WorldWideScience

Sample records for regulations system department

  1. Mining Department computer systems

    Energy Technology Data Exchange (ETDEWEB)

    1979-09-01

    Describes the main computer systems currently available, or being developed by the Mining Department of the UK National Coal Board. They are primarily for the use of mining and specialist engineers, but some of them have wider applications, particularly in the research and development and management statistics fields.

  2. 48 CFR 1252.217-80 - Department of Labor Safety and Health Regulations for Ship Repairing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Department of Labor Safety and Health Regulations for Ship Repairing. 1252.217-80 Section 1252.217-80 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-80...

  3. Systems Analysis Department annual progress report 1998

    DEFF Research Database (Denmark)

    1999-01-01

    The report describes the work of the Systems Analysis Department at Risø National Laboratory during 1998. The department undertakes research within Energy Systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, IndustrialSafety and Reliability, Man/Machine Interac....../Machine Interaction, and Technology Scenarios. The report includes lists of publications, lectures, committees and staff members....

  4. Systems Analysis Department annual progress report 1999

    DEFF Research Database (Denmark)

    2000-01-01

    This report describes the work of the Systems Analysis Department at Risø National Laboratory during 1999. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety,Realiability and Human Factors, and Technology...

  5. Systems Analysis Department. Annual Report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, H.; Olsson, C. (eds.)

    2004-04-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2003. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and list of staff members. (au)

  6. Systems Analysis Department. Annual Report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Duijm, N J; Jensen, E; Larsen, H; Skipper, S [eds.

    2002-04-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2001. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  7. Systems Analysis Department annual report 2003

    DEFF Research Database (Denmark)

    2004-01-01

    This report describes the work of the Systems Analysis Department at Risø National Laboratory during 2003. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning – UNEP Centre, Safety,Reliability and Human Factors, and Technology...... Scenarios. The report includes summary statistics and list of staff members....

  8. Systems Analysis Department. Annual Progress Report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Loevborg, Leif [eds.

    2000-03-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1999. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning-UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  9. Systems Analysis department. Annual progress report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Petersen, Kurt E

    1998-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1997. The department is undertaking research within Energy systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, Industrial Safety and Reliability and Man/Machine Interaction. The report includes lists of publications lectures, committees and staff members. (au) 110 refs.

  10. Systems Analysis Department. Annual progress report 1996

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, H; Olsson, C; Petersen, K E [eds.

    1997-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1996. The department is undertaking research within Simulation and Optimisation of Energy Systems, Energy and Environment in Developing Countries - UNEP Centre, Integrated Environmental and Risk Management and Man/Machine Interaction. The report includes lists of publications, lectures, committees and staff members. (au) 131 refs.

  11. System Analysis Department. Annual Report 2002

    Energy Technology Data Exchange (ETDEWEB)

    Duijm, N J; Jensen, E; Larsen, H; Skipper, S [eds.

    2002-04-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2001. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  12. Systems Analysis Department. Annual Report 2000

    Energy Technology Data Exchange (ETDEWEB)

    Duijm, N J; Jensen, E; Larsen, H; Olsson, C

    2001-05-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 2000. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  13. Systems Analysis Department annual progress report 1998

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Loevborg, Leif [eds.

    1999-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1998. The department undertakes research within Energy Systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, Industrial Safety and Reliability, Man/Machine Interaction and Technology Scenarios. The report includes lists of publications, lectures, committees and staff members. (au) 111 refs.

  14. Systems analysis department annual progress report 1986

    International Nuclear Information System (INIS)

    Grohnheit, P.E.; Larsen, H.; Vestergaard, N.K.

    1987-02-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1986. The activities may be classified as energy systems analysis and risk and reliability analysis. The report includes a list of staff members. (author)

  15. Moving from self-regulation to external regulation of Department of Energy facilities

    International Nuclear Information System (INIS)

    Wishau, R.J.; Dawson, J.; Lee, D.W.

    1999-01-01

    This paper discusses the initiative to transfer the regulation of Department of Energy (DOE) nuclear facilities to the US Nuclear Regulatory Commission (NRC). The paper gives an overview of some of the major technical, policy and legal issues that accompany this initiative. The paper focuses on specific issues and how they may be affected by external regulation of occupational radiation protection at DOE facilities. Differences between the NRC and the DOE approach to regulating nuclear safety are compared and contrasted. Some projected impacts from this transition are examined. Finally, recommendations are provided that may enhance the transition, increasing the likelihood of successful external NRC regulation

  16. MSFC Propulsion Systems Department Knowledge Management Project

    Science.gov (United States)

    Caraccioli, Paul A.

    2007-01-01

    This slide presentation reviews the Knowledge Management (KM) project of the Propulsion Systems Department at Marshall Space Flight Center. KM is needed to support knowledge capture, preservation and to support an information sharing culture. The presentation includes the strategic plan for the KM initiative, the system requirements, the technology description, the User Interface and custom features, and a search demonstration.

  17. Combat Systems Department Employee Recognition System

    National Research Council Canada - National Science Library

    1996-01-01

    This handbook contains two types of information: guidelines and instructions. The guidelines provide a foundation of purpose, assumptions, principles, expectations and attributes the Employee Recognition System is designed to reflect...

  18. 19 CFR 12.24 - Regulations of the Department of Agriculture.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Regulations of the Department of Agriculture. 12... Feeding Materials § 12.24 Regulations of the Department of Agriculture. (a) The importation into the... and quarantine regulations of the Department of Agriculture, Customs officers and employees are...

  19. INFORMATION SYSTEM FOR DEPARTMENT OF RECONSTRUCTIVE NEUROSURGERY

    Directory of Open Access Journals (Sweden)

    V. I. Tsymbaliuk

    2015-05-01

    Full Text Available This article is about creating information system for the rehabilitation Department of Neurosurgery. To develop the information system needs to explore the work of department, examine the medical documentation and statistical reporting forms which doctors using in their work. Determine the sequence of making records into documentation. And finally make list of requirements for application with help of medical staff. The software was developed by using C# language and the database server MySQL. It has five major systems and several ancillary subsystems. The major systems are: saving personal and clinical patient information, editing inputted data, showing data, ensuring the integrity and accuracy of database, the implementation of access to the same database from different computers. Auxiliary subsystems include: creating medical documentation, blocking form’s elements, searching for patient through database, making statistic over some period of time, creating folders for every patient and others. There was designed user interface that allows doctors to reduce time for learning functionality of application. Information system has positive effect. It saves time for medical staff and reduces the possibility of inputting wrong information. Application does not require high hardware characteristics of computer.

  20. The Department of Safeguards Quality Management System

    International Nuclear Information System (INIS)

    Konecni, S.

    2015-01-01

    The International Atomic Energy Agency (IAEA) Department of Safeguards quality management system (QMS) provides the framework for all activities that support the Agency's commitment to providing soundly-based safeguards conclusions regarding the peaceful use of nuclear material. The focus of the QMS is to enhance the effectiveness and efficiency of safeguards implementation through defined, documented processes, routine oversight and continual improvement initiatives. In accordance with QMS principles, the high-level business processes representing the Department's activities are defined in procedures, guidelines and policies that are maintained in the Safeguards Document Manager. These processes form the basis for Department operations for drawing safeguards conclusions regarding State's compliance with their safeguards obligations. Oversight is provided through internal quality audits. These audits are targeted at processes selected by Senior Management with a focus on procedure compliance as well as customer expectations. Best practices and areas for improvement are assessed through continual improvement. Noncompliance and conditions that are adverse to quality are identified and analyzed in the Condition Report System. Root cause analysis and the implementation actions to eliminate the cause reduce the chance of condition recurrence. Through continual process improvement, processes are measured and analyzed to reduce process and administration waste. The improved processes improve efficiency while providing the desired results. Within the scope of the QMS, these tools support the performance of Departmental processes so that Safeguards products achieve the intended purpose. This paper describes how the various elements of the Department's QMS support safeguards implementation. (author)

  1. Intelligent tutoring system of the university department

    Directory of Open Access Journals (Sweden)

    A. S. Aleshchenko

    2016-01-01

    Full Text Available The aim of the research is intelligent tutoring system for planning and development of individual learning programs for students. One of the important components of modern training programs is the individual practice programs that are formed from the first course and built up in the process of learning in the subsequent courses. Each individual practice program is formed on the basis of the Working program of practice for a specific group. At later practice stages planning and adjustment of the individual program are worked out for a particular student.The agent-oriented approach for the planning of individual learning programs is used for the formation of individual practice program. Agents of the intelligent learning systems are created according to the requirements of service-oriented architecture. To apply knowledge there used an integrated approach to represent knowledge.As a result of research, the authors propose the architecture of intelligent educational systems of the University Department, using the repository of learning objects, telecommunication systems and such agents as: the learner, the assessment of the student’s knowledge, the formation of individual programs for learning, the personal learning environment, the methodical support, the businesses. The authors demonstrate the possibility for the formation of individual practice programs using an agent of the methodical support.Application of the approaches and technologies which were considered in the article will allow to solve problems of the formation of individual practice programs. The use of such applications will extend the possibilities of intelligent tutoring systems of the University departments.

  2. 19 CFR 12.10 - Regulations and orders of the Department of Agriculture.

    Science.gov (United States)

    2010-04-01

    ... Agriculture. 12.10 Section 12.10 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Regulations and orders of the Department of Agriculture. The importation into the United States of plants and plant products is subject to regulations and orders of the Department of Agriculture restricting or...

  3. 48 CFR 3410.703 - Responsibilities of the Department of Education with respect to use of the metric system.

    Science.gov (United States)

    2010-10-01

    ... Department of Education with respect to use of the metric system. 3410.703 Section 3410.703 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION COMPETITION AND ACQUISITION... Responsibilities of the Department of Education with respect to use of the metric system. (a) Consistent with the...

  4. 76 FR 20249 - Department of State Acquisition Regulation

    Science.gov (United States)

    2011-04-12

    ... number 1405-0050. List of Subjects in 48 CFR Parts 604, 637 and 652 Government procurement, Electronic... Latvanas, Procurement Analyst, Department of State, Office of the Procurement Executive, 2201 C Street, NW..., local, and tribal governments, in the aggregate, or by the private sector, of $100 million or more in...

  5. How characteristic routines of clinical departments influence students' self-regulated learning : A grounded theory study

    NARCIS (Netherlands)

    Berkhout, J J; Slootweg, I. A.; Helmich, Esther; Teunissen, P W; van der Vleuten, C. P. M.; Jaarsma, A. D. C.

    2017-01-01

    Background: In clerkships, students are expected to self-regulate their learning. How clinical departments and their routine approach on clerkships influences students' self-regulated learning (SRL) is unknown.Aim: This study explores how characteristic routines of clinical departments influence

  6. 48 CFR 3410.701 - Policy of the Department of Education with respect to use of the metric system.

    Science.gov (United States)

    2010-10-01

    ... of Education with respect to use of the metric system. 3410.701 Section 3410.701 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION COMPETITION AND ACQUISITION PLANNING... of Education with respect to use of the metric system. It is the policy of the Department of...

  7. REGULATION OF NATIONAL QUALIFICATIONS SYSTEMS

    Directory of Open Access Journals (Sweden)

    Anna A. Muravyeva

    2014-01-01

    Full Text Available The paper looks into the diverse aspects of qualifications system regulation, designed for balancing the supply and demand in the labor and educational service markets. Both the objects and mechanisms of such regulation are described. Special attention is given to institutions, involved in regulation of qualifications, and their jurisdiction. Another emphasis is on the industry-related regulation of qualifications which proved to be effective both on the national and European level. Such structures were first established on the national levels to regulate the qualifications and ensure their comparability and compatibility, given the economic globalization and growing labor and academic mobility. The author points out the role of the ministries of education and labor in maintaining a steady qualifications system, and outlines the positive experience of Great Britain using the industry councils for continuing development of qualifications system.

  8. Department

    African Journals Online (AJOL)

    USER

    2016-09-20

    Sep 20, 2016 ... Department of Biological and Environmental Sciences, Kibabii University. Abstract. This study ... Key Words: Climate Change, Regional Circulation Model, PRECIS, Bungoma County ... by different computer models is much.

  9. 42 CFR 57.216 - What additional Department regulations apply to schools?

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What additional Department regulations apply to schools? 57.216 Section 57.216 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN... schools? (a) Participating schools are advised that in addition to complying with the terms and conditions...

  10. 42 CFR 57.316 - What additional Department regulations apply to schools?

    Science.gov (United States)

    2010-10-01

    ... schools? 57.316 Section 57.316 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN... STUDENT LOANS Nursing Student Loans § 57.316 What additional Department regulations apply to schools? Participating schools are advised that in addition to complying with the terms and conditions of these...

  11. Department of Defense Intelligence Information System

    National Research Council Canada - National Science Library

    Gimble, Thomas

    1994-01-01

    The objectives of the audit were to determine whether the systems that comprise the DoDIIS are interoperable and whether oversight of acquisition management is adequate to assure that the development...

  12. Public Works Department Maintenance Management Information System

    Science.gov (United States)

    1976-06-01

    Associates, Inc., 1974. 2. Ansoff , Igor H. , Corporate Strategy , McGraw-Hill Book Co., 1965. 3. Anthony, Robert N. , Planning and Control Systems, A...hierarchy of information systems. Ansoff describes management decision-making in three categories as strategic, administrative and operating decisions [Re...involve the firm’s goals, objectives, diversification, product-mix, markets, and growth. Ansoff also notes these other differences: 76 (1) operating

  13. An Evaluation of the Cybersecurity Policies for the United States Health & Human Services Department: Criteria, Regulations, and Improvements

    Directory of Open Access Journals (Sweden)

    Derek Mohammed

    2014-04-01

    Full Text Available This paper examines the criteria necessary for the evaluation of the cybersecurity policies for the United States Health and Human Services Department of the Federal Government. The overall purpose of cybersecurity policies and procedures is supported through compliance with Federal mandated regulation and standards, which serve to protect the organizational services and goals of the United States Health and Human Services Department, and to promote the best possible security practices in the protection of information systems from unauthorized actors and cyber-threats. The criteria of the cybersecurity evaluation is identified and analyzed for quality, strengths, weaknesses, and future applicability. Topics within the criteria include organizational operation, regulations and industrial standards compliance, service delivery to national customers, and the prevention and mitigation of IT system and security failure. This analysis determines the strengths and weaknesses, and makes recommendations for revising the cybersecurity policies within the United States Health and Human Services Department.

  14. Department

    African Journals Online (AJOL)

    USER

    2016-01-13

    Jan 13, 2016 ... The quality of planning and decision making in the ... Geographic Information Systems (GIS) tools and support systems should ... Techniques such as buffering were incorporated in the system to allow users to .... Water points.

  15. Regulation on control systems tests

    International Nuclear Information System (INIS)

    Grau, J.; Navarro, J.M.

    1978-01-01

    Requirements under regulation applicable to the testing of control systems and controlled equipments in the case of USA nuclear projects are examined. They are reviewed, in particular, the following standards and criteria: 10 Code of Federal Regulations 50, Appendix A, General Design Criteria 20 and 21; IEEE Standards 279 and 308; IEEE Standard 338; US Regulatory Guides 1.22 and 1.118.(J.E.de C.)

  16. US Department of Energy Automated Transportation Management System

    International Nuclear Information System (INIS)

    Portsmouth, J.H.

    1994-01-01

    The U.S. Department of Energy (DOE) Transportation Management Division (TMD) is responsible for managing its various programs via a diverse combination of Government-Owned/Contractor-Operated facilities. TMD is seeking to update it automation capabilities in capturing and processing DOE transportation information. TMD's Transportation Information Network (TIN) is an attempt to bring together transportation management, shipment tracking, research activities and software products in various stages of development. The TMD's Automated Transportation Management System (ATMS) proposes to assist the DOE and its contractors in performing their daily transportation management activities and to assist the DOE Environmental Management Division in its waste management responsibilities throughout the DOE complex. The ATMS system will center about the storage, handling and documentation involved in the environmental clean-up of DOE sites. Waste shipments will be moved to approved Treatment, Storage and Disposal (TSD) facilities and/or nuclear material repositories. An additional investment in shipping samples to analytical laboratories also involves packaging and documentation according to all applicable U.S. Department of Transportation (DOT) or International Air Transport Association (IATA) regulations. The most immediate goal of effectively managing DOE transportation management functions during the 1990's is an increase in automation capabilities of the DOE and its contractors. Subject-matter experts from various DOE site locations will be brought together to develop and refine these capabilities through the maximum use of computer applications. A major part of this effort will be the identification of the most economical modes of transportation and enhanced management reporting capabilities for transportation analysis. The ATMS system will also provide for increased strategic and shipment analysis during the 1990's and beyond in support of the DOE environmental mission

  17. Department

    African Journals Online (AJOL)

    USER

    2016-01-13

    Jan 13, 2016 ... component was developed as the backend with a front end developed using VB. ... The system proved that with user oriented GIS system it is possible to develop tools that can ..... as the graphical user interface (GUI) where.

  18. Depart

    African Journals Online (AJOL)

    USER

    2016-05-06

    May 6, 2016 ... examine the adaptation to water resource including water for domestic use, agricultural use, and ... the climate system (internal variability), or variations in ... as well as the duration and impact of such variability ... release of greenhouse gases are the major .... In areas of high altitudes (Jos plateau. (606m).

  19. How characteristic routines of clinical departments influence students' self-regulated learning: A grounded theory study.

    Science.gov (United States)

    Berkhout, J J; Slootweg, I A; Helmich, E; Teunissen, P W; van der Vleuten, C P M; Jaarsma, A D C

    2017-11-01

    In clerkships, students are expected to self-regulate their learning. How clinical departments and their routine approach on clerkships influences students' self-regulated learning (SRL) is unknown. This study explores how characteristic routines of clinical departments influence medical students' SRL. Six focus groups including 39 purposively sampled participants from one Dutch university were organized to study how characteristic routines of clinical departments influenced medical students' SRL from a constructivist paradigm, using grounded theory methodology. The focus groups were audio recorded, transcribed verbatim and were analyzed iteratively using constant comparison and open, axial and interpretive coding. Students described that clinical departments influenced their SRL through routines which affected the professional relationships they could engage in and affected their perception of a department's invested effort in them. Students' SRL in a clerkship can be supported by enabling them to engage others in their SRL and by having them feel that effort is invested in their learning. Our study gives a practical insight in how clinical departments influenced students' SRL. Clinical departments can affect students' motivation to engage in SRL, influence the variety of SRL strategies that students can use and how meaningful students perceive their SRL experiences to be.

  20. Radiation safety in the nuclear medicine department: impact of the UK Ionising Radiations Regulations

    International Nuclear Information System (INIS)

    Harding, L.K.

    1987-01-01

    The new 1985 regulations and guidance on radiation protection in the U.K. are discussed in relation to the needs for controlled areas in the nuclear medicine department and patient wards, admittance to hospital to comply with legislation, classification of workers, patient waiting rooms, handling flood sources, pregnancy and breast feeding. (U.K.)

  1. The Abbott School Construction Program: NJ Department of Education Proposed Facilities Regulations. Analysis of Preschool Issues

    Science.gov (United States)

    Ponessa, Joan; Boylan, Ellen

    2004-01-01

    This report on preschool facilities analyzes regulations proposed by the New Jersey Department of Education (NJDOE) to implement the Educational Facilities Construction and Financing Act. (EFCFA). EFCFA, which authorizes and governs New Jersey's public school construction program, was enacted in July 2000 to implement the State Supreme Court's…

  2. Expert Graphics System Research in the Department of the Navy.

    Science.gov (United States)

    Duff, Jon M.

    1987-01-01

    Presents current trends in the development of expert systems within the Department of the Navy, particularly research into expert graphics systems intended to support the Authoring Instructional Methods (AIM) research project. Defines artificial intelligence and expert systems. Discusses the operations and functions of the Navy's intelligent…

  3. 28 CFR 30.3 - What programs and activities of the Department are subject to these regulations?

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false What programs and activities of the Department are subject to these regulations? 30.3 Section 30.3 Judicial Administration DEPARTMENT OF JUSTICE... Department are subject to these regulations? The Attorney General publishes in the Federal Register a list of...

  4. United States Department of Energy Automated Transportation Management System

    International Nuclear Information System (INIS)

    Portsmouth, J.H.

    1992-01-01

    At the US Department of Energy (DOE) 80 transportation facilities, each contractor's transportation management operation has different internal and site specific procedures, and reports to a DOE regional Field Office Traffic Manager (FOTM). The DOE Transportation Management Program (TMP) has the responsibility to manage a transportation program for safe, efficient, and economical transportation of DOE-owned materials. The TMP develops and administers transportation/traffic operations management policies and programs for materials; including radioactive materials, other hazardous materials, hazardous substances, and hazardous wastes, pursuant to applicable federal regulations, such as the Code of Federal Register, Sections 40 and 49. Transportation management has become an increasingly critical primarily because of transportation issues regarding the shipment of radioactive materials and hazardous wastes that are frequently the focus of public concerns. A large shipments and requiring millions of business transactions necessitates the establishment of automated systems, programs, procedures, and controls to ensure that the transportation management process in being handled in a safe, efficient, and economical manner. As the mission of many DOE facilities changes from production of special nuclear materials for defense purposes to environmental restoration and waste management, the role of transportation management will become even more important to the safe and efficient movement of waste materials to prescribed locations. In support of this role, the Automated Transportation Management System (ATMS) was conceived to assist the DOE and its contractors in the performance of their day-to-day transportation management activities. The ATMS utilizes the latest in technology and will supply state-of-the-art automated transportation management for current and future DOE transportation requirements

  5. Lessons learned implementing environmental regulations at non-Department of Energy sites

    International Nuclear Information System (INIS)

    Craig, R.B.; Dippo, G.L.

    1991-01-01

    The Hazardous Waste Remedial Actions Program (HAZWRAP) has been involved in the implementation of environmental regulations at non-Department of Energy (DOE) facilities for > 5 years. If any common thread has been identified in working at these sites, it is that no two sites can be treated the same. Each site and its associated wastes, governing regulations, and environmental conditions are different. The list of technical lessons learned is long, and their applicability to other sites must be looked at for each specific case. That is far too large a task to undertake here. The most important lesson HAZWRAP learned is not technical. Implementing environmental regulations at non-DOE sites is not any different from implementing regulations or anything else done at DOE facilities. The key to success lies in quality, planning, and communication. Taking the time to implement a good quality program based on sound planning and open communication will ensure program success

  6. Reliability and validity of emergency department triage systems

    NARCIS (Netherlands)

    van der Wulp, I.

    2010-01-01

    Reliability and validity of triage systems is important because this can affect patient safety. In this thesis, these aspects of two emergency department (ED) triage systems were studied as well as methodological aspects in these types of studies. The consistency, reproducibility, and criterion

  7. 76 FR 11985 - Acquisition Regulation: Department of Energy Acquisition Regulation, Government Property

    Science.gov (United States)

    2011-03-04

    .... Comments by e-mail are encouraged. FOR FURTHER INFORMATION CONTACT: Helene Abbott at (202) 287-1593 or via e-mail: helene.abbott@hq.doe.gov . SUPPLEMENTARY INFORMATION: Background Section-by-Section Analysis... the Idaho National Lab and has been in use since the late 1990s. The PIDS system is used by both DOE...

  8. An integration of Emergency Department Information and Ambulance Systems.

    Science.gov (United States)

    Al-Harbi, Nada; El-Masri, Samir; Saddik, Basema

    2012-01-01

    In this paper we propose an Emergency Department Information System that will be integrated with the ambulance system to improve the communication, enhance the quality of provided emergency services and facilitate information sharing. The proposed system utilizes new advanced technologies such as mobile web services that overcome the problems of interoperability between different systems, HL7 and GPS. The system is unique in that it allows ambulance officers to locate the nearest specialized hospital and allows access to the patient's electronic health record as well as providing the hospital with required information to prepare for the incoming patient.

  9. 19 CFR 0.2 - All other CBP regulations issued under the authority of the Department of Homeland Security.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false All other CBP regulations issued under the authority of the Department of Homeland Security. 0.2 Section 0.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY TRANSFERRED OR DELEGATED AUTHORITY...

  10. 29 CFR 35.1 - What is the purpose of the Department of Labor (DOL) age discrimination regulations?

    Science.gov (United States)

    2010-07-01

    ... BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE DEPARTMENT OF LABOR General § 35.1 What is the purpose of the Department of Labor (DOL) age discrimination regulations... 29 Labor 1 2010-07-01 2010-07-01 true What is the purpose of the Department of Labor (DOL) age...

  11. 76 FR 72428 - Privacy Act of 1974; Department of Homeland Security/ALL-017 General Legal Records System of Records

    Science.gov (United States)

    2011-11-23

    ... http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT: For general questions and privacy issues... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0094] Privacy Act of 1974; Department of Homeland Security/ALL--017 General Legal Records System of Records AGENCY: Privacy...

  12. Low compliance with a validated system for emergency department triage

    DEFF Research Database (Denmark)

    Christensen, Dorthea; Jensen, Nanna Martin; Maaløe, Rikke

    2011-01-01

    Bispebjerg Hospital has introduced a triage system at the Emergency Department (ED) based on "primary criteria" and a physiological scoring system named the Bispebjerg Early Warning Score (BEWS). A BEWS is calculated on the basis of five vital signs which are accessible bedside. Patients who have...... a "primary criterion" or a BEWS = 5 are presumed to be critically ill or severely injured and should be received by a multidisciplinary team, termed the Emergency Call (EC) and Trauma Call (TC), respectively. The aim of this study was to examine compliance with this triage system at Bispebjerg Hospital....

  13. Analysis of the Portuguese building regulation system

    OpenAIRE

    Costa Branco De Oliveira Pedro, J.A.; Meijer, F.M.; Visscher, H.J.

    2008-01-01

    The Portuguese building regulation system has undergone significant changes in the last 20 years. Almost all building regulations presently in force were approved during that period. Some of those building regulations resulted from the transposition of European Directives. Other building regulations were changed due to improvements in the scientific knowledge. The changes in the building control system were mainly driven by an adaptation to more pressing circumstances of practice. The lack...

  14. The assessment on impact of essential drugs policy on primary health care system in rural areas of Shandong Province policy and regulation division of the Health Department of Shandong Province.

    Science.gov (United States)

    Li, Zhuge; Shu, Defeng; Xia, Mei; Gao, Dehai; Lu, Dan; Huang, Ning; Tian, Xiaoqing; An, Limei; Li, Shixue; Li, Sheng

    2015-01-01

    At present, China has achieved an initial establishment and gradual implementation of a framework for national essential drugs policy. With the further implementation of the national essential drugs policy, it is not clear how the policy works, whether it achieves the original intention of essential drugs policy, and what impact essential drugs policy exerts on the primary health care system. In view of it, we conducted a field research on sample areas of Shandong Province to understand the conditions of the implementation of the essential drugs policy in Shandong Province. From three perspectives of medical institutions, patients and medical staff, this thesis analyzes the impact of essential drugs policy on village-level and township-level health service system, summarizes the effectiveness of implementing essential drugs policy, discovers the problems of various aspects and conducts an in-depth analysis of the causes, and puts forward feasible suggestions to provide reference for improving the essential drugs policy. The assessment results show that the implementation of essential drugs policy in Shandong Province has played a positive role in promoting the sound development of the primary health care system, changed the situation of covering hospital expenses with medicine revenue in the past, contributed to the return of medical institutions to public welfare, and reduced the patient's economic burden of disease. But there emerge many problems as follows: impact on the doctor's diagnosis and treatment due to incompleteness of drug types, and distribution not in place, patient loss and operational difficulty of village clinic. Thus, this thesis makes recommendations of drugs catalog formulation, drug procurement, sales and use, and meanwhile points out that the supporting financial compensation policy and performance appraisal policy and other measures in place are a prerequisite for a positive role of essential drugs policy.

  15. Operational Management System for Regulated Water Systems

    Science.gov (United States)

    van Loenen, A.; van Dijk, M.; van Verseveld, W.; Berger, H.

    2012-04-01

    Most of the Dutch large rivers, canals and lakes are controlled by the Dutch water authorities. The main reasons concern safety, navigation and fresh water supply. Historically the separate water bodies have been controlled locally. For optimizating management of these water systems an integrated approach was required. Presented is a platform which integrates data from all control objects for monitoring and control purposes. The Operational Management System for Regulated Water Systems (IWP) is an implementation of Delft-FEWS which supports operational control of water systems and actively gives advice. One of the main characteristics of IWP is that is real-time collects, transforms and presents different types of data, which all add to the operational water management. Next to that, hydrodynamic models and intelligent decision support tools are added to support the water managers during their daily control activities. An important advantage of IWP is that it uses the Delft-FEWS framework, therefore processes like central data collection, transformations, data processing and presentation are simply configured. At all control locations the same information is readily available. The operational water management itself gains from this information, but it can also contribute to cost efficiency (no unnecessary pumping), better use of available storage and advise during (water polution) calamities.

  16. Simulation of Darlington shutdown and regulation systems

    International Nuclear Information System (INIS)

    1986-10-01

    This report describes the development of a simulation of the Darlington Nuclear Generating Station shutdown and regulating systems, DARSIM. The DARSIM program simulates the spatial neutron dynamics, the regulation of the reactor power, and Shutdown System 1, SDS1, and Shutdown System 2, SDS2, software. The DARSIM program operates in the interactive simulation (INSIM) program environment

  17. Department of Energy security program needs effective information systems

    International Nuclear Information System (INIS)

    1991-10-01

    Although security is an important, nearly billion-dollar-a-year function in the Department of Energy (DOE), key information systems that hold important data about security weaknesses and incidents have limited analytical capabilities and contain unreliable information. The resultant difficulty in identifying patterns and trends reduces managers' ability to ensure the effectiveness of the security program. Resources are also wasted because DOE has deployed incompatible systems that are unable to electronically share or transfer data, often forcing employees to manually re-enter data that are already stored in computers elsewhere. Finally, continuing data problems with other important security information systems, such as those used to track security clearances and classified documents, indicate that information system deficiencies are extensive. A major reason for these problems is that DOE has not done a comprehensive, strategic assessment of its information and information technology needs of the security program. DOE's efforts are fragmented because it has not assigned to any organization the leadership responsibility to determine security information needs and to plan and manage security information resources Department-wide. This paper reports that a number of changes are needed to correct these problems and take advantage of information technology to help strengthen the security program

  18. PHITS code improvements by Regulatory Standard and Research Department Secretariat of Nuclear Regulation Authority

    International Nuclear Information System (INIS)

    Goko, Shinji

    2017-01-01

    As for the safety analysis to be carried out when a nuclear power company applies for installation permission of facility or equipment, business license, design approval etc., the Regulatory Standard and Research Department Secretariat of Nuclear Regulation Authority continuously conducts safety research for the introduction of various technologies and their improvement in order to evaluate the adequacy of this safety analysis. In the field of the shielding analysis of nuclear fuel transportation materials, this group improved the code to make PHITS applicable to this field, and has been promoting the improvement as a tool used for regulations since FY2013. This paper introduced the history and progress of this safety research. PHITS 2.88, which is the latest version as of November 2016, was equipped with the automatic generation function of variance reduction parameters [T-WWG] etc., and developed as the tool equipped with many effective functions in practical application to nuclear power regulations. In addition, this group conducted the verification analysis against nuclear fuel packages, which showed a good agreement with the analysis by MCNP, which is extensively used worldwide and abundant in actual results. It also shows a relatively good agreement with the measured values, when considering differences in analysis and measurement. (A.O.)

  19. Quality and safety implications of emergency department information systems.

    Science.gov (United States)

    Farley, Heather L; Baumlin, Kevin M; Hamedani, Azita G; Cheung, Dickson S; Edwards, Michael R; Fuller, Drew C; Genes, Nicholas; Griffey, Richard T; Kelly, John J; McClay, James C; Nielson, Jeff; Phelan, Michael P; Shapiro, Jason S; Stone-Griffith, Suzanne; Pines, Jesse M

    2013-10-01

    The Health Information Technology for Economic and Clinical Health Act of 2009 and the Centers for Medicare & Medicaid Services "meaningful use" incentive programs, in tandem with the boundless additional requirements for detailed reporting of quality metrics, have galvanized hospital efforts to implement hospital-based electronic health records. As such, emergency department information systems (EDISs) are an important and unique component of most hospitals' electronic health records. System functionality varies greatly and affects physician decisionmaking, clinician workflow, communication, and, ultimately, the overall quality of care and patient safety. This article is a joint effort by members of the Quality Improvement and Patient Safety Section and the Informatics Section of the American College of Emergency Physicians. The aim of this effort is to examine the benefits and potential threats to quality and patient safety that could result from the choice of a particular EDIS, its implementation and optimization, and the hospital's or physician group's approach to continuous improvement of the EDIS. Specifically, we explored the following areas of potential EDIS safety concerns: communication failure, wrong order-wrong patient errors, poor data display, and alert fatigue. Case studies are presented that illustrate the potential harm that could befall patients from an inferior EDIS product or suboptimal execution of such a product in the clinical environment. The authors have developed 7 recommendations to improve patient safety with respect to the deployment of EDISs. These include ensuring that emergency providers actively participate in selection of the EDIS product, in the design of processes related to EDIS implementation and optimization, and in the monitoring of the system's ongoing success or failure. Our recommendations apply to emergency departments using any type of EDIS: custom-developed systems, best-of-breed vendor systems, or enterprise systems

  20. 49 CFR 17.3 - What programs and activities of the Department are subject to these regulations?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What programs and activities of the Department are subject to these regulations? 17.3 Section 17.3 Transportation Office of the Secretary of Transportation INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF TRANSPORTATION PROGRAMS AND ACTIVITIES § 17.3 What programs and activities...

  1. 19 CFR 0.1 - Customs revenue function regulations issued under the authority of the Departments of the...

    Science.gov (United States)

    2010-04-01

    ... the authority of the Departments of the Treasury and Homeland Security. 0.1 Section 0.1 Customs Duties... TRANSFERRED OR DELEGATED AUTHORITY § 0.1 Customs revenue function regulations issued under the authority of... authority to prescribe all CBP regulations relating to customs revenue functions, except that the Secretary...

  2. U. S. Department of Energy Aerial Measuring Systems

    Energy Technology Data Exchange (ETDEWEB)

    J. J. Lease

    1998-10-01

    The Aerial Measuring Systems (AMS) is an aerial surveillance system. This system consists of remote sensing equipment to include radiation detectors; multispectral, thermal, radar, and laser scanners; precision cameras; and electronic imaging and still video systems. This equipment, in varying combinations, is mounted in an airplane or helicopter and flown at different heights in specific patterns to gather various types of data. This system is a key element in the US Department of Energy's (DOE) national emergency response assets. The mission of the AMS program is twofold--first, to respond to emergencies involving radioactive materials by conducting aerial surveys to rapidly track and map the contamination that may exist over a large ground area and second, to conduct routinely scheduled, aerial surveys for environmental monitoring and compliance purposes through the use of credible science and technology. The AMS program evolved from an early program, begun by a predecessor to the DOE--the Atomic Energy Commission--to map the radiation that may have existed within and around the terrestrial environments of DOE facilities, which produced, used, or stored radioactive materials.

  3. U. S. Department of Energy Aerial Measuring Systems

    International Nuclear Information System (INIS)

    Lease, J.J.

    1998-01-01

    The Aerial Measuring Systems (AMS) is an aerial surveillance system. This system consists of remote sensing equipment to include radiation detectors; multispectral, thermal, radar, and laser scanners; precision cameras; and electronic imaging and still video systems. This equipment, in varying combinations, is mounted in an airplane or helicopter and flown at different heights in specific patterns to gather various types of data. This system is a key element in the US Department of Energy's (DOE) national emergency response assets. The mission of the AMS program is twofold--first, to respond to emergencies involving radioactive materials by conducting aerial surveys to rapidly track and map the contamination that may exist over a large ground area and second, to conduct routinely scheduled, aerial surveys for environmental monitoring and compliance purposes through the use of credible science and technology. The AMS program evolved from an early program, begun by a predecessor to the DOE--the Atomic Energy Commission--to map the radiation that may have existed within and around the terrestrial environments of DOE facilities, which produced, used, or stored radioactive materials

  4. Seed regulations and local seed systems

    NARCIS (Netherlands)

    Louwaars, N.

    2000-01-01

    Seed regulations have been introduced in most countries based on the development of formal seed production. Concerns about seed quality and about the varietal identity of the seeds have commonly led to seed laws. However, formal regulations are often inappropriate for informal seed systems, which

  5. Organisational culture at the Radiation and Nuclear Safety Authority of Finland's department of Nuclear Reactor Regulation

    International Nuclear Information System (INIS)

    Reiman, T.; Norros, L.

    2001-03-01

    A case study to investigate the organisational culture of the regulatory authority was conducted at the Radiation and Nuclear Safety Authority of Finland's (STUK) Nuclear Reactor Regulation (YTO) - department. Organisational culture is defined as a pattern of shared basic assumptions, which are basically unconscious. Objectives of the study were to conceptualise and describe the main characteristics of YTO's organisational culture and to carry out a tentative core task analysis of the inspectors' work. A combination of quantitative and qualitative methods was used in the research. YTO's culture was identified as a hierarchy-focused culture with less emphasis on innovation or social support. However, the ideal values of the personnel emphasised also social support and goal setting. Ambiguous goals were felt by some personnel as increased uncertainty about the meaningfulness of one's job. Also a lack of feedback was mentioned. The core task analysis identified the critical functions of the regulatory practice. These functions specify the three roles of the regulatory authority, the expert role, the public role and the authority role. The culture must support the fulfilment of the requirements of all the three roles. Development needs in YTO's culture were identified and recommendations were made. (au)

  6. Expert system aids transport regulation users

    International Nuclear Information System (INIS)

    Cheshire, R.D.; Straw, R.J.

    1990-01-01

    During late 1984 the IAEA Regulations were identified as an area of application for an expert system adviser which could offer many advantages. Over the following year some simple tests were carried out to examine its feasibility, but TRANAID did not get underway until 1986 when British Nuclear Fuels (BNFL) Corporate Management services were engaged on the product. By this time a greater choice of suitable software, in the form of expert system shells, had become available. After a number of trial systems the shell Leonardo was finally adopted for the final system. In order for TRANAID to emulate the expert it was necessary to spend time extracting and documenting the expert knowledge. This was a matter of investigating how the regulations are used and was achieved by a series of meetings including opportunity for the computer specialists to interview the regulations experts. There are several benefits in having an expert system advisor in this area. It is useful to both experienced and inexperienced users of regulations. For those who are learning to use the regulations it is an excellent training aid. For those who know the regulations but use them infrequently it can save time and provide a valuable reassurance. The adviser has enabled the expert user's know how to be captured and to be made widely available to those with less experience. (author)

  7. An Evaluation of the Cybersecurity Policies for the United States Health & Human Services Department: Criteria, Regulations, and Improvements

    OpenAIRE

    Derek Mohammed; Ronda Mariani

    2014-01-01

    This paper examines the criteria necessary for the evaluation of the cybersecurity policies for the United States Health and Human Services Department of the Federal Government. The overall purpose of cybersecurity policies and procedures is supported through compliance with Federal mandated regulation and standards, which serve to protect the organizational services and goals of the United States Health and Human Services Department, and to promote the best possible security practices in the...

  8. [Establishing a quality management system according to DIN EN ISO 9001:2000 in an academic radiological department].

    Science.gov (United States)

    Adam, G; Lorenzen, J; Krupski, G; Schackmann, R; Steiner, P; Reuter, H; Paschen, U

    2003-02-01

    Establishing a quality management (QM) system according the guidelines of DIN EN ISO 9001:2000 in an academic radiological department. To fulfill the requirements of an academic radiological department a quality management system according the guidelines of DIN EN ISO 9001 : 2000 has been established within one year. All important educational, research and patient care issues have been discussed in plenary sessions of all employees of the department twice a week. All core processes of the department have been documented as process instructions and standard operation procedures. Supported by the staff unit "quality assurance" of the university hospital, the QM system has been established during one year. Assisted by all parties of the department, obliging regulations have been established which are well accepted in the daily routine clinical work but also in research and education. The implementation of the QM system caused an additional work load. However, spreading the work load by a consequent responsibility assignment, it could be reduced effectively. The implementation of a QM system within the daily routine work of an academic radiological department is feasible. It allows the installation of generally accepted rules which regulate the principal tasks of research and education, and patient care.

  9. Quality assurance procedures for the IAEA Department of Safeguards Twin Minolta Camera Surveillance System

    International Nuclear Information System (INIS)

    Geoffrion, R.R.; Bussolini, P.L.; Stark, W.A.; Ahlquist, A.J.; Sanders, K.E.; Rubinstein, G.

    1986-01-01

    The International Atomic Energy Agency (IAEA) safeguards program provides assurance to the international community that nations are complying with nuclear safeguards treaties. In one aspect of the program, the Department of Safeguards has developed a twin Minolta camera photo surveillance systems program to assure itself and the international community that material handling is accomplished according to safeguards treaty regulations. The camera systems are positioned in strategic locations in facilities such that objective evidence can be obtained for material transactions. The films are then processed, reviewed, and used to substantiate the conclusions that nuclear material has not been diverted. Procedures have been developed to document and aid in: 1) the performance of activities involved in positioning of the camera system; 2) installation of the systems; 3) review and use of the film taken from the cameras

  10. 77 FR 51496 - Federal Acquisition Regulation; Basic Safeguarding of Contractor Information Systems

    Science.gov (United States)

    2012-08-24

    ... Federal Acquisition Regulation; Basic Safeguarding of Contractor Information Systems AGENCY: Department of... Acquisition Regulation (FAR) to add a new subpart and contract clause for the basic safeguarding of contractor... information) that will be resident on or transiting through contractor information systems. DATES: Interested...

  11. On output regulation for linear systems

    NARCIS (Netherlands)

    Saberi, Ali; Stoorvogel, Antonie Arij; Sannuti, Peddapullaiah

    For both continuous- and discrete-time systems, we revisit the output regulation problem for linear systems. We generalize the problem formulation in order • to expand the class of reference or disturbance signals, • to utilize the derivative or feedforward information of reference signals whenever

  12. Signal-regulated systems and networks

    CSIR Research Space (South Africa)

    Van Zyl, TL

    2010-07-01

    Full Text Available The article presents the use of signal regulatory networks (SRNs), a biologically inspired model based on gene regulatory networks. SRNs are a way of understanding a class of self-organizing IT systems, signal-regulated systems (SRSs). This article...

  13. Organisational culture at the Radiation and Nuclear Safety Authority of Finland's Nuclear Reactor Regulation department

    International Nuclear Information System (INIS)

    Reiman, T.

    2001-01-01

    A case study to investigate the organisational culture of the regulatory authority was conducted at the Radiation and Nuclear Safety Authority of Finland's (STUK) Nuclear Reactor Regulation (YTO) department. Organisational culture is defined as a pattern of shared basic assumptions, which are basically unconscious. Objectives of the study were to conceptualise and describe the main characteristics of YTO's organisational culture and to carry out a tentative core task analysis of the inspectors' work. A combination of quantitative and qualitative methods was used in the research. In the first phase of the research, an organisational culture survey (FOCUS) was administered. It is base on a theory according to which organisations can be categorised into four main culture types, support-, innovation, goal- and rule-culture. It was tailored to better fit this kind of organisation on the basis of document analysis and preliminary interviews. Data was factor analysed and summated scales were formed. YTO's culture was identified as a hierarchy-focused (rule) culture with less emphasis on innovation, support or goals. However, the ideal values of the personnel emphasised also social support and goal setting. Ambiguous goals were felt by some personnel as increased uncertainty about the meaningfulness of one's job. Also a lack of feedback was mentioned as a weakness in YTO's culture. In the second phase of the research, a development workshop was carried out. The themes of the workshop were identified on the basis of the results of the first phase. Main targets for development that were identified in the workshop were human resources, goal setting and knowledge management. The ideal values of the personnel emphasised support and goal cultures. (orig.)

  14. 77 FR 44673 - Meeting of the Department of Justice National Motor Vehicle Title Information System Federal...

    Science.gov (United States)

    2012-07-30

    ... Department of Justice National Motor Vehicle Title Information System Federal Advisory Committee AGENCY... a meeting of Department of Justice's (DOJ's) National Motor Vehicle Title Information System (NMVTIS...., Washington, DC 20531. FOR FURTHER INFORMATION CONTACT: Todd Brighton, Designated Federal Employee (DFE...

  15. The Abbott School Construction Program: Report on the NJ Department of Education Proposed Regulations on Long-Range Facilities Plans

    Science.gov (United States)

    Ponessa, Joan

    2004-01-01

    This report on Long Range Facilities Plans (LRFPs) analyzes regulations proposed by the New Jersey Department of Education (NJDOE) to implement the Educational Facilities Construction and Financing Act. (EFCFA). EFCFA, which authorizes and governs New Jersey's public school construction program, was enacted in July 2000 to implement the State…

  16. 15 CFR 19.2 - Why has the Commerce Department issuing these regulations and what do they cover?

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Why has the Commerce Department issuing these regulations and what do they cover? 19.2 Section 19.2 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION General Provisions § 19.2 Why has the Commerce...

  17. Role of Osmolytes in Regulating Immune System.

    Science.gov (United States)

    Kumar, Tarun; Yadav, Manisha; Singh, Laishram Rajendrakumar

    2016-01-01

    The immune system has evolved to protect the host organism from diverse range of pathogenic microbes that are themselves constantly evolving. It is a complex network of cells, humoral factors, chemokines and cytokines. Dysregulation of immune system results in various kinds of immunological disorders. There are several external agents which govern the regulation of immune system. Recent studies have indicated the role of osmolytes in regulation of various immunological processes such as Ag-Ab interaction, Ig assembly, Ag presentation etc. In this present review, we have systematically discussed the role of osmolytes involved in regulation of several key immunological processes. Osmolytes are involved in the regulation of several key immunological processes such as immunoglobulin assembly and folding, immune cells proliferation, regulation of immune cells function, Ag-Ab interaction, antigen presentation, inflammatory response and protection against photo-immunosuppression. Hence, osmolytes and their transporters might be used as potential drug and drug targets respectively. This review is therefore designed to help clinicians in development of osmolyte based therapeutic strategies in the treatment of various immunological disorders. Appropriate future perspectives have also been included.

  18. 75 FR 49357 - United States Department of Agriculture Research Misconduct Regulations for Extramural Research

    Science.gov (United States)

    2010-08-13

    ... DEPARTMENT OF AGRICULTURE Office of the Chief Financial Officer 7 CFR Part 3022 RIN 0524-AA34...: Office of the Chief Financial Officer, USDA. ACTION: Final rule. SUMMARY: The Office of the Chief.... Holladay, Acting Chief Financial Officer. Thomas J. Vilsack, Secretary, U.S. Department of Agriculture. [FR...

  19. Definition of a prospective payment system to reimburse emergency departments.

    Science.gov (United States)

    Levaggi, Rosella; Montefiori, Marcello

    2013-10-11

    Payers are increasingly turning to Prospective Payment Systems (PPSs) because they incentivize efficiency, but their application to emergency departments (EDs) is difficult because of the high level of uncertainty and variability in the cost of treating each patient.To the best of our knowledge, our work represents the first attempt at defining a PPS for this part of hospital activity. Data were specifically collected for this study and relate to 1011 patients who were triaged at an ED of a major Italian hospital, during 1 week in December 2010.The cost for each patient was analytically estimated by adding up several components: 1) physician and other staff costs that were imputed on the basis of the time each physician claimed to have spent treating the patient; 2) the cost for each test/treatment each patient actually underwent; 3) overhead costs, shared among patients using the time elapsed between first examination and discharge from the ED. The distribution of costs by triage code shows that, although the average cost increases across the four triage groups, the variance within each code is quite high. The maximum cost for a yellow code is €1074.7, compared with €680 for red, the most serious code. Using cluster analysis, the red code cluster is enveloped by yellow, and their costs are therefore indistinguishable, while green codes span all cost groups. This suggests that triage code alone is not a good proxy for the patient cost, and that other cost drivers need to be included. Crude triage codes cannot be used to define PPSs because they are not sufficiently correlated with costs and are characterized by large variances. However, if combined with other information, such as the number of laboratory and non-laboratory tests/examinations, it is possible to define cost groups that are sufficiently homogeneous to be reimbursed prospectively. This should discourage strategic behavior and allow the ED to break even or create profits, which can be reinvested to

  20. Market research for Idaho Transportation Department linear referencing system.

    Science.gov (United States)

    2009-09-02

    For over 30 years, the Idaho Transportation Department (ITD) has had an LRS called MACS : (MilePoint And Coded Segment), which is being implemented on a mainframe using a : COBOL/CICS platform. As ITD began embracing newer technologies and moving tow...

  1. Intraocular pressure reduction and regulation system

    Science.gov (United States)

    Baehr, E. F.; Burnett, J. E.; Felder, S. F.; Mcgannon, W. J.

    1979-01-01

    An intraocular pressure reduction and regulation system is described and data are presented covering performance in: (1) reducing intraocular pressure to a preselected value, (2) maintaining a set minimum intraocular pressure, and (3) reducing the dynamic increases in intraocular pressure resulting from external loads applied to the eye.

  2. DEPARTMENT OF ENERGY: Views on Proposed Civil Penalties, Security Oversight, and External Safety Regulation Legislation

    National Research Council Canada - National Science Library

    Jones, Gary

    2000-01-01

    This report provides the General Accounting Office's views on three bills designed to improve worker and nuclear facility safety and health as well as to enhance security for the Department of Energy (DOE...

  3. Shigella Iron Acquisition Systems and their Regulation.

    Science.gov (United States)

    Wei, Yahan; Murphy, Erin R

    2016-01-01

    Survival of Shigella within the host is strictly dependent on the ability of the pathogen to acquire essential nutrients, such as iron. As an innate immune defense against invading pathogens, the level of bio-available iron within the human host is maintained at exceeding low levels, by sequestration of the element within heme and other host iron-binding compounds. In response to sequestration mediated iron limitation, Shigella produce multiple iron-uptake systems that each function to facilitate the utilization of a specific host-associated source of nutrient iron. As a mechanism to balance the essential need for iron and the toxicity of the element when in excess, the production of bacterial iron acquisition systems is tightly regulated by a variety of molecular mechanisms. This review summarizes the current state of knowledge on the iron-uptake systems produced by Shigella species, their distribution within the genus, and the molecular mechanisms that regulate their production.

  4. Self-regulating energy storage system

    Energy Technology Data Exchange (ETDEWEB)

    Eisenhaure, D.B.; Downer, J.R.; Bliamptis, T.E.; Oberbeck, G.A.; Hendrie, S.D.

    1986-10-14

    This patent describes a self-regulating energy storage system which consists of: an a.c. motor/generator including a rotor; a flywheel attached to the motor/generator; means for monitoring the position of the motor/generator rotor; means for resolving current to and from the motor/generator; a pulse width modulated bidirectional inverter interconnecting the motor/generator with a power supply bus having a voltage to be regulated; a summing circuit for determining differences between a reference voltage and the voltage on the power supply bus to be regulated; and a pulse width modulation switch control responsive to the summing circuit, to the means for monitoring, and to the means for resolving.

  5. 75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

    Science.gov (United States)

    2010-10-25

    ... Accounting Service or Missile Defense Agency. (2) For DoD, the authority to acknowledge receipt or reject... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 219 and 252 [DFARS Case 2009-D002] Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting...

  6. 76 FR 2761 - Proposed Information Collection (Department of Veterans Affairs Acquisition Regulations Clause...

    Science.gov (United States)

    2011-01-14

    ... contracts for the acquisition of non-personal health care services. It requires the bidder/offeror prior to... Regulation clause 52.207-3, Right of First Refusal of Employment. Affected Public: Business or other for...

  7. 76 FR 16043 - Agency Information Collection (Department of Veterans Affairs Acquisition Regulations Clause 852...

    Science.gov (United States)

    2011-03-22

    ... contracts for the acquisition of non-personal health care services. It requires the bidder/offeror prior to... Acquisition Regulation Clause 52.207-3, Right of First Refusal of Employment. An agency may not conduct or...

  8. 77 FR 27263 - Computer Matching Between the Selective Service System and the Department of Education

    Science.gov (United States)

    2012-05-09

    ... SELECTIVE SERVICE SYSTEM Computer Matching Between the Selective Service System and the Department of Education AGENCY: Selective Service System. Action: Notice. In accordance with the Privacy Act of... of Participating Agencies The Selective Service System (SSS) and the Department of Education (ED). 2...

  9. US Department of Energy automated transportation management system

    International Nuclear Information System (INIS)

    Thomas, T.M.; Frost, D.M.; Lopez, C.A.

