WorldWideScience

Sample records for regulators dod generators

  1. Voltage regulator for generator

    Energy Technology Data Exchange (ETDEWEB)

    Naoi, K

    1989-01-17

    It is an object of this invention to provide a voltage regulator for a generator charging a battery, wherein even if the ambient temperature at the voltage regulator rises abnormally high, possible thermal breakage of the semiconductor elements constituting the voltage regulator can be avoided. A feature of this invention is that the semiconductor elements can be protected from thermal breakage, even at an abnormal ambient temperature rise at the voltage regulator for the battery charging generator, by controlling a maximum conduction ratio of a power transistor in the voltage regulator in accordance with the temperature at the voltage regulator. This is achieved through a switching device connected in series to the field coil of the generator and adapted to be controlled in accordance with an output voltage of the generator and the ambient temperature at the voltage regulator. 6 figs.

  2. 76 FR 57671 - Defense Federal Acquisition Regulation Supplement; Display of DoD Inspector General Fraud Hotline...

    Science.gov (United States)

    2011-09-16

    ... the title of the applicable Department of Homeland Security (DHS) fraud hotline poster and Web site(s... General Fraud Hotline Posters AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... Regulation Supplement (DFARS) to require contractors to display the DoD fraud hotline poster in common work...

  3. 77 FR 2682 - Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing

    Science.gov (United States)

    2012-01-19

    ... provisional payment and sent to the disbursing office after a pre- payment review. Interim vouchers not... after a pre-payment review. Interim vouchers not selected for a pre-payment review will be considered to...] RIN 0750-AH52 Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing AGENCY...

  4. 75 FR 54527 - Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels...

    Science.gov (United States)

    2010-09-08

    ...-AG50 Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels.... Section 825 clarifies the Government's rights in technical data in the designs of a DoD vessel, boat... cite DFARS Case 2008-D039. SUPPLEMENTARY INFORMATION: A. Background This final rule implements section...

  5. Regulating services as measures of ecological resilience on DoD lands

    Science.gov (United States)

    Angermeier, Paul; Villamagna, Amy M.

    2015-01-01

    Knowledge of the capacity and flow of ecosystem services can help DoD land managers make decisions that enhance cost-effectiveness, minimize environmental damage, and maximize resources available for military missions. We demonstrated a methodology to quantify and map selected regulating services (RS), which helps land managers envision tradeoffs. Our objectives were to 1) estimate current capacity of and demand for selected RS within DoD lands, 2) examine the effects of future DoD land management and climate changes on the capacity and flow of these RS, and 3) project how land-use and climate changes in nearby lands affect future demand for RS. Our approach incorporates widely accepted models and equations, remote sensing, GIS analysis, and stakeholder involvement. Required data include land cover/use, soil type, precipitation, and air temperature. We integrated data into the a) Surface Curve Number Method and b) Revised Universal Soil Loss Equation to estimate capacity of sediment, nitrogen (N) and surface-water regulation. Capacities and flows of RS vary greatly across landscapes and are likely to vary as climate changes or development occurs. Analyses of RS capacity and flow can help managers and planners prioritize actions in the context of best management practices and compatible use buffers. Staff surveys indicated that our approach was informative and easy to use. Implementation may be most limited by on-installation personnel time.

  6. 32 CFR 37.130 - Which other parts of the DoD Grant and Agreement Regulations apply to TIAs?

    Science.gov (United States)

    2010-07-01

    ... Regulations apply to TIAs? 37.130 Section 37.130 National Defense Department of Defense OFFICE OF THE... Which other parts of the DoD Grant and Agreement Regulations apply to TIAs? (a) TIAs are explicitly... information about assistance awards. (b) Two additional parts of the DoDGARs apply to TIAs, although they do...

  7. 76 FR 13327 - Defense Federal Acquisition Regulation Supplement; Display of DoD Inspector General Fraud Hotline...

    Science.gov (United States)

    2011-03-11

    ..., Washington, DC 22202-2884. (ii) Department of Homeland Security (DHS) fraud hotline poster identified in... _________ _________ _________ _________ (Contracting Officer shall insert-- (i) Title of applicable Department of Homeland Security fraud hotline...-AG98 Defense Federal Acquisition Regulation Supplement; Display of DoD Inspector General Fraud Hotline...

  8. 76 FR 66889 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified DoD Information...

    Science.gov (United States)

    2011-10-28

    ...). ACTION: Notice of meeting. SUMMARY: DoD is hosting a public meeting to initiate a dialogue with industry... not presently address the safeguarding of unclassified DoD information within industry, nor does it... processed through security in a timely fashion. Prior registrants will be given priority if room constraints...

  9. DOD Open Government

    Science.gov (United States)

    increase transparency and openness. We encourage you to explore other information on our website to learn Defense Search DOD Open Government: Home Open Government @ DoD Transparency Congressional Inquiries IT Dashboard.gov Regulations.gov Challenge.gov Performance.gov ForeignAssistance.gov Transparency

  10. Designing Next Generation Telecom Regulation

    DEFF Research Database (Denmark)

    Henten, Anders; Samarajiva, Rohan

    – ICT convergence regulation and multisector utility regulation. Whatever structure of next generation telecom regulation is adopted, all countries will need to pay much greater attention to the need for increased coordination of policy directions and regulatory activities both across the industries......Continuously expanding applications of information and communication technologies (ICT) are transforming local, national, regional and international economies into network economies, the foundation for information societies. They are being built upon expanded and upgraded national telecom networks...... to creating an environment to foster a massive expansion in the coverage and capabilities of the information infrastructure networks, with national telecom regulators as the key implementers of the policies of reform. The first phase of reform has focused on industry specific telecom policy and regulation...

  11. 76 FR 38089 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified DoD Information...

    Science.gov (United States)

    2011-06-29

    ... Defense Contract Audit Agency audit; (ii) By DoD Offices of the Inspector General as part of pending or on...-3 MA-4(6) SC-4. AC-3(4) Audit & Identification and MA-5 SC-7. Accountability. Authentication. AC-4... determined). [[Page 38095

  12. Industrial Processes to Reduce Generation of Hazardous Waste at DoD facilities. Phase Report. Appendix A

    Science.gov (United States)

    1985-12-01

    by CLEMCO, Pauli & helps to stress - releive the surfaces, Griffin, CAB Systems and Royce does not heal cracks in aluminum and Mechanical Systems are now...Generation of HlazardOuIs Waste at DoD Facilities- 1.S)3 Re.port 2 PERSONAL AUTHOR(S) Ia lYE OF REPOR I Jb TIME COVERED 14. DATE OF REPORT (Year...105 miles from Hill AFB on the north slope. of the Ulntah Mountains. (For military and family members and retired military and family members only

  13. Designing Next Generation Telecom Regulation

    DEFF Research Database (Denmark)

    Henten, Anders; Samarajiva, Rohan; Melody, William H.

    2003-01-01

    This article critically examines the multiple rationales for telecom, IT, media convergence regulation, on the one hand, and multisector utility regulation, on the other, and the practical questions of implementation they pose, with a view to contributing to informed policy and regulatory decisions...... to the regulatory process such as scarcity of regulatory resources and safeguards for regulatory independence, are examined. It is concluded that ICT and media convergence issues are primarily about improving the efficiency of market economies, and how changes in regulation can facilitate this process. Multi...

  14. Regulation of ageing steam generators

    International Nuclear Information System (INIS)

    Jarman, B.L.; Grant, I.M.; Garg, R.

    1998-01-01

    Recent years have seen leaks and shutdowns of Canadian CANDU plants due to steam generator tube degradation by mechanisms including stress corrosion cracking, fretting and pitting. Failure of a single steam generator tube, or even a few tubes, would not be a serious safety related event in a CANDU reactor. The leakage from a ruptured tube is within the makeup capacity of the primary heat transport system, so that as long as the operator takes the correct actions, the off-site consequences will be negligible. However, assurance that no tubes deteriorate to the point where their integrity could be seriously breached as result of potential accidents, and that any leakage caused by such an accident will be small enough to be inconsequential, can only be obtained through detailed monitoring and management of steam generator condition. This paper presents the AECB's current approach and future regulatory directions regarding ageing steam generators. (author)

  15. Internal Controls and Compliance with Laws and Regulations for the DOD Military Retirement Trust Fund Financial Statements for FY 1995

    National Research Council Canada - National Science Library

    1996-01-01

    The objective of the audit was to determine whether the DoD Military Retirement Trust Fund Financial Statements for FY 1995 were fairly presented in accordance with Office of Management and Budget Bulletin...

  16. Internal Controls and Compliance with Laws and Regulations for the DOD Military Retirement Trust Fund Financial Statements for FY 1996

    National Research Council Canada - National Science Library

    Lane, F

    1997-01-01

    The objective of the audit was to determine whether the DoD Military Retirement Trust Fund Financial Statements for FY 1996 were fairly presented in accordance with Office of Management and Budget Bulletin...

  17. Business Models and Regulation | Distributed Generation Interconnection

    Science.gov (United States)

    Collaborative | NREL Business Models and Regulation Business Models and Regulation Subscribe to new business models and approaches. The growing role of distributed resources in the electricity system is leading to a shift in business models and regulation for electric utilities. These

  18. Internal Controls and Compliance with Laws and Regulations for the DOD Military Retirement Trust Fund Financial Statements for FY 1995

    National Research Council Canada - National Science Library

    1996-01-01

    ... No. 94-01, "Form and Content of Agency Financial Statements," November 16, 1993. In addition, we assessed the internal controls and compliance with laws and regulations related to the financial statements...

  19. Internal Controls and Compliance with Laws and Regulations for the DOD Military Retirement Trust Fund Financial Statements for FY 1996

    National Research Council Canada - National Science Library

    Lane, F

    1997-01-01

    ... No. 94-01, "Form and Content of Agency Financial Statements," November 16, 1993. In addition, we assessed the internal controls and compliance with laws and regulations related to the financial statements...

  20. Evaluation of the Navy Implementation of DOD Financial Management Regulation, Volume 14, Administrative Control of Funds and Antideficiency Act Violations

    National Research Council Canada - National Science Library

    Lane, F

    1996-01-01

    On August 1, 1995, the Under Secretary of Defense (Comptroller) released for implementation Financial Management Regulation, volume 14, "Administrative Control of Funds and Antideficiency Act Violations," August 1, 1995...

  1. Optimal Management of DoD Lands for Military Training, Ecosystem Services, and Renewable Energy Generation: Framework and Data Requirements

    Science.gov (United States)

    2013-01-01

    published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/ client /default. Base Facilities Environmental Quality ERDC/CERL TR...generation—on the primary land-management driver, the military training. 1.3 Approach The modeling framework was developed to generate a Pareto

  2. 75 FR 59101 - Defense Federal Acquisition Regulation Supplement; DoD Office of the Inspector General Address...

    Science.gov (United States)

    2010-09-27

    ....203-13, Contractor Code of Business Ethics and Conduct. DATES: Effective Date: September 27, 2010. FOR... Acquisition Regulation (FAR) Case 2007-006, ``Contractor Business Ethics Compliance Program and Disclosure... date of December 12, 2008. The contract clause entitled ``Contractor Code of Business Ethics and...

  3. Analysis of the Air Force ISO 14001 Pilot Study Conducted by DoD

    National Research Council Canada - National Science Library

    Harris, Rodney

    2000-01-01

    The Department of Defense (DoD) conducted an ISO 14001 pilot study with the primary goal of determining how ISO 14001 could help DoD organizations reduce risks, improve compliance with environmental regulations, enhance stewardship...

  4. A self-regulating hydrogen generator for micro fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Moghaddam, Saeed; Pengwang, Eakkachai; Shannon, Mark A. [Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 West Green Street, Urbana, IL 61801 (United States); Masel, Richard I. [Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 213 Roger Adams Lab, 600 S. Mathews, Urbana, IL 61801 (United States)

    2008-10-15

    The ever-increasing power demands and miniaturization of portable electronics, micro-sensors and actuators, and emerging technologies such as cognitive arthropods have created a significant interest in development of micro fuel cells. One of the major challenges in development of hydrogen micro fuel cells is the fabrication and integration of auxiliary systems for generating, regulating, and delivering hydrogen gas to the membrane electrode assembly (MEA). In this paper, we report the development of a hydrogen gas generator with a micro-scale control system that does not consume any power. The hydrogen generator consists of a hydride reactor and a water reservoir, with a regulating valve separating them. The regulating valve consists of a port from the water reservoir and a movable membrane with via holes that permit water to flow from the reservoir to the hydride reactor. Water flows towards the hydride reactor, but stops within the membrane via holes due to capillary forces. Water vapor then diffuses from the via holes into the hydride reactor resulting in generation of hydrogen gas. When the rate of hydrogen consumed by the MEA is lower than the generation rate, gas pressure builds up inside the hydride reactor, deflecting the membrane, closing the water regulator valve, until the pressure drops, whereby the valve reopens. We have integrated the self-regulating micro hydrogen generator to a MEA and successfully conducted fuel cell tests under varying load conditions. (author)

  5. DoD ESI

    Science.gov (United States)

    awarded BPAs to DLT Solutions, LLC, EC America, Inc., and International Systems Marketing, Inc. for the Information Management, Microsoft Platform Management, Identity & Access Management, Endpoint Systems Management, Data Protection, Performance Monitoring and Support in support of the DoD mission.Click here for

  6. NRC licensing requirements: DOD options

    International Nuclear Information System (INIS)

    Pike, W.J.; O'Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with 90 Sr or 238 Pu; radioisotopic dynamic electric generators with 90 Sr or 238 Pu; and applications of radioisotopes for luminous sources (lights) with 3 H, 85 Kr, or 147 Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process

  7. Voltage regulation in distribution networks with distributed generation

    Science.gov (United States)

    Blažič, B.; Uljanić, B.; Papič, I.

    2012-11-01

    The paper deals with the topic of voltage regulation in distribution networks with relatively high distributed energy resources (DER) penetration. The problem of voltage rise is described and different options for voltage regulation are given. The influence of DER on voltage profile and the effectiveness of the investigated solutions are evaluated by means of simulation in DIgSILENT. The simulated network is an actual distribution network in Slovenia with a relatively high penetration of distributed generation. Recommendations for voltage control in networks with DER penetration are given at the end.

  8. Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants.

    Directory of Open Access Journals (Sweden)

    Wendy B Iser

    2011-03-01

    Full Text Available Insulin/IGF-I-like signaling (IIS has both cell autonomous and non-autonomous functions. In some cases, targets through which IIS regulates cell-autonomous functions, such as cell growth and metabolism, have been identified. In contrast, targets for many non-autonomous IIS functions, such as C. elegans dauer morphogenesis, remain elusive. Here, we report the use of genomic and genetic approaches to identify potential non-autonomous targets of C. elegans IIS. First, we used transcriptional microarrays to identify target genes regulated non-autonomously by IIS in the intestine or in neurons. C. elegans IIS controls expression of a number of stress response genes, which were differentially regulated by tissue-restricted IIS. In particular, expression of sod-3, a MnSOD enzyme, was not regulated by tissue-restricted IIS on the microarrays, while expression of hsp-16 genes was rescued back to wildtype by tissue restricted IIS. One IIS target regulated non-autonomously by age-1 was cyp-35B1/dod-13, encoding a cytochrome P450. Genetic analysis of the cyp-35B1 promoter showed both DAF-16 and HSF-1 are direct regulators. Based on these findings, we propose that hsf-1 may participate in the pathways mediating non-autonomous activities of age-1 in C. elegans.

  9. Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants.

    Science.gov (United States)

    Iser, Wendy B; Wilson, Mark A; Wood, William H; Becker, Kevin; Wolkow, Catherine A

    2011-03-09

    Insulin/IGF-I-like signaling (IIS) has both cell autonomous and non-autonomous functions. In some cases, targets through which IIS regulates cell-autonomous functions, such as cell growth and metabolism, have been identified. In contrast, targets for many non-autonomous IIS functions, such as C. elegans dauer morphogenesis, remain elusive. Here, we report the use of genomic and genetic approaches to identify potential non-autonomous targets of C. elegans IIS. First, we used transcriptional microarrays to identify target genes regulated non-autonomously by IIS in the intestine or in neurons. C. elegans IIS controls expression of a number of stress response genes, which were differentially regulated by tissue-restricted IIS. In particular, expression of sod-3, a MnSOD enzyme, was not regulated by tissue-restricted IIS on the microarrays, while expression of hsp-16 genes was rescued back to wildtype by tissue restricted IIS. One IIS target regulated non-autonomously by age-1 was cyp-35B1/dod-13, encoding a cytochrome P450. Genetic analysis of the cyp-35B1 promoter showed both DAF-16 and HSF-1 are direct regulators. Based on these findings, we propose that hsf-1 may participate in the pathways mediating non-autonomous activities of age-1 in C. elegans.

  10. 48 CFR 245.606-70 - Instructions for completing DD Form 1342, DoD Property Record.

    Science.gov (United States)

    2010-10-01

    ... completing DD Form 1342, DoD Property Record. 245.606-70 Section 245.606-70 Federal Acquisition Regulations... completing DD Form 1342, DoD Property Record. (a) The contractor shall list excess industrial plant equipment (IPE) on DD Form 1342, DoD Property Record, and submit it to the Government property administrator for...

  11. Defense Primer: DOD Contractors

    Science.gov (United States)

    2017-02-10

    functions, from intelligence analysis or software development to landscaping or food service. Why does DOD use individual contractors? Going back to...that provide professional services, from research to management support. The bulk of contractors—more than 70%—provide products, and these include...10 U.S.C. Part IV: Service, Supply, and Procurement. CRS Products CRS In Focus IF10548, Defense Primer: U.S. Defense Industrial Base, by Daniel

  12. Effects of new environmental regulations on coal-fired generation

    International Nuclear Information System (INIS)

    LaCount, R.

    1999-01-01

    As restructuring of the electricity industry places downward pressure on power production costs, new environmental regulations are having the opposite effect. Although power plants may be subject to a variety of environmental regulations over the next ten years including reductions in mercury, toxics, and carbon dioxide, new regulations for sulfur dioxide (SO2) and nitrogen oxides (NOX) are poised to impact the electricity industry in the very short term. The cost for coal-fired power plants to comply with these new regulations has the potential to alter their competitive position. January 1, 2000 marks the beginning of Phase II for the Environmental Protection Agency's SO2 allowance market. Starting in January, all coal and oil plants above 25 MW will be required to comply with the federal SO2 provisions. Regulatory deadlines for NOX are also fast approaching; though the ultimate requirements are still subject to change. On May 1, 1999, a NOX allowance market began for states within the Northeast Ozone Transport Commission (OTC). A second phase of this program is scheduled to begin in 2003 that will lower the overall cap for allowable NOX emissions in the participating states. EPA is also working to expand the reach of regional NOX reductions in 2003 through its NOX SIP call. This program, which is currently subject to litigation, would require NOX reductions in 14 states outside of the OTC. A new study by Resource Data International (RDI), Coal-Fired Generation in Competitive Power Markets, assessed the potential impact that the new SO2 and NOX regulations may have on the competitiveness of coal-fired generation. Overall, the study shows that coal-fired generation will continue to grow despite significant environmental costs and competition from natural gas-fired units. The new environmental regulations have the effect of increasing the dispatch cost of coal-fired units from $0.65/MWh on average in the WSCC to $4.14/MWh on average in the MAAC region. The addition

  13. Integrating distributed generation: Regulation and trends in three leading countries

    International Nuclear Information System (INIS)

    Anaya, Karim L.; Pollitt, Michael G.

    2015-01-01

    This paper explores the trends in the deployment and integration of distributed generation in Germany, Denmark and Sweden. The study concentrates on the regulation of renewable energy generation with a focus on grid access and connection mechanisms. The high rate of distributed generation penetration is mainly based on the early support that these countries gave to the expansion of renewable energy generation – mainly wind and solar – within their respective national policies. Germany and Denmark are the ones with the most sophisticated support schemes, which have shown a dynamic design over time. In terms of connections, Germany has the most favorable connection regime which provides not only priority connection but also priority grid access for generation units that produce electricity from renewable energy sources. Sweden guarantees equal treatment among different technologies (i.e. a non-discrimination principle). High connection costs have been observed specially in Germany and Denmark. The costs of network upgrades are usually socialised across demand customers. However, integration issues should be taken into consideration in order to avoid expansion of distributed generation in a way which unnecessarily raises total system costs, via high connection costs. -- Highlights: •Examination of the DG connection arrangements in Denmark, Germany and Sweden. •Sophisticated subsidy schemes for DG contrast with socialization of connection costs. •No evidence of novel business models for connecting DG units smartly

  14. Inspector General, DOD, Oversight of the Naval Audit Service Audit of the FY 2000 Department of the Navy General Fund Financial Statements

    National Research Council Canada - National Science Library

    2001-01-01

    .... This Bulletin requires the Inspector General, DoD, to express an opinion on the DoD financial statements and to report on the adequacy of internal controls and compliance with laws and regulations...

  15. Energy service contracting in DOD

    International Nuclear Information System (INIS)

    Dahle, D.E.

    1993-01-01

    The U.S. Department of Defense (DOD) annually consumes about $3 Billion in energy to operate facilities at military installations worldwide, representing about 80% of utility operating expense for all Federal facilities. Recent legislation and a Presidential Executive Order have directed DOD by Fiscal Year 2000 to reduce facility energy consumption by 20%, from the level of energy used in Fiscal Year 1985. To achieve this goal it is estimated that energy efficiency improvement investments between $2-3 billion would be required. Considering the competition for resources within DOD as it experiences downsizing and restructuring, DOD will need to seek opportunities to tap alternative investment strategies through energy service contracting to leverage Federal resources. Shared Energy Savings and Operations and Maintenance Energy Services contracting activities in the Department of the Navy will be used to address how such acquisition methods can contribute to achieving DOD energy efficiency goals

  16. Climate regulation enhances the value of second generation biofuel technology

    Science.gov (United States)

    Hertel, T. W.; Steinbuks, J.; Tyner, W.

    2014-12-01

    Commercial scale implementation of second generation (2G) biofuels has long been 'just over the horizon - perhaps a decade away'. However, with recent innovations, and higher oil prices, we appear to be on the verge of finally seeing commercial scale implementations of cellulosic to liquid fuel conversion technologies. Interest in this technology derives from many quarters. Environmentalists see this as a way of reducing our carbon footprint, however, absent a global market for carbon emissions, private firms will not factor this into their investment decisions. Those interested in poverty and nutrition see this as a channel for lessening the biofuels' impact on food prices. But what is 2G technology worth to society? How valuable are prospective improvements in this technology? And how are these valuations affected by future uncertainties, including climate regulation, climate change impacts, and energy prices? This paper addresses all of these questions. We employ FABLE, a dynamic optimization model for the world's land resources which characterizes the optimal long run path for protected natural lands, managed forests, crop and livestock land use, energy extraction and biofuels over the period 2005-2105. By running this model twice for each future state of the world - once with 2G biofuels technology available and once without - we measure the contribution of the technology to global welfare. Given the uncertainty in how these technologies are likely to evolve, we consider a range cost estimates - from optimistic to pessimistic. In addition to technological uncertainty, there is great uncertainty in the conditions characterizing our baseline for the 21st century. For each of the 2G technology scenarios, we therefore also consider a range of outcomes for key drivers of global land use, including: population, income, oil prices, climate change impacts and climate regulation. We find that the social valuation of 2G technologies depends critically on climate change

  17. Regulation of the basement membrane by epithelia generated forces

    Science.gov (United States)

    Tanner, Kandice

    2012-12-01

    Tumor metastasis involves a progressive loss of tissue architecture and dissolution of structural boundaries between the epithelium and connective tissue. The basement membrane (BM), a specialized network of extracellular matrix proteins forms a barrier that physically restricts pre-invasive lesions such that they remain as local insults. The BM is not a static structure, but one that is constantly regenerated and remodeled in the adult organism. Matrix organization also regulates cell function. Thus alterations in the balance of synthesis, remodeling and proteolytic degradation of the extracellular matrix proteins may contribute to a loss of structural integrity. However, the de novo assembly and maintenance of the complex structural properties of in vivo basement membranes remain elusive. Here, this paper highlights the current understanding on the structural properties and the establishment of the BM, and discusses the potential role of self-generated forces in adult tissue remodeling and the maintenance of the BM as a malignancy suppressor.

  18. Regulation of the basement membrane by epithelia generated forces

    International Nuclear Information System (INIS)

    Tanner, Kandice

    2012-01-01

    Tumor metastasis involves a progressive loss of tissue architecture and dissolution of structural boundaries between the epithelium and connective tissue. The basement membrane (BM), a specialized network of extracellular matrix proteins forms a barrier that physically restricts pre-invasive lesions such that they remain as local insults. The BM is not a static structure, but one that is constantly regenerated and remodeled in the adult organism. Matrix organization also regulates cell function. Thus alterations in the balance of synthesis, remodeling and proteolytic degradation of the extracellular matrix proteins may contribute to a loss of structural integrity. However, the de novo assembly and maintenance of the complex structural properties of in vivo basement membranes remain elusive. Here, this paper highlights the current understanding on the structural properties and the establishment of the BM, and discusses the potential role of self-generated forces in adult tissue remodeling and the maintenance of the BM as a malignancy suppressor. (paper)

  19. Next Generation Life Support (NGLS): Variable Oxygen Regulator

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the Variable Oxygen Regulator Element is to develop an oxygen-rated, contaminant-tolerant oxygen regulator to control suit pressure with a...

  20. 32 CFR 286.2 - DoD public information.

    Science.gov (United States)

    2010-07-01

    ..., consistent always with the legitimate public and private interests of the American people. A record requested... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DOD FREEDOM OF INFORMATION ACT PROGRAM REGULATION General Provisions § 286...

  1. Mathematical modelling of steam generator and design of temperature regulator

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanovic, S.S. [EE Institute Nikola Tesla, Belgrade (Yugoslavia)

    1999-07-01

    The paper considers mathematical modelling of once-through power station boiler and numerical algorithm for simulation of the model. Fast and numerically stable algorithm based on the linearisation of model equations and on the simultaneous solving of differential and algebraic equations is proposed. The paper also presents the design of steam temperature regulator by using the method of projective controls. Dynamic behaviour of the system closed with optimal linear quadratic regulator is taken as the reference system. The desired proprieties of the reference system are retained and solutions for superheated steam temperature regulator are determined. (author)

  2. Summary of DOD Acquisition Program Audit Coverage

    National Research Council Canada - National Science Library

    2001-01-01

    This report will provide the DoD audit community with information to support their planning efforts and provide management with information on the extent of audit coverage of DoD acquisition programs...

  3. An Analysis of DOD Fraudulent Vendor Payments

    National Research Council Canada - National Science Library

    Jones-Oxendine, Shawn

    1999-01-01

    ...) known DoD fraudulent vendor cases in light of their management control weaknesses. A high risk of fraudulent vendor payments were present in the DoD, pre-DFAS finance and accounting systems and the current DFAS configuration...

  4. Emotion Generation and Emotion Regulation: One or Two Depends on Your Point of View

    OpenAIRE

    Gross, James J.; Barrett, Lisa Feldman

    2011-01-01

    Emotion regulation has the odd distinction of being a wildly popular construct whose scientific existence is in considerable doubt. In this article, we discuss the confusion about whether emotion generation and emotion regulation can and should be distinguished from one another. We describe a continuum of perspectives on emotion, and highlight how different (often mutually incompatible) perspectives on emotion lead to different views about whether emotion generation and emotion regulation can...

  5. Bottom-up and top-down emotion generation: implications for emotion regulation

    Science.gov (United States)

    Misra, Supriya; Prasad, Aditya K.; Pereira, Sean C.; Gross, James J.

    2012-01-01

    Emotion regulation plays a crucial role in adaptive functioning and mounting evidence suggests that some emotion regulation strategies are often more effective than others. However, little attention has been paid to the different ways emotions can be generated: from the ‘bottom-up’ (in response to inherently emotional perceptual properties of the stimulus) or ‘top-down’ (in response to cognitive evaluations). Based on a process priming principle, we hypothesized that mode of emotion generation would interact with subsequent emotion regulation. Specifically, we predicted that top-down emotions would be more successfully regulated by a top-down regulation strategy than bottom-up emotions. To test this hypothesis, we induced bottom-up and top-down emotions, and asked participants to decrease the negative impact of these emotions using cognitive reappraisal. We observed the predicted interaction between generation and regulation in two measures of emotional responding. As measured by self-reported affect, cognitive reappraisal was more successful on top-down generated emotions than bottom-up generated emotions. Neurally, reappraisal of bottom-up generated emotions resulted in a paradoxical increase of amygdala activity. This interaction between mode of emotion generation and subsequent regulation should be taken into account when comparing of the efficacy of different types of emotion regulation, as well as when reappraisal is used to treat different types of clinical disorders. PMID:21296865

  6. 48 CFR Appendix I to Chapter 2 - Policy and Procedures for the DOD Pilot Mentor-Protege Program

    Science.gov (United States)

    2010-10-01

    ... the DOD Pilot Mentor-Protege Program I Appendix I to Chapter 2 Federal Acquisition Regulations System... and Procedures for the DOD Pilot Mentor-Protege Program I-100Purpose. (a) This Appendix I to 48 CFR Chapter 2 implements the Pilot Mentor-Protégé Program (hereafter referred to as the “Program”) established...

  7. Regulation of distributed generation. A European Policy Paper on the Integration of Distributed Generation in the Internal Electricity Market

    International Nuclear Information System (INIS)

    Van Sambeek, E.J.W.; Scheepers, M.J.J.

    2004-06-01

    In the SUSTELNET project criteria and guidelines have been developed that can create a level playing field in electricity markets between distributed generation (DG) and large scale power generation and will improve the network and market access of DG and electricity supply from renewable energy resources (RES). This report focuses on the European dimensions of DG regulation. The key findings of the SUSTELNET project are compared with the EU legislation, i.e. the current Electricity, Renewables and CHP Directives. Additional EU policy, regulation and initiatives are identified that can help Member States in developing future economically efficient and sustainable electricity supply systems

  8. Navajo Generating Station and Air Visibility Regulations: Alternatives and Impacts

    Energy Technology Data Exchange (ETDEWEB)

    Hurlbut, D. J.; Haase, S.; Brinkman, G.; Funk, K.; Gelman, R.; Lantz, E.; Larney, C.; Peterson, D.; Worley, C.; Liebsch, E.

    2012-01-01

    Pursuant to the Clean Air Act, the U.S. Environmental Protection Agency (EPA) announced in 2009 its intent to issue rules for controlling emissions from Navajo Generating Station that could affect visibility at the Grand Canyon and at several other national parks and wilderness areas. The final rule will conform to what EPA determines is the best available retrofit technology (BART) for the control of haze-causing air pollutants, especially nitrogen oxides. While EPA is ultimately responsible for setting Navajo Generating Station's BART standards in its final rule, it will be the U.S. Department of the Interior's responsibility to manage compliance and the related impacts. This study aims to assist both Interior and EPA by providing an objective assessment of issues relating to the power sector.

  9. Identifying options for regulating the coordination of network investments with investments in distributed electricity generation

    International Nuclear Information System (INIS)

    Nisten, E.

    2010-02-01

    The increase in the distributed generation of electricity, with wind turbines and solar panels, necessitates investments in the distribution network. The current tariff regulation in the Dutch electricity industry, with its ex post evaluation of the efficiency of investments and the frontier shift in the x-factor, delays these investments. In the unbundled electricity industry, the investments in the network need to be coordinated with those in the distributed generation of electricity to enable the DSOs to build enough network capacity. The current Dutch regulations do not provide for a sufficient information exchange between the generators and the system operators to coordinate the investments. This paper analyses these two effects of the Dutch regulation, and suggests improvements to the regulation of the network connection and transportation tariffs to allow for sufficient network capacity and coordination between the investments in the network and in the generation of electricity. These improvements include locally differentiated tariffs that increase with an increasing concentration of distributed generators.

  10. Wind/PV Generation for Frequency Regulation and Oscillation Damping in the Eastern Interconnection

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yong [Univ. of Tennessee, Knoxville, TN (United States); Gracia, Jose R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hadley, Stanton W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Liu, Yilu [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2013-12-01

    This report presents the control of renewable energy sources, including the variable-speed wind generators and solar photovoltaic (PV) generators, for frequency regulation and inter-area oscillation damping in the U.S. Eastern Interconnection (EI). In this report, based on the user-defined wind/PV generator electrical control model and the 16,000-bus Eastern Interconnection dynamic model, the additional controllers for frequency regulation and inter-area oscillation damping are developed and incorporated and the potential contributions of renewable energy sources to the EI system frequency regulation and inter-area oscillation damping are evaluated.

  11. Retinoic acid from the meninges regulates cortical neuron generation.

    Science.gov (United States)

    Siegenthaler, Julie A; Ashique, Amir M; Zarbalis, Konstantinos; Patterson, Katelin P; Hecht, Jonathan H; Kane, Maureen A; Folias, Alexandra E; Choe, Youngshik; May, Scott R; Kume, Tsutomu; Napoli, Joseph L; Peterson, Andrew S; Pleasure, Samuel J

    2009-10-30

    Extrinsic signals controlling generation of neocortical neurons during embryonic life have been difficult to identify. In this study we demonstrate that the dorsal forebrain meninges communicate with the adjacent radial glial endfeet and influence cortical development. We took advantage of Foxc1 mutant mice with defects in forebrain meningeal formation. Foxc1 dosage and loss of meninges correlated with a dramatic reduction in both neuron and intermediate progenitor production and elongation of the neuroepithelium. Several types of experiments demonstrate that retinoic acid (RA) is the key component of this secreted activity. In addition, Rdh10- and Raldh2-expressing cells in the dorsal meninges were either reduced or absent in the Foxc1 mutants, and Rdh10 mutants had a cortical phenotype similar to the Foxc1 null mutants. Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis.

  12. DOD Budget and Transformation: Challenges and Opportunities

    National Research Council Canada - National Science Library

    Walker, David M

    2007-01-01

    ...., military, civilian, contractors) * Get the design and implementation of the NSPS right, including modernizing and integrating the DOD, Service, domain, unit, and individual performance measurement and reward systems...

  13. Metacognitive Unawareness of the Errorful Generation Benefit and Its Effects on Self-Regulated Learning

    Science.gov (United States)

    Yang, Chunliang; Potts, Rosalind; Shanks, David R.

    2017-01-01

    Generating errors followed by corrective feedback enhances retention more effectively than does reading--the benefit of errorful generation--but people tend to be unaware of this benefit. The current research explored this metacognitive unawareness, its effect on self-regulated learning, and how to alleviate or reverse it. People's beliefs about…

  14. 76 FR 11414 - Defense Federal Acquisition Regulation Supplement; Independent Research and Development Technical...

    Science.gov (United States)

    2011-03-02

    ... Acquisition Regulation Supplement; Independent Research and Development Technical Descriptions (DFARS Case... (DFARS) to require contractors to report independent research and development (IR&D) projects generating... to the Defense Technical Information Center (DTIC). Beginning in the 1990s, DoD reduced its technical...

  15. The DoD Method

    International Nuclear Information System (INIS)

    Beyrich, W.; Golly, W.; Peter, N.; Seifert, R.

    1990-05-01

    The DoD method for robust estimating of variances of measurement series (time series) without the exclusion of outliers is described in detail, including its mathematical-statistical basis. In particular, it is proved that the total of all n(n-1)/2 absolute differences obtainable from n measurement values (realizations of random variables) may be subdivided into groups, each of them consisting of stochastically independent differences only. This is necessary for theoretical foundation of the DoDM estimator. Numerical examples of possible applications are given. Thereby, the evaluation of IDA-80 data presented earlier is completed applying the DoDM estimator. (orig.) [de

  16. The temperature control and water quality regulation for steam generator secondary side hydrostatic test

    International Nuclear Information System (INIS)

    Xiao Bo; Liu Dongyong

    2014-01-01

    The secondary side hydrostatic test for the steam generator of M310 unit is to verify the pressure tightness of steam generator secondary side tube sheet and related systems. As for the importance of the steam generator, the water temperature and water quality of hydrostatic test has strict requirements. The discussion on the water temperature control and water quality regulation for the secondary loop hydrostatic test of Fuqing Unit 1 contribute greatly to the guiding work for the preparation of the steam generator pressure test for M310 unit. (authors)

  17. Optimal Operation and Dispatch of Voltage Regulation Devices Considering High Penetrations of Distributed Photovoltaic Generation

    Energy Technology Data Exchange (ETDEWEB)

    Mather, Barry A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hodge, Brian S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Cho, Gyu-Jung [Sungkyunkwan University; Oh, Yun-Sik [Sungkyunkwan University; Kim, Min-Sung [Sungkyunkwan University; Kim, Ji-Soo [Sungkyunkwan University; Kim, Chul-Hwan [Sungkyunkwan University

    2017-06-29

    Voltage regulation devices have been traditionally installed and utilized to support distribution voltages. Installations of distributed energy resources (DERs) in distribution systems are rapidly increasing, and many of these generation resources have variable and uncertain power output. These generators can significantly change the voltage profile for a feeder; therefore, in the distribution system planning stage of the optimal operation and dispatch of voltage regulation devices, possible high penetrations of DERs should be considered. In this paper, we model the IEEE 34-bus test feeder, including all essential equipment. An optimization method is adopted to determine the optimal siting and operation of the voltage regulation devices in the presence of distributed solar power generation. Finally, we verify the optimal configuration of the entire system through the optimization and simulation results.

  18. Regulatory Strategies To Minimize Generation Of Regulated Wastes From Cleanup, Continued Use Or Decommissioning Of Nuclear Facilities Contaminated With Polychlorinated Biphenyls (PCBS) - 11198

    International Nuclear Information System (INIS)

    Lowry, N.

    2010-01-01

    Disposal costs for liquid PCB radioactive waste are among the highest of any category of regulated waste. The high cost is driven by the fact that disposal options are extremely limited. Toxic Substances Control Act (TSCA) regulations require most liquids with PCBs at concentration of (ge) 50 parts-per-million to be disposed by incineration or equivalent destructive treatment. Disposal fees can be as high as $200 per gallon. This figure does not include packaging and the cost to transport the waste to the disposal facility, or the waste generator's labor costs for managing the waste prior to shipment. Minimizing the generation of liquid radioactive PCB waste is therefore a significant waste management challenge. PCB spill cleanups often generate large volumes of waste. That is because the removal of PCBs typically requires the liberal use of industrial solvents followed by a thorough rinsing process. In a nuclear facility, the cleanup process may be complicated by the presence of radiation and other occupational hazards. Building design and construction features, e.g., the presence of open grating or trenches, may also complicate cleanup. In addition to the technical challenges associated with spill cleanup, selection of the appropriate regulatory requirements and approach may be challenging. The TSCA regulations include three different sections relating to the cleanup of PCB contamination or spills. EPA has also promulgated a separate guidance policy for fresh PCB spills that is published as Subpart G of 40 CFR 761 although it is not an actual regulation. Applicability is based on the circumstances of each contamination event or situation. Other laws or regulations may also apply. Identification of the allowable regulatory options is important. Effective communication with stakeholders, particularly regulators, is just as important. Depending on the regulatory path that is taken, cleanup may necessitate the generation of large quantities of regulated waste

  19. Busting DoD Bureaucracy: Creating Fundamental Change by Leveraging Concepts and Practices from the Private Sectors

    National Research Council Canada - National Science Library

    Kreighbaum, Jay

    2002-01-01

    .... Today's DoD bureaucracy continues to generate negative organizational effects such as: parochialism, misplaced loyalties, bureaucracy without an object, multiple layers of no value added staffs (and staff routines...

  20. Provision of Early Intervention and Special Education Services to Eligible DoD Dependents. Final rule.

    Science.gov (United States)

    2015-06-25

    This rule reissues the current regulations and: Establishes policy, assigns responsibilities, and implements the non-funding and non-reporting provisions in DoD for: Provision of early intervention services (EIS) to infants and toddlers with disabilities and their families, as well as special education and related services to children with disabilities entitled under this part to receive education services from the DoD; implementation of a comprehensive, multidisciplinary program of EIS for infants and toddlers with disabilities and their families who, but for age, are eligible to be enrolled in DoD schools; provision of a free appropriate public education (FAPE), including special education and related services, for children with disabilities, as specified in their individualized education programs (IEP), who are eligible to enroll in DoD schools; and monitoring of DoD programs providing EIS, and special education and related services for compliance with this part. This rule also establishes a DoD Coordinating Committee to recommend policies and provide compliance oversight for early intervention and special education.

  1. Policy and network regulation for the integration of distribution generation and renewables for electricity supply

    International Nuclear Information System (INIS)

    Ten Donkelaar, M.; Van Oostvoorn, F.

    2005-08-01

    This study has analysed the existing policy and regulation aimed at the integration of an increased share of Distributed Generation (DG) in electricity supply systems in the European Union. It illustrates the state of the art and progress in the development of support mechanisms and network regulation for large-scale integration of DG. Through a benchmark study a systematic comparison has been made of different DG support schemes and distribution network regulation in EU Member States to a predefined standard, the level playing field. This level playing field has been defined as the situation where energy markets, policy and regulation provide neutral incentives to central versus distributed generation, which results in an economically more efficient electricity supply to the consumer. In current regulation and policy a certain discrepancy can be noticed between the actual regulation and policy support systems in a number of countries, the medium to long term targets and the ideal situation described according to the level playing field objective. Policies towards DG and RES are now mainly aimed at removing short-term barriers, increasing the production share of DG/RES, but often ignoring the more complex barriers of integrating DG/RES that is created by the economic network regulation in current electricity markets

  2. Current regulator for stabilizing electrostatic generators; Regulateur de courant pour stabilisation de generateur electrostatique

    Energy Technology Data Exchange (ETDEWEB)

    Gabet, A; Taieb, J

    1950-07-01

    An instrument consisting of two electronic tubes, a triode and a pentode, connected in series, serves as a stabilizer of the current that charges a working model of a van de Graaff generator. The current is maintained at a level corresponding to an auxiliary variable voltage. The triode maintains that voltage, while the pentode regulates the current. Another application of the circuit, viz., the stabilizing of the generator voltage, will be described elsewhere. (author)

  3. 5 CFR 950.701 - DoD overseas campaign.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false DoD overseas campaign. 950.701 Section... VOLUNTARY ORGANIZATIONS DoD Overseas Campaign § 950.701 DoD overseas campaign. (a) A Combined Federal Campaign is authorized for all Department of Defense (DoD) activities in the overseas areas during a 6-week...

