Sample records for regulators voltage

  1. Voltage Regulators for Photovoltaic Systems

    Delombard, R.


    Two simple circuits developed to provide voltage regulation for highvoltage (i.e., is greater than 75 volts) and low-voltage (i.e., is less than 36 volts) photovoltaic/battery power systems. Use of these circuits results in voltage regulator small, low-cost, and reliable, with very low power dissipation. Simple oscillator circuit controls photovoltaic-array current to regulate system voltage and control battery charging. Circuit senses battery (and system) voltage and adjusts array current to keep battery voltage from exceeding maximum voltage.


    Grigorash O. V.


    Full Text Available A promising is currently the use of asynchronous generators with capacitive excitation as a source of electricity in stand-alone power systems. Drive asynchronous generators may exercise as a thermal engine and wind wheel wind power plant or turbines of small hydropower plants. The article discusses the structural and schematics of voltage stabilizers and frequency of asynchronous generators with improved operational and technical specifications. Technical novelty of design solutions of the magnetic system and stabilizers asynchronous generator of electricity parameters confirmed by the patents for the invention of the Russian Federation. The proposed technical solution voltage stabilizer asynchronous generators, can reduce the weight of the block capacitors excitation and reactive power compensation, as well as to simplify the control system power circuit which has less power electronic devices. For wind power plants it is an important issue not only to stabilize the voltage of the generator, but also the frequency of the current. Recommend functionality stabilizer schemes parameters of electric power made for direct frequency converters with artificial and natural switching power electronic devices. It is also proposed as part of stabilization systems use single-phase voltage, three-phase transformers with rotating magnetic field, reduce the level of electromagnetic interference generated by power electronic devices for switching, enhance the efficiency and reliability of the stabilizer.

  3. Frequency-controlled voltage regulator

    Mclyman, W. T.


    Converting input ac to higher frequency reduce size and weight and makes possible unique kind of regulation. Since conversion frequency is above range of human hearing, supply generated on audible noise. It also exploits highfrequency conversion features to regulate its output voltage in novel way. Circuit is inherently short-circuit proof.

  4. Simple buck/boost voltage regulator

    Paulkovich, J.; Rodriguez, G. E.


    Circuit corrects low or high supply voltage, produces regulated output voltage. Circuit has fewer components because inductory/transformer combination and pulse-width modulator serve double duty. Regulator handles input voltage variation from as low as one half output voltage to as high as input transistor rating. Solar arrays, fuel cells, and thermionic generators might use this regulator.


    Grigorash O. V.


    Full Text Available Synchronous generators are the primary source of electrical power autonomous electrosupply systems, including backup systems. They are also used in a structure of rotating electricity converters and are widely used in renewable energy as part of wind power plants of small, mini and micro hydroelectric plants. Increasing the speed and the accuracy of the system of the voltage regulation of synchronous generators is possible due to the development of combined systems containing more stabilizers. The article illustrates the functional schemes of circuit voltage stabilizers and frequency synchronous generators (with electromagnetic excitation and permanent magnet excitation and describes the features of their work, including two and three-aggregate rotating converters of electricity used in uninterruptible power supply systems. To improve the technical characteristics of the system of stabilization we have proposed functional solutions for stabilizers of synchronous generators made on the base of direct frequency converters and using a transformer with a rotating magnetic field. To improve the reliability of and to improve the operational characteristics of the autonomous independent sources of electricity we suggest creating the main functional blocks and the elements of the stabilization system in a modular way. The functional circuit solutions of voltage regulators of synchronous generators and the characteristics of their work considered in the article, are able to improve the efficiency of pre-design work in the development of new technical solutions for stabilizing the voltage and the frequency in synchronous generators of electrosupply autonomous systems

  6. Deployment of low-voltage regulator considering existing voltage control in medium-voltage distribution systems

    Hiroshi Kikusato


    Full Text Available Many photovoltaic (PV systems have been installed in distribution systems. This installation complicates the maintenance of all voltages within the appropriate range in all low-voltage distribution systems (LVDSs because the trends in voltage fluctuation differ in each LVDS. The installation of a low-voltage regulator (LVR that can accordingly control the voltage in each LVDS has been studied as a solution to this problem. Voltage control in a medium-voltage distribution system must be considered to study the deployment of LVRs. In this study, we installed LVRs in the LVDSs in which the existing voltage-control scheme cannot prevent voltage deviation and performed a numerical simulation by using a distribution system model with PV to evaluate the deployment of the LVRs.

  7. Coordinated Voltage Control of Distributed PV Inverters for Voltage Regulation in Low Voltage Distribution Networks

    Nainar, Karthikeyan; Pokhrel, Basanta Raj; Pillai, Jayakrishnan Radhakrishna


    This paper reviews and analyzes the existing voltage control methods of distributed solar PV inverters to improve the voltage regulation and thereby the hosting capacity of a low-voltage distribution network. A novel coordinated voltage control method is proposed based on voltage sensitivity...... analysis, which is simple for computation and requires moderate automation and communication infrastructure. The proposed method is suitable for a hierarchical control structure where a supervisory controller has the provision to adapt the settings of local PV inverter controllers for overall system...

  8. A low voltage CMOS low drop-out voltage regulator

    Bakr, Salma Ali; Abbasi, Tanvir Ahmad; Abbasi, Mohammas Suhaib; Aldessouky, Mohamed Samir; Abbasi, Mohammad Usaid


    A low voltage implementation of a CMOS Low Drop-Out voltage regulator (LDO) is presented. The requirement of low voltage devices is crucial for portable devices that require extensive computations in a low power environment. The LDO is implemented in 90nm generic CMOS technology. It generates a fixed 0.8V from a 2.5V supply which on discharging goes to 1V. The buffer stage used is unity gain configured unbuffered OpAmp with rail-to-rail swing input stage. The simulation result shows that the implemented circuit provides load regulation of 0.004%/mA and line regulation of -11.09mV/V. The LDO provides full load transient response with a settling time of 5.2μs. Further, the dropout voltage is 200mV and the quiescent current through the pass transistor (Iload=0) is 20μA. The total power consumption of this LDO (excluding bandgap reference) is only 80μW.

  9. Voltage regulation of connexin channel conductance.

    Oh, Seunghoon; Bargiello, Thaddeus A


    Voltage is an important parameter that regulates the conductance of both intercellular and plasma membrane channels (undocked hemichannels) formed by the 21 members of the mammalian connexin gene family. Connexin channels display two forms of voltage-dependence, rectification of ionic currents and voltage-dependent gating. Ionic rectification results either from asymmetries in the distribution of fixed charges due to heterotypic pairing of different hemichannels, or by channel block, arising from differences in the concentrations of divalent cations on opposite sides of the junctional plaque. This rectification likely underpins the electrical rectification observed in some electrical synapses. Both intercellular and undocked hemichannels also display two distinct forms of voltage-dependent gating, termed Vj (fast)-gating and loop (slow)-gating. This review summarizes our current understanding of the molecular determinants and mechanisms underlying these conformational changes derived from experimental, molecular-genetic, structural, and computational approaches.


    Ajay Dixit*, Miss.Pragati Joshi, Mr.Mahesh Lokhande


    This paper presents on survey paper  of PSO and automatic voltage regulator for synchronous generator. It is used to obtain for regulation and stability of any electrical equipment. There are many technology/methods were used in automatic voltage regulator as well as different controller used for improving robustness, overshoot, rise time and voltage control but problem is about to survey on Automatic Voltage Regulator. Comparisons studies which are based on PID Controller are performed to sh...

  11. Voltage-Sensitive Load Controllers for Voltage Regulation and Increased Load Factor in Distribution Systems

    Douglass, Philip James; Garcia-Valle, Rodrigo; Østergaard, Jacob


    consumption which can be mapped to temperature setpoint offsets of thermostat controlled loads. In networks where a lower voltage level corresponds to high system load (and vice versa), this controller acts to regulate voltage and increase the load factor. Simulations are conducted on low- and medium-voltage......This paper presents a novel controller design for controlling appliances based on local measurements of voltage. The controller finds the normalized voltage deviation accounting for the sensitivity of voltage measurements to appliance state. The controller produces a signal indicating desired power...... distribution systems with residential loads including voltage-sensitive water heaters. In low-voltage systems, the results of the simulations show the controller to be effective at reducing the extremes of voltage and increasing the load factor while respecting end-use temperature constraints. In medium-voltage...

  12. Voltage regulator for battery power source. [using a bipolar transistor

    Black, J. M. (Inventor)


    A bipolar transistor in series with the battery as the control element also in series with a zener diode and a resistor is used to maintain a predetermined voltage until the battery voltage decays to very nearly the predetermined voltage. A field effect transistor between the base of the bipolar transistor and a junction between the zener diode and resistor regulates base current of the bipolar transistor, thereby regulating the conductivity of the bipolar transistor for control of the output voltage.

  13. Comparison of Algorithms for Control of Loads for Voltage Regulation

    Douglass, Philip James; Han, Xue; You, Shi


    Autonomous flexible loads can be utilized to regulate voltag e on low voltage feeders. This paper compares two algorithms for controllin g loads: a simple voltage droop, where load power consumption is a varied in proportio n to RMS voltage; and a normalized relative voltage droop, which modifies...... the simpl e voltage droop by subtracting the mean voltage value at the bus and dividing by the standard deviation. These two controllers are applied to hot water heaters simul ated in a simple residential feeder. The simulation results show that both controllers r educe the frequency of undervoltage events...

  14. Programmable high voltage power supply with regulation confined to the high voltage section

    Castell, Karen D. (Inventor); Ruitberg, Arthur P. (Inventor)


    A high voltage power supply in a dc-dc converter configuration includes a pre-regulator which filters and regulates the dc input and drives an oscillator which applies, in turn, a low voltage ac signal to the low side of a step-up high voltage transformer. The high voltage side of the transformer drives a voltage multiplier which provides a stepped up dc voltage to an output filter. The output voltage is sensed by a feedback network which then controls a regulator. Both the input and output of the regulator are on the high voltage side, avoiding isolation problems. The regulator furnishes a portion of the drive to the voltage multiplier, avoiding having a regulator in series with the load with its attendant, relatively high power losses. This power supply is highly regulated, has low power consumption, a low parts count and may be manufactured at low cost. The power supply has a programmability feature that allows for the selection of a large range of output voltages.

  15. The Control Unit of a Single Phase Voltage Regulator

    Colak, Ilknur


    Supplying regulated voltage to critical loads is an important topic for several years. This paper presents a single-phase electronic voltage regulator based on high frequency switching of an isolated transformer where primary side voltage is controlled by two full-bridge converters sharing a common DC bus and operating at 50Hz and 20kHz switching frequencies. This allows 50Hz induced voltage on the primary side of the transformer, regulated by high frequency switching. Depending on the input voltage, voltage at the secondary side of the transformer add to (boost mode) or subtract (buck mode) from the supply voltage, therefore, maintaining a regulated voltage value across the load. The regulator is controlled by a digital controller allowing fast dynamic response. A 5kVA single-phase voltage regulator is realized to verify the operation of the proposed algorithm. The experimental results show that regulator maintains constant voltage across the load both in step-up (low supply voltage) and step-down (high supp...

  16. Fractional-order Systems and Synchronous Generator Voltage Regulator

    Wojciech Lubośny


    Full Text Available Modern regulators of synchronous generators, including voltage regulators, are digital systems, in their vast majority with standard structures contained in the IEEE standard. These are systems described with stationary differential equations of integral order. Differential equations of fractional order are not employed in regulators for synchronous generator control. This paper presents an analysis of the possibilities of using a system of fractional differential equations in the voltage regulator of an synchronous generator with a static excitation system.

  17. Performance of Three-Arm Ac Automatic Voltage Regulator

    T. Papinaidu


    Full Text Available In this paper the design and simulation of automatic voltage regulator (AVR is proposed. The AVR provides voltage buck and boost capability to eliminate power problems created by under voltage or over voltage fluctuations. It also protects against minor and severe spikes and surges that comprise over 80% of power problems. Over heating of components due to voltage swell is also avoided by using AVR. The switching losses are also reduced as only one arm among three arms is maintained at higher power frequencies depending on mode of operation. Moreover, there is no need to use large capacitor as a result the overall size of converter is also reduced. Hence, the output voltage of the AVR can be maintained at the specified voltage. Hence, the AVR is cost can be reduced, and the efficiency of the power convertor can be extended.

  18. Enhanced current and voltage regulators for stand-alone applications

    Federico, de Bosio; Pastorelli, Michele; Antonio DeSouza Ribeiro, Luiz


    State feedback decoupling permits to achieve a better dynamic response for Voltage Source in stand-alone applications. The design of current and voltage regulators is performed in the discrete-time domain since it provides better accuracy and allows direct pole placement. As the attainable...... bandwidth of the current loop is mainly limited by computational and PWM delays, a lead compensator structure is proposed to overcome this limitation. The design of the voltage regulator is based on the Nyquist criterion, verifying to guarantee a high sensitivity peak. Discrete-time domain implementation...

  19. Global Transient Stability and Voltage Regulation for Multimachine Power Systems

    Gordon, Mark; Hill, David J.


    This paper addresses simultaneously the major fundamental and difficult issues of nonlinearity, uncertainty, dimensionality and globality to derive performance enhancing power system stability control. The main focus is on simultaneous enhancement of transient stability and voltage regulation...... law is implemented to coordinate transient stabilizer and voltage regulator for each machine. Digital simulation studies show that global control scheme achieves unified transient stability and voltage regulation in the presence of parametric uncertainties and significant sudden changes in the network...... of power systems. This problem arises from the practical concern that both frequency and voltage control are important indices of power system control and operation but they are ascribed to different stages of system operation, i.e. the transient and post transient period respectively. The Direct Feedback...


    A. G. Stryzhniou


    Full Text Available The article describes a process of synthesis and qualitative assessment of the harmonic composition of voltages of multiple and single PWM pulses in time regulation, being, along with amplitude, frequency and phase method, one of control methods of an asynchronous motor. The main point of time regulation is that a pause after any two single PWM pulses with different polarity or after any two groups of multiple PWM pulses with different polarity changes during a process of regulation. Feature of time regulation is that a motor has fast response in the range of small-signal of control and good linearity of speed-torque characteristics in the whole control range. Analytical expressions of parameters of PWM pulses ai and ti are obtained which allow to simplify considerably a process of formation and implementation of time regulation using tabular or indexed-tabular methods. These expressions allow not only to define voltage amplitude of  harmonic but also to perform qualitative assessment of harmonic composition of output voltages at time regulation. It is specified that harmonic frequencies wi = w0/q change in inverse proportion to magnitude of parameter q during a process of regulation and there is a replacement of a fundamental frequency by frequencies of higher harmonics.The offered approach allows to synthesize voltage of uniform single and multiple PWM pulses and to perform their comparative and qualitative analysis and the obtained expressions can be used at modeling of AC motor work. Voltage of multiple PWM pulses which is formed using stepped reference voltage with even quantity of steps in a half period and a pause on a zero level has the best parameters by criterion of a minimum of harmonic components and a maximum of a factor of anharmonicity Kнс at time regulation.

  1. Investigation of phase-wise voltage regulator control logics for compensating voltage deviations in an experimental low voltage network

    Hu, Junjie; Zecchino, Antonio; Marinelli, Mattia


    either locally or remotely. To evaluate and compare the control performances of the three control logics, all the tests use the same loading profiles. The experimental results indicate that the modified line compensation control can regulate voltage in a safe band in the case of various load......This paper investigates the control logics of an on-load tap-changer (OLTC) transformer by means of an experimental system validation. The experimental low-voltage unbalanced system consists of a decoupled single-phase OLTC transformer, a 75-metre 16 mm2 cable, a controllable single-phase resistive...... load and an electric vehicle, which has the vehicle-to-grid function. Three control logics of the OLTC transformer are described in the study. The three control logics are classified based on their control objectives and control inputs, which include network currents and voltages, and can be measured...

  2. Fractional-order Systems and Synchronous Generator Voltage Regulator


    Modern regulators of synchronous generators, including voltage regulators, are digital systems, in their vast majority with standard structures contained in the IEEE standard. These are systems described with stationary differential equations of integral order. Differential equations of fractional order are not employed in regulators for synchronous generator control. This paper presents an analysis of the possibilities of using a system of fractional differential equations in the volta...

  3. Voltage Regulator for a dc-to-dc Converter

    Mclyman, C. W.


    New voltage regulator isolates signals from power-switching converter without use of complex circuitry or optical couplers. Only addition is extra secondary winding on existing interstage transformer. Error signals shortcircuit new winding and inhibit converter action. Resistor in series with primary winding limits short-circuit current to prevent damage to circuit components. Extra transformer winding eliminates need for isolation components.

  4. Low input voltage converter/regulator minimizes external disturbances


    Low-input voltage converter/regulator constructed in a coaxial configuration minimizes external magnetic field disturbance, suppresses radio noise interference, and provides excellent heat transfer from power transistors. It converts the output of fuel and solar cells, thermionic diodes, thermoelectric generators, and electrochemical batteries to a 28 V dc output.

  5. A New Secondary Control Approach for Voltage Regulation in DC Microgrids

    Peyghami Akhuleh, Saeed; Mokhtari, Hossein; Davari, Pooya;


    feeders with much voltage drop on the line resistances, the conventional methods may not guarantee the voltage regulation on the load busses. Therefore, in addition to compensate the voltage drop of the primary controller, it is necessary to regulate the voltage of critical loads. In this paper, a new...

  6. Perbaikan Jatuh Tegangan Dengan Pemasangan Automatic Voltage Regulator

    Ija Darmana


    Full Text Available Pada jaringan distribusi telah dipertimbangkan kemungkinan-kemungkinan terjadinya penurunan tegangan karena beban puncak akibat penambahan beban dan pelepasan beban disisi konsumen.Dengan adanya variasi beban, maka disisi konsumen pada saat tertentu akan terjadi variasi tegangan yang besarnya berada antara tegangan minimum dan tegangan maksimum. Untuk mengatasi masalah ini, dapat dilakukan dengan pemasangan kapasitor shunt atau pemasangan Automatic Voltage Regulator (AVR. Adapun titik-titik beban tempat pemasangan kapasitor shunt adalah gardu hubung Painan sebesar 600 kVAR. Dengan pemasangan kapasitor ini  profil tegangan di titik beban untuk gardu hubung Painan ke Balai Selasa mengalami kenaikan tetapi belum memenuhi sesuai dengan yang diharapkan karena masih adanya rugi-rugi tegangan gardu hubung Surantih dan Balai Selasa. Oleh karena itu dilakukan pemasangan  Automatic Voltage Regulator (AVR  diletakkan pada gardu hubung Painan.Setelah pemasangan AVR didapat hasil perhitungan kenaikan tegangan pada gardu hubung Painan sebesar 20,4123 kV, Surantih sebesar 19,5916 kV dan Balai Selasa sebesar 18,6180 kV. Setelah pemasangan Automatic Voltage Regulator  (AVR dilakukan pada gardu hubung Painan telah memenuhi stendard kecil dari 10% tegangan normal, artinya performansi sistem distribusi akan menjadi lebih baik dan handalKata kunci : Perbaikan faktor daya, AVR.

  7. A New Secondary Control Approach for Voltage Regulation in DC Microgrids

    Peyghami Akhuleh, Saeed; Mokhtari, Hossein; Davari, Pooya


    In this paper the effect of secondary controller on voltage regulation in dc Micro-Grids (MGs) is studied. Basically, centralized or decentralized secondary controller has been employed to regulate the voltage drop raised by the primary controller. However, in the case of high capacity MGs and long...... feeders with much voltage drop on the line resistances, the conventional methods may not guarantee the voltage regulation on the load busses. Therefore, in addition to compensate the voltage drop of the primary controller, it is necessary to regulate the voltage of critical loads. In this paper, a new...... voltage regulation strategy is proposed to regulate the voltage of MG by employing the average voltage of identified busses, which are determined by the proposed modal analysis. Numerical steady state analysis and preliminary simulation results validate effectiveness of the proposed scheme. Furthermore...

  8. Optimal Distributed Voltage Regulation in Power Distribution Networks

    Lam, Albert Y S; Dominguez-Garcia, Alejandro; Tse, David


    In this paper, we address the problem of voltage regulation in power distribution networks with deep-penetration of distributed energy resources (DERs), e.g., renewable-based generation, and storage-capable loads such as plug-in hybrid electric vehicles. We cast the problem as an optimization program, where the objective is to minimize the losses in the network subject to constraints on bus voltage magnitudes, limits on active and reactive power injections, transmission line thermal limits and losses. We provide sufficient conditions under which the optimization problem can be solved via its convex relaxation. Using data from existing networks, we show that the conditions are expected to be satisfied by most networks. We also provide an efficient distributed algorithm to solve the problem. The algorithm is asynchronous, with a communication topology that is the same as the electrical network topology. We illustrate the algorithm's performance in the IEEE 34-bus and the 123-bus feeder test systems.

  9. 46 CFR 111.12-7 - Voltage regulation and parallel operation.


    ... 46 Shipping 4 2010-10-01 2010-10-01 false Voltage regulation and parallel operation. 111.12-7... ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Generator Construction and Circuits § 111.12-7 Voltage regulation and parallel operation. Voltage regulation and parallel operation must meet: (a) For AC systems: sections...

  10. A novel full soft-switching resonant power converter for mid-feeder voltage regulation of low voltage distribution network

    Ji, Chao; Watson, Alan James; Clare, Jon C.; Johnson, Christopher Mark


    This paper presents a novel resonant based, high power density power electronics converter solution for mid-feeder voltage regulation of a low voltage (LV) distribution network. Owing to the use of high switching frequency operation and a full soft-switching control strategy, the proposed converter is capable of superimposing LV compensation into the feeder voltage, to achieve a significant system effect with a compact system volume and correspondingly smaller absolute power loss.

  11. The Series Connected Buck Boost Regulator Concept for High Efficiency Light Weight DC Voltage Regulation

    Birchenough, Arthur G.


    Improvements in the efficiency and size of DC-DC converters have resulted from advances in components, primarily semiconductors, and improved topologies. One topology, which has shown very high potential in limited applications, is the Series Connected Boost Unit (SCBU), wherein a small DC-DC converter output is connected in series with the input bus to provide an output voltage equal to or greater than the input voltage. Since the DC-DC converter switches only a fraction of the power throughput, the overall system efficiency is very high. But this technique is limited to applications where the output is always greater than the input. The Series Connected Buck Boost Regulator (SCBBR) concept extends partial power processing technique used in the SCBU to operation when the desired output voltage is higher or lower than the input voltage, and the implementation described can even operate as a conventional buck converter to operate at very low output to input voltage ratios. This paper describes the operation and performance of an SCBBR configured as a bus voltage regulator providing 50 percent voltage regulation range, bus switching, and overload limiting, operating above 98 percent efficiency. The technique does not provide input-output isolation.

  12. Voltage Regulation by Phase Commutation Control Running On FPAA

    Ckristian. R. Durán-Blanco


    Full Text Available In this article we present a control scheme for triggering a SCR-based rectifier circuit. As implementation platform we use a field-programmable-analog-array device (FPAA that allows the development of algorithms for proportional, PID and sliding mode (SMC control techniques. Results show good performance of tested techniques to avoid effects of perturbations over the circuit load, by keeping regulated the output voltage. This suggests the potential use of the proposed technology for applications of reconfigurable hardware in power electronics.

  13. Small-signal, continuous, exact model of PWM voltage regulators

    Burkhardt, W.; Maranesi, P.; Varoli, V.


    The small-signal time-continuous open-loop response of buck, boost, and buck-boost pulse-width-modulation (PWM) voltage regulators using MOSFET switches in their power stages is modeled, applying a time-domain sampling theorem (Woodward, 1953) to obtain the Fourier open-loop transfer function corresponding to the comb function describing the response at the chopping instants only. The results are presented graphically along with simplified circuit diagrams of the PWM devices, and the accuracy and computational efficiency of the analytical approach are indicated.

  14. Index-based reactive power compensation scheme for voltage regulation

    Dike, Damian Obioma


    to optimal utilization of compensation devices and available transfer capability as well as reduce system outages through better regulation of power operating voltages.

  15. High voltage dc-dc converter with dynamic voltage regulation and decoupling during load-generated arcs

    Shimer, Daniel W.; Lange, Arnold C.


    A high-power power supply produces a controllable, constant high voltage output under varying and arcing loads. The power supply includes a voltage regulator, an inductor, an inverter for producing a high frequency square wave current of alternating polarity, an improved inverter voltage clamping circuit, a step up transformer, an output rectifier for producing a dc voltage at the output of each module, and a current sensor for sensing output current. The power supply also provides dynamic response to varying loads by controlling the voltage regulator duty cycle and circuitry is provided for sensing incipient arc currents at the output of the power supply to simultaneously decouple the power supply circuitry from the arcing load. The power supply includes a plurality of discrete switching type dc--dc converter modules.

  16. Fast Responding Voltage Regulator and Dynamic VAR Compensator

    Divan, Deepak [Varentec, Incorporated, San Jose, CA (United States); Moghe, Rohit [Varentec, Incorporated, San Jose, CA (United States); Tholomier, Damien [Varentec, Incorporated, San Jose, CA (United States)


    The objectives of this project were to develop a dynamic VAR compensator (DVC) for voltage regulation through VAR support to demonstrate the ability to achieve greater levels of voltage control on electricity distribution networks, and faster response compared to existing grid technology. The goal of the project was to develop a prototype Fast Dynamic VAR Compensator (Fast DVC) hardware device, and this was achieved. In addition to developing the dynamic VAR compensator device, Varentec in partnership with researchers at North Carolina State University (NCSU) successfully met the objectives to model the potential positive impact of such DVCs on representative power networks. This modeling activity validated the ability of distributed dynamic VAR compensators to provide fast voltage regulation and reactive power control required to respond to grid disturbances under high penetration of fluctuating and intermittent distributed energy resources (DERs) through extensive simulation studies. Specifically the following tasks were set to be accomplished: 1) Development of dynamic VAR compensator to support dynamic voltage variations on the grid through VAR control 2) Extensive testing of the DVC in the lab environment 3) Present the operational DVC device to the DOE at Varentec’s lab 4) Formulation of a detailed specification sheet, unit assembly document, test setup document, unit bring-up plan, and test plan 5) Extensive simulations of the DVC in a system with high PV penetration. Understanding the operation with many DVC on a single distribution system 6) Creation and submittal of quarterly and final reports conveying the design documents, unit performance data, modeling simulation charts and diagrams, and summary explanations of the satisfaction of program goals. This report details the various efforts that led to the development of the Fast DVC as well as the modeling & simulation results. The report begins with the introduction in Section II which outlines the


    Rowan, Matthew JM; Bulley, Simon; Purpura, Lauren; Ripps, Harris; Shen, Wen


    Taurine activates not only Cl−-permeable ionotropic receptors, but also receptors that mediate metabotropic responses. The metabotropic property of taurine was revealed in electrophysiological recordings obtained after fully blocking Cl−-permeable receptors with an inhibitory “cocktail” consisting of picrotoxin, SR95531, and strychnine. We found that taurine’s metabotropic effects regulate voltage-gated channels in retinal neurons. After applying the inhibitory cocktail, taurine enhanced delayed outward rectifier K+ channels preferentially in Off-bipolar cells, and the effect was completely blocked by the specific PKC inhibitor, GF109203X. Additionally, taurine also acted through a metabotropic pathway to suppress both L- and N-type Ca2+ channels in retinal neurons, which were insensitive to the potent GABAB receptor inhibitor, CGP55845. This study reinforces our previous finding that taurine in physiological concentrations produces a multiplicity of metabotropic effects that precisely govern the integration of signals being transmitted from the retina to the brain. PMID:23392926

  18. The Semiconductor Self-Excitation System of Synchronous Generator with Fuzzy Voltage Regulator

    Kutsyk, А.S.


    Full Text Available The synchronous generator’s voltage control system with the synthesized fuzzy voltage regulator is described. The synthesis of the regulator is carried out with the use of mathematical model taking into account the nonlinearity of synchronous machines and semiconductor converters in the e xcitation system. This distinguishes it from traditional excitation regulators, whose synthesis is based on the use of simplified linearized models. The mathematical modeling results allow to compare the control characteristics in the system with the proposed fuzzy voltage regulator and in the system with a traditional voltage controller.

  19. Voltage and Current Regulators Design of Power Converters in Islanded Microgrids based on State Feedback Decoupling

    Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Freijedo Fernandez, Francisco Daniel


    In stand-alone microgrids based on voltage source inverters state feedback coupling between the capacitor voltage and inductor current degrades significantly the dynamics performance of voltage and current regulators. The decoupling of the controlled states is proposed, considering the limitations...... introduced by system delays. Moreover, a proportional resonant voltage controller is designed according to Nyquist criterion taking into account application requirements. Experimental tests performed in compliance with the UPS standards verify the theoretical analysis....

  20. Transcriptional regulation of voltage-gated Ca(2+) channels.

    González-Ramírez, Ricardo; Felix, Ricardo


    The transcriptional regulation of voltage-gated Ca(2+) (CaV ) channels is an emerging research area that promises to improve our understanding of how many relevant physiological events are shaped in the central nervous system, the skeletal muscle, and other tissues. Interestingly, a picture of how transcription of CaV channel subunit genes is controlled is evolving with the identification of the promoter regions required for tissue-specific expression, and the identification of transcription factors that control their expression. These promoters share several characteristics that include multiple transcriptional start sites, lack of a TATA box, and the presence of elements conferring tissue-selective expression. Likewise, changes in CaV channel expression occur throughout development, following ischemia, seizures, or chronic drug administration. This review focuses on insights achieved regarding the control of CaV channel gene expression. To further understand the complexities of expression and to increase the possibilities of detecting CaV channel alterations causing human disease, a deeper knowledge on the structure of the 5' upstream regions of the genes encoding these remarkable proteins will be necessary. This article is protected by copyright. All rights reserved.

  1. Distributed Control to Ensure Proportional Load Sharing and Improve Voltage Regulation in Low-Voltage DC Microgrids

    Anand, Sandeep; G. Fernandes, Baylon; Guerrero, Josep M.


    DC microgrids are gaining popularity due to high efficiency, high reliability, and easy interconnection of renewable sources as compared to the ac system. Control objectives of dc microgrid are: 1) to ensure equal load sharing (in per unit) among sources; and 2) to maintain low-voltage regulation...

  2. A New Transformerless Single-Phase Buck-Boost AC Voltage Regulator

    YALCIN, F.


    Full Text Available Voltage regulation is one of the important goals for electrical sources and consumers. In this paper a new transformerless single-phase AC voltage regulator based on buck-boost converter topology is presented. The regulator circuit has a simple structure using only two bidirectional active switches, one inductor and one capacitor. A closed loop control system is implemented for the proposed regulator operation. A control law depending on the instantaneous values of the regulator's real input and desired output voltage is obtained and supports the PI controller. The control law allows the controller to obtain efficient pulse width modulation (PWM switching duty ratio for the desired output voltage when the input voltage has surges or fluctuations and the output load is changed. An experimental laboratory setup has been implemented for the proposed AC voltage regulator. The obtained results demonstrate that the proposed topology is capable of and efficient for both bucking and boosting the input AC voltage to a high quality output voltage with a low total harmonic distortion (THD for different input voltage and load conditions.

  3. Dynamic voltage regulation and power export in a distribution system using distributed generation

    Aamir HANIF; Muhammad Ahmed CHOUDHRY


    The major aim of power quality (PQ) enhancing techniques is to maintain a specified voltage magnitude at a desired frequency for sensitive loads irrespective of faults on the power distribution network. The dynamic voltage restorer (DVR) is a device used to mitigate voltage sags to regulate load voltage. This paper presents a mathematical model for leading series voltage injection to mitigate sags thereby achieving the improvement of the utility power factor as well as power sharing between the DVR and utility. The power sharing will be as per requirement to compensate the sags considering the available distributed generation (DG). The approach of mitigating voltage sags using the concept of leading series voltage injection is suitable for those locations where phase shift in the voltage will not cause any problem. The MATLAB/SIMULINK SimPowerSystem toolbox has been used to obtain simulation results to verify the proposed mathematical model.

  4. Implementation of a Capacitor Less Low Dropout Voltage Regulator on Chip (SOC

    Shailika Sharma


    Full Text Available — In this paper we have implemented a linear voltage low drop out regulator for efficient power management considering the fact in mind that voltage regulators provide a constant voltage supply to the circuits. We replace the common drain by common source pass element to improve efficiency and reduce the voltage drop across the device. This research paper includes the process to remove the external capacitor allowing for greater power system (soc application. A compensation scheme is presented that provides both a fast transient response and full range alternating current (ac stability from 0 to 50 mA load current even if the output load is as high as 100 pf. A 2.7-v capacitorless LDO voltage regulator with a power supply 3 v was designed with a dropout voltage of 300 mv.

  5. Comparison of resonant current regulators for DFIG during grid voltage distortion

    Yi-peng SONG; Heng NIAN


    We investigate two different kinds of resonant current regulators for a doubly fed induction generator (DFIG) under distorted grid voltage conditions:proportional integral resonant (PIR) regulator with traditional resonant part and vector propor-tional integral (VPI) regulator with VPI resonant part. Based on the mathematical model of DFIG under distorted grid voltage, the transfer function and frequency response characteristics of the two current regulators are analyzed and compared. The superiority of the VPI current regulator over the PIR regulator is pointed out, and the influence of discretization methods on the performance of the resonant current regulator is studied. All the results are validated by MATLAB simulation and experiments.

  6. Power flow control and voltage stability limit: regulating transformer versus UPFC

    Haque, M.H. [Nanyang Technological Univ., Center for Advanced Power Electronics, Nanyang (Singapore)


    Power flow through an AC transmission line can be controlled by injecting an adjustable compensating voltage in series with the line. This paper evaluates and compares the power flow control ranges of a simple system obtained by injecting an adjustable series compensating voltage produced by a regulating transformer and unified power flow controller. The static voltage stability limits of the system with a regulating transformer and unified power flow controller are also determined and compared. In evaluating the power flow control ranges and voltage stability limits, the transmission line of the system is modelled in four different ways. The results obtained for various line models are also compared. (Author)

  7. Efficient Low Voltage Amplification Using Self Starting Voltage Regulator for Storage System

    Haslinah Binti Mohd Nasir


    Full Text Available This paper presents a storage system design based on energy harvesting to achieve batteryless for Wireless Sensor Network (WSN application. The storage system is part of the Wireless Sensor Energy Harvesting to store and amplify the energy harvested from the surroundings. Finding a new sources of renewable energy has becomes a fashionable among researchers nowadays in particular harvesting the energy from the surrounding. However the challenge raised is to boost up the energy that known are very low. Thus the proposed method must be consumes very little power and suitable for ambient environmental sources such as vibration, wind and RF energy and be able to boost up the energy for storage system. The output of the harvested voltage is insufficient for most applications, therefore the system will boost up the input voltage level using DC to DC converter topology to higher dc voltage.The DC to DC converter shall be designed to suit the types of storage required. The output voltage of this DC converter should be sufficient to charge either capacitor or supercapacitor that will be use in this system as the energy storage system. The supercapacitor will provide power to energize any system such as in this case wireless sensor network[1]. In the case of wireless sensor network for example, the node would require the energy during transmitting and receiving data only whereas during standby mode or sleep mode, the amount of energy required would be very small[2]. Therefore the storage system will make use of this standby time or sleep mode of the sensor node to store as much energy as possible. The presented DC to DC converter in this paper has high efficiency upto 85.4% with input voltage between range 300mV to 600mV.

  8. Voltage Regulation and Line Loss Minimization of Loop Distribution Systems Using UPFC

    Sayed, Mahmoud A.; Takeshita, Takaharu

    This paper presents a new method for achieving line loss minimization and voltage regulation in the loop distribution systems, simultaneously. First, mathematical analysis of the line loss minimum conditions in the loop distribution systems is presented. Then, load voltage regulation is applied in the loop distribution system under line loss minimum condition. Reference angle of the desired load voltage is the main factor that can be used to minimize total line loss during load voltage control. In order to achieve these two objectives simultaneously, the UPFC (unified power flow controller), a typical FACTS (flexible AC transmission systems) device, that is capable of instantaneous control of transmission and distribution power flow, is used. Also, the UPFC control scheme to regulate the load voltage under line loss minimization is presented. The effectiveness of the proposed control scheme has been verified experimentally using laboratory prototype in a 200V, 6kVA system.

  9. Regulation of a lightweight high efficiency capacitator diode voltage multiplier dc-dc converter

    Harrigill, W. T., Jr.; Myers, I. T.


    A method for the regulation of a capacitor diode voltage multiplier dc-dc converter has been developed which has only minor penalties in weight and efficiency. An auxiliary inductor is used, which only handles a fraction of the total power, to control the output voltage through a pulse width modulation method in a buck boost circuit.

  10. Regulation of a lightweight high efficiency capacitor diode voltage multiplier dc-dc converter

    Harrigill, W. T., Jr.; Myers, I. T.


    A method for the regulation of a capacitor diode voltage multiplier dc-dc converter has been developed which has only minor penalties in weight and efficiency. An auxiliary inductor is used, which only handles a fraction of the total power, to control the output voltage through a pulse width modulation method in a buck boost circuit.

  11. PIP2 in pancreatic β-cells regulates voltage-gated calcium channels by a voltage-independent pathway.

    de la Cruz, Lizbeth; Puente, Erika I; Reyes-Vaca, Arturo; Arenas, Isabel; Garduño, Julieta; Bravo-Martínez, Jorge; Garcia, David E


    Phosphatidylinositol-4,5-bisphosphate (PIP2) is a membrane phosphoinositide that regulates the activity of many ion channels. Influx of calcium primarily through voltage-gated calcium (CaV) channels promotes insulin secretion in pancreatic β-cells. However, whether CaV channels are regulated by PIP2, as is the case for some non-insulin-secreting cells, is unknown. The purpose of this study was to investigate whether CaV channels are regulated by PIP2 depletion in pancreatic β-cells through activation of a muscarinic pathway induced by oxotremorine methiodide (Oxo-M). CaV channel currents were recorded by the patch-clamp technique. The CaV current amplitude was reduced by activation of the muscarinic receptor 1 (M1R) in the absence of kinetic changes. The Oxo-M-induced inhibition exhibited the hallmarks of voltage-independent regulation and did not involve PKC activation. A small fraction of the Oxo-M-induced CaV inhibition was diminished by a high concentration of Ca(2+) chelator, whereas ≥50% of this inhibition was prevented by diC8-PIP2 dialysis. Localization of PIP2 in the plasma membrane was examined by transfecting INS-1 cells with PH-PLCδ1, which revealed a close temporal association between PIP2 hydrolysis and CaV channel inhibition. Furthermore, the depletion of PIP2 by a voltage-sensitive phosphatase reduced CaV currents in a way similar to that observed following M1R activation. These results indicate that activation of the M1R pathway inhibits the CaV channel via PIP2 depletion by a Ca(2+)-dependent mechanism in pancreatic β- and INS-1 cells and thereby support the hypothesis that membrane phospholipids regulate ion channel activity by interacting with ion channels.

  12. Calcium binding protein-mediated regulation of voltage-gated calcium channels linked to human diseases

    Nasrin NFJATBAKHSH; Zhong-ping FENG


    Calcium ion entry through voltage-gated calcium channels is essential for cellular signalling in a wide variety of cells and multiple physiological processes. Perturbations of voltage-gated calcium channel function can lead to pathophysiological consequences. Calcium binding proteins serve as calcium sensors and regulate the calcium channel properties via feedback mechanisms. This review highlights the current evidences of calcium binding protein-mediated channel regulation in human diseases.

  13. Incentive-Based Voltage Regulation in Distribution Networks

    Dall-Anese, Emiliano [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Baker, Kyri A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Zhou, Xinyang [University of Colorado; Chen, Lijun [University of Colorado


    This paper considers distribution networks fea- turing distributed energy resources, and designs incentive-based mechanisms that allow the network operator and end-customers to pursue given operational and economic objectives, while concurrently ensuring that voltages are within prescribed limits. Two different network-customer coordination mechanisms that require different amounts of information shared between the network operator and end-customers are developed to identify a solution of a well-defined social-welfare maximization prob- lem. Notably, the signals broadcast by the network operator assume the connotation of prices/incentives that induce the end- customers to adjust the generated/consumed powers in order to avoid the violation of the voltage constraints. Stability of the proposed schemes is analytically established and numerically corroborated.

  14. Incentive-Based Voltage Regulation in Distribution Networks: Preprint

    Zhou, Xinyang; Chen, Lijun; Dall' Anese, Emiliano; Baker, Kyri


    This paper considers distribution networks fea- turing distributed energy resources, and designs incentive-based mechanisms that allow the network operator and end-customers to pursue given operational and economic objectives, while concurrently ensuring that voltages are within prescribed limits. Two different network-customer coordination mechanisms that require different amounts of information shared between the network operator and end-customers are developed to identify a solution of a well-defined social-welfare maximization prob- lem. Notably, the signals broadcast by the network operator assume the connotation of prices/incentives that induce the end- customers to adjust the generated/consumed powers in order to avoid the violation of the voltage constraints. Stability of the proposed schemes is analytically established and numerically corroborated.

  15. Short-Term State Forecasting-Based Optimal Voltage Regulation in Distribution Systems: Preprint

    Yang, Rui; Jiang, Huaiguang; Zhang, Yingchen


    A novel short-term state forecasting-based optimal power flow (OPF) approach for distribution system voltage regulation is proposed in this paper. An extreme learning machine (ELM) based state forecaster is developed to accurately predict system states (voltage magnitudes and angles) in the near future. Based on the forecast system states, a dynamically weighted three-phase AC OPF problem is formulated to minimize the voltage violations with higher penalization on buses which are forecast to have higher voltage violations in the near future. By solving the proposed OPF problem, the controllable resources in the system are optimally coordinated to alleviate the potential severe voltage violations and improve the overall voltage profile. The proposed approach has been tested in a 12-bus distribution system and simulation results are presented to demonstrate the performance of the proposed approach.

  16. Low-frequency switching voltage regulators for terrestrial photovoltaic systems

    Delombard, R.


    The photovoltaic technology project and the stand alone applications project are discussed. Two types of low frequency switching type regulators were investigated. The design, operating characteristics and field application of these regulators is described. The regulators are small in size, low in cost, very low in power dissipation, reliable and allow considerable flexibility in system design.

  17. Voltage regulation and reactive power supply capability of distributed generation : applications in active distribution systems

    Katiraei, F.; Yazdani, A.; Uluski, R. [Quanta Technology, New York, NY (United States); Vaziri, M. [Pacific Gas and Electric Co., San Fransisco, CA (United States)


    Problems regarding voltage regulation on distribution feeders arise when there is a large demand for reactive power. The addition of distributed generation changes the power flow and voltage profile of a power system. The current practice is to use distributed generation passively and perform voltage regulation as before. However, this may not function well with high distributed generation penetration. This presentation discussed voltage regulation and the reactive power supply capability of distributed generation. Several applications in active distribution systems were presented. Specifically, the presentation discussed distributed interconnection challenges; utility practices and limiting factors; and the real and reactive power capabilities of distributed generation. A case study was also presented. It was concluded that in order for distributed generation to actively participate in real and reactive power management of distribution systems, a change is needed in standards and utility guidelines, along with a better understanding of distributed generation technologies and controls. 1 tab., 11 figs.

  18. Low drop-out voltage regulator as a candidate topology for photovoltaic solar facilities

    Martínez García, Herminio


    This article aims to present the design of a 4.5-V, 450-mA low drop-out (LDO) voltage linear regulator based on a two-stage cascoded operational transconductance amplifier (OTA) as error amplifier for photovoltaic solar DC-DC regulation. The aforementioned two-stage OTA is designed with cascoded current mirroring technique to boost up the output impedance. The proposed OTA has a DC gain of 101 dB under no load condition. The designed reference voltage included in the LDO regulator is provi...

  19. An Optimal Control Strategy for DC Bus Voltage Regulation in Photovoltaic System with Battery Energy Storage

    Muhamad Zalani Daud


    Full Text Available This paper presents an evaluation of an optimal DC bus voltage regulation strategy for grid-connected photovoltaic (PV system with battery energy storage (BES. The BES is connected to the PV system DC bus using a DC/DC buck-boost converter. The converter facilitates the BES power charge/discharge to compensate for the DC bus voltage deviation during severe disturbance conditions. In this way, the regulation of DC bus voltage of the PV/BES system can be enhanced as compared to the conventional regulation that is solely based on the voltage-sourced converter (VSC. For the grid side VSC (G-VSC, two control methods, namely, the voltage-mode and current-mode controls, are applied. For control parameter optimization, the simplex optimization technique is applied for the G-VSC voltage- and current-mode controls, including the BES DC/DC buck-boost converter controllers. A new set of optimized parameters are obtained for each of the power converters for comparison purposes. The PSCAD/EMTDC-based simulation case studies are presented to evaluate the performance of the proposed optimized control scheme in comparison to the conventional methods.

  20. An optimal control strategy for DC bus voltage regulation in photovoltaic system with battery energy storage.

    Daud, Muhamad Zalani; Mohamed, Azah; Hannan, M A


    This paper presents an evaluation of an optimal DC bus voltage regulation strategy for grid-connected photovoltaic (PV) system with battery energy storage (BES). The BES is connected to the PV system DC bus using a DC/DC buck-boost converter. The converter facilitates the BES power charge/discharge to compensate for the DC bus voltage deviation during severe disturbance conditions. In this way, the regulation of DC bus voltage of the PV/BES system can be enhanced as compared to the conventional regulation that is solely based on the voltage-sourced converter (VSC). For the grid side VSC (G-VSC), two control methods, namely, the voltage-mode and current-mode controls, are applied. For control parameter optimization, the simplex optimization technique is applied for the G-VSC voltage- and current-mode controls, including the BES DC/DC buck-boost converter controllers. A new set of optimized parameters are obtained for each of the power converters for comparison purposes. The PSCAD/EMTDC-based simulation case studies are presented to evaluate the performance of the proposed optimized control scheme in comparison to the conventional methods.

  1. Effect of Solar Array Capacitance on the Performance of Switching Shunt Voltage Regulator

    Kumar, Anil R; Suresh, MS; Nagaraju, J


    Due to high power demand photovoltaic regulators are being switched at high frequency. The solar cell capacitance increases the ripple voltage of the switching regulators at higher switching frequencies. Increased ripple due to array capacitance is calculated and its effect in limiting the maximum design switching frequency is studied. An experimental switching regulator is designed and used to confirm the theoretical considerations. This study has identified a method of solar cell capacitanc...

  2. Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).

    Rodríguez-Menchaca, Aldo A; Adney, Scott K; Zhou, Lei; Logothetis, Diomedes E


    Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidylinositol 4,5-bisphosphate (PIP(2)). Among them are voltage-gated channels, which are crucial for both neuronal and cardiac excitability. Voltage-gated calcium (Cav) channels were shown to be regulated bidirectionally by PIP(2). On one hand, PIP(2) stabilized their activity by reducing current rundown but on the other hand it produced a voltage-dependent inhibition by shifting the activation curve to more positive voltages. For voltage-gated potassium (Kv) channels PIP(2) was first shown to prevent N-type inactivation regardless of whether the fast inactivation gate was part of the pore-forming α subunit or of an accessory β subunit. Careful examination of the effects of PIP(2) on the activation mechanism of Kv1.2 has shown a similar bidirectional regulation as in the Cav channels. The two effects could be distinguished kinetically, in terms of their sensitivities to PIP(2) and by distinct molecular determinants. The rightward shift of the Kv1.2 voltage dependence implicated basic residues in the S4-S5 linker and was consistent with stabilization of the inactive state of the voltage sensor. A third type of a voltage-gated ion channel modulated by PIP(2) is the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel. PIP(2) has been shown to enhance the opening of HCN channels by shifting their voltage-dependent activation toward depolarized potentials. The sea urchin HCN channel, SpIH, showed again a PIP(2)-mediated bidirectional effect but in reverse order than the depolarization-activated Cav and Kv channels: a voltage-dependent potentiation, like the mammalian HCN channels, but also an inhibition of the cGMP-induced current activation. Just like the Kv1.2 channels, distinct molecular determinants underlied the PIP(2) dual effects on SpIH, with the proximal C-terminus implicated in the

  3. Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

    Aldo A Rodríguez Menchaca


    Full Text Available Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2. Among them are voltage-gated channels, which are crucial for both neuronal and cardiac excitability. Voltage-gated calcium (Cav channels were shown to be regulated bidirectionally by PIP2. On one hand, PIP2 stabilized their activity by reducing current rundown but on the other hand it produced a voltage-dependent inhibition by shifting the activation curve to more positive voltages. For voltage-gated potassium (Kv channels PIP2 was first shown to prevent N-type inactivation. Careful examination of the effects of PIP2 on the activation mechanism of Kv1.2 has shown a similar bidirectional regulation as in the Cav channels. The two effects could be distinguished kinetically, in terms of their sensitivities to PIP2 and by distinct molecular determinants. The rightward shift of the Kv1.2 voltage dependence implicated basic residues in the S4-S5 linker and was consistent with stabilization of the inactive state of the voltage sensor. A third type of a voltage-gated ion channel modulated by PIP2 is the hyperpolarization-activated cyclic nucleotide-gated (HCN channel. PIP2 has been shown to enhance the opening of HCN channels by shifting their voltage-dependent activation toward depolarized potentials. The sea urchin HCN channel, SpIH, showed again a PIP2-mediated bidirectional effect but in reverse order than the depolarization-activated Cav and Kv channels: a voltage-dependent potentiation, like the mammalian HCN channels, but also an inhibition of the cGMP-induced current activation. Just like the Kv1.2 channels, distinct molecular determinants underlied the PIP2 dual effects on SpIH channels. The dual regulation of these very different ion channels, all of which are voltage dependent, points to conserved mechanisms of regulation of these channels by PIP2.

  4. Impact of wind farms voltage regulation on the stability of the network frequency

    Fernandez, R.D. [Laboratorio de Electronica Industrial, Control e Instrumentacion (LEICI), Facultad de Ingenieria, Universidad Nacional de La Plata, CC 91, 1900 La Plata (Argentina); Laboratorio de Electronica. Facultad de Ingenieria, Universidad Nacional de la Patagonia San Juan Bosco, Ciudad Universitaria, Km. 4, 9000 Comodoro Rivadavia (Argentina); Battaiotto, P.E.; Mantz, R.J. [Laboratorio de Electronica Industrial, Control e Instrumentacion (LEICI), Facultad de Ingenieria, Universidad Nacional de La Plata, CC 91, 1900 La Plata (Argentina)


    As it is well known, different kinds of wind farms can contribute to frequency and voltage regulation by means of active and reactive powers, respectively. This paper analyzes how the wind farm reactive power loop, which contribute to voltage regulation, modifies the location of the eigenvalues of a selected power system when the wind power penetration is increased. Previous to this analysis, aspects of the modeling of double fed induction generators in wind energy generation and power systems are discussed. Finally, simulations, which verify the theoretical results are presented. (author)

  5. Voltage regulation in LV grids by coordinated volt-var control strategies

    Juamperez Goñi, Miguel Angel; Yang, Guangya; Kjær, Søren Bækhøj


    in terms of network power losses and voltage level along the feeder. As a practical implementation, a reconfigurable hardware is used for developing a testing platform based on real-time measurements to regulate the reactive power level. The proposed testing platform has been developed within PVNET......The increasing penetration level of photovoltaic (PV) power generation in low voltage (LV) networks results in voltage rise issues, particularly at the end of the feeders. In order to mitigate this problem, several strategies, such as grid reinforcement, transformer tap change, demand......-side management, active power curtailment, and reactive power optimization methods, show their contribution to voltage support, yet still limited. This paper proposes a coordinated volt-var control architecture between the LV distribution transformer and solar inverters to optimize the PV power penetration level...

  6. Voltage regulation in MV networks with dispersed generations by a neural-based multiobjective methodology

    Galdi, Vincenzo [Dipartimento di Ingegneria dell' Informazione e Ingegneria Elettrica, Universita degli studi di Salerno, Via Ponte Don Melillo 1, 84084 Fisciano (Italy); Vaccaro, Alfredo; Villacci, Domenico [Dipartimento di Ingegneria, Universita degli Studi del Sannio, Piazza Roma 21, 82100 Benevento (Italy)


    This paper puts forward the role of learning techniques in addressing the problem of an efficient and optimal centralized voltage control in distribution networks equipped with dispersed generation systems (DGSs). The proposed methodology employs a radial basis function network (RBFN) to identify the multidimensional nonlinear mapping between a vector of observable variables describing the network operating point and the optimal set points of the voltage regulating devices. The RBFN is trained by numerical data generated by solving the voltage regulation problem for a set of network operating points by a rigorous multiobjective solution methodology. The RBFN performance is continuously monitored by a supervisor process that notifies when there is the need of a more accurate solution of the voltage regulation problem if nonoptimal network operating conditions (ex post monitoring) or excessive distances between the actual network state and the neuron's centres (ex ante monitoring) are detected. A more rigorous problem solution, if required, can be obtained by solving the voltage regulation problem by a conventional multiobjective optimization technique. This new solution, in conjunction with the corresponding input vector, is then adopted as a new train data sample to adapt the RBFN. This online training process allows RBFN to (i) adaptively learn the more representative domain space regions of the input/output mapping without needing a prior knowledge of a complete and representative training set, and (ii) manage effectively any time varying phenomena affecting this mapping. The results obtained by simulating the regulation policy in the case of a medium-voltage network are very promising. (author)

  7. LED Current Balance Using a Variable Voltage Regulator with Low Dropout vDS Control

    Hung-I Hsieh


    Full Text Available A cost-effective light-emitting diode (LED current balance strategy using a variable voltage regulator (VVR with low dropout vDS control is proposed. This can regulate the multiple metal-oxide-semiconductor field-effect transistors (MOSFETs of the linear current regulators (LCR, maintaining low dropout vDS on the flat vGS-characteristic curves and making all drain currents almost the same. Simple group LCRs respectively loaded with a string LED are employed to implement the theme. The voltage VVdc from a VVR is synthesized by a string LED voltage NvD, source voltage vR, and a specified low dropout vDS = VQ. The VVdc updates instantly, through the control loop of the master LCR, which means that all slave MOSFETs have almost the same biases on their flat vGS-characteristic curves. This leads to all of the string LED currents being equal to each other, producing an almost even luminance. An experimental setup with microchip control is built to verify the estimations. Experimental results show that the luminance of all of the string LEDs are almost equal to one another, with a maximum deviation below 1% during a wide dimming range, while keeping all vDS of the MOSFETs at a low dropout voltage, as expected.

  8. Modeling and Verification of Distributed Generation and Voltage Regulation Equipment for Unbalanced Distribution Power Systems; Annual Subcontract Report, June 2007

    Davis, M. W.; Broadwater, R.; Hambrick, J.


    This report summarizes the development of models for distributed generation and distribution circuit voltage regulation equipment for unbalanced power systems and their verification through actual field measurements.

  9. T-type voltage-gated calcium channels regulate the tone of mouse efferent arterioles

    Poulsen, Christian B; Al-Mashhadi, Rozh H; Cribbs, Leanne L;


    Voltage-gated calcium channels are important for the regulation of renal blood flow and the glomerular filtration rate. Excitation-contraction coupling in afferent arterioles is known to require activation of these channels and we studied their role in the regulation of cortical efferent arteriolar...... tone. We used microdissected perfused mouse efferent arterioles and found a transient vasoconstriction in response to depolarization with potassium; an effect abolished by removal of extracellular calcium. The T-type voltage-gated calcium channel antagonists mibefradil and nickel blocked this potassium....... Low concentrations of nickel, an agent that blocks Ca(v)3.2, had a similar effect. Thus, T-type voltage-gated calcium channels are functionally important for depolarization-induced vasoconstriction and subsequent dilatation in mouse cortical efferent arterioles.Kidney International advance online...

  10. An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels.

    Onwuli, Donatus O; Beltran-Alvarez, Pedro


    Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (NaV1.1), SCN2A (NaV1.2), SCN3A (NaV1.3) and SCN8A (NaV1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.

  11. A Low-Dropout Voltage Regulator with a Fractional-Order Control

    L. Kadlcik


    Full Text Available This paper presents a 5 V / 50 mA low-dropout voltage regulator (LDO. The LDO uses a fractional-order control for its regulation loop to achieve a high DC gain (for a tight DC regulation while avoiding (for a good stability a high gain at high frequency. No compensation zeros are needed. The unity gain frequency of the regulation loop also changes adaptively with the output current to maintain it below the frequency of non-dominant poles. The LDO is stable with any external capacitance larger than 50 nF, and is expected to operate in a harsh automotive environment, with junction temperature ranging from -40°C to 170°C and with supply voltage from 7 V to 36 V. The operation of the LDO has been verified by realizing it in the 350 nm I3T50 ON Semiconductor technology.

  12. The enhanced low dose rate sensitivity of a linear voltage regulator with different biases

    Wang Yiyuan; Lu Wu; Ren Diyuan; Guo Qi; Yu Xuefeng; Gao Bo


    A linear voltage regulator was irradiated by 60Co γ at high and low dose rates with two bias conditions to investigate the dose rate effect.The devices exhibit enhanced low dose rate sensitivity (ELDRS) under both biases.Comparing the enhancement factors between zero and working biases,it was found that the ELDRS is more severe under zero bias conditions.This confirms that the ELDRS is related to the low electric field in a bipolar structure.The reasons for the change in the line regulation and the maximum drive current were analyzed by combining the principle of linear voltage regulator with irradiation response of the transistors and error amplifier in the regulator.This may be helpful for designing radiation hardened devices.

  13. A Price-Based Approach for Voltage Regulation and Power Loss Minimization in Power Distribution Networks

    Jafarian, Matin; Scherpen, Jacquelien M.A.; Aiello, Marco


    We present a price-based approach to deal with the challenges of the electrical power distribution systems with renewable generations. In specific, we address the power loss minimization and voltage regulation taking into account the actual grid capacity. Analogously, the cost function is reformulat

  14. Power lateral pnp transistor operating with high current density in irradiated voltage regulator

    Vukić Vladimir Đ.


    Full Text Available The operation of power lateral pnp transistors in gamma radiation field was examined by detection of the minimum dropout voltage on heavily loaded low-dropout voltage regulators LM2940CT5, clearly demonstrating their low radiation hardness, with unacceptably low values of output voltage and collector-emitter voltage volatility. In conjunction with previous results on base current and forward emitter current gain of serial transistors, it was possible to determine the positive influence of high load current on a slight improvement of voltage regulator LM2940CT5 radiation hardness. The high-current flow through the wide emitter aluminum contact of the serial transistor above the isolation oxide caused intensive annealing of the positive oxide-trapped charge, leading to decrease of the lateral pnp transistor's current gain, but also a more intensive recovery of the small-signal npn transistors in the control circuit. The high current density in the base area of the lateral pnp transistor immediately below the isolation oxide decreased the concentration of negative interface traps. Consequently, the positive influence of the reduced concentration of the oxide-trapped charge on the negative feedback reaction circuit, together with the favourable effect of reduced interface traps concentration, exceeded negative influence of the annealed oxide-trapped charge on the serial pnp transistor's forward emitter current gain.

  15. Regulation of voltage gated calcium channels by GPCRs and post-translational modification.

    Huang, Junting; Zamponi, Gerald W


    Calcium entry via voltage gated calcium channels mediates a wide range of physiological functions, whereas calcium channel dysregulation has been associated with numerous pathophysiological conditions. There are myriad cell signaling pathways that act on voltage gated calcium channels to fine tune their activities and to regulate their cell surface expression. These regulatory mechanisms include the activation of G protein-coupled receptors and downstream phosphorylation events, and their control over calcium channel trafficking through direct physical interactions. Calcium channels also undergo post-translational modifications that alter both function and density of the channels in the plasma membrane. Here we focus on select aspects of these regulatory mechanisms and highlight recent developments.

  16. Synchronous Generator Model with Fractional Order Voltage Regulator PIbDa

    Dariusz Spałek


    Full Text Available Synchronous generator together with excitation circuit, voltage controller and system stabilizer constitute nonlinear ordinary differential equations set. The nonlinearity of differential equations set results from magnetic circuits saturation. One of the most important, from the electric energy distribution point of view, is the influence of voltage control applied on the generator voltage. There could be applied regulator either classical PID or fractional of type PIbDa which bases on the so-called fractional derivative idea. Numerical solutions of nonlinear differential equations set, that takes into account both magnetic circuits saturation and fractional regulator PIbDa, lead to decisions either to accept or to reject the chosen parameters. The sensibility of generator work on chosen fractional regulator parameters is the main aim of this paper. With the help of C++ program provided the most important states of work (short–circuit, setting voltage change, reactive power rejection can be analyzed basing on the accepted model of synchronous generator such as (1,1, (2,2 or (3,3.

