduling with rejection penalty

    DEFF Research Database (Denmark)

    Chan, Ho-Leung; Chan, Sze-Hang; Lam, Tak-Wah

    2012-01-01

    is defined as the weighted flow time of the job plus the penalty if it is rejected before completion. Previous work on minimizing the total user cost focused on the clairvoyant single-processor setting [BBC+03,CLL11] and has produced O(1)-competitive online algorithm for jobs with arbitrary weights...... algorithm has to decide job rejection and determine the order and speed of job execution. It is interesting to study the tradeoff between the above-mentioned user cost and energy. This paper gives two O(1)-competitive non-clairvoyant algorithms for minimizing the user cost plus energy on a single processor......This paper initiates the study of online scheduling with rejection penalty in the non-clairvoyant setting, i.e., the size (processing time) of a job is not assumed to be known at its release time. In the rejection penalty model, jobs can be rejected with a penalty, and the user cost of a job...

  15. Quantum Communication Using Coherent Rejection Sampling

    Science.gov (United States)

    Anshu, Anurag; Devabathini, Vamsi Krishna; Jain, Rahul

    2017-09-01

    Compression of a message up to the information it carries is key to many tasks involved in classical and quantum information theory. Schumacher [B. Schumacher, Phys. Rev. A 51, 2738 (1995), 10.1103/PhysRevA.51.2738] provided one of the first quantum compression schemes and several more general schemes have been developed ever since [M. Horodecki, J. Oppenheim, and A. Winter, Commun. Math. Phys. 269, 107 (2007); , 10.1007/s00220-006-0118-xI. Devetak and J. Yard, Phys. Rev. Lett. 100, 230501 (2008); , 10.1103/PhysRevLett.100.230501A. Abeyesinghe, I. Devetak, P. Hayden, and A. Winter, Proc. R. Soc. A 465, 2537 (2009), 10.1098/rspa.2009.0202]. However, the one-shot characterization of these quantum tasks is still under development, and often lacks a direct connection with analogous classical tasks. Here we show a new technique for the compression of quantum messages with the aid of entanglement. We devise a new tool that we call the convex split lemma, which is a coherent quantum analogue of the widely used rejection sampling procedure in classical communication protocols. As a consequence, we exhibit new explicit protocols with tight communication cost for quantum state merging, quantum state splitting, and quantum state redistribution (up to a certain optimization in the latter case). We also present a port-based teleportation scheme which uses a fewer number of ports in the presence of information about input.

  16. Acute Rejection after Human Renal Transplantation

    Directory of Open Access Journals (Sweden)

    Ana Roussoulières

    2007-01-01

    Full Text Available Genes involved in acute rejection (AR after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff-graded transplant biopsies were examined for the presence of VE-Cadherin and CD34 staining by immunohistochemistry (no AR (n=5, AR grade IA (n=5, or AR grade IIA (n=5. Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference in CD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in AR Grade IIA when compared to no AR (P=.01 and to AR grade IA (P=.02. This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR.

  17. How rejection of essences expresses despair.

    Science.gov (United States)

    Tougas, C T

    1999-07-01

    The Self and the ego in Jung's psychology are an instance of what Edmund Husserl called a 'double intentionality': one tending toward meaning is distinct from another tending toward meaning, yet they are reciprocally inseparable from each other. As perception in a present moment and memory of a past are impossible without each other, so an intending of ego and that of Self are impossible without each other. Accompanying the ego (mostly in the background) during each moment of time is a tending towards a particular Idea or essence. This reciprocity is expressed in a unique way over a lifetime and is like the relation of mother and child, and so it is important for all of us born of women to retain a sense of essences and the fullness of Self. 'Constructivism', however, is a current belief held by some feminists, and it influences both theorizing and practice in analytical psychology. It involves a rejection of essences, a revision of Jung's Idea of Self, and an attempt to conduct analysis without reference to an intentional subjective Self. Such constructivist revision expresses a despair both about essences as Ideas and about Self as intentional and subjective. It is despair over Self in a Kierkegaardian sense.

  18. Alpha Background Rejection in Bolometer Detectors

    Science.gov (United States)

    Deporzio, Nicholas

    2016-03-01

    This study presents the modification of bolometer detectors used in particle searches to veto or otherwise reject alpha radiation background and the statistical advantages of doing so. Several techniques are presented in detail - plastic film scintillator vetoes, metallic film ionization vetoes, and scintillating bolometer vetoes. Plastic scintillator films are cooled to bolometer temperatures and bombarded with 1.4MeV to 6.0MeV alpha particles representative of documented detector background. Photomultipliers detect this scintillation light and produce a veto signal. Layered metallic films of a primary metal, dielectric, and secondary metal, such as gold-polyethylene-gold films, are cooled to milli-kelvin temperatures and biased to produce a current signal veto when incident 1.4MeV to 6.0MeV alpha particles ionize conduction paths through the film. Modified Zinc Molybdate Bolometers are used to produce scintillation light when stimulated by alpha background. Calibration of veto signal to background energy is presented. Results are used to quantify the statistical impact of such modifications on bolometer searches.

  19. Ferrite grade iron oxides from ore rejects

    Indian Academy of Sciences (India)

    K S Rane; V M S Verenkar; P Y Sawant

    2001-06-01

    Iron oxyhydroxides and hydroxides were synthesized from chemically beneficiated high SiO2/Al2O3 low-grade iron ore (57.49% Fe2O3) rejects and heated to get iron oxides of 96–99.73% purity. The infrared band positions, isothermal weight loss and thermogravimetric and chemical analysis established the chemical formulas of iron-oxyhydroxides as -FeOOH.0.3H2O; -FeOOH.0.2H2O and amorphous FeOOH. The thermal products of all these were -Fe2O3 excepting that of -FeOOH.0.3H2O which gave mainly -Fe2O3 and some admixture of -Fe2O3. The hydrazinated iron hydroxides and oxyhydroxides, on the other hand, decomposed autocatalytically to mainly -Fe2O3. Hydrazine method modifies the thermal decomposition path of the hydroxides. The saturation magnetization, s, values were found to be in the range 60–71 emu g–1 which are close to the reported values for -Fe2O3. Mechanism of the -Fe2O3 formation by hydrazine method is discussed.

  20. Background Assay and Rejection in DRIFT

    CERN Document Server

    Brack, Jeff; Dorofeev, Alexei; Ezeribe, Anthony; Gauvreau, Jean-Luc; Gold, Michael; Harton, John; Lafler, Randy; Lauer, Robert; Lee, Eric R; Loomba, Dinesh; Matthews, John; Miller, Eric H; Monte, Alissa; Murphy, Alex; Paling, Sean; Phan, Nguyen; Sadler, Steve; Scarff, Andrew; Snowden-Ifft, Daniel; Spooner, Neil; Telfer, Sam; Walker, Daniel; Williams, Matt; Yuriev, Leonid

    2014-01-01

    The DRIFT-IId dark matter detector is a m$^3$-scale low-pressure TPC with directional sensitivity to WIMP-induced nuclear recoils. Its primary backgrounds were due to alpha decays from contamination on the central cathode. Efforts to reduce these backgrounds led to replacing the 20 \\mu m wire central cathode with one constructed from 0.9 \\mu m aluminized mylar, which is almost totally transparent to alpha particles. Detailed modeling of the nature and origin of the remaining backgrounds led to an in-situ, ppt-sensitive assay of alpha decay backgrounds from the central cathode. This led to further improvements in the thin-film cathode resulting in over 2 orders of magnitude reduction in backgrounds compared to the wire cathode. Finally, the addition of O$_2$ to CS$_2$ gas was found to produce multiple species of electronegative charge carriers, providing a method to determine the absolute position of nuclear recoils and reject all known remaining backgrounds while retaining a high efficiency for nuclear recoil...

  1. South African court rejects country's new constitution.

    Science.gov (United States)

    1996-09-20

    Fundamental principles designed to ensure that South Africa's new constitution upholds a wide range of individual rights and freedoms and establishes a responsive government with a balanced separation of powers, including recognition of the role of traditional tribal leadership, were adopted into the current interim constitution shortly before the 1994 free elections which brought Nelson Mandela and the African National Congress to power. In a judgement issued on September 6, 1996, South Africa's Constitutional Court rejected the country's new draft constitution, arguing that it failed to meet the standards of nine of the 34 principles established at the Kempton Park negotiations. The Constitutional Assembly is comprised of a joint meeting of the National Assembly and Senate. One of the court's major objections to the constitution concerned the proposed structure of rule, which was seen to give inadequate power to South Africa's nine provinces as compared with the national government. However, the bill of rights was almost entirely upheld. The bill would create a favorable environment for legalized abortion and guarantee a universal right of access to health care, including reproductive health services

  2. BIBLICAL MOTIFS IN THE UNDERSTANDING THE MANUSCRIPTS OF A SCRIBE FROM PECHORA I. S. MYANDIN

    Directory of Open Access Journals (Sweden)

    Tatyana Fedorovna Volkova

    2014-11-01

    Full Text Available The paper off ers a survey of manuscripts of a peasant, Old Believer and knizhnik I. S. Miandin (1823–1894, Ust’-Tsilma, Komi Republic from the Old Manuscript Division of the IRLI (Institute of Russian Literature of the Russian Academy of Science or Pushkinskiy Dom. Knizhnik, in the Russian tradition, is a scribe, who also can recite from memory the Scripture texts and the patristic tradition. Miandin left his recapitulations of the Old Believers literary tradition. He left few compilations, transcribed a number of Old Russian texts of various genres. In four convolutes, he collected Biblical stories taken from chronographs. Most of Miandin’s stories recapitulate the Old Testament texts, but there are also legends from the early Christian history (e. g., The Story of Emperor Constantine and His Mother Helen. His major source was, in all probability, the copy of the Chronograph from the Old Believers tradition which he had in his possession (he lent it to a writer S. V. Maksimov and never received it back. The whereabouts of the Chronographer are not known. Some of the stories were signifi cantly reworked by Miandin in comparison with the chronographic version. Among those the are the stories of Joseph the Beautiful, King Solomon and Judith. Th e study of Miandin’s manuscripts demosntrates that the fi rst stage of his work is refl ected in the IRLI reduction (Ust’-Tsil’ma collection #267, the second – idem, #66, the third – RNB NSRK О.100. The Biblical protagonists were interpreted according to the understanding of life by Pechora peasants. The peripeteias were taken with empathy as if they were concerned people next-door. This attitude compelled the narrator to seek, from one version to another, the most convincing motivations for the action of the heroes.

  3. Application of spectroscopic techniques to the study of illuminated manuscripts: A survey

    Energy Technology Data Exchange (ETDEWEB)

    Pessanha, S.; Manso, M.; Carvalho, M.L., E-mail: luisa@cii.fc.ul.pt

    2012-05-15

    This work focused on the application of the most relevant spectroscopic techniques used for the characterization of illuminated manuscripts. The historical value of these unique and invaluable artworks, together with the increased awareness concerning the conservation of cultural heritage, prompted the application of analytical techniques to the study of these illuminations. This is essential for the understanding of the artist's working methods, which aids conservation-restoration. The characterization of the pigments may also help assign a probable date to the manuscript. For these purposes, the spectroscopic techniques used so far include those that provide information on the elemental content: X-ray fluorescence, total reflection X-ray fluorescence and scanning electron microscopy coupled with energy-dispersive spectroscopy and laser-induced breakdown spectroscopy. Complementary techniques, such as X-ray diffraction, Fourier transform infrared and Raman spectroscopy, reveal information regarding the compounds present in the samples. The techniques, suitability, technological evolution and development of high-performance detectors, as well as the possibility of microanalysis and the higher sensitivity of the equipment, will also be discussed. Furthermore, issues such as the necessity of sampling, the portability of the equipment and the overall advantages and disadvantages of different techniques will be analyzed. - Highlights: Black-Right-Pointing-Pointer The techniques used for studying illuminated manuscripts are described and compared. Black-Right-Pointing-Pointer For in situ, non-destructive analysis the most suitable technique is EDXRF. Black-Right-Pointing-Pointer For quantitative analysis TXRF is more appropriate. Black-Right-Pointing-Pointer Raman spectroscopy is mostly used for pigments identification. Black-Right-Pointing-Pointer FTIR was used for the characterization of binders and parchment.

  4. Conversion of Plastic Surgery meeting abstract presentations to full manuscripts: a brazilian perspective.

    Science.gov (United States)

    Denadai, Rafael; Pinho, André Silveira; Samartine, Hugo; Denadai, Rodrigo; Raposo-Amaral, Cassio Eduardo

    2017-01-01

    to assess the conversion rate of Plastic Surgery meeting abstract presentations to full manuscript publications and examine factors associated with this conversion. we assessed the abstracts presented at the 47th and 48th Brazilian Congresses of Plastic Surgery by cross-referencing with multiple databases. We analyzed the Abstracts' characteristics associated with full manuscript publications. of the 200 abstracts presented, 50 abstracts were subsequently published in full, giving the conference a conversion rate of 25%. The mean time to publish was 15.00±13.75 months. In total, there were 4.93±1.63 authors per abstract and 67.8±163 subjects per abstract; 43.5% of the abstracts were of retrospective studies; 69% comprised the plastic surgery topics head and neck, and chest and trunk, and 88.5% had no statistical analysis. Overall, 80% of the manuscripts were published in plastic surgery journals, 76% had no impact factor and 52% had no citations. Bivariate and multivariate analyses revealed the presence of statistical analysis to be the most significant (previstas de Cirurgia Plástica, 76% não exibiam fator de impacto e 52% não possuíam citações. As análises bivariada e multivariada revelaram que a presença de análise estatística foi o fator preditivo significativo (p<0,05) para a conversão de resumos em manuscritos completos. a taxa de conversão deste estudo bibliométrico foi inferior à tendência de conversão descrita em congressos internacionais de Cirurgia Plástica, e a presença de análise estatística foi um determinante para o sucesso de conversão.

  5. Probing the statistical properties of unknown texts: application to the Voynich Manuscript.

    Directory of Open Access Journals (Sweden)

    Diego R Amancio

    Full Text Available While the use of statistical physics methods to analyze large corpora has been useful to unveil many patterns in texts, no comprehensive investigation has been performed on the interdependence between syntactic and semantic factors. In this study we propose a framework for determining whether a text (e.g., written in an unknown alphabet is compatible with a natural language and to which language it could belong. The approach is based on three types of statistical measurements, i.e. obtained from first-order statistics of word properties in a text, from the topology of complex networks representing texts, and from intermittency concepts where text is treated as a time series. Comparative experiments were performed with the New Testament in 15 different languages and with distinct books in English and Portuguese in order to quantify the dependency of the different measurements on the language and on the story being told in the book. The metrics found to be informative in distinguishing real texts from their shuffled versions include assortativity, degree and selectivity of words. As an illustration, we analyze an undeciphered medieval manuscript known as the Voynich Manuscript. We show that it is mostly compatible with natural languages and incompatible with random texts. We also obtain candidates for keywords of the Voynich Manuscript which could be helpful in the effort of deciphering it. Because we were able to identify statistical measurements that are more dependent on the syntax than on the semantics, the framework may also serve for text analysis in language-dependent applications.

  6. Early Portuguese lexicographic tradition: equivalents and loans in Caetano de Lima’s dictionary manuscripts

    Directory of Open Access Journals (Sweden)

    J. P. Silvestre

    2013-10-01

    Full Text Available The exhaustive comparison between Portuguese and the main modern languages is a late phenomenon. Only at the end of seventeenth century, did Portugal feel the need for a methodical learning of foreign languages and for didactic tools with a marked lexical component, in which we include the essential bilingual dictionaries. Nevertheless, it is in the first half of the eighteenth century that the first glossaries are published, while the first bilingual dictionaries with alphabetical order and an extensive nomenclature will appear only in the second half of the century. In order to overcome this lag, Vernacular-Latin dictionaries were imported and handwritten dictionaries were compiled and adapted according to the needs of each user. Research on the origins of Portuguese-Italian lexicography has provided important information on the development of the techniques used to compile dictionaries and the contrastive analysis of languages. The first printed dictionary is an addition to Caetano de Lima’s Grammatica Italiana (1734 and it contains an appendix of hard words (where semantic peculiarities and idiomatic expressions are explained and an onomasiologic dictionary of common words. It has been described as a basic albeit functional lexicographic tool, suitable for beginners’ needs. Recently, a manuscript version of this dictionary has been identified (Diccionario de Nomes Portuguezes e Italianos Dispostos por Materias, Biblioteca Pública de Évora, CXIII-1-33, as well as the manuscript of a larger general dictionary (Diccionario Italiano-Portuguez, Biblioteca Nacional de Portugal, cod. 3342. This impressive lexicographic corpus is compiled about fifty years before the first printed Italian-Portuguese dictionary. The analysis demonstrates that the author tried to compile a much wider dictionary than the version that was actually published. In the manuscript, we can identify problems in some areas, such as the definition of lexical domains (due

  7. Rejection of micropollutants by clean and fouled forward osmosis membrane.

    Science.gov (United States)

    Valladares Linares, Rodrigo; Yangali-Quintanilla, Victor; Li, Zhenyu; Amy, Gary

    2011-12-15

    As forward osmosis (FO) gains attention as an efficient technology to improve wastewater reclamation processes, it is fundamental to determine the influence of fouling in the rejection of emerging contaminants (micropollutants). This study focuses on the rejection of 13 selected micropollutants, spiked in a secondary wastewater effluent, by a FO membrane, using Red Sea water as draw solution (DS), differentiating the effects on the rejection caused by a clean and fouled membrane. The resulting effluent was then desalinated at low pressure with a reverse osmosis (RO) membrane, to produce a high quality permeate and determine the rejection with a coupled forward osmosis - low pressure reverse osmosis (FO-LPRO) system. When considering only FO with a clean membrane, the rejection of the hydrophilic neutral compounds was between 48.6% and 84.7%, for the hydrophobic neutrals the rejection ranged from 40.0% to 87.5%, and for the ionic compounds the rejections were between 92.9% and 96.5%. With a fouled membrane, the rejections were between 44.6% and 95.2%, 48.7%-91.5% and 96.9%-98.6%, respectively. These results suggest that, except for the hydrophilic neutral compounds, the rejection of the micropollutants is increased by the presence of a fouling layer, possibly due to the higher hydrophilicity of the FO fouled membrane compared to the clean one, the increased adsorption capacity of hydrophilic compounds and reduced mass transport capacity, membrane swelling, and the higher negative charge of the membrane surface, related to the foulants composition, mainly NOM acids (carboxylic radicals) and polysaccharides or polysaccharide-like substances. However, when coupled with RO, the rejections in both cases increased above 96%. The coupled FO-LPRO system was an effective double barrier against the selected micropollutants.

  8. Rejection of micropollutants by clean and fouled forward osmosis membrane

    KAUST Repository

    Valladares Linares, Rodrigo

    2011-12-01

    As forward osmosis (FO) gains attention as an efficient technology to improve wastewater reclamation processes, it is fundamental to determine the influence of fouling in the rejection of emerging contaminants (micropollutants). This study focuses on the rejection of 13 selected micropollutants, spiked in a secondary wastewater effluent, by a FO membrane, using Red Sea water as draw solution (DS), differentiating the effects on the rejection caused by a clean and fouled membrane. The resulting effluent was then desalinated at low pressure with a reverse osmosis (RO) membrane, to produce a high quality permeate and determine the rejection with a coupled forward osmosis - low pressure reverse osmosis (FO-LPRO) system. When considering only FO with a clean membrane, the rejection of the hydrophilic neutral compounds was between 48.6% and 84.7%, for the hydrophobic neutrals the rejection ranged from 40.0% to 87.5%, and for the ionic compounds the rejections were between 92.9% and 96.5%. With a fouled membrane, the rejections were between 44.6% and 95.2%, 48.7%-91.5% and 96.9%-98.6%, respectively. These results suggest that, except for the hydrophilic neutral compounds, the rejection of the micropollutants is increased by the presence of a fouling layer, possibly due to the higher hydrophilicity of the FO fouled membrane compared to the clean one, the increased adsorption capacity of hydrophilic compounds and reduced mass transport capacity, membrane swelling, and the higher negative charge of the membrane surface, related to the foulants composition, mainly NOM acids (carboxylic radicals) and polysaccharides or polysaccharide-like substances. However, when coupled with RO, the rejections in both cases increased above 96%. The coupled FO-LPRO system was an effective double barrier against the selected micropollutants. © 2011 Elsevier Ltd.

  9. Datasets used in the manuscript titled "Nitrate radicals and biogenic volatile organic compounds: oxidation, mechanisms and organic aerosol"

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset documents that all of the data used in the manuscript "Nitrate radicals and biogenic volatile organic compounds: oxidation, mechanisms, and organic...

  10. Rejected by Peers--Attracted to Antisocial Media Content: Rejection-Based Anger Impairs Moral Judgment among Adolescents

    Science.gov (United States)

    Plaisier, Xanthe S.; Konijn, Elly A.

    2013-01-01

    Adolescence is an important developmental stage during which both peers and the media have a strong influence. Both peer rejection and the use of morally adverse media are associated with negative developmental outcomes. This study examines processes by which peer rejection might drive adolescents to select antisocial media content by tying…

  11. Raman microscopy and x-ray fluorescence analysis of pigments on medieval and Renaissance Italian manuscript cuttings

    OpenAIRE

    Burgio, Lucia; Clark, Robin J.H.; Hark, Richard R.

    2010-01-01

    Italian medieval and Renaissance manuscript cuttings and miniatures from the Victoria and Albert Museum were analyzed by Raman microscopy to compile a database of pigments used in different periods and different Italian regions. The palette identified in most manuscripts and cuttings was found to include lead white, gypsum, azurite, lazurite, indigo, malachite, vermilion, red lead, lead tin yellow (I), goethite, carbon, and iron gall ink. A few of the miniatures, such as the historiated capit...

  12. Submission of scientifically sound and ethical manuscripts to peer-reviewed journals - a reviewer's personal perspective on bioanalytical publications.

    Science.gov (United States)

    Weng, Naidong

    2012-11-01

    In the pharmaceutical industry, bioanalysis is very dynamic and is probably one of the few fields of research covering the entire drug discovery, development and post-marketing process. Important decisions on drug safety can partially rely on bioanalytical data, which therefore can be subject to regulatory scrutiny. Bioanalytical scientists have historically contributed significant numbers of scientific manuscripts in many peer-reviewed analytical journals. All of these journals provide some high-level instructions, but they also leave sufficient flexibility for reviewers to perform independent critique and offer recommendations for each submitted manuscript. Reviewers play a pivotal role in the process of bioanalytical publication to ensure the publication of high-quality manuscripts in a timely fashion. Their efforts usually lead to improved manuscripts. However, it has to be a joint effort among authors, reviewers and editors to promote scientifically sound and ethically fair bioanalytical publications. Most of the submitted manuscripts were well written with only minor or moderate revisions required for further improvement. Nevertheless, there were small numbers of submitted manuscripts that did not meet the requirements for publications because of scientific or ethical deficiencies, which are discussed in this Letter to the Editor. Copyright © 2012 John Wiley & Sons, Ltd.

  13. [Tracing back for the basis. Research of Medieval medical manuscripts in Leipzig by Karl Sudhoff and Henry Ernest Sigerist].

    Science.gov (United States)

    Löffler, Anette

    2009-01-01

    At the beginning of the 20th century, two known medical historians, Karl Sudhoff and Henry Ernst Sigerist, were among the first persons, who took up thorough investigations of medical manuscripts in Leipzig. Above all, it was Mr. Sudhoff, who developed his own procedure, in order to exploit the unknown stocks. Apart from the only means available to him, the so-called Leyser-papers, written by the Leipzig librarian Hermann Leyser, at least once Sudhoff made a complete check-up of all manuscripts over the period of 22 years. On 315 sheets he took down various more or less extensive notes regarding these Codices, which are kept today as manuscript collection (Ms 01269) in the library of the university of Leipzig. Many publications were written on the basis of these readings. Sigerist was only looking through a small number of Leipzig manuscripts, as could be seen from his remarks written onto the users' cards. However, he could rely on Sudhoff's notes and look for specific manuscripts that he was interested in and review them. This was a first and very important step for the investigation of Leipzig medical manuscripts.

  14. 医学研究生应该重视论文写作中的统计学问题%Medical Master Should Pay Good Attention to Statistical Problems Existing in the Manuscripts

    Institute of Scientific and Technical Information of China (English)

    姜敏; 储怡星

    2011-01-01

    Misusing and abuse-using of statistical analyses are common problems existing in medical manuscripts. These problems are found in almost all aspects of statistical analyzing. In order to secure publications quality, editors would review all statistical analyses mentioned in "material and methods" ," results" and "conclusion" parts respectively to find those problems and give revision suggestions to authors. Manuscripts will be retrieved when false analyses are found out. To avoid manuscripts rejection caused by those problems, post- graduate should pay good attention to accurate choosing of statistical methods and reviewer's revision suggestions.%研究生在撰写医学论文时普遍存在统计学误用和滥用问题,几乎在统计学应用的各个环节上都有不妥甚至错误之处.为保证期刊质量,医学期刊编辑在处理稿件时,将会从论文中"材料和方法"、"结果"、"结论"几部分分别审查稿件中的统计学问题,一旦发现统计学错误,稿件就会被退回.因此,为避免因为统计学问题被拒稿,研究生应在论文撰写时正确运用统计学方法,对稿件退修中的统计学方法修改意见要引起足够的重视.

  15. Acute rejection episodes after kidney transplantation

    Directory of Open Access Journals (Sweden)

    Hamida Fethi

    2009-01-01

    Full Text Available Acute rejection episodes (AREs are a major determinant of renal allograft survival. The incorporation of new immunosuppressive agents explains, at least partially, the improvement seen in the results of transplantation in recent years. The objectives of this study are to analyze the incidence and severity of AREs, their risk factors and their influence on graft and patient survival. We retrospectively studied 280 kidney transplants performed in adults at the Charles Nicolle Hospital, Tunis, between 1986 and 2004. The diagnosis of ARE was based on clinical data and response to treatment. Allograft biopsies were performed in ten cases. The treatment of AREs consisted of pulse methylprednisolone and anti-thymocyte globulin. There were 186 males (66.4% and 94 females (33.6%, and their mean age was 31 ± 8.9 years. Overall, the 280 study patients experienced a total of 113 AREs. Of them, 85 had only one ARE, 28 had two to three and none had more than three AREs. A total of 68 AREs were completely re-versible, 42 were partially reversible while three could not be reversed with treatment. The mean inci-dence of AREs was 40.4%. The incidence was > 45% between 1986 and 1997, decreased to 20.5% between 1998 and 2000 and to 9% between 2001 and 2004. Graft survival rates in patients with and without AREs were respectively 91% and 93% at three years, 82% and 90% at five years and 73% and 83% at 10 years. We found a decrease in the incidence of AREs in recent years in our study patients, and this was related to the introduction of sensitized cross-match and the newer immunosuppressive agents, particularly MMF. Additionally, AREs had a deleterious impact on late graft survival in our study population.

  16. Manuscript "Collection of Solved Problems of General Astronomy" by Vojislav Miskovic

    Science.gov (United States)

    Pejovic, N.

    2009-09-01

    In this paper we present the first university problems book concerning astronomy written in Serbian. The topic is "Zbirka rešenih zadataka iz opšte astronomije" (A Collection of Solved Problems of General Astronomy) by Prof. Vojislav Mi\\vsković. The first part of this collection was published in 1956 in Belgrade. The second one is still in the form of a manuscript. Though completely prepared for publishing, it has never been published. From the methodical point of view the collection was interestingly and nicely arranged. All astronomical notions and formulae are treated in details and well explained so that no complementary textbook is needed. A special attention is devoted to the numerical solution of the problems, which is not only missing in Serbian schools, but also, as said by Mi\\vsković in the Preface, is not properly valued. This paper treats both parts of this Collection which have been digitized and are available in the Virtual Library of the National Digitization Centre (Virtual Library, http://elib.matf.bg.ac.yu:8080/virlib/). By means of the manuscript digitization the second part of the Collection has become available to public use.

  17. Trace element analysis of the Otani Collection's Dunhuang and Turfan manuscripts by PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Kohno, M.; Yoshida, K.; Moritani, K.; Norizawa, K. [Department of Nuclear Engineering, Kyoto Univ., Sakyo, Kyoto (Japan); Enami, K.; Kasajima, H. [Ryukoku Univ., Department of Mechanical and System Engineering, Otsu, Shiga (Japan); Ueyama, D. [Ryukoku Univ., Faculty of Intercultural Communication, Otsu, Shiga (Japan); Takada, J.; Matsushita, R. [Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst

    1999-07-01

    In order to classify the Otani Collection's Dunhuang and Turfan manuscripts, their trace elements were analyzed by PIXE. The paper samples of these manuscripts were fallen off when they were photographed for a CD-ROM catalog. These samples were very small and their size was less than several millimeters. In addition, some paper fragments dating from the late Edo-era of Japan and the late Qing Dynasty of China, and modern Japanese handmade paper were analyzed using PIXE and NAA. Quite interesting results were obtained when analyzing the trace elements - Na, Mg, Al, Si, S, Cl, K, Ca, Sc, Mn, Fe, Cu, Zn, As, Br, Sr, Ba, Pb, La, Sm. It was found that Dunhuang and Turfan papers of the Otani Collection were characterized by its highest iron and bromine content. The reason of the highest iron content probably originates in their making process and/or depends on their preservative environment. On the other hand, it became clear as for the highest bromine content that the origin is from fumigation of methyl bromide. (author)

  18. The role of food in the functional gastrointestinal disorders: introduction to a manuscript series.

    Science.gov (United States)

    Chey, William D

    2013-05-01

    Functional gastrointestinal disorders (FGIDs) are characterized by the presence of chronic or recurrent symptoms that are felt to originate from the gastrointestinal (GI) tract, which cannot be attributed to an identifiable structural or biochemical cause. Food is associated with symptom onset or exacerbation in a significant proportion of FGID patients. Despite this, the role of food in the pathogenesis of the FGIDs has remained poorly understood. For this reason, diet has largely played an adjunctive rather than a primary role in the management of FGID patients. In recent years, there has been a rapid expansion in our understanding of the role of food in GI function and sensation and how food relates to GI symptoms in FGID patients. In a series of evidence-based manuscripts produced by the Rome Foundation Working Group on the role of food in FGIDs, comprehensive reviews of the physiological changes associated with nutrient intake, and the respective roles of carbohydrates, fiber, protein, and fats are provided. The series concludes with a manuscript that provides guidance on proper clinical trial design when considering the role of food in FGIDs.

  19. SharedCanvas: A Collaborative Model for Medieval Manuscript Layout Dissemination

    Energy Technology Data Exchange (ETDEWEB)

    Sanderson, Robert D. [Los Alamos National Laboratory; Albritton, Benjamin [Stanford University; Schwemmer, Rafael [e-codices; Van De Sompel, Herbert [Los Alamos National Laboratory

    2011-01-01

    In this paper we present a model based on the principles of Linked Data that can be used to describe the interrelationships of images, texts and other resources to facilitate the interoperability of repositories of medieval manuscripts or other culturally important handwritten documents. The model is designed from a set of requirements derived from the real world use cases of some of the largest digitized medieval content holders, and instantiations of the model are intended as the input to collection-independent page turning and scholarly presentation interfaces. A canvas painting paradigm, such as in PDF and SVG, was selected based on the lack of a one to one correlation between image and page, and to fulfill complex requirements such as when the full text of a page is known, but only fragments of the physical object remain. The model is implemented using technologies such as OAI-ORE Aggregations and OAC Annotations, as the fundamental building blocks of emerging Linked Digital Libraries. The model and implementation are evaluated through prototypes of both content providing and consuming applications. Although the system was designed from requirements drawn from the medieval manuscript domain, it is applicable to any layout-oriented presentation of images of text.

  20. Separate neural representations for physical pain and social rejection.

    Science.gov (United States)

    Woo, Choong-Wan; Koban, Leonie; Kross, Ethan; Lindquist, Martin A; Banich, Marie T; Ruzic, Luka; Andrews-Hanna, Jessica R; Wager, Tor D

    2014-11-17

    Current theories suggest that physical pain and social rejection share common neural mechanisms, largely by virtue of overlapping functional magnetic resonance imaging (fMRI) activity. Here we challenge this notion by identifying distinct multivariate fMRI patterns unique to pain and rejection. Sixty participants experience painful heat and warmth and view photos of ex-partners and friends on separate trials. FMRI pattern classifiers discriminate pain and rejection from their respective control conditions in out-of-sample individuals with 92% and 80% accuracy. The rejection classifier performs at chance on pain, and vice versa. Pain- and rejection-related representations are uncorrelated within regions thought to encode pain affect (for example, dorsal anterior cingulate) and show distinct functional connectivity with other regions in a separate resting-state data set (N = 91). These findings demonstrate that separate representations underlie pain and rejection despite common fMRI activity at the gross anatomical level. Rather than co-opting pain circuitry, rejection involves distinct affective representations in humans.

  1. Rejection of Organic Micropollutants by Clean and Fouled Nanofiltration Membranes

    Directory of Open Access Journals (Sweden)

    Lifang Zhu

    2015-01-01

    Full Text Available The rejection of organic micropollutants, including three polycyclic aromatic hydrocarbons (PAHs and three phthalic acid esters (PAEs, by clean and fouled nanofiltration membranes was investigated in the present study. The rejection of organic micropollutants by clean NF90 membranes varied from 87.9 to more than 99.9%, while that of NF270 membranes ranged from 32.1 to 92.3%. Clear time-dependence was observed for the rejection of hydrophobic micropollutants, which was attributed to the adsorption of micropollutants on the membrane. Fouling with humic acid had a negligible influence on the rejection of organic micropollutants by NF90 membranes, while considerable effects were observed with NF270 membranes, which are significantly looser than NF90 membranes. The observed enhancement in the rejection of organic micropollutants by fouled NF270 membranes was attributed to pore blocking, which was a dominating fouling mechanism for loose NF membranes. Changes in the ionic strength (from 10 to 20 mM reduced micropollutant rejection by both fouled NF membranes, especially for the rejection of dimethyl phthalate and diethyl phthalate by NF270 membranes (from 65.8 to 25.0% for dimethyl phthalate and 75.6 to 33.3% for diethyl phthalate.

  2. Cardiac function and rejection following transplantation of the heart

    Energy Technology Data Exchange (ETDEWEB)

    Schober, O.; Schuler, S.; Gratz, K.; Warnecke, H.; Lang, W.; Hetzer, R.; Creutzig, H.

    1985-05-01

    It was the purpose of the study to evaluate the noninvasive detection of rejection following cardiac transplantation. Multigated cardiac blood pool imaging (MUGA) at rest with assessment of ejection fraction (EF) and regional wall motion was determined prospectively in 14 patients with 180 studies (follow up 5.1 +- 3.2 months) following orthotopic cardiac transplantation. The results were compared with histological examination of a percutaneous endocardial biopsy specimen (EMB) from the right ventricle. Diagnosis of rejection by EF measurement was defined by a decrease of 10% if EF < 70%, and 15% if EF > 70%. In 152 studies a normal MUGA study correlated with none rejection as defined by EMB. In 14 of 22 studies with moderate or severe rejection decrease of EF followed the rejection with a delay of 5 days. Septal wall motion abnormalities were typical. In 6 studies an abnormal temporal course of EF was not related to a similar finding in EMB. A sensitivity of 69% and a specifity of 96% can be estimated in the investigated group, in which all patients survived during the period of the study. It is concluded that rejection can be excluded by noninvasive MUGA (specifity 96%) and that MUGA is predictive of rejection (sensitivity 67%) mostly with a delay of 5 days.