    1996-01-01

    The US Department of Energy (DOE) has approximately 80 facilities throughout the United States that specialize in either scientific research, engineering, technology, production, and/or waste management activities. These facilities can best be described as Government Owned, Contractor Operated (GOCO) sites, and vary in size from very small laboratories to large industrial plant type facilities. Each of these GOCO's have varying needs for transportation of materials into and/or out of their facility. Therefore, Traffic Management operations will differ from site to site due to size and the internal or site specific mission. The DOE Transportation Management Division (TMD) has the corporate responsibility to provide a well managed transportation management program for the safe, efficient, and economical transportation of all DOE-owned materials. To achieve this mission, TMD provides oversight, and when necessary, resources to assist in ensuring regulatory compliance in the packaging and shipment of DOE-owned materials. A large part of TMD's responsibility is to develop, administer, and provide policies and guidance concerning department-wide transportation and packaging operations. This responsibility includes overall Transportation Management policies and programs for the packaging and movement of all DOE materials, including radioactive materials, other hazardous materials/substances, and hazardous wastes. TMD formulates policies and guidance that assist the DOE Field Elements and GOCO's in meeting TMD's goal for safe, efficient and economical transportation. Considering there are at least 80 shipping and receiving sites, the challenge encountered by TMD has been the difficulty in managing such a diverse transportation community

  10. Spatial Structures and Regulation in Biological Systems

    DEFF Research Database (Denmark)

    Yde, Pernille

    , and the other is the spatial regulation of biological systems, here related to different aspects of the inflammatory response. All systems are studied using computational modelling and mathematical analysis. The first part of the thesis explores different protein aggregation scenarios. In Chapter 1, we consider...... a previously studied and very general aggregation model describing frangible linear filaments. This model is especially relevant for the growth of amyloid fibres, that have been related to a number of serious human diseases, and which are known to grow in an accelerated self-enhanced manner.We derive...... model of the tissue and show how coupled cells are able to function as an excitable medium and propagate waves of high cytokine concentration through the tissue. If the internal regulation in the cells is over-productive, the model predicts a continuous amplification of cytokines, which spans the entire...

  11. Application of United States Department of Transportation regulations to hazardous material and waste shipments on the Hanford site

    International Nuclear Information System (INIS)

    Burnside, M.E.

    1992-01-01

    All hazardous material and waste transported over roadways open to the public must be in compliance with the U.S. Department of Transportation (DOT) regulations. The DOT states that the hazardous material regulations (HMR) also apply to government-owned, contractor-operated (GOCO) transportation operations over any U.S. Department of Energy (DOE) site roadway where the public has free and unrestricted access. Hazardous material and waste in packages that do not meet DOT regulations must be transported on DOE site roadways in a manner that excludes the public and nonessential workers. At the DOE Richland Field Office (the Hanford Site), hazardous material and waste movements that do not meet DOT requirements are transported over public access roadways during off-peak hours with the roadways barricaded. These movements are accomplished using a transportation plan that involves the DOE, DOE contractors, and private utilities who operate on or near the Hanford Site. This method, which is used at the Hanford Site to comply with DOT regulations onsite, can be communicated to other DOE sites to provide a basis for achieving consistency in similar transportation operations. (author)

  12. Frontiers of environmental regulation: environmental management systems: a regulator`s perspective

    Energy Technology Data Exchange (ETDEWEB)

    Stone, M.J. [South Australian Dept. of Mines and Energy, Adelaide, SA (Australia)

    1996-12-31

    Leading edge companies throughout the world have embraced management systems to achieve optimal sustainable performance in the ever changing business environment of the 1990s. Given that the natural environment and environmental performance have become major issues affecting organizations, the need for integrating environmental management with all the other components of an organization`s overall management approach is now widely recognized. This paper is organized in five parts. The first explores recently released environmental standards, the interim environmental management systems (EMS) general guidelines standard AS/NZS ISO 14004 (Int) and identifies how this has dealt with the regulator/community/company interface. The second identifies company requirements for addressing environmental issues. The third, considers regulatory theory to identify current requirements for an effective regulatory system and how this can interface with a company`s EMS. These form the basis in the fourth section for identifying some opportunities which occur at the company/ regulator interface. The fifth and final section draws a number of conclusions about the current frontiers of environmental regulation. The coincidence of the requirements of a regulatory framework with the areas of interface between what is referred to in the draft International Standard for EMS as `Interested Parties`, the regulators and community, are identified. (author). 1 tab., 2 figs., 20 refs.

  13. Operating experience review - Ventilation systems at Department of Energy Facilities

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    The Office of Special Projects (DP-35), formerly Office of Self-Assessment (DP-9), analyzed occurrences caused by problems with equipment and material and recommended the following systems for an in-depth study: (1) Selective Alpha Air Monitor (SAAM), (2) Emergency Diesel Generator, (3) Ventilation System, (4) Fire Alarm System. Further, DP-35 conducted an in-depth review of the problems associated with SAAM and with diesel generators, and made several recommendations. This study focusses on ventilation system. The intent was to determine the causes for the events related to these system that were reported in the Occurrence Reporting and Processing System (ORPS), to identify components that failed, and to provide technical information from the commercial and nuclear industries on the design, operation, maintenance, and surveillance related to the system and its components. From these data, sites can develop a comprehensive program of maintenance management, including surveillance, to avoid similar occurrences, and to be in compliance with the following DOE orders.

  14. Systems Studies Department FY 78 activity report. Volume 2. Systems analysis

    International Nuclear Information System (INIS)

    Gold, T.S.

    1979-02-01

    The Systems Studies Department at Sandia Laboratories Livermore (SLL) has two primary responsibilities: to provide computational and mathematical services and to perform systems analysis studies. This document (Volume 2) describes the FY Systems Analysis highlights. The description is an unclassified overview of activities and is not complete or exhaustive. The objective of the systems analysis activities is to evaluate the relative value of alternative concepts and systems. SLL systems analysis activities reflect Sandia Laboratory programs and in 1978 consisted of study efforts in three areas: national security: evaluations of strategic, theater, and navy nuclear weapons issues; energy technology: particularly in support of Sandia's solar thermal programs; and nuclear fuel cycle physical security: a special project conducted for the Nuclear Regulatory Commission. Highlights of these activities are described in the following sections. 7 figures

  15. Summary of Research 2000, Department of Systems Management

    Science.gov (United States)

    2001-12-01

    de Ingenieria Aeroniutica, 1982 Master of Science in Management-March 2000 and Marcelo B. Rodrigues-Lieutenant Commander, Brazilian Navy B.S...Brazilian Naval Academy, 1983 Master of Science in Management-December 1999 and Mario Karpowicz-Major, Argentine Air Force B.S., Escuela de Ingenieria ...83 Analysis of the Company Officer Management Information System (COMIS) Performance Measurement Software at the United States Naval Academy

  16. Department of Defense Systems Engineering FY 2012 Annual Report

    Science.gov (United States)

    2013-03-01

    by the Utility Helicopter PMO, is utilizing the latest Defense Acquisition Guidelines and previously approved PEO AVN SEP examples to develop all...efforts. As a whole, all of PEO AVN Program Management Offices understand the importance of systems engineering. They stress the continued use of...established SE guidelines, practices and procedures throughout our acquisition processes. PEO AVN , working with the AMRDEC SE Division, has

  17. Vacuum Systems Consensus Guideline for Department of Energy Accelerator Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Casey,R.; Haas, E.; Hseuh, H-C.; Kane, S.; Lessard, E.; Sharma, S.; Collins, J.; Toter, W. F.; Olis, D. R.; Pushka, D. R.; Ladd, P.; Jobe, R. K.

    2008-09-09

    Vacuum vessels, including evacuated chambers and insulated jacketed dewars, can pose a potential hazard to equipment and personnel from collapse, rupture due to back-fill pressurization, or implosion due to vacuum window failure. It is therefore important to design and operate vacuum systems in accordance with applicable and sound engineering principles. 10 CFR 851 defines requirements for pressure systems that also apply to vacuum vessels subject to back-fill pressurization. Such vacuum vessels are potentially subject to the requirements of the American Society of Mechanical Engineers (ASME) Pressure Vessel Code Section VIII (hereafter referred to as the 'Code'). However, the scope of the Code excludes vessels with internal or external operating pressure that do not exceed 15 pounds per square inch gauge (psig). Therefore, the requirements of the Code do not apply to vacuum systems provided that adequate pressure relief assures that the maximum internal pressure within the vacuum vessel is limited to less than 15 psig from all credible pressure sources, including failure scenarios. Vacuum vessels that cannot be protected from pressurization exceeding 15 psig are subject to the requirements of the Code. 10 CFR 851, Appendix A, Part 4, Pressure Safety, Section C addresses vacuum system requirements for such cases as follows: (c) When national consensus codes are not applicable (because of pressure range, vessel geometry, use of special materials, etc.), contractors must implement measures to provide equivalent protection and ensure a level of safety greater than or equal to the level of protection afforded by the ASME or applicable state or local code. Measures must include the following: (1) Design drawings, sketches, and calculations must be reviewed and approved by a qualified independent design professional (i.e., professional engineer). Documented organizational peer review is acceptable. (2) Qualified personnel must be used to perform examinations

  18. UNITED STATES DEPARTMENT OF TRANSPORTATION GLOBAL POSITIONING SYSTEM (GPS) ADJACENT BAND COMPATIBILITY ASSESSMENT

    Science.gov (United States)

    2018-04-01

    The goal of the U.S. Department of Transportation (DOT) Global Positioning System (GPS) Adjacent Band Compatibility Assessment is to evaluate the maximum transmitted power levels of adjacent band radiofrequency (RF) systems that can be tolerated by G...

  19. 76 FR 38209 - Meeting of the Department of Justice's (DOJ's) National Motor Vehicle Title Information System...

    Science.gov (United States)

    2011-06-29

    ... Department of Justice's (DOJ's) National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... announcement of a meeting of DOJ's National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... FURTHER INFORMATION CONTACT: Alissa Huntoon, Designated Federal Employee (DFE), Bureau of Justice...

  20. A System Architecture and Migration Plan for the Student Services Department of the Marine Corps Institute

    National Research Council Canada - National Science Library

    Evers

    1997-01-01

    ... to a client server based, open information system for the Marine Corps Institute (MCI). The primary objective of this thesis is to develop the technology architecture required to support the information systems of the Student Services Department (SSD...

  1. 77 FR 40302 - Department of the Treasury Acquisition Regulation; Internet Payment Platform

    Science.gov (United States)

    2012-07-09

    ... payment, creating a standard set of electronic data to submit payment requests to the federal government... electronic invoicing and payment information system, and to change the definition of bureau to reflect the...-based electronic invoicing and payment system that processes vendor payment data electronically, either...

  2. Microprocessor system for temperature regulation and stabilization

    International Nuclear Information System (INIS)

    Nguyen Nhi Dien; Rodionov, K.G.

    1989-01-01

    Microprocessor based system for temperature regulation and stabilization of an operation external object is described. The system has the direct current amplifier working according to modulator-demodulator principle. The overal gain is 100, 1000, 2000. The maximum output signal is ±10 V. The power amplifier is a thyristor one and its line voltage is 220 V, 50 Hz. The output power is 0-2 kVA. The microcontroller has a remote display terminal. Data input is 8 and data output is one. Input and output voltage is ±(0-10) V. The preselection time for stabilization is within 1 s - 18 h. The program algorithm is given. 5 figs.; 1 tab

  3. Nuclear energy system department annual report. April 1, 2001 - March 31, 2002

    International Nuclear Information System (INIS)

    Nakajima, Hajime; Ohnuki, Akira; Kunii, Katsuhiko

    2003-03-01

    This report summarizes the research and development activities in the Department of Nuclear Energy System during the fiscal year of 2001 (April 1, 2001 - March 31, 2002). The Department has been organized from April 1998. The main research activity is aimed to build the basis of the development of future nuclear energy systems. The research activities of the Department cover basic nuclear data evaluation, conceptual design of a reduced-moderation water reactor, reactor physics experiments and development of the reactor analysis codes, experiment and analysis of thermal-hydrodynamics, energy system analysis and assessment, development of advanced materials for a reactor, lifetime reliability assessment on structural material, development of advanced nuclear fuel, design of a marine reactor and the research for a nuclear ship system. The maintenance and operation of reactor engineering facilities belonging to the Department are undertaken. The activities of the research committees to which the Department takes a role of secretariat are also summarized in this report. (author)

  4. 21 CFR 870.5900 - Thermal regulating system.

    Science.gov (United States)

    2010-04-01

    ... system. (a) Identification. A thermal regulating system is an external system consisting of a device that is placed in contact with the patient and a temperature controller for the device. The system is used... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Thermal regulating system. 870.5900 Section 870...

  5. Direct Student Loans: Overpayments during the Department of Education's Conversion to a New Payment System.

    Science.gov (United States)

    Joyner, Carlotta C.

    This report addresses concerns that the Department of Education may have erroneously made overpayments of as much as $400 million to schools participating in the William D. Ford Federal Direct Loan Program (FDLP) during the Department's conversion to a new computerized payment system. The investigation found that because the transition to the new…

  6. Department of Defense Quality Management Systems and ISO 9000:2000

    National Research Council Canada - National Science Library

    Lucius, Tommie

    2002-01-01

    ...) to the Department of Defense (DoD) quality management system (QMS) in procurement. In particular, the researcher will examine the new standard and its utility for DoD procurement, focusing on changes from the previous ISO 9000 series...

  7. Inventive activity of the Department of Metabolism Regulation of the Palladin Institute of Biochemistry of NAS of Ukraine

    Directory of Open Access Journals (Sweden)

    V. M. Danilova

    2016-12-01

    Full Text Available The article is devoted to the inventive activity of the Department of Metabolism Regulation of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and the research activities of its founder, academician of NAS of Ukraine M. F. Guly as well as his students and followers. It briefly tells about practical achievements of M. F. Guly which were as significant, immense and diverse as his scientific accomplishments. The paper analyses in detail the practical results of scientific research of his students and followers aimed to solve practical problems of medicine, food-processing, agriculture, and which are essentially a continuation of the ideas and projects of M. F. Guly.

  8. [Inventive activity of the Department of Metabolism Regulation of the Palladin Institute of Biochemistry of NAS of Ukraine].

    Science.gov (United States)

    Danilova, V M; Vynogradova, R P; Chernysh, I G; Petrenko, T M

    2016-01-01

    The article is devoted to the inventive activity of the Department of Metabolism Regulation of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and the research activities of its founder, academician of NAS of Ukraine M. F. Guly as well as his students and followers. It briefly tells about practical achievements of M. F. Guly which were as significant, immense and diverse as his scientific accomplishments. The paper analyses in detail the practical results of scientific research of his students and followers aimed to solve practical problems of medicine, food-processing, agriculture, and which are essentially a continuation of the ideas and projects of M. F. Guly.

  9. Power supply regulation systems installed in the Fermilab accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Hays, S.; Wolff, D.; Pfeffer, H.

    1991-11-01

    A variety of current and voltage regulation systems have been installed in the Fermilab large magnet system. The four major systems employ different methods to achieve the desired degree of regulation. The methods include computer control and feedback, adaptive learning, precision (10ppm) current monitoring, and the use of feed-forward signals. This paper will explain each method used and present the measured regulation of the above systems. Also an overview of planned upgrades and improvements will be presented.

  10. Safety regulation KTA 3901: Communication systems for nuclear power plants

    International Nuclear Information System (INIS)

    1981-01-01

    The regulation applies to communication systems in stationary nuclear power plants with at least one power plant unit, i.e. alarm systems, staff locator systems, communicators, and systems for external communication. The regulation determines the type and extent of staff communication systems as well as the demands to be made on layout, installation, operating systems, and testing of communication systems for nuclear power plants. (orig./HP) [de

  11. Nuclear energy system department annual report. April 1, 1999 - March 31, 2000

    International Nuclear Information System (INIS)

    2001-03-01

    This report summarizes the research and development activities in the Department of Nuclear Energy System during the fiscal year of 1999 (April 1, 1999 - March 31, 2000). The Department has been organized from April 1998. The main research activity is aimed to build the basis of the development of a future nuclear energy system. The research activities of the fiscal year cover basic nuclear and atomic and molecular data evaluation, conceptual design of a reduced-moderation water reactor, reactor physics experiments and development of the reactor analysis codes, experiment and analysis of thermal-hydrodynamics, development of advanced materials for a reactor, lifetime reliability assessment on structural material, development of advanced nuclear fuel, design of a marine reactor and the research for a nuclear ship system. The maintenance and operation of reactor engineering facilities belonging to the Department are undertaken. The activities of the research committee to which the Department takes a role of secretariat are also summarized in this report. (author)

  12. Information Processing in Auto-regulated Systems

    Directory of Open Access Journals (Sweden)

    Karl Javorszky

    2003-06-01

    Full Text Available Abstract: We present a model of information processing which is based on two concurrent ways of describing the world, where a description in one of the languages limits the possibilities for realisations in the other language. The two describing dimensions appear in our common sense as dichotomies of perspectives: subjective - objective; diversity - similarity; individual - collective. We abstract from the subjective connotations and treat the test theoretical case of an interval on which several concurrent categories can be introduced. We investigate multidimensional partitions as potential carriers of information and compare their efficiency to that of sequenced carriers. We regard the same assembly once as a contemporary collection, once as a longitudinal sequence and find promising inroads towards understanding information processing by auto-regulated systems. Information is understood to point out that what is the case from among alternatives, which could be the case. We have translated these ideas into logical operations on the set of natural numbers and have found two equivalence points on N where matches between sequential and commutative ways of presenting a state of the world can agree in a stable fashion: a flip-flop mechanism is envisioned. By following this new approach, a mathematical treatment of some poignant biomathematical problems is allowed. Also, the concepts presented in this treatise may well have relevance and applications within the information processing and the theory of language fields.

  13. Emergency department crowding in Singapore: Insights from a systems thinking approach.

    Science.gov (United States)

    Schoenenberger, Lukas K; Bayer, Steffen; Ansah, John P; Matchar, David B; Mohanavalli, Rajagopal L; Lam, Sean Sw; Ong, Marcus Eh

    2016-01-01

    Emergency Department crowding is a serious and international health care problem that seems to be resistant to most well intended but often reductionist policy approaches. In this study, we examine Emergency Department crowding in Singapore from a systems thinking perspective using causal loop diagramming to visualize the systemic structure underlying this complex phenomenon. Furthermore, we evaluate the relative impact of three different policies in reducing Emergency Department crowding in Singapore: introduction of geriatric emergency medicine, expansion of emergency medicine training, and implementation of enhanced primary care. The construction of the qualitative causal loop diagram is based on consultations with Emergency Department experts, direct observation, and a thorough literature review. For the purpose of policy analysis, a novel approach, the path analysis, is applied. The path analysis revealed that both the introduction of geriatric emergency medicine and the expansion of emergency medicine training may be associated with undesirable consequences contributing to Emergency Department crowding. In contrast, enhancing primary care was found to be germane in reducing Emergency Department crowding; in addition, it has apparently no negative side effects, considering the boundary of the model created. Causal loop diagramming was a powerful tool for eliciting the systemic structure of Emergency Department crowding in Singapore. Additionally, the developed model was valuable in testing different policy options.

  14. A computerized faculty time-management system in an academic family medicine department.

    Science.gov (United States)

    Daugird, Allen J; Arndt, Jane E; Olson, P Richard

    2003-02-01

    The authors describe the development, implementation, and evaluation of a computerized faculty time-management system (FTMS) in the Department of Family Medicine at the University of North Carolina-Chapel Hill. The FTMS is presented as an integrated set of computerized spreadsheets used annually to allocate faculty time across all mission activities of the department. It was first implemented in 1996 and has been continuously developed since then. An iterative approach has been used to gain consensus among faculty about time resources needed for various tasks of all missions of the department. These time-resource assumptions are used in the computerized system. Faculty time is allocated annually by the department vice chair in negotiation with individual faculty, making sure that the activities planned do not exceed the work time each faculty member has available for the year. During this process, faculty preferences are balanced against department aggregate needs to meet mission commitments and obligations. The authors describe how the computerized FTMS is used for faculty time management and career development, department planning, budget planning, clinical scheduling, and mission cost accounting. They also describe barriers and potential abuses and the challenge of building an organizational culture willing to discuss faculty time openly and committed to developing a system perceived as fair and accurate. The spreadsheet file is available free from the authors for use in other departments.

  15. A General Water Resources Regulation Software System in China

    Science.gov (United States)

    LEI, X.

    2017-12-01

    To avoid iterative development of core modules in water resource normal regulation and emergency regulation and improve the capability of maintenance and optimization upgrading of regulation models and business logics, a general water resources regulation software framework was developed based on the collection and analysis of common demands for water resources regulation and emergency management. It can provide a customizable, secondary developed and extensible software framework for the three-level platform "MWR-Basin-Province". Meanwhile, this general software system can realize business collaboration and information sharing of water resources regulation schemes among the three-level platforms, so as to improve the decision-making ability of national water resources regulation. There are four main modules involved in the general software system: 1) A complete set of general water resources regulation modules allows secondary developer to custom-develop water resources regulation decision-making systems; 2) A complete set of model base and model computing software released in the form of Cloud services; 3) A complete set of tools to build the concept map and model system of basin water resources regulation, as well as a model management system to calibrate and configure model parameters; 4) A database which satisfies business functions and functional requirements of general water resources regulation software can finally provide technical support for building basin or regional water resources regulation models.

  16. Safety analysis and review system: a Department of Energy safety assurance tool

    International Nuclear Information System (INIS)

    Rosenthal, H.B.

    1981-01-01

    The concept of the Safety Analysis and Review System is not new. It has been used within the Department and its predecessor agencies, Atomic Energy Commission (AEC) and Energy Research and Development Administration (ERDA), for over 20 years. To minimize the risks from nuclear reactor and power plants, the AEC developed a process to support management authorization of each operation through identification and analysis of potential hazards and the measures taken to control them. As the agency evolved from AEC through ERDA to the Department of Energy, its responsibilities were broadened to cover a diversity of technologies, including those associated with the development of fossil, solar, and geothermal energy. Because the safety analysis process had proved effective in a technology of high potential hazard, the Department investigated the applicability of the process to the other technologies. This paper describes the system and discusses how it is implemented within the Department

  17. The electronic security partnership of safety/security and information systems departments.

    Science.gov (United States)

    Yow, J Art

    2012-01-01

    The ever-changing world of security electronics is reviewed in this article. The author focuses on its usage in a hospital setting and the need for safety/security and information systems departments to work together to protect and get full value from IP systems.

  18. 75 FR 28042 - Privacy Act of 1974: System of Records; Department of Homeland Security Transportation Security...

    Science.gov (United States)

    2010-05-19

    ..., VA 20598-6036 or [email protected] . For privacy issues please contact: Mary Ellen Callahan (703-235... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2010-0013] Privacy Act of..., Transportation Security Enforcement Record System, System of Records AGENCY: Privacy Office, DHS. ACTION: Notice...

  19. 78 FR 51747 - Meeting of the Department of Justice's (DOJ's) National Motor Vehicle Title Information System...

    Science.gov (United States)

    2013-08-21

    ... Department of Justice's (DOJ's) National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... announcement of a meeting of DOJ's National Motor Vehicle Title Information System (NMVTIS) Federal Advisory.... FOR FURTHER INFORMATION CONTACT: Todd Brighton, Designated Federal Employee (DFE), Bureau of Justice...

  20. 76 FR 8778 - Meeting of the Department of Justice's (DOJ's) National Motor Vehicle Title Information System...

    Science.gov (United States)

    2011-02-15

    ... Department of Justice's (DOJ's) National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... announcement of a meeting of DOJ's National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... 7th Street, NW., Washington, DC 20531; Phone: (202) 305-1661. FOR FURTHER INFORMATION CONTACT: Alissa...

  1. 75 FR 31815 - Meeting of the Department of Justice's (DOJ's) National Motor Vehicle Title Information System...

    Science.gov (United States)

    2010-06-04

    ... Department of Justice's (DOJ's) National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... announcement of a meeting of DOJ's National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... 7th Street, NW., Washington, DC 20531; Phone: (202) 305-1661. FOR FURTHER INFORMATION CONTACT: Alissa...

  2. 77 FR 10573 - Meeting of the Department of Justice's (DOJ's) National Motor Vehicle Title Information System...

    Science.gov (United States)

    2012-02-22

    ... Department of Justice's (DOJ's) National Motor Vehicle Title Information System (NMVTIS) Federal Advisory... announcement of a meeting of DOJ's National Motor Vehicle Title Information System (NMVTIS) Federal Advisory.... FOR FURTHER INFORMATION CONTACT: Todd Brighton, Designated Federal Employee (DFE), Bureau of Justice...

  3. Nuclear energy system department annual report. April 1, 2000 - March 31, 2001

    International Nuclear Information System (INIS)

    Osugi, Toshitaka; Takase, Kazuyuki; Kunii, Katsuhiko

    2002-03-01

    This report summarizes the research and development activities in the Department of Nuclear Energy System during the fiscal year of 2000 (April 1, 2000 - March 31, 2001). The Department has been organized from April 1998. The main research activity is aimed to build the basis of the development of future nuclear energy systems. The research activities of the Department cover basic nuclear and atomic and molecular data evaluation, conceptual design of a reduced-moderation water reactor, reactor physics experiments and development of the reactor analysis codes, experiment and analysis of thermal-hydrodynamics, energy system analysis and assessment, development of advanced materials for a reactor, lifetime reliability assessment on structural material, development of advanced nuclear fuel, study of nuclear transmutation systems, design of a marine reactor and the research for a nuclear ship system. The maintenance and operation of reactor engineering facilities belonging to the Department are undertaken. The activities of the research committees to which the Department takes a role of secretariat are also summarized in this report. (author)

  4. System certification progress in concept recognition in IAEA regulation

    International Nuclear Information System (INIS)

    Luna, R.E.; Pollog, T.

    1995-01-01

    System Certification is a regulatory concept which is intended to expand the scope of radioactive material transport regulations by allowing alternative means for proving compliance with the requisite standards of safety set out in transport regulations. In practice it may allow more stringent requirements in one aspect of the regulations to be substituted for less stringent application in other areas so long as the safety standard provided by regulation is preserved. The concept is widely perceived as the imposition of operational controls in exchange for relaxation of packaging standards, but that is only one possibility in the spectrum of potential actions under a System Certification provision in IAEA or national regulations

  5. University of California San Francisco automated radiology department system-without picture archival and communication system (PACS)

    Science.gov (United States)

    Quintin, June A.; Simborg, Donald W.

    1982-01-01

    A fully automated and comprehensive Radiology Department system was implemented in the Fall of 1980, which highly integrates the multiple functions of a large Radiology Department in a major medical center. The major components include patient registration, film tracking, management statistics, patient flow control, radiologist reporting, pathology coding and billing. The highly integrated design allows sharing of critical files to reduce redundancy and errors in communication and allows rapid dissemination of information throughout the department. As one node of an integrated distributed hospital system, information from central hospital functions such as patient identification are incorporated into the system and reports and other information are available to other hospital systems. The system is implemented on a Data General Eclipse S/250 using the MIIS operating system. The management of a radiology department has become sufficiently complex that the application of computer techniques to the smooth operation of the department has become almost a necessity. This system provides statistics on room utilization, technologist productivity, and radiologist activity. Room utilization graphs are a valuable aid for staffing and scheduling of technologists, as well as analyzing appropriateness of radiologic equipment in a department. Daily reports summarize by radiology section exams not dictated. File room reports indicate which film borrowers are delinquent in returning films for 24 hours, 48 hours and one week. Letters to the offenders are automatically generated on the high speed line printer. Although all radiology departments have similar needs, customization is likely to be required to meet specific priorities and needs at any individual department. It is important in choosing a system vendor that such flexibility be available. If appropriately designed, a system will provide considerable improvements in efficiency and effectiveness.

  6. Evaluating a voice recognition system: finding the right product for your department.

    Science.gov (United States)

    Freeh, M; Dewey, M; Brigham, L

    2001-06-01

    The Department of Radiology at the University of Utah Health Sciences Center has been in the process of transitioning from the traditional film-based department to a digital imaging department for the past 2 years. The department is now transitioning from the traditional method of dictating reports (dictation by radiologist to transcription to review and signing by radiologist) to a voice recognition system. The transition to digital operations will not be complete until we have the ability to directly interface the dictation process with the image review process. Voice recognition technology has advanced to the level where it can and should be an integral part of the new way of working in radiology and is an integral part of an efficient digital imaging department. The transition to voice recognition requires the task of identifying the product and the company that will best meet a department's needs. This report introduces the methods we used to evaluate the vendors and the products available as we made our purchasing decision. We discuss our evaluation method and provide a checklist that can be used by other departments to assist with their evaluation process. The criteria used in the evaluation process fall into the following major categories: user operations, technical infrastructure, medical dictionary, system interfaces, service support, cost, and company strength. Conclusions drawn from our evaluation process will be detailed, with the intention being to shorten the process for others as they embark on a similar venture. As more and more organizations investigate the many products and services that are now being offered to enhance the operations of a radiology department, it becomes increasingly important that solid methods are used to most effectively evaluate the new products. This report should help others complete the task of evaluating a voice recognition system and may be adaptable to other products as well.

  7. Forest regulation methods and silvicultural systems: what are they?

    Science.gov (United States)

    Ivan L. Sander; Burnell C. Fischer

    1989-01-01

    "Forest regulation methods" and "silvicultural systems" are important forest resource management concepts but there is much confusion about them. They often mean different things to different individuals. Confusion exists in part because "forest regulation methods" and "silvicultural systems" often use the same terminology. Also...

  8. Nuclear Energy System Department annual report. (April 1, 2002 - March 31, 2003)

    International Nuclear Information System (INIS)

    Nakajima, Hajime; Shibata, Keiichi; Kugo, Teruhiko

    2003-09-01

    This report summarizes the research and development activities in the Department of Nuclear Energy System during the fiscal year of 2002 (April 1, 2002 - March 31, 2003). The Department has carried out researches and developments (R and Ds) of innovative nuclear energy system and their related fundamental technologies to ensure the long-term energy supply in Japan. The report deals with the R and Ds of an innovative water reactor, called Reduced-Moderation Water Reactor (RMWR), which has the capability of multiple recycling and breeding of plutonium using light water reactor technologies. In addition, as basic studies and fundamental researches of nuclear energy system in general, described are intensive researches in the fields of reactor physics, thermal-hydraulics, nuclear data, nuclear fuels, and materials. These activities are essential not only for the R and Ds of innovative nuclear energy systems but also for the improvement of safety and reliability of current nuclear energy systems. The maintenance and operation of reactor engineering facilities belonging to the Department support experimental activities. The activities of the research committees to which the Department takes a role of secretariat are also summarized. (author)

  9. Assessing electronic health record systems in emergency departments: Using a decision analytic Bayesian model.

    Science.gov (United States)

    Ben-Assuli, Ofir; Leshno, Moshe

    2016-09-01

    In the last decade, health providers have implemented information systems to improve accuracy in medical diagnosis and decision-making. This article evaluates the impact of an electronic health record on emergency department physicians' diagnosis and admission decisions. A decision analytic approach using a decision tree was constructed to model the admission decision process to assess the added value of medical information retrieved from the electronic health record. Using a Bayesian statistical model, this method was evaluated on two coronary artery disease scenarios. The results show that the cases of coronary artery disease were better diagnosed when the electronic health record was consulted and led to more informed admission decisions. Furthermore, the value of medical information required for a specific admission decision in emergency departments could be quantified. The findings support the notion that physicians and patient healthcare can benefit from implementing electronic health record systems in emergency departments. © The Author(s) 2015.

  10. Limit regulation system for pressurized water nuclear reactors

    International Nuclear Information System (INIS)

    Aleite, W.; Bock, H.W.

    1976-01-01

    Described is a limit regulation system for a pressurized water nuclear reactor in combination with a steam generating system connected to a turbine, the nuclear reactor having control rods as well as an operational regulation system and a protective system, which includes reactor power limiting means operatively associated with the control rods for positioning the same and having response values between operating ranges of the operational regulation system, on the one hand, and response values of the protective system, on the other hand, and a live steam-minimal pressure regulation system cooperating with the reactor power limiting means and operatively connected to a steam inlet valve to the turbine for controlling the same

  11. Effect Mechanism of Penstock on Stability and Regulation Quality of Turbine Regulating System

    Directory of Open Access Journals (Sweden)

    Wencheng Guo

    2014-01-01

    Full Text Available This paper studies the effect mechanism of water inertia and head loss of penstock on stability and regulation quality of turbine regulating system with surge tank or not and proposes the construction method of equivalent model of regulating system. Firstly, the complete linear mathematical model of regulating system is established. Then, the free oscillation equation and time response of the frequency that describe stability and regulation quality, respectively, are obtained. Finally, the effects of penstock are analysed by using stability region and response curves. The results indicate that the stability and regulation quality of system without surge tank are determined by time response of frequency which only depends on water hammer wave in penstock, while, for system with surge tank, the time response of frequency depending on water hammer wave in penstock and water-level fluctuation in surge tank jointly determines the stability and regulation quality. Water inertia of penstock mainly affects the stability and time response of frequency of system without surge tank as well as the stability and head wave of time response of frequency with surge tank. Head loss of penstock mainly affects the stability and tail wave of time response of frequency with surge tank.

  12. A management system of data for department of diagnostic radiology and patients using the personal computer

    International Nuclear Information System (INIS)

    Kim, Jin Hee; Park, Tae Joon; Choi, Tae Haing; Lim, Se Hwan; Joon Yang Noh; Kim, Sung Jin

    1996-01-01

    With the use of personal computers generalized, departmental society leveled computerization is going on in some other departments. So we tried to develop a program having a simple user interface, various retrieval functions and, analytic and statistic process system to effectively help patient care suitable for works concerned with department of diagnostic radiology and works of department. This program deals with such target works as department of diagnostic radiology and some works to need a lot of bookkeeping. It is deviced to operate with Windows (Microsoft, America), and central processing unit(486DX-2), memory unit(8 Mbyte). As a developmental tool, Foxpro 2.6 for windows R (Microsoft, America). This program can be easily accessed even by staffs poor at computer and it can make many books recording various check-ups and operations unnecessary, which were difficult to keep. Besides, it can keep data as a unified form, and so it provides patient care and other works with convenience and helps applying those stored data scientific research. The above result shows that works of department can be effectively controlled by analyzing or printing various check-up and operation done by department of diagnostic radiology

  13. FZKA, Department of Applied Systems Analysis. R + D activities in 1994

    International Nuclear Information System (INIS)

    1995-01-01

    The Department worked in the fields of technology assessment, marterials flow analysis, and socioeconomic environmental research. The characteristic feature of AFAS work is its systems-analytical approach and the interdisciplinary cooperation between scientists, engineers, economists and social scientists. (orig./HP) [de

  14. Nuclear Energy System Department annual report (April 1, 1998 - March 31, 1999)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-01-01

    This report summarizes the research and development activities in the Department of Nuclear Energy System during the fiscal year of 1998 (April 1, 1998 - March 31, 1999). The Department has been organized from April 1998. The main research activity is aimed to build the basis of the development of future nuclear energy system. The research activities of the fiscal year cover basic nuclear and atomic and molecular data evaluation, conceptual design of reduced-moderation water reactor, development of reactor analysis code, reactor physics study on fast neutron system, control and sensing technology development for nuclear reactor, experiment and analysis of thermal-hydrodynamics, development of advanced material for reactor, lifetime reliability assessment on structural material for advanced reactor, development of advanced nuclear fuel, design of marine reactor and the research for nuclear ship system. The maintenance and operation of reactor engineering facilities belonging to the Department are undertaken. The activities of the research committee to which the Department takes a role of secretariat are also summarized in this report. The 98 papers are indexed individually. (J.P.N.)

  15. Acute asthma severity identification of expert system flow in emergency department

    Science.gov (United States)

    Sharif, Nurul Atikah Mohd; Ahmad, Norazura; Ahmad, Nazihah; Desa, Wan Laailatul Hanim Mat

    2017-11-01

    Integration of computerized system in healthcare management help in smoothening the documentation of patient records, highly accesses of knowledge and clinical practices guideline, and advice on decision making. Exploit the advancement of artificial intelligent such as fuzzy logic and rule-based reasoning may improve the management of emergency department in terms of uncertainty condition and medical practices adherence towards clinical guideline. This paper presenting details of the emergency department flow for acute asthma severity identification with the embedding of acute asthma severity identification expert system (AASIES). Currently, AASIES is still in preliminary stage of system validation. However, the implementation of AASIES in asthma bay management is hope can reduce the usage of paper for manual documentation and be a pioneer for the development of a more complex decision support system to smoothen the ED management and more systematic.

  16. Drug Rash with Eosinophilia and Systemic Symptoms: Two Emergency Department Cases

    OpenAIRE

    Tsyrulnik, Alina; Landman, Adam B.

    2011-01-01

    Drug rash with eosinophilia and systemic symptoms (DRESS) is a rare, severe adverse drug event that appears with a generalized rash, fevers, and dysfunction of 1 or more organ systems. We describe 2 patients (1 adult and 1 pediatric) seen in the emergency department with DRESS, and review the clinical presentations, potential complications, and management of DRESS. Although rare, it can be associated with significant morbidity, including liver failure and death, and should be considered in th...

  17. International Health Regulations (2005 and the U.S. Department of Defense: building core capacities on a foundation of partnership and trust

    Directory of Open Access Journals (Sweden)

    Blazes David L

    2010-12-01

    Full Text Available Abstract A cornerstone of effective global health surveillance programs is the ability to build systems that identify, track and respond to public health threats in a timely manner. These functions are often difficult and require international cooperation given the rapidity with which diseases cross national borders and spread throughout the global community as a result of travel and migration by both humans and animals. As part of the U.S. Armed Forces Health Surveillance Center (AFHSC, the Department of Defense’s (DoD Globa Emerging Infections Surveillance and Response System (AFHSC-GEIS has developed a global network of surveillance sites over the past decade that engages in a wide spectrum of support activities in collaboration with host country partners. Many of these activities are in direct support of International Health Regulations (IHR[2005]. The network also supports host country military forces around the world, which are equally affected by these threats and are often in a unique position to respond in areas of conflict or during complex emergencies. With IHR(2005 as the guiding framework for action, the AFHSC-GEIS network of international partners and overseas research laboratories continues to develop into a far-reaching system for identifying, analyzing and responding to emerging disease threats.

  18. International Health Regulations (2005) and the U.S. Department of Defense: building core capacities on a foundation of partnership and trust.

    Science.gov (United States)

    Johns, Matthew C; Blazes, David L

    2010-12-03

    A cornerstone of effective global health surveillance programs is the ability to build systems that identify, track and respond to public health threats in a timely manner. These functions are often difficult and require international cooperation given the rapidity with which diseases cross national borders and spread throughout the global community as a result of travel and migration by both humans and animals. As part of the U.S. Armed Forces Health Surveillance Center (AFHSC), the Department of Defense's (DoD) Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) has developed a global network of surveillance sites over the past decade that engages in a wide spectrum of support activities in collaboration with host country partners. Many of these activities are in direct support of International Health Regulations (IHR[2005]). The network also supports host country military forces around the world, which are equally affected by these threats and are often in a unique position to respond in areas of conflict or during complex emergencies. With IHR(2005) as the guiding framework for action, the AFHSC-GEIS network of international partners and overseas research laboratories continues to develop into a far-reaching system for identifying, analyzing and responding to emerging disease threats.

  19. Digital imaging and electronic patient records in pathology using an integrated department information system with PACS.

    Science.gov (United States)

    Kalinski, Thomas; Hofmann, Harald; Franke, Dagmar-Sybilla; Roessner, Albert

    2002-01-01

    Picture archiving and communication systems have been widely used in radiology thus far. Owing to the progress made in digital photo technology, their use in medicine opens up further opportunities. In the field of pathology, digital imaging offers new possiblities for the documentation of macroscopic and microscopic findings. Digital imaging has the advantage that the data is permanently and readily available, independent of conventional archives. In the past, PACS was a separate entity. Meanwhile, however, PACS has been integrated in DIS, the department information system, which was also run separately in former times. The combination of these two systems makes the administration of patient data, findings and images easier. Moreover, thanks to the introduction of special communication standards, a data exchange between different department information systems and hospital information systems (HIS) is possible. This provides the basis for a communication platform in medicine, constituting an electronic patient record (EPR) that permits an interdisciplinary treatment of patients by providing data of findings and images from clinics treating the same patient. As the pathologic diagnosis represents a central and often therapy-determining component, it is of utmost importance to add pathologic diagnoses to the EPR. Furthermore, the pathologist's work is considerably facilitated when he is able to retrieve additional data from the patient file. In this article, we describe our experience gained with the combined PACS and DIS systems recently installed at the Department of Pathology, University of Magdeburg. Moreover, we evaluate the current situation and future prospects for PACS in pathology.

  20. TRANSCOM: The US Department of Energy (DOE) system for tracking shipments

    International Nuclear Information System (INIS)

    Boes, K.S.; Joy, D.S.; Pope, R.B.; Thomas, T.M.; Lester, P.B.

    1994-01-01

    The US Department of energy (DOE) Transportation Management Division (TMD) has developed a system which allows communications with and near real-time tracking of high-visibility shipments of hazardous materials. This system, which is known as TRANSCOM (Transportation Tracking and Communications System), is currently in operation. This paper summarizes the current status of TRANSCOM, its history, the experience associated with its use, and the future plans for its growth and enhancement. during the first half of fiscal year (FY) 1994, 38 shipments were tracked by the TRANSCOM system. These shipments included two Mark-42 spent fuel shipments, one BUSS cask shipment, and one waterway shipment (the Seawolf shipment)

  1. A System Dynamics Approach to Modeling the Sensitivity of Inappropriate Emergency Department Utilization

    Science.gov (United States)

    Behr, Joshua G.; Diaz, Rafael

    Non-urgent Emergency Department utilization has been attributed with increasing congestion in the flow and treatment of patients and, by extension, conditions the quality of care and profitability of the Emergency Department. Interventions designed to divert populations to more appropriate care may be cautiously received by operations managers due to uncertainty about the impact an adopted intervention may have on the two values of congestion and profitability. System Dynamics (SD) modeling and simulation may be used to measure the sensitivity of these two, often-competing, values of congestion and profitability and, thus, provide an additional layer of information designed to inform strategic decision making.

  2. Outpatient and Ambulatory Surgery Consumer Assessment of Healthcare Providers and Systems (OAS CAHPS) survey for hospital outpatient departments - Facility

    Data.gov (United States)

    U.S. Department of Health & Human Services — A list of hospital outpatient department ratings for the Outpatient and Ambulatory Surgery Consumer Assessment of Healthcare Providers and Systems (OAS CAHPS)...

  3. William D. Ford Federal Direct Loan Program. Final Regulations. Federal Register, Department of Education, 34 CFR Part 685

    Science.gov (United States)

    National Archives and Records Administration, 2014

    2014-01-01

    The purpose of this regulatory action is to amend the regulations governing the William D. Ford Federal Direct Loan (Direct Loan) Program (§ 685.200 of title 34 of the Code of Federal Regulations (CFR)). These regulations strengthen and improve administration of the Federal Direct PLUS Loan Program authorized under title IV of the Higher Education…

  4. The simple analytics of systemic liquidity risk regulation

    NARCIS (Netherlands)

    Perotti, E.; Suarez, J.

    2011-01-01

    How to regulate systemic risk? This column presents a new CEPR discussion paper assessing the performance of Pigouvian taxes and quantity-based regulations in containing the social costs of high-risk banking. It finds that, depending on how banks differ, the socially efficient solution may be

  5. Troubleshooting the General Electric Company Neutron Devices Department's deionized water system

    International Nuclear Information System (INIS)

    Gillespie, T.J.

    1983-01-01

    In May 1982, the General Electric Neutron Devices Department's deionized (DI) water system was found to be highly contaminated with fresh water roundworms which caused severe filter plugging problems. Subsequently, a DI water improvement program was developed by GEND's Process Technology, Contamination Control, and Facilities Engineering groups. This program included removal of dead ends in the distribution system, a consultant's review, significant modification of the DI water system, modification of system operation, design of a quality plan, and changes in the types of water analysis. During implementation of the improvement program, a severe bacteria contamination problem occurred due to a contractor accident. Correction of this problem required sterilization of portions of the DI water system and significant modification of the water filtration system. The system modifications and sterilization procedures have significantly reduced bacteria and total solids contamination while resistivity is generally increasing

  6. [Perceived quality in hospitals of the Andalusia Healthcare System. The case of neurosurgery departments].

    Science.gov (United States)

    Cordero Tous, N; Horcajadas Almansa, Á; Bermúdez González, G J; Tous Zamora, D

    2014-01-01

    To analyse the characteristics of the perceived quality in hospitals of the Andalusia healthcare system and compare this with that in Andalusian Neurosurgery departments. Randomised surveys, adjusted for working age, were performed in Andalusia using a telephone questionnaire based on the SERVQUAL model with the appropriate modification, with the subsequent selection of a subgroup associated with neurosurgery. Perceived quality was classified as; technical, functional and infrastructure quality. The overall satisfaction was 76.3%. Frequency analysis found that variables related to the technical quality (good doctors, successful operations, trained staff, etc.) obtained more favourable outcomes. Those related to time (wait, consulting, organizing schedules) obtained worse outcomes. The care of families variables obtained poor results. There was no difference between the overall Andalusian healthcare system and neurosurgery departments. In the mean analysis, women and older people gave more favourable responses, especially for variables related to infrastructure quality. In the "cluster" analysis, there were more favourable responses by elderly people, with no differences in gender (P<.009). There is no difference in perceived quality between the Andalusian healthcare system overall and neurosurgery departments. The perceived quality of the Andalusian healthcare system is higher in the elderly people. The analysis of perceived quality is useful for promoting projects to improve clinical management. Copyright © 2014 SECA. Published by Elsevier Espana. All rights reserved.

  7. Patient dose monitoring systems: A new way of managing patient dose and quality in the radiology department.

    Science.gov (United States)

    Fitousi, N

    2017-12-01

    Due to the upcoming European Directive (2013/59/EURATOM) and the increased focus on patient safety in international guidelines and regulations, Patient Dose Monitoring Systems, also called Dose Management Systems (DMS), are introduced in medical imaging departments. This article focusses on the requirements for a DMS, its benefits and the necessary implementation steps. The implementation of a DMS can be perceived as a lengthy, yet worthy, procedure: users have to select the appropriate system for their applications, prepare data collection, validate, perform configuration, and start using the results in quality improvement projects. A state of the art DMS improves the quality of service, ensures patient safety and optimizes the efficiency of the department. The gain is multifaceted: the initial goal is compliance monitoring against diagnostic reference levels. At a higher level, the user gets an overview of the performance of the devices or centers that are under his supervision. Error identification, generation of alerts and workflow analysis are additional benefits. It can also enable a more patient-centric approach with personalized dosimetry. Skin dose, size-specific dose estimates and organ doses can be calculated and evaluated per patient. A DMS is a powerful tool and essential for improved quality and patient care in a radiology department. It can be configured to the needs of medical physicists, radiologists, technologists, even for the management of the hospital. Collaboration between all health professionals and stakeholders, input-output validation and communication of findings are key points in the process of a DMS implementation. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  8. Estimation of regulated term of technical systems further operation

    International Nuclear Information System (INIS)

    Strel'nikov, V.P.

    2008-01-01

    The technique of estimating the regulated term of technical systems further operation on the basis of data on failures during operation and use of probabilistic-physical model of failures (DN-distribution) is proposed

  9. Adoption of medication alert systems in hospital outpatient departments in Taiwan.

    Science.gov (United States)

    Kuo, Yu-Chun; Cheng, Shou-Hsia

    2017-06-01

    The adoption of medication alert systems in the health care sector varies among regions. In Taiwan, the health authority introduced policies in 2005 to encourage the adoption of medication alert systems in hospitals. This study aimed to understand the adoption of medication alert systems in the outpatient departments of hospitals in Taiwan using a nationwide survey. A questionnaire was developed and mailed to 380 accredited general hospitals in Taiwan in 2013. The information collected from the questionnaire concerning the outpatient department included (1) the time of adoption of a medication alert system; (2) the operation of individual alert functions: availability, management, and stability; and (3) hospital characteristics: accreditation level, teaching status, ownership, and number of beds. A total of 216 hospitals completed and returned the questionnaire, corresponding to a response rate of 56.8%. The adoption rate of medication alert systems in hospital outpatient departments increased from less than 10% in 1997-95.83% in 2012. Approximately two-thirds of the hospitals developed and maintained the alert systems independently or collaboratively with vendors. Teaching and large hospitals tended to develop more advanced alert functions such as drug-drug interaction functions. Improving the safety and quality of pharmaceutical services and meeting the policy requirements are reasons for hospitals to establish medication alert systems. The adoption rate of medication alert systems reached 95% in accredited general hospitals in Taiwan. Government policy and available health information professionals and vendors may somewhat contribute to the high adoption rate. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. 34 CFR 79.3 - What programs and activities of the Department are subject to these regulations?

    Science.gov (United States)

    2010-07-01

    ... Metropolitan Development Act. (b) If a program or activity of the Department that provides Federal financial.... (5) Direct payments to individuals. (6) Financial transfers for which the Department has no funding... the Education Consolidation and Improvement Act of 1981). (7) Research and development national in...

  11. CREBH Regulates Systemic Glucose and Lipid Metabolism

    Directory of Open Access Journals (Sweden)

    Yoshimi Nakagawa

    2018-05-01

    Full Text Available The cyclic adenosine monophosphate (cAMP-responsive element-binding protein H (CREBH, encoded by CREB3L3 is a membrane-bound transcriptional factor that primarily localizes in the liver and small intestine. CREBH governs triglyceride metabolism in the liver, which mediates the changes in gene expression governing fatty acid oxidation, ketogenesis, and apolipoproteins related to lipoprotein lipase (LPL activation. CREBH in the small intestine reduces cholesterol transporter gene Npc1l1 and suppresses cholesterol absorption from diet. A deficiency of CREBH in mice leads to severe hypertriglyceridemia, fatty liver, and atherosclerosis. CREBH, in synergy with peroxisome proliferator-activated receptor α (PPARα, has a crucial role in upregulating Fgf21 expression, which is implicated in metabolic homeostasis including glucose and lipid metabolism. CREBH binds to and functions as a co-activator for both PPARα and liver X receptor alpha (LXRα in regulating gene expression of lipid metabolism. Therefore, CREBH has a crucial role in glucose and lipid metabolism in the liver and small intestine.

  12. Implementation of decision support system in the central AQUATOOL Department of Valle del Cauca

    International Nuclear Information System (INIS)

    Gutierrez Enriquez, Maria Mercedes; Aristizabal Rodriguez, Hector Fabio

    2007-01-01

    The decision support system AQUATOOL, created by the Polytechnic University of Valencia (Spain), represents an alternative for water resources management for it makes it possible to evaluate planning scenarios for the use of both surface and groundwater. For the evaluation of this tool, the application zone chosen was the Central Region of the Valle del Cauca State in Colombia. With the mathematical model AQUATOOL technical scenarios were formulated focused on the efficient satisfaction of demands in the zone, based on a supply - demand scheme, in which only real demand was included in the regulations for the use of every stream. As far as surface waters are concerned, a special feature of the State concerns its torrential flow rivers, not regulated. Though there are feasibility studies for regulation dams in the zone. Based on this initial scheme several alternatives were presented: aquifer swell and study of dams projected as complementary supply resources, aiming to greater satisfaction of present and future demands.

  13. Information systems for the materials management department: stand-alone and enterprise resource planning systems.

    Science.gov (United States)

    2005-03-01

    Materials management information systems (MMISs) incorporate information tools that hospitals can use to automate certain business processes, increase staff compliance with these processes, and identify opportunities for cost savings. Recently, there has been a push by hospital administration to purchase enterprise resource planning (ERP) systems, information systems that promise to integrate many more facets of healthcare business. We offer this article to help materials managers, administrators, and others involved with information system selection understand the changes that have taken place in materials management information systems, decide whether they need a new system and, if so, whether a stand-alone MMIS or an ERP system will be the best choice.

  14. Establishing an emergency department syndromic surveillance system to support the London 2012 Olympic and Paralympic Games.

    Science.gov (United States)

    Elliot, Alex J; Hughes, Helen E; Hughes, Thomas C; Locker, Thomas E; Shannon, Tony; Heyworth, John; Wapling, Andy; Catchpole, Mike; Ibbotson, Sue; McCloskey, Brian; Smith, Gillian E

    2012-12-01

    The London 2012 Olympic and Paralympic Games is a mass gathering event that will present a major public health challenge. The Health Protection Agency, in collaboration with the College of Emergency Medicine, has established the Emergency Department Sentinel Syndromic Surveillance System (EDSSS) to support the public health surveillance requirements of the Games. This feasibility study assesses the usefulness of EDSSS in monitoring indicators of disease in the community. Daily counts of anonymised attendance data from six emergency departments across England were analysed by patient demographics (age, gender, partial postcode), triage coding and diagnosis codes. Generic and specific syndromic indicators were developed using aggregations of diagnosis codes recorded during each attendance. Over 339,000 attendances were recorded (26 July 2010 to 25 July 2011). The highest attendances recorded on weekdays between 10:00 and 11:00 and on weekends between 12:00 and 13:00. The mean daily attendance per emergency department was 257 (range 38-435). Syndromic indicators were developed including: respiratory, gastrointestinal, cardiac, acute respiratory infection, gastroenteritis and myocardial ischaemia. Respiratory and acute respiratory infection indicators peaked during December 2010, concomitant with national influenza activity, as monitored through other influenza surveillance systems. The EDSSS has been established to provide an enhanced surveillance system for the London 2012 Olympics. Further validation of the data will be required; however, the results from this initial descriptive study demonstrate the potential for identifying unusual and/or severe outbreaks of infectious disease, or other incidents with public health impact, within the community.

  15. 28 CFR 16.132 - Exemption of Department of Justice System-Personnel Investigation and Security Clearance Records...

    Science.gov (United States)

    2010-07-01

    ... System—Personnel Investigation and Security Clearance Records for the Department of Justice (DOJ), DOJ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of Department of Justice System-Personnel Investigation and Security Clearance Records for the Department of Justice (DOJ), DOJ-006. 16.132...

