WorldWideScience

Sample records for regulations respecting administration

  1. RESPECT

    DEFF Research Database (Denmark)

    Teyeb, Oumer; Boussif, Malek; Sørensen, Troels Bundgaard

    2005-01-01

    the performance from an end-2-end (E2E), user-perceived Quality Of Service (QoS) point of view. In this paper, the design and implementation of RESPECT, an easily configurable network emulator is described. RESPECT was originally geared towards Universal Mobile Communications System (UMTS) networks, but thanks...... to its modular and scalable design, it is being extended for generic heterogeneous networks. Using RESPECT, QoS studies can be carried out to study the behavior of different services in different network conditions, identify generalized service dependent performance metrics for already existing services...

  2. Administrative Jurisdiction in NMa decisions with respect to Energy Jurisdiction

    International Nuclear Information System (INIS)

    Algera, W.T.

    2011-01-01

    In 2010 decisions were made in 14 energy issues with respect to decisions of the Netherlands Competition Authority NMa. All the decisions were done by Court of Appeal for trade and industry. The decisions touch upon a broad spectrum of subjects and comprise several procedures. They are discussed and commented in this thematic annual analysis. [nl

  3. 40 CFR 29.5 - What is the Administrator's obligation with respect to Federal interagency coordination?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false What is the Administrator's obligation with respect to Federal interagency coordination? 29.5 Section 29.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND...

  4. 75 FR 31678 - Export Administration Regulations: Technical Corrections

    Science.gov (United States)

    2010-06-04

    ... and 774 [Docket No. 0907271167-91198-01] RIN 0694-AE69 Export Administration Regulations: Technical... clarifies language concerning the de minimis provisions of the Export Administration Regulations and certain... Items The Export Administration Regulations (EAR) generally do not apply to items that were made and are...

  5. 78 FR 29245 - U.S. General Services Administration Federal Property Management Regulations; Administrative Wage...

    Science.gov (United States)

    2013-05-20

    ... Federal Property Management Regulations; Administrative Wage Garnishment AGENCY: Office of the Chief... the U.S. General Services Administration Property Management Regulation (GSPMR) to remove information... Administrative Wage Garnishment Code of Federal Regulations (CFR) Parts affected are as follows: 41 CFR part 105...

  6. Legal principles of regulatory administration and nuclear safety regulation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyeong Hui; Cheong, Sang Kee [Hannam Univ., Taejon (Korea, Republic of)

    2000-12-15

    This research presents a critical analysis and evaluation of principles of administrative laws in order to provide framework of structural reform on the nuclear safety regulation system. The focus of this analysis and evaluation is centered around the area of origin of regulatory administrative laws; authorities of regulation; procedures of regulatory actions; regulatory enforcement; and administrative relief system. In chapter 2 the concept of regulatory administration is analysed. Chapter 3 identifies the origin of regulatory administration and the principles of administration laws. It also examines legal nature of the nuclear safety standard. In relation to regulatory authorities. Chapter 4 identifies role and responsibility of administration authorities and institutions. It also examines fundamental principles of delegation of power. Then the chapter discusses the nuclear safety regulation authorities and their roles and responsibilities. Chapter 5 classifies and examines regulatory administration actions. Chapter 6 evaluates enforcement measure for effectiveness of regulation. Finally, chapter 7 discusses the administrative relief system for reviewing unreasonable regulatory acts.

  7. 20 CFR 655.1205 - What is the Administrator's responsibility with respect to complaints and investigations?

    Science.gov (United States)

    2010-04-01

    ... AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY EMPLOYMENT OF FOREIGN WORKERS IN THE UNITED... determination to the interested parties and shall inform them of the opportunity for a hearing pursuant to § 655...

  8. 75 FR 33682 - Export Administration Regulations; Technical Amendments

    Science.gov (United States)

    2010-06-15

    ...-01] RIN 0694-AE93 Export Administration Regulations; Technical Amendments AGENCY: Bureau of Industry... Bureau of Industry and Security (BIS) makes a technical amendment to the Export Administration... review of final decisions and orders issued in BIS export control administrative enforcement proceedings...

  9. 20 CFR 200.7 - Assessment or waiver of interest, penalties, and administrative costs with respect to collection...

    Science.gov (United States)

    2010-04-01

    ... any of the Acts which the Board administers. (b)(1) Simple interest shall be assessed once a month on... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Assessment or waiver of interest, penalties... waiver of interest, penalties, and administrative costs with respect to collection of certain debts. (a...

  10. LEGAL REGULATION OF ADMINISTRATIVE CONTRACTS IN BOSNIA AND HERZEGOVINA

    Directory of Open Access Journals (Sweden)

    Edina Šehrić

    2016-09-01

    Full Text Available The institute of administrative contract was mentioned for the first time in the legislation of our country in the Preliminary Draft to the Law on Amandments of the Law on Administrative Procedure of Bosnia and Herzegovina from 2012. Although insufficiently, the first step is made towards fullfillment of the reform requirements in the area of admisitrative procedure on the way to the European integration and in accordance with the changed role of administration and the need for improvement of cooperation between the administration and citizens, or legal entities. In Bosnia and Herzegovina there is still no general legal regulation of administrative contracts, but administrative contracts are subjects to specific laws and as such already exist in the legal system. After some introductory remarks, the paper deals with the concept and characteristics of administrative contracts, and also presents legal regulation of administrative contracts highlighting their specificities and differences in relation to private law contracts. The importance of general legal norm governing administrative contracts is especially emphasized, as well as their importance for reform processes in our country. Accordingly, the importance of introducing a complaint as a legal remedy that a client can use if the public authority fails to meet contractual obligations is pointed out, but also the possibility of judicial protection in case of legal dispute.

  11. School menus in Santa Catarina: Evaluation with respect to the National School Food Program regulations

    Directory of Open Access Journals (Sweden)

    Glenda Marreira Vidal

    2015-06-01

    Full Text Available OBJECTIVE: To assess compliance of school menu planning with the National School Food Program's regulations. METHODS: This cross-sectional study analyzed 133 menus for 542 schools in 49 municipalities of the state of Santa Catarina. The menus were assessed according to the National School Food Program's regulations, the "Dietary Guidelines for the Brazilian Population" and the "Qualitative Evaluation of Menu Components for Schools". The data were analyzed by descriptive statistics. RESULTS: Nearly all (98.5% municipalities met the requirement of technical responsibility for menu development and 81.0% acquired foods from family farms. The menus contained fruits (87.2% and non-starchy vegetables (94.0%, but the frequencies of fruits and non-starchy vegetables were smaller than two to three times a week. The most common high-sodium and high-fat foods were commercially processed meats (53.0%, but their frequency was smaller than once a week. Likewise, the frequencies of beverages (natural fruit juice, coffee, and tea were smaller than once a week. Most menus (85.1% repeated foods during the week, and only 3.0% of the menus listed organic foods. CONCLUSION: Some school menus from Santa Catarina need to be revised with respect to the frequency of fruits and non-starchy vegetables, high-sugar foods, high-sodium foods, and high-fat foods, and need to increase food diversity and variety.

  12. 75 FR 33989 - Export Administration Regulations: Technical Corrections

    Science.gov (United States)

    2010-06-16

    ... 0694-AE69 Export Administration Regulations: Technical Corrections AGENCY: Bureau of Industry and... section of Export Control Classification Number 2B001 and the other is in the Technical Note on Adjusted... language regarding certain performance criteria of turning machines covered by Export Control...

  13. MEB 2013, Regulation for Administrator Assignment and Relocation Based On the Opinions of Administrators

    Directory of Open Access Journals (Sweden)

    Soner DOĞAN

    2014-04-01

    Full Text Available In this study; it is aimed to determine the opinions of the institution managers concerning the Regulation for Administrator Assignment and Relocation dated February 28, 2013, the scoring criteria in the regulation and the disturbances experienced in the application process of the regulation. The study is carried out in accordance with the phenomenological pattern through qualitative research methods. The participants were determined with the criterion sampling method which is one of the purposeful sampling methods. The study group of the research is composed of the eight managers serving in a province. In the study, a semi-structured interview form was used as data collection tool. In the interpretation process of the interviews, the inductive descriptive analysis, the content analysis and the constant comparison technique were used. Three main themes have come out regarding the result of the data analysis process of assigning the administrators, the combining of the different types of institutions and the application of the forced relocation.

  14. Care for the person, protection of health and respect for the will of the patient in Italy: support administration as a tool to jointly promote health and respect for autonomy in incompetent patients

    Directory of Open Access Journals (Sweden)

    Paola Delbon

    2014-12-01

    Full Text Available In Italy, advance health care directives are a subject of considerable debate in both legal theory and practice. This debate focuses in partic- ular not only on the appropriateness of approving ad hoc statutory reg- ulations but also on the extent to which similar advance indications of a person’s wishes are applicable under the existing legal system, albeit in the absence of a law regulating them. The authors of this paper con- sider, in particular, guidelines relating to the possible use of the mech- anism of support administration (amministrazione di sostegno (Law No. 6/2004 as a procedure to be used for the legal recognition of advance health care directives, particularly in the light of the legal pro- vision for the possible designation in advance of a support administra- tor by a beneficiary in anticipation of an eventual situation of incapac- ity. This underlines how the concept of health does not only exist in the abstract, but must be measured in relation to the particular patient in the particular situation and how beneficence and respect for auton- omy are both essential elements in the choices aimed at promoting the health and the wellbeing of its citizens.

  15. 78 FR 59165 - Orders: Information Reporting With Respect to Stress Testing of Regulated Entities

    Science.gov (United States)

    2013-09-26

    ... Instructions and Guidance is effective on October 28, 2013. FOR FURTHER INFORMATION CONTACT: Naa Awaa Tagoe, Senior Associate Director, Office of Financial Analysis, Modeling and Simulations, (202) 649-3140... Guidance accompanying each Order provides to the regulated entities general advice concerning the content...

  16. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Science.gov (United States)

    2010-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware River...

  17. Conflict and cooperation with respect to European natural-gas regulations

    International Nuclear Information System (INIS)

    Austvik, O.G.

    2003-01-01

    Significant economies of scale and scope in the European gas industry make many transmission and local distribution companies natural monopolies in the markets in which they operate. Often, this gives them a strong market power and they experience little competitive pressure. Hence public interventions into the functioning of the market, as seen under the initiatives taken by the European Commission, such as the 'Gas Directive' occur. This paper discusses a game between the public authority and the transporters, where various levels of conflict and cooperation will influence how far regulations will go and how they will be designed. (author)

  18. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Science.gov (United States)

    2010-01-01

    ... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL INFORMATION AND OVERVIEW OF THE CHEMICAL WEAPONS CONVENTION REGULATIONS (CWCR) § 710.6 Relationship between the Chemical Weapons Convention Regulations and the Export Administration Regulations, the International...

  19. 26 CFR 48.4061-1 - Temporary regulations with respect to floor stock refunds or credits on cement mixers.

    Science.gov (United States)

    2010-04-01

    ... stock refunds or credits on cement mixers. 48.4061-1 Section 48.4061-1 Internal Revenue INTERNAL REVENUE... § 48.4061-1 Temporary regulations with respect to floor stock refunds or credits on cement mixers. (a... of tax on motor vehicles) on the sale of a cement mixer after June 30, 1968, and before January 1...

  20. Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol

    Directory of Open Access Journals (Sweden)

    Chris Pickering

    2010-06-01

    Full Text Available Executive dysfunction is a common symptom among alcohol-dependent individuals. Phencyclidine (PCP injection induces dysfunction in the prefrontal cortex of animals but little is known about how PCP affects the response to ethanol. Using the in vivo microdialysis technique in male Wistar rats, we investigated how systemic injection of 5 mg/kg PCP would affect the dopamine release induced by local infusion of 300 mM ethanol into the nucleus accumbens. PCP given 60 min before ethanol entirely blocked ethanol-induced dopamine release. However, when ethanol was administered 60 min before PCP, both drugs induced dopamine release and PCP’s effect was potentiated by ethanol (180% increase vs 150%. To test the role of prefrontal cortex dysfunction in ethanol reinforcement, animals were pre-treated for 5 days with 2.58 mg/kg PCP according to previously used ‘PFC hypofunction protocols’. This, however, did not change the relative response to PCP or ethanol compared to saline-treated controls. qPCR illustrated that this PCP dose did not significantly change expression of glucose transporters Glut1 (SLC2A1 or Glut3 (SLC2A3, monocarboxylate transporter MCT2 (SLC16A7, glutamate transporters GLT-1 (SLC1A2 or GLAST (SLC1A3, the immediate early gene Arc (Arg3.1 or GABAergic neuron markers GAT-1 (SLC6A1 and parvalbumin. Therefore, we concluded that PCP at a dose of 2.58 mg/kg for 5 days did not induce hypofunction in Wistar rats. However, PCP and ethanol do have overlapping mechanisms of action and these drugs differentially affect mesolimbic dopaminergic transmission depending on the order of administration.

  1. 41 CFR 105-1.101 - General Services Administration Property Management Regulations.

    Science.gov (United States)

    2010-07-01

    ...-INTRODUCTION 1.1-Regulations System § 105-1.101 General Services Administration Property Management Regulations... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General Services Administration Property Management Regulations. 105-1.101 Section 105-1.101 Public Contracts and Property...

  2. 77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2012-02-24

    ...D published an initial proposed rule for Business Systems-- Definition and Administration (DFARS... the definition and administration of contractor business systems as follows: A. Contractor business..., 245, and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems...

  3. 29 CFR 790.17 - “Administrative regulation, order, ruling, approval, or interpretation.”

    Science.gov (United States)

    2010-07-01

    ... 1938 Defense of Good Faith Reliance on Administrative Regulations, Etc. § 790.17 “Administrative... in regard to their function under the “good faith” defense. Accordingly, no useful purpose would be... that where the employer's good faith reliance on a regulation, order, ruling, approval or...

  4. 76 FR 77115 - Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding...

    Science.gov (United States)

    2011-12-12

    ..., and 774 [Docket No. 110627356-1475-01] RIN 0694-AF29 Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding of the Provisions That Implement the Comprehensive U.S... rule, the Bureau of Industry and Security (BIS) amends the Export Administration Regulations (EAR) by...

  5. 77 FR 9659 - General Services Administration Acquisition Regulation; Information Collection; GSA Mentor...

    Science.gov (United States)

    2012-02-17

    ... Services Administration Acquisition Regulation; Information Collection; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration...- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations.gov : http...

  6. 77 FR 31016 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor...

    Science.gov (United States)

    2012-05-24

    ... Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration... Collection 3090- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations...

  7. 76 FR 28855 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration

    Science.gov (United States)

    2011-05-18

    ...; Business Systems-- Definition and Administration; Interim Rule #0;#0;Federal Register / Vol. 76 , No. 96...-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration... an initial proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038...

  8. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ...; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD... collection requirement concerning cost accounting standards administration. A notice was published in the...- 0129, Cost Accounting Standards Administration by any of the following methods: Regulations.gov : http...

  9. On Administrative Regulation Mode of Surrogacy%代孕的行政规制模式研究

    Institute of Scientific and Technical Information of China (English)

    刘长秋

    2013-01-01

    The choice of administrative regulation mode of surrogacy directly influences, and even decides, the effect of surrogacy regulation. At present, there are mainly three administrative regulation modes of surrogacy worldwide, which are completely prohibited mode, limited open mode and non-uniformly regulated mode. The completely prohibited mode adopted by China’s current administrative regulation concerning surrogacy doesn’t go against the basic principle of administrative regulation, and on the contrary, it is a reasonable administrative regulation mode respecting more of humanity, being fully conforming to China’s national conditions. However, out of the need to regulate surrogacy more effectively, China’s current surrogacy regulation needs to be further improved in system design.%代孕行政规制模式的选择,直接影响甚至决定着代孕规制的效果。目前,世界范围内主要有完全禁止型、有限开放型和非统一规制型三种代孕行政规制模式。我国现行行政规章对代孕所采取的完全禁止模式,并不违背行政规制的基本原则,相反,它是一种更尊重人性的且完全符合我国国情的合理的行政规制模式。然而,出于更有效规制代孕之需要,我国现行代孕规制在制度设计上还需要进一步完善。

  10. Efficiency defense and administrative fuzziness in merger regulation

    Czech Academy of Sciences Publication Activity Database

    Medvedev, Andrei

    -, č. 234 (2004), s. 1-42 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z7085904 Keywords : merger regulation * efficiency defense Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp234.pdf

  11. Local Commune Administration as a Regulator of the Local Water Supply and Sewage Disposal Services Market

    OpenAIRE

    Małysko, Jacek

    2012-01-01

    In this article the author discusses problems related to the regulation of water and sewage disposal services market. In the beginning he describes the processes of water supply and sewage disposal taken by the local commune administration as a natural monopoly. Next he characterizes the structure of this market in Poland. Then he presents the role of local commune administration as a regulator. The author concludes by evaluating the existing Polish system of regulating wate...

  12. Environmental impact statement law and environmental impact statement administration regulation

    International Nuclear Information System (INIS)

    Feldmann, F.J.

    1991-01-01

    The contribution does not deal with the question - as might be suggested by the heading - that the execution of the environmental impact statement law might be uncertain if there are no further accompanying legal transformatory acts. Putting the environmental impact statements into action is concerned in partiuclar with procedural provisions regarding the Federal Act on Protection against Nuisances and the Atomic Energy Act. The author deals with aspects of the environmental impact statement law and the state-of-the-art achieved so far. He also deals with legislative intent, with further points of putting the law into practice, i.e. the information requirements in the administrative provisions and the integrating aspect, the amalgamating aspect, the requirements made on the state of the environment, and the significance of administrative provisions. Also treated are legal procedures in the Federal Laender and on an international level. (RST) [de

  13. Curli Fibers Are Highly Conserved between Salmonella typhimurium and Escherichia coli with Respect to Operon Structure and Regulation

    Science.gov (United States)

    Römling, Ute; Bian, Zhao; Hammar, Mårten; Sierralta, Walter D.; Normark, Staffan

    1998-01-01

    Mouse-virulent Salmonella typhimurium strains SR-11 and ATCC 14028-1s express curli fibers, thin aggregative fibers, at ambient temperature on plates as judged by Western blot analysis and electron microscopy. Concomitantly with curli expression, cells develop a rough and dry colony morphology and bind the dye Congo red (called the rdar morphotype). Cloning and characterization of the two divergently transcribed operons required for curli biogenesis, csgBA(C) and csgDEFG, from S. typhimurium SR-11 revealed the same gene order and flanking genes as in Escherichia coli. The divergence of the curli region between S. typhimurium and E. coli at the nucleotide level is above average (22.4%). However, a high level of conservation at the protein level, which ranged from 86% amino acid homology for the fiber subunit CsgA to 99% homology for the lipoprotein CsgG, implies functional constraints on the gene products. Consequently, S. typhimurium genes on low-copy-number plasmids were able to complement respective E. coli mutants, although not always to wild-type levels. rpoS and ompR are required for transcriptional activation of (at least) the csgD promoter. The high degree of conservation at the protein level and the identical regulation patterns in E. coli and S. typhimurium suggest similar roles of curli fibers in the same ecological niche in the two species. PMID:9457880

  14. Radiopharmaceutical regulation and Food and Drug Administration policy.

    Science.gov (United States)

    Rotman, M; Laven, D; Levine, G

    1996-04-01

    The regulatory policy of the Food and Drug Administration (FDA) on radiopharmaceuticals flows from a rigid, traditional, drug-like interpretation of the FDC Act on the licensing of radiopharmaceuticals. This contributes to significant delays in the drug-approval process for radiopharmaceuticals, which are very costly to the nuclear medicine community and the American public. It seems that radiopharmaceuticals would be better characterized as molecular devices. Good generic rule-making principles include: use of a risk/benefit/cost analysis; intent based on sound science; performance standards prepared by outside experts; a definite need shown by the regulatory agency; to live with the consequences of any erroneous cost estimates; and design individual credential requirements so that additional training results in enhanced professional responsibility. When these common elements are applied to current FDA policy, it seems that the agency is out of sync with the stated goals for revitalizing federal regulatory policies as deemed necessary by the Clinton administration. Recent FDA rulings on positron-emission tomography, Patient Package inserts, and on medical device service accentuate the degree of such asynchronization. Radiopharmaceutical review and licensing flexibility could be dramatically improved by excluding radiopharmaceuticals from the drug category and reviewing them as separate entities. This new category would take into account their excellent record of safety and their lack of pharmacological action. Additionally, their evaluation of efficacy should be based on their ability to provide useful scintiphotos, data, or responses of the physiological system it portends to image, quantitate, or describe. To accomplish the goal of transforming the FDA's rigid, prescriptive policy into a streamlined flexible performance-based policy, the Council on Radionuclides and Radiopharmaceuticals proposal has been presented. In addition, it is suggested that the United

  15. 43 CFR 19.6 - Regulations respecting administration and uses of wilderness areas under jurisdiction of the...

    Science.gov (United States)

    2010-10-01

    ... which may be designated as wilderness areas by statute shall be developed with a view to protecting such... manner as will leave them unimpaired for future use and enjoyment as wilderness, with inconsistent uses...

  16. 76 FR 78933 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2011-12-20

    ..., electronic record requirements, and investigator initiated research. Topics for discussion include the...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Clinical Research Associates (SoCRA), is announcing a public workshop. The public workshop on FDA's...

  17. Oral Administration of N-Acetyl-D Glucosamine Polymer Particles Down-Regulates Airway Allergic Responses

    National Research Council Canada - National Science Library

    Shibata, Yoshimi

    2006-01-01

    ... (IL-12, IL-18 and TNFo) that down-regulate allergic immune responses. We also found that administration of chitin particles resulted in less likely induce the production of IL-10 and prostaglandin E2 (PGE2...

  18. 77 FR 15370 - General Services Administration Acquisition Regulation; Information Collection; Price Reductions...

    Science.gov (United States)

    2012-03-15

    ... Services Administration Acquisition Regulation; Information Collection; Price Reductions Clause; Extension... notice of request for comments regarding OMB Control No. 3090-0235, Price Reductions Clause, published in... 16, 2012. ADDRESSES: Submit comments identified by Information Collection 3090- 0235, Price...

  19. 77 FR 6985 - General Services Administration Acquisition Regulation; Reinstatement of Coverage Pertaining to...

    Science.gov (United States)

    2012-02-10

    ... Acquisition Regulation; Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building... Administration Acquisition Regulation (GSAR) to restore guidance on the release of claims after completion of construction and building service contracts to ensure contractors are paid in accordance with their contract...

  20. 75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-03

    ..., et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition and... Regulation Supplement; Business Systems--Definition and Administration (DFARS Case 2009-D038) AGENCY: Defense.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  1. Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration.

    Science.gov (United States)

    Feng, Ru; Zhao, Zhen-Xiong; Ma, Shu-Rong; Guo, Fang; Wang, Yan; Jiang, Jian-Dong

    2018-01-01

    Berberine (BBR) is considered a multi-target drug that has significant advantages. In contrast to its significant pharmacological effects in clinic, the plasma level of BBR is very low. Our previous work revealed that dihydroberberine (dhBBR) could be an absorbable form of BBR in the intestine, and butyrate is an active metabolite that is generated by gut bacteria in rats. In this study, for the first time we describe gut microbiota-regulated pharmacokinetics in beagle dogs after oral administration of BBR by single (50 mg/kg) or multiple doses (50 mg/kg/d) for 7 days. GC-MS, GC, LC-MS/MS, and LC/MS n -IT-TOF were used to detect dhBBR, butyrate and BBR as well as its Phase I and II metabolites, respectively. The results showed that dhBBR was not detected in dog plasma but was excreted in small amounts in the feces of dogs examined on days 3 and 7. Butyrate was generated by gut bacteria and increased by 1.3- and 1.2-fold in plasma or feces, respectively, after 7 days of BBR treatment compared to the levels before treatment. Changes of intestinal bacterial composition were analyzed by 16S rRNA genes analysis. The results presented that dogs treated with BBR for 7 days increased both the abundance of the butyrate- and the nitroreductases- producing bacteria. We also identified chemical structures of the Phase I and II metabolites and analyzed their contents in beagle dogs. Eleven metabolites were detected in plasma and feces after BBR oral administration (50 mg/kg) to dogs, including 8 metabolites of Phase I and III metabolites of Phase II. The pharmacokinetic profile indicated that the concentration of BBR in plasma was low, with a C max value of 36.88 ± 23.45 ng/mL. The relative content of glucuronic acid conjugates (M11) was higher than those of other metabolites (M1, M2, M12, and M14) in plasma. BBR was detected in feces, with high excreted amounts on day 3 (2625.04 ± 1726.94 μg/g) and day 7 (2793.43 ± 488.10 μg/g). In summary, this is the first study to

  2. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    Science.gov (United States)

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  3. Administration

    DEFF Research Database (Denmark)

    Bogen handler om den praksis, vi kalder administration. Vi er i den offentlige sektor i Danmark hos kontorfolkene med deres sagsmapper, computere, telefoner,, lovsamlinger,, retningslinier og regneark. I bogen udfoldes en mangfoldighed af konkrete historier om det administrative arbejde fra...... forskellige områder i den offentlige sektor. Hensigten er at forstå den praksis og faglighed der knytter sig til det administrative arbejde...

  4. Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications

    OpenAIRE

    Shen, Liang; Liu, Lu; Ji, Hong-Fang

    2017-01-01

    ABSTRACT Curcumin, the major active component of turmeric (Curcuma longa), is widely used as a spice and food-coloring agent, and also exhibits multiple biological activities. However, as curcumin has poor systemic bioavailability its pharmacology remains to be elucidated. Owing to the high concentration of curcumin in the gastrointestinal tract after oral administration, we hypothesize that it may exert regulative effects on the gut microbiota. We investigated the regulative effects of oral ...

  5. A study in improvement of administrative system in the nuclear safety regulation

    International Nuclear Information System (INIS)

    Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho

    2001-03-01

    One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents

  6. A study in improvement of administrative system in the nuclear safety regulation

    Energy Technology Data Exchange (ETDEWEB)

    Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho [Chungnam National Univ., Taejon (Korea, Republic of)

    2001-03-15

    One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents.

  7. 77 FR 37523 - Proposed Revisions to the Export Administration Regulations: Implementation of Export Control...

    Science.gov (United States)

    2012-06-21

    ...), respectively, that would implement various aspects of what has become known as the Export Control Reform... spirit and substance. BIS issued a notice soliciting public comment on streamlining its regulations...

  8. 78 FR 27239 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2013-05-09

    ... Services Administration Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales... Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial funding fee and sales reporting. A notice was published in the...

  9. 75 FR 13129 - General Services Administration Acquisition Regulation; Submission for OMB Review; Sales Practice...

    Science.gov (United States)

    2010-03-18

    ... Services Administration Acquisition Regulation; Submission for OMB Review; Sales Practice Format--Supplies and/or Services With an Established Catalog Price and Sales Practices Format-- Supplies and/or... will be submitting to the Office of Management and Budget (OMB) a request to review and approve a new...

  10. 75 FR 14448 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2010-03-25

    ... requirements, and investigator initiated research. Topics for discussion include the following: (1) What FDA...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Society of Clinical Research Associates, Inc. (SoCRA) is announcing a public workshop entitled ``FDA...

  11. 77 FR 8886 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2012-02-15

    ..., electronic record requirements, and investigator initiated research. Topics for discussion include the...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Research Associates (SoCRA) is announcing a public workshop. The public workshop on FDA's clinical trial...

  12. 76 FR 51040 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2011-08-17

    ... requirements, and investigator initiated research. Topics for discussion include the following: (1) What FDA...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Clinical Research Associates (SoCRA) is announcing a public workshop. The public workshop on FDA's clinical...

  13. Administrative procedures for regulating construction and operation of nuclear power plants

    International Nuclear Information System (INIS)

    Cochaud, J.P.

    1981-01-01

    This article first explains that nuclear power plants in France are governed by a complex system of regulations within the framework of different laws concerning, in particular, protection of the environment, public health and workers. It then examines the administrative procedures and the licensing regime for nuclear power plants. (NEA) [fr

  14. 77 FR 58380 - General Services Administration Acquisition Regulation; Submission for OMB Review; Price...

    Science.gov (United States)

    2012-09-20

    ...] General Services Administration Acquisition Regulation; Submission for OMB Review; Price Reductions Clause... requirement regarding the GSAR Price Reductions Clause. A notice was published in the Federal Register at 76... identified by Information Collection 3090- 0235, Price Reduction Clause, by any of the following methods...

  15. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-09

    ..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...

  16. 78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

    Science.gov (United States)

    2013-12-19

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 730, 732, 734, 736, 738, 740... Administration Regulations AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final rule. SUMMARY: This... INFORMATION CONTACT: William Arvin, Regulatory Policy Division, Bureau of Industry and Security, Telephone...

  17. 75 FR 28632 - Federal Housing Administration (FHA)-Temporary Exemption From Compliance With FHA's Regulation on...

    Science.gov (United States)

    2010-05-21

    ... Housing Administration (FHA)--Temporary Exemption From Compliance With FHA's Regulation on Property... by the seller and the seller does not come under any of the exemptions to this 90-day period that are... objective of increasing the availability of affordable homes for first- time and other purchasers and...

  18. Risk regulation and deliberation in EU administrative governance: GMO regulation and its reform

    NARCIS (Netherlands)

    Weimer, M.

    2015-01-01

    The article analyses the problems of EU risk regulation of genetically modified organisms (GMOs) through the lens of deliberative theories of EU law and governance, such as deliberative supranationalism and experimentalist governance. Previous research had suggested that the GMO issue is not

  19. Prohibited or regulated? LSD psychotherapy and the United States Food and Drug Administration.

    Science.gov (United States)

    Oram, Matthew

    2016-09-01

    Over the 1950s and early 1960s, the use of the hallucinogenic drug lysergic acid diethylamide (LSD) to facilitate psychotherapy was a promising field of psychiatric research in the USA. However, during the 1960s, research began to decline, before coming to a complete halt in the mid-1970s. This has commonly been explained through the increase in prohibitive federal regulations during the 1960s that aimed to curb the growing recreational use of the drug. However, closely examining the Food and Drug Administration's regulation of LSD research in the 1960s will reveal that not only was LSD research never prohibited, but that the administration supported research to a greater degree than has been recognized. Instead, the decline in research reflected more complex changes in the regulation of pharmaceutical research and development. © The Author(s) 2016.

  20. The Medicines (Administration of Radioactive Substances) Regulations 1978 (S.I. no.1006)

    International Nuclear Information System (INIS)

    1978-01-01

    These regulations prohibit the administration of radioactive medicinal products except by doctors or dentists holding a certificate issued by the Health Ministers for such purpose. They also lay down the procedure for the grant of such certificates and provide for the appointment of a Committee to advise the authorities on these matters. The Regulations were made in pursuance of Council Directive 76/579/Euratom which lays down the revised standards for the health protection of the general public and workers against the dangers of ionizing radiation. (NEA) [fr

  1. Outline of safety regulations and administrations for commercial nuclear power plants in Japan

    International Nuclear Information System (INIS)

    Kinichi Yamamoto

    1987-01-01

    Outline of safety regulations and administrations for the commercial nuclear power plants in Japan is briefly described. The strict measures for safety assurance are always taken based on the principle of defense-indepth. In the actual procedures of regulatory control, the examinations and inspections shall be performed at each individual step in the stage of applications, and also in the stage of constructions. Thus, those regulatory examinations and inspections shall be performed in detail and carefully, and at the most suitable time; resulting in an effective regulatory control by the Ministry of International Trade and Industry. (author)

  2. 78 FR 61873 - Revisions to the Export Administration Regulations (EAR) To Make the Commerce Control List (CCL...

    Science.gov (United States)

    2013-10-04

    ... entitled Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War; Submersible...'' references by this rule will require exporters to spend substantially more time to determine the scope of the...

  3. Evaluation of the Navy Implementation of DOD Financial Management Regulation, Volume 14, Administrative Control of Funds and Antideficiency Act Violations

    National Research Council Canada - National Science Library

    Lane, F

    1996-01-01

    On August 1, 1995, the Under Secretary of Defense (Comptroller) released for implementation Financial Management Regulation, volume 14, "Administrative Control of Funds and Antideficiency Act Violations," August 1, 1995...

  4. Understanding the administrative regulation on occupational health and trend in China.

    Science.gov (United States)

    Zhou, Zhijun

    2018-03-27

    With the immense economic growth and social development, China has gained worldwide attention. With the quick growth of industrialization, several international professionals are gaining interest in occupational management system and in the role of the Chinese Government in protecting the worker's health. The Law on Prevention and Control of Occupational Diseases and the Work Safety Law are the two most important laws in China, which highlight the responsibilities of the employer, employee, governmental agencies, authorized occupational health service agency, and other stakeholders. The State Council comprises two departments, namely, the State Administration on Work Safety (SAWS) and the National Health and Family Planning Commission (NHFPC), which are responsible for governing the occupational health work. A series of regulations and standards have been promulgated by the Chinese Government to encourage or instruct the employers to fulfill their responsibility; however, several issues persist related to occupational health work, including administrative, technological, and sociocultural aspects. At present, the Chinese Government wants to enhance the reform in both economic and administrative structures, and the adjustments for modifying and/or improving the occupational health regulatory system are expected. Notably, the occupational health work in China must be altered for better.

  5. Radiation Protection Ordinance 1989. Supplement with Radiation Protection Register Ordinance, general administration regulation pursuant to Sect. 45 Radiation Protection Ordinance, general administration regulation pursuant to Sect. 62 sub-sect. radiation passport

    International Nuclear Information System (INIS)

    Veith, H.M.

    1990-01-01

    The addendum contains regulations issued supplementary to the Radiation Protection Ordinance: The Radiation Protection Register as of April 3, 1990 including the law on the setting up of a Federal Office on Radiation Protection; the general administration regulation pursuant to Sect. 45 Radiation Protection Ordinance as of February 21, 1990; the general administration regulation pursuant to Sect. 62 sub-sect. 2 Radiation Protection Ordinance as of May 3, 1990 (AVV Radiation passport). The volume contains, apart from the legal texts, the appropriate decision by the Bundesrat, the official explanation from the Bundestag Publications as well as a comprehensive introduction into the new legal matter. (orig.) [de

  6. Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.

    Directory of Open Access Journals (Sweden)

    Hyung Jin Choi

    Full Text Available Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21 days. Rats were divided into control, ghrelin ad libitum-fed (ghrelin ad lib-fed, and ghrelin pair-fed groups. Ghrelin intracerebroventricular infusion significantly increased body weight in ghrelin ad lib-fed rats but not in ghrelin pair-fed rats, as compared with control rats. Chronic intracerebroventricular ghrelin infusion significantly increased bone mass in the ghrelin pair-fed group compared with control as indicated by increased bone volume percentage, trabecular thickness, trabecular number and volumetric bone mineral density in tibia trabecular bone. There was no significant difference in trabecular bone mass between the control group and the ghrelin ad-lib fed group. Chronic intracerebroventricular ghrelin infusion significantly increased the mineral apposition rate in the ghrelin pair-fed group as compared with control. In conclusion, chronic central administration of ghrelin increases bone mass through a mechanism that is independent of body weight, suggesting that ghrelin may have a bone anabolic effect through the central nervous system.

  7. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Science.gov (United States)

    2012-11-19

    ...; Information Collection; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD), General... collection requirement concerning cost accounting standards administration. Public comments are particularly... Information Collection 9000- 0129, Cost Accounting Standards Administration by any of the following methods...

  8. Administrative-legal regulation of causes and conditions determining corruption in social sphere

    Directory of Open Access Journals (Sweden)

    Aleksandr V. Polukarov

    2017-12-01

    Full Text Available Objective to show the capabilities of administrativelegal regulation for combating the causes and conditions determining corrupt behavior in the social sphere. Methods dialectic approach to cognition of social phenomena enabling to analyze them in historical development and functioning in the context of the totality of objective and subjective factors that determined the choice of the following research methods analysis synthesis comparison systematic formallegal comparativelegal methods. Results the reasons and conditions determining the corruption in the social sphere were disclosed this leads to the conclusion that corruption counteraction should be based on 1 recognition of the social sphere as the key object of protection against corruption 2 elaboration of special administrativelegal means of corruption counteraction in the social sphere. It is necessary to take into account the features of social relations in such sectors as education healthcare culture physical culture and sports etc. A number of foreign countries took the path of developing legislation on corruption counteraction taking into account the specifics of various social sphere segments functioning. This experience is quite interesting from the viewpoint of developing means of combating the causes and conditions that determine corruption in the social sphere. A number of the Russian Federation subjects also elaborate regional programs of combating corruption in education healthcare and culture. In our opinion this experience should be transferred to the federal level of legal regulation. This will help to create a fullfledged system of corruption counteraction in the social sphere taking into account different levels of its functioning. Scientific novelty for the first time in administrativelegal science the ldquolaw of torts aspect of corruption in the social sphererdquo issue is considered the work reveals the causes and conditions that determine corruption in the social

  9. The NKG2D ligands RAE-1δ and RAE-1ε differ with respect to their receptor affinity, expression profiles and transcriptional regulation.