  3. SCHEDULING WITH REJECTION AND NON-IDENTICAL JOB ARRIVALS

    Institute of Scientific and Technical Information of China (English)

    Zhigang CAO; Yuzhong ZHANG

    2007-01-01

    In this paper, we address the scheduling problem with rejection and non-identical job arrivals, in which we may choose not to process certain jobs and each rejected job incurs a penalty.Our goal is to minimize the sum of the total penalties of the rejected jobs and the maximum completion time of the processed ones. For the off-line variant, we prove its NP-hardness and present a PTAS, and for the on-line special case with two job arrivals, we design a best possible algorithm with competitive ratio (√5+1)/2.

  4. Suicide Screening for Prisoners: An Ethical Critique of Research Rejection.

    Science.gov (United States)

    Guinn, David; Burgermeister, Diane M

    2016-01-01

    A retrospective review of medical records was proposed to examine mental health staff compliance with documentation of a suicide assessment tool according to institutional policy on suicide screening within a U.S. correctional facility. A shift in focus was necessary when the proposed study was rejected by the institutional review board. Reasons for the rejection included low perceived benefit versus greater risk to the correctional facility and the need for prisoner informed consent, albeit the design was a retrospective medical record review. Because of this rejection, ethical issues in the prevention of suicide in prisons were examined with implications for the forensic nurse leading quality improvement initiatives.

  5. Stem Cells Transplanted in Monkeys without Anti-Rejection Drugs

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160989.html Stem Cells Transplanted in Monkeys Without Anti-Rejection Drugs Scientists say goal is to create banks of stem cells that could be used for any human patient ...

  6. Social rejection shares somatosensory representations with physical pain

    National Research Council Canada - National Science Library

    Ethan Kross; Marc G. Berman; Walter Mischel; Edward E. Smith; Tor D. Wager

    2011-01-01

    How similar are the experiences of social rejection and physical pain? Extant research suggests that a network of brain regions that support the affective but not the sensory components of physical pain underlie both experiences...

  7. Children's Use of Memory Editing Strategies to Reject Source Misinformation.

    Science.gov (United States)

    Moore, Kara N; Lampinen, James M; Gallo, David A; Adams, Eryn J; Bridges, Ana J

    2017-02-15

    This is the first reported study of children's use of two metacognitive strategies, recollection rejection and diagnostic monitoring, to reject misinformation. Recollection rejection involves the retrieval of details that disqualify an event, whereas diagnostic monitoring involves the failure to retrieve expected details. First (n = 56, age 7 years) and third graders (n = 52, age 9 years) witnessed a staged classroom interaction involving common and bizarre accidents, were presented with misinformation about the source of these events, and took a memory test. Both age groups used recollection rejection, but third graders were more effective. There was little evidence that diagnostic monitoring influenced responses for bizarre events, potentially because these events were not sufficiently bizarre in the context of the stereotype induction.

  8. Marginality and Social Rejection in Amiri Baraka's Slave Ship

    Directory of Open Access Journals (Sweden)

    Hamid Hammad Abed

    2016-11-01

    Full Text Available Marginality and social rejection are the most influential matters exploited by Baraka to intentionally criticize the American society.  More often than not, these two matters have become the scenes of major or minor acts of humiliation and dehumanization that threaten to violate the ethical rules of living. This paper aims at investigating the impact of marginality and social rejection on a number of black characters in Baraka's Slave Ship who are brought to America to be sold as commodities. It is divided into two sections and conclusion. Section one deals with Amiri Baraka’s dramatic thought and experience of marginality within the American society. The textual analysis of Slave Ship is investigated in section two. The significance of the study lies in its textual exploration of the impact of marginality and social rejection in subverting the American dream of democracy, freedom, and equality in Baraka’s Slave Ship. Keywords: marginality, Baraka, rejection, slave ship, black

  9. Too many journals? Towards a theory of repeated rejections and ultimate acceptance

    NARCIS (Netherlands)

    Oosterhaven, Jan

    Under a set of reasonable assumptions, it is shown that all manuscripts submitted to any journal will ultimately be published, either by the first journal or by one of the following journals to which a manuscript is resubmitted. This suggests that low quality manuscripts may also be published, which

  10. ON-LINE SCHEDULING WITH REJECTION ON IDENTICAL PARALLEL MACHINES

    Institute of Scientific and Technical Information of China (English)

    Cuixia MIAO; Yuzhong ZHANG

    2006-01-01

    In this paper, we consider the on-line scheduling of unit time jobs with rejection on m identical parallel machines. The objective is to minimize the total completion time of the accepted jobs plus the total penalty of the rejected jobs. We give an on-line algorithm for the problem with competitive ratio 1/2(2 + √3) ≈ 1.86602.

  11. Inflammatory mediators and cytotoxins in cardiac allograft rejection

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, R.P.; Powell, W.S.; Blais, D.; Marghesco, D.

    1986-03-01

    Though organ allograft rejection in rats has been linked to delayed type hypersensitivity (DTH) the pathogenesis of DTH induced tissue injury is uncertain. Accordingly, the authors have undertaken to identify the following inflammatory mediators/cytotoxins in rejecting rat cardiac allografts (WF ..-->.. LEW, day 5): phospholipase A/sub 2/(PLA/sub 2/ in cardiac homogenates assessed using /sup 14/C oleate labelled E Coli), PAF in lipid extracts of grafts measured by aggregation of rabbit platelets, arachidonic acid (AA) metabolites (HPLC analysis of products released from isolated perfused hearts and slices prelabelled with /sup 3/H-AA), lymphotoxin and/or tumor necrosis factor (LT/TNF release in vitro from infiltrating mononuclear cells assayed using cell line varies as L929. Briefly, aliquots of homogenates (10ml) of rejecting grafts demonstrated PLA/sub 2/ activity as evidenced by liberation of FFA from bacterial phospholipids (baseline 3%, 1 ..mu..1 4%, 25 ..mu..l 24%, 100 /sup +/l 29%, 200 ..mu..l 39%; control hearts, 200 ..mu..l 5%). Rejecting cardiac allografts contained approximately 10 ng PAF while PAF recovered from syngeneic grafts was less than or equal to 5 ng. Observed changes in eicosanoid biosynthesis with rejection were limited to a decrement in 6 oxo PGF/sub /sub 1/..cap alpha../ release. Infiltrating mononuclear cells recovered from rejecting grafts released greater than or equal to 64 units of cytotoxin (LT and/or TNF). The author present results, documenting a decrement in prostacyclin release by rejecting heart grafts, the presence of PLA/sub 2/ and PAF and the release of cytotoxins (LT and/or TNF) by infiltrating mononuclear cells are compatible with the thesis that allograft rejection must be viewed as a complex immune/inflammatory process. Additional studies are clearly required to define roles of these and other soluble factors in homograft destruction.

  12. Maternal Predictors of Rejecting Parenting and Early Adolescent Antisocial Behavior

    OpenAIRE

    Trentacosta, Christopher J.; Daniel S Shaw

    2007-01-01

    The present study examined relations among maternal psychological resources, rejecting parenting, and early adolescent antisocial behavior in a sample of 231 low-income mothers and their sons with longitudinal assessments from age 18 months to 12 years. The maternal resources examined were age at first birth, aggressive personality, and empathy. Each of the maternal resources predicted rejecting parenting during early childhood in structural equation models that controlled for toddler difficu...

  13. Good practices for a literature survey are not followed by authors while preparing scientific manuscripts

    CERN Document Server

    Amancio, D R; Oliveira, O N; Costa, L da F

    2010-01-01

    The number of citations received by authors in scientific journals has become a major parameter to assess individual researchers and the journals themselves through the impact factor. A fair assessment therefore requires that the criteria for selecting references in a given manuscript should be unbiased with respect to the authors or the journals cited. In this paper, we advocate that authors should follow two mandatory principles to select papers (later reflected in the list of references) while studying the literature for a given research: i) consider similarity of content with the topics investigated, lest very related work should be reproduced or ignored; ii) perform a systematic search over the network of citations including seminal or very related papers. We use formalisms of complex networks for two datasets of papers from the arXiv repository to show that neither of these two criteria is fulfilled in practice.

  14. Application of image processing technology to problems in manuscript encapsulation. [Codex Hammer

    Science.gov (United States)

    Glackin, D. L.; Korsmo, E. P.

    1983-01-01

    The long term effects of encapsulation individual sheets of the Codex Hammer were investigated. The manuscript was simulated with similar sheets of paper which were photographed under repeatable raking light conditions to enhance their surface texture, encapsulated in plexiglas, cycled in an environmental test chamber, and rephotographed at selected intervals. The film images were digitized, contrast enhanced, geometrically registered, and apodized. An FFT analysis of a control sheet and two experimental sheets indicates no micro-burnishing, but reveals that the ""mesoscale'' deformations with sizes 8mm are degrading monotonically, which is of no concern. Difference image analysis indicates that the sheets were increasingly stressed with time and that the plexiglas did not provide a sufficient environmental barrier under the simulation conditions. The relationship of these results to the Codex itself is to be determined.

  15. Military Equipment in the Byzantine Manuscript of Scylitzes in Biblioteca Nacional de Madrid

    Directory of Open Access Journals (Sweden)

    Bruhn Hoffmeyer, Ada

    1966-12-01

    Full Text Available The purpose of the present paper is to provide an introduction to the military equipment of the Second Golden Age of the Byzantine empire as represented not by the text of Scylitzes but by the illuminators of this marvellous manuscript, the relations of the illuminations to the actual weapons and their chronology.

    El propósito de este trabajo es proporcionar una introducción al equipamiento militar durante la Segunda Edad de Oro del Imperio Bizantino, tal y como se representa no a través del texto, sino de las iluminaciones, del manuscrito Scylitzes de la Biblioteca Nacional de Madrid, y la comparación de las iluminaciones con el armamento auténtico y su cronología. [traducción para esta edición electrónica

  16. Guidelines for Manuscripts Submitted to The China Journal of Accounting Research

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>The China Journal of Accounting Research"CJAR"(ISSN 1755-3091)publishes quarterly.It contains peer-reviewed articles and commentaries on accounting,auditing and corporate governance issues that relate to the greater China region.We welcome the submission of both theoretical and empirical research papers pertinent to researchers,regulators and practitioners.Authors should note:1 Submissions must be original contributions and not under consideration by any other journal.The author must state the work is not submitted or published elsewhere.2 Authors submitting articles,notes and comments will be entitled to two free copies.Each author of a book review will receive a copy of the relevant issue.3 Authors should submit their manuscripts(in Word format)via email to china.jar@gmail.com.All text,including endnotes,

  17. ["For a history of vaccination in Brazil": an unpublished manuscript by Norberto and Macedo].

    Science.gov (United States)

    Lopes, Myriam Bahia; Polito, Ronald

    2007-01-01

    The manuscript "Para uma história da vacina no Brasil" [For a history of vaccination in Brazil] was unearthed in the archives of Instituto Histórico Geográfico Brasileiro (IHGB) along with other texts by Joaquim Manoel de Macedo. It was written in partnership with Joaquim Norberto in 1859 in response to a request by the Emperor to the institute. Its characteristics mark it out as a founding text: its arguments are designed to establish who really introduced the smallpox vaccine to Brazil and to resolve the controversy between the Marquis of Barbacena and a surgeon, Francisco Mendes Ribeiro de Vasconcellos. It analyzes the documents that provide the basis for both versions and consolidates the beginning of the history of vaccination in Brazilian territory in 1878, which was subsequently recognized by IHGB.

  18. The Slavic books in the 16th century: between manuscripts and printings

    Directory of Open Access Journals (Sweden)

    Neža Zajc

    2013-09-01

    Full Text Available ABSTRACTPurpose: The article explores the Slavic typography in the Renaissance with special emphasis on the Cyrillic incunabula and on the complex process of building national languages in the Slavic regions, which are also related to the position of Christian theology (Orthodox, Catholic, and Protestant of that time.Methodology/approach: The analysis of primary resources i.e. manuscripts and incunabula was used for the presentation of the complexity position of the Slavic languages in the 16th century.Results: It was difficult to separate the orthodox texts from the apocryphal contents of Christian texts.Research limitation: This study presents the general review and analysis of specific cases and as such it represents a basic introduction in to a more sophisticated research.Originality/practical implications: The study shows that the language disunity (the instability of the linguistic forms could be one the reasons for difficulties in printing the Slavic texts in 16th century.

  19. A novel noninvasive method to detect rejection after heart transplantation

    Directory of Open Access Journals (Sweden)

    Jun Hu

    2012-12-01

    Full Text Available Prompt and accurate detection of rejection prior to pathological changes after organ transplantation is vital for monitoring rejections. Although biopsy remains the current gold standard for rejection diagnosis, it is an invasive method and cannot be repeated daily. Thus, noninvasive monitoring methods are needed. In this study, by introducing an IL-2 neutralizing monoclonal antibody (IL-2 N-mAb and immunosuppressants into the culture with the presence of specific stimulators and activated lymphocytes, an activated lymphocyte-specific assay (ALSA system was established to detect the specific activated lymphocytes. This assay demonstrated that the suppression in the ALSA test was closely related to the existence of specific activated lymphocytes. The ALSA test was applied to 47 heart graft recipients and the proliferation of activated lymphocytes from all rejection recipients proven by endomyocardial biopsies was found to be inhibited by spleen cells from the corresponding donors, suggesting that this suppression could reflect the existence of activated lymphocytes against donor antigens, and thus the rejection of a heart graft. The sensitivity of the ALSA test in these 47 heart graft recipients was 100%; however, the specificity was only 37.5%. It was also demonstrated that IL-2 N-mAb was indispensible, and the proper culture time courses and concentrations of stimulators were essential for the ALSA test. This preliminary study with 47 grafts revealed that the ALSA test was a promising noninvasive tool, which could be used in vitro to assist with the diagnosis of rejection post-heart transplantation.

  20. The private rejection of unfair offers and emotional commitment.

    Science.gov (United States)

    Yamagishi, Toshio; Horita, Yutaka; Takagishi, Haruto; Shinada, Mizuho; Tanida, Shigehito; Cook, Karen S

    2009-07-14

    In a series of experiments, we demonstrate that certain players of an economic game reject unfair offers even when this behavior increases rather than decreases inequity. A substantial proportion (30-40%, compared with 60-70% in the standard ultimatum game) of those who responded rejected unfair offers even when rejection reduced only their own earnings to 0, while not affecting the earnings of the person who proposed the unfair split (in an impunity game). Furthermore, even when the responders were not able to communicate their anger to the proposers by rejecting unfair offers in a private impunity game, a similar rate of rejection was observed. The rejection of unfair offers that increases inequity cannot be explained by the social preference for inequity aversion or reciprocity; however, it does provide support for the model of emotion as a commitment device. In this view, emotions such as anger or moral disgust lead people to disregard the immediate consequences of their behavior, committing them to behave consistently to preserve integrity and maintain a reputation over time as someone who is reliably committed to this behavior.

  1. Higher boron rejection with a new TFC forward osmosis membrane

    KAUST Repository

    Valladares Linares, Rodrigo

    2014-07-17

    Due to the stringent limits for boron in drinking and irrigation water, water treatment facilities have to incur additional treatment to remove boron down to a safe concentration. Forward osmosis (FO) is a membrane technology that may reduce the energy required to remove boron present in seawater. In direct FO desalination hybrid systems, fresh water is recovered from seawater using a recoverable draw solution, FO membranes are expected to show high boron rejection. This study focuses on determining the boron rejection capabilities of a new generation thin-film composite (TFC) FO membrane compared to a first generation cellulose triacetate (CTA) FO membrane. The effects of water permeate flux, membrane structure, draw solute charge, and reverse solute flux on boron rejection were determined. For TFC and CTA FO membranes, experiments showed that when similar operating conditions are applied (e.g. membrane type and draw solute type) boron rejection decreases with increase in permeate flux. Reverse draw solute flux and membrane fouling have no significant impact on boron rejection. Compared to the first generation CTA FO membrane operated at the same conditions, the TFC FO membrane showed a 40% higher boron rejection capability and a 20% higher water flux. This demonstrates the potential for boron removal for new generation TFC FO membranes. © 2014 © 2014 Balaban Desalination Publications. All rights reserved.

  2. The Serbian translation of the "Evergetis synaxarion" in two Sinaitic manuscripts

    Directory of Open Access Journals (Sweden)

    Savić Viktor

    2016-01-01

    Full Text Available When the Greek substrate of the Hilandar (and Studenica typikon was discovered, scholars raised the issue whether the complete Greek text of the Evergetis Typikon had been translated into the Serbian language or not (1895. There were several attempts to prove that a complete version of the Evergetis Typikon had been used in the territory under the jurisdiction of the Serbian Church before the introduction of the Jerusalem Typikon (1318/1319. In the Description of the (Old Manuscript Collection of the Sinai Monasteries, Đorđe Sp. Radojičić suggested that there must have been a Serbian Small Euchologion (trebnik, hagiasmatarion with a synaxarion modelled in accordance with the typikon of the monastery of the Virgin Evergetis. Over the past several decades, attention has also been drawn to the presence of liturgical rules typical of the Evergetis Typikon in Serbian liturgical books (menaia and oktoechoi from the late 13th and early 14th century, but no definitive answer has been given to the question whether the whole liturgical section of the Evergetis Typikon was translated at the time of Saint Sava (at the turn of the 12th and 13th centuries or it happened later. The character of the Evergetis synaxaria, which were on various occasions identified in two Sinaitic manuscripts though no mutual relationship between them was established, also remains unknown. This paper seeks to offer a partial answer to these questions, with the idea of encouraging new research that will provide as detailed picture as possible of liturgy in the Serbian Church in the 13th and 14th centuries. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 178030: Obrada starog srpskog pisanog nasleđa i izrada Rečnika crkvenoslovenskog jezika srpske redakcije

  3. The 100 most cited manuscripts in emergency abdominal surgery: A bibliometric analysis.

    Science.gov (United States)

    Ellul, Thomas; Bullock, Nicholas; Abdelrahman, Tarig; Powell, Arfon G M T; Witherspoon, Jolene; Lewis, Wyn G

    2017-01-01

    The number of citations a scientific article receives provides a good indication of its impact within any given field. This bibliometric analysis aimed to identify the 100 most cited articles in Emergency Abdominal Surgery (EAS), to highlight key areas of interest and identify those that have most significantly shaped contemporary clinical practice in this newly evolving surgical specialty. This is of increasing relevance as concerns grow regarding the variable and suboptimal outcomes in Emergency General Surgery. The Thomson Reuters Web of Science database was used to search using the terms [Emergency AND Abdom* AND Surg*] to identify all English language, full manuscripts. Results were ranked according to citation number. The top 100 articles were further analysed by subject, author, journal, year of publication, institution, and country of origin. The median (range) citation number of the top 100 out of 7433 eligible papers was 131 (1569-97). The most cited paper (by Goldman et al., Massachusetts General Hospital, New England Journal of Medicine; 1569 citations) focused on cardiac risk stratification in non-cardiac surgery. The Journal of Trauma, Injury, Infection and Critical Care published the most papers and received most citations (n = 19; 2954 citations. The majority of papers were published by centres in the USA (n = 52; 9422 citations), followed by the UK (n = 13; 1816 citations). The most common topics of publication concerned abdominal aneurysm management (n = 26) and emergency gastrointestinal surgery (n = 26). Vascular surgery, risk assessment and gastrointestinal surgery were the areas of focus for 59% of the contemporary most cited emergency abdominal surgery manuscripts. By providing the most influential references this work serves as a guide to what makes a citable emergency surgery paper. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  4. The TaboAvatasakasūtra Corpus:Remarks on the Comparative Study of Manuscripts and Wall Inscriptions

    Institute of Scientific and Technical Information of China (English)

    Laxman S. Thakur

    2013-01-01

    AbstrActThe importance of the survival of the manuscript folios of the sūtras and tantras in the collection of the Tabo monastery in Himachal Pradesh is well known to the Buddhist scholarly world. Eleven manuscripts of theAvataṃsakasūtra have been identified among the Tabo corpus.1In total, about 90 folios of the four different manuscripts correspond to theGaṇḍavyūhasūtra that belongs to the last section of theAvataṃsakasūtra-corpus. What is interesting to note is that some portions of theGaṇḍavyūhasūtra wall inscriptions are available in the text of the manuscripts that are labelled as T 143 and T 268. The present paper makes an attempt to compare and translate the portions of the text available in manuscript number T 143 and T 268 and wall inscriptions and offers its textual comparison with the Sanskrit texts of theGaṇḍavyūhasūtra.2

  5. Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection

    Institute of Scientific and Technical Information of China (English)

    陈勇; 窦科峰; 何勇; 孙凯

    2003-01-01

    Objective: To study the cause and mechanism of transplantation vasculopathy which characterized by accelerated graft arteriosclerosis (AGA), we established a mouse aorta graft model. Methods: A segment of thoracic aortas of B10.A (2R) mice were transplanted to C57BL/10 mice abdominal aorta by end to side anastomoses. The different time point collected grafts were analyzed by morphological, histochemical and electro microscopic methods. Results: Rejection was manifested as a concentric progressive destruction of the smooth muscle cells. In contrast, the endothelial inflammation and subsequent neointimal proliferation characteristic of AGA was localized to the regions of turbulent flow, i.e. the junction of the graft with the recipient aorta. Conclusion: This model separates the processes of rejection and neointimal formation which usually manifested together in the lesion of AGA, elucidate that different mechanisms control vascular rejection and neointimal formation in chronic rejection.

  6. 111-Indium-labelled platelets for diagnosis of acute kidney transplant rejection and monitoring of prostacyclin anti-rejection treatment

    Energy Technology Data Exchange (ETDEWEB)

    Leithner, C.; Pohanka, E.; Schwarz, M. (Vienna Univ. (Austria). 2. Medizinische Klinik); Sinzinger, H. (Vienna Univ. (Austria). Abt. fuer Nuklearmedizin); Syre, G. (Vienna Univ. (Austria). Pathologisch-Anatomisches Inst.)

    1984-01-01

    33 patients were examined daily under a gamma camera after weekly injections of 111-In-labelled autologous platelets over a period of at least 4 weeks after transplantation. A group of 33 patients with long-term stable and well-functioning grafts served as controls. By means of a computerized recording technique, platelet trapping in the graft was measured and expressed as platelet-uptake index (PUI). The method worked well for the early diagnosis of acute rejection signified by an increase in PUI, accompanied by a shortening of platelet half life (t/2). 6 patients suffering from acute rejection received infusions of prostacyclin in addition to conventional high-dose methylprednisolone therapy. In 4 cases the PUI decreased again and an improvement in graft function was observed. Prostacyclin infusion treatment was applied also in 12 patients with histologically-proven chronic transplant rejection. Decreased platelet consumption by the graft and a temporary improvement in transplant function were achieved. We suggest that prostacyclin could enrich the possibilities of anti-rejection treatment by providing a tool for the suppression of platelet trapping in the graft. The platelet scan served as a useful method for the early detection of acute rejection, as well as the monitoring of prostacyclin anti-rejection treatment.

  7. Raman microscopy and x-ray fluorescence analysis of pigments on medieval and Renaissance Italian manuscript cuttings.

    Science.gov (United States)

    Burgio, Lucia; Clark, Robin J H; Hark, Richard R

    2010-03-30

    Italian medieval and Renaissance manuscript cuttings and miniatures from the Victoria and Albert Museum were analyzed by Raman microscopy to compile a database of pigments used in different periods and different Italian regions. The palette identified in most manuscripts and cuttings was found to include lead white, gypsum, azurite, lazurite, indigo, malachite, vermilion, red lead, lead tin yellow (I), goethite, carbon, and iron gall ink. A few of the miniatures, such as the historiated capital "M" painted by Gerolamo da Cremona and the Petrarca manuscript by Bartolomeo Sanvito, are of exceptional quality and were analyzed extensively; some contained unusual materials. The widespread usage of iron oxides such as goethite and hematite as minor components of mixtures with azurite is particularly notable. The use of a needle-shaped form of iron gall ink as a pigment rather than a writing material was established by both Raman microscopy and x-ray fluorescence spectroscopy for the Madonna and Child by Franco de' Russi.

  8. For the study of the manuscript biblical tradition: a new proposal for the analysis of codex 2437

    Directory of Open Access Journals (Sweden)

    Anderson de Oliveira Lima

    2016-06-01

    Full Text Available This article submitted to Horizonte Journal proposes a new way to study the codex 2437, a manuscript written in Greek between the centuries XII and XIII that brings the four Gospels of the canonical New Testament. The interest in this document is growing and it can be justified because it is part of the collection of the National Library of Rio de Janeiro, being considered the oldest manuscript in Latin America. The manuscript is, therefore, a cultural and material heritage that we need to preserve and study more. Our suggestion for the research aims to complement the traditional studies of textual criticism with a methodological framework that was extracted from the History of Writing Culture and contemporary literary studies, fields of knowledge that encourage us to take books not to deal only with its contents, but also to consider some aspects of materiality, paratexts and the history of their uses and readings.

  9. Completeness of reporting of radiation therapy planning, dose, and delivery in veterinary radiation oncology manuscripts from 2005 to 2010.

    Science.gov (United States)

    Keyerleber, Michele A; McEntee, Margaret C; Farrelly, John; Podgorsak, Matthew

    2012-01-01

    Surrounding a shift toward evidence-based medicine and widespread adoption of reporting guidelines such as the Consolidated Standards of Reporting Trials (CONSORT) statement, there has been a growing body of literature evaluating the quality of reporting in human and veterinary medicine. These reviews have consistently demonstrated the presence of substantive deficiencies in completeness of reporting. The purpose of this study was to assess the current status of reporting in veterinary radiation oncology manuscripts in regards to treatment planning methods, dose, and delivery and to introduce a set of reporting guidelines to serve as a standard for future reporting. Forty-six veterinary radiation oncology manuscripts published between 2005 and 2010 were evaluated for reporting of 50 items pertaining to patient data, treatment planning, radiation dose, delivery of therapy, quality assurance, and adjunctive therapy. A mean of 40% of checklist items were reported in a given manuscript (range = 8-75%). Only 9/50 (18%) checklist items were reported in > or = 80% manuscripts. The completeness of reporting was best in regards to a statement of prescription radiation protocol (91-98% reported) and worst in regards to specification of absorbed dose within target volumes and surrounding normal tissues (0-6% reported). No manuscripts met the current International Commission of Radiation Units and Measurements (ICRU) dose specification recommendations. Incomplete reporting may stem from the predominance of retrospective manuscripts and the variability of protocols and equipment in veterinary radiation oncology. Adoption of reporting guidelines as outlined in this study is recommended to improve the quality of reporting in veterinary radiation oncology.

  10. INTRATHYMIC INOCULATION OF LIVER SPECIFIC ANTIGEN ALLEVIATES LIVER TRANSPLANT REJECTION

    Institute of Scientific and Technical Information of China (English)

    贾长库; 郑树森; 朱有法

    2004-01-01

    Objective To study the effects of liver specific antigen (LSA) on liver allotransplantation rejection. Methods Orthotopic liver transplantation was performed in this study. Group Ⅰ: syngeneic control (Wistar-to-Wistar); Group Ⅱ: acute rejection (SD-to-Wistar). Group Ⅲ: thymic inoculation of SD rat LSA day 7 before transplantation. The observation of general condition and survival time, rejection grades and the NF-κB activity of splenocytes were used to analyze severity of acute rejection and immune state of animals in different groups. Results The general condition of group Ⅰ was fair post transplantation with no sign of rejection. All recipients of group Ⅱ died within days 9 to 13 post transplantation with median survival time of 10.7 ±1.37 days. As for group Ⅲ, 5 out of 6 recipients survived for a long period with remarkably better general condition than that of group Ⅱ. Its rejection grades were significantly lower than group Ⅱ (P< 0.05).NF-κB activity was only detected in group Ⅰ between days 5 and 7 after transplantation, whereas high activity of NF-κB was detected at all points in group Ⅱ and low NF-κB activity was detected in group Ⅲ which was significantly lower than that of group Ⅱ (P < 0.05). Conclusions LSA is an important transplantation antigen directly involved in the immunorejection of liver transplantation. Intrathymic inoculation of LSA can alleviate the rejection of liver allotransplantation,grafts survive for a period of time thereby, allowing a novel way to liver transplantation immunotolerance.

  11. Kutadgu Bilig'in Kahire Nüshası I Notes on Cairo Manuscript of Qutadgu Bilig I

    Directory of Open Access Journals (Sweden)

    Erdem UÇAR

    2012-09-01

    Full Text Available A lot of research has been done and monographies have been written regarding Qutadgu Bilig, however, only few of these were about its text and manuscripts. Because Reşit Rahmeti Arat (1900-1964 spent half of his life on this work and published a perfect translation and due to his scholarly authority, Turcologists handled the textualproblems of QB tentatively. It was Robert Dankoff who studied ReşitRahmeti Arat‟s publication and did remarkable and direct comments onit. Dankoff thinks that Arat‟s biggest mistake was to esteem threemanuscripts equally and acting with arbitrary attitude without aprinciple while introducing the main text. Dankoff took Arat‟sevaluations into cosideration and prepared the organization schemas ofthe manuscripts and suggested that the manuscripts went through asix step process. According to this schema, the lost X manuscript, thesource of Cairo and Vienna manuscripts, is based upon the Archtype,which was formed in the third phase. Cairo and Vienna manuscripts donot directly come from the same root. Vienna manuscript does not comefrom the root which Cairo manuscript is based upon (X manuscript. Itis based upon a Y manuscript, which is missing and comes from thesource that Cairo manuscript is based upon. Considering the fact thatVienna manuscript was written in 1439, Cairo manuscript was writtenbefore 1367 and Fergana manuscript was probably written in XIII.Century, we can clearly say that these three manuscripts were notwritten by Yūsuf Ḫāṣ Ḥācib or under his supervision. Therefore,research on Qutadgu Bilig text manuscripts should have started withthe detailed edition of all manuscripts. After detecting the features ofeach manuscript, researchers should start forming the „main text’ about‘the text which was written by the author himself’. Kutadgu Bilig hakkında günümüze değin birçok araştırma ve monografi çalışması hazırlanmış, ancak bu araştırmaların çok az bir kısmı eserin

  12. Gene Expression Profiling on Acute Rejected Transplant Kidneys with Microarray

    Institute of Scientific and Technical Information of China (English)

    Deping LI; Kang WANG; Yong DAI; Tianyu LV

    2008-01-01

    To investigate the gene expression profiles in acute allograft rejection of renal trans- plantation, and identify the markers for the early diagnosis of acute rejection, heterotopic kidney transplantation was performed by using F344 or Lewis donors and Lewis recipients. No immunosup- pressant was used. Renal grafts were harvested on days 3, 7, and 14. A commercial microarray was used to measure gene expression levels in day-7 grafts. The expression levels of 48 genes were up-regulated in the allograft in comparison with the isograft control, and interferon-y-induced GTPase gene was most significantly up-regulated in allografts. It is concluded that a variety of pathways are involved in organ transplant rejection which is dynamic and non-balanced. IFN-inducible genes, such as IGTP, may play an important role in the rejection. A lot of important factors involved in acute re- jection are unnecessary but sufficient conditions for the rejection. We are led to conclude that it is virtually impossible to make an early diagnosis based on a single gene marker, but it could he achieved on the basis of a set of markers.

  13. Rejection mechanisms for contaminants in polymeric reverse osmosis membranes

    CERN Document Server

    Shen, Meng; Lueptow, Richard M

    2016-01-01

    Despite the success of reverse osmosis (RO) for water purification, the molecular-level physico-chemical processes of contaminant rejection are not well understood. Here we carry out NEMD simulations on a model polyamide RO membrane to understand the mechanisms of transport and rejection of both ionic and neutral contaminants in water. We observe that the rejection changes non-monotonously with ion sizes. In particular, the rejection of urea, 2.4 A radius, is higher than ethanol, 2.6 A radius, and the rejections for organic solutes, 2.2-2.8 A radius, are lower than Na+, 1.4 A radius, or Cl-, 2.3 A radius. We show that this can be explained in terms of the solute accessible intermolecular volume in the membrane and the solute-water pair interaction energy. If the smallest open spaces in the membrane's molecular structure are all larger than the hydrated solute, then the solute-water pair interaction energy does not matter. However, when the open spaces in the polymeric structure are such that solutes have to s...

  14. Amino acid rejection behaviour as a function of concentration.

    Science.gov (United States)

    Shirley, Jason; Mandale, Stephen; Williams, Paul M

    2011-05-11

    The solute rejection versus concentration behaviour of five different amino acids has been investigated using a Nitto Denko NTR7450 nanofiltration membrane. The experimental data for amino acid rejection was also compared against a combined steric and charge rejection model. At its isoelectric point, lysine was effectively neutral and its behaviour was well described by the model incorporating a steric function only. For phenylalanine, the combined model was found to fit the data well. In contrast there was poor agreement between the model and rejection data for glutamine, glutamic acid and glycine whose rejection values at first increased with concentration. This result implied that another governing process was in operation. Dimerisation as an explanation for the observed phenomena was also investigated. Size analysis of amino acid molecules as a function of the prevailing concentration using dynamic light scattering was limited but showed no evidence of dimerisation. This data was supported by osmotic pressure measurements which demonstrated no evidence of non-linearity in the relation between osmotic pressure and concentration.

  15. The Register of Slovenian-Language Manuscripts from the 17th and 18th Centuries: Repository, Digital Library and Research Environment

    Directory of Open Access Journals (Sweden)

    Matija Ogrin

    2013-09-01

    Full Text Available EXTENDED ABSTRACT:The paper gives a thorough examination of the Register of Slovenian-language manuscripts from the 17th and 18th centuries from different points of view: it is presented as a digital repository in humanities disciplines available for searching (digital library and as a methodological framework of further scholarly research and discoveries in the field. Manuscripts, especially the manuscripts of Slovenian literature, have not been sufficiently taken into consideration so far. They have always been given but a sketchy treatment serving merely to illustrate the general outlines of the nation’s literary and cultural development. They have rarely been dealt with in specialised studies or scientific publications. This is the reason why they have not been registered and recorded in archival and library collections. Different guides to manuscripts offer only basic and limited information from which it is often impossible to identify the language, the content, and the history of a manuscript. With regard to the state-of-the- art of Slovenian manuscript research in the field of Slavic studies, archival studies and codicology, it was indispensable to thoroughly record and research the preserved manuscripts by the use of a uniform, rational and consistent method. In reference to these premises a new research project has been started resulting in accurate, thorough and rigorously structured descriptions of manuscripts. The idea of Slovenian manuscript register was developed comprising manuscript descriptions complemented by digital images or facsimiles thus visually presenting the manuscripts and facilitating further research in the field.The 3-year work resulted in the portal: Unknown Slovenian-language manuscripts from the 17th and 18 th centuries. The main project result was the register of Slovenian-language manuscripts from the 17th and 18th centuries. To date, it contains detailed descriptions of the first 100 manuscripts and over 7

  16. A Two-stage approach to harmonic rejection mixing using blind interference cancelling

    NARCIS (Netherlands)

    Moseley, N.A.; Klumperink, Eric A.M.; Nauta, Bram

    2008-01-01

    Abstract—Current analog harmonic rejection mixers typically provide 30–40 dB of harmonic rejection, which is often not sufficient. We present a mixed analog-digital approach to harmonic rejection mixing that uses a digital interference canceler to reject the strongest interferer. Simulations indicat

  17. Vicarious Group-Based Rejection : Creating a Potentially Dangerous Mix of Humiliation, Powerlessness, and Anger

    NARCIS (Netherlands)

    Veldhuis, Tinka M.; Gordijn, Ernestine H.; Veenstra, Rene; Lindenberg, Siegwart

    2014-01-01

    Rejection can convey that one is seen as inferior and not worth bothering with. Is it possible for people to feel vicariously rejected in this sense and have reactions that are similar to those following personal rejection, such as feeling humiliated, powerless, and angry? A study on personal reject

  18. Active disturbance rejection control for fractional-order system.

    Science.gov (United States)

    Li, Mingda; Li, Donghai; Wang, Jing; Zhao, Chunzhe

    2013-05-01

    Fractional-order proportional-integral (PI) and proportional-integral-derivative (PID) controllers are the most commonly used controllers in fractional-order systems. However, this paper proposes a simple integer-order control scheme for fractional-order system based on active disturbance rejection method. By treating the fractional-order dynamics as a common disturbance and actively rejecting it, active disturbance rejection control (ADRC) can achieve the desired response. External disturbance, sensor noise, and parameter disturbance are also estimated using extended state observer. The ADRC stability of rational-order model is analyzed. Simulation results on three typical fractional-order systems are provided to demonstrate the effectiveness of the proposed method.