  17. Radial MV networks voltage regulation with distribution management system coordinated controller

    Bignucolo, Fabio; Caldon, Roberto [University of Padua, Department of Electrical Engineering, Via Gradenigo, 6/A, 35131 Padova (Italy); Prandoni, Valter [CESI Ricerca, Milan (Italy)


    The connection of a great number of distributed generation (DG) plants may cause a critical voltage regulation problem in actual medium voltage (MV) radial distribution networks. After a synthetic survey of different strategies reported in literature to solve this problem, a proposal for an active management of the distribution system which makes use of an innovative controller that coordinates the on load tap changer (OLTC) action with the regulation of reactive exchanges between DG plants and feeders, is presented. In order to test the effectiveness of the proposed regulation, the distribution management system coordinated controller (DMSCC) is applied to a realistic radial structure distribution network and its behaviour simulated in managing the MV system during its worst foreseeable working conditions. (author)

  18. Endocytic regulation of voltage-dependent potassium channels in the heart.

    Ishii, Kuniaki; Norota, Ikuo; Obara, Yutaro


    Understanding the regulation of cardiac ion channels is critical for the prevention of arrhythmia caused by abnormal excitability. Ion channels can be regulated by a change in function (qualitative) and a change in number (quantitative). Functional changes have been extensively investigated for many ion channels including cardiac voltage-dependent potassium channels. By contrast, the regulation of ion channel numbers has not been widely examined, particularly with respect to acute modulation of ion channels. This article briefly summarizes stimulus-induced endocytic regulation of major voltage-dependent potassium channels in the heart. The stimuli known to cause their endocytosis include receptor activation, drugs, and low extracellular [K(+)], following which the potassium channels undergo either clathrin-mediated or caveolin-mediated endocytosis. Receptor-mediated endocytic regulation has been demonstrated for Kv1.2, Kv1.5, KCNQ1 (Kv7.1), and Kv4.3, while drug-induced endocytosis has been demonstrated for Kv1.5 and hERG. Low [K(+)](o)-induced endocytosis might be unique for hERG channels, whose electrophysiological characteristics are known to be under strong influence of [K(+)](o). Although the precise mechanisms have not been elucidated, it is obvious that major cardiac voltage-dependent potassium channels are modulated by endocytosis, which leads to changes in cardiac excitability.

  19. Output voltage regulation of a k15 mode piezoelectric transformer by an external L/C component.

    Hu, Junhui; Chan, Kuang Hwee; Ng, Boon Siang


    Smooth regulation of output voltage of piezoelectric transformers can significantly widen the application range of piezoelectric transformers. So far the driving frequency of piezoelectric transformers has been used to regulate the output voltage at a matching load. However, the regulation range of voltage gain achieved by the method is usually very narrow within the acceptable range of efficiency. In this work, we investigate the possibility to regulate the output voltage of a k15 mode piezoelectric transformer by an external L/C component. The effects of an L/C component in series or parallel with the input and output ports on the voltage gain are investigated theoretically and experimentally. It is found that the voltage gain can be smoothly regulated in a relatively wide range by a tunable inductor that is in series with the input port. At a matching load of 80 Omega, the voltage gain can be regulated between 0.31 and 0.94 with efficiency larger than 90% and between 0.34 and 1.18 with efficiency about 80%. It is also found that a tunable capacitor in parallel or series with the output port can be used to regulate the voltage gain with efficiency higher than 90%.

  20. A Smart Load Interface and Voltage Regulator for Electrostatic Vibration Energy Harvester

    Bedier, Mohammed; Basset, Philippe; Galayko, Dimitri


    This paper presents a new implementation in ams 0.35μm HV technology of a complete energy management system for an electrostatic vibrational energy harvester (e-VEH). It is based on the Bennet's doubler architecture and includes a load voltage regulator (LVR) and a smart Load Interface (LI) that are self-controlled with internal voltages for maximum power point tracking (MMPT). The CMOS implementation makes use of an energy harvester that is capable of producing up to 1.8μW at harmonic excitation, given its internal voltage is kept within its optimum. An intermediate LI stage and its controller makes use of a high side switch with zero static power level shifter, and a low power hysteresis comparator. A full circuit level simulation with a VHDL-AMS model of the e-VEH presented was successfully achieved, indicating that the proposed load interface controller consumes less than 100nW average power. Moreover, a LVR regulates the buffer and discharge the harvested energy into a generic resistive load maintaining the voltage within a nominal value of 2 Volts.

  1. Microloss DC Voltage Regulator%微功耗直流稳压器



    The voltage interception and voltage compensation was employed to stabilize or regulate DC voltage, whose distinguished characteristic is that the core 'circuit could avoid the electro-magnetic interferences (EMI) to the grid for no use of pulse-width modulation (PWM). Therefore its power consumption is kept as low as possible while its lifetime can be as long as possible with an efficiency as high as 99.5%. Moreover, it is safe and reliable, green and energy-conserving and its simple circuit is easy to fabricate. Its cost, volume, weight, and power consumption are about only ten percent of those of the traditional DC voltage regulators.%微功耗直流稳压器采用电压切割和电压补偿的方法,实现了对直流电压的稳定或调整,该直流稳压器最大特点是,主电路不采用PWM脉宽调制,不产生EMI干扰,因此功耗极小而寿命极长,输出直流电压调整率高,效率高达99.5%,安全可靠,节能环保,电路简单,制作安装容易,其成本、体积、重量、功耗都是传统直流稳压器的十分之一。

  2. Regulation of Na(+) channel inactivation by the DIII and DIV voltage-sensing domains.

    Hsu, Eric J; Zhu, Wandi; Schubert, Angela R; Voelker, Taylor; Varga, Zoltan; Silva, Jonathan R


    Functional eukaryotic voltage-gated Na(+) (NaV) channels comprise four domains (DI-DIV), each containing six membrane-spanning segments (S1-S6). Voltage sensing is accomplished by the first four membrane-spanning segments (S1-S4), which together form a voltage-sensing domain (VSD). A critical NaV channel gating process, inactivation, has previously been linked to activation of the VSDs in DIII and DIV. Here, we probe this interaction by using voltage-clamp fluorometry to observe VSD kinetics in the presence of mutations at locations that have been shown to impair NaV channel inactivation. These locations include the DIII-DIV linker, the DIII S4-S5 linker, and the DIV S4-S5 linker. Our results show that, within the 10-ms timeframe of fast inactivation, the DIV-VSD is the primary regulator of inactivation. However, after longer 100-ms pulses, the DIII-DIV linker slows DIII-VSD deactivation, and the rate of DIII deactivation correlates strongly with the rate of recovery from inactivation. Our results imply that, over the course of an action potential, DIV-VSDs regulate the onset of fast inactivation while DIII-VSDs determine its recovery.

  3. Fully on-chip switched capacitor NMOS low dropout voltage regulator

    Camacho, D; Camacho, Daniel; Moreira, Paulo


    This paper presents a 1.5 V 50 mA low dropout voltage (LDO) regulator using an NMOS transistor as the output pass element. Continuous time,operation of the LDO is achieved using a new switched floating capacitor scheme that raises the gate voltage of the pass element. The regulator has a 0.2 V dropout at a 50 mA load and is stable for a wide load current range with loading capacitances up to 50 pF. The output variation when a full load step is applied is 300 mV and the recovery time is below 0.3 mu s. it is designed in a 0.13 mu m CMOS process with an area of 0.008 mm(2) and its operation does not require any external component.

  4. Comparing and evaluating the voltage regulation of a UPFC and STATCOM

    Al-Mawsawi, S.A. [University of Bahrain (Bahrain). College of Engineering


    In recent years it has been illustrated that the installation position of a Unified power flow controller (UPFC) has an important effect on its overall performance. A pulse width modulation (PWM) based UPFC used as a voltage regulator is modeled and analyzed to investigate its optimal position in the transmission line. This is compared with STATic COMpensator (STATCOM) device. This paper deals with the definition and simulation of the steady-state performance of the UPFC and STATCOM when they operate as a terminal voltage regulator. From the simulation results it is demonstrated that by varying the modulation index of the two devices it can control the distribution of active and reactive power flows. Furthermore, the comparisons for the optimum operation for the two devices have been performed. (author)


    J.V. Kovalova


    Full Text Available A model for a separation of reactive constituent from current of idling of an induction motor at its feed from a thyristor voltage regulator in the dependences on the control angle of thyristors is developed. As a result of modeling, dependence of relative reactive current which is approximated by formula for calculation of effective current of reactive constituent of nonsinusoidal current is obtained.

  6. High-efficiency voltage regulator and stabilizer for outdoor lighting installations

    Blánquez, F.R.; Rebollo López, Emilio; Blázquez García, Francisco; Platero Gaona, Carlos Antonio; Frías Marín, Pablo


    This paper presents a high performance system of regulation and stabilization of luminous flux for public street lighting installations. Its purpose is to reduce the luminous flux of the luminaries efficiently by reducing their voltage supply, resulting in the improvement of energy efficiency in the installation. The system is basically composed of electromagnetic components which provide robustness and high-performance to the device, as well as minimum maintenance requirements. However, the ...

  7. Voltage Regulation Using a Permanent Magnet Synchronous Generator with a Series Compensator: Preprint

    Hsu, Ping; Wu, Ziping; Muljadi, Eduard; Gao, Wenzhong


    A wind power plant (WPP) is often operated at unity power factor, and the utility host where the WPP connects prefers to regulate the voltage. Although this may not be an issue in a stiff grid, the connection to a weak grid can be a problematic. This paper explores the advantages of having voltage regulation capability via reactive power control. Another issue in wind power generation is that not all turbines are able to control their reactive power due to technical reasons or contractual obligations. A synchronous condenser (SC) using a permanent magnet synchronous generator (PMSG) is proposed to provide necessary reactive power for regulating voltage at a weak grid connection. A PMSG has the advantage of higher efficiency and reliability. Because of its lack of a field winding, a PMSG is typically controlled by a full-power converter, which can be costly. In the proposed system, the reactive power of the SC is controlled by a serially connected compensator operating in a closed-loop configuration. The compensator also damps the PMSG’s tendency to oscillate. The compensator’s VA rating is only a fraction of the rating of the SC and the PMSG. In this initial investigation, the proposed scheme is shown to be effective by computer simulations.

  8. Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells.

    Yoshida, Masashi; Nakata, Masanori; Yamato, Shiho; Dezaki, Katsuya; Sugawara, Hitoshi; Ishikawa, San-e; Kawakami, Masanobu; Yada, Toshihiko; Kakei, Masafumi


    Voltage-gated potassium channels (Kv channels) play a crucial role in formation of action potentials in response to glucose stimulation in pancreatic beta-ells. We previously reported that the Kv channel is regulated by glucose metabolism, particularly by MgATP. We examined whether the regulation of Kv channels is voltage-dependent and mechanistically related with phosphorylation of the channels. In rat pancreatic beta-cells, suppression of glucose metabolism with low glucose concentrations of 2.8mM or less or by metabolic inhibitors decreased the Kv2.1-channel activity at positive membrane potentials, while increased it at potentials negative to -10 mV, suggesting that modulation of Kv channels by glucose metabolism is voltage-dependent. Similarly, in HEK293 cells expressing the recombinant Kv2.1 channels, 0mM but not 10mM MgATP modulated the channel activity in a manner similar to that in beta-cells. Both steady-state activation and inactivation kinetics of the channel were shifted toward the negative potential in association with the voltage-dependent modulation of the channels by cytosolic dialysis of alkaline phosphatase in beta-cells. The modulation of Kv-channel current-voltage relations were also observed during and after glucose-stimulated electrical excitation. These results suggest that the cellular metabolism including MgATP production and/or channel phosphorylation/dephosphorylation underlie the physiological modulation of Kv2.1 channels during glucose-induced insulin secretion.

  9. Distributed Control of Battery Energy Storage Systems for Voltage Regulation in Distribution Networks with High PV Penetration

    Zeraati, Mehdi; Golshan, Mohamad Esmaeil Hamedani; Guerrero, Josep M.


    issues of distribution networks. In this paper, the battery energy storage (BES) systems are used in order to solve the voltage rise during the peak PV generation as well as the voltage drop while meeting the peak load. A coordinated control strategy is proposed to regulate the charge/discharge of BESs...... using a combination of the local droop based control method and a distributed control scheme which ensures the voltages of feeder remain within allowed limits. Therefore, two different consensus algorithms are used: The first algorithm determines the BESs participation in voltage regulation in terms......The voltage rise problem in low voltage (LV) distribution networks with high penetration of photovoltaic (PV) resources is one of the most important challenges in the development of these renewable resources since it may prevent the maximum PV penetration considering the reliability and security...

  10. Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels.

    Castillo, Karen; Contreras, Gustavo F; Pupo, Amaury; Torres, Yolima P; Neely, Alan; González, Carlos; Latorre, Ramon


    Being activated by depolarizing voltages and increases in cytoplasmic Ca(2+), voltage- and calcium-activated potassium (BK) channels and their modulatory β-subunits are able to dampen or stop excitatory stimuli in a wide range of cellular types, including both neuronal and nonneuronal tissues. Minimal alterations in BK channel function may contribute to the pathophysiology of several diseases, including hypertension, asthma, cancer, epilepsy, and diabetes. Several gating processes, allosterically coupled to each other, control BK channel activity and are potential targets for regulation by auxiliary β-subunits that are expressed together with the α (BK)-subunit in almost every tissue type where they are found. By measuring gating currents in BK channels coexpressed with chimeras between β1 and β3 or β2 auxiliary subunits, we were able to identify that the cytoplasmic regions of β1 are responsible for the modulation of the voltage sensors. In addition, we narrowed down the structural determinants to the N terminus of β1, which contains two lysine residues (i.e., K3 and K4), which upon substitution virtually abolished the effects of β1 on charge movement. The mechanism by which K3 and K4 stabilize the voltage sensor is not electrostatic but specific, and the α (BK)-residues involved remain to be identified. This is the first report, to our knowledge, where the regulatory effects of the β1-subunit have been clearly assigned to a particular segment, with two pivotal amino acids being responsible for this modulation.

  11. Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein.

    Lee, Hye Young; Ge, Woo-Ping; Huang, Wendy; He, Ye; Wang, Gordon X; Rowson-Baldwin, Ashley; Smith, Stephen J; Jan, Yuh Nung; Jan, Lily Yeh


    How transmitter receptors modulate neuronal signaling by regulating voltage-gated ion channel expression remains an open question. Here we report dendritic localization of mRNA of Kv4.2 voltage-gated potassium channel, which regulates synaptic plasticity, and its local translational regulation by fragile X mental retardation protein (FMRP) linked to fragile X syndrome (FXS), the most common heritable mental retardation. FMRP suppression of Kv4.2 is revealed by elevation of Kv4.2 in neurons from fmr1 knockout (KO) mice and in neurons expressing Kv4.2-3'UTR that binds FMRP. Moreover, treating hippocampal slices from fmr1 KO mice with Kv4 channel blocker restores long-term potentiation induced by moderate stimuli. Surprisingly, recovery of Kv4.2 after N-methyl-D-aspartate receptor (NMDAR)-induced degradation also requires FMRP, likely due to NMDAR-induced FMRP dephosphorylation, which turns off FMRP suppression of Kv4.2. Our study of FMRP regulation of Kv4.2 deepens our knowledge of NMDAR signaling and reveals a FMRP target of potential relevance to FXS.

  12. Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

    Zhou, Meng-Hua; Bavencoffe, Alexis; Pan, Hui-Lin


    Nitric oxide (NO) is involved in a variety of physiological processes, such as vasoregulation and neurotransmission, and has a complex role in the regulation of pain transduction and synaptic transmission. We have shown previously that NO inhibits high voltage-activated Ca(2+) channels in primary sensory neurons and excitatory synaptic transmission in the spinal dorsal horn. However, the molecular mechanism involved in this inhibitory action remains unclear. In this study, we investigated the role of S-nitrosylation in the NO regulation of high voltage-activated Ca(2+) channels. The NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) rapidly reduced N-type currents when Cav2.2 was coexpressed with the Cavβ1 or Cavβ3 subunits in HEK293 cells. In contrast, SNAP only slightly inhibited P/Q-type and L-type currents reconstituted with various Cavβ subunits. SNAP caused a depolarizing shift in voltage-dependent N-type channel activation, but it had no effect on Cav2.2 protein levels on the membrane surface. The inhibitory effect of SNAP on N-type currents was blocked by the sulfhydryl-specific modifying reagent methanethiosulfonate ethylammonium. Furthermore, the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 than in Cav1.2 and Cav2.1. Site-directed mutagenesis studies showed that Cys-805, Cys-930, and Cys-1045 in the II-III intracellular loop, Cys-1835 and Cys-2145 in the C terminus of Cav2.2, and Cys-346 in the Cavβ3 subunit were nitrosylation sites mediating NO sensitivity of N-type channels. Our findings demonstrate that the consensus motifs of S-nitrosylation in cytoplasmically accessible sites are critically involved in post-translational regulation of N-type Ca(2+) channels by NO. S-Nitrosylation mediates the feedback regulation of N-type channels by NO.

  13. PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

    Mark Alan Zaydman


    Full Text Available Voltage-gated potassium (Kv channels contain voltage-sensing (VSD and pore-gate (PGD structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In addition to membrane voltage, KCNQ (Kv7 channel opening requires the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2. Recent studies suggest that PIP2 serves as a cofactor to mediate VSD-PGD coupling in KCNQ1 channels. In this review, we put these findings in the context of the current understanding of voltage-dependent gating, lipid modulation of Kv channel activation, and PIP2-regulation of KCNQ channels. We suggest that lipid-mediated coupling of functional domains is a common mechanism among KCNQ channels that may be applicable to other Kv channels and membrane proteins.

  14. PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating.

    Zaydman, Mark A; Cui, Jianmin


    Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In addition to membrane voltage, KCNQ (Kv7) channel opening requires the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). Recent studies suggest that PIP2 serves as a cofactor to mediate VSD-PGD coupling in KCNQ1 channels. In this review, we put these findings in the context of the current understanding of voltage-dependent gating, lipid modulation of Kv channel activation, and PIP2-regulation of KCNQ channels. We suggest that lipid-mediated coupling of functional domains is a common mechanism among KCNQ channels that may be applicable to other Kv channels and membrane proteins.

  15. Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density.

    Perissinotti, Paula P; Ethington, Elizabeth G; Cribbs, Leanne; Koob, Michael D; Martin, Jody; Piedras-Rentería, Erika S


    The actin-binding protein Kelch-like 1 (KLHL1) can modulate voltage-gated calcium channels in vitro. KLHL1 interacts with actin and with the pore-forming subunits of Cav2.1 and CaV3.2 calcium channels, resulting in up-regulation of P/Q and T-type current density. Here we tested whether endogenous KLHL1 modulates voltage gated calcium currents in cultured hippocampal neurons by down-regulating the expression of KLHL1 via adenoviral delivery of shRNA targeted against KLHL1 (shKLHL1). Control adenoviruses did not affect any of the neuronal properties measured, yet down-regulation of KLHL1 resulted in HVA current densities ~68% smaller and LVA current densities 44% smaller than uninfected controls, with a concomitant reduction in α(1A) and α(1H) protein levels. Biophysical analysis and western blot experiments suggest Ca(V)3.1 and 3.3 currents are also present in shKLHL1-infected neurons. Synapsin I levels, miniature postsynaptic current frequency, and excitatory and inhibitory synapse number were reduced in KLHL1 knockdown. This study corroborates the physiological role of KLHL1 as a calcium channel modulator and demonstrates a novel, presynaptic role.

  16. Design of the robust synchronous generator stator voltage regulator based on the interval plant model

    Stojić Đorđe


    Full Text Available In this paper a novel method for the stator voltage regulator of a synchronous generator based on the interval plant mode, is presented. Namely, it is shown in the literature that, in order to design a controller for the first-order compensator, the limited number of interval plants needs to be examined. Consequently, the intervals of the plant model parameter variations used to calculate the four extreme interval plants required for the sequential PI controller design are determined. The controller is designed using frequency-domain-based techniques, while its robust performance is examined using simulation tests.

  17. Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation.

    Fraser, Scott P; Ozerlat-Gunduz, Iley; Brackenbury, William J; Fitzgerald, Elizabeth M; Campbell, Thomas M; Coombes, R Charles; Djamgoz, Mustafa B A


    Although ion channels are increasingly being discovered in cancer cells in vitro and in vivo, and shown to contribute to different aspects and stages of the cancer process, much less is known about the mechanisms controlling their expression. Here, we focus on voltage-gated Na(+) channels (VGSCs) which are upregulated in many types of carcinomas where their activity potentiates cell behaviours integral to the metastatic cascade. Regulation of VGSCs occurs at a hierarchy of levels from transcription to post-translation. Importantly, mainstream cancer mechanisms, especially hormones and growth factors, play a significant role in the regulation. On the whole, in major hormone-sensitive cancers, such as breast and prostate cancer, there is a negative association between genomic steroid hormone sensitivity and functional VGSC expression. Activity-dependent regulation by positive feedback has been demonstrated in strongly metastatic cells whereby the VGSC is self-sustaining, with its activity promoting further functional channel expression. Such auto-regulation is unlike normal cells in which activity-dependent regulation occurs mostly via negative feedback. Throughout, we highlight the possible clinical implications of functional VGSC expression and regulation in cancer.

  18. Functional reconstitution of the voltage-regulated sodium channel purified from electroplax of Electrophorus electricus

    Rosenberg, R.L.


    The voltage-regulated NA channel is responsible for the depolarization of the excitable cell membrane during the normal action potential. This research has focused on the functional properties of the Na channel, purified from detergent extracts of electroplax membranes of the electric eel, and reconstituted into vesicles of defined phospholipid. These properties were assessed by measuring neurotoxin-modulated ion flux into the reconstituted membrane vesicles and by recording the single-channel currents of the purified channel by the patch-clamp method. The binding of tritiated tetrodotoxin (TTX) was employed as a marker for the purification of the channel. Two high-resolution fractionation steps, based on molecular charge and protein size, were used to obtain a preparation that is 80% homogeneous for a large peptide of 270,000 daltons. Radiotracer /sup 22/Na/sup +/ influx into the vesicles was stimulated by veratridine and by batrachotoxin (BTX) at concentrations of 100 and 5, respectively. The stimulation by BTX was greater than that by veratridine, and can be as much as 16-fold over control influx levels. The stimulated influx is blocked by TTX with a K/sub i/ of 35 nM, and by local anesthetics in the normal pharmacological range. Large multilamellar vesicles prepared with a freeze-thaw step are suitable for single-channel recording techniques. When excised patches of the reconstituted membranes were voltage-clamped in the absence of activating neurotoxins, voltage-dependent single-channel currents were recorded. These displayed properties similar to those from native membranes of nerve and muscle. These results indicate that the protein purified on the basis of TTX binding is a functional Na channel possessing these functional domains: the ion-selective channel, the voltage sensors controlling activation and inactivation, and the sites of action of TTX, alkaloid neurotoxins, and local anesthetics.

  19. Fuzzy Controller for a Voltage-Regulated Solar-Powered MPPT System for Hybrid Power System Applications

    Jaw-Kuen Shiau


    Full Text Available This paper presents the design of a fuzzy-logic-based voltage-regulated solar power maximum power point tracking (MPPT system for applications involving hybrid power systems. The system contains a solar power system and battery as the primary and secondary power sources, respectively. The solar system alone supplies power to the electric motor and maintains the output voltage at a predetermined level when it has sufficient power. When the solar power is insufficient, the solar system is operated at its maximum power point (MPP and the battery is engaged to compensate for the insufficiency. First, a variant of the incremental conductance MPP condition was established. Under the MPP condition, the voltage-regulated MPPT system was formulated as a feedback control system, where the MPP condition and voltage regulation requirements were used as the system inputs. Next, a fuzzy controller was developed to perform the voltage-regulated MPPT function for the hybrid power system. A simulation model based on Matrix laboratory (MATLAB/SIMULINK (a block diagram environment for multi-domain simulation and model-based design and a piecewise linear electric circuit simulation (PLECS tool for controlling the dc motor velocity was developed to verify the voltage-regulated solar power MPPT system.

  20. Micromolar-Affinity Benzodiazepine Receptors Regulate Voltage-Sensitive Calcium Channels in Nerve Terminal Preparations

    Taft, William C.; Delorenzo, Robert J.


    Benzodiazepines in micromolar concentrations significantly inhibit depolarization-sensitive Ca2+ uptake in intact nerve-terminal preparations. Benzodiazepine inhibition of Ca2+ uptake is concentration dependent and stereospecific. Micromolar-affinity benzodiazepine receptors have been identified and characterized in brain membrane and shown to be distinct from nanomolar-affinity benzodiazepine receptors. Evidence is presented that micromolar, and not nanomolar, benzodiazepine binding sites mediate benzodiazepine inhibition of Ca2+ uptake. Irreversible binding to micromolar benzodiazepine binding sites also irreversibly blocked depolarization-dependent Ca2+ uptake in synaptosomes, indicating that these compounds may represent a useful marker for identifying the molecular components of Ca2+ channels in brain. Characterization of benzodiazepine inhibition of Ca2+ uptake demonstrates that these drugs function as Ca2+ channel antagonists, because benzodiazepines effectively blocked voltage-sensitive Ca2+ uptake inhibited by Mn2+, Co2+, verapamil, nitrendipine, and nimodipine. These results indicate that micromolar benzodiazepine binding sites regulate voltage-sensitive Ca2+ channels in brain membrane and suggest that some of the neuronal stabilizing effects of micromolar benzodiazepine receptors may be mediated by the regulation of Ca2+ conductance.

  1. A Capacitor-Free, Fast Transient Response Linear Voltage Regulator In a 180nm CMOS

    Deleuran, Alexander N.; Lindbjerg, Nicklas; Pedersen, Martin K.


    A 1.8 V capacitor-free linear regulator with fast transient response based on a new topology with a fast and slow regulation loop is presented. The design has been laid out and simulated in a 0.18 µm CMOS process. The design has a low component count and is tailored for system-on-chip integration....... A current step load from 0-50 mA with a rise time of 1 µs results in an undershoot in the output voltage of 140 mV for a period of 39 ns. The regulator sources up to 50 mA current load.......A 1.8 V capacitor-free linear regulator with fast transient response based on a new topology with a fast and slow regulation loop is presented. The design has been laid out and simulated in a 0.18 µm CMOS process. The design has a low component count and is tailored for system-on-chip integration...

  2. Three Phase Two Leg Neutral Point Clamped Converter with output DC Voltage Regulation and Input Power Factor Correction

    Bogimi Sirisha


    Full Text Available In this paper, a three-phase two leg neutral point clamped (NPC converter is presented for power factor correction and dc-link voltage regulation. The adopted converter has simpler circuit configuration and less number of power switches compared to three-level PWM converter. In this circuit configuration, only eight power switches and four clamping diodes with voltage stress of half the dc bus voltage are used. A simplified space vector pulse width modulation scheme (SVPWM is also adopted to track the line current commands. A reference voltage vector is generated on the ac terminal for drawing the sinusoidal line currents with unity power factor. This algorithm reduces the time required to calculate the switching time durations of voltage vectors. The simulation results have been presented to verify the validity and effectiveness of the proposed control strategy.

  3. Regulation of membrane excitability: a convergence on voltage-gated sodium conductance.

    Lin, Wei-Hsiang; Baines, Richard A


    The voltage-gated sodium channel (Nav) plays a key role in regulation of neuronal excitability. Aberrant regulation of Nav expression and/or function can result in an imbalance in neuronal activity which can progress to epilepsy. Regulation of Nav activity is achieved by coordination of a multitude of mechanisms including RNA alternative splicing and translational repression. Understanding of these regulatory mechanisms is complicated by extensive genetic redundancy: the mammalian genome encodes ten Navs. By contrast, the genome of the fruitfly, Drosophila melanogaster, contains just one Nav homologue, encoded by paralytic (DmNa v ). Analysis of splicing in DmNa v shows variants exhibit distinct gating properties including varying magnitudes of persistent sodium current (INaP). Splicing by Pasilla, an identified RNA splicing factor, alters INaP magnitude as part of an activity-dependent mechanism. Enhanced INaP promotes membrane hyperexcitability that is associated with seizure-like behaviour in Drosophila. Nova-2, a mammalian Pasilla homologue, has also been linked to splicing of Navs and, moreover, mouse gene knockouts display seizure-like behaviour.Expression level of Navs is also regulated through a mechanism of translational repression in both flies and mammals. The translational repressor Pumilio (Pum) can bind to Na v transcripts and repress the normal process of translation, thus regulating sodium current (INa) density in neurons. Pum2-deficient mice exhibit spontaneous EEG abnormalities. Taken together, aberrant regulation of Nav function and/or expression is often epileptogenic. As such, a better understanding of regulation of membrane excitability through RNA alternative splicing and translational repression of Navs should provide new leads to treat epilepsy.

  4. Reciprocal regulation of reactive oxygen species and phospho-CREB regulates voltage gated calcium channel expression during Mycobacterium tuberculosis infection.

    Arti Selvakumar

    Full Text Available Our previous work has demonstrated the roles played by L-type Voltage Gated Calcium Channels (VGCC in regulating Mycobacterium tuberculosis (M. tb survival and pathogenesis. Here we decipher mechanisms and pathways engaged by the pathogen to regulate VGCC expression in macrophages. We show that M. tb and its antigen Rv3416 use phospho-CREB (pCREB, Reactive Oxygen Species (ROS, Protein Kinase C (PKC and Mitogen Activated Protein Kinase (MAPK to modulate VGCC expression in macrophages. siRNA mediated knockdown of MyD88, IRAK1, IRAK2 or TRAF6 significantly inhibited antigen mediated VGCC expression. Inhibiting Protein Kinase C (PKC or MEK-ERK1/2 further increased VGCC expression. Interestingly, inhibiting intracellular calcium release upregulated antigen mediated VGCC expression, while inhibiting extracellular calcium influx had no significant effect. siRNA mediated knockdown of transcription factors c-Jun, SOX5 and CREB significantly inhibited Rv3416 mediated VGCC expression. A dynamic reciprocal cross-regulation between ROS and pCREB was observed that in turn governed VGCC expression with ROS playing a limiting role in the process. Further dissection of the mechanisms such as the interplay between ROS and pCREB would improve our understanding of the regulation of VGCC expression during M. tb infection.

  5. Programmable Voltage Regulating Method for 15 kV High Voltage DC Power Supply%15 kV高压直流电源的程控调压方法

    肖剑锋; 陈新; 米彦


    In order to solve the disadvantages caused by mechanical slide rheostat that has big errors and low precision, a novel voltage regulation method for high voltage DC power supply was introduced. The key of this method were digital potentiometer MAXIM 5455 and linear photoelectric coupling LOC110, and application programs were compiled using Visual Basic which was graphical compiling language, furthermore the communication between exterior and computer was carried out by ICP7044D module, in consequence the output value of high voltage DC power supply could be regulated with computer. The measured results showed that this method could accurately, conveniently and rapidly regulate the output value of high voltage DC power supply.

  6. Application of thyristor in voltage regulation%晶闸管在调压技术中的应用

    刘晓青; 刘伟


    阐述了晶闸管的工作特性,主要从晶闸管整流电路和晶闸管交流调压电路两方面,分析了如何利用晶闸管的特性进行调压.%The paper described the work characteristics of the thyristor, and analyzed how to adjust the voltage using the characteristics of the thyristor, mainly including rectifier circuit and Ac voltage regulation circuit with thyristors. Analysis showed that voltage controllers with thyristors are widely used in various industries because of its simpleness and practicality.

  7. A Decentralized Multivariable Robust Adaptive Voltage and Speed Regulator for Large-Scale Power Systems

    Okou, Francis A.; Akhrif, Ouassima; Dessaint, Louis A.; Bouchard, Derrick


    This papter introduces a decentralized multivariable robust adaptive voltage and frequency regulator to ensure the stability of large-scale interconnnected generators. Interconnection parameters (i.e. load, line and transormer parameters) are assumed to be unknown. The proposed design approach requires the reformulation of conventiaonal power system models into a multivariable model with generator terminal voltages as state variables, and excitation and turbine valve inputs as control signals. This model, while suitable for the application of modern control methods, introduces problems with regards to current design techniques for large-scale systems. Interconnection terms, which are treated as perturbations, do not meet the common matching condition assumption. A new adaptive method for a certain class of large-scale systems is therefore introduces that does not require the matching condition. The proposed controller consists of nonlinear inputs that cancel some nonlinearities of the model. Auxiliary controls with linear and nonlinear components are used to stabilize the system. They compensate unknown parametes of the model by updating both the nonlinear component gains and excitation parameters. The adaptation algorithms involve the sigma-modification approach for auxiliary control gains, and the projection approach for excitation parameters to prevent estimation drift. The computation of the matrix-gain of the controller linear component requires the resolution of an algebraic Riccati equation and helps to solve the perturbation-mismatching problem. A realistic power system is used to assess the proposed controller performance. The results show that both stability and transient performance are considerably improved following a severe contingency.

  8. Damping improvement and terminal voltage regulation for a synchronous machine using an energy storage device

    Kim, Seok-Kyoon; Song, Hwachang; Yoon, Tae-Woong


    On the basis of the non-linear third-order generator model, this article proposes a dual control scheme for a single synchronous machine equipped with an energy storage device to regulate the terminal voltage while enhancing the damping. Based on the input-output feedback linearisation method, the exciter controller is designed such that the terminal voltage robustly converges to its predetermined reference in the presence of a model uncertainty. In addition, the control input of the energy storage device feedbacks only the relative speed. It is shown that this controller can effectively increase the damping of the synchronous machine and that there is a set of initial conditions such that all trajectories started from this set go to the equilibrium point, satisfying input constraints. Moreover, it is also verified that all generator variables are bounded except for the power angle. The simulation results show that the closed-loop performance is satisfactory despite a transmission line fault and a model uncertainty in which the non-linear fourth-order generator model (two-axis) is used.

  9. Tuning of PID controller for an automatic regulator voltage system using chaotic optimization approach

    Santos Coelho, Leandro dos [Pontifical Catholic University of Parana, PUCPR Industrial and Systems Engineering Graduate Program, LAS/PPGEPS Imaculada Conceicao, 1155, Zip code 80215-901, Curitiba, Parana (Brazil)], E-mail:


    Despite the popularity, the tuning aspect of proportional-integral-derivative (PID) controllers is a challenge for researchers and plant operators. Various controllers tuning methodologies have been proposed in the literature such as auto-tuning, self-tuning, pattern recognition, artificial intelligence, and optimization methods. Chaotic optimization algorithms as an emergent method of global optimization have attracted much attention in engineering applications. Chaotic optimization algorithms, which have the features of easy implementation, short execution time and robust mechanisms of escaping from local optimum, is a promising tool for engineering applications. In this paper, a tuning method for determining the parameters of PID control for an automatic regulator voltage (AVR) system using a chaotic optimization approach based on Lozi map is proposed. Since chaotic mapping enjoys certainty, ergodicity and the stochastic property, the proposed chaotic optimization introduces chaos mapping using Lozi map chaotic sequences which increases its convergence rate and resulting precision. Simulation results are promising and show the effectiveness of the proposed approach. Numerical simulations based on proposed PID control of an AVR system for nominal system parameters and step reference voltage input demonstrate the good performance of chaotic optimization.

  10. The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.

    Ting-Feng Lin

    Full Text Available Eag (Kv10 and Erg (Kv11 belong to two distinct subfamilies of the ether-à-go-go K+ channel family (KCNH. While Erg channels are characterized by an inward-rectifying current-voltage relationship that results from a C-type inactivation, mammalian Eag channels display little or no voltage-dependent inactivation. Although the amino (N-terminal region such as the eag domain is not required for the C-type inactivation of Erg channels, an N-terminal deletion in mouse Eag1 has been shown to produce a voltage-dependent inactivation. To further discern the role of the eag domain in the inactivation of Eag1 channels, we generated N-terminal chimeras between rat Eag (rEag1 and human Erg (hERG1 channels that involved swapping the eag domain alone or the complete cytoplasmic N-terminal region. Functional analyses indicated that introduction of the homologous hERG1 eag domain led to both a fast phase and a slow phase of channel inactivation in the rEag1 chimeras. By contrast, the inactivation features were retained in the reverse hERG1 chimeras. Furthermore, an eag domain-lacking rEag1 deletion mutant also showed the fast phase of inactivation that was notably attenuated upon co-expression with the rEag1 eag domain fragment, but not with the hERG1 eag domain fragment. Additionally, we have identified a point mutation in the S4-S5 linker region of rEag1 that resulted in a similar inactivation phenotype. Biophysical analyses of these mutant constructs suggested that the inactivation gating of rEag1 was distinctly different from that of hERG1. Overall, our findings are consistent with the notion that the eag domain plays a critical role in regulating the inactivation gating of rEag1. We propose that the eag domain may destabilize or mask an inherent voltage-dependent inactivation of rEag1 K+ channels.

  11. Power Generation and Voltage Regulation of 132KV Karbala grid using DFIG Wind Turbine Generator

    Qasim Kamil Mohsin


    Full Text Available Due to increasing demand on electrical energy in Iraq and to have clean energy that is environmental friendly, wind energy would be one of the most important and promising sources of renewable energy to achieve this goal. This paper discussed the reasons to use the Doubly-Feed Induction Generator (DFIG amongst the available types of wind turbine generators, and in section (III illustrate Motivations to select place to the wind farm construction. using decupling method (the vector control strategy to change reactive power of DFIG 2MW connected to middle of the 132KV transmission line (Karbala north – Alahkader without effect about the active power generated from DFIG itself with fixed wind speed value assumed to provide the voltage regulation, and control of the transmission line In addition to power generating. By using PSCAD/EMTDC, different simulation results are presented based on various scenarios.

  12. Regulation of KCNQ/Kv7 family voltage-gated K(+) channels by lipids.

    Taylor, Keenan C; Sanders, Charles R


    Many years of studies have established that lipids can impact membrane protein structure and function through bulk membrane effects, by direct but transient annular interactions with the bilayer-exposed surface of protein transmembrane domains, and by specific binding to protein sites. Here, we focus on how phosphatidylinositol 4,5-bisphosphate (PIP2) and polyunsaturated fatty acids (PUFAs) impact ion channel function and how the structural details of the interactions of these lipids with ion channels are beginning to emerge. We focus on the Kv7 (KCNQ) subfamily of voltage-gated K(+) channels, which are regulated by both PIP2 and PUFAs and play a variety of important roles in human health and disease. This article is part of a Special Issue entitled: Lipid order/lipid defects and lipid-control of protein activity edited by Dirk Schneider.

  13. Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels.

    Ben-Johny, Manu; Dick, Ivy E; Sang, Lingjie; Limpitikul, Worawan B; Kang, Po Wei; Niu, Jacqueline; Banerjee, Rahul; Yang, Wanjun; Babich, Jennifer S; Issa, John B; Lee, Shin Rong; Namkung, Ho; Li, Jiangyu; Zhang, Manning; Yang, Philemon S; Bazzazi, Hojjat; Adams, Paul J; Joshi-Mukherjee, Rosy; Yue, Daniel N; Yue, David T


    Voltage-gated Na and Ca(2+) channels represent two major ion channel families that enable myriad biological functions including the generation of action potentials and the coupling of electrical and chemical signaling in cells. Calmodulin regulation (calmodulation) of these ion channels comprises a vital feedback mechanism with distinct physiological implications. Though long-sought, a shared understanding of the channel families remained elusive for two decades as the functional manifestations and the structural underpinnings of this modulation often appeared to diverge. Here, we review recent advancements in the understanding of calmodulation of Ca(2+) and Na channels that suggest a remarkable similarity in their regulatory scheme. This interrelation between the two channel families now paves the way towards a unified mechanistic framework to understand vital calmodulin-dependent feedback and offers shared principles to approach related channelopathic diseases. An exciting era of synergistic study now looms.

  14. Voltage gated calcium channels negatively regulate protective immunity to Mycobacterium tuberculosis.

    Shashank Gupta

    Full Text Available Mycobacterium tuberculosis modulates levels and activity of key intracellular second messengers to evade protective immune responses. Calcium release from voltage gated calcium channels (VGCC regulates immune responses to pathogens. In this study, we investigated the roles of VGCC in regulating protective immunity to mycobacteria in vitro and in vivo. Inhibiting L-type or R-type VGCC in dendritic cells (DCs either using antibodies or by siRNA increased calcium influx in an inositol 1,4,5-phosphate and calcium release calcium activated channel dependent mechanism that resulted in increased expression of genes favoring pro-inflammatory responses. Further, VGCC-blocked DCs activated T cells that in turn mediated killing of M. tuberculosis inside macrophages. Likewise, inhibiting VGCC in infected macrophages and PBMCs induced calcium influx, upregulated the expression of pro-inflammatory genes and resulted in enhanced killing of intracellular M. tuberculosis. Importantly, compared to healthy controls, PBMCs of tuberculosis patients expressed higher levels of both VGCC, which were significantly reduced following chemotherapy. Finally, blocking VGCC in vivo in M. tuberculosis infected mice using specific antibodies increased intracellular calcium and significantly reduced bacterial loads. These results indicate that L-type and R-type VGCC play a negative role in M. tuberculosis infection by regulating calcium mobilization in cells that determine protective immunity.

  15. Preparation of Power Distribution System for High Penetration of Renewable Energy Part I. Dynamic Voltage Restorer for Voltage Regulation Pat II. Distribution Circuit Modeling and Validation

    Khoshkbar Sadigh, Arash

    other analyses. In this study, ETAP, OpenDSS, and GridLab-D are considered, and PSCMD transfer applications written in MATLAB have been developed for each of these to read the circuit model data provided in the UP spreadsheet. In order to test the developed PSCMD transfer applications, circuit model data of a test circuit and a power distribution circuit from Southern California Edison (SCE) - a utility company - both built in CYME, were exported into the spreadsheet file according to the UP format. Thereafter, circuit model data were imported successfully from the spreadsheet files into above mentioned software using the PSCMD transfer applications developed for each software. After the SCE studied circuit is transferred into OpenDSS software using the proposed UP scheme and developed application, it has been studied to investigate the impacts of large-scale solar energy penetration. The main challenge of solar energy integration into power grid is its intermittency (i.e., discontinuity of output power) nature due to cloud shading of photovoltaic panels which depends on weather conditions. In order to conduct this study, OpenDSS time-series simulation feature, which is required due to intermittency of solar energy, is utilized. In this study, the impacts of intermittency of solar energy penetration, especially high-variability points, on voltage fluctuation and operation of capacitor bank and voltage regulator is provided. In addition, the necessity to interpolate and resample unequally spaced time-series measurement data and convert them to equally spaced time-series data as well as the effect of resampling time-interval on the amount of error is discussed. Two applications are developed in Matlab to do interpolation and resampling as well as to calculate the amount of error for different resampling time-intervals to figure out the suitable resampling time-interval. Furthermore, an approach based on cumulative distribution, regarding the length for lines/cables types

  16. Regulation of voltage-gated potassium channels by PI(4,5)P2.

    Kruse, Martin; Hammond, Gerald R V; Hille, Bertil


    Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) regulates activities of numerous ion channels including inwardly rectifying potassium (K(ir)) channels, KCNQ, TRP, and voltage-gated calcium channels. Several studies suggest that voltage-gated potassium (K(V)) channels might be regulated by PI(4,5)P(2). Wide expression of K(V) channels in different cells suggests that such regulation could have broad physiological consequences. To study regulation of K(V) channels by PI(4,5)P(2), we have coexpressed several of them in tsA-201 cells with a G protein-coupled receptor (M(1)R), a voltage-sensitive lipid 5-phosphatase (Dr-VSP), or an engineered fusion protein carrying both lipid 4-phosphatase and 5-phosphatase activity (pseudojanin). These tools deplete PI(4,5)P(2) with application of muscarinic agonists, depolarization, or rapamycin, respectively. PI(4,5)P(2) at the plasma membrane was monitored by Förster resonance energy transfer (FRET) from PH probes of PLCδ1 simultaneously with whole-cell recordings. Activation of Dr-VSP or recruitment of pseudojanin inhibited K(V)7.1, K(V)7.2/7.3, and K(ir)2.1 channel current by 90-95%. Activation of M(1)R inhibited K(V)7.2/7.3 current similarly. With these tools, we tested for potential PI(4,5)P(2) regulation of activity of K(V)1.1/K(V)β1.1, K(V)1.3, K(V)1.4, and K(V)1.5/K(V)β1.3, K(V)2.1, K(V)3.4, K(V)4.2, K(V)4.3 (with different KChIPs and DPP6-s), and hERG/KCNE2. Interestingly, we found a substantial removal of inactivation for K(V)1.1/K(V)β1.1 and K(V)3.4, resulting in up-regulation of current density upon activation of M(1)R but no changes in activity upon activating only VSP or pseudojanin. The other channels tested except possibly hERG showed no alteration in activity in any of the assays we used. In conclusion, a depletion of PI(4,5)P(2) at the plasma membrane by enzymes does not seem to influence activity of most tested K(V) channels, whereas it does strongly inhibit members of the K(V)7 and K(ir) families.

  17. Regulation of voltage-gated sodium current by endogenous Src family kinases in cochlear spiral ganglion neurons in culture.

    Feng, Shuang; Pflueger, Melissa; Lin, Shuang-Xiu; Groveman, Bradley R; Su, Jiping; Yu, Xian-Min


    Voltage-gated sodium (Na+) and potassium (K+)channels have been found to be regulated by Src family kinases(SFKs).However, how these channels are regulated by SFKs in cochlear spiral ganglion neurons (SGNs) remains unknown.Here, we report that altering the activity of endogenous SFKs modulated voltage-gated Na+, but not K+, currents recorded in embryonic SGNs in culture. Voltage-gated Na+ current was suppressed by inhibition of endogenous SFKs or just Src and potentiated by the activation of these enzymes. Detailed investigations showed that under basal conditions, SFK inhibitor application did not significantly affect the voltage-dependent activation, but shifted the steady-state inactivation curves of Na+ currents and delayed the recovery of Na+ currents from inactivation. Application of Src specific inhibitor, Src40–58,not only shifted the inactivation curve but also delayed the recovery of Na+ currents and moved the voltage-dependent activation curve towards the left. The pre-inhibition of SFKs occluded all the effects induced by Src40–58 application, except the left shift of the activation curve. The activation of SFKs did not change either steady-state inactivation or recovery of Na+ currents, but caused the left shift of the activation curve.SFK inhibitor application effectively prevented all the effects induced by SFK activation, suggesting that both the voltage-dependent activation and steady-state inactivation of Na+ current are subjects of SFK regulation. The different effects induced by activation versus inhibition of SFKs implied that under basal conditions, endogenously active and inactive SFKs might be differentially involved in the regulation of voltage-gated Na+ channels in SGNs.

  18. Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.

    Pitt, Geoffrey S; Lee, Seok-Yong


    In cardiac and skeletal myocytes, and in most neurons, the opening of voltage-gated Na(+) channels (NaV channels) triggers action potentials, a process that is regulated via the interactions of the channels' intercellular C-termini with auxiliary proteins and/or Ca(2+) . The molecular and structural details for how Ca(2+) and/or auxiliary proteins modulate NaV channel function, however, have eluded a concise mechanistic explanation and details have been shrouded for the last decade behind controversy about whether Ca(2+) acts directly upon the NaV channel or through interacting proteins, such as the Ca(2+) binding protein calmodulin (CaM). Here, we review recent advances in defining the structure of NaV intracellular C-termini and associated proteins such as CaM or fibroblast growth factor homologous factors (FHFs) to reveal new insights into how Ca(2+) affects NaV function, and how altered Ca(2+) -dependent or FHF-mediated regulation of NaV channels is perturbed in various disease states through mutations that disrupt CaM or FHF interaction.

  19. Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect.

    Lemasters, John J; Holmuhamedov, Ekhson L; Czerny, Christoph; Zhong, Zhi; Maldonado, Eduardo N


    Voltage dependent anion channels (VDAC) are highly conserved proteins that are responsible for permeability of the mitochondrial outer membrane to hydrophilic metabolites like ATP, ADP and respiratory substrates. Although previously assumed to remain open, VDAC closure is emerging as an important mechanism for regulation of global mitochondrial metabolism in apoptotic cells and also in cells that are not dying. During hepatic ethanol oxidation to acetaldehyde, VDAC closure suppresses exchange of mitochondrial metabolites, resulting in inhibition of ureagenesis. In vivo, VDAC closure after ethanol occurs coordinately with mitochondrial uncoupling. Since acetaldehyde passes through membranes independently of channels and transporters, VDAC closure and uncoupling together foster selective and more rapid oxidative metabolism of toxic acetaldehyde to nontoxic acetate by mitochondrial aldehyde dehydrogenase. In single reconstituted VDAC, tubulin decreases VDAC conductance, and in HepG2 hepatoma cells, free tubulin negatively modulates mitochondrial membrane potential, an effect enhanced by protein kinase A. Tubulin-dependent closure of VDAC in cancer cells contributes to suppression of mitochondrial metabolism and may underlie the Warburg phenomenon of aerobic glycolysis. This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism.

  20. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation.

    Abbott, Geoffrey W


    The human KCNE gene family comprises five genes encoding single transmembrane-spanning ion channel regulatory subunits. The primary function of KCNE subunits appears to be regulation of voltage-gated potassium (Kv) channels, and the best-understood KCNE complexes are with the KCNQ1 Kv α subunit. Here, we review the often opposite effects of KCNE1 and KCNE3 on Kv channel biology, with an emphasis on regulation of KCNQ1. Slow-activating IKs channel complexes formed by KCNQ1 and KCNE1 are essential for human ventricular myocyte repolarization, while constitutively active KCNQ1-KCNE3 channels are important in the intestine. Inherited sequence variants in human KCNE1 and KCNE3 cause cardiac arrhythmias but by different mechanisms, and each is important for hearing in unique ways. Because of their contrasting effects on KCNQ1 function, KCNE1 and KCNE3 have proved invaluable tools in the mechanistic understanding of how channel gating can be manipulated, and each may also provide a window into novel insights and new therapeutic opportunities in K(+) channel pharmacology. Finally, findings from studies of Kcne1(-/-) and Kcne3(-/-) mouse lines serve to illustrate the complexity of KCNE biology and KCNE-linked disease states.

  1. A Low Input Current and Wide Conversion Ratio Buck Regulator with 75% Efficiency for High-Voltage Triboelectric Nanogenerators

    Luo, Li-Chuan; Bao, De-Chun; Yu, Wu-Qi; Zhang, Zhao-Hua; Ren, Tian-Ling


    It is meaningful to research the Triboelectric Nanogenerators (TENG), which can create electricity anywhere and anytime. There are many researches on the structures and materials of TENG to explain the phenomenon that the maximum voltage is stable and the current is increasing. The output voltage of the TENG is high about 180-400 V, and the output current is small about 39 μA, which the electronic devices directly integration of TENG with Li-ion batteries will result in huge energy loss due to the ultrahigh TENG impedance. A novel interface circuit with the high-voltage buck regulator for TENG is introduced firstly in this paper. The interface circuit can transfer the output signal of the TENG into the signal fit to a lithium ion battery. Through the circuit of the buck regulator, the average output voltage is about 4.0 V and the average output current is about 1.12 mA. Further, the reliability and availability for the lithium ion battery and the circuit are discussed. The interface circuit is simulated using the Cadence software and verified through PCB experiment. The buck regulator can achieve 75% efficiency for the High-Voltage TENG. This will lead to a research hot and industrialization applications.

  2. Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals.

    Brooke, Ruth E; Moores, Thomas S; Morris, Neil P; Parson, Simon H; Deuchars, Jim


    Voltage-gated potassium (Kv) channels are critical to regulation of neurotransmitter release throughout the nervous system but the roles and identity of the subtypes involved remain unclear. Here we show that Kv3 channels regulate transmitter release at the mouse neuromuscular junction (NMJ). Light- and electron-microscopic immunohistochemistry revealed Kv3.3 and Kv3.4 subunits within all motor nerve terminals of muscles examined [transversus abdominus, lumbrical and flexor digitorum brevis (FDB)]. To determine the roles of these Kv3 subunits, intracellular recordings were made of end-plate potentials (EPPs) in FDB muscle fibres evoked by electrical stimulation of tibial nerve. Tetraethylammonium (TEA) applied at low concentrations (0.05-0.5 mM), which blocks only a few known potassium channels including Kv3 channels, did not affect muscle fibre resting potential but significantly increased the amplitude of all EPPs tested. Significantly, this effect of TEA was still observed in the presence of the large-conductance calcium-activated potassium channel blockers iberiotoxin (25-150 nM) and Penitrem A (100 nM), suggesting a selective action on Kv3 subunits. Consistent with this, 15-microM 4-aminopyridine, which blocks Kv3 but not large-conductance calcium-activated potassium channels, enhanced evoked EPP amplitude. Unexpectedly, blood-depressing substance-I, a toxin selective for Kv3.4 subunits, had no effect at 0.05-1 microM. The combined presynaptic localization of Kv3 subunits and pharmacological enhancement of EPP amplitude indicate that Kv3 channels regulate neurotransmitter release from presynaptic terminals at the NMJ.

  3. Developmental regulation of voltage-sensitive sodium channels in rat skeletal muscle

    Sherman, S.J.


    The developmental regulation of the voltage-sensitive Na/sup +/ channel in rat skeletal muscle was studied in vivo and in vitro. In triceps surae muscle developing in vivo the development of TTX-sensitive Na/sup +/ channel occurred primarily during the first three postnatal weeks as determined by the specific binding of (/sup 3/H)saxitoxin. This development proceeded in two separate phases. The first phase occurs independently of continuing motor neuron innervation and accounts for 60% of the adult density of TTX-sensitive Na/sup +/ channels. The second phase, which begins about day 11, requires innervation. Muscle cells in primary culture were found to have both TTX-sensitive and insensitive Na/sup +/ channels. The development of the TTX-sensitive channel, in vitro, paralleled the initial innervation-independent phase of development observed in vivo. The density of TTX-sensitive Na/sup +/ channels in cultured muscle cells was regulated by electrical activity and cytosolic Ca/sup + +/ levels. Pharmacological blockade of the spontaneous electrical activity present in these cells lead to a nearly 2-fold increase in the surface density of TTX-sensitive channels. The turnover time of the TTX-sensitive Na/sup +/ channel was measured by blocking the incorporation of newly synthesized channels with tunicamycin, an inhibitor of N-linked protein glycosylation. The regulation of channel density by electrical activity, cytosolic Ca/sup + +/levels, and agents affecting cyclic neucleotide levels had no effect on the turnover time of the TTX-sensitive Na/sup +/ channel, indicating that these regulatory agents instead affect the synthesis of the channel.

  4. Differential CaMKII regulation by voltage-gated calcium channels in the striatum.

    Pasek, Johanna G; Wang, Xiaohan; Colbran, Roger J


    Calcium signaling regulates synaptic plasticity and many other functions in striatal medium spiny neurons to modulate basal ganglia function. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a major calcium-dependent signaling protein that couples calcium entry to diverse cellular changes. CaMKII activation results in autophosphorylation at Thr286 and sustained calcium-independent CaMKII activity after calcium signals dissipate. However, little is known about the mechanisms regulating striatal CaMKII. To address this, mouse brain slices were treated with pharmacological modulators of calcium channels and punches of dorsal striatum were immunoblotted for CaMKII Thr286 autophosphorylation as an index of CaMKII activation. KCl depolarization increased levels of CaMKII autophosphorylation ~2-fold; this increase was blocked by an LTCC antagonist and was mimicked by treatment with pharmacological LTCC activators. The chelation of extracellular calcium robustly decreased basal CaMKII autophosphorylation within 5min and increased levels of total CaMKII in cytosolic fractions, in addition to decreasing the phosphorylation of CaMKII sites in the GluN2B subunit of NMDA receptors and the GluA1 subunit of AMPA receptors. We also found that the maintenance of basal levels of CaMKII autophosphorylation requires low-voltage gated T-type calcium channels, but not LTCCs or R-type calcium channels. Our findings indicate that CaMKII activity is dynamically regulated by multiple calcium channels in the striatum thus coupling calcium entry to key downstream substrates.

  5. Design and implementation of a bidirectional current-controlled voltage-regulated DC-DC switched-mode converter

    Coetzer, A


    Full Text Available The design and implementation of a bidirectional current-controlled voltage-regulated DC-DC converter is presented. The converter is required to connect a battery of electrochemical cells (the battery) to an asynchronous motor-drive unit via a...

  6. Regulation of cough and action potentials by voltage-gated Na channels.

    Carr, Michael J


    The classical role ascribed to voltage-gated Na channels is the conduction of action potentials. Some excitable tissues such as cardiac muscle and skeletal muscle predominantly express a single voltage-gated Na channels isoform. Of the nine voltage-gated Na channels, seven are expressed in neurons, of these Nav 1.7, 1.8 and 1.9 are expressed in sensory neurons including vagal sensory neurons that innervate the airways and initiate cough. Nav 1.7 and Nav 1.9 are of particular interest as they represent two extremes in the functional diversity of voltage-gated Na channels. Voltage-gated Na channel isoforms expressed in airway sensory neurons produce multiple distinct Na currents that underlie distinct aspects of sensory neuron function. The interaction between voltage-gated Na currents underlies the characteristic ability of airway sensory nerves to encode encounters with irritant stimuli into action potential discharge and evoke the cough reflex.

  7. Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels.

    Fleidervish, Ilya A; Libman, Lior; Katz, Efrat; Gutnick, Michael J


    Because the excitable properties of neurons in the neocortex depend on the characteristics of voltage-gated Na(+) channels, factors which regulate those characteristics can fundamentally modify the dynamics of cortical circuits. Here, we report on a novel neuromodulatory mechanism that links the availability of Na(+) channels to metabolism of polyamines (PAs) in the cerebral cortex. Using single channel and whole-cell recordings, we found that products of PA metabolism, the ubiquitous aliphatic polycations spermine and spermidine, are endogenous blockers of Na(+) channels in layer 5 pyramidal cells. Because the blockade is activity-dependent, it is particularly effective against Na(+) channels which fail to inactivate rapidly and thus underlie the persistent Na(+) current. At the level of the local cortical circuit, pharmacological depletion of PAs led to increased spontaneous spiking and periods of hypersynchronous discharge. Our data suggest that changes in PA levels, whether associated with normal brain states or pathological conditions, profoundly modify Na(+) channel availability and thereby shape the integrative behavior of single neurons and neocortical circuits.

  8. Adaptive PI controller to voltage regulation in power systems: STATCOM as a case study.

    Tavana, Mohammad Reza; Khooban, Mohammad-Hassan; Niknam, Taher


    Static synchronous compensator (STATCOM) provides the means to improve quality and reliability of a power system as it has the functional capability to handle dynamic disturbances, such as transient stability and power oscillation damping as well as to providing voltage regulation. In this paper, a robust adaptive PI-based optimal fuzzy control strategy is proposed to control a STATCOM used in distribution systems. The proposed intelligent strategy is based on a combination of a new General Type-II Fuzzy Logic (GT2FL) with a simple heuristic algorithm named Teaching Learning Based Optimization (TLBO) Algorithm. The proposed framework optimally tunes parameters of a Proportional-Integral (PI) controller which, similar to most of other researchers regarding control of STATCOM, are in charge of controlling the device. The proposed controller guaranties robustness and stability against uncertainties caused by external disturbances or ever-changing nature of the power systems. The TLBO optimizes the parameters of the controller as well as the input and output membership functions. To validate the efficiency of the proposed controller, the obtained simulation results are compared with those of the two most recent researches applied in this field, namely, conventional Proportional Integral (PI) controller and Optimal Fuzzy PI (OFPI) controller. Results demonstrate the successfulness and effectiveness of the proposed online-TLBO General Type-2 Fuzzy PI (OGT2FPI) controller and its superiority over conventional approaches.

  9. Tunning PID controller using particle swarm optimization algorithm on automatic voltage regulator system

    Aranza, M. F.; Kustija, J.; Trisno, B.; Hakim, D. L.


    PID Controller (Proportional Integral Derivative) was invented since 1910, but till today still is used in industries, even though there are many kind of modern controllers like fuzz controller and neural network controller are being developed. Performance of PID controller is depend on on Proportional Gain (Kp), Integral Gain (Ki) and Derivative Gain (Kd). These gains can be got by using method Ziegler-Nichols (ZN), gain-phase margin, Root Locus, Minimum Variance dan Gain Scheduling however these methods are not optimal to control systems that nonlinear and have high-orde, in addition, some methods relative hard. To solve those obstacles, particle swarm optimization (PSO) algorithm is proposed to get optimal Kp, Ki and Kd. PSO is proposed because PSO has convergent result and not require many iterations. On this research, PID controller is applied on AVR (Automatic Voltage Regulator). Based on result of analyzing transient, stability Root Locus and frequency response, performance of PID controller is better than Ziegler-Nichols.