    Science.gov (United States)

    Cédile, Oriane; Popa, Natalia; Pollet-Villard, Frédéric; Garmy, Nicolas; Ibrahim, El Chérif; Boucraut, José

    2010-10-19

    RAE-1 is a ligand of the activating receptor NKG2D expressed by NK cells, NKT, γδT and some CD8(+)T lymphocytes. RAE-1 is overexpressed in tumor cell lines and its expression is induced after viral infection and genotoxic stress. We have recently demonstrated that RAE-1 is expressed in the adult subventricular zone (SVZ) from C57BL/6 mice. RAE-1 is also expressed in vitro by neural stem/progenitor cells (NSPCs) and plays a non-immune role in cell proliferation. The C57BL/6 mouse genome contains two rae-1 genes, rae-1δ and rae-1ε encoding two different proteins. The goals of this study are first to characterize the in vivo and in vitro expression of each gene and secondly to elucidate the mechanisms underlying their respective expression, which are far from known. We observed that Rae-1δ and Rae-1ε transcripts are differentially expressed according to tissues, pathological conditions and cell lines. Embryonic tissue and the adult SVZ mainly expressed Rae-1δ transcripts. The NSPCs derived from the SVZ also mainly expressed RAE-1δ. The interest of this result is especially related to the observation that RAE-1δ is a weak NKG2D ligand compared to RAE-1ε. On the contrary, cell lines expressed either similar levels of RAE-1δ and RAE-1ε proteins or only RAE-1ε. Since the protein expression correlated with the level of transcripts for each rae-1 gene, we postulated that transcriptional regulation is one of the main processes explaining the difference between RAE-1δ and RAE-1ε expression. We indeed identified two different promoter regions for each gene: one mainly involved in the control of rae-1δ gene expression and the other in the control of rae-1ε expression. RAE-1δ and RAE-1ε differ with respect to their function and the control of their expression. Immune function would be mainly exerted by RAE-1ε and non-immune function by RAE-1δ.

  10. The influence of teacher perceived administration of self-regulated learning on students' motivation and information-processing

    NARCIS (Netherlands)

    Rozendaal, JS; Minnaert, A; Boekaerts, M

    This study investigates the influence of teacher perceived administration of self-regulated learning on students' motivation and information-processing over time. This was done in the context of the Interactive Learning group System (ILS (R)): a large-scale innovation program in Dutch vocational

  11. Regulation and Device Development: Tips for Optimizing Your Experience With the Food and Drug Administration.

    Science.gov (United States)

    Brooks, Steven S

    2017-06-01

    Physician-inventors are in a unique position to identify unserved patient needs, and innovate solutions to clinical problems. These solutions may also have associated commercial opportunities. The logistics of developing these medical products, however, can seem a daunting task. One of the primary barriers in the United States is the regulatory process of the Food and Drug Administration (FDA). In this article, we will explore the risk-based approach used by the FDA which forms a framework to consider the regulatory pathway and the process to gain regulatory clearance or approval for medical devices. Inherent device properties and the procedural risk of the devices will determine the rigor with which they are scrutinized by FDA, and the evidentiary requirements to legally market them. Data and evidentiary development will vary depending on risk and regulatory precedent and may or may not require clinical data This regulatory paradigm will determine into which risk-based device class they fit, and whether they are regulated under the 510(k) or premarket approval application pathways. The FDA, although gatekeeper of the US market and tasked with determining which products are safe and effective, can be a powerful ally for product development. They have significant scientific and medical expertise, and mechanisms to both provide guidance, and also to consider novel approaches to product development and evidence development. Early interaction for routine and novel products alike can result in expedited and efficient development. This collaborative approach can be best practice to most expeditiously develop the next generation of products, getting them into the hands of US doctors and into the treatment of US patients. Copyright © 2017. Published by Elsevier Inc.

  12. 77 FR 14016 - General Services Administration Acquisition Regulation; Preparation, Submission, and Negotiation...

    Science.gov (United States)

    2012-03-08

    ..., Submission, and Negotiation of Subcontracting Plans; Correction AGENCY: General Services Administration (GSA..., Preparation, Submission, and Negotiation of Subcontracting Plans; Correction. Correction In the information...

  13. 77 FR 56766 - Updated Statements of Legal Authority for the Export Administration Regulations

    Science.gov (United States)

    2012-09-14

    ... necessary, to select regulatory approaches that maximize net benefits (including potential economic.... 15 CFR Part 756 Administrative practice and procedure, Exports, Penalties. 15 CFR Part 760 Boycotts...

  14. 76 FR 58393 - Updated Statements of Legal Authority for the Export Administration Regulations

    Science.gov (United States)

    2011-09-21

    ... benefits (including potential economic, environmental, public health and safety effects, distributive... Boycotts, Exports, Reporting and recordkeeping requirements. 15 CFR Part 762 Administrative practice and...

  15. Relevance in print of law of administrative regulations according to paragraph 48 BImSchG in the licensing procedure

    International Nuclear Information System (INIS)

    Breuer, R.

    1978-01-01

    The author discusses in great detail the legal problem of administrative regulations according to paragraph 48 of the Bundes-Immissionsschutzgesetz, BImSchG (Federal Act for the prevention of immissions) and their relevance in point of law in licensing procedures. He very carefully and skilfully presents the different opinions stated in the precedents and by the body of doctrine and quite convincingly explains why he rejects the doctrine of allowing the administration some latitude in their judgement, and thus the doctrine of the defensible opinion with regard to the examination by the court of undefined legal terms. According to the auther's view, the administrative regulations should be regarded as anticipated expert opinions because of the way they are drawn up and because of the way the relevant committees setting up the rules are constituted, i.e. they can serve as a basis for judical decisions. In this connection the author points out that in any case it is left to the court's decisions whether a non-formal expert opinion is deemed to be sufficient, or whether the rules of procedure require a formal expert opinion. Furthermore, several ways of enhancing the binding effect of the administrative regulations pursuant to paragraph 48 of the BImSchG by means of legislatory measures are shown. (UN) [de

  16. 77 FR 72917 - Editorial Corrections to the Commerce Control List of the Export Administration Regulations

    Science.gov (United States)

    2012-12-07

    ...-01] RIN 0694-AF62 Editorial Corrections to the Commerce Control List of the Export Administration... corrects reference and typographical errors in the Commerce Control List (CCL) in the Export Administration... seven categories of the Commerce Control List (CCL) to correct spelling and typographical errors and...

  17. 77 FR 28390 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 527...

    Science.gov (United States)

    2012-05-14

    .... Purpose The General Services Administration will be requesting the Office of Management and Budget to... GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-0007; Docket 2011-0016; Sequence 12] General... Qualifications and Financial Information AGENCY: Office of the Chief Finance Officer, GSA. ACTION: Notice of...

  18. 77 FR 5020 - General Services Administration Acquisition Regulation; Information Collection; GSA Form 527...

    Science.gov (United States)

    2012-02-01

    ... INFORMATION: A. Purpose The General Services Administration will be requesting the Office of Management and... GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-0007; Docket 2011-0001; Sequence 12] General... Qualifications and Financial Information AGENCY: Office of the Chief Finance Officer, GSA. ACTION: Notice of...

  19. Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal.

    Science.gov (United States)

    Kim, Ronald; Sepulveda-Orengo, Marian T; Healey, Kati L; Williams, Emily A; Reissner, Kathryn J

    2018-01-01

    Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of withdrawal, with longer access to cocaine and longer withdrawal periods leading to greater decreases in GLT-1 protein. However, the mechanism(s) by which cocaine downregulates GLT-1 protein remains unknown. We used qRT-PCR to examine gene expression of GLT-1 splice isoforms (GLT-1A, GLT-1B) in the NAc, prelimbic cortex (PL) and basolateral amygdala (BLA) of rats, following two widely used models of cocaine self-administration: short-access (ShA) self-administration, and the long-access (LgA) self-administration/incubation model. While downregulation of GLT-1 protein is observed following ShA cocaine self-administration and extinction, this model did not lead to a change in GLT-1A or GLT-1B gene expression in any brain region examined. Forced abstinence following ShA cocaine self-administration also was without effect. In contrast, LgA cocaine self-administration and prolonged abstinence significantly decreased GLT-1A gene expression in the NAc and BLA, and significantly decreased GLT-1B gene expression in the PL. No change was observed in NAc GLT-1A gene expression one day after LgA cocaine self-administration, indicating withdrawal-induced decreases in GLT-1A mRNA. In addition, LgA cocaine self-administration and withdrawal induced hypermethylation of the GLT-1 gene in the NAc. These results indicate that a decrease in NAc GLT-1 mRNA is only observed after extended access to cocaine combined with protracted abstinence, and that epigenetic mechanisms likely contribute to this effect. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. μ Opioid Receptor Expression after Morphine Administration Is Regulated by miR-212/132 Cluster.

    Directory of Open Access Journals (Sweden)

    Adrian Garcia-Concejo

    Full Text Available Since their discovery, miRNAs have emerged as a promising therapeutical approach in the treatment of several diseases, as demonstrated by miR-212 and its relation to addiction. Here we prove that the miR-212/132 cluster can be regulated by morphine, through the activation of mu opioid receptor (Oprm1. The molecular pathways triggered after morphine administration also induce changes in the levels of expression of oprm1. In addition, miR-212/132 cluster is actively repressing the expression of mu opioid receptor by targeting a sequence in the 3' UTR of its mRNA. These findings suggest that this cluster is closely related to opioid signaling, and function as a post-transcriptional regulator, modulating morphine response in a dose dependent manner. The regulation of miR-212/132 cluster expression is mediated by MAP kinase pathway, CaMKII-CaMKIV and PKA, through the phosphorylation of CREB. Moreover, the regulation of both oprm1 and of the cluster promoter is mediated by MeCP2, acting as a transcriptional repressor on methylated DNA after prolonged morphine administration. This mechanism explains the molecular signaling triggered by morphine as well as the regulation of the expression of the mu opioid receptor mediated by morphine and the implication of miR-212/132 in these processes.

  1. 77 FR 22191 - Revisions to the Export Administration Regulations (EAR): Export Control Classification Number...

    Science.gov (United States)

    2012-04-13

    ..., Director, Office of National Security and Technology Transfer Controls, by phone at (202) 482-0092 or by... Administrative practice and procedure, Exports, Inventions and patents, Research science and technology. 15 CFR...

  2. 77 FR 59613 - General Services Administration Acquisition Regulation (GSAR) Part 523; Submission for OMB Review...

    Science.gov (United States)

    2012-09-28

    ... items of hazardous material allows for appropriate handling of such items throughout GSA's supply chain... 3090- 0205 by any of the following methods: Regulations.gov : http://www.regulations.gov . Submit... customers. Non-Collection and/or a less frequently conducted collection of the information resulting from...

  3. 77 FR 36543 - General Services Administration Acquisition Regulation (GSAR) Part 523; Information Collection...

    Science.gov (United States)

    2012-06-19

    ... handling of such items throughout GSA's supply chain system. The information is used in GSA warehouses, stored in an NSN database and provided to GSA customers. Non-Collection and/or a less frequently... any of the following methods: Regulations.gov : http://www.regulations.gov . Submit comments via the...

  4. Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man.

    Science.gov (United States)

    Hallschmid, Manfred; Benedict, Christian; Born, Jan; Fehm, Horst-Lorenz; Kern, Werner

    2004-10-30

    Maintaining a stable body weight set-point is assumed to rely on a homeostatic central nervous system (CNS) regulation of body fat with the particular involvement of hypothalamic pathways. The peripheral adiposity signals insulin and leptin convey information on the amount of energy stored as body fat to the arcuate nucleus of the hypothalamus, where anabolic/orexigenic and catabolic/anorexigenic pathways interact to regulate food intake and energy expenditure. One of the most prominent orexigenic messengers is neuropeptide Y (NPY), whereas melanocortins, including alpha-melanocyte-stimulating hormone (alpha-MSH), are essential for inducing anorexigenic effects. The melanocortin receptor 4 (MC4-R) plays the most important role in mediating catabolic effects of alpha-MSH. In this review, we present a series of own studies on NPY, insulin and MSH/ACTH4-10, an MC4-R agonist. The studies were all based on the intranasal route of administration which enables a direct access of the peptides to hypothalamic functions. NPY acutely attenuated electrocortical signs of meal-related satiety. Prolonged intranasal administration of insulin as well as of MSH induced weight loss in healthy human subjects. However, overweight subjects did not lose body fat after MSH administration. The results corroborate in humans the significance of all three messengers for the central nervous regulation of adiposity and might contribute to the future development of medical strategies against body-weight-related disorders.

  5. [Vocational Health Schools (ETSUS) in Brazil: regulation of the integration of teaching-service-administrative sustainability of ETSUS].

    Science.gov (United States)

    Borges, Fabiano Tonaco; Garbin, Cléa Adas Saliba; Siqueira, Carlos Eduardo; Garbin, Artênio José Ísper; Rocha, Najara Barbosa da; Lolli, Luíz Fernando; Moimaz, Suzely Adas Saliba

    2012-04-01

    The scope of this study was to discuss the administrative sustainability of Brazil's Vocational Health Schools (ETSUS) based on the principle of teaching and service integration, which brings a new dimension to healthcare work as yet unregulated by Brazilian public administration. It was a qualitative study using case study methodology. The research involved a semi-structured questionnaire given to ETSUS managers addressing institutional, administrative, and work management aspects. The sample was composed of 6 ETSUS that belong to the Network of Vocational Health Schools (RET-SUS). The ETSUS showed centralized planning and management, and decentralized implementation of their core activities. The majority did not have administrative autonomy and relied heavily on funding from the federal government. According to ETSUS managers, the lack of regulation of teaching activities by civil servants weakens the management of ETSUS. The ETSUS have managerial problems related to teaching-service integration, which has to be regulated in order to guarantee the sustainability of these schools and avoid conflicts with Brazilian legislation.

  6. Case Law: - Canada: Criminal Court decision respecting attempted export of nuclear-related dual use items to Iran: Her Majesty the Queen vs Yadegari (2010); - Czech Republic: Supreme Administrative Court on the legal status of CEZ (2010)

    International Nuclear Information System (INIS)

    Anon.

    2010-01-01

    Case law 1: Canada - Criminal Court decision respecting attempted export of nuclear-related dual use items to Iran: Her Majesty the Queen vs Yadegari (2010). This case concerns a recent, successful prosecution that was undertaken before the Ontario Court of Justice relating to violations of export control legislation in Canada, nuclear regulatory legislation, customs law, criminal law, as well as Canadian law implementing UN Security Council resolutions concerning Iran. The convictions that have been registered in this case, notwithstanding the fact that the decision is currently under appeal,2 demonstrate the importance of a functioning export control regime and effective counter-proliferation strategy. The case represents the first conviction for a regulatory offense under the Nuclear Safety and Control Act,3 in force since 2000, and Mr. Yadegari is the first Canadian to be convicted under the United Nations Act, Canada's legislation by which it implements UN resolutions. Case law 2: Czech Republic - Supreme Administrative Court on the legal status of CEZ (2010). The Supreme Administrative Court in its decision of 6 October 20098 ruled on whether CEZ, a.s., which is the operator of nuclear installations at the Temelin and Dukovany sites in the Czech Republic, is governed by the Act on Free Access to Information. The court stated that the rules laid down in the Act on Free Access to Information, also apply to CEZ which is considered as a 'public institution'. The following reasons led the court to this interpretation: first, CEZ was established by decision of the state in the course of the privatisation process. Secondly, the company is effectively controlled by the state, which is still its majority owner and the profits of the company also compose a portion of state budget revenues. Finally, there is a public interest served in the function of the company

  7. The effective dose and pattern of soybean extract administration to regulate body weight of laboratory rats

    Directory of Open Access Journals (Sweden)

    Meilinah Hidayat

    2016-07-01

    the intake of protein and suppress appetite for short-term. Detam 1 variety is a high-quality soybean according to the Minister of Agriculture of Indonesia. Soybean protein extract Detam 1 by Deak method contains high levels of β conglycinin. The purpose of this study was to determine the effective dose of protein extract Detam 1 soybean Deak Method (PEDSDM in reducing food intake, regulate body weight, and plasma CCK level for 14 and 28 days at various dosage and pattern of treatment on male Wistar rats. Methods: There were eleven groups of treatment (n = 3, administrated with extracts at 5 mg/1x/day, 10 mg/1x/day, 20 mg/1x/day, 2.5 mg/2x/day, 5 mg/2x/day, 10 mg/2x/day and 1.7mg/3x/day, 3.4mg/3x/day, 6.7 mg/3x/day, negative control group (distilled water and positive control group (Sibutramine. Food intake (g, weight loss (g and measurement of plasma Cholecystokinin levels by ELISA (ng /ml Results: The results showed that the highest percentage decrease in food intake is: group 3.4mg /3x/ day (p <0.05, inhibition weight gain for 14 days: group 10 mg /1x/ day, for 28 days: group 1.7 mg/3x/day (p <0.05, increased plasma Cholecystokinin levels: group 20 mg /1x/day (p <0.05. Conclusions: The effective dose and pattern administrating the rats for 14 days is extract of 10 mg once a day in the morning, for 28 days is 1.7 mg three times a day. (Health Science Journal of Indonesia 2016;7:17-26 Keywords: Soybean var Detam 1 -effective dose - body weight - Cholecystokinin 

  8. Local ordinances as an instrument of social exclusion: the regulation affecting the homeless is administrative law of the enemy

    Directory of Open Access Journals (Sweden)

    Eduardo Melero Alonso

    2017-03-01

    Full Text Available This paper discusses local ordinances, especially the so-called coexistence ordinances, to the extent they affect the daily activities of the homeless. There are three areas of regulation: the prohibition of begging; a ban on sleeping, washing and perform physiological needs in public spaces; and the prohibition of sorting through garbage. This regulation is subjected to a critical analysis, focusing on the fact that has an impact on the fundamental rights of the homeless. The basic parameters of control are the reserve of law and, above all, the principle of proportionality. The conclusion reached is that, in many cases, this regulation is not only illegal, it can also be included within the category Administrative Law of the enemy.

  9. 78 FR 40891 - Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War...

    Science.gov (United States)

    2013-07-08

    ... Vehicles; Vessels of War; Submersible Vessels, Oceanographic Equipment; Related Items; and Auxiliary and... Regulations: Military Vehicles; Vessels of War; Submersible Vessels, Oceanographic Equipment; Related Items... military vehicles and related items; vessels of war and related items; submersible vessels, oceanographic...

  10. 76 FR 34886 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

    Science.gov (United States)

    2011-06-15

    ... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... information technology (IT) supplies, services and systems with security requirements. DATES: Effective Date... effective date that include information technology (IT) supplies, services and systems with security...

  11. 77 FR 749 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

    Science.gov (United States)

    2012-01-06

    ... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... orders that include information technology (IT) supplies, services and systems. DATES: Effective Date... 6, 2012 that include information technology (IT) supplies, services and systems with security...

  12. 75 FR 4565 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2010-01-28

    ... Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales Reporting AGENCY... Management and Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial [[Page 4566

  13. 76 FR 17138 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2011-03-28

    ... initiated research. Topics for discussion include the following: (1) What FDA Expects in a Pharmaceutical Clinical Trial; (2) Adverse Event Reporting--Science, Regulation, Error, and Safety; (3) Part 11 Compliance...

  14. 75 FR 51824 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2010-08-23

    ... discussion include the following: (1) What FDA expects in a pharmaceutical clinical trial; (2) adverse event reporting--science, regulation, error, and safety; (3) Part 11 Compliance--Electronic signatures; (4...

  15. The Food and Drug Administration and Drug Legalization: A Brief Model of Regulation

    OpenAIRE

    Kalam, Murad

    2002-01-01

    This paper offers a brief model of FDA regulation of currently illegal narcotics in the United States. Given that nearly three out of four Americans believe that the drug war has failed, recent calls from prominent liberal and conservative thinkers to legalize drugs, and state “compassionate use†ballot initiatives, future drug legalization is at least conceivable in the United States. Yet, how would the FDA regulate NLD’s under its current st...

  16. Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1.

    Science.gov (United States)

    Prince, Courtney D; Rau, Andrew R; Yorgason, Jordan T; España, Rodrigo A

    2015-01-21

    Extensive evidence suggests that the hypocretins/orexins influence cocaine reinforcement and dopamine signaling via actions at hypocretin receptor 1. By comparison, the involvement of hypocretin receptor 2 in reward and reinforcement processes has received relatively little attention. Thus, although there is some evidence that hypocretin receptor 2 regulates intake of some drugs of abuse, it is currently unclear to what extent hypocretin receptor 2 participates in the regulation of dopamine signaling or cocaine self-administration, particularly under high effort conditions. To address this, we examined the effects of hypocretin receptor 1, and/or hypocretin receptor 2 blockade on dopamine signaling and cocaine reinforcement. We used in vivo fast scan cyclic voltammetry to test the effects of hypocretin antagonists on dopamine signaling in the nucleus accumbens core and a progressive ratio schedule to examine the effects of these antagonists on cocaine self-administration. Results demonstrate that blockade of either hypocretin receptor 1 or both hypocretin receptor 1 and 2 significantly reduces the effects of cocaine on dopamine signaling and decreases the motivation to take cocaine. In contrast, blockade of hypocretin receptor 2 alone had no significant effects on dopamine signaling or self-administration. These findings suggest a differential involvement of the two hypocretin receptors, with hypocretin receptor 1 appearing to be more involved than hypocretin receptor 2 in the regulation of dopamine signaling and cocaine self-administration. When considered with the existing literature, these data support the hypothesis that hypocretins exert a permissive influence on dopamine signaling and motivated behavior via preferential actions on hypocretin receptor 1.

  17. 78 FR 57156 - General Services Administration Acquisition Regulation; Submission for OMB Review; Modifications...

    Science.gov (United States)

    2013-09-17

    ... GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-0302; Docket No. 2013-0001; Sequence 9... (GSAR) to add clause 552.243-81 Modifications (Federal Supply Schedule) and an Alternate I version of..., Modifications (Federal Supply Schedule). The alternate version of the clause implements and mandates electronic...

  18. 78 FR 60695 - Regulatory Reorganization; Administrative Changes to Regulations Due to the Consolidation of the...

    Science.gov (United States)

    2013-10-02

    ... Consolidation of the Financial Management Service and the Bureau of the Public Debt Into the Bureau of the... Service''). The new bureau consolidated the bureaus formerly known as the Financial Management Service... Register on May 24, 2013. This consolidation requires reorganization of, and administrative changes to...

  19. 77 FR 59790 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...

    Science.gov (United States)

    2012-10-01

    ... and Forms. This final rule is part of the General Services Administration Acquisition Manual (GSAM... the prescription for inclusion of the clause at 552.204-9, Personal Identity Verification Requirements... the ``National Industrial Security Program Operating Manual (NISPOM)'', and link to the web address...

  20. Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration

    OpenAIRE

    Self, David W.; Choi, Kwang-Ho; Simmons, Diana; Walker, John R.; Smagula, Cynthia S.

    2004-01-01

    Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine system, and the role of this modulation in addictive behavior in rats. Extinction training normalizes tyrosine hydro...

  1. Regulation of operant oral ethanol self-administration: a dose-response curve study in rats.

    Science.gov (United States)

    Carnicella, Sebastien; Yowell, Quinn V; Ron, Dorit

    2011-01-01

    Oral ethanol self-administration procedures in rats are useful preclinical tools for the evaluation of potential new pharmacotherapies as well as for the investigation into the etiology of alcohol abuse disorders and addiction. Determination of the effects of a potential treatment on a full ethanol dose-response curve should be essential to predict its clinical efficacy. Unfortunately, this approach has not been fully explored because of the aversive taste reaction to moderate to high doses of ethanol, which may interfere with consumption. In this study, we set out to determine whether a meaningful dose-response curve for oral ethanol self-administration can be obtained in rats. Long-Evans rats were trained to self-administer a 20% ethanol solution in an operant procedure following a history of excessive voluntary ethanol intake. After stabilization of ethanol self-administration, the concentration of the solution was varied from 2.5 to 60% (v/v), and operant and drinking behaviors, as well as blood ethanol concentration (BEC), were evaluated following the self-administration of a 20, 40, and 60% ethanol solution. Varying the concentration of ethanol from 2.5 to 60% after the development of excessive ethanol consumption led to a typical inverted U-shaped dose-response curve. Importantly, rats adapted their level and pattern of responding to changes in ethanol concentration to obtain a constant level of intake and BEC, suggesting that their operant behavior is mainly driven by the motivation to obtain a specific pharmacological effect of ethanol. This procedure can be a useful and straightforward tool for the evaluation of the effects of new potential pharmacotherapies for the treatment of alcohol abuse disorders. Copyright © 2010 by the Research Society on Alcoholism.

  2. 77 FR 73289 - Hazardous Substances and Articles; Administration and Enforcement Regulations: Revisions to...

    Science.gov (United States)

    2012-12-10

    ... of Animals, and the Physicians Committee for Responsible Medicine. 1. Non-animal Testing Alternatives... Hazardous Substances Act (FHSA). DATES: This rule is effective on January 9, 2013. FOR FURTHER INFORMATION... proposed amendments to the regulations that interpret, supplement, or provide alternatives to definitions...

  3. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2010-01-20

    ... extension of a previously approved information collection requirement concerning cost accounting standards... include pertinent rules and regulations related to the Cost Accounting Standards along with necessary... impact estimates and descriptions in cost accounting practices and also to provide information on CAS...

  4. Legal and administrative problems in regulating public participation in licensing of nuclear installations

    International Nuclear Information System (INIS)

    Cornelis, J.C.

    1981-10-01

    This general analysis of the question of public acceptance of nuclear activities focuses on the problems met by all governmental authorities in implementing their nuclear programmes. The author highlights the need for more specific regulations aimed at guaranteeing fuller information of the public and ensuring closer participation by it. (NEA) [fr

  5. The Hidden Cost of Regulation: The Administrative Cost of Reporting Serious Reportable Events.

    Science.gov (United States)

    Blanchfield, Bonnie B; Acharya, Bijay; Mort, Elizabeth

    2018-04-01

    More than half of the 50 states (27) and the District of Columbia require reporting of Serous Reportable Events (SREs). The goal is to hold providers accountable and improve patient safety, but there is little information about the administrative cost of this reporting requirement. This study was conducted to identify costs associated with investigating and reporting SREs. This qualitative study used case study methods that included interviewing staff and review of data and documents to investigate each SRE occurring at one academic medical center during fiscal year 2013. A framework of tasks and a model to categorize costs was created. Time was summarized and costs were estimated for each SRE. The administrative cost to process 44 SREs was estimated at $353,291, an average cost of $8,029 per SRE, ranging $6,653 for an environmental-related SRE to $21,276 for a device-related SRE. Care management SREs occurred most frequently, costing an average $7,201 per SRE. Surgical SREs, the most expensive on average, cost $9,123 per SRE. Investigation of events accounted for 64.5% of total cost; public reporting, 17.2%; internal reporting, 10.2%; finance and administration, 6.0%; and 2.1%, other. Even with 26 states mandating reporting, the 17.2% incremental cost of public reporting is substantial. Policy makers should consider the opportunity costs of these resources, averaging $8,029 per SRE, when mandating reporting. The benefits of public reporting should be collectively reviewed to ensure that the incremental costs in this resource-constrained environment continue to improve patient safety and that trade-offs are acknowledged. Copyright © 2017 The Joint Commission. Published by Elsevier Inc. All rights reserved.

  6. Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.

    Science.gov (United States)

    Cho, Jin Hee; Cho, Yun Ha; Kim, Hyo Young; Cha, Seung Ha; Ryu, Hyun; Jang, Wooyoung; Shin, Kyung Ho

    2015-04-01

    Caffeine produces a variety of behavioral effects including increased alertness, reduced food intake, anxiogenic effects, and dependence upon repeated exposure. Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine. Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum. However, it is not clear whether acute caffeine administration alters CART in other areas of the brain. To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice. We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas. In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg. This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. The Regulated Third Sector: Administrative Practices Of Citizenship And Constitutional Efficiency Applied

    Directory of Open Access Journals (Sweden)

    Mateus Moura de Oliveira

    2016-12-01

    Full Text Available Beginning from an approach about the evolution of organizational models of the States, this work goals, initially, outline the evolution of these models in the Brazilian State, analyzing the development of the Third Sector as an exponent of the Managing State. Establish afterwards the development of the entities of civil society and the urge for its regulation due to dissemination of its many species. After short report of the most recent regulatory practices, the importance of the Sector concludes itself as apex of the active role of citizenship, whereas advocate the constitutional efficiency in the atuation of such entities.

  8. Oral Administration of N-Acetyl-D-Glucosamine Polymer Particles Down-Regulates Airway Allergic Responses

    Science.gov (United States)

    2007-03-01

    deoxygalactose and galactose, respectively. Relatively less mITLN-1 was eluted by these monosaccharides . The oligomeric Hu/Mo chimeric ITLN-1 had...Abeygunawardana, C., Bush, C. A. and Cisar, J. O. (1991) Complete structure of the cell surface polysaccharide of Streptococcus oralis C104: a 600-MHz NMR...Hoogerhout, P. and van Boom, J. H. (1988) (1-5)-linked beta-D-galactofuranosides are immunodominant in extracellular polysaccharides of

  9. Respect changes your life!

    CERN Document Server

    Alizée Dauvergne

    2010-01-01

    CERN has recently joined the Geneva-based association "Le respect, ça change la vie" (Respect can change our lives). As its name suggests, the association promotes respect, in all its forms. This decision will enable CERN to share some of its values, those it has in common with the association, with the community at large.   The new bilingual logo of the "Le respect ça change la vie" association. "CERN has been a member of the Geneva-based association "Le respect, ça change la vie" since March," says Friedemann Eder, Head of the Relations with the Host States Service. Mutual respect, respecting the differences and the work of others, respect on the road, in the family, at school, etc. The association, which was founded in 2003 and now has a large number of members, promotes this universal value and encourages discussion on it. "CERN's history shows the importance and success o...

  10. Respect in Education

    Science.gov (United States)

    Giesinger, Johannes

    2012-01-01

    This article discusses the educational significance of the moral demand for respect. In "Ethics and Education," Richard Peters presents a conception of educational respect that was recently taken up by Krassimir Stojanov. This article responds to both Peters' and Stojanov's contributions and proposes another understanding of educational respect:…

  11. Respecting the Grapevine.

    Science.gov (United States)

    Carroll, David J.

    2001-01-01

    Administrators can create word-of-mouth communication that dispels negative attitudes and build good school reputations by discovering what parents and students are saying, targeting employee satisfaction and retention, providing excellent customer service, actively seeking and handling complaints, nurturing champions, and integrating "grapevine"…

  12. Predicted Impact of the Food and Drug Administration's Menu-Labeling Regulations on Restaurants in 4 New Jersey Cities.

    Science.gov (United States)

    Gruner, Jessie; DeWeese, Robin S; Lorts, Cori; Yedidia, Michael J; Ohri-Vachaspati, Punam

    2018-02-01

    To determine the proportion of restaurants that will be required to post calorie information under the Food and Drug Administration's menu-labeling regulations in 4 New Jersey cities. We classified geocoded 2014 data on 1753 restaurant outlets in accordance with the Food and Drug Administration's guidelines, which will require restaurants with 20 or more locations nationwide to post calorie information. We used multivariate logistic regression analyses to assess the association between menu-labeling requirements and census tract characteristics. Only 17.6% of restaurants will be affected by menu labeling; restaurants in higher-income tracts have higher odds than do restaurants in lower-income tracts (odds ratio [OR] = 1.55; P = .02). Restaurants in non-Hispanic Black (OR = 1.62; P = .02) and mixed race/ethnicity (OR = 1.44; P = .05) tracts have higher odds than do restaurants in non-Hispanic White tracts of being affected. Additional strategies are needed to help consumers make healthy choices at restaurants not affected by the menu-labeling law. These findings have implications for designing implementation strategies for the law and for evaluating its impact.

  13. Respect for rational autonomy.

    Science.gov (United States)

    Walker, Rebecca L

    2009-12-01

    The standard notion of autonomy in medical ethics does not require that autonomous choices not be irrational. The paper gives three examples of seemingly irrational patient choices and discusses how a rational autonomy analysis differs from the standard view. It then considers whether a switch to the rational autonomy view would lead to overriding more patient decisions but concludes that this should not be the case. Rather, a determination of whether individual patient decisions are autonomous is much less relevant than usually considered in determining whether health care providers must abide by these decisions. Furthermore, respect for rational autonomy entails strong positive requirements of respect for the autonomy of the person as a rational decision maker. The rationality view of autonomy is conceptually stronger than the standard view, allows for a more nuanced understanding of the practical moral calculus involved in respecting patient autonomy, and promotes positive respect for patient autonomy.

  14. Toleration out of respect?

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2013-01-01

    Under conditions of pluralism different cultures, interests or values can come into conflict, which raises the problem of how to secure peaceful co-existence. The idea of toleration historically emerged as an answer to this problem. Recently Rainer Forst has argued that toleration should not just...... be based on a modus vivendi designed to secure peaceful co-existence, but should be based on moral reasons. Forst therefore advances what he calls the ‘respect conception’ of toleration as an in itself morally desirable type of relationship, which is furthermore the only conception of toleration...... that avoids various so-called ‘paradoxes of toleration’. The paper first examines whether Forst’s respect conception can be applied descriptively to distinguish between actual patterns of behaviour and classify different acts of toleration. Then the focus is shifted to toleration out of respect as a normative...

  15. Ombud's Corner: Respect @ CERN

    CERN Multimedia

    Sudeshna Datta-Cockerill

    2014-01-01

    Since 2010 CERN has been a member of the Geneva-based association "Le respect, ça change la vie". Four years later and in conjunction with CERN’s celebration of its 60 years of ‘science for peace’, it is time to launch a new respectful workplace awareness campaign under the auspices of the Ombud.   Mutual respect is a basic pillar of peace. At CERN, we pride ourselves on our history, which started when a handful of Europe’s visionary scientists saw the opportunity that an international laboratory for fundamental research would present in bringing nations together. That idea has worked very well and, today, our success can be measured not only in terms of unprecedented scientific achievements but also in terms of training and education, and exemplary collaboration across borders, cultures and an extensive range of differences. In order for history to continue along these positive lines, and coming back to the awareness campai...

  16. Respect as an Incentive

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Villeval, Marie-Claire

    Assuming that people care not only about what others do but also on what others think, we study respect as a non-monetary source of motivation in a context where the length of the employment relationship is endogenous.  In our three-stage gift-exchange experiment, the employer can express respect...... by giving the employee costly symbolic rewards after observing his level of effort. This experiment sheds light on the extent to which symbolic rewards are used, how they affect employees' further effort, the duration of relationships, and the profits of employers. Furthermore, we study whether employers...

  17. Respect or resignation?

    DEFF Research Database (Denmark)

    Liveng, Anne

    2005-01-01

    Students in the social- and health care worker education must learn to show "understanding" and "respect" for the seniors they help. How difficult it is to go from theory to practise becomes painfully obvious the forst time a student empties a bed pan.......Students in the social- and health care worker education must learn to show "understanding" and "respect" for the seniors they help. How difficult it is to go from theory to practise becomes painfully obvious the forst time a student empties a bed pan....

  18. Toleration out of respect?

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2014-01-01

    be based on a modus vivendi designed to secure peaceful co-existence, but should be based on moral reasons. Forst therefore advances what he calls the ‘respect conception’ of toleration as an in itself morally desirable type of relationship, which is furthermore the only conception of toleration...

  19. Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques

    Science.gov (United States)

    Siciliano, Cody A.; Calipari, Erin S.; Yorgason, Jordan T.; Lovinger, David M.; Mateo, Yolanda; Jimenez, Vanessa A.; Helms, Christa M.; Grant, Kathleen A.; Jones, Sara R.

    2016-01-01

    Rationale Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use, and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergic deficiencies are unknown. Objective Here we examined the specific dopaminergic adaptations that produce hypodopaminergia and contribute to alcohol use disorders using direct, sub-second measurements of dopamine signaling in nonhuman primates following chronic ethanol self-administration. Methods Female rhesus macaques completed one year of daily (22 hr/day) ethanol self-administration. Subsequently, fast-scan cyclic voltammetry was used in nucleus accumbens core brain slices to determine alterations in dopamine terminal function, including release and uptake kinetics, and sensitivity to quinpirole (D2/D3 dopamine receptor agonist) and U50,488 (kappa-opioid receptor agonist) induced inhibition of dopamine release. Results Ethanol drinking greatly increased uptake rates, which were positively correlated with lifetime ethanol intake. Furthermore, the sensitivity of dopamine D2/D3 autoreceptors and kappa-opioid receptors, which both act as negative regulators of presynaptic dopamine release, were moderately and robustly enhanced in ethanol drinkers. Conclusions Greater uptake rates and sensitivity to D2-type autoreceptor and kappa-opioid receptor agonists could converge to drive a hypodopaminergic state, characterized by reduced basal dopamine and an inability to mount appropriate dopaminergic responses to salient stimuli. Together, we outline the specific alterations to dopamine signaling that may drive ethanol-induced hypofunction of the dopamine system, and suggest that the dopamine and dynorphin/kappa-opioid receptor systems may be efficacious pharmcotherapeutic targets in the treatment of alcohol use disorders. PMID:26892380

  20. Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques.