  16. Numerical Simulation of Tubular Pumping Systems with Different Regulation Methods

    Science.gov (United States)

    Zhu, Honggeng; Zhang, Rentian; Deng, Dongsheng; Feng, Xusong; Yao, Linbi

    2010-06-01

    Since the flow in tubular pumping systems is basically along axial direction and passes symmetrically through the impeller, most satisfying the basic hypotheses in the design of impeller and having higher pumping system efficiency in comparison with vertical pumping system, they are being widely applied to low-head pumping engineering. In a pumping station, the fluctuation of water levels in the sump and discharge pool is most common and at most time the pumping system runs under off-design conditions. Hence, the operation of pump has to be flexibly regulated to meet the needs of flow rates, and the selection of regulation method is as important as that of pump to reduce operation cost and achieve economic operation. In this paper, the three dimensional time-averaged Navier-Stokes equations are closed by RNG κ-ɛ turbulent model, and two tubular pumping systems with different regulation methods, equipped with the same pump model but with different designed system structures, are numerically simulated respectively to predict the pumping system performances and analyze the influence of regulation device and help designers make final decision in the selection of design schemes. The computed results indicate that the pumping system with blade-adjusting device needs longer suction box, and the increased hydraulic loss will lower the pumping system efficiency in the order of 1.5%. The pumping system with permanent magnet motor, by means of variable speed regulation, obtains higher system efficiency partly for shorter suction box and partly for different structure design. Nowadays, the varied speed regulation is realized by varied frequency device, the energy consumption of which is about 3˜4% of output power of the motor. Hence, when the efficiency of variable frequency device is considered, the total pumping system efficiency will probably be lower.

  17. Quality management system of a university cardiac surgery department according to DIN EN ISO 9001 : 2000.

    Science.gov (United States)

    Beholz, S; Koch, C; Konertz, W

    2003-06-01

    A quality management system (QMS) will improve quality in health care units. This report describes the introduction of a QMS according to ISO 9001:2000 in a university cardiovascular surgery department. First, a thorough analysis of all processes of patient treatment and clinical research was obtained. Multiple interfaces were defined to different departments as well as to administration units. We evaluated and optimized all necessary resources, evaluating customer satisfaction using patients' and referring physicians' surveys. We started quality rounds including surgeons, nurses and technicians. Based on this preparation, we redefined and explained all processes including their responsibilities and necessary resources in the quality manual. After a process of 18 months, an independent, accredited organization recommended that our QMS be given certification according to ISO 9001:2000. Certification of a university cardiovascular surgery department according to ISO 9001:2000 is possible, and may represent the first step towards total quality management (TQM). In complex health care units, certification of separate departments may help generate a consciousness of quality on the way to TQM.

  18. US Department of Energy Laboratory Accredition Program (DOELAP) for personnel dosimetry systems

    Energy Technology Data Exchange (ETDEWEB)

    Cummings, F.M.; Carlson, R.D.; Loesch, R.M.

    1993-12-31

    Accreditation of personnel dosimetry systems is required for laboratories that conduct personnel dosimetry for the U.S. Department of Energy (DOE). Accreditation is a two-step process which requires the participant to pass a proficiency test and an onsite assessment. The DOE Laboratory Accreditation Program (DOELAP) is a measurement quality assurance program for DOE laboratories. Currently, the DOELAP addresses only dosimetry systems used to assess the whole body dose to personnel. A pilot extremity DOELAP has been completed and routine testing is expected to begin in January 1994. It is expected that participation in the extremity program will be a regulatory requirement by January 1996.

  19. Seasonal ARMA-based SPC charts for anomaly detection: Application to emergency department systems

    KAUST Repository

    Kadri, Farid

    2015-10-22

    Monitoring complex production systems is primordial to ensure management, reliability and safety as well as maintaining the desired product quality. Early detection of emergent abnormal behaviour in monitored systems allows pre-emptive action to prevent more serious consequences, to improve system operations and to reduce manufacturing and/or service costs. This study reports the design of a new methodology for the detection of abnormal situations based on the integration of time-series analysis models and statistical process control (SPC) tools for the joint development of a monitoring system to help supervising of the behaviour of emergency department services (EDs). The monitoring system developed is able to provide early alerts in the event of abnormal situations. The seasonal autoregressive moving average (SARMA)-based exponentially weighted moving average (EWMA) anomaly detection scheme proposed was successfully applied to the practical data collected from the database of the paediatric emergency department (PED) at Lille regional hospital centre, France. The method developed utilizes SARMA as a modelling framework and EWMA for anomaly detection. The EWMA control chart is applied to the uncorrelated residuals obtained from the SARMA model. The detection results of the EWMA chart are compared with two other commonly applied residual-based tests: a Shewhart individuals chart and a Cumulative Sum (CUSUM) control chart.

  20. Seasonal ARMA-based SPC charts for anomaly detection: Application to emergency department systems

    KAUST Repository

    Kadri, Farid; Harrou, Fouzi; Chaabane, Sondè s; Sun, Ying; Tahon, Christian

    2015-01-01

    Monitoring complex production systems is primordial to ensure management, reliability and safety as well as maintaining the desired product quality. Early detection of emergent abnormal behaviour in monitored systems allows pre-emptive action to prevent more serious consequences, to improve system operations and to reduce manufacturing and/or service costs. This study reports the design of a new methodology for the detection of abnormal situations based on the integration of time-series analysis models and statistical process control (SPC) tools for the joint development of a monitoring system to help supervising of the behaviour of emergency department services (EDs). The monitoring system developed is able to provide early alerts in the event of abnormal situations. The seasonal autoregressive moving average (SARMA)-based exponentially weighted moving average (EWMA) anomaly detection scheme proposed was successfully applied to the practical data collected from the database of the paediatric emergency department (PED) at Lille regional hospital centre, France. The method developed utilizes SARMA as a modelling framework and EWMA for anomaly detection. The EWMA control chart is applied to the uncorrelated residuals obtained from the SARMA model. The detection results of the EWMA chart are compared with two other commonly applied residual-based tests: a Shewhart individuals chart and a Cumulative Sum (CUSUM) control chart.

  1. Autonomic nervous system activity as risk predictor in the medical emergency department: a prospective cohort study.

    Science.gov (United States)

    Eick, Christian; Rizas, Konstantinos D; Meyer-Zürn, Christine S; Groga-Bada, Patrick; Hamm, Wolfgang; Kreth, Florian; Overkamp, Dietrich; Weyrich, Peter; Gawaz, Meinrad; Bauer, Axel

    2015-05-01

    To evaluate heart rate deceleration capacity, an electrocardiogram-based marker of autonomic nervous system activity, as risk predictor in a medical emergency department and to test its incremental predictive value to the modified early warning score. Prospective cohort study. Medical emergency department of a large university hospital. Five thousand seven hundred thirty consecutive patients of either sex in sinus rhythm, who were admitted to the medical emergency department of the University of Tübingen, Germany, between November 2010 and March 2012. None. Deceleration capacity of heart rate was calculated within the first minutes after emergency department admission. The modified early warning score was assessed from respiratory rate, heart rate, systolic blood pressure, body temperature, and level of consciousness as previously described. Primary endpoint was intrahospital mortality; secondary endpoints included transfer to the ICU as well as 30-day and 180-day mortality. One hundred forty-two patients (2.5%) reached the primary endpoint. Deceleration capacity was highly significantly lower in nonsurvivors than survivors (2.9 ± 2.1 ms vs 5.6 ± 2.9 ms; p model yielded an area under the receiver-operator characteristic curve of 0.706 (0.667-0.750). Implementing deceleration capacity into the modified early warning score model led to a highly significant increase of the area under the receiver-operator characteristic curve to 0.804 (0.770-0.835; p capacity was also a highly significant predictor of 30-day and 180-day mortality as well as transfer to the ICU. Deceleration capacity is a strong and independent predictor of short-term mortality among patients admitted to a medical emergency department.

  2. Automatic sprinkler system performance and reliability in United States Department of Energy Facilities, 1952 to 1980

    International Nuclear Information System (INIS)

    1982-06-01

    The automatic sprinkler system experiences of the United States Department of Energy and its predecessor agencies are analyzed. Based on accident and incident files in the Office of Operational Safety and on supplementary responses, 587 incidents including over 100 fires are analyzed. Tables and figures, with supplementary narratives discuss fire experience by various categories such as number of heads operating, type of system, dollar losses, failures, extinguished vs. controlled, and types of sprinkler heads. Use is made of extreme value projections and frequency-severity plots to compare past experience and predict future experience. Non-fire incidents are analyzed in a similar manner by cause, system types and failure types. Discussion of no-loss incidents and non-fire protection water systems is included. The author's conclusions and recommendations and appendices listing survey methodology, major incidents, and a bibliography are included

  3. Case report: treatment of subdural hematoma in the emergency department utilizing the subdural evacuating port system.

    Science.gov (United States)

    Asfora, Wilson T; Klapper, Hendrik B

    2013-08-01

    Patients with acute or chronic subdural hematomas may present with rapidly deteriorating neurological function and are at risk for irreversible brainstem injury. In such cases, rapid surgical intervention is required to evacuate the hematoma and reverse critically elevated intracranial pressure. A variety of surgical drainage methods are in existence, none of which are clearly superior to the others. This report presents the case of a 74-year-old woman who suffered an acute-on-chronic subdural hematoma which was evacuated in the emergency department utilizing the subdural evacuating port system (SEPS). The SEPS provides for a minimally invasive technique to drain subdural hematomas and is advantageous in that it can be performed at the bedside. The SEPS is relatively simple to use and may be especially useful to emergency department staff in outlying areas where there is a shortage of neurosurgical coverage.

  4. Practical implementation of a quality management system in a radiological department

    International Nuclear Information System (INIS)

    Huber, S.; Zech, C.J.

    2011-01-01

    This article describes the architecture of a project aiming to implement a DIN EN ISO 9001 quality management system in a radiological department. It is intended to be a practical guide to demonstrate each step of the project leading to certification of the system. In a planning phase resources for the implementation of the project have to be identified and a quality management (QM) group as core team has to be formed. In the first project phase all available documents have to be checked and compiled in the QM manual. Moreover all relevant processes of the department have to be described in so-called process descriptions. In a second step responsibilities for the project are identified. Customer and employee surveys have to be carried out and a nonconformity management system has to be implemented. In this phase internal audits are also needed to check the new QM system, which is finally tested in the external certification audit with reference to its conformity with the standards. (orig.) [de

  5. [Practical implementation of a quality management system in a radiological department].

    Science.gov (United States)

    Huber, S; Zech, C J

    2011-10-01

    This article describes the architecture of a project aiming to implement a DIN EN ISO 9001 quality management system in a radiological department. It is intended to be a practical guide to demonstrate each step of the project leading to certification of the system. In a planning phase resources for the implementation of the project have to be identified and a quality management (QM) group as core team has to be formed. In the first project phase all available documents have to be checked and compiled in the QM manual. Moreover all relevant processes of the department have to be described in so-called process descriptions. In a second step responsibilities for the project are identified. Customer and employee surveys have to be carried out and a nonconformity management system has to be implemented. In this phase internal audits are also needed to check the new QM system, which is finally tested in the external certification audit with reference to its conformity with the standards.

  6. An integrative review of information systems and terminologies used in local health departments.

    Science.gov (United States)

    Olsen, Jeanette; Baisch, Mary Jo

    2014-02-01

    The purpose of this integrative review based on the published literature was to identify information systems currently being used by local health departments and to determine the extent to which standard terminology was used to communicate data, interventions, and outcomes to improve public health informatics at the local health department (LHD) level and better inform research, policy, and programs. Whittemore and Knafl's integrative review methodology was used. Data were obtained through key word searches of three publication databases and reference lists of retrieved articles and consulting with experts to identify landmark works. The final sample included 45 articles analyzed and synthesized using the matrix method. The results indicated a wide array of information systems were used by LHDs and supported diverse functions aligned with five categories: administration; surveillance; health records; registries; and consumer resources. Detail regarding specific programs being used, location or extent of use, or effectiveness was lacking. The synthesis indicated evidence of growing interest in health information exchange groups, yet few studies described use of data standards or standard terminology in LHDs. Research to address these gaps is needed to provide current, meaningful data that inform public health informatics research, policy, and initiatives at and across the LHD level. Coordination at a state or national level is recommended to collect information efficiently about LHD information systems that will inform improvements while minimizing duplication of efforts and financial burden. Until this happens, efforts to strengthen LHD information systems and policies may be significantly challenged.

  7. Development of a safety and regulation systems simulation program II

    International Nuclear Information System (INIS)

    1985-05-01

    This report describes the development of a safety and regulation systems simulation program under contract to the Atomic Energy Control Board of Canada. A systems logic interaction simulation (SLISIM) program was developed for the AECB's HP-1000 computer which operates in the interactive simulation (INSIM) program environment. The SLISIM program simulates the spatial neutron dynamics, the regulation of the reactor power and in this version the CANDU-PHW 600 MW(e) computerized shutdown systems' trip parameters. The modular concept and interactive capability of the INSIM environment provides the user with considerable flexibility of the setup and control of the simulation

  8. Profile-IQ: Web-based data query system for local health department infrastructure and activities.

    Science.gov (United States)

    Shah, Gulzar H; Leep, Carolyn J; Alexander, Dayna

    2014-01-01

    To demonstrate the use of National Association of County & City Health Officials' Profile-IQ, a Web-based data query system, and how policy makers, researchers, the general public, and public health professionals can use the system to generate descriptive statistics on local health departments. This article is a descriptive account of an important health informatics tool based on information from the project charter for Profile-IQ and the authors' experience and knowledge in design and use of this query system. Profile-IQ is a Web-based data query system that is based on open-source software: MySQL 5.5, Google Web Toolkit 2.2.0, Apache Commons Math library, Google Chart API, and Tomcat 6.0 Web server deployed on an Amazon EC2 server. It supports dynamic queries of National Profile of Local Health Departments data on local health department finances, workforce, and activities. Profile-IQ's customizable queries provide a variety of statistics not available in published reports and support the growing information needs of users who do not wish to work directly with data files for lack of staff skills or time, or to avoid a data use agreement. Profile-IQ also meets the growing demand of public health practitioners and policy makers for data to support quality improvement, community health assessment, and other processes associated with voluntary public health accreditation. It represents a step forward in the recent health informatics movement of data liberation and use of open source information technology solutions to promote public health.

  9. Incremental passivity and output regulation for switched nonlinear systems

    Science.gov (United States)

    Pang, Hongbo; Zhao, Jun

    2017-10-01

    This paper studies incremental passivity and global output regulation for switched nonlinear systems, whose subsystems are not required to be incrementally passive. A concept of incremental passivity for switched systems is put forward. First, a switched system is rendered incrementally passive by the design of a state-dependent switching law. Second, the feedback incremental passification is achieved by the design of a state-dependent switching law and a set of state feedback controllers. Finally, we show that once the incremental passivity for switched nonlinear systems is assured, the output regulation problem is solved by the design of global nonlinear regulator controllers comprising two components: the steady-state control and the linear output feedback stabilising controllers, even though the problem for none of subsystems is solvable. Two examples are presented to illustrate the effectiveness of the proposed approach.

  10. Is it possible to improve regulation system of PWR

    International Nuclear Information System (INIS)

    Bonnemay, A.; Martinez, J.M.

    1983-03-01

    This paper deals with two problems: first of all, it presents the critical analysis of usually implemented general regulation systems, on PWR plants, and derives from it same possibilities to improve the transient behavior of reactor, the second part is a proposition from an automatic control system for spatial distribution of flux

  11. Department of Defense Financial Management Regulation. Volume 3. Budget Execution-Availability and Use of Budgetary Resources

    National Research Council Canada - National Science Library

    1996-01-01

    .... In addition, it directs statutory and regulatory financial reporting requirements. Volume 3 of the "DoD Financial Management Regulation" establishes procedures for DoD Components to use in budget execution...

  12. Abnormal Default System Functioning in Depression: Implications for Emotion Regulation.

    Science.gov (United States)

    Messina, Irene; Bianco, Francesca; Cusinato, Maria; Calvo, Vincenzo; Sambin, Marco

    2016-01-01

    Depression is widely seen as the result of difficulties in regulating emotions. Based on neuroimaging studies on voluntary emotion regulation, neurobiological models have focused on the concept of cognitive control, considering emotion regulation as a shift toward involving controlled processes associated with activation of the prefrontal and parietal executive areas, instead of responding automatically to emotional stimuli. According to such models, the weaker executive area activation observed in depressed patients is attributable to a lack of cognitive control over negative emotions. Going beyond the concept of cognitive control, psychodynamic models describe the development of individuals' capacity to regulate their emotional states in mother-infant interactions during childhood, through the construction of the representation of the self, others, and relationships. In this mini-review, we link these psychodynamic models with recent findings regarding the abnormal functioning of the default system in depression. Consistently with psychodynamic models, psychological functions associated with the default system include self-related processing, semantic processes, and implicit forms of emotion regulation. The abnormal activation of the default system observed in depression may explain the dysfunctional aspects of emotion regulation typical of the condition, such as an exaggerated negative self-focus and rumination on self-esteem issues. We also discuss the clinical implications of these findings with reference to the therapeutic relationship as a key tool for revisiting impaired or distorted representations of the self and relational objects.

  13. Nurses’ Evaluation of a New Formalized Triage System in the Emergency Department

    DEFF Research Database (Denmark)

    Brehm Johansen, Mette; Forberg, Jakob Lundager

    2011-01-01

    Introduction: Formalized triage in the emergency department (ED) is not widely used in Denmark; this study explores the effects of introducing a five-level process triage system in a Danish ED. Material and methods: Semi-structured qualitative interviews were conducted with 15 emergency nurses....... The interviews were preceded by observations of the work of the ED nurses in which focus was on the triage process. Results: Formalized triage was experienced to improve the overview of patients and resources at the ED, and the nurses described that they felt more assured when prioritizing between patients....... Communication and coordination were also improved by the triage system. But more time spent on documentation and re-evaluation may cause the nurses to feel professionally inadequate if adequate resources are not provided. Furthermore, the triage system has reduced the focus on the humanistic and psychosocial...

  14. Systems engineering approach to U.S. Department of Energy's commercial nuclear waste transportation program

    International Nuclear Information System (INIS)

    Pardue, W.M.

    1987-01-01

    The U.S Department of Energy (DOE) has been given the responsibility of developing a program to transport commercially produced spent nuclear fuel and high-level radioactive wastes to disposal sites or storage facilities safely and cost-effectively. To accomplish this task it is desirable to plan, perform, and document all technical activities based on systems engineering principles. This paper presents an overview of the systems engineering approach being developed by Battelle for consideration by DOE, specifically the early identification of the required technical activities and approaches to technical management and decision making. The program should support the development of an integrated, well-documented transportation system acceptable to regulatory agencies and the public

  15. The suitability of ISO 9001 as a quality system for a medical illustration department.

    Science.gov (United States)

    Fleming, C M; Armes, F M

    2001-12-01

    The Medical illustration Department within Bradford Hospitals NHS Trust is typical of many such units in the UK that are facing increasing competition from the commercial sector and Private Finance Initiatives, and at the same time, being driven by NHS initiatives towards having a demonstrable quality system. It was considered that having a recognized quality management system would ensure that the service provided was more efficient and effective, improve quality, guard against competition, be an asset if the organization was benchmarked against others, and provide evidence of quality assurance to our customers. This paper summarizes the history of quality management, discusses a number of quality systems in the NHS in general, and in Bradford Hospitals NHS Trust in particular, and puts forward the reasons for choosing ISO9001. Finally, the process leading to accreditation is described.

  16. Multiple performance measures are needed to evaluate triage systems in the emergency department.

    Science.gov (United States)

    Zachariasse, Joany M; Nieboer, Daan; Oostenbrink, Rianne; Moll, Henriëtte A; Steyerberg, Ewout W

    2018-02-01

    Emergency department triage systems can be considered prediction rules with an ordinal outcome, where different directions of misclassification have different clinical consequences. We evaluated strategies to compare the performance of triage systems and aimed to propose a set of performance measures that should be used in future studies. We identified performance measures based on literature review and expert knowledge. Their properties are illustrated in a case study evaluating two triage modifications in a cohort of 14,485 pediatric emergency department visits. Strengths and weaknesses of the performance measures were systematically appraised. Commonly reported performance measures are measures of statistical association (34/60 studies) and diagnostic accuracy (17/60 studies). The case study illustrates that none of the performance measures fulfills all criteria for triage evaluation. Decision curves are the performance measures with the most attractive features but require dichotomization. In addition, paired diagnostic accuracy measures can be recommended for dichotomized analysis, and the triage-weighted kappa and Nagelkerke's R 2 for ordinal analyses. Other performance measures provide limited additional information. When comparing modifications of triage systems, decision curves and diagnostic accuracy measures should be used in a dichotomized analysis, and the triage-weighted kappa and Nagelkerke's R 2 in an ordinal approach. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Emergency Department Visits Involving Nonmedical Use of Central Nervous System Stimulants among Adults Aged 18 to 34 ...

    Science.gov (United States)

    ... Emergency Department Visits Involving Nonmedical Use of Central Nervous System Stimulants among Adults Aged 18 to 34 Increased between 2005 and 2011 Central nervous system (CNS) stimulants include prescription drugs, like those used ...

  18. Regulation of vitamin D homeostasis: implications for the immune system.

    Science.gov (United States)

    van Etten, Evelyne; Stoffels, Katinka; Gysemans, Conny; Mathieu, Chantal; Overbergh, Lut

    2008-10-01

    Vitamin D homeostasis in the immune system is the focus of this review. The production of both the activating (25- and 1alpha-hydroxylase) and the metabolizing (24-hydroxylase) enzymes by cells of the immune system itself, indicates that 1,25(OH)(2)D(3) can be produced locally in immune reaction sites. Moreover, the strict regulation of these enzymes by immune signals is highly suggestive for an autocrine/paracrine role in the immune system, and opens new treatment possibilities.

  19. Liquid hydrogen transfer pipes and level regulation systems

    International Nuclear Information System (INIS)

    Marquet, M.; Prugne, P.; Roubeau, P.

    1961-01-01

    Describes: 1) Transfer pipes - Plunging rods in liquid hydrogen Dewars; transfer pipes: knee-joint system for quick and accurate positioning of plunging Dewar rods; system's rods: combined valve and rod; valves are activated either by a bulb pressure or by a solenoid automatically or hand controlled. The latter allows intermittent filling. 2) Level regulating systems: Level bulbs: accurate to 1 or 4 m; maximum and minimum level bulbs: automatic control of the liquid hydrogen valve. (author) [fr

  20. Current state and trend of radiation regulation system in Japan

    International Nuclear Information System (INIS)

    Yonehara, Hidenori

    2004-01-01

    Japanese regulation system for safety against radiation essentially started from 'Atomic Energy Basic Law' enacted in 1955 and 'Law Concerning Prevention of Radiation Hazards due to Radioisotopes, etc' enacted in 1957, has been regarded as a central rule for radiation protection and safety. Related laws and regulations have been enacted together with their revision. Radiation Council, established in the Science and Technology Agency in 1962 and now belonging to the Ministry of Education, Culture, Sports, Science and Technology, has deliberated basically on International Commission of Radiological Protection (ICRP) statements for legal revision and has set up working groups for current problems. Activities of the groups have concerned ICRP Publication 60 (1990) and later related publications for incorporating the principle into laws as to concepts of dose limits, effective dose, and then of exemption and exclusion. International status of the Japanese regulation, problems and tasks in the regulation are also commented. (N.I.)

  1. Pressure regulation system for modern gas-filled detectors

    International Nuclear Information System (INIS)

    McDonald, R.J.

    1986-08-01

    A gas pressure and flow regulation system has been designed and constructed to service a wide variety of gas-filled detectors which operate at pressures of ∼2 to 1000 Torr and flow rate of ∼5 to 200 standard cubic centimeters per minute (sccm). Pressure regulation is done at the detector input by a pressure transducer linked to a solenoid leak valve via an electronic control system. Gas flow is controlled via a mechanical leak valve at the detector output. Interchangeable transducers, flowmeters, and leak valves allow for different pressure and flow ranges. The differential pressure transducer and control system provide automatic let-up of vacuum chambers to atmospheric pressure while maintaining a controlled overpressure in the detector. The gas system is constructed on a standard 19'' rack-mounted panel from commercially available parts. Five of these systems have been built and are routinely used for both ionization chambers and position-sensitive avalanche detectors

  2. Potential nuclear material safeguards applied to the Department of Energy's Civilian Radioactive Waste Management System

    International Nuclear Information System (INIS)

    Danker, W.J.; Floyd, W.

    1993-01-01

    The Office of Civilian Radioactive Waste Management (OCRWM) within the U.S. Department of Energy is charged with the responsibility of safe and efficient disposal of this Nation's civilian high-level radioactive waste and spent fuel. Part of this responsibility includes providing for the application of both domestic and international safeguards on nuclear material at facilities of the Civilian Waste Management System. While detailed safeguards requirements for these disposal facilities have yet to be established, once established, they could impact facility design. Accordingly, OCRWM has participated in efforts to develop safeguards approaches for geologic repositories and will continue to participate actively with the Nuclear Regulatory Commission (NRC), International Atomic Energy Agency (IAEA), as well as other Department of Energy (DOE) Offices in efforts to resolve safeguards issues related to spent fuel disposal, to minimize any potential design impacts and to support effective nuclear material safeguards. The following paper discusses current plants and issues related to the application of safeguards to the Civilian Radioactive Waste Management System (CRWMS)

  3. 2014 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

    CERN Document Server

    Barbin, Lucie; CERN. Geneva. HR Department

    2015-01-01

    The 2014 Annual Report under Chapter VI ("Settlement of Disputes and Discipline") of the Staff Rules and Regulations (SRR) serves to report cases of submission of requests for review, internal appeals, complaints with the ILOAT, and cases in which disciplinary action was taken.

  4. 2012 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

    CERN Document Server

    Schepens, A; CERN. Geneva. HR Department

    1013-01-01

    The 2012 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations (SRR) serves to report cases of submission of requests for review, internal appeals, appeals to the ILOAT, and cases in which disciplinary action was taken.

  5. 2015 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

    CERN Document Server

    Lalande, Amanda

    2016-01-01

    The 2015 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations serves to report cases of submission of requests for review; internal appeals; complaints before the Administrative Tribunal of the International Labour Organization (ILOAT); and cases in which disciplinary action was taken.

  6. 2016 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

    CERN Document Server

    Lalande, Amanda

    2017-01-01

    The 2016 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations serves to report cases of submission of requests for review; internal appeals; complaints before the Administrative Tribunal of the International Labour Organization (ILOAT); and cases in which disciplinary action was taken.

  7. 2011 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

    CERN Document Server

    Schepens, A; CERN. Geneva. HR Department

    2012-01-01

    The 2011 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations (SRR) serves to report cases of submission of requests for review, internal appeals, appeals to the ILOAT, and cases in which disciplinary action was taken.

  8. The Role of the IT Department in Information System and Organizational Redesign.

    Science.gov (United States)

    Stub Petersen, Lone

    2015-01-01

    This paper is based on a qualitative study of IT organization and clinical practice over a period of 3 years supported by additional data during the last 2 years. This paper argues that redesign is central to understanding and developing both healthcare information systems and organizations. The importance of the IT organization is also stressed throughout this paper as a pertinent partner and power when considering organizational change and learning in hospitals as it can serve both as a barrier and a catalyst of change and flexibility in the organization through information systems management. Therefore it is important to consider and secure appropriate forms for redesign and learning in cooperation with the IT department.

  9. Results of the implementation of a learning system with incidents in an radiotherapy department

    International Nuclear Information System (INIS)

    Radicchi, Lucas Augusto; Vilela, Ellen Pedroso Severino; Faustino, Fabio de Lima C.; Rodrigues, Fernanda Arantes C.; Gomes, Franciele N.; Souza, Guilherme Vicente de; Silva, Rose Marta S.; Toledo, Jose Carlos de

    2016-01-01

    An incident learning system (ILS) is an important tool for improving aspects of patient and staff safety. In radiation oncology, ILS has been implemented both at the institutional level as at the national level, allowing to share lessons learned from incidents that have already occurred. The objective of this study is to present the preliminary results of the ILS implemented in a radiation oncology department. In total, 128 incidents were reviewed by a multidisciplinary committee, and the professional groups that registered more were medical physicists, radiation oncologists and radiation therapists. In addition, incidents have occurred and have been detected mainly in the treatment step. The incident learning system proved to be an important process improvement tool, according to the results shown,the improvement actions proposed and the perception of the people involved. (author)

  10. Integrated Thermal Treatment Systems study: US Department of Energy Internal Review Panel report

    International Nuclear Information System (INIS)

    Cudahy, J.; Escarda, T.; Gimpel, R.

    1995-04-01

    The U.S. Department of Energy's (DOE) Office of Technology Development (OTD) commissioned two studies to uniformly evaluate nineteen thermal treatment technologies. These studies were called the Integrated Thermal Treatment System (ITTS) Phase I and Phase II. With the advice and guidance of the DOE Office of Environmental Management's (EM's) Mixed Waste Focus Group, OTD formed an ITTS Internal Review Panel, composed of scientists and engineers from throughout the DOE complex, the U.S. Environmental Protection Agency (EPA), the California EPA, and private experts. The Panel met from November 15-18, 1994, to review and comment on the ITTS studies, to make recommendations on the most promising thermal treatment systems for DOE mixed low level wastes (MLLW), and to make recommendations on research and development necessary to prove the performance of the technologies on MLLW

  11. Design of the Information Science and Systems (IS Curriculum in a Computer and Information Sciences Department

    Directory of Open Access Journals (Sweden)

    Behrooz Seyed-Abbassi

    2004-12-01

    Full Text Available Continuous technological changes have resulted in a rapid turnover of knowledge in the computing field. The impact of these changes directly affects the computer-related curriculum offered by educational institutions and dictates that curriculum must evolve to keep pace with technology and to provide students with the skills required by businesses. At the same time, accreditations of curricula from reviewing organizations provide additional guidelines and standardization for computing science as well as information science programs. One of the areas significantly affected by these changes is the field of information systems. This paper describes the evaluation and course structure for the undergraduate information science and systems program in the Computer and Information Sciences Department at the University of North Florida. A list of the major required and elective courses as well as an overview of the challenges encountered during the revision of the curriculum is given.

  12. State and use of monitoring and evaluation systems in national and provincial departments

    Directory of Open Access Journals (Sweden)

    Futhi Umlaw

    2015-09-01

    Full Text Available Since 2009, South Africa has seen a major shift in emphasis concerning monitoring and evaluation (M&E systems. This shift was partially stimulated by the South African government being faced with a number of pressures, key amongst which were persistent poverty and inequality and widespread service delivery protests. These pressures resulted ina greater willingness by government to address the poor quality of public services, and other governance problems that needed a greater focus on M&E to address these challenges. This led to the establishment of the Department of Performance Monitoring and Evaluation (DPME in early 2010. A comprehensive survey on the state and use of M&E systems in national and provincial government was conducted by the DPME as an attempt to understand the M&E landscape since 1994. The results were used to make informed policy and programme decisions. This paper outlines the findings of the survey.

  13. US Department of Energy, Richland Operations Office Integrated Safety Management System Program Description

    International Nuclear Information System (INIS)

    SHOOP, D.S.

    2000-01-01

    The purpose of this Integrated Safety Management System (ISMS) Program Description (PD) is to describe the U.S. Department of Energy (DOE), Richland Operations Office (RL) ISMS as implemented through the RL Integrated Management System (RIMS). This PD does not impose additional requirements but rather provides an overview describing how various parts of the ISMS fit together. Specific requirements for each of the core functions and guiding principles are established in other implementing processes, procedures, and program descriptions that comprise RIMS. RL is organized to conduct work through operating contracts; therefore, it is extremely difficult to provide an adequate ISMS description that only addresses RL functions. Of necessity, this PD contains some information on contractor processes and procedures which then require RL approval or oversight

  14. Approaches Mediating Oxytocin Regulation of the Immune System.

    Science.gov (United States)

    Li, Tong; Wang, Ping; Wang, Stephani C; Wang, Yu-Feng

    2016-01-01

    The hypothalamic neuroendocrine system is mainly composed of the neural structures regulating hormone secretion from the pituitary gland and has been considered as the higher regulatory center of the immune system. Recently, the hypothalamo-neurohypophysial system (HNS) emerged as an important component of neuroendocrine-immune network, wherein the oxytocin (OT)-secreting system (OSS) plays an essential role. The OSS, consisting of OT neurons in the supraoptic nucleus, paraventricular nucleus, their several accessory nuclei and associated structures, can integrate neural, endocrine, metabolic, and immune information and plays a pivotal role in the development and functions of the immune system. The OSS can promote the development of thymus and bone marrow, perform immune surveillance, strengthen immune defense, and maintain immune homeostasis. Correspondingly, OT can inhibit inflammation, exert antibiotic-like effect, promote wound healing and regeneration, and suppress stress-associated immune disorders. In this process, the OSS can release OT to act on immune system directly by activating OT receptors or through modulating activities of other hypothalamic-pituitary-immune axes and autonomic nervous system indirectly. However, our understandings of the role of the OSS in neuroendocrine regulation of immune system are largely incomplete, particularly its relationship with other hypothalamic-pituitary-immune axes and the vasopressin-secreting system that coexists with the OSS in the HNS. In addition, it remains unclear about the relationship between the OSS and peripherally produced OT in immune regulation, particularly intrathymic OT that is known to elicit central immunological self-tolerance of T-cells to hypophysial hormones. In this work, we provide a brief review of current knowledge of the features of OSS regulation of the immune system and of potential approaches that mediate OSS coordination of the activities of entire neuroendocrine-immune network.

  15. USA IN THE EMERGING SYSTEM OF GLOBAL FINANCIAL REGULATION

    Directory of Open Access Journals (Sweden)

    V. K. Kulakova

    2016-01-01

    Full Text Available In the globalizing world of fi nancial and economic interdependence, a polycentric, multi-level, and hierarchical system of global financial regulation is emerging. The article highlights two vectors of recent development in international fi nancial regulation: the rise of cooperation through the mechanisms of the Group of Twenty (G-20 on the one hand, and the efforts to maintain the US leading role in global fi nance, on the other hand. In the circumstances of the global fi nancial crisis of 2008, the G-20 countries initiated an international reform of fi nancial regulation. According to G-20 decisions, international standardsetting organizations developed transnational regulatory regimes in the fi elds of banking, derivatives and bankruptcy resolution, and the states now implement these regimes in their jurisdictions. The so-called “soft law system”, which is not legally binding, allows the states to sustain national sovereignty in their fi nancial policy. The United States play a leading role in the international fi nancial reform, as well as in the shaping of the global fi nancial regulation system. The American regulators push for extraterritorial application of the US norms and take other unilateral actions on the international arena. The article also touches upon legitimacy problems of the emerging system of global fi nancial regulation. The most important constrains are the excessive infl uence of the fi nancial industry (“regulatory capture”, the weakness of civil society participation, and also the fact that for the rest of the world the American norms lack legitimacy, as they are adopted by regulators assigned by offi cials elected by population of a foreign territory.

  16. The RPI-X system of regulation and British Gas

    International Nuclear Information System (INIS)

    Spring, P.

    1992-01-01

    The RPI-X system of regulation was subject to a theoretical examination in a previous paper 'The RPI-X system of price-capping regulation re-examined'. The practical example of British Gas shows that what started out as a simple formula can become a complex hybrid lacking in transparency. The formula has properties which mean that its impact can be harsher or lighter depending on exogenous factors which the regulated company cannot be entirely or reasonably expected to predict or control. In the first five years - 1987 to 1992 -of the formula's application, when X was set at a very undemanding 2%, the surge in the RPI, resulted in a virtual windfall increase in profits. In the second five years 1992 to 1997 - X has been reset at a much more demanding 5%. Also, new terms for gas costs (GPI-Z) and energy efficiency (E) have been introduced which are quite lacking in transparency. (author)

  17. Dynamic Model of Kaplan Turbine Regulating System Suitable for Power System Analysis

    OpenAIRE

    Zhao, Jie; Wang, Li; Liu, Dichen; Wang, Jun; Zhao, Yu; Liu, Tian; Wang, Haoyu

    2015-01-01

    Accurate modeling of Kaplan turbine regulating system is of great significance for grid security and stability analysis. In this paper, Kaplan turbine regulating system model is divided into the governor system model, the blade control system model, and the turbine and water diversion system model. The Kaplan turbine has its particularity, and the on-cam relationship between the wicket gate opening and the runner blade angle under a certain water head on the whole range was obtained by high-o...

  18. Evaluation of Syndromic Surveillance Systems in 6 US State and Local Health Departments.

    Science.gov (United States)

    Thomas, Mathew J; Yoon, Paula W; Collins, James M; Davidson, Arthur J; Mac Kenzie, William R

    Evaluating public health surveillance systems is critical to ensuring that conditions of public health importance are appropriately monitored. Our objectives were to qualitatively evaluate 6 state and local health departments that were early adopters of syndromic surveillance in order to (1) understand the characteristics and current uses, (2) identify the most and least useful syndromes to monitor, (3) gauge the utility for early warning and outbreak detection, and (4) assess how syndromic surveillance impacted their daily decision making. We adapted evaluation guidelines from the Centers for Disease Control and Prevention and gathered input from the Centers for Disease Control and Prevention subject matter experts in public health surveillance to develop a questionnaire. We interviewed staff members from a convenience sample of 6 local and state health departments with syndromic surveillance programs that had been in operation for more than 10 years. Three of the 6 interviewees provided an example of using syndromic surveillance to identify an outbreak (ie, cluster of foodborne illness in 1 jurisdiction) or detect a surge in cases for seasonal conditions (eg, influenza in 2 jurisdictions) prior to traditional, disease-specific systems. Although all interviewees noted that syndromic surveillance has not been routinely useful or efficient for early outbreak detection or case finding in their jurisdictions, all agreed that the information can be used to improve their understanding of dynamic disease control environments and conditions (eg, situational awareness) in their communities. In the jurisdictions studied, syndromic surveillance may be useful for monitoring the spread and intensity of large outbreaks of disease, especially influenza; enhancing public health awareness of mass gatherings and natural disasters; and assessing new, otherwise unmonitored conditions when real-time alternatives are unavailable. Future studies should explore opportunities to

  19. Order of draw practices in venous blood sampling at clinical biochemistry departments in the Danish health care system

    DEFF Research Database (Denmark)

    Jacobsen, Katja Kemp; Brandt, Ida; Christensen, Anne Vindahl

    2018-01-01

    the procedures in venous blood sampling among clinical biochemistry departments to assess the uniformity of order of blood draw and adherence to international guidelines in the Danish health care system. METHODS: We collected venous order of draw procedures from 49 clinical biochemistry departments at 22 public...... 15189:2012 accreditation (p = .57). CONCLUSIONS: Venous order of draw procedures is diverse at Danish clinical biochemistry departments and show moderate adherence to international guidelines....

  20. Interoperability of Information Systems Managed and Used by the Local Health Departments.

    Science.gov (United States)

    Shah, Gulzar H; Leider, Jonathon P; Luo, Huabin; Kaur, Ravneet

    2016-01-01

    In the post-Affordable Care Act era marked by interorganizational collaborations and availability of large amounts of electronic data from other community partners, it is imperative to assess the interoperability of information systems used by the local health departments (LHDs). To describe the level of interoperability of LHD information systems and identify factors associated with lack of interoperability. This mixed-methods research uses data from the 2015 Informatics Capacity and Needs Assessment Survey, with a target population of all LHDs in the United States. A representative sample of 650 LHDs was drawn using a stratified random sampling design. A total of 324 completed responses were received (50% response rate). Qualitative data were used from a key informant interview study of LHD informatics staff from across the United States. Qualitative data were independently coded by 2 researchers and analyzed thematically. Survey data were cleaned, bivariate comparisons were conducted, and a multivariable logistic regression was run to characterize factors associated with interoperability. For 30% of LHDs, no systems were interoperable, and 38% of LHD respondents indicated some of the systems were interoperable. Significant determinants of interoperability included LHDs having leadership support (adjusted odds ratio [AOR] = 3.54), control of information technology budget allocation (AOR = 2.48), control of data systems (AOR = 2.31), having a strategic plan for information systems (AOR = 1.92), and existence of business process analysis and redesign (AOR = 1.49). Interoperability of all systems may be an informatics goal, but only a small proportion of LHDs reported having interoperable systems, pointing to a substantial need among LHDs nationwide.

  1. Emotion regulation and conflict transformation in multi-team systems

    NARCIS (Netherlands)

    Curseu, P.L.; Meeus, M.T.H.

    2014-01-01

    Purpose The aim of this paper is to test the moderating role of emotion regulation in the transformation of both task and process conflict into relationship conflict. Design/methodology/approach A field study of multi-teams systems, in which (94) respondents are engaged in interpersonal and

  2. Osmosensory mechanisms in cellular and systemic volume regulation

    DEFF Research Database (Denmark)

    Pedersen, Stine Helene Falsig; Kapus, András; Hoffmann, Else K

    2011-01-01

    Perturbations of cellular and systemic osmolarity severely challenge the function of all organisms and are consequently regulated very tightly. Here we outline current evidence on how cells sense volume perturbations, with particular focus on mechanisms relevant to the kidneys and to extracellular...

  3. Reconstructing a Network of Stress-Response Regulators via Dynamic System Modeling of Gene Regulation

    Directory of Open Access Journals (Sweden)

    Wei-Sheng Wu

    2008-01-01

    Full Text Available Unicellular organisms such as yeasts have evolved mechanisms to respond to environmental stresses by rapidly reorganizing the gene expression program. Although many stress-response genes in yeast have been discovered by DNA microarrays, the stress-response transcription factors (TFs that regulate these stress-response genes remain to be investigated. In this study, we use a dynamic system model of gene regulation to describe the mechanism of how TFs may control a gene’s expression. Then, based on the dynamic system model, we develop the Stress Regulator Identification Algorithm (SRIA to identify stress-response TFs for six kinds of stresses. We identified some general stress-response TFs that respond to various stresses and some specific stress-response TFs that respond to one specifi c stress. The biological significance of our findings is validated by the literature. We found that a small number of TFs is probably suffi cient to control a wide variety of expression patterns in yeast under different stresses. Two implications can be inferred from this observation. First, the response mechanisms to different stresses may have a bow-tie structure. Second, there may be regulatory cross-talks among different stress responses. In conclusion, this study proposes a network of stress-response regulators and the details of their actions.

  4. A systematic review of patient tracking systems for use in the pediatric emergency department.

    Science.gov (United States)

    Dobson, Ian; Doan, Quynh; Hung, Geoffrey

    2013-01-01

    Patient safety is of great importance in the pediatric emergency department (PED). The combination of acutely and critically ill patients and high patient volumes creates a need for systems to support physicians in making accurate and timely diagnoses. Electronic patient tracking systems can potentially improve PED safety by reducing overcrowding and enhancing security. To enhance our understanding of current electronic tracking technologies, how they are implemented in a clinical setting, and resulting effect on patient care outcomes including patient safety. Nine databases were searched. Two independent reviewers identified articles that contained reference to patient tracking technologies in pediatrics or emergency medicine. Quantitative studies were assessed independently for methodological strength by two reviewers using an external assessment tool. Of 2292 initial articles, 22 were deemed relevant. Seventeen were qualitative, and the remaining five quantitative articles were assessed as being methodologically weak. Existing patient tracking systems in the ED included: infant monitoring/abduction prevention; barcode identification; radiofrequency identification (RFID)- or infrared (IR)-based patient tracking. Twenty articles supported the use of tracking technology to enhance patient safety or improve efficiency. One article failed to support the use of IR patient sensors due to study design flaws. Support exists for the use of barcode-, IR-, and RFID-based patient tracking systems to improve ED patient safety and efficiency. A lack of methodologically strong studies indicates a need for further evidence-based support for the implementation of patient tracking technology in a clinical or research setting. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. System design and improvement of an emergency department using Simulation-Based Multi-Objective Optimization

    International Nuclear Information System (INIS)

    Uriarte, A Goienetxea; Zúñiga, E Ruiz; Moris, M Urenda; Ng, A H C

    2015-01-01

    Discrete Event Simulation (DES) is nowadays widely used to support decision makers in system analysis and improvement. However, the use of simulation for improving stochastic logistic processes is not common among healthcare providers. The process of improving healthcare systems involves the necessity to deal with trade-off optimal solutions that take into consideration a multiple number of variables and objectives. Complementing DES with Multi-Objective Optimization (SMO) creates a superior base for finding these solutions and in consequence, facilitates the decision-making process. This paper presents how SMO has been applied for system improvement analysis in a Swedish Emergency Department (ED). A significant number of input variables, constraints and objectives were considered when defining the optimization problem. As a result of the project, the decision makers were provided with a range of optimal solutions which reduces considerably the length of stay and waiting times for the ED patients. SMO has proved to be an appropriate technique to support healthcare system design and improvement processes. A key factor for the success of this project has been the involvement and engagement of the stakeholders during the whole process. (paper)

  6. [Impact of an automated dispensing system for medical devices in cardiac surgery department].

    Science.gov (United States)

    Clou, E; Dompnier, M; Kably, B; Leplay, C; Poupon, E; Archer, V; Paul, M

    2018-01-01

    To secure medical devices' management, the implementation of automated dispensing system in surgical service has been realized. The objective of this study was to evaluate security, organizational and economic impact of installing automated dispensing system for medical devices (ASDM). The implementation took place in a cardiac surgery department. Security impact was assessed by comparing traceability rate of implantable medical devices one year before and one year after installation. Questionnaire on nurses' perception and satisfaction completed this survey. Resupplying costs, stocks' evolution and investments for the implementation of ASDM were the subject of cost-benefit study. After one year, traceability rate is excellent (100%). Nursing staffs were satisfied with 87.5% by this new system. The introduction of ASDM allowed a qualitative and quantitative decrease in stocks, with a reduction of 30% for purchased medical devices and 15% for implantable medical devices in deposit-consignment. Cost-benefit analysis shows a rapid return on investment. Real stock decrease (purchased medical devices) is equivalent to 46.6% of investment. Implementation of ASDM allows to secure storage and dispensing of medical devices. This system has also an important economic impact and appreciated by users. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

  7. 75 FR 8088 - Privacy Act of 1974; Department of Homeland Security/ALL-023 Personnel Security Management System...

    Science.gov (United States)

    2010-02-23

    ... risk of harm to economic or property interests, identity theft or fraud, or harm to the security or... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2009-0041] Privacy Act of 1974; Department of Homeland Security/ALL--023 Personnel Security Management System of Records AGENCY...

  8. Legislation and regulation of nuclear activities. Volume 2. Texts published by the Legal Affairs Department of the Atomic Energy Commission

    International Nuclear Information System (INIS)

    1994-01-01

    This is the second edition of the 1983 compilation of legislative texts and regulations published by the french Atomic Energy Commission (CEA). It provides a comprehensive source of knowledge and information on nuclear energy laws. Since the first edition environmental aspects have been pointed out. Texts upon transportation have been added. Public enquires procedures have been modified since 1983 law to improve transparency. This volume has five chapters: (E) environment and man protection; (F) wastes; (G) responsibility and damage repair; (H) knowledge acquisition, protection and broadcast; (I) international cooperation. (D.L.)

  9. US Department of Energy Laboratory Accreditation Program for personnel dosimetry systems (DOELAP)

    International Nuclear Information System (INIS)

    Carlson, R.D.; Gesell, T.F.; Kalbeitzer, F.L.; Roberson, P.L.; Jones, K.L.; MacDonald, J.C.; Vallario, E.J.; Pacific Northwest Lab., Richland, WA; USDOE Assistant Secretary for Nuclear Energy, Washington, DC

    1988-01-01

    The US Department of Energy (DOE) Office of Nuclear Safety has developed and initiated the DOE Laboratory Accreditation Program (DOELAP) for personnel dosimetry systems to assure and improve the quality of personnel dosimetry at DOE and DOE contractor facilities. It consists of a performance evaluation program that measures current performance and an applied research program that evaluates and recommends additional or improved test and performance criteria. It also provides guidance to DOE, identifying areas where technological improvements are needed. The two performance evaluation elements in the accreditation process are performance testing and onsite assessment by technical experts. Performance testing evaluates the participant's ability to accurately and reproducibly measure dose equivalent. Tests are conducted in accident level categories for low- and high-energy photons as well as protection level categories for low- and high-energy photons, beta particles, neutrons and mixtures of these

  10. Diatoms from lentic and lotic systems in Antioquia, Choco and Santander Departments in Colombia

    International Nuclear Information System (INIS)

    Sala, Silvia E.; Ramirez, John J.; Plata, Yasmin

    2008-01-01

    In the tropical and subtropical regions, there is a large number of species which has not been yet described. The high possibility of extinction makes their inventory a priority. 23 diatoms taxa from Andean lotic systems and lentic waterbodies localized in the Departments of Antioquia, Santander and Choco, Colombia, are analyzed with light and scanning electron microscopy. Each taxon is described and information about environmental characteristic of the sites where they were collected and distribution in Colombia is given. The studied taxa belong to the orders Thalassiosirales (1), Aulacoseirales (1), Fragilariales (4), Cymbellales (7), Achnanthales (2), Naviculales (7), and Thalassiophysales (1). Fifteen of them are recorded for the first time in Colombia and Encyonema jemtlandicum in America del Sur. A comparison with the diatom flora of the Colombian Amazonia showed that there were only three taxa in common to these two equatorial regions probably due to the influence of altitudinal gradient. (author)

  11. Implementation of an assurance system guarantee quality in the hospital radiotherapy department of Lenin Holguin, Cuba

    International Nuclear Information System (INIS)

    Gonzalez Lopez, Nadia; Perez Velasquez, Reytel; Sol Zamora

    2009-01-01

    By the need to develop a simple and effective method of reducing radiation accidents in the present work has as objective the implementation through a manual system assurance quality assurance department of radiotherapy based on ISO 9000 and 14000 , besides the IAEA TECDOC-1151. The Quality Manual is divided into four sessions: general, procedures for the realization of security testing, mechanical and dosimetric the Co-60 machine, procedures for the planning of treatments in gynecology locations, SNC, rectum and breast cancer and those relating to the search and / or simulation of the first patient treatment, all discussed and approved by the Quality Assurance Committee. We conclude that this document is essential in obtaining an increasing quality in conventional radiation treatments, plus must be a reference material in the training of technologists, doctors and medical physicist and the documentary basis for the conformation of the warranty program quality of radiation therapy 3D-CRT. (author)

  12. Implementation of the quality management system ISO CD2 9001-2000 in a radiology department

    International Nuclear Information System (INIS)

    Fleisch, M.; Hergan, K.; Oser, W.

    2000-01-01

    Quality assurance in health care, a relatively new discipline, has developed rapidly over the last years and is now required by law. The Quality Management System (QMS) ISO 9001 aims at the definition of requirements necessary in order to achieve perfect products and continuous quality improvement. Implementation of this QMS necessitates the analysis and written documentation of all working processes and modes of operation. Furthermore, potential improvement possibilities are defined to guarantee highly qualified, generally applicable and standardised procedures. Time-consuming data assessment is an instrument to enable disclosure and analysis of existing errors as well as to show possibilities of optimization, thus forming the basis for continuous improvement. The new ISO NORM 9001-2000 is process-orientated with an organisational structure strongly recommendable for service institutions and therefore also for a department of radiology. (orig.) [de

  13. US Department of Energy Mixed Waste Integrated Program performance systems analysis

    International Nuclear Information System (INIS)

    Ferrada, J.J.; Berry, J.B.

    1994-01-01

    The primary goal of this project is to support decision making for the U.S. Department of Energy (DOE)/EM-50 Mixed Waste Integrated Program (MWIP) and the Mixed Low-Level Waste Program. A systems approach to the assessment of enhanced waste form(s) production will be employed including, coordination and configuration management of activities in specific technology development tasks. The purpose of this paper is to describe the development and application of a methodology for implementing a performance systems analysis on mixed waste treatment process technologies. The second section describes a conventional approach to process systems analysis followed by a methodology to estimate uncertainties when analyzing innovative technologies. Principles from these methodologies have been used to develop a performance systems analysis for MWIP. The third section describes the systems analysis tools. The fourth section explains how the performance systems analysis will be used to analyze MWIP process alternatives. The fifth and sixth sections summarize this paper and describe future work for this project. Baseline treatment process technologies (i.e., commercially available technologies) and waste management strategies are evaluated systematically using the ASPEN PLUS program applications developed by the DOE Mixed Waste Treatment Project (MWTP). Alternatives to the baseline (i.e., technologies developed by DOE's Office of Technology Development) are analyzed using FLOW, a user-friendly program developed at Oak Ridge National Laboratory (ORNL). Currently, this program is capable of calculating rough order-of-magnitude mass and energy balances to assess the performance of the alternative technologies as compared to the baseline process. In the future, FLOW will be capable of communicating information to the ASPEN PLUS program

  14. Characterization and typification of citrus production systems in the department of Meta

    Directory of Open Access Journals (Sweden)

    José Alejandro Cleves-Leguízamo

    2014-04-01

    Full Text Available Agriculture is a co-evolutionary process between society and nature. Agroecology is an environmental science which focuses on ecosystem-culture and society-nature interactive systems, the effect of human intervention in the transformation of ecosystems. The central objects are agroecosystems and the units of study are production units. These production units are conceived of as agricultural systems and are found in the crossroads of multiple interactions between biophysical, socioeconomical, cultural, and production components, which must be analyzed with an integrated concept. In the present study, a characterization and typification of the citrus agroecosystems of the department of Meta were pursued (Colombia. The pertinence of implementing the methodology designed by the Latin-American Center for Rural Development (Centro Latinoamericano para el Desarrollo Rural-RIMISP was evaluated, grouping the variables with a focus on an analysis of livelihoods. A survey and interview were defined as methods of collecting the primary information in the municipalities of Puerto López, Villavicencio, Granada, Lejanías, Guamal and San Martin, where 78.4% of the citrus area of the department is found. This study involved the selection and definition of the evaluation variables, validation and adjustment of said variables, collection of primary and secondary information, and the application of multivariate statistical analysis techniques to conform and characterize the recommendation domains or groups. The more important results indicated that it is possible to increase knowledge of the interrelations that exist between the different components of farm agroecosystems and their relationship with the principal agroecological structure. The existence of six agricultural groups or recommendation domains was established, with some productive characteristics very similar within the group but very heterogeneous to the outside of the group, with particular

  15. Activation of ion transport systems during cell volume regulation

    International Nuclear Information System (INIS)

    Eveloff, J.L.; Warnock, D.G.