  10. The role of voltage-gated potassium channels in the regulation of mouse uterine contractility.

    Smith, Ryan C; McClure, Marisa C; Smith, Margaret A; Abel, Peter W; Bradley, Michael E


    Uterine smooth muscle cells exhibit ionic currents that appear to be important in the control of uterine contractility, but how these currents might produce the changes in contractile activity seen in pregnant myometrium has not been established. There are conflicting reports concerning the role of voltage-gated potassium (Kv) channels and large-conductance, calcium-activated potassium (BK) channels in the regulation of uterine contractility. In this study we provide molecular and functional evidence for a role for Kv channels in the regulation of spontaneous contractile activity in mouse myometrium, and also demonstrate a change in Kv channel regulation of contractility in pregnant mouse myometrium. Functional assays which evaluated the effects of channel blockers and various contractile agonists were accomplished by quantifying contractility of isolated uterine smooth muscle obtained from nonpregnant mice as well as mice at various stages of pregnancy. Expression of Kv channel proteins in isolated uterine smooth muscle was evaluated by Western blots. The Kv channel blocker 4-aminopyridine (4-AP) caused contractions in nonpregnant mouse myometrium (EC50 = 54 micromolar, maximal effect at 300 micromolar) but this effect disappeared in pregnant mice; similarly, the Kv4.2/Kv4.3 blocker phrixotoxin-2 caused contractions in nonpregnant, but not pregnant, myometrium. Contractile responses to 4-AP were not dependent upon nerves, as neither tetrodotoxin nor storage of tissues at room temperature significantly altered these responses, nor were responses dependent upon the presence of the endometrium. Spontaneous contractions and contractions in response to 4-AP did not appear to be mediated by BK, as the BK channel-selective blockers iberiotoxin, verruculogen, or tetraethylammonium failed to affect either spontaneous contractions or 4-AP-elicited responses. A number of different Kv channel alpha subunit proteins were found in isolated myometrium from both nonpregnant and

  11. The role of voltage-gated potassium channels in the regulation of mouse uterine contractility

    Abel Peter W


    Full Text Available Abstract Background Uterine smooth muscle cells exhibit ionic currents that appear to be important in the control of uterine contractility, but how these currents might produce the changes in contractile activity seen in pregnant myometrium has not been established. There are conflicting reports concerning the role of voltage-gated potassium (Kv channels and large-conductance, calcium-activated potassium (BK channels in the regulation of uterine contractility. In this study we provide molecular and functional evidence for a role for Kv channels in the regulation of spontaneous contractile activity in mouse myometrium, and also demonstrate a change in Kv channel regulation of contractility in pregnant mouse myometrium. Methods Functional assays which evaluated the effects of channel blockers and various contractile agonists were accomplished by quantifying contractility of isolated uterine smooth muscle obtained from nonpregnant mice as well as mice at various stages of pregnancy. Expression of Kv channel proteins in isolated uterine smooth muscle was evaluated by Western blots. Results The Kv channel blocker 4-aminopyridine (4-AP caused contractions in nonpregnant mouse myometrium (EC50 = 54 micromolar, maximal effect at 300 micromolar but this effect disappeared in pregnant mice; similarly, the Kv4.2/Kv4.3 blocker phrixotoxin-2 caused contractions in nonpregnant, but not pregnant, myometrium. Contractile responses to 4-AP were not dependent upon nerves, as neither tetrodotoxin nor storage of tissues at room temperature significantly altered these responses, nor were responses dependent upon the presence of the endometrium. Spontaneous contractions and contractions in response to 4-AP did not appear to be mediated by BK, as the BK channel-selective blockers iberiotoxin, verruculogen, or tetraethylammonium failed to affect either spontaneous contractions or 4-AP-elicited responses. A number of different Kv channel alpha subunit proteins were

  12. Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.

    Aman, Teresa K; Grieco-Calub, Tina M; Chen, Chunling; Rusconi, Raffaella; Slat, Emily A; Isom, Lori L; Raman, Indira M


    The beta subunits of voltage-gated Na channels (Scnxb) regulate the gating of pore-forming alpha subunits, as well as their trafficking and localization. In heterologous expression systems, beta1, beta2, and beta3 subunits influence inactivation and persistent current in different ways. To test how the beta4 protein regulates Na channel gating, we transfected beta4 into HEK (human embryonic kidney) cells stably expressing Na(V)1.1. Unlike a free peptide with a sequence from the beta4 cytoplasmic domain, the full-length beta4 protein did not block open channels. Instead, beta4 expression favored open states by shifting activation curves negative, decreasing the slope of the inactivation curve, and increasing the percentage of noninactivating current. Consequently, persistent current tripled in amplitude. Expression of beta1 or chimeric subunits including the beta1 extracellular domain, however, favored inactivation. Coexpressing Na(V)1.1 and beta4 with beta1 produced tiny persistent currents, indicating that beta1 overcomes the effects of beta4 in heterotrimeric channels. In contrast, beta1(C121W), which contains an extracellular epilepsy-associated mutation, did not counteract the destabilization of inactivation by beta4 and also required unusually large depolarizations for channel opening. In cultured hippocampal neurons transfected with beta4, persistent current was slightly but significantly increased. Moreover, in beta4-expressing neurons from Scn1b and Scn1b/Scn2b null mice, entry into inactivated states was slowed. These data suggest that beta1 and beta4 have antagonistic roles, the former favoring inactivation, and the latter favoring activation. Because increased Na channel availability may facilitate action potential firing, these results suggest a mechanism for seizure susceptibility of both mice and humans with disrupted beta1 subunits.

  13. Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins

    Rougier, Jean-Sébastien; van Bemmelen, Miguel X; Bruce, M Christine


    -ubiquitin ligases of the Nedd4 family. We recently reported that cardiac Na(v)1.5 is regulated by Nedd4-2. In this study, we further investigated the molecular determinants of regulation of Na(v) proteins. When expressed in HEK-293 cells and studied using whole cell voltage clamping, the neuronal Na(v)1.2 and Na......The voltage-gated Na(+) channels (Na(v)) form a family composed of 10 genes. The COOH termini of Na(v) contain a cluster of amino acids that are nearly identical among 7 of the 10 members. This COOH-terminal sequence, PPSYDSV, is a PY motif known to bind to WW domains of E3 protein...... that Nedd4-dependent ubiquitination of Na(v) channels may represent a general mechanism regulating the excitability of neurons and myocytes via modulation of channel density at the plasma membrane....

  14. SEMICONDUCTOR INTEGRATED CIRCUITS: A full on-chip CMOS low-dropout voltage regulator with VCCS compensation

    Leisheng, Gao; Yumei, Zhou; Bin, Wu; Jianhua, Jiang


    A full on-chip CMOS low-dropout (LDO) voltage regulator with high PSR is presented. Instead of relying on the zero generated by the load capacitor and its equivalent series resistance, the proposed LDO generates a zero by voltage-controlled current sources for stability. The compensating capacitor for the proposed scheme is only 0.18 pF, which is much smaller than the capacitor of the conventional compensation scheme. The full on-chip LDO was fabricated in commercial 0.35 μm CMOS technology. The active chip area of the LDO (including the bandgap voltage reference) is 400 × 270 μm2. Experimental results show that the PSR of the LDO is -58.7 dB at a frequency of 10 Hz and -20 dB at a frequency of 1 MHz. The proposed LDO is capable of sourcing an output current up to 50 mA.

  15. Development of Voltage Regulation Plan by Composing Subsystem with the SFES for DC On-line Electric Vehicle

    Jung, S.; Lee, J. H.; Yoon, M.; Lee, H.; Jang, G.

    The study of the application process of the relatively small size 'Superconducting Flywheel Energy Storage (SFES)' system is conducted to regulate voltage fluctuation of the DC On-Line Electric Vehicle (OLEV) system, which is designed by using DC power system network. It is recommended to construct the power conversion system nearby the substation because the charging system is under the low voltage. But as the system is usually built around urban area and it makes hard to construct the subsystems at every station, voltage drop can occur in power supply inverter that is some distance from the substation. As the alternative of this issue, DC distribution system is recently introduced and has possibility to solve the above issue. In this paper, SFES is introduced to solve the voltage drop under the low voltage distribution system by using the concept of the proposed DC OLEV which results in building the longer distance power supply system. The simulation to design the SFES by using DC power flow analysis is carried out and it is verified in this paper.

  16. On-line monitoring of base current and forward emitter current gain of the voltage regulator's serial pnp transistor in a radiation environment

    Vukić Vladimir Đ.


    Full Text Available A method of on-line monitoring of the low-dropout voltage regulator's operation in a radiation environment is developed in this paper. The method had to enable detection of the circuit's degradation during exploitation, without terminating its operation in an ionizing radiation field. Moreover, it had to enable automatic measurement and data collection, as well as the detection of any considerable degradation, well before the monitored voltage regulator's malfunction. The principal parameters of the voltage regulator's operation that were monitored were the serial pnp transistor's base current and the forward emitter current gain. These parameters were procured indirectly, from the data on the voltage regulator's load and quiescent currents. Since the internal consumption current in moderately and heavily loaded devices was used, the quiescent current of a negligibly loaded voltage regulator of the same type served as a reference. Results acquired by on-line monitoring demonstrated marked agreement with the results acquired from examinations of the voltage regulator's maximum output current and minimum dropout voltage in a radiation environment. The results were particularly consistent in tests with heavily loaded devices. Results obtained for moderately loaded voltage regulators and the risks accompanying the application of the presented method, were also analyzed.

  17. Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels.

    Suh, Byung-Chang; Kim, Dong-Il; Falkenburger, Björn H; Hille, Bertil


    The β-subunits of voltage-gated Ca(2+) (Ca(V)) channels regulate the functional expression and several biophysical properties of high-voltage-activated Ca(V) channels. We find that Ca(V) β-subunits also determine channel regulation by the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)). When Ca(V)1.3, -2.1, or -2.2 channels are cotransfected with the β3-subunit, a cytosolic protein, they can be inhibited by activating a voltage-sensitive lipid phosphatase to deplete PIP(2). When these channels are coexpressed with a β2a-subunit, a palmitoylated peripheral membrane protein, the inhibition is much smaller. PIP(2) sensitivity could be increased by disabling the two palmitoylation sites in the β2a-subunit. To further test effects of membrane targeting of Ca(V) β-subunits on PIP(2) regulation, the N terminus of Lyn was ligated onto the cytosolic β3-subunit to confer lipidation. This chimera, like the Ca(V) β2a-subunit, displayed plasma membrane localization, slowed the inactivation of Ca(V)2.2 channels, and increased the current density. In addition, the Lyn-β3 subunit significantly decreased Ca(V) channel inhibition by PIP(2) depletion. Evidently lipidation and membrane anchoring of Ca(V) β-subunits compete with the PIP(2) regulation of high-voltage-activated Ca(V) channels. Compared with expression with Ca(V) β3-subunits alone, inhibition of Ca(V)2.2 channels by PIP(2) depletion could be significantly attenuated when β2a was coexpressed with β3. Our data suggest that the Ca(V) currents in neurons would be regulated by membrane PIP(2) to a degree that depends on their endogenous β-subunit combinations.

  18. A fully on-chip fast-transient NMOS low dropout voltage regulator with quasi floating gate pass element

    Wang, Han; Gou, Chao; Luo, Kai


    This paper presents a fully on-chip NMOS low-dropout regulator (LDO) for portable applications with quasi floating gate pass element and fast transient response. The quasi floating gate structure makes the gate of the NMOS transistor only periodically charged or refreshed by the charge pump, which allows the charge pump to be a small economical circuit with small silicon area. In addition, a variable reference circuit is introduced enlarging the dynamic range of error amplifier during load transient. The proposed LDO has been implemented in a 0.35 μm BCD process. From experimental results, the regulator can operate with a minimum dropout voltage of 250 mV at a maximum 1 A load and {I}{{Q}} of 395 μA. Under full-range load current step, the voltage undershoot and overshoot of the proposed LDO are reduced to 50 and 26 mV, respectively.

  19. Regulation of the voltage-insensitive step of HERG activation by extracellular pH.

    Zhou, Qinlian; Bett, Glenna C L


    Human ether-à-go-go-related gene (HERG, Kv11.1, KCNH2) voltage-gated K(+) channels dominate cardiac action potential repolarization. In addition, HERG channels play a role in neuronal and smooth cell excitability as well as cancer pathology. Extracellular pH (pH(o)) is modified during myocardial ischemia, inflammation, and respiratory alkalosis, so understanding the response of HERG channels to changes in pH is of clinical significance. The relationship between pH(o) and HERG channel gating appears complex. Acidification has previously been reported to speed, slow, or have no effect on activation. We therefore undertook comprehensive analysis of the effect of pH(o) on HERG channel activation. HERG channels have unique and complex activation gating characteristics with both voltage-sensitive and voltage-insensitive steps in the activation pathway. Acidosis decreased the activation rate, suppressed peak current, and altered the sigmoidicity of gating near threshold potentials. At positive voltages, where the voltage-insensitive transition is rate limiting, pH(o) modified the voltage-insensitive step with a pK(a) similar to that of histidine. Hill coefficient analysis was incompatible with a coefficient of 1 but was well described by a Hill coefficient of 4. We derived a pH(o)-sensitive term for a five-state Markov model of HERG channel gating. This model demonstrates the mechanism of pH(o) sensitivity in HERG channel activation. Our experimental data and mathematical model demonstrate that the pH(o) sensitivity of HERG channel activation is dominated by the pH(o) sensitivity of the voltage-insensitive step, in a fashion that is compatible with the presence of at least one proton-binding site on each subunit of the channel tetramer.

  20. A Voltage Regulator for Parallel Operated Isolated Synchronous Generators Using Statcom

    Sravanthi Gudipati,


    Full Text Available Reactive power (vars is required to maintain the voltage to deliver active power through transmission lines. Generator and other loads require reactive power to convert the flow of electrons into useful work. When there is not enough reactive power, the voltage sags down and it is not possible to push the power demanded by loads through the lines. Thus reactive power is injected using the compensating device STATCOM.The Paper deals on static synchronous compensator (STATCOM which is connected to the parallel operated isolated synchronous generators to drive a 3-phase load. These generators are driven by constant prime mover like diesel engine,bio-mass,gasoline,steam turbine etc.Three single phase IGBT based Voltage source converter (VSC along with 3-single phase transformers and self supported D.C bus is used as a voltage controller. The project deals with controlling a STATCOM using non-linear techniques that involves hysteresis current control and Park’s transformation. The voltage controller of parallel operated generators for feeding 3-phase loads driven by constant speed prime mover like Hydraulic turbine governor model helps in satisfactory operation under varying loads and in load balancing. If the line current is less than the expected, the compensating current generated by STATCOM is taken by loads.

  1. A 5 V-to-3.3 V CMOS Linear Regulator with Three-Output Temperature-Independent Reference Voltages

    San-Fu Wang


    Full Text Available This paper presents a 5 V-to-3.3 V linear regulator circuit, which uses 3.3 V CMOS transistors to replace the 5 V CMOS transistors. Thus, the complexity of the manufacturing semiconductor process can be improved. The proposed linear regulator is implemented by cascode architecture, which requires three different reference voltages as the bias voltages of its circuit. Thus, the three-output temperature-independent reference voltage circuit is proposed, which provides three accurate reference voltages simultaneously. The three-output temperature-independent reference voltages also can be used in other circuits of the chip. By using the proposed temperature-independent reference voltages, the proposed linear regulator can provide an accurate output voltage, and it is suitable for low cost, small size, and highly integrated system-on-chip (SoC applications. Moreover, the proposed linear regulator uses the cascode technique, which improves both the gain performance and the isolation performance. Therefore, the proposed linear regulator has a good performance in reference voltage to output voltage isolation. The voltage variation of the linear regulator is less than 2.153% in the temperature range of −40°C–120°C, and the power supply rejection ratio (PSRR is less than −42.8 dB at 60 Hz. The regulator can support 0~200 mA output current. The core area is less than 0.16 mm2.

  2. Single-channel properties of the reconstituted voltage-regulated Na channel isolated from the electroplax of Electrophorus electricus.

    Rosenberg, R L; Tomiko, S A; Agnew, W S


    The tetrodotoxin-binding protein purified from electroplax of Electrophorus electricus has been reincorporated into multilamellar vesicles that were used for patch recording. When excised patches of these reconstituted membranes were voltage clamped in the absence of neurotoxins, voltage-dependent single-channel currents were recorded. These displayed properties qualitatively and quantitatively similar to those reported for Na channels from nerve and muscle cells, including uniform single-channel conductances of the appropriate magnitude (approximately equal to 11 pS in 95 mM Na+), mean open times of approximately equal to 1.9 msec, and 7-fold selectively for Na+ over K+. Currents averaged from many depolarizations showed initial voltage-dependent activation and subsequent inactivation. In the presence of batrachotoxin, channels were observed with markedly different properties, including conductances of 20-25 pS (95 mM Na+), mean open times of approximately equal to 28 msec, and no indication of inactivation. Collectively, these findings indicate that the tetrodotoxin-binding protein of electroplax is a voltage-regulated sodium channel. PMID:6089214

  3. Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.

    Mistry, Hiten D; McCallum, Laura A; Kurlak, Lesia O; Greenwood, Iain A; Broughton Pipkin, Fiona; Tribe, Rachel M


    Preeclampsia is associated with structural/functional alterations in placental and maternal vasculature. Voltage-dependant potassium channels encoded by KCNQ1-5 genes have been detected in several types of blood vessels where they promote vascular relaxation. Voltage-dependant potassium channel function can be modulated by KCNE1-5-encoded accessory proteins. The aim of this study was to determine whether KCNQ and KCNE genes are differentially expressed in placentas from women with preeclampsia compared with normotensive controls and to examine any differences in those who delivered preterm (voltage-dependant potassium channels are expressed and markedly modulated in placentas from preeclamptic women. Differential expression of isoforms may lead to altered cell proliferation. The correlation between KCNQ3 and KCNE5 expression is indicative of a novel channel complex and warrants further investigation.

  4. Calmodulin and calcium differentially regulate the neuronal Nav1.1 voltage-dependent sodium channel

    Gaudioso, Christelle; Carlier, Edmond; Youssouf, Fahamoe [INSERM U641, Institut Jean Roche, Marseille F-13344 (France); Universite de la Mediterranee, Faculte de Medecine Secteur Nord, IFR 11, Marseille F-13344 (France); Clare, Jeffrey J. [Eaton Pharma Consulting, Eaton Socon, Cambridgeshire PE19 8EF (United Kingdom); Debanne, Dominique [INSERM U641, Institut Jean Roche, Marseille F-13344 (France); Universite de la Mediterranee, Faculte de Medecine Secteur Nord, IFR 11, Marseille F-13344 (France); Alcaraz, Gisele, E-mail: [INSERM U641, Institut Jean Roche, Marseille F-13344 (France); Universite de la Mediterranee, Faculte de Medecine Secteur Nord, IFR 11, Marseille F-13344 (France)


    Highlights: {yields} Both Ca{sup ++}-Calmodulin (CaM) and Ca{sup ++}-free CaM bind to the C-terminal region of Nav1.1. {yields} Ca{sup ++} and CaM have both opposite and convergent effects on I{sub Nav1.1}. {yields} Ca{sup ++}-CaM modulates I{sub Nav1.1} amplitude. {yields} CaM hyperpolarizes the voltage-dependence of activation, and increases the inactivation rate. {yields} Ca{sup ++} alone antagonizes CaM for both effects, and depolarizes the voltage-dependence of inactivation. -- Abstract: Mutations in the neuronal Nav1.1 voltage-gated sodium channel are responsible for mild to severe epileptic syndromes. The ubiquitous calcium sensor calmodulin (CaM) bound to rat brain Nav1.1 and to the human Nav1.1 channel expressed by a stably transfected HEK-293 cell line. The C-terminal region of the channel, as a fusion protein or in the yeast two-hybrid system, interacted with CaM via a consensus C-terminal motif, the IQ domain. Patch clamp experiments on HEK1.1 cells showed that CaM overexpression increased peak current in a calcium-dependent way. CaM had no effect on the voltage-dependence of fast inactivation, and accelerated the inactivation kinetics. Elevating Ca{sup ++} depolarized the voltage-dependence of fast inactivation and slowed down the fast inactivation kinetics, and for high concentrations this effect competed with the acceleration induced by CaM alone. Similarly, the depolarizing action of calcium antagonized the hyperpolarizing shift of the voltage-dependence of activation due to CaM overexpression. Fluorescence spectroscopy measurements suggested that Ca{sup ++} could bind the Nav1.1 C-terminal region with micromolar affinity.

  5. Principle and Fault Analysis of Voltage Regulator Circuit%电压调节器电路原理及故障分析



    Firstly, the paper explores the essential characteristics of voltage regulator through experiments, and then analyzes the circuit principle of the voltage regulator. The paper finally discusses the fault analysis method of voltage regulator circuit through the cases.%本文首先通过实验探究电压调节器的本质特性,然后分析电压调节器电路原理,最后通过案例探究电压调节器电路的故障分析方法.

  6. General and Simple Decision Method for DG Penetration Level in View of Voltage Regulation at Distribution Substation Transformers

    Joon-Ho Choi


    Full Text Available A distribution system was designed and operated by considering unidirectional power flow from a utility source to end-use loads. The large penetrations of distributed generation (DG into the existing distribution system causes a variety of technical problems, such as frequent tap changing problems of the on-load tap changer (OLTC transformer, local voltage rise, protection coordination, exceeding short-circuit capacity, and harmonic distortion. In view of voltage regulation, the intermittent fluctuation of the DG output power results in frequent tap changing operations of the OLTC transformer. Thus, many utilities limit the penetration level of DG and are eager to find the reasonable penetration limits of DG in the distribution system. To overcome this technical problem, utilities have developed a new voltage regulation method in the distribution system with a large DG penetration level. In this paper, the impact of DG on the OLTC operations controlled by the line drop compensation (LDC method is analyzed. In addition, a generalized determination methodology for the DG penetration limits in a distribution substation transformer is proposed. The proposed DG penetration limits could be adopted for a simplified interconnection process in DG interconnection guidelines.

  7. Allocation of Capacitors and Voltage Regulators in Unbalanced Distribution Systems: A Multi-objective Problem in Probabilistic Frameworks

    Carpinelli, Guido; Noce, Christian; Russo, Angela; Varilone, Pietro


    Capacitors and series voltage regulators are used extensively in distribution systems to reduce power losses and improve the voltage profile along the feeders. This paper deals with the problem of contemporaneously choosing optimal locations and sizes for both capacitors and series voltage regulators in three-phase, unbalanced distribution systems. This is a mixed, non-linear, constrained, multi-objective optimization problem that usually is solved in deterministic scenarios. However, distribution systems are stochastic in nature, which can lead to inaccurate deterministic solutions. To take into account the unavoidable uncertainties that affect the input data related to the problem, in this paper, we have formulated and solved the multi-objective optimization problem in probabilistic scenarios. To address the multi-objective optimization problem, algorithms were used in which all the objective functions were combined to form a single function. These algorithms allow us to transform the original multi-objective optimization problem into an equivalent, single-objective, optimization problem, an approach that appeared to be particularly suitable since computational time was an important issue. To further reduce the computational efforts, a linearized form of the equality constraints of the optimization model was used, and a micro-genetic algorithm-based procedure was applied in the solution method.

  8. Regulation of Voltage-Gated K+ Channel Kv1.5 by the Janus Kinase JAK3.

    Warsi, Jamshed; Elvira, Bernat; Bissinger, Rosi; Hosseinzadeh, Zohreh; Lang, Florian


    The tyrosine kinase Janus kinase 3 (JAK3) participates in the regulation of cell proliferation and apoptosis. The kinase further influences ion channels and transport proteins. The present study explored whether JAK3 contributes to the regulation of the voltage-gated K(+) channel Kv1.5, which participates in the regulation of diverse functions including atrial cardiac action potential and tumor cell proliferation. To this end, cRNA encoding Kv1.5 was injected into Xenopus oocytes with or without additional injection of cRNA encoding wild-type JAK3, constitutively active (A568V)JAK3, or inactive (K851A)JAK3. Voltage-gated K(+) channel activity was measured utilizing dual electrode voltage clamp, and Kv1.5 channel protein abundance in the cell membrane was quantified utilizing chemiluminescence of Kv1.5 containing an extracellular hemagglutinin epitope (Kv1.5-HA). As a result, Kv1.5 activity and Kv1.5-HA protein abundance were significantly decreased by wild-type JAK3 and (A568V)JAK3, but not by (K851A)JAK3. Inhibition of Kv1.5 protein insertion into the cell membrane by brefeldin A (5 μM) resulted in a decline of the voltage-gated current, which was similar in the absence and presence of (A568V)JAK3, suggesting that (A568V)JAK3 did not accelerate Kv1.5 protein retrieval from the cell membrane. A 24 h treatment with ouabain (100 µM) significantly decreased the voltage-gated current in oocytes expressing Kv1.5 without or with (A568V)JAK3 and dissipated the difference between oocytes expressing Kv1.5 alone and oocytes expressing Kv1.5 with (A568V)JAK3. In conclusion, JAK3 contributes to the regulation of membrane Kv1.5 protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase activity.

  9. Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.

    Sun, Xiaohui; Zaydman, Mark A; Cui, Jianmin


    Voltage-activated K(+) (K(V)) channels are important for shaping action potentials and maintaining resting membrane potential in excitable cells. K(V) channels contain a central pore-gate domain (PGD) surrounded by four voltage-sensing domains (VSDs). The VSDs will change conformation in response to alterations of the membrane potential thereby inducing the opening of the PGD. Many K(V) channels are heteromeric protein complexes containing auxiliary β subunits. These β subunits modulate channel expression and activity to increase functional diversity and render tissue specific phenotypes. This review focuses on the K(V) β subunits that contain transmembrane (TM) segments including the KCNE family and the β subunits of large conductance, Ca(2+)- and voltage-activated K(+) (BK) channels. These TM β subunits affect the voltage-dependent activation of K(V) α subunits. Experimental and computational studies have described the structural location of these β subunits in the channel complexes and the biophysical effects on VSD activation, PGD opening, and VSD-PGD coupling. These results reveal some common characteristics and mechanistic insights into K(V) channel modulation by TM β subunits.

  10. Regulation of KV channel voltage-dependent activation by transmembrane β subunits

    Xiaohui eSun


    Full Text Available Voltage-activated K+ (KV channels are important for shaping action potentials and maintaining resting membrane potential in excitable cells. KV channels contain a central pore-gate domain (PGD surrounded by four voltage-sensing domains (VSD. The VSDs will change conformation in response to alterations of the membrane potential thereby inducing the opening of the PGD. Many KV channels are heteromeric protein complexes containing auxiliary β subunits. These β subunits modulate channel expression and activity to increase functional diversity and render tissue specific phenotypes. This review focuses on the KV β subunits that contain transmembrane (TM segments including the KCNE family and the β subunits of large conductance, Ca2+- and voltage-activated K+ (BK channels. These TM β subunits affect the voltage-dependent activation of KV α subunits. Experimental and computational studies have described the structural location of these β subunits in the channel complexes and the biophysical effects on VSD activation, PGD opening and VSD-PGD coupling. These results reveal some common characteristics and mechanistic insights into KV channel modulation by TM β subunits.

  11. Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels.

    Zhang, Yun; Chen, Yu-Hang; Bangaru, Saroja D; He, Linling; Abele, Kathryn; Tanabe, Shihori; Kozasa, Tohru; Yang, Jian


    G-protein (Gbetagamma)-mediated voltage-dependent inhibition of N- and P/Q-type Ca(2+) channels contributes to presynaptic inhibition and short-term synaptic plasticity. The voltage dependence derives from the dissociation of Gbetagamma from the inhibited channels, but the underlying molecular and biophysical mechanisms remain largely unclear. In this study we investigated the role in this process of Ca(2+) channel beta subunit (Ca(v)beta) and a rigid alpha-helical structure between the alpha-interacting domain (AID), the primary Ca(v)beta docking site on the channel alpha(1) subunit, and the pore-lining IS6 segment. Gbetagamma inhibition of P/Q-type channels was reconstituted in giant inside-out membrane patches from Xenopus oocytes. Large populations of channels devoid of Ca(v)beta were produced by washing out a mutant Ca(v)beta with a reduced affinity for the AID. These beta-less channels were still inhibited by Gbetagamma, but without any voltage dependence, indicating that Ca(v)beta is indispensable for voltage-dependent Gbetagamma inhibition. A truncated Ca(v)beta containing only the AID-binding guanylate kinase (GK) domain could fully confer voltage dependence to Gbetagamma inhibition. Gbetagamma did not alter inactivation properties, and channels recovered from Gbetagamma inhibition exhibited the same activation property as un-inhibited channels, indicating that Gbetagamma does not dislodge Ca(v)beta from the inhibited channel. Furthermore, voltage-dependent Gbetagamma inhibition was abolished when the rigid alpha-helix between the AID and IS6 was disrupted by insertion of multiple glycines, which also eliminated Ca(v)beta regulation of channel gating, revealing a pivotal role of this rigid alpha-helix in both processes. These results suggest that depolarization-triggered movement of IS6, coupled to the subsequent conformational change of the Gbetagamma-binding pocket through a rigid alpha-helix induced partly by the Ca(v)beta GK domain, causes the

  12. High-Performance Harmonic Isolation and Load Voltage Regulation of the Three-Phase Series Active Filter Utilizing the Waveform Reconstruction Method

    Senturk, Osman Selcuk; Hava, Ahmet M.


    . The SAF-compensated system utilizing WRM provides highperformance load harmonic voltage isolation and load voltage regulation at steady-state and during transients compared to the system utilizing the synchronous reference-frame-based signal decomposition. In addition, reducing the line current sampling......This paper develops a waveform reconstruction method (WRM) for high accuracy and bandwidth signal decomposition of voltage-harmonic-type three-phase diode rectifier load voltage into its harmonic and fundamental components, which are utilized in the series active filter (SAF) control algorithms...

  13. Design of Digital Voltage Regulator Based on DSP%基于DSP的数字发电机调压器设计

    管定铕; 张晓斌; 郑先成


    In order to overcome shortcomings which is brought by traditional analog voltage regulator, a DSP-based digital voltage regulator design is presented. In this paper,the hardware and software design of the voltage regulator is introduced in detail, and a tested system was developed. Experiences show that various performance of the voltage regulator meets the requirements of GJB181 A.%为了克服传统模拟调压器带来的缺点,提出了一种基于DSP的数字调压器的设计方案.介绍了硬件和软件的设计,并构建实验验证系统检测调压器的性能.实验证明该调压器的各项性能指标能够满足GJB181A的要求.

  14. Voltage-sensing phosphatase reveals temporal regulation of TRPC3/C6/C7 channels by membrane phosphoinositides.

    Itsuki, Kyohei; Imai, Yuko; Okamura, Yasushi; Abe, Kihachiro; Inoue, Ryuji; Mori, Masayuki X


    TRPC3/C6/C7 channels, a subgroup of classical/canonical TRP channels, are activated by diacylglycerol produced via activation of phospholipase C (PLC)-coupled receptors. Recognition of the physiological importance of these channels has been steadily growing, but the mechanism by which they are regulated remains largely unknown. We recently used a membrane-resident danio rerio voltage-sensing phosphatase (DrVSP) to study TRPC3/C6/C7 regulation and found that the channel activity was controlled by PtdIns(4,5)P(2)-DAG signaling in a self-limiting manner (Imai Y et al., the Journal of Physiology, 2012). In this addendum, we present the advantages of using DrVSP as a molecular tool to study PtdIns(4,5)P(2) regulation. DrVSP should be readily applicable for studying phosphoinositide metabolism-linked channel regulation as well as lipid dynamics. Furthermore, in comparison to other modes of self-limiting ion channel regulation, the regulation of TRPC3/C6/C7 channels seems highly susceptible to activation signal strength, which could potentially affect both open duration and the time to peak activation and inactivation. Dysfunction of such self-limiting regulation may contribute to the pathology of the cardiovascular system, gastrointestinal tract and brain, as these channels are broadly distributed and affected by numerous neurohormonal agonists.

  15. Interval Type-II Fuzzy Rule-Based STATCOM for Voltage Regulation in the Power System

    Ying-Yi Hong


    Full Text Available The static synchronous compensator (STATCOM has recently received much attention owing to its ability to stabilize power systems and mitigate voltage variations. This paper investigates a novel interval type-II fuzzy rule-based PID (proportional-integral-derivative controller for the STATCOM to mitigate bus voltage variations caused by large changes in load and the intermittent generation of photovoltaic (PV arrays. The proposed interval type-II fuzzy rule base utilizes the output of the PID controller to tune the signal applied to the STATCOM. The rules involve upper and lower membership functions that ensure the stable responses of the controlled system. The proposed method is implemented using the NEPLAN software package and MATLAB/Simulink with co-simulation. A six-bus system is used to show the effectiveness of the proposed method. Comparative studies show that the proposed method is superior to traditional PID and type-I fuzzy rule-based methods.

  16. Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia

    Aras, Mandar A.; Saadi, Robert A.; Aizenman, Elias


    The delayed-rectifier K+ channel Kv2.1 exists in highly phosphorylated somatodendritic clusters. Ischemia induces rapid Kv2.1 dephosphorylation and a dispersal of these clusters, accompanied by a hyperpolarizing shift in their voltage-dependent activation kinetics. Transient modulation of Kv2.1 activity and localization following ischemia is dependent on a rise in intracellular Ca2+and the protein phosphatase calcineurin. Here, we show that neuronal free Zn2+also plays a critical role in the ...

  17. A new method for compensation of the effect of charging transformer's leakage inductance on PFN voltage regulation in Klystron pulse modulators

    Patel, Akhil; Kale, Umesh; Shrivastava, Purushottam


    The Line type modulators have been widely used to generate high voltage rectangular pulses to power the klystron for high power RF generation. In Line type modulator, the Pulse Forming Network (PFN) which is a cascade combination of lumped capacitors and inductors is used to store the electrical energy. The charged PFN is then discharged into a klystron by firing a high voltage Thyratron switch. This discharge generates a high voltage rectangular pulse across the klystron electrodes. The amplitude and phase of Klystron's RF output is governed by the high voltage pulse amplitude. The undesired RF amplitude and phase stability issues arises at the klystron's output due to inter-pulse and during the pulse amplitude variations. To reduce inter-pulse voltage variations, the PFN is required to be charged at the same voltage after every discharge cycle. At present, the combination of widely used resonant charging and deQing method is used to regulate the pulse to pulse PFN voltage variations but the charging transformer's leakage inductance puts an upper bound on the regulation achievable by this method. Here we have developed few insights of the deQing process and devised a new compensation method to compensate this undesired effect of charging transformer's leakage inductance on the pulse to pulse PFN voltage stability. This compensation is accomplished by the controlled partial discharging of the split PFN capacitor using a low voltage MOSFET switch. Theoretically, very high values of pulse to pulse voltage stability may be achieved using this method. This method may be used in deQing based existing modulators or in new modulators, to increase the pulse to pulse voltage stability, without having a very tight bound on charging transformer's leakage inductance. Given a stable charging power supply, this method may be used to further enhance the inter-pulse voltage stability of modulators which employ the direct charging, after replacing the direct charging with the

  18. Flexible Power Regulation and Current-limited Control of Grid-connected Inverter under Unbalanced Grid Voltage Faults

    Guo, Xiaoqiang; Liu, Wenzhao; Lu, Zhigang


    The grid-connected inverters may experience excessive current stress in case of unbalanced grid voltage Fault Ride Through (FRT), which significantly affects the reliability of the power supply system. In order to solve the problem, the inherent mechanisms of the excessive current phenomenon...... with the conventional FRT solutions are discussed. The quantitative analysis of three phase current peak values are conducted and a novel current-limited control strategy is proposed to achieve the flexible active and reactive power regulation and successful FRT in a safe current operation area with the aim...

  19. Neural network-based voltage regulator for an isolated asynchronous generator supplying three-phase four-wire loads

    Singh, Bhim; Kasal, Gaurav Kumar [Department of Electrical Engineering, Indian Institute of Technology, Delhi, Hauz-Khas, New Delhi 110016 (India)


    This paper deals with a neural network-based solid state voltage controller for an isolated asynchronous generator (IAG) driven by constant speed prime mover like diesel engine, bio-gas or gasoline engine and supplying three-phase four-wire loads. The proposed control scheme uses an indirect current control and a fast adaptive linear element (adaline) based neural network reference current extractor, which extracts the real positive sequence current component without any phase shift. The neutral current of the source is also compensated by using three single-phase bridge configuration of IGBT (insulated gate bipolar junction transistor) based voltage source converter (VSC) along-with single-phase transformer having self-supported dc bus. The proposed controller provides the functions as a voltage regulator, a harmonic eliminator, a neutral current compensator, and a load balancer. The proposed isolated electrical system with its controller is modeled and simulated in MATLAB along with Simulink and PSB (Power System Block set) toolboxes. The simulated results are presented to demonstrate the capability of an isolated asynchronous generating system driven by a constant speed prime mover for feeding three-phase four-wire loads. (author)

  20. Differential regulation of voltage- and calcium-activated potassium channels in human B lymphocytes.

    Partiseti, M; Choquet, D; Diu, A; Korn, H


    The expression and characteristics of K+ channels of human B lymphocytes were studied by using single and whole-cell patch-clamp recordings. They were gated by depolarization (voltage-gated potassium current, IKv, 11-20 pS) and by an increase in intracellular Ca2+ concentration (calcium-activated potassium current, IKCa, 26 pS), respectively. The level of expression of these channels was correlated with the activational status of the cell. Both conductances are blocked by tetraethylammonium, verapamil, and charybdotoxin, and are insensitive to apamin; 4-aminopyridine blocks IK, preferentially. We used a protein kinase C activator (PMA) or antibodies to membrane Ig (anti-mu) to activate resting splenocytes in culture. Although IKv was recorded in the majority of the resting lymphocytic population, less than 20% of the activated cells expressed this conductance. However, in this subset the magnitude of IKv was 20-fold larger than in resting cells. On the other hand, IKCa was detected in nearly one half of the resting cells, whereas all activated cells expressed this current. The magnitude of IKCa was, on average, 30 times larger in activated than in nonactivated cells. These results probably reflect that during the course of activation 1) the number of voltage-dependent K+ channels per cell decreases and increases in a small subset and 2) the number of Ca(2+)-dependent K+ channels per cell increases in all cells. We suggest that the expression of functional Ca(2+)- and voltage-activated K+ channels are under the control of different regulatory signals.

  1. Research on Mechanism of Overcurrent and Overvoltage When Contactless Tap Changer Switch Regulates Voltage on Load


    Analyzes the mechanism of overvoltage when contactless tap changer switch which is applied in distributing transformer converted directly.When the device convert the tap-off,it employs the way that the SSR is switched on when voltage through zero and switched off when current through zero.But in the experiment we found that overvoltage will occur in the process of changing tap changer.The paper illustrates the mechanism of overvoltage in theory by analyzing the equivalent circuit and using analytic method of transition process.

  2. A Survey of High Performance AC Voltage Regulating Technologies%高性能交流电压调节技术的发展概况

    刘汉奎; 顾建军; 徐殿国; 王炎


    分析了交流斩波型、单位功率因数变换器 型和串联 型三类开关型交流电压调节装置,并给出了它们的新型拓扑结构。通过对这三种电压调节装 置的对比研究,指出串联型电压调节装置的性能价格比高于其他方式。串并联型电压调节装 置是交流电压调节装置的一个发展方向。%AC chopping voltage regulator,voltage regulator with unity power factor converter and series voltage regulator are analyzed,an d new topologies of each method are shown in this paper.It is pointed out that s eries voltage regulator has higher performance cost ratio,and series and parall el voltage regulator is a trend of AC voltage regulator.

  3. Regulation of high-voltage-activated Ca(2+) channel function, trafficking, and membrane stability by auxiliary subunits.

    Felix, Ricardo; Calderón-Rivera, Aida; Andrade, Arturo


    Voltage-gated Ca(2+) (CaV) channels mediate Ca(2+) ions influx into cells in response to depolarization of the plasma membrane. They are responsible for initiation of excitation-contraction and excitation-secretion coupling, and the Ca(2+) that enters cells through this pathway is also important in the regulation of protein phosphorylation, gene transcription, and many other intracellular events. Initial electrophysiological studies divided CaV channels into low-voltage-activated (LVA) and high-voltage-activated (HVA) channels. The HVA CaV channels were further subdivided into L, N, P/Q, and R-types which are oligomeric protein complexes composed of an ion-conducting CaVα1 subunit and auxiliary CaVα2δ, CaVβ, and CaVγ subunits. The functional consequences of the auxiliary subunits include altered functional and pharmacological properties of the channels as well as increased current densities. The latter observation suggests an important role of the auxiliary subunits in membrane trafficking of the CaVα1 subunit. This includes the mechanisms by which CaV channels are targeted to the plasma membrane and to appropriate regions within a given cell. Likewise, the auxiliary subunits seem to participate in the mechanisms that remove CaV channels from the plasma membrane for recycling and/or degradation. Diverse studies have provided important clues to the molecular mechanisms involved in the regulation of CaV channels by the auxiliary subunits, and the roles that these proteins could possibly play in channel targeting and membrane Stabilization.

  4. The voltage-gated proton channel Hv1 is expressed in pancreatic islet β-cells and regulates insulin secretion

    Zhao, Qing [Department of Biophysics, School of Physics Science, The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071 (China); Che, Yongzhe [School of Medicine, Nankai University, Tianjin 300071 (China); Li, Qiang; Zhang, Shangrong [Department of Biophysics, School of Physics Science, The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071 (China); Gao, Ying-Tang [Key Laboratory of Artificial Cell, Third Central Clinical College of Tianjin Medical University, Tianjin 300170 (China); Wang, Yifan; Wang, Xudong; Xi, Wang; Zuo, Weiyan [Department of Biophysics, School of Physics Science, The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071 (China); Li, Shu Jie, E-mail: [Department of Biophysics, School of Physics Science, The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071 (China)


    The voltage-gated proton channel Hv1 is a potent acid extruder that participates in the extrusion of the intracellular acid. Here, we showed for the first time, Hv1 is highly expressed in mouse and human pancreatic islet β-cells, as well as β-cell lines. Imaging studies demonstrated that Hv1 resides in insulin-containing granules in β-cells. Knockdown of Hv1 with RNA interference significantly reduces glucose- and K{sup +}-induced insulin secretion in isolated islets and INS-1 (832/13) β-cells and has an impairment on glucose- and K{sup +}-induced intracellular Ca{sup 2+} homeostasis. Our data demonstrated that the expression of Hv1 in pancreatic islet β-cells regulates insulin secretion through regulating Ca{sup 2+} homeostasis.

  5. Voltage/Pitch Control for Maximization and Regulation of Active/Reactive Powers in Wind Turbines with Uncertainties

    Guo, Yi; Jiang, John N; Tang, Choon Yik; Ramakumar, Rama G


    This paper addresses the problem of controlling a variable-speed wind turbine with a Doubly Fed Induction Generator (DFIG), modeled as an electromechanically-coupled nonlinear system with rotor voltages and blade pitch angle as its inputs, active and reactive powers as its outputs, and most of the aerodynamic and mechanical parameters as its uncertainties. Using a blend of linear and nonlinear control strategies (including feedback linearization, pole placement, uncertainty estimation, and gradient-based potential function minimization) as well as time-scale separation in the dynamics, we develop a controller that is capable of maximizing the active power in the Maximum Power Tracking (MPT) mode, regulating the active power in the Power Regulation (PR) mode, seamlessly switching between the two modes, and simultaneously adjusting the reactive power to achieve a desired power factor. The controller consists of four cascaded components, uses realistic feedback signals, and operates without knowledge of the C_p-...

  6. Development of cast resin multisecondary 1600kVA transformer for Regulated High Voltage Power Supply- A prototype

    Tripathi, V; Singh, N P; Gupta, L N; Oza, Kapil; Patel, Paresh; Baruah, U K [Institute for Plasma Research (IPR), Bhat, Gandhinagar 382428 (India)


    Regulated High Voltage Power Supplies (RHVPS) are commonly used in high-energy particle accelerators. RHVPS is a modular power supply in which kV level modules (40 or 80) are cascaded to generate desired level of voltage/power. One of the most challenging tasks involved is to provide input power to number of rectifier modules with required isolation (inter-winding and winding to ground). This is accomplished by deploying multi-secondary (large numbers, say 40 secondaries) transformers. This RHVPS concept was realized for the first time in the country with development of oil filled multi-secondary transformer. A pair of 3.3MVA, 11kV/ (940Vx40) has been successfully demonstrated, isolation of 6kVDC (inter-winding) and 160kVDC (all secondary to ground) tested. The next generation power supplies are unitized with indoor installations. This has created the demand for dry type multi-secondary transformers in compliance with safety regulations. This paper presents manufacturing issues and testing of the prototype resin cast coil. On the manufactured prototype, inter-winding isolation is tested up to 6kVDC and 125kVDC with respect to ground.

  7. Development of cast resin multisecondary 1600kVA transformer for Regulated High Voltage Power Supply- A prototype

    Tripathi, V.; Singh, N. P.; Gupta, L. N.; Oza, Kapil; Patel, Paresh; Baruah, U. K.


    Regulated High Voltage Power Supplies (RHVPS) are commonly used in high-energy particle accelerators. RHVPS is a modular power supply in which kV level modules (40 or 80#) are cascaded to generate desired level of voltage/power [1]. One of the most challenging tasks involved is to provide input power to number of rectifier modules with required isolation (inter-winding and winding to ground). This is accomplished by deploying multi-secondary (large numbers, say 40 secondaries) transformers. This RHVPS concept was realized for the first time in the country with development of oil filled multi-secondary transformer. A pair of 3.3MVA, 11kV/ (940Vx40) has been successfully demonstrated, isolation of 6kVDC (inter-winding) and 160kVDC (all secondary to ground) tested. The next generation power supplies are unitized with indoor installations. This has created the demand for dry type multi-secondary transformers in compliance with safety regulations. This paper presents manufacturing issues and testing of the prototype resin cast coil. On the manufactured prototype, inter-winding isolation is tested up to 6kVDC and 125kVDC with respect to ground.

  8. DC-Link Capacitor Voltage Regulation for Three-Phase Three-Level Inverter-Based Shunt Active Power Filter with Inverted Error Deviation Control

    Yap Hoon


    Full Text Available A new control technique known as inverted error deviation (IED control is incorporated into the main DC-link capacitor voltage regulation algorithm of a three-level neutral-point diode clamped (NPC inverter-based shunt active power filter (SAPF to enhance its performance in overall DC-link voltage regulation so as to improve its harmonics mitigation performances. In the SAPF controller, DC-link capacitor voltage regulation algorithms with either the proportional-integral (PI or fuzzy logic control (FLC technique have played a significant role in maintaining a constant DC-link voltage across the DC-link capacitors. However, both techniques are mostly operated based on a direct voltage error manipulation approach which is insufficient to address the severe DC-link voltage deviation that occurs during dynamic-state conditions. As a result, the conventional algorithms perform poorly with large overshoot, undershoot, and slow response time. Therefore, the IED control technique is proposed to precisely address the DC-link voltage deviation. To validate effectiveness and feasibility of the proposed algorithm, simulation work in MATLAB-Simulink and experimental implementation utilizing a TMS320F28335 Digital Signal Processor (DSP are performed. Moreover, conventional algorithms with PI and FLC techniques are tested too for comparison purposes. Both simulation and experimental results are presented, confirming the improvement achieved by the proposed algorithm in terms of accuracy and dynamic response in comparison to the conventional algorithms.

  9. Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P2.

    Yamaguchi, Shinji; Kurokawa, Tatsuki; Taira, Ikuko; Aoki, Naoya; Sakata, Souhei; Okamura, Yasushi; Homma, Koichi J


    Voltage-sensing phosphatase, VSP, consists of the transmembrane domain, operating as the voltage sensor, and the cytoplasmic domain with phosphoinositide-phosphatase activities. The voltage sensor tightly couples with the cytoplasmic phosphatase and membrane depolarization induces dephosphorylation of several species of phosphoinositides. VSP gene is conserved from urochordate to human. There are some diversities among VSP ortholog proteins; range of voltage of voltage sensor motions as well as substrate selectivity. In contrast with recent understandings of biophysical mechanisms of VSPs, little is known about its physiological roles. Here we report that chick ortholog of VSP (designated as Gg-VSP) induces morphological feature of cell process outgrowths with round cell body in DF-1 fibroblasts upon its forced expression. Expression of the voltage sensor mutant, Gg-VSPR153Q with shifted voltage dependence to a lower voltage led to more frequent changes of cell morphology than the wild-type protein. Coexpression of PTEN that dephosphorylates PI(3,4)P2 suppressed this effect by Gg-VSP, indicating that the increase of PI(3,4)P2 leads to changes of cell shape. In addition, visualization of PI(3,4)P2 with the fluorescent protein fused with the TAPP1-derived pleckstrin homology (PH) domain suggested that Gg-VSP influenced the distribution of PI(3,4)P2 . These findings raise a possibility that one of the VSP's functions could be to regulate cell morphology through voltage-sensitive tuning of phosphoinositide profile.

  10. Regulation of L-type Voltage Gated Calcium Channel CACNA1S in Macrophages upon Mycobacterium tuberculosis Infection.

    Antony, Cecil; Mehto, Subhash; Tiwari, Brijendra K; Singh, Yogendra; Natarajan, Krishnamurthy


    We demonstrated earlier the inhibitory role played by Voltage Gated Calcium Channels (VGCCs) in regulating Mycobacterium tuberculosis (M. tb) survival and pathogenesis. In this report, we investigated mechanisms and key players that regulate the surface expression of VGCC-CACNA1S by Rv2463 and M. tb infection in macrophages. Our earlier work identified Rv2463 to be expressed at early times post infection in macrophages that induced suppressor responses to dendritic cells and macrophages. Our results in this study demonstrate a role of MyD88 independent TLR pathway in mediating CACNA1S expression. Dissecting the role for second messengers, we show that calcium homeostasis plays a key role in CACNA1S expression during M. tb infection. Using siRNAs against molecular sensors of calcium regulation, we show an involvement of ER associated Stromal Interaction Molecules 1 and 2 (STIM1 and STIM2), and transcription factor pCREB, towards CACNA1S expression that also involved the MyD88 independent pathway. Interestingly, reactive oxygen species played a negative role in M. tb mediated CACNA1S expression. Further, a cross-regulation of ROS and pCREB was noted that governed CACNA1S expression. Characterizing the mechanisms governing CACNA1S expression would improve our understanding of the regulation of VGCC expression and its role in M. tb pathogenesis during M. tb infection.

  11. Global analysis of a buck regulator. [for voltage using discrete control law

    Edwards, D. B.; Caughey, T. K.


    Sufficient conditions for global stability of a buck regulator using a discrete control law are found. The method of paired systems and Liapunov functions are used to establish global stability and to study the convergence of the regulator. A heuristic argument is given that the optimal switching curves associated with the paired continuous systems approximate the optimal switching curves of the discrete systems.

  12. A Capacitor-Free, Fast Transient Response Linear Voltage Regulator In a 180nm CMOS

    Deleuran, Alexander N.; Lindbjerg, Nicklas; Pedersen, Martin K.;


    A 1.8 V capacitor-free linear regulator with fast transient response based on a new topology with a fast and slow regulation loop is presented. The design has been laid out and simulated in a 0.18 µm CMOS process. The design has a low component count and is tailored for system-on-chip integration...

  13. [Role of calcineurin in down-regulation of left ventricular transmural voltage- dependent K(+) currents in mice with heart failure].

    Shi, Chen-Xia; Dong, Fang; Chang, Yan-Chao; Wang, Xiao-Feng; Xu, Yan-Fang


    The aim of the present study was to investigate the role of calcineurin in the down-regulation of left ventricular transmural voltage-dependent K(+) currents in heart failure. Transverse aorta was banded by using microsurgical techniques to create mouse heart failure model. Sham-operated (Sham) or aorta banded (Band) mice were randomized to receive calcineurin inhibitor cyclosporine A (CsA) or vehicle. The densities and kinetic properties of voltage-dependent K(+) currents, as well as action potential (AP), of left ventricular subendocardial (Endo) and subepicardial (Epi) myocytes were determined by using whole-cell patch-clamp technique. The results showed that calcineurin activity was significant higher in Endo myocytes than that in Epi ones in all the groups. Compared with Sham group, Band mice showed significantly increased calcineurin activity both in Endo and Epi myocytes. CsA significantly reduced calcineurin activity in Band mice. CsA treatment in Band mice partially reversed the down-regulation of Ito density, completely reversed the down-regulation of IK,slow density both in Endo and Epi myocytes, and Iss density in Endo myocytes. In addition, CsA treatment in Band mice partially antagonized the prolongation of action potential duration (APD), and APD at 50% (APD50) and 90% repolarization (APD90) were significantly reduced. Because of non-parallel shortening of APD in Endo and Epi myocytes, the ratio of Endo/Epi APD90 was reduced from 4.8:1 in Band mice to 2.6:1 in CsA-treated mice, which was close to that in Sham mice. The results suggest that non-parallel activation of calcineurin in Endo and Epi myocytes contributes to the down-regulation of transmural voltage-dependent K(+) currents and the amplification of transmural dispersion of repolarization (TDR) in left ventricular failure hearts. Inhibition of calcineurin may be a potential new therapeutic strategy to prevent and cure arrhythmias and sudden death in heart failure.

  14. Steroid hormone regulation of the voltage-gated, calcium-activated potassium channel expression in developing muscular and neural systems.

    Garrison, Sheldon L; Witten, Jane L


    A precise organization of gene expression is required for developing neural and muscular systems. Steroid hormones can control the expression of genes that are critical for development. In this study we test the hypothesis that the steroid hormone ecdysone regulates gene expression of the voltage-gated calcium-activated potassium ion channel, Slowpoke or KCNMA1. Late in adult development of the tobacco hawkmoth Manduca sexta, slowpoke (msslo) levels increased contributing to the maturation of the dorsal longitudinal flight muscles (DLMs) and CNS. We show that critical components of ecdysteroid gene regulation were present during upreglation of msslo in late adult DLM and CNS development. Ecdysteroid receptor complex heterodimeric partner proteins, the ecdysteroid receptor (EcR) and ultraspiracle (USP), and the ecdysone-induced early gene, msE75B, were expressed at key developmental time points, suggesting that ecdysteroids direct aspects of gene expression in the DLMs during these late developmental stages. We provide evidence that ecdysteroids suppress msslo transcription in the DLMs; when titers decline msslo transcript levels increase. These results are consistent with msslo being a downstream gene in an ecdysteroid-mediated gene cascade during DLM development. We also show that the ecdysteroids regulate msslo transcript levels in the developing CNS. These results will contribute to our understanding of how the spatiotemporal regulation of slowpoke transcription contributes to tailoring cell excitability to the differing physiological and behavioral demands during development.

  15. 电炉变压器的一种崭新调压方式--移相调压%A Brand-new Voltage Regulation Method-Phase Shift Voltage Regulation of the Furnace Transformer



    阐述了该崭调压方式变压器的移相调压原理,指明新型调压方式变压器与传通变压器区别仅在于变压器一次线圈,介绍了该型变压器运行和制造特点事项。%This paper approaches the phase shift principle of transformers with a new voltage regulating mode, indicates the only difference between the new type of transformers and conventional transformers is that the new type of transformers comprises a primary coil and introduces the characteristics of its operation and its manufacturing issues.

  16. Discrete-Time Domain Modelling of Voltage Source Inverters in Standalone Applications: Enhancement of Regulators Performance by Means of Smith Predictor

    Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Freijedo Fernandez, Francisco Daniel


    and Smith predictor design, respectively, are obtained. Subsequently, the voltage regulator is also designed for a wide bandwidth, which permits the inclusion of resonant filters for the steady-state mitigation of odd harmonics at nonlinear unbalance load terminals. Discrete-time domain implementation......The decoupling of the capacitor voltage and inductor current has been shown to improve significantly the dynamic performance of voltage source inverters in standalone applications. However, the computation and PWM delays still limit the achievable bandwidth. In this paper a discrete-time domain...

  17. Analysis and simulation of the three-phase AC voltage regulation circuit%三相交流调压电路的分析与仿真



    Based on the analysis of the operation principle and mode of the single-phase AC voltage-regulation circuit, the voltage-regulating rule and effect of three-phase AC voltage-regulation was studied deeply in the paper. The theory of the three-phase star-style AC voltage-regulation circuit was tested in matlab/simulink, the simulation result proved the analysis of the theory of the three-phase AC voltage-regulation circuit was correct.%在分析单相交流调压电路运行原理和工作方式的基础上,深入研究了三相交流调压电路的调压规律和调压效果,并在Matlab/simulink仿真平台上对三相星形无中线交流调压电路的理论部分进行了验证,结果表明:三相交流调压电路的分析是正确的.

  18. Voltage-gated K+ currents in mouse articular chondrocytes regulate membrane potential.

    Clark, Robert B; Hatano, Noriyuki; Kondo, Colleen; Belke, Darrell D; Brown, Barry S; Kumar, Sanjay; Votta, Bartholomew J; Giles, Wayne R


    Membrane currents and resting potential of isolated primary mouse articular chondrocytes maintained in monolayer cell culture for 1-9 days were recorded using patch clamp methods. Quantitative RT-PCR showed that the most abundantly expressed transcript of voltage-gated K(+) channels was for K(V)1.6, and immunological methods confirmed the expression of K(V)1.6 α-subunit proteins. These chondrocytes expressed a large time- and potential-dependent, Ca(2+)-independent 'delayed rectifier' K(+) current. Steady-state activation was well-fit by a Boltzmann function with a threshold near -50 mV, and a half-activation potential of -34.5 mV. The current was 50% blocked by 1.48 mM tetraethylammonium, 0.66 mM 4-aminopyridine and 20.6 nM α-dendrotoxin. The current inactivated very slowly at membrane potentials in the range of the resting potential of the chondrocytes. Resting membrane potential of the chondrocytes at room temperature (19-21°C) and in 5 mM external K(+) was -46.4 ± 1.3 mV (mean ± s.e.m; n = 23), near the 'foot' of the activation curve of this K(+) current. Resting potential was depolarized by an average of 4.2 ± 0.8 mV by 25 mM TEA, which blocked about 95% of the K(+) current. At a membrane potential of -50 mV, the apparent time constant of inactivation (tau(in)) was 37.9 s, and the 'steady-state' current level was 19% of that at a holding potential of -90 mV; at -40 mV, tau(in) was 20.3 s, and 'steady-state' current was 5% of that at -90 mV. These results demonstrate that in these primary cultured, mouse articular chondrocytes steady-state activation of a voltage-gated K(+) current contributes to resting membrane potential. However, this current is also likely to have a significant physiological role in repolarizing the chondrocyte following depolarizing stimuli that might occur in conditions of membrane stretch. For example, activation of TRP('transient receptor potential') non-specific cation channels in these cells during cyclic loading and unloading

  19. Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability.

    Cooper, E C; Tomiko, S A; Agnew, W S


    At equilibrium, voltage-sensitive sodium channels normally are closed at all potentials. They open transiently in response to changes in membrane voltage or chronically under the influence of certain neurotoxins. Covalent modifications that result in chronic opening may help identify molecular domains involved in conductance regulation. Here, the purified sodium channel from electric eel electroplax, reconstituted in artificial liposomes, has been used to screen for such modifications. When the liposomes were treated with the alkaloid neurotoxin batrachotoxin, sodium-selective ion fluxes were produced, with permeability ratios PNa greater than PTl greater than PK greater than PRb greater than PCs. When the liposomes were treated with either of two oxidizing reagents (N-bromoacetamide or N-bromosuccinimide), or with Pronase or trypsin, ion-selective fluxes also were stimulated. These were blocked by tetrodotoxin and the anesthetic QX-314 in a manner suggesting that only modification of the cytoplasmic protein surface resulted in stimulation. Limited exposure to trypsin resulted in strong flux activation, with the concomitant appearance of peptide fragments with masses of approximately equal to 130, 70, and 38 kDa and fragments with masses of 45 and 24 kDa appearing later. We propose that characterization of these fragments may allow identification of channel domains important for inactivation gating. Images PMID:2442755

  20. Diverse roles for auxiliary subunits in phosphorylation-dependent regulation of mammalian brain voltage-gated potassium channels.

    Vacher, Helene; Trimmer, James S


    Voltage-gated ion channels are a diverse family of signaling proteins that mediate rapid electrical signaling events. Among these, voltage-gated potassium or Kv channels are the most diverse partly due to the large number of principal (or α) subunits and auxiliary subunits that can assemble in different combinations to generate Kv channel complexes with distinct structures and functions. The diversity of Kv channels underlies much of the variability in the active properties between different mammalian central neurons and the dynamic changes that lead to experience-dependent plasticity in intrinsic excitability. Recent studies have revealed that Kv channel α subunits and auxiliary subunits are extensively phosphorylated, contributing to additional structural and functional diversity. Here, we highlight recent studies that show that auxiliary subunits exert some of their profound effects on dendritic Kv4 and axonal Kv1 channels through phosphorylation-dependent mechanisms, either due to phosphorylation on the auxiliary subunit itself or by influencing the extent and/or impact of α subunit phosphorylation. The complex effects of auxiliary subunits and phosphorylation provide a potent mechanism to generate additional diversity in the structure and function of Kv4 and Kv1 channels, as well as allowing for dynamic reversible regulation of these important ion channels.

  1. Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function

    Antollini, Silvia S.; Barrantes, Francisco J.


    Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action. PMID:27965583

  2. Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function.

    Antollini, Silvia S; Barrantes, Francisco J


    Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action.

  3. An internal model approach to (optimal) frequency regulation in power grids with time-varying voltages

    Trip, Sebastian; Buerger, Mathias; De Persis, Claudio


    This paper studies the problem of frequency regulation in power grids under unknown and possible time-varying load changes, while minimizing the generation costs. We formulate this problem as an output agreement problem for distribution networks and address it using incremental passivity and distrib

  4. Distributed Nonlinear Control with Event-Triggered Communication to Achieve Current-Sharing and Voltage Regulation in DC Microgrids

    Han, Renke; Meng, Lexuan; Guerrero, Josep M.