  4. Network Regulation and Support Schemes - How Policy Interactions Affect the Integration of Distributed Generation

    DEFF Research Database (Denmark)

    Ropenus, Stephanie; Jacobsen, Henrik; Schröder, Sascha Thorsten

    2011-01-01

    This article seeks to investigate the interactions between the policy dimensions of support schemes and network regulation and how they affect distributed generation. Firstly, the incentives of distributed generators and distribution system operators are examined. Frequently there exists a trade......-off between the incentives for these two market agents to facilitate the integration of distributed generation. Secondly, the interaction of these policy dimensions is analyzed, including case studies based on five EU Member States. Aspects of operational nature and investments in grid and distributed...

  5. Experience in adjusting of the level regulation system of steam generators of the Rovno NPP

    International Nuclear Information System (INIS)

    Patselyuk, S.N.; Sokolov, A.G.; Kazakov, V.I.; Dorosh, Yu.A.

    1984-01-01

    A system of feed water level control in steam generators at the Rovno NPP with WWER-440 reactors which comprises start-up as well as main regulators is described. The start-up regulator (single-pulsed with a signal by the level) keeps the level in the steam generator at loadings up to 30% of the nominal reactor power Nsub(nom.) The main regulator is connected in the three-pulsed circuit and it receives signals by steam and water flow rate and by the level in the steam generator. The main regulator has been started only at loadings above 40% Nsub(nom.). After reconstruction it was used in the 15-100% Nsub(nom.) range. Characteristics of the level control system in the steam generator at perturbations intoduced by the main circulating pump (MCP) and turbine disconnection as well as change in feed water flow rate have been studied. The studies have revealed that the system ensures necessary quality of control in stationary modes. The system operates stably at perturbations of feed water flow rate up to 50% Nsub(nom.). Perturbations by MCP connections and disconnections is most difficult for control system

  6. Biomass power generation in competitive markets - The impact of instruments and regulations

    International Nuclear Information System (INIS)

    Ackermann, Thomas; Soeder, Lennart

    1999-01-01

    This paper presents and briefly evaluates the most important existing market instruments and market schemes which support the development of renewable energy generation as well as the impact of market regulations on the development of biomass power generation. The evaluation of the existing instruments focuses on the incentives provided by the various instruments to reduce production costs. The instruments and schemes are: Feed-in Tariffs, Net Metering, Bidding Process, Fixed Quotas, Green Certificate Trading, Green Power Exchange, Green Pricing. Feed-in tariffs and net metering are important instruments to get the different technologies 'off the ground', however, they can only be considered an interim solution as they do not necessarily lead to cost reduction. A bidding process is one way to achieve these cost reductions, but high transaction costs will support the development of large renewable energy projects, which is not always the desired effect. Fixed quotas combined with green certificate trading or a power exchange in combination with Green Pricing seem to lead to similar costs reduction, however, so far there is only limited experience with such instruments. The analysis of the impact of market regulations focuses on international electricity markets with a power exchange. Such markets exist, for example, in Scandinavia, England and Wales, Australia, New Zealand and California. The analysis showed that new distributed generation, for example based on biomass, faces significant market barriers. Furthermore, distributed generation is not treated equally within the market regulations compared to large-scale power generation

  7. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling.

    Science.gov (United States)

    Sabharwal, Priyanka; Lee, Changhee; Park, Sungjin; Rao, Meenakshi; Sockanathan, Shanthini

    2011-09-22

    The specification of spinal interneuron and motor neuron identities initiates within progenitor cells, while motor neuron subtype diversification is regulated by hierarchical transcriptional programs implemented postmitotically. Here we find that mice lacking GDE2, a six-transmembrane protein that triggers motor neuron generation, exhibit selective losses of distinct motor neuron subtypes, specifically in defined subsets of limb-innervating motor pools that correlate with the loss of force-generating alpha motor neurons. Mechanistically, GDE2 is expressed by postmitotic motor neurons but utilizes extracellular glycerophosphodiester phosphodiesterase activity to induce motor neuron generation by inhibiting Notch signaling in neighboring motor neuron progenitors. Thus, neuronal GDE2 controls motor neuron subtype diversity through a non-cell-autonomous feedback mechanism that directly regulates progenitor cell differentiation, implying that subtype specification initiates within motor neuron progenitor populations prior to their differentiation into postmitotic motor neurons. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. An improved direct feedback linearization technique for transient stability enhancement and voltage regulation of power generators

    Energy Technology Data Exchange (ETDEWEB)

    Kenne, Godpromesse [Laboratoire d' Automatique et d' Informatique Appliquee (LAIA), Departement de Genie Electrique, Universite de Dschang, B.P. 134 Bandjoun, Cameroun; Goma, Raphael; Lamnabhi-Lagarrigue, Francoise [Laboratoire des Signaux et Systemes (L2S), CNRS-SUPELEC, Universite Paris XI, 3 Rue Joliot Curie, 91192 Gif-sur-Yvette (France); Nkwawo, Homere [Departement GEII, Universite Paris XIII, IUT Villetaneuse, 99 Avenue Jean Baptiste Clement, 93430 Villetaneuse (France); Arzande, Amir; Vannier, Jean Claude [Departement Energie, Ecole Superieure d' Electricite-SUPELEC, 3 Rue Joliot Curie, 91192 Gif-sur-Yvette (France)

    2010-09-15

    In this paper, a simple improved direct feedback linearization design method for transient stability and voltage regulation of power systems is discussed. Starting with the classical direct feedback linearization technique currently applied to power systems, an adaptive nonlinear excitation control of synchronous generators is proposed, which is new and effective for engineering. The power angle and mechanical power input are not assumed to be available. The proposed method is based on a standard third-order model of a synchronous generator which requires only information about the physical available measurements of angular speed, active electric power and generator terminal voltage. Experimental results of a practical power system show that fast response, robustness, damping, steady-state and transient stability as well as voltage regulation are all achieved satisfactorily. (author)

  9. Resolution 8.069/12. It approve the regulations for the large size structures installation, destined for wind power generation

    International Nuclear Information System (INIS)

    2012-01-01

    This resolution approve the regulations for the large size structures installation, destined to wind power generation. The objective of this rule is to regulate the urban conditions of the facilities and the environmental guarantees, safety and inhabitants wholesomeness

  10. The 2000 DOD Financial Management Improvement Plan

    National Research Council Canada - National Science Library

    2001-01-01

    .... As a result, DoD has prepared the Financial Management Improvement Plan (the Plan), which is a strategic framework that includes the Departments financial management concept of operations for the future...

  11. Valuing the DoD Process Output

    National Research Council Canada - National Science Library

    Bourazanis, Petros; Gusnadi

    2005-01-01

    .... As a public institution that provides a public good to the people, the DoD has difficulties in using the prominent investment financial ratios used by the private sector as a metric of their performance...

  12. DoD International Armaments Cooperation Policy

    National Research Council Canada - National Science Library

    Cohen, William

    1997-01-01

    .... In the evolving environment of coalition warfare, limited resources, and a global industrial and technology base, it is DoD policy that we utilize International Armaments Cooperation to the maximum...

  13. The 2000 DOD Financial Management Improvement Plan

    National Research Council Canada - National Science Library

    2001-01-01

    The Federal Financial Management Improvement Act of 1996 requires DoD financial management systems to comply substantially with Federal financial management system requirements, Federal accounting standards, and the U.S...

  14. Increasing penetration of renewable and distributed electricity generation and the need for different network regulation

    International Nuclear Information System (INIS)

    Joode, J. de; Jansen, J.C.; Welle, A.J. van der; Scheepers, M.J.J.

    2009-01-01

    The amount of decentralised electricity generation (DG) connected to distribution networks increases across EU member states. This increasing penetration of DG units poses potential costs and benefits for distribution system operators (DSOs). These DSOs are regulated since the business of electricity distribution is considered to be a natural monopoly. This paper identifies the impact of increasing DG penetration on the DSO business under varying parameters (network characteristics, DG technologies, network management type) and argues that current distribution network regulation needs to be improved in order for DSOs to continue to facilitate the integration of DG in the network. Several possible adaptations are analysed.

  15. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation.

    LENUS (Irish Health Repository)

    Ni Ainle, Fionnuala

    2009-08-20

    Protamine sulfate is a positively charged polypeptide widely used to reverse heparin-induced anticoagulation. Paradoxically, prospective randomized trials have shown that protamine administration for heparin neutralization is associated with increased bleeding, particularly after cardiothoracic surgery with cardiopulmonary bypass. The molecular mechanism(s) through which protamine mediates this anticoagulant effect has not been defined. In vivo administration of pharmacologic doses of protamine to BALB\\/c mice significantly reduced plasma thrombin generation and prolonged tail-bleeding time (from 120 to 199 seconds). Similarly, in pooled normal human plasma, protamine caused significant dose-dependent prolongations of both prothrombin time and activated partial thromboplastin time. Protamine also markedly attenuated tissue factor-initiated thrombin generation in human plasma, causing a significant decrease in endogenous thrombin potential (41% +\\/- 7%). As expected, low-dose protamine effectively reversed the anticoagulant activity of unfractionated heparin in plasma. However, elevated protamine concentrations were associated with progressive dose-dependent reduction in thrombin generation. To assess the mechanism by which protamine mediates down-regulation of thrombin generation, the effect of protamine on factor V activation was assessed. Protamine was found to significantly reduce the rate of factor V activation by both thrombin and factor Xa. Protamine mediates its anticoagulant activity in plasma by down-regulation of thrombin generation via a novel mechanism, specifically inhibition of factor V activation.

  16. Regulation of the water level in the steam generator using modal control

    International Nuclear Information System (INIS)

    Benoit, Guy.

    1981-11-01

    The nuclear power reactors type P.W.R. (900 MWe) have three steam generators (S.G.). The problem of the water level in the S.G. is analogous to that for a system with non-minimum phase. This causes a serious trouble for the stability of the regulation, which is actually realized by using the PID regulator. The first part of this study is devoted to construct a mathematical model which represents the S.G. This model is simulated on a digital computer, which order is six. The validity of this model is checked using actual measured signals which have been collected from the BUGEY III power reactor. In the second part, the mathematical representation for simulating the regulation of the level in the S.G. using the modal control is given. The simulation of the actual system is given in the third part. This actual system is composed from the S.G. as well as the PI and PID for regulating the water level. As results from this study, it can be concluded that, the modal control improves the regulation of the water level. The accuracy of the steam flow measurement at low rate is poor. So, the actual regulating system using the measurements has a reduced performance performance. The control modal which is represented in this study overcome this problem [fr

  17. Striking a balance: does nitrate uptake and metabolism regulate both NO generation and scavenging?

    DEFF Research Database (Denmark)

    Mur, Luis A J; Hebelstrup, Kim; Gupta, Kapuganti J

    2013-01-01

    Nitric oxide (NO) influences many aspects of plant development and responses to stress.The concentration of NO can play an important role in influencing its action (for example, in stomatal regulation; Wilson et al., 2009) so that the mechanisms through which NO content is modulated must...... be an important facet of NO research. Whilst NO generation mechanisms are clearly important, NO removal is of equal relevance, especially as plants will be continually exposed to NOx (NO + NO2) gases derived from soil microbial activity (Mur et al., 2013). Establishing and regulating a poise between NO generation......, NO fumigation from external sources and NO scavenging, which also needs to be flexible enough to change in response to a variety of physiological cues, is an under-considered aspect of plant NO biology...

  18. Next-Generation Performance-Based Regulation: Emphasizing Utility Performance to Unleash Power Sector Innovation

    Energy Technology Data Exchange (ETDEWEB)

    Logan, Jeffrey S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Zinaman, Owen R [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Littell, David [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Kadoch, Camille [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Baker, Phil [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Bharvirkar, Ranjit [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Dupuy, Max [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Hausauer, Brenda [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Linvill, Carl [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Migden-Ostrander, Janine [Regulatory Assistance Project (RAP), Montpelier, VT (United States); Rosenow, Jan [Regulatory Assistance Project; Xuan, Wang [Regulatory Assistance Project

    2017-09-12

    Performance-based regulation (PBR) enables regulators to reform hundred-year-old regulatory structures to unleash innovations within 21st century power systems. An old regulatory paradigm built to ensure safe and reliable electricity at reasonable prices from capital-intensive electricity monopolies is now adjusting to a new century of disruptive technological advances that change the way utilities make money and what value customers expect from their own electricity company. Advanced technologies are driving change in power sectors around the globe. Innovative technologies are transforming the way electricity is generated, delivered, and consumed. These emerging technology drivers include renewable generation, distributed energy resources such as distributed generation and energy storage, demand-side management measures such as demand-response, electric vehicles, and smart grid technologies and energy efficiency (EE). PBR enables regulators to recognize the value that electric utilities bring to customers by enabling these advanced technologies and integrating smart solutions into the utility grid and utility operations. These changes in the electric energy system and customer capacities means that there is an increasing interest in motivating regulated entities in other areas beyond traditional cost-of-service performance regulation. This report addresses best practices gleaned from more than two decades of PBR in practice, and analyzes how those best practices and lessons can be used to design innovative PBR programs. Readers looking for an introduction to PBR may want to focus on Chapters 1-5. Chapters 6 and 7 contain more detail for those interested in the intricate workings of PBR or particularly innovative PBR.

  19. A device for regulating the field generated by a superconducting winding or the gradient of same

    International Nuclear Information System (INIS)

    Duret, Denis; Dunand, J.-J.

    1974-01-01

    Description is given of a stabilizing device which does not require the use of a specific solvent. Changes occurring in the field generated by the main winding and the correcting winding are transmitted by a superconducting unit to a quantum superconducting interferometer. An impedance measurement provides an error-signal, the latter being integrated for feeding the correcting winding. A form of embodiment relates to the regulation of a modulated field. This can be applied to nuclear magnetic resonance spectrometers [fr

  20. 77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation...

    Science.gov (United States)

    2012-02-24

    ...DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement to extend the program period for the DoD Test Program for Negotiation of Comprehensive Small Business Subcontracting Plans.

  1. 48 CFR 252.219-7003 - Small business subcontracting plan (DoD contracts).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Small business... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.219-7003 Small business subcontracting plan (DoD contracts). As prescribed in 219.708(b)(1)(A), use the following clause: Small Business...

  2. 48 CFR 245.7206 - Transmitting DD Form 1342, DoD Property Record.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Transmitting DD Form 1342... Instructions 245.7206 Transmitting DD Form 1342, DoD Property Record. As a minimum, the plant clearance officer will provide the following information in a letter forwarding DD Forms 1342 to DSCR— (a) Number of DD...

  3. Self-Tuning Linear Quadratic Supervisory Regulation of a Diesel Generator using Large-Signal State Estimation

    DEFF Research Database (Denmark)

    Knudsen, Jesper Viese; Bendtsen, Jan Dimon; Andersen, Palle

    2016-01-01

    In this paper, a self-tuning linear quadratic supervisory regulator using a large-signal state estimator for a diesel driven generator set is proposed. The regulator improves operational efficiency, in comparison to current implementations, by (i) automating the initial tuning process and (ii...... throughout the operating range of the diesel generator....

  4. ‘Standard’ incentive regulation hinders the integration of renewable energy generation

    International Nuclear Information System (INIS)

    Nykamp, Stefan; Andor, Mark; Hurink, Johann L.

    2012-01-01

    The connection and distribution of growing, decentralized electricity generation from renewable energy sources (RES-E) is leading to massive investment needs. Besides investing in additional ‘conventional’ assets (e.g. cables), grid operators can also invest in innovative ‘smart solutions’ like local storage capacities or voltage regulation appliances, which may be a more suitable way of integrating RES-E. This paper investigates the influence of incentive regulation on the investment decision of grid operators to integrate RES-E. We describe the technical and regulatory background, explain the advantages of ‘smart solutions’ and present an approach for comparing investment scenarios. As an example, we calculate the profitability of investments in a case study of the German electricity market. We apply Data Envelopment Analysis (DEA) and Stochastic Frontier Analysis (SFA) to show the influence of the investment alternatives on grid operator efficiency objectives. We demonstrate that under current ‘standard’ incentive regulation, the grid operators gain profitability by avoiding investments and – if they are forced to invest – by not implementing ‘smart solutions’. The results highlight the need to consider innovation in the regulation design. Further research should investigate specific instruments that can be used to account for innovation. Our brief discussion of such instruments provides a starting point. - Highlights: ► We measure the influence of investments on efficiency by applying DEA and SFA. ► We compare the profitability of alternative investments under incentive regulation. ► Incentive regulation gives incentives to refuse investment at all. ► If DSOs are forced to invest, reinforcement is preferable to smart solutions. ► Ways to consider innovation in incentive regulations are required and discussed.

  5. Functional overlap of top-down emotion regulation and generation: an fMRI study identifying common neural substrates between cognitive reappraisal and cognitively generated emotions.

    Science.gov (United States)

    Otto, Benjamin; Misra, Supriya; Prasad, Aditya; McRae, Kateri

    2014-09-01

    One factor that influences the success of emotion regulation is the manner in which the regulated emotion was generated. Recent research has suggested that reappraisal, a top-down emotion regulation strategy, is more effective in decreasing self-reported negative affect when emotions were generated from the top-down, versus the bottom-up. On the basis of a process overlap framework, we hypothesized that the neural regions active during reappraisal would overlap more with emotions that were generated from the top-down, rather than from the bottom-up. In addition, we hypothesized that increased neural overlap between reappraisal and the history effects of top-down emotion generation would be associated with increased reappraisal success. The results of several analyses suggested that reappraisal and emotions that were generated from the top-down share a core network of prefrontal, temporal, and cingulate regions. This overlap is specific; no such overlap was observed between reappraisal and emotions that were generated in a bottom-up fashion. This network consists of regions previously implicated in linguistic processing, cognitive control, and self-relevant appraisals, which are processes thought to be crucial to both reappraisal and top-down emotion generation. Furthermore, individuals with high reappraisal success demonstrated greater neural overlap between reappraisal and the history of top-down emotion generation than did those with low reappraisal success. The overlap of these key regions, reflecting overlapping processes, provides an initial insight into the mechanism by which generation history may facilitate emotion regulation.

  6. Voltage regulation in MV networks with dispersed generations by a neural-based multiobjective methodology

    Energy Technology Data Exchange (ETDEWEB)

    Galdi, Vincenzo [Dipartimento di Ingegneria dell' Informazione e Ingegneria Elettrica, Universita degli studi di Salerno, Via Ponte Don Melillo 1, 84084 Fisciano (Italy); Vaccaro, Alfredo; Villacci, Domenico [Dipartimento di Ingegneria, Universita degli Studi del Sannio, Piazza Roma 21, 82100 Benevento (Italy)

    2008-05-15

    This paper puts forward the role of learning techniques in addressing the problem of an efficient and optimal centralized voltage control in distribution networks equipped with dispersed generation systems (DGSs). The proposed methodology employs a radial basis function network (RBFN) to identify the multidimensional nonlinear mapping between a vector of observable variables describing the network operating point and the optimal set points of the voltage regulating devices. The RBFN is trained by numerical data generated by solving the voltage regulation problem for a set of network operating points by a rigorous multiobjective solution methodology. The RBFN performance is continuously monitored by a supervisor process that notifies when there is the need of a more accurate solution of the voltage regulation problem if nonoptimal network operating conditions (ex post monitoring) or excessive distances between the actual network state and the neuron's centres (ex ante monitoring) are detected. A more rigorous problem solution, if required, can be obtained by solving the voltage regulation problem by a conventional multiobjective optimization technique. This new solution, in conjunction with the corresponding input vector, is then adopted as a new train data sample to adapt the RBFN. This online training process allows RBFN to (i) adaptively learn the more representative domain space regions of the input/output mapping without needing a prior knowledge of a complete and representative training set, and (ii) manage effectively any time varying phenomena affecting this mapping. The results obtained by simulating the regulation policy in the case of a medium-voltage network are very promising. (author)

  7. GABA regulates synaptic integration of newly generated neurons in the adult brain

    Science.gov (United States)

    Ge, Shaoyu; Goh, Eyleen L. K.; Sailor, Kurt A.; Kitabatake, Yasuji; Ming, Guo-Li; Song, Hongjun

    2006-02-01

    Adult neurogenesis, the birth and integration of new neurons from adult neural stem cells, is a striking form of structural plasticity and highlights the regenerative capacity of the adult mammalian brain. Accumulating evidence suggests that neuronal activity regulates adult neurogenesis and that new neurons contribute to specific brain functions. The mechanism that regulates the integration of newly generated neurons into the pre-existing functional circuitry in the adult brain is unknown. Here we show that newborn granule cells in the dentate gyrus of the adult hippocampus are tonically activated by ambient GABA (γ-aminobutyric acid) before being sequentially innervated by GABA- and glutamate-mediated synaptic inputs. GABA, the major inhibitory neurotransmitter in the adult brain, initially exerts an excitatory action on newborn neurons owing to their high cytoplasmic chloride ion content. Conversion of GABA-induced depolarization (excitation) into hyperpolarization (inhibition) in newborn neurons leads to marked defects in their synapse formation and dendritic development in vivo. Our study identifies an essential role for GABA in the synaptic integration of newly generated neurons in the adult brain, and suggests an unexpected mechanism for activity-dependent regulation of adult neurogenesis, in which newborn neurons may sense neuronal network activity through tonic and phasic GABA activation.

  8. Voltage Regulation Using a Permanent Magnet Synchronous Generator with a Series Compensator: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Ping; Wu, Ziping; Muljadi, Eduard; Gao, Wenzhong

    2015-08-24

    A wind power plant (WPP) is often operated at unity power factor, and the utility host where the WPP connects prefers to regulate the voltage. Although this may not be an issue in a stiff grid, the connection to a weak grid can be a problematic. This paper explores the advantages of having voltage regulation capability via reactive power control. Another issue in wind power generation is that not all turbines are able to control their reactive power due to technical reasons or contractual obligations. A synchronous condenser (SC) using a permanent magnet synchronous generator (PMSG) is proposed to provide necessary reactive power for regulating voltage at a weak grid connection. A PMSG has the advantage of higher efficiency and reliability. Because of its lack of a field winding, a PMSG is typically controlled by a full-power converter, which can be costly. In the proposed system, the reactive power of the SC is controlled by a serially connected compensator operating in a closed-loop configuration. The compensator also damps the PMSG’s tendency to oscillate. The compensator’s VA rating is only a fraction of the rating of the SC and the PMSG. In this initial investigation, the proposed scheme is shown to be effective by computer simulations.

  9. How is the DoD Logistics Transformation Going?

    National Research Council Canada - National Science Library

    Eden, Rick

    2001-01-01

    ...: Cost Reduction--The DoD logistics system must reduce the costs of providing support. Responsiveness--The DoD logistics system must improve its basic business processes to match best commercial performance levels...

  10. Interagency cooperation : FEMA and DOD in domestic support operations.

    Science.gov (United States)

    1997-05-01

    This paper studies the interagency cooperation between DOD and FEMA, focusing specifically on the evolution of doctrine and procedures for responding to natural disasters. While both FEMA and DOD have improved in their ability to respond to disasters...

  11. Increasing the Adaptability of DoD Forces and Organizations

    National Research Council Canada - National Science Library

    Gorman, David

    2001-01-01

    The post-Cold War world demands increased adaptability. Since the accelerating pace of technological change reduces DoD ability to forecast threat characteristics, DOD force planning methodology is undermined...

  12. 48 CFR 245.7101-3 - DD Form 1348-1, DoD Single Line Item Release/Receipt Document.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1348-1, DoD Single Line Item Release/Receipt Document. 245.7101-3 Section 245.7101-3 Federal Acquisition Regulations... PROPERTY Plant Clearance Forms 245.7101-3 DD Form 1348-1, DoD Single Line Item Release/Receipt Document...

  13. Report of the DOD-DOE Workshop on Converting Waste to Energy Using Fuel Cells

    Science.gov (United States)

    2011-10-01

    cell research, development, and demonstration. Along with the general program overview, Dr. Satyapal highlighted the vast amount of biogas resources...Page ii DOD-DOE Workshop Summary on Converting Waste to Energy Using Fuel Cells List of Tables Table 1. Comparison by Generator Type: Based on 40...Table 2. Typical Composition of Biogas from Various Waste Streams ....................................................... 8 Table D-1

  14. PEDOT pillar fabrication using DOD inkjet system

    Science.gov (United States)

    Cui, Wei; Chang, Cheng-Ling; Wang, Wei-Chih

    2012-04-01

    In this paper, we present our preliminary results of high aspect ratio 3D PEDOT pillar study by drop-on demand (DOD) direct printing system. Design of the experimental setup and the fabrication of the DOD PEDOT pillar are introduced. Currently, the system can achieve a PEDOT pillar with a height of 300 μm and 80 μm in diameter. The proposed PEDOT 3D printing process has a wide range of potential applications in the eletronics and display industry.

  15. Design of the robust synchronous generator stator voltage regulator based on the interval plant model

    Directory of Open Access Journals (Sweden)

    Stojić Đorđe

    2013-01-01

    Full Text Available In this paper a novel method for the stator voltage regulator of a synchronous generator based on the interval plant mode, is presented. Namely, it is shown in the literature that, in order to design a controller for the first-order compensator, the limited number of interval plants needs to be examined. Consequently, the intervals of the plant model parameter variations used to calculate the four extreme interval plants required for the sequential PI controller design are determined. The controller is designed using frequency-domain-based techniques, while its robust performance is examined using simulation tests.

  16. Regulation for delivery of subsidies for urgent safety measures for atomic power generating facilities

    International Nuclear Information System (INIS)

    1984-01-01

    The regulations provide for subsidies for the emergency measures taken by the prefecture concerned in preparation for a major accident in a nuclear power generating, etc. facility. These activities include an emergency communication network, emergency medical care, personnel education, and outfitting of emergency personnel. The contents are as follows: terms of subsidy allocations, the sum of a subsidy allocation, applications for subsidies, determination of subsidy allocations, withdrawal of applications the conditions attached to the allocations, a report on the work proceedings, a report on the results, confirmation on the sum of the subsidies, withdrawal of the decision for subsidies, limitations for the disposal of the properties, etc. (Mori, K.)

  17. Graphene-Based Functional Architectures: Sheets Regulation and Macrostructure Construction toward Actuators and Power Generators.

    Science.gov (United States)

    Cheng, Huhu; Huang, Yaxin; Shi, Gaoquan; Jiang, Lan; Qu, Liangti

    2017-07-18

    regulated graphene sheets and well-constructed assemblies present promising applications in energy-conversion materials and device systems focusing on actuators that can convert different energy forms (e.g., electric, chemical, photonic, thermal, etc.) to mechanical actuation and electrical generators that can directly transform environmental energy to electric power. These results reveal that graphene sheets with surface chemistry and microstructure regulations as well as their rationally designed assemblies provide a promising and abundant platform for development of diverse functional devices. We hope that this Account will promote further efforts toward fundamental research on graphene regulation and the wide applications of advanced designed assemblies in new types of energy-conversion materials/devices and beyond.

  18. Coordinated control of wind generation and energy storage for power system frequency regulation

    Science.gov (United States)

    Baone, Chaitanya Ashok

    Large-scale centralized synchronous generators have long been the primary actors in exercising active power and frequency control, and much of the existing grid control framework is predicated upon their dynamic terminal characteristics. Important among these characteristics is the inertia of such generators. These play key roles in determining the electromechanical stability of the electric power grid. Modern wind generator systems are partially or fully connected to the grid through power electronic interfaces, and hence do not present the same level of inertial coupling. The absence of inertial frequency response from modern wind generator systems is a topic of growing concern in power engineering practice, as the penetration of wind generation is expected to grow dramatically in the next few years. Solutions proposed in the literature have sought to address this problem by seeking to mimic the inherent inertial response characteristics of traditional synchronous generators via control loops added to wind generators. Recent literature has raised concerns regarding this approach, and the work here will further examine its shortcomings, motivating approaches that seek to optimally design for the characteristics of the equipment exercising the control, rather than forcing new technologies to mimic the characteristics of synchronous machines. In particular, this work will develop a new approach to power system frequency regulation, with features suited to distributed energy storage devices such as grid-scale batteries and wind turbine speed and blade pitch control. The dynamic characteristics of these new technologies are treated along with existing mechanisms, such as synchronous machine governor control, to develop a comprehensive multi-input control design approach. To make the method practically feasible for geographically distributed power systems, an observer-based distributed control design utilizing phasor measurement unit (PMU) signals along with local

  19. Emergency Supplemental Appropriations for DoD Needs Arising from Hurricane Katrina at Selected DoD Components

    National Research Council Canada - National Science Library

    Granetto, Paul J; Marsh, Patricia A; Pfeil, Lorin T; Adu, Henry Y; Appiah, Emmanuel A; Lawrence, Charlisa D; Loftin, Sharon A; Straw, Richard W; Davis, Sonya T; Hart, Erin S

    2007-01-01

    .... The Inspector General (IG), DoD, performed this audit to determine if the emergency supplemental appropriations for DoD needs arising from Hurricane Katrina and others were used for their intended purposes...

  20. 76 FR 50714 - Federal Acquisition Regulation; Documenting Contractor Performance; Correction

    Science.gov (United States)

    2011-08-16

    ... Regulation; Documenting Contractor Performance; Correction AGENCY: Department of Defense (DoD), General... August 9, 2011, regarding the proposed rule for Documenting Contractor Performance. DATES: The comment...

  1. Next-generation sequencing analysis of gene regulation in the rat model of retinopathy of prematurity.

    Science.gov (United States)

    Griffith, Rachel M; Li, Hu; Zhang, Nan; Favazza, Tara L; Fulton, Anne B; Hansen, Ronald M; Akula, James D

    2013-08-01

    The purpose of this study was to identify the genes, biochemical signaling pathways, and biological themes involved in the pathogenesis of retinopathy of prematurity (ROP). Next-generation sequencing (NGS) was performed on the RNA transcriptome of rats with the Penn et al. (Pediatr Res 36:724-731, 1994) oxygen-induced retinopathy model of ROP at the height of vascular abnormality, postnatal day (P) 19, and normalized to age-matched, room-air-reared littermate controls. Eight custom-developed pathways with potential relevance to known ROP sequelae were evaluated for significant regulation in ROP: The three major Wnt signaling pathways, canonical, planar cell polarity (PCP), and Wnt/Ca(2+); two signaling pathways mediated by the Rho GTPases RhoA and Cdc42, which are, respectively, thought to intersect with canonical and non-canonical Wnt signaling; nitric oxide signaling pathways mediated by two nitric oxide synthase (NOS) enzymes, neuronal (nNOS) and endothelial (eNOS); and the retinoic acid (RA) signaling pathway. Regulation of other biological pathways and themes was detected by gene ontology using the Kyoto Encyclopedia of Genes and Genomes and the NIH's Database for Annotation, Visualization, and Integrated Discovery's GO terms databases. Canonical Wnt signaling was found to be regulated, but the non-canonical PCP and Wnt/Ca(2+) pathways were not. Nitric oxide signaling, as measured by the activation of nNOS and eNOS, was also regulated, as was RA signaling. Biological themes related to protein translation (ribosomes), neural signaling, inflammation and immunity, cell cycle, and cell death were (among others) highly regulated in ROP rats. These several genes and pathways identified by NGS might provide novel targets for intervention in ROP.

  2. Next Generation Sequencing Analysis of Gene Regulation in the Rat Model of Retinopathy of Prematurity

    Science.gov (United States)

    Griffith, Rachel M.; Li, Hu; Zhang, Nan; Favazza, Tara L.; Fulton, Anne B.; Hansen, Ronald M.; Akula, James D.

    2013-01-01

    Purpose To identify the genes, biochemical signaling pathways and biological themes involved in the pathogenesis of retinopathy of prematurity (ROP). Methods Next-generation sequencing (NGS) was performed on the RNA transcriptome of rats with the Penn et al. (1994) oxygen-induced retinopathy (OIR) model of ROP at the height of vascular abnormality, postnatal day (P) 19, and normalized to age-matched, room-air-reared littermate controls. Eight custom developed pathways with potential relevance to known ROP sequelae were evaluated for significant regulation in ROP: The three major Wnt signaling pathways, canonical, planar cell polarity (PCP), and Wnt/Ca2+, two signaling pathways mediated by the Rho GTPases RhoA and Cdc42, which are respectively thought to intersect with canonical and noncanonical Wnt signaling, nitric oxide signaling pathways mediated by two nitrox oxide synthase (NOS) enzymes, neuronal (nNOS) and endothelial (eNOS), and the retinoic acid (RA) signaling pathway. Regulation of other biological pathways and themes were detected by gene ontology using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the NIH's Database for Annotation, Visualization and Integrated Discovery (DAVID)'s GO terms databases. Results Canonical Wnt signaling was found to be regulated, but the non-canonical PCP and Wnt/Ca2+ pathways were not. Nitric oxide (NO) signaling, as measured by the activation of nNOS eNOS, was also regulated, as was RA signaling. Biological themes related to protein translation (ribosomes), neural signaling, inflammation and immunity, cell cycle and cell death, were (among others) highly regulated in ROP rats. Conclusions These several genes and pathways identified by NGS might provide novel targets for intervention in ROP. PMID:23775346

  3. Department of Defense Financial Management Regulation. Volume 3. Budget Execution-Availability and Use of Budgetary Resources

    National Research Council Canada - National Science Library

    1996-01-01

    .... In addition, it directs statutory and regulatory financial reporting requirements. Volume 3 of the "DoD Financial Management Regulation" establishes procedures for DoD Components to use in budget execution...

  4. Obestatin enhances in vitro generation of pancreatic islets through regulation of developmental pathways.

    Directory of Open Access Journals (Sweden)

    Alessandra Baragli

    Full Text Available Availability of large amounts of in vitro generated β-cells may support replacement therapy in diabetes. However, methods to obtain β-cells from stem/progenitor cells are limited by inefficient endocrine differentiation. We have recently shown that the ghrelin gene product obestatin displays beneficial effects on pancreatic β-cell survival and function. Obestatin prevents β-cell apoptosis, preserves β-cell mass and stimulates insulin secretion in vitro and in vivo, in both normal and diabetic conditions. In the present study, we investigated whether obestatin may promote in vitro β-cell generation from mouse pancreatic islet-derived precursor cells. Treatment of cultured islets of Langerhans with obestatin (i enriched cells expressing the mesenchymal/neuronal marker nestin, which is associated with pancreatic precursors; (ii increased cell survival and reduced apoptosis during precursor selection; (iii promoted the generation of islet-like cell clusters (ICCs with increased insulin gene expression and C-peptide secretion. Furthermore, obestatin modulated the expression of fibroblast growth factor receptors (FGFRs, Notch receptors and neurogenin 3 (Ngn3 during islet-derived precursor cell selection and endocrine differentiation. These results indicate that obestatin improves the generation of functional β-cells/ICCs in vitro, suggesting implications for cell-based replacement therapy in diabetes. Moreover, obestatin may play a role in regulating pathways involved in pancreas development and regeneration.

  5. UNLICENSED RENEWABLE ENERGY GENERATION: A REVIEW OF REGULATION AND APPLICATIONS IN THE CONTEXT OF TURKEY

    Directory of Open Access Journals (Sweden)

    Mustafa GOZEN

    2015-01-01

    Full Text Available Turkey has stipulated that renewable energy sources (RES will have at least 30% share in electricity generation by 2023. To reach this target, a renewable energy promotion law (Law No. 5346 was enacted in 2005 and later amended in 2011. Through Law No. 5346, Turkey has launched a feed-in tariff (FIT for RES-based electricity with additional premium for the use of local equipment. The FIT is guaranteed for 10 years from the date of operation and valid only for RES power plants commissioned between the 18th May, 2005 and the 31th of December 2020. In addition, RES power plants with a capacity of up to 1 MW are exempted from licensing and establishing legal entities. There is an increasing demand to install unlicensed RES generators, mostly solar power plants, all over the country. At least one consumption unit must be associated with an unlicensed power plant. Excess generation from unlicensed RES power plants is automatically priced at the FIT for 10 years. Except for the FIT mechanism, unlicensed generators have no options to sell unconsumed electricity in the electricity market. The main difficulties lie in limited connection possibilities, the selection of plant locations, and coordination among relevant authorities. Moreover, an awareness campaign would help people to better understand the related regulation and applications.

  6. Cash Accountability in DOD Imprest Funds Maintained by the Office of the Inspector General, DOD

    National Research Council Canada - National Science Library

    Rau, Russell

    1995-01-01

    We are providing this report for your information and use. The audit was made at your request to examine the imprest funds maintained within the Office of the Inspector General, DoD, Arlington, Virginia...

  7. Committing to coal and gas: Long-term contracts, regulation, and fuel switching in power generation

    Science.gov (United States)

    Rice, Michael

    Fuel switching in the electricity sector has important economic and environmental consequences. In the United States, the increased supply of gas during the last decade has led to substantial switching in the short term. Fuel switching is constrained, however, by the existing infrastructure. The power generation infrastructure, in turn, represents commitments to specific sources of energy over the long term. This dissertation explores fuel contracts as the link between short-term price response and long-term plant investments. Contracting choices enable power plant investments that are relationship-specific, often regulated, and face uncertainty. Many power plants are subject to both hold-up in investment and cost-of-service regulation. I find that capital bias is robust when considering either irreversibility or hold-up due to the uncertain arrival of an outside option. For sunk capital, the rental rate is inappropriate for determining capital bias. Instead, capital bias depends on the regulated rate of return, discount rate, and depreciation schedule. If policies such as emissions regulations increase fuel-switching flexibility, this can lead to capital bias. Cost-of-service regulation can shorten the duration of a long-term contract. From the firm's perspective, the existing literature provides limited guidance when bargaining and writing contracts for fuel procurement. I develop a stochastic programming framework to optimize long-term contracting decisions under both endogenous and exogenous sources of hold-up risk. These typically include policy changes, price shocks, availability of fuel, and volatility in derived demand. For price risks, the optimal contract duration is the moment when the expected benefits of the contract are just outweighed by the expected opportunity costs of remaining in the contract. I prove that imposing early renegotiation costs decreases contract duration. Finally, I provide an empirical approach to show how coal contracts can limit

  8. Regulation characteristics of oxide generation and formaldehyde removal by using volume DBD reactor

    Science.gov (United States)

    Bingyan, CHEN; Xiangxiang, GAO; Ke, CHEN; Changyu, LIU; Qinshu, LI; Wei, SU; Yongfeng, JIANG; Xiang, HE; Changping, ZHU; Juntao, FEI

    2018-02-01

    Discharge plasmas in air can be accompanied by ultraviolet (UV) radiation and electron impact, which can produce large numbers of reactive species such as hydroxyl radical (OH·), oxygen radical (O·), ozone (O3), and nitrogen oxides (NO x ), etc. The composition and dosage of reactive species usually play an important role in the case of volatile organic compounds (VOCs) treatment with the discharge plasmas. In this paper, we propose a volume discharge setup used to purify formaldehyde in air, which is configured by a plate-to-plate dielectric barrier discharge (DBD) channel and excited by an AC high voltage source. The results show that the relative spectral-intensity from DBD cell without formaldehyde is stronger than the case with formaldehyde. The energy efficiency ratios (EERs) of both oxides yield and formaldehyde removal can be regulated by the gas flow velocity in DBD channel, and the most desirable processing effect is the gas flow velocity within the range from 2.50 to 3.33 m s-1. Moreover, the EERs of both the generated dosages of oxides (O3 and NO2) and the amount of removed formaldehyde can also be regulated by both of the applied voltage and power density loaded on the DBD cell. Additionally, the EERs of both oxides generation and formaldehyde removal present as a function of normal distribution with increasing the applied power density, and the peak of the function is appeared in the range from 273.5 to 400.0 W l-1. This work clearly demonstrates the regulation characteristic of both the formaldehyde removal and oxides yield by using volume DBD, and it is helpful in the applications of VOCs removal by using discharge plasma.

  9. Many ways to be small: different environmental regulators of size generate distinct scaling relationships in Drosophila melanogaster

    OpenAIRE

    Shingleton, Alexander W.; Estep, Chad M.; Driscoll, Michael V.; Dworkin, Ian

    2009-01-01

    Static allometries, the scaling relationship between body and trait size, describe the shape of animals in a population or species, and are generated in response to variation in genetic or environmental regulators of size. In principle, allometries may vary with the different size regulators that generate them, which can be problematic since allometric differences are also used to infer patterns of selection on morphology. We test this hypothesis by examining the patterns of scaling in Drosop...

  10. Regulation and Measurement of the Heat Generated by Automatic Tooth Preparation in a Confined Space.

    Science.gov (United States)

    Yuan, Fusong; Zheng, Jianqiao; Sun, Yuchun; Wang, Yong; Lyu, Peijun

    2017-06-01

    The aim of this study was to assess and regulate heat generation in the dental pulp cavity and circumambient temperature around a tooth during laser ablation with a femtosecond laser in a confined space. The automatic tooth preparing technique is one of the traditional oral clinical technology innovations. In this technique, a robot controlled an ultrashort pulse laser to automatically complete the three-dimensional teeth preparing in a confined space. The temperature control is the main measure for protecting the tooth nerve. Ten tooth specimens were irradiated with a femtosecond laser controlled by a robot in a confined space to generate 10 teeth preparation. During the process, four thermocouple sensors were used to record the pulp cavity and circumambient environment temperatures with or without air cooling. A statistical analysis of the temperatures was performed between the conditions with and without air cooling (p heat generated in the pulp cavity was lower than the threshold for dental pulp damage. These results indicate that femtosecond laser ablation with air cooling might be an appropriate method for automatic tooth preparing.

  11. Real-time transient stabilization and voltage regulation of power generators with unknown mechanical power input

    International Nuclear Information System (INIS)

    Kenne, Godpromesse; Goma, Raphael; Nkwawo, Homere; Lamnabhi-Lagarrigue, Francoise; Arzande, Amir; Vannier, Jean Claude

    2010-01-01

    A nonlinear adaptive excitation controller is proposed to enhance the transient stability and voltage regulation of synchronous generators with unknown power angle and mechanical power input. The proposed method is based on a standard third-order model of a synchronous generator which requires only information about the physical available measurements of relative angular speed, active electric power, infinite bus and generator terminal voltages. The operating conditions are computed online using the above physical available measurements, the terminal voltage reference value and the estimate of the mechanical power input. The proposed design is therefore capable of providing satisfactory voltage in the presence of unknown variations of the power system operating conditions. Using the concept of sliding mode equivalent control techniques, a robust decentralized adaptive controller which insures the exponential convergence of the outputs to the desired ones, is obtained. Real-time experimental results are reported, comparing the performance of the proposed adaptive nonlinear control scheme to one of the conventional AVR/PSS controller. The high simplicity of the overall adaptive control scheme and its robustness with respect to line impedance variation including critical unbalanced operating condition and temporary turbine fault, constitute the main positive features of the proposed approach.