    Science.gov (United States)

    Siciliano, Cody A; Calipari, Erin S; Yorgason, Jordan T; Lovinger, David M; Mateo, Yolanda; Jimenez, Vanessa A; Helms, Christa M; Grant, Kathleen A; Jones, Sara R

    2016-04-01

    Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergic deficiencies are not fully understood. Here we examined the specific dopaminergic adaptations that produce hypodopaminergia and contribute to alcohol use disorders using direct, sub-second measurements of dopamine signaling in nonhuman primates following chronic ethanol self-administration. Female rhesus macaques completed 1 year of daily (22 h/day) ethanol self-administration. Subsequently, fast-scan cyclic voltammetry was used in nucleus accumbens core brain slices to determine alterations in dopamine terminal function, including release and uptake kinetics, and sensitivity to quinpirole (D2/D3 dopamine receptor agonist) and U50,488 (kappa opioid receptor agonist) induced inhibition of dopamine release. Ethanol drinking greatly increased uptake rates, which were positively correlated with lifetime ethanol intake. Furthermore, the sensitivity of dopamine D2/D3 autoreceptors and kappa opioid receptors, which both act as negative regulators of presynaptic dopamine release, was moderately and robustly enhanced in ethanol drinkers. Greater uptake rates and sensitivity to D2-type autoreceptor and kappa opioid receptor agonists could converge to drive a hypodopaminergic state, characterized by reduced basal dopamine and an inability to mount appropriate dopaminergic responses to salient stimuli. Together, we outline the specific alterations to dopamine signaling that may drive ethanol-induced hypofunction of the dopamine system and suggest that the dopamine and dynorphin/kappa opioid receptor systems may be efficacious pharmacotherapeutic targets in the treatment of alcohol use disorders.

  1. Adaxial/abaxial specification in the regulation of photosynthesis and stomatal opening with respect to light orientation and growth with CO2 enrichment in the C4 species Paspalum dilatatum.

    Science.gov (United States)

    Soares, Ana Sofia; Driscoll, Simon P; Olmos, Enrique; Harbinson, Jeremy; Arrabaça, Maria Celeste; Foyer, Christine H

    2008-01-01

    Whole-plant morphology, leaf structure and composition were studied together with the effects of light orientation on the dorso-ventral regulation of photosynthesis and stomatal conductance in Paspalum dilatatum cv. Raki plants grown for 6 wk at either 350 or 700 microl l(-1) CO(2). Plant biomass was doubled as a result of growth at high CO(2) and the shoot:root ratio was decreased. Stomatal density was increased in the leaves of the high CO(2)-grown plants, which had greater numbers of smaller stomata and more epidermal cells on the abaxial surface. An asymmetric surface-specific regulation of photosynthesis and stomatal conductance was observed with respect to light orientation. This was not caused by dorso-ventral variations in leaf structure, the distribution of phosphoenolpyruvate carboxylase (PEPC) and ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) proteins or light absorptance, transmittance or reflectance. Adaxial/abaxial specification in the regulation of photosynthesis results from differential sensitivity of stomatal opening to light orientation and fixed gradients of enzyme activation across the leaf.

  2. Gene transcripts selectively down-regulated in the shell of the nucleus accumbens long after heroin self-administration are up-regulated in the core independent of response contingency.

    Science.gov (United States)

    Jacobs, Edwin H; de Vries, Taco J; Smit, August B; Schoffelmeer, Anton N M

    2004-01-01

    Long-term drug-induced alterations in neurotransmission within the nucleus accumbens (NAc) shell and core may underlie relapse to drug-seeking behavior and drug-taking upon re-exposure to drugs and drug-associated stimuli (cues) during abstinence. Using an open screening strategy, we recently identified 25 gene transcripts, encoding for proteins involved in neuronal functioning and structure that are down-regulated in rat NAc shell after contingent (active), but not after non-contingent (passive), heroin administration. Studying the expression of the same transcripts in the NAc core by means of quantitative PCR, we now demonstrate that most of these transcripts are up-regulated in that NAc subregion long (3 weeks) after heroin self-administration in rats. A similar up-regulation in gene expression was also apparent in the NAc core of animals with a history of non-contingent heroin administration (yoked controls). These data indicate that heroin self-administration differentially regulates genes in the NAc core as compared with the shell. Moreover, whereas cognitive processes involved in active drug self-administration (e.g., instrumental learning) seems to direct gene expression in the NAc shell, neuroplasticity in the NAc core may be due to the pharmacological effects of heroin (including Pavlovian conditioning), as expressed in rats upon contingent as well as non-contingent administration of heroin.

  3. Respect as an Incentive

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Villeval, Marie-Claire

    whether employers’ decisions to give symbolic rewards are driven by strategic considerations. We find that employers do make use of symbolic rewards and chiefly to express their satisfaction with the employee. Symbolic rewards are associated with higher profits and increased probability of continuing......In this paper we examine respect as a non-monetary source of motivation. Our experiment sheds light on the extent to which symbolic rewards are used, how they are valued by the employees, and how they affect employee effort, the duration of relationships, and profits of employers. We also study...

  4. Energy Building Regulations: The Effect of the Federal Performance Standards on Building Code Administration and the Conservation of Energy in New Buildings.

    Science.gov (United States)

    Kopper, William D.

    1980-01-01

    Explores the changes in the administration and enforcement of building regulations that will be engendered by the proposed federal energy building standards. Also evaluates the effectiveness of those standards in meeting congressional intent. Available from U.C. Davis Law Review, School of Law, Martin Luther King Jr. Hall, University of…

  5. Muscarinic receptor plasticity in the brain of senescent rats: down-regulation after repeated administration of diisopropyl fluorophosphate

    International Nuclear Information System (INIS)

    Pintor, A.; Fortuna, S.; Volpe, M.T.; Michalek, H.

    1988-01-01

    Potential age-related differences in the response of Fischer 344 rats to subchronic treatment with diisopropylfluorophosphate (DFP) were evaluated in terms of brain cholinesterase (ChE) inhibition and muscarinic receptor sites. Male 3- and 24-month old rats were sc injected with sublethal doses of DFP for 2 weeks and killed 48 hrs after the last treatment. In the cerebral cortex, hippocampus and striatum of control rats a significant age-related reduction of ChE and of maximum number of 3 H-QNB binding sites (Bmax) was observed. The administration of DFP to senescent rats resulted in more pronounced and longer lasting syndrome of cholinergic stimulation, with marked body weight loss and 60% mortality. The percentage inhibition of brain ChE induced by DFP did not differ between young and senescent rats. As expected, in young rats DFP caused a significant decrease of Bmax, which in the cerebral cortex reached about 40%. In the surviving senescent rats, the percentage decrease of Bmax due to DFP with respect to age-matched controls was very similar to that of young animals, especially in the cerebral cortex. Thus there is great variability in the response of aged rats to DFP treatment, from total failure of adaptive mechanisms resulting in death to considerable muscarinic receptor plasticity

  6. Muscarinic receptor plasticity in the brain of senescent rats: down-regulation after repeated administration of diisopropyl fluorophosphate

    Energy Technology Data Exchange (ETDEWEB)

    Pintor, A.; Fortuna, S.; Volpe, M.T.; Michalek, H.

    1988-01-01

    Potential age-related differences in the response of Fischer 344 rats to subchronic treatment with diisopropylfluorophosphate (DFP) were evaluated in terms of brain cholinesterase (ChE) inhibition and muscarinic receptor sites. Male 3- and 24-month old rats were sc injected with sublethal doses of DFP for 2 weeks and killed 48 hrs after the last treatment. In the cerebral cortex, hippocampus and striatum of control rats a significant age-related reduction of ChE and of maximum number of /sup 3/H-QNB binding sites (Bmax) was observed. The administration of DFP to senescent rats resulted in more pronounced and longer lasting syndrome of cholinergic stimulation, with marked body weight loss and 60% mortality. The percentage inhibition of brain ChE induced by DFP did not differ between young and senescent rats. As expected, in young rats DFP caused a significant decrease of Bmax, which in the cerebral cortex reached about 40%. In the surviving senescent rats, the percentage decrease of Bmax due to DFP with respect to age-matched controls was very similar to that of young animals, especially in the cerebral cortex. Thus there is great variability in the response of aged rats to DFP treatment, from total failure of adaptive mechanisms resulting in death to considerable muscarinic receptor plasticity.

  7. Combating global warming. Possible rules, regulations and administrative arrangements for a global market in CO2 emission entitlements

    International Nuclear Information System (INIS)

    1994-12-01

    When in 1991 the UNCTAD secretariat launched its research into the idea of controlling carbon dioxide emissions through a system of 'tradeable permits', there was little support for this approach. Some felt that the idea was premature and should not detract from efforts to introduce more conventional measures, such as environmental taxes and new regulations. However, in a few short years, the idea of using tradeable market-based instruments to combat global warming has gained widespread acceptance. The UNCTAD secretariat's 1992 study on a global system of tradeable carbon emission entitlements (UNCTAD/RDP/DFP/1), was widely regarded as a major breakthrough in this area. This study argued that tradeable permits were both an efficient means of controlling man-made carbon dioxide emissions at minimum cost, and an effective mechanism for transferring resources to developing countries and countries in transition, to help them to contribute to the international effort to abate emissions of greenhouse gases. The study contained a detailed assessment of key technical elements of a tradeable CO 2 entitlements system, including permit allocation techniques, resource transfers, equity/distributional implications, institutional and administrative requirements. The present publication explores the institutional requirements for both policy-making and the organization of a global market in CO 2 emission allowances. It shows that one can start with a simple pilot scheme based on the joint implementation of commitments, which constitutes the cornerstone of the Framework Convention, and evolve gradually to a more complete system on the basis of 'learning by doing'. Since the use of markets can dramatically lower the cost of controlling greenhouse gas emissions, it is clearly in the self-interest of major emitters to act as 'market leaders' willing to pioneer

  8. Differential regulation of proopiomelanocortin (POMC mRNA expression in hypothalamus and anterior pituitary following repeated cyanamide with ethanol administration

    Directory of Open Access Journals (Sweden)

    Kinoshita Hiroshi

    2005-01-01

    Full Text Available Background/Aim. We have investigated proopiomelanocortin (POMC mRNA expression in the arcuate nucleus of the hypothalamus (ARC and the anterior lobe of the pituitary (AL following repeated cyanamide-ethanol reaction (CER. Methods. Adult male Sprague -Dawley rats (250 −290 gr were housed in a temperature and humidity controlled environment with free access to food and water. Four experimental groups were used as follows: saline (as control, cyanamide alone, ethanol alone and ethanol with cyanamide. The animals received daily intraperitoneal injections (i.p. of cyanamide (10mg/kg, 60 min before ethanol dosing with or without ethanol (1g/kg for 5 consecutive days, and were sacrificed 60 min after the last dosing of ethanol. The results were presented as the mean ± SEM for each group. All groups within each data set were compared by one-way ANOVA followed by Fisher PLSD test for multiple comparisons. A value of p<0.05 was considered significant. Results. The POMC mRNA levels in ARC were significantly decreased with cyanamide compared to the control and ethanol alone (p<0.05 and p<0.05 respectively, but increased in AL following repeated CER. Conclusion. We speculate that this differential regulation of POMC mRNA expression may be partially involved in the preventive effects on alcohol intake in response to CER.

  9. Regulation

    International Nuclear Information System (INIS)

    Ballereau, P.

    1999-01-01

    The different regulations relative to nuclear energy since the first of January 1999 are given here. Two points deserve to be noticed: the decree of the third august 1999 authorizing the national Agency for the radioactive waste management to install and exploit on the commune of Bures (Meuse) an underground laboratory destined to study the deep geological formations where could be stored the radioactive waste. The second point is about the uranium residues and the waste notion. The judgment of the administrative tribunal of Limoges ( 9. july 1998) forbidding the exploitation of a storage installation of depleted uranium considered as final waste and qualifying it as an industrial waste storage facility has been annulled bu the Court of Appeal. It stipulated that, according to the law number 75663 of the 15. july 1965, no criteria below can be applied to depleted uranium: production residue (possibility of an ulterior enrichment), abandonment of a personal property or simple intention to do it ( future use aimed in the authorization request made in the Prefecture). This judgment has devoted the primacy of the waste notion on this one of final waste. (N.C.)

  10. Equipment for the conditioning of core components in the fuel element storage pool with particular respect to the design required by the conditions for nuclear facilities in operation and the surveillance in accordance with atomic rules and regulations

    International Nuclear Information System (INIS)

    Dumpe, J.; Schwiertz, V.; Geiser, C.; Prucker, E.

    2001-01-01

    In nuclear power plants worn out and activated parts from the reactor core (core components) which are placed into the fuel element storage pool arise on a regular basis during the technical maintenance and the review. The disposal of these core components due to radiation protection aspects is only feasible within the fuel element storage pool during the operation of the NPP using techniques of the under water conditioning. Therefore, special GNS equipment is used for the conditioning, using under water conditioning equipment, such as UWS, BZ, and ZVA, a number of lifting and auxiliary equipment for mounting and dismantling purposes and the handling of the core components and the waste casks within the fuel element storage pool. These components must meet particular safety requirements with regard to their integrity and reliability. They are designed according to the requirements on nuclear components (KTA). The manipulating equipment must be partly redundant and the protection goals for nuclear accidents must be met. The Bavarian Ministry for Development and Environment tasked the TUeV Sueddeutschland with the surveillance and control. The conditioning equipment of GNS is therefore designed in co-ordination with the examiner of the Governmental Regulating Agency, in particular respect to all safety aspects. Furthermore the examiners perform reviews of the construction and the documentation during the design and construction phase. (orig.)

  11. Inhibitory effects of ginseng total saponin on up-regulation of cAMP pathway induced by repeated administration of morphine.

    Science.gov (United States)

    Seo, Jeong-Ju; Lee, Jae-Woong; Lee, Wan-Kyu; Hong, Jin-Tae; Lee, Chong-Kil; Lee, Myung-Koo; Oh, Ki-Wan

    2008-02-01

    We have reported that ginseng total saponin (GTS) inhibited the development of physical and psychological dependence on morphine. However, the possible molecular mechanisms of GTS are unclear. Therefore, this study was undertaken to understand the possible molecular mechanism of GTS on the inhibitory effects of morphine-induced dependence. It has been reported that the up-regulated cAMP pathway in the LC of the mouse brain after repeated administration of morphine contributes to the feature of withdrawals. GTS inhibited up-regulation of cAMP pathway in the LC after repeated administration of morphine in this experiment. GTS inhibited cAMP levels and protein expression of protein kinase A (PKA). In addition, GTS inhibited the increase of cAMP response element binding protein (CREB) phosphorylation. Therefore, we conclude that the inhibitory effects of GTS on morphine-induced dependence might be mediated by the inhibition of cAMP pathway.

  12. Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats

    International Nuclear Information System (INIS)

    Pintor, A.; Fortuna, S.; De Angelis, S.; Michalek, H.

    1990-01-01

    Potential age-related differences in the recovery rate of brain cholinesterase activity (ChE) and muscarinic acetylcholine receptor binding sites (mAChRs) following reduction induced by repeated treatment with diisopropyl fluorophosphate (DFP) were evaluated in Sprague-Dawley rats. Male 3- and 24-month old rats were s.c. injected with DFP on alternate days for 2 weeks and killed 48 hr and 7, 14, 21, 28 and 35 days after the last treatment. In the hippocampus and striatum, but not in the cerebral cortex, of control rats there as a significant age-related decline of ChE activity and maximal density of 3H-QNB binding sites (Bmax). The repeated administration of DFP during the first week caused a syndrome of cholinergic stimulation both in aged and young rats. The syndrome was more pronounced, in terms of intensity and duration in aged than in young animals resulting in 40 and 12% mortality, respectively; during the second week the syndrome attenuated in the two age-groups. The percentage inhibition of brain ChE at the end of DFP treatment did not differ between young and surviving aged rats. The down-regulation of mACRs was present in the three brain regions of both young and age rats (from 20 to 40%). Factorial analysis of variance showed significant differences for age, recovery rate, and significant interaction between age and recovery rate, both for ChE and mAChRs in young rats the three brain areas

  13. Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats

    Energy Technology Data Exchange (ETDEWEB)

    Pintor, A.; Fortuna, S.; De Angelis, S.; Michalek, H. (Istituto Superiore di Sanita, Rome (Italy))

    1990-01-01

    Potential age-related differences in the recovery rate of brain cholinesterase activity (ChE) and muscarinic acetylcholine receptor binding sites (mAChRs) following reduction induced by repeated treatment with diisopropyl fluorophosphate (DFP) were evaluated in Sprague-Dawley rats. Male 3- and 24-month old rats were s.c. injected with DFP on alternate days for 2 weeks and killed 48 hr and 7, 14, 21, 28 and 35 days after the last treatment. In the hippocampus and striatum, but not in the cerebral cortex, of control rats there as a significant age-related decline of ChE activity and maximal density of 3H-QNB binding sites (Bmax). The repeated administration of DFP during the first week caused a syndrome of cholinergic stimulation both in aged and young rats. The syndrome was more pronounced, in terms of intensity and duration in aged than in young animals resulting in 40 and 12% mortality, respectively; during the second week the syndrome attenuated in the two age-groups. The percentage inhibition of brain ChE at the end of DFP treatment did not differ between young and surviving aged rats. The down-regulation of mACRs was present in the three brain regions of both young and age rats (from 20 to 40%). Factorial analysis of variance showed significant differences for age, recovery rate, and significant interaction between age and recovery rate, both for ChE and mAChRs in young rats the three brain areas.

  14. Intraventricular administration of Tenebrio molitor larvae extract regulates food intake and body weight in mice with high-fat diet-induced obesity.

    Science.gov (United States)

    Seo, Minchul; Kim, Jongwan; Moon, Seong-Su; Hwang, Jae-Sam; Kim, Mi-Ae

    2017-08-01

    We recently reported the in vitro and in vivo antiobesity effects of Tenebrio molitor larvae, a traditional food in many countries, but it remains unknown how the larvae affect appetite regulation in mice with diet-induced obesity. We hypothesized that the extract of T molitor larvae mediates appetite by regulating neuropeptide expression. We investigated T molitor larvae extract's (TME's) effects on anorexigenesis and endoplasmic reticulum (ER) stress-induced orexigenic neuropeptide expression in the hypothalami of obese mice. Intracerebroventricular TME administration suppressed feeding by down-regulating the expression of the orexigenic neuropeptides neuropeptide Y and agouti-related protein. T molitor larvae extract significantly reduced the expression of ER stress response genes. These results suggest that TME and its bioactive components are potential therapeutics for obesity and ER stress-driven disease states. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1

    OpenAIRE

    Prince, Courtney D.; Rau, Andrew R.; Yorgason, Jordan T.; Espa?a, Rodrigo A.

    2014-01-01

    Extensive evidence suggests that the hypocretins/orexins influence cocaine reinforcement and dopamine signaling via actions at hypocretin receptor 1. By comparison, the involvement of hypocretin receptor 2 in reward and reinforcement processes has received relatively little attention. Thus, although there is some evidence that hypocretin receptor 2 regulates intake of some drugs of abuse, it is currently unclear to what extent hypocretin receptor 2 participates in the regulation of dopamine s...

  16. Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice.

    Science.gov (United States)

    Olive, Michael Foster; Newton, Philip M

    2010-09-01

    Studies using targeted gene deletion in mice have revealed distinct roles for individual isozymes of the protein kinase C (PKC) family of enzymes in regulating sensitivity to various drugs of abuse. These changes in drug sensitivity are associated with altered patterns of drug self-administration. The purpose of this review is to summarize behavioral studies conducted on mice carrying targeted deletions of genes encoding specific PKC isozymes (namely the beta, gamma, delta, and epsilon isozymes), and to critically evaluate the possibility of using pharmacological inhibitors of specific PKC isozymes as modulators of the sensitivity to various drugs of abuse, as well as potential aids in the treatment of substance use disorders.

  17. Adaxial/abaxial specification in the regulation of photosynthesis and stomatal opening with respect to light orentation and growth with CO2 enrichment in the C4 species Paspalum dilatatum

    NARCIS (Netherlands)

    Soares, A.S.; Discoll, S.P.; Olmos, E.; Harbinson, J.; Arrabaca, M.C.

    2008-01-01

    Whole-plant morphology, leaf structure and composition were studied together with the effects of light orientation on the dorso-ventral regulation of photosynthesis and stomatal conductance in Paspalum dilatatum cv. Raki plants grown for 6 wk at either 350 or 700 µl l¿1 CO2. Plant biomass was

  18. Roles of Dietary Cobalt and Administration of Mixed Rumen Bacteria in Regulating Hematological Parameters of Pre-weaning Twin Lambs

    Directory of Open Access Journals (Sweden)

    T. Adelina

    2013-08-01

    Full Text Available Cobalt (Co is required by rumen microorganism for vitamin B12 synthesis. Vitamin B12 is an important cofactor for methionine synthesis and gluconeogenesis. In young ruminants up to 6–8 wk old, the rumen has not been completely developed and rumen microorganisms are not ready to supply vitamin B12. The aim of this research was to determine the potency of mixed rumen bacteria and dietary supplementation of Co and its effect on plasma glucose, blood minerals (Co, Fe, and Zn concentrations, and hematology of pre-weaning twin lambs. Twelve one month-old local twin lambs were assigned to 4 groups in a randomized complete block design. Lambs were fed cow milk at 10% body weight, adjusted weekly for 80 d. Mixed rumen bacteria were offered at 15 mL/d (8.295x1010 cfu. Dietary treatments were: 1 basal diet (Control, 2 basal diet + 1 mg/kg DM cyanocobalamin (VitB12 and 3 basal diet + 1 mg/kg DM of Co + administration of 15 mL mixed rumen bacteria (CoBac. There were no treatment effects on neither plasma glucose and blood mineral concentrations nor hematological profiles. This study demonstrated that pre-weaning twin lambs are not responsive to supplementation of Co and administration of mixed rumen bacteria.

  19. General administrative regulation relating to the Integrated Monitoring and Information System (IMIS) and its application in compliance with the Preventive Radiation Protection Act (StrlSchVG), (AVV-IMIS). As of 27 September 1995

    International Nuclear Information System (INIS)

    1995-01-01

    This general administrative regulation applies to the measuring, communication, compilation, processing, and documentation of data recorded within the IMIS system for the purpose of environmental radioactivity monitoring. (orig./HP) [de

  20. Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration.

    Science.gov (United States)

    Limmer, Franziska; Schinner, Elisabeth; Castrop, Hayo; Vitzthum, Helga; Hofmann, Franz; Schlossmann, Jens

    2015-10-01

    Sodium chloride reabsorption in the thick ascending limb of the loop of Henle is mediated by the Na(+)-K(+)-2Cl(-) cotransporter (NKCC2). The loop diuretic furosemide is a potent inhibitor of NKCC2. However, less is known about the mechanism regulating the electrolyte transporter. Considering the well-established effects of nitric oxide on NKCC2 activity, cGMP is likely involved in this regulation. cGMP-dependent protein kinase I (cGKI; PKGI) is a cGMP target protein that phosphorylates different substrates after activation through cGMP. We investigated the potential correlation between the cGMP/cGKI pathway and NKCC2 regulation. We treated wild-type (wt) and cGKIα-rescue mice with furosemide. cGKIα-rescue mice expressed cGKIα only under the control of the smooth muscle-specific transgelin (SM22) promoter in a cGKI deficient background. Furosemide treatment increased the urine excretion of sodium and chloride in cGKIα-rescue mice compared to that in wt mice. We analyzed the phosphorylation of NKCC2 by western blotting and immunostaining using the phosphospecific antibody R5. The administration of furosemide significantly increased the phosphorylated NKCC2 signal in wt but not in cGKIα-rescue mice. NKCC2 activation led to its phosphorylation and membrane translocation. To examine whether cGKI was involved in this process, we analyzed vasodilator-stimulated phosphoprotein, which is phosphorylated by cGKI. Furosemide injection resulted in increased vasodilator-stimulated phosphoprotein phosphorylation in wt mice. We hypothesize that furosemide administration activated cGKI, leading to NKCC2 phosphorylation and membrane translocation. This cGKI-mediated pathway could be a mechanism to compensate for the inhibitory effect of furosemide on NKCC2. © 2015 FEBS.

  1. Controlling prescription drug costs: regulation and the role of interest groups in Medicare and the Veterans Health Administration.

    Science.gov (United States)

    Frakt, Austin B; Pizer, Steven D; Hendricks, Ann M

    2008-12-01

    Medicare and the Veterans Health Administration (VA) both finance large outpatient prescription drug programs, though in very different ways. In the ongoing debate on how to control Medicare spending, some suggest that Medicare should negotiate directly with drug manufacturers, as the VA does. In this article we relate the role of interest groups to policy differences between Medicare and the VA and, in doing so, explain why such a large change to the Medicare drug program is unlikely. We argue that key policy differences are attributable to stable differences in interest group involvement. While this stability makes major changes in Medicare unlikely, it suggests the possibility of leveraging VA drug purchasing to achieve savings in Medicare. This could be done through a VA-administered drug-only benefit for Medicare-enrolled veterans. Such a partnership could incorporate key elements of both programs: capacity to accept large numbers of enrollees (like Medicare) and leverage to negotiate prescription drug prices (like the VA). Moreover, it could be implemented at no cost to the VA while achieving savings for Medicare and beneficiaries.

  2. The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration

    DEFF Research Database (Denmark)

    Licht, Cecilie Löe; Marcussen, Anders Bue; Wegener, Gregers

    2009-01-01

    The 5-hydroxytryptamine (5-HT(4)) receptor may be implicated in depression and is a new potential target for antidepressant treatment. We have investigated the brain 5-HT(4) receptor [(3)H]SB207145 binding in the Flinders Sensitive Line rat depression model by quantitative receptor autoradiography....... In the Flinders Sensitive Line, the 5-HT(4) receptor and 5-HT transporter binding were decreased in the dorsal and ventral hippocampus, and the changes in binding were directly correlated within the dorsal hippocampus. Chronic but not acute paroxetine administration caused a 16-47% down-regulation of 5-HT(4......) receptor binding in all regions evaluated including the basal ganglia and hippocampus, while 5-HT depletion increased the 5-HT(4) receptor binding in the dorsal hippocampus, hypothalamus, and lateral globus pallidus. In comparison, the 5-HT(2A) receptor binding was decreased in the frontal and cingulate...

  3. Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity.

    Science.gov (United States)

    Kim, Jongwan; Yun, Eun-Young; Quan, Fu-Shi; Park, Seung-Won; Goo, Tae-Won

    2017-01-01

    The α -glucosidase inhibitor, 1-deoxynojirimycin (DNJ), is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV) administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway to cause appetite suppression. We conclude that DNJ may reduce obesity by moderating feeding behavior and ER stress in the hypothalamic portion of the central nervous system (CNS).

  4. Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

    Directory of Open Access Journals (Sweden)

    Jongwan Kim

    2017-01-01

    Full Text Available The α-glucosidase inhibitor, 1-deoxynojirimycin (DNJ, is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2/signal transducers and activators of transcription 3 (STAT3 signaling pathway to cause appetite suppression. We conclude that DNJ may reduce obesity by moderating feeding behavior and ER stress in the hypothalamic portion of the central nervous system (CNS.

  5. Legal and administrative regulation of the petroleum industry in Trinidad and Tobago: a study of law and policy in petroleum development

    Energy Technology Data Exchange (ETDEWEB)

    Khan, K I.F.

    1984-01-01

    This work has, through an in-depth assessment of the law and institutions employed in the petroleum industry in Trinidad and Tobago, evaluated their viability in achieving declared state objectives and in providing a legal and administrative framework for regulating this industry. After considering the evolution of laws, policies, and institutions, the work focuses mainly on the petroleum contract, the national oil company, taxation of petroleum operations, and the ways of integrating the industry into the national economy and achieving an effective transfer of technology. These central areas are examined from a policy perspective which looks at their role, inter alia, as instruments of development, for securing active state participation, in the creation of an efficient and effective regulatory infrastructure and in allowing an optimum development of the resources, in the interest of the state. Further this examination provides the basis for suggested reforms and improvements to the existing model.

  6. Administrative contracts

    Directory of Open Access Journals (Sweden)

    Vukićević-Petković Milica

    2015-01-01

    Full Text Available Administrative contracts are a special type of contract where usually one of the contracting parties is a public law body and which is concluded for the performance of public service and the realization of a public interest. They go a long way since its inception to its eventual final acceptance of all the legal systems. One of the enduring characteristics of this type of contract is their disquised or unnoticed existence. This is why only monitoring their development may lead to a complete understanding of the importance and essence of this institution as well as the need for its complete legal regulation.

  7. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.

    Science.gov (United States)

    Kenny, Paul J; Chartoff, Elena; Roberto, Marisa; Carlezon, William A; Markou, Athina

    2009-01-01

    Nicotine is considered an important component of tobacco responsible for the smoking habit in humans. Nicotine increases glutamate-mediated transmission throughout brain reward circuitries. This action of nicotine could potentially contribute to its intrinsic rewarding and reward-enhancing properties, which motivate consumption of the drug. Here we show that the competitive N-methyl-D-aspartate (NMDA) receptor antagonist LY235959 (0.5-2.5 mg per kg) abolished nicotine-enhanced brain reward function, reflected in blockade of the lowering of intracranial self-stimulation (ICSS) thresholds usually observed after experimenter-administered (0.25 mg per kg) or intravenously self-administered (0.03 mg per kg per infusion) nicotine injections. The highest LY235959 dose (5 mg per kg) tested reversed the hedonic valence of nicotine from positive to negative, reflected in nicotine-induced elevations of ICSS thresholds. LY235959 doses that reversed nicotine-induced lowering of ICSS thresholds also markedly decreased nicotine self-administration without altering responding for food reinforcement, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor antagonist NBQX had no effects on nicotine intake. In addition, nicotine self-administration upregulated NMDA receptor subunit expression in the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA), suggesting important interactions between nicotine and the NMDA receptor. Furthermore, nicotine (1 microM) increased NMDA receptor-mediated excitatory postsynaptic currents in rat CeA slices, similar to its previously described effects in the VTA. Finally, infusion of LY235959 (0.1-10 ng per side) into the CeA or VTA decreased nicotine self-administration. Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug.

  8. Semantic Modeling of Administrative Procedures from a Spanish Regional Public Administration

    Directory of Open Access Journals (Sweden)

    Francisco José Hidalgo López

    2018-02-01

    Full Text Available Over the past few years, Public Administrations have been providing systems for procedures and files electronic processing to ensure compliance with regulations and provide public services to citizens. Although each administration provides similar services to their citizens, these systems usually differ from the internal information management point of view since they usually come from different products and manufacturers. The common framework that regulations demand, and that Public Administrations must respect when processing electronic files, provides a unique opportunity for the development of intelligent agents in the field of administrative processes. However, for this development to be truly effective and applicable to the public sector, it is necessary to have a common representation model for these administrative processes. Although a lot of work has already been done in the development of public information reuse initiatives and common vocabularies standardization, this has not been carried out at the processes level. In this paper, we propose a semantic representation model of both processes models and processes for Public Administrations: the procedures and administrative files. The goal is to improve public administration open data initiatives and help to develop their sustainability policies, such as improving decision-making procedures and administrative management sustainability. As a case study, we modelled public administrative processes and files in collaboration with a Regional Public Administration in Spain, the Principality of Asturias, which enabled access to its information systems, helping the evaluation of our approach.

  9. Teaching respect: a philosophical analysis

    Directory of Open Access Journals (Sweden)

    L. van Rooyen

    2000-03-01

    Full Text Available According to a Zulu proverb a human being can only become truly human because of others. Each person can only become more human, more himself- regardless of his sex - through the co-involvement of others. It is the love for one’s neighbour and the respect one has for him/her as a person which makes one consider the other party's feelings, viewpoints and circumstances. In order to arrive at a situation of peaceful coexistence it is important to realize that human attitudes and a mature life style evolve through a process of learning and interaction with others. It is a timeconsuming and costly process which starts at infancy and continues throughout someone's life. Instruction concerning interpersonal relations and the teaching of respect cannot be confined to individual lessons or working sessions at home or in school. Discussions and conversations concerning interpersonal relations need to form an integral and natural part of a child’s life within the home environment and throughout the pupil's school career. It is senseless if educators talk about the importance of teaching respect only to reveal disrespectful behaviour themselves, or to talk about the importance of self-esteem in the paying of respect whilst causing children to feel negative about themselves. To be able to express respect to other human beings, one needs to be respected. A child needs to experience how it feels when homage is paid. The following rule of life applies in this regard: one can never give if one has never received respect.

  10. Renewing the Respect for Similarity

    Directory of Open Access Journals (Sweden)

    Shimon eEdelman

    2012-07-01

    Full Text Available In psychology, the concept of similarity has traditionally evoked a mixture of respect, stemmingfrom its ubiquity and intuitive appeal, and concern, due to its dependence on the framing of the problemat hand and on its context. We argue for a renewed focus on similarity as an explanatory concept, bysurveying established results and new developments in the theory and methods of similarity-preservingassociative lookup and dimensionality reduction — critical components of many cognitive functions, aswell as of intelligent data management in computer vision. We focus in particular on the growing familyof algorithms that support associative memory by performing hashing that respects local similarity, andon the uses of similarity in representing structured objects and scenes. Insofar as these similarity-basedideas and methods are useful in cognitive modeling and in AI applications, they should be included inthe core conceptual toolkit of computational neuroscience.

  11. Respecting the right to strike

    CERN Multimedia

    Staff Association

    2015-01-01

    Since two years the representatives of the employers in the ILO, a tripartite multilateral body responsible for guaranteeing the correct application of an international labour code, try to weaken the global work regulations. On the occasion of the Global Day of Action for the right to strike at the invitation of the Geneva community of Union action (Communauté genevoise d’action syndicale) and the Swiss Trade Union Association (Union syndicale suisse) around noon on Wednesday 18th February some fifty staff representatives of international organizations gathered on the place des Nations in Geneva to reaffirm the importance of this fundamental right, too often flouted. A delegation of the CERN Staff Association was also present. In a short speech, the Staff Association said that, while being one of the fundamental human rights, to be efficient the right to strike must be used intelligently. It must be implemented taking into account the sensitivities of the professional environment and r...

  12. International science conference RESpect report

    Directory of Open Access Journals (Sweden)

    Radim Rybár

    2010-07-01

    Full Text Available Report is dedicated to aspects of conceiving the number of scientific magazine Acta Montanistica Slovaca, which purpose wasto publish specific key reports from the sixth year of international science conference RESpect 2011. The main aspect in the decisionprocess was to cover the conference agenda, complexity of the global problematic understanding, the subject of examination actualityand the results achievement level. The choice at the same time points on the technological, evaluative, environmental, economicaland application aspects of the RES usage, with accent on the Middle Europe region conditions.

  13. Enhanced down regulation of cortical ±-propranolol sensitive [3H]-DHA binding sites by co-administration of DMI and 5-HT1A partial agonist gepirone

    International Nuclear Information System (INIS)

    Geissler, M.A.; Yocca, F.D.

    1990-01-01

    The putative interrelationship between the noradrenergic and serotonergic systems has been supported by numerous studies. Recently, Dudley et al. (1989) demonstrated significant down regulation of cortical β-adrenergic receptors by co-administration of desipramine (DMI), a norepinephrine uptake inhibitor, and the full 5-HT 1A agonist 8-OH-DPAT. To this end, the effects of acute and chronic (4 and 14 day) administration of DMI, gepirone, a selective 5-HT 1A post-synaptic partial agonist, as well as a combination of the two, on cortical (±)-propranolol sensitive [ 3 H]-DHA binding sites were examined in rats. Down regulation was apparent after 4 and 14 day treatment with DMI. However, this was not the case with gepirone. Of particular importance is the demonstration of a greater magnitude of down regulation with co-administration of a greater magnitude of down regulation with co-administration of DMI and gepirone. These results suggests that alteration in rat cortical (±)-propranolol sensitive [ 3 H]-DHA binding sites by noradrenergic uptake inhibitors can be further modulated by selective partial agonist activity at central 5-HT 1A postsynaptic receptors. Further data on the co-administration of DMI and BMY 7378 (7,9-dioxo-8-[2-(4-o-methoxyphenylpiperazinyl)ethyl]-8-azaspiro[4,5]decane dihydrochloride), a weak partial agonist at postsynaptic 5-HT 1A receptors, are also presented

  14. NAICS Sector 92: Public Administration

    Science.gov (United States)

    Find the public administration industries EPA regulations affect, with their North American Industry Classification System (NAICS) code. On those pages you can find a list of laws and regulations that affect your industry as well as compliance information

  15. 29 CFR 541.200 - General rule for administrative employees.

    Science.gov (United States)

    2010-07-01

    ... REGULATIONS DEFINING AND DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES Administrative Employees § 541.200 General rule for administrative employees. (a...

