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Sample records for reiska patrik scheinin

  1. Laps ja loodus / Patrik Grahn

    Index Scriptorium Estoniae

    Grahn, Patrik

    2009-01-01

    Looduses viibimise ja mängimise tähtsusest lapse arengus. Artiklis tuginetakse uurimustele looduse, parkide ja aedade erinevate omadustega tüüpidest, eelkooliõuede õuemängude kohtadest ning looduspiirkondade tähendusest laste tervisele, motoorikale ja keskendumisvõimele

  2. Mäetaguse mõisa tall-tõllakuuri ümberehitamine hotelliks / Ermo Reiska

    Index Scriptorium Estoniae

    Reiska, Ermo

    2006-01-01

    Muinsuskaitse eritingimused: A. Pantelejev. Projekt: AS Restor. Ehitaja: OÜ Vet Ehitus Grupp. Muinsuskaitseline järelevalve: OÜ Zoroaster, Aivo Raud. Tall-tõllakuuri ümberehitamisel hotelliks "Meintack" säilitati hoone ajaloolistes gabariitides, restaureeriti fassaadid, taastati endine kelpkatus ning ühendati juurdeehituse abil endise veskihoonega

  3. STS-õpetus ja traditsiooniline füüsikaõpetus / Priit Reiska

    Index Scriptorium Estoniae

    Reiska, Priit, 1970-

    2000-01-01

    Rahvusvahelisest uurimisprojektist, mis viidi läbi Tallinna Pedagoogikaülikooli ja Kieli Ülikooli koostööna, võrdlemaks teadmiste omandamist SATIS-õpetuse ja traditsioonilise õpetusega. Eesti ja Saksamaa õpilaste teadmiste erinevused

  4. Download this PDF file

    African Journals Online (AJOL)

    10332324

    imposes on TNCs may amount to ethical duties at best".13 ... Business Enterprises with Regard to Human Rights (2003), and the UN "Protect, Respect and ... According to the Velasquez Rodriquez court case,19 which formulated the due ...... Scheinin M (eds) International Protection of Human Rights: A Textbook 2nd ed.

  5. Mälupulga kaotaja sai karistada / Tarmo Vahter

    Index Scriptorium Estoniae

    Vahter, Tarmo, 1970-

    2007-01-01

    Tarkvarafirma Mindworks Industries töötaja kaotas mälupulga, millel olid 302 067 kaitseväekohuslase isikuandmed. Firma osaniku ja tegevjuhi Kaspar-Patrik Loidi ülekuulamisest andmekaitse inspektsiooni vaneminspektori Veigo Rivise poolt

  6. Aasta õpetajad 2008 / Sirje Semm

    Index Scriptorium Estoniae

    Semm, Sirje, 1950-

    2008-01-01

    EELK vaimulike konverentsil valiti aasta kirikuõpetajateks Lääne-Harju praostkonna praost, Hageri koguduse õpetaja Jüri Vallsalu ja Rootsi-Mihkli koguduse õpetaja, Tallinna praostkonna abipraost Patrik Göransson

  7. Uuenenud otsustuskogu : senat / Hille Erik

    Index Scriptorium Estoniae

    Erik, Hille

    2005-01-01

    12. septembril kogunes esimest korda TLÜ kollegiaalne otsustuskogu - senat: M. Heidmets, H. Mattisen, P. Normak, M. Lepik, M. Talsi, S. Liiv, P. Reiska, K. Port, E. Rüütel, A. Kivinukk, A. Pulver, R. Raud, E. Eisenschmidt, K. Karron, H. Šein, P. Raudkivi, A. Kollist, K. Katus, K. Loogma, R. Vetik, J.-M. Punning, M. Ehala, P. Tammela, T. Tõnise, L. Läänemets, L. Saareväli, A. King

  8. Kolmene ülikool esitles professoreid ja kirjanduspreemia laureaate

    Index Scriptorium Estoniae

    2008-01-01

    Tallinna Ülikool esitles 3. aastapäeva aktusel aasta jooksul professoreiks valituid: Lorenzo Cañás Bottos, Jyrki Käkönen, Aaro Toomela, Airi Värnik, Marika Mägi, Priit Reiska, Eve Kikas ja Karsten Brüggemann. Selgusid ka tänavused Tallinna Ülikooli kirjanduspreemia laureaadid. Algupärase ilukirjanduse vallas pälvis auhinna romanist, luuletaja ja tõlkija, doktorant Maarja Kangro, tõlkepreemia sai kirjanik ja tõlkija Arvo Valton