  12. Regulator of G-protein signaling 18 controls both platelet generation and function.

    Directory of Open Access Journals (Sweden)

    Nathalie Delesque-Touchard

    Full Text Available RGS18 is a myeloerythroid lineage-specific regulator of G-protein signaling, highly expressed in megakaryocytes (MKs and platelets. In the present study, we describe the first generation of a RGS18 knockout mouse model (RGS18-/-. Interesting phenotypic differences between RGS18-/- and wild-type (WT mice were identified, and show that RGS18 plays a significant role in both platelet generation and function. RGS18 deficiency produced a gain of function phenotype in platelets. In resting platelets, the level of CD62P expression was increased in RGS18-/- mice. This increase correlated with a higher level of plasmatic serotonin concentration. RGS18-/- platelets displayed a higher sensitivity to activation in vitro. RGS18 deficiency markedly increased thrombus formation in vivo. In addition, RGS18-/- mice presented a mild thrombocytopenia, accompanied with a marked deficit in MK number in the bone marrow. Analysis of MK maturation in vitro and in vivo revealed a defective megakaryopoiesis in RGS18-/- mice, with a lower bone marrow content of only the most committed MK precursors. Finally, RGS18 deficiency was correlated to a defect of platelet recovery in vivo under acute conditions of thrombocytopenia. Thus, we highlight a role for RGS18 in platelet generation and function, and provide additional insights into the physiology of RGS18.

  13. Real-time transient stabilization and voltage regulation of power generators with unknown mechanical power input

    Energy Technology Data Exchange (ETDEWEB)

    Kenne, Godpromesse, E-mail: gokenne@yahoo.co [Laboratoire d' Automatique et d' Informatique Appliquee (LAIA), Departement de Genie Electrique, Universite de Dschang, B.P. 134 Bandjoun (Cameroon); Goma, Raphael, E-mail: raphael.goma@lss.supelec.f [Laboratoire des Signaux et Systemes (L2S), CNRS-SUPELEC, Universite Paris XI, 3 Rue Joliot Curie, 91192 Gif-sur-Yvette (France); Nkwawo, Homere, E-mail: homere.nkwawo@iutv.univ-paris13.f [Departement GEII, Universite Paris XIII, 99 Avenue Jean Baptiste Clement, 93430 Villetaneuse (France); Lamnabhi-Lagarrigue, Francoise, E-mail: lamnabhi@lss.supelec.f [Laboratoire des Signaux et Systemes (L2S), CNRS-SUPELEC, Universite Paris XI, 3 Rue Joliot Curie, 91192 Gif-sur-Yvette (France); Arzande, Amir, E-mail: Amir.arzande@supelec.f [Departement Energie, Ecole Superieure d' Electricite-SUPELEC, 3 Rue Joliot Curie, 91192 Gif-sur-Yvette (France); Vannier, Jean Claude, E-mail: Jean-claude.vannier@supelec.f [Departement Energie, Ecole Superieure d' Electricite-SUPELEC, 3 Rue Joliot Curie, 91192 Gif-sur-Yvette (France)

    2010-01-15

    A nonlinear adaptive excitation controller is proposed to enhance the transient stability and voltage regulation of synchronous generators with unknown power angle and mechanical power input. The proposed method is based on a standard third-order model of a synchronous generator which requires only information about the physical available measurements of relative angular speed, active electric power, infinite bus and generator terminal voltages. The operating conditions are computed online using the above physical available measurements, the terminal voltage reference value and the estimate of the mechanical power input. The proposed design is therefore capable of providing satisfactory voltage in the presence of unknown variations of the power system operating conditions. Using the concept of sliding mode equivalent control techniques, a robust decentralized adaptive controller which insures the exponential convergence of the outputs to the desired ones, is obtained. Real-time experimental results are reported, comparing the performance of the proposed adaptive nonlinear control scheme to one of the conventional AVR/PSS controller. The high simplicity of the overall adaptive control scheme and its robustness with respect to line impedance variation including critical unbalanced operating condition and temporary turbine fault, constitute the main positive features of the proposed approach.

  14. Vulnerability of US thermoelectric power generation to climate change when incorporating state-level environmental regulations

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Lu; Hejazi, Mohamad; Li, Hongyi; Forman, Barton; Zhang, Xiao

    2017-07-10

    This study explores the interactions between climate and thermoelectric generation in the U.S. by coupling an Earth System Model with a thermoelectric power generation model. We validated model simulations of power production for selected power plants (~44% of existing thermoelectric capacity) against reported values. In addition, we projected future usable capacity for existing power plants under two different climate change scenarios. Results indicate that climate change alone may reduce average thermoelectric generating capacity by 2%-3% by the 2060s. Reductions up to 12% are expected if environmental requirements are enforced without waivers for thermal variation. This study concludes that the impact of climate change on the U.S. thermoelectric power system is less than previous estimates due to an inclusion of a spatially-disaggregated representation of environmental regulations and provisional variances that temporarily relieve power plants from permit requirements. This work highlights the significance of accounting for legal constructs in which the operation of power plants are managed, and underscores the effects of provisional variances in addition to environmental requirements.

  15. Performance augmentation with vortex generators: Design and testing for stall-regulated AWT-26 turbine

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, D.A. [Advanced Wind Turbines Inc., Seattle, WA (United States)

    1996-12-31

    A study investigated the use of vortex generators (VGs) for performance augmentation of the stall-regulated AWT-26 wind turbine. Based on wind-tunnel results and analysis, a VG array was designed for and tested on the AWT-26 prototype, designated Pt. Performance and loads data were measured for P1, both with and without VGs installed. The turbine performance with VGs met most of the design requirements; power output was increased at moderate wind speeds with a minimal effect on peak power. However, VG drag penalties caused a loss in power output for low wind speeds, such that performance with VGs resulted in a net decrease in AEP for wind speed sites up to 8.5 m/s. 8 refs., 8 figs., 3 tabs.

  16. Main tasks of studying strong regulation of excitation of complex electrical system generators

    Energy Technology Data Exchange (ETDEWEB)

    Gruzdev, I.A.; Yekimova, M.M.

    1982-01-01

    A survey is made of the current state of studies of the damping properties of complex electricity systems. The calculation programs of stability are based on frequency methods using the method of D-division. Now, when ARV of strong effect dominates at the SG, the task of coordinating their adjustments develops. Consequently, the following questions are discussed: study of the properties of quality functional with several points of regulation in the circuits of different structure; development of the efficient procedures for coordinating the ARV adjustment of the related energy systems; and creation of resources for solving these tasks. Results are presented of coordinating the ARV adjustments of the generators of the 3-machine electricity system. As an example, nonlinear relationships are shown between the obtained degree of stability and the coefficient of stabilization.

  17. Modernization of the Light generators voltage regulation systems and evaluation of the necessity of stabilizers

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Paulo R.G.M. de; Oliveira Aires, Joao C. de; Nascimento, Anselmo R; Almeida, Antonio J.B. de [Light Servicos de Eletricidade SA, Rio de Janeiro, RJ (Brazil); Souza Pedroso, Alquindar de [Centro de Pesquisas de Energia Eletrica, Rio de Janeiro, RJ (Brazil)

    1988-12-31

    This paper presents the studies and solutions adopted by Light to mitigate the problems relative to the lack of power and voltage oscillation damping in the Rio de Janeiro area (Southeast Brazil) for the contingencies of South/Southeast interconnection loss and 500 kV transmission line loss. The characteristics of Light generating system, comprised of the Fontes Velha, Fontes Nova, Ilha dos Pombos, Nilo Pecanha, and Pereira Passos hydroelectric plants are shown. Excitation/Voltage regulation alternatives are also presented. The performance of proposed equipment is discussed based on some simulation analysis. Finally, some alternatives for improvement of Rio de Janeiro area dynamic performance are suggested. 4 refs., 3 tabs., 5 figs.

  18. Chemically Regulated ROS Generation from Gold Nanoparticles for Enzyme-Free Electrochemiluminescent Immunosensing.

    Science.gov (United States)

    Higashi, Yui; Mazumder, Joyotu; Yoshikawa, Hiroyuki; Saito, Masato; Tamiya, Eiichi

    2018-04-17

    In the present work, we report on an enzyme-free electrochemiluminescent (ECL) immunosensing scheme utilizing the catalytic generation of reactive oxygen species (ROS) from gold nanoparticles (AuNPs) (diameter ≥5 nm) dispersed in aqueous solutions of trishydroxymethylaminomethane (Tris). First, to examine this catalytic pathway in detail, the effects of various factors such as the AuNP size and concentration, dispersant type and concentration, and dissolved oxygen were investigated using the electrochemiluminescence (ECL) of luminol. It was found that the catalytic generation of ROS from AuNPs can be regulated chemically by altering conditions such as the type, concentration, and pH of the solution that the AuNPs are dispersed in. Under the best conditions studied in this work, the AuNPs displayed high catalytic activity toward ROS generation, with an estimated apparent turnover number per AuNP of 0.1 s -1 , comparable to those of several common peroxide-producing enzymes. Following these studies, this phenomenon was applied to develop a one-step enzyme-free ECL immunosensor based on sandwiching the target analyte using antibody-conjugated magnetic beads (MB) and AuNPs. Using IgA as a model analyte, the developed immunosensor was able to detect the target in the range of 1 ng/mL to 10 μg/mL, with the lower detection limit being comparable to those of commercial assays for the same target. Altering the antibodies used to modify the MB and AuNPs could further improve the detection limit as well as expand the applicability of this immunoassay to the detection of other analytes.

  19. Helium generated cold plasma finely regulates activation of human fibroblast-like primary cells.

    Directory of Open Access Journals (Sweden)

    Paola Brun

    Full Text Available Non-thermal atmospheric pressure plasmas are being developed for a wide range of health care applications, including wound healing. However in order to exploit the potential of plasma for clinical applications, the understanding of the mechanisms involved in plasma-induced activation of fibroblasts, the cells active in the healing process, is mandatory. In this study, the role of helium generated plasma in the tissue repairing process was investigated in cultured human fibroblast-like primary cells, and specifically in hepatic stellate cells and intestinal subepithelial myofibroblasts. Five minutes after treatment, plasma induced formation of reactive oxygen species (ROS in cultured cells, as assessed by flow cytometric analysis of fluorescence-activated 2',7'-dichlorofluorescein diacetate probe. Plasma-induced intracellular ROS were characterized by lower concentrations and shorter half-lives with respect to hydrogen peroxide-induced ROS. Moreover ROS generated by plasma treatment increased the expression of peroxisome proliferator activated receptor (PPAR-γ, nuclear receptor that modulates the inflammatory responses. Plasma exposure promoted wound healing in an in vitro model and induced fibroblast migration and proliferation, as demonstrated, respectively, by trans-well assay and partitioning between daughter cells of carboxyfluorescein diacetate succinimidyl ester fluorescent dye. Plasma-induced fibroblast migration and proliferation were found to be ROS-dependent as cellular incubation with antioxidant agents (e.g. N-acetyl L-cysteine cancelled the biological effects. This study provides evidence that helium generated plasma promotes proliferation and migration in liver and intestinal fibroblast-like primary cells mainly by increasing intracellular ROS levels. Since plasma-evoked ROS are time-restricted and elicit the PPAR-γ anti-inflammatory molecular pathway, this strategy ensures precise regulation of human fibroblast activation and

  20. DoD Cybersecurity Discipline Implementation Plan

    Science.gov (United States)

    2016-02-01

    a user: 1) something the user knows, such as a password or key code; 2) something the user is, such as biometrics ; and 3) something the user has...between weak passwords and account takeovers via brute force attacks are well-established. Traditionally, individuals requiring access to DoD information...networks had to create network- and system-specific user names and passwords to access information online. DoDI 8520.03 (Reference (f)) requires

  1. Reconsidering the European regulation of merchant transmission investment in light of the third energy package: The role of dominant generators

    International Nuclear Information System (INIS)

    Hauteclocque, Adrien de; Rious, Vincent

    2011-01-01

    The regulation of merchant transmission investment (MTI) has become an important issue in the EU electricity sector, subsequent to the granting of authorizations by European authorities to five merchant projects: BritNed, Estlink, the East West Cables, NorGer and recently a merchant line connecting Italy and Austria. The creation of a new Agency for the Cooperation of Energy Regulators (ACER) at the EU level, which has decision-making powers on MTI, therefore presents a unique opportunity to question and re-design the current European policy. This paper shows that the recent decisions concerning MTI may suffer a strong bias against dominant electricity generators while incumbent Transmission System Operators (TSOs) or new entrant TSOs are generally favored by national regulators and the European Commission (EC). This strategy is misguided as it fails to recognize both the new incentives of generators to develop MTI and the conflict of interest between the regulated and non-regulated activities of incumbent TSOs. Letting dominant generators undertake MTI is indeed generally beneficial as long as potential abuses of dominance are mitigated. To deter possible anti-competitive effects, we propose a new and feasible allocation of regulatory powers based on a clear demarcation between the market monitoring powers of ACER and the antitrust powers of the EC. - Highlights: → We compare TSOs and generators as merchant transmission investors in Europe. → We find a bias among regulators against the involvement of generators. → The conflict of interest with the regulated activities of TSOs is under-estimated. → Investment by generators is preferable provided market manipulation is deterred. → We propose a new allocation of regulatory powers to make it possible.

  2. DOD Inventory of Contracted Services: Timely Decisions and Further Actions Needed to Address Long Standing Issues

    Science.gov (United States)

    2016-10-01

    official. In its transmittal letter for fiscal year 2015, the Air Force stated that it first needs to better understand the roles and responsibilities... Statement to the National Defense Authorization Act for Fiscal Year 2016 mandated that DOD report on the approach the department is taking to comply...Inventory Page 36 GAO-17-17 Service Contract Inventories DOD’s Financial Management Regulation provided, among other things, guidance to

  3. 78 FR 64265 - Hours of Service of Drivers: U.S. Department of Defense (DOD); Application for Exemption

    Science.gov (United States)

    2013-10-28

    ... break provision of the Agency's hours-of-service (HOS) regulations for commercial motor vehicle (CMV... requirements in Sec. 395.3(a)(3)(ii). SDDC states that it requires continuous attendance and surveillance of... surveillance. Inspecting carrier facilities and corporate headquarters for compliance with DOD and DOT...

  4. 48 CFR 252.244-7000 - Subcontracts for Commercial Items and Commercial Components (DoD Contracts).

    Science.gov (United States)

    2010-10-01

    ... under this contract: (a) 252.225-7009 Restriction on Acquisition of Certain Articles Containing... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Subcontracts for Commercial Items and Commercial Components (DoD Contracts). 252.244-7000 Section 252.244-7000 Federal...

  5. 32 CFR 635.9 - Guidelines for disclosure within DOD.

    Science.gov (United States)

    2010-07-01

    ... for disclosure within DOD. (a) Criminal record information contained in military police documents will... limit the dissemination of information between military police, the USACIDC, and other law enforcement...

  6. Crossing the Technology Adoption Chasm: Implications for DoD

    National Research Council Canada - National Science Library

    Coughlan, Peter; Dew, Nicholas; Gates, William

    2008-01-01

    .... To better understand DOD's technology adoption challenges, we review the technology diffusion literature to identify factors associated with successful and unsuccessful technology adoption processes...

  7. Design of reactive power regulator of synchronous generators by considering grid impedance angle for characteristic index objectives

    DEFF Research Database (Denmark)

    Raboni, Pietro; Chaudhary, Sanjay K.; Chen, Zhe

    2016-01-01

    functions are formulated on the basis of the integral of an error. This difference makes them suitable for the cases where the entire step-response data series are unavailable. The performances of differently tuned regulators are compared considering a test system including a 100 kW Diesel Generator Set......Effects of low reactance to resistance ratio in distribution networks are widely studied but little work dealing with the tuning of voltage and reactive power regulators of small synchronous generators has been reported. This study endeavours the design of a proportional integral controller...

  8. Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonization.

    Science.gov (United States)

    Alam, M Samiul; Costales, Matthew G; Cavanaugh, Christopher; Williams, Kristina

    2015-05-05

    Adenosine, an immunomodulatory biomolecule, is produced by the ecto-enzymes CD39 (nucleoside triphosphate dephosphorylase) and CD73 (ecto-5'-nucleotidase) by dephosphorylation of extracellular ATP. CD73 is expressed by many cell types during injury, infection and during steady-state conditions. Besides host cells, many bacteria also have CD39-CD73-like machinery, which helps the pathogen subvert the host inflammatory response. The major function for adenosine is anti-inflammatory, and most recent research has focused on adenosine's control of inflammatory mechanisms underlying various autoimmune diseases (e.g., colitis, arthritis). Although adenosine generated through CD73 provides a feedback to control tissue damage mediated by a host immune response, it can also contribute to immunosuppression. Thus, inflammation can be a double-edged sword: it may harm the host but eventually helps by killing the invading pathogen. The role of adenosine in dampening inflammation has been an area of active research, but the relevance of the CD39/CD73-axis and adenosine receptor signaling in host defense against infection has received less attention. Here, we review our recent knowledge regarding CD73 expression during murine Salmonellosis and Helicobacter-induced gastric infection and its role in disease pathogenesis and bacterial persistence. We also explored a possible role for the CD73/adenosine pathway in regulating innate host defense function during infection.

  9. Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors

    Directory of Open Access Journals (Sweden)

    Delphine Delaunay

    2014-01-01

    Full Text Available The regulation of asymmetric cell division (ACD during corticogenesis is incompletely understood. We document that spindle-size asymmetry (SSA between the two poles occurs during corticogenesis and parallels ACD. SSA appears at metaphase and is maintained throughout division, and we show it is necessary for proper neurogenesis. Imaging of spindle behavior and division outcome reveals that neurons preferentially arise from the larger-spindle pole. Mechanistically, SSA magnitude is controlled by Wnt7a and Vangl2, both members of the Wnt/planar cell polarity (PCP-signaling pathway, and relayed to the cell cortex by P-ERM proteins. In vivo, Vangl2 and P-ERM downregulation promotes early cell-cycle exit and prevents the proper generation of late-born neurons. Thus, SSA is a core component of ACD that is conserved in invertebrates and vertebrates and plays a key role in the tight spatiotemporal control of self-renewal and differentiation during mammalian corticogenesis.

  10. Trait Affect, Emotion Regulation, and the Generation of Negative and Positive Interpersonal Events.

    Science.gov (United States)

    Hamilton, Jessica L; Burke, Taylor A; Stange, Jonathan P; Kleiman, Evan M; Rubenstein, Liza M; Scopelliti, Kate A; Abramson, Lyn Y; Alloy, Lauren B

    2017-07-01

    Positive and negative trait affect and emotion regulatory strategies have received considerable attention in the literature as predictors of psychopathology. However, it remains unclear whether individuals' trait affect is associated with responses to state positive affect (positive rumination and dampening) or negative affect (ruminative brooding), or whether these affective experiences contribute to negative or positive interpersonal event generation. Among 304 late adolescents, path analyses indicated that individuals with higher trait negative affect utilized dampening and brooding rumination responses, whereas those with higher trait positive affect engaged in rumination on positive affect. Further, there were indirect relationships between trait negative affect and fewer positive and negative interpersonal events via dampening, and between trait positive affect and greater positive and negative interpersonal events via positive rumination. These findings suggest that individuals' trait negative and positive affect may be associated with increased utilization of emotion regulation strategies for managing these affects, which may contribute to the occurrence of positive and negative events in interpersonal relationships. Copyright © 2017. Published by Elsevier Ltd.

  11. Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Seung Min, E-mail: smjeong@catholic.ac.kr [Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 137-701 (Korea, Republic of); Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 137-701 (Korea, Republic of); Hwang, Sunsook; Seong, Rho Hyun [School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742 (Korea, Republic of)

    2016-03-11

    The transferrin receptor (TfR1) is upregulated in malignant cells and its expression is associated with cancer progression. Because of its pre-eminent role in cell proliferation, TfR1 has been an important target for the development of cancer therapy. Although TfR1 is highly expressed in pancreatic cancers, what it carries out in these refractory cancers remains poorly understood. Here we report that TfR1 supports mitochondrial respiration and ROS production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is required for their tumorigenic growth. Elevated TfR1 expression in PDAC cells contributes to oxidative phosphorylation, which allows for the generation of ROS. Importantly, mitochondrial-derived ROS are essential for PDAC growth. However, exogenous iron supplement cannot rescue the defects caused by TfR1 knockdown. Moreover, we found that TfR1 expression determines PDAC cells sensitivity to oxidative stress. Together, our findings reveal that TfR1 can contribute to the mitochondrial respiration and ROS production, which have essential roles in growth and survival of pancreatic cancer. - Highlights: • Pancreatic ductal adenocarcinoma (PDAC) exhibits an elevated transferrin receptor (TfR1) expression in comparison with non-transformed pancreatic cells. • TfR1 is required for PDAC growth by regulating mitochondrial respiration and ROS production. • TfR1 functions as a determinant of cell viability to oxidative stress in PDAC cells.

  12. Spatial regulation of a common precursor from two distinct genes generates metabolite diversity

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Chun-Jun; Sun, Wei-Wen; Bruno, Kenneth S.; Oakley, Berl R.; Keller, Nancy P.; Wang, Clay C.

    2015-07-13

    In secondary metabolite biosynthesis, core synthetic genes such as polyketide synthase genes or non-ribosomal peptide synthase genes usually encode proteins that generate various backbone precursors. These precursors are modified by other tailoring enzymes to yield a large variety of different secondary metabolites. The number of core synthesis genes in a given species correlates, therefore, with the number of types of secondary metabolites the organism can produce. In our study, heterologous expression of all the A. terreus NRPS-like genes showed that two NRPS-like proteins, encoded by atmelA and apvA, release the same natural product, aspulvinone E. More interestingly, further experiments revealed that the aspulvinone E produced by two different genes accumulates in different fungal compartments. And this spatial control of aspulvinone E production is likely to be regulated by their own specific promoters. Comparative genomics indicates that atmelA and apvA might share a same ancestral gene and the gene apvA is inserted in a highly conserved region in Aspergillus species that contains genes coding for life-essential proteins. The study also identified one trans-prenyltransferase AbpB which is capable of prenylating two different substrates aspulvinones and butyrolactones. In total, our study shows the first example in which the locally distribution of the same natural product could lead to its incorporation into different SM pathways.

  13. Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation

    International Nuclear Information System (INIS)

    Jeong, Seung Min; Hwang, Sunsook; Seong, Rho Hyun

    2016-01-01

    The transferrin receptor (TfR1) is upregulated in malignant cells and its expression is associated with cancer progression. Because of its pre-eminent role in cell proliferation, TfR1 has been an important target for the development of cancer therapy. Although TfR1 is highly expressed in pancreatic cancers, what it carries out in these refractory cancers remains poorly understood. Here we report that TfR1 supports mitochondrial respiration and ROS production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is required for their tumorigenic growth. Elevated TfR1 expression in PDAC cells contributes to oxidative phosphorylation, which allows for the generation of ROS. Importantly, mitochondrial-derived ROS are essential for PDAC growth. However, exogenous iron supplement cannot rescue the defects caused by TfR1 knockdown. Moreover, we found that TfR1 expression determines PDAC cells sensitivity to oxidative stress. Together, our findings reveal that TfR1 can contribute to the mitochondrial respiration and ROS production, which have essential roles in growth and survival of pancreatic cancer. - Highlights: • Pancreatic ductal adenocarcinoma (PDAC) exhibits an elevated transferrin receptor (TfR1) expression in comparison with non-transformed pancreatic cells. • TfR1 is required for PDAC growth by regulating mitochondrial respiration and ROS production. • TfR1 functions as a determinant of cell viability to oxidative stress in PDAC cells.

  14. Voltage optimal regulation of distribution power network with a source of dispersed generation owned by either one or several owners

    Directory of Open Access Journals (Sweden)

    Олександр Станиславович Яндульський

    2015-11-01

    Full Text Available The criteria of optimal voltage regulation in the electrical distribution network (EDN with a source of dispersed generation (SDG were formulated, if they belong to either one or different owners, taking into account the peculiarities of voltage regulation by means of the SDG and the OLTC system of the transformer. It was found out that under the conditions of economic unprofitability of voltage regulation, in accordance with the above criteria, the owners should take up coordinated work – the general objective function of voltage regulation to improve the effectiveness of regulation and achieve cost-effectiveness. The criteria of optimal voltage regulation if EDN and SDG belong to one owner were formulated. If their work becomes coordinated it is necessary to know exactly which transformer must be regulated; so a transformer with OLTC system should be chosen. Selection sequence is based on the calculation of the sensitivity of the voltage at the nodes within SDG with respect to OLTC position. The proposed OLTC system and SDG coordinated work makes it possible to increase the effectiveness of voltage regulation in the EDN with SDG under different conditions of ownership and increase the economic profitability of regulation

  15. 76 FR 22849 - DoD Unclassified Controlled Nuclear Information (UCNI)

    Science.gov (United States)

    2011-04-25

    ... containing DoD UCNI information. (8) DoD UCNI processed, stored, or produced on stand-alone or networked... marked as having DoD UCNI may be reproduced minimally without permission of the originator and consistent...

  16. DoD Installation Energy Security: Evolving to a Smart Grid

    Science.gov (United States)

    2012-03-20

    located at the Naval Air Weapons Station in China Lake, California. This series of geothermal power plants produces a peak power output of 270 megawatts...initiatives are driving the DoD to invest significantly in renewable energy resources like solar, wind, and geothermal , as well as energy efficient vehicles...hydroelectric, geothermal ) resources. The most common and largest forms of electrical generation come from power plants that use fossil fuels

  17. DOD Financial Management: Improvement Needed in DOD Components’ Implementation of Audit Readiness Effort

    Science.gov (United States)

    2011-09-01

    DOD Financial Management Abbreviations AFB Air Force Base COSO Committee of Sponsoring Organizations of the Treadway... Management and mismanagement.11 All of DOD’s programs on GAO’s High- Risk List relate to its business operations, including systems and processes... Management maintains audit readiness through risk -based periodic testing of internal controls utilizing the OMB Circular No. A-123, Appendix A

  18. DoD Fuel Facilities Criteria

    Science.gov (United States)

    2015-04-27

    Pantograph Feb-2010 UFGS 33 58 00 Leak Detection for Fueling Systems Apr-2008 UFGS 33 52 43.13 Aviation Fuel Piping Feb-2010 UFGS 33 59 00 Tightness of... Pipeline Pressure Testing Guidelines  Specifications  Questions 2 7/12/2017 3 7/12/2017 DoD Fuels Facilities Documents  Unified...UFGS)  Most in the 33 nn nn series  Associated with Standard Designs  Available on WBDG site  Coating Systems 4 7/12/2017 Pipeline

  19. DOD Security Cooperation: An Overview of Authorities and Issues

    Science.gov (United States)

    2016-08-23

    Syria, Ukraine .................................................................................................... 7 Global and Regional, Non... crisis intervention, and as an exit strategy for post-9/11 military campaigns. 9 To implement such concepts, DOD requested that Congress grant new...Africa, Iraq, Syria, Ukraine Congress has provided DOD with several authorities to support U.S. military operations or other military efforts in

  20. DOD low energy model installation program

    International Nuclear Information System (INIS)

    Fournier, D.F. Jr.

    1993-01-01

    The Model Low Energy Installation Program is a demonstration of an installation-wide, comprehensive energy conservation program that meets the Department of Defense (DoD) energy management goals of reducing energy usage and costs by at least 20%. It employs the required strategies for meeting these goals, quantifies the environmental compliance benefits resulting from energy conservation and serves as a prototype for DoD wide application. This project will develop both analysis tools and implementation procedures as well as demonstrate the effectiveness of a comprehensive, coordinated energy conservation program based on state-of-the-art technologies. A military installation is in reality a small to medium sized city. It generally has a complete utilities infrastructure including water supply and distribution, sewage collection and treatment, electrical supply and distribution, central heating and cooling plants with thermal distribution, and a natural gas distribution system. These utilities are quite extensive and actually consume about 10-15% of the energy on the facility not counting the energy going into the central plants

  1. Current regulator for the stabilization of an electrostatic Van de Graaff generator

    International Nuclear Information System (INIS)

    Gabet, A.; Taieb, J.

    1953-01-01

    In a previous report (CEA report number 46) we described a current regulator destined to enslave the current of charge of the strap of a model of Van de Graaff. We will now describe the regulator destined to the 5 MeV Van de Graaff built in the Nuclear center of Saclay. (author) [fr

  2. A High Performance System With Explicit Incorporation of ATC Regulations to Generate Contingency Plans for UAVs with Lost Communication, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose a comprehensive and systematic contingency plan generation framework to deal with lost communication in UAVs. ATC regulations are explicitly incorporated...

  3. A comparison of computer- and hand-generated clinical dental notes with statutory regulations in record keeping.

    Science.gov (United States)

    McAndrew, R; Ban, J; Playle, R

    2012-02-01

    Dental patient records should be of high quality, contain information to allow for good continuity of care and clinical defence (should the need ever arise) and, ideally, facilitate clinical audit. Handwritten dental records have been assessed for their compliance to statutory regulations, but the same cannot be levelled at computer-generated notes. This study aimed to compare and analyse the compliance of both methods of data recording with statutory regulations. Fifty consecutive sets of handwritten notes and 50 sets of computer-generated notes were audited for compliance with a number of legal requirements and desirable characteristics for dental records and the results compared. The standard set for compliance with all characteristics was 100%. The computer-generated notes satisfied the set standard for 8 of the 11 legal requirements and three of six desirable characteristics. The handwritten notes satisfied the set standard for 1 of 11 legal requirements and none of the desirable characteristics. A statistical difference (using a 95% confidence interval) between the two methods was observed in 5 of 11 legal characteristics and three of six desirable characteristics, all of which were in favour of computer-generated notes. Within the limitations of this study, computer-generated notes achieved a much higher compliance rate with the set parameters, making defence in cases of litigation, continuity of care and clinical audit easier and more efficient. © 2011 John Wiley & Sons A/S.

  4. Two essays on electricity markets: Entry into hydroelectric generation industry and the political cycle of regulated prices

    Science.gov (United States)

    Moita, Rodrigo Menon Simoes

    This dissertation is about the electricity industry and the problems that arise with the liberalization and de-regulation of the industry. Characteristics intrinsic to the electricity market create problems that can compromise an efficient functioning of this market. Each of the two chapters of this dissertation focus on a specific aspect of this industry. The first chapter analyzes entry in the hydroelectric generation industry. The operation of a generator upstream regularizes the river flow for generators located downstream on the same river, increasing the production capacity of the latter. This positive externality increases the attractiveness of the locations downstream whenever a generator decides to enter upstream. Therefore, the entry decision of a generator in a given location may affect all entry decisions in potential locations for plants located downstream. I first model the problem of generators located in cascade on the same river and show the positive effect of the externality. Second, I use a panel of data on investment decisions of hydro-generation firms to estimate an entry model that takes into account the effect of the externality generated by entry upriver. The results show a positive incentive to locate downstream from existing plants and from locations where entry is likely to occur. Location characteristics also play an important role on the entrants' decisions. The model provides estimates of the average expected market price across the different years covered by the sample and shows that it rose one year before the energy crisis of 2001, evidencing that the market anticipated the crisis. This result has important implications on the evaluation of the Brazilian market design. It shows that entry responded to a rise in expectations about excess demand in the future, contradicting the argument that the crisis was a consequence of mis-designed market institutions. The second chapter deals with the problem of the political cycle in regulated

  5. 77 FR 55475 - Federal Acquisition Regulation; Information Collection; Permits, Authorities, or Franchises

    Science.gov (United States)

    2012-09-10

    ...; Information Collection; Permits, Authorities, or Franchises AGENCY: Department of Defense (DOD), General... approved information collection requirement concerning permits, authorities, or franchises for regulated..., Authorities, or Franchises, by any of the following methods: Regulations.gov : http://www.regulations.gov...

  6. Counterfeit Parts: DOD Needs to Improve Reporting and Oversight to Reduce Supply Chain Risk

    Science.gov (United States)

    2016-02-01

    agencies and contractors we met with stated that they have encountered counterfeit parts less frequently in the DOD supply chain , in part, because...the DOD supply chain as a method to prevent further counterfeiting.22 DOD and industry officials noted that timely reporting of...COUNTERFEIT PARTS DOD Needs to Improve Reporting and Oversight to Reduce Supply Chain Risk Report to Congressional Committees

  7. Effects of SO2 emission regulations and fuel prices on levellized energy costs for industrial steam generation options

    International Nuclear Information System (INIS)

    Ozdogan, Sibel; Arikol, Mahir

    1992-01-01

    We discuss the impacts of SO 2 emission regulations and fuel prices on levellized energy costs of industrial steam generation options. A computer model called INDUSTEAM has been utilized. The steam-supply options comprise conventional grate-firing, bubbling and circulating fluidized beds, fuel-oil, and natural-gas-fired systems. Fuels of different SO 2 pollution potential have been evaluated assuming six environmental scenarios and varying fuel prices. A capacity range of 10-90 MW th is covered. (author)

  8. New approach in electricity network regulation: an issue on effective integration of distributed generation in electricity supply systems

    International Nuclear Information System (INIS)

    Scheepers, Martin J.J.; Wals, Adrian F.

    2003-11-01

    Technological developments and EU targets for penetration of renewable energy sources (RES) and greenhouse gas (GHG) reduction are decentralising the electricity infrastructure and services. Although, the liberalisation and internationalisation of the European electricity market has resulted in efforts to harmonise transmission pricing and regulation, hardly any initiative exists to consider the opening up and regulation of distribution networks to ensure effective participation of RES and distributed generation (DG) in the internal market. The SUSTELNET project has been created in order to close this policy gap. Its main objective is to develop regulatory roadmaps for the transition to an electricity market and network structure that creates a level playing field between centralised and decentralised generation and that facilitates the integration of RES, within the framework of the liberalisation of the EU electricity market. By analysing the technical, socio-economic and institutional dynamics of the European electricity system and markets, the project identifies the underlying patterns that provide the boundary conditions and levers for policy development to reach long term RES and GHG targets (2020-2030 time frame). This paper presents results of this analytical phase of the SUSTELNET project. Furthermore, preliminary results of the current work in progress are presented. Principles and criteria for a regulatory framework for sustainable electricity systems are discussed, as well as the development of medium to long-term transition strategies/roadmaps for network regulation and market transformation to facilitate the integration of RES and decentralised electricity generating systems.

  9. Beyond CTLA-4 and PD-1, the generation Z of negative checkpoint regulators.

    Directory of Open Access Journals (Sweden)

    Isabelle eLe Mercier

    2015-08-01

    Full Text Available In the last two years, clinical trials with blocking antibodies to the negative checkpoint regulators CTLA-4 and PD-1 have rekindled the hope for cancer immunotherapy. Multiple negative checkpoint regulators protect the host against autoimmune reactions but also restrict the ability of T cells to effectively attack tumors. Releasing these brakes has emerged as an exciting strategy for cancer treatment. Conversely, these pathways can be manipulated to achieve durable tolerance for treatment of autoimmune diseases and transplantation. In the future, treatment may involve combination therapy to target multiple cell types and stages of the adaptive immune responses. In this review, we describe the current knowledge on the recently discovered negative checkpoint regulators, future targets for immunotherapy.

  10. Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators.

    Science.gov (United States)

    Le Mercier, Isabelle; Lines, J Louise; Noelle, Randolph J

    2015-01-01

    In the last two years, clinical trials with blocking antibodies to the negative checkpoint regulators CTLA-4 and PD-1 have rekindled the hope for cancer immunotherapy. Multiple negative checkpoint regulators protect the host against autoimmune reactions but also restrict the ability of T cells to effectively attack tumors. Releasing these brakes has emerged as an exciting strategy for cancer treatment. Conversely, these pathways can be manipulated to achieve durable tolerance for treatment of autoimmune diseases and transplantation. In the future, treatment may involve combination therapy to target multiple cell types and stages of the adaptive immune responses. In this review, we describe the current knowledge on the recently discovered negative checkpoint regulators, future targets for immunotherapy.

  11. The regulation for delivery of subsidies for measures of promoting power source location for nuclear power generating facilities

    International Nuclear Information System (INIS)

    1977-01-01

    The Regulation is based on the prescriptions of the Enforcement Order for the Law for Arrangement of Surrounding Areas of Power Generating Facilities, the Law for Proper Budget Enforcement Concerning Subsidies and its Enforcement Order. These rules apply to the subsidies concerning nuclear power generating facilities, reprocessing facilities and test and examination facilities for nuclear fuel materials used for power generating reactors, reactors used for research on the safety of power generating reactors, and experimental reactors for fast breeder reactors. The limits of subsidies are specified respectively for the cases that a unit of power generating facility or two and more units of such facilities are set up in a local municipality. The subsidies are delivered for the expenses occurred in the period, beginning from the fiscal year when construction of the generating facility concerned starts or the arrangement plan of the concerned project is approved, and ending in the fiscal year when such construction comes to an end. The subsidies are given as evenly as possible in each fiscal year. The applicants of the subsidies file the applications attached with the explanations of the projects to the chief of the competent ministry (Director General of the Science and Technology Agency or the Minister of International Trade and Industry). Terms of delivery, reports submitted by the receivers of the subsidies and other related matters are specified. (Okada, K.)

  12. Five Conditions Commonly Used to Down-regulate Tor Complex 1 Generate Different Physiological Situations Exhibiting Distinct Requirements and Outcomes*

    Science.gov (United States)

    Tate, Jennifer J.; Cooper, Terrance G.

    2013-01-01

    Five different physiological conditions have been used interchangeably to establish the sequence of molecular events needed to achieve nitrogen-responsive down-regulation of TorC1 and its subsequent regulation of downstream reporters: nitrogen starvation, methionine sulfoximine (Msx) addition, nitrogen limitation, rapamycin addition, and leucine starvation. Therefore, we tested a specific underlying assumption upon which the interpretation of data generated by these five experimental perturbations is premised. It is that they generate physiologically equivalent outcomes with respect to TorC1, i.e. its down-regulation as reflected by TorC1 reporter responses. We tested this assumption by performing head-to-head comparisons of the requirements for each condition to achieve a common outcome for a downstream proxy of TorC1 inactivation, nuclear Gln3 localization. We demonstrate that the five conditions for down-regulating TorC1 do not elicit physiologically equivalent outcomes. Four of the methods exhibit hierarchical Sit4 and PP2A phosphatase requirements to elicit nuclear Gln3-Myc13 localization. Rapamycin treatment required Sit4 and PP2A. Nitrogen limitation and short-term nitrogen starvation required only Sit4. G1 arrest-correlated, long-term nitrogen starvation and Msx treatment required neither PP2A nor Sit4. Starving cells of leucine or treating them with leucyl-tRNA synthetase inhibitors did not elicit nuclear Gln3-Myc13 localization. These data indicate that the five commonly used nitrogen-related conditions of down-regulating TorC1 are not physiologically equivalent and minimally involve partially differing regulatory mechanisms. Further, identical requirements for Msx treatment and long-term nitrogen starvation raise the possibility that their effects are achieved through a common regulatory pathway with glutamine, a glutamate or glutamine metabolite level as the sensed metabolic signal. PMID:23935103

  13. Tactical Aircraft. DOD Needs a Joint and Integrated Investment Strategy

    National Research Council Canada - National Science Library

    2007-01-01

    .... DOD has already incurred substantial cost and schedule overruns in its acquisition of new systems, and further delays could require billions of dollars in additional investments to keep legacy...

  14. DOD Review of Flight Safety Critical Threaded Fasteners and Components

    National Research Council Canada - National Science Library

    Granetto, Paul

    2001-01-01

    This audit was conducted in response to allegations made to the Defense Hotline in October 1999, that the DoD acquisition and quality assurance procedures allowed significant amounts of dimensionally...

  15. Logistics: DoD International Personal Property Shipment Rates

    National Research Council Canada - National Science Library

    2002-01-01

    .... The allegation claimed that under current procedures Code of Service 4 DoD was paying excessive costs for ocean transportation on household goods shipments because a third party company purchased...

  16. DOD Military Retirement Health Benefits Liability for FY 1997

    National Research Council Canada - National Science Library

    1998-01-01

    ...) and the Federal Financial Management Act of 1994 (Public Law 103-356). Public Law 103-356 requires DoD and other Government agencies to prepare consolidated financial statements for FY 1996 and each succeeding year...

  17. Sharing Year 2000 Testing Information on DOD Information Technology Systems

    National Research Council Canada - National Science Library

    1998-01-01

    The audit objective was to determine whether planning for year 2000 testing is adequate to ensure that mission critical DoD information technology systems will continue to operate properly after the year 2000...

  18. Department of Defense (DOD) Military Casualty/Wounded Warrior

    Data.gov (United States)

    Social Security Administration — SSA initiated this agreement with the Department of Defense (DOD) to transmit to SSA information that will identify military personnel injured or taken ill while in...

  19. DoD Global Information Grid Mission Assurance

    National Research Council Canada - National Science Library

    Bargar, Anthony

    2008-01-01

    ... for espionage and the criminal theft of data. GIG mission assurance works to ensure the DoD is able to accomplish its critical missions when networks, services, or information are unavailable, degraded, or distrusted...

  20. Logistics: DoD International Personal Property Shipment Rates

    National Research Council Canada - National Science Library

    2002-01-01

    ... all or most of the cargo space available on U.S.-flag vessels and subsequently resold the space at an inflated price to selected freight forwarders that participated in the DoD International Personal Property Program...

  1. DoD Workshop on Southeast Regional Planning and Sustainability

    National Research Council Canada - National Science Library

    Berke, Philip; Brown, Robert; Elliott, Michael; Friday, Paul; Holst, Robert; Weiss, Jonathan; Wilkens, R. N

    2007-01-01

    These proceedings encompass outcomes from the DoD Southeast Regional Planning and Sustainability Workshop, which took place in April 2007, and reflect the opinions and views of workshop participants...

  2. Proposed DoD Guidelines for Implementation of a Web-Based Joint IETM Architecture (JIA) to Assure the Interoperability of DoD IETMs

    National Research Council Canada - National Science Library

    Jorgensen, Eric L

    1999-01-01

    This Paper presents preliminary guidelines intended to serve as input to a planned DoD Handbook for the Acquisition and Deployment of DoD IETMs with the specific purpose of assuring interoperability...

  3. 77 FR 76938 - Defense Federal Acquisition Regulation Supplement: Contracting Activity Updates (DFARS Case 2012...