    A distributed nonlinear controller is presented to achieve both accurate current-sharing and voltage regulation simultaneously in dc microgrids considering different line impedances’ effects among converters. Then, an improved event-triggered principle for the controller is introduced through...... combining the state-dependent tolerance with a nonnegative offset. In order to design the event-triggered principle and guarantee the global stability, a generalized dc microgrid model is proposed and proven to be positive definite, based on which Lyapunov-based approach is applied. Furthermore, considering...... the effects from constant power loads, the damping performance of proposed controller is further improved and compared with the traditional V-I droop controller. The proposed event-triggered-based communication strategy can considerably reduce the communication traffic and significantly relax the requirement...

  5. Current regulators for I/SUP 2/L circuits to be operated from low-voltage power supplies

    Bruun, Erik; Hansen, Ole


    A new bandgap current reference is described which can be used to control the injector current of I/SUP 2/L circuits for supply voltages down to about 1 V. For small currents the total injector current is obtained as a mirror of the reference current. For large injector currents the current control...... is performed by a series regulator which compares the injector current of one I/SUP 2/L gate to the reference current. The described reference current can be adjusted to give a variation with temperature of about 60 ppm/°C over the temperature range -10 to +70°C. However, in some applications a nonzero......, but well controlled temperature coefficient is desired. It is shown how a temperature stable ring oscillator with I/SUP 2/L gates can be constructed by tailoring the temperature dependence of the supply current appropriately....

  6. Actin Dynamics Regulates Voltage-Dependent Calcium-Permeable Channels of the Vicia faba Guard Cell Plasma Membrane

    Wei Zhang; Liu-Min Fan


    Free cytosolic Ca~(2+) ([Ca~(2+)]_(cyt)) is an ubiquitous second messenger in plant cell signaling, and [Ca~(2+)]_(cyt) elevation is associated with Ca~(2+)-permeable channels in the plasma membrane and endomembranes regulated by a wide range of stimuli. However, knowledge regarding Ca~(2+) channels and their regulation remains limited in planta. A type of voltage-dependent Ca~(2+)-permeable channel was identified and characterized for the Vicia faba L. guard cell plasma membrane by using patch-clamp techniques. These channels are permeable to both Ba~(2+) and Ca~(2+), and their activities can be inhibited by micromolar Gd~(3+). The unitary conductance and the reversal potential of the channels depend on the Ca~(2+) or Ba~(2+) gradients across the plasma membrane. The inward whole-cell Ca~(2+) (Ba~(2+)) current, as well as the unitary current amplitude and NP. of the single Ca~(2+) channel, increase along with the membrane hyperpolarization. Pharmacological experiments suggest that actin dynamics may serve as an upstream regulator of this type of calcium channel of the guard cell plasma membrane. Cytochalasin D, an actin polymerization blocker, activated the NP_o of these channels at the single channel level and increased the current amplitude at the whole-cell level. But these channel activations and current increments could be restrained by pretreatment with an F-actin stabilizer, phalloidin. The potential physiological significance of this regulatory mechanism is also discussed.

  7. Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells

    Tiran, Zohar; Peretz, Asher; Sines, Tal


    Tyrosine phosphatases (PTPs) epsilon and alpha are closely related and share several molecular functions, such as regulation of Src family kinases and voltage-gated potassium (Kv) channels. Functional interrelationships between PTPepsilon and PTPalpha and the mechanisms by which they regulate K...... but are not fully redundant. We conclude that PTPepsilon and PTPalpha differ significantly in their regulation of Kv channels and Src in the system examined and that similarity between PTPs does not necessarily result in full functional redundancy in vivo....

  8. Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation.

    Ronjat, Michel; Kiyonaka, Shigeki; Barbado, Maud; De Waard, Michel; Mori, Yasuo


    The pore-forming subunit of voltage-gated calcium channels is associated to auxiliary subunits among which the cytoplasmic β subunit. The different isoforms of this subunit control both the plasma membrane targeting and the biophysical properties of the channel moiety. In a recent study, we demonstrated that the Cacnb4 (β 4) isoform is at the center of a new signaling pathway that connects neuronal excitability and gene transcription. This mechanism relies on nuclear targeting of β 4 triggered by neuronal electrical stimulation. This re-localization of β 4 is promoted by its interaction with Ppp2r5d a regulatory subunit of PP2A in complex with PP2A itself. The formation, as well as the nuclear translocation, of the β 4/ Ppp2r5d/ PP2A complex is totally impaired by the premature R482X stops mutation of β 4 that has been previously associated with juvenile epilepsy. Taking as a case study the tyrosine hydroxylase gene that is strongly upregulated in brain of lethargic mice, deficient for β 4 expression, we deciphered the molecular steps presiding to this signaling pathway. Here we show that expression of wild-type β 4 in HEK293 cells results in the regulation of several genes, while expression of the mutated β 4 (β 1-481) produces a different set of gene regulation. Several genes regulated by β 4 in HEK293 cells were also regulated upon neuronal differentiation of NG108-15 cells that induces nuclear translocation of β 4 suggesting a link between β 4 nuclear targeting and gene regulation.

  9. Single-Event Transient Testing of Low Dropout PNP Series Linear Voltage Regulators

    Adell, Philippe; Allen, Gregory


    As demand for high-speed, on-board, digital-processing integrated circuits on spacecraft increases (field-programmable gate arrays and digital signal processors in particular), the need for the next generation point-of-load (POL) regulator becomes a prominent design issue. Shrinking process nodes have resulted in core rails dropping to values close to 1.0 V, drastically reducing margin to standard switching converters or regulators that power digital ICs. The goal of this task is to perform SET characterization of several commercial POL converters, and provide a discussion of the impact of these results to state-of-the-art digital processing IC through laser and heavy ion testing

  10. GAPOD and GA DC-voltage regulator based UPFC supplementary cont roller for damping low frequency oscillations in Multi-machine power systems

    Dakka. Obulesu, Dr. S.F. Kodad, Dr. B.V. Sankar Ram


    Full Text Available The Unified Power Flow Controller (UPFC is the most versatile device in the FACTS (Flexible AC Transmission Systems which has emerged to enhance power system stability spectrum and dynamic performance. This paper briefs the effectiveness of the proposed GAPOD and GA DC-voltage regulator which has been tested on a 3-Machine, 9-Bus power system in comparison with Particle swarm optimization based Multi-Stage Fuzzy (PSOMSF DC-voltage regulator. The non-linear time-domain simulation results show thatthe oscillations of synchronous machines could be quickly and effectively damped with proposed GAPOD and GA DC-voltage regulator. The construction and implementation of this controller is fairly easy, which can be useful in real world power system.

  11. SEMICONDUCTOR INTEGRATED CIRCUITS: A current-mode voltage regulator with an embedded sub-threshold reference for a passive UHF RFID transponder

    Zhongqi, Liu; Chun, Zhang; Yongming, Li; Zhihua, Wang


    This paper presents a current-mode voltage regulator for a passive UHF RFID transponder. The passive tag power is extracted from RF energy through the RF-to-DC rectifier. Due to huge variations of the incoming RF power, the rectifier output voltage should be regulated to achieve a stable power supply. By accurately controlling the current flowing into the load with an embedded sub-threshold reference, the regulated voltage varies in a range of 1-1.3 V from -20 to 80 °C, and a bandwidth of about 100 kHz is achieved for a fast power recovery. The circuit is fabricated in UMC 0.18 μm mixed-mode CMOS technology, and the current consumption is only 1 μA.

  12. Discussion on Voltage Regulation Scheme of Power Plant System%关于发电厂系统电压调节方案的探讨



    Take the voltage regulation of a power plant as the example, how to regulate the system voltage of power plant when the transfer index unchanged was analyzed. The three schemes of system voltage regulation of power plant were discussed, and got the Scheme No.3 was more suitable for the power plant.%文章以某厂的电压调节为例,分析如何在不变更调差系数的前提下调节发电厂系统电压值,对发电厂系统电压调节的三个可能性方案进行探讨,得出方案三最适合某厂实际情况。

  13. Fully Integrated, Low Drop-Out Linear Voltage Regulator in 180 nm CMOS

    Yosef-Hay, Yoni; Larsen, Dennis Øland; Llimos Muntal, Pere


    . The proposed design works without the need of a decoupling capacitor connected at the output and operates with a 0-100 pF capacitive load. The design has been taped out in a 0.18 µm CMOS process. The proposed regulator has a low component count, area of 0.012 mm2 and is suitable for system-on-chip integration...

  14. Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2.

    Bongiorno, Daria; Schuetz, Friderike; Poronnik, Philip; Adams, David J


    The electrical excitability of neurons is mediated primarily by voltage-gated ion channels, particularly voltage-gated Na(+) (Na(v)), K(+) (K(v)) and Cl(-) (ClC) channels. Cells regulate their electrical excitability by controlling not only the activity, but also the number of individual ion channels in the plasma membrane. There exist several mechanisms for regulating levels of voltage-gated ion channels: transcription and translation, retention and export from the endoplasmic reticulum as well as insertion and retrieval from the plasma membrane. Alterations in voltage-gated ion channel activity, composition and distribution can contribute to the pathophysiology of epilepsy, hypertension, neuropathic and inflammatory pain. One mechanism for retrieval is ubiquitination. Here specific ubiquitin ligases bind to membrane proteins to modulate and regulate their cellular fate. In this review, we focus on Nedd4 and Nedd4-2 ubiquitin ligases and the mechanisms by which they regulate voltage-gated ion channels and describe a novel paradigm on the mechanisms that underpin aberrant ion channel function in neurological disorders.

  15. Study on automatic voltage regulation technology of rural power grids%农村电网自动稳压技术的研究

    孙猛; 赵玉林; 付岩


    经技术改造,农网电压质量有所提高,但波动范围仍然超出国家规定允许值,制约农村经济的发展.文章研究一种基于固态继电器的采用对农网配变电压器调压绕组正反串联,实现稳定农村电网电压目的的无触点有栽调压分接开关的接线及其控制方式.理论分析与模拟实验表明,这种稳压技术具有调压范围大,元件实际承受电压低,结构简单的优点,适用于农村电网.%Through technical reconstruction, the rural power grid voltage quality has been improved. But the voltage fluctuation range is still lager than the allowable value of national regulation. This situation seriously restricts the development of rural economy. This paper studied a non-contact on-load voltage regulation tap changer wiring and its control method. Used the way of connecting the regulating windings of distribution transformer positive and negative to achieve the goal of stabilizing the voltage of rural power grids. Theory analysis and simulation experiment manifested that this stabilizing voltage technology had advantages of large voltage regulating range, low actual beard voltage of elements and simple structure. And this technology was suitable for rural power grid.

  16. Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts.

    Kotake, Shigeru; Yago, Toru; Kawamoto, Manabu; Nanke, Yuki


    Fewer molecules have been identified on human than murine osteoclasts, the former differing from murine osteoclasts in many ways. We show that voltage-dependent anion channels (VDACs, porin) are expressed in the plasma membrane of human osteoclasts. A search for novel proteins expressed in the plasma membrane of human osteoclasts identified VDAC. Anti-VDAC antibodies inhibited human osteoclastogenesis in vitro. VDAC expression was detected in membranes by immunoelectron microscopy and immunocytochemical double staining. The VDAC protein functions as a Cl(-) channel. VDACs regulate bone resorption, which show using Osteologic™ plates. The epitope of the antibody lay within a 10-amino acid sequence in the VDAC. The findings suggest that the VDAC is, at least partly, a novel Cl(-) channel regulating the differentiation and function of human osteoclasts. VDACs may play a crucial role in acidifying the resorption lacunae between osteoclasts and bone. Inhibitors of VDACs could be used to treat diseases involving increased resorption, such as osteoporosis, rheumatoid arthritis, and Paget's disease. © 2012 International Federation for Cell Biology.

  17. S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation.

    Groome, James R; Winston, Vern


    The movement of positively charged S4 segments through the electric field drives the voltage-dependent gating of ion channels. Studies of prokaryotic sodium channels provide a mechanistic view of activation facilitated by electrostatic interactions of negatively charged residues in S1 and S2 segments, with positive counterparts in the S4 segment. In mammalian sodium channels, S4 segments promote domain-specific functions that include activation and several forms of inactivation. We tested the idea that S1-S3 countercharges regulate eukaryotic sodium channel functions, including fast inactivation. Using structural data provided by bacterial channels, we constructed homology models of the S1-S4 voltage sensor module (VSM) for each domain of the mammalian skeletal muscle sodium channel hNaV1.4. These show that side chains of putative countercharges in hNaV1.4 are oriented toward the positive charge complement of S4. We used mutagenesis to define the roles of conserved residues in the extracellular negative charge cluster (ENC), hydrophobic charge region (HCR), and intracellular negative charge cluster (INC). Activation was inhibited with charge-reversing VSM mutations in domains I-III. Charge reversal of ENC residues in domains III (E1051R, D1069K) and IV (E1373K, N1389K) destabilized fast inactivation by decreasing its probability, slowing entry, and accelerating recovery. Several INC mutations increased inactivation from closed states and slowed recovery. Our results extend the functional characterization of VSM countercharges to fast inactivation, and support the premise that these residues play a critical role in domain-specific gating transitions for a mammalian sodium channel.

  18. 有载调压分接开关运行与异常状态分析%Operation and the Abnormal State of Load Voltage Regulation Tap



    本文介绍了CV型有载调压分接开关的动作原理、电压变化过程,对有载调压分接开关异常情况进行了汇总分析,强调了加强状态检修与维护的要点,并提出了一些有价值的建议.%This paper introduces the action principle of CV-type load voltage regulation tap, the change process of voltage, summarizes the abnormal situations of load voltage regulation tap, emphasizes the main points of the state repair and maintenance, and made some valuable suggestions.

  19. 一种微机电源的LDO设计与实现%Design and implementation of low dropout linear voltage regulator for the microcomputer power supply

    胡玫; 王永喜; 刘保录


    针对微机电源稳压性能较差的缺点,设计一款输出电压为5 V,最大输出电流为1 A的低压差线性稳压器( LDO)。通过选择误差放大器、反馈电阻网络、大功率N沟道MOS管作为调整管;采用具有过温、限流保护功能的芯片和外围电路构成基准源电路,改善了稳压器的线性调整率。测试结果表明,室温下输入电压为5.5~25 V时,输出电压稳定在5 V,负载为5Ω时电压调整率为0.6%,显示出良好的稳压性能。%A low dropout linear regulator ( LDO) is designed with maximal output current of 1 A and 5 V output voltage for the microcomputer voltage regulation performance is poorer. The error amplifier, feedback resistance network, NMOS adjustment transistor are selected. Meanwhile the peripheral circuit and the chip which integrates the thermal and the current protect circuit make up the reference source to improve the performance of linear adjustment ratio. The test results show that when the input voltage of 5. 5 ~ 25 V at room temperature, the output voltage is 5 V. The voltage regulation rate was 0. 6% under 5 Ω load, which the voltage regulation performance is good.

  20. A High-Voltage class-D power amplifier with switching frequency regulation for improved high-efficiency output power range

    Ma, Haifeng; Zee, van der Ronan; Nauta, Bram


    This paper describes the power dissipation analysis and the design of an efficiency-improved high-voltage class-D power amplifier. The amplifier adaptively regulates its switching frequency for optimal power efficiency across the full output power range. This is based on detecting the switching outp

  1. mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways

    Farr Niere


    Full Text Available The mammalian/mechanistic target of rapamycin complex 1 (mTORC1 serves as a regulator of mRNA translation. Recent studies suggest that mTORC1 may also serve as a local, voltage sensor in the postsynaptic region of neurons. Considering biochemical, bioinformatics and imaging data, we hypothesize that the activity state of mTORC1 dynamically regulates local membrane potential by promoting and repressing protein synthesis of select mRNAs. Our hypothesis suggests that mTORC1 uses positive and negative feedback pathways, in a branch-specific manner, to maintain neuronal excitability within an optimal range. In some dendritic branches, mTORC1 activity oscillates between the “On” and “Off” states. We define this as negative feedback. In contrast, positive feedback is defined as the pathway that leads to a prolonged depolarized or hyperpolarized resting membrane potential, whereby mTORC1 activity is constitutively on or off, respectively. We propose that inactivation of mTORC1 increases the expression of voltage-gated potassium alpha (Kv1.1 and 1.2 and beta (Kvβ2 subunits, ensuring that the membrane resets to its resting membrane potential after experiencing increased synaptic activity. In turn, reduced mTORC1 activity increases the protein expression of syntaxin-1A and promotes the surface expression of the ionotropic glutamate receptor N-methyl-D-aspartate (NMDA-type subunit 1 (GluN1 that facilitates increased calcium entry to turn mTORC1 back on. Under conditions such as learning and memory, mTORC1 activity is required to be high for longer periods of time. Thus, the arm of the pathway that promotes syntaxin-1A and Kv1 protein synthesis will be repressed. Moreover, dendritic branches that have low mTORC1 activity with increased Kv expression would balance dendrites with constitutively high mTORC1 activity, allowing for the neuron to maintain its overall activity level within an ideal operating range. Finally, such a model suggests that

  2. Derivation of linearized transfer functions for switching-mode regulations. Phase A: Current step-up and voltage step-up converters

    Wong, R. C.; Owen, H. A., Jr.; Wilson, T. G.


    Small-signal models are derived for the power stage of the voltage step-up (boost) and the current step-up (buck) converters. The modeling covers operation in both the continuous-mmf mode and the discontinuous-mmf mode. The power stage in the regulated current step-up converter on board the Dynamics Explorer Satellite is used as an example to illustrate the procedures in obtaining the small-signal functions characterizing a regulated converter.

  3. 内燃机车励磁恒压调节装置电路设计%Circuit design of excitation and constant voltage regulator for diesel locomotive



    介绍内燃机车励磁恒压调节装置的功能,详细叙述了该装置的过压、欠压和过流保护电路原理,阐述了利用脉宽调制来控制输出的电压值和电流值的方法。TPZ25型恒压励磁调节装置现已运用在160km/h“曙光号”内燃动车上,在国内内燃机车供电系统属首次研制。%Functions of the excitation and constant voltage regulator fordiesel locomotive are introduced, of which the circuit principle of over-voltage, under-voltage and over-current protection is depicted. Also expounded is the voltage and current control method via pulse width modulation (PWM). Currently TPZ25 excitation and constant voltage regulator has been installed on 160 km/h “Shu Guang Hao” DMU.

  4. Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.

    Tang, Min; Wu, Guanyi; Wang, Zhongli; Yang, Niuniu; Shi, Hao; He, Qian; Zhu, Chan; Yang, Yan; Yu, Guang; Wang, Changming; Yuan, Xiaolin; Liu, Qin; Guan, Yun; Dong, Xinzhong; Tang, Zongxiang


    Itch is described as an unpleasant or irritating skin sensation that elicits the desire or reflex to scratch. MrgprA3, one of members of the Mrgprs family, is specifically expressed in a subpopulation of dorsal root ganglion (DRG) in the peripheral nervous system (PNS). These MrgprA3-expressing DRG neurons have been identified as itch-specific neurons. They can be activated by the compound, chloroquine, which is used as a drug to treat malaria. In the present study, we labeled these itch-specific neurons using the method of molecular genetic markers, and then studied their electrophysiological properties. We also recorded the cutaneous MrgprA3(-) neurons retrogradely labeled by Dil dye (MrgprA3(-)-Dil). We first found that MrgprA3(+) neurons have a lower excitability than MrgprA3(-) neurons (MrgprA3(-)-non-Dil and MrgprA3(-)-Dil). The number of action potential (AP) was reduced more obviously in MrgprA3(+) neurons than that of in MrgprA3(-) neurons. In most cases, MrgprA3(+) neurons only generated single AP; however, in MrgprA3(-) neurons, the same stimulation could induce multiple AP firing due to the greater voltage-gated potassium (Kv) current existence in MrgprA3(+) than in MrgprA3(-) neurons. Thus, Kv current plays an important role in the regulation of excitability in itch-specific neurons.

  5. Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.

    Kawai, Takafumi; Okochi, Yoshifumi; Ozaki, Tomohiko; Imura, Yoshio; Koizumi, Schuichi; Yamazaki, Maya; Abe, Manabu; Sakimura, Kenji; Yamashita, Toshihide; Okamura, Yasushi


    It has been established that voltage-gated proton channels (VSOP/Hv1), encoded by Hvcn1, support reactive oxygen species (ROS) production in phagocytic activities of neutrophils (El Chemaly et al. ) and antibody production in B lymphocytes (Capasso et al. ). VSOP/Hv1 is a potential therapeutic target for brain ischemia, since Hvcn1 deficiency reduces microglial ROS production and protects brain from neuronal damage (Wu et al. ). In the present study, we report that VSOP/Hv1 has paradoxical suppressive role in ROS production in microglia. Extracellular ROS production was lower in neutrophils of Hvcn1(-/-) mice than WT mice as reported. In contrast, it was drastically enhanced in isolated Hvcn1(-/-) microglia as compared with cells from WT mice. Actin dynamics was altered in Hvcn1(-/-) microglia and intracellular distribution of cytosolic NADPH oxidase subunit, p67, was changed. When expression levels of oxidative stress responsive antioxidant genes were compared between WT and Hvcn1(-/-) in cerebral cortex at different ages of animals, they were slightly decreased in Hvcn1(-/-) mice at younger stage (1 day, 5 days, 3 weeks old), but drastically increased at aged stage (6 months old), suggesting that the regulation of microglial ROS production by VSOP/Hv1 is age-dependent. We also performed brain ischemic stroke experiments and found that the neuroprotective effect of VSOP/Hv1deficiency on infarct volume depended on the age of animals. Taken together, regulation of ROS production by VSOP/Hv1 is more complex than previously thought and significance of VSOP/Hv1 in microglial ROS production depends on age. © 2017 International Society for Neurochemistry.

  6. Seeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels.

    Van Petegem, Filip; Lobo, Paolo A; Ahern, Christopher A


    Voltage-gated sodium channels (Na(V)s) underlie the upstroke of the action potential in the excitable tissues of nerve and muscle. After opening, Na(V)s rapidly undergo inactivation, a crucial process through which sodium conductance is negatively regulated. Disruption of inactivation by inherited mutations is an established cause of lethal cardiac arrhythmia, epilepsy, or painful syndromes. Intracellular calcium ions (Ca(2+)) modulate sodium channel inactivation, and multiple players have been suggested in this process, including the cytoplasmic Na(V) C-terminal region including two EF-hands and an IQ motif, the Na(V) domain III-IV linker, and calmodulin. Calmodulin can bind to the IQ domain in both Ca(2+)-bound and Ca(2+)-free conditions, but only to the DIII-IV linker in a Ca(2+)-loaded state. The mechanism of Ca(2+) regulation, and its composite effect(s) on channel gating, has been shrouded in much controversy owing to numerous apparent experimental inconsistencies. Herein, we attempt to summarize these disparate data and propose a novel, to our knowledge, physiological mechanism whereby calcium ions promote sodium current facilitation due to Ca(2+) memory at high-action-potential frequencies where Ca(2+) levels may accumulate. The available data suggest that this phenomenon may be disrupted in diseases where cytoplasmic calcium ion levels are chronically high and where targeted phosphorylation may decouple the Ca(2+) regulatory machinery. Many Na(V) disease mutations associated with electrical dysfunction are located in the Ca(2+)-sensing machinery and misregulation of Ca(2+)-dependent channel modulation is likely to contribute to disease phenotypes.

  7. A Low-Power Voltage Limiter/Regulator IC in Standard Thick-Oxide 130 nm CMOS for Inductive Power Transfer Application

    Stepan Lapshev


    Full Text Available This paper presents a novel CMOS low-power voltage limiter/regulator circuit with hysteresis for inductive power transfer in an implanted telemetry application. The circuit controls its rail voltage to the maximum value of 3 V DC employing 100 mV of comparator hysteresis. It occupies a silicon area of only 127 µm × 125 µm using the 130 nm IBM CMOS process. In addition, the circuit dissipated less than 1 mW and was designed using thick-oxide 3.6 V NMOS and PMOS devices available in the process library.

  8. Simulation and Modeling of 24-Pulse STATCOM in EMTDC/PSCAD Program in Order to Regulate Voltage and Dynamic Stability Improvement

    Naser Parhizgar


    Full Text Available This study starts from the proof of Low Frequency Oscillation (LFO and then points out that there are many ways to study the LFO including its rejection measures. Also in this study one control system is planned in order to regulate voltage at common coupling point (PCC in where STATCOM is installed. This research present a single-machine infinite-bus system with one static synchronous compensator (STATCOM asymmetrically installed as a current source. Together with a classical generator model, the simplest power equation is obtained to give direct and clear physical concepts on synchronizing and damping torque factors. According to the primary equations, some basic issues, such as the relationship of voltage gain control and damping control, operating conditions, and the installation of STATCOM, are investigated in this research. Then, with assistance of proportional controller for voltage regulation and damp control, the digital simulation indicate the necessity of control of STATCOM in damping power system oscillations and supplying regulated voltage support.

  9. Study and development of a multiphase voltage regulation module; Estudio y desarrollo de un modulo de regulacion de voltaje multifase

    Sanchez Hernandez, Arturo


    Within the new generation of low voltage integrated circuits, the microprocessors constitute one of the applications that imposes the strictest regulation limits. Therefore, the requirements for the supplying sources oriented to feed these devices are more and more critical. The converters devoted to provide high currents at low output voltages with a fast dynamic response are known as Voltage Regulation Modules. The only way of maintaining the high efficiency of these feed sources is by means of the use of the Synchronous Rectifiers (SR), which implies the substitution of the conventional diodes by controlled devices of lesser tension drop, known as Synchronous Rectifiers (SR). The most convenient devices in applications of Synchronous Rectification are the MOSFET due to their low ignition resistance in addition of being able to operate at high commutation frequencies. Two forms exist by means of which we can operate the SR gate: by means of external excitation or by means of self-excitation. The conventional VRM has been based on the Buck topology with Synchronous Rectification. Nevertheless, due to the limitations that this topology presents as far as dynamic response and efficiency, it has been decided on the use of Multiphase VRM fed with an input bus on 48V. As a solution to these problems, in this research work a Multiphase VRM is proposed, based on the Half symmetrical Bridge converter with the primary windings connected in series and external Synchronous Rectification, with which it is possible to obtain a low output voltage with high current and a fast dynamic response. Next the contents of the chapters of this document of thesis are presented in a summarized way. In chapter 1 the background that gives rise to the necessity of designing power supplies with low output tension, is presented. The associated problems to this type of low tension DC/DC converters are mentioned, and the concept of Synchronous Rectification with external excitation is introduced

  10. Principle Analysis and Test of M-type Voltage Regulator%M型电压调节器的原理分析与检测



    The development of auto generator voltage regulator has gone through four stages: mechanical contact, transistor, integrated circuit, electronic control. The principle and test method of integrated circuit voltage regulator are analyzed with the example of DENSO M-type regulator.%汽车发电机电压调节器经历了机械触点式、晶体管式、集成电路式、微机控制式的发展。本文以电装M型电压调节器为例。分析集成电路电压调节器的原理及检测方法。

  11. Epigenetic regulation of L-type voltage-gated Ca(2+) channels in mesenteric arteries of aging hypertensive rats.

    Liao, Jingwen; Zhang, Yanyan; Ye, Fang; Zhang, Lin; Chen, Yu; Zeng, Fanxing; Shi, Lijun


    Accumulating evidence has shown that epigenetic regulation is involved in hypertension and aging. L-type voltage-gated Ca(2+) channels (LTCCs), the dominant channels in vascular myocytes, greatly contribute to arteriole contraction and blood pressure (BP) control. We investigated the dynamic changes and epigenetic regulation of LTCC in the mesenteric arteries of aging hypertensive rats. LTCC function was evaluated by using microvascular rings and whole-cell patch-clamp in the mesenteric arteries of male Wistar-Kyoto rats and spontaneously hypertensive rats at established hypertension (3 month old) and an aging stage (16 month old), respectively. The expression of the LTCC α1C subunit was determined in the rat mesenteric microcirculation. The expression of miR-328, which targets α1C mRNA, and the DNA methylation status at the promoter region of the α1C gene (CACNA1C) were also determined. In vitro experiments were performed to assess α1C expression after transfection of the miR-328 mimic into cultured vascular smooth muscle cells (VSMCs). The results showed that hypertension superimposed with aging aggravated BP and vascular remodeling. Both LTCC function and expression were significantly increased in hypertensive arteries and downregulated with aging. miR-328 expression was inhibited in hypertension, but increased with aging. There was no significant difference in the mean DNA methylation of CACNA1C among groups, whereas methylation was enhanced in the hypertensive group at specific sites on a CpG island located upstream of the gene promoter. Overexpression of miR-328 inhibited the α1C level of cultured VSMCs within 48 h. The results of the present study indicate that the dysfunction of LTCCs may exert an epigenetic influence at both pre- and post-transcriptional levels during hypertension pathogenesis and aging progression. miR-328 negatively regulated LTCC expression in both aging and hypertension.Hypertension Research advance online publication, 24

  12. Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized β subunit.

    Keum, Dongil; Baek, Christina; Kim, Dong-Il; Kweon, Hae-Jin; Suh, Byung-Chang


    G protein-coupled receptors (GPCRs) signal through molecular messengers, such as Gβγ, Ca(2+), and phosphatidylinositol 4,5-bisphosphate (PIP2), to modulate N-type voltage-gated Ca(2+) (CaV2.2) channels, playing a crucial role in regulating synaptic transmission. However, the cellular pathways through which GqPCRs inhibit CaV2.2 channel current are not completely understood. Here, we report that the location of CaV β subunits is key to determining the voltage dependence of CaV2.2 channel modulation by GqPCRs. Application of the muscarinic agonist oxotremorine-M to tsA-201 cells expressing M1 receptors, together with CaV N-type α1B, α2δ1, and membrane-localized β2a subunits, shifted the current-voltage relationship for CaV2.2 activation 5 mV to the right and slowed current activation. Muscarinic suppression of CaV2.2 activity was relieved by strong depolarizing prepulses. Moreover, when the C terminus of β-adrenergic receptor kinase (which binds Gβγ) was coexpressed with N-type channels, inhibition of CaV2.2 current after M1 receptor activation was markedly reduced and delayed, whereas the delay between PIP2 hydrolysis and inhibition of CaV2.2 current was decreased. When the Gβγ-insensitive CaV2.2 α1C-1B chimera was expressed, voltage-dependent inhibition of calcium current was virtually abolished, suggesting that M1 receptors act through Gβγ to inhibit CaV2.2 channels bearing membrane-localized CaV β2a subunits. Expression of cytosolic β subunits such as β2b and β3, as well as the palmitoylation-negative mutant β2a(C3,4S), reduced the voltage dependence of M1 muscarinic inhibition of CaV2.2 channels, whereas it increased inhibition mediated by PIP2 depletion. Together, our results indicate that, with membrane-localized CaV β subunits, CaV2.2 channels are subject to Gβγ-mediated voltage-dependent inhibition, whereas cytosol-localized β subunits confer more effective PIP2-mediated voltage-independent regulation. Thus, the voltage dependence of

  13. Dual regulation of the native ClC-K2 chloride channel in the distal nephron by voltage and pH.

    Pinelli, Laurent; Nissant, Antoine; Edwards, Aurélie; Lourdel, Stéphane; Teulon, Jacques; Paulais, Marc


    ClC-K2, a member of the ClC family of Cl(-) channels and transporters, forms the major basolateral Cl(-) conductance in distal nephron epithelial cells and therefore plays a central role in renal Cl(-) absorption. However, its regulation remains largely unknown because of the fact that recombinant ClC-K2 has not yet been studied at the single-channel level. In the present study, we investigate the effects of voltage, pH, Cl(-), and Ca(2+) on native ClC-K2 in the basolateral membrane of intercalated cells from the mouse connecting tubule. The ∼10-pS channel shows a steep voltage dependence such that channel activity increases with membrane depolarization. Intracellular pH (pHi) and extracellular pH (pHo) differentially modulate the voltage dependence curve: alkaline pHi flattens the curve by causing an increase in activity at negative voltages, whereas alkaline pHo shifts the curve toward negative voltages. In addition, pHi, pHo, and extracellular Ca(2+) strongly increase activity, mainly because of an increase in the number of active channels with a comparatively minor effect on channel open probability. Furthermore, voltage alters both the number of active channels and their open probability, whereas intracellular Cl(-) has little influence. We propose that changes in the number of active channels correspond to them entering or leaving an inactivated state, whereas modulation of open probability corresponds to common gating by these channels. We suggest that pH, through the combined effects of pHi and pHo on ClC-K2, might be a key regulator of NaCl absorption and Cl(-)/HCO3 (-) exchange in type B intercalated cells.

  14. 适用于动态电压恢复器电压检测的滤波算法%Filtering Method for Dynamic Voltage Regulator

    张强; 周晖; 齐智平


    动态电压恢复器(DVR)是目前治理电网动态电压问题中有效的手段之一,为了能够准确地监测电网电压的变化,数字滤波是DVR检测单元中必不可少的一个环节.采用幅值突变鉴别的电压增量惯性滤波法,既可以克服以往惯性滤波中时滞过大的缺点,又可以保证滤波后的电压波形在电压突变处的真实性,完全可以满足动态电压恢复器对检测单元滤波的需求.%Dynamic voltage regulator (DVR) is an efficacious measure to solve power quality problems. It is indispensable for DVR to adopt digital filter in its control system to detect voltage sags and swells accurately. Voltage increment inertial filter that can distinguish the sudden changes of voltage amplitude, can conquer the time delay problem of the conventional inertial filter, and ensure the creditability of filtered voltage waveform at the point of amplitude sudden change. So this filter method can meet the need of the test system of DVR perfectly.

  15. Neuroprotective effect of interleukin-6 regulation of voltage-gated Na+ channels of cortical neurons is time- and dose-dependent

    Wei Xia


    Full Text Available Interleukin-6 has been shown to be involved in nerve injury and nerve regeneration, but the effects of long-term administration of high concentrations of interleukin-6 on neurons in the central nervous system is poorly understood. This study investigated the effects of 24 hour exposure of interleukin-6 on cortical neurons at various concentrations (0.1, 1, 5 and 10 ng/mL and the effects of 10 ng/mL interleukin-6 exposure to cortical neurons for various durations (2, 4, 8, 24 and 48 hours by studying voltage-gated Na + channels using a patch-clamp technique. Voltage-clamp recording results demonstrated that interleukin-6 suppressed Na + currents through its receptor in a time- and dose-dependent manner, but did not alter voltage-dependent activation and inactivation. Current-clamp recording results were consistent with voltage-clamp recording results. Interleukin-6 reduced the action potential amplitude of cortical neurons, but did not change the action potential threshold. The regulation of voltage-gated Na + channels in rat cortical neurons by interleukin-6 is time- and dose-dependent.

  16. Neuroprotective effect of interleukin-6 regulation of voltage-gated Na(+) channels of cortical neurons is time- and dose-dependent.

    Xia, Wei; Peng, Guo-Yi; Sheng, Jiang-Tao; Zhu, Fang-Fang; Guo, Jing-Fang; Chen, Wei-Qiang


    Interleukin-6 has been shown to be involved in nerve injury and nerve regeneration, but the effects of long-term administration of high concentrations of interleukin-6 on neurons in the central nervous system is poorly understood. This study investigated the effects of 24 hour exposure of interleukin-6 on cortical neurons at various concentrations (0.1, 1, 5 and 10 ng/mL) and the effects of 10 ng/mL interleukin-6 exposure to cortical neurons for various durations (2, 4, 8, 24 and 48 hours) by studying voltage-gated Na(+) channels using a patch-clamp technique. Voltage-clamp recording results demonstrated that interleukin-6 suppressed Na(+) currents through its receptor in a time- and dose-dependent manner, but did not alter voltage-dependent activation and inactivation. Current-clamp recording results were consistent with voltage-clamp recording results. Interleukin-6 reduced the action potential amplitude of cortical neurons, but did not change the action potential threshold. The regulation of voltage-gated Na(+) channels in rat cortical neurons by interleukin-6 is time- and dose-dependent.

  17. Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption

    Miyauchi, A.; Hruska, K. A.; Greenfield, E. M.; Duncan, R.; Alvarez, J.; Barattolo, R.; Colucci, S.; Zambonin-Zallone, A.; Teitelbaum, S. L.; Teti, A.


    The mechanisms of Ca2+ entry and their effects on cell function were investigated in cultured chicken osteoclasts and putative osteoclasts produced by fusion of mononuclear cell precursors. Voltage-gated Ca2+ channels (VGCC) were detected by the effects of membrane depolarization with K+, BAY K 8644, and dihydropyridine antagonists. K+ produced dose-dependent increases of cytosolic calcium ([Ca2+]i) in osteoclasts on glass coverslips. Half-maximal effects were achieved at 70 mM K+. The effects of K+ were completely inhibited by dihydropyridine derivative Ca2+ channel blocking agents. BAY K 8644 (5 X 10(-6) M), a VGCC agonist, stimulated Ca2+ entry which was inhibited by nicardipine. VGCCs were inactivated by the attachment of osteoclasts to bone, indicating a rapid phenotypic change in Ca2+ entry mechanisms associated with adhesion of osteoclasts to their resorption substrate. Increasing extracellular Ca2+ ([Ca2+]e) induced Ca2+ release from intracellular stores and Ca2+ influx. The Ca2+ release was blocked by dantrolene (10(-5) M), and the influx by La3+. The effects of [Ca2+]e on [Ca2+]i suggests the presence of a Ca2+ receptor on the osteoclast cell membrane that could be coupled to mechanisms regulating cell function. Expression of the [Ca2+]e effect on [Ca2+]i was similar in the presence or absence of bone matrix substrate. Each of the mechanisms producing increases in [Ca2+]i, (membrane depolarization, BAY K 8644, and [Ca2+]e) reduced expression of the osteoclast-specific adhesion structure, the podosome. The decrease in podosome expression was mirrored by a 50% decrease in bone resorptive activity. Thus, stimulated increases of osteoclast [Ca2+]i lead to cytoskeletal changes affecting cell adhesion and decreasing bone resorptive activity.

  18. Static VAR Compensator-Based Voltage Regulation for Variable-Speed Prime Mover Coupled Single-Phase Self-Excited Induction Generator

    Ahmed, Tarek; Noro, Osamu; Hiraki, Eiji; Nakaoka, Mutsuo

    In this paper, the single-phase static VAR compensator (SVC) is applied to regulate and stabilize smoothly the generated output voltage of the single-phase self-excited induction generator (single-phase SEIG) driven by a variable-speed prime mover (VSPM) under the conditions of inductive load variations and prime mover speed changes. The conventional fixed gain PI controller-based feedback control scheme is employed to adjust the equivalent capacitance of the single-phase SVC composed of the fixed excitation capacitor (FC) in parallel with the thyristor switched capacitor (TSC) and the thyristor controlled reactor TCR. A PI closed-loop feedback voltage control scheme based on the SVC for the single-phase SEIG coupled by a VSPM prototype set-up is established. The closed-loop feedback output voltage responses in the single-phase SEIG coupled by a VSPM with different inductive load variations using the single-phase SVC with the PI controller are considered and discussed herein. Based on the SVC with the PI controller closed-loop feedback voltage regulation scheme, the experimental results for the single-phase SEIG driven by a VSPM are illustrated and proved its practical effectiveness in terms of the fast response and the high performances.

  19. 谈燃气调压器的选用及安装%Discussion on the selection and installation of gas voltage regulator



    In order to meet different pressure needs in urban gas transmission and application, the article describes the selection and installation of voltage regulation device according relevant experience, so as to guarantee safe and stable operation of voltage regulator in actual application and to ensure favorable development of gas industry.%为了满足城镇燃气在输配与应用过程中不同压力的需要,根据相关经验对调压装置的选用和安装进行了阐述,从而使调压器能在实际应用中安全稳定的运行,保证燃气事业的良好发展。

  20. Voltage-gated K(+) channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle.

    Chen, Muyan; Kellett, Whitney F; Petkov, Georgi V


    Members of the voltage-gated K(+) (K(V)) channel family are suggested to control the resting membrane potential and the repolarization phase of the action potential in urinary bladder smooth muscle (UBSM). Recent studies report that stromatoxin-1, a peptide isolated from tarantulas, selectively inhibits K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. The objective of this study was to investigate whether K(V) channels sensitive to stromatoxin-1 participate in the regulation of rat UBSM contractility and to identify their molecular fingerprints. Stromatoxin-1 (100 nM) increased the spontaneous phasic contraction amplitude, muscle force, and tone in isolated UBSM strips. However, stromatoxin-1 (100 nM) had no effect on the UBSM contractions induced by depolarizing agents such as KCl (20 mM) or carbachol (1 microM). This indicates that, under conditions of sustained membrane depolarization, the K(V) channels sensitive to stromatoxin-1 have no further contribution to the membrane excitability and contractility. Stromatoxin-1 (100 nM) increased the amplitude of the electrical field stimulation-induced contractions, suggesting also a role for these channels in neurogenic contractions. RT-PCR experiments on freshly isolated UBSM cells showed mRNA expression of K(V)2.1, K(V)2.2, and K(V)9.3, but not K(V)4.2 channel subunits. Protein expression of K(V)2.1 and K(V)2.2 channels was detected using Western blot and was further confirmed by immunocytochemical detection in freshly isolated UBSM cells. These novel findings indicate that K(V)2.1 and K(V)2.2, but not K(V)4.2, channel subunits are expressed in rat UBSM and play a key role in opposing both myogenic and neurogenic UBSM contractions.

  1. Differential regulation of voltage-gated Ca2+ currents and metabotropic glutamate receptor activity by measles virus infection in rat cortical neurons.

    Günther, Christine; Laube, Mandy; Liebert, Uwe-Gerd; Kraft, Robert


    Measles virus (MV) infection may lead to severe chronic CNS disease processes, including MV-induced encephalitis. Because the intracellular Ca(2+) concentration ([Ca(2+)](i)) is a major determinant of the (patho-)physiological state in all cells we asked whether important Ca(2+) conducting pathways are affected by MV infection in cultured cortical rat neurons. Patch-clamp measurements revealed a decrease in voltage-gated Ca(2+) currents during MV-infection, while voltage-gated K(+) currents and NMDA-evoked currents were unaffected. Calcium-imaging experiments using 50mM extracellular KCl showed reduced [Ca(2+)](i) increases in MV-infected neurons, confirming a decreased activity of voltage-gated Ca(2+) channels. In contrast, the group-I metabotropic glutamate receptor (mGluR) agonist DHPG evoked changes in [Ca(2+)](i) that were increased in MV-infected cells. Our results show that MV infection conversely regulates Ca(2+) signals induced by group-I mGluRs and by voltage-gated Ca(2+) channels, suggesting that these physiological impairments may contribute to an altered function of cortical neurons during MV-induced encephalitis.

  2. Neuroprotective effect of interleukin-6 regulation of voltage-gated Na+ channels of cortical neurons is time- and dose-dependent

    Wei Xia; Guo-yi Peng; Jiang-tao Sheng; Fang-fang Zhu; Jing-fang Guo; Wei-qiang Chen


    Interleukin-6 has been shown to be involved in nerve injury and nerve regeneration, but the effects of long-term administration of high concentrations of interleukin-6 on neurons in the central nervous system is poorly understood. This study investigated the effects of 24 hour expo-sure of interleukin-6 on cortical neurons at various concentrations (0.1, 1, 5 and 10 ng/mL) and the effects of 10 ng/mL interleukin-6 exposure to cortical neurons for various durations (2, 4, 8, 24 and 48 hours) by studying voltage-gated Na+ channels using a patch-clamp technique. Volt-age-clamp recording results demonstrated that interleukin-6 suppressed Na+ currents through its receptor in a time- and dose-dependent manner, but did not alter voltage-dependent activation and inactivation. Current-clamp recording results were consistent with voltage-clamp recording results. Interleukin-6 reduced the action potential amplitude of cortical neurons, but did not change the action potential threshold. The regulation of voltage-gated Na+channels in rat corti-cal neurons by interleukin-6 is time- and dose-dependent.

  3. Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.

    Santos-Sacchi, Joseph; Song, Lei


    In general, SLC26 solute carriers serve to transport a variety of anions across biological membranes. However, prestin (SLC26a5) has evolved, now serving as a motor protein in outer hair cells (OHCs) of the mammalian inner ear and is required for cochlear amplification, a mechanical feedback mechanism to boost auditory performance. The mechanical activity of the OHC imparted by prestin is driven by voltage and controlled by anions, chiefly intracellular chloride. Current opinion is that chloride anions control the Boltzmann characteristics of the voltage sensor responsible for prestin activity, including Qmax, the total sensor charge moved within the membrane, and Vh, a measure of prestin's operating voltage range. Here, we show that standard narrow-band, high-frequency admittance measures of nonlinear capacitance (NLC), an alternate representation of the sensor's charge-voltage (Q-V) relationship, is inadequate for assessment of Qmax, an estimate of the sum of unitary charges contributed by all voltage sensors within the membrane. Prestin's slow transition rates and chloride-binding kinetics adversely influence these estimates, contributing to the prevalent concept that intracellular chloride level controls the quantity of sensor charge moved. By monitoring charge movement across frequency, using measures of multifrequency admittance, expanded displacement current integration, and OHC electromotility, we find that chloride influences prestin kinetics, thereby controlling charge magnitude at any particular frequency of interrogation. Importantly, however, this chloride dependence vanishes as frequency decreases, with Qmax asymptoting at a level irrespective of the chloride level. These data indicate that prestin activity is significantly low-pass in the frequency domain, with important implications for cochlear amplification. We also note that the occurrence of voltage-dependent charge movements in other SLC26 family members may be hidden by inadequate

  4. A Voltage Regulation Strategy by Grid-Connected PV Inverters in Low-Voltage Networks%低压网络中并网光伏逆变器调压策略

    周林; 晁阳; 廖波; 晁朋飞; 杨明


    为解决光伏接入电网引起的并网点电压越限问题,增大光伏在电网中的渗透率,可充分利用并网光伏逆变器的无功调压能力向电网提供无功支撑。为此,从电网电压降落角度研究光伏发电接入电网前后并网点电压的变化,并深入分析了德国电气工程师协会(Verband Deutscher Elektrotechniker)提出的无功功率控制策略,在此基础上,提出一种基于并网点电压幅值与光伏有功出力的 Q(U,P)无功功率控制策略。该控制策略继承了德国电气工程师协会提出的策略的优点,在此控制策略下,光伏系统所有逆变器参与电网电压调节,在维持电网电压在要求范围的前提下,无功吸收总量最低,电网有功、无功损耗最小。算例结果验证了该策略的有效性。%In allusion to out-of-limit voltage at grid-connected point caused by grid-connection of photovoltaic (PV) system and raising the penetration rate of PV system on power grid, it is possible to fully utilize the reactive power regulation ability of grid-connected PV inverter to provide reactive power support to power grid. For this purpose, in the viewpoint of voltage drop the voltage variation at grid-connected point before and after the grid-connection of PV system is researched, and the reactive power control strategy given by Verband Deutscher Elektrotechniker (VDE) is analyzed in depth. On this basis, a reactive power control strategy based on voltage amplitude at grid-connected point and active output of PV system is proposed. This control strategy inherits the advantages of reactive power control strategy given by VDE, and under the proposed control strategy all PV inverters participate power grid voltage regulation, and under the premise of maintaining the grid voltage within the specified range the total absorbed amount of reactive power is the lowest and the active and reactive loss of power grid are minimized. The validity of the

  5. Large-conductance voltage- and Ca2+-activated K+ channel regulation by protein kinase C in guinea pig urinary bladder smooth muscle.

    Hristov, Kiril L; Smith, Amy C; Parajuli, Shankar P; Malysz, John; Petkov, Georgi V


    Large-conductance voltage- and Ca(2+)-activated K(+) (BK) channels are critical regulators of detrusor smooth muscle (DSM) excitability and contractility. PKC modulates the contraction of DSM and BK channel activity in non-DSM cells; however, the cellular mechanism regulating the PKC-BK channel interaction in DSM remains unknown. We provide a novel mechanistic insight into BK channel regulation by PKC in DSM. We used patch-clamp electrophysiology, live-cell Ca(2+) imaging, and functional studies of DSM contractility to elucidate BK channel regulation by PKC at cellular and tissue levels. Voltage-clamp experiments showed that pharmacological activation of PKC with PMA inhibited the spontaneous transient BK currents in native freshly isolated guinea pig DSM cells. Current-clamp recordings revealed that PMA significantly depolarized DSM membrane potential and inhibited the spontaneous transient hyperpolarizations in DSM cells. The PMA inhibitory effects on DSM membrane potential were completely abolished by the selective BK channel inhibitor paxilline. Activation of PKC with PMA did not affect the amplitude of the voltage-step-induced whole cell steady-state BK current or the single BK channel open probability (recorded in cell-attached mode) upon inhibition of all major Ca(2+) sources for BK channel activation with thapsigargin, ryanodine, and nifedipine. PKC activation with PMA elevated intracellular Ca(2+) levels in DSM cells and increased spontaneous phasic and nerve-evoked contractions of DSM isolated strips. Our results support the concept that PKC activation leads to a reduction of BK channel activity in DSM via a Ca(2+)-dependent mechanism, thus increasing DSM contractility.

  6. Voltage pre-regulator without insulation with high efficiency; Pre-regulador de tension sin aislamiento con alta eficiencia

    Lopez Ramos, Octaviano


    Nowadays there are problems caused by the inadequate and inefficient use of the electrical energy in the supplying systems, these problems are becoming more complicated with the passage of time, due to the proliferation of electronic equipment that does not incorporate some solutions to such problems. This has originated a tendency towards the development of systems that process with higher efficiency ({eta}) the electrical energy. In addition of making good use of the energy, they are designed so that they can correct the power factor (PF) and therefore reduce the contamination of harmonics in the network; which causes faults or destruction in other electronic equipment. Additionally it is possible to design them to obtain a good dynamic response, which assures that they can efficiently counteract load changes. The non-lineal characteristic that is present in all of the power supplies, which base its entrance on a rectification and filtration stage and, causes a low power factor (PF) and a high total harmonic distortion (THD). The factor is to contaminate the electric network, which can cause faults or breakdowns of other equipment. Since approximately 15 years the concern for solving this problem of the inadequate use of the energy has been taking importance, developing converters that correct the PF (pre-regulator) and that traditionally are connected in cascade with the typical stage of conversion of direct current to direct current (DC-DC) used to regulate the voltage; this solution has a low efficiency ({eta}) and high cost, by the excess of components connected in cascade. Nevertheless the dynamic response (DR) is adequate since it counts with separate stages for the correction of the PF and the regulation. From a revision of the state-of-the-art, in this thesis a new topology of pre-regulator for power supplies with a high efficiency is presented ({eta}), due to a novel strategy of managing the energy; also it corrects the PF. This represents an advance

  7. A 100 mA Low Voltage Linear Regulators for Systems on Chip Applications Using 0.18 {\\mu}m CMOS Technology

    Salah-ddine, Krit; Hassan, Qjidaa; Mohcine, Zouak


    A novel design for a low dropout (LDO) voltage regulator is presented and dedicated to power many sections of a typical cellular handset. However, these baseband, RF, and audio sections have different requirements that influence which LDO is most appropriate. After discussion of the specific requirements, different LDOs are recommended. Also, some LDO design techniques are briefly discussed to demonstrate how an LDO may be optimized for a specific level of performance. Cellular phone designs require linear regulators with lowdropout, low-noise, high PSRR, low quiescent current (Iq), and low-cost. They need to deliver a stable output and use smallvalue output capacitors. Ideally, one device would have all these characteristics and one low-dropout linear regulator (LDO) could be used anywhere in the phone without worry. But in practice, the various cell phone blocks are best powered by LDOs with different performance characteristics. This paper provides a new design methodology to choosing the right LDO to powe...

  8. Static DC to DC Power Conditioning-Active Ripple Filter, 1 MHZ DC to DC Conversion, and Nonlinear Analysis. Ph.D. Thesis; [voltage regulation and conversion circuitry for spacecraft power supplies

    Sander, W. A., III


    Dc to dc static power conditioning systems on unmanned spacecraft have as their inputs highly fluctuating dc voltages which they condition to regulated dc voltages. These input voltages may be less than or greater than the desired regulated voltages. The design of two circuits which address specific problems in the design of these power conditioning systems and a nonlinear analysis of one of the circuits are discussed. The first circuit design is for a nondissipative active ripple filter which uses an operational amplifier to amplify and cancel the sensed ripple voltage. A dc to dc converter operating at a switching frequency of 1 MHz is the second circuit discussed. A nonlinear analysis of the type of dc to dc converter utilized in designing the 1 MHz converter is included.

  9. Regulation of the forming process and the set voltage distribution of unipolar resistance switching in spin-coated CoFe2O4 thin films.

    Mustaqima, Millaty; Yoo, Pilsun; Huang, Wei; Lee, Bo Wha; Liu, Chunli


    We report the preparation of (111) preferentially oriented CoFe2O4 thin films on Pt(111)/TiO2/SiO2/Si substrates using a spin-coating process. The post-annealing conditions and film thickness were varied for cobalt ferrite (CFO) thin films, and Pt/CFO/Pt structures were prepared to investigate the resistance switching behaviors. Our results showed that resistance switching without a forming process is preferred to obtain less fluctuation in the set voltage, which can be regulated directly from the preparation conditions of the CFO thin films. Therefore, instead of thicker film, CFO thin films deposited by two times spin-coating with a thickness about 100 nm gave stable resistance switching with the most stable set voltage. Since the forming process and the large variation in set voltage have been considered as serious obstacles for the practical application of resistance switching for non-volatile memory devices, our results could provide meaningful insights in improving the performance of ferrite material-based resistance switching memory devices.


    Penin A.A.


    Full Text Available Regime characteristic values are determined relative to character values of regulation curve of switching regulator. Regime changing and the correspondence between various regime parameters are examined as a geometric (projective transformation. This makes possible to validate the regime definition, to restrict the range of their variation on the rising area of the control characteristic, to realize the linearization of this characteristic, to compare different pulse regulators.

  11. Feeder Voltage Regulation with High-Penetration PV Using Advanced Inverters and a Distribution Management System: A Duke Energy Case Study

    Palmintier, Bryan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Giraldez, Julieta [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gruchalla, Kenny [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gotseff, Peter [National Renewable Energy Lab. (NREL), Golden, CO (United States); Nagarajan, Adarsh [National Renewable Energy Lab. (NREL), Golden, CO (United States); Harris, Tom [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bugbee, Bruce [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baggu, Murali [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gantz, Jesse [GE Grid Solutions, Fairfield, CT (United States); Boardman, Ethan [GE Grid Solutions, Fairfield, CT (United States)


    Duke Energy, Alstom Grid, and the National Renewable Energy Laboratory teamed up to better understand the impacts of solar photovoltaics (PV) on distribution system operations. The core goal of the project is to compare the operational - specifically, voltage regulation - impacts of three classes of PV inverter operations: 1.) Active power only (Baseline); 2.) Local inverter control (e.g., PF...not equal...1, Q(V), etc.); and 3.) Integrated volt-VAR control (centralized through the distribution management system). These comparisons were made using multiple approaches, each of which represents an important research-and-development effort on its own: a) Quasi-steady-state time-series modeling for approximately 1 year of operations using the Alstom eTerra (DOTS) system as a simulation engine, augmented by Python scripting for scenario and time-series control and using external models for an advanced inverter; b) Power-hardware-in-the-loop (PHIL) testing of a 500-kVA-class advanced inverter and traditional voltage regulating equipment. This PHIL testing used cosimulation to link full-scale feeder simulation using DOTS in real time to hardware testing; c) Advanced visualization to provide improved insights into time-series results and other PV operational impacts; and d) Cost-benefit analysis to compare the financial and business-model impacts of each integration approach.

  12. Low Voltage Power Supply Incorporating Ceramic Transformer

    Imori, M


    A low voltage power supply provides the regulated output voltage of 1 V from the supply voltage around 48 V. The low voltage power supply incorporates a ceramic transformer which utilizes piezoelectric effect to convert voltage. The ceramic transformer isolates the secondary from the primary, thus providing the ground isolation between the supply and the output voltages. The ceramic transformer takes the place of the conventional magnetic transformer. The ceramic transformer is constructed from a ceramic bar and does not include any magnetic material. So the low voltage power supply can operate under a magnetic field. The output voltage is stabilized by feedback. A feedback loop consists of an error amplifier, a voltage controlled oscillator and a driver circuit. The amplitude ratio of the transformer has dependence on the frequency, which is utilized to stabilize the output voltage. The low voltage power supply is investigated on the analogy of the high voltage power supply similarly incorporating the cerami...

  13. Distributed Control of Inverter-Based Lossy Microgrids for Power Sharing and Frequency Regulation Under Voltage Constraints

    Chang, Chin-Yao; Zhang, Wei


    This paper presents a new distributed control framework to coordinate inverter-interfaced distributed energy resources (DERs) in island microgrids. We show that under bounded load uncertainties, the proposed control method can steer the microgrid to a desired steady state with synchronized inverter frequency across the network and proportional sharing of both active and reactive powers among the inverters. We also show that such convergence can be achieved while respecting constraints on voltage magnitude and branch angle differences. The controller is robust under various contingency scenarios, including loss of communication links and failures of DERs. The proposed controller is applicable to lossy mesh microgrids with heterogeneous R/X distribution lines and reasonable parameter variations. Simulations based on various microgrid operation scenarios are also provided to show the effectiveness of the proposed control method.

  14. 输电网络的分层分区电压无功调节方法%An Algorithm for Hierarchical and Partitioned Regulation of Voltage and Reactive Power in Transmission Network

    颜伟; 高强; 余娟; 杜跃明


    According to the principles of hierarchical and partitioned balance and local compensation of reactive power as well as the principle of contrary regulation of voltage, a method for voltage and reactive power regulation in transmission network is proposed. Firstly, the concepts such as partition in the same hierarchy and its load factor, reactive power regulation ability and unbalancedness degree of reactive power are defined and used to determine ideal targets of reactive power balance and contrary regulation of voltage and to evaluate reactive power balance level. On this basis, a hierarchical and partitioned regulation strategy of voltage and reactive power is put forward, and the regulation strategy consists of three stages: global voltage and reactive power regulation, hierarchical and partitioned regulation of voltage and reactive power and local regulation of voltage and ractive power of teminal substaions. The features of power flow in every single stage are analyzed and the regulation rules of voltage and reactive power in each stage are drafted for the aims of making the voltage of whole network conforming to the guide as well as implementing hierarchical and partitioned reactive power balance as possible. The availability of the proposed algurithm is verified by the results of calculation example.%基于无功的分层分区平衡与就地补偿原则、中枢点电压的逆调压原则,提出了输电网络电压无功调节方法.首先定义了同层区及其负载率、无功调节能力和无功不平衡度等概念,以此来确定无功平衡与逆调压的理想目标,评估电网的无功平衡水平.在此基础上提出了分层分区的电压无功调节策略,该策略包括3个阶段:1)全局电压无功调节;2)无功的分层分区平衡调节;3)终端变电站的局部电压与无功调节.分析了每个阶段的潮流特征,制定了各阶段的电压无功调节规则,尽可能实现全网的电压合格和分层分区的无功平衡.

  15. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.

    Nieves-Cintrón, Madeline; Hirenallur-Shanthappa, Dinesh; Nygren, Patrick J; Hinke, Simon A; Dell'Acqua, Mark L; Langeberg, Lorene K; Navedo, Manuel; Santana, Luis F; Scott, John D


    The Ca(2+)-responsive phosphatase calcineurin/protein phosphatase 2B dephosphorylates the transcription factor NFATc3. In the myocardium activation of NFATc3 down-regulates the expression of voltage-gated K(+) (Kv) channels after myocardial infarction (MI). This prolongs action potential duration and increases the probability of arrhythmias. Although recent studies infer that calcineurin is activated by local and transient Ca(2+) signals the molecular mechanism that underlies the process is unclear in ventricular myocytes. Here we test the hypothesis that sequestering of calcineurin to the sarcolemma of ventricular myocytes by the anchoring protein AKAP150 is required for acute activation of NFATc3 and the concomitant down-regulation of Kv channels following MI. Biochemical and cell based measurements resolve that approximately 0.2% of the total calcineurin activity in cardiomyocytes is associated with AKAP150. Electrophysiological analyses establish that formation of this AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following MI. Thus AKAP150-mediated targeting of calcineurin to sarcolemmal micro-domains in ventricular myocytes contributes to the local and acute gene remodeling events that lead to the down-regulation of Kv currents.

  16. A conserved threonine in the S1-S2 loop of KV7.2 and K V7.3 channels regulates voltage-dependent activation.

    Füll, Yvonne; Seebohm, Guiscard; Lerche, Holger; Maljevic, Snezana


    The voltage-gated potassium channels KV7.2 and KV7.3 (KCNQ2/3 genes) play an important role in regulating neuronal excitability. More than 50 KCNQ2/3 mutations have been identified to cause an inherited form of epilepsy in newborns. For two of those (E119G and S122L) found in the S1-S2 region of KV7.2, we previously showed a decreased channel availability mainly at action potential subthreshold voltages caused by a slight depolarizing shift of the activation curve. Interestingly, recent studies revealed that a threonine residue within the S1-S2 loop, highly conserved among different classes of KV channels, is crucial for both their function and surface expression. To investigate the functional role of the homologous threonine residues in KV7.2 (T114) and KV7.3 (T144) channels, we replaced them with alanine and examined the electrophysiological properties using heterologous expression in CHO cells and whole cell patch clamping. Channels comprising mutant subunits yielded decreased potassium currents with slowed activation and accelerated deactivation kinetics. However, the most striking effect was a depolarizing shift in the voltage dependence of activation reaching +30 mV upon co-expression of both mutant subunits. Potential interactions of T114 within the channel were analyzed by creating a 3D homology model of KV7.2 in an open state suggesting that this residue plays a central role in the formation of a stable interface between the S1-S2 and the S5 segment helices. This could be the explanation why substitution of the conserved threonine in KV7.2 and KV7.3 channels destabilizes the open and favors the closed state of these channels.