  9. Öö täis õuduseid / Signe Sillasoo

    Index Scriptorium Estoniae

    Sillasoo, Signe

    2009-01-01

    PÖFFi ja Tudengipäevade öiste filmiseansside sarja esimesest filmiööst Night Of the Movie Eaters 21. aprillil kinos Sõprus, mil kavas kolm õudusfilmi : Mark ja Jay Duplass' "Kottpea" (USA, 2008), Patrik Syverseni "Inimjaht" (Norra, 2008), Yoshihiro Nishimura "Tokyo Gore Police" (Jaapan, 2008)

  10. Pinocchio, Capone ja teised klaasist kangelased / Tanel Veenre

    Index Scriptorium Estoniae

    Veenre, Tanel, 1977-

    2011-01-01

    Näitus "Kaasaegne Slovakkia klaasikunst" Eesti Tarbekunsti- ja Disainimuuseumis" 10. aprillini 2011, kuraator Zora Petrášová. Václav Cigleri mõjust slovaki klaasikunsti arengusse, Patrik Illo, Miloš Balgavy, Ján Zoričaki ja Palo Macho töödest

  11. Rootsi-Mihkli kirikus on jälle jõulud / Tiina Kanarbik

    Index Scriptorium Estoniae

    Kanarbik, Tiina

    2003-01-01

    1992. a. tagastatud Rootsi-Mihkli kogudus maja sai 2002. a. kevadeks uue katuse ja välisviimistluse, kirikusaal ning osa koguduseruume olid restaureeritud ja renoveeritud. Kiriku varadest. Altari valmistas 1703. a. puunikerdaja Joachim Armbrust, kantsli 1707. a. Christian Ackermann. Pimedate kaitsepühakust Luciast. Kommentaarid kirikuõpetaja Patrik Göranssonilt

  12. "ARS 01", perspektiivide avamine / Helen Kivisoo

    Index Scriptorium Estoniae

    Kivisoo, Helen

    2001-01-01

    30. IX 2001-20. I 2002 Kiasmas kuuendat korda toimuvast rahvusvahelisest näitusest "ARS", kus Eestist osaleb Marko Mäetamm. Kuraatorid Tuula Arkio, Maaretta Jaukkuri, Patrik Nyberg, Jari-Pekka Vanhala. Teemaks "kolmas ruum". Näituse kajastamisest.

  13. Kirgastav slovaki klaas / Anne Tiivel

    Index Scriptorium Estoniae

    Tiivel, Anne

    2011-01-01

    Näitus "Kaasaegne Slovakkia klaasikunst" Eesti Tarbekunsti- ja Disainimuuseumis" 10. aprillini 2011, kuraator Zora Petrášová. 14 osalejat loetletud. Václav Cigleri panusest slovaki klaasikunsti arengusse, Miloš Balgavy, Ján Zoričaki, Palo Macho ja Patrik Illo töödest

  14. MFA Graduate Show 2015: In the Usual Direction of Travel

    OpenAIRE

    2015-01-01

    Avgangsstudenter: Patrik Berg, Christian Magnus Tømmeraas Berg, Maia Birkeland, Matilda Björkne, Stine Bråthen, Stein Are Kjærås Dahl, Emil Gustafsson, Jeanett Gustavsen, hÅkon gÅre, Jørgen Frederik Scheel Haarstad, Anita Hanch-Hansen, Elin Hedberg, Andrea Wikhammer Heir, Steinar Laumann, Aron-Irving Li, Tina Lindvall, Rebecca Szabo Onstad, Zahra Rashid, Hege Cathrine Hauge Thoresen

  15. Konsolidácia účtovnej závierky vo verejnej správe Slovenskej republiky

    OpenAIRE

    Rybníčková, Veronika

    2014-01-01

    Rybničková V., Consolidated financial statement in public sector in Slovakia, bachelor thesis. Ing. Patrik Svoboda Ph. D. - supervisor, Mendel University in Brno, 2014. This thesis deals with consolidated financial statement in Slovak public sector. The legislation needed for consolidation, as well as its importance in public sector is described, but also the methods of consolidation are explained on specific examples. The thesis is composed of the consolidation process itself, and the subseq...