    1987-01-01

    This review discusses the activation of transport pathways during volume regulation, including their characteristics, the possible biochemical pathways that may mediate the activation of transport pathways, and the relations between volume regulation and transepithelial transport in renal cells. Many cells regulate their volume when exposed to an anisotonic medium. The changes in cell volume are caused by activation of ion transport pathways, plus the accompanying osmotically driven water movement such that cell volume returns toward normal levels. The swelling of hypertonically shrunken cells is termed regulatory volume increase (RVI) and involves an influx of NaCl into the cell via either activation of Na-Cl, Na-K-2Cl cotransport systems, or Na + -H + and Cl - -HCO 3 - exchangers. The reshrinking of hypotonically swollen cells is termed regulatory volume decrease (RVD) and involves an efflux of KCl and water from the cell by activation of either separate K + and Cl - conductances, a K-Cl cotransport system, or parallel K + -H + and Cl - -HCO 3 - exchangers. The biochemical mechanisms involved in the activation of transport systems are largely unknown, however, the phosphoinositide pathway may be implicated in RVI; phorbol esters, cGMP, and Ca 2+ affect the process of volume regulation. Renal tubular cells, as well as the blood cells that transverse the medulla, are subjected to increasing osmotic gradients from the corticomedullary junction to the papillary tip, as well as changing interstitial and tubule fluid osmolarity, depending on the diuretic state of the animal. Medullary cells from the loop of Henle and the papilla can volume regulate by activating Na-K-2Cl cotransport or Na + -H + and Cl - -HCO 3 - exchange systems

  16. The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic Regulation

    Science.gov (United States)

    Wu, Haijing; Zhao, Ming; Chang, Christopher; Lu, Qianjin

    2015-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs and the presence of anti-nuclear antibodies. The pathogenesis of SLE has been intensively studied but remains far from clear. B and T lymphocyte abnormalities, dysregulation of apoptosis, defects in the clearance of apoptotic materials, and various genetic and epigenetic factors are attributed to the development of SLE. The latest research findings point to the association between abnormal epigenetic regulation and SLE, which has attracted considerable interest worldwide. It is the purpose of this review to present and discuss the relationship between aberrant epigenetic regulation and SLE, including DNA methylation, histone modifications and microRNAs in patients with SLE, the possible mechanisms of immune dysfunction caused by epigenetic changes, and to better understand the roles of aberrant epigenetic regulation in the initiation and development of SLE and to provide an insight into the related therapeutic options in SLE. PMID:25988383

  17. Performance of the internal audit department under ERP systems: empirical evidence from Taiwanese firms

    Science.gov (United States)

    Tsai, Wen-Hsien; Chen, Hui-Chiao; Chang, Jui-Chu; Leu, Jun-Der; Chao Chen, Der; Purbokusumo, Yuyun

    2015-10-01

    In this study, the performance of the internal audit department (IAD) and its contribution to a company under enterprise resource planning (ERP) systems was examined. It is anticipated that this will provide insight into the factors perceived to be crucial to a company's effectiveness. A theoretical framework was developed and tested using the sample of Taiwanese companies. Using mail survey procedures, we elicited perceptions from key internal auditors about the ERP system and auditing software, as well as their opinions concerning the IAD's effectiveness and its contribution within a company. Data were analysed using the partial least square (PLS) regression to test the hypotheses. Drawing upon a sample of Taiwanese firms, the study suggests that a firm can improve the performance of the IAD through an enterprise-wide integrated, effective ERP system and appropriate auditing software. At the same time, the performance of the IAD can also contribute significantly to the company. The results also show that investments in computer-assisted auditing techniques (CAATs) are crucial due to their tremendous effectiveness in regard to the performance of the IAD and for the contributions CAATs can make to a company.

  18. Material handling systems for use in glovebox lines: A survey of Department of Energy facility experience

    International Nuclear Information System (INIS)

    Teese, G.D.; Randall, W.J.

    1992-01-01

    The Nuclear Weapons Complex Reconfiguration Study has recommended that a new manufacturing facility be constructed to replace the Rocky Flats Plant. In the new facility, use of an automated material handling system for movement of components would reduce both the cost and radiation exposure associated with production and maintenance operations. Contamination control would be improved between process steps through the use of airlocks and portals. Part damage associated with improper transport would be reduced, and accountability would be increased. In-process workpieces could be stored in a secure vault, awaiting a request for parts at a production station. However, all of these desirable features rely on the proper implementation of an automated material handling system. The Department of Energy Weapons Production Complex has experience with a variety of methods for transporting discrete parts in glovebox lines. The authors visited several sites to evaluate the existing technologies for their suitability for the application of plutonium manufacturing. Technologies reviewed were Linear motors, belt conveyors, roller conveyors, accumulating roller conveyors, pneumatic transport, and cart systems. The sites visited were The Idaho National Engineering laboratory, the Hanford Site, and the Rocky Flats Plant. Linear motors appear to be the most promising technology observed for the movement of discrete parts, and further investigation is recommended

  19. USE OF MARK-RATING SYSTEM IN ESTIMATION OF PROFESSIONAL COMPETENCE OF STUDENTS OF PEDIATRIC DEPARTMENT DURING PROFESSIONAL PRACTICE

    Directory of Open Access Journals (Sweden)

    Gumenyuk O.I.

    2009-03-01

    Full Text Available In this article the authors demonstrate the results of using mark-rating system in estimation of professional competence of the fifth-year students of pediatric department during summer professional practice.

  20. Modeling and simulation of CANDU reactor and its regulating system

    Science.gov (United States)

    Javidnia, Hooman

    Analytical computer codes are indispensable tools in design, optimization, and control of nuclear power plants. Numerous codes have been developed to perform different types of analyses related to the nuclear power plants. A large number of these codes are designed to perform safety analyses. In the context of safety analyses, the control system is often neglected. Although there are good reasons for such a decision, that does not mean that the study of control systems in the nuclear power plants should be neglected altogether. In this thesis, a proof of concept code is developed as a tool that can be used in the design. optimization. and operation stages of the control system. The main objective in the design of this computer code is providing a tool that is easy to use by its target audience and is capable of producing high fidelity results that can be trusted to design the control system and optimize its performance. Since the overall plant control system covers a very wide range of processes, in this thesis the focus has been on one particular module of the the overall plant control system, namely, the reactor regulating system. The center of the reactor regulating system is the CANDU reactor. A nodal model for the reactor is used to represent the spatial neutronic kinetics of the core. The nodal model produces better results compared to the point kinetics model which is often used in the design and analysis of control system for nuclear reactors. The model can capture the spatial effects to some extent. although it is not as detailed as the finite difference methods. The criteria for choosing a nodal model of the core are: (1) the model should provide more detail than point kinetics and capture spatial effects, (2) it should not be too complex or overly detailed to slow down the simulation and provide details that are extraneous or unnecessary for a control engineer. Other than the reactor itself, there are auxiliary models that describe dynamics of different

  1. Performance comparisons of selected personnel-dosimetry systems in use at Department of Energy facilities

    International Nuclear Information System (INIS)

    Roberson, P.L; Holbrook, K.L.; Yoder, R.C.; Fox, R.A.; Hadley, R.T.; Hogan, B.T.; Hooker, C.D.

    1983-10-01

    Dosimeter performance data were collected to help develop a uniform approach to the calibration and use of personnel dosimetry systems for Department of Energy (DOE) laboratories. Eleven DOE laboratories participated in six months of testing using the American National Draft Standard, Criteria for Testing Personnel Dosimetry Performance, ANSI N13.11, and additional testing categories. The tests described in ANSI N13.11 used a pass/fail system to determine compliance with the draft standard. Recalculation to PNL irradiations showed that the 137 Cs, 90 Sr/ 90 Y, and 252 Cf categories can be recalibrated to have acceptable performance for nearly all participant systems. Deficient dosimeter design or handling techniques caused poor performance in the x-ray category for nearly half of the participants. Too little filtration for the deep-dose element caused poor performance in the beta/photon mixture category for one participant. Two participants had excessively high standard deviations in the neutron category due to dosimeter design or handling deficiencies. The participating dosimetry systems were separated into three categories on their dose evaluation procedure for low-energy photons. These were film dosimeters, fixed-calibration thermoluminescent (TL) dosimeters, and variable-calibration TL dosimeters. The performance of the variable-calibration design was best while the film dosimeters performed considerably worse than either TL dosimeter design. Beta energy dependence studies confirmed a strong correlation between sensitive element thickness, shallow element filtration and low-energy beta response. Studies of neutron calibration conditions for each participant suggested a relationship between response and calibration facility design

  2. Emergency Department Telepsychiatry Service Model for a Rural Regional Health System: The First Steps.

    Science.gov (United States)

    Meyer, James D; McKean, Alastair J S; Blegen, Rebecca N; Demaerschalk, Bart M

    2018-05-09

    Emergency departments (EDs) have recognized an increasing number of patients presenting with mental health (MH) concerns. This trend imposes greater demands upon EDs already operating at capacity. Many ED providers do not feel they are optimally prepared to provide the necessary MH care. One consideration in response to this dilemma is to use advanced telemedicine technology for psychiatric consultation. We examined a rural- and community-based health system operating 21 EDs, none of which has direct access to psychiatric consultation. Dedicated beds to MH range from zero (in EDs with only 3 beds) to 6 (in an ED with 38 beds). We conducted a needs assessment of this health system. This included a survey of emergency room providers with a 67% response rate and site visits to directly observe patient flow and communication with ED staff. A visioning workshop provided input from ED staff. Data were also obtained, which reflected ED admissions for the year 2015. The data provide a summary of provider concerns, a summary of MH presentations and diagnosis, and age groupings. The data also provide a time when most MH concerns present to the ED. Based upon these results, a proposed model for delivering comprehensive regional emergency telepsychiatry and behavioral health services is proposed. Emergency telepsychiatry services may be a tenable solution for addressing the shortage of psychiatric consultation to EDs in light of increasing demand for MH treatment in the ED.

  3. Electronic nicotine delivery system (ENDS) battery-related burns presenting to US emergency departments, 2016.

    Science.gov (United States)

    Corey, Catherine G; Chang, Joanne T; Rostron, Brian L

    2018-03-05

    Currently, an estimated 7.9 million US adults use electronic nicotine delivery systems (ENDS). Although published reports have identified fires and explosions related to use of ENDS since 2009, these reports do not provide national estimates of burn injuries associated with ENDS batteries in the US. We analyzed nationally representative data provided in the National Electronic Injury Surveillance System (NEISS) to estimate the number of US emergency department (ED) visits for burn injuries associated with ENDS batteries. We reviewed the case narrative field to gain additional insights into the circumstances of the burn injury. In 2016, 26 ENDS battery-related burn cases were captured by NEISS, which translates to a national estimate of 1007 (95%CI: 357-1657) injuries presenting in US EDs. Most of the burns were thermal burns (80.4%) and occurred to the upper leg/lower trunk (77.3%). Examination of the case narrative field indicated that at least 20 of the burn injuries occurred while ENDS batteries were in the user's pocket. Our study provides valuable information for understanding the current burden of ENDS battery-related burn injuries treated in US EDs. The nature and circumstances of the injuries suggest these incidents were unintentional and would potentially be prevented through battery design requirements, battery testing standards and public education related to ENDS battery safety.

  4. Design of the CART data system for the US Department of Energy's ARM Program

    International Nuclear Information System (INIS)

    Melton, R.B.; Campbell, A.P.; Edwards, D.M.; Kanciruk, P.; Tichler, J.L.

    1991-01-01

    The Department of Energy (DOE) has initiated a major atmospheric research effort to reduce the uncertainties found in general circulation and other models due to the effects of clouds and radiation. The objective of the Atmospheric Radiation Measurement Program (ARM) is to provide an experimental testbed for the study of important atmospheric effects, particularly cloud and radiative processes, and testing parameterizations of the processes for use in atmospheric models. This experimental testbed, known as the Clouds and Radiation Testbed (CART), will include a complex data system, the CART Data Environment (CDE). The major functions of the CDE will be to: acquire environments from instruments and external data sources; perform quality assessments of the data streams; create data streams of known quality to be used as model input compared to model output; execute the models and capture their predictions; and make data streams associated with model tests available to ARM investigators in near real-time. The CDE will also be expected to capture ancillary information (''meta-data'') associated with the data streams, provide data management facilities for design of ARM experiments, and provide for archival data storage. The first section of this paper presents background information on CART. Next the process for the functional design of the system is described, the functional requirements summarized, and the conceptual architecture of the CDE is presented. Finally, the status of the CDE design activities is summarized, and major technical challenges are discussed

  5. Internet-based reporting system for the US Department of Energy extended network of analytical laboratories

    International Nuclear Information System (INIS)

    Hembree, D.M. Jr.; Hanzelka, C.C.; Rose, L.J.; Price, A.; Holdren, G.R.

    1999-01-01

    The official implementation of environmental sampling under Programme 93+2 as a means to enhance nuclear safeguards for the International Atomic Energy Agency (IAEA) has led the U.S. Department of Energy (DOE) Extended Network of Analytical Laboratories (ENWAL) to reevaluate the effectiveness and efficiency of its support program in this area. One area of particular concern deals with the methods used for information transfer between the various DOE laboratories, the DOE coordination center in Oak Ridge, and IAEA headquarters in Vienna. This reevaluation has also been extended to included the type and structure of the database used to manage environmental sampling data generated within the DOE ENWAL. Efforts are currently underway to migrate to the same database used by the IAEA to manage environmental sampling data, and to develop a new database structure that allows easier use by the IAEA. The most important part of this upgrade program is the move to the internet to allow secure worldwide, dynamic access by all authorized users of the DOE system. As currently envisioned, a secure web browser and appropriate access privileges are all that will required to use the DOE data reporting and communication system. All transactions involving IAEA environmental samples, such as analysis requests, shipping notification, status information, and data reporting will be conducted over the internet under dynamic conditions. (author)

  6. Regulation of Neurotransmitter Responses in the Central Nervous System.

    Science.gov (United States)

    1987-05-01

    and identify by block number) FIELD GROUP SUB-GROUP J’-aminobutyric acid; yclic AM’P; neuromodulation ; brain 1ABTAT(Continue on reverse if necessary and...crucial enzyme for regulating neuromodulation in brain. Given the ultimate goal of developing novel pharmacological agents for N! manipulating...central nervous system function, the discovery of a biochemical response to a neuromodulator can be considered a major step in that direction. Thus, up to

  7. Unmanned aircraft systems (UAS) activities at the Department of the Interior

    Science.gov (United States)

    Quirk, Bruce K.; Hutt, Michael E.

    2014-01-01

    The U.S. Department of the Interior (DOI) is responsible for protecting and managing the natural resources and heritage on almost 20% of the land in the United States. The DOI’s mission requires access to remotely sensed data over vast lands, including areas that are remote and potentially dangerous to access. Unmanned Aircraft Systems (UAS) technology has the potential to enable the DOI to be a better steward of the land by: (1) Improving natural hazard forecasting and the analysis of the impacts. (2) Improving the understanding of climate change to better plan for likely impacts. (3) Developing precipitation and evaporation forecasting to better manage water resources. (4) Monitoring Arctic ice change and its impacts on ecosystems, coasts, and transportation. (5) Increasing safety and effectiveness of wildland fire management. (6) Enhancing search and rescue capabilities. (7) Broadening the abilities to monitor environmental or landscape conditions and changes. (8) Better understanding and protecting the Nation’s ecosystems. The initial operational testing and evaluations performed by the DOI have proven that UAS technology can be used to support many of the Department’s activities. UAS technology provides scientists a way to look longer, closer and more frequently at some of Earth’s most remote areas—places that were previously too dangerous or expensive to monitor in detail. The flexibility of operations and relative low cost to purchase and operate Small Unmanned Aerial System (sUAS) enhances the ability to track long-term landscape and environmental change. The initial testing indicates the operational costs are approximately 10% of traditional manned aircraft. In addition, users can quickly assess landscape-altering events such as wildland fires, floods and volcanoes. UAS technology will allow the DOI to do more with less and in the process enhance the Department’s ability to provide unbiased scientific information to help stakeholders make

  8. Regulation and Roles of Urocortins in the Vascular System

    Directory of Open Access Journals (Sweden)

    Kazunori Kageyama

    2012-01-01

    Full Text Available Urocortins (Ucns are members of the corticotropin-releasing factor (CRF family of peptides. Ucns would have potent effects on the cardiovascular system via the CRF receptor type 2 (CRF2 receptor. Regulation and roles of each Ucn have been determined in the vascular system. Ucns have more potent vasodilatory effects than CRF. Human umbilical vein endothelial cells (HUVECs express Ucns1-3 mRNAs, and the receptor, CRF2a receptor mRNA. Ucns1-3 mRNA levels are differentially regulated in HUVECs. Differential regulation of Ucns may suggest differential roles of those in HUVECs. Ucn1 and Ucn2 have strong effects on interleukin (IL-6 gene expression and secretion in rat aortic smooth muscle A7r5 cells. The increase that we observed in IL-6 levels following Ucn treatment of A7r5 cells suggests that smooth muscle cells may be a source of IL-6 secretion under physiological stress conditions. Ucns are important and unique modulators of vascular smooth muscle cells and act directly or indirectly as autocrine and paracrine factors in the vascular system.

  9. Regulation of bacterial virulence by Csr (Rsm) systems.

    Science.gov (United States)

    Vakulskas, Christopher A; Potts, Anastasia H; Babitzke, Paul; Ahmer, Brian M M; Romeo, Tony

    2015-06-01

    Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  10. Predicting Ambulance Time of Arrival to the Emergency Department Using Global Positioning System and Google Maps

    Science.gov (United States)

    Fleischman, Ross J.; Lundquist, Mark; Jui, Jonathan; Newgard, Craig D.; Warden, Craig

    2014-01-01

    Objective To derive and validate a model that accurately predicts ambulance arrival time that could be implemented as a Google Maps web application. Methods This was a retrospective study of all scene transports in Multnomah County, Oregon, from January 1 through December 31, 2008. Scene and destination hospital addresses were converted to coordinates. ArcGIS Network Analyst was used to estimate transport times based on street network speed limits. We then created a linear regression model to improve the accuracy of these street network estimates using weather, patient characteristics, use of lights and sirens, daylight, and rush-hour intervals. The model was derived from a 50% sample and validated on the remainder. Significance of the covariates was determined by p times recorded by computer-aided dispatch. We then built a Google Maps-based web application to demonstrate application in real-world EMS operations. Results There were 48,308 included transports. Street network estimates of transport time were accurate within 5 minutes of actual transport time less than 16% of the time. Actual transport times were longer during daylight and rush-hour intervals and shorter with use of lights and sirens. Age under 18 years, gender, wet weather, and trauma system entry were not significant predictors of transport time. Our model predicted arrival time within 5 minutes 73% of the time. For lights and sirens transports, accuracy was within 5 minutes 77% of the time. Accuracy was identical in the validation dataset. Lights and sirens saved an average of 3.1 minutes for transports under 8.8 minutes, and 5.3 minutes for longer transports. Conclusions An estimate of transport time based only on a street network significantly underestimated transport times. A simple model incorporating few variables can predict ambulance time of arrival to the emergency department with good accuracy. This model could be linked to global positioning system data and an automated Google Maps web

  11. Applying Systems Engineering Reduces Radiology Transport Cycle Times in the Emergency Department

    Science.gov (United States)

    White, Benjamin A.; Yun, Brian J.; Lev, Michael H.; Raja, Ali S.

    2017-01-01

    Introduction Emergency department (ED) crowding is widespread, and can result in care delays, medical errors, increased costs, and decreased patient satisfaction. Simultaneously, while capacity constraints on EDs are worsening, contributing factors such as patient volume and inpatient bed capacity are often outside the influence of ED administrators. Therefore, systems engineering approaches that improve throughput and reduce waste may hold the most readily available gains. Decreasing radiology turnaround times improves ED patient throughput and decreases patient waiting time. We sought to investigate the impact of systems engineering science targeting ED radiology transport delays and determine the most effective techniques. Methods This prospective, before-and-after analysis of radiology process flow improvements in an academic hospital ED was exempt from institutional review board review as a quality improvement initiative. We hypothesized that reorganization of radiology transport would improve radiology cycle time and reduce waste. The intervention included systems engineering science-based reorganization of ED radiology transport processes, largely using Lean methodologies, and adding no resources. The primary outcome was average transport time between study order and complete time. All patients presenting between 8/2013–3/2016 and requiring plain film imaging were included. We analyzed electronic medical record data using Microsoft Excel and SAS version 9.4, and we used a two-sample t-test to compare data from the pre- and post-intervention periods. Results Following the intervention, average transport time decreased significantly and sustainably. Average radiology transport time was 28.7 ± 4.2 minutes during the three months pre-intervention. It was reduced by 15% in the first three months (4.4 minutes [95% confidence interval [CI] 1.5–7.3]; to 24.3 ± 3.3 min, P=0.021), 19% in the following six months (5.4 minutes, 95% CI [2.7–8.2]; to 23.3 ± 3

  12. What Health-Related Functions Are Regulated by the Nervous System?

    Science.gov (United States)

    ... What health-related functions are regulated by the nervous system? The nervous system plays a role in nearly every aspect of ... feeling emotions. Functions that are regulated by the nervous system include (but are not limited to): Brain growth ...

  13. The Integrated Safety Management System (ISMS) of the US Department of Energy

    International Nuclear Information System (INIS)

    Linn, M.A.

    1999-01-01

    While the Integrated Safety Management System (ISMS) program is a fairly rational approach to safety, it represents the culmination of several years of hard-earned lessons learned. Considering the size and the diversity of interrelated elements which make up the USDOE complex, this result shows the determination of both the USDOE and its contractors to bring safety hazards to heel. While these lessons learned were frustrating and expensive, the results were several key insights upon which the ISMS was built: (1) Ensure safety management is integral to the business. Safety management must become part of each work activity, rather that something in addition to or on top of. (2) Tailor the safety requirements to the work and its hazards. In order to be cost-effective and efficient, safety management should have flexibility in order to match safety requirements with the level of the hazards in a graded manner. (3) Safety management must be coherent and integrated. Large and complex organizations are no excuse for fragmented and overlapping safety initiatives and programs. Simple, from the ground up objectives and principles must be defined and used to guide a comprehensive safety management program. (4) A safety management system must balance resources and priorities. The system must provide the means to balance resources against the particular work hazards, recognizing that different degrees of hazards requires corresponding prevention measures. (5) Clear roles and responsibilities for safety management must be defined. Both the regulator and the contractor have specific responsibilities for safety which must be clearly articulated at all levels of the work processes. (6) Those responsible for safety must have the competence to carry it out. Those assigned responsibilities must have the experience, knowledge, skills, and authority to carry them out. As one can surmise, the ISMS is not a new program to be implemented, but rather a new attitude which must be adopted

  14. H.R. 2662: This Act may be cited as the Department of Energy Nuclear Contractors Accountability and Award System Act of 1989. Introduced in the House of Representatives, One Hundredth First Congress, First Session, June 15, 1989

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    H.R. 2662 is a bill to prohibit the Department of Energy from paying fines or penalties assessed against national security program contractors for violation of laws or regulations and to direct the Secretary of Energy to revise the system of award fees to such contractors to encourage discovery and remedy of conditions and practices that could lead to such violations

  15. Department of Energy standard for the performance testing of personnel dosimetry systems

    International Nuclear Information System (INIS)

    1986-12-01

    This standard is intended to be used in the Department of Energy Laboratory Accreditation Program (DOELAP) for personnel dosimetry systems. It is based on the American National Standards Institute's (ANSI) ''Criteria for Testing Personnel Dosimetry Performance,'' ANSI N13.11-1983, recommendations made to DOE in ''Guidelines for the Calibration of Personnel Dosimeters,'' Pacific Northwest Laboratory (PNL)-4515 and comments received during peer review by DOE and DOE contractor personnel. The recommendations contained in PNL-4515 were based on an evaluation of ANSI N13.11 conducted for the Office of Nuclear Safety, DOE, by PNL. Parts of ANSI N13.11 that did not require modification were used essentially intact in this standard to maintain consistency with nationally recognized standards. Modifications to this standard have resulted from several DOE/DOE contractor reviews and a pilot testing session. An initial peer review by selected DOE and DOE contractor representatives on technical content was conducted in 1983. A review by DOE field offices, program offices, and contractors was conducted in mid-1984. A pilot performance testing session sponsored by the Office of Nuclear Safety was conducted in early 1985 by the Radiological and Environmental Sciences Laboratory, Idaho Falls. Results of the pilot test were reviewed in late 1985 by a DOE and DOE contractor committee. 11 refs., 4 tabs

  16. Department of Energy's Virtual Lab Infrastructure for Integrated Earth System Science Data

    Science.gov (United States)

    Williams, D. N.; Palanisamy, G.; Shipman, G.; Boden, T.; Voyles, J.

    2014-12-01

    The U.S. Department of Energy (DOE) Office of Biological and Environmental Research (BER) Climate and Environmental Sciences Division (CESD) produces a diversity of data, information, software, and model codes across its research and informatics programs and facilities. This information includes raw and reduced observational and instrumentation data, model codes, model-generated results, and integrated data products. Currently, most of this data and information are prepared and shared for program specific activities, corresponding to CESD organization research. A major challenge facing BER CESD is how best to inventory, integrate, and deliver these vast and diverse resources for the purpose of accelerating Earth system science research. This talk provides a concept for a CESD Integrated Data Ecosystem and an initial roadmap for its implementation to address this integration challenge in the "Big Data" domain. Towards this end, a new BER Virtual Laboratory Infrastructure will be presented, which will include services and software connecting the heterogeneous CESD data holdings, and constructed with open source software based on industry standards, protocols, and state-of-the-art technology.

  17. Emergency Department Visits Prior to Suicide and Homicide: Linking Statewide Surveillance Systems.

    Science.gov (United States)

    Cerel, Julie; Singleton, Michael D; Brown, Margaret M; Brown, Sabrina V; Bush, Heather M; Brancado, Candice J

    2016-01-01

    Emergency departments (EDs) serve a wide range of patients who present at risk of impending suicide and homicide. Two statewide surveillance systems were probabilistically linked to understand who utilizes EDs and then dies violently within 6 weeks. Each identified case was matched with four randomly selected controls on sex, race, date of birth, resident zip code, and date of ED visit vs. date of death. Matched-pair odds ratios were estimated by conditional logistic regression to assess differences between cases and controls on reported diagnoses and expected payment sources. Of 1,599 suicides and 569 homicides in the 3-year study period, 10.7% of decedents who died by suicide (mean = 13.6 days) and 8.3% who died by homicide (mean = 16.3 days) were seen in a state ED within 6 weeks prior to death. ED attendees who died by suicide were more likely to have a diagnosis of injury/ poisoning diagnosis or mental disorder and more likely to have Medicare. Those who died by homicide were more likely to have a diagnosis of injury/poisoning and less likely to have commercial insurance. It is essential for research to further explore risk factors for imminent suicide and homicide in ED patients who present for psychiatric conditions and general injuries.

  18. The United States Department of Energy (DOE) Computerized Accident/Incident Reporting System (CAIRS)

    International Nuclear Information System (INIS)

    Briscoe, G.J.

    1993-01-01

    The Department of Energy's (DOE) Computerized Accident/Incident Reporting System (CAIRS) is a comprehensive data base containing more than 50,000 investigation reports of injury/illness, property damage and vehicle accident cases representing safety data from 1975 to the present for more than 150 DOE contractor organizations. A special feature is that the text of each accident report is translated using a controlled dictionary and rigid sentence structure called Factor Relationship and Sequence of Events (FRASE) that enhances the ability to retrieve specific types of information and to perform detailed analyses. DOE summary and individual contractor reports are prepared quarterly and annually. In addition, ''Safety Performance Profile'' reports for individual organizations are prepared to provide advance information to appraisal teams, and special topical reports are prepared for areas of concern such as an increase in the number of security injuries or environmental releases. The data base is open to all DOE and Contractor registered users with no access restrictions other than that required by the Privacy Act

  19. Automating the Technical Library at Los Angeles' Department of Information Systems.

    Science.gov (United States)

    Gillette, Robert

    1992-01-01

    Description of the automation of the technical library of the City of Los Angeles Department of Information Services provides background information on the department and its library; lists the automation project goals and objectives; and describes the two software programs--ObjectVision and Paradox Engine--used as applications development tools…

  20. A self-configuring control system for storage and computing departments at INFN-CNAF Tierl

    Science.gov (United States)

    Gregori, Daniele; Dal Pra, Stefano; Ricci, Pier Paolo; Pezzi, Michele; Prosperini, Andrea; Sapunenko, Vladimir

    2015-05-01

    The storage and farming departments at the INFN-CNAF Tier1[1] manage approximately thousands of computing nodes and several hundreds of servers that provides access to the disk and tape storage. In particular, the storage server machines should provide the following services: an efficient access to about 15 petabytes of disk space with different cluster of GPFS file system, the data transfers between LHC Tiers sites (Tier0, Tier1 and Tier2) via GridFTP cluster and Xrootd protocol and finally the writing and reading data operations on magnetic tape backend. One of the most important and essential point in order to get a reliable service is a control system that can warn if problems arise and which is able to perform automatic recovery operations in case of service interruptions or major failures. Moreover, during daily operations the configurations can change, i.e. if the GPFS cluster nodes roles can be modified and therefore the obsolete nodes must be removed from the control system production, and the new servers should be added to the ones that are already present. The manual management of all these changes is an operation that can be somewhat difficult in case of several changes, it can also take a long time and is easily subject to human error or misconfiguration. For these reasons we have developed a control system with the feature of self-configure itself if any change occurs. Currently, this system has been in production for about a year at the INFN-CNAF Tier1 with good results and hardly any major drawback. There are three major key points in this system. The first is a software configurator service (e.g. Quattor or Puppet) for the servers machines that we want to monitor with the control system; this service must ensure the presence of appropriate sensors and custom scripts on the nodes to check and should be able to install and update software packages on them. The second key element is a database containing information, according to a suitable format, on

  1. A self-configuring control system for storage and computing departments at INFN-CNAF Tierl

    International Nuclear Information System (INIS)

    Gregori, Daniele; Dal Pra, Stefano; Ricci, Pier Paolo; Pezzi, Michele; Prosperini, Andrea; Sapunenko, Vladimir

    2015-01-01

    The storage and farming departments at the INFN-CNAF Tier1[1] manage approximately thousands of computing nodes and several hundreds of servers that provides access to the disk and tape storage. In particular, the storage server machines should provide the following services: an efficient access to about 15 petabytes of disk space with different cluster of GPFS file system, the data transfers between LHC Tiers sites (Tier0, Tier1 and Tier2) via GridFTP cluster and Xrootd protocol and finally the writing and reading data operations on magnetic tape backend. One of the most important and essential point in order to get a reliable service is a control system that can warn if problems arise and which is able to perform automatic recovery operations in case of service interruptions or major failures. Moreover, during daily operations the configurations can change, i.e. if the GPFS cluster nodes roles can be modified and therefore the obsolete nodes must be removed from the control system production, and the new servers should be added to the ones that are already present. The manual management of all these changes is an operation that can be somewhat difficult in case of several changes, it can also take a long time and is easily subject to human error or misconfiguration. For these reasons we have developed a control system with the feature of self-configure itself if any change occurs. Currently, this system has been in production for about a year at the INFN-CNAF Tier1 with good results and hardly any major drawback. There are three major key points in this system. The first is a software configurator service (e.g. Quattor or Puppet) for the servers machines that we want to monitor with the control system; this service must ensure the presence of appropriate sensors and custom scripts on the nodes to check and should be able to install and update software packages on them. The second key element is a database containing information, according to a suitable format, on

  2. Evaluation of alternatives for a second-generation transportation system for Department of Energy transuranic waste

    International Nuclear Information System (INIS)

    1984-01-01

    Department of Energy (DOE) waste storage sites will ship their contact-handled (CH) and remote-handled (RH) transuranic (TRU) waste to the Waste Isolation Pilot Plant (WIPP) beginning FY 1989. The CH-TRU waste will be shipped in the Transuranic Package Transported (TRUPACT-I), a new packaging being developed by Sandia National Laboratories, Albuquerque/Transportation Technology Center. Some of the DOE TRU waste, however, might be unsuitable for shipment in TRUPACT-I, and is designated special-shipped (SS) TRU waste. The purposes of this study were to: (1) identify the quantity and characteristics of SS-TRU waste stored and generated at DOE facilities; (2) identify alternatives for managing the SS-TRU waste; and (3) make overall recommendations for managing the SS-TRU waste. Data on quantity and characteristics were gathered through coordinating visits to the sites and extracting information from each site's records. Representatives of DOE organizations and contractors set objectives for managing the SS-TRU waste. Alternative shipping systems were then identified for CH SS-TRU waste and RH SS-TRU waste. Evaluations of these alternatives considered how well they would satisfy each objective, and associated potential problems. The study recommends delaying the decision on how best to transport the CH SS-TRU waste to WIPP until the amount of SS-TRU processed waste in heavy drums is known. These conditions and choices are presented: a relatively small number of processed, heavy drums could be shipped most economically via TRUPACT-I, mixed with lighter drums of unprocessed waste. If a large number of heavy drums is to be shipped, a shorter and narrower version of TRUPACT-I would be preferred alternative. The Defense High-Level Waste cask is the recommended alternative system for shipping RH SS-TRU waste. 12 references, 15 figures, 22 tables

  3. Deriving a Framework for a Systems Approach to Agitated Patient Care in the Emergency Department.

    Science.gov (United States)

    Wong, Ambrose H; Ruppel, Halley; Crispino, Lauren J; Rosenberg, Alana; Iennaco, Joanne D; Vaca, Federico E

    2018-05-01

    The rising agitated patient population presenting to the emergency department (ED) has caused increasing safety threats for health care workers and patients. Development of evidence-based strategies has been limited by the lack of a structured framework to examine agitated patient care in the ED. In this study, a systems approach from the patient safety literature was used to derive a comprehensive theoretical framework for addressing ED patient agitation. A mixed-methods approach was used with ED staff members at an academic site and a community site of a regional health care network. Participants consisted of resident and attending physicians, physician assistants/nurse practitioners, nurses, technicians, and security officers. After a simulated agitated patient encounter to prime participants, uniprofessional and interprofessional focus groups were conducted, followed by a structured thematic analysis using a grounded theory approach. Quantitative data consisted of surveys of violence exposure and attitudes toward patient aggression and management. Data saturation was reached with 57 participants. Violence exposure was higher for technicians, nurses, and officers. Conflicting priorities and management challenges occurred due to four main interconnected elements: perceived complex patient motivations; a patient care paradox between professional duty and personal safety; discordant interprofessional dynamics mitigated by respect and trust; and logistical challenges impeding care delivery and long-term outcomes. Using a systems approach, five interconnected levels of ED agitated patient care delivery were identified: patient, staff, team, ED microsystem, and health care macrosystem. These care dimensions were synthesized to form a novel patient safety-based framework that can help guide future research, practice, and policy. Copyright © 2018 The Joint Commission. Published by Elsevier Inc. All rights reserved.

  4. Role of the Ubiquitin Proteasome System in Regulating Skin Pigmentation

    Directory of Open Access Journals (Sweden)

    Hideya Ando

    2009-10-01

    Full Text Available Pigmentation of the skin, hair and eyes is regulated by tyrosinase, the critical rate-limiting enzyme in melanin synthesis by melanocytes. Tyrosinase is degraded endogenously, at least in part, by the ubiquitin proteasome system (UPS. Several types of inherited hypopigmentary diseases, such as oculocutaneous albinism and Hermansky-Pudlak syndrome, involve the aberrant processing and/or trafficking of tyrosinase and its subsequent degradation which can occur due to the quality-control machinery. Studies on carbohydrate modifications have revealed that tyrosinase in the endoplasmic reticulum (ER is proteolyzed via ER-associated protein degradation and that tyrosinase degradation can also occur following its complete maturation in the Golgi. Among intrinsic factors that regulate the UPS, fatty acids have been shown to modulate tyrosinase degradation in contrasting manners through increased or decreased amounts of ubiquitinated tyrosinase that leads to its accelerated or decelerated degradation by proteasomes.

  5. Yersinia Type III Secretion System Master Regulator LcrF

    Science.gov (United States)

    Schwiesow, Leah; Lam, Hanh

    2015-01-01

    Many Gram-negative pathogens express a type III secretion (T3SS) system to enable growth and survival within a host. The three human-pathogenic Yersinia species, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica, encode the Ysc T3SS, whose expression is controlled by an AraC-like master regulator called LcrF. In this review, we discuss LcrF structure and function as well as the environmental cues and pathways known to regulate LcrF expression. Similarities and differences in binding motifs and modes of action between LcrF and the Pseudomonas aeruginosa homolog ExsA are summarized. In addition, we present a new bioinformatics analysis that identifies putative LcrF binding sites within Yersinia target gene promoters. PMID:26644429

  6. Dynamics Analysis for Hydroturbine Regulating System Based on Matrix Model

    Directory of Open Access Journals (Sweden)

    Jiafu Wei

    2017-01-01

    Full Text Available The hydraulic turbine model is the key factor which affects the analysis precision of the hydraulic turbine governing system. This paper discusses the basic principle of the hydraulic turbine matrix model and gives two methods to realize. Using the characteristic matrix to describe unit flow and torque and their relationship with the opening and unit speed, it can accurately represent the nonlinear characteristics of the turbine, effectively improve the convergence of simulation process, and meet the needs of high precision real-time simulation of power system. Through the simulation of a number of power stations, it indicates that, by analyzing the dynamic process of the hydraulic turbine regulating with 5-order matrix model, the calculation results and field test data will have good consistency, and it can better meet the needs of power system dynamic simulation.

  7. Developing strategic systems supporting communities of practice in the Georgia Department of Transportation.

    Science.gov (United States)

    2011-12-01

    This study is designed to explore strategies through which the Georgia Department of : Transportation (GDOT) can develop communities of practice to help employees facilitate critical : exchanges of knowledge, support organizational learning, and ulti...

  8. Implementation of an Emergency Department Sepsis Bundle and System Redesign: A Process Improvement Initiative.

    Science.gov (United States)

    McColl, Tamara; Gatien, Mathieu; Calder, Lisa; Yadav, Krishan; Tam, Ryan; Ong, Melody; Taljaard, Monica; Stiell, Ian

    2017-03-01

    In 2008-2009, the Canadian Institute for Health Information reported over 30,000 cases of sepsis hospitalizations in Canada, an increase of almost 4,000 from 2005. Mortality rates from severe sepsis and septic shock continue to remain greater than 30% in Canada and are significantly higher than other critical conditions treated in the emergency department (ED). Our group formed a multidisciplinary sepsis committee, conducted an ED process of care analysis, and developed a quality improvement protocol. The objective of this study was to evaluate the effects of this sepsis management bundle on patient mortality. This before and after study was conducted in two large Canadian tertiary care EDs and included adult patients with suspected severe infection that met at least two systemic inflammatory response syndrome (SIRS) criteria. We studied the implementation of a sepsis bundle including triage flagging, RN medical directive, education campaign, and a modified sepsis protocol. The primary outcomes were 30-day all-cause mortality and sepsis protocol use. We included a total of 167 and 185 patients in the pre- and post-intervention analysis, respectively. Compared to the pre-intervention group, mortality was significantly lower in the post-intervention group (30.7% versus 17.3%; absolute difference, 13.4%; 95% CI 9.8-17.0; p=0.006). There was also a higher rate of sepsis protocol use in the post-intervention group (20.3% versus 80.5%, absolute difference 60.2%; 95% CI 55.1-65.3; pimproved early identification and protocolized medical care, was associated with improved time to achieve key therapeutic interventions and a reduction in 30-day mortality. Similar low-cost initiatives could be implemented in other EDs to potentially improve outcomes for this high-risk group of patients.

  9. The United States Department of Energy Office of Industrial Technology`s Technology Benefits Recording System

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, K.R.; Moore, N.L.

    1994-09-01

    The U.S. Department of Energy (DOE) Office of Industrial Technology`s (OIT`s) Technology Benefits Recording System (TBRS) was developed by Pacific Northwest Laboratory (PNL). The TBRS is used to organize and maintain records of the benefits accrued from the use of technologies developed with the assistance of OIT. OIT has had a sustained emphasis on technology deployment. While individual program managers have specific technology deployment goals for each of their ongoing programs, the Office has also established a separate Technology Deployment Division whose mission is to assist program managers and research and development partners commercialize technologies. As part of this effort, the Technology Deployment Division developed an energy-tracking task which has been performed by PNL since 1977. The goal of the energy-tracking task is to accurately assess the energy savings impact of OIT-developed technologies. In previous years, information on OIT-sponsored technologies existed in a variety of forms--first as a hardcopy, then electronically in several spreadsheet formats that existed in multiple software programs. The TBRS was created in 1993 for OIT and was based on information collected in all previous years from numerous industrial contacts, vendors, and plants that have installed OIT-sponsored technologies. The TBRS contains information on technologies commercialized between 1977 and the present, as well as information on emerging technologies in the late development/early commercialization stage of the technology life cycle. For each technology, details on the number of units sold and the energy saved are available on a year-by-year basis. Information regarding environmental benefits, productivity and competitiveness benefits, or impact that the technology may have had on employment is also available.

  10. Clinical governance implementation in a selected teaching emergency department: a systems approach

    Science.gov (United States)

    2012-01-01

    Background Clinical governance (CG) is among the different frameworks proposed to improve the quality of healthcare. Iran, like many other countries, has put healthcare quality improvement in its top health policy priorities. In November 2009, implementation of CG became a task for all hospitals across the country. However, it has been a challenge to clarify the notion of CG and the way to implement it in Iran. The purpose of this action research study is to understand how CG can be defined and implemented in a selected teaching emergency department (ED). Methods/design We will use Soft Systems Methodology for both designing the study and inquiring into its content. As we considered a complex problem situation regarding the quality of care in the selected ED, we initially conceptualized CG as a cyclic set of purposeful activities designed to explore the situation and find relevant changes to improve the quality of care. Then, implementation of CG will conceptually be to carry out that set of purposeful activities. The activities will be about: understanding the situation and finding out relevant issues concerning the quality of care; exploring different stakeholders’ views and ideas about the situation and how it can be improved; and defining actions to improve the quality of care through structured debates and development of accommodations among stakeholders. We will flexibly use qualitative methods of data collection and analysis in the course of the study. To ensure the study rigor, we will use different strategies. Discussion Successful implementation of CG, like other quality improvement frameworks, requires special consideration of underlying complexities. We believe that addressing the complex situation and reflections on involvement in this action research will make it possible to understand the concept of CG and its implementation in the selected setting. By describing the context and executed flexible methods of implementation, the results of this study

  11. The international regulation of Informal Value Transfer Systems

    Directory of Open Access Journals (Sweden)

    Anand Ajay Shah

    2007-12-01

    Full Text Available After the 11th September 2001 attacks on the United States international attention quickly focused on the sources and methods of terrorist financing. Among the methods terrorists and other criminal actors use to transfer funds are Informal Value Transfer Systems (IVTS which operate either outside the formal financial sector, or through use of the formal financial sector, but without leaving a full record of the transaction. Though the vast majority of funds moved through IVTS are the earnings of migrant workers and immigrant communities, the lack of uniform worldwide regulation of IVTS provides ample opportunity for abuse and misuse. The international community primarily responded to IVTS concerns through the Financial Action Task Force on Money Laundering, which issued a series of recommendations and best practices for states in regulating IVTS operations. While these recommendations are a secure beginning to regulation of IVTS operating within ethnic communities, they fail to address the more modern forms of IVTS that have come about in the post-Cold War globalised world. Comprehensive recommendations governing all types of IVTS, as well as concerted international cooperation and coordination are necessary to address this global phenomenon.

  12. Central nervous system regulation of intestinal lipid and lipoprotein metabolism.

    Science.gov (United States)

    Farr, Sarah; Taher, Jennifer; Adeli, Khosrow

    2016-02-01

    In response to nutrient availability, the small intestine and brain closely communicate to modulate energy homeostasis and metabolism. The gut-brain axis involves complex nutrient sensing mechanisms and an integration of neuronal and hormonal signaling. This review summarizes recent evidence implicating the gut-brain axis in regulating lipoprotein metabolism, with potential implications for the dyslipidemia of insulin resistant states. The intestine and brain possess distinct mechanisms for sensing lipid availability, which triggers subsequent regulation of feeding, glucose homeostasis, and adipose tissue metabolism. More recently, central receptors, neuropeptides, and gut hormones that communicate with the brain have been shown to modulate hepatic and intestinal lipoprotein metabolism via parasympathetic and sympathetic signaling. Gut-derived glucagon-like peptides appear to be particularly important in modulating the intestinal secretion of chylomicron particles via a novel brain-gut axis. Dysregulation of these pathways may contribute to postprandial diabetic dyslipidemia. Emerging evidence implicates the central and enteric nervous systems in controlling many aspects of lipid and lipoprotein metabolism. Bidirectional communication between the gut and brain involving neuronal pathways and gut peptides is critical for regulating feeding and metabolism, and forms a neuroendocrine circuit to modulate dietary fat absorption and intestinal production of atherogenic chylomicron particles.

  13. THE PROGRAMED CELL DEATH REGULATORS OF ISOLATED MODEL SYSTEMS

    Directory of Open Access Journals (Sweden)

    D. V. Vatlitsov

    2016-06-01

    Full Text Available The technology evolution creates the prerequisites for the emergence of new informational concept and approaches to the formation of a fundamentally new principles of biological objects understanding. The aim was to study the activators of the programmed cell death in an isolated system model. Cell culture aging parameters were performed on flow cytometer. It had formed the theory that the changes in the concentrations of metal ions and increase their extracellular concentration had formed a negative gradient into the cells.regulation of cell death. It was shown that the metals ions concentrations.

  14. Capability to model reactor regulating system in RFSP

    Energy Technology Data Exchange (ETDEWEB)

    Chow, H C; Rouben, B; Younis, M H; Jenkins, D A [Atomic Energy of Canada Ltd., Mississauga, ON (Canada); Baudouin, A [Hydro-Quebec, Montreal, PQ (Canada); Thompson, P D [New Brunswick Electric Power Commission, Point Lepreau, NB (Canada). Point Lepreau Generating Station

    1996-12-31

    The Reactor Regulating System package extracted from SMOKIN-G2 was linked within RFSP to the spatial kinetics calculation. The objective is to use this new capability in safety analysis to model the actions of RRS in hypothetical events such as in-core LOCA or moderator drain scenarios. This paper describes the RRS modelling in RFSP and its coupling to the neutronics calculations, verification of the RRS control routine functions, sample applications and comparisons to SMOKIN-G2 results for the same transient simulations. (author). 7 refs., 6 figs.

  15. Marshall Space Flight Center Propulsion Systems Department (PSD) Knowledge Management (KM) Initiative

    Science.gov (United States)

    Caraccioli, Paul; Varnedoe, Tom; Smith, Randy; McCarter, Mike; Wilson, Barry; Porter, Richard

    2006-01-01

    NASA Marshall Space Flight Center's Propulsion Systems Department (PSD) is four months into a fifteen month Knowledge Management (KM) initiative to support enhanced engineering decision making and analyses, faster resolution of anomalies (near-term) and effective, efficient knowledge infused engineering processes, reduced knowledge attrition, and reduced anomaly occurrences (long-term). The near-term objective of this initiative is developing a KM Pilot project, within the context of a 3-5 year KM strategy, to introduce and evaluate the use of KM within PSD. An internal NASA/MSFC PSD KM team was established early in project formulation to maintain a practitioner, user-centric focus throughout the conceptual development, planning and deployment of KM technologies and capabilities within the PSD. The PSD internal team is supported by the University of Alabama's Aging Infrastructure Systems Center of Excellence (AISCE), lntergraph Corporation, and The Knowledge Institute. The principle product of the initial four month effort has been strategic planning of PSD KNI implementation by first determining the "as is" state of KM capabilities and developing, planning and documenting the roadmap to achieve the desired "to be" state. Activities undertaken to suppoth e planning phase have included data gathering; cultural surveys, group work-sessions, interviews, documentation review, and independent research. Assessments and analyses have beon pedormed including industry benchmarking, related local and Agency initiatives, specific tools and techniques used and strategies for leveraging existing resources, people and technology to achieve common KM goals. Key findings captured in the PSD KM Strategic Plan include the system vision, purpose, stakeholders, prioritized strategic objectives mapped to the top ten practitioner needs and analysis of current resource usage. Opportunities identified from research, analyses, cultural1KM surveys and practitioner interviews include

  16. Optimal Scheduling of an Regional Integrated Energy System with Energy Storage Systems for Service Regulation

    Directory of Open Access Journals (Sweden)

    Hengrui Ma

    2018-01-01

    Full Text Available Ancillary services are critical to maintaining the safe and stable operation of power systems that contain a high penetration level of renewable energy resources. As a high-quality regulation resource, the regional integrated energy system (RIES with energy storage system (ESS can effectively adjust the non-negligible frequency offset caused by the renewable energy integration into the power system, and help solve the problem of power system frequency stability. In this paper, the optimization model aiming at regional integrated energy system as a participant in the regulation market based on pay-for-performance is established. Meanwhile YALMIP + CPLEX is used to simulate and analyze the total operating cost under different dispatch modes. This paper uses the actual operation model of the PJM regulation market to guide the optimal allocation of regulation resource in the regional integrated energy system, and provides a balance between the power trading revenue and regulation market revenue in order to achieve the maximum profit.

  17. Factors Affecting Acceptance of Hospital Information Systems Based on Extended Technology Acceptance Model: A Case Study in Three Paraclinical Departments.

    Science.gov (United States)

    Nadri, Hamed; Rahimi, Bahlol; Lotfnezhad Afshar, Hadi; Samadbeik, Mahnaz; Garavand, Ali

    2018-04-01

     Regardless of the acceptance of users, information and communication systems can be considered as a health intervention designed to improve the care delivered to patients. This study aimed to determine the adoption and use of the extended Technology Acceptance Model (TAM2) by the users of hospital information system (HIS) in paraclinical departments including laboratory, radiology, and nutrition and to investigate the key factors of adoption and use of these systems.  A standard questionnaire was used to collect the data from nearly 253 users of these systems in paraclinical departments of eight university hospitals in two different cities of Iran. A total of 202 questionnaires including valid responses were used in this study (105 in Urmia and 97 in Khorramabad). The data were processed using LISREL and SPSS software and statistical analysis technique was based on the structural equation modeling (SEM).  It was found that the original TAM constructs had a significant impact on the staffs' behavioral intention to adopt HIS in paraclinical departments. The results of this study indicated that cognitive instrumental processes (job relevance, output quality, result demonstrability, and perceived ease of use), except for result demonstrability, were significant predictors of intention to use, whereas the result revealed no significant relationship between social influence processes (subjective norm, voluntariness, and image) and the users' behavioral intention to use the system.  The results confirmed that several factors in the TAM2 that were important in previous studies were not significant in paraclinical departments and in government-owned hospitals. The users' behavior factors are essential for successful usage of the system and should be considered. It provides valuable information for hospital system providers and policy makers in understanding the adoption challenges as well as practical guidance for the successful implementation of information

  18. The Proprioceptive System Regulates Morphologic Restoration of Fractured Bones

    Directory of Open Access Journals (Sweden)

    Ronen Blecher

    2017-08-01

    Full Text Available Successful fracture repair requires restoration of bone morphology and mechanical integrity. Recent evidence shows that fractured bones of neonatal mice undergo spontaneous realignment, dubbed “natural reduction.” Here, we show that natural reduction is regulated by the proprioceptive system and improves with age. Comparison among mice of different ages revealed, surprisingly, that 3-month-old mice exhibited more rapid and effective natural reduction than newborns. Fractured bones of null mutants for transcription factor Runx3, lacking functional proprioceptors, failed to realign properly. Blocking Runx3 expression in the peripheral nervous system, but not in limb mesenchyme, recapitulated the null phenotype, as did inactivation of muscles flanking the fracture site. Egr3 knockout mice, which lack muscle spindles but not Golgi tendon organs, displayed a less severe phenotype, suggesting that both receptor types, as well as muscle contraction, are required for this regulatory mechanism. These findings uncover a physiological role for proprioception in non-autonomous regulation of skeletal integrity.