  19. Prostanoids modulate inflammation and alloimmune responses during graft rejection

    Directory of Open Access Journals (Sweden)

    P.N. Rocha

    2005-12-01

    Full Text Available Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief overview of the alloimmune response, of prostanoid biology, and discuss the available evidence for the role of prostaglandin E2 and thromboxane A2 in graft rejection.

  20. The mechanisms of rejection in solid organ transplantation.

    Science.gov (United States)

    Cozzi, Emanuele; Colpo, Anna; De Silvestro, Giustina

    2017-08-01

    Organ transplantation represents the preferred treatment option for many patients in terminal organ failure. The half-life of transplanted organs, however, is still far from being satisfactory with the vast majority of the organs failing within the first two decades following transplantation. At this stage, it has become apparent that rejection (prevalently mediated by humoral events) remains the primary cause of graft loss after the first year. In this light, studies are underway to better comprehend the immune events underlying graft rejection and novel immunosuppressive strategies are being explored. In this context, therapeutic apheresis techniques, that include therapeutic plasma exchange (TPE), immunoadsorption (IA) and extracorporeal photochemotherapy (ECP), represent an important adjunct in the current immunosuppressive armamentarium. This article briefly reviews our current understanding of the immune process underlying rejection of a solid organ transplant and describes the principal areas of application of therapeutic apheresis techniques in transplantation. Copyright © 2017. Published by Elsevier Ltd.

  1. Rejected! Cognitions of rejection and intergroup anxiety as mediators of the impact of cross-group friendships on prejudice.

    Science.gov (United States)

    Barlow, Fiona Kate; Louis, Winnifred R; Hewstone, Miles

    2009-09-01

    In a sample of White Australians (N=273), cross-group friendship with Aboriginal Australians was associated with reduced cognitions of rejection and intergroup anxiety, and these variables fully mediated the effect of cross-group friendship on conversational avoidance of sensitive intergroup topics, active avoidance of the outgroup, and old-fashioned prejudice. The novel mediator proposed here, cognitions of rejection, predicted intergroup anxiety, and also predicted the three outcome variables via intergroup anxiety. Over and above its indirect effects via anxiety, cognitions of rejection directly predicted both conversational and active avoidance, suggesting that whilst the cognitive and affective mediators are linked, they predict intergroup outcomes in different ways. The results demonstrate the beneficial impact of cross group friendship in reducing prejudice and avoidance by diminishing cognitions of rejection and intergroup anxiety. We also highlight that individuals without cross-group friends may perceive the outgroup as rejecting, feel anxious about cross-group interaction, and desire both conversational and physical avoidance of the outgroup.

  2. A Longitudinal Study of Rejecting and Autonomy-Restrictive Parenting, Rejection Sensitivity, and Socioemotional Symptoms in Early Adolescents.

    Science.gov (United States)

    Rowe, Susan L; Gembeck, Melanie J Zimmer; Rudolph, Julia; Nesdale, Drew

    2015-08-01

    Rejection sensitivity (RS) has been defined as the tendency to readily perceive and overreact to interpersonal rejection. The primary aim of this study was to test key propositions of RS theory, namely that rejecting experiences in relationships with parents are antecedents of early adolescents' future RS and symptomatology. We also expanded this to consider autonomy-restrictive parenting, given the importance of autonomy in early adolescence. Participants were 601 early adolescents (age 9 to 13 years old, 51% boys) from three schools in Australia. Students completed questionnaires at school about parent and peer relationships, RS, loneliness, social anxiety, and depression at two times with a 14-month lag between assessments. Parents also reported on adolescents' difficulties at Time 1 (T1). It was anticipated that more experience of parental rejection, coercion, and psychological control would be associated with adolescents' escalating RS and symptoms over time, even after accounting for peer victimisation, and that RS would mediate associations between parenting and symptoms. Structural equation modelling supported these hypotheses. Parent coercion was associated with adolescents' increasing symptoms of social anxiety and RS over time, and parent psychological control was associated with increasing depressive symptoms over time. Indirect effects via RS were also found, with parent rejection and psychological control linked to higher T1 RS, which was then associated with increasing loneliness and RS. Lastly, in a separate model, peer victimisation and RS, but not parenting practices, were positively associated with concurrent parent reports of adolescents' difficulties.

  3. Analysis of Turbine Load Rejection for APR1400 using SPACE

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang Jin; Park, Chan Eok; Choi, Jong Ho; Lee, Gyu Cheon [KEPCO Engineering and Construction Co. Ltd., Deajeon (Korea, Republic of)

    2016-10-15

    Turbine Load Rejection event is one of the Performance Related Design Basis Event (PRDBE) that can be stabilized using plant control systems without any safety system actuation. The initiation of the event is turbine load rejection from 100% to 5% in 0.019 seconds. The NSSS control systems of APR1400 is composed of the Power Control System (PCS) and the Process-Component Control System (P-CCS). The PCS includes Reactor Regulating System (RRS), Reactor Power Cutback System (RPCS) and Digital Rod Control System (DRCS). The P-CCS includes the Pressurizer Pressure Control System (PPCS), the Pressurizer Level Control System (PLCS), the Feedwater Control System (FWCS) and the Steam Bypass Control System (SBCS). Turbine load rejection results in the increase of secondary pressure due to sudden blocking of steam flow to turbine. Then the Reactor Coolant System (RCS) cooling through steam generators is decreased rapidly and the RCS temperature will be increased. Turbine load rejection is a typical event to test NSSS control systems since it requires the automatic response of all major NSSS control systems. It is shown that the NSSS control systems of APR1400 have the capability to stabilize the plant without any safety system actuation for turbine load rejection event. This analysis results show that SPACE code has the capability to analyze the turbine load rejection event. However, further validation is necessary for other PRDBEs such as Two Main Feedwater Pumps Trip, Turbine Load Step Change and Turbine Load Ramp Down (5%/min) to verify the capability of SPACE for the full range of performance analyses.

  4. [On the astrology and computation in the 12th century: new unpublished manuscripts ].

    Science.gov (United States)

    Caiazzo, Irene

    2012-01-01

    This article examines three so far unknown lemmatic commentaries on computus and on astrolabe topics, which are to be found in MS Stuttgart, Württembergische Landesbibliothek, Cod. math. 4 degrees 33 (second half of the twelfth-century). The commentaries are on the 'Compotus' by Gerlandus, on the 'De mensura astrolabii' by Hermann of Reichenau, and on the 'De utilitatibus astrolabii', which is sometimes attributed to Gerbert of Aurillac. No commentaries on the respective treatises have previously been identified as such. The commentaries of the Stuttgart manuscript are of special interest in that they allow us to understand how a twelfth-century scholar read works on computus and the astrolabe, namely works that date back to the eleventh century. Their author remains anonymous, but in all probability he wrote his commentary on the 'Compotus' by Gerlandus either in 1143 or in 1150. An appendix to the article includes transcriptions of the introductory texts on the computus and on the astrolabe as well as the beginnings of the commentaries.

  5. A combined approach for the attribution of handwriting: the case of Antonio Stradivari's manuscripts

    Science.gov (United States)

    Fichera, Giusj Valentina; Dondi, Piercarlo; Licchelli, Maurizio; Lombardi, Luca; Ridolfi, Stefano; Malagodi, Marco

    2016-11-01

    Numerous artefacts from Antonio Stradivari's workshop are currently preserved in the "Museo del Violino" (Museum of the Violin) in Cremona, Italy. A large number of them are paper models containing instructions and technical notes by the great violin maker. After his death, this collection has had several owners, while new annotations added to the original ones, sometimes imitating Stradivari's handwriting, caused problems of authenticity. The attribution of these relics is a complex task and, until now, only a small part of them has been examined by palaeographers. This paper introduces a multi-analytical approach able to facilitate the study of handwriting in manuscripts with the combined use of image processing and X-ray fluorescence spectroscopy: the former provides a fast and automatic screening of documents; the latter allows to analyse the chemical composition of inks. For our tests, 17 paper relics, dated between 1684 and 1729, were chosen. Palaeographic analysis was used as reference. The results obtained showed the validity of the combined approach proposed herein: the two techniques proved to be complementary and useful to clarify the attribution of different pieces of handwriting.

  6. Distributing Images and Information over the Web - a Case Study of the Pont Manuscript Maps

    Directory of Open Access Journals (Sweden)

    Christopher Fleet

    2000-07-01

    Full Text Available Technological changes in recent years have encouraged many libraries to deliver digital images of their materials over the Internet. For larger items, including maps, high resolution images of research quality can now be obtained from steadily cheaper equipment, computers can process larger images more comfortably, and newer compression formats have allowed these images to be viewed interactively online. The exponential growth of the Internet has also created a large body of users who wish to access these images from their homes or desktops. Within this context, this paper describes the scanning of the Pont manuscript maps of Scotland, the technology used to make these maps available over the Internet, and the initial stages of the construction of a website of associated information. This case study is not presented as a prescriptive example of best practice, but rather as an illustration of some of the main practical issues involved, using these to present arguments for and against current map digitisation and Web delivery work.

  7. NINETEENTH-CENTURY MANUSCRIPTS OF THE CASTRO-PR: THE CASE OF RAISING

    Directory of Open Access Journals (Sweden)

    Dayme Rosane BENÇAL

    2015-06-01

    Full Text Available This study focuses on the alternations of mid vowels /e/ and /o/ in the pretonic context, respectively, present in the XIX century manuscripts belonging to Castro - Paraná. As this kind of oscillation, called raising, is not a recent process in the Portuguese language, we seek for evidences of Labov uniformitarianism when describing the cases found in XIX century formal documents in comparison to the data of orality, made available by Bisol (1981 Viegas (1987, 2001 Bortoni et. al (1992, Kailer (2008. For this, we use the precepts of Historical Linguistics, joined to the Varionist theory, since we associate the qualitative approach to quantitative one, based on the structural perspective to the historical-social. The results indicated the vowel harmonization process as the main context for the application of the rule, followed by initial nasal context according to the data of orality. The precedent labiodental consonant and the next bilabial following the pretonic were more productive for /e/ and the precedent alveolar for /o/. Not all words fit into the structural rules, then, the individual investigation directed us to the realization that both neogrammarian position as the diffusionist one have importance in the investigation of variation and language change.

  8. The Scientific Manuscripts left Unpublished by Ettore Majorana (with outlines of his life and work)

    CERN Document Server

    Recami, Erasmo

    2007-01-01

    We present a panoramic view of the main scientific manuscripts left unpublished by the brightest Italian theoretical physicist of the XX century, Ettore Majorana. We deal in particular: (i) with his very original "study" notes (the so-called "Volumetti"), already published by us in English, in 2003, c/o Kluwer Acad.Press, Dordrecht & Boston, and in the original Italian language, in 2006, c/o Zanichelli pub., Bologna, Italy; and (ii) with a selection of his research notes (the so-called "Quaderni"), that we shall publish c/o Springer, Berlin. We seize the present opportunity for setting forth also some suitable -scarcely known- information about Majorana's life and work, on the basis of documents (letters, testimonies, different documents...) discovered or collected by ourselves during the last decades. [A finished, enlarged version of this paper will appear as the editors' Preface, at the beginning of the coming book "Ettore Majorana - Unpublished Research Notes on Theoretical Physics", edited by S.Esposi...

  9. [A brief history of time: 1945-2008--studies, manuscripts, and publications].

    Science.gov (United States)

    Matsumoto, Tadahiko

    2009-01-01

    I (the author), Tadahiko Matsumoto, who is a winner of the 2008 Japanese Society for Medical Mycology (JSMM) Award, was born in 1945 and graduated in 1969 from Kyushu University in Fukuoka, Japan with an M.D. degree. At the Department of Dermatology, Kyushu University I studied dermatology and medical mycology. In Tokyo (1970-1971) at the Department of Microbiology, National Institute of Hygienic Sciences I learned general mycology. During the period from 1981 to 1983 I further studied medical mycology at the Division of Mycotic Diseases (Director: Dr. Libero Ajello), Center for Infectious Diseases, Centers for Disease Control (CDC) in Atlanta, Georgia in the United States. During the period from 1991 to 2005 while working as Director of Dermatology of Toshiba Hospital in Tokyo I was affiliated with several medical schools as a clinical and adjunct professor. Being a unique physician-scientist eager to publish my manuscripts in highly-regarded mycology journals, my studies were accurately reported as to description, taxonomy, and identification. My articles were published in journals carefully chosen for my purposes. As I became better known, I was frequently invited to contribute review articles in leading journals and chapters in authoritative textbooks of dermatology, infectious diseases, and microbiology. I was also invited to be a member and/or chairperson of various symposia in international congresses and one of the lecturers in seminars. I have established many friendly personal relationships among scientists, and we are always ready to help each other whenever necessary.

  10. Weighing brain activity with the balance: Angelo Mosso's original manuscripts come to light.

    Science.gov (United States)

    Sandrone, Stefano; Bacigaluppi, Marco; Galloni, Marco R; Cappa, Stefano F; Moro, Andrea; Catani, Marco; Filippi, Massimo; Monti, Martin M; Perani, Daniela; Martino, Gianvito

    2014-02-01

    Neuroimaging techniques, such as positron emission tomography and functional magnetic resonance imaging are essential tools for the analysis of organized neural systems in working and resting states, both in physiological and pathological conditions. They provide evidence of coupled metabolic and cerebral local blood flow changes that strictly depend upon cellular activity. In 1890, Charles Smart Roy and Charles Scott Sherrington suggested a link between brain circulation and metabolism. In the same year William James, in his introduction of the concept of brain blood flow variations during mental activities, briefly reported the studies of the Italian physiologist Angelo Mosso, a multifaceted researcher interested in the human circulatory system. James focused on Mosso's recordings of brain pulsations in patients with skull breaches, and in the process only briefly referred to another invention of Mosso's, the 'human circulation balance', which could non-invasively measure the redistribution of blood during emotional and intellectual activity. However, the details and precise workings of this instrument and the experiments Mosso performed with it have remained largely unknown. Having found Mosso's original manuscripts in the archives, we remind the scientific community of his experiments with the 'human circulation balance' and of his establishment of the conceptual basis of non-invasive functional neuroimaging techniques. Mosso unearthed and investigated several critical variables that are still relevant in modern neuroimaging such as the 'signal-to-noise ratio', the appropriate choice of the experimental paradigm and the need for the simultaneous recording of differing physiological parameters.

  11. Choosing a scholarly journal during manuscript submission: the way how it rings true for physiatrists.

    Science.gov (United States)

    Özçakar, L; Franchignoni, F; Kara, M; Muñoz Lasa, S

    2012-12-01

    Research and publications are increasing in Physical and Rehabilitation Medicine (PRM). Hence, there appears to be a multifaceted and challenging turnover in our scientific niche involving authors, editors, publishers and readers in a complex interplay. To explore the manuscript submission process from the side of the authors, and to better understand their perceptions and preferences. A survey study. E-mail and personal contact. European researchers working in the field of PRM. A questionnaire was specifically prepared for this study. The first part included questions regarding personal and scientific background; in the second part the attendants rated 20 items (with respect to several journal characteristics) on a 4-point semantic differential scale; and the third part contained two open ended questions regarding additional factors that the authors considered during submission. Area of interest (mission and contents) of the journal within the "Rehabilitation" category, absolute impact factor of the journal, match between perceived "quality" of their study and journal impact factor were considered to be the three most important factors by the authors. In a scientific environment where the numbers of research and publication outlets alike are growing, it is important to understand how authors choose where to publish their papers. We believe that editors, and publishers as well, would take into account our findings to best meet the needs of all actors in the competitive marketplace of scholarly publishing in PRM.

  12. SharedCanvas: A Collaborative Model for Medieval Manuscript Layout Dissemination

    CERN Document Server

    Sanderson, Robert; Schwemmer, Rafael; Van de Sompel, Herbert

    2011-01-01

    In this paper we present a model based on the principles of Linked Data that can be used to describe the interrelationships of images, texts and other resources to facilitate the interoperability of repositories of medieval manuscripts or other culturally important handwritten documents. The model is designed from a set of requirements derived from the real world use cases of some of the largest digitized medieval content holders, and instantiations of the model are intended as the input to collection-independent page turning and scholarly presentation interfaces. A canvas painting paradigm, such as in PDF and SVG, was selected based on the lack of a one to one correlation between image and page, and to fulfill complex requirements such as when the full text of a page is known, but only fragments of the physical object remain. The model is implemented using technologies such as OAI-ORE Aggregations and OAC Annotations, as the fundamental building blocks of emerging Linked Digital Libraries. The model and impl...

  13. News on a manuscript of The tribunal de la justa venganza

    Directory of Open Access Journals (Sweden)

    María José Alonso Veloso

    2017-07-01

    Full Text Available This article aims to give notice about the existence of a manuscript from the 17th century that copies the invective titled El tribunal de la justa venganza. This work was published against Quevedo in 1635 and its author remains hidden behind the pseudonym “Arnaldo Franco-Furt”. This new testimony, kept in the National Library of Portugal, in Lisbon, is very interesting for the critical edition of the controversial text, due to its early dating and its suitable readings in wrong passages of the princeps. The Tribunal has been always edited according to a single document, the first edition, which does not seem to have been the model for the handwritten copy. Additionally, this unknown textual source contributes to draw critical attention to one aspect that had gone unnoticed until now: the possible falsification of data concerning the place and the printer of the invective (Valencia, “Herederos of Philip Mey”, a hypothesis still needed of further inquiries.

  14. The art of scientific storytelling transform your research manuscript using a step-by-step formula

    CERN Document Server

    Luna, Rafael E

    2013-01-01

    We all want our research to have an impact and to be cited by others. There are thousands of research articles published in our respective fields. How do we get someone to read our publications? This book shows you how to put your Title and Abstract into a story, along with the rest of your manuscript. Your research will stand out in a sea of peer-review publications, since it will be forged into a Scientific Story. As a research fellow in the laboratory of Professor Gerhard Wagner at Harvard Medical School, Dr. Luna was collaborating with four other top-notch laboratories in an interdisciplinary research effort to understand the end of the scanning mechanism required for protein synthesis in cells. They were sitting on a mound of research data collected by the various laboratories with varying expertise. This super-collaboration consisted of Physicists, Biologists, Structural Biologists, Biochemists, Chemists, a Computer Scientist, and a Chemical Engineer. There was so much data; yet they struggled to fashio...

  15. No miniatures, not even decoration, yet extraordinarily fascinating! New hypotheses concerning the Lancelot Compilation and related manuscripts

    NARCIS (Netherlands)

    Biemans, J.A.A.M.

    2009-01-01

    This essay sheds new light on the controversial fourteenth-century poet and compiler Lodewijk van Velthem. Specifically, the article considers the possible relationships between The Hague, Koninklijke Bibliotheek, MS 129 A 10, the manuscript containing the famous Lancelot Compilation, and Leiden, Un

  16. There Was a Crooked Man(uscript): A Not-so-Serious Look at the Serious Subject of Plagiarism

    Science.gov (United States)

    McGuire, Kevin T.

    2010-01-01

    The problem of plagiarism by political scientists has not received much attention. The incidence of plagiarism, however, may be greater than one would think. In this article, I offer a humorous look at what happened when a manuscript of mine was plagiarized. Based on my experience, I offer some suggestions on how scholars might detect and prevent…

  17. A Response to Matsuda and Tardy's "Voice in Academic Writing: The Rhetorical Construction of Author Identity in Blind Manuscript Review"

    Science.gov (United States)

    Stapleton, Paul; Helms-Park, Rena

    2008-01-01

    In a recent article in ESP, Matsuda and Tardy (2007) investigate the role of voice in academic writing via a simulated blind manuscript review process. Based on their findings, they claim that voice does play a role in such writing, and call for further research into the issue of the reader's construction of authorial identity. Matsuda and Tardy's…

  18. Keats’s sonnet on Chapman’s translation of Homer: manuscript of early draft and initial publication

    Directory of Open Access Journals (Sweden)

    Brian Franklin Head

    2016-08-01

    Full Text Available This study presents the earliest known manuscript of Keats's sonnet to Chapman’s translation of the Iliad (1611, in comparison with the first publication of the poem by Keats (1816. A comparative reading is provided, along with related philological and literary comments.

  19. The Old Saxon Leipzig "Heliand" Manuscript Fragment (MS L): New Evidence Concerning Luther, the Poet, and Ottonian Heritage

    Science.gov (United States)

    Price, Timothy Blaine

    2010-01-01

    Begun as an investigation of the linguistic and paleographic evidence on the Old Saxon Leipzig "Heliand" fragment, the dissertation encompasses three analyses spanning over a millennium of that manuscript's existence. First, a direct analysis clarifies errors in the published transcription (4.2). The corrections result from digital…

  20. Development of an Augmented Reality Rare Book and Manuscript for Special Library Collection (AR Rare-BM)

    Science.gov (United States)

    Parhizkar, Behrang; Badioze Zaman, Halimah

    This research aims to study the development of augmented reality of rare books or manuscripts of special collections in the libraries. Augmented reality has the ability to enhance users' perception of and interaction with the real world. Libraries has to ensure that this special collection is well handled as these rare books and manuscripts are priceless as they represent the inheritance of each nation. The use of augmented reality will be able to model these valuable manuscripts and rare books and appear as augmented reality to ensure that the collection can be better maintained. Users will be able to open the augmented rare book, and flip the pages, as well as read the contents of the rare books and manuscripts using the peripheral equipment such as the HMD or the Marker. The AR Rare-BM developed is modeled as an augmented reality that allows users to put the augmented rare book on his palm or table and manipulate it while reading. Users can also leave a bookmark in the AR Rare-BM after reading so that they can read their favourite sections again at a later date.

  1. Hesitating progress - the slow development toward algebraic symbolization in abbacus- and related manuscripts, c.1300 to c.1550

    DEFF Research Database (Denmark)

    Høyrup, Jens

    From the early fourteenth century onward, some Italian Abbacus manuscripts begin to use particular abbreviations for algebraic operations and objects and, to be distinguished from that, examples of symbolic operation. The algebraic abbreviations and symbolic operations we find in German Rechenmei...

  2. EFFECT OF TIME OF TRANSITION FROM MANUSCRIPT TO CURSIVE WRITING UPON SUBSEQUENT PERFORMANCE IN HANDWRITING, SPELLING, AND READING.

    Science.gov (United States)

    OTTO, WAYNE; RARICK, G. LAWRENCE

    THE RELATIONSHIP OF THE HANDWRITING, READING, AND SPELLING PERFORMANCE OF FOURTH- AND SIXTH-GRADE CHILDREN TO THE TRANSITION TIME FROM MANUSCRIPT TO CURSIVE WRITING WAS STUDIED. THE FOUR TRANSITION TIMES WERE EITHER THE FIRST OR SECOND SEMESTER IN GRADE 2 OR THE FIRST OR SECOND SEMESTER IN GRADE 3. HANDWRITING LEGIBILITY WAS MEASURED BY THE…

  3. Biographical introduction, Summary of Contents (manuscript version), Summary of Contents (Latin edition) and Summary of Contents (German edition)

    OpenAIRE

    Aspaas, Per Pippin

    2016-01-01

    This file contains a biographical introduction on Maximilianus (Maximilian) Hell (1720-1792) followed by summaries of contents of all three known versions of his treatise on the Aurora Borealis, the 'Lucis Boreæ Theoria nova' (manuscript version, c. 1770), 'Aurorae Borealis Theoria Nova' (Latin edition, 1776) and 'Neue Theorie des Nordlichtes' (German edition, 1792).

  4. Peer Review in Agricultural Education: Interrater Reliability of Manuscript Reviews for the 2014 National Agricultural Education Research Conference

    Science.gov (United States)

    Shoulders, Catherine W.; Johnson, Donald M.; Flowers, Jim

    2015-01-01

    This study analyzed 336 peer reviews of 112 manuscripts submitted for possible presentation at the 2014 National Agricultural Education Research Conference (NAERC). There were scoring errors on 6.8% of the reviews; the most frequent errors were failure to record a score or assigning a score above the range of points possible for one or more of the…

  5. There Was a Crooked Man(uscript): A Not-so-Serious Look at the Serious Subject of Plagiarism

    Science.gov (United States)

    McGuire, Kevin T.

    2010-01-01

    The problem of plagiarism by political scientists has not received much attention. The incidence of plagiarism, however, may be greater than one would think. In this article, I offer a humorous look at what happened when a manuscript of mine was plagiarized. Based on my experience, I offer some suggestions on how scholars might detect and prevent…

  6. Belief decision support and reject for textured images characterization

    CERN Document Server

    Martin, Arnaud

    2008-01-01

    The textured images' classification assumes to consider the images in terms of area with the same texture. In uncertain environment, it could be better to take an imprecise decision or to reject the area corresponding to an unlearning class. Moreover, on the areas that are the classification units, we can have more than one texture. These considerations allows us to develop a belief decision model permitting to reject an area as unlearning and to decide on unions and intersections of learning classes. The proposed approach finds all its justification in an application of seabed characterization from sonar images, which contributes to an illustration.

  7. Method and apparatus for analog pulse pile-up rejection

    Science.gov (United States)

    De Geronimo, Gianluigi

    2013-12-31

    A method and apparatus for pulse pile-up rejection are disclosed. The apparatus comprises a delay value application constituent configured to receive a threshold-crossing time value, and provide an adjustable value according to a delay value and the threshold-crossing time value; and a comparison constituent configured to receive a peak-occurrence time value and the adjustable value, compare the peak-occurrence time value with the adjustable value, indicate pulse acceptance if the peak-occurrence time value is less than or equal to the adjustable value, and indicate pulse rejection if the peak-occurrence time value is greater than the adjustable value.

  8. Active Disturbance Rejection Control of a Heat Integrated Distillation Column

    DEFF Research Database (Denmark)

    Al-Kalbani, Fahad; Zhang, Jie; Bisgaard, Thomas;

    2016-01-01

    pressure. However, the control of some HiDC processesis generally difficult due to the strong control loop interaction, high purity of the components and undesired disturbances. Active disturbance rejection control (ADRC) is used in this paperto control a simulated HiDC for separating benzene......-toluene mixture. The efficiency of the ADRC technique is demonstrated by comparing with the conventional PI controller in terms of set-point trackingand external disturbance rejection capability. The results show that the ADRC gives much improved control performance than the PID control....

  9. Multiquadrant Subtenon Triamcinolone Injection for Acute Corneal Graft Rejection: A Case Report

    Directory of Open Access Journals (Sweden)

    Sunali Goyal

    2017-05-01

    Full Text Available Background: We report a case of reversal of an acute corneal graft rejection following multiquadrant subtenon triamcinolone injection. Case Presentation: A 19-year-old woman who had acute corneal graft rejection failed to show resolution of the graft rejection after standard treatment with systemic, intravenous, and topical steroids. The graft rejection, however, responded to injection of triamcinolone in multiple subtenon quadrants. Conclusions: For corneal graft rejection, multiquadrant subtenon triamcinolone injections may be a safe adjunct to systemic treatment.

  10. JOURNAL CLUB: Plagiarism in Manuscripts Submitted to the AJR: Development of an Optimal Screening Algorithm and Management Pathways.

    Science.gov (United States)

    Taylor, Donna B

    2017-04-01

    The objective of this study was to investigate the incidence of plagiarism in a sample of manuscripts submitted to the AJR using CrossCheck, develop an algorithm to identify significant plagiarism, and formulate management pathways. A sample of 110 of 1610 (6.8%) manuscripts submitted to AJR in 2014 in the categories of Original Research or Review were analyzed using CrossCheck and manual assessment. The overall similarity index (OSI), highest similarity score from a single source, whether duplication was from single or multiple origins, journal section, and presence or absence of referencing the source were recorded. The criteria outlined by the International Committee of Medical Journal Editors were the reference standard for identifying manuscripts containing plagiarism. Statistical analysis was used to develop a screening algorithm to maximize sensitivity and specificity for the detection of plagiarism. Criteria for defining the severity of plagiarism and management pathways based on the severity of the plagiarism were determined. Twelve manuscripts (10.9%) contained plagiarism. Nine had an OSI excluding quotations and references of less than 20%. In seven, the highest similarity score from a single source was less than 10%. The highest similarity score from a single source was the work of the same author or authors in nine. Common sections for duplication were the Materials and Methods, Discussion, and abstract. Referencing the original source was lacking in 11. Plagiarism was undetected at submission in five of these 12 articles; two had been accepted for publication. The most effective screening algorithm was to average the OSI including quotations and references and the highest similarity score from a single source and to submit manuscripts with an average value of more than 12% for further review. The current methods for detecting plagiarism are suboptimal. A new screening algorithm is proposed.

  11. Examining Appearance-Based Rejection Sensitivity during Early Adolescence

    Science.gov (United States)

    Bowker, Julie C.; Thomas, Katelyn K.; Spencer, Sarah V.; Park, Lora E.

    2013-01-01

    The present study of 150 adolescents ("M" age = 13.05 years) examined the associations between appearance-based rejection sensitivity (Appearance-RS) and psychological adjustment during early adolescence, and evaluated three types of other-gender peer experiences (other-gender friendship, peer acceptance, and romantic relationships) as…

  12. Examining Appearance-Based Rejection Sensitivity during Early Adolescence

    Science.gov (United States)

    Bowker, Julie C.; Thomas, Katelyn K.; Spencer, Sarah V.; Park, Lora E.

    2013-01-01

    The present study of 150 adolescents ("M" age = 13.05 years) examined the associations between appearance-based rejection sensitivity (Appearance-RS) and psychological adjustment during early adolescence, and evaluated three types of other-gender peer experiences (other-gender friendship, peer acceptance, and romantic relationships) as…

  13. Pretransplant identification of acute rejection risk following kidney transplantation

    NARCIS (Netherlands)

    Y. Lebranchu (Yvon); C.C. Baan (Carla); L. Biancone (Luigi); C. Legendre (Christophe); J.M. Morales (José Maria); L. Naesens; O. Thomusch (Oliver); P. Friend (Peter)

    2014-01-01

    textabstractLack of an accepted definition for 'high immunological risk' hampers individualization of immunosuppressive therapy after kidney transplantation. For recipient-related risk factors for acute rejection, the most compelling evidence points to younger age and African American ethnicity. Rec

  14. Pretransplant identification of acute rejection risk following kidney transplantation.

    Science.gov (United States)

    Lebranchu, Yvon; Baan, Carla; Biancone, Luigi; Legendre, Christophe; Morales, José Maria; Naesens, Maarten; Thomusch, Oliver; Friend, Peter

    2014-02-01

    Lack of an accepted definition for 'high immunological risk' hampers individualization of immunosuppressive therapy after kidney transplantation. For recipient-related risk factors for acute rejection, the most compelling evidence points to younger age and African American ethnicity. Recipient gender, body mass, previous transplantation, and concomitant infection or disease do not appear to be influential. Deceased donation now has only a minor effect on rejection risk, but older donor age remains a significant predictor. Conventional immunological markers (human leukocyte antigen [HLA] mismatching, pretransplant anti-HLA alloantibodies, and panel reactive antibodies) are being reassessed in light of growing understanding about the role of donor-specific antibodies (DSA). At the time of transplant, delayed graft function is one of the most clear-cut risk factors for acute rejection. Extended cold ischemia time (≥ 24 h) may also play a contributory role. While it is not yet possible to establish conclusively the relative contribution of different risk factors for acute rejection after kidney transplantation, the available data point to variables that should be taken into account at the time of transplant. Together, these offer a realistic basis for planning an appropriate immunosuppression regimen in individual patients.

  15. Compact filtering monopole patch antenna with dual-band rejection.

    Science.gov (United States)

    Kim, Sun-Woong; Choi, Dong-You

    2016-01-01

    In this paper, a compact ultra-wideband patch antenna with dual-band rejection is proposed. The proposed antenna filters 3.3-3.8 GHz WiMAX and 5.15-5.85 GHz WLAN by respectively rejecting these bands through a C-shaped slit and a λg/4 resonator. The λg/4 resonator is positioned as a pair, centered around the microstrip line, and a C-type slit is inserted into an elliptical patch. The impedance bandwidth of the proposed antenna is 2.9-9.3 GHz, which satisfies the bandwidth for ultra-wideband communication systems. Further, the proposed antenna provides dual-band rejection at two bands: 3.2-3.85 and 4.7-6.03 GHz. The radiation pattern of the antenna is omnidirectional, and antenna gain is maintained constantly while showing -8.4 and -1.5 dBi at the two rejected bands, respectively.

  16. 48 CFR 619.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ... Small Business Administration recommendations. The Procurement Executive is the agency head for the... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 619.505 Section 619.505 Federal Acquisition Regulations System DEPARTMENT...

  17. 48 CFR 1319.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ... Small Business Administration recommendations. (a) The designee authorized to render a decision on the Small Business Administration's appeal of the contracting officer's decision is set forth in CAM 1301.70... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Rejecting Small...

  18. 48 CFR 814.404-2 - Rejection of individual bids.

    Science.gov (United States)

    2010-10-01

    ... reject the offer simply because it specifies a bid acceptance time that is shorter than that contained in... that the bid as submitted is in such a form that acceptance would create a valid and binding contract... determination that the bid as submitted is in such form that acceptance would not create a valid and...

  19. Shape Morphing Adaptive Radiator Technology (SMART) for Variable Heat Rejection

    Science.gov (United States)

    Erickson, Lisa

    2016-01-01

    The proposed technology leverages the temperature dependent phase change of shape memory alloys (SMAs) to drive the shape of a flexible radiator panel. The opening/closing of the radiator panel, as a function of temperature, passively adapts the radiator's rate of heat rejection in response to a vehicle's needs.