  16. Jakob Johannes Sederholm

    Science.gov (United States)

    Eklund, O.; Korsman, K.; Scheinin, B.

    2010-05-01

    Jakob Johannes Sederholm (1863-1934) was one of the more influential pioneers in Precambrian geology having introduced some fundamental insights and concepts which are still relevant today. Towards the end of the 19th century, he demonstrated how the principle of actualism can be applied to Precambrian terranes, while during the early part of the 20th century he undertook detailed studies on deformed magmatic rocks, both defining and interpreting the enigmatic mixed rocks now known as migmatites. He acted as the head of the Geological Survey of Finland for 40 years, which developed under his leadership into a modern progressive and versatile research organization. In addition, Sederholm also served as a diplomat with a number of international assignments, including appointments with the League of Nations in missions in Albania and a supervisory role relating to sovereignty and autonomy issues in the Åland Island. Several mountains in Greenland have been named after him and his family, and he was also appointed as honorary chief of two Indian tribes in Canada. To understand the driving forces behind a man of his kind, we focus here on Sederholm the person and some of the social and cultural background that influenced his career. This text is based on the book, published in Swedish, entitled "Jakob Johannes Sederholm, Geolog, humanist och sanningssökare" (Scheinin and Korsman, 2007), and an interview with J.J. Sederholm's granddaughter Barbro Scheinin by Eklund (2008). Other references are marked in the text. The first author is responsible for all translations from Swedish, Norwegian, German and Finnish.

  17. LIGA-based microsystem manufacturing:the electrochemistry of through-mold depostion and material properties.

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, James J. (Sandia National Laboratories, Livermore, CA); Goods, Steven Howard (Sandia National Laboratories, Livermore, CA)

    2005-06-01

    The report presented below is to appear in ''Electrochemistry at the Nanoscale'', Patrik Schmuki, Ed. Springer-Verlag, (ca. 2005). The history of the LIGA process, used for fabricating dimensional precise structures for microsystem applications, is briefly reviewed, as are the basic elements of the technology. The principal focus however, is on the unique aspects of the electrochemistry of LIGA through-mask metal deposition and the generation of the fine and uniform microstructures necessary to ensure proper functionality of LIGA components. We draw from both previously published work by external researchers in the field as well as from published and unpublished studies from within Sandia.

  18. Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

    Science.gov (United States)

    Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A; Lundström, Patrik

    2015-01-01

    The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available.

  19. Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

    Directory of Open Access Journals (Sweden)

    Markus Niklasson

    2015-01-01

    Full Text Available The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available.

  20. Zaha Hadid: Between the Visionary and the Pragmatic

    Directory of Open Access Journals (Sweden)

    Georgi Stanishev

    2017-09-01

    Since the establishment of partnership between Hadid and Patrik Schumacher, the studio had focused on computer and parametric planning strategies. The Parametricist Manifesto (2008 became the culmination of that direction. The parametric design guides Zaha toward searching for new relations between architecture and modeling of forms of field conditions, force lines and fluid processes in nature. Computer mathematics models evolutionary processes of the occurrence of natural forms in the living and non-living environment… Within the last decades, influenced by Schumacher’s parametric ideology, Hadid’s projects have more and more imitated the natural processes of creation of spatial and formal models resembling the organic world. The text given below, however, reveals the roots of Zaha’s architectural ideology, that developed at the edge of the 1980s and 90s on the basis of Russian avant-garde art and architecture, and partially hidden resonances with the inner world of the East.