  17. Rab3 interacting molecule 3 mutations associated with autism alter regulation of voltage-dependent Ca²⁺ channels.

    Takada, Yoshinori; Hirano, Mitsuru; Kiyonaka, Shigeki; Ueda, Yoshifumi; Yamaguchi, Kazuma; Nakahara, Keiko; Mori, Masayuki X; Mori, Yasuo


    Autism is a neurodevelopmental psychiatric disorder characterized by impaired reciprocal social interaction, disrupted communication, and restricted and stereotyped patterns of interests. Autism is known to have a strong genetic component. Although mutations in several genes account for only a small proportion of individuals with autism, they provide insight into potential biological mechanisms that underlie autism, such as dysfunction in Ca(2+) signaling, synaptic dysfunction, and abnormal brain connectivity. In autism patients, two mutations have been reported in the Rab3 interacting molecule 3 (RIM3) gene. We have previously demonstrated that RIM3 physically and functionally interacts with voltage-dependent Ca(2+) channels (VDCCs) expressed in neurons via the β subunits, and increases neurotransmitter release. Here, by introducing corresponding autism-associated mutations that replace glutamic acid residue 176 with alanine (E176A) and methionine residue 259 with valine (M259V) into the C2B domain of mouse RIM3, we demonstrate that both mutations partly cancel the suppressive RIM3 effect on voltage-dependent inactivation of Ba(2+) currents through P/Q-type CaV2.1 recombinantly expressed in HEK293 cells. In recombinant N-type CaV2.2 VDCCs, the attenuation of the suppressive RIM3 effect on voltage-dependent inactivation is conserved for M259V but not E176A. Slowing of activation speed of P/Q-type CaV2.1 currents by RIM3 is abolished in E176A, while the physical interaction between RIM3 and β subunits is significantly attenuated in M259V. Moreover, increases by RIM3 in depolarization-induced Ca(2+) influx and acetylcholine release are significantly attenuated by E176A in rat pheochromocytoma PC12 cells. Thus, our data raise the interesting possibility that autism phenotypes are elicited by synaptic dysfunction via altered regulation of presynaptic VDCC function and neurotransmitter release.

  18. Design of Automatic Control System of Three-phase Voltage Regulating Based on Single-chip Microcomputer%基于单片机的三相调压自动控制系统的设计

    邢月华; 付磊; 薛章华


    针对传统的交流调压器难以满足实时、精确调压和稳压的问题,设计了一种基于单片机的三相调压自动控制系统,详细介绍了系统的硬件电路和软件的实现.该系统以AT89C51单片机为控制核心,可实时监测电压信号的变化,实现在设定电压下的手动、自动调压功能.该系统还可以实现0.01 V以上电压采集精度、0~400 V之间升压、降压及稳压的自动控制功能.试验结果表明,该系统具有电路简单,工作可靠性强和自动化水平高等优点.%Far problems that traditional AC voltage regulator is difficult to meet with real-time, precision regulator and voltage stabilization, an automatic control system of three-phase voltage regulating based on single-chip microcomputer was designed, realization of hardware circuit and software of the system were introduced in details. The system takes AT89C51 single-chip microcomputer as control core, can real-timely monitor change of voltage signal and achieve manual, automatic voltage regulating function according to set voltage. It also can achieve 0. 01 V voltage collection precision, automatic control functions of 0-400 V boost, buck and stabilization of voltage. The experiment results showed that the system has advatages such as simple circuit, strong work reliability and high automation level.

  19. Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels.

    Brennan, Sarah C; Finney, Brenda A; Lazarou, Maria; Rosser, Anne E; Scherf, Caroline; Adriaensen, Dirk; Kemp, Paul J; Riccardi, Daniela


    Airway branching morphogenesis in utero is essential for optimal postnatal lung function. In the fetus, branching morphogenesis occurs during the pseudoglandular stage (weeks 9-17 of human gestation, embryonic days (E)11.5-16.5 in mouse) in a hypercalcaemic environment (~1.7 in the fetus vs. ~1.1-1.3 mM for an adult). Previously we have shown that fetal hypercalcemia exerts an inhibitory brake on branching morphogenesis via the calcium-sensing receptor. In addition, earlier studies have shown that nifedipine, a selective blocker of L-type voltage-gated Ca(2+) channels (VGCC), inhibits fetal lung growth, suggesting a role for VGCC in lung development. The aim of this work was to investigate the expression of VGCC in the pseudoglandular human and mouse lung, and their role in branching morphogenesis. Expression of L-type (CaV1.2 and CaV1.3), P/Q type (CaV2.1), N-type (CaV2.2), R-type (CaV2.3), and T-type (CaV3.2 and CaV3.3) VGCC was investigated in paraffin sections from week 9 human fetal lungs and E12.5 mouse embryos. Here we show, for the first time, that Cav1.2 and Cav1.3 are expressed in both the smooth muscle and epithelium of the developing human and mouse lung. Additionally, Cav2.3 was expressed in the lung epithelium of both species. Incubating E12.5 mouse lung rudiments in the presence of nifedipine doubled the amount of branching, an effect which was partly mimicked by the Cav2.3 inhibitor, SNX-482. Direct measurements of changes in epithelial cell membrane potential, using the voltage-sensitive fluorescent dye DiSBAC2(3), demonstrated that cyclic depolarisations occur within the developing epithelium and coincide with rhythmic occlusions of the lumen, driven by the naturally occurring airway peristalsis. We conclude that VGCC are expressed and functional in the fetal human and mouse lung, where they play a role in branching morphogenesis. Furthermore, rhythmic epithelial depolarisations evoked by airway peristalsis would allow for branching to match

  20. Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels.

    Sarah C Brennan

    Full Text Available Airway branching morphogenesis in utero is essential for optimal postnatal lung function. In the fetus, branching morphogenesis occurs during the pseudoglandular stage (weeks 9-17 of human gestation, embryonic days (E11.5-16.5 in mouse in a hypercalcaemic environment (~1.7 in the fetus vs. ~1.1-1.3 mM for an adult. Previously we have shown that fetal hypercalcemia exerts an inhibitory brake on branching morphogenesis via the calcium-sensing receptor. In addition, earlier studies have shown that nifedipine, a selective blocker of L-type voltage-gated Ca(2+ channels (VGCC, inhibits fetal lung growth, suggesting a role for VGCC in lung development. The aim of this work was to investigate the expression of VGCC in the pseudoglandular human and mouse lung, and their role in branching morphogenesis. Expression of L-type (CaV1.2 and CaV1.3, P/Q type (CaV2.1, N-type (CaV2.2, R-type (CaV2.3, and T-type (CaV3.2 and CaV3.3 VGCC was investigated in paraffin sections from week 9 human fetal lungs and E12.5 mouse embryos. Here we show, for the first time, that Cav1.2 and Cav1.3 are expressed in both the smooth muscle and epithelium of the developing human and mouse lung. Additionally, Cav2.3 was expressed in the lung epithelium of both species. Incubating E12.5 mouse lung rudiments in the presence of nifedipine doubled the amount of branching, an effect which was partly mimicked by the Cav2.3 inhibitor, SNX-482. Direct measurements of changes in epithelial cell membrane potential, using the voltage-sensitive fluorescent dye DiSBAC2(3, demonstrated that cyclic depolarisations occur within the developing epithelium and coincide with rhythmic occlusions of the lumen, driven by the naturally occurring airway peristalsis. We conclude that VGCC are expressed and functional in the fetal human and mouse lung, where they play a role in branching morphogenesis. Furthermore, rhythmic epithelial depolarisations evoked by airway peristalsis would allow for branching to

  1. Benchmarking of Voltage Sag Generators

    Yang, Yongheng; Blaabjerg, Frede; Zou, Zhixiang


    The increased penetration of renewable energy systems, like photovoltaic and wind power systems, rises the concern about the power quality and stability of the utility grid. Some regulations for Low Voltage Ride-Through (LVRT) for medium voltage or high voltage applications, are coming into force...... to guide these grid-connected distributed power generation systems. In order to verify the response of such systems for voltage disturbance, mainly for evaluation of voltage sags/dips, a Voltage Sag Generator (VSG) is needed. This paper evaluates such sag test devices according to IEC 61000 in order...... to provide cheaper solutions to test against voltage sags. Simulation and experimental results demonstrate that the shunt impedance based VSG solution is the easiest and cheapest one for laboratory test applications. The back-to-back fully controlled converter based VSG is the most flexible solution...

  2. Efficient design and simulation of an expandable hybrid (wind-photovoltaic) power system with MPPT and inverter input voltage regulation features in compliance with electric grid requirements

    Skretas, Sotirios B.; Papadopoulos, Demetrios P. [Electrical Machines Laboratory, Department of Electrical and Computer Engineering, Democritos University of Thrace (DUTH), 12 V. Sofias, 67100 Xanthi (Greece)


    In this paper an efficient design along with modeling and simulation of a transformer-less small-scale centralized DC - bus Grid Connected Hybrid (Wind-PV) power system for supplying electric power to a single phase of a three phase low voltage (LV) strong distribution grid are proposed and presented. The main components of the hybrid system are: a PV generator (PVG); and an array of horizontal-axis, fixed-pitch, small-size, variable-speed wind turbines (WTs) with direct-driven permanent magnet synchronous generator (PMSG) having an embedded uncontrolled bridge rectifier. An overview of the basic theory of such systems along with their modeling and simulation via Simulink/MATLAB software package are presented. An intelligent control method is applied to the proposed configuration to simultaneously achieve three desired goals: to extract maximum power from each hybrid power system component (PVG and WTs); to guarantee DC voltage regulation/stabilization at the input of the inverter; to transfer the total produced electric power to the electric grid, while fulfilling all necessary interconnection requirements. Finally, a practical case study is conducted for the purpose of fully evaluating a possible installation in a city site of Xanthi/Greece, and the practical results of the simulations are presented. (author)

  3. Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin.

    Maldonado, Eduardo N; Sheldon, Kely L; DeHart, David N; Patnaik, Jyoti; Manevich, Yefim; Townsend, Danyelle M; Bezrukov, Sergey M; Rostovtseva, Tatiana K; Lemasters, John J


    Respiratory substrates and adenine nucleotides cross the mitochondrial outer membrane through the voltage-dependent anion channel (VDAC), comprising three isoforms--VDAC1, 2, and 3. We characterized the role of individual isoforms in mitochondrial metabolism by HepG2 human hepatoma cells using siRNA. With VDAC3 to the greatest extent, all VDAC isoforms contributed to the maintenance of mitochondrial membrane potential, but only VDAC3 knockdown decreased ATP, ADP, NAD(P)H, and mitochondrial redox state. Cells expressing predominantly VDAC3 were least sensitive to depolarization induced by increased free tubulin. In planar lipid bilayers, free tubulin inhibited VDAC1 and VDAC2 but not VDAC3. Erastin, a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. In conclusion, free tubulin inhibits VDAC1/2 and limits mitochondrial metabolism in HepG2 cells, contributing to the Warburg phenomenon. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism.

  4. The up-regulation of voltage-gated sodium channels subtypes coincides with an increased sodium current in hippocampal neuronal culture model.

    Guo, Feng; Xu, Xiaoxue; Cai, Jiqun; Hu, Huiyuan; Sun, Wei; He, Guilin; Shao, Dongxue; Wang, Lei; Chen, Tianbao; Shaw, Chris; Zhu, Tong; Hao, Liying


    Voltage-gated sodium channels (VGSC) have been linked to inherited forms of epilepsy. The expression and biophysical properties of VGSC in the hippocampal neuronal culture model have not been clarified. In order to evaluate mechanisms of epileptogenesis that are related to VGSC, we examined the expression and function of VGSC in the hippocampal neuronal culture model in vitro and spontaneously epileptic rats (SER) in vivo. Our data showed that the peak amplitude of transient, rapidly-inactivating Na(+) current (I(Na,T)) in model neurons was significantly increased compared with control neurons, and the activation curve was shifted to the negative potentials in model neurons in whole cell recording by patch-clamp. In addition, channel activity of persistent, non-inactivating Na(+) current (I(Na,P)) was obviously increased in the hippocampal neuronal culture model as judged by single-channel patch-clamp recording. Furthermore, VGSC subtypes Na(V)1.1, Na(V)1.2 and Na(V)1.3 were up-regulated at the protein expression level in model neurons and SER as assessed by Western blotting. Four subtypes of VGSC proteins in SER were clearly present throughout the hippocampus, including CA1, CA3 and dentate gyrus regions, and neurons expressing VGSC immunoreactivity were also detected in hippocampal neuronal culture model by immunofluorescence. These findings suggested that the up-regulation of voltage-gated sodium channels subtypes in neurons coincided with an increased sodium current in the hippocampal neuronal culture model, providing a possible explanation for the observed seizure discharge and enhanced excitability in epilepsy.

  5. Regulation of Guinea Pig Detrusor Smooth Muscle Excitability by 17β-Estradiol: The Role of the Large Conductance Voltage- and Ca2+-Activated K+ Channels.

    Provence, Aaron; Hristov, Kiril L; Parajuli, Shankar P; Petkov, Georgi V


    Estrogen replacement therapies have been suggested to be beneficial in alleviating symptoms of overactive bladder. However, the precise regulatory mechanisms of estrogen in urinary bladder smooth muscle (UBSM) at the cellular level remain unknown. Large conductance voltage- and Ca2+-activated K+ (BK) channels, which are key regulators of UBSM function, are suggested to be non-genomic targets of estrogens. This study provides an electrophysiological investigation into the role of UBSM BK channels as direct targets for 17β-estradiol, the principle estrogen in human circulation. Single BK channel recordings on inside-out excised membrane patches and perforated whole cell patch-clamp were applied in combination with the BK channel selective inhibitor paxilline to elucidate the mechanism of regulation of BK channel activity by 17β-estradiol in freshly-isolated guinea pig UBSM cells. 17β-Estradiol (100 nM) significantly increased the amplitude of depolarization-induced whole cell steady-state BK currents and the frequency of spontaneous transient BK currents in freshly-isolated UBSM cells. The increase in whole cell BK currents by 17β-estradiol was eliminated upon blocking BK channels with paxilline. 17β-Estradiol (100 nM) significantly increased (~3-fold) the single BK channel open probability, indicating direct 17β-estradiol-BK channel interactions. 17β-Estradiol (100 nM) caused a significant hyperpolarization of the membrane potential of UBSM cells, and this hyperpolarization was reversed by blocking the BK channels with paxilline. 17β-Estradiol (100 nM) had no effects on L-type voltage-gated Ca2+ channel currents recorded under perforated patch-clamp conditions. This study reveals a new regulatory mechanism in the urinary bladder whereby BK channels are directly activated by 17β-estradiol to reduce UBSM cell excitability.

  6. Voltage-gated potassium currents are targets of diurnal changes in estradiol feedback regulation and kisspeptin action on gonadotropin-releasing hormone neurons in mice.

    Pielecka-Fortuna, Justyna; DeFazio, R Anthony; Moenter, Suzanne M


    Estradiol has both negative and positive feedback actions upon gonadotropin-releasing hormone (GnRH) release; the latter actions trigger the preovulatory GnRH surge. Although neurobiological mechanisms of the transitions between feedback modes are becoming better understood, the roles of voltage-gated potassium currents, major contributors to neuronal excitability, are unknown. Estradiol alters two components of potassium currents in these cells: a transient current, I(A), and a sustained current, I(K). Kisspeptin is a potential mediator between estradiol and GnRH neurons and can act directly on GnRH neurons. We examined how estradiol, time of day, and kisspeptin interact to regulate these conductances in a mouse model exhibiting daily switches between estradiol negative (morning) and positive feedback (evening). Whole-cell voltage clamp recordings were made from GnRH neurons in brain slices from ovariectomized (OVX) mice and from OVX mice treated with estradiol (OVX+E). There were no diurnal changes in either I(A) or I(K) in GnRH neurons from OVX mice. In contrast, in GnRH neurons from OVX+E mice, I(A) and I(K) were greater during the morning when GnRH neuron activity is low and smaller in the evening when GnRH neuron activity is high. Estradiol increased I(A) in the morning and decreased it in the evening, relative to that in cells from OVX mice. Exogenously applied kisspeptin reduced I(A) regardless of time of day or estradiol status. Estradiol, interacting with time of day, and kisspeptin both depolarized I(A) activation. These findings extend our understanding of both the neurobiological mechanisms of estradiol negative vs. positive regulation of GnRH neurons and of kisspeptin action on these cells.

  7. Voltage-gated potassium channel Kvl.3 in rabbit ciliary epithelium regulates the membrane potential via coupling intracellular calcium

    LI Yan-feng; ZHUO Ye-hong; BI Wei-na; BAI Yu-jing; LI Yan-na; WANG Zhi-jian


    Background The cell layer of the ciliary epithelium is responsible for aqueous humor secretion and maintenance.Ion channels play an important role in these processes.The main aim of this study was to determine whether the well-characterized members of the Kvl family (Kv1.3) contribute to the Kv currents in ciliary epithelium.Methods New Zealand White rabbits were maintained in a 12 hours light/dark cycle.Ciliary epithelium samples were isolated from the rabbits.We used Western blotting and immunocytochemistry to identify the expression and location of a voltage-gated potassium channel Kvl.3 in ciliary body epithelium.Membrane potential change after adding of Kv1.3 inhibitor margatoxin (MgTX) was observed with a fluorescence method.Results Western blotting and immunocytochemical studies showed that the Kv1.3 protein expressed in pigment ciliary epithelium and nonpigment ciliary epithelium,however it seemed to express more in the apical membrane of the nonpigmented epithelial cells.One nmol/L margatoxin,a specific inhibitor of Kv1.3 channels caused depolarization of the cultured nonpigmented epithelium (NPE) membrane potential.The cytosotic calcium increased after NPE cell depolarization,this increase of cytosolic calcium was partially blocked by 12.5 μmol/L dantrolene and 10 μmol/L nifedipine.These observations suggest that Kv1.3 channels modulate ciliary epithelium potential and effect calcium dependent mechanisms.Conclusion Kv1.3 channels contribute to K+ efflux at the membrane of rabbit ciliary epithelium.

  8. Adenine nucleotides and intracellular Ca2+ regulate a voltage-dependent and glucose-sensitive potassium channel in neurosecretory cells.

    Onetti, C G; Lara, J; García, E


    Effects of membrane potential, intracellular Ca2+ and adenine nucleotides on glucose-sensitive channels from X organ (XO) neurons of the crayfish were studied in excised inside-out patches. Glucose- sensitive channels were selective to K+ ions; the unitary conductance was 112 pS in symmetrical K+, and the K+ permeability (PK) was 1.3 x 10(-13) cm x s(-1). An inward rectification was observed when intracellular K+ was reduced. Using a quasi-physiological K+ gradient, a non-linear K+ current/voltage relationship was found showing an outward rectification and a slope conductance of 51 pS. The open-state probability (Po) increased with membrane depolarization as a result of an enhancement of the mean open time and a shortening of the longer period of closures. In quasi-physio- logical K+ concentrations, the channel was activated from a threshold of about -60 mV, and the activation midpoint was -2 mV. Po decreased noticeably at 50 microM internal adenosine 5'-triphosphate (ATP), and single-channel activity was totally abolished at 1 mM ATP. Hill analysis shows that this inhibition was the result of simultaneous binding of two ATP molecules to the channel, and the half-blocking concentration of ATP was 174 microM. Internal application of 5'-adenylylimidodiphosphate (AMP-PNP) as well as glibenclamide also decreased Po. By contrast, the application of internal ADP (0.1 to 2 mM) activated this channel. An optimal range of internal free Ca2+ ions (0.1 to 10 microM) was required for the activation of this channel. The glucose--sensitive K+ channel of XO neurons could be considered as a subtype of ATP-sensitive K+ channel, contributing substantially to macroscopic outward current.

  9. IMC控制在双凸极发电机电压调节中的应用%Application of IMC Control on Voltage Regulation of A Doubly Salient Generator

    陈志辉; 严仰光


    The paper presents the hardware platform of the digital voltage regulator,which is based on a DSP chip——TMS320C32,to fit the n eed for voltage regulation of a doubly-salient DC generator.And the IMC control algorithm os adopted in the hardware platform.In the experiment on a brushless doubly-salient DC generator,the digital voltage regulator results in good responses.%针对双凸极无刷直流发电机的调压要求,设计了以 TMS320C32为核心的数字调压器硬件平台。采用内模控制算法的数字调压在对双凸极无刷直 流发电机进行调压实验的过程中,取得了良好的控制效果。

  10. S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK channels

    Michael J Shipston


    Full Text Available Mechanisms that control surface expression and/or activity of large conductance calcium-activated potassium (BK channels are important determinants of their (pathophysiological function. Indeed, BK channel dysfunction is associated with major human disorders ranging from epilepsy to hypertension and obesity. S-acylation (S-palmitoylation represents a major reversible, post-translational modification controlling the properties and function of many proteins including ion channels. Recent evidence reveals that both pore-forming and regulatory subunits of BK channels are S-acylated and control channel trafficking and regulation by AGC-family protein kinases. The pore-forming α-subunit is S-acylated at two distinct sites within the N- and C-terminus, each site being regulated by different palmitoyl acyl transferases (zDHHCs and acyl thioesterases. (APTs. S-acylation of the N-terminus controls channel trafficking and surface expression whereas S-acylation of the C-terminal domain determines regulation of channel activity by AGC-family protein kinases. S-acylation of the regulatory β4-subunit controls ER exit and surface expression of BK channels but does not affect ion channel kinetics at the plasma membrane. Furthermore, a significant number of previously identified BK-channel interacting proteins have been shown, or are predicted to be, S-acylated. Thus, the BK channel multi-molecular signalling complex may be dynamically regulated by this fundamental post-translational modification and thus S-acylation likely represents an important determinant of BK channel physiology in health and disease.

  11. Regulated dc-to-dc converter for voltage step-up or step-down with input-output isolation

    Feng, S. Y.; Wilson, T. G. (Inventor)


    A closed loop regulated dc-to-dc converter employing an unregulated two winding inductive energy storage converter is provided by using a magnetically coupled multivibrator acting as duty cycle generator to drive the converter. The multivibrator is comprised of two transistor switches and a saturable transformer. The output of the converter is compared with a reference in a comparator which transmits a binary zero until the output exceeds the reference. When the output exceeds the reference, the binary output of the comparator drives transistor switches to turn the multivibrator off. The multivibrator is unbalanced so that a predetermined transistor will always turn on first when the binary feedback signal becomes zero.

  12. Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.

    Jensen, Mette V; Haldeman, Jonathan M; Zhang, Hengtao; Lu, Danhong; Huising, Mark O; Vale, Wylie W; Hohmeier, Hans E; Rosenberg, Paul; Newgard, Christopher B


    Recent studies have shown that the pyruvate-isocitrate cycling pathway, involving the mitochondrial citrate/isocitrate carrier and the cytosolic NADP-dependent isocitrate dehydrogenase (ICDc), is involved in control of glucose-stimulated insulin secretion (GSIS). Here we demonstrate that pyruvate-isocitrate cycling regulates expression of the voltage-gated potassium channel family member Kv2.2 in islet β-cells. siRNA-mediated suppression of ICDc, citrate/isocitrate carrier, or Kv2.2 expression impaired GSIS, and the effect of ICDc knockdown was rescued by re-expression of Kv2.2. Moreover, chronic exposure of β-cells to elevated fatty acids, which impairs GSIS, resulted in decreased expression of Kv2.2. Surprisingly, knockdown of ICDc or Kv2.2 increased rather than decreased outward K(+) current in the 832/13 β-cell line. Immunoprecipitation studies demonstrated interaction of Kv2.1 and Kv2.2, and co-overexpression of the two channels reduced outward K(+) current compared with overexpression of Kv2.1 alone. Also, siRNA-mediated knockdown of ICDc enhanced the suppressive effect of the Kv2.1-selective inhibitor stromatoxin1 on K(+) currents. Our data support a model in which a key function of the pyruvate-isocitrate cycle is to maintain levels of Kv2.2 expression sufficient to allow it to serve as a negative regulator of Kv channel activity.

  13. Regulation of neuronal high-voltage activated Ca(V)2 Ca(2+) channels by the small GTPase RhoA.

    Rousset, Matthieu; Cens, Thierry; Menard, Claudine; Bowerman, Melissa; Bellis, Michel; Brusés, Juan; Raoul, Cedric; Scamps, Frédérique; Charnet, Pierre


    High-Voltage-Activated (HVA) Ca(2+) channels are known regulators of synapse formation and transmission and play fundamental roles in neuronal pathophysiology. Small GTPases of Rho and RGK families, via their action on both cytoskeleton and Ca(2+) channels are key molecules for these processes. While the effects of RGK GTPases on neuronal HVA Ca(2+) channels have been widely studied, the effects of RhoA on the HVA channels remains however elusive. Using heterologous expression in Xenopus laevis oocytes, we show that RhoA activity reduces Ba(2+) currents through CaV2.1, CaV2.2 and CaV2.3 Ca(2+) channels independently of CaVβ subunit. This inhibition occurs independently of RGKs activity and without modification of biophysical properties and global level of expression of the channel subunit. Instead, we observed a marked decrease in the number of active channels at the plasma membrane. Pharmacological and expression studies suggest that channel expression at the plasma membrane is impaired via a ROCK-sensitive pathway. Expression of constitutively active RhoA in primary culture of spinal motoneurons also drastically reduced HVA Ca(2+) current amplitude. Altogether our data revealed that HVA Ca(2+) channels regulation by RhoA might govern synaptic transmission during development and potentially contribute to pathophysiological processes when axon regeneration and growth cone kinetics are impaired.

  14. 适合学校实验室使用的节能型稳压器设计%Design of energy-saving voltage regulators suitable for school laboratories

    刘福启; 周鹏; 蒋方剑; 赵红霞


      学校实验室精密仪器设备一般都配备稳压器,以保证仪器的正常使用,然而稳压器的能源损耗是一大浪费。如何降低稳压器的能源损耗,让市电在安全电压范围内时,使稳压器自动脱离电源,将市电直接供给负载,消除稳压器自身损耗;负载为零时,也使稳压器自动脱离电源,消除其空载损耗,让稳压器的能源损耗降至最低,又能发挥稳压器应有的作用,经试制,达到了设计功能。%In order to ensure the normal use, school laboratory precision instruments are generally equipped with voltage regulators. However, the use of regulators is a big waste of energy loss. How to reduce the energy loss of voltage regulators by keeping AC in safe voltage range and voltage regulators off the power supply automatically so as to enable AC to supply load directly? When the load is zero, regulators can also automatically cut from the power supply and eliminate the no-load loss. The energy loss of voltage regulators has been reduced to the lowest point and the due functions of regulators have been ensured. The trials prove that the design has achieved desired purposes.

  15. Involvement of inositol 1,4,5-trisphosphate formation in the voltage-dependent regulation of the Ca(2+) concentration in porcine coronary arterial smooth muscle cells.

    Yamamura, Hisao; Ohya, Susumu; Muraki, Katsuhiko; Imaizumi, Yuji


    The involvement of inositol 1,4,5-trisphosphate (IP(3)) formation in the voltage-dependent regulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) was examined in smooth muscle cells of the porcine coronary artery. Slow ramp depolarization from -90 to 0 mV induced progressive [Ca(2+)](i) increase. The slope was reduced or increased in the presence of Cd(2+) or (±)-1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-[trifluoromethyl]-phenyl)pyridine-3-carboxlic acid methyl ester (Bay K 8644), respectively. The decrease in [Ca(2+)](i) via the membrane hyperpolarization induced by K(+) channel openers (levcromakalim and Evans blue) under current clamp was identical to that under voltage clamp. The step hyperpolarization from -40 to -80 mV reduced [Ca(2+)](i) uniformly over the whole-cell area with a time constant of ∼10 s. The [Ca(2+)](i) at either potential was unaffected by heparin, an inhibitor of IP(3) receptors. Alternatively, [Ca(2+)](i) rapidly increased in the peripheral regions by depolarization from -80 to 0 mV and stayed at that level (∼400 nM) during a 60-s pulse. When the pipette solution contained IP(3) pathway blockers [heparin, 2-aminoethoxydiphenylborate, xestospongin C, or 1-[6-[((17β)-3-methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione (U73122)], the peak [Ca(2+)](i) was unchanged, but the sustained [Ca(2+)](i) was gradually reduced by ∼250 nM within 30 s. In the presence of Cd(2+), a long depolarization period slightly increased the [Ca(2+)](i), which was lower than that in the presence of heparin alone. In coronary arterial myocytes, the sustained increase in the [Ca(2+)](i) during depolarization was partly caused by the Ca(2+) release mediated by the enhanced formation of IP(3). The initial [Ca(2+)](i) elevation triggered by the Ca(2+) influx though voltage-dependent Ca(2+) channels may be predominantly responsible for the activation of phospholipase C for IP(3) formation.

  16. 基于LDO电压调整器的带隙基准电压源设计%Based on the LDO voltage regulator of design of band-gap voltage reference

    张颖斐; 姜生瑞; 郭丽芳


    设计一款应用于电压调整器(LDO)的带隙基准电压源。电压基准是模拟电路设计必不可缺少的一个单元模块,带隙基准电压源为LDO提供一个精确的参考电压,是LDO系统设计关键模块之一。本文设计的带隙基准电压源采用0.5μm标准的CMOS工艺实现。为了提高电压抑制性,采用了低压共源共栅的电流镜结构,并且在基准内部设计了一个运算放大器,合理的运放设计进一步提高了电源抑制性。基于Cadence的Spectre进行前仿真验证,结果表明该带隙基准电压源具有较低的变化率、较小的温漂系数和较高的电源抑制比,其对抗电源变化和温度变化特性较好。%Design of an applied voltage regnlator ( LDO ) to the bandgap reference voltage source. Voltage reference is indispensable to a unit module to analog circuit design, Bandgap reference voltage source to provide a precise reference voltage for the LDO, It Is one of the key modules of the LDO system design. In this paper, the design of bandgap voltage reference with 0.5 pL m standard CMOS technology. In order to improve the voltage suppressor, adopts a low-voltage cascode current mirror structure, and in the base internal design of an operational amplifier, a reasonable operational amplifier design further improve power s suppressor. Based on the Cadence Spectre simulation validation, The results show that the band gap reference voltage source has a low rate of change, small temperature drift coefficient and high power supply, its combat power change and temperature change characteristics of good.

  17. MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats

    Songxue Su


    Full Text Available Nav1.3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are closely associated with neuropathic pain. It can be up-regulated following nerve injury, but its biological function remains uncertain. MicroRNAs (miRNAs are endogenous non-coding RNAs that can regulate post-transcriptional gene expression by binding with their target mRNAs. Using Target Scan software, we discovered that SCN3A is the major target of miR-30b, and we then determined whether miR-30b regulated the expression of Nav1.3 by transfecting miR-30b agomir through the stimulation of TNF-α or by transfecting miR-30b antagomir in primary dorsal root ganglion (DRG neurons. The spinal nerve ligation (SNL model was used to determine the contribution of miR-30b to neuropathic pain, to evaluate changes in Nav1.3 mRNA and protein expression, and to understand the sensitivity of rats to mechanical and thermal stimuli. Our results showed that miR-30b agomir transfection down-regulated Nav1.3 mRNA stimulated with TNF-α in primary DRG neurons. Moreover, miR-30b overexpression significantly attenuated neuropathic pain induced by SNL, with decreases in the expression of Nav1.3 mRNA and protein both in DRG neurons and spinal cord. Activation of Nav1.3 caused by miR-30b antagomir was identified. These data suggest that miR-30b is involved in the development of neuropathic pain, probably by regulating the expression of Nav1.3, and might be a novel therapeutic target for neuropathic pain.Perspective: This study is the first to explore the important role of miR-30b and Nav1.3 in spinal nerve ligation-induced neuropathic pain, and our evidence may provide new insight for improving therapeutic approaches to pain.

  18. 49 CFR 234.221 - Lamp voltage.


    ... 49 Transportation 4 2010-10-01 2010-10-01 false Lamp voltage. 234.221 Section 234.221 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., Inspection, and Testing Maintenance Standards § 234.221 Lamp voltage. The voltage at each lamp shall...

  19. Evidence for functional interaction of plasma membrane electron transport, voltage-dependent anion channel and volume-regulated anion channel in frog aorta

    Rashmi P Rao; J Prakasa Rao


    Frog aortic tissue exhibits plasma membrane electron transport (PMET) owing to its ability to reduce ferricyanide even in the presence of mitochondrial poisons, such as cyanide and azide. Exposure to hypotonic solution (108 mOsmol/kg H2O) enhanced the reduction of ferricyanide in excised aortic tissue of frog. Increment in ferricyanide reductase activity was also brought about by the presence of homocysteine (100 M dissolved in isotonic frog Ringer solution), a redox active compound and a potent modulator of PMET. Two plasma-membrane-bound channels, the volume regulated anion channel (VRAC) and the voltage-dependent anion channel (VDAC), are involved in the response to hypotonic stress. The presence of VRAC and VDAC antagonists–tamoxifen, glibenclamide, fluoxetine and verapamil, and 4,4′-diisothiocyanatostilbene-2,2′-disulphonic acid (DIDS), respectively–inhibited this enhanced activity brought about by either hypotonic stress or homocysteine. The blockers do not affect the ferricyanide reductase activity under isotonic conditions. Taken together, these findings indicate a functional interaction of the three plasma membrane proteins, namely, ferricyanide reductase (PMET), VDAC and VRAC.

  20. Reconstitution of neurotoxin-modulated ion transport by the voltage-regulated sodium channel isolated from the electroplax of Electrophorus electricus.

    Rosenberg, R L; Tomiko, S A; Agnew, W S


    The functional reconstitution of the voltage-regulated Na channel purified from the electroplax of Electrophorus electricus is described. Reconstitution was achieved by removing detergent with Bio-Beads SM-2 followed by freeze-thaw-sonication in the presence of added liposomes. This preparation displayed heat-stable binding of 3H-labeled tetrodotoxin (TTX) (Kd = 33 nM). 22Na+ influx was stimulated 2- to 5-fold by alkaloid neurotoxins and blocked by TTX. Veratridine activated Na+ influx with a K1/2 of 18 microM, and this activation was blocked by TTX precisely in parallel with specific [3H]TTX binding. Batrachotoxin stimulated 22Na+ flux more effectively than did veratridine. No effect of the peptide anemone toxin II was found. Insertion of the Na channel into membranes resulted in 60-70% of the TTX-binding sites facing the vesicle exterior. Thus, external TTX partially inhibited flux, whereas blockade was complete when TTX was also equilibrated with the vesicle interior. The lipid-soluble local anesthetics tetracaine and dibucaine inhibited flux completely. QX-222, a charged derivative of lidocaine, blocked only a fraction of the channels, apparently those oriented inside-out. Purified samples were predominantly composed of the Mr 260,000-300,000 glycopeptide but contained variable quantities of smaller peptides. Veratridine-dependent flux and peptide compositions were determined on fractions across a gel filtration column profile. Stimulated flux codistributed only with the large peptide. Images PMID:6322191

  1. Serum Starvation-Induced Voltage-Gated Potassium Channel Kv7.5 Expression and Its Regulation by Sp1 in Canine Osteosarcoma Cells

    Bo Hyung Lee


    Full Text Available The KCNQ gene family, whose members encode Kv7 channels, belongs to the voltage-gated potassium (Kv channel group. The roles of this gene family have been widely investigated in nerve and muscle cells. In the present study, we investigated several characteristics of Kv7.5, which is strongly expressed in the canine osteosarcoma cell line, CCL-183. Serum starvation upregulated Kv7.5 expression, and the Kv7 channel opener, flupirtine, attenuated cell proliferation by arresting cells in the G0/G1 phase. We also showed that Kv7.5 knockdown helps CCL-183 cells to proliferate. In an effort to find an endogenous regulator of Kv7.5, we used mithramycin A to reduce the level of the transcription factor Sp1, and it strongly inhibited the induction of Kv7.5 in CCL-183 cells. These results suggest that the activation of Kv7.5 by flupirtine may exert an anti-proliferative effect in canine osteosarcoma. Therefore, Kv7.5 is a possible molecular target for canine osteosarcoma therapy.

  2. An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation.

    Limpitikul, Worawan B; Dick, Ivy E; Ben-Johny, Manu; Yue, David T


    CaV1.3 channels are a major class of L-type Ca(2+) channels which contribute to the rhythmicity of the heart and brain. In the brain, these channels are vital for excitation-transcription coupling, synaptic plasticity, and neuronal firing. Moreover, disruption of CaV1.3 function has been associated with several neurological disorders. Here, we focus on the de novo missense mutation A760G which has been linked to autism spectrum disorder (ASD). To explore the role of this mutation in ASD pathogenesis, we examined the effects of A760G on CaV1.3 channel gating and regulation. Introduction of the mutation severely diminished the Ca(2+)-dependent inactivation (CDI) of CaV1.3 channels, an important feedback system required for Ca(2+) homeostasis. This reduction in CDI was observed in two major channel splice variants, though to different extents. Using an allosteric model of channel gating, we found that the underlying mechanism of CDI reduction is likely due to enhanced channel opening within the Ca(2+)-inactivated mode. Remarkably, the A760G mutation also caused an opposite increase in voltage-dependent inactivation (VDI), resulting in a multifaceted mechanism underlying ASD. When combined, these regulatory deficits appear to increase the intracellular Ca(2+) concentration, thus potentially disrupting neuronal development and synapse formation, ultimately leading to ASD.

  3. Accurate Switched-Voltage voltage averaging circuit

    金光, 一幸; 松本, 寛樹


    Abstract ###This paper proposes an accurate Switched-Voltage (SV) voltage averaging circuit. It is presented ###to compensated for NMOS missmatch error at MOS differential type voltage averaging circuit. ###The proposed circuit consists of a voltage averaging and a SV sample/hold (S/H) circuit. It can ###operate using nonoverlapping three phase clocks. Performance of this circuit is verified by PSpice ###simulations.

  4. Modular high voltage power supply for chemical analysis

    Stamps, James F.; Yee, Daniel D.


    A high voltage power supply for use in a system such as a microfluidics system, uses a DC-DC converter in parallel with a voltage-controlled resistor. A feedback circuit provides a control signal for the DC-DC converter and voltage-controlled resistor so as to regulate the output voltage of the high voltage power supply, as well as, to sink or source current from the high voltage supply.

  5. Digital constant current source based on the adjustable voltage regulator%基于可调稳压芯片的数控恒流源



    Briefly discusses the design of DC constant current source, and discusses the existing devices, analyses their disadvantages,mainly introduces an efficient digital controlled constant current source which is based on adjustable voltage regulator. The schematic diagram of the circuit is given. The author introduces the principle of the system and the relation parameter in detail. Kernel model and feedback model are introduced from the point of view of system composition. The principle of the system is using the kernel chip's feedback pin, changing the parallel feedback to serial feedback. This system has function of current preset and low current ripple etc. An instrument developed by the author employs the constant current circuit designed in this paper and has got popular applications.%针对数控直流恒流源的设计进行了探讨,对比已有的恒流源实现方式,分析了其缺点,重点介绍1种高效率的基于可调稳压芯片的数控恒流源.给出了电路原理图,就整机工作原理、相关参数计算做了详细介绍.从系统组成角度分别介绍了核心模块、反馈模块及其实现方法.其基本原理是利用核心芯片的反馈引脚,把并联反馈改为串联反馈,从而实现恒流性能.系统具有输出电流可预置,输出纹波电流低等特性.采用设计的恒流源电路在自行研制的某仪器已推广应用.

  6. Regulation of voltage-gated Ca(2+) currents by Ca(2+)/calmodulin-dependent protein kinase II in resting sensory neurons.

    Kostic, Sandra; Pan, Bin; Guo, Yuan; Yu, Hongwei; Sapunar, Damir; Kwok, Wai-Meng; Hudmon, Andy; Wu, Hsiang-En; Hogan, Quinn H


    Calcium/calmodulin-dependent protein kinase II (CaMKII) is recognized as a key element in encoding depolarization activity of excitable cells into facilitated voltage-gated Ca(2+) channel (VGCC) function. Less is known about the participation of CaMKII in regulating VGCCs in resting cells. We examined constitutive CaMKII control of Ca(2+) currents in peripheral sensory neurons acutely isolated from dorsal root ganglia (DRGs) of adult rats. The small molecule CaMKII inhibitor KN-93 (1.0μM) reduced depolarization-induced ICa by 16-30% in excess of the effects produced by the inactive homolog KN-92. The specificity of CaMKII inhibition on VGCC function was shown by the efficacy of the selective CaMKII blocking peptide autocamtide-2-related inhibitory peptide in a membrane-permeable myristoylated form, which also reduced VGCC current in resting neurons. Loss of VGCC currents is primarily due to reduced N-type current, as application of mAIP selectively reduced N-type current by approximately 30%, and prior N-type current inhibition eliminated the effect of mAIP on VGCCs, while prior block of L-type channels did not reduce the effect of mAIP on total ICa. T-type currents were not affected by mAIP in resting DRG neurons. Transduction of sensory neurons in vivo by DRG injection of an adeno-associated virus expressing AIP also resulted in a loss of N-type currents. Together, these findings reveal a novel molecular adaptation whereby sensory neurons retain CaMKII support of VGCCs despite remaining quiescent.


    D. S. Biluhin


    Full Text Available The possibility of application of the modern power semiconductor keys is considered for realization of asynchronous method of control of voltage level for circuits of on-board feeding of electric locomotives.

  8. 双凸极电机数字调压系统的设计与实现%Design and realization of digital voltage regulation system for double-salient genertor

    赵徐成; 王余奎; 吕恒俊; 邹楠


    Excitation system is the core of generator's generating system. Recently, the excitation system of generator tends to use single manager to realize its digitization. A digital voltage regulation system for double-salient electro-magnetic generator was designed based on DSP. The experiment validates the feasibility and stability of the voltage regulation system. The digital excitation voltage regulation for double-salient generation was realized.%励磁调压系统是发电机发电系统的核心部分,近年来,发电机励磁调压系统趋向于使用信号处理器来实现数字化.设计了基于DSP的电励磁双凸极电机的数字调压系统,通过实验验证了所设计调压系统的可行性和稳定性,实现了双凸极电机的数字励磁调压.

  9. 7800系列三端固定集成稳压器应用电路的可靠性设计%Reliability Design of Application Circuit for 7800 Series Three Terminal Positive Voltage Regulator


    The article introduced the working principle for 7800 series three terminal posi-tive voltage regulator. At the same time, based on the statistic fault data of three terminal positive voltage regulator, it can be classified for five kind fault characteristics. And com-bining the working principle of 7800 series and energy characteristics of the power supply, the five kind of the fault characteristics were analyzed. Finally, the article presented the methods for reliability design of application circuit for 7800 series three terminal positive voltage regulator. The methods are simple to use and have high reliability, and verified in application.%  简介:本文介绍了7800系列三端固定集成稳压器的工作原理。同时根据已统计的三端固定集成稳压器故障数据,归类于五种故障特征,并结合7800系列的工作原理和电源的能量特征对这五种故障进行了分析。最后给出7800系列三端固定集成稳压器应用电路的可靠性设计的方法。这些方法简单实效,且可靠性强,已得到了实际应用验证。

  10. 基于MCU控制的开关电源稳压电路设计%Design for voltage regulator circuit of switching power supply based on MCU control

    李淑红; 邢军


    A voltage regulator circuit of the switching power supply based on MCU control was designed,which is com-posed of rectification filtering circuit,push-pull power conversion circuit and control circuit. In this circuit,the output voltage of the switching power supply is controlled by regulating PWM via the MCU. The digital signal output by MCU is converted into analog signal through the DAC0832. The analog signal is taken as the reference voltage of the second pin of the switching con-trol chip SG3525. SG3525 generates PWM control pulse automatically according to the variation of reference voltage to regulate the output pulse width of the switching tube,so the purpose of regulating the output voltage is achieved. The experimental re-sults show that the output voltage adjustable range is 28~36 V,the maximum output current is 15 A,and the efficiency of the switching power supply is 89%.%设计了一款基于MCU控制的开关电源稳压电路,该系统主要由整流滤波电路、推挽式功率变换电路和控制电路组成,并通过MCU调节PWM控制开关电源输出电压.MCU输出的数字信号通过DAC0832转换为模拟信号,该模拟信号作为开关控制芯片SG3525第二管脚的基准电压,SG3525根据基准电压的变化自动产生PWM控制脉冲,调节开关管的输出脉宽,从而达到调节输出电压的目的.实验表明,输出电压可调范围为28~36 V,最大输出电流Imax=15 A,开关电源的效率为η=89%.

  11. 无刷直流电动机调压系统BUCK直流变换仿真%Simulation on BUCK DC Transformer of Brushless DC Motor Voltage Regulation System



    In order to improve the brushless DC motor voltage regulation system voltage conversion efficiency and reduce power consumption, based on BUCK transformer chopper voltage regulation technology was put forward. In this paper elaborat-ed the circuit structure and mathematical model of brushless DC motor with BUCK mode, analyzed technology of DC converter and BUCK dc transform. Take advantage of MATLAB software SIMULINK module modeling BUCK DC converter, simula-tion for BUCK DC transform under the 20kHz working frequency, got the switch tube gate trigger pulse, inductive voltage and inductance current, output voltage, switching tube and diode current simulation curve. The simulation results and theoretical analysis of waveform basically the same, the rationality was proved of BUCK DC converter model.%为了提高无刷直流电动机调压系统电压转换效率、降低功率消耗,提出基于BUCK变换的斩波调压技术。在阐述BUCK模式下无刷直流电动机电路结构、数学模型基础上,对直流变换器和BUCK直流变换技术进行分析。利用MATLAB软件SIMULINK模块对BUCK直流变换器进行建模,对20kHz工作频率下BUCK直流变换进行仿真,得到开关管门极触发脉冲、电感电压、电感电流、输出电压、开关管电流和二极管电流仿真曲线。仿真结果与理论分析波形基本一致,表明BUCK直流变换器模型的合理性。

  12. Evaluation of the Voltage Support Strategies for the Low Voltage Grid Connected PV

    Demirok, Erhan; Sera, Dezso; Teodorescu, Remus


    PVs. In order to increase PV penetration level further, new voltage support control functions for individual inverters are required. This paper investigates distributed reactive power regulation and active power curtailment strategies regarding the development of PV connection capacity by evaluation......Admissible range of grid voltage is one of the strictest constraints for the penetration of distributed photovoltaic (PV) generators especially connection to low voltage (LV) public networks. Voltage limits are usually fulfilled either by network reinforcements or limiting of power injections from...

  13. 绕线式异步电动机调压节能运行研究%Research on the Operation Performance of Wound Rotor Asynchronous Motors in Voltage Regulation and Energy Saving

    冯韧; 王兵; 侯黎平


    Based on the fact that asynchronous motors are characterized with periodic load operation, the optimal voltage of wound rotor asynchronous motors has been determined under no-load and light-load operating modes. With the load ratio a constant, the power factor under the optimal voltage is greater than that under the rated voltage. In light of the features of winding rotor asynchronous motors, a research has been conducted on the side series resistance starting and the capacity of voltage regulation and energy-saving series under series resistance speed regulation. When a resistance of 2 is connected in series with the rotor circuit, an accelerated starting of the motor has thus achieved. With the optimal voltage a constant, the electromagnetic torque remains constant before and after the series resistance has been connected with the rotor circuit. A step-down series resistance speed regulation model of wound rotor asynchronous motors has been set up to work out the relationship between the energy consumption of the rotor turn-on and rotor series resistance under a constant optimal voltage. When the load factor of the motor is in the range of 0%~50%, a certain energy-saving space could be obtained by appropriately reducing the power supply voltage, thus verifying the feasibility of the energy saving operation under the light load rotor series resistance voltage regulation of wound rotor asynchronous motors under the optimal voltage.%根据异步电动机带周期性负载运行的特点,确定了绕线式异步电动机处于空载、轻载运行状态下的最优电压,且维持负载率不变时,其在最优电压下的功率因数大于其在额定电压下的。针对绕线式异步电动机的特性,研究了其转子侧串电阻启动及串电阻调速下调压节能的运行状态,得知当转子回路中串入2电阻时,可加速电机启动,且在最优电压一定时,串电阻前后的电磁转矩恒定。通过搭建绕线式异步电动

  14. Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.

    Sara Dizayee

    Full Text Available BACKGROUND: Two pertussis toxin sensitive G(i proteins, G(i2 and G(i3, are expressed in cardiomyocytes and upregulated in heart failure. It has been proposed that the highly homologous G(i isoforms are functionally distinct. To test for isoform-specific functions of G(i proteins, we examined their role in the regulation of cardiac L-type voltage-dependent calcium channels (L-VDCC. METHODS: Ventricular tissues and isolated myocytes were obtained from mice with targeted deletion of either Gα(i2 (Gα(i2 (-/- or Gα(i3 (Gα(i3 (-/-. mRNA levels of Gα(i/o isoforms and L-VDCC subunits were quantified by real-time PCR. Gα(i and Ca(vα(1 protein levels as well as protein kinase B/Akt and extracellular signal-regulated kinases 1/2 (ERK1/2 phosphorylation levels were assessed by immunoblot analysis. L-VDCC function was assessed by whole-cell and single-channel current recordings. RESULTS: In cardiac tissue from Gα(i2 (-/- mice, Gα(i3 mRNA and protein expression was upregulated to 187 ± 21% and 567 ± 59%, respectively. In Gα(i3 (-/- mouse hearts, Gα(i2 mRNA (127 ± 5% and protein (131 ± 10% levels were slightly enhanced. Interestingly, L-VDCC current density in cardiomyocytes from Gα(i2 (-/- mice was lowered (-7.9 ± 0.6 pA/pF, n = 11, p<0.05 compared to wild-type cells (-10.7 ± 0.5 pA/pF, n = 22, whereas it was increased in myocytes from Gα(i3 (-/- mice (-14.3 ± 0.8 pA/pF, n = 14, p<0.05. Steady-state inactivation was shifted to negative potentials, and recovery kinetics slowed in the absence of Gα(i2 (but not of Gα(i3 and following treatment with pertussis toxin in Gα(i3 (-/-. The pore forming Ca(vα(1 protein level was unchanged in all mouse models analyzed, similar to mRNA levels of Ca(vα(1 and Ca(vβ(2 subunits. Interestingly, at the cellular signalling level, phosphorylation assays revealed abolished carbachol-triggered activation of ERK1/2 in mice lacking Gα(i2. CONCLUSION: Our data provide novel evidence for an isoform

  15. 基于分区电网的多机进相调压效益探析%Voltage Regulation Effects of Leading phase Operation of Multi-generators in District Grids

    韦延方; 卫志农; 孙国强; 王成亮


    发电机进相运行是解决系统低谷运行时枢纽点电压偏高的有效手段。针对江苏省2010年实际背景分区电网,选择若干组已投运的机组,以分类分区研究单机进相的调压作用为基础,对多机进相运行进行仿真,分析进相运行对分区关键母线电压的影响和对系统电压的调节作用,并校验多机进相运行时系统的暂态稳定性,探讨分区内多机进相运行的调压能力。%Leading phase operation of generators is an effective method to reduce voltage of the key point which is much high in valley load period.Several generating units in operation in the district grid of Jiangsu province in 2010 were selected as the research targets.Then the research analyzed the influence of leading phase of multi-generators on the key bus voltage based on the voltage regulation effects of leading phase of single-generator in classification and subarea method.The transient stability of leading phase of multi-generators was verified,and the voltage regulation capability of leading phase of multi-generators was analyzed.

  16. Unified Power Quality Conditioner for voltage and current compensation

    P.Annapandi; Dr.M.Rajaram


    This paper deals with a Unified Power Quality Conditioner (UPQC) for load balancing, power factorcorrection, voltage regulation, voltage and current harmonics mitigation, mitigation of voltage sag, swelland voltage dip in a three-phase three-wire distribution system for different combinations of linear and nonlinear loads.The unified power quality conditioner (UPQC) is a combination of back to back connected shunt and series active power filters (APFs) to a common DC link voltage, which compe...

  17. A Synchrophasor Based Optimal Voltage Control Scheme with Successive Voltage Stability Margin Improvement

    Heng-Yi Su


    Full Text Available This paper proposes an optimal control scheme based on a synchronized phasor (synchrophasor for power system secondary voltage control. The framework covers voltage stability monitoring and control. Specifically, a voltage stability margin estimation algorithm is developed and built in the newly designed adaptive secondary voltage control (ASVC method to achieve more reliable and efficient voltage regulation in power systems. This new approach is applied to improve voltage profile across the entire power grid by an optimized plan for VAR (reactive power sources allocation; therefore, voltage stability margin of a power system can be increased to reduce the risk of voltage collapse. An extensive simulation study on the IEEE 30-bus test system is carried out to demonstrate the feasibility and effectiveness of the proposed scheme.

  18. Regulation of voltage-gated calcium channels by proteolysis%蛋白质水解对电压门控Ca2+通道的调节

    ABELE Kathryn; 杨建


    电压门控Ca2+通道是由多个亚基组成的膜蛋白,其分布广泛,生理功能极为重要,可被众多蛋白和信号传导通路调节.本综述重点介绍蛋白质水解对电压门控Ca2+通道的调节作用及其生理功能.Ca2+通道的主亚基Cavα1可被蛋白质水解,从而调控Ca2+通道的功能和降解,影响基因表达和细胞兴奋性.根据其组织分布,L类Ca2+通道有两种水解模式:在心脏和骨骼肌,Cavα1的羧基末端被水解后与剩余的羧基端结合,抑制Ca2+通道电流.这种自身抑制可被体内分泌的肾上腺素解除,引发心肌和骨骼肌Ca2+电流大量增加,在“打或逃”之类的应激反应中起重要作用,Cavα1羧基末端水解在大脑也存在,并可能是由calpain蛋白质水解酶催化;在某些大脑区域,Cavα1的整个羧基端可被水解并迁移至细胞核,起到转录因子的作用.P/Q类Ca2+通道Cavα1的羧基末端也可被水解,并迁移到细胞核.许多基因突变产生截断型P/Q Cavα1,而这些截断型Cavα1可严重影响正常Ca2+通道的功能,导致人类的疾病.截断型N类Ca2+通道Cavα1可通过诱变产生,影响正常通道的表达.新型Ca2+通道水解新模式可能是未来Ca2+通道研究中一个重要的探索方向.%Voltage gated calcium channels (VGCCs) are multi-subunit membrane proteins present in a variety of tissues and control many essential physiological processes.Due to their vital importance,VGCCs are regulated by a myriad of proteins and signaling pathways.Here we review the literature on the regulation of VGCCs by proteolysis of the pore-forming α1 subunit,Cavα1.This form of regulation modulates channel function and degradation and affects cellular gene expression and excitability.L-type Ca2+ channels are proteolyzed in two ways,depending on tissue localization.In the heart and skeletal muscle,the distal C-terminus of Cavα1 is cleaved and acts as an autoinhibitor when it reassociates with the proximal C

  19. Method for Improve the Design of Diode Voltage Regulator Circuit for Solar Calculator%一种改进太阳能计算器芯片二极管稳压电路设计



      For solar energy calculator, the voltage regulator circuit is composed by three PN junction diodes in series. The design may cause some issue:because of the higher Vf for voltage regulator circuit, the voltage of solar energy battery is too higher to arouse voltage can not release in time when sunlight is strong. These issue will lead to calculator can not work well. This paper improve the design of diode voltage regulator circuit. One PN junction diode be changed to shottky diode by change P+mask. So the Vf get more reasonable range than ever. What is more, the impact is researched on thickness of Ti layer and temperature. Finally, it show that this improvement fit our requirement.%  对于太阳能计算器,稳压电路的设计是串联三个PN结二极管以达到稳压目的。这种设计会出现以下问题:当外部光线太强时,太阳能电池板的供电电压较高,而稳压电路由于正向饱和压降过高,不能及时将高电压释放掉,会造成计算器不能正常工作。文章研究了改进二极管稳压电路的设计,通过只变更其中的一层mask(P+),将其中一个PN结二极管改为肖特基二极管,使其正向饱和压降处于一个合理的区间,并且研究了通过该变动后不同的Ti金属厚度以及不同温度对该稳压电路的影响。结果显示该种优化完全符合应用需求。

  20. Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex.

    Barrett, Paula Q; Guagliardo, Nick A; Klein, Peter M; Hu, Changlong; Breault, David T; Beenhakker, Mark P


    Zona glomerulosa cells (ZG) of the adrenal gland constantly integrate fluctuating ionic, hormonal and paracrine signals to control the synthesis and secretion of aldosterone. These signals modulate Ca(2+) levels, which provide the critical second messenger to drive steroid hormone production. Angiotensin II is a hormone known to modulate the activity of voltage-dependent L- and T-type Ca(2+) channels that are expressed on the plasma membrane of ZG cells in many species. Because the ZG cell maintains a resting membrane voltage of approximately -85 mV and has been considered electrically silent, low voltage-activated T-type Ca(2+) channels are assumed to provide the primary Ca(2+) signal that drives aldosterone production. However, this view has recently been challenged by human genetic studies identifying somatic gain-of-function mutations in L-type CaV 1.3 channels in aldosterone-producing adenomas of patients with primary hyperaldosteronism. We provide a review of these assumptions and challenges, and update our understanding of the state of the ZG cell in a layer in which native cellular associations are preserved. This updated view of Ca(2+) signalling in ZG cells provides a unifying mechanism that explains how transiently activating CaV 3.2 channels can generate a significant and recurring Ca(2+) signal, and how CaV 1.3 channels may contribute to the Ca(2+) signal that drives aldosterone production.

  1. Parameter estimation of stable models and with minimum phase in dynamic aggregation of voltage regulators; Estimacao de parametros de modelos estaveis e de fase minima na agregacao dinamica de reguladores de tensao

    Souza, E.J.S. Pires de [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio), Rio de Janeiro, RJ (Brazil). Dept. de Engenharia Eletrica], E-mail:


    The dynamic aggregation of coherent generating unit models has been solved as an unconstrained optimization problem. In this process, negative time constants may be obtained, which characterize unstable or non-minimal phase models. The comparison of the solutions of the dynamic aggregation problem of voltage regulator models obtained with both the original formulation and the squared-variable transformation is the objective of this paper. Initial values are within the range from +100% to -90% in relation to the estimated parameters. The New England system including models of the Brazilian system is considered in the studies. (author)

  2. A Low Voltage High PSRR Reference Source Based on Regulated Current Mode Structure%基于电流控制模式的低压、高PSRR基准源

    张慧敏; 周云; 王璐霞; 袁凯


    A new bandgap voltage reference circuit with low voltage .high power supply rejection ratio (PSRR) based on a regulated current mode structure is presented. The proposed circuit utilizes a regulated current mode structure and some feedback loops to improve the overall PSRR. Using resistive subdivision reaches a low voltage and provides the bias voltage of transistors,simplified bias circuit. The circuit was designed with 0. 5μn complementary metal oxide semiconductor transistor (CMOS) N - well technology, which worked at 1.5V power voltage. Cadence Spectre simulation results show PSRR is 107dB at low frequencies, the temperature coefficient from - 10°C to 125°C temperature range is 7.17 ppm/°C and the power consumption is only 0. 525mW. This circuit shows robustness against process variation.%基于可调电流控制模式设计出一种低压、高电源抑制比的带隙基准电压源电路.采用电流控制模式和多反馈环路,提高电路的整体电源抑制比;通过电阻分压的方式,使电路达到低压,同时提供偏压,简化偏置电路.采用0.5μmCMOS N阱工艺,电路可在电源电压为1.5V时正常工作.使用Cadence Spectre进行仿真结果表明,低频时电源抑制比(PSRR)高达107dB.- 10℃~125℃温度范围内,平均温度系数约7.17ppm/℃,功耗仅为0.525mW.此电路能有效地抑制制程变异.

  3. Transient Voltage Recorder

    Medelius, Pedro J. (Inventor); Simpson, Howard J. (Inventor)


    A voltage transient recorder can detect lightning induced transient voltages. The recorder detects a lightning induced transient voltage and adjusts input amplifiers to accurately record transient voltage magnitudes. The recorder stores voltage data from numerous monitored channels, or devices. The data is time stamped and can be output in real time, or stored for later retrieval. The transient recorder, in one embodiment, includes an analog-to-digital converter and a voltage threshold detector. When an input voltage exceeds a pre-determined voltage threshold, the recorder stores the incoming voltage magnitude and time of arrival. The recorder also determines if its input amplifier circuits clip the incoming signal or if the incoming signal is too low. If the input data is clipped or too low, the recorder adjusts the gain of the amplifier circuits to accurately acquire subsequent components of the lightning induced transients.

  4. Research on impedance characteristics of voltage regulator module in high-performance computer%高性能计算机中电压调节模块阻抗特性研究

    姚信安; 宋飞; 胡世平


    To solve system instability caused by the interaction between individually designed power modules/sub-systems in high-performance computer, the input and output impedance characteristics of voltage regulator module for multi-core processor were thoroughly studied. The small-signal model and system block diagram of voltage regulator module were developed, and various transfer functions were presented. Then, the feedback compensator was designed, and the open-loop and closed-loop impedance characteristics were simulated and measured. The simulation and measurement results lay a foundation for the improvement of system stability.%针对高性能计算机中电源模块或子系统之间相互作用而导致的不稳定性问题,详细研究了多核处理器电压调节模块的输入输出阻抗特性.建立了电压调节模块的小信号模型和系统框图,求出了各种传递函数,设计了反馈补偿回路,并对开环和闭环阻抗特性进行了仿真和实际测量.仿真和测量结果为解决系统稳定性问题打下了基础.

  5. Automatic voltage imbalance detector

    Bobbett, Ronald E.; McCormick, J. Byron; Kerwin, William J.


    A device for indicating and preventing damage to voltage cells such as galvanic cells and fuel cells connected in series by detecting sequential voltages and comparing these voltages to adjacent voltage cells. The device is implemented by using operational amplifiers and switching circuitry is provided by transistors. The device can be utilized in battery powered electric vehicles to prevent galvanic cell damage and also in series connected fuel cells to prevent fuel cell damage.

  6. Mixed voltage VLSI design

    Panwar, Ramesh; Rennels, David; Alkalaj, Leon


    A technique for minimizing the power dissipated in a Very Large Scale Integration (VLSI) chip by lowering the operating voltage without any significant penalty in the chip throughput even though low voltage operation results in slower circuits. Since the overall throughput of a VLSI chip depends on the speed of the critical path(s) in the chip, it may be possible to sustain the throughput rates attained at higher voltages by operating the circuits in the critical path(s) with a high voltage while operating the other circuits with a lower voltage to minimize the power dissipation. The interface between the gates which operate at different voltages is crucial for low power dissipation since the interface may possibly have high static current dissipation thus negating the gains of the low voltage operation. The design of a voltage level translator which does the interface between the low voltage and high voltage circuits without any significant static dissipation is presented. Then, the results of the mixed voltage design using a greedy algorithm on three chips for various operating voltages are presented.

  7. Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity.

    Bourdin, Céline M; Moignot, Bénédicte; Wang, Lingxin; Murillo, Laurence; Juchaux, Marjorie; Quinchard, Sophie; Lapied, Bruno; Guérineau, Nathalie C; Dong, Ke; Legros, Christian


    Insect voltage-gated sodium (Nav) channels are formed by a well-known pore-forming α-subunit encoded by para-like gene and ancillary subunits related to TipE from the mutation "temperature-induced-paralysis locus E." The role of these ancillary subunits in the modulation of biophysical and pharmacological properties of Na(+) currents are not enough documented. The unique neuronal ancillary subunit TipE-homologous protein 1 of Drosophila melanogaster (DmTEH1) strongly enhances the expression of insect Nav channels when heterologously expressed in Xenopus oocytes. Here we report the cloning and functional expression of two neuronal DmTEH1-homologs of the cockroach, Periplaneta americana, PaTEH1A and PaTEH1B, encoded by a single bicistronic gene. In PaTEH1B, the second exon encoding the last 11-amino-acid residues of PaTEH1A is shifted to 3'UTR by the retention of a 96-bp intron-containing coding-message, thus generating a new C-terminal end. We investigated the gating and pharmacological properties of the Drosophila Nav channel variant (DmNav1-1) co-expressed with DmTEH1, PaTEH1A, PaTEH1B or a truncated mutant PaTEH1Δ(270-280) in Xenopus oocytes. PaTEH1B caused a 2.2-fold current density decrease, concomitant with an equivalent α-subunit incorporation decrease in the plasma membrane, compared to PaTEH1A and PaTEH1Δ(270-280). PaTEH1B positively shifted the voltage-dependences of activation and slow inactivation of DmNav1-1 channels to more positive potentials compared to PaTEH1A, suggesting that the C-terminal end of both proteins may influence the function of the voltage-sensor and the pore of Nav channel. Interestingly, our findings showed that the sensitivity of DmNav1-1 channels to lidocaine and to the pyrazoline-type insecticide metabolite DCJW depends on associated TEH1-like subunits. In conclusion, our work demonstrates for the first time that density, gating and pharmacological properties of Nav channels expressed in Xenopus oocytes can be modulated by an

  8. Secondary Voltage Control for Harmonics Suppression in Islanded Microgrids

    Wang, Xiongfei; Guerrero, Josep M.; Blaabjerg, Frede


    This paper proposes a secondary voltage waveform control approach to suppress harmonics in islanded microgrids. Compared with the secondary control for traditional large power systems, the proposed control scheme can regulate the voltage waveform instead of voltage magnitude of sensitive buses in...

  9. A new functional role for mechanistic/mammalian target of rapamycin complex 1 (mTORC1) in the circadian regulation of L-type voltage-gated calcium channels in avian cone photoreceptors.

    Huang, Cathy Chia-Yu; Ko, Michael Lee; Ko, Gladys Yi-Ping


    In the retina, the L-type voltage-gated calcium channels (L-VGCCs) are responsible for neurotransmitter release from photoreceptors and are under circadian regulation. Both the current densities and protein expression of L-VGCCs are significantly higher at night than during the day. However, the underlying mechanisms of circadian regulation of L-VGCCs in the retina are not completely understood. In this study, we demonstrated that the mechanistic/mammalian target of rapamycin complex (mTORC) signaling pathway participated in the circadian phase-dependent modulation of L-VGCCs. The activities of the mTOR cascade, from mTORC1 to its downstream targets, displayed circadian oscillations throughout the course of a day. Disruption of mTORC1 signaling dampened the L-VGCC current densities, as well as the protein expression of L-VGCCs at night. The decrease of L-VGCCs at night by mTORC1 inhibition was in part due to a reduction of L-VGCCα1 subunit translocation from the cytosol to the plasma membrane. Finally, we showed that mTORC1 was downstream of the phosphatidylionositol 3 kinase-protein kinase B (PI3K-AKT) signaling pathway. Taken together, mTORC1 signaling played a role in the circadian regulation of L-VGCCs, in part through regulation of ion channel trafficking and translocation, which brings to light a new functional role for mTORC1: the modulation of ion channel activities.

  10. The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy.

    Huang, Yangliang; Zang, Ying; Zhou, Lijun; Gui, Wenshan; Liu, Xianguo; Zhong, Yi


    Diabetic neuropathy (DN) is a common form of peripheral neuropathy, yet the mechanisms responsible for chronic pain in this disease are poorly understood. The up-regulation of the expression and function of voltage-gated sodium channel Nav1.7 has been implicated in DN, however, the exact mechanism is unclear. In the present study, we found that a proportion of streptozotocin (STZ)-treated rats suffered from mechanical allodynia and thermal hyperalgesia for a long-lasting time. Nav1.7 was up-regulated in spinal dorsal root ganglia (DRG) of rats with DN, double immunofluorescence staining showed that the increased Nav1.7 was co-localized with large and small sized neurons but not satellite glial cells. Inhibiting the synthesis of tumor necrosis factor-α (TNF-α) by thalidomide prevented DN, accompanied by strongly blocking the up-regulation of Nav1.7, TNF-α and p-nucleus factor-kappa B (p-NF-κB) in DRG. Intrathecal injection of NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly attenuated the pain behaviors and over-expression of Nav1.7 in DRG neurons. These data suggest that increased TNF-α may be responsible for up-regulation of Nav1.7 in DRG neurons of rats with DN, and NF-κB signal pathway is involved in this process. The findings might provide potential target for preventing diabetic neuropathy.

  11. A new role for AMP-activated protein kinase in the circadian regulation of L-type voltage-gated calcium channels in late-stage embryonic retinal photoreceptors.

    Huang, Cathy C Y; Shi, Liheng; Lin, Chia-Hung; Kim, Andy Jeesu; Ko, Michael L; Ko, Gladys Y-P


    AMP-activated protein kinase (AMPK) is a cellular energy sensor, which is activated when the intracellular ATP production decreases. The activities of AMPK display circadian rhythms in various organs and tissues, indicating that AMPK is involved in the circadian regulation of cellular metabolism. In vertebrate retina, the circadian clocks regulate many aspects of retinal function and physiology, including light/dark adaption, but whether and how AMPK was involved in the retinal circadian rhythm was not known. We hypothesized that the activation of AMPK (measured as phosphorylated AMPK) in the retina was under circadian control, and AMPK might interact with other intracellular signaling molecules to regulate photoreceptor physiology. We combined ATP assays, western blots, immunostaining, patch-clamp recordings, and pharmacological treatments to decipher the role of AMPK in the circadian regulation of photoreceptor physiology. We found that the overall retinal ATP content displayed a diurnal rhythm that peaked at early night, which was nearly anti-phase to the diurnal and circadian rhythms of AMPK phosphorylation. AMPK was also involved in the circadian phase-dependent regulation of photoreceptor L-type voltage-gated calcium channels (L-VGCCs), the ion channel essential for sustained neurotransmitter release. The activation of AMPK dampened the L-VGCC currents at night with a corresponding decrease in protein expression of the L-VGCCα1 pore-forming subunit, while inhibition of AMPK increased the L-VGCC current during the day. AMPK appeared to be upstream of extracellular-signal-regulated kinase and mammalian/mechanistic target of rapamycin complex 1 (mTORC1) but downstream of adenylyl cyclase in regulating the circadian rhythm of L-VGCCs. Hence, as a cellular energy sensor, AMPK integrates into the cell signaling network to regulate the circadian rhythm of photoreceptor physiology. We found that in chicken embryonic retina, the activation of AMP-activated protein

  12. A battery-based, low-noise voltage source

    Wagner, Anke; Sturm, Sven; Schabinger, Birgit; Blaum, Klaus; Quint, Wolfgang


    A highly stable, low-noise voltage source was designed to improve the stability of the electrode bias voltages of a Penning trap. To avoid excess noise and ground loops, the voltage source is completely independent of the public electric network and uses a 12 V car battery to generate output voltages of ±15 and ±5 V. First, the dc supply voltage is converted into ac-voltage and gets amplified. Afterwards, the signal is rectified, filtered, and regulated to the desired output value. Each channel can deliver up to 1.5 A. The current as well as the battery voltage and the output voltages can be read out via a universal serial bus (USB) connection for monitoring purposes. With the presented design, a relative voltage stability of 7×10-7 over 6.5 h and a noise level equal or smaller than 30 nV/√Hz is achieved.

  13. 400 V Equipment and Experiments with Capacitor Var Compensation of Thyristor Series Voltage Regulation%400V晶闸管串联调压电容无功补偿装置及试验

    王民慧; 李民族; 王武; 王世蓉


    The prototype of 400 V small capacity equipment is built and the tests are done on this equipment betore thyristor controlled reactance series compensation by adjustable coupling being put into practical application.The primary wiring device and the control and protection device with real function is developed.The steady-state parameters changes of corresponding voltage and current are tested during regulating process. The dynamic curves of thyristor current and compensation current are obtained when the device is switched on changing stage. Automatic voltage regulation and automatic power factor change experiments are done under large step changes.The test results show that this equipment can compensate reactive power in large scale and multi-stages with small impact current (rush current,surge current) when switched on. The time of changing stage is half cycle. It can automatically regulate voltage and power factor frequently.This equipment has full dynamic reactive power compensation function.%为使晶闸管串联调压电容无功补偿装置进入实用,对400V小容量装置样机进行了制作和试验.设计制作了一次接线装置和具有实际功能的控制保护装置;测试了升降级调节过程中有关电压、电流的稳态参数变化;测试了投入和换级操作过程中晶闸管电流和补偿电流的暂态波形;当负荷进行大幅度阶跃变化时,进行了自动调压和自动调节功率因数试验.测试和试验结果表明:装置能多级、大范围调节容性补偿无功;投入换级时冲击电流小,换级时间为0.5周波;能实现快速频繁的电压及功率因数等多种自动调节功能,完全具有动态无功补偿装置的技术性能.

  14. Coordinated Voltage Control of Active Distribution Network

    Xie Jiang


    Full Text Available This paper presents a centralized coordinated voltage control method for active distribution network to solve off-limit problem of voltage after incorporation of distributed generation (DG. The proposed method consists of two parts, it coordinated primal-dual interior point method-based voltage regulation schemes of DG reactive powers and capacitors with centralized on-load tap changer (OLTC controlling method which utilizes system’s maximum and minimum voltages, to improve the qualified rate of voltage and reduce the operation numbers of OLTC. The proposed coordination has considered the cost of capacitors. The method is tested using a radial edited IEEE-33 nodes distribution network which is modelled using MATLAB.

  15. Functional proteins involved in regulation of intracellular Ca(2+) for drug development: chronic nicotine treatment upregulates L-type high voltage-gated calcium channels.

    Katsura, Masashi; Ohkuma, Seitaro


    Neurochemical mechanisms underlying drug dependence and withdrawal syndrome remain unclear. In this review, we discuss how chronic nicotine exposure to neurons affects expression of diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide supposed to be a common substance participating drug dependence, and function of L-type high voltage-gated Ca(2+) channels (HVCCs). We also discuss the functional interaction between DBI and L-type HVCCs in nicotine dependence. Both DBI levels and [(45)Ca(2+)] influx significantly increased in the brain from mice treated with nicotine for long term, which was further enhanced after abrupt cessation of nicotine and was abolished by nicotinic acetylcholine receptor (nAChR) antagonists. Similar responses of DBI expression and L-type HVCC function were observed in cerebral cortical neurons after sustained exposure to nicotine. In addition, increased DBI expression was inhibited by antagonists of nAChR and L-type HVCCs. Sustained exposure of neurons to nicotine significantly enhanced expression of alpha(1) and alpha(2)/delta(1) subunits for L-type HVCCs and caused an increase in the B(max) value of [(3)H]verapamil binding to the particulate fractions. Therefore, it is concluded that the alterations in DBI expression is mediated via increased influx of Ca(2+) through upregulated L-type HVCCs and these neurochemical changes have a close relationship with development of nicotine dependence and/or its withdrawal syndrome.

  16. Magnolol inhibits colonic motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats.

    Zhang, Man; Zang, Kai-Hong; Luo, Jia-Lie; Leung, Fung-Ping; Huang, Yu; Lin, Cheng-Yuan; Yang, Zhi-Jun; Lu, Ai-Ping; Tang, Xu-Dong; Xu, Hong-Xi; Sung, Joseph Jao-yiu; Bian, Zhao-Xiang


    This study aimed to investigate the effect of magnolol (5,5'-diallyl-2,2'-biphenyldiol) on contraction in distal colonic segments of rats and the underlying mechanisms. Colonic segments were mounted in organ baths for isometric force measurement. Whole-cell voltage-sensitive L-type Ca(2+) currents were recorded on isolated single colonic smooth muscle cells using patch-clamp technique. The spontaneous contractions and acetylcholine (ACh)- and Bay K 8644-induced contractions were inhibited by magnolol (3-100 μM). In the presence of Bay K8644 (100 nM), magnolol (10-100 μM) inhibited the contraction induced by 10 μM ACh. By contrast, tetrodotoxin (100 nM) and Nώ-nitro-L-arginine methyl ester (L-NAME 100 μM) did not change the inhibitory effect of magnolol (10 μM). In addition, magnolol (3-100 μM) inhibited the L-type Ca(2+) currents. The present results suggest that magnolol inhibits colonic smooth muscle contraction through downregulating L-type Ca(2+) channel activity.

  17. α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease.

    Rostovtseva, Tatiana K; Gurnev, Philip A; Protchenko, Olga; Hoogerheide, David P; Yap, Thai Leong; Philpott, Caroline C; Lee, Jennifer C; Bezrukov, Sergey M


    Participation of the small, intrinsically disordered protein α-synuclein (α-syn) in Parkinson disease (PD) pathogenesis has been well documented. Although recent research demonstrates the involvement of α-syn in mitochondrial dysfunction in neurodegeneration and suggests direct interaction of α-syn with mitochondria, the molecular mechanism(s) of α-syn toxicity and its effect on neuronal mitochondria remain vague. Here we report that at nanomolar concentrations, α-syn reversibly blocks the voltage-dependent anion channel (VDAC), the major channel of the mitochondrial outer membrane that controls most of the metabolite fluxes in and out of the mitochondria. Detailed analysis of the blockage kinetics of VDAC reconstituted into planar lipid membranes suggests that α-syn is able to translocate through the channel and thus target complexes of the mitochondrial respiratory chain in the inner mitochondrial membrane. Supporting our in vitro experiments, a yeast model of PD shows that α-syn toxicity in yeast depends on VDAC. The functional interactions between VDAC and α-syn, revealed by the present study, point toward the long sought after physiological and pathophysiological roles for monomeric α-syn in PD and in other α-synucleinopathies.


    Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.


  19. Technological Aspects: High Voltage

    Faircloth, D C


    This paper covers the theory and technological aspects of high-voltage design for ion sources. Electric field strengths are critical to understanding high-voltage breakdown. The equations governing electric fields and the techniques to solve them are discussed. The fundamental physics of high-voltage breakdown and electrical discharges are outlined. Different types of electrical discharges are catalogued and their behaviour in environments ranging from air to vacuum are detailed. The importance of surfaces is discussed. The principles of designing electrodes and insulators are introduced. The use of high-voltage platforms and their relation to system design are discussed. The use of commercially available high-voltage technology such as connectors, feedthroughs and cables are considered. Different power supply technologies and their procurement are briefly outlined. High-voltage safety, electric shocks and system design rules are covered.

  20. Transformerless DC-DC Converter Using Cockcroft-Walton Voltage Multiplier to Obtain High DC Voltage

    Meghana G Naik,


    Full Text Available In the present scenario the use of transformer for high voltages in converter circuit reduces the overall operating efficiency due to leakage inductance and use of transformer also increases the operational cost. . Therefore the proposed system is implemented with transformer less DC-DC converter so as to obtain high DC voltage with the use of nine stage Cockcroft-Walton (CW voltage multiplier. The proposed converter operates in CCM (continuous conduction mode, so that the converter switch stress, the switching losses are reduced. The DC voltage at the input of the proposed model is low and is boosted up by boost inductor (Ls in DC-DC converter stage and performs inverter operation. The number of stages in CW-voltage multiplier circuit is applied with low input pulsating DC (AC Voltage voltage where it is getting converted to high DC output voltage. The proposed converter switches operates at two independent frequencies, modulating (fsm andalternating (fsc frequency. The fsm operates at higher frequency of the output while the fsc operates at lower frequency of the desired output voltage ripple and the output ripples can be adjusted by the switch Sc1 and Sc2. The regulation of the output voltage is achieved by controlling the Duty ratio.The simulation is carried over by the MATLABSIMULINK.

  1. Stray voltage mitigation

    Jamali, B.; Piercy, R.; Dick, P. [Kinetrics Inc., Toronto, ON (Canada). Transmission and Distribution Technologies


    This report discussed issues related to farm stray voltage and evaluated mitigation strategies and costs for limiting voltage to farms. A 3-phase, 3-wire system with no neutral ground was used throughout North America before the 1930s. Transformers were connected phase to phase without any electrical connection between the primary and secondary sides of the transformers. Distribution voltage levels were then increased and multi-grounded neutral wires were added. The earth now forms a parallel return path for the neutral current that allows part of the neutral current to flow continuously through the earth. The arrangement is responsible for causing stray voltage. Stray voltage causes uneven milk production, increased incidences of mastitis, and can create a reluctance to drink water amongst cows when stray voltages are present. Off-farm sources of stray voltage include phase unbalances, undersized neutral wire, and high resistance splices on the neutral wire. Mitigation strategies for reducing stray voltage include phase balancing; conversion from single to 3-phase; increasing distribution voltage levels, and changing pole configurations. 22 refs., 5 tabs., 13 figs.

  2. High voltage engineering

    Rizk, Farouk AM


    Inspired by a new revival of worldwide interest in extra-high-voltage (EHV) and ultra-high-voltage (UHV) transmission, High Voltage Engineering merges the latest research with the extensive experience of the best in the field to deliver a comprehensive treatment of electrical insulation systems for the next generation of utility engineers and electric power professionals. The book offers extensive coverage of the physical basis of high-voltage engineering, from insulation stress and strength to lightning attachment and protection and beyond. Presenting information critical to the design, selec

  3. High voltage test techniques

    Kind, Dieter


    The second edition of High Voltage Test Techniques has been completely revised. The present revision takes into account the latest international developments in High Voltage and Measurement technology, making it an essential reference for engineers in the testing field.High Voltage Technology belongs to the traditional area of Electrical Engineering. However, this is not to say that the area has stood still. New insulating materials, computing methods and voltage levels repeatedly pose new problems or open up methods of solution; electromagnetic compatibility (EMC) or components and systems al

  4. Mitigation of Unbalanced Voltage Sags and Voltage Unbalance in CIGRE Low Voltage Distribution Network

    Mustafa, Ghullam; Bak-Jensen, Birgitte; Mahat, Pukar; Cecati, Carlo


    Any problem with voltage in a power network is undesirable as it aggravates the quality of the power. Power electronic devices such as Voltage Source Converter (VSC) based Static Synchronous Compensator (STATCOM) etc. can be used to mitigate the voltage problems in the distribution system. The voltage problems dealt with in this paper are to show how to mitigate unbalanced voltage sags and voltage unbalance in the CIGRE Low Voltage (LV) test network and net-works like this. The voltage unbala...

  5. Voltage-gated Proton Channels

    DeCoursey, Thomas E.


    Voltage-gated proton channels, HV1, have vaulted from the realm of the esoteric into the forefront of a central question facing ion channel biophysicists, namely the mechanism by which voltage-dependent gating occurs. This transformation is the result of several factors. Identification of the gene in 2006 revealed that proton channels are homologues of the voltage-sensing domain of most other voltage-gated ion channels. Unique, or at least eccentric, properties of proton channels include dimeric architecture with dual conduction pathways, perfect proton selectivity, a single-channel conductance ~103 smaller than most ion channels, voltage-dependent gating that is strongly modulated by the pH gradient, ΔpH, and potent inhibition by Zn2+ (in many species) but an absence of other potent inhibitors. The recent identification of HV1 in three unicellular marine plankton species has dramatically expanded the phylogenetic family tree. Interest in proton channels in their own right has increased as important physiological roles have been identified in many cells. Proton channels trigger the bioluminescent flash of dinoflagellates, facilitate calcification by coccolithophores, regulate pH-dependent processes in eggs and sperm during fertilization, secrete acid to control the pH of airway fluids, facilitate histamine secretion by basophils, and play a signaling role in facilitating B-cell receptor mediated responses in B lymphocytes. The most elaborate and best-established functions occur in phagocytes, where proton channels optimize the activity of NADPH oxidase, an important producer of reactive oxygen species. Proton efflux mediated by HV1 balances the charge translocated across the membrane by electrons through NADPH oxidase, minimizes changes in cytoplasmic and phagosomal pH, limits osmotic swelling of the phagosome, and provides substrate H+ for the production of H2O2 and HOCl, reactive oxygen species crucial to killing pathogens. PMID:23798303

  6. Analysis and Design of a High-Stability,High-Accuracy,Low-Dropout Voltage Regulator%一种高稳定性高精度低压差线性稳压器的分析与设计

    沈良国; 严祖树; 王钊; 张兴; 赵元富


    A high-accuracy,low-dropout (LDO) voltage regulator is presented.Using the slow-rolloff frequency compensation scheme,the LDO effectively overcomes the stability problem,facilitates the use of a ceramic capacitor,and improves the output voltage accuracy,which is critical for powering high-performance analog circuitry.The slow-rolloff compensation scheme is realized by introducing three pole-zero pairs,including the proposed pole-zero pair and sense zero.The post-layout simulation results demonstrate that this LDO has robust system stability,a high open-loop gain,and a high unit-gain frequency,which lead to excellent regulation and transient response performance.The line and load regulation are 27μV/V and 3.78μV/mA,and the overshoots of the output voltage are less than 30mV,while the dropout voltage is 120mV for a 150mA load current.%提出了LDO,其基于缓慢滚降式频率补偿方法,通过在电路中引入三个极零对(极零对的产生没有增加静态功耗),不仅克服了常规LDO不能使用低等效串联电阻、低成本陶瓷输出电容的缺点,而且确保了系统在整个负载和输入电压变化范围内稳定工作.由于LDO通常给高性能模拟电路供电,因此其输出电压精度至关重要;而该补偿方法能满足高环路增益、高单位增益带宽的设计要求,从而大幅提高LDO的精度.该LDO基于0.5μm CMOS工艺实现.后仿结果表明,即使在低压满负载条件下,其开环DC增益仍高于70dB,满载时单位增益带宽可达3MHz,线性调整率和负载调整率分别为27μV/V和3.78μV/mA,过冲和欠冲电压均小于30mV,负载电流为150mA时的漏失电压(dropout电压)仅为120mV.

  7. A new functional role for mechanistic/mammalian target of rapamycin complex 1 (mTORC1 in the circadian regulation of L-type voltage-gated calcium channels in avian cone photoreceptors.

    Cathy Chia-Yu Huang

    Full Text Available In the retina, the L-type voltage-gated calcium channels (L-VGCCs are responsible for neurotransmitter release from photoreceptors and are under circadian regulation. Both the current densities and protein expression of L-VGCCs are significantly higher at night than during the day. However, the underlying mechanisms of circadian regulation of L-VGCCs in the retina are not completely understood. In this study, we demonstrated that the mechanistic/mammalian target of rapamycin complex (mTORC signaling pathway participated in the circadian phase-dependent modulation of L-VGCCs. The activities of the mTOR cascade, from mTORC1 to its downstream targets, displayed circadian oscillations throughout the course of a day. Disruption of mTORC1 signaling dampened the L-VGCC current densities, as well as the protein expression of L-VGCCs at night. The decrease of L-VGCCs at night by mTORC1 inhibition was in part due to a reduction of L-VGCCα1 subunit translocation from the cytosol to the plasma membrane. Finally, we showed that mTORC1 was downstream of the phosphatidylionositol 3 kinase-protein kinase B (PI3K-AKT signaling pathway. Taken together, mTORC1 signaling played a role in the circadian regulation of L-VGCCs, in part through regulation of ion channel trafficking and translocation, which brings to light a new functional role for mTORC1: the modulation of ion channel activities.

  8. Voltage verification unit

    Martin, Edward J.


    A voltage verification unit and method for determining the absence of potentially dangerous potentials within a power supply enclosure without Mode 2 work is disclosed. With this device and method, a qualified worker, following a relatively simple protocol that involves a function test (hot, cold, hot) of the voltage verification unit before Lock Out/Tag Out and, and once the Lock Out/Tag Out is completed, testing or "trying" by simply reading a display on the voltage verification unit can be accomplished without exposure of the operator to the interior of the voltage supply enclosure. According to a preferred embodiment, the voltage verification unit includes test leads to allow diagnostics with other meters, without the necessity of accessing potentially dangerous bus bars or the like.

  9. Voltage Support from Electric Vehicles in Distribution Grid

    Huang, Shaojun; Pillai, Jayakrishnan Radhakrishna; Bak-Jensen, Birgitte


    , the combination of these two methods is also examined for controlled EV charging. Simulation results show that the combination of the two individual supporting methods has the best performance in terms of voltage regulation as well as improving EV penetration level at weak distribution grids.......The paper evaluates the voltage support functions from electric vehicles (EVs) on a typical Danish distribution grid with high EV penetration. In addition to the popular voltage control modes, such as voltage droop charging (low voltage level leads to low charging power) and reactive power support...

  10. Voltage control of DC islanded microgrids

    Tucci, Michele; Riverso, Stefano; Quintero, Juan Carlos Vasquez


    We propose a new decentralized control scheme for DC Islanded microGrids (ImGs) composed by several Distributed Generation Units (DGUs) with a general interconnection topology. Each local controller regulates to a reference value the voltage of the Point of Common Coupling (PCC) of the correspond......We propose a new decentralized control scheme for DC Islanded microGrids (ImGs) composed by several Distributed Generation Units (DGUs) with a general interconnection topology. Each local controller regulates to a reference value the voltage of the Point of Common Coupling (PCC...

  11. Effect of down-regulation of voltage-gated sodium channel Nav1.7 on activation of astrocytes and microglia in DRG in rats with cancer pain

    Jun Pan; Xiang-Jin Lin; Zhi-Heng Ling; You-Zhi Cai


    Objective:To evaluate the effect of down-regulation of Nav1.7 on the activation of astrocytes and microglia in DRG of rats with cancer pain, and explore the transmission of the nociceptive information.Methods:Lentiviral vector harboring RNAi sequence targeting theNav1.7gene was constructed, and Walker 256 breast cancer cell and morphine was injected to build the bone cancer pain model and morphine tolerance model in rats. Lentiviral vector was injected. Rats in each model were divided into 4 groups: model group, PBS group, vehicle group and LV-Nav1.7 group. The expression levels of GFAP and OX42 in dorsal root ganglia (DRG) were measured.Results: After the animal model was built,the level of Nav1.7, GFAP and OX42 was improved obviously with the time prolonged, which was statistically significant (P<0.05). The expression level of GFAP and OX42 in the DRG in the LV-Nav1.7 group declined obviously compared to the model group, PBS group and vehicle group (P<0.05).Conclusions:Intrathecal injection of Navl.7 shRNA lentiviral vector can reduce the expression of Nav1.7 and inhibit the activation of astrocytes and microglia in DRG. The effort is also effective in morphine tolerance bone cancer pain model rats.

  12. Effects of ethanol on voltage-sensitive Na-channels in cultured skeletal muscle: Up-regulation as a result of chronic treatment

    Brodie, C.; Sampson, S.R. (Bar-Ilan Univ., Ramat-Gan (Israel))


    The effects of acute and chronic treatment with ethanol were studied on the number and activity of tetrodotoxin-sensitive Na-channels in cultured rat skeletal muscle. The number of channels was determined by measurements of specific binding of (3H) saxitoxin (STX) in whole cell preparations. Measurements were also made of the frequency and rate of rise of spontaneously occurring action potentials, which are the physiologic expression of Na-channel density. Acute ethanol (37.5-150 mM), while causing depolarization of membrane potential and blockade of electrical activity, was without effect on specific STX binding. Neither methanol, acetaldehyde nor ethylene glycol had significant effects on these properties when given acutely in the same concentrations as ethanol. Chronic ethanol caused dose-related increases in STX binding and action potential properties with maximal levels being attained after 3 days of treatment at a concentration of 150 mM. On removal of ethanol from the culture medium all properties returned to control levels after 48 hr. Both increased external K+ and tetrodotoxin, which up-regulate Na-channels by reducing cytosolic Ca++, potentiated the ethanol-induced increase in Na-channel density. The increase in STX binding was not associated with changes in affinity of the binding sites for the ligand but was completely prevented by treatment with cycloheximide and actinomycin D. The results demonstrate that ethanol interacts with the cell membrane to induce synthesis of STX-binding sites.


    吴大胜; 刘娜; 宫小文; 宋永光


    Objective: To evaluate the clinical effects of percutaneous puncture manual voltage regulation pulsed radiofrequency mode on the treatment cervical disc herniation. Methods: From August 2010 to September 2011, 112 patients with cervical disc herniation were given with percutaneous puncture manual voltage regulation pulsed radiofrequency mode guided through C arm X-ray machine, CT or DSA. The visual analogue scale (VAS) score and clinical effects were recorded before and after treatment. Results: After 3 d the treatment, the excellent cases were 96, the good cases were 14, and the bad cases were 2, the excellent and good rate was 98.2%. There were 2 bad cases because the doctor failed to grasp the good indication. Compared with pre-operation (7.8 ± 0.4), the VAS at 3 d after operation (1.5 ± 0.3) was decreased (P < 0.05). Conclusion: Percutaneous puncture manual voltage regulation pulsed radiofrequency mode therapy is a suitable treatment for cervical disc herniation, with the advantages of simple operation, easy to master, small trauma, not influencing the stability of spine biomechanics, no serious complications.%目的:评估手动调压脉冲射频模式治疗颈椎间盘突出症的临床可行性.方法:2010年8月~2011年9月,112例颈椎间盘突出症患者,在C型臂X线机、CT或DSA引导下接受经皮穿刺手动调压脉冲射频模式治疗.观察并记录术前后的视觉模拟评分(visual analogue scale,VAS),并进行疗效评估.结果:本组112例患者,经过该技术治疗后3d,其中96例治疗效果达优级,14例治疗效果良好,2例效果差,优良率98.2%.其中,效果较差的2例是因为未把握好适应症.与术前VAS评分(7.8±0.4)相比,术后3天VAS评分(1.5±0.3)降低(P<0.05).结论:经皮穿刺手动调压脉冲射频模式治疗颈椎间盘突出症具有操作简单、易于掌握、创伤小、不影响脊柱生物力学稳定性、无严重并发症等特点.是一种可供临床选用的、效果确切又较

  14. Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels.

    Garza-López, Edgar; Sandoval, Alejandro; González-Ramírez, Ricardo; Gandini, María A; Van den Maagdenberg, Arn; De Waard, Michel; Felix, Ricardo


    Familial hemiplegic migraine type 1 (FHM-1) is a monogenic form of migraine with aura that is characterized by recurrent attacks of a typical migraine headache with transient hemiparesis during the aura phase. In a subset of patients, additional symptoms such as epilepsy and cerebellar ataxia are part of the clinical phenotype. FHM-1 is caused by missense mutations in the CACNA1A gene that encodes the pore-forming subunit of Ca(V)2.1 voltage-gated Ca(2+) channels. Although the functional effects of an increasing number of FHM-1 mutations have been characterized, knowledge on the influence of most of these mutations on G protein regulation of channel function is lacking. Here, we explored the effects of G protein-dependent modulation on mutations W1684R and V1696I which cause FHM-1 with and without cerebellar ataxia, respectively. Both mutations were introduced into the human Ca(V)2.1α(1) subunit and their functional consequences investigated after heterologous expression in human embryonic kidney 293 (HEK-293) cells using patch-clamp recordings. When co-expressed along with the human μ-opioid receptor, application of the agonist [d-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) inhibited currents through both wild-type (WT) and mutant Ca(V)2.1 channels, which is consistent with the known modulation of these channels by G protein-coupled receptors. Prepulse facilitation, which is a way to characterize the relief of direct voltage-dependent G protein regulation, was reduced by both FHM-1 mutations. Moreover, the kinetic analysis of the onset and decay of facilitation showed that the W1684R and V1696I mutations affect the apparent dissociation and reassociation rates of the Gβγ dimer from the channel complex, suggesting that the G protein-Ca(2+) channel affinity may be altered by the mutations. These biophysical studies may shed new light on the pathophysiology underlying FHM-1.

  15. High Voltage Distribution

    Norbeck, Edwin; Miller, Michael; Onel, Yasar


    For detector arrays that require 5 to 10 kV at a few microamps each for hundreds of detectors, using hundreds of HV power supplies is unreasonable. Bundles of hundreds of HV cables take up space that should be filled with detectors. A typical HV module can supply 1 ma, enough current for hundreds of detectors. It is better to use a single HV module and distribute the current as needed. We show a circuit that, for each detector, measures the current, cuts off the voltage if the current exceeds a set maximum, and allows the HV to be turned on or off from a control computer. The entire array requires a single HV cable and 2 or 3 control lines. This design provides the same voltage to all of the detectors, the voltage set by the single HV module. Some additional circuitry would allow a computer controlled voltage drop between the HV and each individual detector.

  16. High voltage engineering fundamentals

    Kuffel, E; Hammond, P


    Provides a comprehensive treatment of high voltage engineering fundamentals at the introductory and intermediate levels. It covers: techniques used for generation and measurement of high direct, alternating and surge voltages for general application in industrial testing and selected special examples found in basic research; analytical and numerical calculation of electrostatic fields in simple practical insulation system; basic ionisation and decay processes in gases and breakdown mechanisms of gaseous, liquid and solid dielectrics; partial discharges and modern discharge detectors; and over

  17. Low-voltage gyrotrons

    Glyavin, M. Yu.; Zavolskiy, N. A.; Sedov, A. S.; Nusinovich, G. S.


    For a long time, the gyrotrons were primarily developed for electron cyclotron heating and current drive of plasmas in controlled fusion reactors where a multi-megawatt, quasi-continuous millimeter-wave power is required. In addition to this important application, there are other applications (and their number increases with time) which do not require a very high power level, but such issues as the ability to operate at low voltages and have compact devices are very important. For example, gyrotrons are of interest for a dynamic nuclear polarization, which improves the sensitivity of the nuclear magnetic resonance spectroscopy. In this paper, some issues important for operation of gyrotrons driven by low-voltage electron beams are analyzed. An emphasis is made on the efficiency of low-voltage gyrotron operation at the fundamental and higher cyclotron harmonics. These efficiencies calculated with the account for ohmic losses were, first, determined in the framework of the generalized gyrotron theory based on the cold-cavity approximation. Then, more accurate, self-consistent calculations for the fundamental and second harmonic low-voltage sub-THz gyrotron designs were carried out. Results of these calculations are presented and discussed. It is shown that operation of the fundamental and second harmonic gyrotrons with noticeable efficiencies is possible even at voltages as low as 5-10 kV. Even the third harmonic gyrotrons can operate at voltages about 15 kV, albeit with rather low efficiency (1%-2% in the submillimeter wavelength region).

  18. Unified Power Quality Conditioner for voltage and current compensation



    Full Text Available This paper deals with a Unified Power Quality Conditioner (UPQC for load balancing, power factorcorrection, voltage regulation, voltage and current harmonics mitigation, mitigation of voltage sag, swelland voltage dip in a three-phase three-wire distribution system for different combinations of linear and nonlinear loads.The unified power quality conditioner (UPQC is a combination of back to back connected shunt and series active power filters (APFs to a common DC link voltage, which compensates voltage and current based distortions, independently.Using instantaneous active and reactive Power theory ,harmonic detection, reactive power compensation, voltage sag and swell have been simulated and the results are analyzed. The operation and capability of the proposed system was analyzed through simulations with MATLAB / SIMULINK.

  19. 感应电动机交流相控调压下的损耗分析%Loss Analysis on the Induction Motor Under Phase-control AC Voltage Regulation



    The dynamic mathematic model based upon space vector coordinate system was established to study the change of energy loss of the induction motor under phase-control AC voltage regulation. Change intension of various loss of the motor under different firing angle was achieved by means of MATLAB simulation, especially the copper loss of the stator and rotor as well as the iron loss. Data of experiments verified correctness of the simulation results.%建立基于空间矢量坐标系的动态数学模型,研究相控调压技术下感应电机的能耗变化。并通过MATLAB仿真得到电机在不同触发角下的各项损耗变化趋势,特别是定、转子铜损耗和铁损耗。实验数据验证了仿真结果的正确性。

  20. The Voltage-Dependent Anion Channel 1 (AtVDAC1 Negatively Regulates Plant Cold Responses during Germination and Seedling Development in Arabidopsis and Interacts with Calcium Sensor CBL1

    Zhi-Yong Li


    Full Text Available The voltage-dependent anion channel (VDAC, a highly conserved major mitochondrial outer membrane protein, plays crucial roles in energy metabolism and metabolite transport. However, knowledge about the roles of the VDAC family in plants is limited. In this study, we investigated the expression pattern of VDAC1 in Arabidopsis and found that cold stress promoted the accumulation of VDAC1 transcripts in imbibed seeds and mature plants. Overexpression of VDAC1 reduced tolerance to cold stress in Arabidopsis. Phenotype analysis of VDAC1 T-DNA insertion mutant plants indicated that a vdac1 mutant line had faster germination kinetics under cold treatment and showed enhanced tolerance to freezing. The yeast two-hybrid system revealed that VDAC1 interacts with CBL1, a calcium sensor in plants. Like the vdac1, a cbl1 mutant also exhibited a higher seed germination rate. We conclude that both VDAC1 and CBL1 regulate cold stress responses during seed germination and plant development.

  1. Device for monitoring cell voltage

    Doepke, Matthias [Garbsen, DE; Eisermann, Henning [Edermissen, DE


    A device for monitoring a rechargeable battery having a number of electrically connected cells includes at least one current interruption switch for interrupting current flowing through at least one associated cell and a plurality of monitoring units for detecting cell voltage. Each monitoring unit is associated with a single cell and includes a reference voltage unit for producing a defined reference threshold voltage and a voltage comparison unit for comparing the reference threshold voltage with a partial cell voltage of the associated cell. The reference voltage unit is electrically supplied from the cell voltage of the associated cell. The voltage comparison unit is coupled to the at least one current interruption switch for interrupting the current of at least the current flowing through the associated cell, with a defined minimum difference between the reference threshold voltage and the partial cell voltage.

  2. High voltage pulse generator

    Fasching, George E.


    An improved high-voltage pulse generator has been provided which is especially useful in ultrasonic testing of rock core samples. An N number of capacitors are charged in parallel to V volts and at the proper instance are coupled in series to produce a high-voltage pulse of N times V volts. Rapid switching of the capacitors from the paralleled charging configuration to the series discharging configuration is accomplished by using silicon-controlled rectifiers which are chain self-triggered following the initial triggering of a first one of the rectifiers connected between the first and second of the plurality of charging capacitors. A timing and triggering circuit is provided to properly synchronize triggering pulses to the first SCR at a time when the charging voltage is not being applied to the parallel-connected charging capacitors. Alternate circuits are provided for controlling the application of the charging voltage from a charging circuit to be applied to the parallel capacitors which provides a selection of at least two different intervals in which the charging voltage is turned "off" to allow the SCR's connecting the capacitors in series to turn "off" before recharging begins. The high-voltage pulse-generating circuit including the N capacitors and corresponding SCR's which connect the capacitors in series when triggered "on" further includes diodes and series-connected inductors between the parallel-connected charging capacitors which allow sufficiently fast charging of the capacitors for a high pulse repetition rate and yet allow considerable control of the decay time of the high-voltage pulses from the pulse-generating circuit.

  3. VKCDB: Voltage-gated potassium channel database

    Gallin Warren J


    Full Text Available Abstract Background The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical physiological processes. VKCDB (Voltage-gated potassium [K] Channel DataBase is a database of structural and functional data on these channels. It is designed as a resource for research on the molecular basis of voltage-gated potassium channel function. Description Voltage-gated potassium channel sequences were identified by using BLASTP to search GENBANK and SWISSPROT. Annotations for all voltage-gated potassium channels were selectively parsed and integrated into VKCDB. Electrophysiological and pharmacological data for the channels were collected from published journal articles. Transmembrane domain predictions by TMHMM and PHD are included for each VKCDB entry. Multiple sequence alignments of conserved domains of channels of the four Kv families and the KCNQ family are also included. Currently VKCDB contains 346 channel entries. It can be browsed and searched using a set of functionally relevant categories. Protein sequences can also be searched using a local BLAST engine. Conclusions VKCDB is a resource for comparative studies of voltage-gated potassium channels. The methods used to construct VKCDB are general; they can be used to create specialized databases for other protein families. VKCDB is accessible at

  4. Virtual Admittance Loop for Voltage Harmonic Compensation in Microgrids

    Blanco, Cristian; Reigosa, David; Quintero, Juan Carlos Vasquez


    is that it can only be applied to distributed generation (DG) units operating in voltage control mode (VSI-VCM), but is not applicable to DG units working in current control mode (e.g. current regulated voltage source inverters, VSI-CCM). Contrary to this, the proposed method can be used in any converter...

  5. Virtual admittance loop for voltage harmonic compensation in microgrids

    Blanco, Cristian; Reigosa, David; Quintero, Juan Carlos Vasquez


    is that it can only be applied to distributed generation (DG) units operating in voltage control mode (VSI-VCM), but is not applicable to DG units working in current control mode (e.g. current regulated voltage source inverters, VSI-CCM or current source inverters, CSIs. Contrary to this, the proposed method can...

  6. Studying Voltage Transformer Ferroresonance

    Hamid Radmanesh


    Full Text Available This study studies the effect of Circuit Breaker Shunt Resistance (CBSR, Metal Oxide Vaistor (MOV and Neutral earth Resistance (NR on the control of ferroresonance in the voltage transformer. It is expected that NR can controlled ferroresonance better than MOV and CBSR. Study has been done on a one phase voltage transformer rated 100 VA, 275 kV. The simulation results reveal that considering the CBSR and MOV exhibits a great mitigating effect on ferroresonance overvoltages, but these resistances cannot control these phenomena for all range of parameters. By applying NR to the system structure, ferroresonance has been controlled and its amplitude has been damped for all parameters values.

  7. Geomagnetism and Induced Voltage

    Abdul-Razzaq, W.; Biller, R. D.


    Introductory physics laboratories have seen an influx of "conceptual integrated science" over time in their classrooms with elements of other sciences such as chemistry, biology, Earth science, and astronomy. We describe a laboratory to introduce this development, as it attracts attention to the voltage induced in the human brain as it…

  8. High-voltage picoamperemeter

    Bugl, Andrea; Ball, Markus; Boehmer, Michael; Doerheim, Sverre; Hoenle, Andreas; Konorov, Igor [Technische Universitaet Muenchen, Garching (Germany); Ketzer, Bernhard [Technische Universitaet Muenchen, Garching (Germany); Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany)


    Current measurements in the nano- and picoampere region on high voltage are an important tool to understand charge transfer processes in micropattern gas detectors like the Gas Electron Multiplier (GEM). They are currently used to e.g. optimize the field configuration in a multi-GEM stack to be used in the ALICE TPC after the upgrade of the experiment during the 2nd long shutdown of the LHC. Devices which allow measurements down to 1pA at high voltage up to 6 kV have been developed at TU Muenchen. They are based on analog current measurements via the voltage drop over a switchable shunt. A microcontroller collects 128 digital ADC values and calculates their mean and standard deviation. This information is sent with a wireless transmitting unit to a computer and stored in a root file. A nearly unlimited number of devices can be operated simultaneously and read out by a single receiver. The results can also be displayed on a LCD directly at the device. Battery operation and the wireless readout are important to protect the user from any contact to high voltage. The principle of the device is explained, and systematic studies of their properties are shown.

  9. 基于电力电子调压电路的直流不停电融冰技术%Study of DC Ice-melting Without Power Cut Technology Based on Power Electronic Voltage-regulating Circuits

    宋洁莹; 周飞; 拜润清; 蔡林海; 荆平


    Ice-coating of transmission lines every year in winter seriously affects reliable operation of power grids in China. Present electrical ice-melting methods all require power interruption, which brings negative effects to power grid. To address this issue, principles and feasibility of DC and AC ice-melting without power cut methods are analyzed, a new DC ice-melting without power cut method is proposed, and its circuit structure and capacity requirements are analyzed. At last, a model of the ice-melting device under PSCAD is built and its principles and functions are verified by simulation. The DC ice-melting without power cut device based on power electronic voltage-regulating circuits has high working efficiency and little influence upon regular power supplying.%我国冬季出现的输电线路覆冰的情况严重影响电力系统的可靠运行,现有的电力融冰均需停电进行,对系统影响较大。针对这个问题,分析交、直流不停电融冰的原理及可行性,提出一种新型的不停电直流融冰方法,对其电路结构和所需容量进行分析,并建立不停电融冰装置仿真模型,进行原理和功能验证。基于电力电子调压电路的不停电直流融冰装置具有融冰效率高且不影响线路供电的优点。

  10. Performance Characteristics of an Armature Voltage Controlled D.C. ...

    Performance Characteristics of an Armature Voltage Controlled D.C. Motor. ... the performance characteristics of a test motor are obtained by digital computer analysis. ... speed regulation and response characteristics for the d. c. drive system.

  11. Intermediate state trapping of a voltage sensor

    Lacroix, Jérôme J; Pless, Stephan Alexander; Maragliano, Luca


    Voltage sensor domains (VSDs) regulate ion channels and enzymes by undergoing conformational changes depending on membrane electrical signals. The molecular mechanisms underlying the VSD transitions are not fully understood. Here, we show that some mutations of I241 in the S1 segment of the Shaker...... Kv channel positively shift the voltage dependence of the VSD movement and alter the functional coupling between VSD and pore domains. Among the I241 mutants, I241W immobilized the VSD movement during activation and deactivation, approximately halfway between the resting and active states......, and drastically shifted the voltage activation of the ionic conductance. This phenotype, which is consistent with a stabilization of an intermediate VSD conformation by the I241W mutation, was diminished by the charge-conserving R2K mutation but not by the charge-neutralizing R2Q mutation. Interestingly, most...

  12. Automatic Voltage Control (AVC) System under Uncertainty from Wind Power

    Qin, Nan; Abildgaard, Hans; Flynn, Damian


    An automatic voltage control (AVC) system maintains the voltage profile of a power system in an acceptable range and minimizes the operational cost by coordinating the regulation of controllable components. Typically, all of the parameters in the optimization problem are assumed to be certain...... and constant in the decision making process. However, for high shares of wind power, uncertainty in the decision process due to wind power variability may result in an infeasible AVC solution. This paper proposes a voltage control approach which considers the voltage uncertainty from wind power productions....... The proposed method improves the performance and the robustness of a scenario based approach by estimating the potential voltage variations due to fluctuating wind power production, and introduces a voltage margin to protect the decision against uncertainty for each scenario. The effectiveness of the proposed...

  13. Proposal for voltage regulation in an induction generator with self-excited rotor coupled to a system of wind power energy capitation; Proposta de regulacao de tensao para um gerador de inducao com rotor em gaiola de esquilo acoplada a um sistema de captacao de energia eolica

    Nunes, Marcus V.; Bezerra, Ubiratan H. [Para Univ., Belem, PA (Brazil). Dept. de Engenharia Eletrica


    It is proposed in this paper the use of a series capacitor bank to regulate the terminal voltage of an induction generator which may be coupled to a wind turbine of the type variable - speed - and variable - frequency to generate electric power. The proposed system may be an attractive alternative to the thyristor controlled systems. The system proposed here consists of a shunt capacitor bank which is responsible to self-excite the induction machine and a series capacitor bank to regulate the machine terminal voltage. The Newton - Raphson iterative method was used to analyze the performance of the self-excited induction machine with series capacitive compensation proposed in this paper, demonstrating good convergence characteristics in all cases simulated. (author) 8 refs., 9 figs.; e-mail: marcus at

  14. Analyzing of Dynamic Voltage Restorer in Series Compensation Voltage

    Naser Parhizgar


    Full Text Available The Dynamic Voltage Restorer (DVR is a series-connected compensator to generate a controllable voltage to against the short-term voltage disturbances. The technique of DVR is an effective and cost competitive approach to improve voltage quality at the load side. This study presents a single-phase and threephase DVR system with reduced switch-count topology to protect the sensitive load against abnormal voltage conditions. Most basic function, the DVR configuration consist of a two level Voltage Source Converter (VSC, a dc energy storage device, a coupling transformer Connected in shunt with the ac system This study presents the application of Dynamic Voltage Restorer (DVR on power distribution systems for mitigation of voltage sag at critical loads. DVR is one of the compensating types of custom power devices. The DVR, which is based on forced-commutated Voltage Source Converter (VSC has been proved suitable for the task of compensating voltage sags/swells. Simulation results are presented to illustrate and understand the performances of DVR in supporting load voltages under voltage sags/swells conditions.

  15. High Voltage Charge Pump

    Emira, Ahmed A.


    Various embodiments of a high voltage charge pump are described. One embodiment is a charge pump circuit that comprises a plurality of switching stages each including a clock input, a clock input inverse, a clock output, and a clock output inverse. The circuit further comprises a plurality of pumping capacitors, wherein one or more pumping capacitors are coupled to a corresponding switching stage. The circuit also comprises a maximum selection circuit coupled to a last switching stage among the plurality of switching stages, the maximum selection circuit configured to filter noise on the output clock and the output clock inverse of the last switching stage, the maximum selection circuit further configured to generate a DC output voltage based on the output clock and the output clock inverse of the last switching stage.

  16. High voltage systems (tube-type microwave)/low voltage system (solid-state microwave) power distribution

    Nussberger, A. A.; Woodcock, G. R.


    SPS satellite power distribution systems are described. The reference Satellite Power System (SPS) concept utilizes high-voltage klystrons to convert the onboard satellite power from dc to RF for transmission to the ground receiving station. The solar array generates this required high voltage and the power is delivered to the klystrons through a power distribution subsystem. An array switching of solar cell submodules is used to maintain bus voltage regulation. Individual klystron dc voltage conversion is performed by centralized converters. The on-board data processing system performs the necessary switching of submodules to maintain voltage regulation. Electrical power output from the solar panels is fed via switch gears into feeder buses and then into main distribution buses to the antenna. Power also is distributed to batteries so that critical functions can be provided through solar eclipses.

  17. Increased voltage photovoltaic cell

    Ross, B.; Bickler, D. B.; Gallagher, B. D. (Inventor)


    A photovoltaic cell, such as a solar cell, is provided which has a higher output voltage than prior cells. The improved cell includes a substrate of doped silicon, a first layer of silicon disposed on the substrate and having opposite doping, and a second layer of silicon carbide disposed on the first layer. The silicon carbide preferably has the same type of doping as the first layer.

  18. High Voltage Seismic Generator

    Bogacz, Adrian; Pala, Damian; Knafel, Marcin


    This contribution describes the preliminary result of annual cooperation of three student research groups from AGH UST in Krakow, Poland. The aim of this cooperation was to develop and construct a high voltage seismic wave generator. Constructed device uses a high-energy electrical discharge to generate seismic wave in ground. This type of device can be applied in several different methods of seismic measurement, but because of its limited power it is mainly dedicated for engineering geophysics. The source operates on a basic physical principles. The energy is stored in capacitor bank, which is charged by two stage low to high voltage converter. Stored energy is then released in very short time through high voltage thyristor in spark gap. The whole appliance is powered from li-ion battery and controlled by ATmega microcontroller. It is possible to construct larger and more powerful device. In this contribution the structure of device with technical specifications is resented. As a part of the investigation the prototype was built and series of experiments conducted. System parameter was measured, on this basis specification of elements for the final device were chosen. First stage of the project was successful. It was possible to efficiently generate seismic waves with constructed device. Then the field test was conducted. Spark gap wasplaced in shallowborehole(0.5 m) filled with salt water. Geophones were placed on the ground in straight line. The comparison of signal registered with hammer source and sparker source was made. The results of the test measurements are presented and discussed. Analysis of the collected data shows that characteristic of generated seismic signal is very promising, thus confirms possibility of practical application of the new high voltage generator. The biggest advantage of presented device after signal characteristics is its size which is 0.5 x 0.25 x 0.2 m and weight approximately 7 kg. This features with small li-ion battery makes

  19. Mitigation of Voltage Sags in CIGRE Low Voltage Distribution Network

    Mustafa, Ghullam; Bak-Jensen, Birgitte; Mahat, Pukar;


    problems in the distribution system. The voltage problems dealt with in this paper are to show how to mitigate voltage sags in the CIGRE Low Voltage (LV) test network and networks like this. The voltage sags, for the tested cases in the CIGRE LV test network are mainly due to three phase faults....... The compensation of voltage sags in the different parts of CIGRE distribution network is done by using the four STATCOM compensators already existing in the test grid. The simulations are carried out in DIgSILENT power factory software version 15.0....

  20. Voltage Controlled Dynamic Demand Response

    Bhattarai, Bishnu Prasad; Bak-Jensen, Birgitte; Mahat, Pukar


    . An adaptive dynamic model has been developed to determine composite voltage dependency of an aggregated load on feeder level. Following the demand dispatch or control signal, optimum voltage setting at the LV substation is determined based on the voltage dependency of the load. Furthermore, a new technique...

  1. Charge-pump voltage converter

    Brainard, John P.; Christenson, Todd R.


    A charge-pump voltage converter for converting a low voltage provided by a low-voltage source to a higher voltage. Charge is inductively generated on a transfer rotor electrode during its transit past an inductor stator electrode and subsequently transferred by the rotating rotor to a collector stator electrode for storage or use. Repetition of the charge transfer process leads to a build-up of voltage on a charge-receiving device. Connection of multiple charge-pump voltage converters in series can generate higher voltages, and connection of multiple charge-pump voltage converters in parallel can generate higher currents. Microelectromechanical (MEMS) embodiments of this invention provide a small and compact high-voltage (several hundred V) voltage source starting with a few-V initial voltage source. The microscale size of many embodiments of this invention make it ideally suited for MEMS- and other micro-applications where integration of the voltage or charge source in a small package is highly desirable.

  2. Transient voltage sharing in series-coupled high voltage switches

    Editorial Office


    Full Text Available For switching voltages in excess of the maximum blocking voltage of a switching element (for example, thyristor, MOSFET or bipolar transistor such elements are often coupled in series - and additional circuitry has to be provided to ensure equal voltage sharing. Between each such series element and system ground there is a certain parasitic capacitance that may draw a significant current during high-speed voltage transients. The "open" switch is modelled as a ladder network. Analy­sis reveals an exponential progression in the distribution of the applied voltage across the elements. Overstressing thus oc­curs in some of the elements at levels of the total voltage that are significantly below the design value. This difficulty is overcome by grading the voltage sharing circuitry, coupled in parallel with each element, in a prescribed manner, as set out here.

  3. MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction

    Xue Liu


    Full Text Available Background/Aims: Acute myocardial infarction (AMI is a devastating cardiovascular disease with a high rate of morbidity and mortality, partly due to enhanced arrhythmogenicity. MicroRNAs (miRNAs have been shown to participate in the regulation of cardiac ion channels and the associated arrhythmias. The purpose of this study was to test our hypothesis that miR-223-3p contributes to the electrical disorders in AMI via modulating KCND2, the gene encoding voltage-gated channel Kv4.2 that carries transient outward K+ current Ito. Methods: AMI model was established in male Sprague-Dawley (SD rats by left anterior descending artery (LAD ligation. Evans blue and TTC staining was used to measure infarct area. Ito was recorded in isolated ventricular cardiomyocytes or cultured neonatal rat ventricular cells (NRVCs by whole-cell patch-clamp techniques. Western blot analysis was employed to detect the protein level of Kv4.2 and real-time RT-PCR to determine the transcript level of miR-223-3p. Luciferase assay was used to examine the interaction between miR-223-3p and KCND2 in cultured NRVCs. Results: Expression of miR-223-3p was remarkably upregulated in AMI relative to sham control rats. On the contrary, the protein level of Kv4.2 and Ito density were significantly decreased in AMI. Consistently, transfection of miR-223-3p mimic markedly reduced Kv4.2 protein level and Ito current in cultured NRVCs. Co-transfection of AMO-223-3p (an antisense inhibitor of miR-223-3p reversed the repressive effect of miR-223-3p. Luciferase assay showed that miR-223-3p, but not the negative control, substantially suppressed the luciferase activity, confirming the direct binding of miR-223-3p to the seed site within the KCND2 sequence. Finally, direct intramuscular injection of AMO-223-3p into the ischemic myocardium to knockdown endogenous miR-223-3p decreased the propensity of ischemic arrhythmias. Conclusions: Upregulation of miR-223-3p in AMI repressed the expression of

  4. Distributed voltage control coordination between renewable generation plants in MV distribution grids

    Petersen, Lennart; Iov, Florin


    This study focuses on distributed voltage control coordination between renewable generation plants in medium-voltage distribution grids (DGs). A distributed offline coordination concept has been defined in a previous publication, leading to satisfactory voltage regulation in the DG. However, here...

  5. Effect of state feedback coupling on the transient performance of voltage source inverters with LC filter

    Federico, de Bosio; Pastorelli, Michele; Antonio DeSouza Ribeiro, Luiz


    State feedback coupling between the capacitor voltage and inductor current deteriorates notably the performance during transients of voltage and current regulators in stand-alone systems based on voltage source inverters. A decoupling technique is proposed, considering the limitations introduced ...... by system delays. Laboratory experiments were executed in compliance with the normative for Uninterruptible Power Supply systems to prove the developed analysis....

  6. Stability Analysis and Controller Synthesis for Single-Loop Voltage-Controlled VSIs

    Wang, Xiongfei; Loh, Poh Chiang; Blaabjerg, Frede


    This paper analyzes the stability of the digital single-loop voltage-controlled Voltage-Source Inverters (VSIs) using linear voltage regulators. It reveals that the phase lags caused by using the resonant controller and the time delay of digital control system can stabilize the voltage loop without...... damping of the LC-filter resonance. The stability region for the digital single-loop resonant voltage control is then identified considering the effects of the discretization methods applied to the resonant controller. An enhanced voltage control scheme with widened stability region is subsequently...

  7. Voltage Unbalance and Harmonic Compensation in Microgrids by Cooperation of Distributed Generators and Active Power Filters

    Hashempour, Mohammad M.; Savaghebi, Mehdi; Quintero, Juan Carlos Vasquez


    , selective virtual impedance and voltage/current regulators. Based on the secondary control, at first voltage harmonic compensation and voltage unbalance compensation of point of common coupling (PCC), that might includes sensitive loads, is carried out by DGs. Voltage compensation of PCC by DGs may cause...... severe voltage distortion at DGs terminals. Thus, the coordinated control is used to mitigate the voltage distortion to the defined maximum allowable value at DGs terminals. Evaluation of the proposed hierarchical control is carried out by a simulation study....

  8. Application of Load Compensation in Voltage Controllers of Large Generators in the Polish Power Grid

    Bogdan Sobczak


    Full Text Available The Automatic Voltage Regulator normally controls the generator stator terminal voltage. Load compensation is used to control the voltage which is representative of the voltage at a point either within or external to the generator. In the Polish Power Grid (PPG compensation is ready to use in every AVR of a large generator, but it is utilized only in the case of generators operating at the same medium voltage buses. It is similar as in most European Power Grids. The compensator regulating the voltage at a point beyond the machine terminals has significant advantages in comparison to the slower secondary Voltage and Reactive Power Control System (ARNE1. The compensation stiffens the EHV grid, which leads to improved voltage quality in the distribution grid. This effect may be particularly important in the context of the dynamic development of wind and solar energy.

  9. No-Voltage Meter


    VW- IKft, 1/4 H4 -Wv- IK!1, I/4W INTERNAL VOLTAGE NOTE ALL TRANSISTORS ARE 2N43A OR EQUIVALENT GERMANIUM ALLOY PNP AA ALKALINE BATTERY...D-,, regardless of polarity. This signal is then full-wave rectified by the diode-connected Germanium transistor bridge, T,, T-,, T3, and T4... Transistor T5 acts as a second current limiter. Resistor R2 was selected to give 90 f# of full-scale meter deflection with an input signal of 115 volts

  10. Transfer of Kv3.1 voltage sensor features to the isolated Ci-VSP voltage-sensing domain.

    Mishina, Yukiko; Mutoh, Hiroki; Knöpfel, Thomas


    Membrane proteins that respond to changes in transmembrane voltage are critical in regulating the function of living cells. The voltage-sensing domains (VSDs) of voltage-gated ion channels are extensively studied to elucidate voltage-sensing mechanisms, and yet many aspects of their structure-function relationship remain elusive. Here, we transplanted homologous amino acid motifs from the tetrameric voltage-activated potassium channel Kv3.1 to the monomeric VSD of Ciona intestinalis voltage-sensitive phosphatase (Ci-VSP) to explore which portions of Kv3.1 subunits depend on the tetrameric structure of Kv channels and which properties of Kv3.1 can be transferred to the monomeric Ci-VSP scaffold. By attaching fluorescent proteins to these chimeric VSDs, we obtained an optical readout to establish membrane trafficking and kinetics of voltage-dependent structural rearrangements. We found that motifs extending from 10 to roughly 100 amino acids can be readily transplanted from Kv3.1 into Ci-VSP to form engineered VSDs that efficiently incorporate into the plasma membrane and sense voltage. Some of the functional features of these engineered VSDs are reminiscent of Kv3.1 channels, indicating that these properties do not require interactions between Kv subunits or between the voltage sensing and the pore domains of Kv channels.

  11. Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid.

    Sakata, Souhei; Jinno, Yuka; Kawanabe, Akira; Okamura, Yasushi


    The cytoplasmic region of voltage-sensing phosphatase (VSP) derives the voltage dependence of its catalytic activity from coupling to a voltage sensor homologous to that of voltage-gated ion channels. To assess the conformational changes in the cytoplasmic region upon activation of the voltage sensor, we genetically incorporated a fluorescent unnatural amino acid, 3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid (Anap), into the catalytic region of Ciona intestinalis VSP (Ci-VSP). Measurements of Anap fluorescence under voltage clamp in Xenopus oocytes revealed that the catalytic region assumes distinct conformations dependent on the degree of voltage-sensor activation. FRET analysis showed that the catalytic region remains situated beneath the plasma membrane, irrespective of the voltage level. Moreover, Anap fluorescence from a membrane-facing loop in the C2 domain showed a pattern reflecting substrate turnover. These results indicate that the voltage sensor regulates Ci-VSP catalytic activity by causing conformational changes in the entire catalytic region, without changing their distance from the plasma membrane.

  12. Heat-pump performance: voltage dip/sag, under-voltage and over-voltage

    William J.B. Heffernan


    Full Text Available Reverse cycle air-source heat-pumps are an increasingly significant load in New Zealand and in many other countries. This has raised concern over the impact wide-spread use of heat-pumps may have on the grid. The characteristics of the loads connected to the power system are changing because of heat-pumps. Their performance during under-voltage events such as voltage dips has the potential to compound the event and possibly cause voltage collapse. In this study, results from testing six heat-pumps are presented to assess their performance at various voltages and hence their impact on voltage stability.

  13. Local Dynamic Reactive Power for Correction of System Voltage Problems

    Kueck, John D [ORNL; Rizy, D Tom [ORNL; Li, Fangxing [ORNL; Xu, Yan [ORNL; Li, Huijuan [University of Tennessee, Knoxville (UTK); Adhikari, Sarina [ORNL; Irminger, Philip [ORNL


    Distribution systems are experiencing outages due to a phenomenon known as local voltage collapse. Local voltage collapse is occurring in part because modern air conditioner compressor motors are much more susceptible to stalling during a voltage dip than older motors. These motors can stall in less than 3 cycles (.05s) when a fault, such as on the sub-transmission system, causes voltage to sag to 70 to 60%. The reasons for this susceptibility are discussed in the report. During the local voltage collapse, voltages are depressed for a period of perhaps one or two minutes. There is a concern that these local events are interacting together over larger areas and may present a challenge to system reliability. An effective method of preventing local voltage collapse is the use of voltage regulation from Distributed Energy Resources (DER) that can supply or absorb reactive power. DER, when properly controlled, can provide a rapid correction to voltage dips and prevent motor stall. This report discusses the phenomenon and causes of local voltage collapse as well as the control methodology we have developed to counter voltage sag. The problem is growing because of the use of low inertia, high efficiency air conditioner (A/C) compressor motors and because the use of electric A/C is growing in use and becoming a larger percentage of system load. A method for local dynamic voltage regulation is discussed which uses reactive power injection or absorption from local DER. This method is independent, rapid, and will not interfere with conventional utility system voltage control. The results of simulations of this method are provided. The method has also been tested at the ORNL s Distributed Energy Communications and Control (DECC) Laboratory using our research inverter and synchronous condenser. These systems at the DECC Lab are interconnected to an actual distribution system, the ORNL distribution system, which is fed from TVA s 161kV sub-transmission backbone. The test results

  14. Voltage Swells Improvement in Low Voltage Network Using Dynamic Voltage Restorer

    R. Omar


    Full Text Available Problem statement: Voltage disturbances are the most common power quality problem due to the increased use of a large numbers of sophisticated electronic equipment in industrial distribution system. The voltage disturbances such as voltage sags, swells, harmonics, unbalance and flickers. High quality in the power supply is needed, since failures due to such disturbances usually have a high impact on production cost. There are many different solutions to compensate voltage disturbances but the use of a DVR is considered to be the most cost effective method. The objective of this study is to propose a new topology of a DVR in order to mitigate voltage swells using a powerful power custom device namely the Dynamic Voltage Restorer (DVR. Approach: New configuration of a DVR with an improvement of a controller based on direct-quadrature-zero method has been introduced to compensate voltage swells in the network. Results: The effectiveness of the DVR with its controller were verify using Matlab/Simulinks SimPower Toolbox and then implemented using 5KVA DVR experimental setup. Simulations and experimental results demonstrate the effective dynamic performance of the proposed configuration. Conclusion: The implimentation of the proposed DVR validate the capabilities in mitigating of voltage swells effectiveness.During voltage swells, the DVR injects an appropriate voltage to maintain the load voltage at its nominal value.

  15. Isomerically Pure Tetramethylrhodamine Voltage Reporters.

    Deal, Parker E; Kulkarni, Rishikesh U; Al-Abdullatif, Sarah H; Miller, Evan W


    We present the design, synthesis, and application of a new family of fluorescent voltage indicators based on isomerically pure tetramethylrhodamines. These new Rhodamine Voltage Reporters, or RhoVRs, use photoinduced electron transfer (PeT) as a trigger for voltage sensing, display excitation and emission profiles in the green to orange region of the visible spectrum, demonstrate high sensitivity to membrane potential changes (up to 47% ΔF/F per 100 mV), and employ a tertiary amide derived from sarcosine, which aids in membrane localization and simultaneously simplifies the synthetic route to the voltage sensors. The most sensitive of the RhoVR dyes, RhoVR 1, features a methoxy-substituted diethylaniline donor and phenylenevinylene molecular wire at the 5'-position of the rhodamine aryl ring, exhibits the highest voltage sensitivity to date for red-shifted PeT-based voltage sensors, and is compatible with simultaneous imaging alongside green fluorescent protein-based indicators. The discoveries that sarcosine-based tertiary amides in the context of molecular-wire voltage indicators prevent dye internalization and 5'-substituted voltage indicators exhibit improved voltage sensitivity should be broadly applicable to other types of PeT-based voltage-sensitive fluorophores.

  16. High Efficiency Power Converter for Low Voltage High Power Applications

    Nymand, Morten

    , and remote power generation for light towers, camper vans, boats, beacons, and buoys etc. A review of current state-of-the-art is presented. The best performing converters achieve moderately high peak efficiencies at high input voltage and medium power level. However, system dimensioning and cost are often......The topic of this thesis is the design of high efficiency power electronic dc-to-dc converters for high-power, low-input-voltage to high-output-voltage applications. These converters are increasingly required for emerging sustainable energy systems such as fuel cell, battery or photo voltaic based...... determined by the performance at the system worst case operating point which is usually at minimum input voltage and maximum power. Except for the non-regulating V6 converters, all published solutions exhibit a very significant drop in conversion efficiency at minimum input voltage and maximum output power...

  17. A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion.

    Grefen, Christopher; Karnik, Rucha; Larson, Emily; Lefoulon, Cécile; Wang, Yizhou; Waghmare, Sakharam; Zhang, Ben; Hills, Adrian; Blatt, Michael R


    Growth in plants depends on ion transport for osmotic solute uptake and secretory membrane trafficking to deliver material for wall remodelling and cell expansion. The coordination of these processes lies at the heart of the question, unresolved for more than a century, of how plants regulate cell volume and turgor. Here we report that the SNARE protein SYP121 (SYR1/PEN1), which mediates vesicle fusion at the Arabidopsis plasma membrane, binds the voltage sensor domains (VSDs) of K(+) channels to confer a voltage dependence on secretory traffic in parallel with K(+) uptake. VSD binding enhances secretion in vivo subject to voltage, and mutations affecting VSD conformation alter binding and secretion in parallel with channel gating, net K(+) concentration, osmotic content and growth. These results demonstrate a new and unexpected mechanism for secretory control, in which a subset of plant SNAREs commandeer K(+) channel VSDs to coordinate membrane trafficking with K(+) uptake for growth.

  18. Adaptive coordinated control of engine speed and battery charging voltage

    Jiangyan ZHANG; Xiaohong JIAO


    In this paper, the control problem of auxiliary power unit (APU) for hybrid electric vehicles is investigated. An adaptive controller is provided to achieve the coordinated control between the engine speed and the battery charging voltage. The proposed adaptive coordinated control laws for the throttle angle of the engine and the voltage of the power-converter can guarantee not only the asymptotic tracking performance of the engine speed and the regulation of the battery charging voltage, but also the robust stability of the closed loop system under external load changes. Simulation results are given to verify the performance of the proposed adaptive controller.

  19. Implementation of an outline of transformer induced voltage tests

    Orestes Hernández Areu


    Full Text Available The results of the developed work for the implementation of the induced voltage test to be applied to single phase distribution transformers in the Researches and Electroenergetic Tests Center (CIPEL of Cuba, are presented, The test outline was obtained starting from the employment of a motor - generator group, with an external voltage regulator and using a frequency converter to obtain the necessary frequency for this type of test.

  20. Voltage Dependence of Supercapacitor Capacitance

    Szewczyk Arkadiusz


    Full Text Available Electronic Double-Layer Capacitors (EDLC, called Supercapacitors (SC, are electronic devices that are capable to store a relatively high amount of energy in a small volume comparing to other types of capacitors. They are composed of an activated carbon layer and electrolyte solution. The charge is stored on electrodes, forming the Helmholtz layer, and in electrolyte. The capacitance of supercapacitor is voltage- dependent. We propose an experimental method, based on monitoring of charging and discharging a supercapacitor, which enables to evaluate the charge in an SC structure as well as the Capacitance-Voltage (C-V dependence. The measurement setup, method and experimental results of charging/discharging commercially available supercapacitors in various voltage and current conditions are presented. The total charge stored in an SC structure is proportional to the square of voltage at SC electrodes while the charge on electrodes increases linearly with the voltage on SC electrodes. The Helmholtz capacitance increases linearly with the voltage bias while a sublinear increase of total capacitance was found. The voltage on SC increases after the discharge of electrodes due to diffusion of charges from the electrolyte to the electrodes. We have found that the recovery voltage value is linearly proportional to the initial bias voltage value.

  1. Load distribution model and voltage static profile of Smart Grid

    SUN Qiu-ye; LI Zhong-xu; YANG Jun; LUO Yan-hong


    Voltage profiles of feeders with the connection of distributed generations(DGs)were investigated.A unified typical load distribution model was established.Based on this model,exact expressions of feeder voltage profile with single and double DGs were derived and used to analyze the impact of DG's location and capacity on the voltage profile quantitatively.Then,a general formula of the voltage profile was derived.The limitation of single DG and necessity of multiple DGs for voltage regulation were also discussed.Through the simulation,voltage profiles of feeders with single and double DGs were compared.The voltage excursion rate is 7.40% for only one DG,while 2.48% and 2.36% for double DGs.It is shown that the feeder voltage can be retained in a more appropriate range with multiple DGs than with only one DG.Distributing the total capacity of DGs is better than concentrating it at one point.

  2. Cooperative Control with Virtual Selective Harmonic Capacitance for Harmonic Voltage Compensation in Islanded MicroGrids

    Micallef, A.; Apap, M.; Spitero-Stanies, C.


    This paper focuses on the islanded operation of microgrids. In this mode of operation, the microsources are required to cooperate autonomously to regulate the local grid voltage and frequency. Droop control is typically used to achieve this autonomous voltage and frequency regulation. Inverters...... having LCL output filters would cause voltage distortion to be present at the PCC of the local load when non-linear current is supplied to the load due to the voltage drop across the grid side inductor. Techniques to reduce the output voltage distortion typically consist of installing either passive...... loop, implemented in each of the microsource inverters, is proposed so as to dampen the voltage harmonics at the PCC of the local load. Simulation results are presented showing the suitability of the proposed algorithm in dampening the PCC voltage harmonics....

  3. Wide Operational Range Processor Power Delivery Design for Both Super-Threshold Voltage and Near-Threshold Voltage Computing

    Xin He; Gui-Hai Yan; Yin-He Han; Xiao-Wei Li


    The load power range of modern processors is greatly enlarged because many advanced power management techniques are employed, such as dynamic voltage frequency scaling, Turbo Boosting, and near-threshold voltage (NTV) technologies. However, because the efficiency of power delivery varies greatly with different load conditions, conventional power delivery designs cannot maintain high efficiency over the entire voltage spectrum, and the gained power saving may be offset by power loss in power delivery. We propose SuperRange, a wide operational range power delivery unit. SuperRange complements the power delivery capability of on-chip voltage regulator and off-chip voltage regulator. On top of SuperRange, we analyze its power conversion characteristics and propose a voltage regulator (VR) aware power management algorithm. Moreover, as more and more cores have been integrated on a singe chip, multiple SuperRange units can serve as basic building blocks to build, in a highly scalable way, more powerful power delivery subsystem with larger power capacity. Experimental results show SuperRange unit offers 1x and 1.3x higher power conversion efficiency (PCE) than other two conventional power delivery schemes at NTV region and exhibits an average 70%PCE over entire operational range. It also exhibits superior resilience to power-constrained systems.

  4. Flexible voltage support control for three-phase distributed generation inverters under grid fault

    Camacho, Antonio; Castilla, Miguel; Miret, Jaume


    Operators describe the behavior of the energy source, regulating voltage limits and reactive power injection to remain connected and support the grid under fault. On the basis that different kinds of voltage sags require different voltage support strategies, a flexible control scheme for three phase grid......Ancillary services for distributed generation systems become a challenging issue to smartly integrate renewable energy sources into the grid. Voltage control is one of these ancillary services which can ride through and support the voltage under grid faults. Grid codes from the Transmission System...... connected inverters is proposed. In three phase balanced voltage sags, the inverter should inject reactive power in order to raise the voltage in all phases. In one or two phase faults, the main concern of the distributed generation inverter is to equalize voltages by reducing the negative symmetric...

  5. Impacts on Power Factor of AC Voltage Controllers Under Non-Sinusoidal Conditions

    Mukhtiar Ahmed Mahar


    Full Text Available AC-AC conversion is obtained with the help of Cyclo-converters, DC Link converters and AC Voltage Controllers. AC voltage controllers are also referred to as voltage regulators. Main issue concerned to these converters is that they generate harmonics due to periodic variable structure system. The generated harmonics create disturbances and degrade the performance of converter. The power factor of supply side is affected due to these harmonics. This paper focuses on source side power factor of ac voltage controllers under nonsinusoidal conditions. In order to observe the power factor, measurement tool of power factor and simulation model of ac voltage controller is also developed in MATLAB software.

  6. Safe epoxy encapsulant for high voltage magnetics

    Sanchez, R.O.; Archer, W.E.


    This paper describes the use of Formula 456, an aliphatic amine cured epoxy for impregnating coils and high voltage transformers. Sandia has evaluated a number of MDA-free epoxy encapsulants which relied on either anhydride or other aromatic amine curing agents. The use of aliphatic amine curing agents was more recently evaluated and has resulted in the definition of Formula 456 resin. Methylene dianiline (MDA) has been used for more than 20 years as the curing agent for various epoxy formulations throughout the Department of Energy and much of industry. Sandia National Laboratories began the process of replacing MDA with other formulations because of regulations imposed by OSHA on the use of MDA. OSHA has regulated MDA because it is a suspect carcinogen. Typically the elimination of OSHA-regulated materials provides a rare opportunity to qualify new formulations in a range of demanding applications. It was important to take full advantage of that opportunity, although the associated materials qualification effort was costly. Small high voltage transformers are one of those demanding applications. The successful implementation of the new formulation for high reliability transformers will be described. The test results that demonstrate the parts are qualified for use in DOE weapon systems will be presented.

  7. Power flow analysis for DC voltage droop controlled DC microgrids

    Li, Chendan; Chaudhary, Sanjay; Dragicevic, Tomislav


    This paper proposes a new algorithm for power flow analysis in droop controlled DC microgrids. By considering the droop control in the power flow analysis for the DC microgrid, when compared with traditional methods, more accurate analysis results can be obtained. The algorithm verification...... is carried out by comparing the calculation results with detailed time domain simulation results. With the droop parameters as variables in the power flow analysis, their effects on power sharing and secondary voltage regulation can now be analytically studied, and specialized optimization in the upper level...... control can also be made accordingly. Case studies on power sharing and secondary voltage regulation are carried out using proposed power flow analysis....

  8. On-chip High-Voltage Generator Design

    Tanzawa, Toru


    This book describes high-voltage generator design with switched-capacitor multiplier techniques.  The author provides various design techniques for switched-capacitor on-chip high-voltage generators, including charge pump circuits, regulators, level shifters, references, and oscillators.  Readers will see these techniques applied to system design in order to address the challenge of how the on-chip high-voltage generator is designed for Flash memories, LCD drivers, and other semiconductor devices to optimize the entire circuit area and power efficiency with a low voltage supply, while minimizing the cost.   ·         Shows readers how to design charge pump circuits with lower voltage operation, higher power efficiency, and smaller circuit area; ·         Describes comprehensive circuits and systems design of on-chip high-voltage generators; ·         Covers all the component circuit blocks, including charge pumps, pump regulators, level shifters, oscillators, and references.

  9. Voltage-Gated Channels as Causative Agents for Epilepsies

    Mutasem Abuhamed


    Full Text Available Problem statement: Epilepsy is a common neurological disorder that afflicts 1-2% of the general population worldwide. It encompasses a variety of disorders with seizures. Approach: Idiopathic epilepsies were defined as a heterogeneous group of seizure disorders that show no underlying cause .Voltage-gated ion channels defect were recognized etiology of epilepsy in the central nervous system. The aim of this article was to provide an update on voltage-gated channels and their mutation as causative agents for epilepsies. We described the structures of the voltage-gated channels, discuss their current genetic studies, and then review the effects of voltage-gated channels as causative agents for epilepsies. Results: Channels control the flow of ions in and out of the cell causing depolarization and hyper polarization of the cell. Voltage-gated channels were classified into four types: Sodium, potassium calcium ands chloride. Voltage-gated channels were macromolecular protein complexes within the lipid membrane. They were divided into subunits. Each subunit had a specific function and was encoded by more than one gen. Conclusion: Current genetic studies of idiopathic epilepsies show the importance of genetic influence on Voltage-gated channels. Different genes may regulate a function in a channel; the channel defect was directly responsible for neuronal hyper excitability and seizures.

  10. Variation-aware adaptive voltage scaling for digital CMOS circuits

    Wirnshofer, Martin


    Increasing performance demands in integrated circuits, together with limited energy budgets, force IC designers to find new ways of saving power. One innovative way is the presented adaptive voltage scaling scheme, which tunes the supply voltage according to the present process, voltage and temperature variations as well as aging. The voltage is adapted “on the fly” by means of in-situ delay monitors to exploit unused timing margin, produced by state-of-the-art worst-case designs. This book discusses the design of the enhanced in-situ delay monitors and the implementation of the complete control-loop comprising the monitors, a control-logic and an on-chip voltage regulator. An analytical Markov-based model of the control-loop is derived to analyze its robustness and stability. Variation-Aware Adaptive Voltage Scaling for Digital CMOS Circuits provides an in-depth assessment of the proposed voltage scaling scheme when applied to an arithmetic and an image processing circuit. This book is written for engine...

  11. New zero voltage switching DC converter with flying capacitors

    Lin, Bor-Ren; Shiau, Tung-Yuan


    A new soft switching converter is presented for medium power applications. Two full-bridge converters are connected in series at high voltage side in order to limit the voltage stress of power switches at Vin/2. Therefore, power metal-oxide-semiconductor field-effect transistors (MOSFETs) with 600 V voltage rating can be adopted for 1200 V input voltage applications. In order to balance two input split capacitor voltages in every switching cycle, two flying capacitors are connected on the AC side of two full-bridge converters. Phase-shift pulse-width modulation (PS-PWM) is adopted to regulate the output voltage. Based on the resonant behaviour by the output capacitance of MOSFETs and the resonant inductance, active MOSFETs can be turned on under zero voltage switching (ZVS) during the transition interval. Thus, the switching losses of power MOSFETs are reduced. Two full-bridge converters are used in the proposed circuit to share load current and reduce the current stress of passive and active components. The circuit analysis and design example of the prototype circuit are provided in detail and the performance of the proposed converter is verified by the experiments.

  12. Voltage Sensors Monitor Harmful Static


    A tiny sensor, small enough to be worn on clothing, now monitors voltage changes near sensitive instruments after being created to alert Agency workers to dangerous static buildup near fuel operations and avionics. San Diego s Quasar Federal Systems received a Small Business Innovation Research (SBIR) contract from Kennedy Space Center to develop its remote voltage sensor (RVS), a dime-sized electrometer designed to measure triboelectric changes in the environment. One of the unique qualities of the RVS is that it can detect static at greater distances than previous devices, measuring voltage changes from a few centimeters to a few meters away, due to its much-improved sensitivity.

  13. An Experimental Study on Voltage Compensation Method using Autonomous Decentralized Control of Distributed Generators

    Tanaka, Shunsuke; Suzuki, Hirokazu

    When many distributed generators (DGs) are connected to a distribution line, the upward power flow from DGs causes the difficulty in line voltage regulation. As the countermeasure, we propose several methods to control the line voltage by use of DGs' reactive power outputs. These methods using only DGs' reactive power are implemented in an autonomous decentralized way. DGs with the function to estimate the line impedance provide the power system with reactive power according to the estimated impedance value, and regulate the line voltage. We evaluate the effect of the proposed methods for voltage compensation by experimental studies using commercial grid-connected inverters for PV system.

  14. Secondary control for reactive power sharing and voltage amplitude restoration in droop-controlled islanded microgrids

    Micallef, A.; Apap, M.; Spiteri Staines, C.


    This paper focuses on the islanded operation of microgrids. In this mode of operation, the microsources are required to cooperate autonomously to regulate the local grid voltage and frequency. Droop control is typically used to achieve this autonomous voltage and frequency regulation. However...... and to restore the voltage deviations caused by the droop control. Primary droop control loops where implemented in the inverters to supply the real and reactive power. Simulation results are presented showing the feasibility of the proposed algorithm in achieving reactive power sharing between the inverters...... connected to the microgrid while simultaneously restoring the voltage deviations due to the droop control....

  15. Low voltage bandgap reference with closed loop curvature compensation

    Tao, Fan; Bo, Du; Zheng, Zhang; Guoshun, Yuan


    A new low-voltage CMOS bandgap reference (BGR) that achieves high temperature stability is proposed. It feeds back the output voltage to the curvature compensation circuit that constitutes a closed loop circuit to cancel the logarithmic term of voltage VBE. Meanwhile a low voltage amplifier with the 0.5 μm low threshold technology is designed for the BGR. A high temperature stability BGR circuit is fabricated in the CSMC 0.5 μm CMOS technology. The measured result shows that the BGR can operate down to 1 V, while the temperature coefficient and line regulation are only 9 ppm/°C and 1.2 mV/V, respectively.

  16. Control voltage and power fluctuations when connecting wind farms

    Berinde, Ioan, E-mail:; Bălan, Horia, E-mail:; Oros, Teodora Susana, E-mail: [Technical University of Cluj-Napoca, Romania, Faculty of Electrical Engineering, Department of Power Engineering and Management (Romania)


    Voltage, frequency, active power and reactive power are very important parameters in terms of power quality. These parameters are followed when connecting any power plant, the more the connection of wind farms. Connecting wind farms to the electricity system must not cause interference outside the limits set by regulations. Modern solutions for fast and automatic voltage control and power fluctuations using electronic control systems of reactive power flows. FACTS (Flexible Alternating Current Transmision System) systems, established on the basis of power electronic circuits ensure control of electrical status quantities to achieve the necessary transfer of power to the power grid. FACTS devices can quickly control parameters and sizes of state power lines, such as impedance line voltages and phase angles of the voltages of the two ends of the line. Their use can lead to improvement in power system operation by increasing the transmission capacity of power lines, power flow control lines, improved static and transient stability reserve.

  17. Low voltage bandgap reference with closed loop curvature compensation

    Fan Tao; Du Bo; Zhang Zheng; Yuan Guoshun


    A new low-voltage CMOS bandgap reference (BGR) that achieves high temperature stability is proposed. It feeds back the output voltage to the curvature compensation circuit that constitutes a closed loop circuit to cancel the logarithmic term of voltage VBE. Meanwhile a low voltage amplifier with the 0.5μm low threshold technology is designed for the BGR. A high temperature stability BGR circuit is fabricated in the CSMC 0.5μm CMOS tech-nology. The measured result shows that the BGR can operate down to 1 V, while the temperature coefficient and line regulation are only 9 ppm/℃ and 1.2 mV/V, respectively.

  18. Design and Implementation of a High-Voltage Generator with Output Voltage Control for Vehicle ER Shock-Absorber Applications

    Chih-Lung Shen


    Full Text Available A self-oscillating high-voltage generator is proposed to supply voltage for a suspension system in order to control the damping force of an electrorheological (ER fluid shock absorber. By controlling the output voltage level of the generator, the damping force in the ER fluid shock absorber can be adjusted immediately. The shock absorber is part of the suspension system. The high-voltage generator drives a power transistor based on self-excited oscillation, which converts dc to ac. A high-frequency transformer with high turns ratio is used to increase the voltage. In addition, the system uses the car battery as dc power supply. By regulating the duty cycle of the main switch in the buck converter, the output voltage of the buck converter can be linearly adjusted so as to obtain a specific high voltage for ER. The driving system is self-excited; that is, no additional external driving circuit is required. Thus, it reduces cost and simplifies system structure. A prototype version of the actual product is studied to measure and evaluate the key waveforms. The feasibility of the proposed system is verified based on experimental results.

  19. VLSI Hybrid DC-DC Regulator

    Cosp Vilella, Jordi; Martínez García, Herminio


    Hybrid DC-DC regulators are structures that combine both a linear voltage regulator and a switching DC-DC converter. The main objective of this hybrid topology is to converge, in a single circuit topology, the best of both alternatives: a small voltage output ripple, which is a common characteristic of linear regulator circuits, and good energy efficiency, as in switching alternatives. While the linear regulator fixes the required output voltage to a fixed value with negligible steady-state r...

  20. Modular High Voltage Power Supply

    Newell, Matthew R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    The goal of this project is to develop a modular high voltage power supply that will meet the needs of safeguards applications and provide a modular plug and play supply for use with standard electronic racks.

  1. Reliability criteria for voltage stability

    Taylor, Carson W.; Silverstein, Brian L. [Bonneville Power Administration, Portland, OR (United States)


    In face of costs pressures, there is need to allocate scare resources more effectively in order to achieve voltage stability. This naturally leads to development of probabilistic criteria and notions of rick management. In this paper it is presented a discussion about criteria for long term voltage stability limited to the case in which the time frames are topically several minutes. (author) 14 refs., 1 fig.

  2. A Voltage Quality Detection Method

    Chen, Zhe; Wei, Mu


    This paper presents a voltage quality detection method based on a phase-locked loop (PLL) technique. The technique can detect the voltage magnitude and phase angle of each individual phase under both normal and fault power system conditions. The proposed method has the potential to evaluate vario...... power quality disturbances, such as interruptions, sags and imbalances. Simulation studies have been performed. The effectiveness of the proposed method has been demonstrated under the simulated typical power disturbances....

  3. A matter of quantum voltages.

    Sellner, Bernhard; Kathmann, Shawn M


    Voltages inside matter are relevant to crystallization, materials science, biology, catalysis, and aqueous chemistry. The variation of voltages in matter can be measured by experiment, however, modern supercomputers allow the calculation of accurate quantum voltages with spatial resolutions of bulk systems well beyond what can currently be measured provided a sufficient level of theory is employed. Of particular interest is the Mean Inner Potential (V(o))--the spatial average of these quantum voltages referenced to the vacuum. Here we establish a protocol to reliably evaluate V(o) from quantum calculations. Voltages are very sensitive to the distribution of electrons and provide metrics to understand interactions in condensed phases. In the present study, we find excellent agreement with measurements of V(o) for vitrified water and salt crystals and demonstrate the impact of covalent and ionic bonding as well as intermolecular/atomic interactions. Certain aspects in this regard are highlighted making use of simple model systems/approximations. Furthermore, we predict V(o) as well as the fluctuations of these voltages in aqueous NaCl electrolytes and characterize the changes in their behavior as the resolution increases below the size of atoms.

  4. 基于电压调节的行波超声波电机转速模糊PID控制%Fuzzy PID Speed Control of Traveling Wave Ultrasonic Motor Using Voltage Amplitude Regulation

    史敬灼; 张慧敏


    Accordance with ultrasonic motor's time-variable nonlinearity, a online adaptive correction based on fuzzy logic was presented. The special nature of ultrasonic motor's speed control were fully taken into account in designing fuzzy rules. The amplitude of driving voltage was used as the control parameter to realite the control method. The experiments indicate that the control characteristics are much better than that of PID controller.%针对超声波电机的时变非线性,给出了基于模糊逻辑的PID控制参数在线自适应校正方法.模糊规则设计中充分考虑了超声波电机转速控制的特殊性.采用驱动电压幅值作为控制量,实现了该控制方法.实验表明,控制性能优于PID控制器.

  5. Regulation of neuronal L-type voltage-gated calcium channels and brain ischemia%中枢神经系统L-型电压门控钙通道的功能调控与脑缺血

    侯筱宇; 张光毅


    中枢神经系统L-型电压门控钙通道(L-type voltage-gated calcium channels, L-VGCCs)由α1C(D)亚基和辅助亚基组成.α1C亚基的C-端包含多个功能结构域,可分别与钙调素、钙调蛋白酶、cAMP依赖性蛋白激酶、Src家族酪氨酸蛋白激酶(Src family protein tyrosine kinases,SrcPTKs)等相互作用,从而参与L-VGCCs的功能调控.SrcPTKs介导的两种钙通道-- L-VGCCs和N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)受体的对话可能是缺血性脑损伤的重要机制.

  6. Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study.

    Zile, Melanie A; Trayanova, Natalia A


    Microvolt T-wave alternans (MTWA) testing identifies heart failure patients at risk for lethal ventricular arrhythmias at near-resting heart rates (voltage alternans (APV-ALT), the cellular driver of MTWA. Our goal was to uncover the mechanisms linking APV-ALT and FORCE-ALT in failing human myocytes and to investigate how the link between those alternans was affected by pacing rate and by physiological conditions such as sarcomere length and heart failure induced-remodeling of mechanical parameters. To achieve this, a mechanically-based, strongly coupled human electromechanical myocyte model was constructed. Reducing the sarcoplasmic reticulum calcium uptake current (Iup) to 27% was incorporated to simulate abnormal calcium handling in human heart failure. Mechanical remodeling was incorporated to simulate altered thin filament activation and crossbridge (XB) cycling rates. A dynamical pacing protocol was used to investigate the development of intracellular calcium concentration ([Ca]i), voltage, and active force alternans at different pacing rates. FORCE-ALT only occurred in simulations incorporating reduced Iup, demonstrating that alternans in the intracellular calcium concentration (CA-ALT) induced FORCE-ALT. The magnitude of FORCE-ALT was found to be largest at clinically relevant pacing rates (<110 bpm), where APV-ALT was smallest. We found that the magnitudes of FORCE-ALT, CA-ALT and APV-ALT were altered by heart failure induced-remodeling of mechanical parameters and sarcomere length due to the presence of myofilament feedback. These findings provide important insight into the relationship between heart-failure-induced electrical and mechanical alternans and how they are altered by physiological conditions at near-resting heart rates.


    VOLTAGE COMPENSATION USING ARTIFICIAL NEURAL NETWORK: A CASE STUDY OF RUMUOLA DISTRIBUTION NETWORK. ... The artificial neural networks controller engaged to controlling the dynamic voltage ... Article Metrics.

  8. More stability and robustness with the multi-loop control solution for dynamic voltage restorer (DVR

    Abdelkhalek Othmane


    Full Text Available This paper presents the application of dynamic voltage restorers (DVR on power distribution systems for mitigation of voltage sags/swells at critical loads. DVR is one of the compensating types of custom power devices. An adequate modeling and simulation of DVR, including controls in MATLAB, based on forced-commutated voltage source converter (VSC, has been proved suitable for compensating the voltage sags/swells. In this paper, a double loop control method is proposed for the improvement of the stability of DVR during the load current variation. For the main loop (Outer Voltage Loop, we use a PI controller for the regulation of the filter condenser voltage. The second loop (Inner Current Loop also uses a PI controller to control the disturbances current during load variation. Simulation results are presented to illustrate and understand the performances of DVR in the compensation of voltage sags/swell even with variation load condition.

  9. High Bandwidth Zero Voltage Injection Method for Sensorless Control of PMSM

    Ge, Xie; Lu, Kaiyuan; Kumar, Dwivedi Sanjeet


    High frequency signal injection is widely used in PMSM sensorless control system for low speed operations. The conventional voltage injection method often needs filters to obtain particular harmonic component in order to estimate the rotor position; or it requires several voltage pulses to be inj...... in a fast current regulation performance. Injection of zero voltage also minimizes the inverter voltage error effects caused by the dead-time.......High frequency signal injection is widely used in PMSM sensorless control system for low speed operations. The conventional voltage injection method often needs filters to obtain particular harmonic component in order to estimate the rotor position; or it requires several voltage pulses...... to be injected before the position may be estimated. In this paper, a single pulse zero voltage injection method is proposed. The rotor position is directly estimated from the current ripple at half of the switching frequency. No machine parameters are needed and using of filters is avoided. This results...

  10. Electrode voltage fall and total voltage of a transient arc

    Valensi, F.; Ratovoson, L.; Razafinimanana, M.; Masquère, M.; Freton, P.; Gleizes, A.


    This paper deals with an experimental study of the components of a transient arc total voltage with duration of a few tens of ms and a current peak close to 1000 A. The cathode tip is made of graphite whereas the flat anode is made either of copper or of graphite; the electrodes gap is a few mm. The analysis of the electrical parameters is supported and validated by fast imaging and by two models: the first one is a 2D physical model of the arc allowing to calculate both the plasma temperature field and the arc voltage; the second model is able to estimate the transient heating of the graphite electrode. The main aim of the study was to detect the possible change of the cathode voltage fall (CVF) during the first instants of the arc. Indeed it is expected that during the first ms the graphite cathode is rather cool and the main mechanism of the electron emission should be the field effect emission, whereas after several tens of ms the cathode is strongly heated and thermionic emission should be predominant. We have observed some change in the apparent CVF but we have shown that this apparent change can be attributed to the variation of the solid cathode resistance. On the other hand, the possible change of CVF corresponding to the transition between a ‘cold’ and a ‘hot’ cathode should be weak and could not be characterized considering our measurement uncertainty of about 2 V. The arc column voltage (ACV) was estimated by subtracting the electrode voltage fall from the total arc voltage. The experimental transient evolution of the ACV is in very good agreement with the theoretical variation predicted by the model, showing the good ability of the model to study this kind of transient arc.

  11. Dynamic Analysis of Power System Voltage Stability.

    Gebreselassie, Assefa

    This thesis investigates the effects of loads and voltage regulators on the dynamic voltage stability of power systems. The analysis focuses on the interactions of machine flux dynamics with loads and voltage control devices. The results are based on eigenvalue analysis of the linearized models and time simulation of the nonlinear models, using models from the Power System Toolbox, a Matlab -based package for the simulation and small signal analysis of nonlinear power systems. The voltage stability analysis results are developed using a single machine single load system with typical machine and network parameters and the NPCC 10-machine system. Dynamic models for generators, exciters and loads are used. The generator is modeled with a pair of poles and one damper circuit in both the d-axis and the q-axis. Saturation effects are included in the model. The IEEE Type DC1 DC commutator exciter model is used for all the exciters. Five different types of loads: constant impedance, constant current, constant power, a first order induction motor model (slip model) and a third order induction motor model (slip-flux model) are considered. The modes of instability and the stability limits of the different representation of loads are examined for two different operating modes of the exciters. The first, when all the exciters are on automatic control and the second when some exciters are on manual control. Modal participation factors are used to determine the characteristics of the critical modes. The characteristics of the unstable modes are verified by performing time simulation of the nonlinear models. Oscillatory and non-oscillatory instabilities are experienced by load buses when all the exciters are on automatic control and some exciters are on manual control respectively, for loads which are predominantly constant power and induction motors. It is concluded that the mode of instability does not depend on the type of loads but on the operating condition of the exciters

  12. Unbalanced Voltage Compensation in Low Voltage Residential AC Grids

    Trintis, Ionut; Douglass, Philip; Munk-Nielsen, Stig


    This paper describes the design and test of a control algorithm for active front-end rectifiers that draw power from a residential AC grid to feed heat pump loads. The control algorithm is able to control the phase to neutral or phase to phase RMS voltages at the point of common coupling....... The voltage control was evaluated with either active or reactive independent phase load current control. The control performance in field operation in a residential grid situated in Bornholm, Denmark was investigated for different use cases....

  13. Automated Voltage Control in LHCb

    Granado Cardoso, L; Jacobsson, R


    LHCb is one of the 4 LHC experiments. In order to ensure the safety of the detector and to maximize efficiency, LHCb needs to coordinate its own operations, in particular the voltage configuration of the different subdetectors, according to the accelerator status. A control software has been developed for this purpose, based on the Finite State Machine toolkit and the SCADA system used for control throughout LHCb (and the other LHC experiments). This software permits to efficiently drive both the Low Voltage (LV) and High Voltage (HV) systems of the 10 different sub-detectors that constitute LHCb, setting each sub-system to the required voltage (easily configurable at run-time) based on the accelerator state. The control software is also responsible for monitoring the state of the Sub-detector voltages and adding it to the event data in the form of status-bits. Safe and yet flexible operation of the LHCb detector has been obtained and automatic actions, triggered by the state changes of the ...

  14. Voltage-gated proton channel is expressed on phagosomes.

    Okochi, Yoshifumi; Sasaki, Mari; Iwasaki, Hirohide; Okamura, Yasushi


    Voltage-gated proton channel has been suggested to help NADPH oxidase activity during respiratory burst of phagocytes through its activities of compensating charge imbalance and regulation of pH. In phagocytes, robust production of reactive oxygen species occurs in closed membrane compartments, which are called phagosomes. However, direct evidence for the presence of voltage-gated proton channels in phagosome has been lacking. In this study, the expression of voltage-gated proton channels was studied by Western blot with the antibody specific to the voltage-sensor domain protein, VSOP/Hv1, that has recently been identified as the molecular correlate for the voltage-gated proton channel. Phagosomal membranes of neutrophils contain VSOP/Hv1 in accordance with subunits of NADPH oxidases, gp91, p22, p47 and p67. Superoxide anion production upon PMA activation was significantly reduced in neutrophils from VSOP/Hv1 knockout mice. These are consistent with the idea that voltage-gated proton channels help NADPH oxidase in phagocytes to produce reactive oxygen species.

  15. Up-regulation of L-type high voltage-gated calcium channel subunits by sustained exposure to 1,4- and 1,5-benzodiazepines in cerebrocortical neurons.

    Katsura, Masashi; Shibasaki, Masahiro; Kurokawa, Kazuhiro; Tsujimura, Atsushi; Ohkuma, Seitaro


    The aim of this study is to examine how sustained exposure to two 1,4-benzodiazepines (BZDs) with different action period, diazepam and brotizolam, and a 1,5-BZD, clobazam, affects L-type high voltage-gated calcium channel (HVCC) functions and its mechanisms using primary cultures of mouse cerebral cortical neurons. The sustained exposure to these three BZDs increased [(45)Ca2+] influx, which was due to the enhanced [(45)Ca2+] entry through L-type HVCCs but not through of Cav2.1 and Cav2.2. Increase in [(3)H]diltiazem binding after the exposure to these three BZDs was due to the increase in the binding sites of [(3)H]diltiazem. Western blot analysis showed increase of Cav1.2 and Cav1.3 in association with the increased expression of alpha2/delta1 subunit. Similar changes in [(3)H]diltiazem binding and L-type HVCC subunit expression were found in the cerebral cortex from mouse with BZD physical dependence. These results indicate that BZDs examined here have the potential to increase L-type HVCC functions mediated via the enhanced expression of not only Cav1.2 and Cav1.3 but also alpha2/delta1 subunit after their sustained exposure, which may participate in the development of physical dependence by these BZDs.

  16. Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset.

    Kis-Toth, Katalin; Hajdu, Peter; Bacskai, Ildiko; Szilagyi, Orsolya; Papp, Ferenc; Szanto, Attila; Posta, Edit; Gogolak, Peter; Panyi, Gyorgy; Rajnavolgyi, Eva


    Expression of CD1a protein defines a human dendritic cell (DC) subset with unique functional activities. We aimed to study the expression of the Nav1.7 sodium channel and the functional consequences of its activity in CD1a(-) and CD1a(+) DC. Single-cell electrophysiology (patch-clamp) and quantitative PCR experiments performed on sorted CD1a(-) and CD1a(+) immature DC (IDC) showed that the frequency of cells expressing Na(+) current, current density, and the relative expression of the SCN9A gene encoding Nav1.7 were significantly higher in CD1a(+) cells than in their CD1a(-) counterparts. The activity of Nav1.7 results in a depolarized resting membrane potential (-8.7 ± 1.5 mV) in CD1a(+) IDC as compared with CD1a(-) cells lacking Nav1.7 (-47 ± 6.2 mV). Stimulation of DC by inflammatory signals or by increased intracellular Ca(2+) levels resulted in reduced Nav1.7 expression. Silencing of the SCN9A gene shifted the membrane potential to a hyperpolarizing direction in CD1a(+) IDC, resulting in decreased cell migration, whereas pharmacological inhibition of Nav1.7 by tetrodotoxin sensitized the cells for activation signals. Fine-tuning of IDC functions by a voltage-gated sodium channel emerges as a new regulatory mechanism modulating the migration and cytokine responses of these DC subsets.

  17. Development of a New Cascade Voltage-Doubler for Voltage Multiplication

    Arash Toudeshki; Norman Mariun; Hashim Hizam; Noor Izzri Abdul Wahab


    For more than eight decades, cascade voltage-doubler circuits are used as a method to produce DC output voltage higher than the input voltage. In this paper, the topological developments of cascade voltage-doublers are reviewed. A new circuit configuration for cascade voltage-doubler is presented. This circuit can produce a higher value of the DC output voltage and better output quality compared to the conventional cascade voltage-doubler circuits, with the same number of stages.

  18. Low-Energy Real-Time OS Using Voltage Scheduling Algorithm for Variable Voltage Processors

    Okuma, Takanori; Yasuura, Hiroto


    This paper presents a real-time OS based on $ mu $ITRON using proposed voltage scheduling algorithm for variable voltage processors which can vary supply voltage dynamically. The proposed voltage scheduling algorithms assign voltage level for each task dynamically in order to minimize energy consumption under timing constraints. Using the presented real-time OS, running tasks with low supply voltage leads to drastic energy reduction. In addition, the presented voltage scheduling algorithm is ...

  19. 30 CFR 18.47 - Voltage limitation.


    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Voltage limitation. 18.47 Section 18.47 Mineral... § 18.47 Voltage limitation. (a) A tool or switch held in the operator's hand or supported against his... particular voltage(s) are provided in the design and construction of the equipment, its wiring,...

  20. Cavity Voltage Phase Modulation MD

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department


    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  1. Portable High Voltage Impulse Generator

    S. Gómez


    Full Text Available This paper presents a portable high voltage impulse generator which was designed and built with insulation up to 20 kV. This design was based on previous work in which simulation software for standard waves was developed. Commercial components and low-cost components were used in this work; however, these particular elements are not generally used for high voltage applications. The impulse generators used in industry and laboratories are usually expensive; they are built to withstand extra high voltage and they are big, making them impossible to transport. The proposed generator is portable, thereby allowing tests to be made on devices that cannot be moved from their location. The results obtained with the proposed impulse generator were satisfactory in terms of time and waveforms compared to other commercial impulse generators and the standard impulse wave simulator.

  2. A Saturated Output Feedback Controller for the Three Phase Voltage Sourced Reversible Boost Type Rectifier

    Escobar, Gerardo; Ortega, Romeo; Schaft, Arjan J. van der


    In this article, we present a saturating controller to regulate the output voltage load in a three phase Boost type rectifier. The controller only needs the output voltage signal to be implemented. Moreover, by forcing the inductance currents to track desired suitable sinusoidal signals in phase wit

  3. Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

    Pless, Stephan Alexander; Galpin, Jason D; Niciforovic, Ana P


    Voltage-gated potassium (Kv) channels enable potassium efflux and membrane repolarization in excitable tissues. Many Kv channels undergo a progressive loss of ion conductance in the presence of a prolonged voltage stimulus, termed slow inactivation, but the atomic determinants that regulate the k...

  4. Implementation of Dynamic Voltage Restorer for Mitigation of Voltage Sag

    K.Vinod Kumar


    Full Text Available Power quality is one of major concerns in the present. It has become important, especially with the introduction of sophisticated devices, whose performance is very sensitive to the quality of power supply. The dynamic voltage restorer (DVR is one of the modern devices used in distribution systems to improve the power quality. In this paper, emergency control in distribution systems is discussed by using the proposed multifunctional DVR control strategy.Also, themultiloop controller using the Posicast and P+Resonant controllers is proposed in order to improve the transient response and eliminate the steady state error in DVR response,respectively.The proposed process is applied to some riots in load voltage effected by induction motors starting, and a three-phase short circuit fault. The three-phase short circuits, and the large induction motors are suddenly started then voltage sags areoccurred.The innovation here is that by using the Multifunctional Dynamic Voltage Restorer, improve the power quality in distribution side. Simulation results show the capability of the DVR to control the emergency conditions of the distribution systems by using MATLAB/Simulink software.

  5. The high voltage homopolar generator

    Price, J. H.; Gully, J. H.; Driga, M. D.


    System and component design features of proposed high voltage homopolar generator (HVHPG) are described. The system is to have an open circuit voltage of 500 V, a peak output current of 500 kA, 3.25 MJ of stored inertial energy and possess an average magnetic-flux density of 5 T. Stator assembly components are discussed, including the stator, mount structure, hydrostatic bearings, main and motoring brushgears and rotor. Planned operational procedures such as monitoring the rotor to full speed and operation with a superconducting field coil are delineated.

  6. Resilient architecture design for voltage variation

    Reddi, Vijay Janapa


    Shrinking feature size and diminishing supply voltage are making circuits sensitive to supply voltage fluctuations within the microprocessor, caused by normal workload activity changes. If left unattended, voltage fluctuations can lead to timing violations or even transistor lifetime issues that degrade processor robustness. Mechanisms that learn to tolerate, avoid, and eliminate voltage fluctuations based on program and microarchitectural events can help steer the processor clear of danger, thus enabling tighter voltage margins that improve performance or lower power consumption. We describe

  7. Contribution of variable-speed wind turbines to voltage control

    Ledesma, P.; Usaola, J.


    Variable speed, grid connected, wind turbines open new possibilities for voltage control, because they use electronic converters, which may regulate the reactive power interchange with the grid. This paper proposes two voltage control schemes for variable speed wind turbines with double-fed induction generator. The first scheme acts on the wind-turbine power factor, while the latter acts directly on the converter current. Advantages and draw backs of both techniques are discussed. Both control techniques have been tested by simulations of a base case, which represent a synchronous generator, a wind farm and a local load, and several disturbances such as the loss of compensator capacitors. (author)


    G.A. Senderovich


    Full Text Available Purpose. The purpose of work is development of a method of definition of the location of a source of fluctuations of voltage. Methodology. The reasons of emergence of fluctuations of voltage at an arrangement of a source both in power lines, and in the consumer's networks, are connected with changes of consumption and active and reactive capacities. As criterion for definition of the location of a source of fluctuations of voltage we choose change of size of the active power received by reception substation on equivalent communication with system. The source of fluctuations of voltage is external for the consumer if emergence of fluctuations of voltage leads to the coordinated changes of tension and consumed in the area of active power that corresponds to a condition of the positive regulating effect of active loading on voltage (1. The source of fluctuations of voltage is internal for the consumer if emergence of fluctuations of voltage leads to counter changes of tension and consumed in the area of active power that resembles a condition of the negative regulating effect of active loading on voltage superficially (6. Results. The method of definition of the location of a source of fluctuations of voltage in an electric network which, works by the principle of an assessment of correlation of change of power and tension in a power supply network is developed. The method allows to consider shift between extrema of curves of change of voltage of U(t and power of Pload(t. Originality. The method of definition of an arrangement of a source of fluctuations of voltage is developed. Practical value. The answer to this question where the source of fluctuations of voltage (in the territory of the consumer is located or in an external network confirmed with the determined calculation, can form a basis of the expert opinion for the solution of legal disputes at an assessment of the damages caused by poor quality of electric energy.

  9. An Integrated Chip High-Voltage Power Receiver for Wireless Biomedical Implants

    Vijith Vijayakumaran Nair


    Full Text Available In near-field wireless-powered biomedical implants, the receiver voltage largely overrides the compliance of low-voltage power receiver systems. To limit the induced voltage, generally, low-voltage topologies utilize limiter circuits, voltage clippers or shunt regulators, which are power-inefficient methods. In order to overcome the voltage limitation and improve power efficiency, we propose an integrated chip high-voltage power receiver based on the step down approach. The topology accommodates voltages as high as 30 V and comprises a high-voltage semi-active rectifier, a voltage reference generator and a series regulator. Further, a battery management circuit that enables safe and reliable implant battery charging based on analog control is proposed and realized. The power receiver is fabricated in 0.35-μm high-voltage Bipolar-CMOS-DMOStechnology based on the LOCOS0.35-μm CMOS process. Measurement results indicate 83.5% power conversion efficiency for a rectifier at 2.1 mA load current. The low drop-out regulator based on the current buffer compensation and buffer impedance attenuation scheme operates with low quiescent current, reduces the power consumption and provides good stability. The topology also provides good power supply rejection, which is adequate for the design application. Measurement results indicate regulator output of 4 ± 0.03 V for input from 5 to 30 V and 10 ± 0.05 V output for input from 11 to 30 V with load current 0.01–100 mA. The charger circuit manages the charging of the Li-ion battery through all if the typical stages of the Li-ion battery charging profile.

  10. Hierarchical Control for Voltage Harmonics Compensation in Multi-Area Microgrids

    Hashempour, Mohammad M.; Firoozabadi, Mehdi Savaghebi; Quintero, Juan Carlos Vasquez


    is proposed. Hierarchical control is applied to control DGs inverters and APFs in a coordinated way. Primary control consists of power droop controller of DGs, selective virtual impedance and voltage/current regulators. Based on the secondary control, voltage compensation of Points of Common Coupling (PCCs......) of multi-area microgrid is carried out by DGs. Voltage compensation of PCCs by DGs may cause violation from maximum allowable voltage distortion at DGs terminals. Thus, tertiary control is used to mitigate these violations by using APF in proper coordination with secondary control. Evaluation...

  11. Series Connected Buck-Boost Regulator

    Birchenough, Arthur G. (Inventor)


    A Series Connected Buck-Boost Regulator (SCBBR) that switches only a fraction of the input power, resulting in relatively high efficiencies. The SCBBR has multiple operating modes including a buck, a boost, and a current limiting mode, so that an output voltage of the SCBBR ranges from below the source voltage to above the source voltage.

  12. AC Voltage Control of DC/DC Converters Based on Modular Multilevel Converters in Multi-Terminal High-Voltage Direct Current Transmission Systems

    Rui Li


    Full Text Available The AC voltage control of a DC/DC converter based on the modular multilevel converter (MMC is considered under normal operation and during a local DC fault. By actively setting the AC voltage according to the two DC voltages of the DC/DC converter, the modulation index can be near unity, and the DC voltage is effectively utilized to output higher AC voltage. This significantly decreases submodule (SM capacitance and conduction losses of the DC/DC converter, yielding reduced capital cost, volume, and higher efficiency. Additionally, the AC voltage is limited in the controllable range of both the MMCs in the DC/DC converter; thus, over-modulation and uncontrolled currents are actively avoided. The AC voltage control of the DC/DC converter during local DC faults, i.e., standby operation, is also proposed, where only the MMC connected on the faulty cable is blocked, while the other MMC remains operational with zero AC voltage output. Thus, the capacitor voltages can be regulated at the rated value and the decrease of the SM capacitor voltages after the blocking of the DC/DC converter is avoided. Moreover, the fault can still be isolated as quickly as the conventional approach, where both MMCs are blocked and the DC/DC converter is not exposed to the risk of overcurrent. The proposed AC voltage control strategy is assessed in a three-terminal high-voltage direct current (HVDC system incorporating a DC/DC converter, and the simulation results confirm its feasibility.

  13. Decision from the Commission of Electricity Regulation (CRE) dated from December 12, 2002 about a disagreement between PEM Abrasif Refractaires (PEMAR) company and the Power transportation Network (RTE), as manager of the public power transportation grid, relative to the tariffing of public networks use applicable to the consumers connected in 42 kV voltage; Decision de la Commission de Regulation de l'Electricite (CRE) en date du 12 decembre 2002 sur un different qui oppose la societe PEM Abrasif Refractaires (PEMAR) a Reseau de Transport d'Electricite (RTE), en tant que gestionnaire du reseau public de transport d'electricite, relatif a la tarification d'utilisation des reseaux publics applicable aux consommateurs raccordes en tension 42 kV



    This document presents the analysis made by the French commission of electricity regulation (CRE) about a high voltage tariff disagreement between PEM Abrasif Refractaires (PEMAR) company (La Defense, Courbevoie France) and RTE, the French manager of the power transportation grid. PEMAR company claims for a contract of power supply tariff conformable with the application of the decree from July 19, 2002 which, after comparison with the previous decrees, contains a mistake in the definition of voltage classes. (J.S.)

  14. Modeling and Design of DC Boost and AC Side Voltage Controllers in Asymmetrical Γ-Source Inverter

    Seyed Mahyar Mehdizadeh Moghadam


    Full Text Available In this paper a control system is proposed to simultaneously control the voltage boost and output voltage of assymetrical Γ-Source Inverters. Dynamic model of the system is used to design the controllers. Voltage boost on assymetrical Γ-Source Inverters is done by voltage control of impedance network capacitor and the regulation of inverter shoot through duty cycle. Since the stability margin of the system is low due to the right half plane zero in its dynamic model, the design of fast control system is impossible therefore a nonlinear feedforward control loop is used to faster the control system performance. Linear control system is used to control the AC-side in synchrony reference frame such that the AC voltage control system regulates the output voltage by means of modulation index regulation. The proposed control system performance is investigated by simulation in MATLAB/Simulink

  15. Design and control of single-phase dynamic voltage restorer



    Dynamic voltage restorer (DVR) is a custom power device used in electrical distribution system for power quality improvement. It ensures regulated voltage supply to the sensitive loads, even in case of voltage sag and swell disturbances in the distribution network. It is a series connected device and compensates voltagesag and swell by injecting a voltage with the help of a series transformer. The injection of an appropriate voltage component in the event of a voltage disturbance requires a certain amount of real and reactive power. Conventionally,DVR consists of an energy storage device, which supplies the required power over the limited duration of the sags. Large magnitude and long duration of sags lead to heavy financial investment in energy storage unit. To overcome this limitation, a single-phase back-to-back converter-based DVR is implemented inthis work, which eliminates energy storage requirement. The integration of series and shunt converter makes the DVR capable of bidirectional flow of energy. Therefore, the key advantage of this topology is its capability to compensate for long-term voltage sag and swell. Modelling of the DVR and its controller design is included in this paper. The effectiveness of control schemes, protection schemes and starting sequence of operation of DVR is verified through detailed simulation studies. A scaled down laboratory prototype of DVR is developed. The viability of these schemes is confirmed by the experimental results generated from the laboratory prototype. Various challenges faced during the prototype development and corresponding solutions are also discussed in this paper.

  16. High Performance of Space Vector Modulation Direct Torque Control SVM-DTC Based on Amplitude Voltage and Stator Flux Angle

    Hassan Farhan Rashag


    Full Text Available Various aspects related to controlling induction motor are investigated. Direct torque control is an original high performance control strategy in the field of AC drive. In this proposed method, the control system is based on Space Vector Modulation (SVM, amplitude of voltage in direct- quadrature reference frame (d-q reference and angle of stator flux. Amplitude of stator voltage is controlled by PI torque and PI flux controller. The stator flux angle is adjusted by rotor angular frequency and slip angular frequency. Then, the reference torque and the estimated torque is applied to the input of PI torque controller and the control quadrature axis voltage is determined. The control d-axis voltage is determined from the flux calculator. These q and d axis voltage are converted into amplitude voltage. By applying polar to Cartesian on amplitude voltage and stator flux angle, direct voltage and quadratures voltage are generated. The reference stator voltages in d-q are calculated based on forcing the stator voltage error to zero at next sampling period. By applying inverse park transformation on d-q voltages, the stator voltages in &alpha and &beta frame are generated and apply to SVM. From the output of SVM, the motor control signal is generated and the speed of the induction motor regulated toward the rated speed. The simulation Results have demonstrated exceptional performance in steady and transient states and shows that decrease of torque and flux ripples is achieved in a complete speed range.

  17. Over-voltage protection system and method

    Chi, Song; Dong, Dong; Lai, Rixin


    An over-voltage protection system includes an electronic valve connected across two terminals of a circuit and an over-voltage detection circuit connected across one of the plurality of semiconductor devices for detecting an over-voltage across the circuit. The electronic valve includes a plurality of semiconductor devices connected in series. The over-voltage detection circuit includes a voltage divider circuit connected to a break-over diode in a way to provide a representative low voltage to the break-over diode and an optocoupler configured to receive a current from the break-over diode when the representative low voltage exceeds a threshold voltage of the break-over diode indicating an over-voltage condition. The representative low voltage provided to the break-over diode represents a voltage across the one semiconductor device. A plurality of self-powered gate drive circuits are connected to the plurality of semiconductor devices, wherein the plurality of self-powered gate drive circuits receive over-voltage triggering pulses from the optocoupler during the over-voltage condition and switch on the plurality of semiconductor devices to bypass the circuit.

  18. Advances in high voltage engineering

    Haddad, A


    This book addresses the very latest research and development issues in high voltage technology and is intended as a reference source for researchers and students in the field, specifically covering developments throughout the past decade. This unique blend of expert authors and comprehensive subject coverage means that this book is ideally suited as a reference source for engineers and academics in the field for years to come.

  19. High Voltage Pulse Testing Survey.


    Cryogenic 23 E. Liquids 26 F. Solids 28 1. Polyethylene 28 2. Cross-Linked Polyethylene ( XLPE ) 29 3. Polyimide and Polyvenylchloride (PVC) 31 VI Benefits 35 A...Strength of XLPE Cables 29 vii * 4" I PROGRAM OBJECTIVES The Pulse Test Survey summarizes government, industry, and technical reports on high voltage pulse...system of silicone oil on a XLPE (cross-linked polyethylene) spacer tends to lower the impulse breakdown by approximately 10 percent. The negative impulse


    Driver, G.E.


    High voltage, direct current power supplies are described for use with battery powered nuclear detection equipment. The particular advantages of the power supply described, are increased efficiency and reduced size and welght brought about by the use of transistors in the circuit. An important feature resides tn the employment of a pair of transistors in an alternatefiring oscillator circuit having a coupling transformer and other circuit components which are used for interconnecting the various electrodes of the transistors.

  1. Low voltage electron beam accelerators

    Ochi, Masafumi [Iwasaki Electric Co., Ltd., Tokyo (Japan)


    Widely used electron accelerators in industries are the electron beams with acceleration voltage at 300 kV or less. The typical examples are shown on manufactures in Japan, equipment configuration, operation, determination of process parameters, and basic maintenance requirement of the electron beam processors. New electron beam processors with acceleration voltage around 100 kV were introduced maintaining the relatively high dose speed capability of around 10,000 kGy x mpm at production by ESI (Energy Science Inc. USA, Iwasaki Electric Group). The application field like printing and coating for packaging requires treating thickness of 30 micron or less. It does not require high voltage over 110 kV. Also recently developed is a miniature bulb type electron beam tube with energy less than 60 kV. The new application area for this new electron beam tube is being searched. The drive force of this technology to spread in the industries would be further development of new application, process and market as well as the price reduction of the equipment, upon which further acknowledgement and acceptance of the technology to societies and industries would entirely depend. (Y. Tanaka)

  2. Piezo Voltage Controlled Planar Hall Effect Devices

    Bao Zhang; Kang-Kang Meng; Mei-Yin Yang; Edmonds, K. W.; Hao Zhang; Kai-Ming Cai; Yu Sheng; Nan Zhang; Yang Ji; Jian-Hua Zhao; Hou-Zhi Zheng; Kai-You Wang


    The electrical control of the magnetization switching in ferromagnets is highly desired for future spintronic applications. Here we report on hybrid piezoelectric (PZT)/ferromagnetic (Co2FeAl) devices in which the planar Hall voltage in the ferromagnetic layer is tuned solely by piezo voltages. The change of planar Hall voltage is associated with magnetization switching through 90° in the plane under piezo voltages. Room temperature magnetic NOT and NOR gates are demonstrated based on the pie...

  3. Bootstrapped Low-Voltage Analog Switches

    Steensgaard-Madsen, Jesper


    Novel low-voltage constant-impedance analog switch circuits are proposed. The switch element is a single MOSFET, and constant-impedance operation is obtained using simple circuits to adjust the gate and bulk voltages relative to the switched signal. Low-voltage (1-volt) operation is made feasible...

  4. Proportional integral plus multi-frequency resonant current controller for grid-connected voltage source converter under imbalanced and distorted supply voltage conditions

    Jia-bing HU; Wei ZHANG; Hong-sheng WANG; Yi-kang HE; Lie XU


    This paper proposes a current control scheme for a grid-connected pulse width modulator (PWM) voltage source converter (GC-VSC) under imbalanced and distorted supply voltage conditions. The control scheme is implemented in the positive synchronously rotating reference frame and composed of a single proportional integral (PI) regulator and multi-frequency resonant controllers tuned at the frequencies of 2ω and 6ω, respectively. The experimental results, with the target of eliminating the active power oscillations and current harmonics on a prototype GC-VSC system, validate the feasibility of the proposed current control scheme during supply voltage imbalance and distortion.

  5. KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain*


    Voltage-dependent potassium (Kv) channels are tetramers of six transmembrane domain (S1–S6) proteins. Crystallographic data demonstrate that the tetrameric pore (S5–S6) is surrounded by four voltage sensor domains (S1–S4). One key question remains: how do voltage sensors (S4) regulate pore gating? Previous mutagenesis data obtained on the Kv channel KCNQ1 highlighted the critical role of specific residues in both the S4-S5 linker (S4S5L) and S6 C terminus (S6T). From these data, we hypothesiz...

  6. Voltage Control for Unbalanced Low Voltage Grids Using a Decoupled-Phase On-Load Tap-Changer Transformer and Photovoltaic Inverters

    Zecchino, Antonio; Marinelli, Mattia; Hu, Junjie


    more renewable generations in the LV grid. The potential benefits are investigated in terms of voltage unbalance reduction and local voltage regulation. 24-hours root-mean-square dynamics simulation studies have been carried out with timestep of 1 second using 10-mins resolution consumption...... and production profiles. A totally passive real Danish low voltage distribution network is used for the grid topology as well as for the characterization of loads profiles, while the production ones are empirically defined under assumptions in scenarios with different level of photovoltaic penetration and grade...

  7. Voltage Control for Unbalanced Low Voltage Grids Using a Decoupled-Phase On-Load Tap-Changer Transformer and Photovoltaic Inverters

    Zecchino, Antonio; Marinelli, Mattia; Hu, Junjie; Coppo, Massimiliano; Turri, Roberto


    This paper presents modeling and analysis of the potential benefits of joint actions of a MV/LV three-phase power distribution transformer with independent on-load tap-changer control on each phase and photovoltaic inverters provided with reactive power control capability, in terms of accommodating more renewable generations in the LV grid. The potential benefits are investigated in terms of voltage unbalance reduction and local voltage regulation. 24-hours root-mean-square dynamics simulatio...

  8. Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1.

    Briones, Rodolfo; Weichbrodt, Conrad; Paltrinieri, Licia; Mey, Ingo; Villinger, Saskia; Giller, Karin; Lange, Adam; Zweckstetter, Markus; Griesinger, Christian; Becker, Stefan; Steinem, Claudia; de Groot, Bert L


    The voltage-dependent anion channel 1 (VDAC-1) is an important protein of the outer mitochondrial membrane that transports energy metabolites and is involved in apoptosis. The available structures of VDAC proteins show a wide β-stranded barrel pore, with its N-terminal α-helix (N-α) bound to its interior. Electrophysiology experiments revealed that voltage, its polarity, and membrane composition modulate VDAC currents. Experiments with VDAC-1 mutants identified amino acids that regulate the gating process. However, the mechanisms for how these factors regulate VDAC-1, and which changes they trigger in the channel, are still unknown. In this study, molecular dynamics simulations and single-channel experiments of VDAC-1 show agreement for the current-voltage relationships of an "open" channel and they also show several subconducting transient states that are more cation selective in the simulations. We observed voltage-dependent asymmetric distortions of the VDAC-1 barrel and the displacement of particular charged amino acids. We constructed conformational models of the protein voltage response and the pore changes that consistently explain the protein conformations observed at opposite voltage polarities, either in phosphatidylethanolamine or phosphatidylcholine membranes. The submicrosecond VDAC-1 voltage response shows intrinsic structural changes that explain the role of key gating amino acids and support some of the current gating hypotheses. These voltage-dependent protein changes include asymmetric barrel distortion, its interaction with the membrane, and significant displacement of N-α amino acids.

  9. Voltage Management in Unbalanced Low Voltage Networks Using a Decoupled Phase-Tap-Changer Transformer

    Coppo, Massimiliano; Turri, Roberto; Marinelli, Mattia


    The paper studies a medium voltage-low voltage transformer with a decoupled on load tap changer capability on each phase. The overall objective is the evaluation of the potential benefits on a low voltage network of such possibility. A realistic Danish low voltage network is used for the analysis...

  10. Estimating Voltage Asymmetry Making by One Phase Micro-generator in Low Voltage Network

    Marian Sobierajski


    Full Text Available Connection of one phase micro-generator to the low voltage network increases voltage asymmetry. The voltage asymmetry is defined as the quotient of negative and positive voltage components. The mathematical background of exact and rough computation of the asymmetry quotient is presented in the paper. Considerations are illustrated by simple examples.

  11. 76 FR 70721 - Voltage Coordination on High Voltage Grids; Notice of Staff Workshop


    ... Energy Regulatory Commission Voltage Coordination on High Voltage Grids; Notice of Staff Workshop Take notice that the Federal Energy Regulatory Commission will hold a Workshop on Voltage Coordination on High Voltage Grids on Thursday, December 1, 2011 from 9 a.m. to 4:30 p.m. This staff-led workshop will be...

  12. Improving transition voltage spectroscopy of molecular junctions

    Markussen, Troels; Chen, Jingzhe; Thygesen, Kristian Sommer


    Transition voltage spectroscopy (TVS) is a promising spectroscopic tool for molecular junctions. The principles in TVS is to find the minimum on a Fowler-Nordheim plot where ln(I/V2) is plotted against 1/V and relate the voltage at the minimum Vmin to the closest molecular level. Importantly, Vmin...... is approximately half the voltage required to see a peak in the dI/dV curve. Information about the molecular level position can thus be obtained at relatively low voltages. In this work we show that the molecular level position can be determined at even lower voltages, Vmin(α), by finding the minimum of ln...

  13. Piezo Voltage Controlled Planar Hall Effect Devices

    Zhang, Bao; Meng, Kang-Kang; Yang, Mei-Yin; Edmonds, K. W.; Zhang, Hao; Cai, Kai-Ming; Sheng, Yu; Zhang, Nan; Ji, Yang; Zhao, Jian-Hua; Zheng, Hou-Zhi; Wang, Kai-You


    The electrical control of the magnetization switching in ferromagnets is highly desired for future spintronic applications. Here we report on hybrid piezoelectric (PZT)/ferromagnetic (Co2FeAl) devices in which the planar Hall voltage in the ferromagnetic layer is tuned solely by piezo voltages. The change of planar Hall voltage is associated with magnetization switching through 90° in the plane under piezo voltages. Room temperature magnetic NOT and NOR gates are demonstrated based on the piezo voltage controlled Co2FeAl planar Hall effect devices without the external magnetic field. Our demonstration may lead to the realization of both information storage and processing using ferromagnetic materials.

  14. Piezo Voltage Controlled Planar Hall Effect Devices.

    Zhang, Bao; Meng, Kang-Kang; Yang, Mei-Yin; Edmonds, K W; Zhang, Hao; Cai, Kai-Ming; Sheng, Yu; Zhang, Nan; Ji, Yang; Zhao, Jian-Hua; Zheng, Hou-Zhi; Wang, Kai-You


    The electrical control of the magnetization switching in ferromagnets is highly desired for future spintronic applications. Here we report on hybrid piezoelectric (PZT)/ferromagnetic (Co2FeAl) devices in which the planar Hall voltage in the ferromagnetic layer is tuned solely by piezo voltages. The change of planar Hall voltage is associated with magnetization switching through 90° in the plane under piezo voltages. Room temperature magnetic NOT and NOR gates are demonstrated based on the piezo voltage controlled Co2FeAl planar Hall effect devices without the external magnetic field. Our demonstration may lead to the realization of both information storage and processing using ferromagnetic materials.

  15. Capacitor Voltages Measurement and Balancing in Flying Capacitor Multilevel Converters Utilizing a Single Voltage Sensor

    Farivar, Glen; Ghias, Amer M. Y. M.; Hredzak, Branislav


    This paper proposes a new method for measuring capacitor voltages in multilevel flying capacitor (FC) converters that requires only one voltage sensor per phase leg. Multiple dc voltage sensors traditionally used to measure the capacitor voltages are replaced with a single voltage sensor at the ac...... side of the phase leg. The proposed method is subsequently used to balance the capacitor voltages using only the measured ac voltage. The operation of the proposed measurement and balancing method is independent of the number of the converter levels. Experimental results presented for a five-level FC...

  16. Architecture, Voltage, and Components for a Turboelectric Distributed Propulsion Electric Grid

    Armstrong, Michael J.; Blackwelder, Mark; Bollman, Andrew; Ross, Christine; Campbell, Angela; Jones, Catherine; Norman, Patrick


    The development of a wholly superconducting turboelectric distributed propulsion system presents unique opportunities for the aerospace industry. However, this transition from normally conducting systems to superconducting systems significantly increases the equipment complexity necessary to manage the electrical power systems. Due to the low technology readiness level (TRL) nature of all components and systems, current Turboelectric Distributed Propulsion (TeDP) technology developments are driven by an ambiguous set of system-level electrical integration standards for an airborne microgrid system (Figure 1). While multiple decades' worth of advancements are still required for concept realization, current system-level studies are necessary to focus the technology development, target specific technological shortcomings, and enable accurate prediction of concept feasibility and viability. An understanding of the performance sensitivity to operating voltages and an early definition of advantageous voltage regulation standards for unconventional airborne microgrids will allow for more accurate targeting of technology development. Propulsive power-rated microgrid systems necessitate the introduction of new aircraft distribution system voltage standards. All protection, distribution, control, power conversion, generation, and cryocooling equipment are affected by voltage regulation standards. Information on the desired operating voltage and voltage regulation is required to determine nominal and maximum currents for sizing distribution and fault isolation equipment, developing machine topologies and machine controls, and the physical attributes of all component shielding and insulation. Voltage impacts many components and system performance.

  17. Effect of semiconductor-controlled voltage injection by UPFC and ULTC on power system stability

    Alavian Mehr, Alireza

    Commercial availability of various power semiconductor switches indicates proliferation of power electronic based apparatus in utility power systems. Furthermore, existing power system apparatus, e.g. mechanical phase shifters and mechanical tap changing transformers, will be retrofitted to utilize higher switching speed of semiconductor switches. A group of these apparatus, i.e., unified power flow controller (UPFC), static phase shifter (SPS), under-load tap-changing (ULTC) transformer and static series capacitor (SSC), perform their respective functions by means of injecting series controlled voltages in power systems. This thesis demonstrates that fast series voltage injection, for dynamic power flow regulation, can result in voltage dynamics and even voltage instability. This indicates that fast voltage injection by means of power electronic based apparatus can couple voltage stability and angle stability phenomena. To investigate this coupling phenomena, the voltage dependency of the load must be adequately represented in the load model. The reported studies in this work are based on representing the load by a combination of static and dynamic loads. This thesis primarily investigates impacts of UPFC and semiconductor-controlled ULTC on voltage stability and angle stability phenomena. An eigen analysis approach is used for the studies. The eigen analysis results are validated by digital time-domain simulations using a transient stability software. Both the eigen analysis and the transient stability software tools are tailored to account for angle and voltage stability phenomena.

  18. Voltage-controlled photonic oscillator.

    Savchenkov, A A; Ilchenko, V S; Liang, W; Eliyahu, D; Matsko, A B; Seidel, D; Maleki, L


    We report the development and demonstration of an X-band voltage-controlled photonic oscillator based on a whispering gallery mode resonator made of an electro-optic crystalline material. The oscillator has good spectral purity and wide, agile, linear tunability. We have modified the existing theoretical model of the opto-electronic oscillator to describe the performance of our tunable oscillator and have found a good agreement between the theoretical predictions and the measurement results. We show that the device is promising for higher-frequency applications where high-performance tunable oscillators with wide tunability do not exist.

  19. Voltage Management in Unbalanced Low Voltage Networks Using a Decoupled Phase-Tap-Changer Transformer

    Coppo, Massimiliano; Turri, Roberto; Marinelli, Mattia; Han, Xue


    The paper studies a medium voltage-low voltage transformer with a decoupled on load tap changer capability on each phase. The overall objective is the evaluation of the potential benefits on a low voltage network of such possibility. A realistic Danish low voltage network is used for the analysis. The load profiles are characterized by using single phase measurement data on voltages, currents and active powers with a 10 minutes resolution. Different scenarios are considered: no tap action, th...

  20. Negative Sequence Droop Method based Hierarchical Control for Low Voltage Ride-Through in Grid-Interactive Microgrids

    Zhao, Xin; Firoozabadi, Mehdi Savaghebi; Quintero, Juan Carlos Vasquez


    . In this paper, a voltage support strategy based on negative sequence droop control, which regulate the positive/negative sequence active and reactive power flow by means of sending proper voltage reference to the inner control loop, is proposed for the grid connected MGs to ride through voltage sags under...... complex line impedance conditions. In this case, the MGs should inject a certain amount of positive and negative sequence power to the grid so that the voltage quality at load side can be maintained at a satisfied level. A two layer hierarchical control strategy is proposed in this paper. The primary...... control loop consists of voltage and current inner loops, conventional droop control and virtual impedance loop while the secondary control loop is based on positive/negative sequence droop control which can achieve power injection under voltage sags. Experimental results with asymmetrical voltage sags...

  1. Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels.

    Tuluc, Petronel; Benedetti, Bruno; Coste de Bagneaux, Pierre; Grabner, Manfred; Flucher, Bernhard E


    Alternative splicing of the skeletal muscle CaV1.1 voltage-gated calcium channel gives rise to two channel variants with very different gating properties. The currents of both channels activate slowly; however, insertion of exon 29 in the adult splice variant CaV1.1a causes an ∼30-mV right shift in the voltage dependence of activation. Existing evidence suggests that the S3-S4 linker in repeat IV (containing exon 29) regulates voltage sensitivity in this voltage-sensing domain (VSD) by modulating interactions between the adjacent transmembrane segments IVS3 and IVS4. However, activation kinetics are thought to be determined by corresponding structures in repeat I. Here, we use patch-clamp analysis of dysgenic (CaV1.1 null) myotubes reconstituted with CaV1.1 mutants and chimeras to identify the specific roles of these regions in regulating channel gating properties. Using site-directed mutagenesis, we demonstrate that the structure and/or hydrophobicity of the IVS3-S4 linker is critical for regulating voltage sensitivity in the IV VSD, but by itself cannot modulate voltage sensitivity in the I VSD. Swapping sequence domains between the I and the IV VSDs reveals that IVS4 plus the IVS3-S4 linker is sufficient to confer CaV1.1a-like voltage dependence to the I VSD and that the IS3-S4 linker plus IS4 is sufficient to transfer CaV1.1e-like voltage dependence to the IV VSD. Any mismatch of transmembrane helices S3 and S4 from the I and IV VSDs causes a right shift of voltage sensitivity, indicating that regulation of voltage sensitivity by the IVS3-S4 linker requires specific interaction of IVS4 with its corresponding IVS3 segment. In contrast, slow current kinetics are perturbed by any heterologous sequences inserted into the I VSD and cannot be transferred by moving VSD I sequences to VSD IV. Thus, CaV1.1 calcium channels are organized in a modular manner, and control of voltage sensitivity and activation kinetics is accomplished by specific molecular mechanisms

  2. High-PSRR High-Order Curvature-Compensated CMOS Bandgap Voltage Reference

    Qianneng Zhou; Yunsong Li; Jinzhao Lin; Hongjuan Li; Yu Pang; Wei Luo


    A high⁃PSRR high⁃order curvature⁃compensated CMOS bandgap voltage reference (BGR), which has the performances of high power supply rejection ratio ( PSRR) and low temperature coefficient, is designed in SMIC 0�18 μm CMOS process. Compared to the conventional curvature⁃compensated BGR which adopted a piecewise⁃linear current, the temperature characterize of the proposed BGR is effectively improved by adopting two kinds of current including a piecewise⁃linear current and a current proportional 1�5 party to the absolute temperature T. By adopting a low dropout ( LDO) regulator whose output voltage is the operating supply voltage of the proposed BGR core circuit instead of power supply voltage VDD , the proposed BGR with LDO regulator achieves a well PSRR performance than the BGR without LDO regulator. Simulation results show that the proposed BGR with LDO regulator achieves a temperature coefficient of 2�1 × 10-6/℃ with a 1�8 V power supply voltage and a line regulation of 4�9 μV/V at 27 ℃. The proposed BGR with LDO regulator at 10 Hz, 100 Hz, 1 kHz, 10 kHz and 100 kHz have the PSRR of -106�388, -106�388, -106�38, -105�93 and-88�67 dB respectively.

  3. 49 CFR 236.551 - Power supply voltage; requirement.


    ... 49 Transportation 4 2010-10-01 2010-10-01 false Power supply voltage; requirement. 236.551 Section... supply voltage; requirement. The voltage of power supply shall be maintained within 10 percent of rated voltage....

  4. High Efficiency Interleaved Active Clamped Dc-Dc Converter with Fuel Cell for High Voltage Applications

    Sona P


    Full Text Available A high efficiency interleaved ZVS active clamped current fed dc-dc converter is proposed in this paper specially used for fuel cell applications. As the fuel cell output is very low we are in need of a step up dc-dc converter. Here a current fed dc-dc converter is used. Two current fed dc-dc converters are interleaved by connecting their inputs in parallel and outputs in series. With this proposed methodology input current ripples in the fuel cell stacks can be reduced and a regulated output voltage ripples can be obtained. The active clamping circuit used in this model absorbs the turn off voltage spikes hence low voltage devices with low on state resistance can be used.Voltage doubler circuits will give double the output voltage than normal with smaller transformer turns ratio and flexibility. The proposed method is simulated in MATLAB for verifying the accuracy of the proposed design.

  5. An improved control method of power electronic converters in low voltage micro-grid

    Xiaofeng, Sun; Qingqiu, Lv; Yanjun, Tian


    control of the voltage and frequency deviation added to power references could achieve secondary regulation of the voltage and frequency. In this paper, the authors take the steady and transient transition of grid connecting and disconnecting of the micro-grid as an example, and demonstrate...... the place. The conventional droop control can perform the energy management in grid-connected mode, but may not so effective when micro-grid transferring between grid-connected mode and island mode. The paper analysis the micro-grid in different modes (Conventional droop control, Voltage reference...... compensation, Constant power output mode, Phase adjustment mode), and then proposes an overall control strategy for the micro-grid. The voltage reference compensation would minimize the steady-state error on the nominated operation point; the coordinate control of voltage and frequency with a feed forward...

  6. On-chip high-voltage generator design design methodology for charge pumps

    Tanzawa, Toru


    This book provides various design techniques for switched-capacitor on-chip high-voltage generators, including charge pump circuits, regulators, level shifters, references, and oscillators.  Readers will see these techniques applied to system design in order to address the challenge of how the on-chip high-voltage generator is designed for Flash memories, LCD drivers, and other semiconductor devices to optimize the entire circuit area and power efficiency with a low voltage supply, while minimizing the cost.  This new edition includes a variety of useful updates, including coverage of power efficiency and comprehensive optimization methodologies for DC-DC voltage multipliers, modeling of extremely low voltage Dickson charge pumps, and modeling and optimum design of AC-DC switched-capacitor multipliers for energy harvesting and power transfer for RFID.

  7. PSO-Based Voltage Control Strategy for Loadability Enhancement in Smart Power Grids

    Heng-Yi Su


    Full Text Available This paper proposes a new voltage control methodology using the particle swarm optimization (PSO technique for smart grid loadability enhancement. The goal of this paper is to achieve reliable and efficient voltage profile/stability regulation in power grids. This methodology is based on the decouple power flow equations and the worst-case design technique. Specifically, the secondary voltage control (SVC problem is formulated as an L-infinity norm minimization problem which considers overall load voltage deviations in electrical power systems as an objective model, and the PSO technique is employed to determine a robust control action which aims to improve voltage profile and to enlarge transmission grid loadability by optimal coordinated control of VAR sources. The methodology was successfully tested on several IEEE benchmark systems.

  8. High voltage generator circuit with low power and high efficiency applied in EEPROM

    Liu Yan; Zhang Shilin; Zhao Yiqiang


    This paper presents a low power and high efficiency high voltage generator circuit embedded in electrically erasable programmable read-only memory (EEPROM).The low power is minimized by a capacitance divider circuit and a regulator circuit using the controlling clock switch technique.The high efficiency is dependent on the zero threshold voltage (Vth) MOSFET and the charge transfer switch (CTS) charge pump.The proposed high voltage generator circuit has been implemented in a 0.35μm EEPROM CMOS process.Measured results show that the proposed high voltage generator circuit has a low power consumption of about 150.48 μW and a higher pumping efficiency (83.3%) than previously reported circuits.This high voltage generator circuit can also be widely used in low-power flash devices due to its high efficiency and low power dissipation.

  9. Research on On-Line Coordinated Control Strategy to Improve the Voltage Vulnerability after Disturbance

    Qun-Ying Liu; Qi-Fang Liu; Deng Liu; Yong-Feng Liao


    The on-line coordinated control strategy among multi-voltage controls is important to keep voltage security in post-fault systems. Based on the wide area measuring information, the energy function, which can qualify the impacts of the different control actions on voltage of different nodes, is proposed. And then, considering the impacts of different control actions on the node voltage being treated as a weight matrix, the energy margin is used as the objective function and the reactive power margin is innovatively used as the constraint to regulate the control actions globally according to the weight values. At last, the objective functions are solved to get the optimal global coordinated control strategies. The proposed method is identified in an IEEE-30 Bus system and the simulation results show that it effectively improves the voltage stability.

  10. Low voltage driven dielectric electro active polymer actuator with integrated piezoelectric transformer based driver

    Andersen, Thomas; Rødgaard, Martin Schøler; Thomsen, Ole Cornelius


    Today’s Dielectric Electro Active Polymer (DEAP) actuators utilize high voltage (HV) in the range of kilo volts to fully stress the actuator. The requirement of HV is a drawback for the general use in the industry due to safety concerns and HV regulations. In order to avoid the HV interface to DEAP...... actuators, a low voltage solution is developed by integrating the driver electronic into a 110 mm tall cylindrical coreless Push InLastor actuator. To decrease the size of the driver, a piezoelectric transformer (PT) based solution is utilized. The PT is essentially an improved Rosen type PT...... with interleaved sections. Furthermore, the PT is optimized for an input voltage of 24 V with a gain high enough to achieve a DEAP voltage of 2.5 kV. The PT is simulated and verified through measurements on a working prototype. With the adapted hysteretic based control system; output voltage wave forms of both...

  11. Voltage-Independent Calcium Release in Heart Muscle

    Niggli, Ernst; Lederer, W. Jonathan


    The Ca2+ that activates contraction in heart muscle is regulated as in skeletal muscle by processes that depend on voltage and intracellular Ca2+ and involve a positive feedback system. How the initial electrical signal is amplified in heart muscle has remained controversial, however. Analogous protein structures from skeletal muscle and heart muscle have been identified physiologically and sequenced; these include the Ca2+ channel of the sarcolemma and the Ca2+ release channel of the sarcoplasmic reticulum. Although the parallels found in cardiac and skeletal muscles have provoked valuable experiments in both tissues, separation of the effects of voltage and intracellular Ca2+ on sarcoplasmic reticulum Ca2+ release in heart muscle has been imperfect. With the use of caged Ca2+ and flash photolysis in voltage-clamped heart myocytes, effects of membrane potential in heart muscle cells on Ca2+ release from intracellular stores have been studied. Unlike the response in skeletal muscle, voltage across the sarcolemma of heart muscle does not affect the release of Ca2+ from the sarcoplasmic reticulum, suggesting that other regulatory processes are needed to control Ca2+-induced Ca2+ release.

  12. Voltage-controlled Enzymes: The new Janus Bifrons

    Carlos Alberto Villalba-Galea


    Full Text Available The Ciona intestinalis voltage sensitive phosphatase, Ci-VSP, was the first Voltage-controlled Enzyme (VEnz proven to be under direct command of the membrane potential. The discovery of Ci-VSP conjugated voltage sensitivity and enzymatic activity in a single protein. These two facets of Ci-VSP activity have provided a unique model for studying how membrane potential is sensed by proteins and a novel mechanism for control of enzymatic activity. These facets make Ci-VSP a fascinating and versatile enzyme.Ci-VSP has a voltage sensing domain (VSD that resembles those found in voltage-gated channels (VGC. The VSD resides in the N-terminus and is formed by four putative trans-membrane segments. The fourth segment contains charged residues which are likely involved in voltage sensing. Ci-VSP produces sensing currents in response to changes in potential, within a defined range of voltages. Sensing currents are analogous to gating currents in VGC. As known, these latter proteins contain four VSDs which are entangled in a complex interaction with the pore domain –the effector domain in VGC. This complexity makes studying the basis of voltage sensing in VGC a difficult enterprise. In contrast, Ci-VSP is thought to be monomeric and its catalytic domain –the VSP’s effector domain– can be cleaved off without disrupting the basic electrical functioning of the VSD. For these reasons, VSPs are considered a great model for studying the activity of a VSD in isolation. Finally, VSPs are also phosphoinositide phosphatases. Phosphoinositides are signaling lipids found in eukaryotes and are involved in many processes, including modulation of VGC activity and regulation of cell proliferation. Understanding VSPs as VEnz has been the center of attention in recent years and several reviews has been dedicated to this area. Thus, this review will be focused instead on the other face of this true Janus Bifrons and recapitulate what is known about VSPs as electrically

  13. Voltage Unbalance Compensation with Smart Three-phase Loads

    Douglass, Philip; Trintis, Ionut; Munk-Nielsen, Stig


    voltage, but it does not reduce the negative sequence voltage. The controller that uses phase-phase voltage as input eliminates negative sequence voltage, and reduces voltage deviations from the average to approximately half their initial value. Current unbalance is reduced when the voltage unbalance...... is caused by asymmetrical loads. These results suggest that the optimal algorithm to reduce system unbalance depends on which system parameter is most important: phase-neutral voltage unbalance, phase-phase voltage unbalance, or current unbalance....

  14. Power conditioning using dynamic voltage restorers under different voltage sag types

    Ahmed M. Saeed


    Full Text Available Voltage sags can be symmetrical or unsymmetrical depending on the causes of the sag. At the present time, one of the most common procedures for mitigating voltage sags is by the use of dynamic voltage restorers (DVRs. By definition, a DVR is a controlled voltage source inserted between the network and a sensitive load through a booster transformer injecting voltage into the network in order to correct any disturbance affecting a sensitive load voltage. In this paper, modelling of DVR for voltage correction using MatLab software is presented. The performance of the device under different voltage sag types is described, where the voltage sag types are introduced using the different types of short-circuit faults included in the environment of the MatLab/Simulink package. The robustness of the proposed device is evaluated using the common voltage sag indices, while taking into account voltage and current unbalance percentages, where maintaining the total harmonic distortion percentage of the load voltage within a specified range is desired. Finally, several simulation results are shown in order to highlight that the DVR is capable of effective correction of the voltage sag while minimizing the grid voltage unbalance and distortion, regardless of the fault type.

  15. Power conditioning using dynamic voltage restorers under different voltage sag types.

    Saeed, Ahmed M; Abdel Aleem, Shady H E; Ibrahim, Ahmed M; Balci, Murat E; El-Zahab, Essam E A


    Voltage sags can be symmetrical or unsymmetrical depending on the causes of the sag. At the present time, one of the most common procedures for mitigating voltage sags is by the use of dynamic voltage restorers (DVRs). By definition, a DVR is a controlled voltage source inserted between the network and a sensitive load through a booster transformer injecting voltage into the network in order to correct any disturbance affecting a sensitive load voltage. In this paper, modelling of DVR for voltage correction using MatLab software is presented. The performance of the device under different voltage sag types is described, where the voltage sag types are introduced using the different types of short-circuit faults included in the environment of the MatLab/Simulink package. The robustness of the proposed device is evaluated using the common voltage sag indices, while taking into account voltage and current unbalance percentages, where maintaining the total harmonic distortion percentage of the load voltage within a specified range is desired. Finally, several simulation results are shown in order to highlight that the DVR is capable of effective correction of the voltage sag while minimizing the grid voltage unbalance and distortion, regardless of the fault type.

  16. Design and Evaluation of Autonomous Hybrid Frequency-Voltage Sensitive Load Controller

    Douglass, Philip James; Garcia-Valle, Rodrigo; Sossan, Fabrizio;


    The paper introduces an algorithm for control of autonomous loads without digital communication interfaces to provide both frequency regulation and voltage regulation services. This hybrid controller can be used to enhance frequency sensitive loads to mitigate line overload arising from reduced...

  17. Study on Optimization Strategy for Voltage and Reactive Power Control of Wind Farm

    Lu, Q.; Shi, L.; Chen, N.

    A method for calculating reactive power limit of wind farm comprised of doubly-fed induction generators (DFIG) is proposed. The reactive power limit of wind farm is the sum of reactive power limit of DFIGs which is calculated by the method considering static stability margin. Based on this, reactive power control of wind farm is discussed and proposed. The proposed reactive power control is divided into different control modes according to power factor of high voltage side in wind farm substation and voltage of low voltage side in point of interconnection(POI). In different control modes, different control objects are applied on reactive power regulation. After reactive power regulation is finished, some reactive power of wind farm should be released. At last, numerical test system is established, the result shows that the proposed method is effective to support voltage of POI

  18. Secondary Frequency and Voltage Control of Islanded Microgrids via Distributed Averaging

    W. Simpson-Porco, John; Shafiee, Qobad; Dorfler, Florian


    actions. The frequency controller rapidly regulates the microgrid frequency to its nominal value while maintaining active power sharing among the distributed generators. Tuning of the voltage controller provides a simple and intuitive trade-off between the conflicting goals of voltage regulation......In this work we present new distributed controllers for secondary frequency and voltage control in islanded microgrids. Inspired by techniques from cooperative control, the proposed controllers use localized information and nearest neighbour communication to collectively perform secondary control...... and reactive power sharing. Our designs require no knowledge of the microgrid topology, impedances or loads. The distributed architecture allows for flexibility and redundancy, and eliminates the need for a central microgrid controller. We provide a voltage stability analysis and present extensive experimental...

  19. High voltage load resistor array

    Lehmann, Monty Ray [Smithfield, VA


    A high voltage resistor comprising an array of a plurality of parallel electrically connected resistor elements each containing a resistive solution, attached at each end thereof to an end plate, and about the circumference of each of the end plates, a corona reduction ring. Each of the resistor elements comprises an insulating tube having an electrode inserted into each end thereof and held in position by one or more hose clamps about the outer periphery of the insulating tube. According to a preferred embodiment, the electrode is fabricated from stainless steel and has a mushroom shape at one end, that inserted into the tube, and a flat end for engagement with the end plates that provides connection of the resistor array and with a load.

  20. Voltage-Controlled Floating Resistor Using DDCC

    M. Kumngern


    Full Text Available This paper presents a new simple configuration to realize the voltage-controlled floating resistor, which is suitable for integrated circuit implementation. The proposed resistor is composed of three main components: MOS transistor operating in the non-saturation region, DDCC, and MOS voltage divider. The MOS transistor operating in the non-saturation region is used to configure a floating linear resistor. The DDCC and the MOS transistor voltage divider are used for canceling the nonlinear component term of MOS transistor in the non-saturation region to obtain a linear current/voltage relationship. The DDCC is employed to provide a simple summer of the circuit. This circuit offers an ease for realizing the voltage divider circuit and the temperature effect that includes in term of threshold voltage can be compensated. The proposed configuration employs only 16 MOS transistors. The performances of the proposed circuit are simulated with PSPICE to confirm the presented theory.

  1. Containment and Consensus-based Distributed Coordination Control for Voltage Bound and Reactive Power Sharing in AC Microgrid

    Han, Renke; Meng, Lexuan; Ferrari-Trecate, Giancarlo


    This paper offers a highly flexible and reliable control strategy to achieve voltage bounded regulation and accurate reactive power sharing coordinately in AC Micro-Grids. A containment and consensus-based distributed coordination controller is proposed, by which each output voltage magnitude can...

  2. Containment and Consensus-based Distributed Coordination Control for Voltage Bound and Reactive Power Sharing in AC Microgrid

    Han, Renke; Meng, Lexuan; Ferrari-Trecate, Giancarlo


    This paper offers a highly flexible and reliable control strategy to achieve voltage bounded regulation and accurate reactive power sharing coordinately in AC Micro-Grids. A containment and consensus-based distributed coordination controller is proposed, by which each output voltage magnitude can...

  3. Programable Driver for Voltage-Controlled Oscillators

    Fowler, L. E.; Mcneil, J. A.


    Electronically programable read-only memory (EPROM) and digital-to-analog converter provide customized time-varying voltage for frequency modulation. Voltage used to modulate IMPATT oscillator that serves as microwave pump for solid-state maser in low-noise amplifier. EPROM simple to tailor voltage waveform to suit characteristics of given maser. Digital information for waveform programed into EPROM chip; digital-to-analog converter reads information and produces corresponding analog wave. Principle readily adapted to other applications.

  4. Generator of ultrashort megavolt voltage pulses

    Zheltov, K A; Shalimanov, V F


    Paper describes approx 3 ns duration and > 1 MW amplitude voltage pulse generator under high-ohmic (approx 450 Ohm) load. Generator comprises pulse transformer with magnetized core, as well as, resonance tuned circuit of high-voltage solenoid and accumulating spaces of a shaping line containing, moreover, spark gap to switch charge in transmitting line. Paper contains the results of voltage measuring in generator basic units

  5. Investigation of pulsed voltage limiters characteristics

    Karimov A. V.


    Full Text Available A new method for measuring the voltage limit is offered. It has been designed to measure high-power pulsed current of voltage limiters. The error of this method is half as much as the error of the known method of direct measurement. The investigation of dependence of power capability of single-crystal and double-crystal voltage limiters and of the pulsed operation time on pulse duration.

  6. Voltage regulator placement in radial distribution system using plant ...


    Keywords: Plant Growth Simulation Algorithm (PGSA), Radial Distribution Systems (RDS), ... branches as well as load distribution and time variation and handles fast as a ... 1985a, 1985b and 1985c) deals with the determination of the optimal ..... that is called the preferential growth node will take priority of growing a new ...

  7. Performance analysis of voltage regulation in diesel-wind generation


    wind stream in the spin of the turbine the spin is the mechanical energy, now this mechanical energy is ... magnet synchronous generator is also their according to the electrical power generation these ..... Rotor flux component in q axis φdr.

  8. an improved voltage regulation of a distribution network using facts



    Jul 2, 2013 ... The analysis of this network was actualized using the conventional load flow equation modeling. ..... Figure 8: Flow chart of proposed flow control approach. Figure 9: Thirteen bus ... theft and technical losses. In this paper,.

  9. Modeling and Testing of Unbalanced Loading and Voltage Regulation

    Davis, M. W.; Broadwater, R.; Hambrick, J.


    This report covers work to (1) develop and validate distribution circuit models, (2) determine optimum distributed generator operating conditions, and (3) determine distributed generation penetration limits.

  10. Control Strategy for Three Phase Voltage Source PWM Rectifier Based on the Space Vector Modulation

    MILOUD, Y.


    Full Text Available This paper proposes the space vector pulse width modulation (SVPWM control scheme for three-phase voltage source PWM rectifier. The control system based on SVPWM includes two PI controllers which are used to regulate the AC currents and DC-link voltage. The proposed control can stabilize the minimum of the systems storage function at the desired equilibrium point determined by unity power factor and sinusoidal current on the AC side, and constant output voltage on the DC side. So the stable state performance and robustness against the load�s disturbance of PWM rectifiers are both improved. The simulation result shows feasibility of this strategy.

  11. Voltage Control Scheme for Three Phase SVM Inverter Fed Induction Motor Drive Systems



    Full Text Available This paper presents an efficient implementation scheme for the closed-loop voltage control of an induction motor incorporating ‘Space Vector Pulse Width Modulation (SVPWM‘. Voltage control is required to meet the variation in the input voltage and to regulate the output of the inverter. Space Vector Modulation (SVM is an algorithm for the control of Pulse Width Modulation (PWM. Comparative study has been made between SVM and PWM techniques. From the simulation results, SVM has reduced THD compared to pulse width modulation techniques. Thus, SVM gives better harmonic response and higher efficiency.

  12. Modeling and Simulation of the Single Phase Voltage Source UPS Inverter With Fourth Order Output Filter

    Javad Faiz


    Full Text Available A UPS inverter operates in wide load impedance ranges from resistive to capacitive or inductive load. At the same time, fast transient load response, good load regulation and good switching frequency suppression is required. The variation of the load impedance changes the filter transfer characteristic and thus the output voltage value. In this paper, an analysis and simulation of the single phase voltage source uninterruptible power supply (UPS with fourth order filter (multiple-filter in output inverter, based on the state space averaging and small signal linearization technique, is proposed. The simulation results show the high quality sinusoidal output voltage at different loads, with THD less than %5.

  13. Multi-Period Optimization for Voltage Control System in Transmission Grids

    Qin, Nan; Chen, Si; Liu, Chengxi


    Automatic Voltage Control (AVC) systems maintain the voltage in an acceptable range and minimize the power loss of the grid by coordinately regulating the controllable components. Switchable shunts and tap-able transformers are expected to be operated as few times as possible. This paper proposes....... In the lower level, the optimization is focused on the correction of the voltage violations every single minute based on data from the measurements and state estimation. The presented case study shows that the multi-period optimization in the upper level of AVC system can reduce adjustment times...

  14. Reactive Power Sharing and Voltage Harmonic Distortion Compensation of Droop Controlled Single Phase Islanded Microgrids

    Micallef, Alexander; Apap, Maurice; Spiteri-Staines, Cyril


    When paralleling multiple inverters that are capable of operating as an island, the inverters typically employ the droop control scheme. Traditional droop control enables the decentralized regulation of the local voltage and frequency of the microgrid by the inverters. The droop method also enables...... and reduction of the voltage harmonic distortion at the point of common coupling (PCC). Experimental results were then presented to show the suitability of the proposed algorithms in achieving reactive power sharing and in improving the voltage harmonic distortion at the PCC....

  15. Performance of Doubly-Fed Wind Power Generators During Voltage Dips

    Aparicio, N.; Chen, Zhe; Beltran, H.

    ) can regulate easily the reactive power generated in steady state. However, difficulties appear when reactive power has to be generated during voltage dips. Simulations have been carried out in order to check whether DFIG wind turbines can fulfill the reactive power requirements. Protection system......The growing of wind generation in Spain has forced its Transmission System Operator (TSO) to release new requirements that establish the amount of reactive power that a wind turbine has to supply to the grid during a voltage dip. Wind turbines equipped with doubly-fed induction generators (DFIG...... acting as STATCOM helps to improve the voltage profile sufficiently to permit rotor-side converter reconnection....

  16. Coordination of Voltage and Frequency Feedback in Load-Frequency Control Capability of Wind Turbine

    Hoseinzadeh, Bakhtyar; Silva, Filipe Faria Da; Bak, Claus Leth


    regulation. The proposed scheme demonstrates remarkable improvement transient state of both voltage and frequency profiles in comparison with conventional LFC designs provided by Central Power Plants (CPP) or Wind Power Plants (WPP). Numerical simulations carried out in DigSilent Power- Factory confirm......, sufficient reserve capacity should be procured. This paper addresses the Load-Frequency Control (LFC) scheme offered by VSWT. Feedback loop of locally measured voltage and frequency data is employed to improve transient and permanent response to achieve faster and more efficient LFC action and voltage...

  17. Low-Voltage Switched-Capacitor Circuits

    Bidari, E.; Keskin, M.; Maloberti, F.


    Switched-capacitor stages are described which can function with very low (typically 1 V) supply voltages, without using voltage boosting or switched op-amps. Simulations indicate that high performance may be achieved using these circuits in filter or data converter applications.......Switched-capacitor stages are described which can function with very low (typically 1 V) supply voltages, without using voltage boosting or switched op-amps. Simulations indicate that high performance may be achieved using these circuits in filter or data converter applications....

  18. Characterisation of the VELO High Voltage System

    Rakotomiaramanana, B; Eklund, L


    The high voltage system supplies the bias voltage to the 88 silicon sensors which comprise the LHCb Vertex Locator (VELO). This note describes the results of the tests which have been performed on the hardware of the high voltage system of the VELO. Each individual test detailed in this note corresponds to a specific requirement of the system. These requirements arise primarily from ensuring the safety of the silicon sensors and the quality of the data taken from the VELO modules. The tests performed are in four categories: normal operation of the high voltage system; vercation of its stability under operation; discussion of its behaviour in failure modes; and details of operation at low voltage. Noteworthy issues, identified through the tests, include the behaviour of the high voltage modules at voltages below 9V, the current limit that can be applied during ramping of the voltage, and the speed with which the voltage is cut during failures of the system. The results of these tests provide high confidence th...

  19. Characterisation of the VELO High Voltage System

    Rakotomiaramanana, B; Parkes, C; Eklund, L


    The high voltage system supplies the bias voltage to the 88 silicon sensors which comprise the LHCb Vertex Locator (VELO). This note describes the results of the tests which have been performed on the hardware of the high voltage system of the VELO. Each individual test detailed in this note corresponds to a specific requirement of the system. These requirements arise primarily from ensuring the safety of the silicon sensors and the quality of the data taken from the VELO modules. The tests performed are in four categories: normal operation of the high voltage system; verification of its stability under operation; discussion of its behaviour in failure modes; and details of operation at low voltage. Noteworthy issues, identified through the tests, include the behaviour of the high voltage modules at voltages below 9V, the current limit that can be applied during ramping of the voltage, and the speed with which the voltage is cut during failures of the system. The results of these tests provide high confidence...

  20. Microprocessor-controlled, programmable ramp voltage generator

    Hopwood, J.


    A special-purpose voltage generator has been developed for driving the quadrupole mass filter of a residual gas analyzer. The generator is microprocessor-controlled with desired ramping parameters programmed by setting front-panel digital thumb switches. The start voltage, stop voltage, and time of each excursion are selectable. A maximum of five start-stop levels may be pre-selected for each program. The ramp voltage is 0 to 10 volts with sweep times from 0.1 to 999.99 seconds.

  1. Magnetoelectric voltage coefficients of magnetoelectric composites

    WAN Yong-ping; ZHONG Zheng; QIU Jin-hao


    The magnetoelectric(ME) effect of the particulate magnetostrictive/piezoelectric composite was theoretically studied. The dependence of the ME voltage coefficients on the material properties of the magnetostrictive phase was discussed. The permittivity,permeability and the elastic modulus of the magnetostrictive phase generally have obvious influences on the ME voltage coefficients. The magnetostrictive phase with a large permittivity,large permeability or stiffer modulus will respectively contribute to the higher ME voltage coefficients. For a certain kind of piezoelectric matrix,the ME voltage coefficients can be improved to some extent by choosing those magnetostrictive materials with large permittivity,permeability or high elastic modulus.

  2. Maximum permissible voltage of YBCO coated conductors

    Wen, J.; Lin, B.; Sheng, J.; Xu, J.; Jin, Z. [Department of Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China); Hong, Z., E-mail: [Department of Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China); Wang, D.; Zhou, H.; Shen, X.; Shen, C. [Qingpu Power Supply Company, State Grid Shanghai Municipal Electric Power Company, Shanghai (China)


    Highlights: • We examine three kinds of tapes’ maximum permissible voltage. • We examine the relationship between quenching duration and maximum permissible voltage. • Continuous I{sub c} degradations under repetitive quenching where tapes reaching maximum permissible voltage. • The relationship between maximum permissible voltage and resistance, temperature. - Abstract: Superconducting fault current limiter (SFCL) could reduce short circuit currents in electrical power system. One of the most important thing in developing SFCL is to find out the maximum permissible voltage of each limiting element. The maximum permissible voltage is defined as the maximum voltage per unit length at which the YBCO coated conductors (CC) do not suffer from critical current (I{sub c}) degradation or burnout. In this research, the time of quenching process is changed and voltage is raised until the I{sub c} degradation or burnout happens. YBCO coated conductors test in the experiment are from American superconductor (AMSC) and Shanghai Jiao Tong University (SJTU). Along with the quenching duration increasing, the maximum permissible voltage of CC decreases. When quenching duration is 100 ms, the maximum permissible of SJTU CC, 12 mm AMSC CC and 4 mm AMSC CC are 0.72 V/cm, 0.52 V/cm and 1.2 V/cm respectively. Based on the results of samples, the whole length of CCs used in the design of a SFCL can be determined.

  3. Inductive voltage divider modeling in Matlab

    Andreev, S. A.; Kim, V. L.


    Inductive voltage dividers have the most appropriate metrological characteristics on alternative current and are widely used for converting physical signals. The model of a double-decade inductive voltage divider was designed with the help of Matlab/Simulink. The first decade is an inductive voltage divider with balanced winding, the second decade is a single-stage inductive voltage divider. In the paper, a new transfer function algorithm was given. The study shows errors and differences that appeared between the third degree reduced model and a twenty degree unreduced model. The obtained results of amplitude error differ no more than by 7 % between the reduced and unreduced model.

  4. Development of a voltage scanner of chopper

    Shen Guan Ren; LiShengLi; WangQuanXing; Wu Long Cheng


    Development of voltage sweeper of chopper with CPNG are introduced. Voltage sweeper is one of important key parts of chopper. Two years working prove that it is stable and reliable. Its main technology performance save: sine wave frequency: 750 kHz +- 20 Hz; total distortion: 65 Db; output voltage (V-V): 0->=4000 V; the error7 W; voltage supply: 220V AC +-10%, 50 +- 1 Hz; total power supply: <100W; Work temperature range: 0 - 40 degree; Stability in long time <=1%

  5. Voltage-independent inhibition of Cav2.2 channels is delimited to a specific region of the membrane potential in rat SCG neurons

    Oscar Vivas; Isabel Arenas; David E.García


    Neurotransmitters and hormones regulate Cav2.2 channels through a voltage-independent pathway which is not well understood.It has been suggested that this voltageindependent inhibition is constant at all membrane voltages.However,changes in the percent of voltageindependent inhibition of Cav2.2 have not been tested within a physiological voltage range.Here,we used a double-pulse protocol to isolate the voltage-independent inhibition of Cav2.2 channels induced by noradrenaline in rat superior cervical ganglion neurons.To assess changes in the percent of the voltage-independent inhibition,the activation voltage of the channels was tested between -40 and +40 mV.We found that the percent of voltage-independent inhibition induced by noradrenaline changed with the activation voltage used.In addition,voltage-independent inhibition induced by oxo-M,a muscarinic agonist,exhibited thesame dependence on activation voltage,which supports that this pattern is not exclusive for adrenergic activation.Our results suggested that voltage-independent inhibition of Cav2.2 channels depends on the activation voltage of the channel in a physiological voltage range.This may have relevant implications in the understanding of the mechanism involved in voltage-independent inhibition.

  6. An ANN Based Capicitor Voltage Balancing Method For Neutral Point Clamped Multi-Level Inverter

    P.J.S. Praveen,


    Full Text Available Multi-level inverters are became popular for usage in medium voltage, low voltage power applications due to flexibility in control and better performance characteristics in terms of harmonic regulation. Neutral point clamped are popular as they require less number of sources as their input when compared with their counter parts i.e. cascaded multi-level inverters and found to be reliable when compared with flying capacitor based multi-level inverters. But when neutral clamped technologies are used for generation of three-phase voltages, the capacitors that are connected at input side experiences imbalance in their voltages, this makes neutral point clamped multi-level inverters less reliable. In the proposed work an attempt is made to study circuits that balances the capacitor voltages and a scheme is investigated for balancing the capacitor voltages. Method proposed in [1] uses PID controller for balancing the capacitor voltages. In this project PI based control scheme and artificial neural network (ANN based control scheme for the front end circuit shown in [1] are designed for achieving balance among the capacitor voltages. The proposed control scheme is simulated with the help of Simpowersystems block set and neural network toolbox of MATLAB software for different load conditions. Results obtained from ANN based controller and PI controller are presented.

  7. Voltage Control Method Using Distributed Generators Based on a Multi-Agent System

    Hyun-Koo Kang


    Full Text Available This paper presents a voltage control method using multiple distributed generators (DGs based on a multi-agent system framework. The output controller of each DG is represented as a DG agent, and each voltage-monitoring device is represented as a monitoring agent. These agents cooperate to accomplish voltage regulation through a coordinating agent or moderator. The moderator uses the reactive power sensitivities and margins to determine the voltage control contributions of each DG. A fuzzy inference system (FIS is employed by the moderator to manage the decision-making process. An FIS scheme is developed and optimized to enhance the efficiency of the proposed voltage control process using particle swarm optimization. A simple distribution system with four voltage-controllable DGs is modeled, and an FIS moderator is implemented to control the system. Simulated data show that the proposed voltage control process is able to maintain the system within the operating voltage limits. Furthermore, the results were similar to those obtained using optimal power flow calculations, even though little information on the power system was required and no power flow calculations were implemented.

  8. Voltage-Gated Calcium Channels in Nociception

    Yasuda, Takahiro; Adams, David J.

    Voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of membrane ion channels ubiquitously expressed throughout the central and peripheral nervous systems. VGCCs contribute to various physiological processes and transduce electrical activity into other cellular functions. This chapter provides an overview of biophysical properties of VGCCs, including regulation by auxiliary subunits, and their physiological role in neuronal functions. Subsequently, then we focus on N-type calcium (Cav2.2) channels, in particular their diversity and specific antagonists. We also discuss the role of N-type calcium channels in nociception and pain transmission through primary sensory dorsal root ganglion neurons (nociceptors). It has been shown that these channels are expressed predominantly in nerve terminals of the nociceptors and that they control neurotransmitter release. To date, important roles of N-type calcium channels in pain sensation have been elucidated genetically and pharmacologically, indicating that specific N-type calcium channel antagonists or modulators are particularly useful as therapeutic drugs targeting chronic and neuropathic pain.

  9. Excitation of voltage oscillations in an induction voltage adder

    Nichelle Bruner


    Full Text Available The induction voltage adder is an accelerator architecture used in recent designs of pulsed-power driven x-ray radiographic systems such as Sandia National Laboratories’ Radiographic Integrated Test Stand (RITS, the Atomic Weapons Establishment’s planned Hydrus Facility, and the Naval Research Laboratory’s Mercury. Each of these designs relies on magnetic insulation to prevent electron loss across the anode-cathode gap in the vicinity of the adder as well as in the coaxial transmission line. Particle-in-cell simulations of the RITS adder and transmission line show that, as magnetic insulation is being established during a pulse, some electron loss occurs across the gap. Sufficient delay in the cavity pulse timings provides an opportunity for high-momentum electrons to deeply penetrate the cavities of the adder cells where they can excite radio-frequency resonances. These oscillations may be amplified in subsequent gaps, resulting in oscillations in the output power. The specific modes supported by the RITS-6 accelerator and details of the mechanism by which they are excited are presented in this paper.

  10. Containment and Consensus-based Distributed Coordination Control to Achieve Bounded Voltage and Precise Reactive Power Sharing in Islanded AC Microgrids

    Han, Renke; Meng, Lexuan; Ferrari-Trecate, Giancarlo


    This paper presents a novel distributed approach to achieve both bounded voltage and accurate reactive power sharing regulation in AC microgrid. The coupling/trade-off effects between bus voltages and reactive power sharing regulation are first analyzed in detail to provide a guideline for coordi...

  11. Automatic Voltage Control (AVC) of Danish Transmission System - Concept design

    Qin, Nan; Abildgaard, Hans; Lund, P.


    , objectives, constraints, algorithms for optimal power flow and some special functions in particular systems, which inspires the concept design of a Danish AVC system to address the future challenges of voltage control. In the concept, the Danish AVC design is based on a centralized control scheme. All....... Another consequence is the public way of generally thinking green which have led to a national decision of undergrounding not only all of the Danish distribution system but also the future transmission system. These issues initiate the infrastructure constructions of the transmission system i.e. a large...... the substation loses the telecommunications to the control center. RPCs will be integrated to the AVC system as normative regulators in the later stage. Distributed generation units can be organized as virtual power plants and participate in voltage control at transmission level. as the Danish TSO...

  12. Neuronal trafficking of voltage-gated potassium channels

    Jensen, Camilla S; Rasmussen, Hanne Borger; Misonou, Hiroaki


    The computational ability of CNS neurons depends critically on the specific localization of ion channels in the somatodendritic and axonal membranes. Neuronal dendrites receive synaptic inputs at numerous spines and integrate them in time and space. The integration of synaptic potentials....... The physiological significance of proper Kv channel localization is emphasized by the fact that defects in the trafficking of Kv channels are observed in several neurological disorders including epilepsy. In this review, we will summarize the current understanding of the mechanisms of Kv channel trafficking...... is regulated by voltage-gated potassium (Kv) channels, such as Kv4.2, which are specifically localized in the dendritic membrane. The synaptic potentials eventually depolarize the membrane of the axon initial segment, thereby activating voltage-gated sodium channels to generate action potentials. Specific Kv...

  13. Intelligent distributed voltage control system for smart grid application

    Sajadi, Amirhossein [Warsaw Univ. of Technology (Poland); Ariatabar, Mitra [RWTH Aachen Univ. (Germany)


    Increasing penetration of the renewable energy source (RES) units in distribution networks particularly due to nonlinear and unpredictable nature of renewable units brings up new challenges in different aspects of electricity network, which leads to more complex power systems. Multi-agent system is consisting of agents which are capable to perceive environment that they are located in and to reacts with each other by communication infrastructure in order to achieve overall goals. In this paper an approach to control the voltage based on in the power distribution system is proposed and discussed. Therefore, a multi-agent system has been integrated with artificial intelligence to come up with fuzzy multi-agent based system. The proposed control scheme is deployed to a smart distribution system consisting distribution generation units, modelled in MATLAB/Simulink, to evaluate its effectiveness. The simulation results show how proposed system can regulate voltage in smart distribution feeders. (orig.)

  14. An ultra-low noise, high-voltage piezo driver

    Pisenti, N C; Reschovsky, B J; Barker, D S; Campbell, G K


    We present an ultra-low noise, high-voltage driver suited for use with piezoelectric actuators and other low-current applications. The architecture uses a flyback switching regulator to generate up to 250V in our current design, with an output of 1 kV or more possible with small modifications. A high slew-rate op-amp suppresses the residual switching noise, yielding a total RMS noise of $\\approx 100\\mu$V (1 Hz--100 kHz). A low-voltage ($\\pm 10$V), high bandwidth signal can be summed with unity gain directly onto the output, making the driver well-suited for closed-loop feedback applications. Digital control enables both repeatable setpoints and sophisticated control logic, and the circuit consumes less than 150mA at $\\pm 15$V.

  15. Implementation strategy for soft switching PFC with low output voltage


    This paper proposes a novel implementation strategy for soft switching PFC whose circuit is simple and can achieve low voltage output directly. The main circuit adopts current mode full-bridge converter and all the power switches can realize ZCS or ZVS in the way of phase-shifted control, using the leakage inductance of the transformer, the junction capacitor of the switches and the stored energy of the output capacitor. The problems such as the function of phase-shifted link in control circuit, the implementation conditions of soft switching and bias restrained are analyzed. The adoption of constant frequency PWM control makes the design of the input and output filter link and the high frequency transformer simple. The transformation ratio regulation so as to achieve low voltage output and electrical insulation can be realized by using high frequency transformer.

  16. Modeling and Design of DC Boost and AC Side Voltage Controllers in Asymmetrical Γ-Source Inverter


    In this paper a control system is proposed to simultaneously control the voltage boost and output voltage of assymetrical Γ-Source Inverters. Dynamic model of the system is used to design the controllers. Voltage boost on assymetrical Γ-Source Inverters is done by voltage control of impedance network capacitor and the regulation of inverter shoot through duty cycle. Since the stability margin of the system is low due to the right half plane zero in its dynamic model, the design of fast contro...

  17. Investigation on a Novel Discontinuous Pulse-Width Modulation Algorithm for Single-phase Voltage Source Rectifier

    Qu, Hao; Yang, Xijun; Guo, Yougui


    -sequence component injection, in order to reduce power loss and increased overall efficiency. And then by reconstructing the other two phase input voltages and currents, the transformation from stationary frame (abc) to rotating frame (dq frame) is designed. Finally, a PI regulator based controller for single......Single-phase voltage source converter (VSC) is an important power electronic converter (PEC), including single-phase voltage source inverter (VSI), single-phase voltage source rectifier (VSR), single-phase active power filter (APF) and single-phase grid-connection inverter (GCI). Single-phase VSC...

  18. Influence of current limitation on voltage stability with voltage sourced converter HVDC

    Zeni, Lorenzo; Jóhannsson, Hjörtur; Hansen, Anca Daniela;


    A first study of voltage stability with relevant amount of Voltage Sourced Converter based High Voltage Direct Current (VSC-HVDC) transmission is presented, with particular focus on the converters’ behaviour when reaching their rated current. The detrimental effect of entering the current...

  19. Voltage stability in low voltage microgrids in aspects of active and reactive power demand

    Parol Mirosław


    Full Text Available Low voltage microgrids are autonomous subsystems, in which generation, storage and power and electrical energy consumption appear. In the paper the main attention has been paid to the voltage stability issue in low voltage microgrid for different variants of its operation. In the introduction a notion of microgrid has been presented, and also the issue of influence of active and reactive power balance on node voltage level has been described. Then description of voltage stability issue has been presented. The conditions of voltage stability and indicators used to determine voltage stability margin in the microgrid have been described. Description of the low voltage test microgrid, as well as research methodology along with definition of considered variants of its operation have been presented further. The results of exemplary calculations carried out for the daily changes in node load of the active and reactive power, i.e. the voltage and the voltage stability margin indexes in nodes have been presented. Furthermore, the changes of voltage stability margin indexes depending on the variant of the microgrid operation have been presented. Summary and formulation of conclusions related to the issue of voltage stability in microgrids have been included at the end of the paper.

  20. Reduced Voltage Scaling in Clock Distribution Networks

    Khader Mohammad


    Full Text Available We propose a novel circuit technique to generate a reduced voltage swing (RVS signals for active power reduction on main buses and clocks. This is achieved without performance degradation, without extra power supply requirement, and with minimum area overhead. The technique stops the discharge path on the net that is swinging low at a certain voltage value. It reduces active power on the target net by as much as 33% compared to traditional full swing signaling. The logic 0 voltage value is programmable through control bits. If desired, the reduced-swing mode can also be disabled. The approach assumes that the logic 0 voltage value is always less than the threshold voltage of the nMOS receivers, which eliminate the need of the low to high voltage translation. The reduced noise margin and the increased leakage on the receiver transistors using this approach have been addressed through the selective usage of multithreshold voltage (MTV devices and the programmability of the low voltage value.