  19. Organisational Learning and Systems of Labour Market Regulation in Europe

    DEFF Research Database (Denmark)

    Holm, Jacob Rubæk; Lorenz, Edward; Lundvall, Bengt-Åke

    This paper establishes a link between international differences in the organisation of work and modes of regulation of labour markets within Europe. The paper operates with four forms of work organisation (discretionary learning, lean production, Taylorism and simple or traditional). Through...... a factor analysis three dimensions of national labour market systems (flexible security, passive security and job support) are defined. Using a multilevel logistic regression model that takes into account both characteristics of individuals and of national labour market systems it is shown...... that there is a significant positive correlation between flexible security and the prevalence of discretionary learning. On this basis we point to an extension of flexible security in Europe’s labour markets as an adequate response to the current crisis....

  20. Past and future regulation to prevent a systemic financial crisis

    Directory of Open Access Journals (Sweden)

    Mario Sarcinelli

    2010-01-01

    Full Text Available The article is a revised and updated version of that published on the March 2010 issues of Moneta e Credito. It was there claimed that, up to now, the G20 has supervised the process to revitalize the real economy affected by the Great Recession through fiscal stimuli and a very easy monetary policy, and to rescue the battered financial system by injecting capital into giant banks and firms. The G20 is now turning its attention to financial regulation, with the FSB as its main operational arm. The ideas that are being proposed stress the need for disincentives toward too much risk taking (more capital, higher liquidity, limits to remunerations and bonuses, etc., particularly by big and complex financial institutions that are likely to entail systemic risks. The paper maintains that, as the disincentive approach is insufficient to deter financial managers looking for power, some kind of segmentation needs to be introduced, as suggested by Paul Volcker.

  1. SELF-REGULATED SHOCKS IN MASSIVE STAR BINARY SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Parkin, E. R.; Sim, S. A., E-mail: parkin@mso.anu.edu.au, E-mail: s.sim@qub.ac.uk [Research School of Astronomy and Astrophysics, Australian National University, ACT 2611 (Australia)

    2013-04-20

    In an early-type, massive star binary system, X-ray bright shocks result from the powerful collision of stellar winds driven by radiation pressure on spectral line transitions. We examine the influence of the X-rays from the wind-wind collision shocks on the radiative driving of the stellar winds using steady-state models that include a parameterized line force with X-ray ionization dependence. Our primary result is that X-ray radiation from the shocks inhibits wind acceleration and can lead to a lower pre-shock velocity, and a correspondingly lower shocked plasma temperature, yet the intrinsic X-ray luminosity of the shocks, L{sub X}, remains largely unaltered, with the exception of a modest increase at small binary separations. Due to the feedback loop between the ionizing X-rays from the shocks and the wind driving, we term this scenario as self-regulated shocks. This effect is found to greatly increase the range of binary separations at which a wind-photosphere collision is likely to occur in systems where the momenta of the two winds are significantly different. Furthermore, the excessive levels of X-ray ionization close to the shocks completely suppress the line force, and we suggest that this may render radiative braking less effective. Comparisons of model results against observations reveal reasonable agreement in terms of log (L{sub X}/L{sub bol}). The inclusion of self-regulated shocks improves the match for kT values in roughly equal wind momenta systems, but there is a systematic offset for systems with unequal wind momenta (if considered to be a wind-photosphere collision).

  2. SELF-REGULATED SHOCKS IN MASSIVE STAR BINARY SYSTEMS

    International Nuclear Information System (INIS)

    Parkin, E. R.; Sim, S. A.

    2013-01-01

    In an early-type, massive star binary system, X-ray bright shocks result from the powerful collision of stellar winds driven by radiation pressure on spectral line transitions. We examine the influence of the X-rays from the wind-wind collision shocks on the radiative driving of the stellar winds using steady-state models that include a parameterized line force with X-ray ionization dependence. Our primary result is that X-ray radiation from the shocks inhibits wind acceleration and can lead to a lower pre-shock velocity, and a correspondingly lower shocked plasma temperature, yet the intrinsic X-ray luminosity of the shocks, L X , remains largely unaltered, with the exception of a modest increase at small binary separations. Due to the feedback loop between the ionizing X-rays from the shocks and the wind driving, we term this scenario as self-regulated shocks. This effect is found to greatly increase the range of binary separations at which a wind-photosphere collision is likely to occur in systems where the momenta of the two winds are significantly different. Furthermore, the excessive levels of X-ray ionization close to the shocks completely suppress the line force, and we suggest that this may render radiative braking less effective. Comparisons of model results against observations reveal reasonable agreement in terms of log (L X /L bol ). The inclusion of self-regulated shocks improves the match for kT values in roughly equal wind momenta systems, but there is a systematic offset for systems with unequal wind momenta (if considered to be a wind-photosphere collision).

  3. Leadership and effective succession planning in health-system pharmacy departments.

    Science.gov (United States)

    Ellinger, Lara Kathryn; Trapskin, Philip J; Black, Raymond; Kotis, Despina; Alexander, Earnest

    2014-04-01

    Leadership succession planning is crucial to the continuity of the comprehensive vision of the hospital pharmacy department. Leadership development is arguably the main component of training and preparing pharmacists to assume managerial positions. Succession planning begins with a review of the organizational chart in the context of the institution's strategic plan. Then career ladders are developed and key positions that require succession plans are identified. Employee profiles and talent inventory should be performed for all employees to identify education, talent, and experience, as well as areas that need improvement. Employees should set objective goals that align with the department's strategic plan, and management should work collaboratively with employees on how to achieve their goals within a certain timeframe. The succession planning process is dynamic and evolving, and periodic assessments should be conducted to determine how improvements can be made. Succession planning can serve as a marker for the success of hospital pharmacy departments.

  4. Distributed Cooperative Regulation for Multiagent Systems and Its Applications to Power Systems: A Survey

    Science.gov (United States)

    Li, Yaping; Yong, Taiyou; Yu, Jie; Mao, Wenbo

    2014-01-01

    Cooperative regulation of multiagent systems has become an active research area in the past decade. This paper reviews some recent progress in distributed coordination control for leader-following multiagent systems and its applications in power system and mainly focuses on the cooperative tracking control in terms of consensus tracking control and containment tracking control. Next, methods on how to rank the network nodes are summarized for undirected/directed network, based on which one can determine which follower should be connected to leaders such that partial followers can perceive leaders' information. Furthermore, we present a survey of the most relevant scientific studies investigating the regulation and optimization problems in power systems based on distributed strategies. Finally, some potential applications in the frequency tracking regulation of smart grids are discussed at the end of the paper. PMID:25243199

  5. Distributed cooperative regulation for multiagent systems and its applications to power systems: a survey.

    Science.gov (United States)

    Hu, Jianqiang; Li, Yaping; Yong, Taiyou; Cao, Jinde; Yu, Jie; Mao, Wenbo

    2014-01-01

    Cooperative regulation of multiagent systems has become an active research area in the past decade. This paper reviews some recent progress in distributed coordination control for leader-following multiagent systems and its applications in power system and mainly focuses on the cooperative tracking control in terms of consensus tracking control and containment tracking control. Next, methods on how to rank the network nodes are summarized for undirected/directed network, based on which one can determine which follower should be connected to leaders such that partial followers can perceive leaders' information. Furthermore, we present a survey of the most relevant scientific studies investigating the regulation and optimization problems in power systems based on distributed strategies. Finally, some potential applications in the frequency tracking regulation of smart grids are discussed at the end of the paper.

  6. Geographic information system data from ambulances applied in the emergency department: effects on patient reception.

    Science.gov (United States)

    Raaber, Nikolaj; Duvald, Iben; Riddervold, Ingunn; Christensen, Erika F; Kirkegaard, Hans

    2016-03-31

    Emergency departments (ED) recognize crowding and handover from prehospital to in-hospital settings to be major challenges. Prehospital Geographical Information Systems (GIS) may be a promising tool to address such issues. In this study, the use of prehospital GIS data was implemented in an ED in order to investigate its effect on 1) wait time and unprepared activations of Trauma Teams (TT) and Medical Emergency Teams (MET) and 2) nurses' perceptions regarding patient reception, workflow and resource utilization. From May 1st 2014 to October 31th 2014, GIS data was displayed in the ED. Data included real-time estimated time of arrival, distance to ED, dispatch criteria, patient data and ambulance contact information. Data was used by coordinating nurses for time activation of TT and MET involved in the initial treatment of severely-injured or critically-ill patients. In addition, it was used as a logistics tool for handling all other patients transported by ambulance to the ED. The study followed a mixed-methods design, consisting of a quantitative study (before and after intervention) and a qualitative study (survey and interviews). Participants included all patients received by TT or MET and coordinating nurses in the ED. 1.) Quantitative: 599 patients were included. The median wait time for TT and MET was 5 min both before and after the GIS intervention, showing no difference (p = 0.18). A significant reduction in the subgroup of waits >10 min was found (p GIS data as a tool to optimize resource utilization and quality of all patients' reception, critically or non-critically ill. No substantial disadvantages were reported. The contradiction of measured median wait time and nurses perceived improved timing of team activation may result from having both RT- ETA and supplemental patient information not only for seriously-injured or critically-ill patients received by the TT and MET, but for all patients transported by ambulance. The reduction in waits > 10

  7. Clinical governance implementation in a selected teaching emergency department: a systems approach

    Directory of Open Access Journals (Sweden)

    Heyrani Ali

    2012-09-01

    Full Text Available Abstract Background Clinical governance (CG is among the different frameworks proposed to improve the quality of healthcare. Iran, like many other countries, has put healthcare quality improvement in its top health policy priorities. In November 2009, implementation of CG became a task for all hospitals across the country. However, it has been a challenge to clarify the notion of CG and the way to implement it in Iran. The purpose of this action research study is to understand how CG can be defined and implemented in a selected teaching emergency department (ED. Methods/design We will use Soft Systems Methodology for both designing the study and inquiring into its content. As we considered a complex problem situation regarding the quality of care in the selected ED, we initially conceptualized CG as a cyclic set of purposeful activities designed to explore the situation and find relevant changes to improve the quality of care. Then, implementation of CG will conceptually be to carry out that set of purposeful activities. The activities will be about: understanding the situation and finding out relevant issues concerning the quality of care; exploring different stakeholders’ views and ideas about the situation and how it can be improved; and defining actions to improve the quality of care through structured debates and development of accommodations among stakeholders. We will flexibly use qualitative methods of data collection and analysis in the course of the study. To ensure the study rigor, we will use different strategies. Discussion Successful implementation of CG, like other quality improvement frameworks, requires special consideration of underlying complexities. We believe that addressing the complex situation and reflections on involvement in this action research will make it possible to understand the concept of CG and its implementation in the selected setting. By describing the context and executed flexible methods of implementation

  8. New around-the-clock radiology coverage system for the emergency department: a satisfaction survey among clinicians

    International Nuclear Information System (INIS)

    Choi, Young Hun; Jae, Hwan Jun; Shin, Cheong Il; Song, Su Jin; Cha, Won Cheol; Na, Dong Gyu

    2008-01-01

    The purpose of this study was to assess the clinician satisfaction of a newly introduced around-the-clock radiology coverage system for the emergency department. Seventeen emergency physicians (8 board certified physicians, 9 residents) were invited to fill out a survey pertaining to the newly introduced radiology coverage system for the emergency department. The questionnaire included 10 questions covering three major topics. The first topic related to the around-the-clock radiology coverage by two full-time radiology residents. The second topic focused on the preliminary interpretations of radiology residents. The last topic included the interpretation assistance system by board-certified radiologists. The answers to each question were assessed using a scoring system of 1 to 5. The mean satisfaction score of the around-the-clock radiology coverage system by the two full-time radiology residents was 4.6 (range 3-5). The mean score for the preliminary interpretation system by the radiology residents was 4.8 (range 4-5). The score for the reliability of the preliminary versus the final interpretation was 4.1 (range 4-5). Lastly, the mean score for the interpretation assistance system by board-certified radiologists was 4.9 (range 4-5). The results of this study indicate a high satisfaction rating among clinicians' of the new around-the-clock radiology coverage system for the emergency department

  9. Incremental cost of department-wide implementation of a picture archiving and communication system and computed radiography.

    Science.gov (United States)

    Pratt, H M; Langlotz, C P; Feingold, E R; Schwartz, J S; Kundel, H L

    1998-01-01

    To determine the incremental cash flows associated with department-wide implementation of a picture archiving and communication system (PACS) and computed radiography (CR) at a large academic medical center. The authors determined all capital and operational costs associated with PACS implementation during an 8-year time horizon. Economic effects were identified, adjusted for time value, and used to calculate net present values (NPVs) for each section of the department of radiology and for the department as a whole. The chest-bone section used the most resources. Changes in cost assumptions for the chest-bone section had a dominant effect on the department-wide NPV. The base-case NPV (i.e., that determined by using the initial assumptions) was negative, indicating that additional net costs are incurred by the radiology department from PACS implementation. PACS and CR provide cost savings only when a 12-year hardware life span is assumed, when CR equipment is removed from the analysis, or when digitized long-term archives are compressed at a rate of 10:1. Full PACS-CR implementation would not provide cost savings for a large, subspecialized department. However, institutions that are committed to CR implementation (for whom CR implementation would represent a sunk cost) or institutions that are able to archive images by using image compression will experience cost savings from PACS.

  10. Management system for regulating transport of radioactive material

    International Nuclear Information System (INIS)

    Lopez Vietri, Jorge; Capadona, Nancy; Barenghi, Leonardo

    2008-01-01

    Full text: The objective of this paper is to describe the main characteristics and fundamentals of the Nuclear regulatory Authority's (Autoridad Regulatoria Nuclear, ARN) management system applied to the regulation of transport of radioactive material, in Argentina. In the frame of ARN's quality policy, 'Protection against ionizing radiation on transport of radioactive materials' was selected as one of the regulatory processes, named TRM process from now on. ARN's quality management system is integrally based on ISO 9000 system addressed to help organizations in designing and implementing their quality management systems. TRM process was split into five sub processes in order to facilitate the implementation of quality system. Such sub processes were defined taking account of the main functions developed by ARN in the branch of safe transport of radioactive materials and are listed below: 1) Development and updating of standards and regulatory guides; 2) Licensing of packages, special radioactive materials and consignments of radioactive materials; 3) Compliance assurance during the transport of radioactive materials, and 4) Training, advising and communications. For each of these sub processes were specified their objectives, inputs, activities and outputs, the clients and stakeholders, responsibilities, supporting documents, control of documents and records, control of non-conformances, monitoring and measurements, audits, feedback and improvement. It was decided to develop a quality plan to organize and manage activities to meet quality requirements, to optimize the use of limited resources of the organization and to be used as a basis for monitoring and assessing compliance with the requirements, both internal and external. Supporting documents for sub processes were issued, validated, reviewed and improved as an essential point to implement continuous improving. Simultaneously, some indexes were defined to monitor and measure the sub processes as a way to show

  11. Joint-Service Integration: An Organizational Culture Study of the United States Department of Defense Voluntary Education System

    Science.gov (United States)

    Benson, Martin K.

    2010-01-01

    The purpose of the descriptive case study with a multiple case framework was to (a) describe the organizational cultures of education programs and leaders in the United States (U.S.) Department of Defense (DoD) voluntary education system on Oahu, Hawaii; (b) determine if an overlapping common organizational culture exists; and (c) assess the…

  12. A history of wind erosion prediction models in the United States Department of Agriculture: The Wind Erosion Prediction System (WEPS)

    Science.gov (United States)

    Development of the Wind Erosion Prediction System (WEPS) was officially inaugurated in 1985 by United States Department of Agriculture-Agricultural Research Service (USDA-ARS) scientists in response to customer requests, particularly those coming from the USDA Soil Conservation Service (SCS), for im...

  13. Molecular mechanisms of aging and immune system regulation in Drosophila.

    Science.gov (United States)

    Eleftherianos, Ioannis; Castillo, Julio Cesar

    2012-01-01

    Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span.

  14. US Department of Energy National Solid Waste Information Management System (NSWIMS) annual report for calendar year 1988

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, T.

    1989-09-01

    This report is generated annually from the National Solid Waste Information Management System (SWIMS) database. The SWIMS database operates under NOMAD2, fourth generation database management system. The database resides on an IBM 3083 mainframe with a virtual machine operating system. This system was implemented to meet the requirements of Energy Research and Development Administration Manual. The SWIMS database has kept pace with requirements of subsequent directives and complies with current Department of Energy (DOE) orders for retention of data on the management of solid low-level radioactive waste (LLW). SWIMS provides a comprehensive method for collecting and maintaining data related to management of US DOE and Department of Defense (DOE/Defense) related LLW. 33 figs., 29 tabs.

  15. Regulation of Central Nervous System Myelination in Higher Brain Functions

    Directory of Open Access Journals (Sweden)

    Mara Nickel

    2018-01-01

    Full Text Available The hippocampus and the prefrontal cortex are interconnected brain regions, playing central roles in higher brain functions, including learning and memory, planning complex cognitive behavior, and moderating social behavior. The axons in these regions continue to be myelinated into adulthood in humans, which coincides with maturation of personality and decision-making. Myelin consists of dense layers of lipid membranes wrapping around the axons to provide electrical insulation and trophic support and can profoundly affect neural circuit computation. Recent studies have revealed that long-lasting changes of myelination can be induced in these brain regions by experience, such as social isolation, stress, and alcohol abuse, as well as by neurological and psychiatric abnormalities. However, the mechanism and function of these changes remain poorly understood. Myelin regulation represents a new form of neural plasticity. Some progress has been made to provide new mechanistic insights into activity-independent and activity-dependent regulations of myelination in different experimental systems. More extensive investigations are needed in this important but underexplored research field, in order to shed light on how higher brain functions and myelination interplay in the hippocampus and prefrontal cortex.

  16. Hyperthyroidism differentially regulates neuropeptide S system in the rat brain.

    Science.gov (United States)

    González, Carmen R; Martínez de Morentin, Pablo B; Martínez-Sánchez, Noelia; Gómez-Díaz, Consuelo; Lage, Ricardo; Varela, Luis; Diéguez, Carlos; Nogueiras, Rubén; Castaño, Justo P; López, Miguel

    2012-04-23

    Thyroid hormones play an important role in the regulation of energy balance, sleep and emotional behaviors. Neuropeptide S (NPS) is a recently discovered neuropeptide, regulating feeding, sleep and anxiety. Here, we examined the effect of hyperthyroidism on the gene and protein expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus, brainstem and amygdala of rats. Our results showed that the expression of NPS and NPS-R was differentially modulated by hyperthyroidism in the rat brain. NPS and NPS-R mRNA and protein levels were decreased in the hypothalamus of hyperthyroid rats. Conversely NPS-R expression was highly increased in the brainstem and NPS and NPS-R expression were unchanged in the amygdala of these rats. These data suggest that changes in anxiety and food intake patterns observed in hyperthyroidism could be associated with changes in the expression of NPS and NPS-R. Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Adaption of the Magnetometer Towed Array geophysical system to meet Department of Energy needs for hazardous waste site characterization

    International Nuclear Information System (INIS)

    Cochran, J.R.; McDonald, J.R.; Russell, R.J.; Robertson, R.; Hensel, E.

    1995-10-01

    This report documents US Department of Energy (DOE)-funded activities that have adapted the US Navy's Surface Towed Ordnance Locator System (STOLS) to meet DOE needs for a ''... better, faster, safer and cheaper ...'' system for characterizing inactive hazardous waste sites. These activities were undertaken by Sandia National Laboratories (Sandia), the Naval Research Laboratory, Geo-Centers Inc., New Mexico State University and others under the title of the Magnetometer Towed Array (MTA)

  18. Re-engineering software systems in the Department of Defense using integrated computer aided software engineering tools

    OpenAIRE

    Jennings, Charles A.

    1992-01-01

    Approved for public release; distribution is unlimited The Department of Defense (DoD) is plagues with severe cost overruns and delays in developing software systems. Existing software within Dod, some developed 15-to 20 years ago, require continual maintenance and modification. Major difficulties arise with maintaining older systems due to cryptic source code and a lack of adequate documentation. To remedy this situation, the DoD, is pursuing the integrated computer aided software engi...

  19. A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system.

    Science.gov (United States)

    Sudomoina, Marina; Latypova, Ekaterina; Favorova, Olga O; Golemis, Erica A; Serebriiskii, Ilya G

    2004-04-29

    Whether for cell culture studies of protein function, construction of mouse models to enable in vivo analysis of disease epidemiology, or ultimately gene therapy of human diseases, a critical enabling step is the ability to achieve finely controlled regulation of gene expression. Previous efforts to achieve this goal have explored inducible drug regulation of gene expression, and construction of synthetic promoters based on two-hybrid paradigms, among others. In this report, we describe the combination of dimerizer-regulated two-hybrid and tetracycline regulatory elements in an ordered cascade, placing expression of endpoint reporters under the control of two distinct drugs. In this Dual Drug Control (DDC) system, a first plasmid expresses fusion proteins to DBD and AD, which interact only in the presence of a small molecule dimerizer; a second plasmid encodes a cassette transcriptionally responsive to the first DBD, directing expression of the Tet-OFF protein; and a third plasmid encodes a reporter gene transcriptionally responsive to binding by Tet-OFF. We evaluate the dynamic range and specificity of this system in comparison to other available systems. This study demonstrates the feasibility of combining two discrete drug-regulated expression systems in a temporally sequential cascade, without loss of dynamic range of signal induction. The efficient layering of control levels allowed by this combination of elements provides the potential for the generation of complex control circuitry that may advance ability to regulate gene expression in vivo.

  20. A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC system

    Directory of Open Access Journals (Sweden)

    Golemis Erica A

    2004-04-01

    Full Text Available Abstract Background Whether for cell culture studies of protein function, construction of mouse models to enable in vivo analysis of disease epidemiology, or ultimately gene therapy of human diseases, a critical enabling step is the ability to achieve finely controlled regulation of gene expression. Previous efforts to achieve this goal have explored inducible drug regulation of gene expression, and construction of synthetic promoters based on two-hybrid paradigms, among others. Results In this report, we describe the combination of dimerizer-regulated two-hybrid and tetracycline regulatory elements in an ordered cascade, placing expression of endpoint reporters under the control of two distinct drugs. In this Dual Drug Control (DDC system, a first plasmid expresses fusion proteins to DBD and AD, which interact only in the presence of a small molecule dimerizer; a second plasmid encodes a cassette transcriptionally responsive to the first DBD, directing expression of the Tet-OFF protein; and a third plasmid encodes a reporter gene transcriptionally responsive to binding by Tet-OFF. We evaluate the dynamic range and specificity of this system in comparison to other available systems. Conclusion This study demonstrates the feasibility of combining two discrete drug-regulated expression systems in a temporally sequential cascade, without loss of dynamic range of signal induction. The efficient layering of control levels allowed by this combination of elements provides the potential for the generation of complex control circuitry that may advance ability to regulate gene expression in vivo.

  1. The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System.

    Science.gov (United States)

    Sun, Yongjun; Zhan, Liying; Cheng, Xiaokun; Zhang, Linan; Hu, Jie; Gao, Zibin

    2017-04-01

    The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain function, as the abnormal regulation of GluN2A may induce some neuropsychiatric disorders. This review will examine the regulation of GluN2A by endogenous and exogenous regulators in the central nervous system.

  2. Factors Influencing the Effectiveness of Systems Engineering Training and Education in the Department of Defense

    Science.gov (United States)

    2011-04-30

    learning. Recommendations are also presented for additional research into a more effective systems engineering andragogy . 15. SUBJECT TERMS 16...into a more effective systems engineering andragogy . Purpose Competency-based training for defense acquisition workers in the systems engineering

  3. Regulation of Body Temperature by the Nervous System.

    Science.gov (United States)

    Tan, Chan Lek; Knight, Zachary A

    2018-04-04

    The regulation of body temperature is one of the most critical functions of the nervous system. Here we review our current understanding of thermoregulation in mammals. We outline the molecules and cells that measure body temperature in the periphery, the neural pathways that communicate this information to the brain, and the central circuits that coordinate the homeostatic response. We also discuss some of the key unresolved issues in this field, including the following: the role of temperature sensing in the brain, the molecular identity of the warm sensor, the central representation of the labeled line for cold, and the neural substrates of thermoregulatory behavior. We suggest that approaches for molecularly defined circuit analysis will provide new insight into these topics in the near future. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. Algorithm of dynamic regulation of a system of duct, for a high accuracy climatic system

    Science.gov (United States)

    Arbatskiy, A. A.; Afonina, G. N.; Glazov, V. S.

    2017-11-01

    Currently, major part of climatic system, are stationary in projected mode only. At the same time, many modern industrial sites, require constant or periodical changes in technological process. That is 80% of the time, the industrial site is not require ventilation system in projected mode and high precision of climatic parameters must maintain. While that not constantly is in use for climatic systems, which use in parallel for different rooms, we will be have a problem for balance of duct system. For this problem, was created the algorithm for quantity regulation, with minimal changes. Dynamic duct system: Developed of parallel control system of air balance, with high precision of climatic parameters. The Algorithm provide a permanent pressure in main duct, in different a flow of air. Therefore, the ending devises air flow have only one parameter for regulation - flaps open area. Precision of regulation increase and the climatic system provide high precision for temperature and humidity (0,5C for temperature, 5% for relative humidity). Result: The research has been made in CFD-system - PHOENICS. Results for velocity of air in duct, for pressure of air in duct for different operation mode, has been obtained. Equation for air valves positions, with different parameters for climate in room’s, has been obtained. Energy saving potential for dynamic duct system, for different types of a rooms, has been calculated.

  5. Phosphoenolpyruvate phosphotransferase system components positively regulate Klebsiella biofilm formation

    Directory of Open Access Journals (Sweden)

    Yu-Tze Horng

    2018-04-01

    Full Text Available Background/Purpose: Klebsiella pneumoniae is one of the leading causes of device-related infections (DRIs, which are associated with attachment of bacteria to these devices to form a biofilm. The latter is composed of not only bacteria but also extracellular polymeric substances (EPSes consisting of extracellular DNAs, polysaccharides, and other macromolecules. The phosphoenolpyruvate (PEP:carbohydrate phosphotransferase system (PTS regulates diverse processes of bacterial physiology. In the genome of K. pneumoniae MGH 78578, we found an uncharacterized enzyme II complex homolog of PTS: KPN00353 (EIIA homolog, KPN00352 (EIIB homolog, and KPN00351 (EIIC homolog. The aim of this study was to characterize the potential physiological role of KPN00353, KPN00352, and KPN00351 in biofilm formation by K. pneumoniae. Methods/Results: We constructed the PTS mutants and recombinant strains carrying the gene(s of PTS. The recombinant K. pneumoniae strain overexpressing KPN00353–KPN00352–KPN00351 produced more extracellular matrix than did the vector control according to transmission and scanning electron microscopy. Judging by quantification of biofilm formation, of extracellular DNA (eDNA, and of capsular polysaccharide, the recombinant strain overexpressing KPN00353-KPN00352-KPN00351 produced more biofilm and capsular polysaccharide after overnight culture and more eDNA in the log phase as compared to the vector control. Conclusion: The genes, KPN00353–KPN00352–KPN00351, encode a putative enzyme II complex in PTS and positively regulate biofilm formation by enhancing production of eDNA and capsular polysaccharide in K. pneumoniae. Five proteins related to chaperones, to the citric acid cycle, and to quorum sensing are upregulated by the KPN00353–KPN00352–KPN00351 system. Keywords: Klebsiella, PTS, Biofilm, eDNA, Polysaccharide

  6. Sensitivity Analysis of Reactor Regulating System for SMART

    International Nuclear Information System (INIS)

    Jeon, Yu Lim; Kang, Han Ok; Lee, Seong Wook; Park, Cheon Tae

    2009-01-01

    The integral reactor technology is one of the Small and Medium sized Reactor (SMR) which has recently come into a spotlight due to its suitability for various fields. SMART (System integrated Modular Advanced ReacTor), a small sized integral type PWR with a rated thermal power of 330MWt is one of the advanced SMR. SMART developed by the Korea Atomic Energy Research Institute (KAERI), has a capacity to provide 40,000 m3 per day of potable water and 90 MW of electricity (Chang et al., 2000). Figure 1 shows the SMART which adopts a sensible mixture of new innovative design features and proven technologies aimed at achieving highly enhanced safety and improved economics. Design features contributing to a safety enhancement are basically inherent safety improving features and passive safety features. Fundamental thermal-hydraulic experiments were carried out during the design concepts development to assure the fundamental behavior of major concepts of the SMART systems. A TASS/SMR is a suitable code for accident and performance analyses of SMART. In this paper, we proposed a new power control logic for stable operating outputs of Reactor Regulating System (RRS) of SMART. We analyzed the sensitivity of operating parameter for various operating conditions

  7. Proposal for an ad hoc computer network in the military electronic systems department at the military academy applying bluetooth technology

    Directory of Open Access Journals (Sweden)

    Miroslav R. Terzić

    2011-01-01

    Full Text Available The historical development of the Bluetooth module is given in the introduction of this paper. The importance of the Bluetooth standard for wireless connection on small distances is shown as well. The organization of the Department of Military Electronic Systems is presented with its area of duties, subordinate sections and deployment. The concept of a local area network for this Department, using Bluetooth technology, includes network topology and working regimes based on the main characteristics and technical specifications for the connection with Bluetooth technology. The Department's disperse computer network is proposed as a scatter net where one piconetwork includes the Head of Department and the Heads of Sections while other piconetworks are formed from the Heads of Sections and their subordinates. The security aspect of the presented network deals with basic computer network attack categories, protection methods and aspects. The paper concludes with some recommendations for the local area network using Bluetooth technology with respect to its economical and security aspects as well as to the managing principles of the Department.

  8. Homeostatic regulation of memory systems and adaptive decisions.

    Science.gov (United States)

    Mizumori, Sheri J Y; Jo, Yong Sang

    2013-11-01

    While it is clear that many brain areas process mnemonic information, understanding how their interactions result in continuously adaptive behaviors has been a challenge. A homeostatic-regulated prediction model of memory is presented that considers the existence of a single memory system that is based on a multilevel coordinated and integrated network (from cells to neural systems) that determines the extent to which events and outcomes occur as predicted. The "multiple memory systems of the brain" have in common output that signals errors in the prediction of events and/or their outcomes, although these signals differ in terms of what the error signal represents (e.g., hippocampus: context prediction errors vs. midbrain/striatum: reward prediction errors). The prefrontal cortex likely plays a pivotal role in the coordination of prediction analysis within and across prediction brain areas. By virtue of its widespread control and influence, and intrinsic working memory mechanisms. Thus, the prefrontal cortex supports the flexible processing needed to generate adaptive behaviors and predict future outcomes. It is proposed that prefrontal cortex continually and automatically produces adaptive responses according to homeostatic regulatory principles: prefrontal cortex may serve as a controller that is intrinsically driven to maintain in prediction areas an experience-dependent firing rate set point that ensures adaptive temporally and spatially resolved neural responses to future prediction errors. This same drive by prefrontal cortex may also restore set point firing rates after deviations (i.e. prediction errors) are detected. In this way, prefrontal cortex contributes to reducing uncertainty in prediction systems. An emergent outcome of this homeostatic view may be the flexible and adaptive control that prefrontal cortex is known to implement (i.e. working memory) in the most challenging of situations. Compromise to any of the prediction circuits should result in

  9. 41 CFR 101-1.101 - Federal Property Management Regulations System.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Federal Property Management Regulations System. 101-1.101 Section 101-1.101 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1...

  10. 77 FR 51783 - Federal Acquisition Regulation; Information Collection; Contractors' Purchasing Systems Reviews

    Science.gov (United States)

    2012-08-27

    ...; Information Collection; Contractors' Purchasing Systems Reviews AGENCY: Department of Defense (DOD), General... collection requirement concerning contractors' purchasing systems reviews. Public comments are particularly... Information Collection 9000- 0132, Contractors' Purchasing Systems Reviews, by any of the following methods...

  11. Hox gene regulation in the central nervous system of Drosophila

    Directory of Open Access Journals (Sweden)

    Maheshwar eGummalla

    2014-04-01

    Full Text Available Hox genes specify the structures that form along the anteroposterior (AP axis of bilateria. Within the genome, they often form clusters where, remarkably enough, their position within the clusters reflects the relative positions of the structures they specify along the AP axis. This correspondence between genomic organization and gene expression pattern has been conserved through evolution and provides a unique opportunity to study how chromosomal context affects gene regulation. In Drosophila, a general rule, often called posterior dominance, states that Hox genes specifying more posterior structures repress the expression of more anterior Hox genes. This rule explains the apparent spatial complementarity of Hox gene expression patterns in Drosophila. Here we review a noticeable exception to this rule where the more-posteriorly expressed Abd-B hox gene fails to repress the more-anterior abd-A gene in cells of the central nervous system (CNS. While Abd-B is required to repress ectopic expression of abd-A in the posterior epidermis, abd-A repression in the posterior CNS is accomplished by a different mechanism that involves a large 92kb long non-coding RNA (lncRNA encoded by the intergenic region separating abd-A and Abd-B (the iab8ncRNA. Dissection of this lncRNA revealed that abd-A is repressed by the lncRNA using two redundant mechanisms. The 1st mechanism is mediated by a microRNA (mir-iab-8 encoded by intronic sequence within the large iab8-ncRNA. Meanwhile, the second mechanism seems to involve transcriptional interference by the long iab-8 ncRNA on the abd-A promoter. Recent work demonstrating CNS-specific regulation of genes by ncRNAs in Drosophila, seem to highlight a potential role for the iab-8-ncRNA in the evolution of the Drosophila hox complexes

  12. A decision support system for the maintenance of lights of traffic regulation systems

    NARCIS (Netherlands)

    Duyn Schouten, F.A. van der; Klusener, A.S.; Vlijmen, S.F.M. van; Vos de Wael, S.L.E.

    From October 1994 to June 1995 the authors executed a project, the so called 'Lampremplace' project, in cooperation with Nederland Haarlem, a Dutch constructor and supplier of traffic regulation systems. 'Lampremplace', as it is called in traffic jargon, is the maintenance of lights of traffic

  13. A quantitative model of regulator's preference factor (RPF) in electricity-environment coordinated regulation system

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Yulong; Fu, Shijun [Economy and Business Administration School of Chongqing University, Chongqing 400030 (China)

    2010-12-15

    This paper explores quantification of regulator's preference factor (RPF) in electricity-environment coordinated regulation system. Based on social welfare economics, we articulately depict RPF's qualitative concept and its economic meaning. Then, applying abstract functions (i.e., abstract social welfare function, abstract utility function, and abstract production function), we deduce the partial-social-welfare elasticity, and build the mathematics model of maximizing social welfare. We nest this elasticity into the model's Kuhn-Tucker conditions, and obtain RPF's definition formula. By solving the Kuhn-Tucker conditions, we get RPF's quantitative formula, which solves the problem of hard to quantify regulator's preference in electricity-environment coordinated regulation system. The result shows that RPF only has relationship to subsystems' production function, and is independent of social welfare function and subsystems' utility function. Finally, we provide an empirical research based on the western region of China from year 1995 to 2004. It reveals that regulator has relative stability preference to mitigating pollutants. And validity test confirms that the empirical result is fit well to the practice. The RPF is truly a more general and valid instrument to measure regulator's preference in its regulated field. (author)

  14. DC microgrids providing frequency regulation in electrical power system - imperfect communication issues

    DEFF Research Database (Denmark)

    Bašić, Hrvoje; Dragicevic, Tomislav; Pandžić, Hrvoje

    2017-01-01

    This paper presents a model of multiple DC microgrids with battery energy storage systems and demand response capability, taking part in primary frequency regulation of electrical power system. Although DC microgrids can contribute to stability and efficiency of frequency regulation, these complex...... systems may cause serious stability issues due to the imperfect communication. This work presents possible scenarios of unstable primary frequency regulation in a simplified model of electrical power system with DC microgrids, which are controlled through communication network....

  15. Effectiveness Of Bureaucracy In The Implementation Of Free Education System In The Department Of Education Makassar City

    OpenAIRE

    Sunusi, Syahribulan

    2015-01-01

    This study aims to explain the effectiveness of the bureaucracy in organizing a free education system in Makassar City Department of Education. Deductive approach qualitative research through case studies. Data collected through observation, interviews, and documentation. Data were analyzed through data reduction techniques, presentation of data, conclusions, and verification. The effectiveness of the bureaucracy can be seen with the achievement of goals and objectives. Goals to be achieved, ...

  16. Effectiveness Of Bureaucracy In The Implementation Of Free Education System In The Department Of Education Makassar City

    OpenAIRE

    Muhammad Sawir; Rakhmat; Suryadi Lambali; Syahribulan

    2015-01-01

    Abstract This study aims to explain the effectiveness of the bureaucracy in organizing a free education system in Makassar City Department of Education. Deductive approach qualitative research through case studies. Data collected through observation interviews and documentation. Data were analyzed through data reduction techniques presentation of data conclusions and verification. The effectiveness of the bureaucracy can be seen with the achievement of goals and objectives. Goals to be achiev...

  17. Failure of a wireless voice communication system to facilitate recording of physician-patient assignment in the emergency department.

    Science.gov (United States)

    Mariani, Peter J

    2008-11-06

    A pilot study was done to assess the feasibility of using a LAN-based voice communication system to convey physician-patient assignment in the emergency department (ED). Via their communicators, physicians were expected to notify registration staff in real-time upon care assumption of each new patient. Over a two month trial, compliance went from poor to dismal, and this method of notification was abandoned.

  18. Impact of a computerized provider radiography order entry system without clinical decision support on emergency department medical imaging requests.

    Science.gov (United States)

    Claret, Pierre-Géraud; Bobbia, Xavier; Macri, Francesco; Stowell, Andrew; Motté, Antony; Landais, Paul; Beregi, Jean-Paul; de La Coussaye, Jean-Emmanuel

    2016-06-01

    The adoption of computerized physician order entry is an important cornerstone of using health information technology (HIT) in health care. The transition from paper to computer forms presents a change in physicians' practices. The main objective of this study was to investigate the impact of implementing a computer-based order entry (CPOE) system without clinical decision support on the number of radiographs ordered for patients admitted in the emergency department. This single-center pre-/post-intervention study was conducted in January, 2013 (before CPOE period) and January, 2014 (after CPOE period) at the emergency department at Nîmes University Hospital. All patients admitted in the emergency department who had undergone medical imaging were included in the study. Emergency department admissions have increased since the implementation of CPOE (5388 in the period before CPOE implementation vs. 5808 patients after CPOE implementation, p=.008). In the period before CPOE implementation, 2345 patients (44%) had undergone medical imaging; in the period after CPOE implementation, 2306 patients (40%) had undergone medical imaging (p=.008). In the period before CPOE, 2916 medical imaging procedures were ordered; in the period after CPOE, 2876 medical imaging procedures were ordered (p=.006). In the period before CPOE, 1885 radiographs were ordered; in the period after CPOE, 1776 radiographs were ordered (pmedical imaging did not vary between the two periods. Our results show a decrease in the number of radiograph requests after a CPOE system without clinical decision support was implemented in our emergency department. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Optimizing cardiology capacity to reduce emergency department boarding: a systems engineering approach.

    Science.gov (United States)

    Levin, Scott R; Dittus, Robert; Aronsky, Dominik; Weinger, Matthew B; Han, Jin; Boord, Jeffrey; France, Daniel

    2008-12-01

    Patient safety and emergency department (ED) functionality are compromised when inefficient coordination between hospital departments impedes ED patients' access to inpatient cardiac care. The objective of this study was to determine how bed demand from competing cardiology admission sources affects ED patients' access to inpatient cardiac care. A stochastic discrete event simulation of hospital patient flow predicted ED patient boarding time, defined as the time interval between cardiology admission request to inpatient bed placement, as the primary outcome measure. The simulation was built and tested from 1 year of patient flow data and was used to examine prospective strategies to reduce cardiology patient boarding time. Boarding time for the 1,591 ED patients who were admitted to the cardiac telemetry unit averaged 5.3 hours (median 3.1, interquartile range 1.5-6.9). Demographic and clinical patient characteristics were not significant predictors of boarding time. Measurements of bed demand from competing admission sources significantly predicted boarding time, with catheterization laboratory demand levels being the most influential. Hospital policy required that a telemetry bed be held for each electively scheduled catheterization patient, yet the analysis revealed that 70.4% (95% CI 51.2-92.5) of these patients did not transfer to a telemetry bed and were discharged home each day. Results of simulation-based analyses showed that moving one afternoon scheduled elective catheterization case to before noon resulted in a 20-minute reduction in average boarding time compared to a 9-minute reduction achieved by increasing capacity by one additional telemetry bed. Scheduling and bed management practices based on measured patient transfer patterns can reduce inpatient bed blocking, optimize hospital capacity, and improve ED patient access.

  20. [Satisfaction according to health care insurance systems in an emergency department].

    Science.gov (United States)

    Dávila, F A; Herrera, J S; Yasnó, D A; Forero, L C; Alvarado, M V

    Health satisfaction is a fundamental measure of the quality of health services. This study aims to validate and analyse the results of a quality of care questionnaire to assess the level of satisfaction of patients attended in the emergency department of a high complexity hospital. Observational, cross-sectional study, with a questionnaire designed to assess the quality of service and satisfaction at the end of care in the emergency department. Descriptive statistics of scale were established and presented, as well as determining the construct validity, overall reliability, internal and concurrent validity of an overall against a uni-dimensional scale. A total of 5,961 records were reviewed, most of them (77.3%) reported by patients in the Mandatory Health Plan. High levels of satisfaction overall and by subgroups were found. There were no significant differences between subgroups, with 86.8 for those with Pre-paid Medical Care Plan and 84.4 for mandatory health plan. Cronbach's alpha for the questionnaire was 0.90. The questionnaire proved to be reliable and valid in determining the quality and satisfaction with care. The results showed high levels of satisfaction overall and in the domains. A low consistency between the results of the multidimensional and unidimensional satisfaction scales suggests that there were aspects of satisfaction not investigated on the multidimensional scale. Ecologically-designed before and after studies are required to evaluate the effectiveness of interventions in satisfaction. Copyright © 2016 SECA. Publicado por Elsevier España, S.L.U. All rights reserved.

  1. Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease.

    Science.gov (United States)

    Takaya, Akiko; Tabuchi, Fumiaki; Tsuchiya, Hiroko; Isogai, Emiko; Yamamoto, Tomoko

    2008-06-01

    Lon protease, a member of the ATP-dependent protease family, regulates numerous cellular systems by degrading specific substrates. Here, we demonstrate that Lon is involved in the regulation of quorum-sensing (QS) signaling systems in Pseudomonas aeruginosa, an opportunistic human pathogen. The organism has two acyl-homoserine lactone (HSL)-mediated QS systems, LasR/LasI and RhlR/RhlI. Many reports have demonstrated that these two systems are regulated and interconnected by global regulators. We found that lon-disrupted cells overproduce pyocyanin, the biosynthesis of which depends on the RhlR/RhlI system, and show increased levels of a transcriptional regulator, RhlR. The QS systems are organized hierarchically: the RhlR/RhlI system is subordinate to LasR/LasI. To elucidate the mechanism by which Lon negatively regulates RhlR/RhlI, we examined the effect of lon disruption on the LasR/LasI system. We found that Lon represses the expression of LasR/LasI by degrading LasI, an HSL synthase, leading to negative regulation of the RhlR/RhlI system. RhlR/RhlI was also shown to be regulated by Lon independently of LasR/LasI via regulation of RhlI, an HSL synthase. In view of these findings, it is suggested that Lon protease is a powerful negative regulator of both HSL-mediated QS systems in P. aeruginosa.

  2. The Mucosal Immune System and Its Regulation by Autophagy.

    Science.gov (United States)

    Kabat, Agnieszka M; Pott, Johanna; Maloy, Kevin J

    2016-01-01

    The gastrointestinal tract presents a unique challenge to the mucosal immune system, which has to constantly monitor the vast surface for the presence of pathogens, while at the same time maintaining tolerance to beneficial or innocuous antigens. In the intestinal mucosa, specialized innate and adaptive immune components participate in directing appropriate immune responses toward these diverse challenges. Recent studies provide compelling evidence that the process of autophagy influences several aspects of mucosal immune responses. Initially described as a "self-eating" survival pathway that enables nutrient recycling during starvation, autophagy has now been connected to multiple cellular responses, including several aspects of immunity. Initial links between autophagy and host immunity came from the observations that autophagy can target intracellular bacteria for degradation. However, subsequent studies indicated that autophagy plays a much broader role in immune responses, as it can impact antigen processing, thymic selection, lymphocyte homeostasis, and the regulation of immunoglobulin and cytokine secretion. In this review, we provide a comprehensive overview of mucosal immune cells and discuss how autophagy influences many aspects of their physiology and function. We focus on cell type-specific roles of autophagy in the gut, with a particular emphasis on the effects of autophagy on the intestinal T cell compartment. We also provide a perspective on how manipulation of autophagy may potentially be used to treat mucosal inflammatory disorders.

  3. Cholesterol: Its Regulation and Role in Central Nervous System Disorders

    Directory of Open Access Journals (Sweden)

    Matthias Orth

    2012-01-01

    Full Text Available Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol-rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain. Cholesterol is tightly regulated between the major brain cells and is essential for normal brain development. The metabolism of brain cholesterol differs markedly from that of other tissues. Brain cholesterol is primarily derived by de novo synthesis and the blood brain barrier prevents the uptake of lipoprotein cholesterol from the circulation. Defects in cholesterol metabolism lead to structural and functional central nervous system diseases such as Smith-Lemli-Opitz syndrome, Niemann-Pick type C disease, and Alzheimer’s disease. These diseases affect different metabolic pathways (cholesterol biosynthesis, lipid transport and lipoprotein assembly, apolipoproteins, lipoprotein receptors, and signaling molecules. We review the metabolic pathways of cholesterol in the CNS and its cell-specific and microdomain-specific interaction with other pathways such as the amyloid precursor protein and discuss potential treatment strategies as well as the effects of the widespread use of LDL cholesterol-lowering drugs on brain functions.

  4. 3D simulation of CANDU reactor regulating system

    International Nuclear Information System (INIS)

    Venescu, B.; Zevedei, D.; Jurian, M.

    2013-01-01

    Present paper shows the evaluation of the performance of the 3-D modal synthesis based reactor kinetic model in a closed-loop environment in a MATLAB/SIMULINK based Reactor Regulating System (RRS) simulation platform. A notable advantage of the 3-D model is the level of details that it can reveal as compared to the coupled point kinetic model. Using the developed RRS simulation platform, the reactor internal behaviours can be revealed during load-following tests. The test results are also benchmarked against measurements from an existing (CANDU) power plant. It can be concluded that the 3-D reactor model produces more realistic view of the core neutron flux distribution, which is closer to the real plant measurements than that from a coupled point kinetic model. It is also shown that, through a vectorization process, the computational load of the 3-D model is comparable with that of the 14-zone coupled point kinetic model. Furthermore, the developed Graphical User Interface (GUI) software package for RRS implementation represents a user friendly and independent application environment for education training and industrial utilizations. (authors)

  5. Evaluating sustainability of truck weight regulations: A system dynamics view

    Directory of Open Access Journals (Sweden)

    Pei Liu

    2015-11-01

    Full Text Available Purpose: Targeting the problem of overload trucking in Highway Transportation of iron ore from Caofeidian to Tangshan (HTCT, this paper aims to assess long-term effects of alternative Truck Weight Regulation (TWR policies on sustainability of HTCT. Design/methodology/approach: A system dynamics model was established for policy evaluation. The model, composed of six interrelating modules, is able to simulate policies effects on trucking issues such as freight flow, truck traffic flow, pavement performance, highway transport capacity and trucking time, and further on the Cumulative Economic Cost (CEC including transport cost and time cost of freight owners and the Cumulative Social Cost (CSC including pavement maintenance cost, green house gas emission cost, air pollutants emission cost and traffic accidents cost, so the effects of TWR policies on sustainability of HTCT could be evaluated. Findings: According to different values of overload ratio which a TWR policy allows, alternative TWR policies are classified into three types, which are The Rigid Policy (TRP, The Moderate Policy (TMP and The Tolerant Policy (TTP. Results show that the best policy for sustainability of HTCT depends on the importance of CSC which is expected by the local government. To be specific, (1 if CSC is considered much less important than CEC, the local government should continue implementing the current TTP with the maximum overload ratio; (2 if CSC is considered much more important than CEC, then TRP is recommended; and (3 if CSC is considered slightly more important than CES, TMP with overload ratio of 80% is the best. Practical implications: Conclusions of this paper may help the local government design appropriate TWR policies to achieve sustainability of HTCT. Originality/value: To the best of our knowledge, this is the first effort to evaluate TWR policies on sustainability of regional freight transportation based on system dynamics modeling.

  6. Department of Genetics

    International Nuclear Information System (INIS)

    2000-01-01

    Full text: There are five independent research groups in the Department conducting the following lines of investigations: 1. Regulation of sulfur amino acid metabolism in fungi, focusing on cloning and characterisation of structural and regulatory genes in Aspergillus nidulans. 2. Identification and characterization of S. cerevisiae genes involved in the regulation of tRNA biosynthesis and control of translation fidelity in cytosolic and mitochondrial systems. 3. Mechanism of DNA repair and mutagenesis by using mutations in DNA polymerases, mismatch repair and radiation sensitivity genes to study their influence on the generation of mutations in nondividing, resting cells (adaptive mutations) in S. cerevisiae. 4. Pleiotropic effects of the S. cerevisiae IRR1 gene, particularily on colony formation and sister chromatid cohesion. 5. Regulation of heme synthesis in S. cerevisiae: the analysis of structure-function relationship of ferrochelatase (the last enzyme of the pathway). 6. Role of RSP5 the ubiquitin-protein ligase of S. cerevisiae in protein import to mitochondria and endocytosis of plasma membrane proteins. 7. Molecular analysis of the glucose-6-phosphate dehydrogenase gene in Polish 6-GDP deficient subjects. 8. Genetic and phylogenic studies of the Polish Bison bonasus population with the use of nuclear and mitochondrial markers

  7. Contribution to the study of Arapey Salto-Aquifer System (Department of Salto - Uruguay)

    International Nuclear Information System (INIS)

    Massa, E.

    1994-01-01

    This paper provide hydrogeological data about the Salto Arapey aquifer system constituted by sedimentary deposits and fisurate effusive rocks, respectively Tertiary and Cretacic aged. The information belongs to an area located at latitude South 31º20' West. North of the Salto city (NW of Uruguay) 500 km away from Montevideo. A regional aquifer system can be defined where the biggest flows are originated in the basaltic fisurate d rocks of the Arapey formation. Environment features are also considered and data about the main polluting agents - both organic and inorganic ones- are provided, bearing in mind that they justify an urgent safety design to protect the aquifer system

  8. Adolescents' Self-Regulation Development via the Sensory Room System

    Science.gov (United States)

    Kalimullin, Aydar M.; Kuvaldina, Elana A.; Koinova-Zoellner, Julia

    2016-01-01

    The urgency of the issue stated in this article is caused by the need for mastering skills and patterns of self-regulation when being an adolescent since this time is sensitive for developing processes of personal understanding and evolution. Thus, mastering skills and patterns of self-regulation as a necessary part of the whole ability of…

  9. Design of a Financial Management System for the Academic Departments at the Naval Postgraduate School

    National Research Council Canada - National Science Library

    Pires, Alan

    1997-01-01

    .... After comparing the traditional waterfall approach to the rapid prototyping approach, we elected to use rapid prototyping in order to develop the system quickly and to help the users determine their own requirements...

  10. HL7 and DICOM based integration of radiology departments with healthcare enterprise information systems.

    Science.gov (United States)

    Blazona, Bojan; Koncar, Miroslav

    2007-12-01

    Integration based on open standards, in order to achieve communication and information interoperability, is one of the key aspects of modern health care information systems. However, this requirement represents one of the major challenges for the Information and Communication Technology (ICT) solutions, as systems today use diverse technologies, proprietary protocols and communication standards which are often not interoperable. One of the main producers of clinical information in healthcare settings represent Radiology Information Systems (RIS) that communicate using widely adopted DICOM (Digital Imaging and COmmunications in Medicine) standard, but in very few cases can efficiently integrate information of interest with other systems. In this context we identified HL7 standard as the world's leading medical ICT standard that is envisioned to provide the umbrella for medical data semantic interoperability, which amongst other things represents the cornerstone for the Croatia's National Integrated Healthcare Information System (IHCIS). The aim was to explore the ability to integrate and exchange RIS originated data with Hospital Information Systems based on HL7's CDA (Clinical Document Architecture) standard. We explored the ability of HL7 CDA specifications and methodology to address the need of RIS integration HL7 based healthcare information systems. We introduced the use of WADO service interconnection to IHCIS and finally CDA rendering in widely used Internet explorers. The outcome of our pilot work proves our original assumption of HL7 standard being able to adopt radiology data into the integrated healthcare systems. Uniform DICOM to CDA translation scripts and business processes within IHCIS is desired and cost effective regarding to use of supporting IHCIS services aligned to SOA.

  11. Department of Energy environmental management complex-wide integration using systems engineering

    International Nuclear Information System (INIS)

    Fairbourn, P.