  1. THE STRENGTHENING OF NATIONALISM AMONG THE PEOPLE OF PAPUA, INDONESIA

    Directory of Open Access Journals (Sweden)

    Bernada Meterai

    2015-07-01

    Full Text Available This study is the phenomenon of "problem Indonesian Papuans" often questionable when the "conflict-torn Papua." LIPI in 2007 questioned why it's been 62 years of independent Indonesia, Papua Indonesia nationalism began to be questioned again. We all know that Papua is the province of the very rich natural resources, beautiful panoramic views both on land and at sea to original culture from a number of ethnic groups. the Papua origin ball players like Boaz Salosa, Patrik Wanggai, Ferdinando Pahabol and Riki Kayame continued fighting defend their self-esteem as a nation of Indonesia in the field that when dealing with other countries. However, when the conflict in Papua occurred, appeared a wide pernyataantentang of Papua New Guinea such as: dark, human resources is relatively low, people are still poor and primitive, and the flag frequently offered up morning, arcane, the shooting of human rights violations, the referendum and the independence of the territory of a unitary State the Republic of Indonesia

  2. Adhesion of osteoblasts to a nanorough titanium implant surface

    Directory of Open Access Journals (Sweden)

    Gongadze E

    2011-08-01

    Full Text Available Ekaterina Gongadze1, Doron Kabaso2, Sebastian Bauer3, Tomaž Slivnik2, Patrik Schmuki3, Ursula van Rienen1, Aleš Iglič21Institute of General Electrical Engineering, University of Rostock, Rostock, Germany; 2Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia; 3Department of Materials Science, Friedrich-Alexander University of Erlangen-Nurenberg, Erlangen, GermanyAbstract: This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges. The basic assumption was that the attraction between the negatively charged titanium surface and a negatively charged osteoblast is mediated by charged proteins with a distinctive quadrupolar internal charge distribution. Similarly, cation-mediated attraction between fibronectin molecules and the titanium surface is expected to be more efficient for a high surface charge density, resulting in facilitated integrin mediated osteoblast adhesion. We suggest that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest. It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts.Keywords: osteoblasts, nanostructures, adhesion, titanium implants, osteointegration

  3. In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model

    Directory of Open Access Journals (Sweden)

    Nyman E

    2013-01-01

    Full Text Available Eva Nyman,1,* Bo Franzén,1,* Andreas Nolting,1 Göran Klement,1 Gang Liu,1 Maria Nilsson,1 Annika Rosén,2 Charlotta Björk,3 Dirk Weigelt,4 Patrik Wollberg,1 Paul Karila,1 Patrick Raboisson11Neuroscience, Innovative Medicines CNS/Pain, AstraZeneca R&D, Södertälje, Sweden; 2Division of Oral and Maxillofacial Surgery, Karolinska Institute/Karolinska University Hospital, Huddinge, Sweden; 3Clinical TA NS Early Development, 4Medicinal Chemistry, Innovative Medicines CNS/Pain, AstraZeneca R&D, Södertälje, Sweden*These authors contributed equally to this workAbstract: AZ465 is a novel selective transient receptor potential cation channel, member A1 (TRPA1 antagonist identified during a focused drug discovery effort. In vitro, AZ465 fully inhibits activation by zinc, O-chlorobenzylidene malononitrile (CS, or cinnamaldehyde of the human TRPA1 channel heterologously expressed in human embryonic kidney cells. Our data using patch-clamp recordings and mouse/human TRPA1 chimeras suggest that AZ465 binds reversibly in the pore region of the human TRPA1 channel. Finally, in an ex vivo model measuring TRPA1 agonist-stimulated release of neuropeptides from human dental pulp biopsies, AZD465 was able to block 50%–60% of CS-induced calcitonin gene-related peptide release, confirming that AZ465 inhibits the native human TRPA1 channel in neuronal tissue.Keywords: pain, pharmacology, antagonist, chimeric proteins, dental pulp, inflammation, neuropeptide, calcitonin gene-related peptide, CGRP

  4. The Comparison of Relationship between Family Communication Patterns and Self Concept with Coping Styles in Male and Female Students

    Directory of Open Access Journals (Sweden)