  16. Coerência dos sistemas social e jurídico e regulação das autogestões em saúde suplementar / Coherence of social and legal systems and self-administrations regulation in supplementary health

    Directory of Open Access Journals (Sweden)

    Jaqueline Resende Candido Mello

    2017-04-01

    Full Text Available Purpose – The present study deals with self-administrations in supplementary health and analyzes to what extent sectoral regulation has observed the specific culture of the regulated business. In order to do so, it presents a historical and cultural contextualization of the self-administrations and the normative of the sector, in addition to analogy with the closed private pension entities. Methodology/approach/design – It is based on the theory of autopoiesis and Teubner's Regulatory Trilemma, which are informed in the initial sections. Next, analysis of norms affected to self-administrations in supplementary health and a comparative approach in relation to closed private pension entities. Findings – To the extent that the legal system and the social system regulated are not coherent with each other, since they are not observed, regulatory action can fail. In the case of self-administrations, regulatory action may disintegrate this system if it does not observe its distinct nature and, consequently, does not preserve the culture of the business.

  17. 48 CFR 3028.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administration. 3028.106 Section 3028.106 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY... 3028.106 Administration. ...

  18. Analysis of experience of legal regulation in the sphere of public administration of sanatorium providing of children in the Russian Federation

    Directory of Open Access Journals (Sweden)

    Kovalenko T.Yu.

    2014-03-01

    Full Text Available Motherhood and childhood are one of the main priorities of the government social policy for any country. The Ukrainian state, its President and government are keeping under scrutiny issues of improving quality of life and health of population, in particular, health of women and children. Continuing study of problems of Public Administration in the sphere of health resort services for children in Ukraine, in her previous scientific publications the author drew attention to insufficient scope of researches and weak grounds of theoretical justification of possible organizational changes in this sphere. This very fact stipulates the necessity to continue thorough scientific research and study, first of all, a positive experience of foreign countries as to implementing reforms in the sphere of health resort services for children. The share of separate factors of different nature, impacting indicators of public health depends on age, sex and individual-typological characteristics of a person. However, the greatest impact on a human health is made by his lifestyle that may be attributed to conditionally controlled process. In this case, it is appropriate to note that the controlled impact on lifestyle can be made both by internal factors (e.g., motivation, and external factors. One of the most powerful external factors of controlled impact on the public health is health resort provision. The experience of the Russian Federation in this area is extremely useful for the Ukrainian state, which is actively promoting the idea of the health system modernization in the domestic market as the area in need of such changes. Now, 1997 health resorts are operating in the Russian Federation, annually serving approximately 6 million people. The jurisdiction of the Ministry of Health and Social Development of the Russian Federation encompasses 51 health resort facilities (HRF providing a wide range of health-improving services. The laws, government regulations

  19. [Italian Decree D.lgs 231/2001--"Regulations regarding administrative responsibilities of corporate bodies of Companies and Associations including those not legally recognized"--an organizational model for the healthcare area].

    Science.gov (United States)

    Roberti, Giovanni; Fiore, Rosalia; Franco, Claudia; Pimpinella, Giovanni; Piscioneri, Patrizia

    2010-01-01

    Healthcare organizations must implement organizational and management models of regulation and control systems for effectively preventing possible administrative torts by personnel. We define an organizational management and control model for healthcare organizations, based on the legal dispositions of Decree n.231/2001. The model identifies critical points in the administrative and healthcare services delivery processes that are at high-risk of violations to the code. Its primary aim is to prevent torts by the personnel and safeguard the organization at the same time.

  20. Respectful doubts on the new ICRP recommendations

    International Nuclear Information System (INIS)

    Diaz de la Cruz, F.

    1992-01-01

    The admiration and deference an International Organization, as ICRP, deserves not only by its altruistic mission but also by the eminent and distinguished scientists who work for it, in some way 'dazzles' to simple students of its theories and, in some way 'force' us to accept, sometimes without any critical, serious and previous meditation, its recommendations. But it is not the bad thing this kind of 'blindness' we have before the almighty ...ICRP dixit..., the worst thing is that non-specialist and non-specialized persons believe as 'dogmas' and 'axioms' the ICRP recommednations and make of them legal dispositions through standards and regulations. Standards an regulations which can frustate an industrial or any other type of peaceful nuclear activity due to the economic or the social reasons derived from ICRP recommendations. The inflexibility (weakened in the arguments but strengthened in the recommendations) of this influent Organism on the 'linearity without threshold' in the dose-effect relationship and the compromises of the International Labor Organization (ILO) with respect ICRP recommedations provole irrational, ilogical and non desirable answers. (author)

  1. The Art of Administration.

    Science.gov (United States)

    Borelli, Frank L.

    1984-01-01

    Presents ten guidelines for human relations skills that can help elevate the practice of student personnel administration to an art form. Administrators need to develop and perfect leadership skills including respect for individual differences, consistency, listening skills, instinct, being a role model, and establishment of realistic performance…

  2. Assumptions used in determining the radiation exposure according to the amended Radiation Protection Ordinance, and required adjustments in the General Administrative Regulation relating to paragraph 45 of the Radiation Protection Ordinance

    International Nuclear Information System (INIS)

    Wirth, E.

    2000-01-01

    Within the framework of the amendment of the Radiation Protection Ordinance, the need arises to also amend the General Administrative Regulation on calculation of the radiation exposure due to radioactivity release with gaseous or liquid effluents, for the purpose of verification of compliance with the dose limits given in section 45 of the Radiation Protection Ordinance. The General Administrative regulation has to be harmonized with European legislation, EURATOM Directive 96/29. The required consultations for decision making have been a task of the working group for 'Anpassung der radiooekologischen Berechnungsgrundlage', of the Radioecology Committee of the SSK. The paper discusses the resulting draft document for amendment presented to and accepted by the SSK Committee. The document is awaiting discussion for final decision among members of the SSK, and between the SSK and representatives of Land governments as well as various bodies representing interests. (orig./CB) [de

  3. Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats.

    Science.gov (United States)

    Ardiansyah; Ohsaki, Yusuke; Shirakawa, Hitoshi; Koseki, Takuya; Komai, Michio

    2008-04-23

    We studied the effects of a single oral administration of ferulic acid (FA) on the blood pressure (BP) and lipid profile in stroke-prone spontaneously hypertensive rats (SHRSP). Male 12-week-old SHRSP were administered FA (9.5 mg/kg of body weight) and distilled water as the control (C) (1 mL) via a gastric tube. The hypotensive effect of FA was observed at the lowest value after 2 h administration. A decrease in the angiotensin-1-converting enzyme (ACE) activity in the plasma corresponded well with the reduction of BP. Plasma total cholesterol and triglyceride levels were lower after 2 h administration. The mRNA expression of genes involved in lipid and drug metabolism was downregulated in the FA group. These results suggest that oral administration of FA appears beneficial in improving hypertension and hyperlipidemia.

  4. Administrating Solr

    CERN Document Server

    Mohan, Surendra

    2013-01-01

    A fast-paced, example-based guide to learning how to administrate, monitor, and optimize Apache Solr.""Administrating Solr"" is for developers and Solr administrators who have a basic knowledge of Solr and who are looking for ways to keep their Solr server healthy and well maintained. A basic working knowledge of Apache Lucene is recommended, but this is not mandatory.

  5. Administrative Synergy

    Science.gov (United States)

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  6. Administrative Circulars

    CERN Document Server

    Département des Ressources humaines

    2004-01-01

    Administrative Circular N° 2 (Rev. 2) - May 2004 Guidelines and procedures concerning recruitment and probation period of staff members This circular has been revised. It cancels and replaces Administrative Circular N° 2 (Rev. 1) - March 2000. Administrative Circular N° 9 (Rev. 3) - May 2004 Staff members contracts This circular has been revised. It cancels and replaces Administrative Circular N° 9 (Rev. 2) - March 2000. Administrative Circular N° 26 (Rev. 4) - May 2004 Procedure governing the career evolution of staff members This circular has also been revised. It Administrative Circulars Administrative Circular N° 26 (Rev. 3) - December 2001 and brings up to date the French version (Rev. 4) published on the HR Department Web site in January 2004. Operational Circular N° 7 - May 2004 Work from home This circular has been drawn up. Operational Circular N° 8 - May 2004 Dealing with alcohol-related problems...

  7. 5 CFR 831.101 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Administration. 831.101 Section 831.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.101 Administration. (a) OPM has charge of the...

  8. 7 CFR 56.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 56.3 Section 56.3 Agriculture... EGGS Grading of Shell Eggs General § 56.3 Administration. The Administrator shall perform, for and... administration of the provisions of the Act and the regulations in this part. The Administrator is authorized to...

  9. 5 CFR 179.307 - Administrative offset.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Administrative offset. 179.307 Section 179.307 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Administrative Offset § 179.307 Administrative offset. (a) If the debtor does not...

  10. Administrative Reform

    DEFF Research Database (Denmark)

    Plum, Maja

    Through the example of a Danish reform of educational plans in early childhood education, the paper critically addresses administrative educational reforms promoting accountability, visibility and documentation. Drawing on Foucaultian perspectives, the relation between knowledge and governing...... of administrative technology, tracing how the humanistic values of education embed and are embedded within ‘the professional nursery teacher' as an object and subject of administrative practice. Rather than undermining the humanistic potential of education, it is argued that the technology of accounting...

  11. [Respecting minors' autonomy in child custody cases].

    Science.gov (United States)

    Santa Rosa, Bárbara; Corte-Real, Francisco; Vieira, Duarte Nuno

    2013-01-01

    Child custody decisions are among the most difficult for judges to make. The possibility of child abuse allegations or parents' deviant/ psychopathologic behaviours within this context, make the decision further complicated. Based on jurisprudence the listening of children opinion is a way to protect their best interest. In fact children have the right to express an opinion in all matters affecting their life. It should be given proper consideration to children opinion according with his/her age and maturity. Nonetheless custody disputes are emotionally draining issues. Asking the child to express an opinion during a public hearing, most likely in the presence of both parents, its not recommended because this is a potential stressful experience. Child interviews should take place in a proper environment and be set to their age. Medicine and Psychology have an important role in assessing children cognitive, emotional and volitional abilities, which is essential to properly account their opinions according to autonomy degree. This essay analyses the contribution of medico-legal and/or psychological exams to respect the autonomy of the child in cases of regulation of parental responsibilities. The conclusion is the need to establish a symbiotic relationship between the medical and legal perspectives of the (open) concept of child's best interests.

  12. Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors.

    Science.gov (United States)

    Kawahara, Tomohiro; Makizaki, Yutaka; Oikawa, Yosuke; Tanaka, Yoshiki; Maeda, Ayako; Shimakawa, Masaki; Komoto, Satoshi; Moriguchi, Kyoko; Ohno, Hiroshi; Taniguchi, Koki

    2017-01-01

    Human rotavirus (RV) infection is a leading cause of dehydrating diarrhea in infants and young children worldwide. Since therapeutic approaches to RV gastroenteritis are limited to alleviation of dehydration with oral rehydration solutions, more direct approaches to palliate symptoms of RV gastroenteritis are required. Treatments with probiotics have been increasingly recognized as alternative safe and low cost treatments for moderate infectious diarrhea. In this study, Bifidobacterium bifidum G9-1 (BBG9-1), which has been used as an intestinal drug for several decades, was shown to have a remarkable protective effect against RV gastroenteritis in a suckling mice model. As well as prophylactic oral administration of BBG9-1 from 2 days before RV infection, therapeutic oral administration of BBG9-1 from 1 day after RV infection significantly alleviated RV-induced diarrhea. Therapeutic administration of BBG9-1 reduced various types of damage in the small intestine, such as epithelial vacuolization and villous shortening, and significantly diminished the infectious RV titer in mixtures of cecal contents and feces. It was also shown that therapeutic administration of BBG9-1 significantly increased the number of acidic mucin-positive goblet cells and the gene expression of mucosal protective factors including MUC2, MUC3, MUC4, TGFβ1 and TFF3 in the small intestine. This led to alleviation of low gut permeability shown as decreased gene expression levels of occludin, claudin-1 and villin-1 after RV infection. Furthermore, in the small intestine, therapeutic administration of BBG9-1 significantly palliated the decreased gene expression of SGLT-1, which plays an important role in water absorption. In the large intestine, administered BBG9-1 was shown to replicate to assimilate undigested nutrients, resulting in normalization of the abnormally high osmotic pressure. These results suggested that water malabsorption caused by RV infection was alleviated in mice administered

  13. Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors.

    Directory of Open Access Journals (Sweden)

    Tomohiro Kawahara

    Full Text Available Human rotavirus (RV infection is a leading cause of dehydrating diarrhea in infants and young children worldwide. Since therapeutic approaches to RV gastroenteritis are limited to alleviation of dehydration with oral rehydration solutions, more direct approaches to palliate symptoms of RV gastroenteritis are required. Treatments with probiotics have been increasingly recognized as alternative safe and low cost treatments for moderate infectious diarrhea. In this study, Bifidobacterium bifidum G9-1 (BBG9-1, which has been used as an intestinal drug for several decades, was shown to have a remarkable protective effect against RV gastroenteritis in a suckling mice model. As well as prophylactic oral administration of BBG9-1 from 2 days before RV infection, therapeutic oral administration of BBG9-1 from 1 day after RV infection significantly alleviated RV-induced diarrhea. Therapeutic administration of BBG9-1 reduced various types of damage in the small intestine, such as epithelial vacuolization and villous shortening, and significantly diminished the infectious RV titer in mixtures of cecal contents and feces. It was also shown that therapeutic administration of BBG9-1 significantly increased the number of acidic mucin-positive goblet cells and the gene expression of mucosal protective factors including MUC2, MUC3, MUC4, TGFβ1 and TFF3 in the small intestine. This led to alleviation of low gut permeability shown as decreased gene expression levels of occludin, claudin-1 and villin-1 after RV infection. Furthermore, in the small intestine, therapeutic administration of BBG9-1 significantly palliated the decreased gene expression of SGLT-1, which plays an important role in water absorption. In the large intestine, administered BBG9-1 was shown to replicate to assimilate undigested nutrients, resulting in normalization of the abnormally high osmotic pressure. These results suggested that water malabsorption caused by RV infection was alleviated in

  14. An investigation into the receptor-regulating effects of the acute administration of opioid agonists and an antagonist on beta adrenergic receptors in the rat cerebral cortex

    International Nuclear Information System (INIS)

    Roper, I.

    1987-01-01

    Past and current research indicated that biochemical deviations which might be involved in the etiology and pathophysiology of depression, included abnormalities or imbalances in the noradrenergic, serotonergic, hormonal and possibly in the endogenous opioid, dopaminergic, histaminergic, cholinergic and trace amine systems. In order to investigate a possible link between the noradrenergic system and opioids, it was decided to test the acute effects of opioid administration on cortical beta adrenoceptor numbers and affinity. As these receptors have been most consistently downregulated by antidepressant treatment, they may be involved in the mechanism of antidepressant action of these agents. It was decided to investigate beta adrenoceptor-regulatory effects of opioid treatment. Naloxone was tested alone, with a view to suppressing any possible endogenous opioid influences upon beta receptor status and revealing an effect which would possibly be the opposite of that brought about by the administration of opioid agonists. Naloxone was administered together with morphine to demonstrate that any beta receptor up- or downregulation which might be measured, had indeed been opioid-receptor mediated. It was found that the acute administration of four different mu opioid agonists, naloxone and naloxone plus morphine, did not cause any statistically significant alterations in cortical beta adrenergic receptor numbers or affinity in the rat. A radioactive ligand, the beta adrenoceptor-labelling compound referred to as DHA (L-dihydroalprenolol HCI) was used in this study

  15. Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17 beta-estradiol administration

    NARCIS (Netherlands)

    Gerrits, M.; Westenbroek, C.; Koch, T.; Grootkarzijn, A.; Ter Horst, G. J.

    2006-01-01

    Chronic stress induced neuronal changes that may have consequences for subsequent stress responses. For example, chronic stress in rats rearranges dendritic branching patterns and disturbs the phosphorylation of extracellular-regulated kinase 1 and 2 (ERK) 1/2 throughout the limbic system.

  16. Gemfibrozil and Fenofibrate, Food and Drug Administration-approved Lipid-lowering Drugs, Up-regulate Tripeptidyl-peptidase 1 in Brain Cells via Peroxisome Proliferator-activated Receptor α

    Science.gov (United States)

    Ghosh, Arunava; Corbett, Grant T.; Gonzalez, Frank J.; Pahan, Kalipada

    2012-01-01

    The classical late infantile neuronal ceroid lipofuscinosis (LINCLs) is an autosomal recessive disease, where the defective gene is Cln2, encoding tripeptidyl-peptidase I (TPP1). At the molecular level, LINCL is caused by accumulation of autofluorescent storage materials in neurons and other cell types. Currently, there is no established treatment for this fatal disease. This study reveals a novel use of gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, in up-regulating TPP1 in brain cells. Both gemfibrozil and fenofibrate up-regulated mRNA, protein, and enzymatic activity of TPP1 in primary mouse neurons and astrocytes as well as human astrocytes and neuronal cells. Because gemfibrozil and fenofibrate are known to activate peroxisome proliferator-activated receptor-α (PPARα), the role of PPARα in gemfibrozil- and fenofibrate-mediated up-regulation of TPP1 was investigated revealing that both drugs up-regulated TPP1 mRNA, protein, and enzymatic activity both in vitro and in vivo in wild type (WT) and PPARβ−/−, but not PPARα−/−, mice. In an attempt to delineate the mechanism of TPP1 up-regulation, it was found that the effects of the fibrate drugs were abrogated in the absence of retinoid X receptor-α (RXRα), a molecule known to form a heterodimer with PPARα. Accordingly, all-trans-retinoic acid, alone or together with gemfibrozil, up-regulated TPP1. Co-immunoprecipitation and ChIP studies revealed the formation of a PPARα/RXRα heterodimer and binding of the heterodimer to an RXR-binding site on the Cln2 promoter. Together, this study demonstrates a unique mechanism for the up-regulation of TPP1 by fibrate drugs via PPARα/RXRα pathway. PMID:22989886

  17. Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy.

    Science.gov (United States)

    Ghosh, Arunava; Corbett, Grant T; Gonzalez, Frank J; Pahan, Kalipada

    2012-11-09

    The classical late infantile neuronal ceroid lipofuscinosis (LINCLs) is an autosomal recessive disease, where the defective gene is Cln2, encoding tripeptidyl-peptidase I (TPP1). At the molecular level, LINCL is caused by accumulation of autofluorescent storage materials in neurons and other cell types. Currently, there is no established treatment for this fatal disease. This study reveals a novel use of gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, in up-regulating TPP1 in brain cells. Both gemfibrozil and fenofibrate up-regulated mRNA, protein, and enzymatic activity of TPP1 in primary mouse neurons and astrocytes as well as human astrocytes and neuronal cells. Because gemfibrozil and fenofibrate are known to activate peroxisome proliferator-activated receptor-α (PPARα), the role of PPARα in gemfibrozil- and fenofibrate-mediated up-regulation of TPP1 was investigated revealing that both drugs up-regulated TPP1 mRNA, protein, and enzymatic activity both in vitro and in vivo in wild type (WT) and PPARβ(-/-), but not PPARα(-/-), mice. In an attempt to delineate the mechanism of TPP1 up-regulation, it was found that the effects of the fibrate drugs were abrogated in the absence of retinoid X receptor-α (RXRα), a molecule known to form a heterodimer with PPARα. Accordingly, all-trans-retinoic acid, alone or together with gemfibrozil, up-regulated TPP1. Co-immunoprecipitation and ChIP studies revealed the formation of a PPARα/RXRα heterodimer and binding of the heterodimer to an RXR-binding site on the Cln2 promoter. Together, this study demonstrates a unique mechanism for the up-regulation of TPP1 by fibrate drugs via PPARα/RXRα pathway.

  18. Considerations pertaining to cell collection and administration of industry-manufactured autologous CAR-T cells, in relation to French healthcare organization and regulations.

    Science.gov (United States)

    Chabannon, Christian; Larghero, Jérôme

    2018-05-01

    Access to treatment with CAR-T Cells at European hospitals in general and at French hospitals in particular remains limited, when compared with the situation that prevails in the USA or in certain Asian countries. Multiple reasons explain why European investigators lag behind their US or Chinese colleagues in this clinical research area. Some of these reasons are related to the European and French regulatory landscapes that hamper the design and rapid implementation of organizational solutions needed for safe and efficient administration of CAR-T Cells. We here identify some of these pressing issues and propose some possible paths to move forward. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  19. Offentlig administration

    DEFF Research Database (Denmark)

    Nielsen, Elof Nellemann; Rehr, Preben René

    En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer.......En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer....

  20. SAT administrator

    International Nuclear Information System (INIS)

    Havas, A.

    1998-01-01

    SAT Administrator is the Information System for Nuclear Power Plant Personnel Training Program Design. It supports the design of training programs in the following phases: job analysis; task analysis; competency analysis; task competency association; definition of learning objectives to competencies; training program design; definition of test items. The general structure of the database and management software supports application of the SAT Administrator in any nuclear power installation

  1. 7 CFR 57.10 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 57.10 Section 57.10 Agriculture... PRODUCTS INSPECTION ACT) Regulations Governing the Inspection of Eggs General § 57.10 Administration. The... require in the enforcement or administration of the provisions of the act and the regulations in this part...

  2. Civil Law Obligations in the Financial Law Regulations A seminar at the Faculty of Law and Administration, Torun, 24 March 2015

    Directory of Open Access Journals (Sweden)

    Mirosław Bączyk

    2015-06-01

    Full Text Available The problem, which is examined in the study, is the legal way of creation of civil law obligations. Civil law obligations are created by civil law transactions (especially by contracts. There is the question, if civil law obligations can be created directly by the legal regulations? This issue is important for the legal and financial relations between the Treasury, local government and other legal persons.

  3. Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

    OpenAIRE

    Kim, Jongwan; Yun, Eun-Young; Quan, Fu-Shi; Park, Seung-Won; Goo, Tae-Won

    2017-01-01

    The α-glucosidase inhibitor, 1-deoxynojirimycin (DNJ), is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Result...

  4. Incidence of Listeria spp. in Ready-to-Eat Food Processing Plant Environments Regulated by the U.S. Food Safety and Inspection Service and the U.S. Food and Drug Administration.

    Science.gov (United States)

    Reinhard, Robert G; Kalinowski, Robin M; Bodnaruk, Peter W; Eifert, Joseph D; Boyer, Renee R; Duncan, Susan E; Bailey, R Hartford

    2018-06-07

    A multiyear survey of 31 ready-to-eat (RTE) food processing plants in the United States was conducted to determine the incidence of Listeria spp. in various RTE production environments. Samples were collected from 22 RTE plants regulated by the U.S. Department of Agriculture's Food Safety and Inspection Service (FSIS) and from 9 RTE food plants regulated by the U.S. Department of Health and Human Services' Food and Drug Administration (FDA). Only nonfood contact surfaces in the RTE manufacturing areas with exposed RTE product were sampled. Each sample was individually analyzed for the presence of Listeria spp. by using a PCR-based rapid assay. In total, 4,829 samples were collected from various locations, including freezers, equipment framework, floors, walls, wall-floor junctures, drains, floor mats, doors, and cleaning tools. Nine (29%) of the facilities had zero samples positive for Listeria spp. in the production environment, whereas 22 (71%) had one or more samples positive for Listeria spp. The total incidence of Listeria spp. in all RTE food plants was 4.5%. The positive rate in plants regulated by the FSIS ranged from 0 to 9.7%, whereas the positive rate in plants regulated by the FDA ranged from 1.2 to 36%.

  5. 48 CFR 228.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 228.106 Section 228.106 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.106 Administration. ...

  6. 48 CFR 53.242 - Contract administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract administration. 53.242 Section 53.242 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.242 Contract administration. ...

  7. Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Δ9-tetrahydrocannabinol on spatial memory.

    Science.gov (United States)

    Sousa, Vasco C; Assaife-Lopes, Natália; Ribeiro, Joaquim A; Pratt, Judith A; Brett, Ros R; Sebastião, Ana M

    2011-01-01

    The cannabinoid CB(1) receptor-mediated modulation of γ-aminobutyric acid (GABA) release from inhibitory interneurons is important for the integrity of hippocampal-dependent spatial memory. Although adenosine A(1) receptors have a central role in fine-tuning excitatory transmission in the hippocampus, A(1) receptors localized in GABAergic cells do not directly influence GABA release. CB(1) and A(1) receptors are the main targets for the effects of two of the most heavily consumed psychoactive substances worldwide: Δ(9)-tetrahydrocannabinol (THC, a CB(1) receptor agonist) and caffeine (an adenosine receptor antagonist). We first tested the hypothesis that an A(1)-CB(1) interaction influences GABA and glutamate release in the hippocampus. We found that A(1) receptor activation attenuated the CB(1)-mediated inhibition of GABA and glutamate release and this interaction was manifested at the level of G-protein activation. Using in vivo and in vitro approaches, we then investigated the functional implications of the adenosine-cannabinoid interplay that may arise following chronic caffeine consumption. Chronic administration of caffeine in mice (intraperitoneally, 3 mg/kg/day, for 15 days, >12 h before trials) led to an A(1)-mediated enhancement of the CB(1)-dependent acute disruptive effects of THC on a short-term spatial memory task, despite inducing a reduction in cortical and hippocampal CB(1) receptor number and an attenuation of CB(1) coupling with G protein. A(1) receptor levels were increased following chronic caffeine administration. This study shows that A(1) receptors exert a negative modulatory effect on CB(1)-mediated inhibition of GABA and glutamate release, and provides the first evidence of chronic caffeine-induced alterations on the cannabinoid system in the cortex and hippocampus, with functional implications in spatial memory.

  8. 7 CFR 29.51 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Administration. 29.51 Section 29.51 Agriculture... INSPECTION Regulations Administration § 29.51 Administration. The Director is charged with the supervision of the Division and the performance of all duties assigned thereto in the administration of the Act...

  9. 9 CFR 354.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Administration. 354.3 Section 354.3... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Administration § 354.3 Administration... prescribed in the regulations in this part and as the Secretary may require in the administration of the...

  10. 9 CFR 381.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Administration. 381.3 Section 381.3... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Administration; Application of Inspection and Other Requirements § 381.3 Administration. (a) [Reserved] (b) The Administrator may in specific classes of cases...

  11. 7 CFR 253.4 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 253.4 Section 253.4 Agriculture... GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS § 253.4 Administration. (a) Federal administration. Within the Department...

  12. 7 CFR 800.2 - Administrator.

    Science.gov (United States)

    2010-01-01

    ... which would not impair the objectives of the Act, suspend for period determined by the Administrator any... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Administration... administration of the United States Grain Standards Act and responsibilities under the Agricultural Marketing Act...

  13. Research on the Transformation of Administrative Law in Online Market Regulation in China%论我国网络市场监管的行政法治转型

    Institute of Scientific and Technical Information of China (English)

    程琥

    2017-01-01

    The transformation of administrative law in online market regulation is under the background of the current social transformation and rule of law transformation in our country.“Innovation, coordination, greenness, openness and sharing” is the five development ideas put forward by the fifth plenary session of the 18th CPC central committee. China's online market regulation is faced with problem of innovation, coordination, greenness, openness and sharing. The ultimate goal is to achieve the transformation from the network management to the network governance, from the administrative supervision to the legal regulation, from unitary management to multiple coordination, from local governance to global governance, and from power-based system to rights-based system. The transformation of administrative law in the online market regulation is an important guarantee to promote the prosperity, stability and healthy development of the online market. It is also an inevitable requirement to implement the five development ideas and build a government under the rule of law.%网络市场监管的行政法治转型是在我国当前社会转型和法治转型的背景下出现的。“创新、协调、绿色、开放、共享”是党的十八届五中全会提出的的五大发展理念,我国网络市场监管面临着创新性、协调性、绿色性、开放性、共享性转型,从而推动网络市场监管实现从网络管理到网络治理、从行政监管到法治监管、从一元管理到多元协同、从本土治理到全球治理、从权力本位到权利本位的五大转型。加强网络市场监管的行政法治转型是促进网络市场繁荣、稳定、健康发展的重要保证,也是落实五大发展理念、建设法治政府的必然要求。

  14. International Health Regulations (2005 facilitate communication for in-flight contacts of a Middle East respiratory syndrome case, Hong Kong Special Administrative Region, 2014

    Directory of Open Access Journals (Sweden)

    Poon Kwok-ming

    2015-03-01

    Full Text Available The International Health Regulations (IHR (2005 require World Health Organization Member States to notify events fulfilling two of four criteria: (1 serious public health impact; (2 unusual or unexpected event; (3 significant risk of international spread; or (4 significant risk of international travel or trade restrictions.1 In-flight transmission of infections like severe acute respiratory syndrome is well documented.2 With the enormous amount of air travel today, the risk of increasing in-flight transmission and subsequent international spread of infections are increasing. Prompt notification and information sharing under the IHR mechanism is critical for effective contact tracing and prompt control measures. We report on a case of in-flight exposure to an infection with significant public health risks that was successfully resolved using IHR (2005 guidelines.

  15. 29 CFR 541.402 - Executive and administrative computer employees.

    Science.gov (United States)

    2010-07-01

    ... LABOR REGULATIONS DEFINING AND DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES Computer Employees § 541.402 Executive and administrative computer...

  16. Administrative circular

    CERN Multimedia

    2003-01-01

    • N° 21 - August 2003 Special leave This circular has been amended. Copies of this circular are available in the Divisional Secretariats. In addition, administrative and operational circulars, as well as the lists of those in force, are available for consultation on the Web at: http://cern.ch/hr-div/internal/admin_services/admincirc/listadmincirc.asp Human Resources Division Tel. 74128

  17. Database Administrator

    Science.gov (United States)

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  18. Administrative IT

    Science.gov (United States)

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  19. Environmental recordkeeping: The administrative record

    International Nuclear Information System (INIS)

    Sprouse, B.S.

    1991-08-01

    This document provides information on an environmental records management system. It includes information on environmental recordkeeping; environmental regulations with emphasis on the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA); and the administrative record including a case study of the Hanford Site's administrative record system. This paper will focus on the following objectives: (1) Identify resources that can be used as reference tools; (2) understand the reasons for developing and maintaining an administrative record; and, (3) evaluate an existing system and identify means of complying with the regulations. 15 refs., 2 figs

  20. Environmental recordkeeping: The administrative record

    Energy Technology Data Exchange (ETDEWEB)

    Sprouse, B.S.

    1991-08-01

    This document provides information on an environmental records management system. It includes information on environmental recordkeeping; environmental regulations with emphasis on the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA); and the administrative record including a case study of the Hanford Site's administrative record system. This paper will focus on the following objectives: (1) Identify resources that can be used as reference tools; (2) understand the reasons for developing and maintaining an administrative record; and, (3) evaluate an existing system and identify means of complying with the regulations. 15 refs., 2 figs.

  1. Equality, self‐respect and voluntary separation

    NARCIS (Netherlands)

    Merry, M.S.

    2012-01-01

    This paper argues that self‐respect constitutes an important value, and further, an important basis for equality. It also argues that under conditions of inequality‐producing segregation, voluntary separation in schooling may be more likely to provide the resources necessary for self‐respect. A

  2. The "déjà vu effect:" evaluation of United States medical device legislation, regulation, and the Food and Drug Administration's contentious 510(k) program.

    Science.gov (United States)

    Bauman, Jordan

    2012-01-01

    With the Medical Device Amendments of 1976, Congress granted FDA authority to regulate medical devices by implementing a risk-based regulatory framework. Several years prior to this legislation, the Cooper Committee reviewed the medical device regulatory landscape and uncovered weaknesses that could be detrimental to public health. However, only after several high-profile incidents involving unsafe medical devices did Congress respond with strong legislation. Since 1976, additional medical device legislative revisions have been enacted to address deficiencies highlighted by various groups representing Congress, FDA, and industry. A repetitive conclusion from these groups has been that the 510(k) program is incapable of serving as a premarket evaluation of safety and effectiveness under the existing statutory framework. However, these legislative revisions did not change the statutory framework despite these repeated findings. In 2009, CDRH convened separate groups to again review the 510(k) program. While more comprehensive than previous initiatives, the observed deficiencies and the proposed recommendations are remarkably similar to those identified by their predecessors. This cyclical review of the medical device regulatory landscape whereby the same observations and recommendations are repeated yet the output of such review does not yield major legislative revision of the existing statutory framework can be described as the "déjà vu effect." This will continue unless Congress enacts legislation that implements a new statutory framework with a different standard other than substantial equivalence. In the past, Congress has implemented major legislation only after a public health crisis. Hopefully this will not be the driving force in the future.

  3. Administrative litigation systems in Europe

    Directory of Open Access Journals (Sweden)

    Cătălin-Silviu Săraru

    2017-06-01

    Full Text Available The article, analyzing the administrative litigation in the comparative law, groups the existing types of administrative litigation into four major systems, namely: a States with administrative jurisdictions who have the State Council on top, administrative body with consultative and judicial role (the French system; b States with administrative jurisdictions completely separated from the active and consultative administrations (the German system; c States with administrative jurisdictions included in the judicial system; d States with no administrative jurisdiction (English system. The administrative contentious systems analyzed have developed in line with historical evolution and legal traditions and have been continually adapted to the realities existing in each state. The manner in which the administrative contentious is regulated in a State reflects the degree of democratization of that country, the extent to which the citizen enjoys legal safeguards to defend himself against abuses by public authorities. The scientific novelty of this article is to capture the latest trends in the evolution of the administrative contentious systems analyzed. This study aims to provide an easy working tool for reforming administrative litigation on comparative law in states with young democracy. In the research we used the comparative method, the historical and the logical method.

  4. Can we trust module-respect heuristics?

    International Nuclear Information System (INIS)

    Mo, Yuchang

    2013-01-01

    BDD (Binary Decision Diagrams) have proven to be a very efficient tool to assess Fault Trees. However, the size of BDD, and therefore the efficiency of the whole methodology, depends dramatically on the choice of variable ordering. The determination of the best variable ordering is intractable. Therefore, heuristics have been designed to select reasonably good variable orderings. One very important common feature for good static heuristics is to respect modules. In this paper, the notion of module-respect is studied in a systematic way. It is proved that under certain condition there always exists an optimal ordering that respects modules. This condition is that for each module there is always a smallest module BDD and each included module variable appears only once. On the other hand, it is shown that for the trees not satisfying the above sufficient condition the optimal orderings may not be able to be directly generated using module-respect heuristics, even when the shuffling strategy is used.

  5. Freedom of Expression, Deliberation, Autonomy and Respect

    OpenAIRE

    Rostbøll, Christian F.

    2011-01-01

    This paper elaborates on the deliberative democracy argument for freedom of expression in terms of its relationship to different dimensions of autonomy. It engages the objection that Enlightenment theories pose a threat to cultures that reject autonomy and argues that autonomy-based democracy is not only compatible with but necessary for respect for cultural diversity. On the basis of an intersubjective epistemology, it argues that people cannot know how to live on mutually respectful terms w...

  6. Ombud's Corner: Respect in the workplace

    CERN Multimedia

    Sudeshna Datta-Cockerill

    2014-01-01

    Launched in a previous issue of the Bulletin (see here), the 'Respect@CERN' campaign has triggered some rich and varied reactions, and contributions received from colleagues have covered a wide range of themes that extend from the basic “golden rule of treating others as you would have them treat you” to some very specific observations of respectful behaviour in the CERN context.   “To me, respect is the core of all relationships, all exchanges: we cannot work together and achieve results without it,” says one colleague, while another underlines the equally important dimension of projecting and preserving one’s own self-respect where “whether or not we sleep well at night depends on whether or not we feel that we have been true to ourselves that day”. Respect in the workplace is different from everyday respect in that it is based on an “earned privilege where each colleague has been selected for ...

  7. 48 CFR 1322.406 - Administration and enforcement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration and enforcement. 1322.406 Section 1322.406 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Involving Construction 1322.406 Administration and enforcement. ...

  8. 48 CFR 1222.406 - Administration and enforcement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration and enforcement. 1222.406 Section 1222.406 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION... Involving Construction 1222.406 Administration and enforcement. ...

  9. Administrative contracts

    OpenAIRE

    Vukićević-Petković Milica

    2015-01-01

    Administrative contracts are a special type of contract where usually one of the contracting parties is a public law body and which is concluded for the performance of public service and the realization of a public interest. They go a long way since its inception to its eventual final acceptance of all the legal systems. One of the enduring characteristics of this type of contract is their disquised or unnoticed existence. This is why only monitoring their development may lead to a complete u...

  10. Educating student midwives around dignity and respect.

    Science.gov (United States)

    Hall, Jenny S; Mitchell, Mary

    2017-06-01

    There is currently limited information available on how midwifery students learn to provide care that promotes dignity and respect. In recent years the importance of dignity in healthcare and treating people with respect has received considerable emphasis in both a national and international context. The aim of this discussion paper is to describe an educational workshop that enables learning to promote dignity and respect in maternity care. An interactive workshop, using different creative methods as triggers for learning will be described. Provision of learning opportunities for students around dignity and respect is important to ensure appropriate care is provided in practice. The use of creative methods to inspire has contributed to deep learning within participants. An evaluation of the workshop illustrated how learning impacted on participants practice. Data to support this is presented in this paper. The use of creative teaching approaches in a workshop setting appears to provide an effective learning opportunity around dignified and respectful care. These workshops have evoked a deep emotional response for some participants, and facilitators must be prepared for this outcome to ensure a safe space for learning. Copyright © 2017 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  11. Freedom of Expression, Deliberation, Autonomy and Respect

    DEFF Research Database (Denmark)

    Rostbøll, Christian F.