    1997-01-01

    A systems engineering approach was successfully used to recommend changes to environmental management activities across the DOE Complex. A team of technical experts and systems engineers developed alternatives that could save tax payers billions of dollars if the barriers are removed to allow complete implementation. The alternatives are technically-based and defensible, and are being worked through the stakeholder review process. The integration process and implementing project structure are both discussed

  12. Application of System and Integration Readiness Levels to Department of Defense Research and Development

    Science.gov (United States)

    2016-07-01

    prompting folding foot-pegs. The human-motorcycle interface maturity followed the technical maturity at the expense of safety. Early airplanes were...this paper shows matrix notation in both reduced tensor notation and matrix notation as a convenience for a multidisciplinary audience. SRLj, [SRL...index for managing the acquisition of defense systems. Paper presented at National Defense Industrial Association 13th Annual Systems Engineering

  13. Shock stability in systems that change type. Final grant report to the Department of Energy

    International Nuclear Information System (INIS)

    Keyfitz, B.L.

    1995-01-01

    The aim of the original project was to investigate systems of conservation laws that change type. Progress was made on this problem. During the last period of the grant, the author began an investigation of a multidimensional system related to Mach reflection which goes beyond the original work proposed. This has been fruitful direction in which to apply expertise on change of type. Some basic theoretical results have been found

  14. [Development of a System to Use Patient's Information Which is Required at the Radiological Department].

    Science.gov (United States)

    Satoh, Akihiro

    2016-04-01

    The purpose of this study is to develop a new system to get and share some data of a patient which are required for a radiological examination not using an electronic medical chart or a radiological information system (RIS), and also to demonstrate that this system is operated on cloud technology. I used Java Enterprise Edition (Java EE) as a programing language and MySQL as a server software, and I used two laptops as hardware for client computer and server computer. For cloud computing, I hired a server of Google App Engine for Java (GAE). As a result, I could get some data of the patient required at his/her examination instantly using this system. This system also helps to improve the efficiency of examination. For example, it has been useful when I want to decide radiographic condition or to create CT images such as multi-planar reconstruction (MPR) or volume rendering (VR). When it comes to cloud computing, the GAE was used experimentally due to some legal restrictions. From the above points it is clear that this system has played an important role in radiological examinations, but there has been still few things which I have to resolve for cloud computing.

  15. 77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2012-02-24

    ...D published an initial proposed rule for Business Systems-- Definition and Administration (DFARS... the definition and administration of contractor business systems as follows: A. Contractor business..., 245, and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems...

  16. Systemic Effect of Angipars on Regulation of Wound Healing is ...

    African Journals Online (AJOL)

    1Physiology-Pharmacology Research Center, 2Molecular Medicine Research Center, 3Department of Biology, ... tissues of wounds of diabetics following treatment with insulin, angipars (a .... GS-700 Imaging Densitometer using Molecular.

  17. The Department of Energy Nevada Test Site Remote Area Monitoring System

    International Nuclear Information System (INIS)

    Sanders, L.D.; Hart, O.F.

    1993-01-01

    The Remote Area Monitoring System was developed by Los Alamos National Laboratory (LANL) for DOE test directors at the Nevada Test Site (NTS) to verify radiological conditions are safe after a nuclear test. In the unlikely event of a venting as a result of a nuclear test, this system provides radiological and meteorological data to Weather Service Nuclear Support Office (WSNSO) computers where mesoscale models are used to predict downwind exposure rates. The system uses a combination of hardwired radiation sensors and satellite based data acquisition units with their own radiation sensors to measure exposure rates in remote areas of the NTS. The satellite based data acquisition units are available as small, Portable Remote Area Monitors (RAMs) for rapid deployment, and larger, Semipermanent RAMs that can have meteorological towers. The satellite based stations measure exposure rates and transmit measurements to the GOES (Geostationary Operational Environmental Satellite) where they are relayed to Direct Readout Ground Stations (DRGS) at the NTS and Los Alamos. Computers process the data and display results in the NTS Operations Coordination Center. Los Alamos computers and NTS computers are linked together through a wide area network, providing remote redundant system capability. Recently, LANL, expanded the system to take radiological and meteorological measurements in communities in the western United States. The system was also expanded to acquire data from Remote Automatic Weather Stations (RAWS) that transmit through GOES. The addition of Portable and Semipermanent RAMs to the system has vastly expanded monitoring capabilities at NTS and can be used to take measurements anywhere in this hemisphere

  18. Effectiveness Of Bureaucracy In The Implementation Of Free Education System In The Department Of Education Makassar City

    Directory of Open Access Journals (Sweden)

    Muhammad Sawir

    2015-04-01

    Full Text Available Abstract This study aims to explain the effectiveness of the bureaucracy in organizing a free education system in Makassar City Department of Education. Deductive approach qualitative research through case studies. Data collected through observation interviews and documentation. Data were analyzed through data reduction techniques presentation of data conclusions and verification. The effectiveness of the bureaucracy can be seen with the achievement of goals and objectives. Goals to be achieved namely an increase in the quality of learners and students accepted in public schools as well as excellent schools higher education. While the targets are achieved namely ease the cost burden of parents and educators to the addition of income and education in the implementation of free education system in Makassar City Department of Education. Based on the results of the research program of free education free education program in the Department of Education of Makassar achieve the look of 1 the percentage of dropouts decreased 2 continuing education enrollment rates increased 3 grade repetition rate learn remedial is reduced 4 increased student graduation rates and 5 increased number of continuing education. With the achievement of these targets the targets of free education in Makassar effective. In addition the implementation of free education beneficial to the improvement of school facilities and infrastructure such as improved classrooms leaking roofs and repair other means. Repair facilities and infrastructure for elementary school-high school showed a significant improvement.

  19. Focused Lens on Unmanned Aerial Systems: An Evaluation of Department of Defense’s Unmanned Aerial Vision 2011

    Science.gov (United States)

    2014-06-13

    Break Free of Regulations.” 69Barbara Opall -Rome, “ Israel Tackles The Last Frontier Of UAS Technology: Israel Moves Closer Toward Flying UASs In...with the new F-35 Joint Strike Fighter once it comes online, or with helicopters aboard the Littoral Combat Ship. Unmanned mine hunters could operate...Office, 2002. ———. Unmanned Aircraft Systems Roadmap 2005-2030. Washington, DC: Government Publishing Office, 2005. Opall -Rome, Barbra. “Israel

  20. Trial of a small image network system in a radiology department of an university hospital

    International Nuclear Information System (INIS)

    Kasuga, Toshio; Sone, Shusuke; Izuno, Itaru; Oguchi, Kazuhiro; Aoki, Jun; Sakai, Fumikazu; Takizawa, Masaomi; Hosoba, Minoru; Yamaguchi, Kenji.

    1995-01-01

    This paper describes the construction of an image network system in Shinshu University Hospital, and some of its current issues and advantages. Our discussion is based on our experience with a PACS system. SAIPACS, which was installed in 1990 for use in clinical conferencing and pre- and post-graduate education, and with a new CT and MRI network, which was subsequently introduced in 1993. The SAIPACS interconnects eight digital imaging modalities, including CT, MRI, XTV-DR (including digital tomosynthesis), FCR, nuclear medicine (RI), DSA, US, and a film digitizer (FD), with a workstation. Transmission time from the magnetic disk of each imaging modality to the SAIPACS image disk is not rapid enough. Therefore, we need to select image for transfer that are pertinent to our specific purpose, to complete image transmission within a practically acceptable period of time. The new CT/MRI network is composed of two CT units, two MRI systems, an image processing unit and a Universal Gateway. It provides faster image transmission than the SAIPACS system, because there is no need to reform image data to send them in a reversible compressed form. A versatile network system connected to the SAIPACS and CT/MRI network enables digital image data to be processed and edited and images to be transferred back to SAIPACS for clinical or educational use. (author)

  1. Department of Defense need for a micro-electromechanical systems (MEMS) reliability assessment program

    Science.gov (United States)

    Zunino, James L., III; Skelton, Donald

    2005-01-01

    As the United States (U.S.) Army transforms into a lighter, more lethal, and more agile force, the technologies that support both legacy and emerging weapon systems must decrease in size while increasing in intelligence. Micro-electromechanical systems (MEMS) are one such technology that the Army as well as entire DOD will heavily rely on in achieving these objectives. Current and future military applications of MEMS devices include safety and arming devices, guidance systems, sensors/detectors, inertial measurement units, tracking devices, radio frequency devices, wireless radio frequency identification (RFID), etc. Even though the reliance on MEMS devices has been increasing, there have been no studies performed to determine their reliability and failure mechanisms. Furthermore, no standardized test protocols exist for assessing reliability. Accordingly, the U.S. Army Corrosion Office at Picatinny, NJ has initiated the MEMS Reliability Assessment Program to address this issue.

  2. DEPARTMENTS OF INTERNATIONAL CONNECTIONS OF THE HIGHER LEARNING INSTITUTIONS AS INTEGRATION CENTRES OF NATIONAL EDUCATION INTO THE WORLD SYSTEM

    Directory of Open Access Journals (Sweden)

    Т. Д. Антонюк

    2014-04-01

    Full Text Available The object for research in this article are departments of international connections of the Ukrainian  higher educational  institutions, becoming of which happened at the beginning of 90th of the ХХ th century. International cooperation in the field of education is an important norm of the Bologna Declaration, as actually facilitates increase of mobility of teachers and students, independence of students, their level of self-organization.The purpose of this article is an analysis of the international cooperation departments activities of higher educational institutions of Ukraine as an effective mechanism for the integration of Ukrainian higher education system in the global educational community.Making preparations of the article we conformed to scientific methods of cognition, and also historical methods. We succeeded in  analysis of activity of international connections departments of  higher educational institutions thanks to using of methods of search, analysis and synthesis of empiric material.With accession of Ukraine to the Council of Europe and joining to the Bologna Declaration, there emerged a need for the formation of new structural subdivisions in the higher educational institutions  - departments of international connections.Contacts with higher educational establishments of foreign countries grew into an important resource for rise of the employees qualification by realization of common scientific researches, organization of internship of faculty and student staff.Some features depending on the specific of  personnels training and profile of university take place in activity of departments of international connections of every higher educational institution. However directions and tasks in the general measuring remain identical for the departments of international connections of all  universities.Departments of international connections are the important centers of international activity of higher educational institutions

  3. Fundamentals of Adaptive Intelligent Tutoring Systems for Self-Regulated Learning

    Science.gov (United States)

    2015-03-01

    ARL-SR-0318 ● MAR 2015 US Army Research Laboratory Fundamentals of Adaptive Intelligent Tutoring Systems for Self-Regulated...Adaptive Intelligent Tutoring Systems for Self-Regulated Learning by Robert A Sottilare Human Research and Engineering Directorate, ARL...TITLE AND SUBTITLE Fundamentals of Adaptive Intelligent Tutoring Systems for Self-Regulated Learning 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  4. Robust Fuzzy Control for Fractional-Order Uncertain Hydroturbine Regulating System with Random Disturbances

    OpenAIRE

    Fengjiao Wu; Guitao Zhang; Zhengzhong Wang

    2016-01-01

    The robust fuzzy control for fractional-order hydroturbine regulating system is studied in this paper. First, the more practical fractional-order hydroturbine regulating system with uncertain parameters and random disturbances is presented. Then, on the basis of interval matrix theory and fractional-order stability theorem, a fuzzy control method is proposed for fractional-order hydroturbine regulating system, and the stability condition is expressed as a group of linear matrix inequalities. ...

  5. Power Generation and Transportation Systems Research Department: 1992 annual status report (Gas Research Institute)

    International Nuclear Information System (INIS)

    Benedict, A.

    1992-09-01

    Activities of Gas Research Institute's Power Generation and Transportation Systems subprogram for the period between October 1, 1991 and September 30, 1992 are summarized. The particular project areas covered in the report are Cogeneration and Power Systems, Engine Technology and Component Development, Natural Gas Vehicles Research, and Electric Power Generation. For each project area a separate chapter is provided. Each chapter includes a rationale for funding the research effort, the goals and objectives to be achieved, a general statement on research accomplishments, and the strategy employed in the project area. Each chapter also contains a series of summary reports on the status of each contract

  6. Operations of the LR56 radioactive liquid cask transport system at U.S. Department of Energy sites

    International Nuclear Information System (INIS)

    Davidson, J.S.; Hornstra, D.J.; Sazawal, V.K.; Clement, G.

    1996-01-01

    The LR56 cask system is licensed for use in France under Certificate of Compliance F/309/B(U)F for transport of 4,000-liter volumes of radioactive liquids. Three LR56 cask systems (with modifications for use at Department of Energy (DOE) sites) have been purchased for delivery at the Hanford Site, Oak Ridge National Laboratory (ORNL), and Savannah River Site (SRS). The LR56 cask systems will be used for on-site transfers of Type B quantities of radioactive liquid waste. The ORNL unit will also be used as a Type A packaging for transfers of radioactive liquids between DOE sites. This paper discusses LR56 operating features and the use of the cask system at the three DOE sites

  7. 75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-03

    ..., et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition and... Regulation Supplement; Business Systems--Definition and Administration (DFARS Case 2009-D038) AGENCY: Defense.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  8. US Department of Energy National Solid Waste Information Management System (NSWIMS): Annual report for calendar year 1987

    Energy Technology Data Exchange (ETDEWEB)

    Scott, W.L.

    1988-07-01

    The Solid Waste Information Management System (SWIMS) is the database used to gather information for the US Department of Energy (DOE) on DOE and Department of Defense solid low-level radioactive waste (LLW). The National SWIMS Annual Report (NSWIMS) provides officials of the DOE with management information on the entire DOE/defense solid LLW cycle. The acronym for the annual report, NSWIMS, signifies that an improved format has been developed to make this document a more useful tool for assessing solid LLW management performance. Part I provides a composite summary of the DOE/defense solid LLW management. It includes data related to waste generation, forecasting, treatment, and disposal. Part II contains SWIMS computer-supplied information with discussions of the data presented, standardized and simplified data tables, and revised figures. All data are presented without interpretation and are potentially useful to users for evaluating trends, identifying possible problem areas, and defining future implications. 33 figs., 29 tabs.

  9. Impact of the ABCDE triage in primary care emergency department on the number of patient visits to different parts of the health care system in Espoo City

    Directory of Open Access Journals (Sweden)

    Kantonen Jarmo

    2012-01-01

    Full Text Available Abstract Background Many Finnish emergency departments (ED serve both primary and secondary health care patients and are therefore referred to as combined emergency departments. Primary care doctors are responsible for the initial assessment and treatment. They, thereby, also regulate referral and access to secondary care. Primary health care EDs are easy for the public to access, leading to non-acute patient visits to the emergency department. This has caused increased queues and unnecessary difficulties in providing immediate treatment for urgent patients. The primary aim of this study was to assess whether the flow of patients was changed by implementing the ABCDE-triage system in the EDs of Espoo City, Finland. Methods The numbers of monthly visits to doctors were recorded before and after intervention in Espoo primary care EDs. To study if the implementation of the triage system redirects patients to other health services, the numbers of monthly visits to doctors were also scored in the private health care, the public sector health services of Espoo primary care during office hours and local secondary health care ED (Jorvi hospital. A face-to-face triage system was applied in the primary care EDs as an attempt to provide immediate treatment for the most acute patients. It is based on the letters A (patient sent directly to secondary care, B (to be examined within 10 min, C (to be examined within 1 h, D (to be examined within 2 h and E (no need for immediate treatment for assessing the urgency of patients' treatment needs. The first step was an initial patient assessment by a health care professional (triage nurse. The introduction of this triage system was combined with information to the public on the "correct" use of emergency services. Results After implementation of the ABCDE-triage system the number of patient visits to a primary care doctor decreased by up to 24% (962 visits/month as compared to the three previous years in the EDs

  10. A Modernization Plan for the Technical Data Department of the Naval Ships Weapon Systems Engineering Station

    Science.gov (United States)

    1976-09-01

    intergration plan showing the relationship of all phases to the end objective. 17 c. A timing plan to coordinate milestones within each phase as they...per system, horizontally rotated between two read/record units contained in the laser recorder unit. Each read/record unit is independent, which

  11. Developing performance measurement systems as enabling formalization : A longitudinal field study of a logistics department

    NARCIS (Netherlands)

    Wouters, Marc; Wilderom, Celeste P.M.

    2008-01-01

    This paper reports on a developmental approach to performance-measurement systems (PMS). In particular, we look at characteristics of a development process that result in the PMS being perceived by employees as enabling of their work, rather than as primarily a control device for use by senior

  12. An assessment of a film enhancement system for use in a radiation therapy department.

    Science.gov (United States)

    Solowsky, E L; Reinstein, L E; Meek, A G

    1990-01-01

    The clinical uses of a radiotherapy film enhancement system are explored. The primary functions of the system are to improve the quality of poorly exposed simulator and portal films, and to perform comparisons between the two films to determine whether patient or block positioning errors are present. Other features include: the production of inexpensive, high quality hardcopy images of simulation films and initial portal films for chart documentation, the capacity to overlay lateral simulation films with sagittal MRI films to aid in field design, and a mode to zoom in on individual CT or MRI images and enlarge them for video display during chart rounds or instructional sessions. This commercially available system is comprised of a microcomputer, frame grabber, CCD camera with zoom lens, and a high-resolution thermal printer. The user-friendly software is menu driven and utilizes both keyboard and track ball to perform its functions. At the heart of the software is a very fast Adaptive Histogram Equalization (AHE) routine, which enhances and improves the readability of most portal films. The system has been evaluated for several disease sites, and its advantages and limitations will be presented.

  13. Review of Bruce A reactor regulating system software

    International Nuclear Information System (INIS)

    1995-12-01

    Each of the four reactor units at the Ontario Hydro Bruce A Nuclear Generating Station is controlled by the Reactor Regulating System (RRS) software running on digital computers. This research report presents an assessment of the quality and reliability of the RRS software based on a review of the RRS design documentation, an analysis of certain significant Event Reports (SERs), and an examination of selected software changes. We found that the RRS software requirements (i.e., what the software should do) were never clearly documented, and that design documents, which should describe how the requirements are implemented, are incomplete and inaccurate. Some RRS-related SERs (i.e., reports on unexpected incidents relating to the reactor control) implied that there were faults in the RRS, or that RRS changes should be made to help prevent certain unexpected events. The follow-up investigations were generally poorly documented, and so it could not usually be determined that problems were properly resolved. The Bruce A software change control procedures require improvement. For the software changes examined, there was insufficient evidence provided by Ontario Hydro that the required procedures regarding change approval, independent review, documentation updates, and testing were followed. Ontario Hydro relies on the expertise of their technical staff to modify the RRS software correctly; they have confidence in the software code itself, even if the documentation is not up-to-date. Ontario Hydro did not produce the documentation required for an independent formal assessment of the reliability of the RRS. (author). 37 refs., 3 figs

  14. Review of Bruce A reactor regulating system software

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    Each of the four reactor units at the Ontario Hydro Bruce A Nuclear Generating Station is controlled by the Reactor Regulating System (RRS) software running on digital computers. This research report presents an assessment of the quality and reliability of the RRS software based on a review of the RRS design documentation, an analysis of certain significant Event Reports (SERs), and an examination of selected software changes. We found that the RRS software requirements (i.e., what the software should do) were never clearly documented, and that design documents, which should describe how the requirements are implemented, are incomplete and inaccurate. Some RRS-related SERs (i.e., reports on unexpected incidents relating to the reactor control) implied that there were faults in the RRS, or that RRS changes should be made to help prevent certain unexpected events. The follow-up investigations were generally poorly documented, and so it could not usually be determined that problems were properly resolved. The Bruce A software change control procedures require improvement. For the software changes examined, there was insufficient evidence provided by Ontario Hydro that the required procedures regarding change approval, independent review, documentation updates, and testing were followed. Ontario Hydro relies on the expertise of their technical staff to modify the RRS software correctly; they have confidence in the software code itself, even if the documentation is not up-to-date. Ontario Hydro did not produce the documentation required for an independent formal assessment of the reliability of the RRS. (author). 37 refs., 3 figs.

  15. The Kdp-ATPase system and its regulation

    Indian Academy of Sciences (India)

    Madhu Sudhan

    2007-03-15

    Mar 15, 2007 ... rice paddy fields) shows a strong dependence on K+ for normal growth ... The possible mechanism(s) of regulation of the unique kdp operons from Anabaena .... of that bacterium during osmotic stress and low temperature.

  16. Endangered Butterflies as a Model System for Managing Source Sink Dynamics on Department of Defense Lands

    Science.gov (United States)

    used three species of endangered butterflies as a model system to rigorously investigate the source-sink dynamics of species being managed on military...lands. Butterflies have numerous advantages as models for source-sink dynamics , including rapid generation times and relatively limited dispersal, but...they are subject to the same processes that determine source-sink dynamics of longer-lived, more vagile taxa.1.2 Technical Approach: For two of our

  17. Validating the implementation of the triage system in an emergency department in a University Hospital

    Directory of Open Access Journals (Sweden)

    Abdulaziz Bin Saeed

    2017-01-01

    Conclusion: The nurses' overall results were below expectations. Statistically significant variables affecting correct categorisation included age, experience, education level and nationality of the nurses. Nurses above the age of 45 years with more years of experience, obtained top scores. Nurses with the highest level of education also scored significantly higher. Filipino nurses scored better than nurses of other nationalities. With the widespread utilisation of triage systems in the region, further studies that evaluate their implementation are needed.

  18. Dynamic Model of Kaplan Turbine Regulating System Suitable for Power System Analysis

    Directory of Open Access Journals (Sweden)

    Jie Zhao

    2015-01-01

    Full Text Available Accurate modeling of Kaplan turbine regulating system is of great significance for grid security and stability analysis. In this paper, Kaplan turbine regulating system model is divided into the governor system model, the blade control system model, and the turbine and water diversion system model. The Kaplan turbine has its particularity, and the on-cam relationship between the wicket gate opening and the runner blade angle under a certain water head on the whole range was obtained by high-order curve fitting method. Progressively the linearized Kaplan turbine model, improved ideal Kaplan turbine model, and nonlinear Kaplan turbine model were developed. The nonlinear Kaplan turbine model considered the correction function of the blade angle on the turbine power, thereby improving the model simulation accuracy. The model parameters were calculated or obtained by the improved particle swarm optimization (IPSO algorithm. For the blade control system model, the default blade servomotor time constant given by value of one simplified the modeling and experimental work. Further studies combined with measured test data verified the established model accuracy and laid a foundation for further research into the influence of Kaplan turbine connecting to the grid.

  19. Analysing patient queue system in an imaging department: a step toward total quality management

    International Nuclear Information System (INIS)

    Kumar, Pratik; Pandey, A.K.

    2008-01-01

    Medical imaging has become an inevitable part of any diagnosis and/or management of the disease. This has put tremendous work-load on the medical imaging machines. The crowd of waiting patients at any busy imaging centre or rooms has become a common scene. This is especially true for any Government hospital or medical college in India since they cater to bulk of patients. As a part of total quality management we attempted to record, investigate, analyse and suggest on the state of patients' queue system at radiological imaging rooms

  20. Practical implementation of a quality management system in a radiological department; Praktische Umsetzung von Qualitaetsmanagement in einer radiologischen Abteilung

    Energy Technology Data Exchange (ETDEWEB)

    Huber, S.; Zech, C.J. [Klinikum der Ludwig-Maximilians-Universitaet, Campus Innenstadt, Institut fuer Klinische Radiologie, Muenchen (Germany)

    2011-10-15

    This article describes the architecture of a project aiming to implement a DIN EN ISO 9001 quality management system in a radiological department. It is intended to be a practical guide to demonstrate each step of the project leading to certification of the system. In a planning phase resources for the implementation of the project have to be identified and a quality management (QM) group as core team has to be formed. In the first project phase all available documents have to be checked and compiled in the QM manual. Moreover all relevant processes of the department have to be described in so-called process descriptions. In a second step responsibilities for the project are identified. Customer and employee surveys have to be carried out and a nonconformity management system has to be implemented. In this phase internal audits are also needed to check the new QM system, which is finally tested in the external certification audit with reference to its conformity with the standards. (orig.) [German] Dieser Beitrag beschreibt die Grundarchitektur einer Projektplanung fuer die Etablierung eines Qualitaetsmanagement(QM)-Systems mit Zertifizierung nach DIN EN ISO 9001 fuer eine radiologische Abteilung basierend auf eigenen Erfahrungen und der einschlaegigen Praxis. Er soll ein praktischer Leitfaden fuer die einzelnen Arbeitsschritte waehrend eines solchen Zertifizierungsprojekts sein. In einer Planungsphase muessen die erforderlichen Ressourcen fuer ein Zertifizierungsprojekt erfasst und eine QM-Gruppe als Kernteam gebildet werden. In der ersten Projektphase werden die Dokumente und Vorlagen der Abteilung gesichtet und in einem Handbuch gelenkt. Zudem muessen fuer alle wesentlichen Prozesse Beschreibungen erstellt werden. In einer zweiten Projektphase werden weitere Verantwortlichkeiten im Rahmen eines Beauftragtenwesens festgelegt, Befragungen relevanter ''Kunden'' (Patienten, Zuweiser) und Mitarbeiter durchgefuehrt und ein Fehler- und

  1. Design and Simulation of PID parameters self-tuning based on DC speed regulating system

    Directory of Open Access Journals (Sweden)

    Feng Wei Jie

    2016-01-01

    Full Text Available The DC speed regulating system has many difficult issues such as system parameters and PID control parameters are difficult to determine. On the basis of model for a single closed-loop DC speed regulating system, this paper puts forward a method of PID parameters self-tuning based on the step response detection and reduced order equivalent. First, detect system step response and get response parameters. Then equal it to a second order system model, and achieve optimal PID control parameters based on optimal second order system to realize of PID parameters self-tuning. The PID parameters self-tuning process of DC speed regulating system is simulated with the help of MATLAB/Simulink. The simulation results show that the method is simple and effective. The system can obtain good dynamic and static performance when the PID parameters are applied to DC speed regulating system.

  2. Quality assurance manual for the Department of Energy laboratory accreditation program for personnel dosimetry systems

    International Nuclear Information System (INIS)

    1987-02-01

    The overall purpose of this document is to establish a uniform approach to quality assurance. This will ensure that uniform, high-quality personnel dosimetry practices are followed by the participating testing laboratories. The document presents guidelines for calibrating and maintaining measurement and test equipment (M and TE), calibrating radiation fields, and subsequently irradiating and handling personnel dosimeters in laboratories involved in the DOE dosimetry systems testing program. Radiation energies for which the test procedures apply are photons with approximately 15 keV to 2 MeV, beta particles above 0.3 MeV, neutrons with approximately 1 keV to 2 MeV. 12 refs., 4 tabs

  3. New York City Police Department Automated Fuel Monitoring System. Volume II. Documentation Report.

    Science.gov (United States)

    1981-11-16

    toward solving troublesome problems. In addition, the private sector market has been stimulated to respond to system needs identified during the course of...8 -3Q .ifL I.N’ p uii3NLIE- __-U3 7/11 Ud-.i T01 LNI TERM ON-LN 151 071 328- ______ 33N.________ -~R~ NLINE 2141 53 07/11 16-ttl 145 INS TERM ON-LINE...4Z-46 131 LN4 TERM NLINE --3o56a 55 O7ALL-ZU _1 L. N ~Ii8ILON-~ik 1559 53 01/17 eZ-4.8 137 INN TERM4 ON-LINE " . " - 7 - M -1 ------------- - . 7 .Dm

  4. Regulation

    International Nuclear Information System (INIS)

    Ballereau, P.

    1999-01-01

    The different regulations relative to nuclear energy since the first of January 1999 are given here. Two points deserve to be noticed: the decree of the third august 1999 authorizing the national Agency for the radioactive waste management to install and exploit on the commune of Bures (Meuse) an underground laboratory destined to study the deep geological formations where could be stored the radioactive waste. The second point is about the uranium residues and the waste notion. The judgment of the administrative tribunal of Limoges ( 9. july 1998) forbidding the exploitation of a storage installation of depleted uranium considered as final waste and qualifying it as an industrial waste storage facility has been annulled bu the Court of Appeal. It stipulated that, according to the law number 75663 of the 15. july 1965, no criteria below can be applied to depleted uranium: production residue (possibility of an ulterior enrichment), abandonment of a personal property or simple intention to do it ( future use aimed in the authorization request made in the Prefecture). This judgment has devoted the primacy of the waste notion on this one of final waste. (N.C.)

  5. The Development of Innovation Systems as an Object with the State Regulation

    Directory of Open Access Journals (Sweden)

    Melnyk Alexander G.

    2017-09-01

    Full Text Available The article examines the processes of structuring the environment for the development of innovation systems in terms of the formation of a State regulated object. A methodological approach to definition of the State regulation at the primary, secondary and tertiary levels of structuring the environment of innovation systems has been suggested, based on the premise of the objective nature of the integration of social environment and market mechanisms into the structure of an object with the State regulation for the development of innovation systems. The definition of innovative systems as an object with the State regulation in terms of structural-organizational and functional areas of their expansion has been presented. A model for the progressive extension of the State regulated object by means of the development of innovation systems at the primary, secondary and tertiary levels of the structuring of environment in the process of formation of the institutional and technological structures of innovation systems has been proposed.

  6. 75 FR 41405 - Energy Priorities and Allocations System Regulations

    Science.gov (United States)

    2010-07-16

    ... information, including through the use of automated collection techniques or other forms of information... warehousing, ports, services, equipment and facilities, such as transportation carrier shop and repair... Department of Defense, use of petroleum and gas pipelines, and coal slurry pipelines used only to supply...

  7. Development of a novel information and communication technology system to compensate for a sudden shortage of emergency department physicians.

    Science.gov (United States)

    Tanaka, Kumiko; Nakada, Taka-Aki; Fukuma, Hiroshi; Nakao, Shota; Masunaga, Naohisa; Tomita, Keisuke; Matsumura, Yosuke; Mizushima, Yasuaki; Matsuoka, Tetsuya

    2017-01-23

    A sudden shortage of physician resources due to overwhelming patient needs can affect the quality of care in the emergency department (ED). Developing effective response strategies remains a challenging research area. We created a novel system using information and communication technology (ICT) to respond to a sudden shortage, and tested the system to determine whether it would compensate for a shortage. Patients (n = 4890) transferred to a level I trauma center in Japan during 2012-2015 were studied. We assessed whether the system secured the necessary physicians without using other means such as phone or pager, and calculated fulfillment rate by the system as a primary outcome variable. We tested for the difference in probability of multiple casualties among total casualties transferred to the ED as an indicator of ability to respond to excessive patient needs, in a secondary analysis before and after system introduction. The system was activated 24 times (stand-by request [n = 12], attendance request [n = 12]) in 24 months, and secured the necessary physicians without using other means; fulfillment rate was 100%. There was no significant difference in the probability of multiple casualties during daytime weekdays hours before and after system introduction, while the probability of multiple casualties during night or weekend hours after system introduction significantly increased compared to before system introduction (4.8% vs. 12.9%, P improvement in the ability to respond to sudden excessive patient needs in multiple causalities. A novel system using ICT successfully secured immediate responses from needed physicians outside the hospital without increasing user workload, and increased the ability to respond to excessive patient needs. The system appears to be able to compensate for a shortage of physician in the ED due to excessive patient transfers, particularly during off-hours.

  8. Normative Regulation of Anti-Corruption in the System of Local Self-Government

    Directory of Open Access Journals (Sweden)

    Darya F. Kupcha

    2017-03-01

    Full Text Available In the present work authors attempt to analyze normative acts aimed at regulating relations in the sphere of counteracting corruption at the level of local self-government. In the conclusion authors summarize that despite criticism, in the Russian Federation, a system of regulatory regulation to counteract corruption (including at the local level is formed. Further improvements of this system should be made in the legal regulation at the local level.

  9. System and method for regulating EGR cooling using a rankine cycle

    Science.gov (United States)

    Ernst, Timothy C.; Morris, Dave

    2015-12-22

    This disclosure relates to a waste heat recovery (WHR) system and method for regulating exhaust gas recirculation (EGR) cooling, and more particularly, to a Rankine cycle WHR system and method, including a recuperator bypass arrangement to regulate EGR exhaust gas cooling for engine efficiency improvement and thermal management. This disclosure describes other unique bypass arrangements for increased flexibility in the ability to regulate EGR exhaust gas cooling.

  10. Development of an electronic emergency department-based geo-information injury surveillance system in Hong Kong.

    Science.gov (United States)

    Chow, C B; Leung, M; Lai, Adela; Chow, Y H; Chung, Joanne; Tong, K M; Lit, Albert

    2012-06-01

    To describe the experience in the development of an electronic emergency department (ED)-based injury surveillance (IS) system in Hong Kong using data-mining and geo-spatial information technology (IT) for a Safe Community setup. This paper described the phased development of an emergency department-based IS system based on World Health Organization (WHO) injury surveillance Guideline to support safety promotion and injury prevention in a Safe Community in Hong Kong starting 2002. The initial ED data-based only collected data on name, sex, age, address, eight general categories of injury types (traffic, domestic, common assault, indecent assault, batter, industrial, self-harm and sports) and disposal from ED. Phase 1--manual data collection on International Classification of External Causes of Injury pre-event data; Phase 2--manual form was converted to electronic format using web-based data mining technology with built in data quality monitoring mechanism; Phase 3--integration of injury surveillance-data with in-patient hospital information; and Phase 4--geo-spatial information and body mapping were introduced to geo-code exact place of injury in an electronic map and site of injury on body map. It was feasible to develop a geo-spatial IS system at busy ED to collect valuable information for safety promotion and injury prevention at Safe Community setting. The keys for successful development and implementation involves engagement of all stakeholders at design and implementation of the system with injury prevention as ultimate goal, detail workflow planning at front end, support from the management, building on exiting system and appropriate utilisation of modern technology. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. Effect of an emergency department-based electronic system for musculoskeletal consultation on facilitating care for common injuries.

    Science.gov (United States)

    Mears, Simon C; Pantle, Hardin A; Bessman, Edward S; Lifchez, Scott D

    2015-05-01

    Access to musculoskeletal consultation in the emergency department (ED) is a nationwide problem. In addition, consultation from a subspecialist may be delayed or may not be available, which can slow down the ED flow and reduce patient satisfaction. The purpose of this study was to review the 1-year results of a change in the authors' institutional practice to reduce subspecialty consultation for select musculoskeletal problems while still ensuring adequate patient follow-up in orthopedic or plastic surgery clinics for patients not seen by these services in the ED. The authors hypothesized that select injuries could be safely managed in the ED by using an electronic system to ensure appropriate follow-up care. Using Kaizen methodology, a multidisciplinary group (including ED staff, orthopedics, plastic surgery, pediatrics, nursing, radiology, therapy, and administration) met to improve care for select musculoskeletal injuries. A system was agreed on in which ED providers managed select musculoskeletal injuries without subspecialist consultation. Follow-up was organized using an electronic system, which facilitated communication between the ED staff and the secretarial staff of the subspecialist departments. Over a 1-year period, 150 patients were treated using this system. Charts and radiographs were reviewed for missed injuries. Radiographic review revealed 2 missed injuries. One patient had additional back pain and a lumbar spine fracture was found during the subspecialist follow-up visit; it was treated nonoperatively. Another patient appeared to have scapholunate widening on the injury radiograph that was not appreciated in the ED. Of the 150 patients, 51 were seen in follow-up by a subspecialist at the authors' institution. An electronic system to organize follow-up with a subspecialist allowed the ED providers to deliver safe and effective care for simple musculoskeletal injuries. Copyright 2015, SLACK Incorporated.

  12. [Introduction of a quality management system compliant with DIN EN 9001:2000 in a university department of nuclear medicine].

    Science.gov (United States)

    Jansen-Schmidt, V; Paschen, U; Kröger, S; Bohuslavizki, K H; Clausen, M

    2001-12-01

    In 1995, the management of the University Clinic Hamburg-Eppendorf proposed to establish a total quality assurance (QA) system. A revised QA-system has been introduced stepwise in the department of nuclear medicine since 1997, and certification was achieved in accordance with DIN EN ISO 9001:2000 on February 14, 2001. The QA-handbook is divided into two parts. The first part contains operational (diagnostic and therapeutic) procedures in so-called standard operating procedures (SOP). They describe the indication of procedures as well as the competences and time necessary in a standardized manner. Up to now, more than 70 SOPs have been written as a collaborative approach between technicians and physicians during daily clinical routine after analysing and discussing the procedures. Thus, the results were more clearly defined processes and more satisfied employees. The second part consists of general rules and directions concerning the security of work and equipment as well as radiation protection tasks, hygiene etc. as it is required by the law. This part was written predominantly by the management of the department of nuclear-medicine and the QA-coordinator. Detailed information for the patients, documentation of the work-flows as well as the medical report was adopted to the QM-system. Although in the introduction phase of a QA-system a vast amount of time is necessary, some months later a surplus for the clinical workday will become available. The well defined relations of competences and procedures will result in a gain of time, a reduction of costs and a help to ensure the legal demands. Last but not least, the QA-system simply helps to build up confidence and acceptance both by the patients and the referring physicians.

  13. Metallurgy Department

    DEFF Research Database (Denmark)

    Risø National Laboratory, Roskilde

    The activities of the Metallurgy Department at Risø during 1981 are described. The work is presented in three chapters: General Materials Research, Technology and Materials Development, Fuel Elements. Furthermore, a survey is given of the department's participation in international collaboration...

  14. DC microgrids with energy storage systems and demand response for providing support to frequency regulation of electrical power systems

    DEFF Research Database (Denmark)

    Basic, Hrvoje; Dragicevic, Tomislav; Pandzic, Hrvoje

    2017-01-01

    Frequency regulation of electric power systems efficiency depends on response time and on power reserves for frequency regulation. As integration of non-dispatchable renewable generation in the power system results with increased need for power reserves from fast responding power units, the idea ...

  15. The NAD/NARB System: Advertising Self-Regulation at Work.

    Science.gov (United States)

    Hays, Robert

    Self-regulation, as defined by the National Advertising Division/National Advertising Review Board (NAD/NARB), is a process whereby the advertising industry regulates itself and turns to the federal government only if the system fails. The NAD/NARB system involves a two-step process: complaints are initially handled by the NAD and then are either…

  16. 75 FR 3178 - Defense Federal Acquisition Regulation Supplement; Lead System Integrators

    Science.gov (United States)

    2010-01-20

    ... Government procurement. Amy G. Williams, Editor, Defense Acquisition Regulations System. 0 Accordingly, the..., without change, an interim rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to... limitations on the award of new contracts for lead system integrator functions in the acquisition of major DoD...

  17. A task-based support architecture for developing point-of-care clinical decision support systems for the emergency department.

    Science.gov (United States)

    Wilk, S; Michalowski, W; O'Sullivan, D; Farion, K; Sayyad-Shirabad, J; Kuziemsky, C; Kukawka, B

    2013-01-01

    The purpose of this study was to create a task-based support architecture for developing clinical decision support systems (CDSSs) that assist physicians in making decisions at the point-of-care in the emergency department (ED). The backbone of the proposed architecture was established by a task-based emergency workflow model for a patient-physician encounter. The architecture was designed according to an agent-oriented paradigm. Specifically, we used the O-MaSE (Organization-based Multi-agent System Engineering) method that allows for iterative translation of functional requirements into architectural components (e.g., agents). The agent-oriented paradigm was extended with ontology-driven design to implement ontological models representing knowledge required by specific agents to operate. The task-based architecture allows for the creation of a CDSS that is aligned with the task-based emergency workflow model. It facilitates decoupling of executable components (agents) from embedded domain knowledge (ontological models), thus supporting their interoperability, sharing, and reuse. The generic architecture was implemented as a pilot system, MET3-AE--a CDSS to help with the management of pediatric asthma exacerbation in the ED. The system was evaluated in a hospital ED. The architecture allows for the creation of a CDSS that integrates support for all tasks from the task-based emergency workflow model, and interacts with hospital information systems. Proposed architecture also allows for reusing and sharing system components and knowledge across disease-specific CDSSs.

  18. [The experience of implementation of system of quality management in the Department of Laboratory Diagnostic of the N.V. Sklifosofskiy Research Institute of Emergency Care of Moscow Health Department: a lecture].

    Science.gov (United States)

    Zenina, L P; Godkov, M A

    2013-08-01

    The article presents the experience of implementation of system of quality management into the practice of multi-field laboratory of emergency medical care hospital. The analysis of laboratory errors is applied and the modes of their prevention are demonstrated. The ratings of department of laboratory diagnostic of the N. V. Sklifosofskiy research institute of emergency care in the program EQAS (USA) Monthly Clinical Chemistry from 2007 are presented. The implementation of the system of quality management of laboratory analysis into department of laboratory diagnostic made it possible to support physicians of clinical departments with reliable information. The confidence of clinicians to received results increased. The effectiveness of laboratory diagnostic increased due to lowering costs of analysis without negative impact to quality of curative process.

  19. Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

    OpenAIRE

    Kleinridders, Andr?; Ferris, Heather A.; Cai, Weikang; Kahn, C. Ronald

    2014-01-01

    Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of appetite, reproductive function, body temperature, white fat mass, hepatic glucose output, and response to hypoglycemia. Insulin signaling also modulates neurotransmitter channel activity, brain cholesterol synthesis, and mitochondrial function. Disruption of insulin action in t...

  20. 75 FR 64148 - General Regulation: National Park System

    Science.gov (United States)

    2010-10-19

    ... literary giant at the Eugene O'Neill National Historical Site, California; and the artistic grace of a... that is not reasonably likely to attract a crowd or onlookers. This language is similar to the... the criteria of section 3(b)(2) requiring that all regulations be written in clear language and...

  1. Voltage regulator placement in radial distribution system using plant ...

    African Journals Online (AJOL)

    user

    location and number along with tap setting of the voltage regulators that ... can be fixed or switched type; they are considered integer multiple of a capacitor unit ..... By simulating the growth process of plant phototropism, a probability model ..... He is referee for IEE Proceedings - Generation Transmission and Distribution and ...

  2. The Kdp-ATPase system and its regulation

    Indian Academy of Sciences (India)

    2007-03-15

    Mar 15, 2007 ... K+, the dominant intracellular cation, is required for various physiological processes like turgor homeostasis, pH regulation etc. Bacterial cells have evolved many diverse K+ transporters to maintain the desired concentration of internal K+. In E. coli, the KdpATPase (comprising of the KdpFABC complex), ...

  3. Analysis of health impact inputs to the US Department of Energy's risk information system

    Energy Technology Data Exchange (ETDEWEB)

    Droppo, J.G. Jr.; Buck, J.W.; Strenge, D.L.; Siegel, M.R.

    1990-08-01

    The US Department of Energy (DOE) is in the process of completing a survey of environmental problems, referred to as the Environmental Survey, at their facilities across the country. The DOE Risk Information System (RIS) is being used to prioritize these environmental problems identified in the Environmental Survey's findings. This report contains a discussion of site-specific public health risk parameters and the rationale for their inclusion in the RIS. These parameters are based on computed potential impacts obtained with the Multimedia Environmental Pollutant Assessment System (MEPAS). MEPAS is a computer-based methodology for evaluating the potential exposures resulting from multimedia environmental transport of hazardous materials. This report has three related objectives: document the role of MEPAS in the RIS framework, report the results of the analysis of alternative risk parameters that led to the current RIS risk parameters, and describe analysis of uncertainties in the risk-related parameters. 20 refs., 17 figs., 10 tabs.

  4. Development of an electronic medical report delivery system to 3G GSM mobile (cellular) phones for a medical imaging department.

    Science.gov (United States)

    Lim, Eugene Y; Lee, Chiang; Cai, Weidong; Feng, Dagan; Fulham, Michael

    2007-01-01

    Medical practice is characterized by a high degree of heterogeneity in collaborative and cooperative patient care. Fast and effective communication between medical practitioners can improve patient care. In medical imaging, the fast delivery of medical reports to referring medical practitioners is a major component of cooperative patient care. Recently, mobile phones have been actively deployed in telemedicine applications. The mobile phone is an ideal medium to achieve faster delivery of reports to the referring medical practitioners. In this study, we developed an electronic medical report delivery system from a medical imaging department to the mobile phones of the referring doctors. The system extracts a text summary of medical report and a screen capture of diagnostic medical image in JPEG format, which are transmitted to 3G GSM mobile phones.

  5. Conceptual design of control rod regulating system for plate type fuels of Triga-2000 reactor

    International Nuclear Information System (INIS)

    Eko Priyono; Saminto

    2016-01-01

    Conceptual design of the control rod regulating system for plate type fuel of TRIGA-2000 reactor has been made. Conceptual design of the control rod regulating system for plate type fuel of TRIGA-2000 reactor was made with refer to study result of instrument and control system which is used in BATAN'S reactor. Conceptual design of the control rod regulating system for plate type fuel of TRIGA-2000 reactor consist of 4 segments that is control panel, translator, driver and display. Control panel is used for regulating, safety and display control rod, translator is used for signal processing from control panel, driver is used for driving control rod and display is used for display control rod level position. The translator was designed in 2 modes operation i.e operation by using PLC modules and IC TTL modules. These conceptual design can be used as one of reference of control rod regulating system detail design. (author)

  6. R and D perspectives on the advanced nuclear safety regulation system

    International Nuclear Information System (INIS)

    Lee, Chang Ju; Ahn, Sang Kyu; Park, Jong Seuk; Chung, Dae Wook; Han, Sang Hoon; Lee, Jung Won

    2009-01-01

    As current licensing process is much desired to be optimized both plant safety and regulatory efficiency, an advanced safety regulation such as risk informed regulation has been come out. Also, there is a need to have a future oriented safety regulation since a lot of new reactors are conceptualized. Keeping pace with these needs, since early 2007, Korean government has launched a new project for preparing an advanced and future oriented nuclear safety regulation system. In order to get practical achievements, the project team sets up such specific research objectives for the development of: implementation program for graded regulation using risk and performance information; multi purpose PSA models for regulatory uses; a technology neutral regulatory framework for future innovative reactors; evaluation procedure of proliferation resistance; and, performance based fire hazard analysis method and evaluation system. This paper introduces major R and D outputs of this project, and provides some perspectives for achieving effectiveness and efficiency of the nuclear regulation system in Korea

  7. R and D perspectives on the advanced nuclear safety regulation system

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Ju; Ahn, Sang Kyu; Park, Jong Seuk; Chung, Dae Wook [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of); Han, Sang Hoon; Lee, Jung Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2009-04-15

    As current licensing process is much desired to be optimized both plant safety and regulatory efficiency, an advanced safety regulation such as risk informed regulation has been come out. Also, there is a need to have a future oriented safety regulation since a lot of new reactors are conceptualized. Keeping pace with these needs, since early 2007, Korean government has launched a new project for preparing an advanced and future oriented nuclear safety regulation system. In order to get practical achievements, the project team sets up such specific research objectives for the development of: implementation program for graded regulation using risk and performance information; multi purpose PSA models for regulatory uses; a technology neutral regulatory framework for future innovative reactors; evaluation procedure of proliferation resistance; and, performance based fire hazard analysis method and evaluation system. This paper introduces major R and D outputs of this project, and provides some perspectives for achieving effectiveness and efficiency of the nuclear regulation system in Korea.

  8. Regulation of the galanin system by repeated electroconvulsive seizures in mice

    DEFF Research Database (Denmark)

    Christiansen, S H; Woldbye, D P D

    2010-01-01

    of epileptic activity and depression, including the piriform cortex, hippocampal dentate gyrus, and amygdala. Likewise, GalR2 gene expression was up-regulated in both the central and the medial amygdala, whereas GalR1 gene expression showed a modest down-regulation in the medial amygdala. [(125) I......]galanin receptor binding in the piriform cortex, hippocampus, and amygdala was found to be significantly down-regulated. These data show that the galanin system is regulated by repeated ECS in a number of brain regions implicated in seizure regulation and depression. These changes may play a role...

  9. Department of Energy (DOE) transportation system for nuclear materials and the role of state law enforcement agencies

    International Nuclear Information System (INIS)

    Jones, J.M.; Hoover, T.W.

    1978-01-01

    The Department of Energy has been assigned the responsibility for the safe and secure movement of strategic quantities of government-owned special nuclear material as well as classified material. To accomplish this mission, a transportation system has been developed which takes advantage of advanced technology and other features to reduce vulnerability to terrorists. The system consists of a careful balance of specially-trained personnel, procedures and sophisticated equipment. These, in combination, generally allow the system to be self-sufficient. However, should the need arise, DOE will request assistance from state law enforcement agencies. The primary contact for assistance is the state police or highway patrol. DOE, with the assistance of Sandia Laboratories, has surveyed state police agencies throughout the nation. A data base has been created which includes the results of these surveys and a numerical description of DOE transportation routes. This data base, along with a ''Response'' model developed by Sandia Laboratories, allows projections of officer availability to be made for all of DOE's routes. This paper will describe the DOE Transportation System, the role of state law enforcement agencies in support of the system, the nationwide state policy survey, and the operation of the response computer model

  10. Leptin regulates bone formation via the sympathetic nervous system

    Science.gov (United States)

    Takeda, Shu; Elefteriou, Florent; Levasseur, Regis; Liu, Xiuyun; Zhao, Liping; Parker, Keith L.; Armstrong, Dawna; Ducy, Patricia; Karsenty, Gerard

    2002-01-01

    We previously showed that leptin inhibits bone formation by an undefined mechanism. Here, we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks differ, and that the peripheral mediators of leptin antiosteogenic function appear to be neuronal. Neuropeptides mediating leptin anorexigenic function do not affect bone formation. Leptin deficiency results in low sympathetic tone, and genetic or pharmacological ablation of adrenergic signaling leads to a leptin-resistant high bone mass. beta-adrenergic receptors on osteoblasts regulate their proliferation, and a beta-adrenergic agonist decreases bone mass in leptin-deficient and wild-type mice while a beta-adrenergic antagonist increases bone mass in wild-type and ovariectomized mice. None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis.

  11. Intelligent energy systems - Regulating the electricity grid using car batteries

    International Nuclear Information System (INIS)

    Horbaty, R.

    2009-01-01

    This article takes a look at how the electricity supply industry will, in the future, be able to substantially rely on decentrally organised sources of renewable energy. As such forms of power generation are, in part, difficult to plan, the increasing importance of regulating energy is being stressed. The use of the batteries of plug-in hybrid vehicles to provide such regulating power is discussed. So-called smart grids within the framework of a deregulated energy market are discussed and examples of possible configurations are noted. The intelligent control of apparatus and generation and storage facilities is discussed. Individual mobility with lower emissions is examined. New business areas now opening up for the electricity economy and vehicle manufacturers are discussed.

  12. Cholesterol: Its Regulation and Role in Central Nervous System Disorders

    OpenAIRE

    Matthias Orth; Stefano Bellosta

    2012-01-01

    Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol-rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain. Cholesterol is tightly regulated between the major brain cells and is essential for normal brain development. The metabolism of brain cholesterol differs markedly from that of other tissues. Brain cholesterol is primarily derived by de novo synthesis and the blood brain barrier prevents the uptake of lipoprotein...

  13. Using an Emergency Department Syndromic Surveillance System to Evaluate Reporting of Potential Rabies Exposures, Illinois, 2013-2015.

    Science.gov (United States)

    Bemis, Kelley; Frias, Mabel; Patel, Megan Toth; Christiansen, Demian

    Mandatory reporting of potential rabies exposures and initiation of postexposure prophylaxis (PEP) allow local health authorities to monitor PEP administration for errors. Our objectives were to use an emergency department (ED) syndromic surveillance system to (1) estimate reporting compliance for exposure to rabies in suburban Cook County, Illinois, and (2) initiate interventions to improve reporting and reassess compliance. We queried ED records from 45 acute care hospitals in Cook County and surrounding areas from January 1, 2013, through June 30, 2015, for chief complaints or discharge diagnoses pertaining to rabies, PEP, or contact with a wild mammal (eg, bat, raccoon, skunk, fox, or coyote). We matched patients with ≥1 ED visit for potential rabies exposure to people with potential rabies exposure reported to the Cook County Department of Public Health. We considered nonmatches to have unreported exposures. We then initiated active surveillance in July 2015, disseminated education on reporting requirements in August and September 2015, and reassessed reporting completeness from July 2015 through February 2016. Of 248 patients with rabies-related ED visits from January 2013 through June 2015, 63 (25.4%) were reported. After interventions were implemented to increase reporting compliance, 53 of 98 (54.1%) patients with rabies-related ED visits from July 2015 through February 2016 were reported. Patients with ED visits for potential rabies exposure were twice as likely to be reported postintervention than preintervention (risk ratio = 2.1; 95% CI, 1.6-2.8). The volume of potential rabies exposure cases reported to the health department from July 2015 through February 2016 increased by 252% versus the previous year. Potential rabies exposures and PEP initiation are underreported in suburban Cook County. ED syndromic surveillance records can be used to estimate reporting compliance and conduct active surveillance.

  14. Treatment of uncertainty in the US department of energy's yucca mountain repository total system performance assessment (TSPA)

    International Nuclear Information System (INIS)

    Van Luik, A.; Zwahlen, E.