    R Taheri

    2012-10-01

    Full Text Available Background & Aim: Since people have different coping styles, the purpose of the present research was to compare the relationship between family communication patterns and self-concept with coping styles among male and female students of Eram Higher Education Institution in Shiraz. Methods: In the present correlation study conducted in 2011 at Eram Higher Education Institution in Shiraz, 229 participants (91 males &119 females were selected by simple random sampling method. Data was collected by using the revised version of family communication patterns questionnaire (RFCP, Koerner & Fitz patrik (2002, Beck's Self-concept Test (CST (1990 and Coping Inventory for Stressful Situations (CISS Endler & Parker (1990. Data was analyzed using correlation matrix & independent t-test analysis. Results: According to the result, there was significant correlation between family communication patterns and self-concept with coping styles among male and female students. In the female group, task oriented coping and avoidance oriented coping with conversation orientation and emotion oriented coping with conforming orientation showed positive significant correlation. In male group avoidance orientation coping with conversation orientation and emotion oriented coping with conforming orientation showed positive significant correlation. Also, related to self concept variable, results showed female students task oriented coping and avoidance oriented coping had significant correlation with the self concept variable, but the male students avoidance oriented coping had significant correlation with the self concept variable(P<0/05. Also, the result showed significant difference between two male and female students, in emotion oriented coping, so the female group, emotion oriented coping with (51/48 was more than the orientation within the male group with (48/18, (p<0.05. Conclusion: Family communication patterns and the concept are effective on coping styles. Therefore

  5. Specific proteins of the trapezius muscle correlate with pain intensity and sensitivity – an explorative multivariate proteomic study of the trapezius muscle in women with chronic widespread pain

    Directory of Open Access Journals (Sweden)

    Olausson P

    2016-06-01

    Full Text Available Patrik Olausson, Bijar Ghafouri, Nazdar Ghafouri, Björn Gerdle Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden Abstract: Chronic widespread pain (CWP including fibromyalgia syndrome (FMS has a high prevalence and is associated with prominent negative consequences. CWP/FMS exhibits morphological and functional alterations in the central nervous system. The importance of peripheral factors for maintaining the central alterations are under debate. In this study, the proteins from biopsies of the trapezius muscle from 18 female CWP/FMS patients and 19 healthy female controls were analyzed. Pain intensity and pressure pain thresholds (PPT over the trapezius muscles were registered. Twelve proteins representing five different groups of proteins were important regressors of pain intensity in CWP/FMS (R2=0.99; P<0.001. In the regression of PPT in CWP/FMS, it was found that 16 proteins representing six groups of proteins were significant regressors (R2=0.95, P<0.05. Many of the important proteins were stress and inflammation proteins, enzymes involved in metabolic pathways, and proteins associated with muscle damage, myopathies, and muscle recovery. The altered expression of these proteins may reflect both direct and indirect nociceptive/inflammatory processes as well as secondary changes. The relative importance of the identified proteins and central alterations in CWP need to be investigated in future research. Data from this and the previous study concerning the same cohorts give support to the suggestion that peripheral factors are of importance for maintaining pain aspects in CWP/FMS. Keywords: chronic widespread pain, proteomics, biomarkers, multivariate data analysis, pain threshold, numeric rating scale

  6. Multivariate proteomic analysis of the cerebrospinal fluid of patients with peripheral neuropathic pain and healthy controls – a hypothesis-generating pilot study

    Directory of Open Access Journals (Sweden)

    Bäckryd E

    2015-07-01

    Full Text Available Emmanuel Bäckryd,1,2 Bijar Ghafouri,1,2 Anders K Carlsson,1,2 Patrik Olausson,1,2 Björn Gerdle1,2 1Division of Community Medicine, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden; 2Pain and Rehabilitation Centre, Anaesthetics, Operations and Specialty Surgery Centre, Region Östergötland, Linköping, SwedenAbstract: Pain medicine lacks objective biomarkers to guide diagnosis and treatment. Combining two-dimensional gel proteomics with multivariate data analysis by projection, we exploratively analyzed the cerebrospinal fluid of eleven patients with severe peripheral neuropathic pain due to trauma and/or surgery refractory to conventional treatment and eleven healthy controls. Using orthogonal partial least squares discriminant analysis, we identified a panel of 36 proteins highly discriminating between the two groups. Due to a possible confounding effect of age, a new model with age as outcome variable was computed for patients (n=11, and four out of 36 protein spots were excluded due to a probable influence of age. Of the 32 remaining proteins, the following seven had the highest discriminatory power between the two groups: an isoform of angiotensinogen (upregulated in patients, two isoforms of alpha-1-antitrypsin (downregulated in patients, three isoforms of haptoglobin (upregulated in patients, and one isoform of pigment epithelium-derived factor (downregulated in patients. It has recently been hypothesized that the renin–angiotensin system may play a role in the pathophysiology of neuropathic pain, and a clinical trial of an angiotensin II receptor antagonist was recently published. It is noteworthy that when searching for neuropathic pain biomarkers with a purely explorative methodology, it was indeed a renin–angiotensin system protein that had the highest discriminatory power between patients and controls in the present study. The results from this hypothesis