    2011-01-01

    This paper elaborates on the deliberative democracy argument for freedom of expression in terms of its relationship to different dimensions of autonomy. It engages the objection that Enlightenment theories pose a threat to cultures that reject autonomy and argues that autonomy-based democracy...... is not only compatible with but necessary for respect for cultural diversity. On the basis of an intersubjective epistemology, it argues that people cannot know how to live on mutually respectful terms without engaging in public deliberation and develop some degree of personal autonomy. While freedom...... of expression is indispensable for deliberation and autonomy, this does not mean that people have no obligations regarding how they speak to each other. The moral insights provided by deliberation depend on the participants in the process treating one another with respect. The argument is related to the Danish...

  12. Creating a culture of mutual respect.

    Science.gov (United States)

    Kaplan, Kathryn; Mestel, Pamela; Feldman, David L

    2010-04-01

    The Joint Commission mandates that hospitals seeking accreditation have a process to define and address disruptive behavior. Leaders at Maimonides Medical Center, Brooklyn, New York, took the initiative to create a code of mutual respect that not only requires respectful behavior, but also encourages sensitivity and awareness to the causes of frustration that often lead to inappropriate behavior. Steps to implementing the code included selecting code advocates, setting up a system for mediating disputes, tracking and addressing operational system issues, providing training for personnel, developing a formal accountability process, and measuring the results. Copyright 2010 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  13. Respect for autonomy and technological risks

    NARCIS (Netherlands)

    Asveld, L.

    2008-01-01

    Technological developments can undermine the autonomy of the individual. Autonomy is one's ability to make and act upon decisions according to one's own moral framework. Respect for autonomy dictates that risks should not be imposed on the individual without her consent. Technological developments

  14. [Respect of patient's dignity in the hospital].

    Science.gov (United States)

    Duguet, A-M

    2010-12-01

    Every code of ethics of health professionals in France considers the respect of dignity as a fundamental duty. The French 2002 Law on patient rights says that the person has the right to respect of dignity and of private life. After a presentation of the articles of ethics codes regarding dignity, this paper presents recommendations to deliver medical care in situations where dignity might be endangered such as for patients hospitalized in psychiatric services without consent, or for medical examination of prisoners or medical care to vulnerable patients unable to express their will, especially in palliative care or at the end of life. Respect of dignity after death is illustrated by the reflection conducted by the Espace Ethique de l'AP-HP (Paris area hospitals) and in the Chart of the mortuary yard. A survey of the patients' letters of complaint received by the emergency service of the Toulouse University Hospital showed that, in five years, there were 188 letters and 18 pointed out infringements to the dignity of the person. The health professional team is now aware of this obligation, and in the accreditation of the hospitals, the respect of dignity is one of the indicators of the quality of medical care.

  15. Nurturing the Respectful Community through Practical Life

    Science.gov (United States)

    Bettmann, Joen

    2015-01-01

    Joen Bettmann's depiction of practical life exercises as character-building reveals how caring, careful, and independent work leads to higher self-esteem, more concern for others, better understanding for academic learning, and a self-nurturing, respectful classroom community. Particular aspects of movement and silence exercises bring out what…

  16. ADMINISTRATIVE CIRCULARS

    CERN Multimedia

    Division des ressources humaines

    2000-01-01

    N° 2 (Rev. 1) - March 2000Guidelines and procedures concerning recruitment and probation period of staff membersN° 9 (Rev. 2) - March 2000Staff members contractsN° 16 (Rev. 2) - January 2000TrainingN° 30 (Rev. 1) - January 2000Indemnities and reimbursements upon taking up appointment and termination of contractN° 32 - February 2000Principles and procedures governing complaints of harassmentThese circular have been amended (No 2, N° 9, N° 16 and N° 30) or drawn up (N° 32).Copies are available in the Divisional Secretariats.Note:\tAdministrative and operational circulars, as well as the lists of those in force, are available for consultation in the server SRV4_Home in the Appletalk zone NOVELL (as GUEST or using your Novell username and password), volume PE Division Data Disk.The Word files are available in the folder COM, folder Public, folder ADM.CIRC.docHuman Resources DivisionTel. 74128

  17. 7 CFR 1400.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1400.2 Section 1400.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.2 Administration. (a) The regulations in...

  18. 7 CFR 625.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 625.3 Section 625.3 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.3 Administration. (a) The regulations in...

  19. 7 CFR 1434.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1434.2 Section 1434.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... FOR HONEY § 1434.2 Administration. (a) The regulations of this part shall be administered under the...

  20. 48 CFR 1228.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1228.106 Section 1228.106 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1228.106 Administration. ...

  1. 7 CFR 735.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 735.2 Section 735.2 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. (a) FSA will administer all provisions and activities regulated under the Act under the general...

  2. 48 CFR 1028.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1028.106 Section 1028.106 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 1028.106 Administration. ...

  3. 7 CFR 1403.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1403.2 Section 1403.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES DEBT SETTLEMENT POLICIES AND PROCEDURES § 1403.2 Administration...

  4. 7 CFR 735.400 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 735.400 Section 735.400 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. This subpart sets forth the regulations under which DACO may authorize one or more electronic...

  5. 48 CFR 828.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 828.106 Section 828.106 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 828.106 Administration. ...

  6. 48 CFR 2828.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Administration. 2828.106 Section 2828.106 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General Contracting Requirements BONDS AND INSURANCE Bonds 2828.106 Administration. ...

  7. 48 CFR 428.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Administration. 428.106 Section 428.106 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 428.106 Administration. ...

  8. 48 CFR 1328.106 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1328.106 Section 1328.106 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1328.106 Administration. ...

  9. 7 CFR 1470.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1470.2 Section 1470.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF....2 Administration. (a) The regulations in this part will be administered under the general...

  10. 7 CFR 1469.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1469.2 Section 1469.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) The regulations in this part will be administered under the general supervision and direction...

  11. Freedom of Expression, Deliberation, Autonomy, and Respect

    DEFF Research Database (Denmark)

    Rostbøll, Christian Fogh

    for freedom of expression in terms of its relationship to different dimensions of autonomy. In response to the objection that Enlightenment theories pose a threat to cultures that reject autonomy, it is argued that autonomy-based democracy is not only compatible with but necessary for respect for cultural......The strongest versions of the democracy argument for freedom of expression rely on the deliberative conception of democracy. Deliberative democracy entails both an ideal of political autonomy and of autonomous preference formation. This paper elaborates the deliberative democracy argument...... diversity. On the basis of an intersubjective epistemology, I argue that citizens cannot know how to live on mutually respectful terms without engaging in public deliberation. Moreover, to be successful deliberation must foster some degree of personal autonomy, at least the ability to distinguish what...

  12. Understanding Mechanical Design with Respect to Manufacturability

    Science.gov (United States)

    Mondell, Skyler

    2010-01-01

    At the NASA Prototype Development Laboratory in Kennedy Space Center, Fl, several projects concerning different areas of mechanical design were undertaken in order to better understand the relationship between mechanical design and manufacturabiIity. The assigned projects pertained specifically to the NASA Space Shuttle, Constellation, and Expendable Launch Vehicle programs. During the work term, mechanical design practices relating to manufacturing processes were learned and utilized in order to obtain an understanding of mechanical design with respect to manufacturability.

  13. Nurses’ commitment to respecting patient dignity

    Science.gov (United States)

    Raee, Zahra; Abedi, Heidarali; Shahriari, Mohsen

    2017-01-01

    Background: Although respecting human dignity is a cornerstone of all nursing practices, industrialization has gradually decreased the attention paid to this subject in nursing care. Therefore, the present study aimed to investigate nurses’ commitment to respecting patient dignity in hospitals of Isfahan, Iran. Methods: This descriptive-analytical study was conducted in hospitals of Isfahan. Overall, 401 inpatients were selected by cluster sampling and then selected simple random sampling from different wards. Data were collected through a questionnaire containing the components of patient dignity, that is, patient-nurse relationships, privacy, and independence. All items were scored based on a five-point Likert scale. The collected data were analyzed using descriptive statistics and Chi-square tests. P < 0.05 were considered significant in all analyses. Findings: Most patients (91%) scored their relationships with nurses as good. Moreover, 91.8% of the participants described privacy protection as moderate/good. Only 6.5% of the subjects rated it as excellent. The majority of the patients (84.4%) believed their independence was maintained. These subjects also approved of taking part in decision-making. Conclusion: According to our findings, nurses respected patient dignity to an acceptable level. However, the conditions were less favorable in public hospitals and emergency departments. Nursing authorities and policy makers are thus required to introduce appropriate measures to improve the existing conditions. PMID:28546981

  14. Nurses' commitment to respecting patient dignity.

    Science.gov (United States)

    Raee, Zahra; Abedi, Heidarali; Shahriari, Mohsen

    2017-01-01

    Although respecting human dignity is a cornerstone of all nursing practices, industrialization has gradually decreased the attention paid to this subject in nursing care. Therefore, the present study aimed to investigate nurses' commitment to respecting patient dignity in hospitals of Isfahan, Iran. This descriptive-analytical study was conducted in hospitals of Isfahan. Overall, 401 inpatients were selected by cluster sampling and then selected simple random sampling from different wards. Data were collected through a questionnaire containing the components of patient dignity, that is, patient-nurse relationships, privacy, and independence. All items were scored based on a five-point Likert scale. The collected data were analyzed using descriptive statistics and Chi-square tests. P < 0.05 were considered significant in all analyses. Most patients (91%) scored their relationships with nurses as good. Moreover, 91.8% of the participants described privacy protection as moderate/good. Only 6.5% of the subjects rated it as excellent. The majority of the patients (84.4%) believed their independence was maintained. These subjects also approved of taking part in decision-making. According to our findings, nurses respected patient dignity to an acceptable level. However, the conditions were less favorable in public hospitals and emergency departments. Nursing authorities and policy makers are thus required to introduce appropriate measures to improve the existing conditions.

  15. MOTIVATION OF ADMINISTRATIVE ACTS – GUARANTEE OF GOOD ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Adelin Mihai ZĂGĂRIN

    2018-05-01

    Full Text Available The present article deals with the aspects of motivating administrative acts, both doctrinaire and practical, of jurisprudence. The duty of the administration to motivate its decisions is submitted in the Charter of Fundamental Rights of the European Union, art. 41. In the current European legal order, the rationale for administrative acts is considered and refers to one of the most important conditions of validity of the administrative act. The Romanian Constitution ensures and emphasizes the motivation, as it is imposed by the Charter. The realization of this fundamental right to motivate administrative acts is possible by calling upon a set of values from the administration, such as transparency, professionalism and the imposition of high quality standards. Motivation is achieved where we have a good administration, and whether citizens are, among other things, respected fundamental rights and freedoms, access to information is guaranteed and motivated their decisions. Although administrative normative acts are motivated by the administration, examples that show that individual ones are unmotivated or incompletely motivated are enough, which made the various employers legally answer for the non-motivation of their decisions to terminate work relationships with several of the employees. The motivation of administrative acts is necessary, mandatory and must be done with rigor. It is highlighted that inadequate, incomplete or vicious reasoning may result in suspension or even annulment of the administrative act by the court.

  16. 7 CFR 633.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 633.3 Section 633.3 Agriculture... AGRICULTURE LONG TERM CONTRACTING WATER BANK PROGRAM § 633.3 Administration. (a) The regulations in this part... administration and related policy matters. No determination by the State Technical Committee shall compel the...

  17. 48 CFR 243.204 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders. [75 FR 48277, Aug. 10, 2010] ...

  18. 7 CFR 70.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 70.3 Section 70.3 Agriculture... PRODUCTS AND RABBIT PRODUCTS Grading of Poultry Products and Rabbit Products General § 70.3 Administration... Secretary may require in the enforcement or administration of the provisions of the Act and the regulations...

  19. 7 CFR 760.1101 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 760.1101 Section 760.1101 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. (a) This program is administered under the general supervision of the Administrator, Farm Service...

  20. 7 CFR 1465.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1465.2 Section 1465.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... § 1465.2 Administration. (a) Administration and implementation of AMA's conservation provisions for the...

  1. Honour and respect in Danish prisons

    DEFF Research Database (Denmark)

    Laursen, Julie; Laws, Ben

    2017-01-01

    to create accountable and rational actors, who ‘self-manage’, the therapeutic ethos neglects participants’ life experiences and subcultural capital. Open expressions of moral values by prisoners (such as displays of honour and respect) are considered to be cognitive distortions which are dismissed......Using empirical data from prison-based cognitive-behavioural programmes, this article considers how prisoners’ subcultural capital shapes their responses to demands for ‘cognitive self-change’. We argue that accounts of ‘respect’ in the prior literature fail to capture how prisoners react...

  2. 77 FR 40493 - Export Administration Regulations

    Science.gov (United States)

    2012-07-10

    ... introductory text of paragraph (b)(3): Once a mass market classification request is accepted in SNAP-R, you may... supplement No. 3 to part 740 as authorized by Sec. 740.17(b) of the EAR, while the mass market classification... ``digital transfer rate'' at the highest multiplex level exceeding 45 Mb/s. * * * * * 0 4. On page 422, in...

  3. Manager, Grant Administration | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Assist Grant Administration Officers in the review of project approval ... Coordinate program staff training with respect to financial and administrative aspects of ... structure for the EFPs in consultation with Program Managers and the Chief, EFM.

  4. Respect distances. Rationale and means of computation

    Energy Technology Data Exchange (ETDEWEB)

    Munier, Raymond [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Hoekmark, Harald [Clay Technology, Lund (Sweden)

    2004-12-01

    Canisters with spent nuclear fuel can obviously not be located within deformation zones as this might jeopardise their long term mechanical stability and thereby constitute a potential hazard to the biosphere. Less apparent, but equally important, is the fact that earthquakes trigger reactivation, slip, of structures some distance from their hypocentres due to, among many other factors, stress redistribution. Fault slip across a deposition hole might damage the isolation capacity of the canister and thereby jeopardise the overall integrity of the barrier system. Therefore, the following question might be posed: What is the distance from a deformation zone beyond which a canister can be safely emplaced? This respect distance cannot be readily computed because, unknown future events aside, there are some complicated aspects that need to be addressed e.g. degree of conservatism, scale, our ability to model ice sheets and earthquakes, etc. In this report we discuss various aspects of the assignment of respect distances, propose a methodology for its assignment and apply the methodology to the Forsmark Site as a worked example. Our main concern, in the context discussed in this report, is the post glacial faults anticipated to occur after the next glaciations. To properly address conservativeness, analysis of risk, and its implementation in safety analysis, we provide an extensive compilation of our current knowledge on post glacial faults as an appendix.

  5. Respect distances. Rationale and means of computation

    International Nuclear Information System (INIS)

    Munier, Raymond; Hoekmark, Harald

    2004-12-01

    Canisters with spent nuclear fuel can obviously not be located within deformation zones as this might jeopardise their long term mechanical stability and thereby constitute a potential hazard to the biosphere. Less apparent, but equally important, is the fact that earthquakes trigger reactivation, slip, of structures some distance from their hypocentres due to, among many other factors, stress redistribution. Fault slip across a deposition hole might damage the isolation capacity of the canister and thereby jeopardise the overall integrity of the barrier system. Therefore, the following question might be posed: What is the distance from a deformation zone beyond which a canister can be safely emplaced? This respect distance cannot be readily computed because, unknown future events aside, there are some complicated aspects that need to be addressed e.g. degree of conservatism, scale, our ability to model ice sheets and earthquakes, etc. In this report we discuss various aspects of the assignment of respect distances, propose a methodology for its assignment and apply the methodology to the Forsmark Site as a worked example. Our main concern, in the context discussed in this report, is the post glacial faults anticipated to occur after the next glaciations. To properly address conservativeness, analysis of risk, and its implementation in safety analysis, we provide an extensive compilation of our current knowledge on post glacial faults as an appendix

  6. Promoting respect at home and abroad

    CERN Multimedia

    2015-01-01

    This week, I’d like to focus on respect, whether at home, at work or on the international scene. Last week, I had the opportunity to visit the SESAME laboratory in Jordan along with the new European Commissioner for Research, Carlos Moedas. Since taking up his post, Mr Moedas has attached great importance to the role science can play in diplomacy, and the visit was on his initiative.   Through the EU-funded CESSAMag project, CERN is coordinating the provision of magnets and power supplies for the SESAME main ring. The first are currently being tested at CERN by a team involving accelerator scientists from the SESAME members, and all are due to be delivered to SESAME in time for commissioning in the second half of 2016. SESAME, and CERN’s contribution to the project, are well documented in the pages of the Bulletin, but what really impresses when you visit the lab is the diversity of people working there and the degree of mutual respect they show to each other. SESAME will...

  7. Revisiting Respect for Persons in Genomic Research

    Directory of Open Access Journals (Sweden)

    Debra J. H. Mathews

    2014-01-01

    Full Text Available The risks and benefits of research using large databases of personal information are evolving in an era of ubiquitous, internet-based data exchange. In addition, information technology has facilitated a shift in the relationship between individuals and their personal data, enabling increased individual control over how (and how much personal data are used in research, and by whom. This shift in control has created new opportunities to engage members of the public as partners in the research enterprise on more equal and transparent terms. Here, we consider how some of the technological advances driving and paralleling developments in genomics can also be used to supplement the practice of informed consent with other strategies to ensure that the research process as a whole honors the notion of respect for persons upon which human research subjects protections are premised. Further, we suggest that technological advances can help the research enterprise achieve a more thoroughgoing respect for persons than was possible when current policies governing human subject research were developed. Questions remain about the best way to revise policy to accommodate these changes.

  8. Analysis of the incentives and awards regulations for EMAS-organisations at European level and an assessment with respect to their feasibility at domestic level; Anreiz und Belohnungsregelungen fuer EMAS-Organisationen auf europaeischer Ebene und Bewertung hinsichtlich der nationalen Umsetzbarkeit

    Energy Technology Data Exchange (ETDEWEB)

    Behrens, C.; Heck, A.; Wirth, S.

    2003-10-01

    The research-and-development project aims at gathering, systemising and assessing the entirety as well as selected points concerning the promotion of participation to EMAS by the use of incentives and awards regulations as practised in the member states of the European Union. It intends, furthermore, to make proposals for measures and regulations to improve the situation. This research centres on the impact of environment-policy or environmental-law instruments as regulating incentives and awards. The survey involves three different, interlocking methodical approaches: the jurisprudential analysis and interpretation method, secondary analysis and empirical components in the form of polls. The concepts of 'incentive' and 'reward' are used as synonyms. Binding commitments, explicitly promising advantages to organisations applying EMAS are considered to be 'incentives and awards regulations'. Incentives and rewards regulations have - in part - already become an integral part of the EMAS Regulation in domestic Federal law, mainly in the shape of the EMAS-Privilege Regulation (EMAS-PrivilegV). The interpretation of the incentive and rewards regulations in the member states reveals striking similarities: there, one concentrates mainly on environmental information, reduction of fees as well as promotional programmes as instrument categories. Compared to this, the categories of environmental obligations and official handling still experienced a clear, though weaker, preference. Planning instruments, official handling, environmental agreements and most of economic instruments are either not used, marginally used, or little used. As it turns out, the exemplary registration of the public sector, in particular, strongly needs to be upgraded. The instrument of 'official handling' still contains valuable potential for the promotion of EMAS. There is still plenty of room for improvement in the use of the EMAS logo, in spite of the very

  9. Friction Anisotropy with Respect to Topographic Orientation

    Science.gov (United States)

    Yu, Chengjiao; Wang, Q. Jane

    2012-01-01

    Friction characteristics with respect to surface topographic orientation were investigated using surfaces of different materials and fabricated with grooves of different scales. Scratching friction tests were conducted using a nano-indentation-scratching system with the tip motion parallel or perpendicular to the groove orientation. Similar friction anisotropy trends were observed for all the surfaces studied, which are (1) under a light load and for surfaces with narrow grooves, the tip motion parallel to the grooves offers higher friction coefficients than does that perpendicular to them, (2) otherwise, equal or lower friction coefficients are found under this motion. The influences of groove size relative to the diameter of the mating tip (as a representative asperity), surface contact stiffness, contact area, and the characteristic stiction length are discussed. The appearance of this friction anisotropy is independent of material; however, the boundary and the point of trend transition depend on material properties. PMID:23248751

  10. Manger hors norme, respecter les normes

    OpenAIRE

    Régnier, Faustine

    2007-01-01

    Fondée sur un corpus de près de 10 000 recettes de cuisine de la presse féminine française et allemande (1930‑2000), cette contribution met en évidence la façon dont l’exotisme permet de manger hors norme tout en restant dans les normes. Les pratiques culinaires étrangères ne peuvent être adoptées qu’au terme d’un travail de normalisation. Elles sont modifiées de manière à ce que soient respectées les normes du pays d’accueil, par là même mises en œuvre. Elles sont donc conçues comme un ensem...

  11. 5 CFR 179.309 - Additional administrative procedures.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Additional administrative procedures. 179.309 Section 179.309 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Administrative Offset § 179.309 Additional administrative procedures. Nothing...

  12. A workplace marked by respect and understanding

    CERN Multimedia

    2010-01-01

    Integrity, commitment, professionalism, creativity and diversity: five words that each and every one of us at CERN can identify with, because they represent the core values of this Organization. That’s why they have been chosen as the starting point for our new Code of Conduct, which is being launched this week.  A Code of Conduct describes the basic standards and rules of behaviour that we can expect in the workplace, and it is a statement of the way we see our Organization’s values. CERN’s mission is fundamental research in physics: pushing back the frontiers of human knowledge. In support of that mission, we drive innovation, stimulate international collaboration and inspire a rising generation of scientists. We do all this while respecting the highest ethical standards, and it is this aspect of CERN life that the Code of Conduct describes. CERN’s Code of Conduct has been developed through a collaborative and transparent process to foster shared appre...

  13. The regulation of pituitary-thyroid abnormalities by peripheral administration of levothyroxine increased brain-derived neurotrophic factor and reelin protein expression in an animal model of Alzheimer's disease.

    Science.gov (United States)

    Shabani, Sahreh; Farbood, Yaghoob; Mard, Seyyed Ali; Sarkaki, Alireza; Ahangarpour, Akram; Khorsandi, Layasadat

    2018-03-01

    Alzheimer's disease (AD) is associated with decreased serum levels of thyroid hormones (THs), increased levels of thyroid-stimulating hormone (TSH), and decreased protein expression of brain-derived neurotrophic factor (BDNF) and reelin in the hippocampus. In this study, we have evaluated the effect of subcutaneous administration of levothyroxine (L-T 4 ) on levels of THs and TSH as well as protein expression of BDNF and reelin in AD rats. To make an animal model of AD, amyloid-beta peptide (Aβ) plus ibotenic acid were infused intrahippocampally, and rats were treated with L-T 4 and (or) saline for 10 days. The levels of THs and TSH were measured by ELISA kits. Protein synthesis was detected by Western blotting method. Results have been shown that serum level of THs, BDNF, and reelin protein expression in the hippocampus were significantly decreased (P < 0.001) in AD animals and elevated significantly in AD rats treated with L-T 4 (P < 0.01). Data showed that TSH level significantly decreased in AD rats treated with L-T 4 (P < 0.05). These findings indicated that L-T 4 increased BDNF and reelin protein expression by regulation of serum THs and TSH level in Aβ-induced AD rats.

  14. Self-regulation as a type of managerial activity.

    Directory of Open Access Journals (Sweden)

    Anna Algazina

    2017-01-01

    Full Text Available УДК 342.9The subject. In the context of the ongoing administrative reform in the Russian Federation the issue of self-regulation is becoming increasingly important.Introduction of Institute of self-regulation is intended to reduce the degree of state intervention in private spheres of professional activity, to eliminate excessive administrative barriers, reduce government expenditures on regulation and control in their respective areas of operation, which is especially important in the current economic conditions.However, in Russian legal science is no recognized definition of "self-regulation", but a unity of views on the question of the relationship between self-regulation and state regulation of business relations.In this regard, the author attempts to examine the concept of "self-regulation" through the prism of knowledge about public administration.The purpose of the article is to identify the essential features and to articulate the concept of self-regulation by comparing it with other varieties of regulation.Methodology. The methodological basis for the study: general scientific methods (analysis, synthesis, comparison, description; private and academic (interpretation, formal-legal.Results, scope. Based on the analysis allocated in the science of administrative law approaches to the system of public administration justifies the conclusion that the notion "regulation" is specific in relation to the generic concept of "management" and is a kind of management, consisting in the drafting of rules of conduct and sanctions for non-compliance or inadequate performance.In addition, the article highlights the problem of the genesis of self-regulation, building a system of principles of self-regulation, comparison of varieties of self-regulatory organizations among themselves.Conclusions. The comparison of self-regulation other types of regulation (such as state regulation and co-regulation highlighted the essential features of this phenomenon

  15. 48 CFR 22.102-2 - Administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Administration. 22.102-2 Section 22.102-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC... facilities, including requirements for workers in all occupations and skills from local labor market areas or...

  16. Regulative environmental policy. Regulative Umweltpolitik

    Energy Technology Data Exchange (ETDEWEB)

    Goerlitz, A; Voigt, R [Universitaet der Bundeswehr Muenchen, Neubiberg (Germany, F.R.). Fakultaet fuer Sozialwissenschaften; eds.

    1991-01-01

    Regulative policy means those governmental attempts to steer the course of things which can fall back on a certain repertoire of instruments for actions in order to warrant the causal and temporal connection between the making available and the employment of means. The fact that environmental protection needs regulative policy is substantiated by the thesis that the market has failed; consequently only government can manage the public goods 'environment' in a suitable way, and it is a matter of fact that environmental protection at present is operated preferably via regulative policy. The problems of regulative enviromental policy are manifold. Its implementation often miscarries because of limited administrative resources on the one hand - making sufficient control impossible for instance -, and because of poor quality regulative instruments on the other hand. One way out would be to increase the efficiency of regulative policy by sophisticating judicial techniques. Other ways out point to the executing level and aim at improving implementation strategies or are concerned with post-regulative law. The latter refers to a new legal quality which demonstrates itself already in corporatistical crisis regulation or in induction programs such as pollution limits. A final way out favours deregulation strategies which includes the introduction of environmental levies or the allocation of environmental licences. An interdisciplinary discourse is to find out what would happen if these ways were taken. Pointers to solutions from varying scientific disciplines resulting from this discourse are to be found in this volume. (orig./HSCH).

  17. Respect-Due and Respect-Earned: Negotiating Student-Teacher Relationships

    Science.gov (United States)

    Goodman, Joan F.

    2009-01-01

    Respect is a cardinal virtue in schools and foundational to our common ethical beliefs, yet its meaning is muddled. For philosophers Kant, Mill, and Rawls, whose influential theories span three centuries, respect includes appreciation of universal human dignity, equality, and autonomy. In their view children, possessors of human dignity, but…

  18. "We Want Respect": Adults with Intellectual and Developmental Disabilities Address Respect in Research

    Science.gov (United States)

    McDonald, Katherine Elizabeth

    2012-01-01

    Respect is central to ethical guidelines for research. The scientific community has long debated, and at times disagreed on, how to demonstrate respect in research with adults with intellectual and developmental disabilities. To illuminate the voices of those most affected, the author studies the views of adults with intellectual and developmental…

  19. Research as a Respectful Practice: An Exploration of the Practice of Respect in Qualitative Research

    Science.gov (United States)

    O'Grady, Emmanuel

    2016-01-01

    This article explores the practice of respect within qualitative research methods. As interpersonal respect plays a significant role in the esteem felt within a relationship, it can also serve to cultivate trust between researchers and their participants in a research study. This article details the findings of a research study examining respect…

  20. [How to promote the respect of good infusion practices by meeting health care professionals?].

    Science.gov (United States)

    Le Reste, C; Fiedler, A; Dubois, S; Dewailly, A; Le Du, I; Cogulet, V

    2016-05-01

    Health care professionals often forget that there are risks associated with infusion therapy even if it is a common care. In order to assess this practice and to draw potential improvement actions, an audit of local gravity-flow intravenous infusion practices was conducted. The audit, based on a grid including 66 items from the medical prescription to the end of the infusion therapy administration, was conducted in the 6 units which use the most gravity-flow intravenous infusion devices. A multidisciplinary working group was created to decide and organize priority corrective measures in order to improve infusion practices and quality of healthcare. The audit enabled to observe 90hours of nurse's practices (96 infusions) and highlighted heterogeneity in infusion, in some cases inappropriate infusion practices and misuse of infusion devices. We found 4 main issues: labelling infusion therapy, training of health care professionals on good practices, support the purchase of infusion pumps and standardize perfusion line. An interactive educational program for nurses (workshops) was organized to enhance the respect of good practices: infusion identification at any time, respect of hygiene rules, flow rate regulation by counting drops, appropriate use of pumps and flow rate regulators. The audit drew up work priorities. The workshops made easier exchanges between professionals and had a warm welcome that's why it is essential to carry on such training. This collaborative approach between pharmacists, nurses, hygienists and biomedical technicians contribute to drug management improvement and promote optimal patient care. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

  1. Medical Records and Correspondence Demand Respect

    Directory of Open Access Journals (Sweden)

    M Benamer

    2007-01-01

    Full Text Available To The Editor: I was amazed recently to see a patient from Libya who came to the UK for treatment based on the advice of his Libyan physicians. The patient carried with him no referral letter whatsoever. Not one physician familiar with his case bothered to write a few lines for the poor patient, although each of those doctors saw the patient at least twice and prescribed one or more treatment. The patient carried with him different medications that had been prescribed, and a few empty containers of other medicines he had used. I mention the above short tale to bring to light what I feel is a major ethical problem with the way medicine is practiced in Libya [1]. The keeping of good medical records together with clear and concise correspondence between physicians is imperative for several reasons. Not only does it avoid duplication of services and unnecessary costs, it decreases the time invested by both the patient and physician, and it fosters a collegial relationship among healthcare providers. Many times, referring physicians may not know each other. It provides a channel for them to learn from each other as well as a method for them to form professional relationships. It occurred to me that colleagues in Libya may be shy of writing referral letters or may even be phobic about disclosing their practice habits. Patient information can best be written as referral letters which summaries the patient presentation, testing, response to treatment, possible consultation, and reason for referral. The referral may be because the physician(s initially treating the patient simply have tried all treatments known to them, or they may need to refer if they lack certain diagnostic equipment necessary to continue the care. To refer the patient to colleagues simply says “we think more can be done for this patient but we may not be able to do it here; please evaluate.” It shows respect for the patient and for the colleague. No physician knows everything

  2. 26 CFR 302.1-2 - Application of regulations.

    Science.gov (United States)

    2010-04-01

    ... ADMINISTRATION TAXES UNDER THE INTERNATIONAL CLAIMS SETTLEMENT ACT, AS AMENDED AUGUST 9, 1955 § 302.1-2... (40 Stat. 411). (b) Taxes covered. The regulations in this part are applicable to any internal revenue tax with respect to (1) property vested in the Attorney General or any action or transaction...

  3. Terminology report respect distance. The Use of the term respect distance in Posiva and SKB

    International Nuclear Information System (INIS)

    Lampinen, H.

    2007-09-01

    The term respect distance is used in some key publications of the Finnish Nuclear Waste Management Company, Posiva, and the Swedish Nuclear Waste Management Company, SKB (Svensk Kaernbrenslehantering). Posiva and SKB researchers use the same terms in their reports, and it is acknowledged that the terms used by both companies are not used in the same way, though the differences are often subtle. This report is a literature study of the term 'respect distance' and the terms immediately associated to it. Vital terms related to the respect distance and issues concerning the use of scale concepts in Posiva and SKB are gathered in the end of report. Posiva's respect distances consider the seismic, hydrological and mechanical properties of the deterministic deformation zones as important issues that constitute a risk for longterm safety. These requirements for respect distances are an interpretation of STUK's YVL 8.4 Guide. At present, Posiva's criteria regarding respect distances follow the instructions given in the Host Rock Classification system (HRC), whereas the size of a deformation zone to which respect distances are applied vary from the regional to local major and minor. This and other criteria that are given for respect distances may, however, change in the near future as Posiva's Rock Suitability Criteria (RSC) programme proceeds. SKB's considerations of respect distances acknowledge that the hydraulic and mechanical aspects of a deformation zone have an effect on the respect distance. However, the seismic risk is considered to overshadow the other effects on a regional scale. The respect distance defined for a deformation zone is coupled with the size of a fracture where secondary slip could occur. In the safety assessment it is assumed that this fracture cuts a deposition hole location. In SKB the respect distance is determined for regional and local major deformation zones. The trace length of such a zone is defined as being ≥ 3 km. For deformation zones

  4. [Human values and respect of human rights in oppressive conditions].

    Science.gov (United States)

    Bomba, J

    1993-01-01

    Human rights, an issue of political debates in the last decades, listed in the United Nations Declaration of 1946 are rooted in the humanistic tradition of philosophy and religion. The UN declared their universal character and made state organizations responsible for their observation. Among all human rights that for freedom is usually perceived as crucial. Psychiatry developed in Europe primarily a caring function. The medical model developed in psychiatry through the 19th c. supplied the criteria for medical diagnosis of mental disturbance, and elaborated a system of treatment which included long term hospitalization. Medicalization of psychiatry (recently coming back) is a force which gives courage to those who suffer, to their families, and to professionals as well. This power however, can be easily abused, when a psychiatrist adopts a position of someone who knows better that which is good for his/her patient. Legal regulations of the circumstances of psychiatric treatment, especially treatment against the patient's will should prevent the abuse of the mentally disturbed person's right for freedom. The goal is usually achieved by clear description of clinical and other conditions under which a person can be committed, and by establishing the committed person's right to claim the decision to be unjust. Poland is a country without legal regulation in the area of mental health (there are only administrative acts). For more than sixty years several projects on mental health law have been worked on. The last one which came to the Sejm (parliament) in 1980 was withdrawn by the "Solidarity" Trade Union. At present, the membership of Poland in international organizations makes an introduction of mental health law an obligation. Having no legal regulation, Polish psychiatry has been a self-regulating system. It is worth to note that even in the hard Stalinist period (1947-1956) there was no abuse of psychiatry for political reasons. The main reason for Polish

  5. Administrative Appeals and ADR in Danish Administrative Law

    DEFF Research Database (Denmark)

    Conradsen, Inger Marie; Gøtze, Michael

    2014-01-01

    Administrative Appeals, review, administrative tribunals, ombudsman, alternative dispute resolution......Administrative Appeals, review, administrative tribunals, ombudsman, alternative dispute resolution...

  6. 10 CFR 725.24 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Administration. 725.24 Section 725.24 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.24 Administration. With respect to each permit... designate a DOE or National Nuclear Security Administration office which will: (a) Process all personnel...

  7. Transcultural perspectives in nursing administration.

    Science.gov (United States)

    Andrews, M M

    1998-11-01

    Population demographics are reshaping the healthcare work force with respect to race, ethnicity, gender, national origin, sexual orientation, age, handicap, disability, and related factors as national sensitivity to various forms of diversity grows. Given the demographic trends, it is inevitable that nurse administrators will need skill in transcultural administration as they manage diversity and identify the cultural origins of conflict in the multicultural workplace. Culture influences the manner in which administrators, staff and patients perceive, identify, define and solve problems. In this article, the complex and interrelated factors that influence workplace diversity are examined.

  8. 7. Administrative structures.

    Science.gov (United States)

    2014-05-01

    The basic systems of any society rarely can operate independently. Instead, they are dependent and often interdependent upon other entities. Such entities control the resources within their respective systems. Thus, coordination and control agencies require contracts or memoranda of understanding with these entities in order to assure access to the resources required during a crisis. These administrative structures include: (1) governmental institutions and agencies, including the military; (2) intergovernmental organisations; (3) nongovernmental organisations; (4) commercial private sector organisations; and (5) academic institutions. These dependencies create potential barriers to the provision of coordination and control including: (1) the complexity of the administrative structures with which coordination and control must interact; (2) the location of resources; (3) finding responsible person(s); (4) the competence and compatibility; (5) methods of access; (6) payment; (7) contracts and memoranda of understanding; (8) inventories of accessible resources; (9) competition for the mandate, power, and resources; and (10) jealousy. The need for potential interactions between administrative structures requires that agreements for the sharing of resources during crises be reached as part of planning and preparedness. Gaining an understanding of these relationships is an important area for research.

  9. Decision-making in administrative proceeding

    Directory of Open Access Journals (Sweden)

    Lončar Zoran J.