    Science.gov (United States)

    2012-12-31

    ... Security Cooperation Agency, the Defense Security Service, the Defense Threat Reduction Agency, the Missile... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 202 RIN 0750-AH81 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is...

  4. 76 FR 75875 - Defense Federal Acquisition Regulation Supplement; Open Source Software Public Meeting

    Science.gov (United States)

    2011-12-05

    ... Regulation Supplement; Open Source Software Public Meeting AGENCY: Defense Acquisition Regulations System... initiate a dialogue with industry regarding the use of open source software in DoD contracts. DATES: Public... to the risks to the contractors and the Government associated with using open source software on DoD...

  5. B2B Models for DoD Acquisition

    Science.gov (United States)

    2007-07-30

    product design, demand forecasting, asset management, and sales and marketing plans 35 Proctor & Gamble’s Private Industrial Network SOURCE: Laudon... B2B Models for DoD Acquisition 30 July 2007 by Magdi N. Kamel, Associate Professor Graduate School of Operational & Information Sciences...number. 1. REPORT DATE 30 JUL 2007 2. REPORT TYPE 3. DATES COVERED 00-00-2007 to 00-00-2007 4. TITLE AND SUBTITLE B2B Models for DoD

  6. Addressing Counterfeit Parts in the DoD Supply Chain

    Science.gov (United States)

    2014-03-01

    property rights to that part. Franchised distributor Distributor with which OCM has a contractual agreement to buy , stock, repackage, sell, and...because the DoD is not the largest buyer of microelectronics, the private sector market must buy into DNA tagging in order for manufacturers to include...tacitly acknowledged that “it is impossible to eliminate all risk of counterfeit in every system that the DoD buys or supports” (p. 3). Thus, Metzger

  7. Is DOD on the Right Path to Financial Auditability?

    Science.gov (United States)

    2012-03-22

    and DOD decision-making. Moreover, most of the 10 ERPs run the same software applications (i.e. SAP [Systems Applications and Programs] or PeopleSoft...Financial Readiness; GFEBS; DEAMS; Navy ERP 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF...Navy ERP CLASSIFICATION: Unclassified To make every dollar count, the Department of Defense (DOD) must be able to account for every dollar

  8. Fundamental principles of earthquake resistance calculation to be reflected in the next generation regulations

    OpenAIRE

    Mkrtychev Oleg; Dzhinchvelashvili Guram

    2016-01-01

    The article scrutinizes the pressing issues of regulation in the domain of seismic construction. The existing code of rules SNIP II-7-81* “Construction in seismic areas” provides that earthquake resistance calculation be performed on two levels of impact: basic safety earthquake (BSE) and maximum considered earthquake (MCE). However, the very nature of such calculation cannot be deemed well-founded and contradicts the fundamental standards of foreign countries. The authors of the article have...

  9. ‘Standard’ incentive regulation hinders the integration of renewable energy generation

    NARCIS (Netherlands)

    Nykamp, Stefan; Andor, Mark; Hurink, Johann L.

    The connection and distribution of growing, decentralized electricity generation from renewable energy sources (RES-E) is leading tomassive investment needs. Besides investing in additional ‘conventional’ assets (e.g. cables), grid operators can also invest in innovative ‘smart solutions’ like local

  10. Generating Keywords Improves Metacomprehension and Self-Regulation in Elementary and Middle School Children

    Science.gov (United States)

    de Bruin, Anique B. H.; Thiede, Keith W.; Camp, Gino; Redford, Joshua

    2011-01-01

    The ability to monitor understanding of texts, usually referred to as metacomprehension accuracy, is typically quite poor in adult learners; however, recently interventions have been developed to improve accuracy. In two experiments, we evaluated whether generating delayed keywords prior to judging comprehension improved metacomprehension accuracy…

  11. The nuclear safety regulation in Japan and the response to changes of circumstances surrounding the nuclear electricity generation

    International Nuclear Information System (INIS)

    Hombu, K.; Hirota, M.; Taniguchi, T.; Tanaka, N.; Akimoto, S.

    2001-01-01

    The influences of external factors on nuclear safety are discussed in this paper, based on the views on the circumstances of nuclear electricity generation. The following external factors, which might have some potential impacts on nuclear safety, are selected for discussion: (1) The deregulation in the electricity generation industry; (2) The modification of approval/certification system in the regulation of electricity generation; (3) The influences on social atmosphere due to the occurrence of a series of troubles; (4) The government reform and the structural adjustment of industry and (5) Others. Our further discussion seems to focus on the following 2 issues: (a) Whether nuclear power and the other electrical sources should compete with each other for short term economical cost, or whether factors of cost stability and competitiveness as well as longer term energy supply security and global environmental issues ranging over several decades should be considered; (b) How to realize the appropriate regulation from the perspective of public acceptance and confidence (when a series of troubles occur) without imposing unnecessary burdens on industry and without jeopardizing safety. These issues may be common among many countries and can be widely discussed. (author)

  12. The effects of question-generation training on metacognitive knowledge, self regulation and learning approaches in science.

    Science.gov (United States)

    Cano García, Francisco; García, Ángela; Berbén, A B G; Pichardo, M C; Justicia, Fernando

    2014-01-01

    Although much research has examined the impact of question generation on students' reading comprehension and learning from lectures, far less research has analysed its influence on how students learn and study science. The present study aims to bridge this knowledge gap. Using a quasi-experimental design, three complete ninth-grade science classes, with a total of 72 students, were randomly assigned to three conditions (groups): (G1) questioning-training by providing prompts; (G2) question-generation without any explicit instruction; and (G3) no question control. Participants' pre-test and post-test self-reported measures of metacognitive knowledge, self-regulation and learning approaches were collected and data analysed with multivariate and univariate analyses of covariance. (a) MANCOVA revealed a significant effect for group; (b) ANCOVAs showed the highest average gains for G1 and statistically significant between-group differences in the two components of metacognition: metacognitive knowledge and self-regulation; and (c) the direction of these differences seemed to vary in each of these components. Question-generation training influenced how students learned and studied, specifically their metacognition, and it had a medium to large effect size, which was somewhat related to the prompts used.

  13. When ideology meets conflict-related content: Influences on emotion generation and regulation.

    Science.gov (United States)

    Pliskin, Ruthie; Halperin, Eran; Bar-Tal, Daniel; Sheppes, Gal

    2018-03-01

    Do rightists and leftists experience information about suffering and harm with differing emotional intensities, depending on the identity of target depicted? Do they consequently choose differently how to regulate or cope with these emotions? Research has identified ideological differences in emotional processes, but it has yet to identify what types of content lead to ideological differences in emotional intensity or whether these content-dependent differences relate to differing preferences for engaging versus disengaging emotion-regulation strategies. We posited that right-left differences in experienced emotional intensity would be context-dependent, emerging mostly in response to depictions of harm to the outgroup, in accordance with the centrality of intergroup attitudes to ideological self-placement in conflict. Study 1 (N = 83) supported this hypothesis, with leftists (vs. rightists) experiencing outgroup harm (but not ingroup harm or conflict-irrelevant harm) with greater emotional intensity. Study 2 (N = 101), which replicated this finding, additionally examined whether behavioral differences in regulatory choice consequently emerge mostly regarding outgroup harm. We tested 2 competing hypotheses as to the nature of these differences: (a) the intensity hypothesis, positing that leftists (more than rightists) would regulate their intensified reactions to outgroup harm through disengagement-distraction (vs. engagement-reappraisal) due to a documented greater preference for disengaging coping strategies as intensity increases, and (b) the motivation hypothesis, positing that leftists (more than rightists) would prefer engagement-reappraisal (vs. disengagement-distraction), consistent with leftists' documented greater preference for intergroup empathy. Results exclusively supported the intensity hypothesis, and the significance of both studies is discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  14. Simulation of double-fed speed regulation system for 125 MVA motor-generator set

    International Nuclear Information System (INIS)

    Wang Fen; Wang Shujing; Li Huajun

    2007-01-01

    A simulation modeling of double-fed motor speed regulation for 125 MVA AC pulsed M-G set of HL-2A is built using Matlab. Some parameters of the project are obtained by the pre-simulation, and the process of start-up is analyzed. In the Matlab simulation the motor model in Simulink can not be connected directly to the cycloconverter model. This problem is solved by adding an ideal transformer model between them, and the satisfactory result is obtained. A new method of control switching two cycloconverter without circulating current has been introduced. (authors)

  15. The marginal cost of operation: a parameter for evaluating and regulating of the generation work program

    International Nuclear Information System (INIS)

    Lima, W.M.; Mendes, L.N.F.; Almeida Gattass, E. de

    1989-01-01

    The Brazilian Generator System is predominantly hydroelectric, with some reservoirs having a pluri annual regularization, providing a large storage capacity of potential power for the system. This water storage allows the reduction of the alertly effect from the natural flow over the hydraulic resources for electric power production. Due to this structural characteristic, the main operation problem of the system refers to a strategical determination of storage energy utilization and, consequently, the thermal generation level. This paper examines the theoretical concepts referring to the survey of this operation strategies and analyses the factors for improving. These concepts are also extended for the interconnected electric subsystems case, mainly the interchange effect over the operation strategies of each subsystem. Finally, the natural flow sample influence over the marginal cost is analysed, comparing the obtained values with the historical sample and synthetical series of affluence. (C.G.C.). 7 refs, 2 figs, 5 tabs

  16. Repair of steam generator heating tubes by roll-expanded plugs: approach to cover multiple national regulations

    Energy Technology Data Exchange (ETDEWEB)

    Beck, J.; Ziegler, B.; Schoenheit, N. [AREVA NP Gmbh, Erlangen (Germany); Kostroun, F. [AREVA NP Canada Ltd., Pickering, ON (Canada)

    2012-07-01

    During operation, steam generators in nuclear power plants are subject to degradation mechanisms which have an impact on the component life-time. Most affected are the heating tubes which constitute the barrier of the contaminated primary cycle to the secondary side. Various corrosive attacks may cause wall thinning which requires tube repair. A common repair method is to plug the tubes by roll expanded plugs. This is a fast method, easily applicable and requires less equipment or personnel qualification as needed for weld plugs. After insertion, the plugs act as a pressure boundary from primary to secondary side. Although the function of the roll plug is simple, the different national regulations define the requirements which need to be fulfilled by a roll plug differently. In order to reduce the tooling as well as the plug types to a minimum, an approach according to one common design for different regulations and steam generator types is profitable. It was found, that the regulations according to the ASME Boiler and Pressure Vessel code in combination with the German Safety Standards of the German Nuclear Safety Standards Commission covers the regulations of the majority of utilities. To develop a roll plug which suits the different regulatory demands, efforts were made to consider all technical and regulatory boundary conditions implied on roll expanded plugs. This covering approach had an impact on the plug design, which was required to be Helium tight after installation and suitable for a 40 year component lifetime also in accident and emergency conditions. To prove the suitability of the plug design a comprehensive testing programme of the mechanical and chemical properties of the designed roll-expanded plug was launched. A summary of the plug design and testing as well as the main test results are described. (author)

  17. Repair of steam generator heating tubes by roll-expanded plugs: approach to cover multiple national regulations

    International Nuclear Information System (INIS)

    Beck, J.; Ziegler, B.; Schoenheit, N.; Kostroun, F.

    2012-01-01

    During operation, steam generators in nuclear power plants are subject to degradation mechanisms which have an impact on the component life-time. Most affected are the heating tubes which constitute the barrier of the contaminated primary cycle to the secondary side. Various corrosive attacks may cause wall thinning which requires tube repair. A common repair method is to plug the tubes by roll expanded plugs. This is a fast method, easily applicable and requires less equipment or personnel qualification as needed for weld plugs. After insertion, the plugs act as a pressure boundary from primary to secondary side. Although the function of the roll plug is simple, the different national regulations define the requirements which need to be fulfilled by a roll plug differently. In order to reduce the tooling as well as the plug types to a minimum, an approach according to one common design for different regulations and steam generator types is profitable. It was found, that the regulations according to the ASME Boiler and Pressure Vessel code in combination with the German Safety Standards of the German Nuclear Safety Standards Commission covers the regulations of the majority of utilities. To develop a roll plug which suits the different regulatory demands, efforts were made to consider all technical and regulatory boundary conditions implied on roll expanded plugs. This covering approach had an impact on the plug design, which was required to be Helium tight after installation and suitable for a 40 year component lifetime also in accident and emergency conditions. To prove the suitability of the plug design a comprehensive testing programme of the mechanical and chemical properties of the designed roll-expanded plug was launched. A summary of the plug design and testing as well as the main test results are described. (author)

  18. Regulation for delivery of subsidies for urgent safety measures for atomic power generating facilities

    International Nuclear Information System (INIS)

    1981-01-01

    This rule is established under the provisions of the law for the proper enforcement of subsidy budgets and the ordinance for the execution of this law and to practice these provisions. It is applied to the delivery of subsidies for the expenses of the measures taken beforehand for the security of inhabitants in the surrounding areas of atomic power generating facilities in the emergency time of hazard or the danger of the occurrence of hazard by such facilities. Basic terms are defined, such as atomic power generating facilities and others, prefecture concerned, cities, towns and villages concerned, emergency communication network arrangement business, emergency medical facility arrangement business, business of holding hazard prevention course and expected date of beginning operation. Directors of ministries and agencies concerned deliver, if necessary, to prefectures concerned subsidies for all or a part of the expenses needed for the businesses of emergency communication network arrangement, emergency medical facility arrangement and holding hazard prevention course. The terms of delivery and the amounts of subsidies vary according to the kinds of businesses. Prefectures which intend to apply for the delivery of subsidies shall file to the director of the ministry or agency concerned the specified application attaching the operation plans of businesses and the general explanation of atomic power generating facilities, etc. The decision and conditions of delivery, reports on the situations and results of businesses and other related matters are defined, respectively. (Okada, K.)

  19. Financial Health Indicators: An Analysis Of Financial Statement Information To Determine The Financial Health Of DOD Contractors

    Science.gov (United States)

    2016-12-01

    examples of fraud risk factors, including the opportunity for top management to commit fraud due to ineffective monitoring of management as a result of...Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188...Officer COGS Cost of Goods Sold COSO Committee of Sponsoring Organizations DOD Department of Defense FAR Federal Acquisition Regulations GAAP

  20. Anion-Regulated Selective Generation of Cobalt Sites in Carbon: Toward Superior Bifunctional Electrocatalysis

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Gang [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road Shanghai 200050 P. R. China; University of Chinese Academy of Sciences, Beijing 100049 P. R. China; Yang, Ce [Chemical Science and Engineering Division, Argonne National Laboratory, 9700 Cass Avenue Lemont IL 60439 USA; Zhao, Wanpeng [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road Shanghai 200050 P. R. China; University of Chinese Academy of Sciences, Beijing 100049 P. R. China; Li, Qianru [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road Shanghai 200050 P. R. China; University of Chinese Academy of Sciences, Beijing 100049 P. R. China; Wang, Ning [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road Shanghai 200050 P. R. China; University of Chinese Academy of Sciences, Beijing 100049 P. R. China; Li, Tao [X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, 9700 Cass Avenue Lemont IL 60439 USA; Zhou, Hua [X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, 9700 Cass Avenue Lemont IL 60439 USA; Chen, Hangrong [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road Shanghai 200050 P. R. China; Shi, Jianlin [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road Shanghai 200050 P. R. China

    2017-11-06

    The introduction of active transition metal sites (TMSs) in carbon enables the synthesis of noble-metal-free electrocatalysts for clean energy conversion applications, however, there are often multiple existing forms of TMSs, which are of different natures and catalytic models. Regulating the evolution of distinctive TMSs is highly desirable but remains challenging to date. Anions, as essential elements involved in the synthesis, have been totally neglected previously in the construction of TMSs. Herein, the effects of anions on the creation of different types of TMSs is investigated for the first time. It is found that the active cobalt-nitrogen sites tend to be selectively constructed on the surface of N-doped carbon by using chloride, while metallic cobalt nanoparticles encased in protective graphite layers are the dominant forms of cobalt species with nitrate ions. The obtained catalysts demonstrate cobalt-sites-dependent activity for ORR and HER in acidic media. And the remarkably enhanced catalytic activities approaching that of benchmark Pt/C in acidic medium has been obtained on the catalyst dominated with cobalt-nitrogen sites, confirmed by the advanced spectroscopic . Our finding demonstrates a general paradigm of anion-regulated evolution of distinctive TMSs, providing a new pathway for enhancing performances of various targeted reactions related with TMSs.

  1. Toward Integrated DoD Biosurveillance: Assessment and Opportunities.

    Science.gov (United States)

    Moore, Melinda; Fisher, Gail; Stevens, Clare

    2014-01-01

    In the context of the 2012 National Strategy for Biosurveillance, the Office of Management and Budget (OMB) asked the Department of Defense (DoD) to review its biosurveillance programs, prioritize missions and desired outcomes, evaluate how DoD programs contribute to these, and assess the appropriateness and stability of the department's funding system for biosurveillance. DoD sought external analytic support through the RAND Arroyo Center. In response to the questions posed by OMB request, this study finds the following: (1) Current DoD biosurveillance supports three strategic missions. Based mostly on existing statute, the highest-priority mission is force health protection, followed by biological weapons defense and global health security. (2) Guidance issued by the White House on June 27, 2013, specified priorities for planning fiscal year 2015 budgets; it includes an explicit global health security priority, which strengthens the case for this as a key DoD biosurveillance strategic mission. (3) DoD biosurveillance also supports four desired outcomes: early warning and early detection, situational awareness, better decision making at all levels, and forecast of impacts. (4) Programs and measures that address priority missions-force health protection in particular-and desired outcomes should be prioritized over those that do not do so. (5) More near-real-time analysis and better internal and external integration could enhance the performance and value of the biosurveillance enterprise. (6) Improvements are needed in key enablers, including explicit doctrine/policy, efficient organization and governance, and increased staffing and improved facilities for the Armed Forces Health Surveillance Center (AFHSC). (7) AFHSC has requested additional funding to fully implement its current responsibilities under the 2012 Memorandum of Understanding between the Assistant Secretaries of Defense for Health Affairs and for Nuclear, Chemical, and Biological Defense Programs

  2. 78 FR 31551 - Federal Acquisition Regulation; Submission for OMB Review; Commerce Patent Regulations

    Science.gov (United States)

    2013-05-24

    ...; Submission for OMB Review; Commerce Patent Regulations AGENCIES: Department of Defense (DOD), General... collection requirement concerning Department of Commerce patent regulations. A notice was published in...- 0095, Commerce Patent Regulations, by any of the following methods: Regulations.gov : http://www...

  3. Application of Thermoelectric Devices to Fuel Cell Power Generation: Demonstration and Evaluation

    National Research Council Canada - National Science Library

    Huston, John; Wyatt, Chris; Nichols, Chris; Binder, Michael J; Holcomb, Franklin H

    2004-01-01

    The Department of Defense (DOD) is concerned with reliable and cost-effective power generation of on-site power generators as well as minimizing the environment impact of these generators. Thermoelectric (TE...

  4. Study of the modification of the regulation of the Cadarache Van de Graaff generator

    International Nuclear Information System (INIS)

    Le Bot, M.; Rion, J.

    1968-09-01

    The complete renewal of the energy control equipment of the Van de Graaff generator at Cadarache has been accompanied by a certain number of modifications intended to improve the running and operation of the assembly. The most important work has been the addition of an extra control loop making it possible to keep the voltage on the accelerating tube in the absence of a beam. Analog simulation has made it possible to show the advantages of this solution and the effect of some of its limits. (authors) [fr

  5. The supernova-regulated ISM. III. Generation of vorticity, helicity, and mean flows

    Science.gov (United States)

    Käpylä, M. J.; Gent, F. A.; Väisälä, M. S.; Sarson, G. R.

    2018-03-01

    Context. The forcing of interstellar turbulence, driven mainly by supernova (SN) explosions, is irrotational in nature, but the development of significant amounts of vorticity and helicity, accompanied by large-scale dynamo action, has been reported. Aim. Several earlier investigations examined vorticity production in simpler systems; here all the relevant processes can be considered simultaneously. We also investigate the mechanisms for the generation of net helicity and large-scale flow in the system. Methods: We use a three-dimensional, stratified, rotating and shearing local simulation domain of the size 1 × 1 × 2 kpc3, forced with SN explosions occurring at a rate typical of the solar neighbourhood in the Milky Way. In addition to the nominal simulation run with realistic Milky Way parameters, we vary the rotation and shear rates, but keep the absolute value of their ratio fixed. Reversing the sign of shear vs. rotation allows us to separate the rotation- and shear-generated contributions. Results: As in earlier studies, we find the generation of significant amounts of vorticity, the rotational flow comprising on average 65% of the total flow. The vorticity production can be related to the baroclinicity of the flow, especially in the regions of hot, dilute clustered supernova bubbles. In these regions, the vortex stretching acts as a sink of vorticity. In denser, compressed regions, the vortex stretching amplifies vorticity, but remains sub-dominant to baroclinicity. The net helicities produced by rotation and shear are of opposite signs for physically motivated rotation laws, with the solar neighbourhood parameters resulting in the near cancellation of the total net helicity. We also find the excitation of oscillatory mean flows, the strength and oscillation period of which depend on the Coriolis and shear parameters; we interpret these as signatures of the anisotropic-kinetic-α (AKA) effect. We use the method of moments to fit for the turbulent transport

  6. Contribution of VSC-HVDC to Frequency Regulation of Power Systems With Offshore Wind Generation

    DEFF Research Database (Denmark)

    Liu, Hongzhi; Chen, Zhe

    2015-01-01

    to the onshore system grid through voltage-source converter-based–high voltage direct current (VSC-HVdc) transmission systems. Due to the decoupling of VSC-HVdc and signal transmission delay, offshore wind farms may not be able to respond to the onshore grid frequency excursion in time and, consequently......, the stability and security of the power system will be put at risk, especially for those with high wind penetration. This paper proposes a coordinated control scheme to allow VSC-HVdc link to contribute to the system frequency regulation by adjusting its dc-link voltage. By means of this approach, the dc...... capacitors of VSC-HVdc are controlled to absorb or release energy so as to provide frequency support. To further enhance the system frequency response, the frequency support from VSC-HVdc is also finely coordinated with that from offshore wind farm according to the latency of offshore wind farm responding...

  7. Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators

    Directory of Open Access Journals (Sweden)

    G. Musso

    2015-12-01

    Full Text Available The vertebrate heart develops from two distinct lineages of cardiomyocytes that arise from the first and second heart fields (FHF and SHF, respectively. The FHF forms the primitive heart tube, while adding cells from the SHF allows elongation at both poles of the tube. Initially seen as an exclusive characteristic of higher vertebrates, recent work has demonstrated the presence of a distinct FHF and SHF in lower vertebrates, including zebrafish. We found that key transcription factors that regulate septation and chamber formation in higher vertebrates, including Tbx5 and Pitx2, influence relative FHF and SHF contributions to the zebrafish heart tube. To identify molecular modulators of heart field migration, we used microarray-based expression profiling following inhibition of tbx5a and pitx2ab in embryonic zebrafish (Mosimann & Panakova, et al, 2015; GSE70750. Here, we describe in more detail the procedure used to process, prioritize, and analyze the expression data for functional enrichment.

  8. Fundamental principles of earthquake resistance calculation to be reflected in the next generation regulations

    Directory of Open Access Journals (Sweden)

    Mkrtychev Oleg

    2016-01-01

    Full Text Available The article scrutinizes the pressing issues of regulation in the domain of seismic construction. The existing code of rules SNIP II-7-81* “Construction in seismic areas” provides that earthquake resistance calculation be performed on two levels of impact: basic safety earthquake (BSE and maximum considered earthquake (MCE. However, the very nature of such calculation cannot be deemed well-founded and contradicts the fundamental standards of foreign countries. The authors of the article have identified the main problems of the conceptual foundation underlying the current regulation. The first and foremost step intended to overcome the discrepancy in question is renunciation of the K1 damage tolerance factor when calculating the BSE. The second measure to be taken is implementing the response spectrum method of calculation, but the β spectral curve of the dynamic response factor must be replaced by a spectrum of worst-case accelerograms for this particular structure or a spectrum of simulated accelerograms obtained for the specific construction site. Application of the response spectrum method when calculating the MCE impact level makes it possible to proceed into the frequency domain and to eventually obtain spectra of the accelerograms. As a result we get to know the response of the building to some extent, i.e. forces, the required reinforcement, and it can be checked whether the conditions of the ultimate limit state apply. Then, the elements under the most intense load are excluded from the design model the way it is done in case of progressive collapse calculations, because the assumption is that these elements are destroyed locally by seismic load. This procedure is based on the already existing design practices of progressive collapse calculation.

  9. Platelet-derived microparticles regulates thrombin generation via phophatidylserine in abdominal sepsis.

    Science.gov (United States)

    Wang, Yongzhi; Zhang, Su; Luo, Lingtao; Norström, Eva; Braun, Oscar Ö; Mörgelin, Matthias; Thorlacius, Henrik

    2018-02-01

    Sepsis is associated with dysfunctional coagulation. Recent data suggest that platelets play a role in sepsis by promoting neutrophil accumulation. Herein, we show that cecal ligation and puncture (CLP) triggered systemic inflammation, which is characterized by formation of IL-6 and CXC chemokines as well as neutrophil accumulation in the lung. Platelet depletion decreased neutrophil accumulation, IL-6, and CXC chemokines formation in septic lungs. Depletion of platelets increased peak thrombin formation and total thrombin generation (TG) in plasma from septic animals. CLP elevated circulating levels of platelet-derived microparticles (PMPs). In vitro generated PMPs were a potent inducer of TG. Interestingly, in vitro wild-type recombinant annexin V abolished PMP-induced thrombin formation whereas a mutant annexin V protein, which does not bind to phosphatidylserine (PS), had no effect. Administration of wild-type, but not mutant annexin V, significantly inhibited thrombin formation in septic animals. Moreover, CLP-induced formation of thrombin-antithrombin complexes were reduced in platelet-depleted mice and in animals pretreated with annexin V. PMP-induced TG attenuated in FXII- and FVII-deficient plasma. These findings suggest that sepsis-induced TG is dependent on platelets. Moreover, PMPs formed in sepsis are a potent inducer of TG via PS exposure, and activation of both the intrinsic and extrinsic pathway of coagulation. In conclusion, these observations suggest that PMPs and PS play an important role in dysfunctional coagulation in abdominal sepsis. © 2017 Wiley Periodicals, Inc.

  10. Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.

    Science.gov (United States)

    Fame, Ryann M; MacDonald, Jessica L; Dunwoodie, Sally L; Takahashi, Emi; Macklis, Jeffrey D

    2016-06-15

    The neocortex contains hundreds to thousands of distinct subtypes of precisely connected neurons, allowing it to perform remarkably complex tasks of high-level cognition. Callosal projection neurons (CPN) connect the cerebral hemispheres via the corpus callosum, integrating cortical information and playing key roles in associative cognition. CPN are a strikingly diverse set of neuronal subpopulations, and development of this diversity requires precise control by a complex, interactive set of molecular effectors. We have found that the transcriptional coregulator Cited2 regulates and refines two stages of CPN development. Cited2 is expressed broadly by progenitors in the embryonic day 15.5 subventricular zone, during the peak of superficial layer CPN birth, with a progressive postmitotic refinement in expression, becoming restricted to CPN of the somatosensory cortex postnatally. We generated progenitor-stage and postmitotic forebrain-specific Cited2 conditional knock-out mice, using the Emx1-Cre and NEX-Cre mouse lines, respectively. We demonstrate that Cited2 functions in progenitors, but is not necessary postmitotically, to regulate both (1) broad generation of layer II/III CPN and (2) acquisition of precise area-specific molecular identity and axonal/dendritic connectivity of somatosensory CPN. This novel CPN subtype-specific and area-specific control from progenitor action of Cited2 adds yet another layer of complexity to the multistage developmental regulation of neocortical development. This study identifies Cited2 as a novel subtype-specific and area-specific control over development of distinct subpopulations within the broad population of callosal projection neurons (CPN), whose axons connect the two cerebral hemispheres via the corpus callosum (CC). Currently, how the remarkable diversity of CPN subtypes is specified, and how they differentiate to form highly precise and specific circuits, are largely unknown. We found that Cited2 functions within

  11. Persona Rights for User-Generated Content: A Normative Framework for Privacy and Intellectual Property Regulation

    Directory of Open Access Journals (Sweden)

    Tamara Shepherd

    2012-02-01

    Full Text Available This article introduces the term “persona rights” as a normative conceptual framework for analyzing the language of regulatory debates around privacy and intellectual property online, mainly from a Canadian perspective. In using the concept of persona rights to interrogate and critique the current limitations of regulatory discourses in protecting user rights online, the legal implications of persona rights law are translated into more conceptual terms. As a normative framework, persona rights is shown to be useful in addressing the gaps in regulatory understandings of privacy and intellectual property – particularly in spaces for user-generated content (UGC – and in suggesting how policy might be written to account for user rights to the integrity of identity in commercial UGC platforms.

  12. Experience in connecting the power generating units of thermal power plants to automatic secondary frequency regulation within the united power system of Russia

    International Nuclear Information System (INIS)

    Zhukov, A. V.; Komarov, A. N.; Safronov, A. N.; Barsukov, I. V.

    2009-01-01

    The principles of central control of the power generating units of thermal power plants by automatic secondary frequency and active power overcurrent regulation systems, and the algorithms for interactions between automatic power control systems for the power production units in thermal power plants and centralized systems for automatic frequency and power regulation, are discussed. The order of switching the power generating units of thermal power plants over to control by a centralized system for automatic frequency and power regulation and by the Central Coordinating System for automatic frequency and power regulation is presented. The results of full-scale system tests of the control of power generating units of the Kirishskaya, Stavropol, and Perm GRES (State Regional Electric Power Plants) by the Central Coordinating System for automatic frequency and power regulation at the United Power System of Russia on September 23-25, 2008, are reported.

  13. Activation of the Small GTPase Rap1 Inhibits Choroidal Neovascularization by Regulating Cell Junctions and ROS Generation in Rats.

    Science.gov (United States)

    Li, Jiajia; Zhang, Rong; Wang, Caixia; Wang, Xin; Xu, Man; Ma, Jingxue; Shang, Qingli

    2018-03-30

    Choroidal neovascularization (CNV) is a common vision-threatening complication associated with many  fundus diseases. The retinal pigment epithelial (RPE) cell junction barrier has critical functions in preventing CNV, and oxidative stress can cause compromise of barrier integrity and induce angiogenesis. Rap1, a small guanosine triphosphatase (GTPase), is involved in regulating endothelial and epithelial cell junctions. In this work, we explored the function and mechanism of Rap1 in CNV in vivo. A laser-induced rat CNV model was developed. Rap1 was activated through intravitreal injection of the Rap1 activator 8CPT-2'-O-Me-cAMP (8CPT). At 14 days after laser treatment, CNV size in RPE/choroid flat mounts was measured by fluorescein isothiocyanate-dextran staining. Expression of vascular endothelial growth factor (VEGF) and cell junction proteins in RPE/choroid tissues were analyzed by western blots and quantitative real-time PCR assays. Reactive oxygen species (ROS) in RPE cells were detectedbydichloro-dihydro-fluorescein diacetate assays. The antioxidant apocynin was intraperitoneally injected into rats. Activating Rap1 by 8CPT significantly reduced CNV size and VEGF expression in the rat CNV model. Rap1 activation enhanced protein and mRNA levels of ZO-1 and occludin, two tight junction proteins in the RPE barrier. In addition, reducing ROS generation by injection of apocynin, a NADPH oxidase inhibitor, inhibited CNV formation. Rap1 activation reduced ROS generation and expression of NADPH oxidase 4. Rap1 activation inhibits CNV through regulating barrier integrity and ROS generation of RPE in vivo, and selectively activating Rap1 may be a way to reduce vision loss from CNV.

  14. Access regulation in the next generation access network environment: A comparative study of Hong Kong and Singapore from the transaction cost economics perspectives

    OpenAIRE

    Ho, Au Man

    2012-01-01

    Hong Kong and Singapore have adopted two different models in the regulation of the next generation access (NGA) networks. In Hong Kong, the government has decided that access regulation will not be applied to fibre-based access networks and its strategy will be to rely on facilities-based competition to promote investment in the NGA networks. Singapore, on the other hand, has promoted access/services-based competition over a next generation broadband infrastructure subsidised by public fundin...

  15. Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation.

    Science.gov (United States)

    Dapunt, Ulrike; Giese, Thomas; Maurer, Susanne; Stegmaier, Sabine; Prior, Birgit; Hänsch, G Maria; Gaida, Matthias M

    2015-10-01

    Bone infections of patients with joint replacement by endoprosthesis (so called "periprosthetic joint infection") pose a severe problem in the field of orthopedic surgery. The diagnosis is often difficult, and treatment is, in most cases, complicated and prolonged. Patients often require an implant exchange surgery, as the persistent infection and the accompanying inflammation lead to tissue damage with bone degradation and consequently, to a loosening of the implant. To gain insight into the local inflammatory process, expression of the proinflammatory cytokine MRP-14, a major content of neutrophils, and its link to subsequent bone degradation was evaluated. We found MRP-14 prominently expressed in the affected tissue of patients with implant-associated infection, in close association with the chemokine CXCL8 and a dense infiltrate of neutrophils and macrophages. In addition, the number of MRP-14-positive cells correlated with the presence of bone-resorbing osteoclasts. MRP-14 plasma concentrations were significantly higher in patients with implant-associated infection compared with patients with sterile inflammation or healthy individuals, advocating MRP-14 as a novel diagnostic marker. A further biologic activity of MRP-14 was detected: rMRP-14 directly induced the differentiation of monocytes to osteoclasts, thus linking the inflammatory response in implant infections with osteoclast generation, bone degradation, and implant loosening. © Society for Leukocyte Biology.

  16. Inorganic Polyphosphates Regulate Hexokinase Activity and Reactive Oxygen Species Generation in Mitochondria of Rhipicephalus (Boophilus) microplus Embryo

    Science.gov (United States)

    Fraga, Amanda; Moraes, Jorge; da Silva, José Roberto; Costa, Evenilton P.; Menezes, Jackson; da Silva Vaz Jr, Itabajara; Logullo, Carlos; da Fonseca, Rodrigo Nunes; Campos, Eldo

    2013-01-01

    The physiological roles of polyphosphates (poly P) recently found in arthropod mitochondria remain obscure. Here, the possible involvement of poly P with reactive oxygen species generation in mitochondria of Rhipicephalus microplus embryos was investigated. Mitochondrial hexokinase and scavenger antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione reductase were assayed during embryogenesis of R. microplus. The influence of poly P3 and poly P15 were analyzed during the period of higher enzymatic activity during embryogenesis. Both poly Ps inhibited hexokinase activity by up to 90% and, interestingly, the mitochondrial membrane exopolyphosphatase activity was stimulated by the hexokinase reaction product, glucose-6-phosphate. Poly P increased hydrogen peroxide generation in mitochondria in a situation where mitochondrial hexokinase is also active. The superoxide dismutase, catalase and glutathione reductase activities were higher during embryo cellularization, at the end of embryogenesis and during embryo segmentation, respectively. All of the enzymes were stimulated by poly P3. However, superoxide dismutase was not affected by poly P15, catalase activity was stimulated only at high concentrations and glutathione reductase was the only enzyme that was stimulated in the same way by both poly Ps. Altogether, our results indicate that inorganic polyphosphate and mitochondrial membrane exopolyphosphatase regulation can be correlated with the generation of reactive oxygen species in the mitochondria of R. microplus embryos. PMID:23983617

  17. 76 FR 7522 - Federal Acquisition Regulation; Enhancing Contract Transparency

    Science.gov (United States)

    2011-02-10

    ... transparency while retaining the protection of information that should be considered in the contracting process... the need for transparency in Government contracting information and believe these recommendations... Regulation; Enhancing Contract Transparency AGENCY: Department of Defense (DoD), General Services...

  18. 76 FR 37704 - Federal Acquisition Regulation; Documenting Contractor Performance

    Science.gov (United States)

    2011-06-28

    ... Federal Acquisition Regulation; Documenting Contractor Performance AGENCY: Department of Defense (DoD..., and to require all past performance information be entered into the Contractor Performance Assessment... Contractor Performance Information. These changes provide Governmentwide standardized evaluation factors and...

  19. The influence of age-related health difficulties and attitudes toward driving on driving self-regulation in the baby boomer and older adult generations.

    Science.gov (United States)

    Conlon, Elizabeth G; Rahaley, Nicole; Davis, Jessica

    2017-05-01

    Our study aimed to determine how age- and disease-related difficulties were associated with attitudes and beliefs about driving self-regulation in men and women in the baby boomer and older generations. Three hundred and ninety-nine men (n=204) and women (n=195) aged between 48 and 91 years participated in a cross-sectional study of Australian drivers. Demographic characteristics and measures of driving confidence, driving difficulty and driving self-regulation; perceptions of visual, physical and cognitive capacity; and attitudes and beliefs about driving were obtained. Driving self-regulation in men and women was explained by different mechanisms. For men, self-report of visual and cognitive difficulties and poor driving confidence predicted driving self-regulation. For women, negative attitudes toward driving mediated the associations found between health-related difficulties and driving self-regulation. Barriers to driving self-regulation were not associated with the driving self-regulatory practices of men or women. Regardless of generation, women reported poorer driving confidence, greater driving difficulty and more driving self-regulation than men. We concluded that age- and disease-related difficulties are related to increasing driving self-regulation in mature men and women. These results indicate that different pathways are needed in models of driving self-regulation for men and women regardless of generational cohort. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Separate DOD and DOA Estimation for Bistatic MIMO Radar

    Directory of Open Access Journals (Sweden)

    Lin Li

    2016-01-01

    Full Text Available A novel MUSIC-type algorithm is derived in this paper for the direction of departure (DOD and direction of arrival (DOA estimation in a bistatic MIMO radar. Through rearranging the received signal matrix, we illustrate that the DOD and the DOA can be separately estimated. Compared with conventional MUSIC-type algorithms, the proposed separate MUSIC algorithm can avoid the interference between DOD and DOA estimations effectively. Therefore, it is expected to give a better angle estimation performance and have a much lower computational complexity. Meanwhile, we demonstrate that our method is also effective for coherent targets in MIMO radar. Simulation results verify the efficiency of the proposed method, particularly when the signal-to-noise ratio (SNR is low and/or the number of snapshots is small.

  1. Military Training: Management Actions Needed to Enhance DOD's Investment in the Joint National Training Capability

    National Research Council Canada - National Science Library

    St. Laurent, Janet; Durland, Laura; Harrison, Fred; Faley, Joe; Anderson, Bonita; Watson, Angela; Song, Yong; Keith, Kevin; Ditto, Susan; Shea, Rebecca

    2006-01-01

    .... While DOD's initial training transformation assessment set a basic framework for measuring future program performance, DOD has not developed a strategy to evaluate the overall impact of the JNTC...

  2. Logistics: Use of DoD Resources Supporting Hurricane Katrina Disaster

    National Research Council Canada - National Science Library

    Scott, Wanda A; Bloomer, Donald A; Owens, Keith M; Bryant, Leon D; Matthews, Takia A; Chavez, Bryan M; Torres, Anthony M; Woolard, Alan J; Pugh, Jacqueline N

    2006-01-01

    We performed the audit in response to a September 2005 request by the Principal Deputy Inspector General, DoD to assess the use of DoD resources in providing relief efforts in support of the Hurricane...

  3. Military Transformation: Progress and Challenges for DOD's Advanced Distributed Learning Programs

    National Research Council Canada - National Science Library

    Ensign, John

    2003-01-01

    The Department of Defense (DOD) spends more than $17 billion annually for military schools that offer nearly 30,000 military training courses to almost 3 million military personnel and DOD civilians, much of it to maintain readiness...

  4. Major Deficiencies Preventing Auditors From Rendering Audit Opinions on DOD General Fund Financial Statements

    National Research Council Canada - National Science Library

    Rauu, Russell

    1995-01-01

    .... This report gives Congress, the Secretary of Defense, the DoD Chief Financial Officer, financial managers, and the audit community an assessment of progress made in audited financial statements of DoD general funds...

  5. Managing Sensitive Information: DOD Can More Effectively Reduce the Risk of Classification Errors

    National Research Council Canada - National Science Library

    D'Agostino, Davi M; Borseth, Ann; Fenton, Mattias; Hatton, Adam; Hills, Barbara; Keefer, David; Mayfield, David; Reid, Jim; Richardson, Terry; Schwartz, Marc

    2006-01-01

    ...) information security program are increasing the risk of misclassification. DoD's information security program is decentralized to the DoD component level, and the Office of the Under Secretary of Defense for Intelligence (OUSD...

  6. Gulf War Illnesses: DOD's Conclusions about U.S. Troops' Exposure Cannot Be Adequately Supported

    National Research Council Canada - National Science Library

    Rhodes, Keith

    2004-01-01

    ... (MOD) conclusions about troops' exposure. The GAO found that DoD's and MOD's conclusions about troops' exposure to CW agents, based on DoD and CIA plume modeling, cannot be adequately supported...

  7. BIA and DOD Schools: Student Achievement and Other Characteristics Often Differ from Public Schools

    National Research Council Canada - National Science Library

    2001-01-01

    ...) and the Department of Defense (DOD) school systems. Unlike public schools, where federal funding constitutes a small portion of total resources, the BIA and DOD school systems depend almost entirely on federal funds...

  8. BIA AND DOD SCHOOLS: Student Achievement and Other Characteristics Often Differ from Public Schools

    National Research Council Canada - National Science Library

    2001-01-01

    ...) and the Department of Defense (DOD) school systems. Unlike public schools, where federal funding constitutes a small portion of total resources, the BIA and DOD school systems depend almost entirely on federal funds...

  9. Defense Infrastructure: DoD Environmental Community Involvement Programs at Test and Training Ranges

    National Research Council Canada - National Science Library

    2002-01-01

    Who Should Read This Report and Why? This report should be of interest to operational personnel at DoD test and training ranges and to others concerned with the sustainability of DoD test and training ranges...

  10. Financial Management: DoD Process for Reporting Contingent Legal Liabilities

    National Research Council Canada - National Science Library

    Granetto, Paul J; Marsh, Patricia A; Peek, Marvin L; Brittingham, Scott S; Baidridge, Denise E; Egu, Charles O; Schenck, Kristy M; Adams, Carl L; Reiser, Cheri L

    2006-01-01

    .... The report is intended to convey systemic concerns across DoD and to provide DoD management and legal counsel the basis for developing policies and procedures for reporting and disclosing contingent...

  11. Inspector General, DOD, Oversight of the Audit of the FY 2000 Military Retirement Fund Financial Statements

    National Research Council Canada - National Science Library

    Lane, F

    2001-01-01

    .... This Bulletin requires the Inspector General, DoD, or an independent auditor, to express an opinion on the DoD financial statements and to report on the adequacy of internal controls and compliance...

  12. Planning for Diversity: Options and Recommendations for DoD Leaders

    National Research Council Canada - National Science Library

    Lim, Nelson; Cho, Michelle; Curry, Kimberly

    2008-01-01

    With this report, the authors aim to assist Department of Defense (DoD) leaders in their effort to develop a strategic plan to achieve greater diversity among DoD active duty and civilian leadership...

  13. The regulation for delivery of subsidies for measures of promoting power source location for nuclear power generating facilities

    International Nuclear Information System (INIS)

    1984-01-01

    According to the law for the arrangement of surrounding areas of power generating facilities, the regulations concern the allocation of subsidies to promote the most efficient way of siting nuclear power facilities. The contents consist of the following: limits on the subsidies, terms of subsidy allocations, the sum of subsidies for each respective year, applications for subsidies, determination of subsidy allocations, withdrawal of applications, the conditions attached to the allocations, a report on the work proceedings, a report on the results, confirmation on the sum of the subsidies, withdrawal of the decision for subsidies, limitations for disposal of the properties, payment of subsidies, accounting of the subsidy operations, a record of the subsidies, and the chief in the governmental office concerned. (Mori, K.)

  14. Elections: DOD Needs More Comprehensive Planning to Address Military and Overseas Absentee Voting Challenges

    Science.gov (United States)

    2016-04-01

    Acknowledgments Contact Acknowledgments Related GAO Products Page 75 GAO-16-378 DOD Overseas Absentee Voting U.S. Postal Service: Actions... Products Page 76 GAO-16-378 DOD Overseas Absentee Voting Election Reform: Nine States’ Experiences Implementing Federal Requirements for...ELECTIONS DOD Needs More Comprehensive Planning to Address Military and Overseas Absentee Voting Challenges

  15. Chief Information Officer > About DoD CIO > Organization > DCIO R&A

    Science.gov (United States)

    of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE , where she helps the organization serve as the DoD CIO focal point for the PPB&E process, including includes personnel management and congressional support. This organization underpins all of DoD CIO's

  16. Whistleblower Protection: DOD Needs to Enhance Oversight of Military Whistleblower Reprisal Investigations

    Science.gov (United States)

    2015-05-01

    WHISTLEBLOWER PROTECTION DOD Needs to Enhance Oversight of Military Whistleblower Reprisal Investigations Report...00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Whistleblower Protection: DOD Needs to Enhance Oversight of Military Whistleblower Reprisal...Government Accountability Office Highlights of GAO-15-477, a report to congressional requesters May 2015 WHISTLEBLOWER PROTECTION DOD

  17. DOD Financial Management: Significant Efforts Still Needed for Remediating Audit Readiness Deficiencies

    Science.gov (United States)

    2017-02-01

    DOD FINANCIAL MANAGEMENT Significant Efforts Still Needed for Remediating Audit Readiness Deficiencies Report to...Accountability Office Highlights of GAO-17-85, a report to congressional committees February 2017 DOD FINANCIAL MANAGEMENT Significant Efforts Still...actions to address the IPAs’ recommendations. Office of Management and Budget (OMB) guidance and the Department of Defense’s (DOD) Financial

  18. 78 FR 9890 - DoD Board of Actuaries; Notice of Federal Advisory Committee Meeting

    Science.gov (United States)

    2013-02-12

    ... DEPARTMENT OF DEFENSE Office of the Secretary DoD Board of Actuaries; Notice of Federal Advisory... Advisory Committee meeting of the DoD Board of Actuaries will take place. DATES: July 18, 2013, from 1:00 p... Defense Human Resource Activity, DoD Office of the Actuary, 4800 Mark Center Drive, STE 06J25-01...

  19. Community Relations: DOD’s Approach for Using Resources Reflects Sound Management Principles

    Science.gov (United States)

    2016-09-01

    COMMUNITY RELATIONS DOD’s Approach for Using Resources Reflects Sound Management Principles Report to...Sound Management Principles What GAO Found The Department of Defense’s (DOD) approach for determining which community relations activities to...undertake reflects sound management principles —both for activities requested by non-DOD entities and for activities initiated by the department. DOD and

  20. A Study to Develop the Optimal Military Inter-Institutional Patient Referral Systems Model for DoD (Department of Defense) Military Medical Region III

    Science.gov (United States)

    1988-05-01

    I rerr syttemn an do wlon t P ontimal military inter-instittiuonal patient referral systems model for DOD Military Medical Region III. A convenience...Dactin- on the Armed Services Medical Regulating Office and Patient Airlift "lc rcsusl.s of :his study indicated that the single largest breakdown...and the requirement to regulate to the closest medical facility with capability to care for the patient . L! / I Ii I i A STUDY TO DEVELOP THE OPTIMAL

  1. Regulation

    International Nuclear Information System (INIS)

    Ballereau, P.

    1999-01-01

    The different regulations relative to nuclear energy since the first of January 1999 are given here. Two points deserve to be noticed: the decree of the third august 1999 authorizing the national Agency for the radioactive waste management to install and exploit on the commune of Bures (Meuse) an underground laboratory destined to study the deep geological formations where could be stored the radioactive waste. The second point is about the uranium residues and the waste notion. The judgment of the administrative tribunal of Limoges ( 9. july 1998) forbidding the exploitation of a storage installation of depleted uranium considered as final waste and qualifying it as an industrial waste storage facility has been annulled bu the Court of Appeal. It stipulated that, according to the law number 75663 of the 15. july 1965, no criteria below can be applied to depleted uranium: production residue (possibility of an ulterior enrichment), abandonment of a personal property or simple intention to do it ( future use aimed in the authorization request made in the Prefecture). This judgment has devoted the primacy of the waste notion on this one of final waste. (N.C.)

  2. The regulation for delivery of subsidies for measures of promoting power source location for nuclear power generating facilities

    International Nuclear Information System (INIS)

    1979-01-01

    The regulation is defined under the law for arrangement of surrounding areas of power generating facilities and the law concerning subsidies and others. Limits of the subsidies are stipulated respectively for establishment of a unit and simultaneous construction of more than 2 units of power generating facilities in the area of self-governing bodies concerned. Limits of the subsidies for an arrangement business out of the area of self-governing bodies where the facilities are set up shall be equal to those of the subsidies for such bodies. The Director General of Science and Technology Agency and the Minister of International Trade and Industry may make the amounts otherwise determined the limits of the subsidies, when considered necessary successfully to build the facilities. The term of delivery is from a fiscal year in which a later one of either the day of beginning of the construction concerned or the day of acknowledgment of the arrangement program of the business is included, through a fiscal year when the work finishes. An application for subsidies shall be filed to the head of the authorities concerned with gists of the business according to the forms attached. Receiving the application, the head of the authorities shall examine it and notify to the applicant without delay in writing the decision of delivery and its conditions, when such settlement is made. (Okada, K.)

  3. RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

    Science.gov (United States)

    Manfrini, Nicola; Trovesi, Camilla; Wery, Maxime; Martina, Marina; Cesena, Daniele; Descrimes, Marc; Morillon, Antonin; d'Adda di Fagagna, Fabrizio; Longhese, Maria Pia

    2015-02-01

    Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indicate that RNA-processing factors play critical, yet poorly understood, roles in genomic stability. Here, we provide evidence that the Saccharomyces cerevisiae RNA decay factors Xrn1, Rrp6 and Trf4 regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA. The lack of Xrn1 inhibits ssDNA generation at the DSB by preventing the loading of the MRX complex. By contrast, DSB resection is not affected in the absence of Rrp6 or Trf4, but their lack impairs the recruitment of RPA, and therefore of Mec1, to the DSB. Rrp6 and Trf4 inactivation affects neither Rad51/Rad52 association nor DSB repair by homologous recombination (HR), suggesting that full Mec1 activation requires higher amount of RPA-coated ssDNA than HR-mediated repair. Noteworthy, deep transcriptome analyses do not identify common misregulated gene expression that could explain the observed phenotypes. Our results provide a novel link between RNA processing and genome stability. © 2014 The Authors.

  4. Neural network-based voltage regulator for an isolated asynchronous generator supplying three-phase four-wire loads

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Bhim; Kasal, Gaurav Kumar [Department of Electrical Engineering, Indian Institute of Technology, Delhi, Hauz-Khas, New Delhi 110016 (India)

    2008-06-15

    This paper deals with a neural network-based solid state voltage controller for an isolated asynchronous generator (IAG) driven by constant speed prime mover like diesel engine, bio-gas or gasoline engine and supplying three-phase four-wire loads. The proposed control scheme uses an indirect current control and a fast adaptive linear element (adaline) based neural network reference current extractor, which extracts the real positive sequence current component without any phase shift. The neutral current of the source is also compensated by using three single-phase bridge configuration of IGBT (insulated gate bipolar junction transistor) based voltage source converter (VSC) along-with single-phase transformer having self-supported dc bus. The proposed controller provides the functions as a voltage regulator, a harmonic eliminator, a neutral current compensator, and a load balancer. The proposed isolated electrical system with its controller is modeled and simulated in MATLAB along with Simulink and PSB (Power System Block set) toolboxes. The simulated results are presented to demonstrate the capability of an isolated asynchronous generating system driven by a constant speed prime mover for feeding three-phase four-wire loads. (author)

  5. DoD Records Management Program

    National Research Council Canada - National Science Library

    Arnason, C

    1997-01-01

    ... title 36, Code of Federal Regulations, Chapter XII, 'National Archives and Records Administration,' Subchapter B, 'Records Management,' under the Assistant Secretary of Defense for Command, Control, Communications and Intelligence (ASD(C3I...

  6. 76 FR 38051 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2011-06-29

    ... Sexual Assault/Harassment Involving DoD Contractors During Contingency Operations,'' dated April 16, 2010... Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY... employees accompanying U.S. Armed Forces are made aware of the DoD definition of sexual assault as defined...

  7. 75 FR 73997 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2010-11-30

    ... Inspector General audit D-2010-052, entitled ``Efforts to Prevent Sexual Assault/Harassment Involving DoD... Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense..., to ensure contractor employees are aware of the DoD definition of ``sexual assault'' as defined in Do...

  8. DOD Eye Sensors to Give 'Urban Canyon Visibility

    National Research Council Canada - National Science Library

    Bender, Bryan

    2000-01-01

    Washington DC -- The US Department of Defense (DoD) is considering supplying troops with low-cost, disposable hand-held sensors that can be flised into an intelligence network accessible at the lowest levels on the future urban battlefield...

  9. Top DoD Management Challenges, Fiscal Year 2018

    Science.gov (United States)

    2018-01-01

    Providing Effective, Comprehensive, and Cost Effective Health Care 10. Identifying and Implementing Efficiencies in the DoD INSPECTOR GENERAL...8: Ensuring Ethical Conduct ................ 64 Challenge 9: Providing Effective, Comprehensive, and Cost Effective Health  Care...eroding ISIS physical caliphate in Iraq. INFLUENCE OF RUSSIA AND IRAN IN SYRIA In March 2017, General Votel testified that Iran poses the greatest

  10. Military Retirement and Wealth Forecasting During DOD Manpower Drawdown

    Science.gov (United States)

    2013-09-01

    SHAPING 1. DoD Perspective With the national debt approaching $17 trillion, the federal government is under fire to find ways to curb the momentum ...opportunities using a Bernoulli distribution to represent success and failure. The sampled in-zone and above-zone promotion probabilities were used as

  11. DOD/COCOM Water Security Program Strategy Document

    Science.gov (United States)

    2011-04-22

    treatment and disposal. DOD/COCOM Water Security Program Strategy 22 18. Toxic Minerals In regions where there are naturally occurring unsafe...surface hydrologic observations using remote sensing to provide data on precipitation, radiation, temperature, soil moisture, groundwater, snowcover...habitat alteration and aquaculture . 13. Centers for Disease Control (CDC) Works with partners throughout the nation and the world to monitor health

  12. Ballast Load Control of Turbine-Generator Sets in the Micro-Hydro Range with a Turbine that has no Flow Regulating Value

    Directory of Open Access Journals (Sweden)

    Valentin Nedelea

    2011-09-01

    Full Text Available This paper presents the effects of voltage and frequency variation on users load supplies from electrical supply system generated from small micro-hydro plants. Induction generators operate as stand-alone self excited by capacitors and turbine has no flow regulating valve. Many conventional and non conventional approaches are described to govern turbine-generator set to ensure a steady frequency and voltage level. A load controller increases or decreases a ballast load connected across the generator as the user load varies, to keep frequency and voltage variation in standard limits. To design a controller for self excited induction generator, researches were performed on asynchronous generator with double winding stator to analyse steady state open loop behaviour. The results on the behaviour of the unregulated turbine (DC motor – generator system was presented.

  13. Changes in Policy and Market and Network Regulation to Increase Power Generation by Renewables and DG in the EU

    International Nuclear Information System (INIS)

    Van Oostvoorn, F.; Van der Welle, A.

    2009-01-01

    Recently the importance of 'Large scale DER integration' has increased as means to meet the ambitious 2020 EU policy objectives and targets for RES, emissions reductions and energy efficiency. Increasing the role of RES and DG (Renewable Energy Sources and Distributed Generation or DER) in supply is also highly beneficial for reducing EU dependency on gas and oil imports. In this EU context, it is important to review the current barriers, support policies and network regulation for integration of more DG, RES and small scale CHP (Combined Heat and Power) in the power systems. Several studies conducted for the EU and led by the ECN (Energy research Centre of the Netherlands) reveal that currently, in some, mainly new, Member States, the contribution of RES and DG is still very low. However, in coming decades the share of variable RES-E sources should become much larger in many EU countries. Note that 20% RES in a country in 2020 implies a share of electricity supply by RES of about 30% or more. Currently, countries like Denmark and Spain, already experience such a large contribution of (mostly intermittent type) renewables and this is already negatively impacting power system costs. Now the question arises whether or not we can increase the contribution of RES to the power supply beyond 20-30% without raising system inefficiency and what changes in system conditions and market and network regulation are necessary to efficiently absorb large volumes of so called intermittent RES supply resources. Based on findings from several large EU projects promoting the role of RES and DG in the power supply, the authors discuss and present the different barriers and solutions that should facilitate meeting the ambitious EU policy targets for RES in 2020

  14. DoD Key Technologies Plan

    Science.gov (United States)

    1992-07-01

    cryoelec- devices with high tronics. mobility semiconduc- - Demonstration of HTS * Demonstration of HTS tors and magnetic interconnects and high motor ...for rotating electrical machine is 1 kJ/kg, which is the capability of the most compact existing pulse power supply: a homopolar generator/inductor...of the art from 0.2 up to 2 Id/k.g several years ago, using a homopolar generator/inductor combination for single shot rep-ratcs. Fabrication of a

  15. Summary of DoD Office of the Inspector General Audits of DoD Financial Management Challenges

    Science.gov (United States)

    2015-07-07

    were not always recorded using accrual accounting . Additionally, Army systems did not always record the transaction on an accrual basis as...mission is to provide independent, relevant, and timely oversight of the Department of Defense that supports the warfighter; promotes accountability ...financial management. The most prevalent areas of concern were DoD financial management systems, accounting entries, compliance with laws and

  16. Regulation of Na(+)/K(+)-ATPase by nuclear respiratory factor 1: implication in the tight coupling of neuronal activity, energy generation, and energy consumption.

    Science.gov (United States)

    Johar, Kaid; Priya, Anusha; Wong-Riley, Margaret T T

    2012-11-23

    NRF-1 regulates mediators of neuronal activity and energy generation. NRF-1 transcriptionally regulates Na(+)/K(+)-ATPase subunits α1 and β1. NRF-1 functionally regulates mediators of energy consumption in neurons. NRF-1 mediates the tight coupling of neuronal activity, energy generation, and energy consumption at the molecular level. Energy generation and energy consumption are tightly coupled to neuronal activity at the cellular level. Na(+)/K(+)-ATPase, a major energy-consuming enzyme, is well expressed in neurons rich in cytochrome c oxidase, an important enzyme of the energy-generating machinery, and glutamatergic receptors that are mediators of neuronal activity. The present study sought to test our hypothesis that the coupling extends to the molecular level, whereby Na(+)/K(+)-ATPase subunits are regulated by the same transcription factor, nuclear respiratory factor 1 (NRF-1), found recently by our laboratory to regulate all cytochrome c oxidase subunit genes and some NMDA and AMPA receptor subunit genes. By means of multiple approaches, including in silico analysis, electrophoretic mobility shift and supershift assays, in vivo chromatin immunoprecipitation, promoter mutational analysis, and real-time quantitative PCR, NRF-1 was found to functionally bind to the promoters of Atp1a1 and Atp1b1 genes but not of the Atp1a3 gene in neurons. The transcripts of Atp1a1 and Atp1b1 subunit genes were up-regulated by KCl and down-regulated by tetrodotoxin. Atp1b1 is positively regulated by NRF-1, and silencing of NRF-1 with small interference RNA blocked the up-regulation of Atp1b1 induced by KCl, whereas overexpression of NRF-1 rescued these transcripts from being suppressed by tetrodotoxin. On the other hand, Atp1a1 is negatively regulated by NRF-1. The binding sites of NRF-1 on Atp1a1 and Atp1b1 are conserved among mice, rats, and humans. Thus, NRF-1 regulates key Na(+)/K(+)-ATPase subunits and plays an important role in mediating the tight coupling between

  17. An Improved Path-Generating Regulator for Two-Wheeled Robots to Track the Circle/Arc Passage

    Directory of Open Access Journals (Sweden)

    Jun Dai

    2014-01-01

    Full Text Available The improved path-generating regulator (PGR is proposed to path track the circle/arc passage for two-wheeled robots. The PGR, which is a control method for robots so as to orient its heading toward the tangential direction of one of the curves belonging to the family of path functions, is applied to navigation problem originally. Driving environments for robots are usually roads, streets, paths, passages, and ridges. These tracks can be seen as they consist of straight lines and arcs. In the case of small interval, arc can be regarded as straight line approximately; therefore we extended the PGR to drive the robot move along circle/arc passage based on the theory that PGR to track the straight passage. In addition, the adjustable look-ahead method is proposed to improve the robot trajectory convergence property to the target circle/arc. The effectiveness is proved through MATLAB simulations on both the comparisons with the PGR and the improved PGR with adjustable look-ahead method. The results of numerical simulations show that the adjustable look-ahead method has better convergence property and stronger capacity of resisting disturbance.

  18. Determination of permissible doses under the provisions of the regulations on installation and operation of reactors for power generation

    International Nuclear Information System (INIS)

    1979-01-01

    The determination is defined under the regulations on installation and operation of reactors for power generation. In the controlled area exterior radiation dose shall be 30 mili-rem for a week by the Minister of International Trade and Industry. The concentrations of radioactive materials in the air or under the water shall be permissible concentrations specified for the employees multiplied by 0.75 in average for a week. The densities of radioactive materials on the surface of the things contaminated by such materials shall be 1/10 of permissible surface densities stipulated in the table attached. Permissible exposure dose outside the inspected surrounding area is 0.5 rem for a year. Permissible surface densities are included in the table attached. Permissible accumulative dose for the employees is the figure (unit rem) calculated by the formula D = 5(N-18), when D means permissible accumulative dose and N number of the age. Permissible exposure dose is 3 rem for 3 months for the employees, 1.5 rem for a year for persons other than the employees and 12 rem for the urgent work. Permissible concentrations are defined in detail for the employees and outside the inspected surrounding area. Calculation of exposure dose in the case of interior exposure is particularly provided for. (Okada, K.)

  19. Graph Generator Survey

    Energy Technology Data Exchange (ETDEWEB)

    Lothian, Joshua [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Powers, Sarah S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sullivan, Blair D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Baker, Matthew B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schrock, Jonathan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Poole, Stephen W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2013-10-01

    The benchmarking effort within the Extreme Scale Systems Center at Oak Ridge National Laboratory seeks to provide High Performance Computing benchmarks and test suites of interest to the DoD sponsor. The work described in this report is a part of the effort focusing on graph generation. A previously developed benchmark, SystemBurn, allowed the emulation of different application behavior profiles within a single framework. To complement this effort, similar capabilities are desired for graph-centric problems. This report examines existing synthetic graph generator implementations in preparation for further study on the properties of their generated synthetic graphs.

  20. Military Standard Generators Prototype Modifications. Volume 2. 30 kW DoD Generator Set

    Science.gov (United States)

    1988-03-31

    GE14 SET S,./14 KZO 5EJ41 70 KM,,*68 ý0 GEN S¢ET SIRN tɘ 5841 C 1 EXHAUST ± 484.71 DEG. F C I EXHAUST ± 545. 67 DEG. F C 2 EXHAUST 2 473.2-9 DEG. F...584t ý󈧣 Kid.- N Z GE14 SET SoN K20 584 ±i EXHAUST ± 85.64 bEG. F C. EXHAUST 1 062.12 DEG. F C 2 EXHAUSIT 2 75854 PEG.F C 2 EXHAUST 2 7M2± DEG. F c 7...E: 2ŗ GE14 . UVLT. P.RG. 78. 165 DEIG. F AL". C 23 GEN. UDLT. RIG. 69..945 DEG. F AL? C: 24 r:D[4TROL PANEL 68S.7 35% DEG. F ALM! C 24 CO4TRTOL PANEL

  1. Coordinated Multi-Objective Control of Regulating Resources in Multi-Area Power Systems with Large Penetration of Wind Power Generation

    DEFF Research Database (Denmark)

    Nyeng, Preben; Yang, Bo; Ma, Jian

    2008-01-01

    This paper describes a control algorithm for a Wide Area Energy Storage and Management System (WAEMS). The WAEMS is designed to meet the demand for fast, accurate and reliable regulation services in multi-area power systems with a significant share of wind power and other intermittent generation...

  2. Resolution 8.069/012 It approval the regulations for the installation of of great bearing structures, intended for wind power generation

    International Nuclear Information System (INIS)

    2012-01-01

    This resolution is about: regulations made by the Florida Administration, Oriental Republic of Uruguay to locate of great bearing structures intended for wind power generation.At the same time they have been included them :definition, objectives, installation rights, site areas, minimum distances, presentation, technical responsibility, maintenance, external documentation

  3. Function generation and regulation libraries and their application to the control of the new main power converter (POPS) at the CERN CPS

    International Nuclear Information System (INIS)

    King, Q.; Page, S.T.; Thiesen, H.; Veenstra, M.

    2012-01-01

    Power converter control for the LHC is based on an embedded control computer called a Function Generator/Controller (FGC). Every converter includes an FGC with responsibility for the generation of the reference current as a function of time and the regulation of the circuit current, as well as control of the converter state. With many new converter controls software classes in development it was decided to generalize several key components of the FGC software in the form of C libraries: function generation in libfg, regulation, limits and simulation in libreg and DCCT, ADC and DAC calibration in libcal. These libraries were first used in the software class dedicated to controlling the new 60 MW main power converter (POPS) at the CERN Proton Synchrotron (CPS) where regulation of both magnetic field and circuit current is supported. This paper reports on the functionality provided by each library and in particular libfg and libreg. The libraries are already being used by software classes in development for the next generation FGC for Linac4 converters, as well as the CERN SPS converter controls (MUGEF) and MedAustron converter regulation board. (authors)

  4. DoD Modeling and Simulation (M&S) Glossary

    Science.gov (United States)

    1998-01-01

    i 66 January 1998 DoD 5000.59-M SSTORM STAARS STADLS STAF STAFLO STAGE STAMIS STARS I » STDL STDN STE STEMS STEP STM STOW STOW...references (b) and (c)) 556. World Coordinate System. The right-handed geocentric Cartesian system. The shape of the world is described by the...557. World Geodetic System 1984 (WGS 84). A geocentric coordinate system which describes a basic frame of reference and geometric figure for the

  5. Optimizing security of cloud computing within the DoD

    OpenAIRE

    Antedomenico, Noemi

    2010-01-01

    Approved for public release; distribution is unlimited What countermeasures best strengthen the confidentiality, integrity and availability (CIA) of the implementation of cloud computing within the DoD? This question will be answered by analyzing threats and countermeasures within the context of the ten domains comprising the Certified Information System Security Professional (CISSP) Common Body of Knowledge (CBK). The ten domains that will be used in this analysis include access control; ...

  6. DoD Freedom of Information Act Policies Need Improvement

    Science.gov (United States)

    2016-08-16

    of Defense that supports the warfighter; promotes accountability, integrity, and efficiency; advises the Secretary of Defense and Congress; and...General (DoD OIG) determine whether noncareer officials (political appointees or persons nominated by the President and confirmed by the U.S...officials unduly influencing the FOIA response process. On November 9, 2015, we advised the Chairman of the Senate Committee on Homeland Security

  7. DoD Civilian Training: Source, Content, Frequency and Cost

    Science.gov (United States)

    1994-03-01

    statistics. This especially includes Mr. Mike Dove, Ms. Kris Hoffman, Ms. Ninfa Camargo , Mr. Edward Christie, Ms. Rebecca Tag, Ms. Elizabeth Kundift Ms...Center, San Francisco , CA, will close. DoD Civilian Training Study Page 10 Chapter 2: Source There were 1,507 civilians trained We learned that 166...San Diego, CA Service School Command 13 60 San Diego, CA Submarine Training Facility 4 61 San Francisco , CA Naval Technical Training Center 13 62

  8. DoD Task Force to Improve Industrial Responsiveness.

    Science.gov (United States)

    1982-03-01

    stable programs list. Stable programs will generally not be decremented or subject to offset actions during budget pre- paration as a result of cuts to...with DOD Directive 6050.1 (reference MDf ). 6 _7 ~~o _,N’ "N7 N(- .T’ 5000.2 (Encl 4) 6 JUSTIIICATIOI FOR MAJOR SYSTEM NEW START (JMSNS) - FORMAT...equipment. 4. Deficiencies in the survivability (nuclear, conventional, chemical, 0 laser , electromagnetic warfare, etc.) or endurance of existing

  9. Defense Business Transformation: DOD Should Improve Its Planning with and Performance Monitoring of the Military Departments

    Science.gov (United States)

    2016-12-01

    transformation as high risk in 2005 because DOD had not taken steps to achieve business reform on a strategic , department-wide basis. This report (1...Government Accountability Office Highlights of GAO-17-9, a report to congressional addresses December 2016 DEFENSE BUSINESS TRANSFORMATION DOD Should... strategic or business transformation plans, but DOD has not coordinated with the military departments to align their strategic planning efforts for

  10. DoD Information Security Program and Protection of Sensitive Compartmented Information (SCI)

    Science.gov (United States)

    2016-04-21

    Sensitive Compartmented Information ( SCI ) References: See Enclosure 1 1. PURPOSE. In accordance with the authority in DoD Directive (DoDD...collateral, special access program, SCI , and controlled unclassified information (CUI) within an overarching DoD Information Security Program...use, and dissemination of SCI within the DoD pursuant to References (a), (c), and (e) and Executive Order 12333 (Reference (h)). 2

  11. Assessing Climate Change Risks: Lessons Learned from DoD Installations in the Southwest

    Science.gov (United States)

    2017-08-01

    adaptation strategies that are aligned with DoD facilities management . Our overall guidance for climate decision-making is consistent with our original ...process of integrating climate change risk 46 management into existing business processes. With a few exceptions, the sharing of practical...Climate Change Impacts and Adaptation on Southwestern DoD Facilities and is offered as a collection of resources that DoD managers can use to plan and

  12. Renewable Energy Production from DoD Installation Solid Wastes by Anaerobic Digestion

    Science.gov (United States)

    2016-06-01

    ENGINEERING GUIDANCE REPORT Renewable Energy Production from DoD Installation Solid Wastes by Anaerobic Digestion ESTCP Project ER-200933 JUNE...Defense. Page Intentionally Left Blank Renewable Energy Production From DoD Installation Solid Wastes by Anaerobic Digestion ii June 2016 REPORT...3. DATES COVERED (2009 – 2016) 4. TITLE AND SUBTITLE Renewable Energy Production from DoD Installation Solid Wastes by Anaerobic Digestion 5a

  13. The critical examination of X-ray generating equipment in diagnostic radiology. Guidance on the interpretation of the Ionising Radiation Regulations 1985, Regulation 32(2)a

    International Nuclear Information System (INIS)

    1998-01-01

    Regulation 32(2)a requires an examination, where appropriate, of X-ray equipment and its operating environment, following its installation, repair or modification. In this context 'appropriate' means - 'if there are possible radiation protection implications'. The examination should be carried out before the equipment is brought into use. The intent of the Regulation is to ensure that the installation process does not compromise the radiation safety of the equipment as provided for by its original design and manufacture, and that any persons who might be exposed are adequately protected. However, the scope of the Regulation does not directly cover features controlling the optimisation of dose for a medical exposure. An examination of the equipment relating to the radiation protection consequences of the way it was installed is required. This is termed 'critical', emphasising the need to review the installation to a greater degree than the simple fulfilment of a preconceived test procedure. The involvement of a radiation protection adviser is required as an expert in radiation safety. This document provides guidance on when it is necessary to carry out a critical examination, and on its content. The Ionising Radiations Regulations 1985 firmly place the responsibility for ensuring that a critical examination is carried out, on the installer of the equipment. However, knowledge of various aspects of the critical examination is also relevant to employers who manage health related facilities, as well as their RPAs, and physicists who carry out equipment tests. Aside from the actual examination itself, there are issues pertaining to purchase contracts, and a knowledge of the satisfactory completion of a critical examination will be relevant to an employer in fulfilling his duties under Regulations 6 and 33. (author)

  14. The critical examination of X-ray generating equipment in diagnostic radiology. Guidance on the interpretation of the Ionising Radiation Regulations 1985, Regulation 32(2)a

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    Regulation 32(2)a requires an examination, where appropriate, of X-ray equipment and its operating environment, following its installation, repair or modification. In this context 'appropriate' means - 'if there are possible radiation protection implications'. The examination should be carried out before the equipment is brought into use. The intent of the Regulation is to ensure that the installation process does not compromise the radiation safety of the equipment as provided for by its original design and manufacture, and that any persons who might be exposed are adequately protected. However, the scope of the Regulation does not directly cover features controlling the optimisation of dose for a medical exposure. An examination of the equipment relating to the radiation protection consequences of the way it was installed is required. This is termed 'critical', emphasising the need to review the installation to a greater degree than the simple fulfilment of a preconceived test procedure. The involvement of a radiation protection adviser is required as an expert in radiation safety. This document provides guidance on when it is necessary to carry out a critical examination, and on its content. The Ionising Radiations Regulations 1985 firmly place the responsibility for ensuring that a critical examination is carried out, on the installer of the equipment. However, knowledge of various aspects of the critical examination is also relevant to employers who manage health related facilities, as well as their RPAs, and physicists who carry out equipment tests. Aside from the actual examination itself, there are issues pertaining to purchase contracts, and a knowledge of the satisfactory completion of a critical examination will be relevant to an employer in fulfilling his duties under Regulations 6 and 33. (author)

  15. The management of electronic documents generated from compilation and revision processes of nuclear and radiation safety regulations and standards

    International Nuclear Information System (INIS)

    Wang Wenhai; Fan Yun; Shang Zhaorong

    2010-01-01

    As the Secretary Group of Regulations and Standards Review Committee on nuclear and radiation safe needs to deal with a large number of electronic documents in course of the regulation and standard review meetings, the article gives a systematical method including electronic document file naming and management as well as procedures of file transfer, storage and usage. (authors)

  16. Natural gas and the generation of electricity in relation to environmental protection regulations in EC member countries

    International Nuclear Information System (INIS)

    Fosenbauer, T.

    1994-01-01

    A brief account is given of regulations governing the use of gas in power plants, of emission limits for some substances such as SO 2 , NO x and dust, and of regulations concerning existing and newly built facilities, specifying the highest permissible emissions of environmental pollutants. (J.B.)

  17. 76 FR 72391 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-11-23

    ... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Revised Defense Logistics Agency...

  18. Defense Inventory: Opportunities Exist to Improve the Management of DOD's Acquisition Lead Times for Spare Parts

    National Research Council Canada - National Science Library

    2007-01-01

    .... Management of inventory acquisition lead times is important in maintaining cost-effective inventories, budgeting, and having material available when needed, as lead times are DOD's best estimate...

  19. Carbon Sequestration and Forest Management at DoD Installations: An Exploratory Study

    National Research Council Canada - National Science Library

    Barker, Jerry

    1995-01-01

    .... The primary purpose of this report is to explore the influence of management practices such as tree harvesting, deforestation, and reforestation on carbon sequestration potential by DOD forests...

  20. Military Operations: DOD Needs to Address Contract Oversight and Quality Assurance Issues for Contracts Used to Support Contingency Operations

    National Research Council Canada - National Science Library

    Solis, William M; Coffey, Carole; Baker, Sarah; Brown, Renee; Junek, Larry; La Due Lake, Ronald; Lenane, Katherine; Mason, Susan; Sawyer, Jr., Connie W; Thornton, Karen

    2008-01-01

    .... In its fiscal year 2007 report, the House Appropriations Committee directed GAO to examine the link between the growth in DOD's operation and maintenance costs and DOD's increased reliance on service contracts. GAO determined (1...

  1. CAC on a MAC: Setting up a DOD Common Access Card Reader on the Macintosh OS X Operating System

    National Research Council Canada - National Science Library

    Hopfner, Phil

    2006-01-01

    .... The CAC readers in conjunction with the user's Smart Card enables access to DoD PKI-enabled websites and allows the user to send signed and encrypted email utilizing the DoD Public Key Infrastructure (PKI...

  2. Defense Management: Overarching Organizational Framework Could Improve DoD's Management of Energy Reduction Efforts for Military Operations

    National Research Council Canada - National Science Library

    Solis, William M

    2008-01-01

    .... Fuel costs for DOD are substantial and the volatility of world oil prices will likely continue to affect the department which may require DOD to make difficult trade-offs, such as redirecting funds...

  3. 77 FR 60746 - Proposed Information Collection (VA/DOD Joint Disability Evaluation Board Claim) Activity...

    Science.gov (United States)

    2012-10-04

    ... burden of the collection of information on respondents, including through the use of automated collection techniques or the use of other forms of information technology. Title: VA/DOD Joint Disability Evaluation... War on Terror Heroes, VA and the Department of Defense (DOD) have agreed to develop a joint process in...

  4. 32 CFR Appendix B to Part 223 - Guidelines for the Determination of DoD UCNI

    Science.gov (United States)

    2010-07-01

    ... information in another document or material is not, or is no longer, DoD UCNI; case-by-case determinations are... description of security system components intended to mitigate the consequences of an accident or act of... construction drawings of a DoD SNM facility showing construction characteristics of building and associated...

  5. Prescription Drugs: Comparison of DOD, Medicaid, and Medicare Part D Retail Reimbursement Prices

    Science.gov (United States)

    2014-06-01

    information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215...Medicaid Services DIR direct and indirect remuneration DOD Department of Defense FCP federal ceiling price HCPCS Healthcare Common Procedure...prices, we used PDTS data from DOD; unit rebate amount (URA) and CMS-64 data from Medicaid; and the 2010 Direct and Indirect Remuneration (DIR

  6. 75 FR 59176 - DoD Mandatory Declassification Review (MDR) Program

    Science.gov (United States)

    2010-09-27

    ..., VA 22060-6201. (13) Missile Defense Agency. Missile Defense Agency, Attention: MDA/DS, 7100 Defense... DEPARTMENT OF DEFENSE Office of the Secretary 32 CFR Part 222 [DoD-2010-OS-0043; RIN 0790-AI62] DoD Mandatory Declassification Review (MDR) Program AGENCY: Department of Defense. ACTION: Proposed...

  7. Report on the Audit of DoD Immunity From State Taxation

    Science.gov (United States)

    1991-02-15

    This is our final report on the audit of DOD Immunity from State Taxation for your information and use. We made the audit from July to September 1990...The objective of the audit was to determine whether DoD was unnecessarily paying state sales taxes. We also determined if sales taxes were being

  8. 77 FR 12577 - Department of Defense (DoD) Board of Actuaries; Federal Advisory Committee Meeting

    Science.gov (United States)

    2012-03-01

    ... DEPARTMENT OF DEFENSE Office of the Secretary Department of Defense (DoD) Board of Actuaries... that the following Federal advisory committee meeting of the DoD Board of Actuaries will take place... Actuaries meeting or make an oral presentation or submit a written statement for consideration at the...

  9. 75 FR 6359 - Federal Advisory Committee; DoD Board of Actuaries; Meeting

    Science.gov (United States)

    2010-02-09

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; DoD Board of Actuaries... the DoD Board of Actuaries will meet on July 22 and 23, 2010. Subject to the availability of space...D Office of the Actuary, 4040 N. Fairfax Drive, Suite 308, Arlington, VA 22203; phone 703-696-7413...

  10. Does environmental regulation affect energy efficiency in China's thermal power generation? Empirical evidence from a slacks-based DEA model

    International Nuclear Information System (INIS)

    Bi, Gong-Bing; Song, Wen; Zhou, P.; Liang, Liang

    2014-01-01

    Data envelopment analysis (DEA) has gained much popularity in performance measurement of power industry. This paper presents a slack-based measure approach to investigating the relationship between fossil fuel consumption and the environmental regulation of China's thermal power generation. We first calculate the total-factor energy efficiency without considering environmental constraints. An environmental performance indicator is proposed through decomposing the total-factor energy efficiency. The proposed approach is then employed to examine whether environmental regulation affects the energy efficiency of China's thermal power generation. We find that the environmental efficiency plays a significant role in affecting energy performance of China's thermal generation sector. Decreasing the discharge of major pollutants can improve both energy performance and environmental efficiency. Besides, we also have three main findings: (1) The energy efficiency and environmental efficiency were relatively low. (2) The energy and environmental efficiency scores show great variations among provinces. (3) Both energy efficiency and environmental efficiency are of obvious geographical characteristics. According to our findings, we suggest some policy implications. - Highlights: • We assess the energy efficiency and the environmental efficiency of China's thermal power generation simultaneously. • The energy efficiency and the environmental efficiency were relatively low during 2007–2009. • The energy efficiency and environmental efficiency show obvious geographic characters. • The environmental performance of a DMU plays a decisive role in the energy performance

  11. Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment.

    Science.gov (United States)

    Girada, Shravan Babu; Kuna, Ramya S; Bele, Shilpak; Zhu, Zhimeng; Chakravarthi, N R; DiMarchi, Richard D; Mitra, Prasenjit

    2017-10-01

    Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and recycling back to the plasma membrane, or it undergoes lysosomal degradation. Recent reports highlight specific cases of persistent cyclic AMP generation by internalized GPCRs, although the functional significance and mechanistic details remain to be defined. Cyclic AMP generation from internalized Glucagon-Like Peptide-1 Receptor (GLP-1R) has previously been reported from our laboratory. This study aimed at deciphering the molecular mechanism by which internalized GLP-R supports sustained cyclic AMP generation upon receptor activation in pancreatic beta cells. We studied the time course of cyclic AMP generation following GLP-1R activation with particular emphasis on defining the location where cyclic AMP is generated. Detection involved a novel GLP-1 conjugate coupled with immunofluorescence using specific endosomal markers. Finally, we employed co-immunoprecipitation as well as immunofluorescence to assess the protein-protein interactions that regulate GLP-1R mediated cyclic AMP generation at endosomes. Our data reveal that prolonged association of G protein α subunit Gαs with activated GLP-1R contributed to sustained cyclic AMP generation at Rab 5 endosomal compartment. The findings provide the mechanism of endosomal cyclic AMP generation following GLP-1R activation. We identified the specific compartment that serves as an organizing center to generate endosomal cyclic AMP by internalized activated receptor complex. Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved.

  12. An Analysis Of The Benefits And Application Of Earned Value Management (EVM) Project Management Techniques For Dod Programs That Do Not Meet Dod Policy Thresholds

    Science.gov (United States)

    2017-12-01

    VALUE MANAGEMENT (EVM) PROJECT MANAGEMENT TECHNIQUES FOR DOD PROGRAMS THAT DO NOT MEET DOD POLICY THRESHOLDS December 2017 By: Randy Schneider...Joint applied project 4. TITLE AND SUBTITLE AN ANALYSIS OF THE BENEFITS AND APPLICATION OF EARNED VALUE MANAGEMENT (EVM) PROJECT MANAGEMENT ...performance reporting. The immediate objective of this research project was to examine the question: Can the application of EVM-Lite project management

  13. Teleport Generation 3 (Teleport Gen 3)

    Science.gov (United States)

    2016-03-01

    for high- throughput multi-band and multimedia connectivity from deployed locations to DISN and DoD Information Network (DoDIN) information sources and...2016 Major Automated Information System Annual Report Teleport Generation 3 (Teleport Gen 3) Defense Acquisition Management Information Retrieval...Program Information 4 Responsible Office 4 References 4 Program Description 5 Business Case 6 Program Status 8 Schedule 9

  14. The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals.

    Science.gov (United States)

    Nautiyal, Jaya; Steel, Jennifer H; Mane, Meritxell Rosell; Oduwole, Olayiwola; Poliandri, Ariel; Alexi, Xanthippi; Wood, Nicholas; Poutanen, Matti; Zwart, Wilbert; Stingl, John; Parker, Malcolm G

    2013-03-01

    Nuclear receptor interacting protein (Nrip1), also known as RIP140, is a co-regulator for nuclear receptors that plays an essential role in ovulation by regulating the expression of the epidermal growth factor-like family of growth factors. Although several studies indicate a role for RIP140 in breast cancer, its role in the development of the mammary gland is unclear. By using RIP140-null and RIP140 transgenic mice, we demonstrate that RIP140 is an essential factor for normal mammary gland development and that it functions by mediating oestrogen signalling. RIP140-null mice exhibit minimal ductal elongation with no side-branching, whereas RIP140-overexpressing mice show increased cell proliferation and ductal branching with age. Tissue recombination experiments demonstrate that RIP140 expression is required in both the mammary epithelial and stromal compartments for ductal elongation during puberty and that loss of RIP140 leads to a catastrophic loss of the mammary epithelium, whereas RIP140 overexpression augments the mammary basal cell population and shifts the progenitor/differentiated cell balance within the luminal cell compartment towards the progenitors. For the first time, we present a genome-wide global view of oestrogen receptor-α (ERα) binding events in the developing mammary gland, which unravels 881 ERα binding sites. Unbiased evaluation of several ERα binding sites for RIP140 co-occupancy reveals selectivity and demonstrates that RIP140 acts as a co-regulator with ERα to regulate directly the expression of amphiregulin (Areg), the progesterone receptor (Pgr) and signal transducer and activator of transcription 5a (Stat5a), factors that influence key mitogenic pathways that regulate normal mammary gland development.

  15. 77 FR 12577 - Department of Defense (DoD) Medicare-Eligible Retiree Health Care Board of Actuaries; Federal...

    Science.gov (United States)

    2012-03-01

    ... Retiree Health Care Board of Actuaries; Federal Advisory Committee Meeting AGENCY: DoD. ACTION: Meeting... DoD Medicare-Eligible Retiree Health Care Board of Actuaries will take place. DATES: Friday, August 3... Contact: Persons desiring to attend the DoD Medicare- Eligible Retiree Health Care Board of Actuaries...

  16. 78 FR 46781 - Federal Acquisition Regulation; Definition of Contingency Operation

    Science.gov (United States)

    2013-08-01

    ... Federal Acquisition Regulation; Definition of Contingency Operation AGENCY: Department of Defense (DoD... the Federal Acquisition Regulation (FAR) to revise the definition of ``contingency operation'' to... ``contingency operation'' at FAR 2.101 in accordance with the statutory change to the definition made by...

  17. 78 FR 13765 - Federal Acquisition Regulation; Definition of Contingency Operation

    Science.gov (United States)

    2013-02-28

    ... Federal Acquisition Regulation; Definition of Contingency Operation AGENCY: Department of Defense (DoD... Regulation (FAR) to revise the definition of ``contingency operation'' to address the statutory change to the... ``contingency operation'' at FAR 2.101 in accordance with the statutory change to the definition made by...

  18. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Travel Costs

    Science.gov (United States)

    2012-11-09

    ...; Information Collection; Travel Costs AGENCY: Department of Defense (DOD), General Services Administration (GSA... requirement concerning Travel Costs. Public comments are particularly invited on: Whether this collection of...- 0088, Travel Costs by any of the following methods: Regulations.gov : http://www.regulations.gov...

  19. High voltage dc-dc converter with dynamic voltage regulation and decoupling during load-generated arcs

    Science.gov (United States)

    Shimer, Daniel W.; Lange, Arnold C.

    1995-01-01

    A high-power power supply produces a controllable, constant high voltage output under varying and arcing loads. The power supply includes a voltage regulator, an inductor, an inverter for producing a high frequency square wave current of alternating polarity, an improved inverter voltage clamping circuit, a step up transformer, an output rectifier for producing a dc voltage at the output of each module, and a current sensor for sensing output current. The power supply also provides dynamic response to varying loads by controlling the voltage regulator duty cycle and circuitry is provided for sensing incipient arc currents at the output of the power supply to simultaneously decouple the power supply circuitry from the arcing load. The power supply includes a plurality of discrete switching type dc--dc converter modules.

  20. High voltage dc--dc converter with dynamic voltage regulation and decoupling during load-generated arcs

    Science.gov (United States)

    Shimer, D.W.; Lange, A.C.

    1995-05-23

    A high-power power supply produces a controllable, constant high voltage output under varying and arcing loads. The power supply includes a voltage regulator, an inductor, an inverter for producing a high frequency square wave current of alternating polarity, an improved inverter voltage clamping circuit, a step up transformer, an output rectifier for producing a dc voltage at the output of each module, and a current sensor for sensing output current. The power supply also provides dynamic response to varying loads by controlling the voltage regulator duty cycle and circuitry is provided for sensing incipient arc currents at the output of the power supply to simultaneously decouple the power supply circuitry from the arcing load. The power supply includes a plurality of discrete switching type dc--dc converter modules. 5 Figs.

  1. A charge regulating system for turbo-generator gas-cooled high-temperature reactor power stations

    International Nuclear Information System (INIS)

    Braytenbah, A.S.; Jaegtnes, K.O.

    1975-01-01

    The invention relates to a regulating system for gas-cooled high-temperature reactors power stations (helium coolant), equipped with several steam-boilers, each of which deriving heat from a corresponding cooling-gas flow circulating in the reactor, so as to feed superheated steam into a main common steam-manifold and re-superheated steam into a re-superheated hot common manifold [fr

  2. Regulators of nonsulfur purple phototrophic bacteria and the interactive control of CO2 assimilation, nitrogen fixation, hydrogen metabolism and energy generation.

    Science.gov (United States)

    Dubbs, James M; Tabita, F Robert

    2004-06-01

    For the metabolically diverse nonsulfur purple phototrophic bacteria, maintaining redox homeostasis requires balancing the activities of energy supplying and energy-utilizing pathways, often in the face of drastic changes in environmental conditions. These organisms, members of the class Alphaproteobacteria, primarily use CO2 as an electron sink to achieve redox homeostasis. After noting the consequences of inactivating the capacity for CO2 reduction through the Calvin-Benson-Bassham (CBB) pathway, it was shown that the molecular control of many additional important biological processes catalyzed by nonsulfur purple bacteria is linked to expression of the CBB genes. Several regulator proteins are involved, with the two component Reg/Prr regulatory system playing a major role in maintaining redox poise in these organisms. Reg/Prr was shown to be a global regulator involved in the coordinate control of a number of metabolic processes including CO2 assimilation, nitrogen fixation, hydrogen metabolism and energy-generation pathways. Accumulating evidence suggests that the Reg/Prr system senses the oxidation/reduction state of the cell by monitoring a signal associated with electron transport. The response regulator RegA/PrrA activates or represses gene expression through direct interaction with target gene promoters where it often works in concert with other regulators that can be either global or specific. For the key CO2 reduction pathway, which clearly triggers whether other redox balancing mechanisms are employed, the ability to activate or inactivate the specific regulator CbbR is of paramount importance. From these studies, it is apparent that a detailed understanding of how diverse regulatory elements integrate and control metabolism will eventually be achieved.

  3. A new DoD initiative: the Computational Research and Engineering Acquisition Tools and Environments (CREATE) program

    International Nuclear Information System (INIS)

    Arevalo, S; Atwood, C; Bell, P; Blacker, T D; Dey, S; Fisher, D; Fisher, D A; Genalis, P; Gorski, J; Harris, A; Hill, K; Hurwitz, M; Kendall, R P; Meakin, R L; Morton, S; Moyer, E T; Post, D E; Strawn, R; Veldhuizen, D v; Votta, L G

    2008-01-01

    In FY2008, the U.S. Department of Defense (DoD) initiated the Computational Research and Engineering Acquisition Tools and Environments (CREATE) program, a $360M program with a two-year planning phase and a ten-year execution phase. CREATE will develop and deploy three computational engineering tool sets for DoD acquisition programs to use to design aircraft, ships and radio-frequency antennas. The planning and execution of CREATE are based on the 'lessons learned' from case studies of large-scale computational science and engineering projects. The case studies stress the importance of a stable, close-knit development team; a focus on customer needs and requirements; verification and validation; flexible and agile planning, management, and development processes; risk management; realistic schedules and resource levels; balanced short- and long-term goals and deliverables; and stable, long-term support by the program sponsor. Since it began in FY2008, the CREATE program has built a team and project structure, developed requirements and begun validating them, identified candidate products, established initial connections with the acquisition programs, begun detailed project planning and development, and generated the initial collaboration infrastructure necessary for success by its multi-institutional, multidisciplinary teams

  4. Fractional order nonlinear variable speed and current regulation of a permanent magnet synchronous generator wind turbine system

    Directory of Open Access Journals (Sweden)

    Anitha Karthikeyan

    2018-03-01

    Full Text Available In this paper we derived the fractional order model of the Permanent Magnet Synchronous Generator (PMSG from its integer model. The PMSG was employing a shaft sensor for the speed sensing and control. But this sensor would increase the hardware complexity as well as the cost of the system. Hence we have developed a Fractional order Nonlinear adaptive control method for speed and current tracking of the PMSG. The objective of an adaptive controller is to first define a virtual control state and force it to become a stabilizing function in accordance with a corresponding error dynamics. In order to study the Lyapunov exponents of the fractional order controller, we proposed a new method which would remove the complexity of finding the sign of the Lyapunov first derivative. The Fractional order control scheme is implemented in LabVIEW for simulation results. The simulation results indicated that the estimated rotor position and speed correspond to their actual values well. Keywords: Chaos suppression, Fractional order systems, Permanent magnet synchronous generator, Speed and current control, Lyapunov stability

  5. CRMP5 regulates generation and survival of newborn neurons in olfactory and hippocampal neurogenic areas of the adult mouse brain.

    Directory of Open Access Journals (Sweden)

    Alexandra Veyrac

    Full Text Available The Collapsin Response Mediator Proteins (CRMPS are highly expressed in the developing brain, and in adult brain areas that retain neurogenesis, ie: the olfactory bulb (OB and the dentate gyrus (DG. During brain development, CRMPs are essentially involved in signaling of axon guidance and neurite outgrowth, but their functions in the adult brain remain largely unknown. CRMP5 has been initially identified as the target of auto-antibodies involved in paraneoplasic neurological diseases and further implicated in a neurite outgrowth inhibition mediated by tubulin binding. Interestingly, CRMP5 is also highly expressed in adult brain neurogenic areas where its functions have not yet been elucidated. Here we observed in both neurogenic areas of the adult mouse brain that CRMP5 was present in proliferating and post-mitotic neuroblasts, while they migrate and differentiate into mature neurons. In CRMP5(-/- mice, the lack of CRMP5 resulted in a significant increase of proliferation and neurogenesis, but also in an excess of apoptotic death of granule cells in the OB and DG. These findings provide the first evidence that CRMP5 is involved in the generation and survival of newly generated neurons in areas of the adult brain with a high level of activity-dependent neuronal plasticity.

  6. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells.

    Science.gov (United States)

    Zhao, Jinming; Minami, Yoshinori; Etling, Emily; Coleman, John M; Lauder, Sarah N; Tyrrell, Victoria; Aldrovandi, Maceler; O'Donnell, Valerie; Claesson, Hans-Erik; Kagan, Valerian; Wenzel, Sally

    2017-12-01

    Type 2-associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase-1 (15LO1) is induced by the type 2 cytokine IL-13 in human airway epithelial cells (HAECs) in vitro and is increased in fresh asthmatic HAECs ex vivo. 15LO1 generates a variety of products, including 15-hydroxyeicosatetraenoic acid (15-HETE), 15-HETE-phosphatidylethanolamine (15-HETE-PE), and 13-hydroxyoctadecadienoic acid (13-HODE). In this study, we investigated the 15LO1 metabolite profile at baseline and after IL-13 treatment, as well as its influence on goblet cell differentiation in HAECs. Primary HAECs obtained from bronchial brushings of asthmatic and healthy subjects were cultured under air-liquid interface culture supplemented with arachidonic acid and linoleic acid (10 μM each) and exposed to IL-13 for 7 days. Short interfering RNA transfection and 15LO1 inhibition were applied to suppress 15LO1 expression and activity. IL-13 stimulation induced expression of 15LO1 and preferentially generated 15-HETE-PE in vitro, both of which persisted after removal of IL-13. 15LO1 inhibition (by short interfering RNA and chemical inhibitor) decreased IL-13-induced forkhead box protein A3 (FOXA3) expression and enhanced FOXA2 expression. These changes were associated with reductions in both mucin 5AC and periostin. Exogenous 15-HETE-PE stimulation (alone) recapitulated IL-13-induced FOXA3, mucin 5AC, and periostin expression. The results of this study confirm the central importance of 15LO1 and its primary product, 15-HETE-PE, for epithelial cell remodeling in HAECs.

  7. 76 FR 71468 - Defense Federal Acquisition Regulation Supplement: Accelerate Small Business Payments (DFARS Case...

    Science.gov (United States)

    2011-11-18

    ... all small business concerns. In combination with the change to the regulations, DoD immediately began... Federal Acquisition Regulation Supplement: Accelerate Small Business Payments (DFARS Case 2011-D008... Regulation Supplement to accelerate payments to all small business concerns. DATES: Effective Date: November...

  8. CXCL12-mediated feedback from granule neurons regulates generation and positioning of new neurons in the dentate gyrus.

    Science.gov (United States)

    Abe, Philipp; Wüst, Hannah M; Arnold, Sebastian J; van de Pavert, Serge A; Stumm, Ralf

    2018-03-14

    Adult hippocampal neurogenesis is implicated in learning and memory processing. It is tightly controlled at several levels including progenitor proliferation as well as migration, differentiation and integration of new neurons. Hippocampal progenitors and immature neurons reside in the subgranular zone (SGZ) and are equipped with the CXCL12-receptor CXCR4 which contributes to defining the SGZ as neurogenic niche. The atypical CXCL12-receptor CXCR7 functions primarily by sequestering extracellular CXCL12 but whether CXCR7 is involved in adult neurogenesis has not been assessed. We report that granule neurons (GN) upregulate CXCL12 and CXCR7 during dentate gyrus maturation in the second postnatal week. To test whether GN-derived CXCL12 regulates neurogenesis and if neuronal CXCR7 receptors influence this process, we conditionally deleted Cxcl12 and Cxcr7 from the granule cell layer. Cxcl12 deletion resulted in lower numbers, increased dispersion and abnormal dendritic growth of immature GN and reduced neurogenesis. Cxcr7 ablation caused an increase in progenitor proliferation and progenitor numbers and reduced dispersion of immature GN. Thus, we provide a new mechanism where CXCL12-signals from GN prevent dispersion and support maturation of newborn GN. CXCR7 receptors of GN modulate the CXCL12-mediated feedback from GN to the neurogenic niche. © 2018 Wiley Periodicals, Inc.

  9. A molecular toolbox for rapid generation of viral vectors to up- or down-regulate in vivo neuronal gene expression

    Directory of Open Access Journals (Sweden)

    Melanie D. White

    2011-07-01

    Full Text Available We introduce a molecular toolbox for manipulation of neuronal gene expression in vivo. The toolbox includes promoters, ion channels, optogenetic tools, fluorescent proteins and intronic artificial microRNAs. The components are easily assembled into adeno-associated virus (AAV or lentivirus vectors using recombination cloning. We demonstrate assembly of toolbox components into lentivirus and AAV vectors and use these vectors for in vivo expression of inwardly rectifying potassium channels (Kir2.1, Kir3.1 and Kir3.2 and an artificial microRNA targeted against the ion channel HCN1 (HCN1 miR. We show that AAV assembled to express HCN1 miR produces efficacious and specific in vivo knockdown of HCN1 channels. Comparison of in vivo viral transduction using HCN1 miR with mice containing a germ line deletion of HCN1 reveals similar physiological phenotypes in cerebellar Purkinje cells. The easy assembly and re-usability of the toolbox components, together with the ability to up- or down-regulate neuronal gene expression in vivo, may be useful for applications in many areas of neuroscience.

  10. Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.

    Directory of Open Access Journals (Sweden)

    Francesca Grespi

    2011-03-01

    Full Text Available Different bacteria-derived systems for regulatable gene expression have been developed for the use in mammalian cells and some were also successfully adopted for in vivo use in vertebrate model organisms. However, certain limitations apply to most of these systems, including leakiness of transgene expression, inefficient transgene silencing or activation, as well as limited tissue accessibility of transgene-inducers or their unfavourable pharmacokinetics. In this study, we evaluated the suitability of the lac-operon/lac-repressor (lacO/lacI system for the regulation of the well-established Vav-gene promoter that allows inducible transgene expression in different haematopoietic lineages in mice. Using the fluorescence marker protein Venus as a reporter, we observed that the lacO/lacI system could be amended to modulate transgene-expression in haematopoietic cells. However, reporter expression was not uniform and the lacO elements introduced into the Vav-gene promoter only conferred limited repression and reversion of lacI-mediated gene silencing after administration of IPTG. Although further optimization of the system is required, the lacO-modified version of the Vav-gene promoter may be adopted as a tool where low basal gene-expression and limited transient induction of protein expression are desired, e.g. for the activation of oncogenes or transgenes that act in a dominant-negative manner.

  11. Financial Management, DoD's Liability for Aircraft Disposal Can Be Estimated

    National Research Council Canada - National Science Library

    1997-01-01

    DOD has not yet implemented the federal accounting standard that requires recognizing and reporting liabilities such as those associated with aircraft disposal, nor has it provided guidance to the military services...

  12. Best Practices. An Integrated Portfolio Management Approach to Weapon System Investments Could Improve DOD's Acquisition Outcomes

    National Research Council Canada - National Science Library

    2007-01-01

    .... Specifically, GAO compared DOD's processes for investing in weapon systems to the best practices that successful commercial companies use to achieve a balanced mix of new products, and identified...

  13. United States Transportation Command Compliance with DoD Policy on the Use of Commercial Sealift

    National Research Council Canada - National Science Library

    Jolliffe, Richard B; Mehlman, Benjamin A; Lippolis, Susan J; Avers, Marc E; Brake, Chrispian M; Lyons, Amber M; Alvarez Torres, Zorayma; Groubert, Christopher S; Milner, Jillisa H

    2007-01-01

    .... The overall objective of the audit was to determine whether USTRANSCOM was complying with DoD policies in the use of commercial transport during wartime and whether those policies provide optimal...

  14. Implementation of DoD Public Key Infrastructure Policy and Procedures

    National Research Council Canada - National Science Library

    2001-01-01

    Introduction. Federal agencies, including DoD, are increasingly using the World Wide Web and other Internet-based applications to provide on-line public access to information and services as well as to improve...

  15. Guidelines for Using OAR Concepts in a DoD Product Line Acquisition Context

    National Research Council Canada - National Science Library

    Bergey, John

    2000-01-01

    Many DoD organizations are considering product line initiatives as a means of overcoming the issues of quality, cost and schedule inherent in a "one-at-a-time" system development or acquisition paradigm...

  16. DOD SCHOOLS: Additional Reporting Could Improve Accountability for Academic Achievement of Students with Dyslexia

    National Research Council Canada - National Science Library

    Ashby, Cornelia

    2007-01-01

    DOD provides both online and classroom-based professional development to teachers who work with students who struggle to read, and it used 2004-to-2006 funds designated for professional development...

  17. Financial Management: Analysis of DoD's First Biennial Financial Management Improvement Plan

    National Research Council Canada - National Science Library

    1999-01-01

    ...). The plan is to be submitted not later than September 30 of each even-numbered year and is to address all aspects of financial management within DOD, including the finance systems, accounting systems...

  18. Business Systems Modernization: DOD Needs to Fully Define Policies and Procedures for Institutionally Managing Investments

    National Research Council Canada - National Science Library

    Hite, Randolph C; Doherty, Neil; Fraser, Nalani; Glover, Nancy; Holland, Michael; Lakhmani, Neelaxi; Mai, Jacqueline; Paul, Sabine; Tandon, Niti; Stavros-Turner, Jennifer

    2007-01-01

    ... (IT) business system investment management. To support GAO's legislative mandate to review DoD's efforts, GAO assessed whether the department's corporate investment management approach comports with relevant federal guidance...

  19. The Pentagon and Global Development: Making Sense of the DoD's Expanding Role

    National Research Council Canada - National Science Library

    Patrick, Stewart; Brown, Kaysie

    2007-01-01

    ...). The Pentagon now accounts for over 20 percent of U.S. official development assistance (ODA). DoD also has expanded its provision of non-ODA assistance, including training and equipping of foreign military forces in fragile states...

  20. 77 FR 43506 - DoD Unclassified Controlled Nuclear Information (UCNI)

    Science.gov (United States)

    2012-07-25

    ... Department of Defense published a proposed rule on April 25, 2011 (76 FR 22849-22854). Comments from two... preclude its reconstruction. DoD UCNI in electronic form shall be deleted and also removed from any desktop...

  1. Deficiencies in FY 1998 DOD Financial Statements and Progress Toward Improved Financial Reporting

    National Research Council Canada - National Science Library

    Lane, F

    1999-01-01

    The audit objectives were to identify and summarize the major deficiencies that prevented favorable audit opinions on the FY 1998 DoD financial statements and to identify the actions taken or planned...

  2. Major Deficiencies Preventing Favorable Audit Opinions on the FY 1997 DoD Financial Statements

    National Research Council Canada - National Science Library

    Lane, F

    1998-01-01

    The audit objective was to identify and summarize the major deficiencies that prevented favorable audit opinions on the FY 1997 DoD Financial Statements, and to identify the actions taken or under way...

  3. Inpatient Data Supporting the DOD Military Retirement Health Benefits Liability Estimate

    National Research Council Canada - National Science Library

    Lane, F

    2000-01-01

    .... Military retirement health benefits are post-retirement benefits that DoD provides to military retirees and other eligible beneficiaries through the Civilian Health and Medical Program of the Uniformed Services (Purchased Care...

  4. Estimating DoD Transportation Spending: Analyses of Contract and Payment Transactions

    National Research Council Canada - National Science Library

    Moore, Nancy Y; Chenoweth, Mary E; Reardon, Elaine; Grammich, Clifford A; Bullock, Arthur M; Mele, Judith D; Kofner, Aaron; Unger, Eric J

    2007-01-01

    .... This analysis of combined individual contracting action report (DD350) and PowerTrack (PT) data indicates that DoD has additional opportunities to leverage transportation spending, particularly where it uses tenders to purchase transportation services...

  5. Financial Management: DoD Payroll Withholding Data for FY 2000

    National Research Council Canada - National Science Library

    2002-01-01

    We performed this audit in response to the Chief Financial Officers Act of 1990, as amended by the Federal Financial Management Act of 1994, which requires DoD and other Government agencies to prepare...

  6. Financial Management: DoD Process for Reporting Contingent Legal Liabilities

    National Research Council Canada - National Science Library

    Granetto, Paul J; Marsh, Patricia A; Peek, Marvin L; Brittingham, Scott S; Baidridge, Denise E; Egu, Charles O; Schenck, Kristy M; Adams, Carl L; Reiser, Cheri L

    2006-01-01

    Personnel within the Office of the Secretary of Defense, other DoD Components responsible for preparing the annual financial statements, and legal counsel who provide legal representations regarding...

  7. Data Supporting the Environmental Liability Line Item on the FY 1999 DoD Financial Statements

    National Research Council Canada - National Science Library

    2000-01-01

    We performed this audit in response to the Chief Financial Officers Act of 1990, as amended by the Federal Financial Management Act of 1994, which requires DoD and other Government agencies to prepare...

  8. Assessment of the DoD Biennial Financial Management Improvement Plan

    National Research Council Canada - National Science Library

    1999-01-01

    Objectives. This evaluation was conducted pursuant to the responsibility of the Inspector General, DoD, under the Federal Financial Management Improvement Act of 1996 to assess the progress made toward...

  9. Applying Insights from Transaction Cost Economics (TCE) to Improve DoD Cost Estimation

    National Research Council Canada - National Science Library

    Angelis, Diana I; Dillard, John; Franck, Raymond; Melese, Francois

    2007-01-01

    The purpose of this report is to explore the possibility of improving DoD cost estimation methods by including explanatory variables that capture the coordination and motivation problems associated with the program...

  10. The Federal Trust Doctrine: What Does It Mean for DoD?

    National Research Council Canada - National Science Library

    2004-01-01

    Policy Overview: DoD will meet its responsibleness to the tribes, recognize tribal sovereignty, consult before taking action, manage its lands consistent with the protection of tribal lands resources and traditional cultural properties...

  11. CONTRACT MANAGEMENT: No DOD Proposal to Improve Contract Service Costs Reporting

    National Research Council Canada - National Science Library

    2001-01-01

    ... were being improperly justified and classified and accounting systems used to track expenditures were inadequate. In view of these concerns, the Congress requires us to provide an annual assessment of DOD actions to address reporting problems.

  12. Critical Success Factors and Their Application to DOD Weapon System Acquisition

    National Research Council Canada - National Science Library

    Harris, Chad M

    2006-01-01

    .... The purpose of this project was to investigate and provide an overview of issues within the DoD acquisition system and provide information to assist program managers in dealing with some of the challenges they face...

  13. Transforming US Overseas Military Presence: Evidence and Options for DoD. Volume I: Main Report

    National Research Council Canada - National Science Library

    Atwell, Robert

    2002-01-01

    This study is intended to provide senior DoD and US government decision- makers with a compendium of the best available evidence concerning how alternative US presence postures are likely to affect...

  14. FY 2006 DoD Purchases Made Through the National Institutes of Health

    National Research Council Canada - National Science Library

    Jolliffe, Richard B; Burton, Bruce A; McKinney, Terry L; Seger, John A; Faller, Phillip M; Goodykoontz, David P; Principe, Jennifer M; Biggs, Courtney V; Kohut, Jonathan; McIsaac, Marcie A

    2007-01-01

    ...) Electronic Commodities Store III (ECS III) contracts or NIH contracting personnel made purchases on behalf of DoD using the NIH Chief Information Officer-Solutions and Partners 2 Innovations (CIO-SP2i) contracts...

  15. Critical Success Factors and Their Application to DOD Weapon System Acquisition

    National Research Council Canada - National Science Library

    Harris, Chad M

    2006-01-01

    .... The goal of this project was to identify Critical Success Factors and determine if they could be applied to DoD acquisition programs in order to improve the acquisition process and provide program...

  16. Defense Infrastructure: Continuing Challenges in Managing DOD Lodging Programs as Army Moves to Privatize Its Program

    National Research Council Canada - National Science Library

    Holman, Barry W; Kennedy, Michael; Dickey, Claudia; Lenane, Kate; Sarapu, Leslie; Silvers, Julie; Weissman, Cheryl

    2006-01-01

    The Department of Defense (DoD) transient lodging programs were established to provide quality temporary facilities for authorized personnel, and to reduce travel costs through lower rates than commercial hotels...

  17. Planning for Diversity: Options and Recommendations for DoD Leaders

    National Research Council Canada - National Science Library

    Lim, Nelson; Cho, Michelle; Curry, Kimberly

    2008-01-01

    .... For the strategic plan to be effective, DoD leaders must define "diversity" and explain how they intend to measure progress toward greater diversity and how they will hold themselves and others...

  18. DOD Controls Over Resources Used to Account for Missing U.S. Personnel

    National Research Council Canada - National Science Library

    1997-01-01

    We are providing this report for your information and use. This evaluation responds to two congressional requests to investigate allegations of DoD negligence in accounting for resources used to achieve full accounting for U.S...

  19. The Impact of e-Business on DoD Acquisition Processes

    National Research Council Canada - National Science Library

    Kerber, Ronald

    2002-01-01

    .... The Terms of Reference (TOR) for the study requested that the Task Force "review the DoD's current implementation status of e-commerce tools and make any appropriate recommendations that enhance this opportunity for cost...

  20. Reporting of the FY 1999 Military Retirement Health Benefits Liability in the DOD Financial Statements

    National Research Council Canada - National Science Library

    2000-01-01

    ... annual audited financial statements. The FY 1999 DoD Agency-Wide financial statements included the financial statements of a reporting entity entitled "Other Defense Organizations-General Funds...

  1. Space exploration initiative (SEI) logistics support lessons from the DoD

    Science.gov (United States)

    Cox, John R.; McCoy, Walbert G.; Jenkins, Terence

    Proven and innovative logistics management approaches and techniques used for developing and supporting DoD and Strategic Defense Initiative Office (SDIO) systems are described on the basis of input from DoD to the SEI Synthesis Group; SDIO-developed logistics initiatives, innovative tools, and methodologies; and logistics planning support provided to the NASA/Johnson Planet Surface System Office. The approach is tailored for lunar/Martian surface operations, and provides guidelines for the development and management of a crucial element of the SEI logistics support program. A case study is presented which shows how incorporation of DoD's proven and innovative logistics management approach, tools, and techniques can substantially benefit early logistics planning for SEI, while also implementing many of DoD's recommendations for SEI.

  2. DOD TRAVEL IMPROPER PAYMENTS: Fiscal Year 2006 Reporting Was Incomplete and Planned Improvement Efforts Face Challenges

    National Research Council Canada - National Science Library

    WIlliams, McCoy

    2007-01-01

    ... was incomplete because it understated the full extent of travel improper payments. The DOD travel payment data used to assess the program s risk of significant improper payments only included payments processed by the Defense Travel System (DTS...

  3. AEROSPACE NESHAP GUIDANCE: PAINTING AND DEPAINTING ALTERNATIVES FOR SELECTED DOD OPERATIONS

    Science.gov (United States)

    This project was sponsored by the DOD's Strategic Environmental Research and Development program (SERDP) and conducted by the EPA's Clean Processes and Products Branch at the NRMRL. In support of SERDP's objective of developing environmental solutions that improve mission readine...

  4. Data Supporting the DOD Environmental Line Item Liability on the FY 1998 Financial Statements

    National Research Council Canada - National Science Library

    1999-01-01

    ... consolidated financial statements. This audit supports our audit of the FY 1998 DoD Agency wide financial statements and future audits of financial statements that are required by the Chief Financial Officers Act of 1990, as amended...

  5. Compilation Process for the DOD Consolidated Financial Statements for FY 1997

    National Research Council Canada - National Science Library

    1998-01-01

    ... statements beginning in FY 1997. Office of Management and Budget and DoD Guidance on Form and Content of Audited Financial Statements requires that amounts reported in the footnotes be consistent with amounts reported as line items...

  6. Health Care: Report on the DoD Patient Movement System

    National Research Council Canada - National Science Library

    Joseph, Michael A; Tonkovic, Timothy J; Hanlon, Robert J; Martin, Anna P; Hatten, Danny O; Hubbell, Mary A; Ali, Tamika S; Noell, Monica L

    2005-01-01

    The primary mission of the DoD patient movement system is to safely transport U.S. military casualties from a combat zone to fixed medical treatment facilities and field hospitals in or out of the combat theater...

  7. The Effects of A-76 Cost Comparisons on DoD Civilian Education and Training

    National Research Council Canada - National Science Library

    Keating, Edward G; Levy, Dina G; Moini, Joy S; Gates, Susan M; Leuschner, Kristin; Riley, Candice; Kaganoff, Tessa; Augustine, Catherine H

    2006-01-01

    ... (Executive Office of the President, May 29, 2003), under which government employees compete with contractors over who will perform a commercial activity, and there are plans for considerably more A-76 comparisons in the DoD...

  8. Year 2000 Certification of Mission-Critical DoD Information Technology Systems

    National Research Council Canada - National Science Library

    1998-01-01

    Our objective was to determine whether the year 2000 certification process is adequate to ensure that mission critical DoD information technology systems will continue to operate properly after the year 2000...

  9. Summary of Security Control Audits of DoD Finance and Accounting Systems

    National Research Council Canada - National Science Library

    2001-01-01

    .... The Act requires DoD to develop a cost-effective security control program that continually assesses risk, is tested and evaluated periodically, and is approved by the Director, Office of Management and Budget...

  10. Workshop Introducing Innovation and Risk: Implications of Transforming the Culture of DoD

    National Research Council Canada - National Science Library

    Johnson, Edgar

    2004-01-01

    On 21-22 October 2003, the Institute for Defense Analyses hosted a workshop on issues facing DoD in transforming its culture from the today's Industrial Age to one more prepared for and accepting of the Information Age...

  11. Managing Sensitive Information: DOD Can More Effectively Reduce the Risk of Classification Errors

    National Research Council Canada - National Science Library

    D'Agostino, Davi M; Borseth, Ann; Fenton, Mattias; Hatton, Adam; Hills, Barbara; Keefer, David; Mayfield, David; Reid, Jim; Richardson, Terry; Schwartz, Marc

    2006-01-01

    .... While some DoD components and their subordinate commands appear to manage effective programs, GAO identified weaknesses in others in the areas of classification management training, self-inspections...

  12. Financial Management: DoD Process for Reporting Contingent Legal Liabilities

    National Research Council Canada - National Science Library

    Granetto, Paul J; Marsh, Patricia A; Peek, Marvin L; Brittingham, Scott S; Baidridge, Denise E; Egu, Charles O; Schenck, Kristy M; Adams, Carl L; Reiser, Cheri L

    2006-01-01

    ... contingent liabilities should read this report. It identifies areas where DoD and its Components have not fully complied with Federal financial accounting standards and are not consistent in computing and disclosing contingent legal liabilities...

  13. Report on the Audit of DoD Immunity From State Taxation

    National Research Council Canada - National Science Library

    1991-01-01

    .... We also determined if sales taxes were being applied to direct purchases by DoD, and if contracting officers were ensuring that contactors were taking full advantage of existing immunity from state taxes...

  14. CONTINGENCY CONTRACTING: DOD, State, and USAID Contracts and Contractor Personnel in Iraq and Afghanistan

    National Research Council Canada - National Science Library

    Hutton, John; Ayers, Johana R; Berkholtz, Jessica M; Brandon, E; Culley, Brendan S; James, Jr., Art; McMillen, Lisa A; McSween, Jean; Thornton, Karen

    2008-01-01

    DOD, State, and USAID reported that they obligated at least $33.9 billion during fiscal year 2007 and the first half of fiscal year 2008 on 56,925 contracts with performance in either Iraq or Afghanistan...

  15. DoD Business Mission Area Service-Oriented Architecture to Support Business Transformation

    National Research Council Canada - National Science Library

    Wisnosky, Dennis E; Feldshteyn, Dimitry; Mancuso, Wil; Gough, Al E; Riutort, Eric J; Strassman, Paul

    2008-01-01

    ... 1.4 million people and holding approximately $1.4 trillion in assets. IT spending for business support activities in the DoD BMA-funds to operate, maintain, and modernize business systems-comprise...

  16. WHERE HAVE OUR PEOPLE GONE SEQUESTRATION’S EFFECTS ON DOD HUMAN CAPITAL

    Science.gov (United States)

    2017-06-01

    AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY WHERE HAVE OUR PEOPLE GONE? SEQUESTRATION’S EFFECTS ON DOD HUMAN CAPITAL by...reduction combined with decreased funding allocated for training is having hazardous effects on the human capital of the DOD. The quantitative data...cuts that had a direct impact on the human capital , or knowledge and abilities of the people that complete the mission. One of the major implications

  17. DOD Advertising: Better Coordination, Performance Measurement, and Oversight Needed to Help Meet Recruitment Goals

    Science.gov (United States)

    2016-05-01

    follow when carrying out other types of advertising. For example, the components may contract to carry out advertising at music concerts or... festivals . These events are similar in nature to sporting events as they may also allow for the inclusion of tickets other premium items in advertising...as music concerts, other event advertising, and digital advertising. We provided a draft of this report to DOD for comment. In written comments, DOD

  18. Applying Best Business Practices from Corporate Performance Management to DoD

    Science.gov (United States)

    2013-01-01

    leading or governing large, complex corporations and are experienced in creating reliable solutions to complex management issues guided by best business ...recommendations and effective solutions aimed at improving DoD. Defense Business Board Corporate Performance Management REPORT FY13-03 Task...Group 1 Applying Best Business Practices from Corporate Performance Management to DoD TASK The Deputy Secretary of Defense (DEPSECDEF

  19. An Analysis of Internal Controls for DoD Contract Management

    Science.gov (United States)

    2015-12-01

    alternative control activities to reduce the risk of fraud ( COSO , 2013; GAO, 2014). Also, the Office of Management and Budget (OMB), which contains an...force. Since 1992, the Government Accountability Office (GAO) has identified contract management within the DOD as an area for high risk in fraud...force. Since 1992, the Government Accountability Office (GAO) has identified contract management within the DOD as an area for high risk in fraud

  20. DOD Civilian and Contractor Workforces: Additional Cost Savings Data and Efficiencies Plan are Needed

    Science.gov (United States)

    2016-10-01

    Enterprise-wide Contractor Manpower Reporting Application (ECMRA) across all its components, and which will continue to improve reporting of...costs: Not applicable yes (estimated) no (estimated) Source: GAO analysis of DOD’s February 2016 status report | GAO-17-128 aNumber of...and interviewed DOD officials. What GAO Recommends GAO previously recommended that DOD fully address ongoing section 955 requirements, such as

  1. DOD Renewable Energy Projects: Improved Guidance Needed for Analyzing and Documenting Costs and Benefits

    Science.gov (United States)

    2016-09-01

    other locations. • Consumption . To the extent economically feasible and technically practicable, not less than 7.5 percent of electrical energy...Policy Act of 2005, to count toward the consumption goal, DOD must possess renewable energy credits for electricity it consumes.18 Executive Order...difficulties inherent in predicting electricity prices sometimes decades into the future.62 However, DOD did not consistently describe the

  2. (Department of Defense Office of Inspector General (DoD OIG)) Fiscal Year 2017 Oversight Plan

    Science.gov (United States)

    2016-12-01

    Transparency Act of 2014. Specifically, for a statistically valid sample of spending data submitted by the DoD, assess the completeness, timeliness...facilities did not appropriately transfer funds to the U.S. Treasury for 114 delinquent accounts, valued at $13.4 million, of the 125 accounts the...the DoD Office of Inspector General Delinquent Medical Service Account Audits This is a summary report to identify systemic problems regarding

  3. Developing a Comprehensive Approach Could Help DOD Better Manage National Security Risks in the Supply Chain

    Science.gov (United States)

    2016-02-01

    supply chains for rare earths.20 According to Industrial Analysis Center officials, only 10 percent of surveys sent to prime contractors for 79...the Supply Chain Report to Congressional Committees February 2016 GAO-16-161 United States Government Accountability Office United...Developing a Comprehensive Approach Could Help DOD Better Manage National Security Risks in the Supply Chain Why GAO Did This Study DOD depends on

  4. Defense Additive Manufacturing: DOD Needs to Systematically Track Department-wide 3D Printing Efforts

    Science.gov (United States)

    2015-10-01

    the chair of the group, while the teams each have some level of activity in additive manufacturing , it is not identified as one of the teams. Page...DEFENSE ADDITIVE MANUFACTURING DOD Needs to Systematically Track Department-wide 3D Printing Efforts Report to...2015 to 00-00-2015 4. TITLE AND SUBTITLE Defense Additive Manufacturing : DOD Needs to Systematically Track Department-wide 3D Printing Efforts 5a

  5. Defense Acquisition Workforce: DOD Has Opportunities to Further Enhance Use and Management of Development Fund

    Science.gov (United States)

    2017-03-01

    engineering, and business . To ensure that DOD has the right people with the right skills to meet future needs, we recommended that DOD complete competency...years to address attrition in contracting and to hire engineers in new areas such as cybersecurity . • The Air Force’s March 2016 DAWDF guidance...planning.23 For example, in fiscal year 2015, the Defense Acquisition University, the Navy, and the Army each provided cybersecurity -related training

  6. Engineering Change Orders and their Impact on DoD Acquisition Contracts

    Science.gov (United States)

    2017-03-23

    Air Force Institute of Technology AFIT Scholar Theses and Dissertations 3-23-2017 Engineering Change Orders and their Impact on DoD Acquisition...administrator of AFIT Scholar. For more information, please contact richard.mansfield@afit.edu. Recommended Citation Cordell, Ian S., " Engineering Change... ENGINEERING CHANGE ORDERS AND THEIR IMPACT ON DOD ACQUISITION CONTRACTS THESIS Ian S. Cordell, Captain, USAF AFIT-ENC

  7. Financial Management: DOD Needs to Clarify Its General Gift Fund Policies to Provide for Effective Oversight

    Science.gov (United States)

    2009-05-27

    Representatives Subject: Financial Management: DOD Needs to Clarify Its General Gift Fund Policies to Provide for Effective Oversight From fiscal...year 2005 through fiscal year 2008, the military services received about $295 million in monetary and nonmonetary gifts from individuals and...organizations wishing to donate gifts to the Department of Defense (DOD).1 Section 2601(a) of Title 10, U.S. Code is a long-standing authority under which

  8. Military Personnel: DOD Has Processes for Operating and Managing Its Sexual Assault Incident Database

    Science.gov (United States)

    2017-01-01

    MILITARY PERSONNEL DOD Has Processes for Operating and Managing Its Sexual Assault Incident Database Report to...to DSAID’s system speed and ease of use; interfaces with MCIO databases ; utility as a case management tool; and users’ ability to query data and... Managing Its Sexual Assault Incident Database What GAO Found As of October 2013, the Department of Defense’s (DOD) Defense Sexual Assault Incident

  9. DoD Actions Were Not Adequate to Reduce Improper Travel Payments

    Science.gov (United States)

    2016-03-10

    vouchers in near real time and identifies duplicate or incorrect payments. DoD Components developed corrective actions that did not include steps to...causes of improper payments. In addition, many of the payment errors were not preventable through real - time or post-payment automated validation checks...H 1 0 , 2 0 1 6 Report No. DODIG-2016-060 DoD Actions Were Not Adequate to Reduce Improper Travel Payments Mission Our mission is to provide

  10. Regulating the Regulator

    Energy Technology Data Exchange (ETDEWEB)

    1992-08-26

    The article reports on a challenge to the UK electricity regulator to defend his record by the Coalition for Fair Electricity Regulation (COFFER). The challenge centres on whether the obligation for the regional electric companies (REC) to purchase power from the cheapest source is being enforced. This is related to the wider issue of whether the REC's support of combined-cycle gas turbine (CCGT) is economic. COFFER considers that uneconomic gas-fired power plants are being allowed to displace economic coal-fired stations. Aspects discussed include the background to the dispute and the costs of CCGT and coal fired power generation. 1 fig., 1 tab.

  11. Degree-of-Freedom Strengthened Cascade Array for DOD-DOA Estimation in MIMO Array Systems.

    Science.gov (United States)

    Yao, Bobin; Dong, Zhi; Zhang, Weile; Wang, Wei; Wu, Qisheng

    2018-05-14

    In spatial spectrum estimation, difference co-array can provide extra degrees-of-freedom (DOFs) for promoting parameter identifiability and parameter estimation accuracy. For the sake of acquiring as more DOFs as possible with a given number of physical sensors, we herein design a novel sensor array geometry named cascade array. This structure is generated by systematically connecting a uniform linear array (ULA) and a non-uniform linear array, and can provide more DOFs than some exist array structures but less than the upper-bound indicated by minimum redundant array (MRA). We further apply this cascade array into multiple input multiple output (MIMO) array systems, and propose a novel joint direction of departure (DOD) and direction of arrival (DOA) estimation algorithm, which is based on a reduced-dimensional weighted subspace fitting technique. The algorithm is angle auto-paired and computationally efficient. Theoretical analysis and numerical simulations prove the advantages and effectiveness of the proposed array structure and the related algorithm.

  12. A change of course: The importance to DoD of international standards for electronic commerce

    Science.gov (United States)

    Payne, Judith E.

    1991-12-01

    The U.S. Department of Defense (DoD) is committed to using electronic commerce in the future with the over 300,000 vendors interested in doing business with DoD. Electronic commerce will move DoD from a paper-based world to one based on electronic transactions enabled by the exchange of formatted, electronic messages referred to as electronic data interchange (EDI). With electronic commerce, DoD plans to reduce costs, increase effectiveness, and make it easier for vendors to deal with DoD. Benefits from electronic commerce are enhanced when many businesses use the same standards for EDI messages themselves and their transmission. The fewer standards used, the less time and resources must be spent translating messages and agreeing on how to use different standards. To enhance benefits and smooth the transition to electronic commerce for itself and its vendors, DoD has chosen to use the widely accepted American National Standards Institute (ANSI) X12 standards for EDI messages, coupled with international standards for delivering messages and organizing addresses. In the past 18 months, EDI standards sponsored by a United Nations body and serving the same purpose as ANSI X12 message standards have begun to gain wider acceptance internationally.

  13. Resveratrol strongly enhances the retinoic acid-induced superoxide generating activity via up-regulation of gp91-phox gene expression in U937 cells.

    Science.gov (United States)

    Kikuchi, Hidehiko; Mimuro, Hitomi; Kuribayashi, Futoshi

    2018-01-01

    The membrane bound cytochrome b 558 composed of gp91-phox and p22-phox proteins, and cytosolic proteins p40-, p47-and p67-phox are important components of superoxide (O 2 - )-generating system in phagocytes. Here, we describe that resveratrol, a pleiotropic phytochemical belonging to the stilbenoids, dramatically activates the O 2 - -generating system during retinoic acid (RA)-induced differentiation of human monoblastic leukemia U937 cells to macrophage-like cells. When U937 cells were cultured in the presence of RA and resveratrol, the O 2 - -generating activity increased more than 5-fold compared with that in the absence of the latter. Semiquantitative RT-PCR showed that co-treatment with RA and resveratrol strongly enhanced transcription of the gp91-phox compared with those of the RA-treatment only. On the other hand, immunoblot analysis revealed that co-treatment with RA and resveratrol caused remarkable accumulation of protein levels of gp91-phox (to 4-fold), p22-phox (to 5-fold) and p47-phox (to 4-fold) compared with those of the RA-treatment alone. In addition, ChIP assay suggested that resveratrol participates in enhancing the gene expression of gp91-phox via promoting acetylation of Lys-9 residues and Lys-14 residues of histone H3 within chromatin around the promoter regions of the gene. These results suggested that resveratrol strongly enhances the RA-induced O 2 - -generating activity via up-regulation of gp91-phox gene expression in U937 cells. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Cost Benefit Analysis: Closed-Cell Polyurethane Foam Use in DOD Forward-Deployed Structures and As An Alternative Building Material to Reduce Operational Fuel Demand and Associated Costs

    Science.gov (United States)

    2015-06-01

    value and/or consideration operational energy has within the requirements and acquisition management systems . 2. Past DOD Operational Energy Policy...Key Performance Parameter (KPP)” (Bohnwagner 2013a, p. 1) to ensure energy demand of weapons systems are optimized to manage the expected fuel burden...and/or capabilities (e.g., landfill or incinerator ), thus making them only quantifiable when location and corresponding environmental regulations are

  15. IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations.

    Science.gov (United States)

    Xu, Fenghuang; Yi, Junzhu; Wang, Zhuoya; Hu, Yejia; Han, Chunlei; Xue, Qun; Zhang, Xueguang; Luan, Xiying

    2017-08-01

    Interleukin 27 (IL-27) regulates T cell function and is involved in inflammation. It has been reported that human placenta-derived mesenchymal stromal cells (hPMSCs) can inhibit T cell responses and attenuate inflammation reactions. However, it is unclear whether IL-27 can regulate hPMSC function. Here, we examined the effects of IL-27 upon adherence, migration, and proliferation as well as the immunomodulatory effects of hPMSCs. The results show that IL-27 receptor α chain (IL-27Rα) is expressed in hPMSCs. IL-27 at 30 ng/ml inhibited hPMSC adherence and proliferation, while the migration of hPMSCs was promoted with IL-27 at doses of 20 or 30 ng/ml, as determined with use of real-time cell analysis (RTCA). Moreover, IL-27 promoted regulatory effects of hPMSCs through enhancing Th2 and suppressing Th1 subset generation from activated T cells in human peripheral blood. IL-27 also enhanced the ability of hPMSCs to secrete IL-10 from CD4 + T cells through increased expression levels of the programmed death ligand 1 (PDL1) in hPMSCs via the Janus kinase (JAK)/signal transducer and activator of transcription 1 (STAT1) signaling pathway. In conclusion, IL-27 has significant modulatory effects on adherence, proliferation, and migration of hPMSCs. IL-27 increased PDL1 expression levels in hPMSCs via the JAK/STAT1 pathway, which then enhanced the regulatory effects of hPMSCs upon Th1 and Th2 cell generations and IL-10 secretion from CD4 + T cells.

  16. Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloides

    Science.gov (United States)

    Nicolas, Francisco Esteban; Moxon, Simon; de Haro, Juan P.; Calo, Silvia; Grigoriev, Igor V.; Torres-Martínez, Santiago; Moulton, Vincent; Ruiz-Vázquez, Rosa M.; Dalmay, Tamas

    2010-01-01

    Endogenous short RNAs (esRNAs) play diverse roles in eukaryotes and usually are produced from double-stranded RNA (dsRNA) by Dicer. esRNAs are grouped into different classes based on biogenesis and function but not all classes are present in all three eukaryotic kingdoms. The esRNA register of fungi is poorly described compared to other eukaryotes and it is not clear what esRNA classes are present in this kingdom and whether they regulate the expression of protein coding genes. However, evidence that some dicer mutant fungi display altered phenotypes suggests that esRNAs play an important role in fungi. Here, we show that the basal fungus Mucor circinelloides produces new classes of esRNAs that map to exons and regulate the expression of many protein coding genes. The largest class of these exonic-siRNAs (ex-siRNAs) are generated by RNA-dependent RNA Polymerase 1 (RdRP1) and dicer-like 2 (DCL2) and target the mRNAs of protein coding genes from which they were produced. Our results expand the range of esRNAs in eukaryotes and reveal a new role for esRNAs in fungi. PMID:20427422

  17. Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloides

    Energy Technology Data Exchange (ETDEWEB)

    Grigoriev, Igor; Nicolas, Francisco; Moxon, Simon; Haro, Juan de; Calo, Silvia; Torres-Martinez, Santiago; Moulton, Vincent; Ruiz-Vazquez, Rosa; Dalmay, Tamas

    2011-09-01

    Endogenous short RNAs (esRNAs) play diverse roles in eukaryotes and usually are produced from double-stranded RNA (dsRNA) by Dicer. esRNAs are grouped into different classes based on biogenesis and function but not all classes are present in all three eukaryotic kingdoms. The esRNA register of fungi is poorly described compared to other eukaryotes and it is not clear what esRNA classes are present in this kingdom and whether they regulate the expression of protein coding genes. However, evidence that some dicer mutant fungi display altered phenotypes suggests that esRNAs play an important role in fungi. Here, we show that the basal fungus Mucor circinelloides produces new classes of esRNAs that map to exons and regulate the expression of many protein coding genes. The largest class of these exonic-siRNAs (ex-siRNAs) are generated by RNA-dependent RNA Polymerase 1 (RdRP1) and dicer-like 2 (DCL2) and target the mRNAs of protein coding genes from which they were produced. Our results expand the range of esRNAs in eukaryotes and reveal a new role for esRNAs in fungi

  18. Evaluation of handling and reuse approaches for the waste generated from MEA-based CO2 capture with the consideration of regulations in the UAE.

    Science.gov (United States)

    Nurrokhmah, Laila; Mezher, Toufic; Abu-Zahra, Mohammad R M

    2013-01-01

    A waste slip-stream is generated from the reclaiming process of monoethanolamine (MEA) based Post-Combustion Capture (PCC). It mainly consists of MEA itself, ammonium, heat-stable salts (HSS), carbamate polymers, and water. In this study, the waste quantity and nature are characterized for Fluor's Econamine FGSM coal-fired CO2 capture base case. Waste management options, including reuse, recycling, treatment, and disposal, are investigated due to the need for a more environmentally sound handling. Regulations, economic potential, and associated costs are also evaluated. The technical, economic, and regulation assessment suggests waste reuse for NOx scrubbing. Moreover, a high thermal condition is deemed as an effective technique for waste destruction, leading to considerations of waste recycling into a coal burner or incineration. As a means of treatment, three secondary-biological processes covering Complete-Mix Activated Sludge (CMAS), oxidation ditch, and trickling filter are designed to meet the wastewater standards in the United Arab Emirates (UAE). From the economic point of view, the value of waste as a NOx scrubbing agent is 6,561,600-7,348,992 USD/year. The secondary-biological treatment cost is 0.017-0.02 USD/ton of CO2, while the cost of an on-site incinerator is 0.031 USD/ton of CO2 captured. In conclusion, secondary biological treatment is found to be the most economical option.

  19. An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio.

    Science.gov (United States)

    Lin, Wei-Hsiang; He, Miaomiao; Fan, Yuen Ngan; Baines, Richard A

    2018-05-02

    Despite availability of a diverse range of anti-epileptic drugs (AEDs), only about two-thirds of epilepsy patients respond well to drug treatment. Thus, novel targets are required to catalyse the design of next-generation AEDs. Manipulation of neuron firing-rate homoeostasis, through enhancing Pumilio (Pum) activity, has been shown to be potently anticonvulsant in Drosophila. In this study, we performed a genome-wide RNAi screen in S2R + cells, using a luciferase-based dPum activity reporter and identified 1166 genes involved in dPum regulation. Of these genes, we focused on 699 genes that, on knock-down, potentiate dPum activity/expression. Of this subgroup, 101 genes are activity-dependent based on comparison with genes previously identified as activity-dependent by RNA-sequencing. Functional cluster analysis shows these genes are enriched in pathways involved in DNA damage, regulation of cell cycle and proteasomal protein catabolism. To test for anticonvulsant activity, we utilised an RNA-interference approach in vivo. RNAi-mediated knockdown showed that 57/101 genes (61%) are sufficient to significantly reduce seizure duration in the characterized seizure mutant, para bss . We further show that chemical inhibitors of protein products of some of the genes targeted are similarly anticonvulsant. Finally, to establish whether the anticonvulsant activity of identified compounds results from increased dpum transcription, we performed a luciferase-based assay to monitor dpum promoter activity. Third instar larvae exposed to sodium fluoride, gemcitabine, metformin, bestatin, WP1066 or valproic acid all showed increased dpum promoter activity. Thus, this study validates Pum as a favourable target for AED design and, moreover, identifies a number of lead compounds capable of increasing the expression of this homeostatic regulator.

  20. A free radical-generating system regulates AβPP metabolism/processing: involvement of the ubiquitin/proteasome and autophagy/lysosome pathways.

    Science.gov (United States)

    Recuero, María; Munive, Victor A; Sastre, Isabel; Aldudo, Jesús; Valdivieso, Fernando; Bullido, María J

    2013-01-01

    Oxidative stress is an early event in the pathogenesis of Alzheimer's disease (AD). We previously reported that, in SK-N-MC cells, the xanthine/xanthine oxidase (X-XOD) free radical generating system regulates the metabolism/processing of the amyloid-β protein precursor (AβPP). Oxidative stress alters the two main cellular proteolytic machineries, the ubiquitin/proteasome (UPS) and the autophagy/lysosome systems, and recent studies have established connections between the malfunctioning of these and the pathogenesis of AD. The aim of the present work was to examine the involvement of these proteolytic systems in the regulation of AβPP metabolism by X-XOD. The proteasome inhibitor MG132 was found to accelerate the metabolism/processing of AβPP promoted by X-XOD because it significantly enhances the secretion of α-secretase-cleaved soluble AβPP and also the levels of both carboxy-terminal fragments (CTFs) produced by α- and β-secretase. Further, MG132 modulated the intracellular accumulation of holo-AβPP and/or AβPP CTFs. This indicates that the X-XOD modulation of AβPP metabolism/processing involves the UPS pathway. With respect to the autophagy/lysosome pathway, the AβPP processing and intracellular location patterns induced by X-XOD treatment closely resembled those produced by the lysosome inhibitor ammonium chloride. The present results suggest that the regulation of AβPP metabolism/processing by mild oxidative stress requires UPS activity with a simultaneous reduction in that of the autophagy/lysosome system.

  1. The analysis of the influence of the current regulation on the parameters of the MHD-genarator Faraday's type and on the mutual work of the generator and electric power network

    International Nuclear Information System (INIS)

    Dabrowski, K.

    1988-07-01

    This paper contains: comparison of the influence of the I=const. and U=const. regulation on the gasdynamic characteristics of the MHD-generator Faraday's type with segmented electrodes, comparison of the influence of the I=const. and U=const. regulation on choice of the compressor which causes the gas flow in the MHD generator, analysis of the influence of the I=const. regulation on the mutual work of the MHD-generator and electric power network in nonsteady states caused by the stagnation temperature drop at the MHD-duct inlet. In the work was assumed: one dimensional mathematical model of the MHD-generator, mathematical model of the inverter was constructed by means of the ''zero-one'' model of the thyristor, multichannel, synchronous control system of the inverters, inflexible electric power network. 12 refs., 11 figs., 2 tabs. (author)

  2. DoD Needs to Improve Screening and Access Controls for General Public Tenants Leasing Housing on Military Installations (REDACTED)

    Science.gov (United States)

    2016-04-01

    helps enhance service members’ quality of life by improving the condition of military-owned housing faster and more economically than traditional...DEPARTMENT OF THE ARMY SUBJECT: DoD Needs to Improve Screening and Access Controls for General Public Tenants Leasing Housing on Military...public tenants who leased DoD privatized housing before granting those tenants unescorted access to military installations. In addition, DoD officials

  3. CAC on a MAC: setting up a DOD Common Access Card reader on the Macintosh OS X operating system

    OpenAIRE

    Hopfner, Phil

    2006-01-01

    The Naval Postgraduate School, along with many other Department of Defense (DOD) organizations, utilizes the ActivCard USB Common Access Card (CAC) readers. The CAC readers in conjunction with the user's Smart Card enables access to DOD PKI-enabled websites and allows the user to send signed and encrypted email utilizing the DOD Public Key Infrastructure (PKI). Microsoft Windows systems utilize the ActivCard Gold middleware software to enable CAC reader functionality. This software packag...

  4. [Standardization and regulation of the rate of the superoxide-generating adrenaline autoxidation reaction used for evaluation of pro/antioxidant properties of various materials].

    Science.gov (United States)

    Sirota, T V

    2016-11-01

    The superoxide-generating reaction of adrenaline autoxidation is widely used for determination of the activity of superoxide dismutase and pro/antioxidant properties of various materials. There are two variants of the spectrophotometric registration of the products of this reaction. The first is based on registration of adrenochrome, as adrenaline autooxidation product at 347 nm; the second employs nitro blue tetrazolium (NBT) and registration of diformazan, a product of NBT reduction at 560 nm. In the present work, recommendations for the standardization of the reaction rate in both variants have been proposed. The main approach consists in the use of the pharmaceutical form of 0.1% adrenaline hydrochloride solution. Although each of two adrenaline preparations available in the Russian market has some features in kinetic behavior of its autooxidation; they are applicable in the superoxide generating system based on adrenaline autooxidation. Performing measurements at 560 nm, the reaction rate can be regulated by lowering the concentration of added adrenaline, whereas during spectrophotometric registration at 347 nm, this cannot be done. These features of adrenaline autoxidation may be due to the fact that the intrinsic multistage process of the conversion of adrenaline to adrenochrome, which is recorded at 347 nm, is coupled with the transition of electrons from adrenaline and intermediate products of its oxidation to oxygen, carbon dioxide, and carbonate bicarbonate ions, which is detected in the presence of added NBT.

  5. DOD Use of Commercial Wideband Satellite Communications Systems: How Much is Needed, and How Do We Get It?

    National Research Council Canada - National Science Library

    Hutchens, Robert

    2001-01-01

    ..., A key enabler to this end is sufficient wideband satellite communications connectivity DoD's organic wideband satellite communications capabilities are inadequate, so commercial services must be used...

  6. Defense Computers: DOD Y2K Functional End-to-End Testing Progress and Test Event Management

    National Research Council Canada - National Science Library

    1999-01-01

    ... (DOD) which relies on a complex and broad array of interconnected computer systems-including weapons, command and control, satellite, inventory management, transportation management, health, financial...

  7. DoD Cybersecurity Weakness as Reported in Audit Reports Issued From August 1, 2014, Through July 31, 2015 (REDACTED)

    Science.gov (United States)

    2015-09-25

    Protocol Version 6 ( IPv6 ). The Federal and DoD requirements were not completed because the DoD Chief Information Officer (CIO) and U.S. Cyber Command...had not made IPv6 a priority. Further, the DoD CIO did not have a current plan of action and milestones to advance DoD IPv6 migration efforts...According to the report, the continued use of IPv4 will delay the potential benefits of IPv6 , such as improved communication, warfighter mobility

  8. 78 FR 17176 - Federal Acquisition Regulation; Defense Base Act

    Science.gov (United States)

    2013-03-20

    ... Regulation; Defense Base Act AGENCIES: Department of Defense (DoD), General Services Administration (GSA... the Defense Base Act. DATES: Interested parties should submit written comments to the Regulatory... Act as extended by the Defense Base Act. II. Discussion and Analysis The Defense Base Act of 1941...

  9. 76 FR 39242 - Federal Acquisition Regulation; TINA Interest Calculations

    Science.gov (United States)

    2011-07-05

    ... pricing data. This rule replaces the term ``simple interest'' as the requirement for calculating interest...-AL73 Federal Acquisition Regulation; TINA Interest Calculations AGENCIES: Department of Defense (DoD... interest calculations be applied to Government overpayments as a result of defective cost or pricing data...

  10. 76 FR 48776 - Federal Acquisition Regulation; Documenting Contractor Performance; Correction

    Science.gov (United States)

    2011-08-09

    ... Regulation; Documenting Contractor Performance; Correction AGENCY: Department of Defense (DoD), General... published in the Federal Register of June 28, 2011, regarding the proposed rule for Documenting Contractor... published in the Federal Register of June 28, 2011, regarding the proposed rule for Documenting Contractor...

  11. DOD Electronic Commerce (EC)/Electronic Data Interchange (EDI) in contracting report

    Science.gov (United States)

    1993-12-01

    Use of Electronic Commerce (EC)/Electronic Data Interchange (EDI) to support Department of Defense (DoD) procurement processes has been under consideration for some time. A 1988 Deputy Secretary of Defense memo calls for maximum use of EDI, based on 10 years of DoD EDI investigation and experiments. In 1990, Defense Management Review Decision 941 stated, 'The strategic goal of DoD's current efforts is to provide the department with the capability to initiate, conduct, and maintain its external business related transactions and internal logistics, contracting, and financial activities without requiring the use of hard copy media.' The EC in Contracting PAT membership reflected a broad cross section of Military Services and Defense Agencies working on a full-time basis for 60 days. The diversity of the EC in Contracting PAT ensured that the needs and concerns of all DoD components were addressed during the creation of the report. The resultant plan, therefore, represents a comprehensive approach for implementing EC throughout the DoD.

  12. 75 FR 71560 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS...

    Science.gov (United States)

    2010-11-24

    ... also asked what allowance is provided for contractors with accounting software that does not... RIN 0750-AG46 Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting... Regulation Supplement (DFARS) to address DoD Cost and Software Data Reporting system requirements for Major...

  13. 75 FR 18041 - Defense Federal Acquisition Regulation Supplement; Minimizing Use of Hexavalent Chromium (DFARS...

    Science.gov (United States)

    2010-04-08

    ...-AG35 Defense Federal Acquisition Regulation Supplement; Minimizing Use of Hexavalent Chromium (DFARS... Regulation Supplement (DFARS) to address requirements for minimizing the use of hexavalent chromium in... of items containing hexavalent chromium under DoD contracts unless an exception applies. DATES...

  14. 75 FR 60261 - Federal Acquisition Regulation; Award-Fee Language Revision

    Science.gov (United States)

    2010-09-29

    ...-AL42 Federal Acquisition Regulation; Award-Fee Language Revision AGENCIES: Department of Defense (DoD...: Final rule. SUMMARY: The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) have adopted as final, with changes, the interim rule amending the Federal Acquisition...

  15. 78 FR 5451 - Federal Acquisition Regulation; Submission for OMB Review; Permits, Authorities, or Franchises

    Science.gov (United States)

    2013-01-25

    ...; Submission for OMB Review; Permits, Authorities, or Franchises AGENCIES: Department of Defense (DOD), General... approved information collection requirement concerning permits, authorities, or franchises for regulated..., Permits, Authorities, or Franchises, by any of the following methods: Regulations.gov : http://www...

  16. 77 FR 69442 - Federal Acquisition Regulation; Information Collection; Economic Price Adjustment

    Science.gov (United States)

    2012-11-19

    ...; Information Collection; Economic Price Adjustment AGENCIES: Department of Defense (DOD), General Services... economic price adjustment. Public comments are particularly invited on: Whether this collection of..., Economic Price Adjustment by any of the following methods: Regulations.gov : http://www.regulations.gov...

  17. 75 FR 52650 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items (2008-D011)

    Science.gov (United States)

    2010-08-27

    ...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Interim rule; delay in... rule that amended the Defense Federal Acquisition Regulation Supplement (DFARS) to implement sections... comments on the interim rule were located, which had not been addressed in finalization of the interim rule...

  18. 75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

    Science.gov (United States)

    2010-10-25

    ... Accounting Service or Missile Defense Agency. (2) For DoD, the authority to acknowledge receipt or reject... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 219 and 252 [DFARS Case 2009-D002] Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting...

  19. 75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-03

    ..., et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition and... Regulation Supplement; Business Systems--Definition and Administration (DFARS Case 2009-D038) AGENCY: Defense.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  20. 76 FR 71465 - Defense Federal Acquisition Regulation Supplement: Management of Manufacturing Risk in Major...

    Science.gov (United States)

    2011-11-18

    ... Government procurement. Mary Overstreet, Editor, Defense Acquisition Regulations System. Interim Rule Adopted... Federal Acquisition Regulation Supplement: Management of Manufacturing Risk in Major Defense Acquisition...). ACTION: Final rule. SUMMARY: DoD is adopting as final, without change, an interim rule amending the...

  1. 75 FR 3178 - Defense Federal Acquisition Regulation Supplement; Lead System Integrators

    Science.gov (United States)

    2010-01-20

    ... Government procurement. Amy G. Williams, Editor, Defense Acquisition Regulations System. 0 Accordingly, the..., without change, an interim rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to... limitations on the award of new contracts for lead system integrator functions in the acquisition of major DoD...

  2. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

    Science.gov (United States)

    2010-04-21

    ... suppliers; and (3) foster the establishment of long-term business relationships between protege firms and... technology. The Office of Management and Budget (OMB) has approved this information collection for use...

  3. Regulating Services as Measures of Ecological Resilience on DoD Lands

    Science.gov (United States)

    2015-11-23

    the services (e.g. wildlife habitat provision and recreation opportunities) that the installations provided and compared those to the potential...US Census Bureau, US Bureau of Labor Statistics Census tract National 2010 Demand on RS Sewage discharge points NC Rural Economic Development

  4. Acquisition Regulations and Offshore Software Development: Implications for Cybersecurity of DOD Networks

    Science.gov (United States)

    2013-02-14

    analysis and manipulation ( SCAM ). This is because source code is the only precise description of the behavior of the system.47 The DSB Task Force on...A, K, Krishnan M, Mukhopadhyay T. Contracts in Offshore Software Development: An Empirical Analysis. Management Science [serial online ]. December

  5. Nuclear regulation

    International Nuclear Information System (INIS)

    1990-04-01

    Because of an accidental release in 1986 of low-level waste stored at the Wright-Patterson Air Force Base, Ohio, several individuals inhaled small amounts of a radioactive substance. GAO examined the Nuclear Regulatory Commission's oversight of the Department of Defense's use, handling, and disposal of radioactive material and found that no comprehensive DOD waste disposal program exists and none of the three services knows the full extent of its low-level radioactive waste disposal problems. Throughout the 1980s, the Army and the Air Force had, on occasion, been banned from disposal sites for failing to comply with federal and state requirements. By December 1992, two of the three sites now used by DOD to disposed of waste will close, and only a limited number of new sites may be available for several years. In the interim, DID will pay substantial surcharges to dispose of waste. After January 1993, DOD will have to comply with disposal requirements for as many as 16 sites or store waste on-site pending the availability of new sites. This report discusses how GAO believes DOD needs to take full advantage of the time between now and January 1993 to establish a low-level radioactive waste disposal program. DOD also needs to work with other federal agencies, compacts, and states to determine the feasibility of dedicating a portion of one or more disposal sites for the government's use

  6. Global War on Terrorism: DOD Needs to Take Action to Encourage Fiscal Discipline and Optimize the Use of Tools Intended to Improve GWOT Cost Reporting

    National Research Council Canada - National Science Library

    Pickup, Sharon; Williams, McCoy

    2007-01-01

    Our analysis of DOD s fiscal year 2007 reported obligations through June 2007 shows that, at that time, DOD s reported GWOT obligations were almost equal to all GWOT obligations for fiscal year 2006...

  7. Mutual enhancement of IL-2 and IL-7 on DNA vaccine immunogenicity mainly involves regulations on their receptor expression and receptor-expressing lymphocyte generation.

    Science.gov (United States)

    Zhang, Yonghong; Liang, Shuang; Li, Xiujin; Wang, Liyue; Zhang, Jianlou; Xu, Jian; Huo, Shanshan; Cao, Xuebin; Zhong, Zhenyu; Zhong, Fei

    2015-07-09

    Our previous study showed that IL-2 and IL-7 could mutually enhance the immunogenicity of canine parvovirus VP2 DNA vaccine, although the underlying mechanism remained unknown. Here, we used the OVA gene as a DNA vaccine in a mouse model to test their enhancement on DNA vaccine immunogenicity and to explore the molecular mechanism. Results showed that both IL-2 and IL-7 genes significantly increased the immunogenicity of OVA DNA vaccine in mice. Co-administration of IL-2 and IL-7 genes with OVA DNA significantly increased OVA-specific antibody titers, T cell proliferation and IFN-γ production compared with IL-2 or IL-7 alone, confirming that IL-2 and IL-7 mutually enhanced DNA vaccine immunogenicity. Mechanistically, we have shown that IL-2 significantly stimulated generation of IL-7 receptor-expressing lymphocytes, and that IL-7 significantly induced IL-2 receptor expression. These results contribute to an explanation of the mechanism of the mutual effects of IL-2 and IL-7 on enhancing DNA vaccine immunogenicity and provided a basis for further investigation on their mutual effects on adjuvant activity and immune regulation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Dendritic Kv3.3 potassium channels in cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes.

    Science.gov (United States)

    Zagha, Edward; Manita, Satoshi; Ross, William N; Rudy, Bernardo

    2010-06-01

    Purkinje cell dendrites are excitable structures with intrinsic and synaptic conductances contributing to the generation and propagation of electrical activity. Voltage-gated potassium channel subunit Kv3.3 is expressed in the distal dendrites of Purkinje cells. However, the functional relevance of this dendritic distribution is not understood. Moreover, mutations in Kv3.3 cause movement disorders in mice and cerebellar atrophy and ataxia in humans, emphasizing the importance of understanding the role of these channels. In this study, we explore functional implications of this dendritic channel expression and compare Purkinje cell dendritic excitability in wild-type and Kv3.3 knockout mice. We demonstrate enhanced excitability of Purkinje cell dendrites in Kv3.3 knockout mice, despite normal resting membrane properties. Combined data from local application pharmacology, voltage clamp analysis of ionic currents, and assessment of dendritic Ca(2+) spike threshold in Purkinje cells suggest a role for Kv3.3 channels in opposing Ca(2+) spike initiation. To study the physiological relevance of altered dendritic excitability, we measured [Ca(2+)](i) changes throughout the dendritic tree in response to climbing fiber activation. Ca(2+) signals were specifically enhanced in distal dendrites of Kv3.3 knockout Purkinje cells, suggesting a role for dendritic Kv3.3 channels in regulating propagation of electrical activity and Ca(2+) influx in distal dendrites. These findings characterize unique roles of Kv3.3 channels in dendrites, with implications for synaptic integration, plasticity, and human disease.

  9. 78 FR 9890 - DoD Medicare-Eligible Retiree Health Care Board of Actuaries; Notice of Federal Advisory...

    Science.gov (United States)

    2013-02-12

    ... Actuaries; Notice of Federal Advisory Committee Meeting AGENCY: DoD. ACTION: Meeting notice. SUMMARY: Under... Retiree Health Care Board of Actuaries will take place. DATES: Friday, August 2, 2013, from 10:00 a.m. to... Activity, DoD Office of the Actuary, 4800 Mark Center Drive, STE 06J25-01, Alexandria, VA 22350-4000. Phone...

  10. 75 FR 6360 - Federal Advisory Committee; DoD Medicare-Eligible Retiree Health Care Board of Actuaries

    Science.gov (United States)

    2010-02-09

    ... Retiree Health Care Board of Actuaries AGENCY: Department of Defense (DoD). ACTION: Meeting notice... Actuaries will meet on August 18, 2010. Subject to the availability of space, the meeting is open to the...: Margot Kaplan at the DoD Office of the Actuary, 4040 N. Fairfax Drive, Suite 308, Arlington, VA 22203...

  11. Pressures on DoD’s Budget Over the Next Decade

    Science.gov (United States)

    2016-11-16

    pay raises then equaled ECI for 2011 through 2013 – In the last three years (2014–2016) basic pay raise was below the ECI ■ DoD estimates that...National Civilians Provider Other Government Agencies (4.2) Working Capital Funds (37.6) Private Sector (87.7) DoD Civilians (53.6) Classified (14.8) WCF...E Outline • Fiscal Situation • Implications of Budget Control Act • Internal Pressures on DoD’s Budget 2C O N G R E S S I O N A L B U D G E

  12. DOD Commissaries and Exchanges: Plan and Additional Information Needed on Cost Savings and Metrics for DOD Efforts to Achieve Budget Neutrality

    Science.gov (United States)

    2016-11-14

    three mandated benchmarks for customer satisfaction , quality of products, and patron savings but does not define specific metrics for each of the...benchmarks. For example, DOD has not defined customer satisfaction relative to maintaining a “high level” of satisfaction or determined what results would...quality of products, and patron savings, the report does not define specific metrics to measure each of the benchmarks. Customer Satisfaction Surveys

  13. Multimedia courseware in an open-systems environment: a DoD strategy

    Science.gov (United States)

    Welsch, Lawrence A.

    1991-03-01

    The federal government is about to invest billions of dollars to develop multimedia training materials for delivery on computer-based interactive training systems. Acquisition of a variety of computers and peripheral devices hosting various operating systems and suites of authoring system software will be necessary to facilitate the development of this courseware. There is no single source that will satisfy all needs. Although high-performance, low-cost interactive training hardware is available, the products have proprietary software interfaces. Because the interfaces are proprietary, expensive reprogramming is usually required to adapt such software products to other platforms. This costly reprogramming could be eliminated by adopting standard software interfaces. DoD's Portable Courseware Project (PORTCO) is typical of projects worldwide that require standard software interfaces. This paper articulates the strategy whereby PORTCO leverages the open systems movement and the new realities of information technology. These realities encompass changes in the pace at which new technology becomes available, changes in organizational goals and philosophy, new roles of vendors and users, changes in the procurement process, and acceleration toward open system environments. The PORTCO strategy is applicable to all projects and systems that require open systems to achieve mission objectives. The federal goal is to facilitate the creation of an environment in which high quality portable courseware is available as commercial off-the-shelf products and is competitively supplied by a variety of vendors. In order to achieve this goal a system architecture incorporating standards to meet the users' needs must be established. The Request for Architecture (RFA) developed cooperatively by DoD and the National Institute of Standards and Technology (NIST) will generate the PORTCO systems architecture. This architecture must freely integrate the courseware and authoring software from

  14. 32 CFR 310.37 - DoD training programs.

    Science.gov (United States)

    2010-07-01

    ...) considerations that they shall take into account when making management decisions regarding operational programs... include information regarding information privacy laws, regulations, policies and procedures governing the Department's collection, maintenance, use, or dissemination of personal information. The objective is to...

  15. Application of Artificial Intelligence to the DoD Corporate Information Management (CIM) Program

    Science.gov (United States)

    1992-04-01

    problem of balancing the investments of the corporation between several possible assets; buildings, machine tools, training, R&D and "information...and quality of worklife /learning/empowerment. For the moment the driving factor for the DoD has been identified as cost reduction, however it is clear

  16. 32 CFR Appendix A to Part 223 - Procedures for Identifying and Controlling DoD UCNI

    Science.gov (United States)

    2010-07-01

    ... security measures, including security plans, procedures, and equipment, for the physical protection of DoD... stand-alone personal computers, or shared-logic work processing systems, if protection from unauthorized... and security by increasing significantly the likelihood of the illegal production of nuclear weapons...

  17. 75 FR 60397 - DoD Freedom of Information Act (FOIA) Program

    Science.gov (United States)

    2010-09-30

    ...-354, ``Regulatory Flexibility Act'' (5 U.S.C. 601) It has been certified that 32 CFR part 285 is not subject to the Regulatory Flexibility Act (5 U.S.C. 601) because it would not, if promulgated, have a..., the DoD Field Activities, and all other organizational entities in the Department of Defense...

  18. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 3

    Science.gov (United States)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  19. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 1

    Science.gov (United States)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA conference on Fibrous Composites in structural Design. Presentations were made in the following areas of composite structural design: perspectives in composites; design methodology; design applications; design criteria; supporting technology; damage tolerance; and manufacturing.

  20. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 2

    Science.gov (United States)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  1. DOD Future Energy Resources. Proceedings of Workshops Held at the National Defense University

    National Research Council Canada - National Science Library

    2003-01-01

    .... In response to concerns about U.S. and global depletion of cheap petroleum resources and the particular impact of this on future DOD energy resource needs, a series of workshops were held during 2002 and 2003 at National Defense University...

  2. 5 CFR 9901.223 - Appeal to DoD for review of classification decisions.

    Science.gov (United States)

    2010-01-01

    ... state specific points of disagreement with the current classification. The employee may also include a....223 Appeal to DoD for review of classification decisions. (a) Employee representation. An employee may... an appeal. A management official may disallow an employee's representative when— (1) An individual's...

  3. 77 FR 74279 - Agency Information Collection (VA/DOD Joint Disability Evaluation Board Claim): Activity under...

    Science.gov (United States)

    2012-12-13

    ... Joint Disability Evaluation Board Claim): Activity under OMB Review AGENCY: Veterans Benefits... . Please refer to ``OMB Control No. 2900-0704.'' SUPPLEMENTARY INFORMATION: Title: VA/DOD Joint Disability Evaluation Board Claim, VA Form 21- 0819. OMB Control Number: 2900-0704. Type of Review: Extension of a...

  4. 77 FR 14955 - DoD Information Assurance Scholarship Program (IASP)

    Science.gov (United States)

    2012-03-14

    ... point of contact at each CAE, responsible for publicizing the DoD IASP to potential recruitment students... college or university to NSA. Centers of Academic Excellence in Information Assurance Education and... proposal, and all colleges and universities subsequently receiving grants must provide documentation on how...

  5. 32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false DoD Command Newspaper and Magazine Review System... OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. E Appendix E to Part 247—DoD Command Newspaper and Magazine Review...

  6. Military Personnel: Performance Measures Needed to Determine How Well DOD’s Credentialing Program Helps Servicemembers

    Science.gov (United States)

    2016-10-01

    MILITARY PERSONNEL Performance Measures Needed to Determine How Well DOD’s Credentialing Program Helps Servicemembers...Measures Needed to Determine How Well DOD’s Credentialing Program Helps Servicemembers What GAO Found The Department of Defense (DOD) has taken steps to...establish the statutorily required credentialing program, but it has not developed performance measures to gauge the program’s effectiveness

  7. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Soderquist, J.R.; Neri, L.M.; Bohon, H.L.

    1992-09-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA conference on Fibrous Composites in structural Design. Presentations were made in the following areas of composite structural design: perspectives in composites; design methodology; design applications; design criteria; supporting technology; damage tolerance; and manufacturing. Separate abstracts have been indexed into the database for articles from this report.

  8. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Soderquist, J.R.; Neri, L.M.; Bohon, H.L.

    1992-09-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  9. Defense Logistics: DOD Needs to Take Additional Actions to Address Challenges in Supply Chain Management

    Science.gov (United States)

    2011-07-01

    Jack E. Edwa appendix III. t rds Director, Defense Capabilities and Managemen Page 36 GAO-11-569 Defense Logistics List of Committees...Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302... operations . DOD faces asset visibility challenges due, in part, to a lack of interoperability among information technology

  10. Defense Infrastructure: DOD Needs Clearer Guidance on Notifying Congress of Privately Financed Construction Projects

    Science.gov (United States)

    2017-01-01

    welfare, and recreation activities such as recreation centers; food , beverage , and entertainment programs; and recreational lodging. Private...fast food restaurants. Because these projects are not authorized and funded through the regular appropriations process for military construction...commissaries.8 These funds can be used for various specified purposes, including the construction of commissaries.9 DOD commissaries are managed by

  11. DOD Financial Management: Greater Visibility Needed to Better Assess Audit Readiness for Property, Plant, and Equipment

    Science.gov (United States)

    2016-05-01

    with U.S. generally accepted accounting principles and establish and maintain effective internal control over financial reporting and compliance with... Accountability Office Highlights of GAO-16-383, a report to congressional committees May 2016 DOD FINANCIAL MANAGEMENT Greater Visibility... Accounting Standards Advisory Board FIAR Financial Improvement and Audit Readiness IUS internal-use software NDAA National Defense Authorization Act

  12. Defense Budget: DOD Needs to Improve Reporting of Operation and Maintenance Base Obligations

    Science.gov (United States)

    2016-08-01

    10For additional information on DOD’s planning, programming, budgeting, and execution process, see GAO, DOD Service Acquisition ...check, or money order. Call for additional information. Connect with GAO on Facebook , Flickr, Twitter, and YouTube. Subscribe to our RSS Feeds or E

  13. Biodefense Research Supporting the DoD: A New Strategic Vision

    National Research Council Canada - National Science Library

    Martinez, Coleen K

    2007-01-01

    .... In the post-September 11, 2001 (9/11) environment, however, the scope of potential threats has increased immeasurably, relative funding for the DoD has decreased, urgency to field solutions has skyrocketed, the FDA has provided a way...

  14. Early Warning: Brought to you by the DoD Chem-Bio Defense Program

    Science.gov (United States)

    Security Robots Lasers RSS Feed Early Warning: Brought to you by the DoD Chem-Bio Defense Program help warfighters prevent, protect against, respond to or recover from chem-bio threats and effects . Hassell said he and his team don't monitor the world for chem-bio threats, they develop the tools that

  15. DOD Service Academies. Update on Extent of Sexual Harassment. Report to Congressional Requesters.

    Science.gov (United States)

    General Accounting Office, Washington, DC. National Security and International Affairs Div.

    This report provides an update on the nature and extent of sexual harassment at the three Department of Defense (DOD) service academies. It is based on a stratified random survey of 430 Military Academy cadets, 470 Naval Academy midshipmen, and 428 Air Force Academy cadets, which oversampled women to ensure that a statistically significant number…

  16. Suicide Risk by Military Occupation in the DoD Active Component Population

    Science.gov (United States)

    Trofimovich, Lily; Reger, Mark A.; Luxton, David D.; Oetjen-Gerdes, Lynne A.

    2013-01-01

    Suicide risk based on occupational cohorts within the U.S. military was investigated. Rates of suicide based on military occupational categories were computed for the Department of Defense (DoD) active component population between 2001 and 2010. The combined infantry, gun crews, and seamanship specialist group was at increased risk of suicide…

  17. Geological investigations and hydrogeologic model development in support of DoD and DOE environmental programs on Kirtland Air Force Base, New Mexico, U.S.A

    International Nuclear Information System (INIS)

    Gibson, J.D.; Pratt, G.; Davidson, H.; DeWitt, C.; Hitchcock, C.; Kelson, K.; Noller, J.; Sawyer, T.; Thomas, E.

    1994-01-01

    This paper presents results of preliminary geologic site characterization and hydrogeologic conceptual model development for the 250-km 2 Kirtland Air Force Base (KAFB) and associated lands in central New Mexico. The research, development, and other operational activities of the Department of Defense (DoD) and Department of Energy (DOE) on KAFB over the last 50 years have resulted in diverse hazardous, radioactive, and mixed-waste environmental concerns. Because multiple federal, state, and local agencies are responsible for administrating the involved lands and because of the nature of many U.S. environmental regulations, individual contaminated and potentially contaminated DoD and DOE environmental restoration (ER) sites on KAFB are commonly handled as distinct entities with little consideration for the cumulative environmental and health risk from all sites. A site-wide characterization program has been undertaken at Sandia National Laboratories/New Mexico (SNL/NM), under the auspices of the DOE, to construct a conceptual hydrogeologic model for the base. This conceptual model serves as the basis for placing each ER site into a broader context for evaluating background (i.e., non-contaminated) conditions and for modeling of possible contaminant pathways and travel-times. Regional and local hydrogeologic investigations from KAFB can be used as models for characterizing and evaluating other sites around the world where combined civilian and military environmental programs must work together to resolve environmental problems that may present health risks to workers and the general public

  18. Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

    Directory of Open Access Journals (Sweden)

    Shravan Babu Girada

    2017-10-01

    Conclusions: The findings provide the mechanism of endosomal cyclic AMP generation following GLP-1R activation. We identified the specific compartment that serves as an organizing center to generate endosomal cyclic AMP by internalized activated receptor complex.

  19. The Effect of Delayed-JOLs and Sentence Generation on Children's Monitoring Accuracy and Regulation of Idiom Study

    Science.gov (United States)

    van Loon, Mariëtte H.; de Bruin, Anique B. H.; van Gog, Tamara; van Merriënboer, Jeroen J. G.

    2013-01-01

    When studying verbal materials, both adults and children are often poor at accurately monitoring their level of learning and regulating their subsequent restudy of materials, which leads to suboptimal test performance. The present experiment investigated how monitoring accuracy and regulation of study could be improved when learning idiomatic…

  20. Future Health and Economic Impact of Comprehensive Tobacco Control in DoD: A Microsimulation Approach.

    Science.gov (United States)

    Yang, Wenya; Zou, Quan; Tan, Eleonora; Watkins, Lachlan; Beronja, Kaleigh; Hogan, Paul F; Elenberg, Kimberly

    2018-01-01

    Tobacco use is a major concern to the Military Health System of the Department of Defense (DoD). The 2011 DoD Health Related Behavior Survey reported that 24.5% of active duty personnel are current smokers, which is higher than the national estimate of 20.6% for the civilian population. Overall, it is estimated that tobacco use costs the DoD $1.6 billion a year through related medical care, increased hospitalization, and lost days of work, among others. This study evaluated future health outcomes of Tricare Prime beneficiaries aged 18-64 yr (N = 3.2 million, including active duty and retired military members and their dependents) and the potential economic impact of initiatives that DoD may take to further its effort to transform the military into a tobacco-free environment. Our analysis simulated the future smoking status, risk of developing 25 smoking-related diseases, and associated medical costs for each individual using a Markov Chain Monte Carlo microsimulation model. Data sources included Tricare administrative data, national data such as Centers for Disease Control and Prevention mortality data and National Cancer Institute's cancer registry data, as well as relative risks of diseases obtained from a literature review. We found that the prevalence of active smoking among the Tricare Prime population will decrease from about 24% in 2015 to 18% in 2020 under a status quo scenario. However, if a comprehensive tobacco control initiative that includes a 5% price increase, a tighter clean air policy, and an intensified media campaign were to be implemented between 2016 and 2020, the prevalence of smoking could further decrease to 16%. The near 2 percentage points reduction in smoking prevalence represents an additional 81,240 quitters and translates to a total lifetime medical cost savings (in 2016 present value) of $968 million, with 39% ($382 million) attributable to Tricare savings. A comprehensive tobacco control policy within the DoD could significantly

  1. The Role of the Department of Defense (DoD) in Solar Energy Research, Development and Diffusion

    National Research Council Canada - National Science Library

    Benham, Jr., William T; Cabral, III, Noel J

    2008-01-01

    ... for a national transformation toward a new energy future. This report examines the feasibility of niche solar energy applications and the methods that DoD might positively impact solar energy research, development and technology diffusion.

  2. Financial Management: Processing General Services Administration Rent Bills for DoD Customers in the National Capital Region

    National Research Council Canada - National Science Library

    Granetto, Paul

    2003-01-01

    .... The Washington Headquarters Services (WHS) is responsible for the oversight and management of administrative space occupied by DoD agencies and Military departments in the National Capital Region...

  3. Report of the Defense Science Board Task Force on Mission Impact of Foreign Influence on DoD Software

    National Research Council Canada - National Science Library

    2007-01-01

    The Defense Science Board (DSB) Task Force on Mission Impact of Foreign Influence on DoD Software examined areas in software security, security architecture, and risk mitigation and received briefings from industry, academia...

  4. Report of the Defense Science Board Task Force on DoD Energy Strategy, "More Fight - Less Fuel"

    National Research Council Canada - National Science Library

    2008-01-01

    ... opportunities to reduce DoD's energy demand, identify institutional obstacles to their implementation, and assess their potential commercial and security benefits to the nation Overview Based on its study...

  5. DOD Business Systems Modernization: Progress in Establishing Corporate Management Controls Needs to Be Replicated Within Military Departments

    National Research Council Canada - National Science Library

    Hite, Randolph C; Epps, Elena; Holland, Michael; Johnson, Tonia; Lakhmani, Neelaxi; LaPaze, Rebecca; Le, Anhe; Paintsil, Freda

    2008-01-01

    .... In particular, on March 14, 2008, DOD released a new version of its BEA and issued its annual report to congressional defense committees describing steps taken and planned relative to the act's...

  6. 2001 Quadrennial Defense Review: Mechanism for a DoD Human Resource Management Revolution in Business Affairs

    National Research Council Canada - National Science Library

    Rogers, Curtis

    2001-01-01

    .... Accepting the concept of a Revolution in Business Affairs (RBA) is DoD acknowledgment that over the last twenty years substantial advances in business management practices have been made by the private sector...

  7. Quick-Reaction Report on DoD Support for the 1996 Paralympics and Centennial Olympic Games

    National Research Council Canada - National Science Library

    Lane, F

    1996-01-01

    This audit report is the first in a series of reports that will be issued in response to a request from the Director, Office of Special Events regarding DoD support of the 1996 Olympic and Paralympic Games...

  8. Military Personnel: DOD's Predatory Lending Report Addressed Mandated Issues, but Support Is Limited for Some Findings and Recommendations

    National Research Council Canada - National Science Library

    Farrell, Brenda S

    2007-01-01

    ... (see the list of related GAO products at the end of this report). In conducting our review, we limited the scope of our work to the types of loans that DOD identified as being predatory in its mandated 2006 report...

  9. DOD Residential Proton Exchange Membrane (PEM) Fuel Cell Demonstration Program. Volume 2. Summary of Fiscal Year 2001-2003 Projects

    Science.gov (United States)

    2005-09-01

    produced many of the Beatles 1970s recordings. This facility was selected to host the UK PEM demonstration project from a selection of four potential sites...funded the Department of Defense (DOD) Residential PEM Demonstration Project to demonstrate domestically-produced, residential Proton Exchange Membrane...PEM) fuel cells at DOD Facilities. The objectives were to: (1) assess PEM fuel cells’ role in supporting sustainability at military installations

  10. Defense Civil Support: DOD Needs to Identify National Guards Cyber Capabilities and Address Challenges in Its Exercises

    Science.gov (United States)

    2016-09-01

    participated in exercises to support civil authorities in a cyber incident or to test the responses to simulated attacks on cyber infrastructure owned by...authorities or to test the response to simulated attacks on cyber infrastructure owned by civil authorities. Of these 9 exercises, DOD conducted 7...and a response to simulated cyber attacks on electric grid networks. According to a North American Electric Reliability Corporation official, DOD

  11. Defense Civil Support: DOD, HHS, and DHS Should Use Existing Coordination Mechanisms to Improve Their Pandemic Preparedness

    Science.gov (United States)

    2017-02-01

    documentation is not shared with a broad audience , HHS officials said that it is available to DOD stakeholders upon request, and as soon as it is approved...instructions to support incident relief efforts. • Alerts the NDMS FCCs to activate NDMS patient reception plans with a phased, regional approach and, when...patient reception areas, using available DOD transportation resources in coordination with the NDMS Medical Interagency Coordination Group

  12. DOD Task Force for Business and Stability Operations in Afghanistan: Review of Selected Expenditures Highlights Serious Management and Oversight Problems

    Science.gov (United States)

    2016-04-15

    execute projects and programs, but rather to advise DOD entities on ways to improve contracting processes and procedures. The memorandum establishing the...Task Force stated, “The Task Force will not be responsible for contracting, but will advise existing DoD contracting offices on improved...including the fact that the AGS did not appear to screen the trainees it nominated , resulting in the majority of the trainees being functionally

  13. Human Capital: Additional Actions Needed to Enhance DOD’s Efforts to Address Mental Health Care Stigma

    Science.gov (United States)

    2016-04-01

    Civilians (n=21) 6 5 8 2 h) Substance abuse (alcohol or drugs ) Servicemembers (n= 186) 43 53 82 8 Civilians (n=22) 9 8 4 1 Source: GAO | GAO...Efforts to Address Mental Health Care Stigma Why GAO Did This Study A 2010 DOD task force on suicide prevention concluded that stigma—the negative...Representatives A 2010 Department of Defense (DOD) Task Force on the Prevention of Suicide by Members of the Armed Forces concluded that

  14. DoD Cybersecurity Weaknesses as Reported in Audit Reports Issued From August 1, 2015 Through July 31, 2016 (REDACTED)

    Science.gov (United States)

    2016-12-13

    INFORMATION TECHNOLOGY , GOVERNMENT ACCOUNTABILITY OFFICE SUBJECT: DoD Cybersecurity Weaknesses as Reported in Audit Reports Issued From August...The Air Force Audit Agency recommended that the Air Force Reserve officials direct AFRC personnel to implement a standard process to ensure continued...those products and systems throughout the system development life cycle. The DoD audit community and the GAO reported configuration management

  15. Electronic Health Records: VAs Efforts Raise Concerns about Interoperability Goals and Measures, Duplication with DOD, and Future Plans

    Science.gov (United States)

    2016-07-13

    ELECTRONIC HEALTH RECORDS VA’s Efforts Raise Concerns about Interoperability Goals and Measures, Duplication with DOD...Agencies, Committee on Appropriations, U.S. Senate July 13, 2016 ELECTRONIC HEALTH RECORDS VA’s Efforts Raise Concerns about Interoperability Goals...initiatives with the Department of Defense (DOD) that were intended to advance the ability of the two departments to share electronic health records ,

  16. DoD Cardholders Used Their Government Travel Cards for Personal Use at Casinos and Adult Entertainment Establishments

    Science.gov (United States)

    2015-05-19

    GTCC: • transactions with no associated travel status in DTS; • automated teller machine (ATM) withdrawals that exceeded the overall Meal and...Defense Travel System or other DoD travel systems; 2. Automated teller machine withdrawals that exceed the overall meal and incidental expense...System or other DoD travel systems; • Automated teller machine withdrawals that exceed the overall meal and incidental expense amounts while in a travel

  17. Guidance for DoD Utilization of Host Nation Power

    Science.gov (United States)

    2015-10-28

    data)  The Honduran electric company,  Empresa  Nacional  de  Energia Electrica (ENEE) generates power and  operates the national transmission and...CDF  Cumulative Distribution Function  DoD  Department of Defense  ENEE  Empresa  Nacional  de  Energia Electrica  EUPW  Escalating Uniform Present Worth...generators with the fuel either purchased from the local  population or  transported  from remote fuel depots.  This incurs a significant cost for the

  18. The $100 Genome: Implications for the DoD

    Science.gov (United States)

    2010-12-15

    Human Microbiome. In some cases it may be useful to sequence metagenomic samples of the microbiomes that colonize the human gut. oral cavity or other...to "generate resources enabling the comprehensive characterization of human microbiota and analysis of its role in human health and disease". Such...extraordinary genetic diversity of the gut microbiome, it is expected that these organisms (which usually have the first chance to interact with orally

  19. Alterations in emotion generation and regulation neurocircuitry in depression and eating disorders: A comparative review of structural and functional neuroimaging studies.

    Science.gov (United States)

    Donofry, Shannon D; Roecklein, Kathryn A; Wildes, Jennifer E; Miller, Megan A; Erickson, Kirk I

    2016-09-01

    Major depression and eating disorders (EDs) are highly co-morbid and may share liability. Impaired emotion regulation may represent a common etiological or maintaining mechanism. Research has demonstrated that depressed individuals and individuals with EDs exhibit impaired emotion regulation, with these impairments being associated with changes in brain structure and function. The goal of this review was to evaluate findings from neuroimaging studies of depression and EDs to determine whether there are overlapping alterations in the brain regions known to be involved in emotion regulation, evidence of which would aid in the diagnosis and treatment of these conditions. Our review of the literature suggests that depression and EDs exhibit common structural and functional alterations in brain regions involved in emotion regulation, including the amygdala, ventral striatum and nucleus accumbens, anterior cingulate cortex, insula, and dorsolateral prefrontal cortex. We present preliminary support for a shared etiological mechanism. Future studies should consider manipulating emotion regulation in a sample of individuals with depression and EDs to better characterize abnormalities in these brain circuits. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. 78 FR 18342 - Federal Acquisition Regulation; Submission for OMB Review; Change Order Accounting

    Science.gov (United States)

    2013-03-26

    ...; Submission for OMB Review; Change Order Accounting AGENCY: Department of Defense (DOD), General Services... requirement concerning change order accounting. A notice was published in the Federal Register at 77 FR 51804... Collection 9000- 0026, Change Order Accounting, by any of the following methods: Regulations.gov : http://www...

  1. 77 FR 51804 - Federal Acquisition Regulation; Information Collection; Change Order Accounting

    Science.gov (United States)

    2012-08-27

    ...; Information Collection; Change Order Accounting AGENCY: Department of Defense (DOD), General Services... requirement concerning change order accounting. Public comments are particularly invited on: Whether this... 9000- 0026, Change Order Accounting by any of the following methods: Regulations.gov : http://www...

  2. 76 FR 28757 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-05-18

    ... DEPARTMENT OF DEFENSE Office of the Secretary [DOCKET ID DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Notice of Availability (NOA) of Revised...

  3. 76 FR 53119 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-08-25

    ... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Comment Addressed on Notice of...

  4. 76 FR 63896 - Federal Acquisition Regulation; Privacy Training, 2010-013

    Science.gov (United States)

    2011-10-14

    ... should a breach occur; and (7) Any agency-specific privacy training requirements. (d) The contractor is... Acquisition Regulation; Privacy Training, 2010-013 AGENCY: Department of Defense (DoD), General Services... contractors to complete training that addresses the protection of privacy, in accordance with the Privacy Act...

  5. 75 FR 26916 - Federal Acquisition Regulation: FAR Case 2009-004, Enhancing Contract Transparency

    Science.gov (United States)

    2010-05-13

    ... Regulation: FAR Case 2009-004, Enhancing Contract Transparency AGENCY: Department of Defense (DoD), General... commercial or financial information. This transparency effort is intended to promote efficiency in Government... the Administration's memorandum entitled Transparency and Open Government (January 21, 2009...

  6. 76 FR 68044 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-54; Small Entity Compliance Guide

    Science.gov (United States)

    2011-11-02

    ... Acquisition Circular 2005-54; Small Entity Compliance Guide AGENCY: Department of Defense (DoD), General... Federal Acquisition Circular (FAC) 2005-54, which amend the Federal Acquisition Regulation (FAR... (FAR Case 2009-006) This final rule amends the FAR to implement Executive Order (E.O.) 13494, Economy...

  7. 75 FR 19179 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-41; Small Entity Compliance Guide

    Science.gov (United States)

    2010-04-13

    ... Acquisition Circular 2005-41; Small Entity Compliance Guide AGENCIES: Department of Defense (DoD), General... Federal Acquisition Circular (FAC) 2005-41 which amends the Federal Acquisition Regulation (FAR... projects where the total cost to the Government is $25 million or more in order to promote economy and...

  8. 76 FR 58155 - Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services...

    Science.gov (United States)

    2011-09-20

    ... Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services Performance... performance evaluations for construction and architect-engineer services. DATES: Effective Date: September 20... past performance for construction and Architect- Engineer services. On April 19, 2011, DoD published a...

  9. 76 FR 52139 - Defense Federal Acquisition Regulation Supplement; Government; Property (DFARS Case 2009-D008)

    Science.gov (United States)

    2011-08-19

    ... responsibility for compliance with export control law and regulations a ``due diligence responsibility.'' DoD... clearance officer suspects data integrity issues; however, 245.602-1(2) has been clarified to specify... that the supplier name and part number be required for all items in Federal condition code A1 being...

  10. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-09

    ..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...

  11. 76 FR 31416 - Federal Acquisition Regulation; Oversight of Contractor Ethics Programs

    Science.gov (United States)

    2011-05-31

    ...-AL92 Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of... that contractors have implemented the mandatory contractor business ethics program requirements. DATES... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...

  12. 78 FR 6189 - Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise...

    Science.gov (United States)

    2013-01-29

    ... 9000-AM13 Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor... contractor in order to reimburse the tax imposed (26 U.S.C. 5000C Note). On February 22, 2012, DoD, GSA, and... with the statute, FAR 31.205-41 is amended to inform the Government and contractors that the costs of...

  13. 78 FR 13547 - Defense Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor Personnel

    Science.gov (United States)

    2013-02-28

    ... Contractor Personnel AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION... (FY) 2009 and expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Effective February 28, 2013. FOR FURTHER INFORMATION...

  14. 75 FR 66680 - Defense Federal Acquisition Regulation Supplement (DFARS); Continuation of Essential Contractor...

    Science.gov (United States)

    2010-10-29

    ...-AG52 Defense Federal Acquisition Regulation Supplement (DFARS); Continuation of Essential Contractor... that contractors providing essential contractor services, as determined by the requiring activity..., implementing the requirements of DoDI 3020.37, Continuation of Essential DoD Contractor Services During Crises...

  15. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ...; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD... collection requirement concerning cost accounting standards administration. A notice was published in the...- 0129, Cost Accounting Standards Administration by any of the following methods: Regulations.gov : http...

  16. 77 FR 30368 - Defense Federal Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices...

    Science.gov (United States)

    2012-05-22

    ... arrangement, the Government would take title to the devices during contract performance or at the conclusion... rule will promote utilization of domestic photovoltaic devices, even when the Government does not take... Devices (DFARS Case 2011-D046) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD...

  17. 77 FR 20598 - Defense Federal Acquisition Regulation Supplement: Solicitation Provisions and Contract Clauses...

    Science.gov (United States)

    2012-04-05

    ... commercial items, that includes the clause at 252.225-7001, Buy American Act and Balance of Payments Program... Acquisitions of Commercial Items AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... acquisition of commercial items and to specify flowdown of clauses to commercial subcontracts. DATES: Comments...

  18. 78 FR 70025 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2013-11-22

    ... and Procedures AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION... proposed information collection; (c) ways to enhance the quality, utility, and clarity of the information..., withhold, or withdraw purchasing system approval at the conclusion of a purchasing system review...

  19. Military Readiness: DODs Readiness Rebuilding Efforts May Be at Risk without a Comprehensive Plan

    Science.gov (United States)

    2016-09-01

    specific elements that are to be in strategic plans. 8Chairman of the Joint Chiefs of Staff Guide 3401D, CJCS Guide to the Chairman’s Readiness ...all its major functions and operations. DOD strategic guidance makes it clear that rebuilding readiness is a priority that supports the... readiness recovery efforts. Evaluations of the plan to monitor goals and objectives Assessments, through objective measurement and systematic

  20. DoD Depot-Level Reparable Supply Chain Management: Process Effectiveness and Opportunities for Improvement

    Science.gov (United States)

    2014-01-01

    Parts MIS Materiel Information Systems MRP material requirement planning NAVAIR Naval Air Systems Command viii DoD Depot-Level Reparable Supply...planning ( MRP ), which is run on the 15th of the month. The output of MRP is a time-phased buy and repair induction plan based on pro- jected demands...nine months in advance of the FY, planners begin work on the command schedule for the following year. From March through August, the monthly MRP

  1. DOD Future Energy Resources. Proceedings of Workshops Held at the National Defense University

    Science.gov (United States)

    2003-05-01

    fermentation of the cellulosic and hemicellulosic sugars, lignin remains as a residue. ( Lignin does not contain any sulfur and is consequently called “clean...Patzek, “Ethanol From Corn : Clean Renewable Fuel for the Future, or Drain on Our Resources and Pockets?” Working paper , University of California...to DOD and national policy, nor did he address any of the concerns presented in the opening premise of this paper . Instead, he stated his views as

  2. DOD Business Systems Modernization: Further Actions Needed to Address Challenges and Improve Accountability

    Science.gov (United States)

    2013-05-01

    to Lack Adequate Validation Page 35 GAO-13-557 DOD Business Systems Modernization provided a compliance dashboard to document BEA...campaigns, execute marketing campaigns, and measure and evaluate the performance of marketing campaigns. Order-to- Cash Accept and process customer... dashboards reflected related GAO reports. In addition, the department’s fiscal year 2014 investment management guidance issued by the Office of the

  3. Bulk Fuel: Actions Needed to Improve DODs Fuel Consumption Budget Data

    Science.gov (United States)

    2016-09-01

    be reimbursed with more cash than it anticipated. DOD and military service financial management officials prepare budget justification materials...Overseas Contingency Operations OMB Office of Management and Budget OUSD Office of the Under Secretary of Defense This is a work of the U.S...military service budget and financial management offices, and DLA to determine how O&M budget justification materials generally, and fuel

  4. Defense Weather Satellites: DOD Faces Acquisition Challenges for Addressing Capability Needs

    Science.gov (United States)

    2016-07-07

    and compare the operational effectiveness and life cycle costs of potential solutions. This testimony is based on a report GAO issued in March...Technology, House of Representatives For Release on Delivery Expected at 10 a.m. ET Thursday, July 7, 2016 GAO-16-769T United States...Environment, Committee on Science, Space, and Technology, House of Representatives July 2016 DEFENSE WEATHER SATELLITES DOD Faces Acquisition

  5. Assessment of DoD Voting Assistance Programs for Calendar Year 2015

    Science.gov (United States)

    2016-03-31

    absentee ballot application process and the privacy of the identity and personal data of UOCAVA voters using the procedures. DoD Guidance DoD...Collection of these new performance metrics commenced on January 1, 2015; therefore, CY 2015 is the first full reporting cycle in which the new Measures of... privacy of the contents of absentee ballots cast by absentee uniformed services voters and overseas voters while such ballots are in the possession or

  6. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 3

    Energy Technology Data Exchange (ETDEWEB)

    Soderquist, J.R.; Neri, L.M.; Bohon, H.L.

    1992-09-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing. Separate abstracts have been prepared for articles from this report.

  7. Retention, Incentives, and DoD Experience Under the 40-Year Military Pay Table

    Science.gov (United States)

    2016-01-01

    Beth J. Asch, James Hosek, Jennifer Kavanagh, Michael G. Mattock Retention, Incentives, and DoD Experience Under the 40-Year Military Pay Table C O...Authorization Act (NDAA) directed the Secretary of Defense to review the military’s pay tables, focusing on whether the 40-year pay table is still justified as...a retention tool. Congress extended the pay tables to 40 years as part of the fiscal year 2007 NDAA to pro- vide an incentive for the most

  8. An Analysis of the Impact of Non DoD Conference Policy Change

    Science.gov (United States)

    2016-09-01

    release. Distribution is unlimited. THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public...conference requests. 14. SUBJECT TERMS travel, conference travel, non-DOD conference, cost benefit analysis, DTS, JTR, activity- based accounting ...John Dillard, for their assistance and guidance throughout the process of writing this report. In addition, they are grateful to Mary Aguilar, Marc

  9. Crossing the technology adoption chasm in the presence of network externalities implications for DoD

    OpenAIRE

    Schang, Suzanne L.

    2007-01-01

    This thesis explores factors inhibiting technologies from crossing the technology diffusion "chasm" in between early and wide-scale adoption. It focuses on cost and benefit uncertainty as well as network effects applied to end-users and their organizations. Specifically, it explores Department of Defense (DoD) acquisition programs bringing promising technologies to the field defines successful technology adoption as realizing its full potential return on investment by achieving the widest ...

  10. A Fixed-Wing Aircraft Simulation Tool for Improving the efficiency of DoD Acquisition

    Science.gov (United States)

    2015-10-05

    simulation tool , CREATETM-AV Helios [12-14], a high fidelity rotary wing vehicle simulation tool , and CREATETM-AV DaVinci [15-16], a conceptual through...05/2015 Oct 2008-Sep 2015 A Fixed-Wing Aircraft Simulation Tool for Improving the Efficiency of DoD Acquisition Scott A. Morton and David R...multi-disciplinary fixed-wing virtual aircraft simulation tool incorporating aerodynamics, structural dynamics, kinematics, and kinetics. Kestrel allows

  11. Best Practices for Optimizing DoD Contractor Safety and Occupational Health Program Performance

    Science.gov (United States)

    2012-12-01

    acts and omissions. DoD’s duty arises under OSHA’s Multi-Employer Citation Policy, and in tort and admiralty law, as discussed in Section 2.6...unnecessarily subject the government to legal liability for on-the-job injuries under the Federal Tort Claims Act (FTCA). (b) The government may...housing or any other contractual context. Furthermore, DoD can place itself in a similar position via negligence , or contractual actions as well as

  12. Defense Infrastructure: DOD Efforts to Prevent and Mitigate Encroachment at Its Installations

    Science.gov (United States)

    2016-11-01

    installation size and projected population growth . What GAO Recommends GAO is not making recommendations in this report. DOD provided technical...Projected Population Growth at 33 Selected Installations (2015 to 2020) 32 Table 4: Summary of Benefits Reported by Readiness and Environmental...installation of interest because of the existence of or potential for future incompatible land use, and (4) projected population growth in adjacent

  13. Enhancing Cross-Cultural Collaboration between DoD and VA

    Science.gov (United States)

    2012-04-27

    Philadelphia. In 1853 and 1855, the Soldiers Home and St. Elizabeth’s Hospital followed in Washington, DC. In 1866, Congress established the National Homes...veterans. The quality of medical care at these homes improved until it was comparable to hospital care of that day. In 1862, the National Cemetery...Evaluation System WG Pain Management WG DoD Recovery Coordination Program ( RCP )* Federal Recovery Coordination Program (FRCP)* * Programs with JEC

  14. Federal Research Opportunities: DOE, DOD, and HHS Need Better Guidance for Participant Activities

    Science.gov (United States)

    2016-01-01

    contract with DOE and the Economy Act of 1932, as amended. In addition, we examined documents developed by ORAU and used by DOE, DOD, and HHS to set forth...energy and climate change policy and analyses in the international economy , and building efficiencies. Environmental Protection Agency Climate...biomarkers for environmental contaminants. Federal Bureau of Investigation Juvenile prostitution and child abduction, causes of postmortem hair root

  15. Perspectives on Research in Artificial Intelligence and Artificial General Intelligence Relevant to DoD

    Science.gov (United States)

    2017-01-01

    use of AI technologies in speech recognition, Internet search, and Facebook image tagging. Movie viewers take for granted the spectacular, or...applications relevant to DoD missions. Humanoid robots of malign intent are a Hollywood staple—ironically, rendered on film by benign AI technologies...different meanings, one relating to “ freedom of will or action” (like humans, or as in AGI), and the other the much more prosaic ability to act in

  16. DOD Space Systems: Additional Knowledge Would Better Support Decisions about Disaggregating Large Satellites

    Science.gov (United States)

    2014-10-01

    considering new approaches. According to Air Force Space Command, U.S. space systems face intentional and unintentional threats , which have increased...life cycle costs • Demand for more satellites may stimulate new entrants and competition to lower acquisition costs. • Smaller, less complex...Fiscal constraints and growing threats to space systems have led DOD to consider alternatives for acquiring space-based capabilities, including

  17. The Lean Acquisition Strategy Behind the DOD’s 2015 Electronic Health Record System

    Science.gov (United States)

    2016-09-01

    the acquisition of CHCS, numerous errors caused delays in system development contracting. First, the DOD miscommunicated with some vendors and...Unsolidified program milestones Manager Lack of commitment Program focus on home-grown solutions 3. Question 2: What Were the Key Obstacles and Risks...differences in a way … solutions are presented” (personal communication, June 10, 2016). Program manager 1 echoes the findings from the survey that the

  18. Bulk Fuel Pricing: DOD Needs to Take Additional Actions to Establish a More Reliable Methodology

    Science.gov (United States)

    2015-11-19

    Page 1 GAO-16-78R Bulk Fuel Pricing 441 G St. N.W. Washington, DC 20548 November 19, 2015 The Honorable Ashton Carter The Secretary of...Defense Bulk Fuel Pricing : DOD Needs to Take Additional Actions to Establish a More Reliable Methodology Dear Secretary Carter: Each fiscal...year, the Office of the Under Secretary of Defense (Comptroller), in coordination with the Defense Logistics Agency, sets a standard price per barrel

  19. Transforming the Way DOD Looks at Energy. An Approach to Establishing an Energy Strategy

    Science.gov (United States)

    2007-04-01

    cle systems, which increase fuel efficiency by using batteries to store energy that is recaptured from the braking process via regenerative braking ...Identify possible solutions from options in the organize, engineer, or in- vent categories . This will help determine the relative risk, the...understanding of the DoD energy consumption profile (how and where is energy being consumed).13 Energy consumption falls into two categories : facility

  20. Embedded with Facebook: DoD Faces Risks from Social Media

    Science.gov (United States)

    2011-06-01

    Facebook and other social network websites, and now allows them to be used from official computer systems and...appropriate conduct. Embedded with Social Media Today Facebook is the world’s dominant social network site. Facebook boasts over 600 million active users...billion minutes on the site each month [4]. Facebook is also the most popular social network site for DoD personnel. Using our techniques for

  1. DoD Use of Commercial Acquisition Practices When They Apply and When They Do Not

    Science.gov (United States)

    2015-10-01

    Defense AT&L: September–October 2015 2 From the Under Secretary of Defense for Acquisition, Technology , and Logistics DoD Use of...that an item is offered as a commercial product; next, the need to access cutting-edge commercial technologies ; and, finally, those cases where we...For purely commercial items widely and competitively sold on the open market, this is easy. For thousands of items, from office furniture to cleaning

  2. Beyond Demonstration: The Role of Fuel Cells in DoD’s Energy Strategy

    Science.gov (United States)

    2011-10-19

    interest to DoD, in part by obtaining rec- ommendations from organizations with an interest in fuel cells. Analysis and feedback led us to define 11...FuelCell Energy manufactures MCFC systems. They are nor- mally operated using natural gas, but they can also run on re- newable fuels such as biogas ...of the base load power at the Gills Onions processing facility in Oxnard, CA. Installed in 2009, the fuel cell system uses biogas produced from

  3. DoD Information Technology Acquisition: Delivering Information Technology Capabilities Expeditiously

    Science.gov (United States)

    2013-09-01

    but they possess limited IT acquisition experience (Fryer- Biggs , 2012). According to Frank Kendall (2012), USD(AT&L), acquisition personnel need...we have a very long recovery time to correct it. (Fryer- Biggs , 2012) The DoD has the means to develop its own trained professionals but even that... John P. Kotter (1996) postulated what he considered to be the primary reasons why change efforts fail. Kotter offered eight reasons why this failure

  4. Defense Commissaries: DOD Needs to Improve Business Processes to Ensure Patron Benefits and Achieve Operational Efficiencies

    Science.gov (United States)

    2017-03-01

    preferences by age, income , job position, and a variety of other demographics, to better target products that are sold at commissaries. Senior DeCA...found that DOD’s report did not define specific metrics for benchmarks for customer satisfaction , quality of products, and patron savings. We...alternative reductions to appropriations, and identify specific metrics for customer satisfaction , quality of products, and patron savings. DOD concurred

  5. Military Training: DOD Met Annual Reporting Requirements in Its 2016 Sustainable Ranges Report

    Science.gov (United States)

    2016-06-01

    copyrighted images or other material , permission from the copyright holder may be necessary if you wish to reproduce this material separately...which the report met mandated statutory requirements and whether DOD faced challenges in preparing its report. We conducted this performance audit ...from March 2016 to June 2016 in accordance with generally accepted government auditing standards. Those standards require that we plan and perform

  6. DOD Financial Management: Continued Actions Needed to Address Congressional Committee Panel Recommendations

    Science.gov (United States)

    2015-09-01

    which was intended to fundamentally transform DOD’s financial management operations and achieve clean financial 12GAO-15-290. 13GAO-15-290. 14Pub...Actions to Implement the Panel on Defense Financial Management and Auditability Reform Recommendations valuations for these assets. For example, DOD’s...governance, the department is managing its business systems, including ERP systems, as portfolios of investments . The goal is to aggregate data from

  7. REGULATION OF INSTANTANEOUS POWER OUTPUT VALUE IN MAGNETRON WITH CONTINUOUS GENERATION MODE (M-105-, M-112-TYPES BEING PART OF PLASMA TECHNOLOGICAL UNIT

    Directory of Open Access Journals (Sweden)

    S. V. Bordusov

    2010-01-01

    Full Text Available The paper presents results of investigations pertaining to the possibility of regulating instantaneous power output  in a magnetron of M-105 (M-112-type by changing the capacity value of a capacitor in structure diagram for doubling voltage of high-voltage power supply on the basis of a step-up transformer operating in the saturation regime.

  8. Current regulator for the stabilization of an electrostatic Van de Graaff generator; Regulateur de courant pour stabilisation d'un generateur electrostatique Van de Graaff

    Energy Technology Data Exchange (ETDEWEB)

    Gabet, A; Taieb, J [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

    1953-07-01

    In a previous report (CEA report number 46) we described a current regulator destined to enslave the current of charge of the strap of a model of Van de Graaff. We will now describe the regulator destined to the 5 MeV Van de Graaff built in the Nuclear center of Saclay. (author) [French] Dans un precedent rapport (rapport C.E.A. numero 46) nous avons decrit un regulateur de courant destine a asservir le courant de charge de la courroie d'une maquette de Van de Graaff. Nous decrirons maintenant le regulateur destine au Van de Graaff de 5 MeV construit au Centre d'Etudes Nucleaires de Saclay. (auteur)

  9. Chemical and Biological Defense: DOD Needs Consistent Policies and Clear Processes to Address the Survivability of Weapon Systems Against Chemical and Biological Threats

    National Research Council Canada - National Science Library

    2006-01-01

    DOD, joint, and military service weapon system acquisition policies inconsistently address and do not establish a clear process for considering and testing system chemical and biological survivability...

  10. Do Self-Regulated Processes such as Study Strategies and Satisfaction Predict Grade Point Averages for First and Second Generation College Students?

    Science.gov (United States)

    DiBenedetto, Maria K.

    2010-01-01

    The current investigation sought to determine whether self-regulatory variables: "study strategies" and "self-satisfaction" correlate with first and second generation college students' grade point averages, and to determine if these two variables would improve the prediction of their averages if used along with high school grades and SAT scores.…

  11. NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 11: The Voice of the User: How US Aerospace Engineers and Scientists View DoD Technical Reports

    Science.gov (United States)

    Pinelli, Thomas E.; Kennedy, John M.

    1991-01-01

    The project examines how the results of NASA/DOD research diffuse into the aerospace R&D process, and empirically analyzes the implications of the aerospace knowledge diffusion process. Specific issues considered are the roles played by government technical reports, the recognition of the value of scientific and technical information (STI), and the optimization of the STI aerospace transfer system. Information-seeking habits are assessed for the U.S. aerospace community, the general community, the academic sector, and the international community. U.S. aerospace engineers and scientists use 65 percent of working time to communicate STI, and prefer 'internal' STI over 'external' STI. The isolation from 'external' information is found to be detrimental to U.S. aerospace R&D in general.

  12. Natural gas power generation: interruptible gas distribution network regulation; Geracao termoeletrica a gas natural: regulacao do segmento interruptivel de distribuicao de gas canalizado

    Energy Technology Data Exchange (ETDEWEB)

    Paula, Claudio Paiva de; Kann, Zevi [Agencia Reguladora de Saneamento e Energia do Estado de Sao Paulo (ARSESP), SP (Brazil)

    2008-07-01

    The paper relates studies regarding the natural gas distribution network interruptible branch. This new service can be appropriate for thermal power generation on flexible dispatch mode, as 'take or pay' contracts surplus jobs. The paper indicates no regulatory restraints in an interruptible network implantation. The final conclusion is that interruptible contracts can be an improvement on the distribution business and certainly can accommodate a suitable demand and supply volumes in the long-term gas market balance. (author)

  13. Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa.

    Science.gov (United States)

    Reales-Calderón, Jose Antonio; Corona, Fernando; Monteoliva, Lucía; Gil, Concha; Martínez, Jose Luis

    2015-09-08

    Recent research indicates that the post-transcriptional regulator Crc modulates susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Several P. aeruginosa virulence factors are secreted or engulfed in vesicles. To decipher the Crc modulation of P. aeruginosa virulence, we constructed a crc deficient mutant and measure the proteome associated extracellular vesicles and the vesicle-free secretome using iTRAQ. Fifty vesicle-associated proteins were more abundant and 14 less abundant in the crc-defective strain, whereas 37 were more abundant and 17 less abundant in the vesicle-free secretome. Among them, virulence determinants, such as ToxA, protease IV, azurin, chitin-binding protein, PlcB and Hcp1, were less abundant in the crc-defective mutant. Transcriptomic analysis revealed that some of the observed changes were post-transcriptional and, thus, could be attributed to a direct Crc regulatory role; whereas, for other differentially secreted proteins, the regulatory role was likely indirect. We also observed that the crc mutant presented an impaired vesicle-associated secretion of quorum sensing signal molecules and less cytotoxicity than its wild-type strain. Our results offer new insights into the mechanisms by which Crc regulates P. aeruginosa virulence, through the modulation of vesicle formation and secretion of both virulence determinants and quorum sensing signals. This article is part of a Special Issue entitled: HUPO 2014. Published by Elsevier B.V.

  14. Digital Elevation Models of Differences (DODs): implementation for assessment of soil erosion on recreational trails.

    Science.gov (United States)

    Tomczyk, A.; Ewertowski, M.

    2012-04-01

    Introduction: Tourism's negative impact on protected mountain areas is one of the main concerns for land managers. The impact on the natural environment is the most visible at locations of highly concentrated activities such as tourist trails, campsites, etc. The main indicators of the tourist trail degradation are vegetation loss (trampling of vegetation cover), change of vegetation type and composition, trail widening, muddiness and soil erosion. The last one is especially significant, since it can cause serious transformation to the land surface. Such undesirable changes cannot be repaired without high-cost management activities and in some cases they can made the trails difficult and unsafe to use. The scientific understanding of soil erosion in relation to human impact can be useful for a more effective management of protected natural areas (PNAs). The main objectives of this study are: (1) to analyse the spatial aspect of surface changes in microscale; (2) to quantify precisely the short-term rate of soil loss and deposition. Study area and methods: To gather precise and objective elevation data, an electronic total station with microprism were used. Measurements were taken in 12 test fields, located in two protected natural areas in south Poland: the Gorce National Park and Popradzki Landscape Park. The measuring places were located on the trails characterized by different slope, types of vegetation, and types of use. Each of the test fields was established by four special marks, firmly dug into the ground. Five sessions of measurement was carried out for each test field: August/September 2008, June 2009, August/September 2009, June 2010, August/September 2010. Generated DEMs (based on field surveys' results) were subtracted from each other, and thus we obtained a spatial picture of the loss or deposition of soil in each cell of the model, from one survey session to another. The subtraction of DEMs from subsequent time periods (DEMs of Difference - DoDs gave

  15. Evaluation of IDA-80 data by the DoD method

    International Nuclear Information System (INIS)

    Beyrich, W.; Golly, W.

    1989-12-01

    The measurement data of 28 interlaboratory analysis performed under the IDA-80 programme are evaluated by the DoD (Distribution of Differences) method with respect to the RSDs of the interlaboratory spreads and the within-laboratory uncertainty components. The resulting estimates are compared to those obtained by variance analysis after application of outlier criteria in the official IDA-80 evaluation. Deviations found in case of the within-laboratory uncertainty components ('run' component of the IDA-80 evaluation) are discussed. (orig./HP) [de

  16. Regulation of Electrochemically Generated H2O2 in Situ from a Novel CB-PTFE Cathode for Transformation of Chlorine Benzene in Groundwater

    Science.gov (United States)

    Jiang, J.; Zhang, X.; Li, G.

    2014-12-01

    Fenton's reagents (H2O2 and Fe2+ catalyst commonly) have been widely used in soil and groundwater remediation. But the excessive H2O2 decomposition and the pH modification (acidification) problem have been limitations for Fenton based remediation strategies. The Electro-Fenton (E- Fenton) processes has been recently developed to solve the problems, in which Fe2+ or H2O2are generated in situ as continuing source of Fenton's reagents. In this study, a novel CB-PTFE cathode and a Fe cathode were employed to generate H2O2 and Fe2+ in situ simultaneously. The generated reactive oxidizing species, i.e., O2,H2O2 and hydroxyl radical (HO•), oxidized bio-refractory organics to nontoxic matters in groundwater. Automatic pH adjustments are achieved by appropriately arraying the electrodes. Laboratory batch tests and column tests for the E-Fenton oxidation and hybrid electrolysis system were conducted to evaluate the transformation efficiency of chlorine benzene. Results from batch experiments suggested the CB-PTFE cathode was effective for reducing O2 to H2O2. The H2O2 concentration reached 468 mg/L under the condition of pH 3.0 and 30mA/cm2 in 60 minutes, which was 5 and 10 times of that with a graphite and C-felt cathode. The removal efficiency of chlorine benzene reached 80% in 20 minutes. Both chlorine benzene degradation and H2O2 production increased with decreasing solution pH and increasing current density. The results from the columns tests proved that the in situ E-Fenton system is a feasible method for groundwater remediation.

  17. NPOESS Interface Data Processing Segment Product Generation

    Science.gov (United States)

    Grant, K. D.

    2009-12-01

    The National Oceanic and Atmospheric Administration (NOAA), Department of Defense (DoD), and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation weather and environmental satellite system; the National Polar-orbiting Operational Environmental Satellite System (NPOESS). NPOESS replaces the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA and the Defense Meteorological Satellite Program (DMSP) managed by the DoD. The NPOESS satellites carry a suite of sensors that collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The NPOESS design allows centralized mission management and delivers high quality environmental products to military, civil and scientific users. The ground data processing segment for NPOESS is the Interface Data Processing Segment (IDPS), developed by Raytheon Intelligence and Information Systems. The IDPS processes NPOESS satellite data to provide environmental data products to NOAA and DoD processing centers operated by the United States government. The IDPS will process environmental data products beginning with the NPOESS Preparatory Project (NPP) and continuing through the lifetime of the NPOESS system. Within the overall NPOESS processing environment, the IDPS must process a data volume nearly 1000 times the size of current systems -- in one-quarter of the time. Further, it must support the calibration, validation, and data quality improvement initiatives of the NPOESS program to ensure the production of atmospheric and environmental products that meet strict requirements for accuracy and precision. This paper will describe the architecture approach that is necessary to meet these challenging, and seemingly exclusive, NPOESS IDPS design requirements, with a focus on the processing relationships required to generate the NPP products.

  18. 75 FR 18029 - Defense Federal Acquisition Regulation Supplement; Export-Controlled Items (DFARS Case 2004-D010)

    Science.gov (United States)

    2010-04-08

    ... regulations and prescribes a contract clause to address those responsibilities. DATES: Effective Date: April 8... activities and communication between the parties to a potential contract, and to have the resulting contract... Government needs to convey to the universities the information that certain work is export-controlled. DoD...

  19. U.S. Transportation Command's Reporting of Property, Plant, and Equipment Assets on the FY 2000 DoD Agency-Wide Financial Statements

    National Research Council Canada - National Science Library

    Granetto, Paul

    2001-01-01

    .... The accuracy of the $78 billion of property, plant, and equipment reported on the FY 2000 DoD Agency-Wide Financial Statements is essential to DoD receiving favorable audit opinions on its financial statements. The U.S...

  20. 32 CFR Appendix C to Part 247 - Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and Distribution of...

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Mailing of DoD Newspapers, Magazines, CE Guides...) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. C Appendix C to Part 247—Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and...