  7. Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women – a multivariate explorative cross-sectional study

    Directory of Open Access Journals (Sweden)

    Olausson P

    2017-03-01

    Full Text Available Patrik Olausson, Bijar Ghafouri, Emmanuel Bäckryd, Björn Gerdle Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden Introduction: Frequent chronic local pain can develop into chronic widespread pain (CWP. The spread of pain is correlated with pain intensity, anxiety, and depression, conditions that ultimately lead to a poor quality of life. Knowledge is incomplete about CWP’s etiology, although it has been suggested that both central hyperexcitability and/or a combination with peripheral factors may be involved. Cerebrospinal fluid (CSF could act as a mirror for the central nervous system as proteins are signal substances that activate the formation of algesics and control nociceptive processes. To this end, this study investigates the CSF protein expression in women with CWP and in female healthy controls. Materials and methods: This study included 12 female patients with CWP diagnosed according to the American College of Rheumatology criteria with 13 healthy age- and sex-matched pain-free subjects. All subjects went through a clinical examination and answered a health questionnaire that registered sociodemographic and anthropometric data, pain characteristics, psychological status, and quality of life rating. CSF was collected by lumbar puncture from each subject. Two-dimensional gel electrophoresis in combination with mass spectrometry was used to analyze the CSF proteome. This study identifies proteins that significantly discriminate between the two groups using multivariate data analysis (MVDA (i.e., orthogonal partial least squares discriminant analysis [OPLS-DA]. Results: There were no clinically significant levels of psychological distress and catastrophization presented in subjects with CWP. MVDA revealed a highly significant OPLS-DA model where 48 proteins from CSF explained 91% (R2 of the variation and with a prediction of 90% (Q2. The highest discriminating

  8. Birth weight, sex, and celiac disease: a nationwide twin study

    Directory of Open Access Journals (Sweden)

    Kuja-Halkola R

    2017-11-01

    Full Text Available Ralf Kuja-Halkola,1 Benjamin Lebwohl,1,2 Jonas Halfvarson,3 Louise Emilsson,4–6 Patrik K Magnusson,1 Jonas F Ludvigsson1,2,7,8 1Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 2Department of Medicine, Celiac Disease Center, Columbia University Medical Center, Columbia University, New York, NY, USA; 3Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 4Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Oslo, Norway; 5Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; 6Centre for Clinical Research, Vårdcentralen Värmlands Nysäter, County Council of Värmland, Värmland, 7Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; 8Division of Epidemiology and Public Health, School of Medicine, City Hospital, University of Nottingham, Nottingham, UK Objective: Earlier research suggests that birth weight may be associated with celiac disease (CD, but the direction of association has been unclear potentially due to confounding effect from genetic and intrafamilial factors. Through within-twin analyses, we aimed to minimize confounding effects such as twins that share genetic and early environmental exposures.Materials and methods: Using the Swedish Twin Registry, we examined the birth weight of 146,830 twins according to the CD status. CD was defined as having villous atrophy according to a small intestinal biopsy reports.Results: The prevalence of diagnosed CD was 0.5% (n=669, and we included 407 discordant pairs of CD–non-CD twins. Comparing the 669 CD patients with non-CD twins, the association between birth weight and future CD was not statistically significant (odds ratio [OR] per 1000 g increase in birth weight: 1.16; 95% confidence interval [CI]=0.97–1.38. In males, the association was positive and statistically significant (OR=1.50; 95% CI

  9. Binding of plasma proteins to titanium dioxide nanotubes with different diameters

    Directory of Open Access Journals (Sweden)