    2015-01-01

    Full Text Available Administrative decision-making by official who conducting the administrative procedure may have a number of advantages over the decisionmaking by the senior official which manages by the administrative authority. However, to make that such a novelty have positive effects, it is necessary, next to the amendments to the Law on Administrative Procedure, to create a number of legal and factual assumptions, on whom are based highly politicized and professionalised administrative systems today. In order to create the legal conditions for the introduction of innovations in administrative proceedings in the Republic of Serbia, it is necessary to appropriately modify, firstly certain provisions of the Law on Public Administration, as the basic systemic regulation in this area, and then the Law on Civil Servants, as the basic status regulation, so the civil servant career become less dependent on the will of officials who manage by the administrative authorities. Also, it is essential to solve a number of other issues on a proper legal way, such as way of harmonizing administrative practice within the same administrative authority, a way of solving the appeals in the case of first instance decisions made by independent administrative authority, different rules for conflict of interest with the state officers who may be authorized officials in administrative proceedings, etc.

  10. "Children are from heaven" or how today children respect adults

    Directory of Open Access Journals (Sweden)

    Barbara Vogrinec

    2007-06-01

    Full Text Available The starting point of the text is a returning to the patriarchal, which is not simply the one that we are witnessing today, in the time of so-called postmodern, postpatriarchal society in its (until now last form. It is a matter of returning to rules, of which the basic premise is that adults are subjects (transcendences, freedoms, activities and children are subjects that are objects for adults (imanences, non-freedoms, pasivities, but which notwithstanding differ from the oldfashioned rules from the past. We attempted to explain this returning, following the example of rules offered by the book Children Are From Heaven – a selfhelp book, published at the end of the nineties of the 20th century, which immediately became the world's bestseller. In addition, our aim was to answer the following questions: What has happened with rules of civilization and good manners, regulating the relations between children and adults today? How have they changed and what has happened with children's or adults's relation to these rules or their performings? How has this relation changed? Considering the mentioned basic premise which implies that children respect adults, we also tried to answer the question: What has happened with the respect, or, how do children respect adults today? Disscussion is presented in the framework of lacanian psychoanalysis.

  11. Ombuds’ corner: Is our respectful workplace strategy working?

    CERN Multimedia

    Vincent Vuillemin

    2012-01-01

    “I hope that the Code of Conduct will be a valuable tool in the maintenance and development of a workplace marked by mutual respect and understanding. We should familiarize ourselves with it, and incorporate it into our daily life at CERN.”*   “The Organization does not tolerate harassment, which can result in administrative and/or disciplinary action.”** Our Code of Conduct (“the Code”) sets the basic standards of ethical behaviour that we must first all set for ourselves. In addition, we are also entitled to expect our workplace colleagues to respect these standards. In biblical terms, if I may, the Code is an incentive for us to notice the beam obstructing our eyes and not focus on the speck in the eyes of our colleagues. In short, we should first look to ourselves to apply the Code. Managers, whatever their position, should be accountable for their team being aware of the Code and are acting according to its values - just as they...

  12. Flexibility of the genetic code with respect to DNA structure

    DEFF Research Database (Denmark)

    Baisnée, P. F.; Baldi, Pierre; Brunak, Søren

    2001-01-01

    Motivation. The primary function of DNA is to carry genetic information through the genetic code. DNA, however, contains a variety of other signals related, for instance, to reading frame, codon bias, pairwise codon bias, splice sites and transcription regulation, nucleosome positioning and DNA...... structure. Here we study the relationship between the genetic code and DNA structure and address two questions. First, to which degree does the degeneracy of the genetic code and the acceptable amino acid substitution patterns allow for the superimposition of DNA structural signals to protein coding...... sequences? Second, is the origin or evolution of the genetic code likely to have been constrained by DNA structure? Results. We develop an index for code flexibility with respect to DNA structure. Using five different di- or tri-nucleotide models of sequence-dependent DNA structure, we show...

  13. Everywhere divergent Fourier series with respect to the Walsh system and with respect to multiplicative systems

    International Nuclear Information System (INIS)

    Bochkarev, S V

    2004-01-01

    In this paper a new construction of everywhere divergent Fourier-Walsh series is presented. This construction enables one to halve the gap in the Lebesgue-Orlicz classes between the Schipp-Moon lower bound established by using Kolmogorov's construction and the Sjoelin upper bound obtained by using Carleson's method. Fourier series which are everywhere divergent after a rearrangement are constructed with respect to the Walsh system (and to more general systems of characters) with the best lower bound for the Weyl factor. Some results related to an upper bound of the majorant for partial sums of series with respect to rearranged multiplicative systems are established. The results thus obtained show certain merits of harmonic analysis on the dyadic group in clarifying and overcoming fundamental difficulties in the solution of the main problems of Fourier analysis

  14. The Scope of the Obligation to Respect and to Ensure Respect for International Humanitarian Law

    Directory of Open Access Journals (Sweden)

    Tomasz Zych

    2009-10-01

    Full Text Available This article disputes what seems to have become the dominant interpretation of the obligation to respect and to ensure respect for International Humanitarian Law, as codified in common Article 1 of the Geneva Conventions and in Article 1(1 of Additional Protocol I. According to this dominant interpretation, States are required to take all appropriate measures to ensure that IHL is observed universally, including by other States and by non-State actors operating in other States. It is argued that the intention of the High Contracting Parties, coupled with their subsequent practice, calls for a much more narrow interpretation of that obligation. Cet article conteste ce qui semble être devenue l’interprétation dominante de l’obligation de respecter et de faire respecter le Droit International Humanitaire, tel que codifiée à l’article 1 commun aux Conventions de Genève et à l’article 1(1 du Protocole additionnel I. Selon cette interprétation dominante, les États doivent prendre toutes les mesures appropriées pour assurer que le DIH soit observé de façon universelle, y compris par d’autres États ainsi que par des acteurs non étatiques qui opèrent à l’intérieur d’autres États. On soutient que l’intention des Hautes Parties contractantes, en conjonction avec leur pratique subséquentes, laisse entendre une interprétation beaucoup plus étroite de cette obligation.

  15. 49 CFR 386.54 - Administrative Law Judge.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Administrative Law Judge. 386.54 Section 386.54... General Rules and Hearings § 386.54 Administrative Law Judge. (a) Powers of an Administrative Law Judge. The Administrative Law Judge may take any action and may prescribe all necessary rules and regulations...

  16. 32 CFR 1602.2 - Administrative classification.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Administrative classification. 1602.2 Section 1602.2 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.2 Administrative classification. A reclassification action relating to a registrant's claim...

  17. 7 CFR 1412.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1412.2 Section 1412.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... REVENUE ELECTION PROGRAM FOR THE 2008 AND SUBSEQUENT CROP YEARS General Provisions § 1412.2 Administration...

  18. 7 CFR 792.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 792.2 Section 792.2 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE PROVISIONS COMMON TO MORE THAN ONE PROGRAM DEBT SETTLEMENT POLICIES AND PROCEDURES § 792.2 Administration...

  19. 7 CFR 252.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 252.3 Section 252.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Administration. (a) Role of FNS. The Secretary will designate those commodities which will be available under the...

  20. 7 CFR 1466.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1466.2 Section 1466.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... § 1466.2 Administration. (a) The funds, facilities, and authorities of the Commodity Credit Corporation...

  1. 7 CFR 1430.501 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1430.501 Section 1430.501 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF....501 Administration. (a) The provisions of §§ 1430.351, 1430.352, 1430.354, 1430.355, and 1430.360...

  2. 7 CFR 1424.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1424.2 Section 1424.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOENERGY PROGRAM § 1424.2 Administration. This part shall...

  3. 7 CFR 782.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 782.3 Section 782.3 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS END-USE CERTIFICATE PROGRAM General § 782.3 Administration. The end-use certificate...

  4. 7 CFR 27.100 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Administration. 27.100 Section 27.100 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Administration. The details of the method of carrying out the provisions of this subpart in each bona fide spot...

  5. 7 CFR 1435.4 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1435.4 Section 1435.4 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM General Provisions § 1435.4 Administration...

  6. 7 CFR 1423.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1423.2 Section 1423.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. On behalf of CCC, the Farm Service Agency (FSA) will administer this part under the supervision...

  7. 7 CFR 783.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 783.2 Section 783.2 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS TREE ASSISTANCE PROGRAM § 783.2 Administration. (a) The program will be administered...

  8. 75 FR 61552 - Federal Railroad Administration

    Science.gov (United States)

    2010-10-05

    ... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Notice of Informational Filing In accordance with Section 236.913 of Title 49 of the Code of Federal Regulations (CFR), notice is hereby given that the Federal Railroad Administration (FRA) has received an informational filing from the Northeast...

  9. 7 CFR 701.1 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 701.1 Section 701.1 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... ADMINISTERED UNDER THIS PART § 701.1 Administration. (a) Subject to the availability of funds, this part...

  10. 7 CFR 760.900 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 760.900 Section 760.900 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Livestock Indemnity Program § 760.900 Administration...

  11. 7 CFR 760.1200 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 760.1200 Section 760.1200 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Catfish Grant Program § 760.1200 Administration. FSA...

  12. 7 CFR 636.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 636.2 Section 636.2 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVES PROGRAM § 636.2 Administration. (a) The...

  13. 7 CFR 760.1 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 760.1 Section 760.1 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. This indemnity payment program will be carried out by FSA under the direction and supervision of...

  14. 7 CFR 81.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 81.2 Section 81.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... PROGRAMS PRUNE/DRIED PLUM DIVERSION PROGRAM § 81.2 Administration. The program will be administered under...

  15. 7 CFR 1421.301 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1421.301 Section 1421.301 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... 2012 Crop of Wheat, Barley, Oats, and Triticale § 1421.301 Administration. (a) This subpart shall be...

  16. 7 CFR 784.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 784.2 Section 784.2 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS 2004 EWE LAMB REPLACEMENT AND RETENTION PAYMENT PROGRAM § 784.2 Administration. (a) This...

  17. 7 CFR 1421.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1421.2 Section 1421.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 General § 1421.2 Administration. (a) The...

  18. 7 CFR 20.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 20.2 Section 20.2 Agriculture Office of the Secretary of Agriculture EXPORT SALES REPORTING REQUIREMENTS § 20.2 Administration. The regulations of this part will be administered by the Foreign Agricultural Service (FAS) under the general...

  19. 7 CFR 786.101 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 786.101 Section 786.101 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DAIRY DISASTER ASSISTANCE PAYMENT PROGRAM (DDAP-III) § 786.101 Administration. (a) DDAP...

  20. 7 CFR 82.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 82.2 Section 82.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... PROGRAMS CLINGSTONE PEACH DIVERSION PROGRAM § 82.2 Administration. The program will be administered under...

  1. 7 CFR 1427.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1427.2 Section 1427.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... § 1427.2 Administration. (a) The marketing assistance loan and loan deficiency payment programs shall be...

  2. 7 CFR 1427.161 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1427.161 Section 1427.161 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COTTON Recourse Seed Cotton Loans § 1427.161 Administration...

  3. 7 CFR 1430.601 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1430.601 Section 1430.601 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Program II (DDAP-II) § 1430.601 Administration. (a) DDAP-II shall be administered under the general...

  4. 7 CFR 1430.301 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1430.301 Section 1430.301 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Program § 1430.301 Administration. (a) The 2004 Dairy Disaster Assistance Payment Program shall be...

  5. 7 CFR 760.801 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 760.801 Section 760.801 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760.801 Administration. (a...

  6. 7 CFR 1430.201 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1430.201 Section 1430.201 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) This program is administered under the general supervision of the Executive Vice President...

  7. 7 CFR 7.1 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 7.1 Section 7.1 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.1 Administration. (a) The regulations of this part are...

  8. 7 CFR 1412.71 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1412.71 Section 1412.71 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF...) Program § 1412.71 Administration. (a) All of the provisions of this part apply to this subpart. To the...

  9. 7 CFR 1425.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1425.2 Section 1425.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.2 Administration...

  10. 7 CFR 1416.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1416.3 Section 1416.3 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... General Provisions for 2006 Emergency Agricultural Disaster Assistance Programs § 1416.3 Administration...

  11. 24 CFR 3285.1 - Administration.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Administration. 3285.1 Section 3285.1 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS General § 3285.1 Administration. (a) Scope. These...

  12. 7 CFR 1410.1 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1410.1 Section 1410.1 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION RESERVE PROGRAM § 1410.1 Administration. (a...

  13. 7 CFR 1463.101 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1463.101 Section 1463.101 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Payment Program § 1463.101 Administration. (a) The program will be administered under the general...

  14. 7 CFR 1463.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1463.2 Section 1463.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Assessments § 1463.2 Administration. The provisions of this subpart will be administered under the general...

  15. 7 CFR 1468.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1468.2 Section 1468.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) CFO is carried out using Commodity Credit Corporation funds and will be administered on...

  16. 7 CFR 1437.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1437.2 Section 1437.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Provisions § 1437.2 Administration. (a) NAP is administered under the general supervision of the Executive...

  17. 7 CFR 1436.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1436.2 Section 1436.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) The Farm Storage Facility Loan Program will be administered under the general supervision of...

  18. 7 CFR 1580.501 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1580.501 Section 1580.501 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF AGRICULTURE TRADE ADJUSTMENT ASSISTANCE FOR FARMERS § 1580.501 Administration. (a) The application process...

  19. 7 CFR 550.33 - Administrative supervision.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administrative supervision. 550.33 Section 550.33 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS Management of Agreements Program Management § 550.33...

  20. 15 CFR 990.45 - Administrative record.

    Science.gov (United States)

    2010-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION ACT REGULATIONS... opened concurrently with the publication of the Notice of Intent to Conduct Restoration Planning. Depending on the nature and extent of the incident and assessment, the administrative record should include...

  1. 29 CFR 4901.17 - Exhaustion of administrative remedies.

    Science.gov (United States)

    2010-07-01

    ... (including any extension) for making such determination or decision, the requester's administrative remedies....17 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION INTERNAL AND ADMINISTRATIVE RULES AND PROCEDURES EXAMINATION AND COPYING OF PENSION BENEFIT GUARANTY CORPORATION RECORDS...

  2. 22 CFR 139.4 - Responsibilities of the Program Administrator.

    Science.gov (United States)

    2010-04-01

    ... of living, support infrastructure, and other relevant factors. The Program Administrator, from time... program regulations, including rules of the Program Administrator and the code of code of conduct; or the...

  3. Then years of nuclear safety in France: administrative action

    International Nuclear Information System (INIS)

    Torquat, C. de; Levy, M.

    1983-01-01

    General principles of administrative action concerning nuclear safety in France are recalled. The three principal and complementary aspects of the action are described: technical regulations; administrative procedures; inspection of plant being constructed or already in operation [fr

  4. Administrative Data Repository (ADR)

    Data.gov (United States)

    Department of Veterans Affairs — The Administrative Data Repository (ADR) was established to provide support for the administrative data elements relative to multiple categories of a person entity...

  5. EPA Administrative Enforcement Dockets

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Administrative Enforcement Dockets database contains the electronic dockets for administrative penalty cases filed by EPA Regions and Headquarters. Visitors...

  6. Philippines - Revenue Administration Reform

    Data.gov (United States)

    Millennium Challenge Corporation — The Millennium Challenge Account-Philippines' (MCA-P) implementation of the Revenue Administration Reform Project (RARP) is expected to improve tax administration,...

  7. Respect for nursing professional: Silence must be heard

    Directory of Open Access Journals (Sweden)

    Sundeep Mishra

    2015-09-01

    Full Text Available The value of care giving seems to be at an all-time low. whether it is clinical (bedside or for children and elderly at home (homemakers. Currently, individuals who pass away any opportunity (for themselves to care for another individual instead are considered weak and/or unmotivated. Thus, it is not surprising that modern society often fails to respect the nursing professionals to the extent of underplaying their strengths, skills, and even clinical abilities. While qualities such as kindness, team spirit, and willingness to get their hands dirty are the core of this profession, nursing professionals have a complex variety of set duties, involving drug dosage, trouble-shooting, ongoing patient monitoring, and providing holistic comfort and support to the sick and needy. Beyond classical role, the nursing professional has currently ventured into other roles as well, as a nurse practitioner, administrator, researcher, or even an educator. Thus, considering the wide spectrum of duties performed by nursing professionals, they do deserve more status and power rather than be treated like “ward housewives.”

  8. The administrative contract asimilated to administrative acts in administrative litigation

    Directory of Open Access Journals (Sweden)

    Silvia GORIUC

    2018-03-01

    Full Text Available An administrative contract is the will between a public authority either a person empowe¬red by it, and one or more natural or legal persons, whether private or public, pursuing the realization of a public interest and to which a special scheme of administrative law applies. The typology of administrative contracts is very varied, depending on the evolution of the society’s needs. Thus, they are currently included in the category of administrative contracts: concession contracts and public procurement contracts, contracts for the use of public goods, public management contracts, public-private partnership contracts, public lending contracts and constitutive documents of the associative structures of public authorities.

  9. FRACTAL PROPERTY OF ADMINISTRATION

    OpenAIRE

    Zlatko Brnjas

    2014-01-01

    To understand the constant increase in administration, we need a new approach to the administration. For many years, the administration has intensified as a closed science, associated only with economics, law and political science. However, this approach did not bring anything good, because almost nothing in the administration has improved. Therefore, it is necessary to connect the administration with the natural sciences which give the best description of the world around us. Because of this...

  10. Case of administrative dispute

    Directory of Open Access Journals (Sweden)

    Xhemazie Ibraimi

    2015-11-01

    Full Text Available The activity of administrative bodies includes big numbers of various acts and actions, through which the will of public administration is formed. The will of public administration bodies, expressed in administrative individual and normative acts, in administrative contracts and real acts, finds its reflection in the Constitution, laws and other provisions of legal character. All this activity is not inerrant and therefore, it is not uncontrollable. The supervision of executive activity is subject to political control of administrative acts through authorities designated for this purpose, as well as internal control and the judicial control. The institution of judicial control of administrative acts and actions appears as very important and widely treated in the legal doctrine. The protection of constitutional and legal rights of private persons is accomplished by subjecting administrative activity both to internal administrative control, as well as to the judicial control in accordance with legal provisions. The judicial control of administrative acts represents a constitutional guarantee for citizens to protect their rights through public and fair trial by an independent and impartial court. In this way, the Constitution empowers the common administrative court that invalidates an action or administrative act, but not all administrative acts may be subject to administrative dispute, with the exception of cases against which the administrative conflict cannot be carried out (negative enumeration.

  11. Administration in an operating plant

    International Nuclear Information System (INIS)

    Staebler, K.

    1977-01-01

    The importance of strict administrative procedures in the daily work is being demonstrated by commenting on events that occured in the operation of German nuclear power plants. The procedure for working in an area of the plant (pressurized medium, high-radioactive level, explosive of flammable mediums), where special measures for safe working have to be taken, is discussed in detail. The administrative problems during refuelling time are further on mentioned, especially the problems connected with administering more than 1,000 people with respect to health protection and sabotage protection. Some general comments on the influences from external causes (authorities, courts, etc.) are given. (orig./ORU) [de

  12. Behavioral Public Administration

    DEFF Research Database (Denmark)

    Grimmelikhuijsen, Stephan; Jilke, Sebastian; Olsen, Asmus Leth

    2017-01-01

    on theories and methods from psychology and related fields and point to research in public administration that could benefit from further integration. An analysis of public administration topics through a psychological lens can be useful to confirm, add nuance to, or extend classical public administration...... theories. As such, behavioral public administration complements traditional public administration. Furthermore, it could be a two-way street for psychologists who want to test the external validity of their theories in a political-administrative setting. Finally, four principles are proposed to narrow......Behavioral public administration is the analysis of public administration from the micro-level perspective of individual behavior and attitudes by drawing on insights from psychology on the behavior of individuals and groups. The authors discuss how scholars in public administration currently draw...

  13. 5 CFR 179.301 - Scope of regulations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Scope of regulations. 179.301 Section 179.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Administrative Offset § 179.301 Scope of regulations. These regulations apply to the...

  14. Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after Administration.

    Directory of Open Access Journals (Sweden)

    Nils Rudqvist

    Full Text Available 211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. However, a limitation has been the preferential accumulation of released 211At in the thyroid gland, which is a critical organ for such therapy. The aim of this study was to determine the effect of absorbed dose, dose-rate, and time after 211At exposure on genome-wide transcriptional expression in mouse thyroid gland.BALB/c mice were i.v. injected with 1.7, 7.5 or 100 kBq 211At. Animals injected with 1.7 kBq were killed after 1, 6, or 168 h with mean thyroid absorbed doses of 0.023, 0.32, and 1.8 Gy, respectively. Animals injected with 7.5 and 100 kBq were killed after 6 and 1 h, respectively; mean thyroid absorbed dose was 1.4 Gy. Total RNA was extracted from pooled thyroids and the Illumina RNA microarray platform was used to determine mRNA levels. Differentially expressed transcripts and enriched GO terms were determined with adjusted p-value 1.5, and p-value <0.05, respectively.In total, 1232 differentially expressed transcripts were detected after 211At administration, demonstrating a profound effect on gene regulation. The number of regulated transcripts increased with higher initial dose-rate/absorbed dose at 1 or 6 h. However, the number of regulated transcripts decreased with mean absorbed dose/time after 1.7 kBq 211At administration. Furthermore, similar regulation profiles were seen for groups administered 1.7 kBq. Interestingly, few previously proposed radiation responsive genes were detected in the present study. Regulation of immunological processes were prevalent at 1, 6, and 168 h after 1.7 kBq administration (0.023, 0.32, 1.8 Gy.

  15. ADMINISTRATIVE CONTRACTS. DELIMITATIONS

    Directory of Open Access Journals (Sweden)

    Liana Teodora PASCARIU

    2016-12-01

    Full Text Available Article examines whether all contracts of public persons are administrative contracts; in other words, if the administration may conclude contracts that, according to their legal nature, are not administrative. If we start from the definition of administrative contracts as it appears in Law no. 554/2004, these include contracts by public authorities which concern the enhancement of public property execution of works of public interest, public services, public procurement and other administrative contracts provided by special laws and subject to the jurisdiction of the administrative courts.

  16. Radiation recommendation series: administratively required dental radiographs

    International Nuclear Information System (INIS)

    1981-09-01

    Administrative requirements for radiographs are found in many segments of the United States health care system. This document presents an FDA radiation recommendation on administratively required dental x-ray examinations. In general, such examinations are not requested to further the patient's dental health, but rather as a means of monitoring claims. However, the administrative use of radiographs that have been taken in the normal course of patient care is usually appropriate, as long as the patient's right to privacy is respected

  17. Administration of Anesthesia

    Medline Plus

    Full Text Available ... OMSs) are trained in all aspects of anesthesia administration. Following dental school, they complete at least four ... complications and emergencies that may arise during the administration of anesthesia. Before your surgery, your OMS will ...

  18. Administration of Anesthesia

    Science.gov (United States)

    ... OMSs) are trained in all aspects of anesthesia administration. Following dental school, they complete at least four ... complications and emergencies that may arise during the administration of anesthesia. Before your surgery, your OMS will ...

  19. Drug Enforcement Administration

    Science.gov (United States)

    ... de informacin confidencial --> DEA NEWS The Drug Enforcement Administration and Discovery Education name grand winner of Operation ... JUN 15 (Washington) The United States Drug Enforcement Administration, DEA Educational Foundation and Discovery Education awarded Porter ...

  20. 4 CFR 28.22 - Administrative judges.

    Science.gov (United States)

    2010-01-01

    .... Administrative judges shall conduct fair and impartial hearings and take all necessary action to avoid delay in...; (8) Require the filing of memoranda of law and the presentation of oral argument with respect to any...

  1. 48 CFR 822.406 - Administration and enforcement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration and enforcement. 822.406 Section 822.406 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Involving Construction 822.406 Administration and enforcement. ...

  2. 32 CFR 22.715 - Grants administration office functions.

    Science.gov (United States)

    2010-07-01

    ... ensure that recipients fulfill all requirements in law, regulation, and award terms and conditions... Governments, and Non-Profit Organizations.” 14 13 Electronic copies may be obtained at the Washington... AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION Field Administration § 22.715...

  3. 48 CFR 2901.603-72 - Administrative procurement management reviews.

    Science.gov (United States)

    2010-10-01

    ... Authority, and Responsibilities 2901.603-72 Administrative procurement management reviews. (a) The Senior... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administrative procurement management reviews. 2901.603-72 Section 2901.603-72 Federal Acquisition Regulations System DEPARTMENT OF...

  4. Cloudera administration handbook

    CERN Document Server

    Menon, Rohit

    2014-01-01

    An easy-to-follow Apache Hadoop administrator's guide filled with practical screenshots and explanations for each step and configuration. This book is great for administrators interested in setting up and managing a large Hadoop cluster. If you are an administrator, or want to be an administrator, and you are ready to build and maintain a production-level cluster running CDH5, then this book is for you.

  5. NASA, NOAA administrators nominated

    Science.gov (United States)

    Richman, Barbara T.

    President Ronald Reagan recently said he intended to nominate James Montgomery Beggs as NASA Administrator and John V. Byrne as NOAA Administrator. These two positions are key scientific posts that have been vacant since the start of the Reagan administration on January 20. The President also said he intends to nominate Hans Mark as NASA Deputy Administrator. At press time, Reagan had not designated his nominee for the director of the Office of Science and Technology Policy.

  6. 13 CFR 120.1712 - Seller responsibilities with respect to Seller's Pool Loan.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Seller responsibilities with respect to Seller's Pool Loan. 120.1712 Section 120.1712 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504...

  7. 29 CFR 580.15 - Responsibility of the Office of Administrative Law Judges for the administrative record.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Responsibility of the Office of Administrative Law Judges for the administrative record. 580.15 Section 580.15 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CIVIL MONEY PENALTIES-PROCEDURES FOR ASSESSING AND CONTESTING PENALTIES Referral for Hearing ...

  8. 48 CFR 3410.701 - Policy of the Department of Education with respect to use of the metric system.

    Science.gov (United States)

    2010-10-01

    ... of Education with respect to use of the metric system. 3410.701 Section 3410.701 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION COMPETITION AND ACQUISITION PLANNING... of Education with respect to use of the metric system. It is the policy of the Department of...

  9. 48 CFR 3410.703 - Responsibilities of the Department of Education with respect to use of the metric system.

    Science.gov (United States)

    2010-10-01

    ... Department of Education with respect to use of the metric system. 3410.703 Section 3410.703 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION COMPETITION AND ACQUISITION... Responsibilities of the Department of Education with respect to use of the metric system. (a) Consistent with the...

  10. 7 CFR 1000.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... Federal milk order each handler shall pay to the market administrator its pro rata share of the expense of administration of the order at a rate specified by the market administrator that is no more than 5 cents per... disposition in the marketing area from a partially regulated distributing plant that exceeds the skim milk and...

  11. Effective environmental protection by the reform of the administrative procedures and administrative legal rights

    International Nuclear Information System (INIS)

    Breuer, R.

    1978-01-01

    The 52nd German Lawyers Meeting will be concerned in its legal department with the question of whether, from the points of view of the guaranteeing of the necessary environmental protection, additional regulations in the administrative procedures and administrative legal rights should be recommended. Here one is concerned, above all, with the problem of whether an administrative legal associations sueing or associations participation in administrative legal procedures is desirable in the interests of environmental protection. A negative answer must be given to this question. Discussion should concentrate on the problematical administrative legal interests, on the strengthening of administrative participation of popular opinion or interests in legal processes, on other improvements in administrative processes and on the legal control by Parliament of environmental protection. (orig.) [de

  12. Environmental impacts of fracking in the exploration and production of natural gas from unconventional deposits. Risk assessment, recommendations for action and evaluation of existing legal regulations and administrative structures; Umweltauswirkungen von Fracking bei der Aufsuchung und Gewinnung von Erdgas aus unkonventionellen Lagerstaetten. Risikobewertung, Handlungsempfehlungen und Evaluierung bestehender rechtlicher Regelungen und Verwaltungsstrukturen

    Energy Technology Data Exchange (ETDEWEB)

    Meiners, Georg; Denneborg, Michael; Mueller, Frank [ahu AG Wasser - Boden - Geomatik, Aachen (Germany); Bergmann, Axel; Weber, Frank-Andreas; Dopp, Elke; Hansen, Carsten; Schueth, Christoph [IWW Rheinisch-Westfaelisches Institut fuer Wasser - Beratungs- und Entwicklungsgesellschaft mbH, Muelheim an der Ruhr (Germany)

    2012-08-15

    We examine the water-related environmental impacts and the risks for human health and the environment that could potentially be caused by hydraulic fracturing (fracking) during exploration and exploitation of unconventional natural gas reservoirs in Germany. This study covers both scientific-technical aspects and the existing mining and environmental regulations. Both were analyzed with respect to consistency, differences and current gaps of knowledge and lack of relevant information. After a general introduction, this study is divided into four sections: We first focus on the description of geospatial conditions, technical aspects and the chemical additives employed by hydraulic fracturing (Part A) and the existing regulatory and administrative framework (Part B), before we conduct a risk and deficit analysis (Part C) and derive recommendations for further actions and proceedings (Part D). The foundation of a sound risk analysis is a description of the current system, the relevant effect pathways and their interactions. We describe known and assumed unconventional natural gas reservoirs in Germany based on publicly available information. We present qualitatively the relevant system interactions for selected geosystems and assess potential technical and geological effect pathways. With regard to the technical aspects, we describe the principles of rock mechanics and provide an overview of the technical fracturing process. In terms of groundwater protection, the key focus is on borehole completion, modelling of fracture propagation and the longterm stability of the borehole (incl. cementation). The injected fracturing fluids contain proppants and several additional chemical additives. The evaluation of fracturing fluids used to date in Germany shows that even in newer fluids several additives were used which exhibit critical properties and/or for which an assessment of their behaviour and effects in the environment is not possible or limited due to lack of the

  13. Environmental impacts of fracking in the exploration and production of natural gas from unconventional deposits. Risk assessment, recommendations for action and evaluation of existing legal regulations and administrative structures; Umweltauswirkungen von Fracking bei der Aufsuchung und Gewinnung von Erdgas aus unkonventionellen Lagerstaetten. Risikobewertung, Handlungsempfehlungen und Evaluierung bestehender rechtlicher Regelungen und Verwaltungsstrukturen

    Energy Technology Data Exchange (ETDEWEB)

    Meiners, Georg; Denneborg, Michael; Mueller, Frank [ahu AG Wasser - Boden - Geomatik, Aachen (Germany); Bergmann, Axel; Weber, Frank-Andreas; Dopp, Elke; Hansen, Carsten; Schueth, Christoph [IWW Rheinisch-Westfaelisches Institut fuer Wasser - Beratungs- und Entwicklungsgesellschaft mbH, Muelheim an der Ruhr (Germany)

    2012-08-15

    We examine the water-related environmental impacts and the risks for human health and the environment that could potentially be caused by hydraulic fracturing (fracking) during exploration and exploitation of unconventional natural gas reservoirs in Germany. This study covers both scientific-technical aspects and the existing mining and environmental regulations. Both were analyzed with respect to consistency, differences and current gaps of knowledge and lack of relevant information. After a general introduction, this study is divided into four sections: We first focus on the description of geospatial conditions, technical aspects and the chemical additives employed by hydraulic fracturing (Part A) and the existing regulatory and administrative framework (Part B), before we conduct a risk and deficit analysis (Part C) and derive recommendations for further actions and proceedings (Part D). The foundation of a sound risk analysis is a description of the current system, the relevant effect pathways and their interactions. We describe known and assumed unconventional natural gas reservoirs in Germany based on publicly available information. We present qualitatively the relevant system interactions for selected geosystems and assess potential technical and geological effect pathways. With regard to the technical aspects, we describe the principles of rock mechanics and provide an overview of the technical fracturing process. In terms of groundwater protection, the key focus is on borehole completion, modelling of fracture propagation and the longterm stability of the borehole (incl. cementation). The injected fracturing fluids contain proppants and several additional chemical additives. The evaluation of fracturing fluids used to date in Germany shows that even in newer fluids several additives were used which exhibit critical properties and/or for which an assessment of their behaviour and effects in the environment is not possible or limited due to lack of the

  14. 50 CFR 216.86 - Local regulations.

    Science.gov (United States)

    2010-10-01

    ... Pribilof Islands Administration § 216.86 Local regulations. Local regulations will be published from time... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Local regulations. 216.86 Section 216.86 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

  15. A Qualitative Study of Vape Shop Operators' Perceptions of Risks and Benefits of E-Cigarette Use and Attitude Toward Their Potential Regulation by the US Food and Drug Administration, Florida, Georgia, South Carolina, or North Carolina, 2015.

    Science.gov (United States)

    Nayak, Pratibha; Kemp, Catherine B; Redmon, Pamela

    2016-05-19

    Approximately 8,500 vape shops in the United States sell a variety of electronic nicotine delivery systems (ENDS). This study examined vape shop operators' perceptions of benefits and risk of ENDS use, what they perceive to be the reasons for ENDS use, their source of product information, what information they shared with customers, and the impact of existing and future regulation of ENDS on its use and on their business. We conducted qualitative interviews with 20 vape shop operators located in Florida, Georgia, South Carolina, and North Carolina in spring 2015. A semi-structured interview guide was used, and interviews were audio-recorded and transcribed verbatim. The transcripts were analyzed using NVIVO software. Vape shop owners perceived ENDS to be less harmful and more economical than conventional cigarettes and indicated that most of their customers used ENDS as a smoking cessation tool. Most owners were former smokers and used ENDS to quit. Shop owners relied on their personal experiences and the Internet for information, and shared information with customers at point of sale by using the shop's website and social media. Most expressed concern that complying with potential regulations, including banning flavors or tax increases, would jeopardize their business. Some felt that ENDS should not be regulated as tobacco products and felt that big tobacco was behind these proposed regulations. Most owners supported age restrictions and quality controls for e-liquid. Vape shop owners are in a unique position to serve as frontline consumer educators. Interventions should focus on providing them with current information on benefits and risks of ENDS and information on national, state, and local regulations and compliance requirements.

  16. NOTES ON ADMINISTRATIVE LAW: Introduction 1. Administrative ...

    African Journals Online (AJOL)

    eliasn

    Independent agencies have also been created to regulate certain ... executive. In the political history of France there were events when courts ... ordinary courts also have a longstanding exclusive jurisdiction in the protection of personal ...

  17. Regelforenkling og administrative lettelser – med panden mod muren?

    DEFF Research Database (Denmark)

    Pedersen, Morten Jarlbæk; Pasquali, Simon

    2009-01-01

    Rule simplification is pivotal to many administrations today: Can the industry and business be regulated in a simpler and more efficient way? Since the 1980’s this question has spawned many attempts to reduce the administrative burdens in business. Many have failed though, and even the most...... the testing of four presumptions, which have their background in the classification of regulatory reforms and in that part of the regulation theory which emphasises the private interest as the main cause of regulation....

  18. Questions concerning constitutional law - Lander administration on behalf of the Federal Government

    International Nuclear Information System (INIS)

    Ossenbuehl, F.

    1991-01-01

    The lecture gives a basic perspective of a reform of the Laender administration on behalf of the Federal Government and first covers its nature, purpose and structure with respect to the atomic energy administration after the latest decisions of the Federal Constitutional Court. There follows a section on the constitutional and administrative reality of the Laender administration on behalf of the Federal Government as applied to atomic energy law, in which three conflict cases are pointed out. The last section gives an appraisal from the points of view of loyalty in execution, instruments of control (general administrative regulations - single directives - general directives), scope of the Laender administration on behalf of the Federal Government. It is determined whether the situations envisaged by the norms coincide with reality, where there are deficits and how they can be ameliorated by reform. As the Laender administration on behalf of the Federal Government is shaped on constitutional law it is only periphally accessible to an amendment of atomic energy law through normal legislation. (HSCH) [de

  19. The Political Economy of International Transitional Administration

    DEFF Research Database (Denmark)

    Grasten, Maj Lervad; Tzouvala, Ntina

    2018-01-01

    This article reconstructs how democratic participation and interference can be fended off by the construction of an international authoritarian political architecture and a strongly legalised and specific form of market economy. We do this by interrogating International Territorial Administration...... corporations. Even though the two administrations focused on different aspects of land and agriculture regulation, we argue that significant commonalities exist between their political preferences and interests. Our work draws on the tradition of critical legal studies in International Law (IL) and we posit...... that by drawing on this tradition, scholarship on post-conflict international territorial administration is better able to capture the long-term ramifications of international intervention....

  20. When do national administrations adapt to EU policies?

    DEFF Research Database (Denmark)

    Chatzopoulou, Sevasti

    2015-01-01

    This article joins the Europeanization studies and examines the administrative adaptation to Common Agricultural Policy (CAP), a highly institutionalized and regulated policy, in two small older member states, Denmark and Greece. The findings demonstrate variation in administrative adaptation....... In Denmark, both formal and informal administrative structures adapt to CAP, while in Greece administrative adaptation is limited to formal structures. This variation is attributed to two dimensions of the domestic institutional and organizational settings, namely “centralization” and “professionalism...

  1. What Does ‘Respect for Difference’ Mean?

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2013-01-01

    In his chapter, Laegaard (Chapter 2) focuses on liberal institutions. He questions the solidity of the distinction between ‘respect for difference’ and ‘respect for dignity’, by paying attention to what it means for institutions to respect difference. He concludes that from this perspective, the ...... how multiculturalism remains deeply connected to liberal values, even in its apparently more radical versions....