  20. Nucleic Acid Drugs for Prevention of Cardiac Rejection

    Directory of Open Access Journals (Sweden)

    Jun-ichi Suzuki

    2009-01-01

    Full Text Available Heart transplantation has been broadly performed in humans. However, occurrence of acute and chronic rejection has not yet been resolved. Several inflammatory factors, such as cytokines and adhesion molecules, enhance the rejection. The graft arterial disease (GAD, which is a type of chronic rejection, is characterized by intimal thickening comprised of proliferative smooth muscle cells. Specific treatments that target the attenuation of acute rejection and GAD formation have not been well studied in cardiac transplantation. Recent progress in the nucleic acid drugs, such as antisense oligodeoxynucleotides (ODNs to regulate the transcription of disease-related genes, has important roles in therapeutic applications. Transfection of cis-element double-stranded DNA, named as “decoy,” has been also reported to be a useful nucleic acid drug. This decoy strategy has been not only a useful method for the experimental studies of gene regulation but also a novel clinical strategy. In this paper, we reviewed the experimental results of NF-κB, E2F, AP-1, and STAT-1 decoy and other ODNs using the experimental heart transplant models.

  1. Tracking and disturbance rejection for fully actuated mechanical systems

    NARCIS (Netherlands)

    Jayawardhana, Bayu; Weiss, George

    2008-01-01

    In this paper, we solve the tracking and disturbance rejection problem for fully actuated passive mechanical systems. We assume that the reference signal r and its first two derivatives r, r are available to the controller and the disturbance signal d can be decomposed into a finite superposition of

  2. Perceived parental rejection mediates the effects of previous ...

    African Journals Online (AJOL)

    2017-06-30

    Jun 30, 2017 ... problems related to perceived parental rejection underlie the ... Childhood abuse can lead to the manifestation in later ... In the United States,. Moylan et ... schools were included in the study. ... International Neuropsychiatric Interview for Children and ... (emotional, physical and sexual abuse; emotional and.

  3. Noninvasive methods of rejection diagnosis after heart transplantation.

    Science.gov (United States)

    Kemkes, B M; Schütz, A; Engelhardt, M; Brandl, U; Breuer, M

    1992-01-01

    For clinical follow-up and prognosis in heart transplant patients, it is important to understand accurately the presence and extent of cardiac allograft rejection. Since the introduction of endomyocardial biopsy, almost 40 different noninvasive diagnostic procedures for the recognition of myocardial rejection have been proposed. However, endomyocardial biopsy is invasive and not suitable for frequent monitoring. If the pattern of rejection shows a focal distribution, false-negative results can be expected. Discrepancies between biopsy findings and allograft function are obviously possible. State-of-the-art information will be given on the most reliable noninvasive methods for rejection diagnosis, which can be differentiated from electrophysiology (fast-Fourier-transformed electrocardiography and intramyocardial electrocardiography), echocardiography, immunologic methods (cytoimmunologic monitoring, transferrin receptors, and interleukin-2 receptors), various biochemical markers (neopterines, prolactin, urinary polyamines, and beta 2-microglobulins), radioisotopic techniques (antimyosin-monoclonal antibodies, thallium, technetium, and gallium scintigraphy and indium-labeled cells), as well as magnetic resonance imaging. Thus modified and patient-adapted antirejection therapy can be provided if the decision for or against antirejection therapy is not based on biopsy findings alone but rather is confirmed along with histologic, electrophysiologic, biochemical, immunologic, and functional parameters.

  4. Rejected Ballots and Democratic Consolidation in Ghana's Fourth ...

    African Journals Online (AJOL)

    Nekky Umera

    This paper discusses the incidence of rejected ballots in Ghana since. 1992 and ..... Heritage Party (PHP) respectively garnered 2.86% and 1.76% of the valid ..... of the ballot papers by voters may lead to spoilt ballots as the ink may end up.

  5. Maternal Predictors of Rejecting Parenting and Early Adolescent Antisocial Behavior

    Science.gov (United States)

    Trentacosta, Christopher J.; Shaw, Daniel S.

    2008-01-01

    The present study examined relations among maternal psychological resources, rejecting parenting, and early adolescent antisocial behavior in a sample of 231 low-income mothers and their sons with longitudinal assessments from age 18 months to 12 years. The maternal resources examined were age at first birth, aggressive personality, and empathy.…

  6. The Heritage of Medieval Errors in the Latin Manuscripts of Johannes Hispalensis (John of Seville

    Directory of Open Access Journals (Sweden)

    Robinson, Maureen

    2007-06-01

    Full Text Available After the Christian reconquest of Islamic-held territory, many Arabic texts had to be translated into Latin in twelfth century Spain. Johannes Hispalensis (John of Seville knew both Arabic and Latin and worked alone, whereas others needed collaborators to complete the process. The duplication of Latin texts became popular and quickly spread. Over the following centuries, the medieval scribes involved made multiple copies of the manuscripts and during the reproduction process, many errors occurred. These contributed to confusion between the correct version of the translator's name and his identity. Consequently, Hispalensis appeared in later copies of his work with various titles such as “Master” or “Bishop”, or was coupled with a collaborator. Modern-day historians added to the complexities by creating one personality out of two diverse translators. At times, the ownership of some of the manuscripts rested solely on the names appearing in them, when only scribal errors had contributed them. An attempt is made to clarify the translations accredited to Johannes Hispalensis, working alone, and those working with collaborators.

    Después de la Reconquista, se tuvieron que traducir al latín muchos textos árabes en la España del siglo XII. La mayoría de los copistas necesitaban colaboradores para concluir el proceso, sin embargo, Johannes Hispalensis (Juan de Sevilla conocía tanto la lengua árabe como el latín, por lo que podía trabajar solo. La duplicación de textos latinos se popularizó y divulgó rápidamente. Durante los siglos siguientes, los copistas medievales hicieron múltiples copias, y durante el proceso de reproducción cometieron muchos errores que contribuyeron a la confusión entre la versión correcta del nombre del traductor y su identidad.  Por consiguiente, Hispalensis apareció en copias

  7. The memoirs of Vilnius bishop Adam Stanisław Krasiński: from manuscript to publication

    Directory of Open Access Journals (Sweden)

    Aldona Prašmantaitė

    2013-12-01

    Full Text Available Bishop of Vilnius Diocese Adam Stanisław Krasiński (1810–1891 left a deep imprint not only as an active hierarch of the Roman Catholic Church, but also as an energetic participant of 19th c. cultural life, a man of letters. Not complying with the instruction of Governor General Michael Murav’ev to issue a circular condemning the 1863 uprising, Krasiński in the early summer of 1863 was exiled to Vyatka (now Kirov. Released from exile in 1883, without the right to return to his diocese, Krasiński settled in Krakow. The period of the life of the bishop in Krakow from a creative point of view was very productive. From his youth interested in literature, having also been a man of letters, the preparer of a dictionary of Polish synonyms, Krasiński while living in Krakow began to write memoirs. For the first time the Memoirs [Wspomnienia] of the Bishop of Vilnius written in his native Polish were published in 1900 in the newspaper „Czas”, and in the same year 1900 (or in early 1901 the „Czas” publishing house issued them as a book with a press run of 150 copies. In the Memoirs there are interesting details from the history of the Piarist order, about the situation of the Roman Catholic Church in the lands of the former Polish-Lithuanian Commonwealth that after its collapse fell to the Russian Empire, and the literary and intellectual realities of life in Vilnius. The twenty years of exile are described very succinctly and the life in Krakow after returning from exile is not even mentioned at all. The paper reconstructs the path of the Vilnius Bishop’s memoirs from manuscript to printing at the beginning of the 20th c. While uncovering the circumstances of the writing and publishing of the Memoirs, it was determined that in the collections of the National Museum in Krakow since 1917 is stored not the manuscript of Krasiński ‘s memoirs, but its editorial version with fragments of the autograph. It is assumed that the original

  8. Rejection of false saturation data in optical pulse-oximeter

    Science.gov (United States)

    Scalise, Lorenzo; Marchionni, Paolo; Carnielli, Virgilio

    2010-04-01

    Pulse oximetry (PO) is a non-invasive medical device used for monitoring of the arterial oxygen saturation (SaO2) and in particular of haemoglobin oxygenation in blood. Oxygen saturation is commonly used in any setting where the patient blood oxygen saturation is unstable, including Neonatal Intensive Care Unit (NICU). The main factor affecting PO's output data is the presence of voluntary or involuntary motion artifacts or imperfect skin-sensor contact. Various methods have been employed to reject motion artifact but have met with little success. The aim of the present work is to propose a novel measurement procedure for real-time monitoring and validation of the oxygen saturation data as measured in standard pulse oxymeter. The procedure should be able to individuate and reject erroneous saturation data due to incorrect transducer-skin contact or motion artifact. In the case of short sequences of rejected SpO2 data (time durationoximeter (HRSAT) and the SpO2 value. In order to remove the erroneous SpO2 values reported in the rough data in coincidence of motion artifact (top, right), we have implemented a specific algorithm which provides at the output a new sequence of SpO2 data (validated SpO2 data). With the aim to "rescue" SpO2 value rejected by the previously presented algorithm, we have implemented an algorithm able to provide the "most-probable" SpO2 values in the case of single rejected values or in the case of short sequences of invalidated data (oximeter are not validated by the use of our method (corresponding to a total time of 16 hr, 8min and 40s). The use of the proposed algorithm aiming to "rescue" data from short sequences of rejected data (< 8s) allows to increase the validated data of the 2.5%t(equivalent to 8hr, 40 min and 16s), allowing a percent of usable data of the 95.7%. Once implemented in clinic, it could be used to identify the period of the day in which the percent of rejected data increase or correlate this data to clinical procedure

  9. Vicarious group-based rejection: creating a potentially dangerous mix of humiliation, powerlessness, and anger.

    Directory of Open Access Journals (Sweden)

    Tinka M Veldhuis

    Full Text Available Rejection can convey that one is seen as inferior and not worth bothering with. Is it possible for people to feel vicariously rejected in this sense and have reactions that are similar to those following personal rejection, such as feeling humiliated, powerless, and angry? A study on personal rejection was followed by two main studies on vicarious group-based rejection. It was found that merely observing rejection of ingroup members can trigger feelings of humiliation that are equally intense as those experienced in response to personal rejection. Moreover, given that the rejection is explicit, vicariously experienced feelings of humiliation can be accompanied by powerlessness and anger. Potentially, this combination of emotions could be an important source of offensive action against rejecters.

  10. Rejection Thresholds in Solid Chocolate-Flavored Compound Coating

    Science.gov (United States)

    Harwood, Meriel L.; Ziegler, Gregory R.; Hayes, John E.

    2012-01-01

    Classical detection thresholds do not predict liking, as they focus on the presence or absence of a sensation. Recently however, Prescott and colleagues described a new method, the rejection threshold, where a series of forced choice preference tasks are used to generate a dose-response function to determine hedonically acceptable concentrations. That is, how much is too much? To date, this approach has been used exclusively in liquid foods. Here, we determined group rejection thresholds in solid chocolate-flavored compound coating for bitterness. The influences of self-identified preferences for milk or dark chocolate, as well as eating style (chewers versus melters) on rejection thresholds were investigated. Stimuli included milk chocolate-flavored compound coating spiked with increasing amounts of sucrose octaacetate (SOA), a bitter GRAS additive. Paired preference tests (blank vs. spike) were used to determine the proportion of the group that preferred the blank. Across pairs, spiked samples were presented in ascending concentration. We were able to quantify and compare differences between two self-identified market segments. The rejection threshold for the dark chocolate preferring group was significantly higher than the milk chocolate preferring group (p = 0.01). Conversely, eating style did not affect group rejection thresholds (p = 0.14), although this may reflect the amount of chocolate given to participants. Additionally, there was no association between chocolate preference and eating style (p = 0.36). Present work supports the contention that this method can be used to examine preferences within specific market segments and potentially individual differences as they relate to ingestive behavior. PMID:22924788

  11. Identification and rejection of scattered neutrons in AGATA

    Energy Technology Data Exchange (ETDEWEB)

    Şenyiğit, M., E-mail: meneksek@science.ankara.edu.tr [Department of Physics, Faculty of Science, Ankara University, TR-06100 Tandoğan, Ankara (Turkey); Ataç, A. [Department of Physics, Faculty of Science, Ankara University, TR-06100 Tandoğan, Ankara (Turkey); Deptartment of Physics, Royal Institute of Technology, SE-10691 Stockholm (Sweden); Akkoyun, S. [Faculty of Science, Department of Physics, Cumhuriyet University, 58140 Sivas (Turkey); Kaşkaş, A. [Department of Physics, Faculty of Science, Ankara University, TR-06100 Tandoğan, Ankara (Turkey); Bazzacco, D. [INFN Sezione di Padova, I-35131 Padova (Italy); Dipartimento di Fisica e Astronomia dell' Università di Padova, I-35131 Padova (Italy); Nyberg, J. [Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala (Sweden); Recchia, F. [INFN Sezione di Padova, I-35131 Padova (Italy); Dipartimento di Fisica e Astronomia dell' Università di Padova, I-35131 Padova (Italy); Brambilla, S. [INFN Sezione di Milano, I-20133 Milano (Italy); Camera, F. [Universitá degli Studi di Milano via Celoria 16, 20133 Milano (Italy); INFN Sezione di Milano, I-20133 Milano (Italy); Crespi, F.C.L. [INFN Sezione di Milano, I-20133 Milano (Italy); Farnea, E. [INFN Sezione di Padova, I-35131 Padova (Italy); Dipartimento di Fisica e Astronomia dell' Università di Padova, I-35131 Padova (Italy); Giaz, A. [INFN Sezione di Milano, I-20133 Milano (Italy); Gottardo, A. [Laboratori Nazionali di Legnaro, INFN, I-35020 Legnaro (PD) (Italy); Kempley, R. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); and others

    2014-01-21

    γ Rays and neutrons, emitted following spontaneous fission of {sup 252}Cf, were measured in an AGATA experiment performed at INFN Laboratori Nazionali di Legnaro in Italy. The setup consisted of four AGATA triple cluster detectors (12 36-fold segmented high-purity germanium crystals), placed at a distance of 50 cm from the source, and 16 HELENA BaF{sub 2} detectors. The aim of the experiment was to study the interaction of neutrons in the segmented high-purity germanium detectors of AGATA and to investigate the possibility to discriminate neutrons and γ rays with the γ-ray tracking technique. The BaF{sub 2} detectors were used for a time-of-flight measurement, which gave an independent discrimination of neutrons and γ rays and which was used to optimise the γ-ray tracking-based neutron rejection methods. It was found that standard γ-ray tracking, without any additional neutron rejection features, eliminates effectively most of the interaction points due to recoiling Ge nuclei after elastic scattering of neutrons. Standard tracking rejects also a significant amount of the events due to inelastic scattering of neutrons in the germanium crystals. Further enhancements of the neutron rejection was obtained by setting conditions on the following quantities, which were evaluated for each event by the tracking algorithm: energy of the first and second interaction point, difference in the calculated incoming direction of the γ ray, and figure-of-merit value. The experimental results of tracking with neutron rejection agree rather well with GEANT4 simulations.

  12. Current perspectives on antibody-mediated rejection after lung transplantation

    Directory of Open Access Journals (Sweden)

    Witt CA

    2014-10-01

    Full Text Available Chad A Witt, Ramsey R Hachem Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, MO, USA Abstract: The role of donor-specific antibodies (DSA to human leukocyte antigens and the burden of antibody-mediated rejection (AMR in lung transplantation remain enigmatic. Over the past several years, evidence has been emerging that humoral immunity plays an important role in the development of both acute and chronic lung allograft dysfunction (CLAD. Multiple case reports and case series have identified lung allograft recipients with clinical findings consistent with acute AMR. However, there is currently no widely accepted definition for AMR in lung transplantation, and this has been a significant barrier to furthering our understanding of this form of rejection. Nonetheless, the development of DSA after transplantation has consistently been identified as an independent risk factor for persistent and high-grade acute cellular rejection and CLAD. This has raised the possibility that chronic AMR may be a distinct phenotype of CLAD although evidence supporting this paradigm is still lacking. Additionally, antibodies to lung-restricted self-antigens (collagen V and K-α 1 tubulin have been associated with primary graft dysfunction early and the development of CLAD late after transplantation, and emerging evidence underscores significant interactions between autoimmunity and alloimmunity after transplantation. There is currently an active International Society for Heart and Lung Transplantation working group that is developing an operational definition for AMR in lung transplantation. This will be critical to improve our understanding of this form of rejection and conduct clinical trials to identify optimal treatment strategies. This review will summarize the literature on DSA and AMR in lung transplantation and discuss the impact of antibodies to self-antigens on lung

  13. Phytotherapy in medieval Serbian medicine according to the pharmacological manuscripts of the Chilandar Medical Codex (15-16th centuries).

    Science.gov (United States)

    Jarić, Snežana; Mitrović, Miroslava; Djurdjević, Lola; Kostić, Olga; Gajić, Gordana; Pavlović, Dragana; Pavlović, Pavle

    2011-09-01

    The Chilandar Medical Codex is the most significant and best preserved medieval Serbian manuscript and collects together documents on European medical science from the 12th to 15th centuries. It represents the best-known and most complete example of a large collection of medical manuscripts from the Salerno-Montpellier school, written in the vernacular - something which does not exist among the majority of European nations. This paper presents the section of the Codex that deals with phytotherapy, which is contained within the pharmacological manuscripts. An analysis of their contents shows that out of a total of 167 recorded substances, 135 are of plant origin (81%), 13 animal origin (7.7%) and 19 inorganic (11.3%). The recorded plant species are categorised into 63 families, of which the most frequent are: Apiaceae (8.1%), Lamiaceae (8.1%), Asteraceae (5.9%), Rosaceae (5.9%) and Fabaceae (4.4%). All possible plant parts were used in treatments: the whole plant (6%), underground parts (13.7% - root, rhizome, bulb) and aerial parts (80.3% - stem, leaf, flower, buds, fruit, seeds). Of the plants quoted, the following are mentioned most frequently: Vitis sp. (120), Rosa canina (55), Olea europaea (45), Pistacia lentiscus (25), Saccharum officinarum (23), Artemisia absinthium (16) and Foeniculum vulgare (15). The contents of the pharmacological manuscripts of the Chilandar Medical Codex point to the sound contemporary knowledge of the diversity of plant species, their origins, habitat types, the levels of their healing powers, and when and how to gather them and prepare them, as well as the recommended dose for the treatment of specific illnesses. As these manuscripts contain not only common, lay terms for the plants, but also scientific, botanical ones, we can consider them the precursor to Serbian botany. Based on its contents and the way in which they are presented, it can be viewed not only as the first Serbian pharmacopeia, but first Slavic pharmacopeia, too

  14. Plasma cell-rich acute rejection of the renal allograft: A distinctive morphologic form of acute rejection?

    Science.gov (United States)

    Gupta, R; Sharma, A; Mahanta, P J; Agarwal, S K; Dinda, A K

    2012-05-01

    This study was aimed at evaluating the clinicopathologic features of plasma cell-rich acute rejection (PCAR) of renal allograft and comparing them with acute cellular rejection (ACR), non-plasma cell-rich type. During a 2-year period, eight renal allograft biopsies were diagnosed as PCAR (plasma cells >10% of interstitial infiltrate). For comparison, 14 biopsies with ACR were included in the study. Detailed pretransplant data, serum creatinine at presentation, and other clinical features of all these cases were noted. Renal biopsy slides were reviewed and relevant immunohistochemistry performed for characterization of plasma cell infiltrate. The age range and duration of transplantation to diagnosis of acute rejection were comparable in both the groups. Histologically, the proportion of interstitial plasma cells, mean interstitial inflammation, and tubulitis score were higher in the PCAR group compared with cases with ACR. A significant difference was found in the outcome at last follow-up, being worse in patients with PCAR. This study shows that PCAR portends a poor outcome compared with ACR, with comparable Banff grade of rejection. Due to its rarity and recent description, nephrologists and renal pathologists need to be aware of this entity.

  15. The Newton papers the strange and true odyssey of Isaac Newton's manuscripts

    CERN Document Server

    Dry, Sarah

    2014-01-01

    When Isaac Newton died at 85 without a will on March 20, 1727, he left a mass of disorganized papers-upwards of 8 million words-that presented an immediate challenge to his heirs. Most of these writings, on subjects ranging from secret alchemical formulas to impassioned rejections of the Holy Trinity to notes and calculations on his core discoveries in calculus, universal gravitation, and optics, were summarily dismissed by his heirs as "not fit to be printed." Rabidly heretical, alchemically obsessed, and possibly even mad, the Newton presented in these papers threatened to undermine not just his personal reputation but the status of science itself. As a result, the private papers of the world's greatest scientist remained hidden to all but a select few for over two hundred years. In The Newton Papers, Sarah Dry divulges the story of how this secret archive finally came to light-and the complex and contradictory man it revealed. Covering a broad swath of history, Dry explores who controlled Newton's legacy, ...

  16. Are there cases in fifteenth-century Dutch? A ‘case study’ of an Utrecht manuscript (1464)

    DEFF Research Database (Denmark)

    Robbe, Joost Roger

    2016-01-01

    This article examines the case system in a fifteenth-century Utrecht manuscript. It demonstrates that there is a functional case system in the manuscript. However, it also identifies a relatively small number of mistakes – grammatical errors as well as hypercorrections – in how this case system...... is used. It argues that these mistakes indicate that the case system had lost its support in the underlying spoken dialect. The mistakes concern both the use of cases in the nominative and the accusative, and the use of gender markers in the genitive and the dative. By examining the mistakes in the use...... of cases (accusative and nominative), it is possible to determine the conditions for syncretic n-deletion in the underlying spoken dialect; and, by examining the mistakes in the use of gender markers (in the genitive and dative), it is possible to determine the expansion of masculine flexion...

  17. Prototyping an Electronic Edition of William Blake’s Manuscript of Vala, or the Four Zoas: A Progress Report

    Directory of Open Access Journals (Sweden)

    Morris Eaves

    2015-12-01

    Full Text Available This article describes the recent experiments undertaken by the 'William Blake Archive' in preparing a digital edition of 'Vala, or the Four Zoas', one of Blake’s most materially challenging works. The aim is to provide users with multiple tools for analysing Blake’s messy and mysterious manuscript: a high-quality image of the manuscript page paired with a dynamic transcription that allows readers to choose the level of detail they want for understanding what it is, precisely, they are looking at. However, the existing encoding standards and display were revealed to be totally inadequate by the complexity of 'The Four Zoas', and early models were almost impossible to read and understand. The article traces the journey towards the latest prototype as the team try to strike a balance between detail and accessibility, description and interpretation, readability and reliability, and established conventions and new approaches. ' ''

  18. Southeast Asian palm leaf manuscript images: a review of handwritten text line segmentation methods and new challenges

    Science.gov (United States)

    Kesiman, Made Windu Antara; Valy, Dona; Burie, Jean-Christophe; Paulus, Erick; Sunarya, I. Made Gede; Hadi, Setiawan; Sok, Kim Heng; Ogier, Jean-Marc

    2017-01-01

    Due to their specific characteristics, palm leaf manuscripts provide new challenges for text line segmentation tasks in document analysis. We investigated the performance of six text line segmentation methods by conducting comparative experimental studies for the collection of palm leaf manuscript images. The image corpus used in this study comes from the sample images of palm leaf manuscripts of three different Southeast Asian scripts: Balinese script from Bali and Sundanese script from West Java, both from Indonesia, and Khmer script from Cambodia. For the experiments, four text line segmentation methods that work on binary images are tested: the adaptive partial projection line segmentation approach, the A* path planning approach, the shredding method, and our proposed energy function for shredding method. Two other methods that can be directly applied on grayscale images are also investigated: the adaptive local connectivity map method and the seam carving-based method. The evaluation criteria and tool provided by ICDAR2013 Handwriting Segmentation Contest were used in this experiment.

  19. Application of Native Speaker Models for Identifying Deviations in Rhetorical Moves in Non-Native Speaker Manuscripts

    Directory of Open Access Journals (Sweden)

    Assef Khalili

    2016-06-01

    Full Text Available Introduction: Explicit teaching of generic conventions of a text genre, usually extracted from native-speaker (NS manuscripts, has long been emphasized in the teaching of Academic Writing inEnglish for Specific Purposes (henceforthESP classes, both in theory and practice. While consciousness-raising about rhetorical structure can be instrumental to non-native speakers(NNS, it has to be admitted that most works done in the field of ESP have tended to focus almost exclusively on native-speaker (NS productions, giving scant attention to non-native speaker (NNS manuscripts. That is, having outlined established norms for good writing on the basis of NS productions, few have been inclined to provide a descriptive account of NNS attempts at trying to produce a research article (RA in English. That is what we have tried to do in the present research. Methods: We randomly selected 20 RAs in dentistry and used two well-established models for results and discussion sections to try to describe the move structure of these articles and show the points of divergence from the established norms. Results: The results pointed to significant divergences that could seriously compromise the quality of an RA. Conclusion: It is believed that the insights gained on the deviations in NNS manuscripts could prove very useful in designing syllabi for ESP classes.

  20. A little known astronomer in the late Islamic period. A study of Qasim ali al-Qayini's manuscripts

    CERN Document Server

    Akbari, Marjan

    2012-01-01

    It is widely believed that the advance of science in the Islamic world after the mid-fifteenth century A.D. suffered a decline. For the purpose of examining this belief, a manuscript by Qasim ali al-Qayini (ca. A.D.1685) was chosen based on previous works which considered it a valuable source on the history of optics that had not been studied before. After studying his major optical manuscript, titled Manazir wa Maraya, it was found very interesting that the majority of al-Qayini's propositions relating to natural phenomena were not merely geometrical definitions, but that the proofs related to astronomy. As an example, in one case, which had not been explained in previous astronomical and optical manuscripts, al-Qayini tried, despite lacking a vigorous proof, to show how a special point in a room could be lit up by sunlight throughout the year. His particular interest in astronomy led us to a general study of his other works, and it is worth noting that out of the nineteen works that have been attributed to ...

  1. ST2 IN REJECTION OF THE TRANSPLANTED HEART

    Directory of Open Access Journals (Sweden)

    O. P. Shevchenko

    2015-01-01

    Full Text Available This review summarizes the current literature devoted to the analysis of prognostic role of ST2 biomarker in rejection of the transplanted heart. ST2 is one of the most promising diagnostic markers of the development and severity of heart failure as well as the mortality risk in patients with cardiovascular diseases. ST2 is expressed in cardiomyocytes in response to a variety of pathological processes and mechanical damage to the heart, which allows diagnosing cardiovascular diseases before clinical manifestations. Presumably, measuring the level of ST2 in heart transplant may have diagnostic and prognostic value in the assessment of graft and risk of rejection. Currently, accumulated clinical data on the role of given biomarker in heart transplantation are not enough, and further research on the relation of ST2 levels with different clinical and laboratory parameters in heart recipients is necessary. 

  2. Recurrence and rejection in liver transplantation for primary sclerosing cholangitis

    Institute of Scientific and Technical Information of China (English)

    Bjarte Fosby; Tom H Karlsen; Espen Melum

    2012-01-01

    Primary sclerosing cholangitis (PSC) is a chronic progressive inflammatory disease affecting the bile ducts, leading to fibrosis and eventually cirrhosis in most patients. Its etiology is unknown and so far no effective medical therapy is available. Liver transplantation (LTX) is the only curative treatment and at present PSC is the main indication for LTX in the Scandinavian countries. Close to half of the PSC patients experience one or more episodes of acute cellular rejection (ACR) following transplantation and approximately 1/5 of the transplanted patients develop recurrent disease in the graft. In addition, some reports indicate that ACR early after LTX for PSC can influence the risk for recurrent disease. For these important post-transplantation entities affecting PSC patients, we have reviewed the current literature on epidemiology, pathogenesis, treatment and the possible influence of rejection on the risk of recurrent disease in the allograft.

  3. Modified active disturbance rejection control for time-delay systems.

    Science.gov (United States)

    Zhao, Shen; Gao, Zhiqiang

    2014-07-01

    Industrial processes are typically nonlinear, time-varying and uncertain, to which active disturbance rejection control (ADRC) has been shown to be an effective solution. The control design becomes even more challenging in the presence of time delay. In this paper, a novel modification of ADRC is proposed so that good disturbance rejection is achieved while maintaining system stability. The proposed design is shown to be more effective than the standard ADRC design for time-delay systems and is also a unified solution for stable, critical stable and unstable systems with time delay. Simulation and test results show the effectiveness and practicality of the proposed design. Linear matrix inequality (LMI) based stability analysis is provided as well.

  4. Active disturbance rejection in large flexible space structures

    Science.gov (United States)

    Parlos, Alexander G.; Sunkel, John W.

    1990-01-01

    The design of an active control law for the rejection of persistent disturbances, in large space structures is presented. The control system design approach is based on a deterministic model of the disturbances and it optimizes the magnitude of the disturbance that the structure can tolerate without violating certain predetermined constraints. In addition to closed-loop stability, the explicit treatment of state, control, and control rate constraints, such as structural displacement and control actuator effort, guarantees that the final design will exhibit desired performance characteristics. The technique is applied to a simple two-bay truss structure, and its response is compared with that obtained using a linear-quadratic-Gaussian/loop-transfer-recovery (LQG/LTR) compensator. Preliminary results indicate that the proposed control system can reject persistent disturbances of greater magnitude by utilizing most of the available control, while limiting the structural displacements to within desired tolerances.

  5. Composite disturbance rejection control based on generalized extended state observer.

    Science.gov (United States)

    Zhang, Yanjun; Zhang, Jun; Wang, Lu; Su, Jianbo

    2016-07-01

    Traditional extended state observer (ESO) design method does not focus on analysis of system reconstruction strategy. The prior information of the controlled system cannot be used for ESO implementation to improve the control accuracy. In this paper, composite disturbance rejection control strategy is proposed based on generalized ESO. First, the disturbance rejection performance of traditional ESO is analyzed to show the essence of the reconstruction strategy. Then, the system is reconstructed based on the equivalent disturbance model. The generalized ESO is proposed based on the reconstructed model, while convergence of the proposed ESO is analyzed along with the outer loop feedback controller. Simulation results on a second order mechanical system show that the proposed generalized ESO can deal with the external disturbance with known model successfully. Experiment of attitude tracking task on an aircraft is also carried out to show the effectiveness of the proposed method. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  6. Control of Spacecraft Formation with Disturbance Rejection and Exponential Gains

    Directory of Open Access Journals (Sweden)

    R. Schlanbusch

    2013-01-01

    Full Text Available We address the problem of state feedback translational motion control of a spacecraft formation through a modified sliding surface controller using variable gains and I^2 action for disturbance rejection. The exponential varying gains ensure faster convergence of the state trajectories during attitude maneuver while keeping the gains small (and the system less stiff for station keeping. Integral action is introduced for rejection of disturbances with a constant nonzero mean such as aerodynamic drag. A direct consequence is a drop in energy consumption when affected by sensor noise and a decrease in size of the error states residual when operating close to the equilibrium point. A large number of simulation results are presented to show the control performance.

  7. Background rejection in NEXT using deep neural networks

    CERN Document Server

    Renner, J.

    2017-01-01

    We investigate the potential of using deep learning techniques to reject background events in searches for neutrinoless double beta decay with high pressure xenon time projection chambers capable of detailed track reconstruction. The differences in the topological signatures of background and signal events can be learned by deep neural networks via training over many thousands of events. These networks can then be used to classify further events as signal or background, providing an additional background rejection factor at an acceptable loss of efficiency. The networks trained in this study performed better than previous methods developed based on the use of the same topological signatures by a factor of 1.2 to 1.6, and there is potential for further improvement.

  8. Performance Evaluation of Air-Based Heat Rejection Systems

    Directory of Open Access Journals (Sweden)

    Hannes Fugmann

    2015-01-01

    Full Text Available On the basis of the Number of Transfer Units (NTU method a functional relation between electric power for fans/pumps and effectiveness in dry coolers and wet cooling towers is developed. Based on this relation, a graphical presentation method of monitoring and simulation data of heat rejection units is introduced. The functional relation allows evaluating the thermodynamic performance of differently sized heat rejection units and comparing performance among them. The method is used to evaluate monitoring data of dry coolers of different solar cooling field projects. The novelty of this approach is that performance rating is not limited by a design point or standardized operating conditions of the heat exchanger, but is realizable under flexible conditions.

  9. Self-excitation in Francis runner during load rejection

    Science.gov (United States)

    Moisan, É.; Giacobbi, D.-B.; Gagnon, M.; Léonard, F.

    2014-03-01

    Typically, transients such as load rejection generate only a few high vibration cycles in Francis runners. However, in the cases presented in this study, a sustained vibration around a natural frequency was observed on three (3) homologous Francis runners of different sizes during such events. The first two (2) runners were equipped with strain gauges on the blades and displacement sensors positioned circumferentially in the bottom ring and head cover around the runner labyrinth seals. The third runner was monitored only with displacement sensors on non-rotating components. The data from the first two (2) runners provided a better understanding of the parameters influencing the appearance of the high amplitude vibrations and allowed the implementation of a test plan to circumvent the phenomenon during commissioning of the third runner. Based on the measured data, the distributor's closing parameters were optimized to eliminate the vibration observed during load rejection on most of the operating range and reduce it significantly at full load.

  10. Heat pipe radiator. [for spacecraft waste heat rejection

    Science.gov (United States)

    Swerdling, B.; Alario, J.

    1973-01-01

    A 15,000 watt spacecraft waste heat rejection system utilizing heat pipe radiator panels was investigated. Of the several concepts initially identified, a series system was selected for more in-depth analysis. As a demonstration of system feasibility, a nominal 500 watt radiator panel was designed, built and tested. The panel, which is a module of the 15,000 watt system, consists of a variable conductance heat pipe (VCHP) header, and six isothermalizer heat pipes attached to a radiating fin. The thermal load to the VCHP is supplied by a Freon-21 liquid loop via an integral heat exchanger. Descriptions of the results of the system studies and details of the radiator design are included along with the test results for both the heat pipe components and the assembled radiator panel. These results support the feasibility of using heat pipes in a spacecraft waste heat rejection system.

  11. Background rejection in NEXT using deep neural networks

    CERN Document Server

    Renner, J; Vidal, J Muñoz; Benlloch-Rodríguez, J M; Botas, A; Ferrario, P; Gómez-Cadenas, J J; Álvarez, V; Azevedo, C D R; Borges, F I G; Cárcel, S; Carrión, J V; Cebrián, S; Cervera, A; Conde, C A N; Díaz, J; Diesburg, M; Esteve, R; Fernandes, L M P; Ferreira, A L; Freitas, E D C; Goldschmidt, A; González-Díaz, D; Gutiérrez, R M; Hauptman, J; Henriques, C A O; Morata, J A Hernando; Herrero, V; Jones, B; Labarga, L; Laing, A; Lebrun, P; Liubarsky, I; López-March, N; Lorca, D; Losada, M; Martín-Albo, J; Martínez-Lema, G; Martínez, A; Monrabal, F; Monteiro, C M B; Mora, F J; Moutinho, L M; Nebot-Guinot, M; Novella, P; Nygren, D; Para, A; Pérez, J; Querol, M; Ripoll, L; Rodríguez, J; Santos, F P; Santos, J M F dos; Serra, L; Shuman, D; Simón, A; Sofka, C; Sorel, M; Toledo, J F; Torrent, J; Tsamalaidze, Z; Veloso, J F C A; White, J; Webb, R; Yahlali, N; Yepes-Ramírez, H

    2016-01-01

    We investigate the potential of using deep learning techniques to reject background events in searches for neutrinoless double beta decay with high pressure xenon time projection chambers capable of detailed track reconstruction. The differences in the topological signatures of background and signal events can be learned by deep neural networks via training over many thousands of events. These networks can then be used to classify further events as signal or background, providing an additional background rejection factor at an acceptable loss of efficiency. The networks trained in this study performed 15-60% better than previous methods developed based on the use of the same topological signatures, and there is potential for further improvement.

  12. Perturbations in the Urinary Exosome in Transplant Rejection

    Energy Technology Data Exchange (ETDEWEB)

    Sigdel, Tara K.; NG, Yolanda; Lee, Sangho; Nicora, Carrie D.; Qian, Weijun; Smith, Richard D.; Camp, David G.; Sarwal, Minnie M.

    2015-01-05

    Background: Urine exosomes, vesicles exocytosed into urine by all renal epithelial cell types, occur under normal physiologic and disease states. Exosome contents may mirror disease-specific proteome perturbations in kidney injury. Analysis methodologies for the exosomal fraction of the urinary proteome were developed and for comparing the urinary exosomal fraction versus unfractionated proteome for biomarker discovery. Methods: Urine exosomes were isolated by centrifugal filtration from mid-stream, second morning void, urine samples collected from kidney transplant recipients with and without biopsy matched acute rejection. The proteomes of unfractionated whole urine (Uw) and urine exosomes (Uexo) underwent mass spectrometry-based quantitative proteomics analysis. The proteome data were analyzed for significant differential protein abundances in acute rejection (AR). Results: Identifications of 1018 and 349 proteins, Uw and Uexo fractions, respectively, demonstrated a 279 protein overlap between the two urinary compartments with 25%(70) of overlapping proteins unique to Uexoand represented membrane bound proteins (p=9.31e-7). Of 349 urine exosomal proteins identified in transplant patients 220 were not previously identified in the normal urine exosomal fraction. Uexo proteins (11), functioning in the inflammatory / stress response, were more abundant in patients with biopsy-confirmed acute rejection, 3 of which were exclusive to Uexo. Uexo AR-specific biomarkers (8) were also detected in Uw, but since they were observed at significantly lower abundances in Uw, they were not significant for AR in Uw. Conclusions: A rapid urinary exosome isolation method and quantitative measurement of enriched Uexo proteins was applied. Urine proteins specific to the exosomal fraction were detected either in unfractionated urine (at low abundances) or by Uexo fraction analysis. Perturbed proteins in the exosomal compartment of urine collected from kidney transplant patients were

  13. Disturbance Rejection for Fractional-Order Time-Delay Systems

    OpenAIRE

    Hai-Peng Jiang; Yong-Qiang Liu

    2016-01-01

    This paper presents an equivalent-input-disturbance (EID-) based disturbance rejection method for fractional-order time-delay systems. First, a modified state observer is applied to reconstruct the state of the fractional-order time-delay plant. Then, a disturbance estimator is designed to actively compensate for the disturbances. Under such a construction of the system, by constructing a novel monochromatic Lyapunov function and using direct Lyapunov approach, the stability analysis and cont...

  14. Reverse osmosis membrane of high urea rejection properties. [water purification

    Science.gov (United States)

    Johnson, C. C.; Wydeven, T. J. (Inventor)

    1980-01-01

    Polymeric membranes suitable for use in reverse osmosis water purification because of their high urea and salt rejection properties are prepared by generating a plasma of an unsaturated hydrocarbon monomer and nitrogen gas from an electrical source. A polymeric membrane is formed by depositing a polymer of the unsaturated monomer from the plasma onto a substrate, so that nitrogen from the nitrogen gas is incorporated within the polymer in a chemically combined form.

  15. Daclizumab prevents acute renal allograft rejection: 1 year analysis

    Institute of Scientific and Technical Information of China (English)

    Xiaoming Pan; Wujun Xue; Puxun Tian; Xiaoming Ding

    2007-01-01

    Objective :To investigate the clinical effect of Daclizumab on preventing acute rejection in renal transplant recipients.Methods:71 patients were randomly divided into two groups:Daclizumab group (n =26) and control group (n = 45). Baseline regimen of mycophenolate mofetil (MMF), cyclosporin (CsA), methylprednisolone (MPD) and prednisone (Pred) were administered to all patients. The treatment of Daclizumab was based on baseline regimen. The Daclizumab group received Daclizumab twice before and after renal transplant. The occurrence of post-transplantation acute rejection, renal function and T lymphocyte subtypes were sequentially monitored; meanwhile adverse events, infection episode, and patient and graft survival were observed.All of patients received a follow-up of 12 months at least. Results :The occurrence of acute rejection in Daclizumab group in 1,3, 6 and 12 months after renal transplantation was 7.7%, 19.2%, 23.1% and 30.8%, respectively,while it was 15.6% ,28.9%,35.6% and 46.7% in the control group. There was significant difference between the two group(P < 0.05). There was no difference in infection episodes and adverse events between the Daclizumab group and control group. One year patient survival was 92.3% in Daclizumab group, 91.1% in control group (P > 0.05), compared with graft survival of 96.2 % and 93.3 % for Daclizumab and control group, respectively (P > 0. 05). The renal function in Daclizumab group in 1, 6 and 12 months after renal transplantation was better than that in control group (P < 0.05). The CD3+ and CD4+ subtypes decreased in both two groups after operation but no significant difference (P > 0.05). Conclusion:Daclizumab combined with MMF, CsA, MPD and Pred therapeutic regimen was effective to reduce the occurrence of acute rejection in renal transplant recipients and have no influence on T lymphocyte subtypes.

  16. Performance Comparison of Thin and Thick Film Microstrip Rejection Filters

    OpenAIRE

    Mandhare, M. M.; S.A. Gangal; M. S. Setty; Karekar, R. N.

    1988-01-01

    A performance comparison of microstripline circuits using thin and thick film techniques has been studied, in which a Microstrip rejection filter, in the X-band of microwaves, is used as test circuit. A thick film technique is capable of giving good adhesive films with comparable d.c. sheet resistivity, but other parameters such as open area (porosity), particle size, and edge definition are inferior to thin-film microstrip filters. Despite this drawback, the average value of transmission, tr...

  17. Domestic violence and rejection of LGBT children in Serbia

    OpenAIRE

    Mršević, Zorica

    2015-01-01

    The paper provides analysis of different forms of violence against LGBT children within the regime of so-called forced normalization (Butler) committed by their parents and other close relatives. These regimes are often rigid normative type, much less of the flexible type of normalizing. The term 'production of the body' in the case of domestic violence against LGBT chil­dren comprises rejection, threats, forced medical treatment, various forms of physical and psychological violence and eject...

  18. Inferring Acceptance and Rejection in Dialogue by Default Rules of Inference

    CERN Document Server

    Walker, M A

    1996-01-01

    This paper discusses the processes by which conversants in a dialogue can infer whether their assertions and proposals have been accepted or rejected by their conversational partners. It expands on previous work by showing that logical consistency is a necessary indicator of acceptance, but that it is not sufficient, and that logical inconsistency is sufficient as an indicator of rejection, but it is not necessary. I show how conversants can use information structure and prosody as well as logical reasoning in distinguishing between acceptances and logically consistent rejections, and relate this work to previous work on implicature and default reasoning by introducing three new classes of rejection: {\\sc implicature rejections}, {\\sc epistemic rejections} and {\\sc deliberation rejections}. I show how these rejections are inferred as a result of default inferences, which, by other analyses, would have been blocked by the context. In order to account for these facts, I propose a model of the common ground that...

  19. Rejection of trace organic compounds by high-pressure membranes.

    Science.gov (United States)

    Kim, T U; Amy, G; Drewes, J E

    2005-01-01

    High-pressure membranes, encompassing reverse osmosis (RO), nanofiltration (NF), and low-pressure RO, may provide an effective treatment barrier for trace organic compounds including disinfection by-products (DBPs), pesticides, solvents, endocrine disrupting compounds (EDCs) and pharmaceutically active compounds (PhACs). The objective is to develop a mechanistic understanding of the rejection of trace organic compounds by high-pressure membranes, based on an integrated framework of compound properties, membrane properties, and operational conditions. Eight trace organic compounds, four DBPs and four chlorinated (halogenated) solvents, are being emphasized during an initial study, based on considerations of compound properties, occurrence, and health effects (regulations). Four polyamide FilmTec membranes; three reverse osmosis/RO (BW-400, LE-440, XLE-440) and one nanofiltration/NF (NF-90); are being characterized according to pure water permeability (PWP), molecular weight cutoff (MWCO), hydrophobicity (contact angle), and surface charge (zeta potential). It is noteworthy that rejections of compounds of intermediate hydrophobicity by the candidate membranes were observed to be less than salt rejections reported for these membranes, suggesting that transport of these solutes through these membranes is facilitated by solute-membrane interactions. We are continuing with diffusion cell measurements to describe solute-membrane interactions by estimation of diffusion coefficients through membranes pores, either hindered or facilitated.

  20. Exploiting Reject Option in Classification for Social Discrimination Control

    KAUST Repository

    Kamiran, Faisal

    2017-09-29

    Social discrimination is said to occur when an unfavorable decision for an individual is influenced by her membership to certain protected groups such as females and minority ethnic groups. Such discriminatory decisions often exist in historical data. Despite recent works in discrimination-aware data mining, there remains the need for robust, yet easily usable, methods for discrimination control. In this paper, we utilize reject option in classification, a general decision theoretic framework for handling instances whose labels are uncertain, for modeling and controlling discriminatory decisions. Specifically, this framework permits a formal treatment of the intuition that instances close to the decision boundary are more likely to be discriminated in a dataset. Based on this framework, we present three different solutions for discrimination-aware classification. The first solution invokes probabilistic rejection in single or multiple probabilistic classifiers while the second solution relies upon ensemble rejection in classifier ensembles. The third solution integrates one of the first two solutions with situation testing which is a procedure commonly used in the court of law. All solutions are easy to use and provide strong justifications for the decisions. We evaluate our solutions extensively on four real-world datasets and compare their performances with previously proposed discrimination-aware classifiers. The results demonstrate the superiority of our solutions in terms of both performance and flexibility of applicability. In particular, our solutions are effective at removing illegal discrimination from the predictions.

  1. Dynamic positioning system based on active disturbance rejection technology

    Science.gov (United States)

    Lei, Zhengling; Guo, Chen; Fan, Yunsheng

    2015-08-01

    A dynamically positioned vessel, by the International Maritime Organization (IMO) and the certifying class societies (DNV, ABS, LR, etc.), is defined as a vessel that maintains its position and heading (fixed location or pre-determined track) exclusively by means of active thrusters. The development of control technology promotes the upgrading of dynamic positioning (DP) systems. Today there are two different DP systems solutions available on the market: DP system based on PID regulator and that based on model-based control. Both systems have limited disturbance rejection capability due to their design principle. In this paper, a new DP system solution is proposed based on Active Disturbance Rejection Control (ADRC) technology. This technology is composed of Tracking-Differentiator (TD), Extended State Observer (ESO) and Nonlinear Feedback Combination. On one hand, both TD and ESO can act as filters and can be used in place of conventional filters; on the other hand, the total disturbance of the system can be estimated and compensated by ESO, which therefore enhances the system's disturbance rejection capability. This technology's advantages over other methods lie in two aspects: 1) This method itself can not only achieve control objectives but also filter noisy measurements without other specialized filters; 2) This method offers a new useful approach to suppress the ocean disturbance. The simulation results demonstrate the effectiveness of the proposed method.

  2. Adaptive clutter rejection for ultrasound color Doppler imaging

    Science.gov (United States)

    Yoo, Yang Mo; Managuli, Ravi; Kim, Yongmin

    2005-04-01

    We have developed a new adaptive clutter rejection technique where an optimum clutter filter is dynamically selected according to the varying clutter characteristics in ultrasound color Doppler imaging. The selection criteria have been established based on the underlying clutter characteristics (i.e., the maximum instantaneous clutter velocity and the clutter power) and the properties of various candidate clutter filters (e.g., projection-initialized infinite impulse response and polynomial regression). We obtained an average improvement of 3.97 dB and 3.27 dB in flow signal-to-clutter-ratio (SCR) compared to the conventional and down-mixing methods, respectively. These preliminary results indicate that the proposed adaptive clutter rejection method could improve the sensitivity and accuracy in flow velocity estimation for ultrasound color Doppler imaging. For a 192 x 256 color Doppler image with an ensemble size of 10, the proposed method takes only 57.2 ms, which is less than the acquisition time. Thus, the proposed method could be implemented in modern ultrasound systems, while providing improved clutter rejection and more accurate velocity estimation in real time.

  3. Optical axis jitter rejection for double overlapped adaptive optics systems

    Science.gov (United States)

    Luo, Qi; Luo, Xi; Li, Xinyang

    2016-04-01

    Optical axis jitters, or vibrations, which arise from wind shaking and structural oscillations of optical platforms, etc., cause a deleterious impact on the performance of adaptive optics systems. When conventional integrators are utilized to reject such high frequency and narrow-band disturbance, the benefits are quite small despite their acceptable capabilities to reject atmospheric turbulence. In our case, two suits of complete adaptive optics systems called double overlapped adaptive optics systems (DOAOS) are used to counteract both optical jitters and atmospheric turbulence. A novel algorithm aiming to remove vibrations is proposed by resorting to combine the Smith predictor and notch filer. With the help of loop shaping method, the algorithm will lead to an effective and stable controller, which makes the characteristics of error transfer function close to notch filters. On the basis of the spectral analysis of observed data, the peak frequency and bandwidth of vibrations can be identified in advance. Afterwards, the number of notch filters and their parameters will be determined using coordination descending method. The relationship between controller parameters and filtering features is discussed, and the robustness of the controller against varying parameters of the control object is investigated. Preliminary experiments are carried out to validate the proposed algorithms. The overall control performance of DOAOS is simulated. Results show that time delays are a limit of the performance, but the algorithm can be successfully implemented on our systems, which indicate that it has a great potential to reject jitters.

  4. Late-onset acute rejection after living donor liver transplantation

    Institute of Scientific and Technical Information of China (English)

    Nobuhisa Akamatsu; Yasuhiko Sugawara; Sumihito Tamura; Junichi Keneko; Yuichi Matsui; Kiyoshi Hasegawa; Masatoshi Makuuchi

    2006-01-01

    AIM: To investigate the incidence and risk factors of late-onset acute rejection (LAR) and to clarify the effectiveness of our immunosuppressive regime consisting of life-long administration of tacrolimus and steroids.METHODS: Adult living donor liver transplantation recipients (n = 204) who survived more than 6 mo after living donor liver transplantation were enrolled.Immunosuppression was achieved using tacrolimus and methylprednisolone. When adverse effects of tacrolimus were detected, the patient was switched to cyclosporine. Six months after transplantation,tacrolimus or cyclosporine was carefully maintained at a therapeutic level. The methylprednisolone dosage was maintained at 0.05 mg/kg per day by oral administration.Acute rejections that occurred more than 6 mo after the operation were defined as late-onset. The median followup period was 34 mo.RESULTS: LAR was observed in 15 cases (7%) and no chronic rejection was observed. The incidence of hyperlipidemia, chronic renal failure, new-onset posttransplantation diabetes, and deep fungal infection were 13%, 2%, 24%, and 17%, respectively. Conversion from tacrolimus to cyclosporine was required in 38 patients (19%). Multivariate analysis revealed that a cyclosporinebased regimen was significantly associated with LAR.CONCLUSION: Both LAR and drug-induced adverse events happen at a low incidence, supporting the safety and efficacy of the present immunosuppression regimen for living donor liver transplantation.

  5. Language Skills, Peer Rejection, and the Development of Externalizing Behavior from Kindergarten to Fourth Grade

    Science.gov (United States)

    Menting, Barbara; Van Lier, Pol A. C.; Koot, Hans M.

    2011-01-01

    Background: Children with poorer language skills are more likely to show externalizing behavior problems, as well as to become rejected by their peers. Peer rejection has also been found to affect the development of externalizing behavior. This study explored the role of peer rejection in the link between language skills and the development of…

  6. Language Skills, Peer Rejection, and the Development of Externalizing Behavior from Kindergarten to Fourth Grade

    Science.gov (United States)

    Menting, Barbara; Van Lier, Pol A. C.; Koot, Hans M.

    2011-01-01

    Background: Children with poorer language skills are more likely to show externalizing behavior problems, as well as to become rejected by their peers. Peer rejection has also been found to affect the development of externalizing behavior. This study explored the role of peer rejection in the link between language skills and the development of…

  7. 42 CFR 424.525 - Rejection of a provider or supplier's enrollment application for Medicare enrollment.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Rejection of a provider or supplier's enrollment... provider or supplier's enrollment application for Medicare enrollment. (a) Reasons for rejection. CMS may reject a provider or supplier's enrollment application for the following reasons: (1) The...

  8. Personal and appearance-based rejection sensitivity in body dysmorphic disorder.

    Science.gov (United States)

    Kelly, Megan M; Didie, Elizabeth R; Phillips, Katharine A

    2014-06-01

    Although rejection sensitivity may be an important feature of body dysmorphic disorder (BDD), no studies have examined rejection sensitivity in a clinical sample and compared types of rejection sensitivity in individuals with BDD. Personal and appearance-based rejection sensitivity scores in forty-six patients diagnosed with BDD were compared with published norms. Associations between rejection sensitivity, BDD severity, and other clinical variables were examined. Personal and appearance-based rejection sensitivity scores were 0.6 and 1.1 standard deviation units above published norms, respectively. Greater personal rejection sensitivity was associated with more severe BDD and depressive symptoms, poorer mental health, general health, and physical and social functioning. Greater appearance-based rejection sensitivity was associated with more severe BDD and depressive symptoms, and poorer general health. Appearance-based rejection sensitivity contributed more unique variance to BDD severity than personal rejection sensitivity did; however, personal rejection sensitivity contributed more unique variance to general health than appearance-based rejection sensitivity did.

  9. Could a factor that does not affect egg recognition influence the decision of rejection?

    NARCIS (Netherlands)

    Ruiz-Raya, Francisco; Soler, Manuel; Sanchez-Perez, Lucia L. I.; Ibanez-Alamo, Juan Diego

    2015-01-01

    Rejection of the parasitic egg is the most important defence of hosts against brood parasites. However, this response is variable among and within species, and egg discrimination is not always followed by egg rejection. Low risk of parasitism and high risk of rejection costs may lead to the

  10. Vicarious Group-Based Rejection : Creating a Potentially Dangerous Mix of Humiliation, Powerlessness, and Anger

    NARCIS (Netherlands)

    Veldhuis, Tinka M.; Gordijn, Ernestine H.; Veenstra, Rene; Lindenberg, Siegwart

    2014-01-01

    Rejection can convey that one is seen as inferior and not worth bothering with. Is it possible for people to feel vicariously rejected in this sense and have reactions that are similar to those following personal rejection, such as feeling humiliated, powerless, and angry? A study on personal

  11. Rejection Sensitivity and College Student Depression: Findings and Implications for Counseling

    Science.gov (United States)

    Mellin, Elizabeth A.

    2008-01-01

    This study examined whether rejection sensitivity, or the fear of interpersonal rejection, was related to depression among college students. The regression model that resulted from the study indicated that level of rejection sensitivity accounted for approximately 11% of variance in depression among students in the research. Implications for…

  12. Could a factor that does not affect egg recognition influence the decision of rejection?

    NARCIS (Netherlands)

    Ruiz-Raya, Francisco; Soler, Manuel; Sanchez-Perez, Lucia L. I.; Ibanez-Alamo, Juan Diego

    2015-01-01

    Rejection of the parasitic egg is the most important defence of hosts against brood parasites. However, this response is variable among and within species, and egg discrimination is not always followed by egg rejection. Low risk of parasitism and high risk of rejection costs may lead to the acceptan

  13. 41 CFR 102-38.210 - What happens when bids have been rejected?

    Science.gov (United States)

    2010-07-01

    ... have been rejected? 102-38.210 Section 102-38.210 Public Contracts and Property Management Federal... OF PERSONAL PROPERTY Bids Acceptance of Bids § 102-38.210 What happens when bids have been rejected? You may re-offer items for which all bids have been rejected at the same sale, if possible, or...

  14. ‘Communicating Manuscripts’: Third Conference of LIBER's Manuscript Librarians Group, Berlin, 28-30 November 2007

    Directory of Open Access Journals (Sweden)

    Jutta Weber

    2008-03-01

    Full Text Available LIBER's Manuscript Librarians Group held its third conference, entitled 'Communicating Manuscripts' in Berlin from 28-30 November 2007. More than 70 participants from all over Europe came to discuss their experiences and opinions concerning manuscripts (ranging from medieval codices to modern papers and letter collections — in response to a series of papers delivered by a number of specialists from European research libraries and archival institutions. For the Staatsbibliothek it was a pleasure to welcome them and to make the days in Berlin comfortable and successful.

  15. Acute mixed cellular and humoral rejection of renal allograft with leucopenia.

    Science.gov (United States)

    Agarwal, D K; Hota, J K; Malhotra, V

    2011-08-01

    Diagnosis and management of acute renal allograft dysfunction often pose challenge to nephrologists during practice. Acute rejection is a major cause of acute graft dysfunction but is rare in patients with leucopenia. Acute rejection can have either humoral or cellular components or sometimes mixed components. Mixed acute cellular and humoral rejection often present as steroid resistant rejection. Here we report a patient with live related renal transplant recipient with acute graft dysfunction with leucopenia who was found to have mixed acute cellular and humoral rejection.

  16. Useful Brazilian plants listed in the manuscripts and publications of the Scottish medic and naturalist George Gardner (1812-1849).

    Science.gov (United States)

    Fagg, Christopher W; Lughadha, Eimear Nic; Milliken, William; Nicholas Hind, D J; Brandão, Maria G L

    2015-02-23

    Information regarding the beneficial use of native Brazilian plants was compiled by a number of European naturalists in the 19th century. The Scottish surgeon botanist George Gardner (1812-1849) was one such naturalist; however, the useful plants recorded in his manuscripts have not yet been studied in depth. To present data recorded by Gardner in his manuscript Catalogue of Brazilian Plants regarding the use of native plants by Brazilian people and evaluate the extent to which they have been explored. Data on useful plants were obtained from Gardner׳s manuscript Catalogue of Brazilian Plants deposited in the Archives of the Royal Botanic Gardens, Kew, UK. The identification of each plant was determined and/or updated by consulting the preserved botanical collections of Gardner deposited in the Herbarium of the Royal Botanic Gardens, Kew (hereafter K), and expert determinations in other herbaria where duplicates are held. Correlated pharmacological studies for each plant were obtained from the PubMed database. Information recorded in Gardner׳s diary and previously published elsewhere complemented these data. A total of 63 useful plants was recorded from the Catalogue and a further 30 from Gardner׳s book Travels in the Interior of Brazil (Gardner, 1846). Of the recorded names in the Catalogue, 46 (73%) could be identified to species by consulting specimens collected by Gardner and held at Kew. Thirty-six different traditional uses were registered for the identified plants, the most common being as febrifuges, to treat venereal complaints and as purgatives. Fewer than 50% of these species have been the focus of published pharmacological studies, yet for those which have been thus investigated, the efficacies reported by Gardner were confirmed. The data recorded by Gardner represent a rich, relatively unexplored source of information regarding the traditional uses of Brazilian plants which merits further investigation. Copyright © 2014 Elsevier Ireland Ltd. All

  17. “Secret Language” in Oral and Graphic Form: Religious-Magic Discourse in Aztec Speeches and Manuscripts

    Directory of Open Access Journals (Sweden)

    Katarzyna Mikulska Dąbrowska

    2010-10-01

    Full Text Available The purpose of this paper is to analyze a particular linguistic register of the Nahua (Aztec people that has been classified as “magical-religious” because it was used for communication with the sacred realm. A hypothesis is developed that in the Mesoamerican pictographic calendar-religious manuscripts, which treat matters strictly linked to the supernatural world, a similar register should be evident. Far from considering the information presented in these resources as resulting from the direct transcription of oral language, the idea is that the graphic form represents elements emblematic of orality, although adapted to this particular context and mode for expression.

  18. Spanish Mystic Women of the Golden Century within the Ottoman Empire: Seven Arabic Manuscripts Found in Aleppo (Syria)

    OpenAIRE

    2015-01-01

    This work reports on the existence of seven manuscripts conserved in three different collections of Aleppo (Syria): the Greek-Catholic/Melkite, the Georges and Mathilde Salem Foundation and the Maronite libraries. These seven co­pies contain the Arabic translations of some mystical works written by two mystic women of the Spanish Golden Century, Teresa de Ávila and María de Ágreda. The history of these Arabic versions, translated right in the heart of the Ottoman Arabic provinces, constitutes...

  19. Data for manuscript titled "Historical trends in PM2.5 related premature mortality during 1990-2010 across the northern hemisphere"

    Data.gov (United States)

    U.S. Environmental Protection Agency — This manuscript has 6 figures: Figure 1 shows the modeling domain and includes a map with the different analysis sub-regions. Shapefiles to be used with ArcGIS for...

  20. EPA Contribution to Manuscript "Evaluation and Error Apportionment of an Ensemble of Atmospheric Chemistry Transport Modelling Systems: Multi-variable Temporal and Spatial Breakdown"

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains the data contributed by EPA/ORD/NERL/CED researchers to the manuscript "Evaluation and Error Apportionment of an Ensemble of Atmospheric...

  1. Data used in the analysis presented in the manuscript "Dynamic Evaluation of Two Decades of WRF-CMAQ Ozone Simulations over the Contiguous United States"

    Data.gov (United States)

    U.S. Environmental Protection Agency — Files containing daily maximum 8-hr ozone mixing ratio observations and WRF/CMAQ simulations used in the analysis presented in the manuscript “Dynamic Evaluation of...

  2. PD1-Expressing T Cell Subsets Modify the Rejection Risk in Renal Transplant Patients

    Science.gov (United States)

    Pike, Rebecca; Thomas, Niclas; Workman, Sarita; Ambrose, Lyn; Guzman, David; Sivakumaran, Shivajanani; Johnson, Margaret; Thorburn, Douglas; Harber, Mark; Chain, Benny; Stauss, Hans J.

    2016-01-01

    We tested whether multi-parameter immune phenotyping before or after renal ­transplantation can predict the risk of rejection episodes. Blood samples collected before and weekly for 3 months after transplantation were analyzed by multi-parameter flow cytometry to define 52 T cell and 13 innate lymphocyte subsets in each sample, producing more than 11,000 data points that defined the immune status of the 28 patients included in this study. Principle component analysis suggested that the patients with histologically confirmed rejection episodes segregated from those without rejection. Protein death 1 (PD-1)-expressing subpopulations of regulatory and conventional T cells had the greatest influence on the principal component segregation. We constructed a statistical tool to predict rejection using a support vector machine algorithm. The algorithm correctly identified 7 out of 9 patients with rejection, and 14 out of 17 patients without rejection. The immune profile before transplantation was most accurate in determining the risk of rejection, while changes of immune parameters after transplantation were less accurate in discriminating rejection from non-rejection. The data indicate that pretransplant immune subset analysis has the potential to identify patients at risk of developing rejection episodes, and suggests that the proportion of PD1-expressing T cell subsets may be a key indicator of rejection risk. PMID:27148254

  3. Clinical and pathological analysis of acute rejection following orthotopic liver transplantation

    Institute of Scientific and Technical Information of China (English)

    MA Yi; WANG Guo-dong; HE Xiao-shun; LI Jun-liang; ZHU Xiao-feng; HU Rui-de

    2009-01-01

    Background Acute rejection is one of the most important factors for prognosis following liver transplantation. With the use of potent immunosuppressants, acute rejection does not always present typical manifestations. Moreover, other complications often occur concomitantly after liver transplantation, which makes early diagnosis of acute rejection more difficult. Acute rejection is best diagnosed by liver biopsy. Differentiation of clinical manifestations and pathological features plays an important role in achieving individualized immunosuppressive treatment and prolonging long term survival of patients given orthotopic liver transplants.Methods From January 2004 to December 2006, 516 orthotopic liver transplantations were performed at the First Affiliated Hospital, Sun Yat-sen University. For patients who suffered acute rejection, clinical manifestations, histopathological features, diagnosis and anti-rejection treatment were summarized and analyzed. Results In 86 cases (16.7%), of the 516 recipients, 106 episodes of acute rejection occurred, which included 9 with histopathological borderline changes, 36 Banff Ⅰ rejections, 48 Banff Ⅱ and 13 Banff Ⅲ. Among these, 36 were cured by adjusting the dose of immunosuppressant and 65 were reversed by methylprednisolone pulse treatment. Five were methylprednisolone resistant, 3 of whom were given OKT3 treatment and 2 underwent liver retransplantation. Conclusions Due to potent immunosuppressive agents, acute rejection following an orthotopic liver transplantation lacks typical clinical manifestations and pathological features. Acute rejection is best diagnosed by liver biopsy. Designing rational individualized immunosuppressive regimen based on clinical and pathological features of acute rejection plays an important role in prolonging long term survival of patients.

  4. [Reasons for rejection of articles vor publication in the Nederlands Tijdschrift voor Geneeskunde in 1990].

    Science.gov (United States)

    Kan, C C; Lockefeer, J H; Overbeke, A J

    1991-05-11

    To deduce recommendations for authors which decrease the rejection probability we investigated retrospectively which reasons were mentioned in 1990 by the editorial board of the 'Nederlands Tijdschrift voor Geneeskunde' when it rejected original articles, reviews, clinical lessons and case reports, and whether length of the article, professional status of the first author, most relevant specialism and origin of the article influenced the rejection probability. Out of 547 articles 38% (208) were rejected; case reports were rejected most often (49%), reviews least often (33%). Peer review of original articles was the most thorough, of case studies the least. The most frequent reason for rejection in all categories was 'substantial shortcomings', particularly in the original articles (80%). Rejection of clinical lessons and case studies was relatively often due to criteria concerning the clinical message. Both rejected and accepted articles on average exceeded the length limit. Professional status and specialism were associated with a difference in rejection probability (chi 2, p less than 0.05). Specialists had the lowest rejection probability (31%). Nonspecialists benefited from specialist supervision. Articles originating from non-academic institutions were more often rejected than articles from academic centres. We advise authors to judge their articles by means of the criteria mentioned. Consultation of (methodological) experts, literature data bases, and (or) the editorial board can improve their chances. Non-specialists can benefit from the experience and expertise of specialists. In general, scientific attitude and willingness to alter the article according to editorial advice appear to have beneficial results.

  5. Late Acute Rejection Occuring in Liver Allograft Recipients

    Directory of Open Access Journals (Sweden)

    Eric M Yoshida

    1996-01-01

    Full Text Available To study the effect of immunosuppressive reduction on the incidence and consequence of late acute rejection (LAR in liver allograft recipients, mean daily prednisone dose, mean cyclosporine A (CsA trough and nadir levels were retrospectively reviewed for the nearest 12-week period preceding six episodes of LAR in five liver allograft recipients (group 1. Results were compared with those from a cohort of 12 liver allograft recipients who did not develop LAR (group 2. LAR was defined as acute rejection occurring more than 365 days post-transplantation. Median follow-up for both groups was similar (504 days, range 367 to 1050, versus 511 days, range 365 to 666, not significant. Mean trough CsA levels were lower in patients with LAR compared with those without (224±66 ng/mL versus 233±49 ng/mL but the difference was not statistically significant. In contrast, mean daily prednisone dose (2.5±1.6 mg/ day versus 6.5±2.9 mg/day, P=0.007 and CsA nadir values (129±60 ng/mL versus 186±40 ng/mL, P=0.03 were significantly lower in patients who developed LAR compared with those who did not. Five of six episodes (83% of LAR occurred in patients receiving less than 5 mg/day of prednisone, versus a single LAR episode in only one of 12 patients (8% receiving prednisone 5 mg/day or more (P=0.004. In all but one instance, LAR responded to pulse methylprednisolone without discernible affect on long term graft function. The authors conclude that liver allograft recipients remain vulnerable to acute rejection beyond the first post-transplant year; and reduction of immunosuppressive therapy, particularly prednisone, below a critical, albeit low dose, threshold increases the risk of LAR.

  6. Immune response and histology of humoral rejection in kidney transplantation.

    Science.gov (United States)

    González-Molina, Miguel; Ruiz-Esteban, Pedro; Caballero, Abelardo; Burgos, Dolores; Cabello, Mercedes; Leon, Miriam; Fuentes, Laura; Hernandez, Domingo

    2016-01-01

    The adaptive immune response forms the basis of allograft rejection. Its weapons are direct cellular cytotoxicity, identified from the beginning of organ transplantation, and/or antibodies, limited to hyperacute rejection by preformed antibodies and not as an allogenic response. This resulted in allogenic response being thought for decades to have just a cellular origin. But the experimental studies by Gorer demonstrating tissue damage in allografts due to antibodies secreted by B lymphocytes activated against polymorphic molecules were disregarded. The special coexistence of binding and unbinding between antibodies and antigens of the endothelial cell membranes has been the cause of the delay in demonstrating the humoral allogenic response. The endothelium, the target tissue of antibodies, has a high turnover, and antigen-antibody binding is non-covalent. If endothelial cells are attacked by the humoral response, immunoglobulins are rapidly removed from their surface by shedding and/or internalization, as well as degrading the components of the complement system by the action of MCP, DAF and CD59. Thus, the presence of complement proteins in the membrane of endothelial cells is transient. In fact, the acute form of antibody-mediated rejection was not demonstrated until C4d complement fragment deposition was identified, which is the only component that binds covalently to endothelial cells. This review examines the relationship between humoral immune response and the types of acute and chronic histological lesion shown on biopsy of the transplanted organ. Copyright © 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

  7. Perturbations in the Urinary Exosome in Transplant Rejection

    Directory of Open Access Journals (Sweden)

    Tara eSigdel

    2015-01-01

    Full Text Available Urine exosomes are small vesicles exocytosed into the urine by all renal epithelial cell types under normal physiologic and disease states. Urine exosomal proteins may mirror disease specific proteome perturbations in kidney injury. Analysis methodologies for the exosomal fraction of the urinary proteome were developed for comparing the urinary exosomal fraction versus unfractionated proteome for biomarker discovery. Urine exosomes were isolated by centrifugal filtration of urine samples collected from kidney transplant patients with and without acute rejection, which were biopsy matched. The proteomes of unfractionated whole urine (Uw and urine exosomes (Ue underwent mass spectroscopy-based quantitative proteonomics analysis. The proteome data were analyzed for significant differential protein abundances in acute rejection (AR. A total of 1018 proteins were identified in Uw and 349 proteins in Ue. 279 overlapped between the two urinary compartments and 70 proteins were unique to the Ue compartment. Of 349 exosomal proteins identified from transplant patients,220 had not been previously identified in the normal Ue fraction. 11 Ue proteins, functionally involved in an inflammatory and stress response, were more abundant in urine samples from patients with acute rejection, 3 of which are exclusive to the Ue fraction. Ue AR-specific biomarkers(8 were also detected in Uw, but since they were observed at significantly lower abundances in Uw, they were not significant for AR in Uw. A rapid urinary exosome isolation method and quantitative measurement of enriched Ue proteins was applied. Perturbed proteins in the exosomal compartment of urine collected from kidney transplant patients were specific to inflammatory responses, and were not observed in the Ue fraction from normal healthy subjects. Ue specific protein alterations in renal disease provide potential mechanistic insights and offer a unique panel of sensitive biomarkers for monitoring AR.

  8. A novel robust disturbance rejection anti-windup framework

    Science.gov (United States)

    Li, Guang; Herrmann, Guido; Stoten, David P.; Tu, Jiaying; Turner, Matthew C.

    2011-01-01

    In this article, we propose a novel anti-windup (AW) framework for coping with input saturation in the disturbance rejection problem of stable plant systems. This framework is based on the one developed by Weston and Postlethwaite (W&P) (Weston, P.F., and Postlethwaite, I. (2000), 'Linear Conditioning for Systems Containing Saturating Actuators', Automatica, 36, 1347-1354). The new AW-design improves the disturbance rejection performance over the design framework usually suggested for the coprime-factorisation based W&P-approach. Performance improvement is achieved by explicitly incorporating a transfer function, which represents the effect of the disturbance on the nonlinear loop, into the AW compensator synthesis. An extra degree of freedom is exploited for the coprime factorisation, resulting in an implicitly computed multivariable algebraic loop for the AW-implementation. Suggestions are made to overcome the algebraic loop problem via explicit computation. Furthermore, paralleling the results of former work (Turner, M.C., Herrmann, G., and Postlethwaite, I. (2007), 'Incorporating Robustness Requirements into Antiwindup Design', IEEE Transactions on Automatic Control, 52, 1842-1855), the additive plant uncertainty is incorporated into the AW compensator synthesis, by using a novel augmentation for the disturbance rejection problem. In this new framework, it is shown that the internal model control (IMC) scheme is optimally robust, as was the case in Turner, Herrmann, and Postlethwaite (2007) and Zheng and Morari (Zheng, A., and Morari, M. (1994), 'Anti-windup using Internal Model Control', International Journal of Control, 60, 1015-1024). The new AW approach is applied to the control of dynamically substructured systems (DSS) subject to external excitation signals and actuator limits. The benefit of this approach is demonstrated in the simulations for a small-scale building mass damper DSS and a quasi-motorcycle DSS.

  9. Medical students' career indecision and specialty rejection: roads not taken.

    Science.gov (United States)

    Kassebaum, D G; Szenas, P L

    1995-10-01

    The authors used data from the AAMC Matriculating Student Questionnaire and Medical School Graduation Questionnaire to ascertain how closely the specialty or subspecialty choices of the 1991 and 1994 graduates of U.S. medical schools matched the preferences they had declared when they were matriculated; the extent to which these students strongly considered and then rejected choices that arose during medical school; and the graduation choices of the substantial number of students in both cohorts who were undecided about their careers when they entered medical school. Approximately 80% of the graduates in both classes rejected the specialty intentions they had declared when they began medical school. However, matriculation interests in the generalist specialties--family practice, general pediatrics, and general internal medicine--were more enduring for the 1994 cohort, while interests in the medical, surgical, and support specialties were less so. Large percentages of the 1991 and 1994 cohorts were undecided about their careers at matriculation (20.8% and 26.2%, respectively), and nearly the same proportions remained undecided at graduation. However, more of the graduates in the 1994 cohort who had initially been undecided reached decisions favoring one of the generalist specialties than was true for the 1991 cohort. Nearly half the 1994 graduates had strongly considered and then rejected an alternative to their matriculation interest that arose during medical school. Within the generalist specialties, both early and later interests in family practice were more durable than were those in general pediatrics and general internal medicine: for every student who retreated from tentative interest in family practice, another student's interest was reinforced or kindled.(ABSTRACT TRUNCATED AT 250 WORDS)

  10. Nonlinear Feedforward Control for Wind Disturbance Rejection on Autonomous Helicopter

    DEFF Research Database (Denmark)

    Bisgaard, Morten; la Cour-Harbo, Anders; A. Danapalasingam, Kumeresan

    2010-01-01

    for the purpose. The model is inverted for the calculation of rotor collective and cyclic pitch angles given the wind disturbance. The control strategy is then applied on a small helicopter in a controlled wind environment and flight tests demonstrates the effectiveness and advantage of the feedforward controller.......This paper presents the design and verification of a model based nonlinear feedforward controller for wind disturbance rejection on autonomous helicopters. The feedforward control is based on a helicopter model that is derived using a number of carefully chosen simplifications to make it suitable...

  11. Muon identification and pion rejection in the 4th concept

    Indian Academy of Sciences (India)

    John Haupton

    2007-12-01

    We describe a completely new way to reconstruct and identify muons with high efficiency and very high pion rejection in the 4th concept detector. The dual-solenoid magnetic field allows the reconstruction and precision momentum measurement of muons down to a few GeV (just the energy loss in the 10-int calorimeter and the coil) and the dual-readout calorimeter provides a new, unique and powerful separation of muons from pions. We use test beam data for the calorimeter and calculations for the magnetic fields

  12. Rejection Mechanism in 2D Bounded Confidence Provides more Conformity

    CERN Document Server

    Huet, Sylvie; Jager, Wander

    2014-01-01

    We add a rejection mechanism (negative influence) into a two-dimensions bounded confidence model. The principle is that one shifts aways from a close attitude of one's interlocutor, when there is a strong disagreement on the other attitude. The model shows metastable clusters, which maintain themselves through opposite influences of competitor clusters. Our analysis and first experiments support the hypothesis that the number of clusters grows linearly with the inverse of the uncertainty, whereas this growth is quadratic in the bounded confidence model.

  13. Thermal storage for industrial process and reject heat

    Science.gov (United States)

    Duscha, R. A.; Masica, W. J.

    1978-01-01

    Industrial production uses about 40% of the total energy consumed in the United States. The major share of this is derived from fossil fuel. Potential savings of scarce fuel is possible through the use of thermal energy storage (TES) of reject or process heat for subsequent use. Results of study contracts awarded by the Department of Energy (DOE) and managed by the NASA Lewis Research Center have identified three especially significant industries where high temperature TES appears attractive - paper and pulp, iron and steel, and cement. Potential annual fuel savings with large scale implementation of near-term TES systems for these three industries is nearly 9 million bbl of oil.

  14. Active rejection of persistent disturbances in flexible space structures

    Science.gov (United States)

    Hwang, Cheng-Neng; Jayasuriya, Suhada; Parlos, Alexander G.; Sunkel, John W.

    1990-01-01

    A dynamic compensator for active rejection of persistent disturbances in flexible space structures is designed on the principle of the H(infinity)-optimization of the sensitivity transfer function matrix. A general state space solution is formulated to the multiinput multioutput H(infinity)-optimal control problem, allowing the use of the H(infinity)-optimal synthesis algorithm for the state-space models of space structures that result from model order reduction. Disturbances encountered in flexible space structures, such as shuttle docking, are investigated using the high-mode and the reduced-order models of a cantilevered two-bay truss, demonstrating the applicability of the H(infinity)-optimal approach.

  15. An observer with controller to detect and reject disturbances

    Science.gov (United States)

    de Jesús Rubio, José; Meléndez, Fidel; Figueroa, Maricela

    2014-03-01

    In this paper, a novel states observer is designed. This observer not only estimates the states, but also detects the disturbances by creating estimated signals. Then, both the observed states and detected disturbances are used in a control law to reject the disturbances, avoiding the requirement to know the states and disturbances. The observer is designed by the combination of the poles assignation and geometric techniques. Both the observer and controller work simultaneously. The proposed method is applied in an active suspension system and a liquid-level hydraulic system.

  16. Active disturbance rejection control of temperature for ultrastable optical cavities.

    Science.gov (United States)

    Pizzocaro, Marco; Calonico, Davide; Calosso, Claudio; Clivati, Cecilia; Costanzo, Giovanni A; Levi, Filippo; Mura, Alberto

    2013-02-01

    This paper describes the application of a novel active disturbance rejection control (ADRC) to the stabilization of the temperature of two ultra-stable Fabry-Perot cavities. The cavities are 10 cm long and entirely made of ultralow- expansion glass. The control is based on a linear extended state observer that estimates and compensates the disturbance in the system in real time. The resulting control is inherently robust and easy to tune. A digital implementation of ADRC gives a temperature instability of 200 μK at one day of integration time.

  17. Design and Modeling of a Variable Heat Rejection Radiator

    Science.gov (United States)

    Miller, Jennifer R.; Birur, Gajanana C.; Ganapathi, Gani B.; Sunada, Eric T.; Berisford, Daniel F.; Stephan, Ryan

    2011-01-01

    Variable Heat Rejection Radiator technology needed for future NASA human rated & robotic missions Primary objective is to enable a single loop architecture for human-rated missions (1) Radiators are typically sized for maximum heat load in the warmest continuous environment resulting in a large panel area (2) Large radiator area results in fluid being susceptible to freezing at low load in cold environment and typically results in a two-loop system (3) Dual loop architecture is approximately 18% heavier than single loop architecture (based on Orion thermal control system mass) (4) Single loop architecture requires adaptability to varying environments and heat loads

  18. Acute appendicitis mistaken as acute rejection in renal transplant recipients.

    Directory of Open Access Journals (Sweden)

    Talwalkar N

    1994-01-01

    Full Text Available Case histories of 2 renal transplant recipients are reported who had presenting features of fever, leukocytosis and pain/tenderness over right iliac fossa and were diagnosed to be due to acute appendicitis rather than more commonly suspected acute rejection episode which has very similar features. Diagnosis of acute appendicitis was suspected on the basis of rectal examination and later confirmed by laparotomy. The purpose of this communication is to emphasize the need for proper diagnosis in patient with such presentation; otherwise wrong treatment may be received.

  19. Automatic Carrier Landing System with Gust-rejection Capability

    Institute of Scientific and Technical Information of China (English)

    曹东; 杨一栋; 余勇; 范彦铭

    2004-01-01

    A new direct-lift control carrier landing mode is advanced, and it is proved to be very effective to keep the attitude angle and path angle constant when the aircraft is in the blind area of tracking radar and the guidance system is shut off. The direct-lift control mode is achieved with the symmetric deflection of the flaps and dynamic decoupling for minor disturbance of the angle of attack. This mode changes an aircraft' s model from a short-period oscillation model to a non-oscillation one, which could evidently increase the gust-rejection capability of the aircraft.

  20. Chinese Journal of Population, Resources and Environment announces cooperation with Thomson Reuters —— Adopts world leading online peer review system ScholarOne Manuscripts

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The Chinese Journal of Population, Resources and Environment, (ISSN 1004-2857, CN 37-1202/N), recently adopted ScholarOne Manuscripts to manage its submissions and peer review process. The comprehensive online platform will help further promote academic exchange by streamlining the editorial and publication process: authors enjoy ease of submission and ability to track manuscript review status while editors can manage review tasks in a dynamic, fully-integrated interface that enables the most informed decision-making.

  1. Publication rates of manuscript presentations at the American College of Foot and Ankle Surgeons Annual Scientific Conference between 1999 and 2008.

    Science.gov (United States)

    Roukis, Thomas S

    2011-01-01

    Publication is the ultimate desired end point of scientific research. However, oral manuscript presentations of research studies are often referenced in textbooks, journal articles, and industry white papers, and, as a result, influence treatment care plans. No data exist for the actual publication rate of podiatric foot and ankle surgery oral manuscript presentations. Therefore, the objective of this study was to determine the actual publication rates of oral manuscript presentations at the American College of Foot and Ankle Surgeons (ACFAS) Annual Scientific Conference over 10 years. Print or electronic media for the ACFAS Annual Scientific Conference official program between 1999 and 2008 were obtained. Each year's official program was hand searched for any oral manuscript presentation, and, when identified, the title and authors were individually searched through electronic internet-based search engines to determine whether an oral manuscript presentation had been followed by publication of a full-text article. Additionally, pertinent journals were hand searched for potential articles. A total of 67.5% (139/206) oral manuscript presentations were ultimately published in 1 of 12 medical journals in a mean of 14.5 months. All journals except one (91.7%) represented peer-reviewed journals. The publication rate of oral manuscript presentations at the ACFAS Annual Scientific Conference is similar to or greater than orthopaedic subspecialties, including foot and ankle surgery, publication rates. Based on the above, attendees of the ACFAS Annual Scientific Conference should be aware that the majority of oral manuscript material presented at the ACFAS Annual Scientific Conference can be considered as accurate because they survive the rigors of the peer-review process more than two thirds of the time.

  2. Makam descriptions, classifications ın 15th century music manuscripts during ottoman period and a theorist of passing period: Ladikli Mehmet Çelebi

    Directory of Open Access Journals (Sweden)

    N. Oya Levendoğlu Öner

    2011-10-01

    Full Text Available The subject of makam descriptions goes back to Pre-Ottoman Empire period. In this period, makam phenomenon which is often studied in the middle age manuscripts of Islamic world was considered as a part of mathematic science. First Turkish music manuscripts had written in 15th Century during Otoman period. This study is aimed to put forward how considered makam descriptions and classifications by author in this period. Eight manuscript have analyzed and compared with each other which are Arabic, Persian and ancient Turkish. It is seen that makams were described with short seyir (melodic development, makam circles and on the accord system of instruments in Turkish manuscripts which are written in 15th century. These description ways are different more than Arabic and Persian manuscripts. Makams were described with alphabetic notation gave their scale and interval in those manuscripts. There are also some differences with regard to makam classifications between these two schools. It is concluded that Ladikli Mehmet Çelebi who is one of this period’s aouthor improved an characteristic makam description synthesizing each two description way.

  3. Sugar or spice: Using I3 metatheory to understand how and why glucose reduces rejection-related aggression.

    Science.gov (United States)

    Pfundmair, Michaela; DeWall, C Nathan; Fries, Veronika; Geiger, Babette; Krämer, Tanya; Krug, Sebastian; Frey, Dieter; Aydin, Nilüfer

    2015-01-01

    Social rejection can increase aggression, especially among people high in rejection sensitivity. Rejection impairs self-control, and deficits in self-control often result in aggression. A dose of glucose can counteract the effect of situational factors that undermine self-control. But no research has integrated these literatures to understand why rejection increases aggression, and how to reduce it. Using the I(3) model of aggression, we proposed that aggression would be highest under conditions of high instigation (rejection), high impellance (high rejection sensitivity), and low inhibition (drinking a beverage sweetened with a sugar substitute instead of glucose). As predicted, aggression was highest among participants who experienced social rejection, were high in rejection sensitivity, and drank a placebo beverage. A dose of glucose reduced aggression, especially among rejected people high in rejection sensitivity. These findings point to the importance of self-control in understanding why social rejection increases aggression, and how to prevent it.

  4. ALLUSION AND REMINISCENCE IN THE MANUSCRIPT OF FYODOR DOSTOEVSKY'S NOVEL "THE RAW YOUTH" (VASILY ZHUKOVSKY'S ELEGY "A COUNTRY CHURCHYARD"

    Directory of Open Access Journals (Sweden)

    Natalia Alexandrovna Tarasova

    2013-11-01

    Full Text Available The article examines the intertextual relations in the manuscript and in the printed text of Fyodor Dostoyevsky’s novel The Raw Youth, using an example of the allusion to the Vasily Zhukovsky’s elegy A Country Churchyard and analyzing the specifics of its functioning in the context of the novel’s narration. The main objective of the work was to establish the internal trends of the author’s ideas’ development in the novel. The tasks were to investigate the problem of studying intertextual relations in the works of Fyodor Dostoyevsky (since the theoretical aspects of the problem were not specifically addressed in previous studies and to analyze the literary material using the textual approach. The source text, which is important for the formation of intertextual relations, is examined not as an individual piece of writing but in the context of the The Raw Youth manuscripts that helps to clarify the nature of its artistic interpretation and the conjunction of folkloristic and biblical concepts in the novel.

  5. Preliminary Remarks on a Collection of Prajñāpāramitā Manuscripts from 'On Ke ru Temple

    Institute of Scientific and Technical Information of China (English)

    Matthew T. Kapstein

    2013-01-01

    During the summer of 2002 I had the opportunity to visit briefly the Temple of 'On Keru in Lhokha (Shannan), TAR, under the kind auspices of the Tibet Academy of Social Science and in collaboration with the Tibet Himalayan Digital Library project based at the University of Virginia. It was rumored, at the time, that 'On Keru—which is supposed to have been founded during the reign of the Btsan po Khri Lde gtsug btsan in the early 8th century—preserved a collection of very old manuscripts dating back to the period of the Tibetan kings of the 8th-9th centuries. Although the short time available to me was not sufficient to permit a detailed inspection of the collection—it was not possible to confirm, for example, the presence of Old Tibetan manuscripts—I was nevertheless able to identify parts of a Prajñāpāramitā collection of the 12th century. As this material is of considerable interest for the history of the Tibetan book, in terms of its material aspects including paper, ink and illumination, I will present here the information I was able to assemble. However, the manuscripts in question require more detailed study. It is my hope that this brief presentation will inspire an effort to investigate thoroughly the 'On Keru collection.

  6. Radiocarbon dating of ancient Japanese calligraphy sheets and the discovery of 45 letters of a lost manuscript

    Energy Technology Data Exchange (ETDEWEB)

    Oda, H. [Nagoya Univ. (Japan). Center for Chronological Research; Yasu, H. [Taga High School, Hitachi, Ibaragi (Japan); Ikeda, K. [Chuo Univ., Tokyo (Japan). Faculty of Letters; Sakamoto, M. [National Museum of Japanese History, Sakura, Chiba (Japan); Yoshizawa, Y.

    2011-07-01

    The Miidera-gire is an ancient paper sheet with different, elegant calligraphy on both sides. One side contains a part of a Buddhist scripture from around the ninth to the twelfth century and written in cursive hand, while the other side contains a part of Monzen (an anthology of Chinese literary works). The paleographical style of this Monzen seems to be older than that of the Buddhist scripture and is similar to some Chinese manuscripts written in the Tang Dynasty (AD 618-907). However, amid these elegant calligraphic writings, there exist many copies and counterfeits that were written several centuries later. We, therefore, measured the radiocarbon age of the Miidera-gire by using accelerator mass spectrometry. The calibrated radiocarbon age indicated 666-776 [cal AD] (2{sigma} error), thus leading to the conclusion that the Monzen was first written on the obverse side, and long afterwards, the Buddhist scripture was written on the reverse side. Since only a few incomplete books of Monzen were written before the ninth century, this calligraphy is one of the oldest of the existing Monzen manuscripts. (orig.)

  7. Anatomical Terms in J. Basanavičius’ Manuscript Anatomijos ir medicinos vardyno medžiaga

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    Nijolė Litevkienė

    2011-12-01

    Full Text Available The historical evolution of anatomical terms dates to antiquity, to the writings of Hippocrates. The historical development of Lithuanian anatomical terminology goes back to the seventeenth century. Anatomical terminology, as a comprehensive system of the names of human body parts is being compiled gradually. The originator of Lithuanian medical terminology was J. Basanavičius. The research paper aims to analyze anatomical terms used in J. Basanavičius’ manuscript Anatomijos ir medicinos vardyno medžiaga (further BM and to compare them with the terms in the Dictionary of Medical Terms ( Medicinos terminų žodynas 1980. The research focuses on the analysis of some aspects of differentiation and congruity of simple and multi-word anatomical terms of the manuscript and the dictionary. About 270 Lithuanian anatomical terms with Russian and Latin equivalents were collected by J. Basanavičius. The results show that the major part of the terms are different, the lesser part of the terms are identical.

  8. Potential use of power plant reject heat in commercial aquaculture

    Energy Technology Data Exchange (ETDEWEB)

    Olszewski, M.

    1977-01-01

    Current research and commercial activities in aquaculture operations have been reviewed. An aquaculture system using mostly herbivorous species in pond culture is proposed as a means of using waste heat to produce reasonably priced protein. The system uses waste water streams, such as secondary sewage effluent, animal wastes, or some industrial waste streams as a primary nutrient source to grow algae, which is fed to fish and clams. Crayfish feed on the clam wastes thereby providing a clean effluent from the aquaculture system. Alternate fish associations are presented and it appears that a carp or tilapia association is desirable. An aquaculture system capable of rejecting all the waste heat from a 1000-MW(e) power station in winter can accommodate about half the summer heat rejection load. The aquaculture facility would require approximately 133 ha and would produce 4.1 x 10/sup 5/ kg/year of fish, 1.5 x 10/sup 6/ kg/year of clam meat, and 1.5 x 10/sup 4/ kg/year of live crayfish. The estimated annual pretax profit from this operation is one million dollars. Several possible problem areas have been identified. However, technical solutions appear to be readily available to solve these problems. The proposed system shows considerable economic promise. Small scale experiments have demonstrated the technical feasibility of various components of the system. It therefore appears that a pilot scale experimental facility should be operated.

  9. Identification and rejection of scattered neutrons in AGATA

    CERN Document Server

    Şenyiğit, M; Akkoyun, S; Kaşkaş, A; Bazzacco, D; Nyberg, J; Recchia, F; Brambilla, S; Camera, F; Crespi, F C L; Farnea, E; Giaz, A; Gottardo, A; Kempley, R; Ljungvall, J; Mengoni, D; Michelagnoli, C; Million, B; Palacz, M; Pellegri, L; Riboldi, S; Şahin, E; Söderström, P A; Dobon, J J Valiente

    2013-01-01

    Gamma rays and neutrons, emitted following spontaneous fission of 252Cf, were measured in an AGATA experiment performed at INFN Laboratori Nazionali di Legnaro in Italy. The setup consisted of four AGATA triple cluster detectors (12 36-fold segmented high-purity germanium crystals), placed at a distance of 50 cm from the source, and 16 HELENA BaF2 detectors. The aim of the experiment was to study the interaction of neutrons in the segmented high-purity germanium detectors of AGATA and to investigate the possibility to discriminate neutrons and gamma rays with the gamma-ray tracking technique. The BaF2 detectors were used for a time-of-flight measurement, which gave an independent discrimination of neutrons and gamma rays and which was used to optimise the gamma-ray tracking-based neutron rejection methods. It was found that standard gamma-ray tracking, without any additional neutron rejection features, eliminates effectively most of the interaction points due to recoiling Ge nuclei after elastic scattering of...

  10. Aire deficiency promotes TRP-1 specific immune rejection of melanoma

    Science.gov (United States)

    Zhu, Meng-Lei; Nagavalli, Anil; Su, Maureen A.

    2013-01-01

    The thymic transcription factor AIRE prevents autoimmunity in part by promoting expression of tissue-specific self-antigens, which include many cancer antigens. For example, AIRE-deficient patients are predisposed to vitiligo, an autoimmune disease of melanocytes that is often triggered by efficacious immunotherapies against melanoma. Therefore, we hypothesized that Aire deficiency in mice may elevate immune responses to cancer and provide insights into how such responses might be triggered. In this study, we show that Aire deficiency decreases thymic expression of TRP-1 (TYRP1), which is a self-antigen in melanocytes and a cancer antigen in melanomas. Aire deficiency resulted in defective negative selection of TRP-1 specific T cells without affecting thymic numbers of regulatory T cells. Aire deficient mice displayed elevated T cell immune responses that were associated with suppression of melanoma outgrowth. Further, transplantation of Aire-deficient thymic stroma was sufficient to confer more effective immune rejection of melanoma in an otherwise Aire wildtype host. Together, our work showed how Aire deficiency can enhance immune responses against melanoma, and how manipulating TRP-1 specific T cell negative selection may offer a logical strategy to enhance immune rejection of melanoma. PMID:23370329

  11. Aire deficiency promotes TRP-1-specific immune rejection of melanoma.

    Science.gov (United States)

    Zhu, Meng-Lei; Nagavalli, Anil; Su, Maureen A

    2013-04-01

    The thymic transcription factor autoimmune regulator (Aire) prevents autoimmunity in part by promoting expression of tissue-specific self-antigens, which include many cancer antigens. For example, AIRE-deficient patients are predisposed to vitiligo, an autoimmune disease of melanocytes that is often triggered by efficacious immunotherapies against melanoma. Therefore, we hypothesized that Aire deficiency in mice may elevate immune responses to cancer and provide insights into how such responses might be triggered. In this study, we show that Aire deficiency decreases thymic expression of TRP-1 (TYRP1), which is a self-antigen in melanocytes and a cancer antigen in melanomas. Aire deficiency resulted in defective negative selection of TRP-1-specific T cells without affecting thymic numbers of regulatory T cells. Aire-deficient mice displayed elevated T-cell immune responses that were associated with suppression of melanoma outgrowth. Furthermore, transplantation of Aire-deficient thymic stroma was sufficient to confer more effective immune rejection of melanoma in an otherwise Aire wild-type host. Together, our work showed how Aire deficiency can enhance immune responses against melanoma and how manipulating TRP-1-specific T-cell negative selection may offer a logical strategy to enhance immune rejection of melanoma. ©2013 AACR.

  12. Antibody-Mediated Rejection: Pathogenesis, Prevention, Treatment, and Outcomes

    Directory of Open Access Journals (Sweden)

    Olivia R. Blume

    2012-01-01

    Full Text Available Antibody-mediated rejection (AMR is a major cause of late kidney transplant failure. It is important to have an understanding of human-leukocyte antigen (HLA typing including well-designed studies to determine anti-MHC-class-I-related chain A (MICA and antibody rejection pathogenesis. This can allow for more specific diagnosis and treatment which may improve long-term graft function. HLA-specific antibody detection prior to transplantation allows one to help determine the risk for AMR while detection of DSA along with a biopsy confirms it. It is now appreciated that biopsy for AMR does not have to include diffuse C4d, but does require a closer look at peritubular capillary microvasculature. Although plasmapheresis (PP is effective in removing alloantibodies (DSAs from the circulation, rebound synthesis of alloantibodies can occur. Splenectomy is used in desensitization protocols for ABO incompatible transplants as well as being found to treat AMR refractory to conventional treatment. Also used are agents targeted for plasma cells, B cells, and the complement cascade which are bortezomib rituximab and eculizumab, respectively.

  13. Nationalism and patriotism: national identification and out-group rejection.

    Science.gov (United States)

    Mummendey, A; Klink, A; Brown, R

    2001-06-01

    It is argued that the differentiation between nationalism and patriotism proposed in the literature can be seen as analogous to judgments based on different types of comparisons: intergroup comparisons with other nations are associated with intergroup behaviour that corresponds to nationalism, whereas temporal or standard comparisons are linked with behaviour that corresponds to patriotism. Four studies (N = 103, 107, 96 and 105) conducted in Germany and Britain examined the hypothesis that national identification and in-group evaluation only show a reliable relationship with out-group rejection under an intergroup comparison orientation. Participants were primed with either an intergroup comparison, a temporal comparison or no explicit comparison orientation. A subsequent questionnaire assessed in-group (own country) identification, in-group evaluation (i.e. national pride) and rejection of national out-groups. Across all four studies, both in-group identification and in-group evaluation show a stronger correlation with out-group derogation if participants were primed with an intergroup comparison orientation compared to temporal and control conditions. Results are discussed with regard to nationalism and patriotism as well as Hinkle and Brown's (1990) model on relational vs. autonomous orientations.

  14. fMRI Artefact Rejection and Sleep Scoring Toolbox

    Directory of Open Access Journals (Sweden)

    Yves Leclercq

    2011-01-01

    Full Text Available We started writing the “fMRI artefact rejection and sleep scoring toolbox”, or “FAST”, to process our sleep EEG-fMRI data, that is, the simultaneous recording of electroencephalographic and functional magnetic resonance imaging data acquired while a subject is asleep. FAST tackles three crucial issues typical of this kind of data: (1 data manipulation (viewing, comparing, chunking, etc. of long continuous M/EEG recordings, (2 rejection of the fMRI-induced artefact in the EEG signal, and (3 manual sleep-scoring of the M/EEG recording. Currently, the toolbox can efficiently deal with these issues via a GUI, SPM8 batching system or hand-written script. The tools developed are, of course, also useful for other EEG applications, for example, involving simultaneous EEG-fMRI acquisition, continuous EEG eye-balling, and manipulation. Even though the toolbox was originally devised for EEG data, it will also gracefully handle MEG data without any problem. “FAST” is developed in Matlab as an add-on toolbox for SPM8 and, therefore, internally uses its SPM8-meeg data format. “FAST” is available for free, under the GNU-GPL.

  15. Parametric Adaptive Radar Detector with Enhanced Mismatched Signals Rejection Capabilities

    Directory of Open Access Journals (Sweden)

    Liu Bin

    2010-01-01

    Full Text Available We consider the problem of adaptive signal detection in the presence of Gaussian noise with unknown covariance matrix. We propose a parametric radar detector by introducing a design parameter to trade off the target sensitivity with sidelobes energy rejection. The resulting detector merges the statistics of Kelly's GLRT and of the Rao test and so covers Kelly's GLRT and the Rao test as special cases. Both invariance properties and constant false alarm rate (CFAR behavior for this detector are studied. At the analysis stage, the performance of the new receiver is assessed and compared with several traditional adaptive detectors. The results highlight better rejection capabilities of this proposed detector for mismatched signals. Further, we develop two two-stage detectors, one of which consists of an adaptive matched filter (AMF followed by the aforementioned detector, and the other is obtained by cascading a GLRT-based Subspace Detector (SD and the proposed adaptive detector. We show that the former two-stage detector outperforms traditional two-stage detectors in terms of selectivity, and the latter yields more robustness.

  16. Shotgun Proteomics Identifies Proteins Specific for Acute Renal Transplant Rejection

    Science.gov (United States)

    Sigdel, Tara K.; Kaushal, Amit; Gritsenko, Marina; Norbeck, Angela D.; Qian, Wei-Jun; Xiao, Wenzhong; Camp, David G.; Smith, Richard D.; Sarwal, Minnie M.

    2010-01-01

    Acute rejection (AR) remains the primary risk factor for renal transplant outcome; development of non-invasive diagnostic biomarkers for AR is an unmet need. We used shotgun proteomics applying LC-MS/MS and ELISA to analyze a set of 92urine samples, from patients with AR, stable grafts (STA), proteinuria (NS), and healthy controls (HC). A total of 1446 urinary proteins were identified along with a number of NS specific, renal transplantation specific and AR specific proteins. Relative abundance of identified urinary proteins was measured by protein-level spectral counts adopting a weighted fold-change statistic, assigning increased weight for more frequently observed proteins. We have identified alterations in a number of specific urinary proteins in AR, primarily relating to MHC antigens, the complement cascade and extra-cellular matrix proteins. A subset of proteins (UMOD, SERPINF1 and CD44), have been further cross-validated by ELISA in an independent set of urine samples, for significant differences in the abundance of these urinary proteins in AR. This label-free, semi-quantitative approach for sampling the urinary proteome in normal and disease states provides a robust and sensitive method for detection of urinary proteins for serial, non-invasive clinical monitoring for graft rejection after kidney transplantation. PMID:20543976

  17. Shotgun Proteomics Identifies Proteins Specific for Acute Renal Transplant Rejection

    Energy Technology Data Exchange (ETDEWEB)

    Sigdel, Tara K.; Kaushal, Amit; Gritsenko, Marina A.; Norbeck, Angela D.; Qian, Weijun; Xiao, Wenzhong; Camp, David G.; Smith, Richard D.; Sarwal, Minnie M.

    2010-01-04

    Acute rejection (AR) remains the primary risk factor for renal transplant outcome; development of non-invasive diagnostic biomarkers for AR is an unmet need. We used shotgun proteomics using LC-MS/MS and ELISA to analyze a set of 92 urine samples, from patients with AR, stable grafts (STA), proteinuria (NS), and healthy controls (HC). A total of 1446 urinary proteins were identified along with a number of NS specific, renal transplantation specific and AR specific proteins. Relative abundance of identified urinary proteins was measured by protein-level spectral counts adopting a weighted fold-change statistic, assigning increased weight for more frequently observed proteins. We have identified alterations in a number of specific urinary proteins in AR, primarily relating to MHC antigens, the complement cascade and extra-cellular matrix proteins. A subset of proteins (UMOD, SERPINF1 and CD44), have been further cross-validated by ELISA in an independent set of urine samples, for significant differences in the abundance of these urinary proteins in AR. This label-free, semi-quantitative approach for sampling the urinary proteome in normal and disease states provides a robust and sensitive method for detection of urinary proteins for serial, non-invasive clinical monitoring for graft rejection after

  18. A Multisurface Interpersonal Circumplex Assessment of Rejection Sensitivity.

    Science.gov (United States)

    Cain, Nicole M; De Panfilis, Chiara; Meehan, Kevin B; Clarkin, John F

    2017-01-01

    Individuals high in rejection sensitivity (RS) are at risk for experiencing high levels of interpersonal distress, yet little is known about the interpersonal profiles associated with RS. This investigation examined the interpersonal problems, sensitivities, and values associated with RS in 2 samples: 763 multicultural undergraduate students (Study 1) and 365 community adults (Study 2). In Study 1, high anxious RS was associated with socially avoidant interpersonal problems, whereas low anxious RS was associated with vindictive interpersonal problems. In Study 2, we assessed both anxious and angry expectations of rejection. Circumplex profile analyses showed that the high anxious RS group reported socially avoidant interpersonal problems, sensitivities to remoteness in others, and valuing connections with others, whereas the high angry RS group reported vindictive interpersonal problems, sensitivities to submissiveness in others, and valuing detached interpersonal behavior. Low anxious RS was related to domineering interpersonal problems, sensitivity to attention-seeking behavior, and valuing detached interpersonal behavior, whereas low angry RS was related to submissive interpersonal problems, sensitivity to attention-seeking behavior, and valuing receiving approval from others. Overall, results suggest that there are distinct interpersonal profiles associated with varying levels and types of RS.

  19. Gender nonconformity, childhood rejection, and adult attachment: a study of gay men.

    Science.gov (United States)

    Landolt, Monica A; Bartholomew, Kim; Saffrey, Colleen; Oram, Doug; Perlman, Daniel

    2004-04-01

    Several childhood factors are reported to be associated with a homosexual orientation in men, including gender nonconformity and rejection by parents and peers. The purpose of this study was to explore the associations between these childhood factors and attachment anxiety (the tendency to experience anxiety regarding potential loss and rejection in close relationships) and attachment avoidance (the tendency to avoid versus seek out closeness in relationships) in gay and bisexual men. A community sample of 191 gay and bisexual men completed questionnaires and an attachment interview. Gender nonconformity was significantly associated with paternal, maternal, and peer rejection in childhood. In addition, paternal and peer rejection, but not maternal rejection, independently predicted attachment anxiety. Peer rejection and, to a lesser extent, paternal rejection mediated the association between gender nonconformity and attachment anxiety. Finally, peer rejection mediated the association between paternal rejection and attachment avoidance. Findings highlight the role of gender nonconformity in contributing to childhood rejection and the importance of peer relationships in the socialization of gay men.

  20. A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation.

    Science.gov (United States)

    Khatri, Purvesh; Roedder, Silke; Kimura, Naoyuki; De Vusser, Katrien; Morgan, Alexander A; Gong, Yongquan; Fischbein, Michael P; Robbins, Robert C; Naesens, Maarten; Butte, Atul J; Sarwal, Minnie M

    2013-10-21

    Using meta-analysis of eight independent transplant datasets (236 graft biopsy samples) from four organs, we identified a common rejection module (CRM) consisting of 11 genes that were significantly overexpressed in acute rejection (AR) across all transplanted organs. The CRM genes could diagnose AR with high specificity and sensitivity in three additional independent cohorts (794 samples). In another two independent cohorts (151 renal transplant biopsies), the CRM genes correlated with the extent of graft injury and predicted future injury to a graft using protocol biopsies. Inferred drug mechanisms from the literature suggested that two FDA-approved drugs (atorvastatin and dasatinib), approved for nontransplant indications, could regulate specific CRM genes and reduce the number of graft-infiltrating cells during AR. We treated mice with HLA-mismatched mouse cardiac transplant with atorvastatin and dasatinib and showed reduction of the CRM genes, significant reduction of graft-infiltrating cells, and extended graft survival. We further validated the beneficial effect of atorvastatin on graft survival by retrospective analysis of electronic medical records of a single-center cohort of 2,515 renal transplant patients followed for up to 22 yr. In conclusion, we identified a CRM in transplantation that provides new opportunities for diagnosis, drug repositioning, and rational drug design.

  1. Stomaching rejection: Self-compassion and self-esteem moderate the impact of daily social rejection on restrictive eating behaviours among college women.

    Science.gov (United States)

    Beekman, Janine B; Stock, Michelle L; Howe, George W

    2017-05-05

    The present study examined whether having high self-esteem or a self-compassionate perspective help mitigate the impact of daily social rejection on negative affect and restrictive eating behaviours. Following a baseline survey assessing self-esteem and self-compassion, 121 college women completed online daily diaries for one week. Negative affect and restrictive eating behaviours. On days when women reported more rejection, they also reported higher restrictive eating behaviours and greater negative affect. Effects were moderated by self-esteem and self-compassion, such that the lower participants were in self-esteem or self-compassion, the stronger the positive relation between rejection and negative affect and restrictive eating. However, only the common humanity/isolation dimension of self-compassion significantly moderated daily effects of rejection when controlling for self-esteem. Mediated moderation results reveal different mechanisms by which self-esteem and self-compassion buffer against rejections' effects on affect and restrictive eating. Self-compassion and self-esteem influence the complex impact that social rejection has on affect and restrictive eating. More than other dimensions of self-compassion or self-esteem, remembering one's common humanity can result in a healthier response to social rejection.

  2. Forgotten marginalia and the French and Latin manuscript tradition in Le Mirouer des simples ames by Marguerite Porete

    Directory of Open Access Journals (Sweden)

    García Acosta, Pablo

    2014-06-01

    Full Text Available This article advocates a fresh critical study of the manuscripts of the “heretical” book, Le Mirouer des simples ames by Marguerite dicta Porete, and an examination of codicological evidence which neither the standard editions nor the modern translations take into account. It argues for analysis of the codex traditionally known as the Chantilly manuscript (Musée Condé, ms. F xiv 26, cat. 157 and of the manuscripts of the Latin branch preserved in the Vatican Library (Biblioteca Apostolica Vaticana, Vat. Lat. 4355; Cod. Rossianus 4; Cod. Chigianus B IV 41; Cod. Chigianus C IV 85 and Vat. Lat. 4953. The analysis focuses on the marginal marks (maniculae, nota bene and iconography which demonstrate that those books were used by active readers. The article also highlights the way in which the marginal marks provide us with information about the transmission and reception of the Mirror, and classifi es them according to function, depending on whether they facilitate access to, evaluate or even contribute to the meaning of the text of the Mirror itself.En las páginas siguientes reivindicamos un retorno crítico al estudio de los manuscritos del libro “herético” escrito por Marguerite dicta Porete (Le Mirouer des simples ames para estudiar aspectos codicológicos que ni las ediciones estándar ni las traducciones modernas han tenido en cuenta. Para ello, proponemos una serie de análisis del llamado “manuscrito de Chantilly” (Musée Condé, ms. F xiv 26, cat. 157 y de los manuscritos de la tradición latina de la Biblioteca Vaticana (Biblioteca Apostolica Vaticana, Vat. Lat. 4355; Cod. Rossianus 4; Cod. Chigianus B IV 41; Cod. Chigianus C IV 85 y Vat. Lat. 4953 basados en las anotaciones marginales (manículas, nota bene e iconografía que identifican estos libros más como dispositivos de lectura que como meros soportes materiales de un texto. Mostraremos cómo tales elementos nos dotan de información sobre la transmisión del texto y

  3. Social exclusion in middle childhood: rejection events, slow-wave neural activity, and ostracism distress.

    Science.gov (United States)

    Crowley, Michael J; Wu, Jia; Molfese, Peter J; Mayes, Linda C

    2010-01-01

    This study examined neural activity with event-related potentials (ERPs) in middle childhood during a computer-simulated ball-toss game, Cyberball. After experiencing fair play initially, children were ultimately excluded by the other players. We focused specifically on “not my turn” events within fair play and rejection events within social exclusion. Dense-array ERPs revealed that rejection events are perceived rapidly. Condition differences (“not my turn” vs. rejection) were evident in a posterior ERP peaking at 420 ms consistent, with a larger P3 effect for rejection events indicating that in middle childhood rejection events are differentiated in ostracism, including subgenual cortex, ventral anterior cingulate cortex, and insula, was greater for rejection events vs. “not my turn” events.

  4. "I'm worth more than that": trait positivity predicts increased rejection of unfair financial offers.

    Directory of Open Access Journals (Sweden)

    Barnaby D Dunn

    Full Text Available Humans react strongly to unfairness, sometimes rejecting inequitable proposals even if this sacrifices personal financial gain. Here we explored whether emotional dispositions--trait tendencies to experience positive or negative feelings--shape the rejection of unfair financial offers. Participants played an Ultimatum Game, where the division of a sum of money is proposed and the player can accept or reject this offer. Individuals high in trait positivity and low in trait negativity rejected more unfair offers. These relationships could not be explained by existing accounts which argue that rejection behaviour results from a failure to regulate negative emotions, or serves to arbitrate social relationships and identity. Instead, the relationship between dispositional affect and rejection behaviour may be underpinned by perceived self worth, with those of a positive disposition believing that they are "worth more than that" and those of a negative disposition resigning themselves to "taking the crumbs from under the table".

  5. "I'm worth more than that": trait positivity predicts increased rejection of unfair financial offers.

    Science.gov (United States)

    Dunn, Barnaby D; Makarova, Dasha; Evans, David; Clark, Luke

    2010-12-08

    Humans react strongly to unfairness, sometimes rejecting inequitable proposals even if this sacrifices personal financial gain. Here we explored whether emotional dispositions--trait tendencies to experience positive or negative feelings--shape the rejection of unfair financial offers. Participants played an Ultimatum Game, where the division of a sum of money is proposed and the player can accept or reject this offer. Individuals high in trait positivity and low in trait negativity rejected more unfair offers. These relationships could not be explained by existing accounts which argue that rejection behaviour results from a failure to regulate negative emotions, or serves to arbitrate social relationships and identity. Instead, the relationship between dispositional affect and rejection behaviour may be underpinned by perceived self worth, with those of a positive disposition believing that they are "worth more than that" and those of a negative disposition resigning themselves to "taking the crumbs from under the table".

  6. Mouse model of alloimmune-induced vascular rejection and transplant arteriosclerosis.

    Science.gov (United States)

    Enns, Winnie; von Rossum, Anna; Choy, Jonathan

    2015-05-17

    Vascular rejection that leads to transplant arteriosclerosis (TA) is the leading representation of chronic heart transplant failure. In TA, the immune system of the recipient causes damage of the arterial wall and dysfunction of endothelial cells and smooth muscle cells. This triggers a pathological repair response that is characterized by intimal thickening and luminal occlusion. Understanding the mechanisms by which the immune system causes vasculature rejection and TA may inform the development of novel ways to manage graft failure. Here, we describe a mouse aortic interposition model that can be used to study the pathogenic mechanisms of vascular rejection and TA. The model involves grafting of an aortic segment from a donor animal into an allogeneic recipient. Rejection of the artery segment involves alloimmune reactions and results in arterial changes that resemble vascular rejection. The basic technical approach we describe can be used with different mouse strains and targeted interventions to answer specific questions related to vascular rejection and TA.

  7. Rejected by Family for Being Gay or Lesbian: Portrayals, Perceptions, and Resilience.

    Science.gov (United States)

    Carastathis, Geoffrey S; Cohen, Lynne; Kaczmarek, Elizabeth; Chang, Paul

    2017-01-01

    A myriad of negative psychosocial outcomes face gay men and lesbians who experience rejection by their family for not being heterosexual. However, what constitutes rejection is not clear, and, more importantly, it is not known how resilience is fostered within such a context. This qualitative study sought to examine these issues by exploring the lived experiences of Australian gay men and lesbians who were previously or were currently experiencing family rejection because of their sexuality. A total of 21 in-depth, semistructured interviews were individually conducted and analyzed. Thematic analysis of the interviews revealed several themes that provided greater understanding of the portrayals and perceptions of family rejection; the impact of family rejection on mental health; and, importantly, how these individuals came to establish resilience in the face of experiencing family rejection. Limitations, directions for future research, and clinical implications of the findings are also discussed.

  8. Implicit versus Explicit Rejection Self-Perceptions and Adolescents' Interpersonal Functioning.

    Science.gov (United States)

    Mikami, Amori Yee; Schad, Megan M; Teachman, Bethany A; Chango, Joanna M; Allen, Joseph P

    2015-11-01

    We investigated associations between implicit and explicit self-perceptions of rejection with interpersonal functioning in close relationships. Adolescents (N=124) reported their explicit rejection self-perceptions on a questionnaire and completed the Implicit Association Test to assess their implicit rejection self-perceptions. After controlling for implicit self-perceptions, adolescents' explicit rejection self-perceptions were associated with the adolescents self-reporting more negative relationship quality with close friends and self-reporting more negative behaviors with romantic partners. After controlling for explicit self-perceptions, adolescents' implicit rejection self-perceptions were associated with their romantic partners reporting more negative relationship quality with them, and observations of adolescents displaying more negative behaviors with romantic partners. Implicit and explicit rejection self-perceptions uniquely explain individual differences in interpersonal behaviors.

  9. Implicit versus Explicit Rejection Self-Perceptions and Adolescents’ Interpersonal Functioning

    Science.gov (United States)

    Teachman, Bethany A.; Chango, Joanna M.; Allen, Joseph P.

    2015-01-01

    We investigated associations between implicit and explicit self-perceptions of rejection with interpersonal functioning in close relationships. Adolescents (N=124) reported their explicit rejection self-perceptions on a questionnaire and completed the Implicit Association Test to assess their implicit rejection self-perceptions. After controlling for implicit self-perceptions, adolescents’ explicit rejection self-perceptions were associated with the adolescents self-reporting more negative relationship quality with close friends and self-reporting more negative behaviors with romantic partners. After controlling for explicit self-perceptions, adolescents’ implicit rejection self-perceptions were associated with their romantic partners reporting more negative relationship quality with them, and observations of adolescents displaying more negative behaviors with romantic partners. Implicit and explicit rejection self-perceptions uniquely explain individual differences in interpersonal behaviors. PMID:26478646

  10. System for the Reduction of Substances in Reject Water from Reed-Bed Sludge Mineralization Plants

    DEFF Research Database (Denmark)

    2004-01-01

    The invention is a system for the reduction of substances in reject water from reed-bed sludge mineralization plants (also referred to as sludge dewatering reed-beds). The systems utilizes the composition of substances in reject water from reed-beds and that of sludge to reduce substance mass from...... within the container. The solution is then applied to the reed-beds, which dewaters, converts, and partially mineralize the sludge mixture. The reject water from the reed-beds is split where up to100% of the reject water is recirculated back to the mixed reactor and the remaining usually disposed...... the reject water via recirculation into a mixed reactor and back onto the reed-beds. The mixed rector consists of a container in which sludge (that is typically loaded directly on to reed-beds) is mixed with recirculated reject water from reed-beds. The sludge mixture has a definable hydraulic retention time...

  11. Analysis techniques for background rejection at the Majorana Demonstrator

    Energy Technology Data Exchange (ETDEWEB)

    Cuestra, Clara [University of Washington; Rielage, Keith Robert [Los Alamos National Laboratory; Elliott, Steven Ray [Los Alamos National Laboratory; Xu, Wenqin [Los Alamos National Laboratory; Goett, John Jerome III [Los Alamos National Laboratory

    2015-06-11

    The MAJORANA Collaboration is constructing the MAJORANA DEMONSTRATOR, an ultra-low background, 40-kg modular HPGe detector array to search for neutrinoless double beta decay in 76Ge. In view of the next generation of tonne-scale Ge-based 0νββ-decay searches that will probe the neutrino mass scale in the inverted-hierarchy region, a major goal of the MAJORANA DEMONSTRATOR is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. The background rejection techniques to be applied to the data include cuts based on data reduction, pulse shape analysis, event coincidences, and time correlations. The Point Contact design of the DEMONSTRATOR's germanium detectors allows for significant reduction of gamma background.

  12. Repair grinding -- An alternative to ultrasonic rejection for oilfield tubes

    Energy Technology Data Exchange (ETDEWEB)

    Stanley, R.K. (NDE Information Consultants, Houston, TX (United States))

    1994-10-01

    The price of scrap steel rose from $95 to $140/ton in 1993, making tubular production costs higher and making internal repair grinding of oil field tubes with minor internal surface breaking imperfections an extremely cost effective method for placing potentially reject tubulars back into service. Such imperfections often occur and are presently sized by the shear wave ultrasonic amplitude method. This article is written to illustrate how effective repair grinding can be in producing prime material within the API specifications 5CT, specification for Casing and Tubing; 5D, Specification for Drill Pipe; and 5L, Line Pipe. Ninety percent of high grade and 50--60% of midgrade materials can be saved by this method.

  13. Analysis techniques for background rejection at the MAJORANA DEMONSTRATOR

    Energy Technology Data Exchange (ETDEWEB)

    Cuesta, C.; Buuck, M.; Detwiler, J. A.; Gruszko, J.; Guinn, I. S.; Leon, J.; Robertson, R. G. H. [Center for Experimental Nuclear Physics and Astrophysics, and Department of Physics, University of Washington, Seattle, WA (United States); Abgrall, N.; Bradley, A. W.; Chan, Y-D.; Mertens, S.; Poon, A. W. P. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Arnquist, I. J.; Hoppe, E. W.; Kouzes, R. T.; LaFerriere, B. D.; Orrell, J. L. [Pacific Northwest National Laboratory, Richland, WA (United States); Avignone, F. T. [Department of Physics and Astronomy, University of South Carolina, Columbia, SC (United States); Oak Ridge National Laboratory, Oak Ridge, TN (United States); Baldenegro-Barrera, C. X.; Bertrand, F. E. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); and others

    2015-08-17

    The MAJORANA Collaboration is constructing the MAJORANA DEMONSTRATOR, an ultra-low background, 40- kg modular HPGe detector array to search for neutrinoless double beta decay in {sup 76}Ge. In view of the next generation of tonne-scale Ge-based 0νβ β-decay searches that will probe the neutrino mass scale in the inverted-hierarchy region, a major goal of the MAJORANA DEMONSTRATOR is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. The background rejection techniques to be applied to the data include cuts based on data reduction, pulse shape analysis, event coincidences, and time correlations. The Point Contact design of the DEMONSTRATOR’s germanium detectors allows for significant reduction of gamma background.

  14. Analysis techniques for background rejection at the MAJORANA DEMONSTRATOR

    CERN Document Server

    Cuesta, C; Arnquist, I J; Avignone, F T; Baldenegro-Barrera, C X; Barabash, A S; Bertrand, F E; Bradley, A W; Brudanin, V; Busch, M; Buuck, M; Byram, D; Caldwell, A S; Chan, Y-D; Christofferson, C D; Detwiler, J A; Efremenko, Yu; Ejiri, H; Elliott, S R; Galindo-Uribarri, A; Gilliss, T; Giovanetti, G K; Goett, J; Green, M P; Gruszko, J; Guinn, I S; Guiseppe, V E; Henning, R; Hoppe, E W; Howard, S; Howe, M A; Jasinski, B R; Keeter, K J; Kidd, M F; Konovalov, S I; Kouzes, R T; LaFerriere, B D; Leon, J; MacMullin, J; Martin, R D; Meijer, S J; Mertens, S; Orrell, J L; O'Shaughnessy, C; Poon, A W P; Radford, D C; Rager, J; Rielage, K; Robertson, R G H; Romero-Romero, E; Shanks, B; Shirchenko, M; Snyder, N; Suriano, A M; Tedeschi, D; Trimble, J E; Varner, R L; Vasilyev, S; Vetter, K; Vorren, K; White, B R; Wilkerson, J F; Wiseman, C; Xu, W; Yakushev, E; Yu, C -H; Yumatov, V; Zhitnikov, I

    2015-01-01

    The MAJORANA Collaboration is constructing the MAJORANA DEMONSTRATOR, an ultra-low background, 40-kg modular HPGe detector array to search for neutrinoless double beta decay in 76Ge. In view of the next generation of tonne-scale Ge-based 0nbb-decay searches that will probe the neutrino mass scale in the inverted-hierarchy region, a major goal of the MAJORANA DEMONSTRATOR is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. The background rejection techniques to be applied to the data include cuts based on data reduction, pulse shape analysis, event coincidences, and time correlations. The Point Contact design of the DEMONSTRATOR 0s germanium detectors allows for significant reduction of gamma background.

  15. Active disturbance rejection control in steering by wire haptic systems.

    Science.gov (United States)

    Rodriguez-Angeles, A; Garcia-Antonio, J A

    2014-07-01

    This paper introduces a steering by wired haptic system based on disturbance rejection control techniques. High gain Generalized Proportional Integral (GPI) observers are considered for the estimation of tire and steering wheel dynamic disturbances. These disturbances are on line canceled to ensure tracking between the commanded steering wheel angle and the tire orientation angle. The estimated disturbances at the steering rack are feedback to the steering wheel to provide a haptic interface with the driver. The overall system behaves as a bilateral master-slave system. Very few sensors and minimum knowledge of the dynamic model are required. Experimental results are presented on a prototype platform that consists on: (1) half of the steering rack of a beetle VW vehicle, (2) a steering wheel.

  16. Antibody-Mediated Rejection: An Evolving Entity in Heart Transplantation

    Directory of Open Access Journals (Sweden)

    Sharon Chih

    2012-01-01

    Full Text Available Antibody-mediated rejection (AMR is gaining increasing recognition as a major complication after heart transplantation, posing a significant risk for allograft failure, cardiac allograft vasculopathy, and poor survival. AMR results from activation of the humoral immune arm and the production of donor-specific antibodies (DSA that bind to the cardiac allograft causing myocardial injury predominantly through complement activation. The diagnosis of AMR has evolved from a clinical diagnosis involving allograft dysfunction and the presence of DSA to a primarily pathologic diagnosis based on histopathology and immunopathology. Treatment for AMR is multifaceted, targeting inhibition of the humoral immune system at different levels with emerging agents including proteasome and complement inhibitors showing particular promise. While there have been significant advances in our current understanding of the pathogenesis, diagnosis, and treatment of AMR, further research is required to determine optimal diagnostic tools, therapeutic agents, and timing of treatment.

  17. The Complement System and Antibody-Mediated Transplant Rejection.

    Science.gov (United States)

    Stites, Erik; Le Quintrec, Moglie; Thurman, Joshua M

    2015-12-15

    Complement activation is an important cause of tissue injury in patients with Ab-mediated rejection (AMR) of transplanted organs. Complement activation triggers a strong inflammatory response, and it also generates tissue-bound and soluble fragments that are clinically useful markers of inflammation. The detection of complement proteins deposited within transplanted tissues has become an indispensible biomarker of AMR, and several assays have recently been developed to measure complement activation by Abs reactive to specific donor HLA expressed within the transplant. Complement inhibitors have entered clinical use and have shown efficacy for the treatment of AMR. New methods of detecting complement activation within transplanted organs will improve our ability to diagnose and monitor AMR, and they will also help guide the use of complement inhibitory drugs.

  18. Background rejection in dilepton analysis with CBM-MVD

    Energy Technology Data Exchange (ETDEWEB)

    Krebs, Erik [Goethe-Universitaet Frankfurt am Main (Germany); Collaboration: CBM-MVD-Collaboration

    2015-07-01

    The light vector mesons ρ, ω and φ are known to be excellent probes of the strongly interacting matter under extreme conditions. The leptonic decay channels of these mesons are of special interest as the leptons leave the hot and dense fireball without strong interaction and may reveal information on the characteristics of the matter created in the collisions. However, electrons and positrons from γ-conversions and Dalitz decays of π{sup 0} are the main contributors to a large combinatorial background obscuring the information carried by the rare dileptons. The Micro-Vertex Detector (MVD) of the Compressed Baryonic Matter (CBM) experiment can contribute to reduce this background by reconstructing the low momentum partner of background pair in the MVD. CBM has no detectors for electron identification in front of the magnetic field posing an additional challenge to dielectron analysis. Methods for background rejection are presented.

  19. Adaptive actuator failure compensation and disturbance rejection scheme for spacecraft

    Institute of Scientific and Technical Information of China (English)

    Xuelian Yao; Gang Tao; Ruiyun Qi

    2014-01-01

    An adaptive actuator failure compensation scheme is proposed for attitude tracking control of spacecraft with unknown disturbances and uncertain actuator failures. A new feature of this adaptive control scheme is the adaptation of the failure pattern parameter estimates, as wel as the failure signal parameter es-timates, for direct adaptive actuator failure compensation. Based on an adaptive backstepping control design, the estimates of the disturbance parameters are used to solve the disturbance rejection problem. The unknown disturbances are compensated completely with the stability of the whole closed-loop system. The scheme is not only able to accommodate uncertain actuator failures, but also robust against unknown external disturbances. Simulation results verify the desired adaptive actuator failure compensation perfor-mance.

  20. The School Violence Between Peers in Popular and Rejected Students

    Directory of Open Access Journals (Sweden)

    Teresa I. Jiménez Gutiérrez

    2011-12-01

    Full Text Available Psychosocial models of adolescent development have pointed to the importance of considering the interrelationship between relevant contexts (family, school and community in understanding psychosocial adjustment. However, few studies have examined the combined influence of these contexts in the development of specific behavioral problems such as violent behavior in schools. The present study aims to explore the links between the perception of the family, school and community climate on school violence considering the role of subjective well-being and adolescent distress. To test these multiple relationships a sample of 1795 adolescents of both sexes aged between 11 and 18 has been used. Data were analyzed using a structural equation model, including a multi-group analysis for popular and rejected students in the classroom. The results support the expected relationships and the resulting model is equivalent for both sociometric status. The discussion considers the implications of these findings for intervention with adolescents from an individual and contextual perspective.

  1. European consumers' acceptance and rejection of novel beef technologies

    DEFF Research Database (Denmark)

    de Barcellos, Marcia Dutra; Kügler, Jens Oliver; Grunert, Klaus G.

    As part of ProSafeBeef, an integrated research project funded by the European Commission, the present qualitative study was carried out with European consumers to obtain insights into their acceptance or rejection of eight selected novel beef production and processing technologies, identified here...... as concepts: 1) marinating by injection for increased healthiness; 2) marinating by injection for increased safety; 3) marinating by injection for increased eating quality; 4) marinating by submerging for increased eating quality; 5) nutritional enhancement; 6) shock wave treatment; 7) muscle profiling and 8...... of each one of them. The obtained data was consecutively transcribed, coded and analysed by using the software package NVivo 7. The results reveal a dependency between the acceptance of novel beef products and how consumers perceive the characteristics of the innovation itself. Excess manipulation...

  2. European consumers' acceptance and rejection of novel beef technologies

    DEFF Research Database (Denmark)

    de Barcellos, Marcia Dutra; Kügler, Jens Oliver; Grunert, Klaus G.

    as concepts: 1) marinating by injection for increased healthiness; 2) marinating by injection for increased safety; 3) marinating by injection for increased eating quality; 4) marinating by submerging for increased eating quality; 5) nutritional enhancement; 6) shock wave treatment; 7) muscle profiling and 8...... capital cities: Madrid, Paris, Berlin and London. A common and translated topic guide was developed prior to the field work. A ranking exercise was applied, where the participants classified the technologies into accepted, neutral or rejected concepts, after discussing the perceived benefits and risks...... are less demanding in terms of beef quality and have less culinary skills. However, consumers support the development of technologies that can provide more healthiness and better eating quality, and if such technologies are 'not invasive', the chances to be accepted increase. Current trends and development...

  3. Family and community rejection and a Congolese led mediation intervention to reintegrate rejected survivors of sexual violence in Eastern Democratic Republic of Congo.

    Science.gov (United States)

    Kohli, Anjalee; Tosha, Maphie; Ramazani, Paul; Safari, Octave; Bachunguye, Richard; Zahiga, Isaya; Iragi, Aline; Glass, Nancy

    2013-01-01

    Our purpose in this study is to describe the multiple and inter-related health, economic, and social reasons for rejection and to provide an example of a Congolese-led family mediation program to reintegrate survivors into their families. We conducted this study in Eastern Democratic Republic of Congo (DRC) and included two focus group discussions and twenty-seven interviews. Rejection extends beyond physical dislocation to include economic and social aspects. Family mediation is a process requiring knowledge of traditions and norms. Understanding the context of rejection and supporting promising local reintegration efforts will likely improve health, economic, and social outcomes for the survivor, her family, and her community.

  4. HOS AND GA BASED INTERFERENCE REJECTION IN DIRECT SEQUENCE SPREAD SPECTRUM COMMUNICATION SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Gong Xiangyang; Hu Guangrui; Li Taijie

    2003-01-01

    A new Higher Order Statistics (HOS) and Genetic Algorithm (GA)-based interference rejection filter is introduced. Compared with the adaptive filters based on second-order statistics and gradient algorithm, the HOS and GA-based filter can reject the interference more efficiently, is independent of uncorrelated Gaussian noise, tends to converge to the optimum solution and is much less sensitive to the choice of the step size parameter. Computer simulations show that the method can reject narrowband interference efficiently.

  5. ON-LINE SCHEDULING OF UNIT TIME JOBS WITH REJECTION ON UNIFORM MACHINES

    Institute of Scientific and Technical Information of China (English)

    Shoupeng LIU; Yuzhong ZHANG

    2008-01-01

    The authors consider the problem of on-line scheduling of unit execution time jobs on uniform machines with rejection penalty. The jobs arrive one by one and can be either accepted and scheduled, or be rejected. The objective is to minimize the total completion time of the accepted jobs and the total penalty of the rejection jobs. The authors propose an on-line algorithm and prove that the competitive ratio is 1/2 (2 + ) ≈ 1.86602.

  6. A Network-Centric Formalism for Disturbance Rejection Design and Human Swarm Interaction

    Science.gov (United States)

    2015-07-06

    AFRL-AFOSR-VA-TR-2016-0007 Formalism for Disturbance Rejection Design and Human- swarm Interaction Mehran Mesbahi UNIVERSITY OF WASHINGTON Final...SUBTITLE A Network-centric Formalism for Disturbance Rejection Design and Human Swarm Interaction 5a. CONTRACT NUMBER FA9550-12-1-0203 5b. GRANT NUMBER...proposed research is to examine fundamental structural bounds on the disturbance rejection and human- swarm interaction properties of a network of

  7. Linear Active Disturbance Rejection Control for LCL Type Grid-connected Converter

    OpenAIRE

    Lu, Jinghang; Savaghebi, Mehdi; Josep M. Guerrero; Quintero, Juan Carlos Vasquez; Xie, Chuan

    2016-01-01

    This paper presents a linear active disturbance rejection control (LADRC) for grid-connected converter with LCL filter. The high rejection performance for external disturbance, internal decoupling, parameter variation is achieved by adopting extended state observer(ESO) and designing controller with direct pole placement. Robustness of parameteruncertainty and sensitivity of input disturbance are analyzed in frequency domain to demonstrate the superior characteristic in disturbance rejection....

  8. Self-compassion and forgiveness: The protective approach against rejection sensitivity

    OpenAIRE

    SAKIZ, Halis; Hakan SARIÇAM

    2015-01-01

    The main purpose of this study was to examine the relationship between self-compassion, forgiveness and rejection sensitivity. Participants were 496 university students who completed the Self-compassion Scale, the Trait Forgiveness Scale and the Rejection Sensitivity Questionnaire. The obtained data were analyzed with Pearson Moments Correlation Analysis and Multiple Regression Analysis (MRA). In correlation analysis, forgiveness and self-compassion were negatively related to rejection sensit...

  9. Changing Paradigms in the Management of Rejection in Kidney Transplantation

    Science.gov (United States)

    Maier, Mirela; Takano, Tomoko; Sapir-Pichhadze, Ruth

    2017-01-01

    Purpose of review: P4 medicine denotes an evolving field of medicine encompassing predictive, preventive, personalized, and participatory medicine. Using the example of kidney allograft rejection because of donor-recipient incompatibility in human leukocyte antigens, this review outlines P4 medicine’s relevance to the various stages of the kidney transplant cycle. Sources of information: A search for English articles was conducted in Medline via OvidSP (up to August 18, 2016) using a combination of subject headings (MeSH) and free text in titles, abstracts, and author keywords for the concepts kidney transplantation and P4 medicine. The electronic database search was expanded further on particular subject headings. Findings: Available histocompatibility methods exemplify current applications of the predictive and preventive domains of P4 medicine in kidney transplant recipients’ care. Pharmacogenomics are discussed as means to facilitate personalized immunosuppression regimens and promotion of active patient participation as a means to improve adherence. Limitations: For simplicity, this review focuses on rejection. P4 medicine, however, should more broadly address health concerns in kidney transplant recipients, including competing outcomes such as infections, malignancies, and cardiovascular disease. This review highlights how biomarkers to evaluate these competing outcomes warrant validation and standardization prior to their incorporation into clinical practice. Implications: Consideration of all 4 domains of the P4 medicine framework when caring for and/or studying kidney transplant recipients has the potential of increasing therapeutic efficiency, minimizing adverse effects, decreasing health care costs, and maximizing wellness. Technologies to gauge immune competency, immunosuppression requirements, and early/reversible immune-mediated injuries are required to optimize kidney transplant care. PMID:28270929

  10. Injury-induced allograft rejection: A rendezvous with evolution.

    Science.gov (United States)

    Land, Walter G

    2013-01-01

    Modern immunology, in many ways, is based on three major paradigms: the clonal selection theory, the pattern recognition theory, and the danger/injury theory. The last theory holds that any cell stress and tissue injury, including allograft injury, via induction of damage-associated molecular patterns, induces immunity, including alloimmunity, leading to allograft rejection. On the other hand, the concept precludes that non-self per se induces immunity as proposed by the two former theories. Recently, the danger/injury model has gained considerable acceptance by immunologists, in particular as promoted by new insights into the function of the mammalian gut microbiota, representing a huge assemblage of non-self. Harboring microbiota by hosts is characterized by the fact that harmless noninjurious commensal microbes are protected by innate immunity-based tolerance, whereas intestinal injury-causing pathogenic microbes are immunologically attacked. Plausibility and validity of the danger/injury concept is stringently supported by observations of similar phenomena across the tree of life: the ability of the immune system to discriminate between harmful life-threatening non-self to induce immunity and harmless beneficial non-self to induce tolerance has apparently emerged during evolution. Immune defense responses to injuring/injured non-self (e.g., as reflected by plant resistance to biotic and abiotic stresses on one hand, and allograft rejection on the other hand) as well as immunity-controlled protection of beneficial non-self (e.g., as reflected by microbiota and the fetus of placental mammals) are processes in the interest of evolution and, thus, evolved under pressure across the phylogenetic tree.

  11. Adaptive filtering for ECG rejection from surface EMG recordings.

    Science.gov (United States)

    Marque, C; Bisch, C; Dantas, R; Elayoubi, S; Brosse, V; Pérot, C

    2005-06-01

    Surface electromyograms (EMG) of back muscles are often corrupted by electrocardiogram (ECG) signals. This noise in the EMG signals does not allow to appreciate correctly the spectral content of the EMG signals and to follow its evolution during, for example, a fatigue process. Several methods have been proposed to reject the ECG noise from EMG recordings, but seldom taking into account the eventual changes in ECG characteristics during the experiment. In this paper we propose an adaptive filtering algorithm specifically developed for the rejection of the electrocardiogram corrupting surface electromyograms (SEMG). The first step of the study was to choose the ECG electrode position in order to record the ECG with a shape similar to that found in the noised SEMGs. Then, the efficiency of different algorithms were tested on 28 erector spinae SEMG recordings. The best algorithm belongs to the fast recursive least square family (FRLS). More precisely, the best results were obtained with the simplified formulation of a FRLS algorithm. As an application of the adaptive filtering, the paper compares the evolutions of spectral parameters of noised or denoised (after adaptive filtering) surface EMGs recorded on erector spinae muscles during a trunk extension. The fatigue test was analyzed on 16 EMG recordings. After adaptive filtering, mean initial values of energy and of mean power frequency (MPF) were significantly lower and higher respectively. The differences corresponded to the removal of the ECG components. Furthermore, classical fatigue criteria (increase in energy and decrease in MPF values over time during the fatigue test) were better observed on the denoised EMGs. The mean values of the slopes of the energy-time and MPF-time linear relationships differed significantly when established before and after adaptive filtering. These results account for the efficacy of the adaptive filtering method proposed here to denoise electrophysiological signals.

  12. IMC based robust PID controller tuning for disturbance rejection

    Institute of Scientific and Technical Information of China (English)

    Mohammad Shamsuzzoha

    2016-01-01

    It is well-known that the IMC-PID controller tuning gives fast and improved set point response but slow disturbance rejection. A modification has been proposed in IMC-PID tuning rule for the improved disturbance rejection. For the modified IMC-PID tuning rule, a method has been developed to obtain the IMC-PID setting in closed-loop mode without acquiring detailed information of the process. The proposed method is based on the closed-loop step set point experiment using a proportional only controller with gainKc0. It is the direct approach to find the PID controller setting similar to classical Ziegler-Nichols closed-loop method. Based on simulations of a wide range of first-order with delay processes, a simple correlation has been derived to obtain the modified IMC-PID controller settings from closed-loop experiment. In this method, controller gain is a function of the overshoot obtained in the closed loop set point experiment. The integral and derivative time is mainly a function of the time to reach the first peak (overshoot). Simulation has been conducted for the broad class of processes and the controllers were tuned to have the same degree of robustness by measuring the maximum sensitivity, Ms, in order to obtain a reasonable comparison. The PID controller settings obtained in the proposed tuning method show better performance and robustness with other two-step tuning methods for the broad class of processes. It has also been applied to temperature control loop in distillation column model. The result has been compared to the open loop tuning method where it gives robust and fast response.

  13. Rejection Thresholds in Chocolate Milk: Evidence for Segmentation

    Science.gov (United States)

    Harwood, Meriel L.; Ziegler, Gregory R.; Hayes, John E.

    2012-01-01

    Bitterness is generally considered a negative attribute in food, yet many individuals enjoy some bitterness in products like coffee or chocolate. In chocolate, bitterness arises from naturally occurring alkaloids and phenolics found in cacao. Fermentation and roasting help develop typical chocolate flavor and reduce the intense bitterness of raw cacao by modifying these bitter compounds. As it becomes increasingly common to fortify chocolate with `raw' cacao to increase the amount of healthful phytonutrients, it is important to identify the point at which the concentration of bitter compounds becomes objectionable, even to those who enjoy some bitterness. Classical threshold methods focus on the presence or absence of a sensation rather than acceptability or hedonics. A new alternative, the rejection threshold, was recently described in the literature. Here, we sought to quantify and compare differences in Rejection Thresholds (RjT) and Detection Thresholds (DT) in chocolate milk spiked with a food safe bitterant (sucrose octaacetate). In experiment 1, a series of paired preference tests was used to estimate the RjT for bitterness in chocolate milk. In a new group of participants (experiment 2), we determined the RjT and DT using the forced choice ascending method of limits. In both studies, participants were segmented on the basis of self-declared preference for milk or dark solid chocolate. Based on sigmoid fits of the indifference-preference function, the RjT was ~2.3 times higher for those preferring dark chocolate than the RjT for those preferring milk chocolate in both experiments. In contrast, the DT for both groups was functionally identical, suggesting that differential effects of bitterness on liking of chocolate products are not based on the ability to detect bitterness in these products. PMID:22754143

  14. La calidad de las evaluaciones de manuscritos en Gaceta Sanitaria Quality of manuscript evaluation in Gaceta Sanitaria

    Directory of Open Access Journals (Sweden)

    A.M. García

    2002-06-01

    conjunto.Objective: To describe strengths and weaknesses of peer reviews of manuscripts received in Gaceta Sanitaria in order to guide reviewers selection, to improve quality of peer reviews and to establish an internal system to be incorporated to the editorial process of handling manuscripts. Methods: 100 peer reviews of 55 manuscripts received during 2000 and 2001 were included. A questionnaire containing closed questions assessing specific and general components of reviews' quality was applied (answers Yes/No or on a 5-points scale. Descriptive and correlation analyses were performed for the different items in the questionnaire. An Index of Quality was obtained by adding the ratings on the items in the questionnaire measuring specific quality components. Results: Peer reviews were rated high regarding completeness of the forms for reviewers (84%, constructiveness of the comments (reviews over 3: 63%, identification of the strengths and weaknesses of the method (reviews over 3: 59% and substantiation of the reviewer comments (reviews over 3: 58%. Assessment of the manuscript's relevance (reviews over 3: 40% or originality (reviews over 3: 35% were less frequent. Conclusions: Quality of peer reviews in Gaceta Sanitaria is good. Some weaknesses in the reviews have been pointed out. It is possible to establish a systematic process for assessing peer reviewers using simple indicators such as general utility of the review for the editorial decision and general quality of the review.

  15. Spanish Mystic Women of the Golden Century within the Ottoman Empire: Seven Arabic Manuscripts Found in Aleppo (Syria

    Directory of Open Access Journals (Sweden)

    Francisco Fernando del Río Sánchez

    2015-05-01

    Full Text Available This work reports on the existence of seven manuscripts conserved in three different collections of Aleppo (Syria: the Greek-Catholic/Melkite, the Georges and Mathilde Salem Foundation and the Maronite libraries. These seven co­pies contain the Arabic translations of some mystical works written by two mystic women of the Spanish Golden Century, Teresa de Ávila and María de Ágreda. The history of these Arabic versions, translated right in the heart of the Ottoman Arabic provinces, constitutes an interesting object of study that is directly linked with the manner in which many  European Western works passed to the Mediterranean Levant during the 16th and 17th centuries.

  16. Survey of editors and reviewers of high-impact psychology journals: statistical and research design problems in submitted manuscripts.

    Science.gov (United States)

    Harris, Alex; Reeder, Rachelle; Hyun, Jenny

    2011-01-01

    The authors surveyed 21 editors and reviewers from major psychology journals to identify and describe the statistical and design errors they encounter most often and to get their advice regarding prevention of these problems. Content analysis of the text responses revealed themes in 3 major areas: (a) problems with research design and reporting (e.g., lack of an a priori power analysis, lack of congruence between research questions and study design/analysis, failure to adequately describe statistical procedures); (b) inappropriate data analysis (e.g., improper use of analysis of variance, too many statistical tests without adjustments, inadequate strategy for addressing missing data); and (c) misinterpretation of results. If researchers attended to these common methodological and analytic issues, the scientific quality of manuscripts submitted to high-impact psychology journals might be significantly improved.

  17. [Textual research on Han-Chinese formulae collected in Tubo medical manuscript unearthed in 'Bum-pa-Che Tower].

    Science.gov (United States)

    Liu, Y H; Nong, H C

    2016-11-28

    A Tibetan manuscript with title of Sman-dpyad gces-pa grub-pa kun-'dus-pa in the Collection of Practiced Medical Quintessence, was found in the basement of a Buddhist tower named 'Bum-pa-che in Lhokha (Shannan), Tibet. It contains a purgative recipe of TCM with its title "Powder of Han Region" and several ingredients in Chinese transliteration. Based upon the rule of medieval Chinese system of pronunciation with reference of related texts and studies, a textual research identifies it as a kind of Maren (seed of Cannabis sativa L. ) wan in TCM. Although no identical formulae of its kind has been found in extant literature of TCM prior to the Song Dynasty(960 AD), yet its ingredients, pharmaceutical preparation and efficacy are very similar to the Modified maren wan, the variant formulae of Maren wan in Wai tai mi yao (Arcane Essentials from the Imperial Library) of the Tang Dynasty.

  18. Gay-Related Rejection Sensitivity as a Risk Factor for Condomless Sex.

    Science.gov (United States)

    Wang, Katie; Pachankis, John E

    2016-04-01

    Gay-related rejection sensitivity has been linked to numerous adverse health outcomes, but its relationship to condomless sex remains unexamined. The present study investigated the role of gay-related rejection sensitivity as a predictor of condomless sex. Gay and bisexual men completed questionnaires measuring rejection sensitivity and condom use self-efficacy as well as a timeline followback interview regarding past 90-day sexual behaviors. Gay-related rejection sensitivity was positively associated with the number of condomless anal sex acts with casual partners, and condom use self-efficacy mediated this association. These findings have important implications for effective HIV prevention efforts among this at-risk population.

  19. Examining ethnic differences in parental rejection of LGB youth sexual identity.

    Science.gov (United States)

    Richter, Brian E J; Lindahl, Kristin M; Malik, Neena M

    2017-03-01

    Upward of 70% of lesbian, gay, and bisexual (LGB) youth experience some degree of parental rejection of their sexual identity, which is problematic in light of research documenting links between parental rejection and psychological difficulties in LGB youth. Additionally, emerging research suggests that ethnic minority LGB youth may be at greater risk to experience parental rejection than ethnic majority LGB youth. However, this research is inconclusive and has significant gaps. The current study is one of the first to include a multiethnic sample of LGB youth and their parents to investigate how ethnicity may be related to parental rejection. Specifically, the current study examined ethnic differences in parental rejection as well as in intrapersonal variables (i.e., homonegativity and traditional gender role beliefs), which are thought to be related both to ethnicity and parental rejection. Additionally, indirect effects of ethnicity on parental rejection through homonegativity and traditional gender role beliefs were examined. Participants included 90 parents (ages 32-63) and their 90 LGB children (ages 15-24). Fifty-nine percent of the sample were ethnic minority. Significant ethnic differences were found in parental rejection and homonegativity, but not in traditional gender role beliefs. Homonegativity was found to fully mediate the relation between ethnicity and parental rejection. These results provide important information on why ethnic minority parents, in general, may have a more difficult time accepting their LGB children than ethnic majority parents. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  20. Improved High-Rejection Filters and MEMS-Enabled Smart Reconfigurable Antennas Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Proposed work envisions development of high-rejection filters and smart reconfigurable antennas using MEMS switches. Adaptive feature of the proposed antenna...

  1. B-splines smoothed rejection sampling method and its applications in quasi-Monte Carlo integration

    Institute of Scientific and Technical Information of China (English)

    雷桂媛

    2002-01-01

    The rejection sampling method is one of the most popular methods used in Monte Carlo methods. It turns out that the standard rejection method is closely related to the problem of quasi-Monte Carlo integration of characteristic functions, whose accuracy may be lost due to the discontinuity of the characteristic functions. We proposed a B-splines smoothed rejection sampling method, which smoothed the characteristic function by B-splines smoothing technique without changing the integral quantity. Numerical experiments showed that the convergence rate of nearly O(N-1) is regained by using the B-splines smoothed rejection method in importance sampling.

  2. B-splines smoothed rejection sampling method and its applications in quasi-Monte Carlo integration

    Institute of Scientific and Technical Information of China (English)

    雷桂媛

    2002-01-01

    The rejection sampling method is one of the most popular methods used in Monte Carlo methods. It turns out that the standard rejection method is closely related to the problem of quasi-Monte Carlo integration of characteristic functions, whose accuracy may be lost due to the discontinuity of the characteristic functions. We proposed a B-splines smoothed rejection sampling method, which smoothed the characteristic function by B-splines smoothing technique without changing the integral quantity. Numerical experiments showed that the convergence rate of nearly O( N-1 ) is regained by using the B-splines smoothed rejection method in importance sampling.

  3. The Characteristics of Acute Rejection after Limb Allotransplantation in Rats-An Experimental Study

    Institute of Scientific and Technical Information of China (English)

    康皓; 洪光祥; 王发斌; 陈振兵; 黄启顺; 翁雨雄

    2003-01-01

    To study the characteristics of acute rejection after limb allotransplantation, 29 male Sprague-Dawley rats were randomly divided into 2 groups, with 15 rats in control group and 14 rats in experimental group. Each rat in control group underwent limb replantation. Each rat in experimental group received limb transplantation from Wistar rat. No immnosuppressive drugs were used after operation. The circulation of the transplanted limb, time and signs of rejection, histopathological changes in the tissues of the limb graft when rejected and survival time of limb grafts were evaluated. In the control group, no signs of rejection were observed, the circulation of each replanted limb was normal, it could survive for a longer time. The experimental group showed clinical signs of rejection (sub dermal edema and erythema) after a mean time of 3. 36±1.15 days, and the mean survival time of the allografts was only 7±0.78 days. Histopathological examination showed most violent rejection reaction in skin. It is concluded that with Wistar-to-SD limb transplantation without use of immunosuppression, rejection of the grafts would occur after a mean time of 3.36 ±1.15days; the earliest signs of rejection were edema and erythema of the skin, skin being the most representative component of limb graft rejection.

  4. [Lymphoid neogenesis and lymphangiogenesis: two newcomers in the pathophysiology of chronic rejection].

    Science.gov (United States)

    Attuil-Audenis, Valérie; Duthey, Aurélie; Patey, Natacha; Gautreau, Chantal; McGregor, Brigitte; Morelon, Emmanuel; Michel, Jean-Baptiste; Nicoletti, Antonino; Thaunat, Olivier

    2009-04-01

    Chronic rejection is one of the main causes of late allograft failure and no therapy is currently available to prevent efficiently its development. Improving the comprehension of the mechanisms involved in the pathophysiology of chronic rejection is a mandatory step to propose innovative therapies that would prolong grafts' survival. Using the rat aortic interposition model of chronic vascular rejection, we have demonstrated that the intragraft inflammatory infiltrate progressively organized itself into a functional ectopic lymphoid tissue (tertiary lymphoid organ) supporting the local synthesis of alloantibody. Thus, during chronic rejection the graft is at the same time the target and the site of elaboration of the humoral allo-immune response. This hypothesis has been confirmed in the clinical setting by the analysis of human grafts (kidneys, hearts and lungs) removed for terminal failure due to chronic rejection. This lymphoid neogenesis process, previously identified in other chronic inflammatory diseases, occurs with a strikingly high frequency in chronically rejected grafts, suggesting that an additional mechanism synergizes to initiate the development of tertiary lymphoid organs during chronic rejection. We propose that the defective lymphatic drainage of chronically rejected organs triggers lymphoid neogenesis and we discuss the complex crosstalk between lymphoid neogenesis and lymphangiogenesis that takes place during chronic rejection.

  5. Egg rejection behavior in a population exposed to parasitism: Village Weavers on Hispaniola

    Science.gov (United States)

    Cruz, A.; Prather, J.W.; Wiley, J.W.; Weaver, P.F.

    2008-01-01

    In contrast to African Village Weavers (Ploceus cucullatus) that are parasitized by Diederik Cuckoos (Chrysococcyx caprius), introduced weavers on Hispaniola existed without parasitism for at least 2 centuries until the arrival of the Shiny Cowbird (Molothrus bonariensis) in the 1970s. Cruz and Wiley (1989) found that Hispaniolan weavers had a lower rejection rate of foreign eggs than African populations. Subsequently, Robert and Sorci (1999) and Lahti (2005, 2006) found that acceptance of dissimilar eggs is not characteristic of the species throughout its Hispaniolan range. In 1999-2002, we studied egg rejection in Hispaniolan weavers on a broad regional scale. Rejection increased as experimental eggs became increasingly different from the host eggs. Rejection rates for mimetic eggs, different color eggs, different-spotting eggs, and cowbird eggs was 23.2%, 33.3%, 61.5%, and 85.3%, respectively, with higher rejection of cowbird eggs in areas where cowbirds were observed. Although rejection is likely to have a genetic component, the differences could be due to phenotypic plasticity. Plasticity in egg rejection may be expected, given the potential cost of rejection and the spatiotemporal distribution of cowbirds. Thus, egg rejection has not necessarily decreased in Hispaniolan weavers, but it may act in a plastic manner, increasing where cowbirds are present. ?? The Author 2008. Published by Oxford University Press on behalf of the International Society for Behavioral Ecology. All rights reserved.

  6. Film reject analysis and image quality in diagnostic Radiology Department of a Teaching hospital in Ghana

    Directory of Open Access Journals (Sweden)

    J. Owusu-Banahene

    2014-10-01

    Full Text Available Patients usually undergo repeated X-ray examinations after their initial X-ray radiographs are rejected due to poor image quality. This subjects the patients to an excess radiation exposure and extra cost and necessitates the need to investigate the causes of reject. The use of reject analysis as part of the overall quality assurance programs in clinical radiography and radiology services is vital in the evaluation of image quality of a well-established practice. It is shown that, in spite of good quality control maintained by the Radiology Department of a Teaching hospital in Ghana, reject analysis performed on a number of radiographic films developed indicated 14.1% reject rate against 85.9% accepted films. The highest reject rate was 57.1 ± 0.7% which occurs in cervical spine and the lowest was7.7 ± 0.5% for lumbar spine. The major factors contributing to film rejection were found to be over exposure and patient positioning in cervical spine examinations. The most frequent examination was chest X-ray which accounts for about 42.2% of the total examinations. The results show low reject rates by considering the factors for radiographic rejection analysis in relation to both equipment functionality and film development in the facility.

  7. Border Structures in Arthurian Manuscript BNF, fr. 95 as an Expression of the Artist’s mente propria

    Directory of Open Access Journals (Sweden)

    Miha Zor

    2014-12-01

    Full Text Available The paper analyses the stylistic and compositional characteristics of borders in a manuscript consisting of the first two romances of the Lancelot-Graal Cycle (Estoire del saint Graal, Merlin with Suite Vulgate and two non-Arthurian texts (Le Roman de sept sages, Pénitence Adam. Two different types of borders are present, and in the article they are named type A and type B. They were employed with regard to the position of the miniature in the page: where the miniature appears in the left column, type A was used, and where it appears in the right column, type B was employed. The borders of type A embrace the text from three sides: the vertical border runs along the left column, and both horizontal ones spread over the space of both textual columns. In the case of type B, the vertical border runs along the right side of the right column, that is between the two columns, but closer to the right one; on the top and bottom, horizontal borders spring from the centre to both sides (over both columns. Certain compositions make it possible to assume that the main illuminator or the planner of the overall appearance of the manuscript was actively present also as far as the borders are concerned. Other details – e.g. gold background when two figures form contact with their bodies, and the lack of such a background, when they do not touch or touch only with their weapons – may testify to a personal intervention of the practising artist, and this may be characterized as a stylistic trait revealing his mente propria.

  8. Apheresis research-more abstracts should be published as full manuscripts to provide more evidence for clinical practice guidelines.

    Science.gov (United States)

    Pham, Huy P; Jiang, Ning; Pan, Zhi; Williams, Lance A; Marques, Marisa B

    2016-08-01

    High-quality evidence to support clinical practice is lacking in apheresis medicine compared to other therapeutic modalities. A potential source of evidence comes from the abstracts submitted to the Annual Meetings of the American Society for Apheresis (ASFA). Therefore, the goal of this study is to determine the proportion of abstracts from the 2005 to 2012 ASFA Annual Meetings that subsequently became PubMed-indexed publications. Furthermore, we sought to determine the factor(s) that were associated with the likelihood of abstracts to be published as full manuscripts. During the 8-year study period, 684 abstracts were available for analysis (median: 82/year, range: 64-118). Most abstracts (74%) were from US institutions, and 67% of first authors were affiliated with academic centers. There were more abstracts (64%) on therapeutic versus donor apheresis (20%) and cellular therapy (16%). Overall, 16% of the abstracts have been published in PubMed-indexed journals, with a median time of 17 months from the ASFA Annual Meeting (range: 1-96 months). Abstracts whose first authors were affiliated with academic institutions were 3.14 times more likely to have been published than abstracts with ones affiliated with an apheresis organization and/or a community hospital. However, neither the first author's location nor the type of apheresis procedure significantly affected the publication rate after adjusting for other covariates. In conclusion, the rate of publication is low and authors should be encouraged to follow their presentations at the meeting with peer-reviewed manuscripts. This change is essential to provide more published evidence for future apheresis practice guidelines. J. Clin. Apheresis 31:353-358, 2016. © 2015 Wiley Periodicals, Inc.

  9. The role of the graft endothelium in transplant rejection: evidence that endothelial activation may serve as a clinical marker for the development of chronic rejection.

    Science.gov (United States)

    Denton, M D; Davis, S F; Baum, M A; Melter, M; Reinders, M E; Exeni, A; Samsonov, D V; Fang, J; Ganz, P; Briscoe, D M

    2000-11-01

    In this review, we discuss the role of the allograft endothelium in the recruitment and activation of leukocytes during acute and chronic rejection. We discuss associations among endothelial activation responses, the expression of adhesion molecules, chemokines and chemokine receptors, and rejection; and we propose that endothelial vascular cellular adhesion molecule-1 (VCAM-1) may be used as a surrogate marker of acute rejection and allograft vasculopathy. In addition, we describe potential mechanistic interpretations of persistent endothelial cell (EC) expression of major histocompatibility complex (MHC) class II molecules in allorecognition. The graft endothelium may provide an antigen-specific signal to transmigrating, previously activated, T cells and may induce B7 expression on locally transmigrating leukocytes to promote costimulation. Taken together, these functions of the EC provide it with a potent regulatory role in rejection and in the maintenance of T-cell activation via the direct and/or the indirect pathways of allorecognition.

  10. The purple Codex Rossanensis: spectroscopic characterization and first evidence of the use of the elderberry lake in a 6th century manuscript

    CERN Document Server

    Bicchieri, Marina

    2014-01-01

    The Codex Rossanensis is a 6th century Bizantine illuminated manuscript written on purple parchment and conserved at the Museo Diocesano in Rossano Calabro, Italy. It is one of the oldest surviving illuminated manuscripts of the New Testament. The challenge of the analysis of the Codex Rossanensis lies in the lack of analytical information on the pictorial media used in the Early Middle Ages. Even though old-medieval illuminated manuscripts have been deeply studied from the historical standpoint, they have been rarely described in their material composition. This paper presents the results obtained during the measurements campaign (June 2012 - November 2013). The spectroscopic analyses performed by Raman, micro-FTIR and XRF allowed for the complete characterization of the pictorial palette, the inks, the support and the material used in a previous restoration treatment. To the author knowledge the article shows the first experimental evidence of the usage of the elderberry lake in a 6th century illuminated ma...

  11. A Channel Rejection Method for Attenuating Motion-Related Artifacts in EEG Recordings during Walking.

    Science.gov (United States)

    Oliveira, Anderson S; Schlink, Bryan R; Hairston, W David; König, Peter; Ferris, Daniel P

    2017-01-01

    Recording scalp electroencephalography (EEG) during human motion can introduce motion artifacts. Repetitive head movements can generate artifact patterns across scalp EEG sensors. There are many methods for identifying and rejecting bad channels and independent components from EEG datasets, but there is a lack of methods dedicated to evaluate specific intra-channel amplitude patterns for identifying motion-related artifacts. In this study, we proposed a template correlation rejection (TCR) as a novel method for identifying and rejecting EEG channels and independent components carrying motion-related artifacts. We recorded EEG data from 10 subjects during treadmill walking. The template correlation rejection method consists of creating templates of amplitude patterns and determining the fraction of total epochs presenting relevant correlation to the template. For EEG channels, the template correlation rejection removed channels presenting the majority of epochs (>75%) correlated to the template, and presenting pronounced amplitude in comparison to all recorded channels. For independent components, the template correlation rejection removed components presenting the majority of epochs correlated to the template. Evaluation of scalp maps and power spectra confirmed low neural content for the rejected components. We found that channels identified for rejection contained ~60% higher delta power, and had spectral properties locked to the gait phases. After rejecting the identified channels and running independent component analysis on the EEG datasets, the proposed method identified 4.3 ± 1.8 independent components (out of 198 ± 12) with substantive motion-related artifacts. These results indicate that template correlation rejection is an effective method for rejecting EEG channels contaminated with motion-related artifact during human locomotion.

  12. A Channel Rejection Method for Attenuating Motion-Related Artifacts in EEG Recordings during Walking

    Directory of Open Access Journals (Sweden)

    Anderson S. Oliveira

    2017-04-01

    Full Text Available Recording scalp electroencephalography (EEG during human motion can introduce motion artifacts. Repetitive head movements can generate artifact patterns across scalp EEG sensors. There are many methods for identifying and rejecting bad channels and independent components from EEG datasets, but there is a lack of methods dedicated to evaluate specific intra-channel amplitude patterns for identifying motion-related artifacts. In this study, we proposed a template correlation rejection (TCR as a novel method for identifying and rejecting EEG channels and independent components carrying motion-related artifacts. We recorded EEG data from 10 subjects during treadmill walking. The template correlation rejection method consists of creating templates of amplitude patterns and determining the fraction of total epochs presenting relevant correlation to the template. For EEG channels, the template correlation rejection removed channels presenting the majority of epochs (>75% correlated to the template, and presenting pronounced amplitude in comparison to all recorded channels. For independent components, the template correlation rejection removed components presenting the majority of epochs correlated to the template. Evaluation of scalp maps and power spectra confirmed low neural content for the rejected components. We found that channels identified for rejection contained ~60% higher delta power, and had spectral properties locked to the gait phases. After rejecting the identified channels and running independent component analysis on the EEG datasets, the proposed method identified 4.3 ± 1.8 independent components (out of 198 ± 12 with substantive motion-related artifacts. These results indicate that template correlation rejection is an effective method for rejecting EEG channels contaminated with motion-related artifact during human locomotion.

  13. Urine immunocytology as a noninvasive diagnostic tool for acute kidney rejection: a single center experience.

    Science.gov (United States)

    Mihovilović, Karlo; Kardum-Skelin, Ika; Ljubanović, Danica; Sabljar-Matovinović, Mirjana; Vidas, Zeljko; Knotek, Mladen

    2010-03-01

    Renal biopsy is a gold standard for establishing diagnosis of acute rejection of the renal allograft. However, being invasive, renal biopsy has potential significant complications and contraindications. Therefore, possibility to noninvasively diagnose acute rejection would improve follow-up of kidney transplant patients. The purpose of this study was to evaluate urine immunocytology for T cells as a method for noninvasive identification of patients with acute renal allograft rejection in comparison to renal biopsy. In this prospective study a cohort of 56 kidney, or kidney-pancreas transplant recipients was included. Patients either received their transplant at the University Hospital "Merkur", or have been followed at the "Merkur" Hospital. Patients were subject to either protocol or indication kidney biopsy (a total of 70 biopsies), with simultaneous urine immunocytology (determination of CD3-positive cells in the urine sediment). Acute rejection was diagnosed in 24 biopsies. 23 episodes were T-cell mediated (6 grade IA, 5 grade IB, 1 grade IIA, 1 grade III and 10 borderline), while in 1 case acute humoral rejection was diagnosed. 46 biopsies did not demonstrate acute rejection. CD3-positive cells were found in 21% of cases with acute rejection and in 13% of cases without rejection (n.s.). A finding of CD3-positive cells in urine had a sensitivity of 21% and specificity of 87% for acute rejection (including borderline), with positive predictive value of 45% and negative predictive value of 68%. Although tubulitis is a hallmark of acute T cell-mediated rejection, detection of T cells in urine sediment was insufficiently sensitive and insufficiently specific for diagnosing acute rejection in our cohort of kidney transplant recipients.

  14. Greater positive schizotypy relates to reduced N100 activity during rejection scenes.

    Science.gov (United States)

    Premkumar, Preethi; Onwumere, Juliana; Wilson, Daniel; Sumich, Alexander; Castro, Antonio; Kumari, Veena; Kuipers, Elizabeth

    2014-08-01

    Social anxiety due to rejection sensitivity (RS) exacerbates psychosis-like experiences in the general population. While reduced dorsal anterior cingulate cortex (dACC) activity during social rejection in high schizotypy has suggested self-distancing from rejection, earlier stages of mental processing such as feature encoding could also contribute to psychosis-like experiences. This study aimed to determine the stage of mental processing of social rejection that relates to positive schizotypy. Forty-one healthy participants were assessed for schizotypy and RS. Event-related potential amplitudes (ERPs) were measured at frontal, temporal and parieto-occipital sites and their cortical sources (dACC, temporal pole and lingual gyrus) at early (N100) and late (P300 and late slow wave, LSW) timeframes during rejection, acceptance and neutral scenes. ERPs were compared between social interaction types. Correlations were performed between positive schizotypy (defined as the presence of perceptual aberrations, hallucinatory experiences and magical thinking), RS and ERPs during rejection. Amplitude was greater during rejection than acceptance or neutral conditions at the dACC-P300, parieto-occipital-P300, dACC-LSW and frontal-LSW. RS correlated positively with positive schizotypy. Reduced dACC N100 activity during rejection correlated with greater positive schizotypy and RS. Reduced dACC N100 activity and greater RS independently predicted positive schizotypy. An N100 deficit that indicates reduced feature encoding of rejection scenes increases with greater positive schizotypy and RS. Higher RS shows that a greater tendency to misattribute ambiguous social situations as rejecting also increases with positive schizotypy. These two processes, namely primary bottom-up sensory processing and secondary misattribution of rejection, combine to increase psychosis-like experiences. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Neural processing of social rejection: the role of schizotypal personality traits.

    Science.gov (United States)

    Premkumar, Preethi; Ettinger, Ulrich; Inchley-Mort, Sophie; Sumich, Alexander; Williams, Steven C R; Kuipers, Elizabeth; Kumari, Veena

    2012-03-01

    A fear of being rejected can cause perceptions of more insecurity and stress in close relationships. Healthy individuals activate the dorsal anterior cingulate cortex (dACC) when experiencing social rejection, while those who are vulnerable to depression deactivate the dACC presumably to downregulate salience of rejection cues and minimize distress. Schizotypal individuals, characterized by unusual perceptual experiences and/or odd beliefs, are more rejection sensitive than normal. We tested the hypothesis, for the first time, that individuals with high schizotypy also have an altered dACC response to rejection stimuli. Twenty-six healthy individuals, 14 with low schizotypy (LS) and 12 with high schizotypy (HS), viewed depictions of rejection and acceptance and neutral scenes while undergoing functional MRI. Activation maps in LS and HS groups during each image type were compared using SPM5, and their relation to participant mood and subjective ratings of the images was examined. During rejection relative to neutral scenes, LS activated and HS deactivated the bilateral dACC, right superior frontal gyrus, and left ventral prefrontal cortex. Across both groups, a temporo-occipito-parieto-cerebellar network was active during rejection, and a left fronto-parietal network during acceptance, relative to neutral scenes, and the bilateral lingual gyrus during rejection relative to acceptance scenes. Our finding of dACC-dorso-ventral PFC activation in LS, but deactivation in HS individuals when perceiving social rejection scenes suggests that HS individuals attach less salience to and distance themselves from such stimuli. This may enable them to cope with their higher-than-normal sensitivity to rejection. Copyright © 2011 Wiley Periodicals, Inc.

  16. Impact of acute rejection episodes on long-term renal allograft survival

    Institute of Scientific and Technical Information of China (English)

    吴建永; 陈江华; 王逸民; 张建国; 朱琮; 寿张飞; 王苏娅; 张萍; 黄洪锋; 何强

    2003-01-01

    Objective To assess the impact of the number, and time of acute rejection (AR) and outcome of anti-rejection therapy on the long-term survival of renal allografts and the relative risk factors. Methods The Kaplan-Meier analysis and log-rank test were used to calculate the survival rates of patients and grafts in no acute rejection group (NAR, 895 patients), 1 rejection episode group (1AR, 183), 2 and more than 2 rejection episodes group (2AR, 17), acute rejection group [AR (1AR+2AR), 200], early acute rejection group (within 90 days after transplantation, EAR, 125), late acute rejection group (91 days later, LAR, 58), completely AR reversed group (CAR, 105), and incompletely AR reversed group (IAR, 68). The relative risk factors were analyzed by the Cox proportional hazards regression. Results The 5- and 10-year survival rates of renal allografts were 75.4% and 17.1% in AR and 93.2% and 86.5% in the NAR group (P<0.0001). The long-term graft survival was much lower in the 2AR group than in the NAR or 1AR groups (P<0.0001 and P=0.002, respectively). It was similar in either the NAR or CAR groups (P=0.31), but it was significantly lower (P<0.0001) in the IAR group. Multivariate Cox regression analysis revealed that the outcome of anti-rejection therapy is an important risk factor affecting the long-term survival of allografts.Conclusions AR is significantly associated with poor long-term survival of renal allografts. But the long-term graft survival of patients with one acute rejection but completely reversed is not significantly different from that of patients without acute rejection.

  17. Manuscript Documentation and Conservation Treatment: A Mamluk Manuscript from the 15th Century El Yazmalarında Belgeleme ve Konservasyon Çalışması: 15. Yüzyıldan Bir Memluk El Yazması

    Directory of Open Access Journals (Sweden)

    Nil Baydar

    2004-03-01

    Full Text Available The conservation treatment of a 15th century Mamluk manuscript decorated in a manner suitable to the period is considered in three parts. First, with the goal of establishing the manuscript's technical and material characteristics, a "definition" is made; second, under the heading "the pre-conservation condition", the damage observed in the object and its causes are researched; finally, "the conservation treatments" carried out on the object are explained. The history of prophets, written in black and red ink on handmade paper, is explained in the manuscript. The object's covers and envelope flap are made of laminated paper board covered with goat leather. Some of the kinds of damage observed in the object were: The binding and text block were on the point of separating from each other; it suffered considerable losses because of the "jengar" (copper containing pigments on the object's pages; old restorations had lost their function. During conservation treatment, in the work undertaken separately on the binding and text block, consolidation, filling and mending was done. Guided by macro and micro examinations, this conservation work was carried out in the laboratory of Ankara University, Başkent Vocational School. Bu makalede, dönemine uygun biçimde süslenmiş olan 15. yüzyıl Memluk el yazmasının konservasyon çalışmaları üç bölümde ele alınacaktır. İlk olarak el yazmasının teknik ve hammadde özelliklerini saptamak amacıyla "tanımlama" yapılmıştır. İkinci olarak, "konservasyon öncesi durum" başlığı altında objede tespit edilen bozulmalar ve nedenleri irdelenmiş, son olarak da objeye uygulanan "konservasyon işlemleri" anlatılmıştır. El yapımı kağıt üzerine siyah ve kırmızı mürekkeple yazılmış olan el yazmasında peygamberler tarihi anlatılmaktadır. Objenin kapakları ve mıklebi murakka kartondan olup üstü keçi derisi ile kaplanmıştır. Cilt ile metin kısmının birbirinden ayrılmak

  18. Expression of Cytokines in Acute Heart Transplantation Rejection

    Institute of Scientific and Technical Information of China (English)

    XIA Jiahong; XU Lei; YANG Chenyuan

    2006-01-01

    The expression and changes of local cytokines network were detected in heart transplantation in rats, so as to determine the role of cytokines in the acute rejection of rats of heart transplantation. Allografts were divided into 4 groups (n=12 in each group): group A (control), group B (IL-2 monoclonal antibody-treated), group C (CsA-treated) and group D (IL-2 monoclonal antibody+CsA-treated). Hearts from DA rats were transplanted into a cervical location in Wistar recipients. The local expression of IL-1β, IL-2, CD25, IL-4, IL-5, IL-6, IL-10, TNFα and INFγ was detected at day 1, 3, 5, 7, 9, 11 and 14 by reverse transcription polymerase chain reaction. The results showed that the survival time of allografts was 8.3±1.7, 29.2±7.1 (P<0.05), 26.4±5.7 (P<0.05) and 55.0±10.6 (P<0.01) days respectively in groups A, B, C and D. The expression of IL-1β, IL-4, IL-10and IFNγ was up-regulated, and that of IL-2, CD25, IL-5, IL-6 and TNFα was significantly inhibited in group A; The expression of IL-1β, IL-5, IL-6, IL-10 and IFNγ was up-regulated, and that of IL-2,IL-4 and TNFα was significantly down-regulated in group B; The expression of IL-1β, IL-2, CD25,IL-5, TNFα and IFNγ was up-regulated, and that of IL-4, IL-6 and IL-10 was significantly down-regulated in group C; The expression of IL-14, Il-5, IL-6 and Il-10 was up-regulated, and that of IL-1β, IL-2, CD25, TNFα and IFNγ was significantly down-regulated in group D. In conclusion,cytokines play an important role in the development of acute transplantation rejection. Different cytokines play different roles in different local environments.

  19. Non-destructive analysis for the inspection and control of metalic monuments and historical manuscripts; Zerstoerungsfreie Analytik zur Ueberwachung von metallischen Kunstwerken und historischen Handschriften

    Energy Technology Data Exchange (ETDEWEB)

    Faubel, W.; Heissler, S.; Klewe-Nebenius, H.; Willin, E. [Forschungszentrum Karlsruhe Umwelt und Technik GmbH (Germany). IFIA

    2003-07-01

    As a contribution to the increasing efforts to preserve cultural heritage of historical bronze monuments exposed to atmospheric corrosion as well as historical books and manuscripts non-destructive analytical methods are highly desirable enabling an in-situ examination of the surface status of an object. The development and application of novel non-destructive analytical methods based on the photoacoustic and photothermal deflection spectroscopy allowed to investigate the state of bronze patina as well as the effectiveness of conservation procedures for historical manuscripts. (orig.)

  20. Flirtation Rejection Strategies: Toward an Understanding of Communicative Disinterest in Flirting

    Science.gov (United States)

    Goodboy, Alan K.; Brann, Maria

    2010-01-01

    Single adults often seek successful flirtatious encounters; yet these encounters can sometimes be considered failures. However, little research has identified flirtation rejection strategies enacted by those not interested in reciprocal flirting. The purpose of this study was to examine behavioral and verbal flirtation rejection strategies among…