    Kulkarni M

    2015-02-01

    Full Text Available Mukta Kulkarni,1,* Ajda Flašker,1,* Maruša Lokar,1 Katjuša Mrak-Poljšak,2 Anca Mazare,3 Andrej Artenjak,4 Saša Čučnik,2 Slavko Kralj,5 Aljaž Velikonja,1 Patrik Schmuki,3 Veronika Kralj-Iglič,6 Snezna Sodin-Semrl,2,7 Aleš Iglič11Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia; 2Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia; 3Department of Materials Science and Engineering, University of Erlangen Nuremberg, Erlangen, Germany; 4Sandoz Biopharmaceuticals Mengeš, Lek Pharmaceuticals dd, Menges, Slovenia; 5Department for Materials Synthesis, Institute Jožef Stefan (IJS, Ljubljana, Slovenia; 6Faculty of Health Studies, University of Ljubljana, Ljubljana, Slovenia; 7Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia *These authors contributed equally to this workAbstract: Titanium and titanium alloys are considered to be one of the most applicable materials in medical devices because of their suitable properties, most importantly high corrosion resistance and the specific combination of strength with biocompatibility. In order to improve the biocompatibility of titanium surfaces, the current report initially focuses on specifying the topography of titanium dioxide (TiO2 nanotubes (NTs by electrochemical anodization. The zeta potential (ζ-potential of NTs showed a negative value and confirmed the agreement between the measured and theoretically predicted dependence of ζ-potential on salt concentration, whereby the absolute value of ζ-potential diminished with increasing salt concentrations. We investigated binding of various plasma proteins with different sizes and charges using the bicinchoninic acid assay and immunofluorescence microscopy. Results showed effective and comparatively higher protein binding to NTs with 100 nm diameters (compared to 50 or 15 nm. We also showed a dose

  10. Low-pH concrete plug for sealing the KBS-3V deposition tunnels

    Energy Technology Data Exchange (ETDEWEB)

    Malm, Richard (Vattenfall Power Consultant AB (Sweden))

    2012-01-15

    requirement on being watertight, which also affects the design of the concrete plug. In the spent fuel repository, low-pH concrete should be used instead of conventional concrete. The reason for this is to the largest extent to reduce the negative effect that basic materials could have on the function of the bentonite clay. For this purpose, a new low-pH concrete recipe has been developed and this changes the conditions for using reinforcement, cooling and grouting compared to the use of conventional concrete. The report shows the possibilities to use an unreinforced plug made of low-pH concrete as a resistance in the deposition tunnels. Today, some parameters are unknown and some data may be classified as uncertain, primarily regarding the long-term properties of the low-pH concrete material and the bentonite clay. It will take several years until all questions can be answered and a full-scale test is vital to validate the assumptions and the performed numerical simulations. The report should therefore be considered based on that data and conclusions will be studied further and be experimentally verified under realistic and controlled conditions. The project group consists of: Patrik Gatter (VPC), Richard Malm (VPC), Lennart Boergesson (Clay Technology AB), Lars-Olof Dahlstroem (NCC-Teknik), Jonas Magnusson (NCC-Teknik), Christina Claeson-Jonsson (NCC-Teknik), Morgan Johansson (Reinertsen), Rikard Karlzen (SKB), Paer Grahm (SKB), Sten Palmer (Sten Palmer Engineering AB) and Hans Wimelius (NCC AB)

  11. Low-pH concrete plug for sealing the KBS-3V deposition tunnels

    International Nuclear Information System (INIS)

    Malm, Richard

    2012-01-01

    on being watertight, which also affects the design of the concrete plug. In the spent fuel repository, low-pH concrete should be used instead of conventional concrete. The reason for this is to the largest extent to reduce the negative effect that basic materials could have on the function of the bentonite clay. For this purpose, a new low-pH concrete recipe has been developed and this changes the conditions for using reinforcement, cooling and grouting compared to the use of conventional concrete. The report shows the possibilities to use an unreinforced plug made of low-pH concrete as a resistance in the deposition tunnels. Today, some parameters are unknown and some data may be classified as uncertain, primarily regarding the long-term properties of the low-pH concrete material and the bentonite clay. It will take several years until all questions can be answered and a full-scale test is vital to validate the assumptions and the performed numerical simulations. The report should therefore be considered based on that data and conclusions will be studied further and be experimentally verified under realistic and controlled conditions. The project group consists of: Patrik Gatter (VPC), Richard Malm (VPC), Lennart Boergesson (Clay Technology AB), Lars-Olof Dahlstroem (NCC-Teknik), Jonas Magnusson (NCC-Teknik), Christina Claeson-Jonsson (NCC-Teknik), Morgan Johansson (Reinertsen), Rikard Karlzen (SKB), Paer Grahm (SKB), Sten Palmer (Sten Palmer Engineering AB) and Hans Wimelius (NCC AB)

  12. FOREWORD: The 70th birthday of Professor Stig Stenholm The 70th birthday of Professor Stig Stenholm

    Science.gov (United States)

    Suominen, Kalle-Antti

    2010-09-01

    researchers such as Marc-Andre Dupertuis and Steve Barnett worked with Stig at TFT, and in the 1990s it was the turn of Barry Garraway, Ilkka Tittonen and Nikolay Vitanov among others. For his work in 1992-1997 Stig Stenholm received the prestigious Academy of Finland Professorship which provided him with valuable research funds. My graduation in 1992 was followed by Mackillo Kira in 1995 and Päivi Törmä in 1996. Following developments in the field, in the mid-1990s Stig started to work on Bose-Einstein condensation and quantum information. Later he had a Humboldt fellowship, with stays in Germany shared by the Universities at Konstanz (Jürgen Mlynek) and Ulm (Wolfgang Schleich). Unfortunately, the University of Helsinki decided to replace TFT and a corresponding experimental particle physics institute with a new institute, which was mostly seen as the Finnish front-end for CERN collaboration; in 1997 the Helsinki Institute of Physics (HIP) was started. Although the activities of TFT still existed in the theory section of HIP, many things and especially the atmosphere were changed and in 1997 this partly led Stig to accept a position at the Royal Institute of Technology in Stockholm, Sweden, where two of his Finnish students, Patrik Öhberg and Erika Andersson graduated shortly after the move. I moved to HIP at the time, but left for a position in Turku in 2000, and the quantum optics project was finally switched off at HIP in 2003—only later it was found that quantum optics had provided the Institute with its most cited papers, propelling it into the top 5 percent most cited institutes in its field (especially thanks to Norbert Lütkenhaus and his work on quantum cryptography). The time in Stockholm was fruitful for Stig scientifically, but he also became a member of the Royal Swedish Academy of Sciences, and although Nobel committee papers remain secret for 50 years, it is likely that he had a hand in its activities. In 2005 we jointly published a textbook on quantum

  13. EDITORIAL: King of the elements? King of the elements?

    Science.gov (United States)

    Demming, Anna

    2010-07-01

    sensitivity can be enhanced by two orders of magnitude when the graphene is doped with an impurity such as boron [11]. Work on graphene has also prompted the possibility of a new field of application in electron-spin-based quantum computing. In this issue, Patrik Recher and Björn Trauzettel in Germany present an overview on the latest research on quantum dots of graphene, graphene nanoribbons and discs in single- and bilayer graphene with a view to their possible application as qubits in computing [12]. Nanodiamonds with nitrogen vacancies have been shown to behave as quantum-dot-like fluorescent nanostructures that are not susceptible to bleaching. Once certain nanotoxicological concerns have been settled, such nanodiamonds may one day be useful for imaging, and means of industrial scale fabrication have already been reported [13]. Other possible medical applications of carbon nanostructures include the use of carbon nanofibres for improved neural and orthopaedic implants [14]. Electronics, sensing, medicine, quantum computing; the utility of carbon in nanotechnology is apparently unlimited. Of course there is as much work in inorganic research advancing as rapidly and in fields just as diverse. Actual commercialisation of devices based on these carbon wonder materials is still pending, but the extraordinary properties of carbon-based materials holds an unavoidable fascination that is likely to endure and inspire further research and discoveries for some time to come. References [1] Kroto H W, Heath J R, O'Brien S C, Curl R F and Smalley R E 1985 Nature 318 162-3 [2] The Nobel Prize in Chemistry 1996 Nobelprize.org http://nobelprize.org/nobel_prizes/chemistry/laureates/1996 [3] Ijima S 1991 Nature 354 56-38 [4] Treacy M M J, Ebbesen T W and Gibson J M 1996 Nature 381 370-80 [5] Cranford S W and Buehler M J 2010 Nanotechnology 21 265706 [6] Wilder J W G, Venema L C, Rinzler A G, Smalley R E and Dekker C 1997 Nature 391 59-62 [7] Che J, Çagin T and Goddard III W A 2000