    2004-01-01

    The regulatory requirements being addressed in the US geological repository programme for spent nuclear fuel and high-level waste specify that performance assessment is to be used to address probabilistically defined mean-value dose constraints. Dose was chosen as the preferred performance measure because an acceptable dose limit could be selected through the regulation-setting process, based on a defined acceptable risk. By setting a dose limit, arguments about the conversion of a potential dose to a potential risk was taken off the table as a potential licensing issue. However, the probabilistic approach called for actually delivers a 'risk of a dose', a risk of a potential given dose value to a hypothetical person living at a set distance from the repository, with a set lifestyle, between the time of permanent closure and 10 000 years. Analyses must also be shown for the peak dose if it occurs after 10 000 years, essentially to a million years. For uncertain parameters that are important to system performance, the goal is to present an analysis that, in accord with applicable regulation, focuses on the mean value of the performance measure but also explores the 'full range of defensible and reasonable parameter distributions'.... System performance evaluations should not be unduly influenced by... 'extreme physical situations and parameter values'. These disclosure requirements are to be met by showing a range of potential outcomes and designating the mean value within that range. (author)

  15. A two-component system regulates hemin acquisition in Porphyromonas gingivalis.

    Directory of Open Access Journals (Sweden)

    Jodie C Scott

    Full Text Available Porphyromonas gingivalis is a Gram-negative oral anaerobe associated with infection of the periodontia. The organism has a small number of two-component signal transduction systems, and after comparing genome sequences of strains W83 and ATCC 33277 we discovered that the latter was mutant in histidine kinase (PGN_0752, while the cognate response regulator (PGN_0753 remained intact. Microarray-based transcriptional profiling and ChIP-seq assays were carried out with an ATCC 33277 transconjugant containing the functional histidine kinase from strain W83 (PG0719. The data showed that the regulon of this signal transduction system contained genes that were involved in hemin acquisition, including gingipains, at least three transport systems, as well as being self-regulated. Direct regulation by the response regulator was confirmed by electrophoretic mobility shift assays. In addition, the system appears to be activated by hemin and the regulator acts as both an activator and repressor.

  16. [Evaluation of the performance of the logistics management system of malaria control resources in the Littoral Department, Benin, in 2017].

    Science.gov (United States)

    Ouro-Koura, Abdou-Rahim; Sopoh, Emmanuel Ghislain; Sossa, Jerôme Charles; Glèlè-Ahanhanzo, Yolaine; Agueh, Victoire; Ouendo, Edgard-Marius; Ouedraogo, Laurent

    2018-01-01

    This study aimed to evaluate the performance of the logistics management system (LMS) of malaria control (MC) resources in the Littoral Department, Benin, in 2017. In June 2017, we conducted a cross-sectional evaluative study focusing on the structures for the storage and the disposal of MC resources as well as on staff involved in their management. The performance of the the logistics management system was evaluated on the basis of the observed compliance of the components and sub-components of the "Structure", the "Process" and the "Results" with the norms and standards defined by the Ministry of Health. A total of 36 structures were investigated and secondary target was surveyed. It followed that 52,78% of the structures for the storage and the disposal of MC resources met the requirements for resources storage while only 33.33% of MC resources management staff were trained in logistics management. The performance of the logistics management system of MC resources was inadequate (compliance 59,13 % compared to the expected score). The structure, as well as the process were non-compliant with the standards ( 60,20% and 73.22% compared to the expected score respectively), leading to negative results (41.53% compared to the expected score). The most inadequate sub-component was the logistics management information system (LMIS). This study highlights the role of LMS for better performance of MC resources management. Particular attention should be given to this component.

  17. Contact tracing with a real-time location system: A case study of increasing relative effectiveness in an emergency department.

    Science.gov (United States)

    Hellmich, Thomas R; Clements, Casey M; El-Sherif, Nibras; Pasupathy, Kalyan S; Nestler, David M; Boggust, Andy; Ernste, Vickie K; Marisamy, Gomathi; Koenig, Kyle R; Hallbeck, M Susan

    2017-12-01

    Contact tracing is the systematic method of identifying individuals potentially exposed to infectious diseases. Electronic medical record (EMR) use for contact tracing is time-consuming and may miss exposed individuals. Real-time location systems (RTLSs) may improve contact identification. Therefore, the relative effectiveness of these 2 contact tracing methodologies were evaluated. During a pertussis outbreak in the United States, a retrospective case study was conducted between June 14 and August 31, 2016, to identify the contacts of confirmed pertussis cases, using EMR and RTLS data in the emergency department of a tertiary care medical center. Descriptive statistics and a paired t test (α = 0.05) were performed to compare contacts identified by EMR versus RTLS, as was correlation between pertussis patient length of stay and the number of potential contacts. Nine cases of pertussis presented to the emergency department during the identified time period. RTLS doubled the potential exposure list (P < .01). Length of stay had significant positive correlation with contacts identified by RTLS (ρ = 0.79; P = .01) but not with EMR (ρ = 0.43; P = .25). RTLS doubled the potential pertussis exposures beyond EMR-based contact identification. Thus, RTLS may be a valuable addition to the practice of contact tracing and infectious disease monitoring. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  18. Applying the Lean principles of the Toyota Production System to reduce wait times in the emergency department.

    Science.gov (United States)

    Ng, David; Vail, Gord; Thomas, Sophia; Schmidt, Nicki

    2010-01-01

    In recognition of patient wait times, and deteriorating patient and staff satisfaction, we set out to improve these measures in our emergency department (ED) without adding any new funding or beds. In 2005 all staff in the ED at Hôtel-Dieu Grace Hospital began a transformation, employing Toyota Lean manufacturing principles to improve ED wait times and quality of care. Lean techniques such as value-stream mapping, just-in-time delivery techniques, workplace organization, reduction of systemic wastes, use of the worker as the source of quality improvement and ongoing refinement of our process steps formed the basis of our project. Our ED has achieved major improvements in departmental flow without adding any additional ED or inpatient beds. The mean registration to physician time has decreased from 111 minutes to 78 minutes. The number of patients who left without being seen has decreased from 7.1% to 4.3%. The length of stay (LOS) for discharged patients has decreased from a mean of 3.6 to 2.8 hours, with the largest decrease seen in our patients triaged at levels 4 or 5 using the Canadian Emergency Department Triage and Acuity Scale. We noted an improvement in ED patient satisfaction scores following the implementation of Lean principles. Lean manufacturing principles can improve the flow of patients through the ED, resulting in greater patient satisfaction along with reduced time spent by the patient in the ED.

  19. 48 CFR 22.1015 - Discovery of errors by the Department of Labor.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Discovery of errors by the... REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22.1015 Discovery of errors by the Department of Labor. If the Department of...

  20. 48 CFR 53.303-DD-441 - Department of Defense DD Form 441, Security Agreement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Department of Defense DD Form 441, Security Agreement. 53.303-DD-441 Section 53.303-DD-441 Federal Acquisition Regulations...-DD-441 Department of Defense DD Form 441, Security Agreement. EC01MY91.163 EC01MY91.164 ...

  1. Internal Controls and Compliance With Laws and Regulations for the FY 1996 Financial Statements of the "Other Defense Organizations" Receiving Department 97 Appropriations

    National Research Council Canada - National Science Library

    1997-01-01

    The overall audit objective was to assess internal controls and compliance with laws and regulations and to review and evaluate the adjustments to the FY 1996 "Other Defense Organizations" financial statements...

  2. An advanced regulator for the helium pressurization systems of the Space Shuttle OMS and RCS

    Science.gov (United States)

    Wichmann, H.

    1973-01-01

    The Space Shuttle Orbit Maneuvering System and Reaction Control System are pressure-fed rocket propulsion systems utilizing earth storable hypergolic propellants and featuring engines of 6000 lbs and 900 lbs thrust, respectively. The helium pressurization system requirements for these propulsion systems are defined and the current baseline pressurization systems are described. An advanced helium pressure regulator capable of meeting both OMS and RCS helium pressurization system requirements is presented and its operating characteristics and predicted performance characteristics are discussed.

  3. Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells

    OpenAIRE

    Worthington, John J.; Fenton, Thomas M.; Czajkowska, Beata I.; Klementowicz, Joanna E.; Travis, Mark A.

    2012-01-01

    Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell?cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-? (TGF-?). TGF-? is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells ...

  4. Controlling chaotic and hyperchaotic systems via energy regulation

    International Nuclear Information System (INIS)

    Laval, L.; M'Sirdi, N.K.

    2003-01-01

    This paper focuses on a new control approach to steer trajectories of chaotic or hyperchaotic systems towards stable periodic orbits or stationary points of interest. This approach mainly consists in a variable structure control (VSC) that we extend by explicitly considering the system energy as basis for both controller design and system stabilization. In this paper, we present some theoretical results for a class of nonlinear (possibly chaotic or hyperchaotic) systems. Then some capabilities of the proposed approach are illustrated through examples related to a four-dimensional hyperchaotic system

  5. Child Maltreatment and Neural Systems Underlying Emotion Regulation.

    Science.gov (United States)

    McLaughlin, Katie A; Peverill, Matthew; Gold, Andrea L; Alves, Sonia; Sheridan, Margaret A

    2015-09-01

    The strong associations between child maltreatment and psychopathology have generated interest in identifying neurodevelopmental processes that are disrupted following maltreatment. Previous research has focused largely on neural response to negative facial emotion. We determined whether child maltreatment was associated with neural responses during passive viewing of negative and positive emotional stimuli and effortful attempts to regulate emotional responses. A total of 42 adolescents aged 13 to 19 years, half with exposure to physical and/or sexual abuse, participated. Blood oxygen level-dependent (BOLD) response was measured during passive viewing of negative and positive emotional stimuli and attempts to modulate emotional responses using cognitive reappraisal. Maltreated adolescents exhibited heightened response in multiple nodes of the salience network, including amygdala, putamen, and anterior insula, to negative relative to neutral stimuli. During attempts to decrease responses to negative stimuli relative to passive viewing, maltreatment was associated with greater recruitment of superior frontal gyrus, dorsal anterior cingulate cortex, and frontal pole; adolescents with and without maltreatment down-regulated amygdala response to a similar degree. No associations were observed between maltreatment and neural response to positive emotional stimuli during passive viewing or effortful regulation. Child maltreatment heightens the salience of negative emotional stimuli. Although maltreated adolescents modulate amygdala responses to negative cues to a degree similar to that of non-maltreated youths, they use regions involved in effortful control to a greater degree to do so, potentially because greater effort is required to modulate heightened amygdala responses. These findings are promising, given the centrality of cognitive restructuring in trauma-focused treatments for children. Copyright © 2015 American Academy of Child and Adolescent Psychiatry

  6. The Department of Energy's Remedial Action Assessment System (RAAS): Decision support tools for performing streamlined feasibility studies

    International Nuclear Information System (INIS)

    White, M.K.

    1994-06-01

    The United States Department of Energy (DOE) faces the major task of cleaning up hundreds of waste sites across the nation, which will require completion of a large number of remedial investigation/feasibility studies (RI/FSs). The intent of each RI/FS is to characterize the waste problems and environmental conditions at the operable unit level, segment the remediation problem into manageable medium-specific and contaminant-specific pieces, define corresponding remediation objectives, and identify remedial response actions to satisfy those objectives. The RI/FS team can then identify combinations of remediation technologies that will meet the remediation objectives. Finally, the team must evaluate these remedial alternatives in terms of effectiveness, implementability, cost, and acceptability. The Remedial Action Assessment System (RAAS) is being developed by Pacific Northwest Laboratory (PNL) to support DOE in this effort

  7. An Adaptive Regulator for Space Teleoperation System in Task Space

    Directory of Open Access Journals (Sweden)

    Chao Ge

    2014-01-01

    Full Text Available The problem of the gravity information which can not be obtained in advance for bilateral teleoperation is studied. In outer space exploration, the gravity term changes with the position changing of the slave manipulator. So it is necessary to design an adaptive regulator controller to compensate for the unknown gravity signal. Moreover, to get a more accurate position tracking performance, the controller is designed in the task space instead of the joint space. Additionally, the time delay considered in this paper is not only time varying but also unsymmetrical. Finally, simulations are presented to show the effectiveness of the proposed approach.

  8. 21 CFR 866.5900 - Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation detection system.

    Science.gov (United States)

    2010-04-01

    ... regulator (CFTR) gene mutation detection system. 866.5900 Section 866.5900 Food and Drugs FOOD AND DRUG...) gene mutation detection system. (a) Identification. The CFTR gene mutation detection system is a device... Guidance Document: CFTR Gene Mutation Detection System.” See § 866.1(e) for the availability of this...

  9. 75 FR 6669 - Federal Acquisition Regulation; Submission for OMB Review; Contractors' Purchasing Systems Reviews

    Science.gov (United States)

    2010-02-10

    ...' Purchasing Systems Reviews AGENCIES: Department of Defense (DOD), General Services Administration (GSA), and... collection requirement concerning contractors' purchasing systems reviews. A request for public comments was..., Washington, DC 20405. Please cite OMB Control No. 9000-0132, Contractors' Purchasing Systems Review, in all...

  10. System-Level Process Change Improves Communication and Follow-Up for Emergency Department Patients With Incidental Radiology Findings.

    Science.gov (United States)

    Baccei, Steven J; Chinai, Sneha A; Reznek, Martin; Henderson, Scott; Reynolds, Kevin; Brush, D Eric

    2018-04-01

    The appropriate communication and management of incidental findings on emergency department (ED) radiology studies is an important component of patient safety. Guidelines have been issued by the ACR and other medical associations that best define incidental findings across various modalities and imaging studies. However, there are few examples of health care facilities designing ways to manage incidental findings. Our institution aimed to improve communication and follow-up of incidental radiology findings in ED patients through the collaborative development and implementation of system-level process changes including a standardized loop-closure method. We assembled a multidisciplinary team to address the nature of these incidental findings and designed new workflows and operational pathways for both radiology and ED staff to properly communicate incidental findings. Our results are based on all incidental findings received and acknowledged between November 1, 2016, and May 30, 2017. The total number of incidental findings discovered was 1,409. Our systematic compliance fluctuated between 45% and 95% initially after implementation. However, after overcoming various challenges through optimization, our system reached a compliance rate of 93% to 95%. Through the implementation of our new, standardized communication system, a high degree of compliance with loop closure for ED incidental radiology findings was achieved at our institution. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  11. Robust Fuzzy Control for Fractional-Order Uncertain Hydroturbine Regulating System with Random Disturbances

    Directory of Open Access Journals (Sweden)

    Fengjiao Wu

    2016-01-01

    Full Text Available The robust fuzzy control for fractional-order hydroturbine regulating system is studied in this paper. First, the more practical fractional-order hydroturbine regulating system with uncertain parameters and random disturbances is presented. Then, on the basis of interval matrix theory and fractional-order stability theorem, a fuzzy control method is proposed for fractional-order hydroturbine regulating system, and the stability condition is expressed as a group of linear matrix inequalities. Furthermore, the proposed method has good robustness which can process external random disturbances and uncertain parameters. Finally, the validity and superiority are proved by the numerical simulations.

  12. Safety regulations concerning instrumentation and control systems for research reactors

    International Nuclear Information System (INIS)

    El-Shanshoury, A.I.

    2009-01-01

    A brief study on the safety and reliability issues related to instrumentation and control systems in nuclear reactor plants is performed. In response, technical and strategic issues are used to accomplish instrumentation and control systems safety. For technical issues there are ; systems aspects of digital I and C technology, software quality assurance, common-mode software, failure potential, safety and reliability assessment methods, and human factors and human machine interfaces. The strategic issues are the case-by-case licensing process and the adequacy of the technical infrastructure. The purpose of this work was to review the reliability of the safety systems related to these technical issues for research reactors

  13. Prospects for regulated competition in the health care system: what can China learn from Russia's experience?

    Science.gov (United States)

    Xu, Weiwei; Sheiman, Igor; van de Ven, Wynand P M M; Zhang, Wei

    2011-05-01

    As China explores new directions to reform its health care system, regulated competition among both insurers and providers of care might be one potential model. The Russian Federation in 1993 implemented legislation intended to stimulate such regulated competition in the health care sector. The subsequent progress and lessons learned over these 17 years can shed light on and inform the future evolution of the Chinese system. In this paper, we list the necessary pre-conditions for reaping the benefits of regulated competition in the health care sector. We indicate to what extent these conditions are being fulfilled in the post-reform Russian and current Chinese health care systems. We draw lessons from the Russian experience for the Chinese health care system, which shares a similar economic and political background with the pre-reform Russian health care system in terms of the starting point of the reform, and analyse the prospects for regulated competition in China.

  14. Fuzzy Controller for a Voltage-Regulated Solar-Powered MPPT System for Hybrid Power System Applications

    Directory of Open Access Journals (Sweden)

    Jaw-Kuen Shiau

    2015-04-01

    Full Text Available This paper presents the design of a fuzzy-logic-based voltage-regulated solar power maximum power point tracking (MPPT system for applications involving hybrid power systems. The system contains a solar power system and battery as the primary and secondary power sources, respectively. The solar system alone supplies power to the electric motor and maintains the output voltage at a predetermined level when it has sufficient power. When the solar power is insufficient, the solar system is operated at its maximum power point (MPP and the battery is engaged to compensate for the insufficiency. First, a variant of the incremental conductance MPP condition was established. Under the MPP condition, the voltage-regulated MPPT system was formulated as a feedback control system, where the MPP condition and voltage regulation requirements were used as the system inputs. Next, a fuzzy controller was developed to perform the voltage-regulated MPPT function for the hybrid power system. A simulation model based on Matrix laboratory (MATLAB/SIMULINK (a block diagram environment for multi-domain simulation and model-based design and a piecewise linear electric circuit simulation (PLECS tool for controlling the dc motor velocity was developed to verify the voltage-regulated solar power MPPT system.

  15. Developing a system to predict laboratory-confirmed chlamydial and/or gonococcal urethritis in adult male emergency department patients.

    Science.gov (United States)

    Merchant, Roland C; DePalo, Dina M; Liu, Tao; Rich, Josiah D; Stein, Michael D

    2010-01-01

    We aimed to create a system for predicting which male emergency department (ED) patients with suspected chlamydial and/or gonococcal urethritis would have laboratory-confirmed infections based on clinical factors available at the initial ED encounter. We used statistical models to develop a system to predict either the presence or absence of laboratory-confirmed chlamydial and/or gonorrheal urethritis based on patient demographics and presenting symptoms. Data for the system were extracted from a retrospective chart review of adult male patients who were suspected of having, and were tested for, chlamydial and/or gonococcal urethritis at an adult, urban, northeastern United States, academic ED from January 1998 to December 2004. Among the 822 patients tested, 29.2% had chlamydia, gonorrhea, or both infections; 13.8% were infected with chlamydia alone, 12.1% were infected with gonorrhea alone, and 3.3% were infected with both. From the statistical models, the following factors were predictive of a positive laboratory test for chlamydia and/or gonorrhea: age urethritis, paired with baseline ED prevalence of these infections, was confirmed through internal validation testing to modestly predict which patients had or did not have a laboratory-confirmed infection. This system of a combination of risk factors available during the clinical encounter in the ED modestly predicts which adult male patients suspected of having chlamydial and/or gonorrheal urethritis are more likely to have or not have a laboratory-confirmed infection. A prospective study is needed to create and validate a clinical prediction rule based on the results of this system.

  16. Implementing a Self-Regulated "WebQuest" Learning System for Chinese Elementary Schools

    Science.gov (United States)

    Hsiao, Hsien-Sheng; Tsai, Chung-Chieh; Lin, Chien-Yu; Lin, Chih-Cheng

    2012-01-01

    The rapid growth of Internet has resulted in the rise of WebQuest learning recently. Teachers encourage students to participate in the searching for knowledge on different topics. When using WebQuest, students' self-regulation is often the key to successful learning. Therefore, this study establishes a self-regulated learning system to assist…

  17. Developing the support business-processes information system for self-regulation institute

    Directory of Open Access Journals (Sweden)

    Kravchenko Anatoly Vasilevich

    2011-11-01

    Full Text Available Studying the methods of sructurization, optimization and the automation for modern self-regulation institute business-processes are considered in the article. The aim of the text is to show the strategy of modeling self-regulation information system and the strategy of the membership dues accounting and agency compensation.

  18. 75 FR 71560 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS...

    Science.gov (United States)

    2010-11-24

    ... also asked what allowance is provided for contractors with accounting software that does not... RIN 0750-AG46 Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting... Regulation Supplement (DFARS) to address DoD Cost and Software Data Reporting system requirements for Major...

  19. Emotion Regulation via the Autonomic Nervous System in Children with Attention-Deficit/Hyperactivity Disorder (ADHD)

    Science.gov (United States)

    Musser, Erica D.; Backs, Richard W.; Schmitt, Colleen F.; Ablow, Jennifer C.; Measelle, Jeffery R.; Nigg, Joel T.

    2011-01-01

    Despite growing interest in conceptualizing ADHD as involving disrupted emotion regulation, few studies have examined the physiological mechanisms related to emotion regulation in children with this disorder. This study examined parasympathetic and sympathetic nervous system reactivity via measures of respiratory sinus arrhythmia (RSA) and cardiac…

  20. Financial regulation and financial system architecture in Central Europe

    NARCIS (Netherlands)

    Scholtens, B

    At the beginning of the transition, advice to Central European countries with respect to how to set up their financial systems was based on models used in western economies. This paper analyzes the experiences to set up a financial system in Central Europe. The experience in the first transition

  1. Insulin action in brain regulates systemic metabolism and brain function.

    Science.gov (United States)

    Kleinridders, André; Ferris, Heather A; Cai, Weikang; Kahn, C Ronald

    2014-07-01

    Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of appetite, reproductive function, body temperature, white fat mass, hepatic glucose output, and response to hypoglycemia. Insulin signaling also modulates neurotransmitter channel activity, brain cholesterol synthesis, and mitochondrial function. Disruption of insulin action in the brain leads to impairment of neuronal function and synaptogenesis. In addition, insulin signaling modulates phosphorylation of tau protein, an early component in the development of Alzheimer disease. Thus, alterations in insulin action in the brain can contribute to metabolic syndrome, and the development of mood disorders and neurodegenerative diseases. © 2014 by the American Diabetes Association.

  2. 48 CFR 2852.233-70 - Protests filed directly with the Department of Justice.

    Science.gov (United States)

    2010-10-01

    ... with the Department of Justice. 2852.233-70 Section 2852.233-70 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Clauses and Forms SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2852.233-70 Protests filed directly with the Department of Justice. As prescribed in 2833.102(d...

  3. 48 CFR 652.219-72 - Department of State Mentor-Protégé Program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Department of State Mentor....219-72 Department of State Mentor-Protégé Program. As prescribed in 619.202-70(o)(1), insert the following provision: Department of State Mentor-Protégé Program (APR 2004) (a) Large and small businesses...

  4. Department o

    African Journals Online (AJOL)

    USER

    2016-10-31

    Oct 31, 2016 ... Department of Urban and Regional Planning, University of Ibadan, Oyo State, Nigeria. 2 ... Geospatial techniques were used for this study; data from primary and secondary source ... development, for instance, Nigeria cities .... (road network, road medians and water ..... Countries: A Case Study of Nigeria.

  5. Electronics department

    International Nuclear Information System (INIS)

    1979-01-01

    This report summarizes the activities in 1978 of some of the groups within the Electronics Department. The work covered includes plant protection and operator studies, reliability techniques, application of nuclear techniques to mineral exploration, applied laser physics, computing and, lastly, research instrumentation. (author)

  6. Dynamic regulation of the endocannabinoid system: implications for analgesia

    Directory of Open Access Journals (Sweden)

    Wong Amy

    2009-10-01

    Full Text Available Abstract The analgesic effects of cannabinoids are well documented, but these are often limited by psychoactive side-effects. Recent studies indicate that the endocannabinoid system is dynamic and altered under different pathological conditions, including pain states. Changes in this receptor system include altered expression of receptors, differential synthetic pathways for endocannabinoids are expressed by various cell types, multiple pathways of catabolism and the generation of biologically active metabolites, which may be engaged under different conditions. This review discusses the evidence that pain states alter the endocannabinoid receptor system at key sites involved in pain processing and how these changes may inform the development of cannabinoid-based analgesics.

  7. Direct Torque Control System for Permanent Magnet Synchronous Machine with Fuzzy Speed Pi Regulator

    Science.gov (United States)

    Nabti, K.; Abed, K.; Benalla, H.

    2008-06-01

    The Permanent Magnet Synchronous Machine (PMSM) speed regulation with a conventional PI regulator reduces the speed control precision, increase the torque fluctuation, and consequentially low performances of the whole system. With utilisation of fuzzy logic method, this paper presents the self adaptation of conventional PI regulator parameters Kp and Ki (proportional and integral coefficients respectively), using to regulate the speed in Direct Torque Control strategy (DTC). The ripples of both torque and flux are reduced remarkable, small overshooting and good dynamic of the speed and torque. Simulation results verify the proposed method validity.

  8. Management System for Regulating Transport of Radioactive Material

    International Nuclear Information System (INIS)

    Lopez Vietri, J.R.; Capadona, N.M.; Barenghi, L.G.

    2011-01-01

    The objective of this paper is to describe the main characteristics of the Nuclear Regulatory Authority (Autoridad Regulatoria Nuclear - ARN) management system applied to the transport of radioactive material, in Argentina. In the frame of ARN's quality policy, 'Protection against ionizing radiation on transport of radioactive materials' was selected as one of the regulatory processes, named TMR from now on. ARN's management system is integrally based on ISO 9000 system addressed to help organizations in designing and implementing their quality management systems. TMR process was split into five sub processes in order to facilitate the implementation of the system. Such sub processes were defined taking into account of the main functions developed by ARN in the branch of safe transport of radioactive materials. For each of this processes were specified their objectives, inputs, activities and outputs, clients and stakeholders, responsibilities, supporting documents, control of documents and records, control of non-conformances, monitoring and measurements, audits, feedback and improvement. Supporting documents for sub processes were issued, validated, reviewed and improved as an essential point to achieve continuous improving. Simultaneously, some indexes were defined to monitor and measures sub processes as a way to show objective evidence of conformity with objectives. Finally, as conclusions of this paper, they will be showed the main obstacles and troubleshooting found in the design and implementation of management system as well as their solutions and state of advance. (authors)

  9. 78 FR 67927 - Foreign Trade Regulations (FTR): Mandatory Automated Export System Filing for All Shipments...

    Science.gov (United States)

    2013-11-13

    ... Internet at [email protected] ). FOR FURTHER INFORMATION CONTACT: Nick Orsini, Chief, Foreign Trade Division... 0607-AA50 Foreign Trade Regulations (FTR): Mandatory Automated Export System Filing for All Shipments... approval of new information collection requirements. [[Page 67928

  10. 75 FR 38765 - Domestic Origin Verification System Questionnaire and Regulations Governing Inspection and...

    Science.gov (United States)

    2010-07-06

    ..., facility assessment services, certifications of quantity and quality, import product inspections, and... control number. These include export certification, inspection of section 8e import products, and...] Domestic Origin Verification System Questionnaire and Regulations Governing Inspection and Certification of...

  11. Challenges of the banking regulation systems in the climate of the world economic crisis

    Directory of Open Access Journals (Sweden)

    Sedlarević Lazar

    2014-01-01

    Full Text Available At the end of the 20th century, banking systems of the developed countries have undergone multiple changes, where the basic dimensions of those changes were integration, deregulation and globalisation of activities. The resultant of these factors' actions was the creation of highly risky banking environment, which acted as a catalyst of the world economic crisis effects. These effects brought to the forefront weaknesses of the banking sector and of the banking regulation system, while emphasizing the need for their redefining. Hence this work examines in detail concrete models of the banking regulation systems in the European Union area and in the United States of America. In addition, directions of redefining regulation system were highlighted, and also the relevant differences between banking business regulation in the European Union and in the United States of America.

  12. Regulation of hippocampal neurogenesis by systemic factors including stress, glucocorticoids, sleep, and inflammation

    NARCIS (Netherlands)

    Lucassen, P.J.; Oomen, C.; van Dam, A.-M.; Czéh, B.; Gage, F.H.; Kempermann, G.; Song, H.

    2008-01-01

    This review summarizes and discusses the regulation of adult neurogenesis and hippocampal cellular plasticity by systemic factors. We focus on the role of stress, glucocorticoids, and related factors such as sleep deprivation and inflammation.

  13. Integrated cropping systems : an answer to environmental regulations imposed on nursery stock in the Netherlands

    NARCIS (Netherlands)

    Pronk, A.A.; Challa, H.

    2000-01-01

    Government regulations in the Netherlands are increasingly constraining and sometimes even banning conventional cultivation practices in nursery stock cropping systems. As a consequence, growers face problems concerning the use of manure, fertilisers and irrigation. In this study we analysed the

  14. Report: Wells Band Council Needs to Improve Its Accounting System to Comply With Federal Regulations

    Science.gov (United States)

    Report #14-2-0316, July 14, 2014. The Wells Band Council’s accounting system did not comply with federal regulations, which resulted in $390,000 of questioned costs and proposed high-risk designation for the grantee.

  15. Geographic information system for the study of coastal erosion in the Department of Cordoba, Colombia: design tools, and use

    International Nuclear Information System (INIS)

    Hoyos, Natalia; Acosta, Susana; Correa, Ivan D

    2006-01-01

    The study and monitoring of factors that cause shoreline erosion processes require the use of geographic information systems (GIS) to integrate and analyze data on different topics and with various formats. The scope of this project was to design and build a GIS for the study of erosion processes along the coastline of Cordoba Department, Colombia. In this article, we present some of the tools used for the SIG design and implementation, as well as a specific application for shoreline erosion analysis. The Geo database diagrammed tool (ArcGISa) was used to document the geo database structure. The process is semiautomatic and delivers a comprehensive and friendly format for the end users. Linear referencing and dynamic segmentation tools (ArcGISa) were used to characterize the coastline according to several criteria, without subdividing or duplicating it. Shoreline retreat between 1938 and 2004 was analyzed with OSAS (Digital shoreline analysis system, USGS). Maximum distance between both shorelines was recorded by a Punta Arboletes transect (972 m). Real (on the ground) maximum distance however, was larger (around 1.5 km). Nevertheless it was not recorded by any of the OSAS generated transect

  16. [Regulation of sporulation by two-component system YvcPQ in Bacillus thuringiensis].

    Science.gov (United States)

    Fan, Qingyun; Zhang, Shumeng; Gong, Yujing; He, Jin

    2017-01-04

    To study the regulation of sporulation controlled by two-component system (TCS) YvcPQ. β-galactosidase experiment was used to verify the regulation of YvcP on kapD expression; bacterial one-hybrid assay, EMSA and RT-qPCR were applied to study the regulation of AbrB on yvcPQ expression; markerless gene deletion coupled with spore count was used to reveal the influence of yvcPQ and kapD expressions on sporulation. transcriptional regulator AbrB up-regulated the expression of yvcPQ; YvcP promoted the expression of kapD to inhibit sporulation. AbrB up-regulated the transcription of yvcPQ operon, then the increased YvcP strengthened the transcriptional acitivation of sporulation inhibitor gene kapD, and subsequently inhibited sporulation.

  17. Assessment of the Plutonium Finishing Plant Criticality Alarm System U.S. Department of Energy Richland Operations Office

    International Nuclear Information System (INIS)

    NIRIDER, L.T.

    2002-01-01

    At the request of the Assistant Manager for Safety and Engineering, the U.S. Department of Energy Richland Operations Office (RL) Engineering Support Division, performed an oversight review of the Plutonium Finishing Plant (PFP) nuclear Criticality Alarm System (CAS). The review was conducted to satisfy requirements and agreements associated with Defense Nuclear Facility Safety Board (DNFSB) Recommendation 2000-2, ''Vital Safety Systems.'' The PFP is managed by Fluor Hanford, Inc. for RL. The field assessment and staff interviews were conducted August 12 through August 19,2002. This was a limited scope assessment that consisted of a review of the nuclear CAS operations, maintenance, and compliance with National Consensus Standards Requirements. The main purpose of the assessment was to determine the adequacy of the existing alarm system and its associated infrastructure to support the PFP facility mission through the remaining facility lifetime. The Review Plan was modeled upon Criteria and Review Approach Documents (CRAD) developed for DNFSB Recommendation 2000-2 reviews conducted across the Hanford Site. Concerns regarding component degradation and failure, increasing numbers of occurrence reports associated with the alarm system, and reliability issues were addressed. Additionally, RL performed a review of the engineering aspects of the CAS including the functions of design authorities and aspects of systems engineering. However, the focus of the assessment was on operations, maintenance, and reliability of the CAS, associated procurement practices, adequacy of safety and engineering policies and procedures, safety documentation, and fundamental engineering practices including training, qualification, and systems engineering. This assessment revealed that the PFP CAS and its associated infrastructure, administrative procedures, and conduct of operations are generally effective. There are no imminent criticality safety issues associated with the operation of the

  18. The Development of Innovation Systems as an Object with the State Regulation

    OpenAIRE

    Melnyk Alexander G.

    2017-01-01

    The article examines the processes of structuring the environment for the development of innovation systems in terms of the formation of a State regulated object. A methodological approach to definition of the State regulation at the primary, secondary and tertiary levels of structuring the environment of innovation systems has been suggested, based on the premise of the objective nature of the integration of social environment and market mechanisms into the structure of an object with the St...

  19. Stimuli-Regulated Smart Polymeric Systems for Gene Therapy

    Directory of Open Access Journals (Sweden)

    Ansuja Pulickal Mathew

    2017-04-01

    Full Text Available The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers.

  20. Development Of Linear Quadratic Regulator Design For Small UAV System

    Directory of Open Access Journals (Sweden)

    Cho Zin Myint

    2015-08-01

    Full Text Available The aim of this paper is to know the importance role of stability analysis for both unmanned aircraft system and for all control system. The objective of paper is to develop a method for dynamic stability analysis of the design process. These are categorized intoTo design model and stability analysis of UAV based on the forces and moment equations of aircraft dynamic model To choose the suitable controller for desired altitude of a particular UAV model To analyze the stability condition for aircraft using mathematical modeling and MATLAB. In this paper the analytical model of the longitudinal dynamic of flying wing UAV has been developed using aerodynamic data. The stability characteristics of UAV can be achieved from the system transfer function with LQR controller.

  1. A task management system for compliance with health, safety, and environmental regulations

    International Nuclear Information System (INIS)

    Crump, J.J.; O'Gorman, T.P.

    1992-01-01

    Shell Western E and P Inc. (SWEPI) has developed a new computer system to help it comply with health, safety, and environmental (HS and E) regulations. It is a task management system that functions at the detailed inventory level. It schedules work, instructs operations, and records compliance status. This article discusses design and development of the system

  2. 76 FR 28855 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration

    Science.gov (United States)

    2011-05-18

    ...; Business Systems-- Definition and Administration; Interim Rule #0;#0;Federal Register / Vol. 76 , No. 96...-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration... an initial proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038...

  3. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-09

    ..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...

  4. Dynamic regulation of neurotransmitter specification: Relevance to nervous system homeostasis

    Science.gov (United States)

    Borodinsky, Laura N.; Belgacem, Yesser Hadj; Swapna, Immani; Sequerra, Eduardo Bouth

    2013-01-01

    During nervous system development the neurotransmitter identity changes and coexpression of several neurotransmitters is a rather generalized feature of developing neurons. In the mature nervous system, different physiological and pathological circumstances recreate this phenomenon. The rules of neurotransmitter respecification are multiple. Among them, the goal of assuring balanced excitability appears as an important driving force for the modifications in neurotransmitter phenotype expression. The functional consequences of these dynamic revisions in neurotransmitter identity span a varied range, from fine-tuning the developing neural circuit to modifications in addictive and locomotor behaviors. Current challenges include determining the mechanisms underlying neurotransmitter phenotype respecification and how they intersect with genetic programs of neuronal specialization. PMID:23270605

  5. Studies on leptin and its feedback system for weight regulation

    International Nuclear Information System (INIS)

    Lei Chengzhi

    2002-01-01

    Recently the hormone leptin has been regarded as hormonal signal linking adipose tissue status with a number of key central nervous system circuits. The role of leptin and its feedback system in man is partly revealed. Hypothalamic centers appear to control appetite, metabolic rate and activity level in a co-ordinate manner. Within the hypothalamus, known weight regulatory molecules include leptin, neuropeptide Y and POMC. The authors integrated new information into a revised model for understanding this important regulatory process. The model of energy homeostasis propose that the interaction of leptin with various neuroendocrine pathway in the brain and in the periphery to affect food-take

  6. A study in improvement of administrative system in the nuclear safety regulation

    International Nuclear Information System (INIS)

    Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho

    2001-03-01

    One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents

  7. A study in improvement of administrative system in the nuclear safety regulation

    Energy Technology Data Exchange (ETDEWEB)

    Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho [Chungnam National Univ., Taejon (Korea, Republic of)

    2001-03-15

    One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents.

  8. System for measurement and automatic regulation of gas flow within an oil aging test device

    Directory of Open Access Journals (Sweden)

    Žigić Aleksandar

    2014-01-01

    Full Text Available This paper describes a system within an oil aging test device that serves for measurement and automatic regulation of gas flow. Following an already realized system that continuously monitors, logs, and regulates transformer oil temperature during the aging process and maintains temperature consistency within strict limits, a model of a flow meter and regulator of air or oxygen through transformer oil samples is developed. A special feature of the implemented system is the measurement of very small gas flows. A short technical description of the realized system is given with a functional block diagram. The basic technical characteristics of the system are specified, and the operating principles and application of the system are described. The paper also gives performance test results in a real exploitation environment.

  9. Multilevel Regulation of Bacterial Gene Expression with the Combined STAR and Antisense RNA System.

    Science.gov (United States)

    Lee, Young Je; Kim, Soo-Jung; Moon, Tae Seok

    2018-03-16

    Synthetic small RNA regulators have emerged as a versatile tool to predictably control bacterial gene expression. Owing to their simple design principles, small size, and highly orthogonal behavior, these engineered genetic parts have been incorporated into genetic circuits. However, efforts to achieve more sophisticated cellular functions using RNA regulators have been hindered by our limited ability to integrate different RNA regulators into complex circuits. Here, we present a combined RNA regulatory system in Escherichia coli that uses small transcription activating RNA (STAR) and antisense RNA (asRNA) to activate or deactivate target gene expression in a programmable manner. Specifically, we demonstrated that the activated target output by the STAR system can be deactivated by expressing two different types of asRNAs: one binds to and sequesters the STAR regulator, affecting the transcription process, while the other binds to the target mRNA, affecting the translation process. We improved deactivation efficiencies (up to 96%) by optimizing each type of asRNA and then integrating the two optimized asRNAs into a single circuit. Furthermore, we demonstrated that the combined STAR and asRNA system can control gene expression in a reversible way and can regulate expression of a gene in the genome. Lastly, we constructed and simultaneously tested two A AND NOT B logic gates in the same cell to show sophisticated multigene regulation by the combined system. Our approach establishes a methodology for integrating multiple RNA regulators to rationally control multiple genes.

  10. Electrical system regulations of the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Mello, Jose Roberto de; Madi Filho, Tufic

    2013-01-01

    The IEA-R1 reactor of the Nuclear and Energy Research Institute (IPEN-CNEN/SP), is a research reactor open pool type, designed and built by the U.S. firm Babcock and Wilcox, having, as coolant and moderator, deionized light water and beryllium and graphite, as reflectors. Until about 1988, the reactor safety systems received power from only one source of energy. As an example, it may be cited the control desk that was powered only by the vital electrical system 220V, which, in case the electricity fails, is powered by the generator group: no-break 220V. In the years 1989 and 1990, a reform of the electrical system upgrading to increase the reactor power and, also, to meet the technical standards of the ABNT (Associacao Brasileira de Normas Tecnicas) was carried out. This work has the objective of showing the relationship between the electric power system and the IEA-R1 reactor security. Also, it demonstrates that, should some electrical power interruption occur, during the reactor operation, this occurrence would not start an accident event. (author)

  11. Systemic Model for Optimal Regulation in Public Service

    Directory of Open Access Journals (Sweden)

    Lucica Matei

    2006-05-01

    Full Text Available The current paper inscribes within those approaching the issue of public services from the interdisciplinary perspective. Public service development and imposing standards of efficiency and effectiveness, as well as for citizens’ satisfaction bring in front line the systemic modelling and establishing optimal policies for organisation and functioning of public services. The issue under discussion imposes an interface with powerful determinations of social nature. Consequently, the most adequate modelling might be that with a probabilistic and statistic nature. The fundamental idea of this paper, that obviously can be broadly developed, starts with assimilating the way of organisation and functioning of a public service with a waiting thread, to which some hypotheses are associated concerning the order of provision, performance measurement through costs or waiting time in the system etc. We emphasise the openness and dynamics of the public service system, as well as modelling by turning into account the statistic knowledge and researches, and we do not make detailed remarks on the cybernetic characteristics of this system. The optimal adjustment is achieved through analysis on the feedback and its comparison with the current standards or good practices.

  12. The tumor macroenvironment and systemic regulation of breast cancer progression.

    Science.gov (United States)

    Castaño, Zafira; Tracy, Kristin; McAllister, Sandra S

    2011-01-01

    Breast cancer is the most common malignancy among women worldwide and is the most common cause of death for women between 35 and 50 years of age. Women with breast cancer are at risk of developing metastases for their entire lifetime and, despite local and systemic therapies, approximately 30% of breast cancer patients will relapse (Jemal et al., 2010). Nearly all breast cancer related deaths are due to metastatic disease, even though metastasis is considered to be an inefficient process. In some cases, tumor cells disseminate from primary sites at an early stage, but remain indolent for protracted periods of time before becoming overt, life-threatening tumors. Little is known about the mechanisms that cause these indolent tumors to grow into malignant disease. Because of this gap in our understanding, we are unable to predict which breast cancer patients are likely to experience disease relapse or develop metastases years after treatment of their primary tumor. A better understanding of the mechanisms and signals involved in the exit of tumor cells from dormancy would not only allow for more accurate selection of patients that would benefit from systemic therapy, but could also lead to the development of more targeted therapies to inhibit the signals that promote disease progression. In this review, we address the systemic, or "macroenvironmental", contribution to tumor initiation and progression and what is known about how a pro-tumorigenic systemic environment is established.

  13. Kisspeptin system in ovariectomized mice: Estradiol and progesterone regulation.

    Science.gov (United States)

    Marraudino, Marilena; Martini, Mariangela; Trova, Sara; Farinetti, Alice; Ponti, Giovanna; Gotti, Stefano; Panzica, GianCarlo

    2018-06-01

    The kisspeptin system is clustered in two main groups of cell bodies (the periventricular region, RP3V and the arcuate nucleus, ARC) that send fibers mainly to the GnRH neurons and in a few other locations, including the paraventricular nucleus, PVN. In physiological conditions, gonadal hormones modulate the kisspeptin system with expression changes according to different phases of the estrous cycle: the highest being in estrus phase in RP3V and PVN (positive feedback), and in ARC during the diestrus phase (negative feedback). In this work we wanted to study these hormonal fluctuations during the estrous cycle, investigating the role played by progesterone (P) or estradiol (E 2 ), alone or together, on the kisspeptin system. Gonadectomized CD1 female mice were treated with P, E 2 or both (E 2  + P), following a timing of administration that emulates the different phases of estrous cycle, for two cycles of 4 days. As expected, the two cell groups were differentially affected by E 2 ; the RP3V group was positively influenced by E 2 (alone or with the P), whereas in the ARC the administration of E 2 did not affect the system. However P (alone) induced a rise in the kisspeptin immunoreactivity. All the treatments significantly affected the kisspeptin innervation of the PVN, with regional differences, suggesting that these fibers arrive from both RP3V and ARC nuclei. Copyright © 2018 Elsevier B.V. All rights reserved.

  14. Food for thought: how nutrients regulate root system architecture.

    Science.gov (United States)

    Shahzad, Zaigham; Amtmann, Anna

    2017-10-01

    The spatial arrangement of the plant root system (root system architecture, RSA) is very sensitive to edaphic and endogenous signals that report on the nutrient status of soil and plant. Signalling pathways underpinning RSA responses to individual nutrients, particularly nitrate and phosphate, have been unravelled. Researchers have now started to investigate interactive effects between two or more nutrients on RSA. Several proteins enabling crosstalk between signalling pathways have recently been identified. RSA is potentially an important trait for sustainable and/or marginal agriculture. It is generally assumed that RSA responses are adaptive and optimise nutrient uptake in a given environment, but hard evidence for this paradigm is still sparse. Here we summarize recent advances made in these areas of research. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. Arabidopsis MAP kinase 4 negatively regulates systemic acquired resistance

    DEFF Research Database (Denmark)

    Petersen, M.; Brodersen, P.; Naested, H.

    2000-01-01

    Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) revels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern...... of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression....

  16. Stabilization and regulation of nonlinear systems a robust and adaptive approach

    CERN Document Server

    Chen, Zhiyong

    2015-01-01

    The core of this textbook is a systematic and self-contained treatment of the nonlinear stabilization and output regulation problems. Its coverage embraces both fundamental concepts and advanced research outcomes and includes many numerical and practical examples. Several classes of important uncertain nonlinear systems are discussed. The state-of-the art solution presented uses robust and adaptive control design ideas in an integrated approach which demonstrates connections between global stabilization and global output regulation allowing both to be treated as stabilization problems. Stabilization and Regulation of Nonlinear Systems takes advantage of rich new results to give students up-to-date instruction in the central design problems of nonlinear control, problems which are a driving force behind the furtherance of modern control theory and its application. The diversity of systems in which stabilization and output regulation become significant concerns in the mathematical formulation of practical contr...

  17. Modification of reference temperature program in reactor regulating system

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Sung Sik; Lee, Byung Jin; Kim, Se Chang; Cheong, Jong Sik [Korea Power Engineering Company, Inc., Seoul (Korea, Republic of); Kim, Ji In; Doo, Jin Yong [Korea Electric Power Cooperation, Yonggwang (Korea, Republic of)

    1999-12-31

    In Yonggwang nuclear units 3 and 4 currently under commercial operation, the cold temperature was very close to the technical specification limit of 298 deg C during initial startup testing, which was caused by the higher-than-expected reactor coolant system flow. Accordingly, the reference temperature (Tref) program needed to be revised to allow more flexibility for plant operations. In this study, the method of a specific test performed at Yonggwang nuclear unit 4 to revise the Tref program was described and the test results were discussed. In addition, the modified Tref program was evaluated on its potential impacts on system performance and safety. The methods of changing the Tref program and the associated pressurizer level setpoint program were also explained. Finally, for Ulchin nuclear unit 3 and 4 currently under initial startup testing, the effects of reactor coolant system flow rate on the coolant temperature were evaluated from the thermal hydraulic standpoint and an optimum Tref program was recommended. 6 refs., 4 figs., 2 tabs. (Author)

  18. Modification of reference temperature program in reactor regulating system

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Sung Sik; Lee, Byung Jin; Kim, Se Chang; Cheong, Jong Sik [Korea Power Engineering Company, Inc., Seoul (Korea, Republic of); Kim, Ji In; Doo, Jin Yong [Korea Electric Power Cooperation, Yonggwang (Korea, Republic of)

    1998-12-31

    In Yonggwang nuclear units 3 and 4 currently under commercial operation, the cold temperature was very close to the technical specification limit of 298 deg C during initial startup testing, which was caused by the higher-than-expected reactor coolant system flow. Accordingly, the reference temperature (Tref) program needed to be revised to allow more flexibility for plant operations. In this study, the method of a specific test performed at Yonggwang nuclear unit 4 to revise the Tref program was described and the test results were discussed. In addition, the modified Tref program was evaluated on its potential impacts on system performance and safety. The methods of changing the Tref program and the associated pressurizer level setpoint program were also explained. Finally, for Ulchin nuclear unit 3 and 4 currently under initial startup testing, the effects of reactor coolant system flow rate on the coolant temperature were evaluated from the thermal hydraulic standpoint and an optimum Tref program was recommended. 6 refs., 4 figs., 2 tabs. (Author)

  19. User acceptance of a picture archiving and communication system (PACS in a Saudi Arabian hospital radiology department

    Directory of Open Access Journals (Sweden)

    Aldosari Bakheet

    2012-05-01

    Full Text Available Abstract Background Compared with the increasingly widespread use of picture archiving and communication systems (PACSs, knowledge concerning users’ acceptance of such systems is limited. Knowledge of acceptance is needed given the large (and growing financial investment associated with the implementation of PACSs, and because the level of user acceptance influences the degree to which the benefits of the systems for healthcare can be realized. Methods A Technology Acceptance Model (TAM was used to assess the level of acceptance of the host PACS by staff in the radiology department at King Abdulaziz Medical City (KAMC, Riyadh, Saudi Arabia. A questionnaire survey of 89 PACS users was employed to obtain data regarding user characteristics, perceived usefulness (PU (6 items, perceived ease of use (PEU (4 items, a change construct (4 items, and a behavior (acceptance construct (9 items. Respondents graded each item in each construct using five-point likert scales. Results Surveyed users reported high levels of PU (4.33/5, PEU (4.15/5, change (4.26/5, and acceptance (3.86/5. The three constructs of PU, PEU, and change explained 41 % of the variation in PACS user acceptance. PU was the most important predictor, explaining 38 % of the variation on its own. The most important single item in the explanatory constructs was that users found PACS to have improved the quality of their work in providing better patient care. Technologists had lower acceptance ratings than did clinicians/radiologists, but no influence on acceptance level was found due to gender, age, or length of experience using the PACS. Although not directly measured, there appeared to be no cultural influence on either the level of acceptance or its determinants. Conclusions User acceptance must be considered when an organization implements a PACS, in order to enhance its successful adoption. Health organizations should adopt a PACS that offers all required functions and which is

  20. Department of Energy's Biological and Environmental Research Strategic Data Roadmap for Earth System Science

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Palanisamy, Giri [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shipman, Galen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boden, Thomas A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Voyles, Jimmy W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-04-25

    Rapid advances in experimental, sensor, and computational technologies and techniques are driving exponential growth in the volume, acquisition rate, variety, and complexity of scientific data. This wealth of scientifically meaningful data has tremendous potential to lead to scientific discovery. However, to achieve scientific breakthroughs, these data must be exploitable—they must be analyzed effectively and efficiently and the results shared and communicated easily within the wider Department of Energy’s (DOE’s) Biological and Environmental Research (BER) Climate and Environmental Sciences Division (CESD) community. The explosion in data complexity and scale makes these tasks exceedingly difficult to achieve, particularly given that an increasing number of disciplines are working across techniques, integrating simulation and experimental or observational results (see Table 5 in Appendix 2). Consequently, we need new approaches to data management, analysis, and visualization that provide research teams with easy-to-use and scalable end-to-end solutions. These solutions must facilitate (and where feasible, automate and capture) every stage in the data lifecycle (shown in Figure 1), from collection to management, annotation, sharing, discovery, analysis, and visualization. In addition, the core functionalities are the same across climate science communities, but they require customization to adapt to specific needs and fit into research and analysis workflows. To this end, the mission of CESD’s Data and Informatics Program is to integrate all existing and future distributed CESD data holdings into a seamless and unified environment for the acceleration of Earth system science.

  1. Nighttime assaults: using a national emergency department monitoring system to predict occurrence, target prevention and plan services

    Directory of Open Access Journals (Sweden)

    Bellis Mark A

    2012-09-01

    Full Text Available Abstract Background Emergency department (ED data have the potential to provide critical intelligence on when violence is most likely to occur and the characteristics of those who suffer the greatest health impacts. We use a national experimental ED monitoring system to examine how it could target violence prevention interventions towards at risk communities and optimise acute responses to calendar, holiday and other celebration-related changes in nighttime assaults. Methods A cross-sectional examination of nighttime assault presentations (6.01 pm to 6.00 am; n = 330,172 over a three-year period (31st March 2008 to 30th March 2011 to English EDs analysing changes by weekday, month, holidays, major sporting events, and demographics of those presenting. Results Males are at greater risk of assault presentation (adjusted odds ratio [AOR] 3.14, 95% confidence intervals [CIs] 3.11-3.16; P 2 = 0.918; P  Conclusions To date, the role of ED data has focused on helping target nightlife police activity. Its utility is much greater; capable of targeting and evaluating multi-agency life course approaches to violence prevention and optimising frontline resources. National ED data are critical for fully engaging health services in the prevention of violence.

  2. Hypothesis: the regulation of the partial pressure of oxygen by the serotonergic nervous system in hypoxia.

    Science.gov (United States)

    Devereux, Diana; Ikomi-Kumm, Julie

    2013-03-01

    The regulation of the partial pressure of oxygen by the serotonergic nervous system in hypoxia is a hypothesis, which proposes an inherent operative system in homo sapiens that allows central nervous system and endocrine-mediated vascular system adaption to variables in partial pressure of oxygen, pH and body composition, while maintaining sufficient oxygen saturation for the immune system and ensuring protection of major organs in hypoxic and suboptimal conditions. While acknowledging the importance of the Henderson-Hasselbalch equation in the regulation of acid base balance, the hypothesis seeks to define the specific neuroendocrine/vascular mechanisms at work in regulating acid base balance in hypoxia and infection. The SIA (serotonin-immune-adrenergic) system is proposed as a working model, which allows central nervous system and endocrine-mediated macro- and micro vascular 'fine tuning'. The neurotransmitter serotonin serves as a 'hypoxic sensor' in concert with other operators to orchestrate homeostatic balance in normal and pathological states. The SIA system finely regulates oxygen, fuel and metabolic buffering systems at local sites to ensure optimum conditions for the immune response. The SIA system is fragile and its operation may be affected by infection, stress, diet, environmental toxins and lack of exercise. The hypothesis provides new insight in the area of neuro-gastroenterology, and emphasizes the importance of diet and nutrition as a complement in the treatment of infection, as well as the normalization of intestinal flora following antibiotic therapy. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Systemic risk in the energy sector—Is there need for financial regulation?

    International Nuclear Information System (INIS)

    Kerste, Marco; Gerritsen, Matthijs; Weda, Jarst; Tieben, Bert

    2015-01-01

    The credit crisis points at serious systemic risks in Over The Counter derivative trading. This has resulted in new financial regulation, covering both the financial sector and non-financial sectors. The actual extent to which non-financial companies trading on OTC markets contribute to systemic risk has hardly been the subject of research. This paper investigates the need for financial regulation in the energy sector, which shows a high use of OTC derivatives, by modeling systemic risk measured by the expected fraction of additional failing firms (EAF). Contagion risk within the energy sector and from the energy sector towards the banking sector is compared with that in other non-financial sectors. This paper adds to existing systemic risk literature by specifically looking at financial interdependence between a non-financial sector showing a high usage of OTC commodity derivatives and the banking sector, while contributing to the discussion on energy sector regulation with technical systemic risk analysis. Results indicate that contagion risk from the energy towards the banking sector is not relatively high compared to other non-financial sectors. Our results provide a first indication to question the need for generalized regulation of OTC derivative transactions, as recently introduced by the European Market Infrastructure Regulation (EMIR). - Highlights: • We assess the need for regulating OTC energy commodity derivatives under EMIR. • We present a methodology to model systemic risk in non-financial sectors. • We analyse direct and indirect channels for contagion giving rise to systemic risk. • Contagion risk from the energy towards the banking sector is not relatively high. • New EU regulation for energy OTC trading not supported by analysis of systemic risk

  4. Immune Evasion, Immunopathology and the Regulation of the Immune System

    Directory of Open Access Journals (Sweden)

    Bruno Faivre

    2013-02-01

    Full Text Available Costs and benefits of the immune response have attracted considerable attention in the last years among evolutionary biologists. Given the cost of parasitism, natural selection should favor individuals with the most effective immune defenses. Nevertheless, there exists huge variation in the expression of immune effectors among individuals. To explain this apparent paradox, it has been suggested that an over-reactive immune system might be too costly, both in terms of metabolic resources and risks of immune-mediated diseases, setting a limit to the investment into immune defenses. Here, we argue that this view neglects one important aspect of the interaction: the role played by evolving pathogens. We suggest that taking into account the co-evolutionary interactions between the host immune system and the parasitic strategies to overcome the immune response might provide a better picture of the selective pressures that shape the evolution of immune functioning. Integrating parasitic strategies of host exploitation can also contribute to understand the seemingly contradictory results that infection can enhance, but also protect from, autoimmune diseases. In the last decades, the incidence of autoimmune disorders has dramatically increased in wealthy countries of the northern hemisphere with a concomitant decrease of most parasitic infections. Experimental work on model organisms has shown that this pattern may be due to the protective role of certain parasites (i.e., helminths that rely on the immunosuppression of hosts for their persistence. Interestingly, although parasite-induced immunosuppression can protect against autoimmunity, it can obviously favor the spread of other infections. Therefore, we need to think about the evolution of the immune system using a multidimensional trade-off involving immunoprotection, immunopathology and the parasitic strategies to escape the immune response.

  5. Radiation regulation

    International Nuclear Information System (INIS)

    Braithwaite, J.; Grabosky, P.

    1985-01-01

    The five main areas of radiation regulation considered are radiation exposure in the mining of uranium and other minerals, exposure in the use of uranium in nuclear reactors, risks in the transport of radioactive materials and hazards associated with the disposal of used materials. In Australia these problems are regulated by mines departments, the Australian Atomic Energy Commission and radiation control branches in state health departments. Each of these instutional areas of regulation is examined

  6. Unmanned Aerial Systems, Moored Balloons, and the U.S. Department of Energy ARM Facilities in Alaska

    Science.gov (United States)

    Ivey, Mark; Verlinde, Johannes

    2014-05-01

    The U.S. Department of Energy (DOE), through its scientific user facility, the Atmospheric Radiation Measurement (ARM) Climate Research Facility, provides scientific infrastructure and data to the international Arctic research community via its research sites located on the North Slope of Alaska. Facilities and infrastructure to support operations of unmanned aerial systems for science missions in the Arctic and North Slope of Alaska were established at Oliktok Point Alaska in 2013. Tethered instrumented balloons will be used in the near future to make measurements of clouds in the boundary layer including mixed-phase clouds. The DOE ARM Program has operated an atmospheric measurement facility in Barrow, Alaska, since 1998. Major upgrades to this facility, including scanning radars, were added in 2010. Arctic Observing Networks are essential to meet growing policy, social, commercial, and scientific needs. Calibrated, high-quality arctic geophysical datasets that span ten years or longer are especially important for climate studies, climate model initializations and validations, and for related climate policy activities. For example, atmospheric data and derived atmospheric forcing estimates are critical for sea-ice simulations. International requirements for well-coordinated, long-term, and sustained Arctic Observing Networks and easily-accessible data sets collected by those networks have been recognized by many high-level workshops and reports (Arctic Council Meetings and workshops, National Research Council reports, NSF workshops and others). The recent Sustaining Arctic Observation Network (SAON) initiative sponsored a series of workshops to "develop a set of recommendations on how to achieve long-term Arctic-wide observing activities that provide free, open, and timely access to high-quality data that will realize pan-Arctic and global value-added services and provide societal benefits." This poster will present information on opportunities for members of the

  7. Algorithm for the prophylaxis of septic complications in orthopedics and traumatology of locomotor system at the Department of Orthopedics at the Postgraduate Medical Education Center in Otwock.

    Science.gov (United States)

    Białecki, Jerzy; Brychcy, Adrian; Marczyński, Wojciech Józef

    2013-09-18

    Current state of knowledge in a matter of septic complications after procedures with orthopaedic device implantation with particular consideration of THA and TKA is presented in the paper. Implant biocompatibility phenomenon as well as systemic reaction to its presence is also discussed. Algorithm for prophylactics of septic complications followed in Orthopaedic Department of PMEC in Otwock is introduced. Article is based on clinical observations of Orthopaedic Department's PMEC team.  

  8. Self-regulating chemo-mechano-chemical systems

    Science.gov (United States)

    Aizenberg, Joanna; He, Ximin; Aizenberg, Michael

    2017-05-16

    A chemo-mechano-chemical (C.sub.1-M-C.sub.2) system includes a base supporting an actuatable structure, said structure comprising a functionalized portion and being embedded in an environmentally responsive gel capable of volume change in response to an environmental stimulus; a first fluid layer disposed over the base and in contact with the actuatable structure, said first fluid layer comprising the environmentally responsive gel; and a second fluid layer in contact with the actuatable structure, wherein the layers are positioned such that the functionalized portion is in contact with the second layer in a first relaxed state and in contact with the first layer in a second actuated state and wherein the functionalized portion interacts with at least one of the layers to provide a chemical or physical response.

  9. Regulation of the renin-angiotensin-aldosterone system in fibromyalgia.

    Science.gov (United States)

    Maliszewski, Anne M; Goldenberg, Don L; Hurwitz, Shelley; Adler, Gail K

    2002-07-01

    To assess the function of the renin-angiotensin-aldosterone (RAA) system in women with fibromyalgia (FM) compared to healthy women. Women with FM [n = 14, age 41.0+/-7.2 yrs, body mass index (BMI) 26.4+/-5.4 kg/m2] and healthy women (n = 13, age 40.0+/-7.7 yrs, BMI 25.0+/-5.0 kg/m2) were placed on a low sodium diet (10 mEq sodium/day) for 5 days. After being supine and fasting overnight, subjects received an intravenous infusion of angiotensin II at successive doses of 1, 3, and 10 ng/kg/min for 45 min per dose. Blood pressure (BP), plasma renin activity (PRA), aldosterone, and cortisol were measured at baseline and after each dose of angiotensin II. Prior to sodium restriction, women with FM completed the Hopkins Symptom Checklist-90, which included a question grading the extent of dizziness/faintness on a scale of 0 (none) to 4 (extremely). After dietary sodium restriction, baseline PRA, aldosterone, and supine BP were similar in healthy women and women with FM. Aldosterone and BP rose in response to infused angiotensin II; these responses did not differ significantly between healthy women and women with FM. In women with FM, symptoms of dizziness correlated inversely with BMI (r = -0.81, p < 0.001) and the systolic BP response to 10 ng/kg/min angiotensin II (r = -0.81, p < 0.001). The functioning of the RAA system, including the vascular response to angiotensin II, was intact in women with FM compared to healthy women. However, women with FM who complained of dizziness had a blunted vascular response to angiotensin II. This blunted vascular response may indicate intravascular volume depletion in women with symptoms of dizziness.

  10. The effect of some growth regulators on enzyme systems in irradiated barley grain using disinfestation doses

    International Nuclear Information System (INIS)

    Bachman, S.

    1973-01-01

    Disinfestation doses of 20 to 100 krad may cause changes in the biological systems of barley grain and, therefore, may influence undesirably the technological quality of malted grain. The effect of some growth regulators on irradiated grain has been investigated. The experiments have been carried out on brewery barley var. Visa Breuns. Following growth-regulators were used: gibberellic acid (Polish preparation ''Gibrescol''), kinetin (6-furfurylo-aminopurin), CCC (2-chloroethyl trimethyl ammonium chloride), and betaine hydrochloride. By treating the irradiated barley with solutions of growth regulators it was possible to diminish the loss of enzyme activity. A ''regenerating'' effect of growth substances, mainly gibberellic acid and betain hydrochloride in 10 -4 M solutions, was observed. Amylolytic activity decreased immediately after irradiation but in samples treated with growth regulators it was higher than in those without regulators. The results may have a practical importance since gibberellic acid has just been introduced into the brewery industry. (F.J.)

  11. Probiotics and the Gut Immune System: Indirect Regulation.

    Science.gov (United States)

    La Fata, Giorgio; Weber, Peter; Mohajeri, M Hasan

    2018-03-01

    The gastrointestinal tract (GIT) represents the largest interface between the human organism and the external environment. In the lumen and upper part of the mucus layer, this organ hosts an enormous number of microorganisms whose composition affects the functions of the epithelial barrier and the gut immune system. Consequentially, the microorganisms in the GIT influence the health status of the organism. Probiotics are living microorganisms which, in specific conditions, confer a health benefit to the host. Among others, probiotics have immunomodulatory properties that usually act directly by (a) increasing the activity of macrophages or natural killer cells, (b) modulating the secretion of immunoglobulins or cytokines, or indirectly by (c) enhancing the gut epithelial barrier, (d) altering the mucus secretion, and (e) competitive exclusion of other (pathogenic) bacteria. This review focuses on specific bacteria strains with indirect immunomodulatory properties. Particularly, we describe here the mechanisms through which specific probiotics enhance the gut epithelial barrier and modulate mucus production. Moreover, we describe the antimicrobial properties of specific bacteria strains. Recent data suggest that multiple pathologies are associated with an unbalanced gut microflora (dysbiosis). Although the cause-effect relationship between pathology and gut microflora is not yet well established, consumption of specific probiotics may represent a powerful tool to re-establish gut homeostasis and promote gut health.

  12. Coordinated Regulation of Virulence during Systemic Infection of Salmonella enterica serovar Typhimurium

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hyunjin; McDermott, Jason E.; Porwollik, Steffen; Mcclelland, Michael; Heffron, Fred

    2009-02-20

    Salmonella must respond to a myriad of environmental cues during infection of a mouse and express specific subsets of genes in a temporal and spatial manner to subvert the host defense mechanisms but these regulatory pathways are poorly established. To unravel how micro-environmental signals are processed and integrated into coordinated action, we constructed in-frame non-polar deletions of 84 regulators inferred to play a role in Salmonella typhimurium virulence and tested them in three virulence assays (intraperitoneal (i.p.), and intragastric (i.g.) infection in BALB/c mice, and persistence in SvJ129 mice). Overall 36 regulators were identified that were less virulent in at least one assay, and of those, 15 regulators were required for systemic mouse infection in an acute infection model. As a first step towards understanding the interplay between a pathogen and its host from a systems biology standpoint we focused on these 15 genes. Transcriptional profiles were obtained for each of these 15 regulators from strains grown under four different environmental conditions. These results as well as publicly available transcriptional profiles were analyzed using both network inference and cluster analysis algorithms. The analysis predicts a regulatory network in which all 15 regulators control a specific set of genes necessary for Salmonella to cause systemic infection. We tested the regulatory model by expressing a subset of the regulators in trans and monitoring transcription of 7 known virulence factors located within Salmonella pathogenicity island 2 (SPI-2). These experiments validated the regulatory model and showed that, for these 7 genes, the response regulator SsrB and the marR type regulator SlyA co-regulate in a regulatory cascade by integrating multiple signals.

  13. Regulation and drive system for high rep-rate magnetic-pulse compressors

    International Nuclear Information System (INIS)

    Birx, D.L.; Cook, E.G.; Hawkins, S.; Meyers, A.; Reginato, L.L.; Schmidt, J.A.; Smith, M.W.

    1982-01-01

    The essentially unlimited rep-rate capability of non-linear magnetic systems has imposed strict requirements on the drive system which initiates the pulse compression. An order of magnitude increase in the rep-rates achieved by the Advanced Test Accelerator (ATA) gas blown system is not difficult to achieve in the magnetic compressor. The added requirement of having a high degree of regulation at the higher rep-rates places strict requirements on the triggerable switch for charging and de-Queing. A novel feedback technique which applies the proper bias to a magnetic core by comparing a reference voltage to the charging voltage eases considerably the regulation required to achieve low jitter in magnetic compression. The performance of the high rep-rate charging and regulation systems will be described in the following pages

  14. General organisational principles of the transcriptional regulation system: a tree or a circle?

    Science.gov (United States)

    Muskhelishvili, Georgi; Sobetzko, Patrick; Geertz, Marcel; Berger, Michael

    2010-04-01

    Recent advances of systemic approaches to gene expression and cellular metabolism provide unforeseen opportunities for relating and integrating extensive datasets describing the transcriptional regulation system as a whole. However, due to the multifaceted nature of the phenomenon, these datasets often contain logically distinct types of information determined by underlying approach and adopted methodology of data analysis. Consequently, to integrate the datasets comprising information on the states of chromatin structure, transcriptional regulatory network and cellular metabolism, a novel methodology enabling interconversion of logically distinct types of information is required. Here we provide a holistic conceptual framework for analysis of global transcriptional regulation as a system coordinated by structural coupling between the transcription machinery and DNA topology, acting as interdependent sensors and determinants of metabolic functions. In this operationally closed system any transition in physiological state represents an emergent property determined by shifts in structural coupling, whereas genetic regulation acts as a genuine device converting one logical type of information into the other.

  15. Almost output regulation of LFT systems via gain-scheduling control

    Science.gov (United States)

    Yuan, Chengzhi; Duan, Chang; Wu, Fen

    2018-05-01

    Output regulation of general uncertain systems is a meaningful yet challenging problem. In spite of the rich literature in the field, the problem has not yet been addressed adequately due to the lack of an effective design mechanism. In this paper, we propose a new design framework for almost output regulation of uncertain systems described in the general form of linear fractional transformation (LFT) with time-varying parametric uncertainties and unknown external perturbations. A novel semi-LFT gain-scheduling output regulator structure is proposed, such that the associated control synthesis conditions guaranteeing both output regulation and ? disturbance attenuation performance are formulated as a set of linear matrix inequalities (LMIs) plus parameter-dependent linear matrix equations, which can be solved separately. A numerical example has been used to demonstrate the effectiveness of the proposed approach.

  16. Calculational-theoretical studies of the system of local automated regulators and lateral ionization chambers

    International Nuclear Information System (INIS)

    Aleksakov, A.N.; Emel'yanov, I.Ya.; Nikolaev, E.V.; Panin, V.M.; Podlazov, L.N.; Rogova, V.D.

    1987-01-01

    Methods of engineering synthesis of the systems for nuclear reactor local automated power regulation and radial-azimuthal energy distribution stabilization operating according to lateral ionization chamber signals are described. Results of calculational-theoretical investigations into the system efficiency and peculiarities of its reaction to some perturbations typical of the RBMK type reactors are considered

  17. Systemic risk in the energy sector: is there need for financial regulation?

    NARCIS (Netherlands)

    Kerste, M.; Gerritsen, M.; Weda, J.; Tieben, B.

    2015-01-01

    The credit crisis points at serious systemic risks in Over The Counter derivative trading. This has resulted in new financial regulation, covering both the financial sector and non-financial sectors. The actual extent to which non-financial companies trading on OTC markets contribute to systemic

  18. A Story of Three Bank-Regulatory Legal Systems: Contract, Financial Management Regulation and Fiduciary Law

    Directory of Open Access Journals (Sweden)

    Tamar Frankel

    2016-08-01

    Full Text Available How should banks be regulated to avoid their failure? Banks must control the risks they take with depositors' money. If depositors lose their trust in their banks, and demand their money, the banks will fail. This article describes three legal bank regulatory systems: Contract with depositors (U.S.; a mix of contract and trust law, but going towards trust (Japan and a full trust-fiduciary law regulating banks (Israel. The article concludes that bank regulation, which limits the banks' risks and conflicts of interest, helps create trustworthy banks that serve their country best.

  19. Right, laws, regulations and technical building systems; Recht, Gesetze, Verordnungen und Technische Gebaeudesysteme

    Energy Technology Data Exchange (ETDEWEB)

    Kranz, H.R. [Siemens AG, Karlsruhe (Germany)

    1995-12-31

    Chapter 23 of the anthology about building control gives an overview of the laws and regulations in the field of technical building systems. The following fields are discussed: license regulations in the field of building trade, communication law, environmental responsibility law, building right, European directives, laws and regulations of the Federal Government and the Laender. (BWI) [Deutsch] Kapitel 23 des Sammelbandes ueber Building Control gibt einen Ueberblick ueber Recht, Gesetze und Verordnungen im Bereich der Technischen Gebaeudesysteme. In diesem Zusammenhang kommen folgende Bereiche in Frage: Lizenzrecht im Bauwesen; Fernmelderecht; Umwelthaftungsgesetz; Baurecht; Europaeische Richtlinien; Gesetze und Verordnungen des Bundes und der Laender. (BWI)

  20. A three-dimensional operational transient simulation of the CANDU core with typical reactor regulating system

    Energy Technology Data Exchange (ETDEWEB)

    Yeom, Choong Sub; Kim, Hyun Dae; Park, Kyung Seok; Park, Jong Woon [Institute for Advanced Engineering, Taejon (Korea, Republic of)

    1995-07-01

    This paper describes the results of simulation of a CANDU operational transient problem (re-startup after short shutdown) using the Coupled Reactor Kinetics(CRKIN) code developed previously with CANDU Reactor Regulating System (RRS) logic. The performance in the simulation is focused on investigating the behaviours of neutron power and regulating devices in accordance with the changes of xenon concentration following the operation of the RRS.

  1. Low-frequency dynamics of autonomic regulation of circulatory system in healthy subjects

    Science.gov (United States)

    Skazkina, V. V.; Borovkova, E. I.; Galushko, T. A.; Khorev, V. S.; Kiselev, A. R.

    2018-04-01

    The paper is devoted to the analysis of dynamic of interactions between signals of autonomic circulatory regulation. We investigated two-hour experimental records of 30 healthy people. Phase synchronization was studied using the signals of the electrocardiogram and the photoplethysmogram of vessels. We found the presence of long synchronous intervals in some subjects. For analysis of the dynamic we calculated autocorrelation functions. The analysis made it possible to reveal indirect signs of the influence of the humoral regulation system.

  2. Outpatient and Ambulatory Surgery Consumer Assessment of Healthcare Providers and Systems (OAS CAHPS) survey for hospital outpatient departments - National

    Data.gov (United States)

    U.S. Department of Health & Human Services — The national average for the OAS CAHPS Survey categories. The OAS CAHPS survey collects information about patients’ experiences of care in hospital outpatient...

  3. Outpatient and Ambulatory Surgery Consumer Assessment of Healthcare Providers and Systems (OAS CAHPS) survey for hospital outpatient departments - State

    Data.gov (United States)

    U.S. Department of Health & Human Services — A list of the state averages for the OAS CAHPS Survey responses. The OAS CAHPS survey collects information about patients’ experiences of care in hospital outpatient...

  4. Structural elements regulating amyloidogenesis: a cholinesterase model system.

    Directory of Open Access Journals (Sweden)

    Létitia Jean

    2008-03-01

    Full Text Available Polymerization into amyloid fibrils is a crucial step in the pathogenesis of neurodegenerative syndromes. Amyloid assembly is governed by properties of the sequence backbone and specific side-chain interactions, since fibrils from unrelated sequences possess similar structures and morphologies. Therefore, characterization of the structural determinants driving amyloid aggregation is of fundamental importance. We investigated the forces involved in the amyloid assembly of a model peptide derived from the oligomerization domain of acetylcholinesterase (AChE, AChE(586-599, through the effect of single point mutations on beta-sheet propensity, conformation, fibrilization, surfactant activity, oligomerization and fibril morphology. AChE(586-599 was chosen due to its fibrilization tractability and AChE involvement in Alzheimer's disease. The results revealed how specific regions and residues can control AChE(586-599 assembly. Hydrophobic and/or aromatic residues were crucial for maintaining a high beta-strand propensity, for the conformational transition to beta-sheet, and for the first stage of aggregation. We also demonstrated that positively charged side-chains might be involved in electrostatic interactions, which could control the transition to beta-sheet, the oligomerization and assembly stability. Further interactions were also found to participate in the assembly. We showed that some residues were important for AChE(586-599 surfactant activity and that amyloid assembly might preferentially occur at an air-water interface. Consistently with the experimental observations and assembly models for other amyloid systems, we propose a model for AChE(586-599 assembly in which a steric-zipper formed through specific interactions (hydrophobic, electrostatic, cation-pi, SH-aromatic, metal chelation and polar-polar would maintain the beta-sheets together. We also propose that the stacking between the strands in the beta-sheets along the fiber axis could

  5. Modeling and Performance Improvement of the Constant Power Regulator Systems in Variable Displacement Axial Piston Pump

    Science.gov (United States)

    Park, Sung Hwan; Lee, Ji Min; Kim, Jong Shik

    2013-01-01

    An irregular performance of a mechanical-type constant power regulator is considered. In order to find the cause of an irregular discharge flow at the cut-off pressure area, modeling and numerical simulations are performed to observe dynamic behavior of internal parts of the constant power regulator system for a swashplate-type axial piston pump. The commercial numerical simulation software AMESim is applied to model the mechanical-type regulator with hydraulic pump and simulate the performance of it. The validity of the simulation model of the constant power regulator system is verified by comparing simulation results with experiments. In order to find the cause of the irregular performance of the mechanical-type constant power regulator system, the behavior of main components such as the spool, sleeve, and counterbalance piston is investigated using computer simulation. The shape modification of the counterbalance piston is proposed to improve the undesirable performance of the mechanical-type constant power regulator. The performance improvement is verified by computer simulation using AMESim software. PMID:24282389

  6. Modeling and Performance Improvement of the Constant Power Regulator Systems in Variable Displacement Axial Piston Pump

    Directory of Open Access Journals (Sweden)

    Sung Hwan Park

    2013-01-01

    Full Text Available An irregular performance of a mechanical-type constant power regulator is considered. In order to find the cause of an irregular discharge flow at the cut-off pressure area, modeling and numerical simulations are performed to observe dynamic behavior of internal parts of the constant power regulator system for a swashplate-type axial piston pump. The commercial numerical simulation software AMESim is applied to model the mechanical-type regulator with hydraulic pump and simulate the performance of it. The validity of the simulation model of the constant power regulator system is verified by comparing simulation results with experiments. In order to find the cause of the irregular performance of the mechanical-type constant power regulator system, the behavior of main components such as the spool, sleeve, and counterbalance piston is investigated using computer simulation. The shape modification of the counterbalance piston is proposed to improve the undesirable performance of the mechanical-type constant power regulator. The performance improvement is verified by computer simulation using AMESim software.

  7. Modeling and performance improvement of the constant power regulator systems in variable displacement axial piston pump.

    Science.gov (United States)

    Park, Sung Hwan; Lee, Ji Min; Kim, Jong Shik

    2013-01-01

    An irregular performance of a mechanical-type constant power regulator is considered. In order to find the cause of an irregular discharge flow at the cut-off pressure area, modeling and numerical simulations are performed to observe dynamic behavior of internal parts of the constant power regulator system for a swashplate-type axial piston pump. The commercial numerical simulation software AMESim is applied to model the mechanical-type regulator with hydraulic pump and simulate the performance of it. The validity of the simulation model of the constant power regulator system is verified by comparing simulation results with experiments. In order to find the cause of the irregular performance of the mechanical-type constant power regulator system, the behavior of main components such as the spool, sleeve, and counterbalance piston is investigated using computer simulation. The shape modification of the counterbalance piston is proposed to improve the undesirable performance of the mechanical-type constant power regulator. The performance improvement is verified by computer simulation using AMESim software.

  8. A voltage regulator system with dynamic bandwidth boosting for passive UHF RFID transponders

    International Nuclear Information System (INIS)

    Shen Jinpeng; Wang Xin'an; Liu Shan; Li Shoucheng; Ruan Zhengkun

    2013-01-01

    This paper presents a voltage regulator system for passive UHF RFID transponders, which contains a rectifier, a limiter, and a regulator. The rectifier achieves power by rectifying the incoming RF energy. Due to the huge variation of the rectified voltage, a limiter at the rectifier output is used to clamp the rectified voltage. In this paper, the design of a limiter circuit is discussed in detail, which can provide a stable limiting voltage with low sensitivity to temperature variation and process dispersion. The key aspect of the voltage regulator system is the dynamic bandwidth boosting in the regulator. By sensing the excess current that is bypassed in the limiter during periods of excess energy, the bias current as well as the bandwidth of the regulator are increased, the output supply voltage can recover quickly from line transients during the periods of no RF energy to a full blast of RF energy. This voltage regulator system is implemented in a 0.18 μm CMOS process. (semiconductor integrated circuits)

  9. Experimental research of the impact of the dosing of chemical reagents on the dynamic behavior of regulation system of cycle chemistry

    Science.gov (United States)

    Yegoshina, O. V.; Bolshakova, N. A.

    2017-11-01

    Organization of reliable chemical control for maintaining cycle chemistry is one of the most important problems to be solved at the present time the design and operation of thermal power plants. To maintain optimal parameters of cycle chemistry are used automated chemical control system and regulation system of dosing chemical reagents. Reliability and stability analyzer readings largely determine the reliability of the water cycle chemistry. Now the most common reagents are ammonia, alkali and film-forming amines. In this paper are presented the results of studies of the impact of concentration and composition of chemical reagents for readings stability of automatic analyzers and transients time of control systems for cycles chemistry. Research of the impact of chemical reagents on the dynamic behavior of regulation system for cycle chemistry was conducted at the experimental facility of the Department of thermal power stations of the Moscow Engineering Institute. This experimental facility is model of the work of regulation system for cycle chemistry close to the actual conditions on the energy facilities CHP. Analysis of results of the impact of chemical reagent on the dynamic behavior of ammonia and film forming amines dosing systems showed that the film-forming amines dosing system is more inertia. This emphasizes the transition process of the system, in which a half times longer dosing of ammonia. Results of the study can be used to improve the monitoring systems of water chemical treatment.

  10. Activity-dependent self-regulation of viscous length scales in biological systems

    Science.gov (United States)

    Nandi, Saroj Kumar

    2018-05-01

    The cellular cortex, which is a highly viscous thin cytoplasmic layer just below the cell membrane, controls the cell's mechanical properties, which can be characterized by a hydrodynamic length scale ℓ . Cells actively regulate ℓ via the activity of force-generating molecules, such as myosin II. Here we develop a general theory for such systems through a coarse-grained hydrodynamic approach including activity in the static description of the system providing an experimentally accessible parameter and elucidate the detailed mechanism of how a living system can actively self-regulate its hydrodynamic length scale, controlling the rigidity of the system. Remarkably, we find that ℓ , as a function of activity, behaves universally and roughly inversely proportional to the activity of the system. Our theory rationalizes a number of experimental findings on diverse systems, and comparison of our theory with existing experimental data shows good agreement.

  11. Department of

    African Journals Online (AJOL)

    USER

    2014-10-30

    Oct 30, 2014 ... weight and seed yield of the cowpea varieties showed a significant difference in Sorghum intercrop. Sorghum Plant ... practices, intercropping system continued to dominate the cropping pattern of peasant farmers in Nigeria ...

  12. Departments as Agents of Change

    Science.gov (United States)

    Lagowski, J. J.

    1996-07-01

    Higher education is changing because it has no choice. And, for the most part, outside influences are dictating the processes of change. The more fortunate institutions have had a flat budget during this period, but most have been forced to deal with a declining revenue stream as well. Legislators seem bent on micromanaging state-supported institutions, even as they cut their support. Regulators demand greater institutional accountability. Students and their parents expect more service at lower prices and increased flexibility. Technological advances have dramatically affected the availability and accessibility of extant knowledge. It is no longer a question of whether institutions will change, but rather, who will control the change. Most institutions possess long-standing academic traditions, but these are placed at risk in an increasingly competitive market that holds little sympathy for such traditions and may even see them as obstacles or barriers. As a result, the change agents will undoubtedly have a profound effect on the very nature of academic institutions. From the academic point of view, it would seem prudent to attempt to manage the changes that will inevitably occur. A number of concerned observers, notably the Pew Higher Education Roundtable and the American Association for Higher Education, argue persuasively that the academic department is the logical focus for responding to the current winds of change. Using a marketing metaphor, the academic department has been likened to a "producers' cooperative" of services that consumers seek. Thus, the department should be held accountable for the quality of teaching delivered by its members, for the coherence of its major, for its contributions to the general education curriculum, and for supervising and rewarding its individual faculty members. If departments are to be held accountable, it is surely in their best interest to act in such a way that they are accountable. Expecting academic departments to be

  13. "SAFE" LEVEL OF SOMATIC HEALTH IN INDICATORS REGULATION OF CARDIORESPIRATORY SYSTEM AT YOUNG MEN

    Directory of Open Access Journals (Sweden)

    Alexander P Romanchuk

    2015-12-01

    2Lviv State University Physical Culture The aim of this study was to determine the functional state cardiorespiratory system in males younger with "safe" level of somatic health (LSH. Were examined 104 males aged 20,6 ± 0,9 years, engaged in various sports, and had no existing acute and chronic diseases. The survey was conducted using spiroarteriocardiorhythmography (SACR. It is shown that in all studied systems of regulation, regulation except SBP probably marked differences between persons with "safe" and "low" LSH. At the same time, the comparison of "safe" and "medium" LSH differences relate only to the predominance of sympathetic influences on heart rate, decrease suprasegmental effects on DBP, reducing regulatory influences on spontaneous breath and their high-frequency components, reducing of baroreflex sensitivity and cardiac output. Key words: "safe" level of somatic health, regulation of the cardiorespiratory system.

  14. Asymptotic tracking and disturbance rejection of the blood glucose regulation system.

    Science.gov (United States)

    Ashley, Brandon; Liu, Weijiu

    2017-07-01

    Type 1 diabetes patients need external insulin to maintain blood glucose within a narrow range from 65 to 108 mg/dl (3.6 to 6.0 mmol/l). A mathematical model for the blood glucose regulation is required for integrating a glucose monitoring system into insulin pump technology to form a closed-loop insulin delivery system on the feedback of the blood glucose, the so-called "artificial pancreas". The objective of this paper is to treat the exogenous glucose from food as a glucose disturbance and then develop a closed-loop feedback and feedforward control system for the blood glucose regulation system subject to the exogenous glucose disturbance. For this, a mathematical model for the glucose disturbance is proposed on the basis of experimental data, and then incorporated into an existing blood glucose regulation model. Because all the eigenvalues of the disturbance model have zero real parts, the center manifold theory is used to establish blood glucose regulator equations. We then use their solutions to synthesize a required feedback and feedforward controller to reject the disturbance and asymptotically track a constant glucose reference of 90  mg/dl. Since the regulator equations are nonlinear partial differential equations and usually impossible to solve analytically, a linear approximation solution is obtained. Our numerical simulations show that, under the linear approximate feedback and feedforward controller, the blood glucose asymptotically tracks its desired level of 90 mg/dl approximately. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Personalised Learning Object System Based on Self-Regulated Learning Theories

    Directory of Open Access Journals (Sweden)

    Ali Alharbi

    2014-06-01

    Full Text Available Self-regulated learning has become an important construct in education research in the last few years. Selfregulated learning in its simple form is the learner’s ability to monitor and control the learning process. There is increasing research in the literature on how to support students become more self-regulated learners. However, the advancement in the information technology has led to paradigm changes in the design and development of educational content. The concept of learning object instructional technology has emerged as a result of this shift in educational technology paradigms. This paper presents the results of a study that investigated the potential educational effectiveness of a pedagogical framework based on the self-regulated learning theories to support the design of learning object systems to help computer science students. A prototype learning object system was developed based on the contemporary research on self-regulated learning. The system was educationally evaluated in a quasi-experimental study over two semesters in a core programming languages concepts course. The evaluation revealed that a learning object system that takes into consideration contemporary research on self-regulated learning can be an effective learning environment to support computer science education.

  16. Accuracy of 'My Gut Feeling:' Comparing System 1 to System 2 Decision-Making for Acuity Prediction, Disposition and Diagnosis in an Academic Emergency Department.

    Science.gov (United States)

    Cabrera, Daniel; Thomas, Jonathan F; Wiswell, Jeffrey L; Walston, James M; Anderson, Joel R; Hess, Erik P; Bellolio, M Fernanda

    2015-09-01

    Current cognitive sciences describe decision-making using the dual-process theory, where a System 1 is intuitive and a System 2 decision is hypothetico-deductive. We aim to compare the performance of these systems in determining patient acuity, disposition and diagnosis. Prospective observational study of emergency physicians assessing patients in the emergency department of an academic center. Physicians were provided the patient's chief complaint and vital signs and allowed to observe the patient briefly. They were then asked to predict acuity, final disposition (home, intensive care unit (ICU), non-ICU bed) and diagnosis. A patient was classified as sick by the investigators using previously published objective criteria. We obtained 662 observations from 289 patients. For acuity, the observers had a sensitivity of 73.9% (95% CI [67.7-79.5%]), specificity 83.3% (95% CI [79.5-86.7%]), positive predictive value 70.3% (95% CI [64.1-75.9%]) and negative predictive value 85.7% (95% CI [82.0-88.9%]). For final disposition, the observers made a correct prediction in 80.8% (95% CI [76.1-85.0%]) of the cases. For ICU admission, emergency physicians had a sensitivity of 33.9% (95% CI [22.1-47.4%]) and a specificity of 96.9% (95% CI [94.0-98.7%]). The correct diagnosis was made 54% of the time with the limited data available. System 1 decision-making based on limited information had a sensitivity close to 80% for acuity and disposition prediction, but the performance was lower for predicting ICU admission and diagnosis. System 1 decision-making appears insufficient for final decisions in these domains but likely provides a cognitive framework for System 2 decision-making.

  17. Dual PD Control Regulation with Nonlinear Compensation for a Ball and Plate System

    Directory of Open Access Journals (Sweden)

    Sergio Galvan-Colmenares

    2014-01-01

    Full Text Available The normal proportional derivative (PD control is modified to a new dual form for the regulation of a ball and plate system. First, to analyze this controller, a novel complete nonlinear model of the ball and plate system is obtained. Second, an asymptotic stable dual PD control with a nonlinear compensation is developed. Finally, the experimental results of ball and plate system are provided to verify the effectiveness of the proposed methodology.

  18. A Study to Develop the Optimal Military Inter-Institutional Patient Referral Systems Model for DoD (Department of Defense) Military Medical Region III

    Science.gov (United States)

    1988-05-01

    I rerr syttemn an do wlon t P ontimal military inter-instittiuonal patient referral systems model for DOD Military Medical Region III. A convenience...Dactin- on the Armed Services Medical Regulating Office and Patient Airlift "lc rcsusl.s of :his study indicated that the single largest breakdown...and the requirement to regulate to the closest medical facility with capability to care for the patient . L! / I Ii I i A STUDY TO DEVELOP THE OPTIMAL

  19. Evaluation of a treatment system wastewater prebeneficiado of coffee (Coffea arabica implemented in the community Carmen Pampa province of Nor Yungas of La Paz Department

    Directory of Open Access Journals (Sweden)

    Álvarez Javier

    2011-08-01

    Full Text Available This research was conducted in prebeneficiadora coffee plant of UAC-CP, located in the community of Carmen Pampa, Coroico Municipality, Nor Yungas of La Paz department. The objective was to determine the efficiency of wastewater treatment prebeneficiado coffee because it is not known to be effective in reducing the level of contamination of treated wastewater, and according to the results to correct and / or validate directly model system in place. For their study was established seven sampling points within the system of treatment and four replications were made at different times and with different amounts of coffee cherry. We evaluated the parameters of temperature, pH, settleable solids, total suspended solids, fixed and volatile, biochemical oxygen demand, chemical oxygen demand and dissolved oxygen. The temperature of wastewater entering the system has recorded 16.5 o C, increasing during the treatment process at 17.5 °C and record the output is 16.5 ºC. The pH increased from 4.51 to 6.04 which occurred at the last two gaps oxygenation and not in the neutralization tank. Settleable solids (SS increased from 0.1 mg / L to 0.15 mg / L, which was recorded at the lakes of oxygen, is attributed to the drag of fine gravel. Total suspended solids (TSS have been reduced from 1927.5 mg / L to 299 mg / L gradually throughout the treatment process. Fixed suspended solids (SSF were reduced from 137.5 mg / L to 58.5 mg / L. Volatile suspended solids (VSS were reduced from 1790 mg / L to 240.5 mg / L. Biochemical oxygen demand (BOD was reduced from 6102.5 mg O2 / L to 1245 mg O2 / L. The chemical oxygen demand (COD was reduced from 9800 mg O2 / L to 1658.75 mg O2 / L. Dissolved oxygen (DO increased from 0 to 2.4 mg O2 / L, in the last two gaps in oxygenation, due to the reduction of solids and chemical oxygen demand and biochemical oxygen. Of the nine parameters measured, six meet the maximum permissible values for download in source receptor (stream

  20. 41 CFR 128-1.101 - Justice Property Management Regulations.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Justice Property Management Regulations. 128-1.101 Section 128-1.101 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF JUSTICE 1-INTRODUCTION 1.1-Regulation System § 128-1...

  1. Total System Performance Assessment Sensitivity Analyses for Final Nuclear Regulatory Commission Regulations

    International Nuclear Information System (INIS)

    Bechtel SAIC Company

    2001-01-01

    This Letter Report presents the results of supplemental evaluations and analyses designed to assess long-term performance of the potential repository at Yucca Mountain. The evaluations were developed in the context of the Nuclear Regulatory Commission (NRC) final public regulation, or rule, 10 CFR Part 63 (66 FR 55732 [DIRS 156671]), which was issued on November 2, 2001. This Letter Report addresses the issues identified in the Department of Energy (DOE) technical direction letter dated October 2, 2001 (Adams 2001 [DIRS 156708]). The main objective of this Letter Report is to evaluate performance of the potential Yucca Mountain repository using assumptions consistent with performance-assessment-related provisions of 10 CFR Part 63. The incorporation of the final Environmental Protection Agency (EPA) standard, 40 CFR Part 197 (66 FR 32074 [DIRS 155216]), and the analysis of the effect of the 40 CFR Part 197 EPA final rule on long-term repository performance are presented in the Total System Performance Assessment--Analyses for Disposal of Commercial and DOE Waste Inventories at Yucca Mountain--Input to Final Environmental Impact Statement and Site Suitability Evaluation (BSC 2001 [DIRS 156460]), referred to hereafter as the FEIS/SSE Letter Report. The Total System Performance Assessment (TSPA) analyses conducted and documented prior to promulgation of the NRC final rule 10 CFR Part 63 (66 FR 55732 [DIRS 156671]), were based on the NRC proposed rule (64 FR 8640 [DIRS 101680]). Slight differences exist between the NRC's proposed and final rules which were not within the scope of the FEIS/SSE Letter Report (BSC 2001 [DIRS 156460]), the Preliminary Site Suitability Evaluation (PSSE) (DOE 2001 [DIRS 155743]), and supporting documents for these reports. These differences include (1) the possible treatment of ''unlikely'' features, events and processes (FEPs) in evaluation of both the groundwater protection standard and the human-intrusion scenario of the individual

  2. Nutritional components regulate the gut immune system and its association with intestinal immune disease development.

    Science.gov (United States)

    Lamichhane, Aayam; Kiyono, Hiroshi; Kunisawa, Jun

    2013-12-01

    The gut is equipped with a unique immune system for maintaining immunological homeostasis, and its functional immune disruption can result in the development of immune diseases such as food allergy and intestinal inflammation. Accumulating evidence has demonstrated that nutritional components play an important role in the regulation of gut immune responses and also in the development of intestinal immune diseases. In this review, we focus on the immunological functions of lipids, vitamins, and nucleotides in the regulation of the intestinal immune system and as potential targets for the control of intestinal immune diseases. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  3. A scheme for regulating toxic substances to water quality of Chamsil upstream water system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Suk; Kim, Jee Hoon [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    This study asserts to reflect a concept of toxicity thoroughly in the present water quality concept. It presents an appropriate solution to control toxic substances flowing into the Chamsil upstream water system. Although a regulation of toxic substances into major rivers in Korea other than Han river is also required urgently, it will be studied in future. It is expected that this study on Chamsil upstream would be a cornerstone for establishing a national regulation policy of toxic substances into water system. 28 refs., 1 fig., 36 tabs.

  4. Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia coli

    OpenAIRE

    Suzuki, Kazushi; 鈴木, 一史

    2007-01-01

    In many species of bacteria, the Csr (carbon storage regulator) global regulatory system coordinates the expression of various genes. In Escherichia coli, the central component of this system, CsrA, is a RNA-binding protein. The CsrA is a homodimer and binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two small non-coding RNAs, CsrB and CsrC. These RNAs contain multiple CsrA-binding sequences and act by sequestering CsrA. In thi...

  5. The organisation of work and systems of labour market regulation and social protection

    DEFF Research Database (Denmark)

    Lorenz, Edward; Lundvall, Bengt-Åke

    2011-01-01

    The paper demonstrates on the basis of date from 15 European countries that there is a close link between the form of labour market regulation and the systems of social protection on the one hand and modes of work organisation and learning on the other hand.......The paper demonstrates on the basis of date from 15 European countries that there is a close link between the form of labour market regulation and the systems of social protection on the one hand and modes of work organisation and learning on the other hand....

  6. [Digital imaging system are rapidly introduced in Swedish departments of radiography. This calls for new strategic planning].

    Science.gov (United States)

    Laurin, S; Norberg, K A

    2000-10-11

    Diagnostic radiology in Sweden is changing rapidly to digital (filmless) technique. The advantages are more rapid delivery of radiologic service, better working conditions and less negative effects on the environment. Teleradiology is also facilitated. The Swedish Board of Health and Welfare has investigated the speed with which this change is taking place. In 1998, 26 of the 118 departments of diagnostic radiology had already turned digital; it is estimated that in the near future at least five departments will become fully digital each year. For planning purposes, less emphasis should be put on the supply of radiographic film, and more on telecommunications, computer hardware and digital storage.

  7. Characterizing complexity in socio-technical systems: a case study of a SAMU Medical Regulation Center.

    Science.gov (United States)

    Righi, Angela Weber; Wachs, Priscila; Saurin, Tarcísio Abreu

    2012-01-01

    Complexity theory has been adopted by a number of studies as a benchmark to investigate the performance of socio-technical systems, especially those that are characterized by relevant cognitive work. However, there is little guidance on how to assess, systematically, the extent to which a system is complex. The main objective of this study is to carry out a systematic analysis of a SAMU (Mobile Emergency Medical Service) Medical Regulation Center in Brazil, based on the core characteristics of complex systems presented by previous studies. The assessment was based on direct observations and nine interviews: three of them with regulator of emergencies medical doctor, three with radio operators and three with telephone attendants. The results indicated that, to a great extent, the core characteristics of complexity are magnified) due to basic shortcomings in the design of the work system. Thus, some recommendations are put forward with a view to reducing unnecessary complexity that hinders the performance of the socio-technical system.

  8. Department of Energy low-level radioactive waste disposal concepts

    International Nuclear Information System (INIS)

    Ozaki, C.; Page, L.; Morreale, B.; Owens, C.

    1990-01-01

    The Department of Energy manages its low-level waste (LLW), regulated by DOE Order 5820.2A by using an overall systems approach. This systems approach provides an improved and consistent management system for all DOE LLW waste, from generation to disposal. This paper outlines six basic disposal concepts used in the systems approach, discusses issues associated with each of the concepts, and outlines both present and future disposal concepts used at six DOE sites

  9. Experience in adjusting of the level regulation system of steam generators of the Rovno NPP

    International Nuclear Information System (INIS)

    Patselyuk, S.N.; Sokolov, A.G.; Kazakov, V.I.; Dorosh, Yu.A.

    1984-01-01

    A system of feed water level control in steam generators at the Rovno NPP with WWER-440 reactors which comprises start-up as well as main regulators is described. The start-up regulator (single-pulsed with a signal by the level) keeps the level in the steam generator at loadings up to 30% of the nominal reactor power Nsub(nom.) The main regulator is connected in the three-pulsed circuit and it receives signals by steam and water flow rate and by the level in the steam generator. The main regulator has been started only at loadings above 40% Nsub(nom.). After reconstruction it was used in the 15-100% Nsub(nom.) range. Characteristics of the level control system in the steam generator at perturbations intoduced by the main circulating pump (MCP) and turbine disconnection as well as change in feed water flow rate have been studied. The studies have revealed that the system ensures necessary quality of control in stationary modes. The system operates stably at perturbations of feed water flow rate up to 50% Nsub(nom.). Perturbations by MCP connections and disconnections is most difficult for control system

  10. A REVIEW OF FINANCIAL REGULATIONS TO AVOID THE NATIONALISATION OF LOSSES IN THE BANKING SYSTEM

    Directory of Open Access Journals (Sweden)

    SORANA VĂTAVU

    2011-01-01

    Full Text Available This article investigates the regulations which should be applied in the financial system in order to minimize the losses. The subject is based on the banking policy of “privatisation of profits and nationalisation of losses” and it is debated mainly from trade articles point of view. Even when taxpayers do not agree, governments choose either to bailout influential banks or to cover their losses with a deposit insurance. Banks would take advantage of any opportunity to increase earnings, even in the insolvency stage, and thus certain regulations and limitations must be provided to minimize the moral hazard occurred. The most important problem that deepens financial regressions relates to the losses spillover effect on the worldwide economy, and although a perfect global banking model cannot be implemented, the paper suggests regulations which improve the financial systems.

  11. From early family systems to internalizing symptoms: The role of emotion regulation and peer relations.

    Science.gov (United States)

    Lindblom, Jallu; Vänskä, Mervi; Flykt, Marjo; Tolvanen, Asko; Tiitinen, Aila; Tulppala, Maija; Punamäki, Raija-Leena

    2017-04-01

    Research has demonstrated the importance of early family characteristics, such as the quality of caregiving, on children's later mental health. Information is, however, needed about the role of more holistic family systems and specific child-related socioemotional mechanisms. In this study, we conceptualize families as dynamic family system types, consisting of both marital and parenting trajectories over the transition to parenthood. First, we examine how early family system types predict children's anxiety, depression, peer exclusion, and emotion regulation. Second, we test whether couples' infertility history and other family related contextual factors moderate the effects of family system types on child outcomes. Third, we test whether children's emotion regulation and peer exclusion mediate the effects of family system types on anxiety and depression. The participants were 452 families representing cohesive, distant, authoritative, enmeshed, and discrepant family types, identified on the basis of relationship autonomy and intimacy from pregnancy to the child's age of 2 and 12 months. Children's anxiety, depression, emotion regulation, and peer exclusion were assessed at the age of 7-8 years. Structural equation modeling showed that distant, enmeshed, and discrepant families similarly predicted children's heightened anxiety and depression. Infertility history, parental education, and parity moderated the associations between certain family system types and child outcomes. Finally, emotion regulation, but not peer exclusion, was a common mediating mechanism between distant and enmeshed families and children's depression. The results emphasize the importance of early family environments on children's emotion regulation development and internalizing psychopathology. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  12. The advancement of regulation fee, budget system, and set-up time management

    Energy Technology Data Exchange (ETDEWEB)

    Jung, J. S.; Choi, E. S.; Cho, J. I.; Jung, S. C.; Lee, J. H. [Caleb and Company, Seoul (Korea, Republic of)

    2001-07-15

    Analyze the government's charging fee amendment and suggest the national regulation fee system. Suggest the future business portfolio based in the current business analysis. Design the advanced budget code structure, the performance management of the project budget and the survice level agreement between divisions. Develop the time management and the methodology of the standard man-hour calculation.

  13. Energy Management Systems and tertiary regulation in hierarchical control architectures for islanded micro-grids

    DEFF Research Database (Denmark)

    Sanseverino, Eleonora Riva; Di Silvestre, Maria Luisa; Quang, Ninh Nguyen

    2015-01-01

    In this paper, the structure of the highest level of a hierarchical control architecture for micro-grids is proposed. Such structure includes two sub-levels: the Energy Management System, EMS, and the tertiary regulation. The first devoted to energy resources allocation in each time slot based...

  14. Customizable Computer-Based Interaction Analysis for Coaching and Self-Regulation in Synchronous CSCL Systems

    Science.gov (United States)

    Lonchamp, Jacques

    2010-01-01

    Computer-based interaction analysis (IA) is an automatic process that aims at understanding a computer-mediated activity. In a CSCL system, computer-based IA can provide information directly to learners for self-assessment and regulation and to tutors for coaching support. This article proposes a customizable computer-based IA approach for a…

  15. 75 FR 391 - Medical Device Quality System Regulation Educational Forum on Risk Management Through the Product...

    Science.gov (United States)

    2010-01-05

    ...] Medical Device Quality System Regulation Educational Forum on Risk Management Through the Product Life... on Risk Management through the Product Life Cycle.'' This public workshop is intended to provide... discussed at the workshop: (1) Standards and guidance, (2) risk management in design, (3) risk management in...

  16. How Do Students Regulate their Learning of Complex Systems with Hypermedia?.

    Science.gov (United States)

    Azevedo, Roger; Seibert, Diane; Guthrie, John T.; Cromley, Jennifer G.; Wang, Huei-yu; Tron, Myriam

    This study examined the role of different goal-setting instructional interventions in facilitating students' shift to more sophisticated mental models of the circulatory system as indicated by both performance and process data. Researchers adopted the information processing model of self-regulated learning of P. Winne and colleagues (1998, 2001)…

  17. Capturing the Family Context of Emotion Regulation: A Family Systems Model Comparison Approach

    Science.gov (United States)

    Fosco, Gregory M.; Grych, John H.

    2013-01-01

    Several dimensions of family functioning are recognized as formative influences on children's emotion regulation. Historically, they have been studied separately, limiting our ability to understand how they function within the family system. The present investigation tested models including family emotional climate, interparental conflict, and…

  18. Systems analysis of multiple regulator perturbations allows discovery of virulence factors in Salmonella

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hyunjin; Ansong, Charles; McDermott, Jason E.; Gritsenko, Marina A.; Smith, Richard D.; Heffron, Fred; Adkins, Joshua N.

    2011-06-28

    Background: Systemic bacterial infections are highly regulated and complex processes that are orchestrated by numerous virulence factors. Genes that are coordinately controlled by the set of regulators required for systemic infection are potentially required for pathogenicity. Results: In this study we present a systems biology approach in which sample-matched multi-omic measurements of fourteen virulence-essential regulator mutants were coupled with computational network analysis to efficiently identify Salmonella virulence factors. Immunoblot experiments verified network-predicted virulence factors and a subset was determined to be secreted into the host cytoplasm, suggesting that they are virulence factors directly interacting with host cellular components. Two of these, SrfN and PagK2, were required for full mouse virulence and were shown to be translocated independent of either of the type III secretion systems in Salmonella or the type III injectisome-related flagellar mechanism. Conclusions: Integrating multi-omic datasets from Salmonella mutants lacking virulence regulators not only identified novel virulence factors but also defined a new class of translocated effectors involved in pathogenesis. The success of this strategy at discovery of known and novel virulence factors suggests that the approach may have applicability for other bacterial pathogens.

  19. Control mechanisms for battery energy storage system performing primary frequency regulation and self-consumption optimization

    NARCIS (Netherlands)

    Pliatskas Stylianidis, A.

    2016-01-01

    This report contains the design of a model for the integration of a battery energy system in a household level and its use for primary frequency regulation and self-consumption optimization. The main goal of this project was to investigate what are the possible applications and the most suitable for

  20. Self-regulating insulin delivery systems I. Synthesis and characterization of glycosylated insulin

    NARCIS (Netherlands)

    Jeong, Seo Young; Kim, Sung Wan; Eenink, Martinus J.D.; Feijen, Jan

    1984-01-01

    A design for a self-regulating insulin delivery system based on the competitive binding of glucose and glycosylated insulin to the lectin Concanavalin A is proposed. A differnt approach to diabetes therapy is the attempt to effect a permanent cure of the disease by supplementing the patient's