  2. Lesotho - Land Administration Reform

    Data.gov (United States)

    Millennium Challenge Corporation — Michigan State University was assigned to design the impact evaluation (IE) of the Land Administration Reform Project (LARP) funded under the Millennium Challenge...

  3. Understanding land administration systems

    DEFF Research Database (Denmark)

    P. Williamson, Ian; Enemark, Stig; Wallace, Judy

    2008-01-01

    This paper introduces basic land administration theory and highlights four key concepts that are fundamental to understanding modern land administration systems - firstly the land management paradigm and its influence on the land administration framework, secondly the role that the cadastre plays...... in contributing to sustainable development, thirdly the changing nature of ownership and the role of land markets, and lastly a land management vision that promotes land administration in support of sustainable development and spatial enablement of society. We present here the first part of the paper. The second...

  4. Security Administration Reports Application

    Data.gov (United States)

    Social Security Administration — Contains SSA Security Reports that allow Information Security Officers (ISOs) to access, review and take appropriate action based on the information contained in the...

  5. Veterans Administration Databases

    Science.gov (United States)

    The Veterans Administration Information Resource Center provides database and informatics experts, customer service, expert advice, information products, and web technology to VA researchers and others.

  6. Administrative Data Repository (ADR)

    Data.gov (United States)

    Department of Veterans Affairs — ADR provides an authoritative data store for shared administrative, demographic, enrollment, and eligibility information which is managed as a corporate asset. This...

  7. Collaborative Tax Regulation

    DEFF Research Database (Denmark)

    Boll, Karen

    2016-01-01

    This article shows a new form of regulation within a tax administration where tax administrators abate tax evasion by nudging and motivating consumers to only purchase services from tax compliant businesses. This indirectly closes or forces tax evading businesses to change their practices, because...... stakeholders, i.e. the consumers, in the regulatory craft. The study is based on a qualitative methodology and draws on a unique case of regulation in the cleaning sector. This sector is at high risk of tax evasion and human exploitation of vulnerable workers operating in the informal economy. The article has...

  8. Socio-Statistical Research on the Internalization of European Administrative Space Principles in the Romanian Public Administration

    OpenAIRE

    Matei, Ani; Matei, Lucica; Iancu, Diana-Camelia

    2011-01-01

    The authors propose an analysis of the public administration reform in Romania by assessing whether the Romanian civil servants perform their duties according to the regulations of the European Administrative Space. The paper offers a socio-statistic perspective on the internalization of the European Administrative Space principles, namely, the rule of law, openness towards citizens, and public administration responsibility in a Romanian context, after the European Union accession. Designed w...

  9. Self-esteem and social respect within the high school.

    Science.gov (United States)

    Yelsma, P; Yelsma, J

    1998-08-01

    A sample of 596 students in a Michigan high school completed 2 measures of self-esteem (S. Coopersmith, 1967; M. Rosenberg, 1979) and the English translation of the Social Behaviors Scale (M. Loranger, M. Poirier, D. Gauthier, & J. Talon, 1982). Factor analysis of the 36-item Social Behaviors Scale revealed 5 factors appropriate for assessing social respect. Regression analyses revealed that scores for total self-esteem and global self-esteem were significant predictors of total social respect. The scores for total self-esteem were also significantly associated with respect for teachers and for appropriate language. The females reported more respect for teachers, others, appropriate language, and physical property than the males did. The seniors reported more respect for appropriate language, teachers, and others than the freshmen did. Total self-esteem was significantly and negatively associated with respect for waiting and listening. Global self-esteem was significantly and negatively associated with respect for physical property.

  10. Measures and control: which mandatory regulations? which monitoring system to implement? what results to expect? which relations with the administration?; Mesures et controle: quelles obligations reglementaires? quel systeme de surveillance installer? quels resultats en attendre? quels rapports avec l`administration?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This workshop is composed of 7 papers on air pollution monitoring and control related to combustion plants and systems: after a presentation of the regulatory framework (at the French and European levels) concerning air pollution and combustion systems, the mechanisms for a clean and efficient combustion are detailed, followed by measures for a quality combustion, pollution emission reduction techniques during combustion, air pollution monitoring and monitors for environment and pollution sources, quality assessment of monitoring systems, automatic monitoring and control of systems and relations with the administration

  11. Caudal fourth ventricular administration of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside regulates glucose and counterregulatory hormone profiles, dorsal vagal complex metabolosensory neuron function, and hypothalamic Fos expression.

    Science.gov (United States)

    Ibrahim, Baher A; Tamrakar, Pratistha; Gujar, Amit D; Cherian, Ajeesh Koshy; Briski, Karen P

    2013-09-01

    This study investigated the hypothesis that estrogen controls hindbrain AMP-activated protein kinase (AMPK) activity and regulation of blood glucose, counterregulatory hormone secretion, and hypothalamic nerve cell transcriptional status. Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis. E advanced AICAR-induced increases in A2 phospho-AMPK (pAMPK) expression and in blood glucose levels and was required for augmentation of Fos, estrogen receptor-α (ERα), monocarboxylate transporter-2, and glucose transporter-3 protein in A2 neurons and enhancement of corticosterone secretion by this treatment paradigm. CV4 AICAR also resulted in site-specific modifications in Fos immunolabeling of hypothalamic metabolic structures, including the paraventricular, ventromedial, and arcuate nuclei. The current studies demonstrate that estrogen regulates AMPK activation in caudal hindbrain A2 noradrenergic neurons during pharmacological replication of energy shortage in this area of the brain, and that this sensor is involved in neural regulation of glucostasis, in part, through control of corticosterone secretion. The data provide unique evidence that A2 neurons express both ERα and -β proteins and that AMPK upregulates cellular sensitivity to ERα-mediated signaling during simulated energy insufficiency. The results also imply that estrogen promotes glucose and lactate uptake by these cells under those conditions. Evidence for correlation between hindbrain AMPK and hypothalamic nerve cell genomic activation provides novel proof for functional connectivity between this hindbrain sensor and higher order metabolic brain loci while demonstrating a modulatory role for estrogen in this interaction. Copyright © 2013 Wiley Periodicals, Inc.

  12. 26 CFR 1.52-3 - Limitations with respect to certain persons.

    Science.gov (United States)

    2010-04-01

    ... control, under § 1.52-1 (a) and (b). (b) Regulated investment companies and real estate investment trusts... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Limitations with respect to certain persons. 1.52-3 Section 1.52-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX...

  13. 48 CFR 970.5232-5 - Liability with respect to cost accounting standards.

    Science.gov (United States)

    2010-10-01

    ... cost accounting standards. 970.5232-5 Section 970.5232-5 Federal Acquisition Regulations System... cost accounting standards. As prescribed in 970.3270(a)(5), insert the following clause: Liability With Respect to Cost Accounting Standards (DEC 2000) (a) The Contractor is not liable to the Government for...

  14. Safety evaluation report by the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission for U.S. Energy Research and Development Administration Light Water Breeder Reactor. Special project No. 561

    International Nuclear Information System (INIS)

    1976-07-01

    The Safety Evaluation Report is presented for the Light Water Breeder Reactor (LWBR). The LWBR core is to be installed in the Shippingport reactor at the Shippingport Atomic Power Station. The Safety Evaluation Report is the result of an NRC staff review of the LWBR Safety Analysis Report submitted by the Division of Naval Reactors, U. S. Energy Research and Development Administration. As a result of its review, the NRC staff has recommended that: (1) a diverse trip signal, such as containment high pressure, be included in a 2-out-of-3 logic for initiation of safety injection; (2) power be locked out from the pressurizer surge isolation valve during normal operation; and (3) a chlorine monitor be installed in the main control room

  15. The development of regulations

    International Nuclear Information System (INIS)

    Slokan Dusic, D.; Levstek, M.F.; Stritar, A.

    2003-01-01

    In October 2002, The Act on Protection Against Ionising Radiation and Nuclear Safety which regulates all aspects of protection against ionising radiation and nuclear safety entered into force in Slovenia. The Slovenian government and its responsible ministries shall issue several governmental and ministerial regulations to support the above - mentioned act. The Slovenian Nuclear Safety Administration (SNSA) which acts within the Ministry of the Environment, Spatial Planing and Energy takes an active part in drafting the regulations which are defined in the act. Due to a very comprehensive and pretentious task, that is to be completed in a relatively short period of time, taking into consideration the involvement of stakeholders and all competent ministries, the SNSA within the Quality Management System developed a special procedure that insures the systematic approach to the preparation of regulations. The article will briefly represent the process that: defines the preparation, development, harmonisation, review, approval and issue of regulations and uniforms the format of developed regulations. (author)

  16. Understanding land administration systems

    DEFF Research Database (Denmark)

    P. Williamson, Ian; Enemark, Stig; Wallace, Judy

    2008-01-01

    This paper introduces basic land administration theory and highlights four key concepts that are fundamental to understanding modern land administration systems. Readers may recall the first part of the paper in October issue of Coordinates. Here is the concluding part that focuses on the changing...

  17. ADMINISTRATIVE RULEMAKING IN ETHIOPIA:

    African Journals Online (AJOL)

    MLR

    and the theoretical issues in relation to administrative legislation are discussed followed ..... that “laws properly so called” must be distinguished from morals and other ..... 44 William Wade, (1988), Administrative Law (Oxford University Press), p. .... 66 Rule 320, Rules of procedure and conduct of business in the Lok Sabha.

  18. Centos system administration essentials

    CERN Document Server

    Mallett, Andrew

    2014-01-01

    If you are a Linux administrator who is looking to gain knowledge that differentiates yourself from the crowd, then this is the book for you. Beginners who have a keen interest to learn more about Linux administration will also progress quickly with this resourceful learning guide.

  19. Postmodern Public Administration

    DEFF Research Database (Denmark)

    Bogason, Peter

    2005-01-01

    Discussion of the trends towards more uses of postmodern analysis within the discipline of public administration, particularly in the USA......Discussion of the trends towards more uses of postmodern analysis within the discipline of public administration, particularly in the USA...

  20. Alaska Administrative Manual

    Science.gov (United States)

    Search the Division of Finance site DOF State of Alaska Finance Home Content Area Accounting Charge Cards Division of Finance is to provide accounting, payroll, and travel services for State government Top Department of Administration logo Alaska Department of Administration Division of Finance Search

  1. Webmin administrator's cookbook

    CERN Document Server

    Karzynski, Michal

    2014-01-01

    Written in a cookbook format with practical recipes this book helps you to perform various administrative tasks using Webmin and enables you to perform common jobs more efficiently.This book is perfect for System administrators who want to learn more advanced concepts of Webmin and how it can help to set up a server for development, testing or deployment.

  2. Case and Administrative Support Tools

    Science.gov (United States)

    Case and Administrative Support Tools (CAST) is the secure portion of the Office of General Counsel (OGC) Dashboard business process automation tool used to help reduce office administrative labor costs while increasing employee effectiveness. CAST supports business functions which rely on and store Privacy Act sensitive data (PII). Specific business processes included in CAST (and respective PII) are: -Civil Rights Cast Tracking (name, partial medical history, summary of case, and case correspondance). -Employment Law Case Tracking (name, summary of case). -Federal Tort Claims Act Incident Tracking (name, summary of incidents). -Ethics Program Support Tools and Tracking (name, partial financial history). -Summer Honors Application Tracking (name, home address, telephone number, employment history). -Workforce Flexibility Initiative Support Tools (name, alternative workplace phone number). -Resource and Personnel Management Support Tools (name, partial employment and financial history).

  3. Land Administration Systems

    DEFF Research Database (Denmark)

    Enemark, Stig

    2014-01-01

    Land administration systems are the operational tool for conceptualizing rights, restrictions and responsibilities (RRRs) in land. Each of the rights, restrictions and responsibilities encompasses a human rights dimension that relates to the overall national land policies and should be unfolded...... as more than just rhetoric. This paper attempts to analyse the aspects of human rights in relation to land administration systems with a special focus on developing countries struggling to build adequate systems for governing the rights, restrictions and responsibilities in land. Human rights....... This relates to national political arrangements and standards for good governance and land administration systems are highly instrumental in this regard. This paper introduces the relation between land administration and human rights. It is argued that human rights and land administration are closely linked...

  4. 78 FR 66852 - State Fiscal Administration

    Science.gov (United States)

    2013-11-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services 42 CFR Part 433 State Fiscal Administration CFR Correction 0 In Title 42 of the Code of Federal Regulations, Parts 430 to 481, revised as of October 1, 2012, on page 98, in Sec. 433.50, paragraphs (a)(1)(i) and (a)(1)(ii...

  5. The legal nature of administrative detention

    Directory of Open Access Journals (Sweden)

    Adrian ALDEA

    2012-01-01

    Full Text Available Administrative or constabulary detention is the first measure involving deprivation of liberty that the police officers applies in extenso when initiating criminal investigations. Following the amendment of the jurisprudence of the European Court of Human Rights a more rigorous regulation of the circumstances and situations in which such a measure becomes effective is required

  6. 78 FR 46287 - Administrative Revisions to EPAAR

    Science.gov (United States)

    2013-07-31

    ..., such as copyrighted material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in http://www.regulations.gov Federal Register, or in hard... administrative formating error with ``Alternate l''. 31. 1552.232-74 is amended to add ``Contracting Officer's...

  7. Small Business Administration Semiannual Regulatory Agenda

    Science.gov (United States)

    2010-04-26

    ... Strategic Planning, Small Business Administration, 409 Third Street SW, Washington, DC 20416 Phone: 202 205... Protest and Appeal Regulations 294 Small Business Size Standards: Retail Trade Industries 3245-AF69 295... STANDARDS: RETAIL TRADE INDUSTRIES Legal Authority: 15 USC 632(a) Abstract: The U.S. Small Business...

  8. Legal Considerations in Cooperative Education Administration.

    Science.gov (United States)

    Hunt, Donald C.

    The laws, regulations, and rulings that are common to all cooperative education programs and that frequently present problems to coordinators, faculty, administrators, and employers are briefly explained. The objective is to provide coordinators of cooperative programs in education, business, industry, and government with a discussion of the…

  9. 15 CFR 990.61 - Administrative record.

    Science.gov (United States)

    2010-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION ACT REGULATIONS... have completed restoration planning, as provided in §§ 990.55 and 990.56 of this part, they must close... constructive notice of the Draft Restoration Plan and the opportunity to comment on the plan; (2) Do not...

  10. Reducing the cost of administrative justice

    International Nuclear Information System (INIS)

    Tourtellotte, J.R.

    1982-01-01

    In virtually every sector of government regulation, the complaint has been lodged that the costs of administrative justice are too high. These costs in time, money, resources, and productivity can have a profound effect on the individual consumer. When applied to an energy technology such as nuclear power, costs of administrative justice can transcent time and money to have even more profound and pervasive soeietal effects. Societal costs can be expressed in terms of their impact on important national concerns, that is, the standard of living, technological superiority, and the national energy equation. Some views are presented on the interests involved in the regulation of nuclear power and what can be done to bring those interests into better balance so as to reduce the cost of administrative justice

  11. Home - Defense Technology Security Administration

    Science.gov (United States)

    by @dtsamil Defense Technology Security Administration Mission, Culture, and History Executive Official seal of Defense Technology Security Administration Official seal of Defense Technology Security Administration OFFICE of the SECRETARY of DEFENSE Defense Technology Security Administration

  12. Electronic Code of Federal Regulations

    Data.gov (United States)

    National Archives and Records Administration — The Electronic Code of Federal Regulations (e-CFR) is the codification of the general and permanent rules published in the Federal Register by the executive...

  13. BRAZILIAN ADMINISTRATION, ADMINISTRATIVE REFORM AND THE NEW STATE: THE ROLE OF ADMINISTRATIVE APPARATUS IN VARGAS ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Emerson Moura

    2016-07-01

    Full Text Available The role played by the administrative apparatus through the Department of Administrative Services in the Government policy Vargas is the object put in debate. Analyzes the theme from the the investigation of patrimonial, authoritarian and inefficient context which marks the formation and development of administrative bureaucracy, the tenders of professionalization and efficiency brought by the administrative reforms of the 1930s and 1940s with the contrast of the limitations of the import of the Weberian model in the Brazilian context and analysis of the establishment of the New State DASP and their assignments. Search the work demonstrate the control position he held directly and through the State Departments in the Brazilian Public Administration ensuring centralized and developmental policy of the government. For this is adopted as the research method of approach structuralism in order to identify the deconstruction of the phenomenon - of administrative reforms - in the superficial perception - the proposed impersonality and efficiency as the best way of achieving the public interest - its invariant structure - the search for the adequacy of the administrative apparatus and bureaucracy for pursuit of political ends pursued by the Government.

  14. Contempt as the absence of appraisal, not recognition, respect.

    Science.gov (United States)

    Mason, Michelle

    2017-01-01

    Gervais & Fessler's defense of a sentiment construct for contempt captures features distinguishing the phenomenon from basic emotions and highlights the fact that it comprises a coordinated syndrome of responses. However, their conceptualization of contempt as the absence of respect equivocates. Consequently, a "dignity" culture that prescribes respect does not thereby limit legitimate contempt in the manner the authors claim.

  15. Kant's Conception of Respect and African American Education Rights

    Science.gov (United States)

    Bynum, Gregory Lewis

    2011-01-01

    Immanuel Kant envisioned a kind of respect in which one recognizes each human (1) as being not fully comprehensible by any human understanding, (2) as being an end in him- or herself, and (3) as being a potential source of moral law. In this essay, Gregory Lewis Bynum uses this conception of respect as a lens with which to examine African American…

  16. Quantum mechanics with respect to different reference frames

    International Nuclear Information System (INIS)

    Mangiarotti, L.; Sardanashvily, G.

    2007-01-01

    Geometric (Schroedinger) quantization of nonrelativistic mechanics with respect to different reference frames is considered. In classical nonrelativistic mechanics, a reference frame is represented by a connection on a configuration space fibered over a time axis R. Under quantization, it yields a connection on the quantum algebra of Schroedinger operators. The operators of energy with respect to different reference frames are examined

  17. Relocating Respect and Tolerance: A Practice Approach in Empirical Philosophy

    Science.gov (United States)

    Anker, Trine; Afdal, Geir

    2018-01-01

    Respect and tolerance are key values in education. They are also among the aims of education and are brought to the foreground in educational policy. We argue that these values are neither philosophically nor politically given aims for which education is a means. Instead, respect and tolerance are enacted and negotiated through educational…

  18. The Problematic Promotion of Abstinence: An Overview of Sex Respect.

    Science.gov (United States)

    Goodson, Patricia; Edmundson, Elizabeth

    1994-01-01

    Presents the results of a content evaluation of the abstinence-based sexuality education curriculum, "Sex Respect," focusing on the curriculum's message and presentation. Results indicate Sex Respect omits basic content and includes misinformation, especially in the areas of human sexual response and reproductive health, and needs revision.…

  19. Pro Linux System Administration

    CERN Document Server

    Turnbull, James

    2009-01-01

    We can all be Linux experts, provided we invest the time in learning the craft of Linux administration. Pro Linux System Administration makes it easy for small to medium--sized businesses to enter the world of zero--cost software running on Linux and covers all the distros you might want to use, including Red Hat, Ubuntu, Debian, and CentOS. Authors, and systems infrastructure experts James Turnbull, Peter Lieverdink, and Dennis Matotek take a layered, component--based approach to open source business systems, while training system administrators as the builders of business infrastructure. If

  20. Administration and Jurisdictional Policy

    Directory of Open Access Journals (Sweden)

    Eduardo Hernando Nieto

    2009-06-01

    Full Text Available To what extent does studying jurisdictional politics need the knowledge of different administrative theories in general and the science of public administration in particular? This small text proposes such reflection and comes to the conclusion that it is impossible to propose a new approximation to this topic without considering the administrative theory, for that the specialists and thinkers will get more with the contact of this discipline from what it is called a multidisciplinary approach.

  1. Administration of radioisotope production

    International Nuclear Information System (INIS)

    1964-01-01

    Current developments in atomic energy, and the administrative problems to which they give rise, were surveyed in a seminar on 'Atomic Energy for Atomic Energy Administrators' held at IAEA headquarters from 30 September to 4 October 1963. The ground covered included protection against radiation, isotopes and radiation sources, research reactors, nuclear power, legal matters, technical and scientific administration, the role of the universities, and the Agency's part in assistance to developing countries. The possibilities and limitations of radioisotope production from research reactors were discussed by Dr. G. B. Cook, of the Division of Research and Laboratories, IAEA in this paper.

  2. Administration of radioisotope production

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1964-01-15

    Current developments in atomic energy, and the administrative problems to which they give rise, were surveyed in a seminar on 'Atomic Energy for Atomic Energy Administrators' held at IAEA headquarters from 30 September to 4 October 1963. The ground covered included protection against radiation, isotopes and radiation sources, research reactors, nuclear power, legal matters, technical and scientific administration, the role of the universities, and the Agency's part in assistance to developing countries. The possibilities and limitations of radioisotope production from research reactors were discussed by Dr. G. B. Cook, of the Division of Research and Laboratories, IAEA in this paper.

  3. Administrative Circulars Rev.

    CERN Multimedia

    2003-01-01

    Administrative Circular N° 19 (Rev. 3) - April 2003 Subsistence indemnity - Other expenses necessarily incurred in the course of duty travelAdministrative Circular N° 25 (Rev. 2) - April 2003 Shift work - Special provisions for the Fire and Rescue Service - These circulars have been revised. Human Resources Division Tel. 74128Copies of these circulars are available in the Divisional Secretariats. In addition, administrative and operational circulars, as well as the lists of those in force, are available for consultation on the Web at: http://humanresources.web.cern.ch/humanresources/internal/admin_services/admincirc/listadmincirc.asp

  4. Publication of administrative circular

    CERN Multimedia

    HR Department

    2009-01-01

    ADMINISTRATIVE CIRCULAR NO. 23 (REV. 2) – SPECIAL WORKING HOURS Administrative Circular No. 23 (Rev. 2) entitled "Special working hours", approved following discussion in the Standing Concertation Committee on 9 December 2008, will be available on the intranet site of the Human Resources Department as from 19 December 2008: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 23 (Rev. 1) entitled "Stand-by duty" of April 1988. A "Frequently Asked Questions" information document on special working hours will also be available on this site. Paper copies of this circular will shortly be available in Departmental Secretariats. Human Resources Department Tel. 78003

  5. PUBLICATION OF ADMINISTRATIVE CIRCULAR

    CERN Multimedia

    HR Department

    2008-01-01

    ADMINISTRATIVE CIRCULAR NO. 23 (REV. 2) – SPECIAL WORKING HOURS Administrative Circular No. 23 (Rev. 2) entitled "Special working hours", approved following discussion in the Standing Concertation Committee meeting of 9 December 2008, will be available on the intranet site of the Human Resources Department as from 19 December 2008: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 23 (Rev. 1) entitled "Stand-by duty" of April 1988. A "Frequently Asked Questions" information document on special working hours will also be available on this site. Paper copies of this circular will shortly be available in departmental secretariats. Human Resources Department Tel. 78003

  6. 28 CFR 0.64-3 - Delegation respecting designation of certain Department of Agriculture employees (Tick Inspectors...

    Science.gov (United States)

    2010-07-01

    ... Division § 0.64-3 Delegation respecting designation of certain Department of Agriculture employees (Tick... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Delegation respecting designation of certain Department of Agriculture employees (Tick Inspectors) to carry and use firearms. 0.64-3 Section 0...

  7. Regulating the Regulator

    Energy Technology Data Exchange (ETDEWEB)

    1992-08-26

    The article reports on a challenge to the UK electricity regulator to defend his record by the Coalition for Fair Electricity Regulation (COFFER). The challenge centres on whether the obligation for the regional electric companies (REC) to purchase power from the cheapest source is being enforced. This is related to the wider issue of whether the REC's support of combined-cycle gas turbine (CCGT) is economic. COFFER considers that uneconomic gas-fired power plants are being allowed to displace economic coal-fired stations. Aspects discussed include the background to the dispute and the costs of CCGT and coal fired power generation. 1 fig., 1 tab.

  8. Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC/Nga mice.

    Science.gov (United States)

    Kim, Dong-Young; Jung, Jung-A; Kim, Tae-Ho; Seo, Sang-Wan; Jung, Sung-Ki; Park, Cheung-Seog

    2009-04-21

    Uncariae rhynchophylla (UR) is an herb which has blood pressure lowering and anti-inflammatory effects and has been prescribed traditionally to treat stroke and vascular dementia. In the present study, we examined whether UR suppress Atopic dermatitis (AD)-like skin lesions in NC/Nga mice treated with 2, 4-dinitrofluorobenzene (DNFB) under SPF conditions. The effect of UR in DNFB- treated NC/Nga mice was determined by measuring the skin symptom severity, levels of serum IgE, and of the amounts of IL-4 and IFN-gamma secreted by activated T cells in draining lymph nodes. Oral administration of UR to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. IFN-gamma production by CD4+ T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by UR treatment, although levels of IL-4 and total IgE in serum were not. UR may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-gamma production.

  9. Nature and scope of public administration

    Directory of Open Access Journals (Sweden)

    Uchem, R.O.

    2013-03-01

    Full Text Available The success and survival of any organizations be they government or not is contingent upon group efforts and cooperation to achieve set goals. This paper discusses the nature and scope of public administration to say that in modern day societies, any administration in the public interest transcends beyond government circles and finds expression in other spheres of human endeavors including the church, mosques, postal services as well as international relations and diplomacy, respectively. The paper discusses the concepts of administration and public administration thereby creating a distinction between the two concepts. Furthermore, the understanding of the scope of administration through the various schools of thought have also been captured, the essence of which is to generate a clearer understanding of the discourse under review. The paper ends with conclusions.

  10. The Analysis of the Cost and Benefit About Government Regulation Under the Administrative Law---Taking License Plate Limit in Six Cities as the Example%行政法下政府规制成本与收益分析--以全国六个城市的限牌令为例

    Institute of Scientific and Technical Information of China (English)

    廖丽环

    2015-01-01

    限牌令的本质是政府规制工具当中的命令控制型工具,也是行政特许的一种。尽管就适当性原则的目的审查而言,限牌令的施行有合理的现实需求和考虑,但就合法性审查而言,仍然遭遇规制主体不独立、程序不合法的困境。探究限牌令是否在其他城市具有可复制性,要借助政府规制的成本与效益分析。具体而言,成本分析应考虑规制工具的选择因素以及立法、执法成本;效益分析应着重于风险和收益的平衡。据此,在中国语境下,政府规制应立足于提高规制型公共政策的可接受性、加强公私协力和自主规制在社会管理中的应用、发展公众参与型行政、完善替代性方案。%License plate limit in essence is one of the government regulation tools—command and control tool, which also belongs to the administrative franchise.Although license plate limit has reasonable practical needs from purpose review of rational principle, in terms of legality review, some problems still remain unsolved:lack of inde-pendent regulatory body and the legal procedure.As for whether or not license plate limit can be copied in other cities, the analysis of the cost and benefit about government regulation becomes vital.Specifically, the cost analysis should consider choice of a regulatory tool and the cost of legislation and enforcement while benefit analysis should focus on the balance between risks and benefits.Accordingly, under Chinese context, government regulation must be based on improving the acceptability of the public policy regulation, strengthening the application of public-private partnership and the independent regulation in social management, developing the administration with the participation of the public and perfecting the plans for alternative.

  11. Refining the Rules of the Game: The Corporate Responsibility to Respect Human Rights

    Directory of Open Access Journals (Sweden)

    Justine Nolan

    2014-02-01

    Full Text Available The growth of transnational corporations over the past few decades has been paralleled by concerns to find ways of regulating the deleterious impacts on human rights by the ever-increasing number of companies whose corporate tentacles stretch across national boundaries and beyond the reach of traditional corporate control mechanisms. The steady evolution of a global social expectation that companies should respect international human rights standards, combined with the occasional foray by states in adopting an expansive approach to protecting rights, is changing the nature and possibility of developing a firmer basis for corporate accountability for human rights. What we are witnessing is a process of re-regulation whereby state and non-state actors are utilizing a combination of public and private regulation to improve the framework for corporate rights compliance. The regulation of corporate activity with respect to human rights requires a multiplicity of stakeholders and a very nuanced mix of public and private regulation that may be difficult to replicate easily across different sectors, states and cultural boundaries. 

  12. R-E-S-P-E-C-T: The Relationship Between Being Respected and Quality of Life of Disabled People

    Directory of Open Access Journals (Sweden)

    Carli Friedman

    2018-05-01

    Full Text Available The United Nations exclaims "all human beings have the right to be treated with dignity and respect" (Annan, 2005, p. 34. Yet, disabled people have long been denied respect in the United States and have been subjected to disability oppression and ableism. For these reasons, the aim of this study was to explore the relationship between respect and disability, particularly respect's impact on the quality of life of disabled people. We had two research questions: (1. what factors predict disabled people being respected? and, (2. how does being respected impact the quality of life of disabled people? To explore these questions, we used secondary Personal Outcome Measures® data from approximately 1,500 disabled people; we analyzed this data to examine relationships between disabled people's interpretations of feeling and being respected, and their quality of life. Our findings revealed being respected had a significant impact on every area of ones' quality of life. Problematically, this also included areas which should be considered non-negotiable fundamental human and civil rights, that should not depend on if, and how, people respect disabled people. While the attitudes underlying the disrespect of disabled people are harmful and problematic, human and civil rights should be inalienable – ones' access to exercise their rights, to safety, to health, and to many other domains should not depend on others' attitudes about, and treatment toward, you.

  13. Administration of Anesthesia

    Medline Plus

    Full Text Available ... Anesthesia Evaluation Part V Broad Access to Care, Patient Safety and Comfort Oral and maxillofacial surgeons (OMSs) are trained in all aspects of anesthesia administration. Following dental ... evaluate patients for anesthesia, deliver the anesthetic and monitor post- ...

  14. Transportation Security Administration

    Science.gov (United States)

    ... content Official website of the Department of Homeland Security Transportation Security Administration A - Z Index Blog What Can I ... Search form Search the Site Main menu Travel Security Screening Special Procedures TSA Pre✓® Passenger Support Travel ...

  15. Administration of Anesthesia

    Medline Plus

    Full Text Available ... OMSs) are trained in all aspects of anesthesia administration. Following dental school, they complete at least four years of training in a hospital-based surgical residency program alongside medical residents in ...

  16. Spatially enabled land administration

    DEFF Research Database (Denmark)

    Enemark, Stig

    2006-01-01

    enabling of land administration systems managing tenure, valuation, planning, and development will allow the information generated by these activities to be much more useful. Also, the services available to private and public sectors and to community organisations should commensurably improve. Knowledge....... In other words: Good governance and sustainable development is not attainable without sound land administration or - more broadly – sound land management. The paper presents a land management vision that incorporates the benefits of ICT enabled land administration functions. The idea is that spatial...... the communication between administrative systems and also establish more reliable data due to the use the original data instead of copies. In Denmark, such governmental guidelines for a service-oriented ITarchitecture in support of e-government are recently adopted. Finally, the paper presents the role of FIG...

  17. Humanism, Administration and Education

    DEFF Research Database (Denmark)

    Plum, Maja

    2012-01-01

    are not restricted to the administrative practices, but are part of education and its humanistic legacy as well. As such, the administrative demand of documentation becomes possible and recognisable through its reproductive elements. Elements that are constituted in a transformative conjunction in which......Abstract Through the example of a Danish reform of educational plans in early childhood education, this paper analyses the emergence of a new pedagogical desire related to administrative educational reforms promoting accountability, visibility and documentation. Two arguments are made: first......, it is argued that the changes in administrative practices during the last decade constitute a transformation, but also a reproduction of relations between knowledge and governing that goes back to the big expansion of the welfare state. Second, it is argued that these relations between knowledge and governing...

  18. Scientists vs. the administration

    CERN Multimedia

    2004-01-01

    Article denouncing the supposed impartiality of signatories of a report released by the Union of Concerned Scientists (UCS), which accused the Bush administration of systemically suborning objective science to a political agenda (1 page).

  19. Veterans Health Administration (VHA)

    Data.gov (United States)

    Social Security Administration — The purpose of this agreement is for SSA to verify SSNs and other identifying information for the Department of Veterans Affairs, VHA. DVA will use the information...

  20. EUROPEAN ACCOUNTING REGULATION - HISTORY AND PERSPECTIVES

    Directory of Open Access Journals (Sweden)

    Mariana Farcas

    2014-07-01

    Full Text Available The first directive regarding the financial reporting at the level of European Union is published in 1978 (The Fourth Directive and whereas its content does not refer to the group companies, this directive was supplemented by another directive (The Seventh Directive published in 1983. The two directives regulate in parallel the issues concerning the preparing of the annual financial statements of individual companies, respectively of the group companies. Since 2008 have begun to take shape the point of views regarding the need of the development and publication of some regulations to simplify and to reduce the administrative burdens of the companies, including on the issue of financial reporting. The steps in the direction of simplification of the regulation in accounting area have resulted in June 2013 in The 34th Directive regarding the annual financial statements, the consolidated financial statements and the related reports of certain types of companies. As a member of the European Union, Romania must take into account the implementation of the European legislation in all areas, including in the field of accounting. In this respect, The Fourth Directive regarding the annual accounts of certain types of companies and The Seventh Directive regarding the consolidated accounts have been transposed into Romanian legislation since 2006 through OMFP 1752/2005 when the Romanian accounting regulations have become in accordance to the European directives and not only harmonized with these, and OMFP 3055/2009 brings additional information concerning the rules relating to the consolidation of accounts.

  1. SELinux policy administration

    CERN Document Server

    Vermeulen, Sven

    2013-01-01

    A step-by-step guide to learn how to set up security on Linux servers by taking SELinux policies into your own hands.Linux administrators will enjoy the various SELinux features that this book covers and the approach used to guide the admin into understanding how SELinux works. The book assumes that you have basic knowledge in Linux administration, especially Linux permission and user management.

  2. Learning Cassandra for administrators

    CERN Document Server

    Parthasarathy, Vijay

    2013-01-01

    This book is a practical, hands-on guide, taking the reader from the basics of using Cassandra though to the installation and the running.Learning Cassandra for Administrators is for administrators who manage a large deployment of Cassandra clusters, and support engineers who would like to install the monitoring tools and who are also in charge of making sure the cluster stays the same, ensuring that the service is always up and running.

  3. Human factoring administrative procedures

    International Nuclear Information System (INIS)

    Grider, D.A.; Sturdivant, M.H.

    1991-01-01

    In nonnuclear business, administrative procedures bring to mind such mundane topics as filing correspondence and scheduling vacation time. In the nuclear industry, on the other hand, administrative procedures play a vital role in assuring the safe operation of a facility. For some time now, industry focus has been on improving technical procedures. Significant efforts are under way to produce technical procedure requires that a validated technical, regulatory, and administrative basis be developed and that the technical process be established for each procedure. Producing usable technical procedures requires that procedure presentation be engineered to the same human factors principles used in control room design. The vital safety role of administrative procedures requires that they be just as sound, just a rigorously formulated, and documented as technical procedures. Procedure programs at the Tennessee Valley Authority and at Boston Edison's Pilgrim Station demonstrate that human factors engineering techniques can be applied effectively to technical procedures. With a few modifications, those same techniques can be used to produce more effective administrative procedures. Efforts are under way at the US Department of Energy Nuclear Weapons Complex and at some utilities (Boston Edison, for instance) to apply human factors engineering to administrative procedures: The techniques being adapted include the following

  4. "When Meeting 'Khun' Teacher, Each Time We Should Pay Respect": Standardizing Respect in a Northern Thai Classroom

    Science.gov (United States)

    Howard, Kathryn M.

    2009-01-01

    This paper examines how Northern Thai (Muang) children are socialized into the discourses and practices of respect in school, a process that indexically links Standard Thai to images of polite and respectful Thai citizenship. Focusing on the socialization of politeness particles, the paper examines how cultural models of conduct are taken up,…

  5. What deserves our respect? Reexamination of respect for autonomy in the context of the management of chronic conditions.

    Science.gov (United States)

    Enzo, Aya; Okita, Taketoshi; Asai, Atsushi

    2018-05-29

    The global increase in patients with chronic conditions has led to increased interest in ethical issues regarding such conditions. A basic biomedical principle-respect for autonomy-is being reexamined more critically in its clinical implications. New accounts of this basic principle are being proposed. While new accounts of respect for autonomy do underpin the design of many public programs and policies worldwide, addressing both chronic disease management and health promotion, the risk of applying such new accounts to clinical setting remain understudied. However, the application of new accounts of respect for autonomy to clinical settings could support disrespectful attitudes toward or undue interference with patients with chronic conditions. Reconsidering autonomy and respect using Kantian accounts, this paper proposes respect for persons as an alternative basic bioethical principle to respect for autonomy. Unlike the principle of respect for persons in the Belmont Report, our principle involves respecting any patient's decisions, behaviors, emotions, or life-style regardless of his or her "autonomous" capabilities. Thus, attitudes toward patients should be no different irrespective of the assessment of their decisional or executive capabilities.

  6. Lipschitz estimates for convex functions with respect to vector fields

    Directory of Open Access Journals (Sweden)

    Valentino Magnani

    2012-12-01

    Full Text Available We present Lipschitz continuity estimates for a class of convex functions with respect to Hörmander vector fields. These results have been recently obtained in collaboration with M. Scienza, [22].

  7. Volunteering for charity: pride, respect, and the commitment of volunteers.

    Science.gov (United States)

    Boezeman, Edwin J; Ellemers, Naomi

    2007-05-01

    This study builds upon and extends the social-identity-based model of cooperation with the organization (T. R. Tyler, 1999; T. R. Tyler & S. L. Blader, 2000) to examine commitment and cooperative intent among fundraising volunteers. In Study 1, structural equation modeling indicated that pride and respect related to the intent to remain a volunteer with an organization, and that this relation was mediated primarily by normative organizational commitment. In Study 2, structural equation modeling indicated that the perceived importance of volunteer work was related to pride, that perceived organizational support related to the experience of respect, and that pride and respect mediated the relation between perceived importance and support on the one hand and organizational commitment on the other. Overall, the results suggest that volunteer organizations may do well to implement pride and respect in their volunteer policy, for instance to address the reliability problem (J. L. Pearce, 1993). 2007 APA, all rights reserved

  8. Do positrons and antiprotons respect the weak equivalence principle?

    International Nuclear Information System (INIS)

    Hughes, R.J.

    1990-01-01

    We resolve the difficulties which Morrison identified with energy conservation and the gravitational red-shift when particles of antimatter, such as the positron and antiproton, do not respect the weak equivalence principle. 13 refs

  9. Constrained multi-degree reduction with respect to Jacobi norms

    KAUST Repository

    Ait-Haddou, Rachid; Barton, Michael

    2015-01-01

    We show that a weighted least squares approximation of Bézier coefficients with factored Hahn weights provides the best constrained polynomial degree reduction with respect to the Jacobi L2L2-norm. This result affords generalizations to many previous findings in the field of polynomial degree reduction. A solution method to the constrained multi-degree reduction with respect to the Jacobi L2L2-norm is presented.

  10. Constrained multi-degree reduction with respect to Jacobi norms

    KAUST Repository

    Ait-Haddou, Rachid

    2015-12-31

    We show that a weighted least squares approximation of Bézier coefficients with factored Hahn weights provides the best constrained polynomial degree reduction with respect to the Jacobi L2L2-norm. This result affords generalizations to many previous findings in the field of polynomial degree reduction. A solution method to the constrained multi-degree reduction with respect to the Jacobi L2L2-norm is presented.

  11. Regulation as Rhetoric

    DEFF Research Database (Denmark)

    Boll, Karen; Györy, Csaba

    This paper analyses the way regulatory agencies strategically use public ‘rhetoric’ and ‘management of appearance’ to strengthen their regulation. It reports a comparative study of the Securities and Exchange Commission (SEC) which is the US federal securities regulator and the Danish Tax...... and Customs Administration (SKAT) which is the national tax regulator in Denmark. SEC operates in a US context where the agency fights to get trust, while SKAT operates in a context where high trust in public agencies is a basic condition. We argue, however, that despite the radically different institutional...... engage reflectively in image promotion which serves two purposes: establishing and maintaining legitimacy in a particular social and political environment and producing compliance. Further, we argue that this regulation is a form of ‘post-bureaucratic’ regulation in which compliance is achieved...

  12. Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Corrales, Andrea; Parisotto, Eduardo B; Vidal, Verónica; García-Cerro, Susana; Lantigua, Sara; Diego, Marian; Wilhem Filho, Danilo; Sanchez-Barceló, Emilio J; Martínez-Cué, Carmen; Rueda, Noemí

    2017-09-15

    Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome. Here, we investigated the effects of pre- and post-natal melatonin treatment on behavioral and cognitive abnormalities and on several neuromorphological alterations (hypocellularity, neurogenesis impairment and increased oxidative stress) that appear during the early developmental stages in TS mice. Pregnant TS females were orally treated with melatonin or vehicle from the time of conception until the weaning of the offspring, and the pups continued to receive the treatment from weaning until the age of 5 months. Melatonin administered during the pre- and post-natal periods did not improve the cognitive impairment of TS mice as measured by the Morris Water maze or fear conditioning tests. Histological alterations, such as decreased proliferation (Ki67+ cells) and hippocampal hypocellularity (DAPI+ cells), which are typical in TS mice, were not prevented by melatonin. However, melatonin partially regulated brain oxidative stress by modulating the activity of the primary antioxidant enzymes (superoxide dismutase in the cortex and catalase in the cortex and hippocampus) and slightly decreasing the levels of lipid peroxidation in the hippocampus of TS mice. These results show the inability of melatonin to prevent cognitive impairment in TS mice when it is administered at pre- and post-natal stages. Additionally, our findings suggest that to induce pro-cognitive effects in TS mice during the early stages of development, in addition to attenuating oxidative stress, therapies should aim to improve other altered processes, such as hippocampal neurogenesis and/or hypocellularity. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Educational Administration and the Social, Policy, and Administrative Sciences.

    Science.gov (United States)

    Kirkpatrick, Samuel A.

    1983-01-01

    The politics of education has been ignored in educational administration programs; it has been not enough taught in American programs for educational administrators and not enough emphasized in discussions of administrative roles. Administration increasingly includes political as well as rational decisions. Thus, administrators need a unified…

  14. The complexities of HIPAA and administration simplification.

    Science.gov (United States)

    Mozlin, R

    2000-11-01

    The Health Insurance Portability and Accessibility Act (HIPAA) was signed into law in 1996. Although focused on information technology issues, HIPAA will ultimately impact day-to-day operations at multiple levels within any clinical setting. Optometrists must begin to familiarize themselves with HIPAA in order to prepare themselves to practice in a technology-enriched environment. Title II of HIPAA, entitled "Administration Simplification," is intended to reduce the costs and administrative burden of healthcare by standardizing the electronic transmission of administrative and financial transactions. The Department of Health and Human Services is expected to publish the final rules and regulations that will govern HIPAA's implementation this year. The rules and regulations will cover three key aspects of healthcare delivery: electronic data interchange (EDI), security and privacy. EDI will standardize the format for healthcare transactions. Health plans must accept and respond to all transactions in the EDI format. Security refers to policies and procedures that protect the accuracy and integrity of information and limit access. Privacy focuses on how the information is used and disclosure of identifiable health information. Security and privacy regulations apply to all information that is maintained and transmitted in a digital format and require administrative, physical, and technical safeguards. HIPAA will force the healthcare industry to adopt an e-commerce paradigm and provide opportunities to improve patient care processes. Optometrists should take advantage of the opportunity to develop more efficient and profitable practices.

  15. The effects of acute administration of Chinese aphrodisiacs sold in ...

    African Journals Online (AJOL)

    The effects of acute administration of Chinese aphrodisiacs sold in Blantyre City on sperm characteristics and fertility profile in guinea pigs. ... However, selling of these drugs seems not to be well regulated. Probably the aphrodisiacs that are ...

  16. 27 CFR 10.5 - Delegations of the Administrator.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS COMMERCIAL BRIBERY Scope of Regulations § 10.5 Delegations of the... Administrator's Authorities in 27 CFR Part 10, Commercial Bribery. You may obtain a copy of this order by...

  17. Market, Regulation, Market, Regulation

    DEFF Research Database (Denmark)

    Frankel, Christian; Galland, Jean-Pierre

    2015-01-01

    barriers to trade in Europe, realized the free movement of products by organizing progressively several orders of markets and regulation. Based on historical and institutional documents, on technical publications, and on interviews, this article relates how the European Commission and the Member States had......This paper focuses on the European Regulatory system which was settled both for opening the Single Market for products and ensuring the consumers' safety. It claims that the New Approach and Standardization, and the Global Approach to conformity assessment, which suppressed the last technical...... alternatively recourse to markets and to regulations, at the three main levels of the New Approach Directives implementation. The article focuses also more specifically on the Medical Devices sector, not only because this New Approach sector has long been controversial in Europe, and has recently been concerned...

  18. Forum | Accelerating respect @ CERN | 5 May | Council Chamber

    CERN Multimedia

    2015-01-01

    Forum for discussion: Accelerating respect @ CERN - What does this mean in our daily working lives?   Tuesday, 5 May at 2 p.m. Council Chamber Join our forum for discussion on the topic of “Respect in the workplace” where Alan Richter will be leading a discussion on the relationship between respect and trust, including some recent research on trust, and exploring the role of unconscious bias, how respect is differently interpreted across cultures, and the connection between respect, listening, and the appreciative inquiry process. Alan Richter is the president of QED Consulting, a 26-year-old company based in New York. He has consulted to organisations in the areas of leadership, values, culture and change and is a recognised pioneer in global diversity and international ethics. He has worked with CERN, NASA, the UN and many global companies and leading universities around the world. He has a Ph.D. in Philosophy from London University, and a Master’s degree fro...

  19. Linux System Administration

    CERN Document Server

    Adelstein, Tom

    2007-01-01

    If you're an experienced system administrator looking to acquire Linux skills, or a seasoned Linux user facing a new challenge, Linux System Administration offers practical knowledge for managing a complete range of Linux systems and servers. The book summarizes the steps you need to build everything from standalone SOHO hubs, web servers, and LAN servers to load-balanced clusters and servers consolidated through virtualization. Along the way, you'll learn about all of the tools you need to set up and maintain these working environments. Linux is now a standard corporate platform with user

  20. Pro Python System Administration

    CERN Document Server

    Sileika, R

    2010-01-01

    As time goes on, system administrators are presented with increasingly complicated challenges. In the early days, a team of engineers might have had to look after one or two systems. These days, one engineer can administer hundreds or thousands of systems. System administrators are gradually replacing their tools with more advanced and flexible ones. One of the choices is Python. Structurally, Python is a modern, high-level language with a very clean syntax. Python comes with many built-in libraries that can make automation tasks easier. It also has extensive set of third-party libraries and a

  1. Computer hardware fault administration

    Science.gov (United States)

    Archer, Charles J.; Megerian, Mark G.; Ratterman, Joseph D.; Smith, Brian E.

    2010-09-14

    Computer hardware fault administration carried out in a parallel computer, where the parallel computer includes a plurality of compute nodes. The compute nodes are coupled for data communications by at least two independent data communications networks, where each data communications network includes data communications links connected to the compute nodes. Typical embodiments carry out hardware fault administration by identifying a location of a defective link in the first data communications network of the parallel computer and routing communications data around the defective link through the second data communications network of the parallel computer.

  2. Practical JIRA Administration

    CERN Document Server

    Doar, Matthew

    2011-01-01

    If you're familiar with JIRA for issue tracking, bug tracking, and other uses, you know it can sometimes be tricky to set up and manage. In this concise book, software toolsmith Matt Doar clarifies some of the more confusing aspects by answering difficult and frequently asked questions about JIRA administration. Practical JIRA Administration shows you how JIRA is intended to be used, making it an ideal supplement to the extensive documentation already available. The book's chapters are loosely connected, so you can go straight to the information that best serves your needs. Understand the di

  3. River basin administration

    Science.gov (United States)

    Management of international rivers and their basins is the focus of the Centre for Comparative Studies on (International) River Basin Administration, recently established at Delft University of Technology in the Netherlands. Water pollution, sludge, and conflicting interests in the use of water in upstream and downstream parts of a river basin will be addressed by studying groundwater and consumption of water in the whole catchment area of a river.Important aspects of river management are administrative and policy aspects. The Centre will focus on policy, law, planning, and organization, including transboundary cooperation, posing standards, integrated environmental planning on regional scale and environmental impact assessments.

  4. 7 CFR 371.2 - The Office of the Administrator.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false The Office of the Administrator. 371.2 Section 371.2 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND DELEGATIONS OF AUTHORITY § 371.2 The Office of the Administrator. (a) The...

  5. 15 CFR 756.2 - Appeal from an administrative action.

    Science.gov (United States)

    2010-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS APPEALS... Industry and Security, U.S. Department of Commerce, Room 3898, 14th Street and Pennsylvania Avenue, NW... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeal from an administrative action...

  6. 24 CFR 125.201 - Administrative Enforcement Initiative.

    Science.gov (United States)

    2010-04-01

    ... Initiative. 125.201 Section 125.201 Housing and Urban Development Regulations Relating to Housing and Urban... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.201 Administrative Enforcement Initiative. The Administrative Enforcement Initiative provides funding to State and local fair housing agencies administering...

  7. 7 CFR 277.9 - Administrative costs principles.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administrative costs principles. 277.9 Section 277.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... AGENCIES § 277.9 Administrative costs principles. (a) This section prescribes specific policies and...

  8. MEXICAN ADMINISTRATIVE LAW AGAINST CORRUPTION: SCOPE AND FUTURE

    OpenAIRE

    Márquez, Daniel

    2016-01-01

    This work gives a synopsis of the evolution of public administration control mechanisms in Mexico. It highlights the instrumental nature of oversight, as well as regulatory and assessment aspects, and discusses issues like the historical design of the control instruments used in Mexican public administration. Certain social and political aspects from a legal perspective of administrative anti-corruption regulations are then underscored. The article concludes by drawing attention to the fact t...

  9. Properties of Commercial PVC Films with Respect to Electron Dosimetry

    DEFF Research Database (Denmark)

    Miller, Arne; Liqing, Xie

    The properties of three commercially available polyvinyl chloride (PVC) film supplies and one made without additives were tested with respect to their application as routine dose monitors at electron accelerators. Dose fractionation was found to increase the response and the post-irradiation heat...

  10. Consumer Behavior in respect of milk in The Netherlands

    NARCIS (Netherlands)

    J.G. Termorshuizen (Koos); M.T.G. Meulenberg; B. Wierenga (Berend)

    1986-01-01

    textabstractIn this paper, consumer behaviour in the Netherlands in respect of milk is investigated using a model based on the EKB model, a so-called integrated model of consumer behaviour. The objectives of the study are: to gain insight into the factors that influence buying and consumption

  11. Working together to build a respectful workplace: transforming OR culture.

    Science.gov (United States)

    Costello, Judy; Clarke, Cathy; Gravely, Gillian; D'Agostino-Rose, Dina; Puopolo, Rose

    2011-01-01

    Respect is important in the creation of a positive perioperative work environment and effective OR teams. Low scores for respect in the OR on an employee opinion survey and responses on a more customized survey that examined issues associated with respect prompted leaders at the University Health Network to undertake a multiyear organizational strategy to address respect and quality of worklife initiatives. An interprofessional quality of worklife task force convened to create an action plan to address the outcomes of the surveys. The work of the task force included developing and implementing a code of conduct team charter for the OR, empowering leaders to better manage conflict through education and coaching, creating a collaborative, consistent approach to conflict resolution, and designing an education strategy for staff members to enhance communication and conflict resolution. Results of recent employee opinion surveys have reflected positive outcomes. Efforts to sustain the effects of the project include quarterly recognition awards and ongoing education focused on wellness and communication skills. Copyright © 2011 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  12. Availability and traditional practice with respect to fodder trees and ...

    African Journals Online (AJOL)

    The paper reports a study that provided important information from farmers of the floodplain area of Bangladesh for setting research and development priorities with respect to indigenous and exotic fodder trees. Indigenous knowledge of fodder trees from the floodplain area may be an important tool in planning nutrition for ...

  13. Respective effects of sodium and chloride ion on physiological ...

    African Journals Online (AJOL)

    Respective effects of sodium and chloride ion on growth, cell morphological changes, membrane disorganization, ion homeostasis, exoenzyme activities and fermentation performance in Zymomonas mobilis232B cultures were presented. In batch cultures containing 0.15 M NaCl, Z. mobilis232B developed filaments, and ...

  14. Respecting Preferences : Gender Justice and the Normative Hierarchy View

    NARCIS (Netherlands)

    J. Kloeg (Julien)

    2013-01-01

    textabstractTheorists of justice have to steer between two rocks. On the one hand, there is the intuition that an individual’s morally permitted preferences should be respected: it is not justifiable to intervene with them. On the other hand, such preferences are the result of formation processes,

  15. WWER 440 integrity assessment with respect to PTS events

    International Nuclear Information System (INIS)

    Hrazsky, M.; Mikua, M.; Hermansky, P.

    1997-01-01

    The present state of art in WWER 440 RPV integrity assessment with respect to PTS events utilized in Slovakia is reviewed briefly in this paper. Recent results of some PTS's (very severe) analyses, shortly described in our paper, have confirmed the necessity of elaboration of new more sophisticated procedures again. Such methodology should be based on prepared IAEA Guidance. (author). 13 refs, 1 fig

  16. Basing Science Ethics on Respect for Human Dignity.

    Science.gov (United States)

    Aközer, Mehmet; Aközer, Emel

    2016-12-01

    A "no ethics" principle has long been prevalent in science and has demotivated deliberation on scientific ethics. This paper argues the following: (1) An understanding of a scientific "ethos" based on actual "value preferences" and "value repugnances" prevalent in the scientific community permits and demands critical accounts of the "no ethics" principle in science. (2) The roots of this principle may be traced to a repugnance of human dignity, which was instilled at a historical breaking point in the interrelation between science and ethics. This breaking point involved granting science the exclusive mandate to pass judgment on the life worth living. (3) By contrast, respect for human dignity, in its Kantian definition as "the absolute inner worth of being human," should be adopted as the basis to ground science ethics. (4) The pathway from this foundation to the articulation of an ethical duty specific to scientific practice, i.e., respect for objective truth, is charted by Karl Popper's discussion of the ethical principles that form the basis of science. This also permits an integrated account of the "external" and "internal" ethical problems in science. (5) Principles of the respect for human dignity and the respect for objective truth are also safeguards of epistemic integrity. Plain defiance of human dignity by genetic determinism has compromised integrity of claims to knowledge in behavioral genetics and other behavioral sciences. Disregard of the ethical principles that form the basis of science threatens epistemic integrity.

  17. Respectful maternity care in Ethiopian public health facilities

    NARCIS (Netherlands)

    Sheferaw, Ephrem D.; Bazant, Eva; Gibson, Hannah; Fenta, Hone B.; Ayalew, Firew; Belay, Tsigereda B.; Worku, Maria M.; Kebebu, Aelaf E.; Woldie, Sintayehu A.; Kim, Young-Mi; van den Akker, T.; Stekelenburg, Jelle

    2017-01-01

    Background: Disrespect and abuse of women during institutional childbirth services is one of the deterrents to utilization of maternity care services in Ethiopia and other low- and middle-income countries. This paper describes the prevalence of respectful maternity care (RMC) and mistreatment of

  18. On the harmonic starlike functions with respect to symmetric ...

    African Journals Online (AJOL)

    In the present paper, we introduce the notions of functions harmonic starlike with respect to symmetric, conjugate and symmetric conjugate points. Such results as coefficient inequalities and structural formulae for these function classes are proved. Keywords: Harmonic functions, harmonic starlike functions, symmetric points, ...

  19. Promoting Respect as a Human Value in a Public School

    Science.gov (United States)

    Corzo, Josefina Quintero; Castañeda, Yeisson Soto

    2017-01-01

    This is a case study report arising from a series of daily observations of the students' behavior made in a primary public school located near to the capital city, Manizales-Colombia, where it was possible to notice the difficulties students had in order to coexist due to the lack of respect with their classmates, in group activities or actually…

  20. Integration with respect to the Euler characteristic and its applications

    Energy Technology Data Exchange (ETDEWEB)

    Gusein-Zade, Sabir M [M. V. Lomonosov Moscow State University, Moscow (Russian Federation)

    2010-09-16

    The notion of integration with respect to the Euler characteristic and its generalizations are discussed: integration over the infinite-dimensional spaces of arcs and functions, motivic integration. The author describes applications of these notions to the computation of monodromy zeta functions, Poincare series of multi-index filtrations, generating series of classes of certain moduli spaces, and so on. Bibliography: 70 titles.

  1. 48 CFR 619.402 - Small Business Administration procurement center representatives.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Small Business... DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Cooperation with the Small Business Administration 619.402 Small Business Administration procurement center representatives. ...

  2. 75 FR 69080 - Federal Travel Regulation (FTR)

    Science.gov (United States)

    2010-11-10

    ... Administration (GSA) has issued FTR Bulletin 11-02, updating the Fly America Act information on the GSA web site... GENERAL SERVICES ADMINISTRATION Federal Travel Regulation (FTR) Fly America Act; United States and... Governmentwide Policy, General Services Administration (GSA). [[Page 69081

  3. Development of nuclear power with respect to water management

    International Nuclear Information System (INIS)

    Plainer, J.

    1982-01-01

    Discussed are the siting of nuclear power plants, the cooling of nuclear power plants, the environmental impacts of radioactive wastes and the provision of drinking water for nuclear power plant personnel. A power plant with a maximum capacity of 4x1000 MW is envisaged for any selected site. The cooling concept is based on water recirculation and the use of cooling towers. The envisaged need of cooling water is 0.9 to 1.3 l/s per 1 MW of power; non-recoverable water consumption is estimated at 0.7 to 1.0 l/s per 1 MW of power. The discharge of tritiated water and sewage water into surface waters is regulated by laws and regulations issued by the government of the Czech Socialist Republic. However, value criteria have not been determined for assessing the toxicity of radioactive substances for aquatic organisms and for disturbing the self-cleaning ability of water courses. For solid radioactive waste disposal the water management authority may set conditions with regard to local water conditions. The drinking water supply must be designed with regard to local conditions. The drinking water need is planned within the range of 5 to 10 l/s, in peak hours at 10 to 30 l/s. (J.P.)

  4. Educational Administration's Weber.

    Science.gov (United States)

    Gronn, Peter

    1994-01-01

    Discusses Max Weber's importance in Greenfield's work, particularly in Greenfield and Ribbins'"Greenfield on Educational Administration" (1993). In concentrating on human actors' subjective understanding, Greenfield was a faithful Weberian. However, he deviated from Weber by disavowing structural explanations of social and organizational…

  5. Tax administration good governance

    NARCIS (Netherlands)

    Végh, Gyöngyi; Gribnau, Hans

    2018-01-01

    There is no doubt that tax administration is a complex matter. It is institutionalised by a governance framework which is strongly influenced by legal traditions, state governance approaches, historical developments, and norms and values of society. While there are many common aspects of national

  6. Ethics in Public Administration

    Directory of Open Access Journals (Sweden)

    MSc. Arjeta Hallunovi

    2014-06-01

    Full Text Available The goal of this study is to deal with some ethical causes in the public administration, that aim the avoidance of negative phenomenon’s as theft, corruption, etc. In this direction, the debates about ethics are becoming more and more a global tendency, as an implement through which would be found the way to get out of the crisis. The success in the reforms of the public administrations in major part depends, on the public functionaries and their willingness to make fundamental changes in the way they work. In this direction, the State should strengthen and modernize the public service, should realize an employment system, which should reflect more the merits on its service. For this reason, the government’s attempts should be concentrated on the construction of a positive image for the state and its administration as professional objective, which is oriented to the services. Being aware for the practical restrictions of this study, we firstly chose to concentrate on the local public administrations ethics. The study will be focused on the practical comparative analysis of the city of Shkodra and Durres by the realization of a questionnaire by each of these municipalities and the Agency of Legalization and Urbanization of Informal Zones (ALUIZNI in Shkodra.

  7. Hospital Library Administration.

    Science.gov (United States)

    Cramer, Anne

    The objectives of a hospital are to improve patient care, while the objectives of a hospital library are to improve services to the staff which will support their efforts. This handbook dealing with hospital administration is designed to aid the librarian in either implementing a hospital library, or improving services in an existing medical…

  8. Enterprise Mac administrators guide

    CERN Document Server

    Smith, William

    2015-01-01

    IT departments everywhere will be integrating Macs and Mac OS X into their IT infrastructure and this book will tell them how to do it. It will serve as an authoritative, useful and frequently referenced book on Mac OS X administration.

  9. Administrative circular No. 12

    CERN Document Server

    HR Department

    2006-01-01

    On the recommendation of the Standing Concertation Committee, the Director-General has approved the amounts used for the reimbursements mentioned in Administrative Circular No. 12 as follows: The figures, effective from 1 September 2006, are: Paragraph 8a: 17 Swiss francs Paragraph 9a: 682 Swiss francs Paragraph 9b: 34 Swiss francs Human Resources Department Tel. 79257/72862

  10. A Treatise on Administration.

    Science.gov (United States)

    Moore, Thomas R.

    1988-01-01

    Expands Henri Fayol's definition of the administrative process to include a humanistic approach involving planning, organizing, implementing, controlling, evaluating, and satisfying functions. This empirical definition differs from some theoretical approaches by looking beyond resource consumption to consider ecological effects on the environment…

  11. Administrators Confront Student "Sexting"

    Science.gov (United States)

    Manzo, Kathleen Kennedy

    2009-01-01

    Cellphone-savvy students have created instructional and disciplinary challenges for educators for years. But the recent emergence of "sexting" by adolescents over their mobile phones caught many school administrators off guard, and the practice is prompting efforts around the country to craft policy responses. Students' sharing of nude or…

  12. Refinement for administrative policies

    NARCIS (Netherlands)

    Dekker, M.A.C.; Etalle, S.; Jonker, W.; Petkovic, M.

    2007-01-01

    Flexibility of management is an important requisite for access control systems as it allows users to adapt the access control system in accordance with practical requirements. This paper builds on earlier work where we defined administrative policies for a general class of RBAC models. We present a

  13. 76 FR 11071 - Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority...

    Science.gov (United States)

    2011-02-28

    ...--Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority Relating to the... Respect to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of... north of Cuba. On February 26, 2004, by Proclamation 7757, the national emergency was extended and its...

  14. 78 FR 13207 - Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority...

    Science.gov (United States)

    2013-02-26

    ...--Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority Relating to the... Respect to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of... north of Cuba. On February 26, 2004, by Proclamation 7757, the national emergency was extended and its...

  15. Autonomy, Respect, and Arrogance in the Danish Cartoon Controversy

    DEFF Research Database (Denmark)

    Rostbøll, Christian F.

    2009-01-01

    is understood as something we should presume everyone possesses, it provides a strong basis for equal respect among people from diverse cultures. A Kantian conception of autonomy can justify the right to freedom of expression while it at the same time requires that we in the exercise of freedom of expression......Autonomy is increasingly rejected as a fundamental principle by liberal political theorists, because it is regarded as incompatible with respect for diversity. This article seeks, via an analysis of the Danish cartoon controversy, to show that the relationship between autonomy and diversity is more...... complex than often posited. Particularly, it asks whether the autonomy defense of freedom of expression encourages disrespect for religious feelings. Autonomy leads to disrespect for diversity only when it is understood as a character ideal that must be promoted as an end in itself. If it by contrast...

  16. Autonomy and the principle of respect for autonomy.

    Science.gov (United States)

    Gillon, R

    1985-06-15

    Autonomy is defined as the capacity to think, decide, and act freely and independently on the basis of such thought and decisions. Three types of autonomy are distinguished: autonomy of thought, which embraces the wide range of human intellectual activities called "thinking for oneself"; autonomy of will, or the capacity to decide to do things on the basis of one's deliberations; and autonomy of action, the absence of which is illustrated by the situation of a patient whose voluntary muscles are paralyzed by curariform drugs and who thus cannot tell the surgeon that the anesthetist has forgotten the nitrous oxide. Autonomy is viewed as a prerequisite for all the virtues, rather than as a virtue in its own right. The arguments of Immanuel Kant and John Stuart Mill concerning the principle of respect for autonomy are summarized as exemplars respectively of the deontological and utilitarian philosophical approaches.

  17. Teaching about Respect and Tolerance with Presentations on Cultural Values

    Directory of Open Access Journals (Sweden)

    Hamdi Serin

    2017-06-01

    Full Text Available Teaching students from diverse backgrounds requires more than sufficient. Very often battles occur among students due to not understanding each other’s values. This study presents experience of a teacher who teaches students from diverse religious, ethnic, and cultural groups. As disrespect, misunderstanding and intolerance were common in the class, it was difficult for the teacher to advance respect among the students for diversity. In order to encourage the students to embrace diversity, the teacher made them introduce their cultures through presentations in the classroom. Although at the beginning the students continued to tease each other by making fun of each other’s cultural values, after some time it was discovered that they were entering the classroom with a real respect and tolerance for diversity.

  18. New forms of -compactness with respect to hereditary classes

    Directory of Open Access Journals (Sweden)

    Abdo Mohammed Qahis

    2019-01-01

    Full Text Available A hereditary class on a set X is a nonempty collection of subsets closed under heredity. The aim of this paper is to introduce and study strong forms of u-compactness in generalized topological spaces with respect to a hereditary class, called  SuH-compactness and S- SuH-compactness. Also several of their properties are presented. Finally some eects of various kinds of functions on them are studied.

  19. Autonomy, Respect, and Arrogance in the Danish Cartoon Controversy

    OpenAIRE

    Rostbøll, Christian F.

    2009-01-01

    Udgivelsesdato: 2009 Autonomy is increasingly rejected as a fundamental principle by liberal political theorists, because it is regarded as incompatible with respect for diversity. This article seeks, via an analysis of the Danish cartoon controversy, to show that the relationship between autonomy and diversity is more complex than often posited. Particularly, it asks whether the autonomy defense of freedom of expression encourages disrespect for religious feelings. Autonomy leads to disre...

  20. Calibration of an Aethalometer with Respect to Varying Humidities

    Energy Technology Data Exchange (ETDEWEB)

    Hannemann, A.; Weingartner, E.; Saathoff, H. [FZ Karlsruhe (Georgia); Schnalter, M. [FZ Karlsruhe (Georgia); Baltensperger, U.

    2004-03-01

    The determination of the light absorption coefficient of the atmospheric aerosol is important with respect to its climate forcing. Measurements of b{sub abs} by means of filter based absorption techniques (e.g. with aethalometers) require to correct for artefacts from condensable gases. Otherwise derived absorption coefficients may be too high, leading to an underestimation of climate relevant parameters such as the single scattering albedo. The corrections presented here enhance the accuracy of aethalometer datasets. (author)

  1. Selectivity of Black Death mortality with respect to preexisting health

    OpenAIRE

    DeWitte, Sharon N.; Wood, James W.

    2008-01-01

    Was the mortality associated with the deadliest known epidemic in human history, the Black Death of 1347–1351, selective with respect to preexisting health conditions (“frailty”)? Many researchers have assumed that the Black Death was so virulent, and the European population so immunologically naïve, that the epidemic killed indiscriminately, irrespective of age, sex, or frailty. If this were true, Black Death cemeteries would provide unbiased cross-sections of demographic and epidemiological...

  2. Raising students’ awareness with respect to choice of literature

    DEFF Research Database (Denmark)

    Bagger, Bettan; Taylor Kelly, Hélène; Hørdam, Britta

    is a pedagogical tool which raises students’ awareness with respect to the necessity of employing scientific and researched based material. The tool is not only used in the theoretical setting but also in clinical practice. Students and clinical advisors evaluate the relevance of the pedagogical tool via...... questionnaires. The data will be analyzed and form the basis for further innovative teaching developments promoting the theory-clinical connection in the learning environment. Keywords: literature, education, pedagogical tool, theory-practice connection....

  3. WWER 440 integrity assessment with respect to PTS events

    Energy Technology Data Exchange (ETDEWEB)

    Hrazsky, M; Mikua, M; Hermansky, P [Nuclear Power Plant Research Inst. Trnava Inc., Trnava (Slovakia)

    1997-09-01

    The present state of art in WWER 440 RPV integrity assessment with respect to PTS events utilized in Slovakia is reviewed briefly in this paper. Recent results of some PTS`s (very severe) analyses, shortly described in our paper, have confirmed the necessity of elaboration of new more sophisticated procedures again. Such methodology should be based on prepared IAEA Guidance. (author). 13 refs, 1 fig.

  4. Teaching ethics: when respect for autonomy and cultural sensitivity collide.

    Science.gov (United States)

    Minkoff, Howard

    2014-04-01

    Respect for autonomy is a key ethical principle. However, in some cultures other moral domains such as community (emphasizing the importance of family roles) and sanctity (emphasizing the sacred and the spiritual side of human nature) hold equal value. Thus, an American physician may sometimes perceive a conflict between the desire to practice ethically and the wish to be sensitive to the mores of other cultures. For example, a woman may appear to be making what the physician thinks is a bad clinical choice because her spouse is speaking on her behalf. That physician may find it difficult to reconcile the sense that the patient had not exercised freely her autonomy with the desire to be culturally sensitive. In this article, the means by which a physician can reconcile respect for other cultures with respect for autonomy is explored. The question of whether physicians must always defer to patients' requests solely because they are couched in the language of cultural sensitivity is also addressed. Copyright © 2014 Mosby, Inc. All rights reserved.

  5. The brazilian nuclear policy with respect to the public opinion

    International Nuclear Information System (INIS)

    Freitas Brandao Bittencourt, C.

    1988-01-01

    Four decades of the Brazilian nuclear history have been analysed with special emphasis placed on government policy and its repercussion on public opinion. The implications of the new constitutional regulations which rule the issue are discussed. it is also studied the change in the nuclear program structure, enforced in August 1988. At different times, the government decisions on nuclear energy could be classified as miser, extravagant, dissimulated and frank, successively. Their aftermaths, which show little consistency with the expectations laid on them, have led to discredit by part of the society, which is controlled by a scientific - intellectual elite. However, recent successes are likely to reverse this trend, if the government explores them properly. (author) [pt

  6. RNA and Proteins: Mutual Respect [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Kathleen B. Hall

    2017-03-01

    Full Text Available Proteins and RNA are often found in ribonucleoprotein particles (RNPs, where they function in cellular processes to synthesize proteins (the ribosome, chemically modify RNAs (small nucleolar RNPs, splice pre-mRNAs (the spliceosome, and, on a larger scale, sequester RNAs, degrade them, or process them (P bodies, Cajal bodies, and nucleoli. Each RNA–protein interaction is a story in itself, as both molecules can change conformation, compete for binding sites, and regulate cellular functions. Recent studies of Xist long non-coding RNP, the U4/5/6 tri-small nuclear RNP complex, and an activated state of a spliceosome reveal new features of RNA interactions with proteins, and, although their stories are incomplete, they are already fascinating.

  7. Humility and respect: core values in medical education.

    Science.gov (United States)

    Gruppen, Larry D

    2014-01-01

    Many of the values and behaviours described in the original Hippocratic Oath are relevant to medical education. In particular, the values of intellectual humility and respect for one's colleagues are essential in all scientific disciplines. There are three contexts within medical education from which to consider humility and respect: uncertainty; theory, and colleagues. As medical education grows in scope and participation, we will be required to acknowledge that we 'know not' with increasing frequency. The uncertainty of what we do and do not know is compounded by uncertainty about whether ignorance is individual or corporate. As difficult as it is to admit that we 'know not', it is dangerous NOT to recognise the limits of our knowledge and experience. Theories are critical tools in understanding complex phenomena. They identify constructs and relationships that are important and those that are irrelevant. We tend to forget that theories are models or simplified representations of reality and not in themselves 'truths'. Viewing problems from other theoretical perspectives can widen our horizons by allowing us to identify possibly important concepts and relationships that we have not considered. Colleagues are invaluable for helping us respond to our 'knowing not' and for providing alternative perspectives when our theories lead us astray. However, colleagues come in many guises and include close colleagues, as well as those in distant fields. As obviously desirable as humility and respect seem to be, there are conflicts that prevent us from being humble and respectful. Such conflicts include other salient professional values, such as critical scepticism, competition and confidence. Adoption of the values of humility and respect in medical education can be fostered through intentional behaviours, both as individuals and as a discipline. We can deliberately seek to broaden our horizons to promote intellectual humility. We can foster collaboration among colleagues

  8. 20 CFR 416.1020 - General administrative requirements.

    Science.gov (United States)

    2010-04-01

    ... cause the State to be substantially failing to comply with our regulations or other written guidelines... substantially failing to follow our regulations or other written guidelines. (b) The State is responsible for... Section 416.1020 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE...

  9. 20 CFR 404.1620 - General administrative requirements.

    Science.gov (United States)

    2010-04-01

    ... cause the State to be substantially failing to comply with our regulations or other written guidelines... substantially failing to follow our regulations or other written guidelines. (b) The State is responsible for... Section 404.1620 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND...

  10. 15 CFR 785.3 - Initiation of administrative proceedings.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Initiation of administrative proceedings. 785.3 Section 785.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS...

  11. 7 CFR 1001.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1001.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE NORTHEAST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1001.85...

  12. 7 CFR 1033.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1033.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE MIDEAST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1033.85...

  13. 7 CFR 1032.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1032.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE CENTRAL MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1032.85...

  14. 7 CFR 1126.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1126.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHWEST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1126.85...

  15. 7 CFR 1124.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1124.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE PACIFIC NORTHWEST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1124.85...

  16. 7 CFR 1006.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1006.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE FLORIDA MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1006.85...

  17. 7 CFR 1007.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1007.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHEAST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1007.85...

  18. 7 CFR 1131.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1131.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE ARIZONA MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1131.85...

  19. 7 CFR 1005.85 - Assessment for order administration.

    Science.gov (United States)

    2010-01-01

    ... 1005.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE APPALACHIAN MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction § 1005.85...

  20. 29 CFR 502.37 - Referral to Administrative Law Judge.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Referral to Administrative Law Judge. 502.37 Section 502.37 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF...