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Sample records for regulations air bags

  1. 49 CFR 173.166 - Air bag inflators, air bag modules and seat-belt pretensioners.

    Science.gov (United States)

    2010-10-01

    ... generant and, in some cases, a pressure vessel (cylinder)) is a gas generator used to inflate an air bag in... domestic transportation by highway, rail freight, cargo vessel or cargo aircraft, a serviceable air bag...

  2. Development and functional significance of dorsal air bags in ...

    African Journals Online (AJOL)

    This study describes the morphology and investigates the possible function of the air bags found on the nestlings of Monteiro's Hornbill Tockus monteiri. These air bags increased in size with age and mass of the nestling until 14 d of age, and then decreased in size. By 20 d of age, the air bags were absent. Histological ...

  3. Wave energy absorption by a floating air bag

    DEFF Research Database (Denmark)

    Kurniawan, Adi; Chaplin, John; Greaves, Deborah

    2017-01-01

    A floating air bag, ballasted in water, expands and contracts as it heaves under wave action. Connecting the bag to a secondary volume via a turbine transforms the bag into a device capable of generating useful energy from the waves. Small-scale measurements of the device reveal some interesting...

  4. Development and functional significance of dorsal air bags in ...

    African Journals Online (AJOL)

    Histological examination of the air bags showed that they were integumentary structures composed of an outer epidermis and an inner dermis. The air bags were not connected to the respiratory system. The body temperature (Tb) of Monteiro's Hornbill nestlings increased significantly with increasing age. Comparisons of ...

  5. Air Bag Momentum Force Including Aspiration

    Directory of Open Access Journals (Sweden)

    Guy Nusholtz

    1995-01-01

    Full Text Available A gas-jet momentum force drives the air bag into position during a crash. The magnitude of this force can change as a result of aspiration. To determine the potential magnitude of the effect on the momentum force and mass flow rate in an aspirated system, a series of experiments and simulations of those experiments was conducted. The simulation consists of a two-dimensional unsteady isentropic CFD model with special “infinite boundaries”. One of the difficulties in simulating the gas-jet behavior is determining the mass flow rate. To improve the reliability of the mass flow rate input to the simulation, a sampling procedure involving multiple tests was used, and an average of the tests was adopted.

  6. Wave energy absorption by a submerged air bag connected to a rigid float

    DEFF Research Database (Denmark)

    Kurniawan, Adi; Chaplin, J. R.; Hann, M. R.

    2017-01-01

    A new wave energy device features a submerged ballasted air bag connected at the top to a rigid float. Under wave action, the bag expands and contracts, creating a reciprocating air flow through a turbine between the bag and another volume housed within the float. Laboratory measurements are gene......A new wave energy device features a submerged ballasted air bag connected at the top to a rigid float. Under wave action, the bag expands and contracts, creating a reciprocating air flow through a turbine between the bag and another volume housed within the float. Laboratory measurements...

  7. BAG3 controls angiogenesis through regulation of ERK phosphorylation.

    Science.gov (United States)

    Falco, A; Festa, M; Basile, A; Rosati, A; Pascale, M; Florenzano, F; Nori, S L; Nicolin, V; Di Benedetto, M; Vecchione, M L; Arra, C; Barbieri, A; De Laurenzi, V; Turco, M C

    2012-12-13

    BAG3 is a co-chaperone of the heat shock protein (Hsp) 70, is expressed in many cell types upon cell stress, however, its expression is constitutive in many tumours. We and others have previously shown that in neoplastic cells BAG3 exerts an anti-apoptotic function thus favoring tumour progression. As a consequence we have proposed BAG3 as a target of antineoplastic therapies. Here we identify a novel role for BAG3 in regulation of neo-angiogenesis and show that its downregulation results in reduced angiogenesis therefore expanding the role of BAG3 as a therapeutical target. In brief we show that BAG3 is expressed in endothelial cells and is essential for the interaction between ERK and its phosphatase DUSP6, as a consequence its removal results in reduced binding of DUSP6 to ERK and sustained ERK phosphorylation that in turn determines increased levels of p21 and p15 and cell-cycle arrest in the G1 phase.

  8. [A new applicator with regulatable air bag designed for intracavitary brachytherapy of nasopharyngeal carcinoma].

    Science.gov (United States)

    Zhang, Ning; Wei, Guang-Yu; Tan, Yi-Chang; Huang, Ze-Li; Li, Shao-En; Lu, Zhi-Qian

    2004-10-01

    Nasopharynx applicator used in intracavitary brachytherapy plays an important role in the radiotherapy of nasopharyngeal carcinoma (NPC), its quality affects the efficiency of treatment. This study was to design a new applicator for clinical use. An inexpensive, reusable, and flexible latex nasopharynx applicator was designed. An air bag was placed at 15 mm from the foreside of the applicator, clung to the tube. The edge of air bag is tangent to the axis of tube. When the bag was full of air, the tube would hunch reversely,close to nasopharyngeal vault. After introduced into nasopharynx through middle nasal meatus, the applicator could be fixed in suitable position by its rotation, and air bag regulation, and confirmed its position by simulation. A total of 221 patients with NPC were treated with external beam radiation therapy in our hospital, and boosted HDR brachytherapy using this new applicator. The response rate was 92.6% in the primary tumor group (200/216), and 100% in the recurrent tumor group (5/5). Mucosal necrosis in the posterior or anterior wall of nasopharynx occurred in 5 patients, 8 patients experienced nasal congestion and nasal synechia. This new nasopharynx applicator is easy to operate, painless, and well dosage-distributed. Mucosal necrosis is likely due to higher fractional dose.

  9. Commercial liquid bags as a potential source of venous air embolism in shoulder arthroscopy.

    Science.gov (United States)

    Austin, Luke; Zmistowski, Benjamin; Tucker, Bradford; Hetrick, Robin; Curry, Patrick; Williams, Gerald

    2010-09-01

    Venous air embolism is a rare but potentially fatal complication of arthroscopy. Fatal venous air embolism has been reported with as little as 100 mL of air entering the venous system. During liquid-only arthroscopy, avenues for air introduction into the joint are limited. Therefore, we hypothesized that commercially prepared 3-L saline-solution bags are a source of potentially fatal amounts of gas that can be introduced into the joint by arthroscopic pumps. Eight 3-L arthroscopic saline-solution bags were obtained and visually inspected for air. The air was aspirated from four bags, and the volume of the air was recorded. A closed-system pump was prepared, and two 3-L bags were connected to it. The pump emptied into an inverted graduated cylinder immersed in a water bath. Both bags were allowed to run dry. Two more bags were then connected and also allowed to run dry. The air was quantified by the downward displacement of water. The experiment was then repeated with the four bags after the air had been aspirated from them. This experiment was performed at three institutions, with utilization of three pump systems and two brands of 3-L saline-solution bags. Air was visualized in all bags, and the bags contained between 34 and 85 mL of air. Arthroscopic pumps can pump air efficiently through the tubing. The total volumes of gas ejected from the tubing after the four 3-L bags had been emptied were 75, 80, and 235 mL. When bags from which the air had been evacuated were used, no air exited the system. Because a saline-solution arthroscopic pump is theoretically a closed system, venous air embolism has not been a concern. However, this study shows that it is possible to pump a fatal amount of air from 3-L saline-solution bags into an environment susceptible to the creation of emboli. Evacuation of air from the 3-L bags prior to use may eliminate this risk.

  10. Prediction of air temperature for thermal comfort of people using sleeping bags: a review.

    Science.gov (United States)

    Huang, Jianhua

    2008-11-01

    Six models for determining air temperatures for thermal comfort of people using sleeping bags were reviewed. These models were based on distinctive metabolic rates and mean skin temperatures. All model predictions of air temperatures are low when the insulation values of the sleeping bag are high. Nevertheless, prediction variations are greatest for the sleeping bags with high insulation values, and there is a high risk of hypothermia if an inappropriate sleeping bag is chosen for the intended conditions of use. There is, therefore, a pressing need to validate the models by wear trial and determine which one best reflects ordinary consumer needs.

  11. BAG3: a multifaceted protein that regulates major cell pathways

    Science.gov (United States)

    Rosati, A; Graziano, V; De Laurenzi, V; Pascale, M; Turco, M C

    2011-01-01

    Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through BAG domain (110–124 amino acids). BAG3 is the only member of the family to be induced by stressful stimuli, mainly through the activity of heat shock factor 1 on bag3 gene promoter. In addition to the BAG domain, BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70. These multifaceted interactions underlie BAG3 ability to modulate major biological processes, that is, apoptosis, development, cytoskeleton organization and autophagy, thereby mediating cell adaptive responses to stressful stimuli. In normal cells, BAG3 is constitutively present in a very few cell types, including cardiomyocytes and skeletal muscle cells, in which the protein appears to contribute to cell resistance to mechanical stress. A growing body of evidence indicate that BAG3 is instead expressed in several tumor types. In different tumor contexts, BAG3 protein was reported to sustain cell survival, resistance to therapy, and/or motility and metastatization. In some tumor types, down-modulation of BAG3 levels was shown, as a proof-of-principle, to inhibit neoplastic cell growth in animal models. This review attempts to outline the emerging mechanisms that can underlie some of the biological activities of the protein, focusing on implications in tumor progression. PMID:21472004

  12. A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.

    Science.gov (United States)

    Cao, Yu-Lan; Yang, Ya-Ping; Mao, Cheng-Jie; Zhang, Xiao-Qi; Wang, Chen-Tao; Yang, Jing; Lv, Dong-Jun; Wang, Fen; Hu, Li-Fang; Liu, Chun-Feng

    2017-12-01

    Many studies reveal that BAG3 plays a critical role in the regulation of protein degradation via macroautophagy. However, it remains unknown whether BAG3 affects the quality control of α-synuclein (SNCA), a Parkinson's disease-related protein. In this study, we demonstrated the increases of BAG3 expression in the ventral midbrain of SNCA A53T transgenic mice and also in MG132-treated PC12 cells overexpressing wild-type SNCA (SNCA WT -PC12). Moreover, we showed that BAG3 overexpression was sufficient to enhance the autophagy activity while knockdown of Bag3 reduced it in SNCA WT -PC12 cells. Immunoprecipitation revealed that BAG3 interacted with heat shock protein 70 and sequestosome 1. The immunostaining also showed the perinuclear accumulation and colocalization of BAG3 with these 2 proteins, as well as with LC3 dots in tyrosine hydroxylase-positive neurons in the midbrain of SNCA A53T mice. BAG3 overexpression was able to modulate SNCA degradation via macroautophagy which was prevented by Atg5 knockdown. Taken together, these results indicate that BAG3 plays a relevant role in regulating SNCA clearance via macroautophagy, and the heat shock protein 70-BAG3-sequestosome 1 complex may be involved in this process. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Vented spikes improve delivery from intravenous bags with no air headspace.

    Science.gov (United States)

    Galush, William J; Horst, Travis A

    2015-07-01

    Flexible plastic bags are the container of choice for most intravenous (i.v.) infusions. Under certain circumstances, however, the air-liquid interface present in these i.v. bags can lead to physical instability of protein biopharmaceuticals, resulting in product aggregation. In principle, the air headspace present in the bags can be removed to increase drug stability, but experiments described here show that this can result in incomplete draining of solution from the bag using gravity delivery, or generation of negative pressure in the bag when an infusion pump is used. It is expected that these issues could lead to incomplete delivery of medication to patients or pump-related problems, respectively. However, here it is shown that contrary to the standard pharmacy practice of using nonvented spikes with i.v. bags, the use of vented spikes with i.v. bags that lack air headspace allows complete delivery of the dose solution without impacting the physical stability of a protein-based drug. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

  14. Protection against head injuries should not be optional: a case for mandatory installation of side-curtain air bags.

    Science.gov (United States)

    Stuke, Lance E; Nirula, Raminder; Gentilello, Larry M; Shafi, Shahid

    2010-10-01

    More than 9,000 vehicle occupants die each year in side-impact vehicle collisions, primarily from head injuries. The authors hypothesized that side-curtain air bags significantly improve head and neck safety in side-impact crash testing. Side-impact crash-test data were obtained from the Insurance Institute for Highway Safety, which ranks occupant protection as good, acceptable, marginal, or poor. Vehicles of the same make and model that underwent side-impact crash testing both with and without side-curtain air bags were compared, as well as the protective effect of these air bags on occupants' risk for head and neck injury. Of all the passenger vehicles, 25 models have undergone side-impact crash testing with and without side-curtain air bags by the Insurance Institute for Highway Safety. Only 3 models without side-curtain air bags (12%) provided good head and neck protection for drivers, while 21 cars with side-curtain air bags (84%) provided good protection (P bags was less dramatic but significant (84% without vs 100% with side-curtain air bags, P = .04). Side-curtain air bags significantly improve vehicle occupant safety in side-impact crash tests. Installation of these air bags should be federally mandated in all passenger vehicles. Copyright © 2010 Elsevier Inc. All rights reserved.

  15. Wave energy absorption by a submerged air bag connected to a rigid float.

    Science.gov (United States)

    Kurniawan, A; Chaplin, J R; Hann, M R; Greaves, D M; Farley, F J M

    2017-04-01

    A new wave energy device features a submerged ballasted air bag connected at the top to a rigid float. Under wave action, the bag expands and contracts, creating a reciprocating air flow through a turbine between the bag and another volume housed within the float. Laboratory measurements are generally in good agreement with numerical predictions. Both show that the trajectory of possible combinations of pressure and elevation at which the device is in static equilibrium takes the shape of an S. This means that statically the device can have three different draughts, and correspondingly three different bag shapes, for the same pressure. The behaviour in waves depends on where the mean pressure-elevation condition is on the static trajectory. The captured power is highest for a mean condition on the middle section.

  16. BAG3 regulates cell proliferation, migration, and invasion in human colorectal cancer.

    Science.gov (United States)

    Shi, Huiyong; Xu, Haidong; Li, Zengjun; Zhen, Yanan; Wang, Bin; Huo, Shoujun; Xiao, Ruixue; Xu, Zhongfa

    2016-04-01

    Bcl2-associated athanogene 3 (BAG3) has been reported to be elevated in various tumors. However, it is unclear whether BAG3 has a functional role in the initiation and progression of colorectal cancer (CRC). Here, we collected CRC samples and cell lines to validate the pathway by using gene and protein assays. RT-PCR showed that the expression of BAG3 mRNA in CRC tissues was obviously higher than that in non-tumor tissues (p BAG3 was found in most CRC tissues and strongly correlated with TNM stage (p = 0.001), differentiation (p = 0.003), and metastasis (p = 0.010). Low expression of BAG3 in HCT-8 significantly reduced cellular proliferation, migration, and invasion. The analysis of in vitro cell showed that HCT-8 cells were exposed to si-BAG3, and its growth was inhibited depending on modulation of cell cycle G1/S checkpoints and cell cycle regulators, involving cyclin D1, cyclin A2, and cyclin B1. Furthermore, suppression of the epithelial-mesenchymal transition (EMT) by si-BAG3 is linked to the decreased expression of E-cadherin and the increased expression of N-cadherin, vimentin, and MMP9. In conclusion, in the present study, we demonstrated that BAG3 overexpression plays a critical role in cell proliferation, migration, and invasion of colorectal cancer. Our data suggests targeted inhibition of BAG3 may be useful for patients with CRC.

  17. BAG3 regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma.

    Science.gov (United States)

    Xiao, Heng; Cheng, Shaobing; Tong, Rongliang; Lv, Zheng; Ding, Chaofeng; Du, Chengli; Xie, Haiyang; Zhou, Lin; Wu, Jian; Zheng, Shusen

    2014-03-01

    Bcl2-associated athanogene 3 (BAG3) protein is a co-chaperone of heat-shock protein (Hsp) 70 and may regulate major physiological and pathophysiological processes. However, few reports have examined the role of BAG3 in human hepatocellular carcinoma (HCC). In this study, we show that BAG3 regulates epithelial-mesenchymal transition (EMT) and angiogenesis in HCC. BAG3 was overexpressed in HCC tissues and cell lines. BAG3 knockdown resulted in reduction in migration and invasion of HCC cells, which was linked to reversion of EMT by increasing E-cadherin expression and decreasing N-cadherin, vimentin and slug expression, as well as suppressing matrix metalloproteinase 2 (MMP-2) expression. In a xenograft tumorigenicity model, BAG3 knockdown effectively inhibited tumor growth and metastasis through reduction in CD34 and VEGF expression and reversal of the EMT pathway. In conclusion, BAG3 is associated with the invasiveness and angiogenesis in HCC, and the BAG3 gene may be a novel therapeutic approach against HCC.

  18. Preliminary enviromagnetic comparison of the moss, lichen, and filter fabric bags to air pollution monitoring

    Directory of Open Access Journals (Sweden)

    Hanna Salo

    2014-08-01

    Full Text Available Air quality and anthropogenic air pollutants are usually investigated by passive biomonitoring which utilizes native species. Active biomonitoring, instead, refers to the use of transplants or bags in areas lacking native species. In Finland, the standardized moss bag technique SFS 5794 is commonly applied in active monitoring but there is still need for simpler and labor-saving sample material even on international scale. This article focuses on a preliminary comparison of the usability and collection efficiency of bags made of moss Sphagnum papillosum, lichen Hypogymnia physodes, and filter fabric (Filtrete™ in active biomonitoring of air pollutants around an industrial site in Harjavalta, SW Finland. The samples are analyzed with magnetic (i.e. magnetic susceptibility, isothermal remanent magnetization, hysteresis loop and hysteresis parameters methods highly suitable as a first-step tool for pollution studies. The results show that the highest magnetic susceptibility of each sample material is measured close to the industrial site. Furthermore, moss bags accumulate more magnetic material than lichen bags which, on the contrary, perform better at further distances. Filter fabric bags are tested only at 1 km sites indicating a good accumulation capability near the source. Pseudo-single-domain (PSD magnetite is identified as the main magnetic mineral in all sample materials and good correlations are found between different bag types. To conclude, all three materials effectively accumulate air pollutants and are suitable for air quality studies. The results of this article provide a base for later studies which are needed in order to fully determine a new, efficient, and easy sample material for active monitoring.

  19. From macro- to microplastics - Analysis of EU regulation along the life cycle of plastic bags

    DEFF Research Database (Denmark)

    Steensgaard, Ida M; Syberg, Kristian; Rist, Sinja

    2017-01-01

    Plastic pollution and its environmental effects has received global attention the recent years. However, limited attention has so far been directed towards how plastics are regulated in a life cycle perspective and how regulatory gaps can be addressed in order to limit and prevent environmental...... exposure and hazards of macro- and microplastics. In this paper, we map European regulation taking outset in the life cycle perspective of plastic carrier bags: from plastic bag production to when it enters the environment. Relevant regulatory frameworks, directives and authorities along the life cycle...... are identified and their role in regulation of plastics is discussed. Most important regulations were identified as: the EU chemical Regulation, the Packaging and Packaging Waste Directive including the amending Directive regarding regulation of the consumption of lightweight plastic carrier bags, the Waste...

  20. Hsp70-Bag3 interactions regulate cancer-related signaling networks.

    Science.gov (United States)

    Colvin, Teresa A; Gabai, Vladimir L; Gong, Jianlin; Calderwood, Stuart K; Li, Hu; Gummuluru, Suryaram; Matchuk, Olga N; Smirnova, Svetlana G; Orlova, Nina V; Zamulaeva, Irina A; Garcia-Marcos, Mikel; Li, Xiaokai; Young, Z T; Rauch, Jennifer N; Gestwicki, Jason E; Takayama, Shinichi; Sherman, Michael Y

    2014-09-01

    Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp70 on Src signaling. Using several complementary approaches, we established that the Hsp70-Bag3 module is a broad-acting regulator of cancer cell signaling by modulating the activity of the transcription factors NF-κB, FoxM1, Hif1α, the translation regulator HuR, and the cell-cycle regulators p21 and survivin. We also identified a small-molecule inhibitor, YM-1, that disrupts the Hsp70-Bag3 interaction. YM-1 mirrored the effects of Hsp70 depletion on these signaling pathways, and in vivo administration of this drug was sufficient to suppress tumor growth in mice. Overall, our results defined Bag3 as a critical factor in Hsp70-modulated signaling and offered a preclinical proof-of-concept that the Hsp70-Bag3 complex may offer an appealing anticancer target. ©2014 American Association for Cancer Research.

  1. Fiscal 2000 achievement report. Development of technologies for waste treatment and recycling (Development of technologies for appropriate treatment of air bags); 2000 nendo haikibutsu recycle kanren gijutsu kaihatsu seika hokokusho. Air bag tekisei shori gijutsu no kaihatsu nado

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    A centralized treatment process respecting environmental protection and safety for unused air bags aboard disused automobiles is developed. In concrete terms, a heating facility owned by Daicel Chemical Industries, Ltd., is used, which includes an apparatus for examining exhaust gas dioxins and an exhaust gas treatment apparatus and, with this facility, studies are made for appropriately treating waste gas and waste water to be generated when air bag modules undergo centralized heating. Endeavors in fiscal 2000 center about (1) the development of waste gas treatment technologies, (2) development of waste water treatment technologies, (3) chemical analysis of waste water sludge, dusts and air bag residues, and (4) the study of appropriate treatment of non-azide air bag modules. As to the development of exhaust gas treatment technology, it was proved that the exhaust gas treatment system consisting of secondary incineration furnace, exhaust gas cooling tower and bag filter worked effectively. (NEDO)

  2. 75 FR 57549 - Fisker Automotive; Grant of Application for Temporary Exemption From Advanced Air Bag...

    Science.gov (United States)

    2010-09-21

    ... requirements submitted by a manufacturer of a plug-in hybrid electric car. The basis of the petition was... upgraded the requirements for air bags in passenger cars and light trucks, requiring what are commonly... completely new passenger car model. Design and development of the Karma began in late 2007. The Karma is...

  3. 77 FR 52619 - Make Inoperative Exemptions; Retrofit On-Off Switches for Air Bags

    Science.gov (United States)

    2012-08-30

    ... Advancement Act Under the National Technology Transfer and Advancement Act of 1995 (NTTAA) (Pub. L. 104-113... businesses to install retrofit on-off switches for air bags in vehicles owned by or used by persons whose... 62406) a final rule permitting motor vehicle dealers and repair businesses to install retrofit on-off...

  4. 77 FR 33998 - Make Inoperative Exemptions; Retrofit On-Off Switches for Air Bags

    Science.gov (United States)

    2012-06-08

    ... timely manner. H. National Technology Transfer and Advancement Act Under the National Technology Transfer... vehicle dealers and repair businesses to install retrofit on-off switches for air bags in vehicles owned... comment (or signing the comment, if submitted on behalf of an association, business, labor union, etc...

  5. Residential heating contribution to level of air pollutants (PAHs, major, trace, and rare earth elements): a moss bag case study.

    Science.gov (United States)

    Vuković, Gordana; Aničić Urošević, Mira; Pergal, Miodrag; Janković, Milan; Goryainova, Zoya; Tomašević, Milica; Popović, Aleksandar

    2015-12-01

    In areas with moderate to continental climates, emissions from residential heating system lead to the winter air pollution peaks. The EU legislation requires only the monitoring of airborne concentrations of particulate matter, As, Cd, Hg, Ni, and B[a]P. Transition metals and rare earth elements (REEs) have also arisen questions about their detrimental health effects. In that sense, this study examined the level of extensive set of air pollutants: 16 polycyclic aromatic hydrocarbons (PAHs), and 41 major elements, trace elements, and REEs using Sphagnum girgensohnii moss bag technique. During the winter of 2013/2014, the moss bags were exposed across Belgrade (Serbia) to study the influence of residential heating system to the overall air quality. The study was set as an extension to our previous survey during the summer, i.e., non-heating season. Markedly higher concentrations of all PAHs, Sb, Cu, V, Ni, and Zn were observed in the exposed moss in comparison to the initial values. The patterns of the moss REE concentrations normalized to North American Shale Composite and Post-Archean Australian Shales were identical across the study area but enhanced by anthropogenic activities. The results clearly demonstrate the seasonal variations in the moss enrichment of the air pollutants. Moreover, the results point out a need for monitoring of air quality during the whole year, and also of various pollutants, not only those regulated by the EU Directive.

  6. Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: Implications for oral carcinogenesis

    International Nuclear Information System (INIS)

    Lee, San San; Crabb, Simon J.; Janghra, Nari; Carlberg, Carsten; Williams, Ann C.; Cutress, Ramsey I.; Packham, Graham; Hague, Angela

    2007-01-01

    In oral cancers, cytoplasmic BAG-1 overexpression is a marker of poor prognosis. BAG-1 regulates cellular growth, differentiation and survival through interactions with diverse proteins, including the vitamin D receptor (VDR), a key regulator of keratinocyte growth and differentiation. BAG-1 is expressed ubiquitously in human cells as three major isoforms of 50 kDa (BAG-1L), 46 kDa (BAG-1M) and 36 kDa (BAG-1S) from a single mRNA. In oral keratinocytes BAG-1L, but not BAG-1M and BAG-1S, enhanced VDR transactivation in response to 1α,25-dihydroxyvitamin D 3. BAG-1L was nucleoplasmic and nucleolar, whereas BAG-1S and BAG-1M were cytoplasmic and nucleoplasmic in localisation. Having identified the nucleolar localisation sequence in BAG-1L, we showed that mutation of this sequence did not prevent BAG-1L from potentiating VDR activity. BAG-1L also potentiated transactivation of known vitamin-D-responsive gene promoters, osteocalcin and 24-hydroxylase, and enhanced VDR-dependent transcription and protein expression of the keratinocyte differentiation marker, involucrin. These results demonstrate endogenous gene regulation by BAG-1L by potentiating nuclear hormone receptor function and suggest a role for BAG-1L in 24-hydroxylase regulation of vitamin D metabolism and the cellular response of oral keratinocytes to 1α,25-dihydroxyvitamin D 3 . By contrast to the cytoplasmic BAG-1 isoforms, BAG-1L may act to suppress tumorigenesis

  7. Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

    Science.gov (United States)

    Liang, Jingjing; Sagum, Cari A; Bedford, Mark T; Sidhu, Sachdev S; Sudol, Marius; Han, Ziying; Harty, Ronald N

    2017-01-01

    Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bearing host proteins that interact with VP40, we used an EBOV PPxY-containing peptide to screen an array of 115 mammalian WW-domain-bearing proteins. Using this unbiased approach, we identified BCL2 Associated Athanogene 3 (BAG3), a member of the BAG family of molecular chaperone proteins, as a specific VP40 PPxY interactor. Here, we demonstrate that the WW-domain of BAG3 interacts with the PPxY motif of both EBOV and MARV VP40 and, unexpectedly, inhibits budding of both eVP40 and mVP40 virus-like particles (VLPs), as well as infectious VSV-EBOV recombinants. BAG3 is a stress induced protein that regulates cellular protein homeostasis and cell survival through chaperone-mediated autophagy (CMA). Interestingly, our results show that BAG3 alters the intracellular localization of VP40 by sequestering VP40 away from the plasma membrane. As BAG3 is the first WW-domain interactor identified that negatively regulates budding of VP40 VLPs and infectious virus, we propose that the chaperone-mediated autophagy function of BAG3 represents a specific host defense strategy to counteract the function of VP40 in promoting efficient egress and spread of virus particles.

  8. Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

    Directory of Open Access Journals (Sweden)

    Jingjing Liang

    2017-01-01

    Full Text Available Ebola (EBOV and Marburg (MARV viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bearing host proteins that interact with VP40, we used an EBOV PPxY-containing peptide to screen an array of 115 mammalian WW-domain-bearing proteins. Using this unbiased approach, we identified BCL2 Associated Athanogene 3 (BAG3, a member of the BAG family of molecular chaperone proteins, as a specific VP40 PPxY interactor. Here, we demonstrate that the WW-domain of BAG3 interacts with the PPxY motif of both EBOV and MARV VP40 and, unexpectedly, inhibits budding of both eVP40 and mVP40 virus-like particles (VLPs, as well as infectious VSV-EBOV recombinants. BAG3 is a stress induced protein that regulates cellular protein homeostasis and cell survival through chaperone-mediated autophagy (CMA. Interestingly, our results show that BAG3 alters the intracellular localization of VP40 by sequestering VP40 away from the plasma membrane. As BAG3 is the first WW-domain interactor identified that negatively regulates budding of VP40 VLPs and infectious virus, we propose that the chaperone-mediated autophagy function of BAG3 represents a specific host defense strategy to counteract the function of VP40 in promoting efficient egress and spread of virus particles.

  9. From macro- to microplastics - Analysis of EU regulation along the life cycle of plastic bags.

    Science.gov (United States)

    Steensgaard, Ida M; Syberg, Kristian; Rist, Sinja; Hartmann, Nanna B; Boldrin, Alessio; Hansen, Steffen Foss

    2017-05-01

    Plastic pollution and its environmental effects has received global attention the recent years. However, limited attention has so far been directed towards how plastics are regulated in a life cycle perspective and how regulatory gaps can be addressed in order to limit and prevent environmental exposure and hazards of macro- and microplastics. In this paper, we map European regulation taking outset in the life cycle perspective of plastic carrier bags: from plastic bag production to when it enters the environment. Relevant regulatory frameworks, directives and authorities along the life cycle are identified and their role in regulation of plastics is discussed. Most important regulations were identified as: the EU chemical Regulation, the Packaging and Packaging Waste Directive including the amending Directive regarding regulation of the consumption of lightweight plastic carrier bags, the Waste Framework Directive and the Directive on the Landfill of Waste. The main gaps identified relate to lack of clear definitions of categories of polymers, unambitious recycling rates and lack of consideration of macro- and microplastics in key pieces of legislation. We recommend that polymers are categorized according to whether they are polymers with the same monomer constituents (homopolymers) or with different monomer constituents (copolymers) and that polymers are no longer exempt from registration and evaluation under REACH. Plastics should furthermore have the same high level of monitoring and reporting requirements as hazardous waste involving stricter requirements to labelling, recordkeeping, monitoring and control over the whole lifecycle. Finally, we recommend that more ambitious recycle and recovery targets are set across the EU. Regulation of the consumption of lightweight plastic carrier bags should also apply to heavyweight plastic carrier bags. Last, the Marine and Water Framework Directives should specifically address plastic waste affecting water quality

  10. Modeling and Simulation of the Second-Generation Orion Crew Module Air Bag Landing System

    Science.gov (United States)

    Timmers, Richard B.; Hardy, Robin C.; Willey, Cliff E.; Welch, Joseph V.

    2009-01-01

    Air bags were evaluated as the landing attenuation system for earth landing of the Orion Crew Module (CM). Analysis conducted to date shows that airbags are capable of providing a graceful landing of the CM in nominal and off-nominal conditions such as parachute failure, high horizontal winds, and unfavorable vehicle/ground angle combinations, while meeting crew and vehicle safety requirements. The analyses and associated testing presented here surround a second generation of the airbag design developed by ILC Dover, building off of relevant first-generation design, analysis, and testing efforts. In order to fully evaluate the second generation air bag design and correlate the dynamic simulations, a series of drop tests were carried out at NASA Langley s Landing and Impact Research (LandIR) facility in Hampton, Virginia. The tests consisted of a full-scale set of air bags attached to a full-scale test article representing the Orion Crew Module. The techniques used to collect experimental data, develop the simulations, and make comparisons to experimental data are discussed.

  11. BAG3 promotes proliferation of ovarian cancer cells via post-transcriptional regulation of Skp2 expression.

    Science.gov (United States)

    Yan, Jing; Liu, Chuan; Jiang, Jing-Yi; Liu, Hans; Li, Chao; Li, Xin-Yu; Yuan, Ye; Zong, Zhi-Hong; Wang, Hua-Qin

    2017-10-01

    Bcl-2 associated athanogene 3 (BAG3) contains a modular structure, through which BAG3 interacts with a wide range of proteins, thereby affording its capacity to regulate multifaceted biological processes. BAG3 is often highly expressed and functions as a pro-survival factor in many cancers. However, the oncogenic potential of BAG3 remains not fully understood. The cell cycle regulator, S-phase kinase associated protein 2 (Skp2) is increased in various cancers and plays an important role in tumorigenesis. The current study demonstrated that BAG3 promoted proliferation of ovarian cancer cells via upregulation of Skp2. BAG3 stabilized Skp2 mRNA via its 3'-untranslated region (UTR). The current study demonstrated that BAG3 interacted with Skp2 mRNA. In addition, miR-21-5p suppressed Skp2 expression, which was compromised by forced BAG3 expression. These results indicated that at least some oncogenic functions of BAG3 were mediated through posttranscriptional regulation of Skp2 via antagonizing suppressive action of miR-21-5p in ovarian cancer cells. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Monitoring of heavy metal concentrations in home outdoor air using moss bags

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, Marcela, E-mail: arivera@creal.ca [Centre for Research in Environmental Epidemiology CREAL, Barcelona (Spain); Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona (Spain); Universitat Pompeu Fabra, Barcelona (Spain); CIBER Epidemiologia y Salud Publica (CIBERESP) (Spain); Zechmeister, Harald [University of Vienna, Faculty of Life Sciences, Vienna (Austria); Medina-Ramon, Mercedes; Basagana, Xavier [Centre for Research in Environmental Epidemiology CREAL, Barcelona (Spain); Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona (Spain); CIBER Epidemiologia y Salud Publica (CIBERESP) (Spain); Foraster, Maria [Centre for Research in Environmental Epidemiology CREAL, Barcelona (Spain); Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona (Spain); Universitat Pompeu Fabra, Barcelona (Spain); CIBER Epidemiologia y Salud Publica (CIBERESP) (Spain); Bouso, Laura [Centre for Research in Environmental Epidemiology CREAL, Barcelona (Spain); Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona (Spain); CIBER Epidemiologia y Salud Publica (CIBERESP) (Spain); Moreno, Teresa [Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona (Spain); Solanas, Pascual; Ramos, Rafael [Research Unit, Family Medicine, Girona, Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalan Institute of Health, Catalunya (Spain); Department of Medical Sciences, School of Medicine, University of Girona (Spain); Koellensperger, Gunda [University of Natural Resources and Applied Life Sciences, Vienna (Austria); Deltell, Alexandre [Polytechnic School, GREFEMA, University of Girona (Spain); Vizcaya, David [Centre for Research in Environmental Epidemiology CREAL, Barcelona (Spain); Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona (Spain); Universitat Pompeu Fabra, Barcelona (Spain); CIBER Epidemiologia y Salud Publica (CIBERESP) (Spain)

    2011-04-15

    One monitoring station is insufficient to characterize the high spatial variation of traffic-related heavy metals within cities. We tested moss bags (Hylocomium splendens), deployed in a dense network, for the monitoring of metals in outdoor air and characterized metals' long-term spatial distribution and its determinants in Girona, Spain. Mosses were exposed outside 23 homes for two months; NO{sub 2} was monitored for comparison. Metals were not highly correlated with NO{sub 2} and showed higher spatial variation than NO{sub 2}. Regression models explained 61-85% of Cu, Cr, Mo, Pb, Sb, Sn, and Zn and 72% of NO{sub 2} variability. Metals were strongly associated with the number of bus lines in the nearest street. Heavy metals are an alternative traffic-marker to NO{sub 2} given their toxicological relevance, stronger association with local traffic and higher spatial variability. Monitoring heavy metals with mosses is appealing, particularly for long-term exposure assessment, as mosses can remain on site many months without maintenance. - Research highlights: > Moss bags can be used to measure the metal's long-term spatial distribution within cities. > Heavy metals in mosses are not highly correlated with ambient NO{sub 2} concentrations. > Heavy metals show higher spatial variation and association with traffic than NO{sub 2}. > Bus lines in the nearest street explain 75-85% of Mo, Cr, Sb, Sn and Cu variability. > Moss bags are useful for long-term at home exposure assessment in epidemiological studies. - The long-term spatial distribution of heavy metals, measured with moss bags, is mainly determined by proximity to bus lines.

  13. Monitoring of heavy metal concentrations in home outdoor air using moss bags

    International Nuclear Information System (INIS)

    Rivera, Marcela; Zechmeister, Harald; Medina-Ramon, Mercedes; Basagana, Xavier; Foraster, Maria; Bouso, Laura; Moreno, Teresa; Solanas, Pascual; Ramos, Rafael; Koellensperger, Gunda; Deltell, Alexandre; Vizcaya, David

    2011-01-01

    One monitoring station is insufficient to characterize the high spatial variation of traffic-related heavy metals within cities. We tested moss bags (Hylocomium splendens), deployed in a dense network, for the monitoring of metals in outdoor air and characterized metals' long-term spatial distribution and its determinants in Girona, Spain. Mosses were exposed outside 23 homes for two months; NO 2 was monitored for comparison. Metals were not highly correlated with NO 2 and showed higher spatial variation than NO 2 . Regression models explained 61-85% of Cu, Cr, Mo, Pb, Sb, Sn, and Zn and 72% of NO 2 variability. Metals were strongly associated with the number of bus lines in the nearest street. Heavy metals are an alternative traffic-marker to NO 2 given their toxicological relevance, stronger association with local traffic and higher spatial variability. Monitoring heavy metals with mosses is appealing, particularly for long-term exposure assessment, as mosses can remain on site many months without maintenance. - Research highlights: → Moss bags can be used to measure the metal's long-term spatial distribution within cities. → Heavy metals in mosses are not highly correlated with ambient NO 2 concentrations. → Heavy metals show higher spatial variation and association with traffic than NO 2 . → Bus lines in the nearest street explain 75-85% of Mo, Cr, Sb, Sn and Cu variability. → Moss bags are useful for long-term at home exposure assessment in epidemiological studies. - The long-term spatial distribution of heavy metals, measured with moss bags, is mainly determined by proximity to bus lines.

  14. Optimizing the passenger air bag of an adaptive restraint system for multiple size occupants.

    Science.gov (United States)

    Bai, Zhonghao; Jiang, Binhui; Zhu, Feng; Cao, Libo

    2014-01-01

    The development of the adaptive occupant restraint system (AORS) has led to an innovative way to optimize such systems for multiple size occupants. An AORS consists of multiple units such as adaptive air bags, seat belts, etc. During a collision, as a supplemental protective device, air bags can provide constraint force and play a role in dissipating the crash energy of the occupants' head and thorax. This article presents an investigation into an adaptive passenger air bag (PAB). The purpose of this study is to develop a base shape of a PAB for different size occupants using an optimization method. Four typical base shapes of a PAB were designed based on geometric data on the passenger side. Then 4 PAB finite element (FE) models and a validated sled with different size dummy models were developed in MADYMO (TNO, Rijswijk, The Netherlands) to conduct the optimization to obtain the best baseline PAB that would be used in the AORS. The objective functions-that is, the minimum total probability of injuries (∑Pcomb) of the 5th percentile female and 50th and 95th percentile male dummies-were adopted to evaluate the optimal configurations. The injury probability (Pcomb) for each dummy was adopted from the U.S. New Car Assessment Program (US-NCAP). The parameters of the AORS were first optimized for different types of PAB base shapes in a frontal impact. Then, contact time duration and force between the PAB and dummy head/chest were optimized by adjusting the parameters of the PAB, such as the number and position of tethers, lower the Pcomb of the 95th percentile male dummy. According to the optimization results, 4 typical PABs could provide effective protection to 5th and 50th percentile dummies. However, due to the heavy and large torsos of the 95th percentile occupants, the current occupant restraint system does not demonstrate satisfactory protective function, particularly for the thorax.

  15. BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer.

    Science.gov (United States)

    Shields, Sarah; Conroy, Emer; O'Grady, Tony; McGoldrick, Alo; Connor, Kate; Ward, Mark P; Useckaite, Zivile; Dempsey, Eugene; Reilly, Rebecca; Fan, Yue; Chubb, Anthony; Matallanas, David Gomez; Kay, Elaine W; O'Connor, Darran; McCann, Amanda; Gallagher, William M; Coppinger, Judith A

    2018-03-20

    Triple-negative breast cancer (TNBC), is a heterogeneous disease characterised by absence of expression of the estrogen receptor (ER), progesterone receptor (PR) and lack of amplification of human epidermal growth factor receptor 2 (HER2). TNBC patients can exhibit poor prognosis and high recurrence stages despite early response to chemotherapy treatment. In this study, we identified a pro-survival signalling protein BCL2- associated athanogene 3 (BAG3) to be highly expressed in a subset of TNBC cell lines and tumour tissues. High mRNA expression of BAG3 in TNBC patient cohorts significantly associated with a lower recurrence free survival. The epidermal growth factor receptor (EGFR) is amplified in TNBC and EGFR signalling dynamics impinge on cancer cell survival and disease recurrence. We found a correlation between BAG3 and EGFR expression in TNBC cell lines and determined that BAG3 can regulate tumour cell proliferation, migration and invasion in EGFR expressing TNBC cells lines. We identified an interaction between BAG3 and components of the EGFR signalling networks using mass spectrometry. Furthermore, BAG3 contributed to regulation of proliferation in TNBC cell lines by reducing the activation of components of the PI3K/AKT and FAK/Src signalling subnetworks. Finally, we found that combined targeting of BAG3 and EGFR was more effective than inhibition of EGFR with Cetuximab alone in TNBC cell lines. This study demonstrates a role for BAG3 in regulation of distinct EGFR modules and highlights the potential of BAG3 as a therapeutic target in TNBC.

  16. Bag breakup of low viscosity drops in the presence of a continuous air jet

    International Nuclear Information System (INIS)

    Kulkarni, V.; Sojka, P. E.

    2014-01-01

    This work examines the breakup of a single drop of various low viscosity fluids as it deforms in the presence of continuous horizontal air jet. Such a fragmentation typically occurs after the bulk liquid has disintegrated upon exiting the atomizer and is in the form of an ensemble of drops which undergo further breakup. The drop deformation and its eventual disintegration is important in evaluating the efficacy of a particular industrial process, be it combustion in automobile engines or pesticide spraying in agricultural applications. The interplay between competing influences of surface tension and aerodynamic disruptive forces is represented by the Weber number, We, and Ohnesorge number, Oh, and used to describe the breakup morphology. The breakup pattern considered in our study corresponds to that of a bag attached to a toroidal ring which occurs from ∼12 2 ), is found to match well with experimental data ([L.-P. Hsiang and G. M. Faeth, Int. J. Multiphase Flow 21(4), 545–560 (1995)] and [R. S. Brodkey, “Formation of drops and bubbles,” in The Phenomena of Fluid Motions (Addison-Wesley, Reading, 1967)]). An exponential growth in the radial extent of the deformed drop and the streamline dimension of the bag is predicted by a theoretical model and confirmed by experimental findings. These quantities are observed to strongly depend on We. However, their dependence on Oh is weak

  17. STS 31 PAYLOAD HUBBLE SPACE TELESCOPE ENCLOSED IN AN AIR-TIGHT PLASTIC BAG FOR PROTECTION IN VERTICA

    Science.gov (United States)

    1989-01-01

    Preparations are made to enclose the Hubble Space Telescope [HST] inside an air-tight plastic bag in the VPF. Processing of the 94- inch primary mirror telescope for launch on the Discovery in March 1990, involves working within strict controls to prevent contamination.

  18. 75 FR 51870 - Wheego Electric Cars, Inc.; Receipt of Application for Temporary Exemption From Advanced Air Bag...

    Science.gov (United States)

    2010-08-23

    ...-0118] Wheego Electric Cars, Inc.; Receipt of Application for Temporary Exemption From Advanced Air Bag... with the procedures in 49 CFR part 555, Wheego Electric Cars, Inc., has petitioned the agency for a... requirements submitted by a manufacturer of a small electric car. II. Overview of Wheego's Petition for...

  19. 76 FR 7898 - Wheego Electric Cars, Inc.; Grant of Application for Temporary Exemption From Advanced Air Bag...

    Science.gov (United States)

    2011-02-11

    ...-0118] Wheego Electric Cars, Inc.; Grant of Application for Temporary Exemption From Advanced Air Bag... grants the petition of Wheego Electric Cars, Inc. (Wheego) for the temporary exemption of its Whip LiFe... manufacturer of a plug-in electric car. The stated basis of the petition was that requiring compliance would...

  20. The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth.

    Science.gov (United States)

    Chiappetta, Gennaro; Basile, Anna; Barbieri, Antonio; Falco, Antonia; Rosati, Alessandra; Festa, Michelina; Pasquinelli, Rosa; Califano, Daniela; Palma, Giuseppe; Costanzo, Raffaele; Barcaroli, Daniela; Capunzo, Mario; Franco, Renato; Rocco, Gaetano; Pascale, Maria; Turco, Maria Caterina; De Laurenzi, Vincenzo; Arra, Claudio

    2014-08-30

    BAG3, member the HSP70 co-chaperones family, has been shown to play a relevant role in the survival, growth and invasiveness of different tumor types. In this study, we investigate the expression of BAG3 in 66 specimens from different lung tumors and the role of this protein in small cell lung cancer (SCLC) tumor growth. Normal lung tissue did not express BAG3 while we detected the expression of BAG3 by immunohistochemistry in all the 13 squamous cell carcinomas, 13 adenocarcinomas and 4 large cell carcinomas. Furthermore, we detected BAG3 expression in 22 of the 36 SCLCs analyzed. The role on SCLC cell survival was determined by down-regulating BAG3 levels in two human SCLC cell lines, i.e. H69 and H446, in vitro and measuring cisplatin induced apoptosis. Indeed down-regulation of BAG3 determines increased cell death and sensitizes cells to cisplatin treatment. The effect of BAG3 down-regulation on tumor growth was also investigated in an in vivo xenograft model by treating mice with an adenovirus expressing a specific bag3 siRNA. Treatment with bag3 siRNA-Ad significantly reduced tumor growth and improved animal survival. In conclusion we show that a subset of SCLCs over express BAG3 that exerts an anti-apoptotic effect resulting in resistance to chemotherapy.

  1. Bag breakup of low viscosity drops in the presence of a continuous air jet

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, V., E-mail: vkulkarn@purdue.edu; Sojka, P. E. [Maurice J. Zucrow Laboratories, Purdue University, West Lafayette, Indiana 47906 (United States)

    2014-07-15

    This work examines the breakup of a single drop of various low viscosity fluids as it deforms in the presence of continuous horizontal air jet. Such a fragmentation typically occurs after the bulk liquid has disintegrated upon exiting the atomizer and is in the form of an ensemble of drops which undergo further breakup. The drop deformation and its eventual disintegration is important in evaluating the efficacy of a particular industrial process, be it combustion in automobile engines or pesticide spraying in agricultural applications. The interplay between competing influences of surface tension and aerodynamic disruptive forces is represented by the Weber number, We, and Ohnesorge number, Oh, and used to describe the breakup morphology. The breakup pattern considered in our study corresponds to that of a bag attached to a toroidal ring which occurs from ∼12 < We < ∼16. We aim to address several issues connected with this breakup process and their dependence on We and Oh which have been hitherto unexplored. The We boundary at which breakup begins is theoretically determined and the expression obtained, We=12(1+2/3Oh{sup 2}), is found to match well with experimental data ([L.-P. Hsiang and G. M. Faeth, Int. J. Multiphase Flow 21(4), 545–560 (1995)] and [R. S. Brodkey, “Formation of drops and bubbles,” in The Phenomena of Fluid Motions (Addison-Wesley, Reading, 1967)]). An exponential growth in the radial extent of the deformed drop and the streamline dimension of the bag is predicted by a theoretical model and confirmed by experimental findings. These quantities are observed to strongly depend on We. However, their dependence on Oh is weak.

  2. BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism.

    Science.gov (United States)

    Rodríguez, Andrea E; López-Crisosto, Camila; Peña-Oyarzún, Daniel; Salas, Daniela; Parra, Valentina; Quiroga, Clara; Morawe, Tobias; Chiong, Mario; Behl, Christian; Lavandero, Sergio

    2016-01-01

    Autophagy is mainly regulated by post-translational and lipid modifications of ATG proteins. In some scenarios, the induction of autophagy is accompanied by increased levels of certain ATG mRNAs such as MAP1LC3B/LC3B, ATG5 or ATG12. However, little is known about the regulation of ATG protein synthesis at the translational level. The cochaperone of the HSP70 system BAG3 (BCL2-associated athanogene 3) has been associated to LC3B lipidation through an unknown mechanism. In the present work, we studied how BAG3 controls autophagy in HeLa and HEK293 cells. Our results showed that BAG3 regulates the basal amount of total cellular LC3B protein by controlling its mRNA translation. This effect was apparently specific to LC3B because other ATG protein levels were not affected. BAG3 knockdown did not affect LC3B lipidation induced by nutrient deprivation or proteasome inhibition. We concluded that BAG3 maintains the basal amount of LC3B protein by controlling the translation of its mRNA in HeLa and HEK293 cells.

  3. 14 CFR 223.24 - Transportation of empty mail bags.

    Science.gov (United States)

    2010-01-01

    ... PROCEEDINGS) ECONOMIC REGULATIONS FREE AND REDUCED-RATE TRANSPORTATION International Travel § 223.24 Transportation of empty mail bags. Any carrier authorized to engage in foreign air transportation may transport...

  4. The hydrodynamics of air-filled bags for wave energy conversion

    DEFF Research Database (Denmark)

    Greaves, Deborah; Hann, Martyn; Kurniawan, Adi

    of a fabric encased within an array of longitudinal tendons. In the first configuration, the bag is floating and ballasted such that it pierces the free surface. In the second configuration, the bag is completely submerged and connected at its top to a rigid float and at its bottom to a weight. In the third...

  5. BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

    Science.gov (United States)

    Feldman, Arthur M; Gordon, Jennifer; Wang, JuFang; Song, Jianliang; Zhang, Xue-Qian; Myers, Valerie D; Tilley, Douglas G; Gao, Erhe; Hoffman, Nicholas E; Tomar, Dhanendra; Madesh, Muniswamy; Rabinowitz, Joseph; Koch, Walter J; Su, Feifei; Khalili, Kamel; Cheung, Joseph Y

    2016-03-01

    Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to loss of protein, are associated with familial cardiomyopathy. Furthermore, BAG3 levels have been found to be reduced in end-stage non-familial failing myocardium. In contrast to neonatal myocytes in which BAG3 is found in the cytoplasm and involved in protein quality control and apoptosis, in adult mouse left ventricular (LV) myocytes BAG3 co-localized with Na(+)-K(+)-ATPase and L-type Ca(2+) channels in the sarcolemma and t-tubules. BAG3 co-immunoprecipitated with β1-adrenergic receptor, L-type Ca(2+) channels and phospholemman. To simulate decreased BAG3 protein levels observed in human heart failure, we targeted BAG3 by shRNA (shBAG3) in adult LV myocytes. Reducing BAG3 by 55% resulted in reduced contraction and [Ca(2+)]i transient amplitudes in LV myocytes stimulated with isoproterenol. L-type Ca(2+) current (ICa) and sarcoplasmic reticulum (SR) Ca(2+) content but not Na(+)/Ca(2+) exchange current (INaCa) or SR Ca(2+) uptake were reduced in isoproterenol-treated shBAG3 myocytes. Forskolin or dibutyryl cAMP restored ICa amplitude in shBAG3 myocytes to that observed in WT myocytes, consistent with BAG3 having effects upstream and at the level of the receptor. Resting membrane potential and action potential amplitude were unaffected but APD50 and APD90 were prolonged in shBAG3 myocytes. Protein levels of Ca(2+) entry molecules and other important excitation-contraction proteins were unchanged in myocytes with lower BAG3. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the β1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. Copyright © 2016 Elsevier Ltd. All rights

  6. BAG3 regulates contractility and Ca2+ homeostasis in adult mouse ventricular myocytes

    Science.gov (United States)

    Feldman, Arthur M.; Gordon, Jennifer; Wang, JuFang; Song, Jianliang; Zhang, Xue-Qian; Myers, Valerie D.; Tilley, Douglas G.; Gao, Erhe; Hoffman, Nicholas E.; Tomar, Dhanendra; Madesh, Muniswamy; Rabinowitz, Joseph; Koch, Walter J.; Su, Feifei; Khalili, Kamel; Cheung, Joseph Y.

    2016-01-01

    Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to loss of protein, are associated with familial cardiomyopathy. Furthermore, BAG3 levels have been found to be reduced in end-stage non-familial failing myocardium. In contrast to neonatal myocytes in which BAG3 is found in the cytoplasm and involved in protein quality control and apoptosis, in adult mouse left ventricular (LV) myocytes BAG3 co-localized with Na+-K+-ATPase and L-type Ca2+ channels in the sarcolemma and t-tubules. BAG3 co-immunoprecipitated with β1-adrenergic receptor, L-type Ca2+ channels and phospholemman. To simulate decreased BAG3 protein levels observed in human heart failure, we targeted BAG3 by shRNA (shBAG3) in adult LV myocytes. Reducing BAG3 by 55% resulted in reduced contraction and [Ca2+]i transient amplitudes in LV myocytes stimulated with isoproterenol. L-type Ca2+ current (ICa) and sarcoplasmic reticulum (SR) Ca2+ content but not Na+/Ca2+ exchange current (INaCa) or SR Ca2+ uptake were reduced in isoproterenol-treated shBAG3 myocytes. Forskolin or dibutyrl cAMP restored ICa amplitude in shBAG3 myocytes to that observed in WT myocytes, consistent with BAG3 having effects upstream and at the level of the receptor. Resting membrane potential and action potential amplitude were unaffected but APD50 and APD90 were prolonged in shBAG3 myocytes. Protein levels of Ca2+ entry molecules and other important excitation-contraction proteins were unchanged in myocytes with lower BAG3. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the β1-adrenergic receptor and L-type Ca2+ channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. PMID:26796036

  7. Compliance with air quality regulations

    International Nuclear Information System (INIS)

    Steen, D.V.; Tackett, D.L.

    1990-01-01

    Due to the probable passage of Clean Air Act Amendments in 1990, electric utilities throughout the United States are faced with numerous choices to comply with the new acid rain regulations, expected in 1991. The choice of a compliance plan is not a simple task. Every compliance option will be costly. At Ohio Edison, deliberations are quite naturally influenced by past compliance with air quality regulations. This paper discusses compliance with air quality regulations in the 1970's, clean coal technologies and advanced scrubbers, and compliance with air quality regulations in 1995 - 2000. The choice of a compliance strategy for many utilities will involve serving customer loads through some combination of scrubbers, clean coal technologies, fuel switching, fuel blending, redispatch of units, and emissions trading. Whatever the final choice, it must be economic while providing sufficient flexibility to accommodate the critical uncertainties of load growth, state regulatory treatment, markets for emission allowances, advancements in control technologies, additional federal requirements for air emissions, equipment outages and fuel supply disruptions.s

  8. An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.

    Science.gov (United States)

    Morelli, Federica F; Mediani, Laura; Heldens, Lonneke; Bertacchini, Jessika; Bigi, Ilaria; Carrà, Arianna Dorotea; Vinet, Jonathan; Carra, Serena

    2017-07-01

    The ten mammalian small heat shock proteins (sHSPs/HSPBs) show a different expression profile, although the majority of them are abundant in skeletal and cardiac muscles. HSPBs form hetero-oligomers and homo-oligomers by interacting together and complexes containing, e.g., HSPB2/HSPB3 or HSPB1/HSPB5 have been documented in mammalian cells and muscles. Moreover, HSPB8 associates with the Hsc70/Hsp70 co-chaperone BAG3, in mammalian, skeletal, and cardiac muscle cells. Interaction of HSPB8 with BAG3 regulates its stability and function. Weak association of HSPB5 and HSPB6 with BAG3 has been also reported upon overexpression in cells, supporting the idea that BAG3 might indirectly modulate the function of several HSPBs. However, it is yet unknown whether other HSPBs highly expressed in muscles such as HSPB2 and HSPB3 also bind to BAG3. Here, we report that in mammalian cells, upon overexpression, HSPB2 binds to BAG3 with an affinity weaker than HSPB8. HSPB2 competes with HSPB8 for binding to BAG3. In contrast, HSPB3 negatively regulates HSPB2 association with BAG3. In human myoblasts that express HSPB2, HSPB3, HSPB8, and BAG3, the latter interacts selectively with HSPB8. Combining these data, it supports the interpretation that HSPB8-BAG3 is the preferred interaction.

  9. BAG3 regulates contractility and Ca2+ homeostasis in adult mouse ventricular myocytes

    OpenAIRE

    Feldman, Arthur M.; Gordon, Jennifer; Wang, JuFang; Song, Jianliang; Zhang, Xue-Qian; Myers, Valerie D.; Tilley, Douglas G.; Gao, Erhe; Hoffman, Nicholas E.; Tomar, Dhanendra; Madesh, Muniswamy; Rabinowitz, Joseph; Koch, Walter J.; Su, Feifei; Khalili, Kamel

    2016-01-01

    Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to loss of protein, are associated with familial cardiomyopathy. Furthermore, BAG3 levels have been found to be reduced in end-stage non-familial failing myocardium. In contrast to neonatal myocytes in which BAG3 is found in the cytoplasm and involved in protein quality control and apoptosis, in adult mouse left ventricular (...

  10. The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

    Science.gov (United States)

    Kathage, Barbara; Gehlert, Sebastian; Ulbricht, Anna; Lüdecke, Laura; Tapia, Victor E; Orfanos, Zacharias; Wenzel, Daniela; Bloch, Wilhelm; Volkmer, Rudolf; Fleischmann, Bernd K; Fürst, Dieter O; Höhfeld, Jörg

    2017-01-01

    The cochaperone BAG3 is a central protein homeostasis factor in mechanically strained mammalian cells. It mediates the degradation of unfolded and damaged forms of the actin-crosslinker filamin through chaperone-assisted selective autophagy (CASA). In addition, BAG3 stimulates filamin transcription in order to compensate autophagic disposal and to maintain the actin cytoskeleton under strain. Here we demonstrate that BAG3 coordinates protein synthesis and autophagy through spatial regulation of the mammalian target of rapamycin complex 1 (mTORC1). The cochaperone utilizes its WW domain to contact a proline-rich motif in the tuberous sclerosis protein TSC1 that functions as an mTORC1 inhibitor in association with TSC2. Interaction with BAG3 results in a recruitment of TSC complexes to actin stress fibers, where the complexes act on a subpopulation of mTOR-positive vesicles associated with the cytoskeleton. Local inhibition of mTORC1 is essential to initiate autophagy at sites of filamin unfolding and damage. At the same time, BAG3-mediated sequestration of TSC1/TSC2 relieves mTORC1 inhibition in the remaining cytoplasm, which stimulates protein translation. In human muscle, an exercise-induced association of TSC1 with the cytoskeleton coincides with mTORC1 activation in the cytoplasm. The spatial regulation of mTORC1 exerted by BAG3 apparently provides the basis for a simultaneous induction of autophagy and protein synthesis to maintain the proteome under mechanical strain. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. 78 FR 65426 - Technical Report: Evaluation of the Certified-Advanced Air Bags

    Science.gov (United States)

    2013-10-31

    ... bags. Procedural Matters How can I influence NHTSA's thinking on this subject? NHTSA welcomes public... Washington, DC, on October 28, 2013. James F. Simons, Director, Office of Regulatory Analysis and Evaluation...

  12. BAG3 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1.

    Science.gov (United States)

    Du, Feng; Li, Si; Wang, Tian; Zhang, Hai-Yan; Li, De-Tian; Du, Zhen-Xian; Wang, Hua-Qin; Wang, Yan-Qiu

    2015-01-01

    Previously we have demonstrated that Bcl-2-associated athanogene 3 (BAG3) is increased in renal fibrosis using a rat unilateral ureteral obstruction model. The current study investigated the role of BAG3 in renal fibrosis using transforming growth factor (TGF)-β1-treated human proximal tubular epithelial (HK-2) cells. An upregulation of BAG3 in vitro models was observed, which correlated with the increased synthesis of extracellular matrix (ECM) proteins and expression of tissue-type plasminogen activator inhibitor (PAI)-1. Blockade of BAG3 induction by shorting hairpin RNA suppressed the expression of ECM proteins but had no effect on PAI-1 expression induced by TGF-β1. Forced overexpression of BAG3 selectively increased collagens. TGF-β1-induced BAG3 expression in HK-2 cells was attenuated by ERK1/2 and JNK MAPK inhibitors. In addition, forced BAG3 overexpression blocked attenuation of collagens expression by ERK1/2 and JNK inhibitors. These data suggest that ERK1/2 and JNK signaling events are involved in modulating the expression of BAG3, which would ultimately contribute to renal fibrosis by enhancing the synthesis and deposition of ECM proteins.

  13. Air pollution control regulation. [Japan

    Energy Technology Data Exchange (ETDEWEB)

    Sogabe, K

    1975-05-01

    The Basic Law for Environmental Pollution Control is reviewed. The fundamental ideology of pollution control, range of pollution control, environmental standards, and national policy concerning pollution control are discussed. The content of the Air Pollution Control Law is summarized. The purpose of the Air Pollution Control Law, a list of substances regulated by the law, the type of facilities regulated by the law, control standards, type of control means, and emission standards for flue gas (sulfur oxides, particulate matters, and toxic substances) are described. The environmental standard for each pollutant and the target date for achieving the environmental standard are also given. The list of cities where the 7-rank K value control regulation for SOx is enforced is given. The procedure for registration in compliance with the law is also described.

  14. Potential bags

    International Nuclear Information System (INIS)

    Ferreira, P.L.; Tomio, L.

    1992-01-01

    In this paper, relativistic confining potential models, endowed with bag constants associated to volume energy terms, are investigated. In contrast to the usual bag model, these potential bags are distinguished by having smeared bag surfaces. Based on the dynamical assumptions underlying the fuzzy bag model, these bag constants are derived from the corresponding energy-momentum tensor. Explicit expressions for the single-quark energies and for the nucleon bag constant are obtained by means of an improved analytical version of the saddle-point variational method for the Dirac equation with confining power-law potentials of the scalar plus vector (S + V) or pure scalar (S) type

  15. BAG3 regulates formation of the SNARE complex and insulin secretion

    Science.gov (United States)

    Iorio, V; Festa, M; Rosati, A; Hahne, M; Tiberti, C; Capunzo, M; De Laurenzi, V; Turco, M C

    2015-01-01

    Insulin release in response to glucose stimulation requires exocytosis of insulin-containing granules. Glucose stimulation of beta cells leads to focal adhesion kinase (FAK) phosphorylation, which acts on the Rho family proteins (Rho, Rac and Cdc42) that direct F-actin remodeling. This process requires docking and fusion of secretory vesicles to the release sites at the plasma membrane and is a complex mechanism that is mediated by SNAREs. This transiently disrupts the F-actin barrier and allows the redistribution of the insulin-containing granules to more peripheral regions of the β cell, hence facilitating insulin secretion. In this manuscript, we show for the first time that BAG3 plays an important role in this process. We show that BAG3 downregulation results in increased insulin secretion in response to glucose stimulation and in disruption of the F-actin network. Moreover, we show that BAG3 binds to SNAP-25 and syntaxin-1, two components of the t-SNARE complex preventing the interaction between SNAP-25 and syntaxin-1. Upon glucose stimulation BAG3 is phosphorylated by FAK and dissociates from SNAP-25 allowing the formation of the SNARE complex, destabilization of the F-actin network and insulin release. PMID:25766323

  16. The influence of typical ways of operating and air-handling unit on the sensory pollution load from used bag filters

    DEFF Research Database (Denmark)

    Mysen, M.; Clausen, Geo; Bekö, Gabriel

    2003-01-01

    An experiment was performed to determine whether the sensory pollution emitted from a bag filter that had been used for 3 months in a suburban area in Denmark was influenced by different ways of operating the air-handling unit (AHU). Samples of the used filter were pre-conditioned to simulate thr...... the airflow outside working hours would significantly increase the sensory pollution emitted by a used bag filter immediately after the AHU is turned on, in comparison with continuous airflow through the AHU (P...... operating conditions: 1) switched off overnight; 2) airflow reduced to 10% overnight; and 3) continuous 100% operation. Outside air passed through the samples and the acceptability of the air after the filter was assessed by a panel of subjects. The results indicate that turning off the AHU or reducing...

  17. 7 CFR 201.41 - Bags.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Bags. 201.41 Section 201.41 Agriculture Regulations of... Sampling in the Administration of the Act § 201.41 Bags. (a) For lots of six bags or less, each bag shall be sampled. A total of at least five trierfuls shall be taken. (b) For lots of more than six bags...

  18. Soumen Bag

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. Soumen Bag. Articles written in Sadhana. Volume 38 Issue 1 February 2013 pp 133-168. A survey on optical character recognition for Bangla and Devanagari scripts · Soumen Bag Gaurav Harit · More Details Abstract Fulltext PDF. The past few decades have witnessed an intensive research on ...

  19. 75 FR 30900 - Fisker Automotive; Receipt of Application for Temporary Exemption From Advanced Air Bag...

    Science.gov (United States)

    2010-06-02

    ... good faith to comply with the standard.\\1\\ \\1\\ To view the application, go to http://www.regulations... economic hardship to a manufacturer that has tried in good faith to comply with the standard. NHTSA has... to a manufacturer that has tried in good faith to comply with the standard. According to the petition...

  20. [A study concerning how much weight schoolchildren carry in their bags, involving four schools in the metropolitan area of Buenos Aires, Argentina].

    Science.gov (United States)

    Laíño, Fernando A; Santa María, Claudio J; Bazán, Nelio E; Mainero, Daniel D

    2013-01-01

    Determining the weight children carry in their bags to school (absolute and relative values) and the distance walked during home-school routes, involving students from four schools in the metropolitan area of Buenos Aires. The study involved 751 primary (4th to 6th grades) and secondary (1st to 3rd years) level students who were attending three private schools and one public one. Body and bag weights were measured and the children were asked about the distance (in blocks) they walked from school to home. The study involved a descriptive analysis and contrasted the students by gender, educational level, type of school and grade or year. Possible associations between variables were ascertained. The group was divided into those carrying bags weighing less than 10% of their body weight and those who carrying 10% (considered a critical value) and more; frequencies were calculated by the type of bag being used. 68% of the sample were carrying 10% or more of their body weight (P42=10.13%): 66% in male (P44=10.12%) and 60% in female children (P40=10.2%). Private school students carried more weight than public school children (p<0.05) and younger students carried a greater weight than older students (p<0.05) in both educational levels. Most children were carrying relative weights well above that recommended and female students were most affected. Younger students carried higher absolute and relative weights.

  1. Launching Garbage-Bag Balloons.

    Science.gov (United States)

    Kim, Hy

    1997-01-01

    Presents a modification of a procedure for making and launching hot air balloons made out of garbage bags. Student instructions for balloon construction, launching instructions, and scale diagrams are included. (DDR)

  2. Grandfather regulations, new source bias, and state air toxics regulations

    International Nuclear Information System (INIS)

    Levinson, Arik

    1999-01-01

    This paper uses plant-level data from the Census of Manufactures and the variation in toxic air pollution regulations across states to measure the effects of laws that are more stringent for new sources of pollution than for existing sources (so-called 'grandfather' regulations). Of particular interest is the resulting 'new source bias' and its effects on capital vintage and investment. Two industries are examined: commercial printing, which has a local product market; and paint manufacturing, which has a more national market. In general, there seem to be no statistically significant differences in capital vintage or investment between plants in states that grandfather new sources of pollution, plants in states that have no air toxics regulations, and plants in states that regulate both new and existing sources

  3. Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.

    Directory of Open Access Journals (Sweden)

    Regina T Knapp

    Full Text Available Hsp70 binding protein 1 (HspBP1 and Bcl2-associated athanogene 1 (BAG-1, the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70 chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. An appropriate exchange rate of ADP/ATP is crucial for chaperone-dependent protein folding processes. Among Hsp70 client proteins are steroid receptors such as the glucocorticoid receptor (GR, the mineralocorticoid receptor (MR, and the androgen receptor (AR. BAG-1 diversely affects steroid receptor activity, while to date the influence of HspBP1 on steroid receptor function is mostly unknown. Here, we compared the influence of HspBP1 and BAG-1M on Hsp70-mediated steroid receptor folding complexes and steroid receptor activity. Coimmunoprecipitation studies indicated preferential binding of Hsp40 and the steroid receptors to BAG-1M as compared to HspBP1. Furthermore, Hsp70 binding to the ligand-binding domain of GR was reduced in the presence of HspBP1 but not in the presence of BAG-1M as shown by pull-down assays. Reporter gene experiments revealed an inhibitory effect on GR, MR, and AR at a wide range of HspBP1 protein levels and at hormone concentrations at or approaching saturation. BAG-1M exhibited a transition from stimulatory effects at low BAG-1M levels to inhibitory effects at higher BAG-1M levels. Overall, BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes and on receptor function with important implications for steroid receptor physiology.

  4. Bag facaden

    DEFF Research Database (Denmark)

    Hvidtfeldt, Susanne; Sjøstedt, Lotte Ebsen

    Bag facaden er et task-baseret materiale der går bag om danskerne kulturelt og sprogligt. Det henvender sig til spor 3-learnere på de sidste trin, men kan i nogle klasser godt anvendes tidligere. Teksterne i bogen er autentiske dagbogsnotater skrevet af danskere i alle aldre. Den nærværende og...... eller hun er i sin sprogtilegnelse og i sit behov for viden om dansk kultur og samfund. Derudover forbereder det fint learneren til almenprøve 2 og DUF eksamen, både hvad angår indhold og arbejdsformer. I forløb hvor der stiles mod folkeskolens afgangseksamner er Bag facaden relevant som supplerende...

  5. Urine drainage bags

    Science.gov (United States)

    Leg bag ... the catheter from your bladder into the leg bag. Your leg bag will be attached to you all day. You ... freely with it. You can hide your leg bag under skirts, dresses, or pants. They come in ...

  6. Sourav Bag

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Sourav Bag. Articles written in Journal of Chemical Sciences. Volume 128 Issue 3 March 2016 pp 339-347 Regular Articles. On the electrocatalytic activity of nitrogen-doped reduced graphene Oxide:Does the nature of nitrogen really control the activity towards oxygen ...

  7. Report on achievements in fiscal 1998. Development of a waste disposal and recycle related technology. (Development of a technology to dispose of air bags adequately); 1998 nendo haikibutsu shori recycle kanren gijutsu kaihatsu air bag tekisei shori gijutsu no kaihatsu nado seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-01

    This technological development is intended to develop a process technology to dispose adequately of air bags convergently when they are removed from waste cars, with consideration paid on environmental and safety aspects. This technology that can dispose of air bags remaining as air bag modules (ABM) in large quantity and adequately can solve the problems of maloperation in opening them in cars and noise in conventional disposal methods. The recovery and disposal system using an inflator can be expected of reducing work load on dismantling contractors and enhancing the work safety. Furthermore, the energy saving process utilizing combustion of plastics can save resources. However, this technology has not elucidated how dioxins, dust, smoke, sulfides, and nitrogen oxides are generated and how the generation can be prevented. Therefore, an exhaust gas dioxin testing facility and an exhaust gas treating facility were installed additionally to the existing heating treatment facility to develop a disposal technology to treat adequately the exhaust gases generated when ABMs are disposed conveergently in large quantity, and treat the waste water discharged from the facilities. Fiscal 1998 has performed preliminary tests to accumulate fundamental data, and design and installation of the above two facilities. (NEDO)

  8. Sea spray production by bag breakup mode of fragmentation of the air-water interface at strong and hurricane wind

    Science.gov (United States)

    Troitskaya, Yuliya; Kandaurov, Alexander; Ermakova, Olga; Kozlov, Dmitry; Sergeev, Daniil; Zilitinkevich, Sergej

    2016-04-01

    Sea sprays is a typical element of the marine atmospheric boundary layer (MABL) of large importance for marine meteorology, atmospheric chemistry and climate studies. They are considered as a crucial factor in the development of hurricanes and severe extratropical storms, since they can significantly enhance exchange of mass, heat and momentum between the ocean and the atmosphere. This exchange is directly provided by spume droplets with the sizes from 10 microns to a few millimeters mechanically torn off the crests of a breaking waves and fall down to the ocean due to gravity. The fluxes associated with the spray are determined by the rate of droplet production at the surface quantified by the sea spray generation function (SSGF), defined as the number of spray particles of radius r produced from the unit area of water surface in unit time. However, the mechanism of spume droplets' formation is unknown and empirical estimates of SSGF varied over six orders of magnitude; therefore, the production rate of large sea spray droplets is not adequately described and there are significant uncertainties in estimations of exchange processes in hurricanes. Experimental core of our work comprise laboratory experiments employing high-speed video-filming, which have made it possible to disclose how water surface looks like at extremely strong winds and how exactly droplets are torn off wave crests. We classified events responsible for spume droplet, including bursting of submerged bubbles, generation and breakup of "projections" or liquid filaments (Koa, 1981) and "bag breakup", namely, inflating and consequent blowing of short-lived, sail-like pieces of the water-surface film, "bags". The process is similar to "bag-breakup" mode of fragmentation of liquid droplets and jets in gaseous flows. Basing on statistical analysis of results of these experiments we show that the main mechanism of spray-generation is attributed to "bag-breakup mechanism On the base of general principles

  9. Management of the stalked barnacle (Pollicipes pollicipes fishery in the Berlengas Nature Reserve (Portugal: evaluation of bag and size limit regulation measures

    Directory of Open Access Journals (Sweden)

    David Jacinto

    2011-04-01

    Full Text Available The stalked barnacle Pollicipes pollicipes (Gmelin, 1790 is an important shellfish resource in Portugal. Due to the social-economic importance of barnacle harvesting, a management plan aimed at achieving a controlled and sustainable activity (including temporal and spatial closures, rotational harvesting, a limited number of harvesting licenses, bag and size limits for catches and catch reporting was implemented in 2000 at the Berlengas Nature Reserve (RNB in central Portugal. We evaluated the bag and size limits imposed by the management plan, performing observations on harvesting activity and asking licensed harvesters and RNB staff about these measures. Both inquiries and observations suggest that licensed harvesters are not following the bag and size limits imposed. Mean amounts captured in RNB varied from 14 to 24 kg per harvester/day, but 25% of the observations corresponded to higher catches per individual than the total amount allowed (20 kg. Only half of the sampled amounts (taken in autumn 2005 and 2006 were in agreement with the size limit regulation and 50% of the total biomass comprised individuals of maximal rostro-carinal length (RC ≥ 25 mm. For most harvesters, size limit is the most difficult management rule to fulfil. Both harvesters and RNB staff agree that surveillance is scarce and is a major problem of this fishing activity. In order to achieve a more sustainable use of this resource, we propose the implementation of a more effective surveillance and monitoring plan, the definition of a unique landing site, the maintenance of the bag limit (20 kg and a reduction of the size limit (50% of total biomass comprising individuals ≥ 22 mm RC.

  10. Bag filters

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, M; Komeda, I; Takizaki, K

    1982-01-01

    Bag filters are widely used throughout the cement industry for recovering raw materials and products and for improving the environment. Their general mechanism, performance and advantages are shown in a classification table, and there are comparisons and explanations. The outer and inner sectional construction of the Shinto ultra-jet collector for pulverized coal is illustrated and there are detailed descriptions of dust cloud prevention, of measures used against possible sources of ignition, of oxygen supply and of other topics. Finally, explanations are given of matters that require careful and comprehensive study when selecting equipment.

  11. Regulations Concerning Agriculture and Air Pollution

    Directory of Open Access Journals (Sweden)

    Chiara Bertora

    2010-03-01

    Full Text Available The main issues related to the atmospheric pollution are the stratospheric ozone depletion, the transboundary air pollution, the troposphere air quality and the climate change. The three last decades have seen the birth of several measures for the atmosphere safeguard. Agricultural activities play a key role in determining, preventing and mitigating atmospheric pollution. The emission to atmosphere of different ozone-depleting substances is regulated by the Montreal Protocol. The role of agriculture activity in ozone depletion is linked to the utilization of methyl bromide as soil sterilant and to the emission of nitrogen oxides and nitrous oxide, from agricultural soils. The Convention on long-range transboundary air pollution regulates the emission of several pollutants, i.e. sulphur dioxide, nitrogen oxides, ammonia, non methane volatile organic compounds, carbon monoxide, heavy metals, persistent organic pollutants, and tropospheric ozone. The agriculture sector is responsible for a large part of the emissions of ammonia and nitrogen oxides, mainly through manure management and nitrogen fertilization, and of most persistent organic pollutants, largely used in the past as insecticides and fungicides. The increase of the greenhouse gases (GHGs concentration in the atmosphere is under the control of the Kyoto Protocol. Agriculture accounts for 59-63% of global non-CO2 GHGs emissions but at the same time it contributes to the atmospheric CO2 concentration stabilisation through the substitution of fossil fuels by biofuels and the sequestration of C in soil and vegetal biomass. In this paper we provide an outline of the numerous scientific and legislative initiatives aimed at protecting the atmosphere, and we analyse in detail the agriculture sector in order to highlight both its contribution to atmospheric pollution and the actions aimed at preventing and mitigating it.

  12. Short- and long-term efficacy of intragastric air-filled balloon (Heliosphere® BAG) among obese patients.

    Science.gov (United States)

    Giuricin, M; Nagliati, C; Palmisano, S; Simeth, C; Urban, F; Buri, L; Balani, A; de Manzini, N

    2012-11-01

    Obesity is an increasing health problem worldwide. The intragastric balloon as a temporary endoscopic treatment of obesity can play an important role among the aforementioned group of obese individuals. It can also be used as a preoperative test before subjecting patients to restrictive bariatric surgery. Furthermore, the intragastric device may be applied to patients affected by severe obesity as a "bridge treatment" before they undergo major surgery in order to reduce chances of operation-related risks. To date, there are insufficient data in the literature on the long-term results of the intragastric balloon. Our study includes an analysis of our experience with Heliosphere® BAG from 2006 through to 2010, concerning early weight loss and weight loss maintenance over at least 18 months since the device's removal. The 32 patients who completed the 6-month treatment had recorded a mean weight loss of 12.66 kg and a mean overweight loss of 24.37 % (SD, 12.74). A total of 16 patients are subjected to an 18-month follow-up. Their pretreatment and long-term body mass index (BMI) were calculated: 6 months later, when devices were removed, they showed a mean weight of 99.75 kg (SD, 17.90; p < 0.001) and a mean weight loss of 13.62 kg and 26.14 % (SD, 12.79). 18 months after removing Heliosphere® BAG, the 16 patients' mean BMI was 37.28 kg/m² (SD, 5.41; p = 0.004), with a mean weight of 103.56 kg (SD 17.25; p = 0.0125), and a mean weight loss of 9.8 kg or 18.2 % (SD, 12.07). Heliosphere® BAG enables modest short-term weight loss with little side effects, although mid/long-term follow-up may entail partial weight gain. We believe it can be considered a useful bridge treatment in bariatric surgery in order to reduce chances of preoperative risks.

  13. Laparoscopic specimen retrieval bags.

    Science.gov (United States)

    Smorgick, Noam

    2014-10-01

    Specimen retrieval bags have long been used in laparoscopic gynecologic surgery for contained removal of adnexal cysts and masses. More recently, the concerns regarding spread of malignant cells during mechanical morcellation of myoma have led to an additional use of specimen retrieval bags for contained "in-bag" morcellation. This review will discuss the indications for use retrieval bags in gynecologic endoscopy, and describe the different specimen bags available to date.

  14. The Effects of a Plant Growth Regulator, Leaf Removal, Bagging, and Harvest Time on the Lipoxygenase Activity and Fatty Acid Composition of Pinot Noir Grapevines

    International Nuclear Information System (INIS)

    Ju, Y.; Zeng, J.; Zhu, M.; Lv, X.; Wang, T.; Zhang, Z.; Li, H.; Fang, Y.

    2016-01-01

    Green leaf volatiles (GLVs) are an important source of grape aromas, and lipoxygenase is a key enzyme involved in the formation of green leaf volatile substances. In addition, fatty acids are the main substrates that compose GLVs and are the main precursor compound utilized in the formation of grape aromas, which are an important index of grape quality. We examined the effects of a plant growth regulator, leaf removal, bagging, and harvest time on the lipoxygenase (LOX) activity, and the fatty acid composition of grapevines were studied. The following four experimental treatments were conducted using Pinot Noir (Vitis vinifera L.) grapevines to study the following variables: treatment with a plant growth regulator, leaf removal, fruit bagging, and harvest time. We obtained the following results. (1) 16 types of fatty acids were detected in the grape skins. The unsaturated fatty acid content consisted mainly of linoleic acid, oleic acid and palmitoleic acid; however, no linolenic acid was detected. In addition, the saturated fatty acid content consisted primarily of palmitic acid, stearic acid, behenic acid and arachidic acid. (2) Abscisic acid (ABA), methyl jasmonate (MeJA), light intensity, and harvest time appeared to effect LOX activity. (3) According to a principal component analysis (PCA) of the four treatments and the fatty acid content of the skins, ABA (concentration of 1000 mg/L), MeJA (concentrations of 100 meu mol/L, 400 meu mol/L and 800 meu mol/L) and early harvest treatment were responsible for the changes in fatty acid content. These results could be helpful in vineyard management and in improving the quality of grapes. (author)

  15. Dynamical chiral bag model

    International Nuclear Information System (INIS)

    Colanero, K.; Chu, M.-C.

    2002-01-01

    We study a dynamical chiral bag model, in which massless fermions are confined within an impenetrable but movable bag coupled to meson fields. The self-consistent motion of the bag is obtained by solving the equations of motion exactly assuming spherical symmetry. When the bag interacts with an external meson wave we find three different kinds of resonances: fermionic, geometric, and σ resonances. We discuss the phenomenological implications of our results

  16. Bags Under Eyes

    Science.gov (United States)

    Bags under eyes Overview Bags under eyes — mild swelling or puffiness under the eyes — are common as you age. With aging, the tissues around your ... space below your eyes, adding to the swelling. Bags under eyes are usually a cosmetic concern and ...

  17. APEX (Air Pollution Exercise) Volume 21: Legal References: Air Pollution Control Regulations.

    Science.gov (United States)

    Environmental Protection Agency, Research Triangle Park, NC. Office of Manpower Development.

    The Legal References: Air Pollution Control Regulations Manual is the last in a set of 21 manuals (AA 001 009-001 029) used in APEX (Air Pollution Exercise), a computerized college and professional level "real world" game simulation of a community with urban and rural problems, industrial activities, and air pollution difficulties. The manual…

  18. Cooperative activation of transcription by autoimmune regulator AIRE and CBP

    International Nuclear Information System (INIS)

    Pitkaenen, J.; Rebane, A.; Rowell, J.; Murumaegi, A.; Stroebel, P.; Moell, K.; Saare, M.; Heikkilae, J.; Doucas, V.; Marx, A.; Peterson, P.

    2005-01-01

    Autoimmune regulator (AIRE) is a transcriptional regulator that is believed to control the expression of tissue-specific genes in the thymus. Mutated AIRE is responsible for onset of the hereditary autoimmune disease APECED. AIRE is able to form nuclear bodies (NBs) and interacts with the ubiquitous transcriptional coactivator CBP. In this paper, we show that CBP and AIRE synergistically activate transcription on different promoter reporters whereas AIRE gene mutation R257X, found in APECED patients, interferes with this coactivation effect. Furthermore, the overexpression of AIRE and CBP collaboratively enhance endogenous IFNβ mRNA expression. The immunohistochemical studies suggest that CBP, depending on the balance of nuclear proteins, is a component of AIRE NBs. We also show that AIRE NBs are devoid of active chromatin and, therefore, not sites of transcription. In addition, we demonstrate by 3D analyses that AIRE and CBP, when colocalizing, are located spatially differently within AIRE NBs. In conclusion, our data suggest that AIRE activates transcription of the target genes, i.e., autoantigens in collaboration with CBP and that this activation occurs outside of AIRE NBs

  19. Breaking BAG: The Co-Chaperone BAG3 in Health and Disease.

    Science.gov (United States)

    Behl, Christian

    2016-08-01

    Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins that currently consists of six members (BAG1-6) all sharing the BAG protein domain from which the name arises. Via this domain, BAG proteins bind to the heat shock protein 70 (Hsp70), thereby acting as a co-chaperone regulating the activity of Hsp70. In addition to their antiapoptotic activity, all human BAG proteins have distinct functions in health and disease, and BAG3 in particular is the focus of many investigations. BAG3 has a modular protein domain composition offering the possibility for manifold interactions with other proteins. Various BAG3 functions are implicated in disorders including cancer, myopathies, and neurodegeneration. The discovery of its role in selective autophagy and the description of BAG3-mediated selective macroautophagy as an adaptive mechanism to maintain cellular homeostasis, under stress as well as during aging, make BAG3 a highly interesting target for future pharmacological interventions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Chiral bag model

    International Nuclear Information System (INIS)

    Musakhanov, M.M.

    1980-01-01

    The chiral bag model is considered. It is suggested that pions interact only with the surface of a quark ''bag'' and do not penetrate inside. In the case of a large bag the pion field is rather weak and goes to the linearized chiral bag model. Within that model the baryon mass spectrum, β decay axial constant, magnetic moments of baryons, pion-baryon coupling constants and their form factors are calculated. It is shown that pion corrections to the calculations according to the chiral bag model is essential. The obtained results are found to be in a reasonable agreement with the experimental data

  1. Long-term (1992-2004) record of lead, cadmium, and zinc air contamination in Warsaw, Poland: Determination by chemical analysis of moss bags and leaves of Crimean linden

    Energy Technology Data Exchange (ETDEWEB)

    Dmuchowski, Wojciech, E-mail: dmuchowski@ob.neostrada.p [Botanical Garden-Center for Conservation of Biological Diversity, Polish Academy of Sciences, 2 Prawdziwka St., 02-973 Warszawa (Poland); Warsaw University of Life Sciences-SGGW, Faculty of Agriculture and Biology, 159 Nowoursynowska St., 02-776 Warszawa (Poland); Bytnerowicz, Andrzej [US Forest Service, Pacific Southwest Research Station, 4955 Canyon Crest Drive, Riverside, CA 92507 (United States)

    2009-12-15

    Between 1992 and 2004, air contamination with lead (Pb), cadmium (Cd), and zinc (Zn) in Warsaw, Poland, was monitored annually with moss (Sphagnum fallax) bags on a network of 230 sites covering the entire city. During the study the highest contamination was near the Warszawa Steel Mill, northwestern Warsaw. Lead concentrations in moss bags decreased in time, while those of Cd and Zn did not show clear trends. Between 1994 and 2004, Pb, Cd, and Zn were also monitored in the Crimean linden (Tilia Euchlora) foliage along the main city avenue and in a northwestern warsaw park. Lead concentrations decreased more near the avenue than in the park, indicating that the phasing-out of leaded gasoline had a major effect on reduced Pb contamination in Warsaw. At the same time, foliar concentrations of Cd and Zn in both areas decreased much less. - Between 1992 and 2004, concentrations of Pb decreased, while those of Cd and Zn remained little changed in moss bags and linden foliage exposed to ambient air in Warsaw, Poland.

  2. Long-term (1992-2004) record of lead, cadmium, and zinc air contamination in Warsaw, Poland: Determination by chemical analysis of moss bags and leaves of Crimean linden

    International Nuclear Information System (INIS)

    Dmuchowski, Wojciech; Bytnerowicz, Andrzej

    2009-01-01

    Between 1992 and 2004, air contamination with lead (Pb), cadmium (Cd), and zinc (Zn) in Warsaw, Poland, was monitored annually with moss (Sphagnum fallax) bags on a network of 230 sites covering the entire city. During the study the highest contamination was near the Warszawa Steel Mill, northwestern Warsaw. Lead concentrations in moss bags decreased in time, while those of Cd and Zn did not show clear trends. Between 1994 and 2004, Pb, Cd, and Zn were also monitored in the Crimean linden (Tilia Euchlora) foliage along the main city avenue and in a northwestern warsaw park. Lead concentrations decreased more near the avenue than in the park, indicating that the phasing-out of leaded gasoline had a major effect on reduced Pb contamination in Warsaw. At the same time, foliar concentrations of Cd and Zn in both areas decreased much less. - Between 1992 and 2004, concentrations of Pb decreased, while those of Cd and Zn remained little changed in moss bags and linden foliage exposed to ambient air in Warsaw, Poland.

  3. Long-term (1992-2004) record of lead, cadmium, and zinc air contamination in Warsaw, Poland: determination by chemical analysis of moss bags and leaves of Crimean linden.

    Science.gov (United States)

    Dmuchowski, Wojciech; Bytnerowicz, Andrzej

    2009-12-01

    Between 1992 and 2004, air contamination with lead (Pb), cadmium (Cd), and zinc (Zn) in Warsaw, Poland, was monitored annually with moss (Sphagnum fallax) bags on a network of 230 sites covering the entire city. During the study the highest contamination was near the Warszawa Steel Mill, northwestern Warsaw. Lead concentrations in moss bags decreased in time, while those of Cd and Zn did not show clear trends. Between 1994 and 2004, Pb, Cd, and Zn were also monitored in the Crimean linden (Tilia Euchlora) foliage along the main city avenue and in a northwestern warsaw park. Lead concentrations decreased more near the avenue than in the park, indicating that the phasing-out of leaded gasoline had a major effect on reduced Pb contamination in Warsaw. At the same time, foliar concentrations of Cd and Zn in both areas decreased much less.

  4. Regulation of air pollution from wood-burning stoves

    DEFF Research Database (Denmark)

    Bjørner, Thomas Bue; Brandt, Jørgen; Hansen, Lars Gårn

    Air pollution is a major global challenge. Emissions from residential wood-burning stoves make a surprisingly large contribution to total air pollution related health costs. In Denmark, emissions from wood-burning stoves are calculated to cause almost 400 premature deaths each year within Denmark...... and additionally about 300 premature deaths in other parts of Europe. In this article, we present an integrated assessment of the net social benefit of different schemes for regulating wood-burning stoves including bans and taxes. The assessment uses high resolution air pollution emission inventory...

  5. B P Bag

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. B P Bag. Articles written in Bulletin of Materials Science. Volume 35 Issue 1 February 2012 pp 1-5. Structural and optical characterization of thick and thin polycrystalline diamond films deposited by microwave plasma activated CVD · S K Pradhan B Satpati B P Bag T Sharda.

  6. Charges for plastic bags : Motivational and behavioral effects

    NARCIS (Netherlands)

    Jakovcevic, Adriana; Steg, Linda; Mazzeo, Nadia; Caballero, Romina; Franco, Paul; Putrino, Natalia; Favara, Jesica

    2014-01-01

    Two field studies tested the effects of a charge for single-use plastic bags recently implemented in Buenos Aires City, Argentina. Study 1 showed a greater increase in consumers' own bag use after the charge was introduced in supermarkets where the policy was introduced, in comparison to control

  7. Radioactive Material Containment Bags

    National Research Council Canada - National Science Library

    2000-01-01

    The audit was requested by Senator Joseph I. Lieberman based on allegations made by a contractor, Defense Apparel Services, about the Navy's actions on three contracts for radioactive material containment bags...

  8. Health effects of air quality regulations in Delhi, India

    Science.gov (United States)

    Foster, Andrew; Kumar, Naresh

    2011-03-01

    This, the first systematic study, quantifies the health effects of air quality regulations in Delhi, which adopted radical measures to improve air quality, including, for example, the conversion of all commercial vehicles to compressed natural gas (CNG), and the closure of polluting industries in residential areas from 2000 to 2002. Air pollution data, collected at 113 sites (spread across Delhi and its neighboring areas) from July-December 2003, were used to compute exposure at the place of residence of 3989 subjects. A socio-economic and respiratory health survey was administered in 1576 households. This survey collected time-use, residence histories, demographic information, and direct measurements of lung function with subjects. The optimal interpolation methods were used to link air pollution and respiratory health data at the place of their residence. Resident histories, in combination with secondary data, were used to impute cumulative exposure prior to the air-quality interventions, and the effects of recent air quality measures on lung function were then evaluated. Three important findings emerge from the analysis. First, the interventions were associated with a significant improvement in respiratory health. Second, the effect of these interventions varied significantly by gender and income. Third, consistent with a causal interpretation of these results, effects were the strongest among those individuals who spend a disproportionate share of their time out-of-doors.

  9. Bag models of hadrons

    International Nuclear Information System (INIS)

    DeTar, C.E.; Donoghue, J.F.

    1983-01-01

    We believe further progress in the bag model must come from a better understanding of QCD. The bag theory is basically a simple model of the vacuum. A ''perturbative'' vacuum of finite extent is found inside the bag, while the ''true'' vacuum is found outside. The formation of the bag can be viewed as a phase change between the two types of vacuum. In what sense does QCD support this view. There have been many recent attempts to characterize the QCD vacuum. Of particular relevance to the bag model is recent work by Hansson et al. They set out to determine the structure of the vacuum wave function by using a variational argument. Their ''trial'' wave function was inspired by the bag model, but their intention was to describe general features of QCD. Their work starts from the realization that with the usual perturbative model of the vacuum a J /sup PC/ = 0 ++ glueball state can be made with m 2 ++ glueball (C. B. Thorn, unpublished), which leads to a state with m 2 < 0 when c.m. corrections are included (65). Hansson et al show that the perturbative vacuum can lower its energy by filling up with scalar glueballs. They calculate the energy of glueballs containing two and four gluons and find that the energy of the four-gluon state is higher. Therefore the vacuum energy reaches a minimum when the glueballs start to overlap

  10. Role of BAG3 in cancer progression: A therapeutic opportunity.

    Science.gov (United States)

    De Marco, Margot; Basile, Anna; Iorio, Vittoria; Festa, Michelina; Falco, Antonia; Ranieri, Bianca; Pascale, Maria; Sala, Gianluca; Remondelli, Paolo; Capunzo, Mario; Firpo, Matthew A; Pezzilli, Raffaele; Marzullo, Liberato; Cavallo, Pierpaolo; De Laurenzi, Vincenzo; Turco, Maria Caterina; Rosati, Alessandra

    2018-06-01

    BAG3 is a multifunctional protein that can bind to heat shock proteins (Hsp) 70 through its BAG domain and to other partners through its WW domain, proline-rich (PXXP) repeat and IPV (Ile-Pro-Val) motifs. Its intracellular expression can be induced by stressful stimuli, while is constitutive in skeletal muscle, cardiac myocytes and several tumour types. BAG3 can modulate the levels, localisation or activity of its partner proteins, thereby regulating major cell pathways and functions, including apoptosis, autophagy, mechanotransduction, cytoskeleton organisation, motility. A secreted form of BAG3 has been identified in studies on pancreatic ductal adenocarcinoma (PDAC). Secreted BAG3 can bind to a specific receptor, IFITM2, expressed on macrophages, and induce the release of factors that sustain tumour growth and the metastatic process. BAG3 neutralisation therefore appears to constitute a novel potential strategy in the therapy of PDAC and, possibly, other tumours. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency.

    Science.gov (United States)

    Ruparelia, Avnika A; Oorschot, Viola; Vaz, Raquel; Ramm, Georg; Bryson-Richardson, Robert J

    2014-12-01

    Mutations in the co-chaperone Bcl2-associated athanogene 3 (BAG3) can cause myofibrillar myopathy (MFM), a childhood-onset progressive muscle disease, characterized by the formation of protein aggregates and myofibrillar disintegration. In contrast to other MFM-causing proteins, BAG3 has no direct structural role, but regulates autophagy and the degradation of misfolded proteins. To investigate the mechanism of disease in BAG3-related MFM, we expressed wild-type BAG3 or the dominant MFM-causing BAG3 (BAG3(P209L)) in zebrafish. Expression of the mutant protein results in the formation of aggregates that contain wild-type BAG3. Through the stimulation and inhibition of autophagy, we tested the prevailing hypothesis that impaired autophagic function is responsible for the formation of protein aggregates. Contrary to the existing theory, our studies reveal that inhibition of autophagy is not sufficient to induce protein aggregation. Expression of the mutant protein, however, did not induce myofibrillar disintegration and we therefore examined the effect of knocking down Bag3 function. Loss of Bag3 resulted in myofibrillar disintegration, but not in the formation of protein aggregates. Remarkably, BAG3(P209L) is able to rescue the myofibrillar disintegration phenotype, further demonstrating that its function is not impaired. Together, our knockdown and overexpression experiments identify a mechanism whereby BAG3(P209L) aggregates form, gradually reducing the pool of available BAG3, which eventually results in BAG3 insufficiency and myofibrillar disintegration. This mechanism is consistent with the childhood onset and progressive nature of MFM and suggests that reducing aggregation through enhanced degradation or inhibition of nucleation would be an effective therapy for this disease.

  12. Gravitating lepton bag model

    International Nuclear Information System (INIS)

    Burinskii, A.

    2015-01-01

    The Kerr–Newman (KN) black hole (BH) solution exhibits the external gravitational and electromagnetic field corresponding to that of the Dirac electron. For the large spin/mass ratio, a ≫ m, the BH loses horizons and acquires a naked singular ring creating two-sheeted topology. This space is regularized by the Higgs mechanism of symmetry breaking, leading to an extended particle that has a regular spinning core compatible with the external KN solution. We show that this core has much in common with the known MIT and SLAC bag models, but has the important advantage of being in accordance with the external gravitational and electromagnetic fields of the KN solution. A peculiar two-sheeted structure of Kerr’s gravity provides a framework for the implementation of the Higgs mechanism of symmetry breaking in configuration space in accordance with the concept of the electroweak sector of the Standard Model. Similar to other bag models, the KN bag is flexible and pliant to deformations. For parameters of a spinning electron, the bag takes the shape of a thin rotating disk of the Compton radius, with a ring–string structure and a quark-like singular pole formed at the sharp edge of this disk, indicating that the considered lepton bag forms a single bag–string–quark system

  13. 14 CFR 1300.3 - Supplementary regulations of the Air Transportation Stabilization Board.

    Science.gov (United States)

    2010-01-01

    ... Transportation Stabilization Board. 1300.3 Section 1300.3 Aeronautics and Space AIR TRANSPORTATION SYSTEM... General § 1300.3 Supplementary regulations of the Air Transportation Stabilization Board. (a) The regulations in this part are supplemented by the regulations of the Air Transportation Stabilization Board in...

  14. The quark bag model

    International Nuclear Information System (INIS)

    Hasenfratz, P.; Kuti, J.

    1978-01-01

    The quark bag model is reviewed here with particular emphasis on spectroscopic applications and the discussion of exotic objects as baryonium, gluonium, and the quark phase of matter. The physical vacuum is pictured in the model as a two-phase medium. In normal phase of the vacuum, outside hadrons, the propagation of quark and gluon fields is forbidden. When small bubbles in a second phase are created in the medium of the normal phase with a characteristic size of one fermi, the hadron constituent fields may propagate inside the bubbles in normal manner. The bubble (bag) is stabilized against the pressure of the confined hadron constituent fields by vacuum pressure and surface tension. Inside the bag the colored quarks and gluons are governed by the equations of quantum chromodynamics. (Auth.)

  15. Better Physician's 'Black Bags'

    Science.gov (United States)

    1976-01-01

    The "black bag" is outgrowth of astronaut monitoring technology from NASA's Johnson Space Center. Technically known as the portable medical status system, a highly advanced physician's "black bag" weighs less than 30 pounds, yet contains equipment for monitoring and recording vital signs, electrocardiograms, and electroencephalograms. Liquid crystal displays are used to present 15 digits of data simultaneously for long periods of time without excessive use of battery power. Single printed circuit card contains all circuitry required to measure and display vital signs such as heart and respiration rate, temperature, and blood pressure.

  16. Reducing single-use plastic shopping bags in the USA.

    Science.gov (United States)

    Wagner, Travis P

    2017-12-01

    In the USA, local governments have the primary responsibility to manage MSW. However, local governments lack the authority to explicitly shift costs or responsibility back onto the producer for specific problem wastes. A particularly problematic waste for local governments is the single-use plastic bag. In 2014, in the USA, 103.465 billion single-use plastic shopping bags were consumed. Because of their extremely low recyclability rate, plastic bags remain a significant source of land-based litter and marine debris and impair stormwater management systems. They also reduce the effectiveness of automated recycling systems. In response, local governments increasingly have adopted a variety of measures specifically intended to reduce the store-level consumption of single-use shopping bags in 5 major categories: bans, imposition of fees and taxes, establishing minimum product design of bags, requiring consumer education, and mandating retailer take-back programs. As of September 2017, there were 271 local governments in the USA with plastic bag ordinances covering 9.7% of the nation's population. The majority (95%) of the ordinances is a ban on single-use plastic bags; 56.9% of these bans also include a mandatory fee on paper and/or reusable bags. For the fee-based ordinances, the mode is $0.10 per bag; every tax/fee ordinance allows retailers to retain some or all the collected fee. As local governments continue to increase their actions on plastic bags, 11 states have enacted laws to prohibit local governments from regulating single-use plastic bags. Because of the success with single-use bags, local governments are also enacting similar ordinances on single-use expanded polystyrene consumer products and other single-use plastic products. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Young-Hee [Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 780-714 (Korea, Republic of); Ahn, Sang-Gun [Department of Pathology, Chosun University College of Dentistry, Gwangju 501-759 (Korea, Republic of); Kim, Soo-A., E-mail: ksooa@dongguk.ac.kr [Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 780-714 (Korea, Republic of)

    2015-08-21

    Bcl2-associated athoanogene (BAG) 3 is a member of the co-chaperone BAG family. It is induced by stressful stimuli such as heat shock and heavy metals, and it regulates cellular adaptive responses against stressful conditions. In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HSF1 during heat stress. The expression level of BAG3 was induced by heat stress in HeLa cells. Interestingly, BAG3 rapidly translocalized to the nucleus upon heat stress. Immunoprecipitation assay showed that BAG3 interacts with HSF1 under normal and stressed conditions and co-translocalizes to the nucleus upon heat stress. We also demonstrated that BAG3 interacts with HSF1 via its BAG domain. Over-expression of BAG3 down-regulates the level of nuclear HSF1 by exporting it to the cytoplasm during the recovery period. Depletion of BAG3 using siRNA results in reduced nuclear HSF1 and decreased Hsp70 promoter activity. BAG3 in MEF(hsf1{sup −/−}) cells actively translocalizes to the nucleus upon heat stress suggesting that BAG3 plays a key role in the processing of the nucleocytoplasmic shuttling of HSF1 upon heat stress. - Highlights: • The expression level of BAG3 is induced by heat stress. • BAG3 translocates to the nucleus upon heat stress. • BAG3 interacts with HSF1 and co-localizes to the nucleus. • BAG3 is a key regulator for HSF1 nuclear shuttling.

  18. BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress

    International Nuclear Information System (INIS)

    Jin, Young-Hee; Ahn, Sang-Gun; Kim, Soo-A.

    2015-01-01

    Bcl2-associated athoanogene (BAG) 3 is a member of the co-chaperone BAG family. It is induced by stressful stimuli such as heat shock and heavy metals, and it regulates cellular adaptive responses against stressful conditions. In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HSF1 during heat stress. The expression level of BAG3 was induced by heat stress in HeLa cells. Interestingly, BAG3 rapidly translocalized to the nucleus upon heat stress. Immunoprecipitation assay showed that BAG3 interacts with HSF1 under normal and stressed conditions and co-translocalizes to the nucleus upon heat stress. We also demonstrated that BAG3 interacts with HSF1 via its BAG domain. Over-expression of BAG3 down-regulates the level of nuclear HSF1 by exporting it to the cytoplasm during the recovery period. Depletion of BAG3 using siRNA results in reduced nuclear HSF1 and decreased Hsp70 promoter activity. BAG3 in MEF(hsf1 −/− ) cells actively translocalizes to the nucleus upon heat stress suggesting that BAG3 plays a key role in the processing of the nucleocytoplasmic shuttling of HSF1 upon heat stress. - Highlights: • The expression level of BAG3 is induced by heat stress. • BAG3 translocates to the nucleus upon heat stress. • BAG3 interacts with HSF1 and co-localizes to the nucleus. • BAG3 is a key regulator for HSF1 nuclear shuttling

  19. Book Bag Buddies

    Science.gov (United States)

    Madden, Angie; Townsend, J. Scott; Green, Jennifer

    2011-01-01

    Children love to learn about new topics and share what they have discovered with their teachers, families, and friends. The authors designed the "Book Bag Buddies" project to give their third-grade students a chance to channel their enthusiasm and research from science investigations into writing. In this creative project, students integrated…

  20. The cloudy bag model

    International Nuclear Information System (INIS)

    Thomas, A.W.

    1981-01-01

    Recent developments in the bag model, in which the constraints of chiral symmetry are explicitly included are reviewed. The model leads to a new understanding of the Δ-resonance. The connection of the theory with current algebra is clarified and implications of the model for the structure of the nucleon are discussed

  1. Bagging Weak Predictors

    DEFF Research Database (Denmark)

    Lukas, Manuel; Hillebrand, Eric

    Relations between economic variables can often not be exploited for forecasting, suggesting that predictors are weak in the sense that estimation uncertainty is larger than bias from ignoring the relation. In this paper, we propose a novel bagging predictor designed for such weak predictor variab...

  2. Soliton Bag Model

    International Nuclear Information System (INIS)

    Wilets, L.; Bickeboeller, M.; Birse, M.C.

    1985-01-01

    A summary of recent and current research on the Soliton Bag Model is presented. The unique feature of the model, namely dynamics, is emphasized, since this permits calculation of reactions within the framework of a covariant effective Lagrangian. One gluon exchange effects are included. 17 refs., 3 figs

  3. BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress.

    Science.gov (United States)

    Jin, Young-Hee; Ahn, Sang-Gun; Kim, Soo-A

    2015-08-21

    Bcl2-associated athoanogene (BAG) 3 is a member of the co-chaperone BAG family. It is induced by stressful stimuli such as heat shock and heavy metals, and it regulates cellular adaptive responses against stressful conditions. In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HSF1 during heat stress. The expression level of BAG3 was induced by heat stress in HeLa cells. Interestingly, BAG3 rapidly translocalized to the nucleus upon heat stress. Immunoprecipitation assay showed that BAG3 interacts with HSF1 under normal and stressed conditions and co-translocalizes to the nucleus upon heat stress. We also demonstrated that BAG3 interacts with HSF1 via its BAG domain. Over-expression of BAG3 down-regulates the level of nuclear HSF1 by exporting it to the cytoplasm during the recovery period. Depletion of BAG3 using siRNA results in reduced nuclear HSF1 and decreased Hsp70 promoter activity. BAG3 in MEF(hsf1(-/-)) cells actively translocalizes to the nucleus upon heat stress suggesting that BAG3 plays a key role in the processing of the nucleocytoplasmic shuttling of HSF1 upon heat stress. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Storing Peanuts in Grain Bags

    Science.gov (United States)

    A study was executed to determine the potential of storing farmers stock peanuts and shelled peanuts for crushing in hermetically sealed grain bags. The objectives of the study were to evaluate equipment for loading and unloading the grain bags, the capacity of the grain bags, and the changes in qu...

  5. A bag with soft surface

    International Nuclear Information System (INIS)

    Il-Tong Cheon.

    1991-02-01

    The MIT bag has a sharply edged surface. It seems to be unnatural. Taking vector mesons into account, we discuss effects of a smooth surface of the bag constructed by superposition of the MIT bags with various radii on the baryon magnetic moments. (author). 9 refs, 2 figs, 2 tabs

  6. The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.

    Directory of Open Access Journals (Sweden)

    Victoria M Virador

    Full Text Available Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such as AKT, from proteasomal degradation and conferred cytoprotection against heat shock. We hypothesized that the BAG3 protein is regulated by proteolysis.Staurosporine (STS was used as a tool to test for caspase involvement in BAG3 degradation. MDA435 and HeLa human cancer cell lines exposed to STS underwent apoptosis with a concomitant time and dose-dependent loss of BAG3, suggesting the survival role of BAG3 was subject to STS regulation. zVAD-fmk or caspase 3 and 9 inhibitors provided a strong but incomplete protection of both cells and BAG3 protein. Two putative caspase cleavage sites were tested: KEVD (BAG3(E345A/D347A within the proline-rich center of BAG3 (PXXP and the C-terminal LEAD site (BAG3(E516A/D518A. PXXP deletion mutant and BAG3(E345A/D347A, or BAG3(E516A/D518A respectively slowed or stalled STS-mediated BAG3 loss. BAG3, ubiquitinated under basal growth conditions, underwent augmented ubiquitination upon STS treatment, while there was no increase in ubiquitination of the BAG3(E516A/D518A caspase-resistant mutant. Caspase and proteasome inhibition resulted in partial and independent protection of BAG3 whereas inhibitors of both blocked BAG3 degradation. STS-induced apoptosis was increased when BAG3 was silenced, and retention of BAG3 was associated with cytoprotection.BAG3 is tightly controlled by selective degradation during STS exposure. Loss of BAG3 under STS injury required sequential caspase cleavage followed by polyubiquitination and proteasomal degradation. The need for dual regulation of BAG3 in apoptosis suggests a key role for BAG3 in cancer cell resistance to apoptosis.

  7. Motivations for self-regulation: The clean air action plan

    International Nuclear Information System (INIS)

    Giuliano, Genevieve; Linder, Alison

    2013-01-01

    In the fall of 2006 the Ports of Long Beach and Los Angeles announced the Clean Air Action Plan (CAAP). Its intent was to greatly accelerate emissions reductions from port activities. The CAAP was unprecedented in several ways: it was a voluntary agreement between two competing ports; it was achieved with the cooperation of local, state and federal agencies; it promised large particulate emissions reductions along with continued port growth, and it had a price tag of $2.1 billion. What explains the Ports’ decision to implement the CAAP? We conduct a case study to explore alternative explanations for the CAAP. Using data from interviews, media, and the history of events leading up to the CAAP, we find that the CAAP was a strategic response to social and political pressures that had built up over the previous decade. Its intent was to respond to local concerns and reduce opposition to port growth. The CAAP represents an example of the potential of voluntary efforts to solve environmental problems. - Highlights: • We conduct a case study of self-regulation for emissions reduction at seaports in Southern California. • We examine motivations for implementing the Clean Air Action Plan. • We find that social and political pressures were the main motivators, with regulatory threats a contributing factor. • The Clean Air Action Plan is a powerful example of the potential of voluntary strategies

  8. 14 CFR 221.61 - Rules and regulations governing foreign air transportation.

    Science.gov (United States)

    2010-01-01

    ... governing foreign air transportation. Instead of being included in the fares tariffs, the rules and regulations governing foreign air transportation required to be filed by §§ 221.20 and 221.30 and/or... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Rules and regulations governing foreign air...

  9. Legitimization of regulatory norms: Waterfowl hunter acceptance of changing duck bag limits

    Science.gov (United States)

    Schroeder, Susan A.; Fulton, David C.; Lawrence, Jeffrey S.; Cordts, Steven D.

    2014-01-01

    Few studies have examined response to regulatory change over time, or addressed hunter attitudes about changes in hunting bag limits. This article explores Minnesota waterfowl hunters’ attitudes about duck bag limits, examining attitudes about two state duck bag limits that were initially more restrictive than the maximum set by the U.S. Fish and Wildlife Service (USFWS), but then increased to match federal limits. Results are from four mail surveys that examined attitudes about bag limits over time. Following two bag limit increases, a greater proportion of hunters rated the new bag limit “too high” and a smaller proportion rated it “too low.” Several years following the first bag limit increase, the proportion of hunters who indicated that the limit was “too high” had declined, suggesting hunter acceptance of the new regulation. Results suggest that waterfowl bag limits may represent legal norms that influence hunter attitudes and gain legitimacy over time.

  10. WW domain of BAG3 is required for the induction of autophagy in glioma cells.

    Science.gov (United States)

    Merabova, Nana; Sariyer, Ilker Kudret; Saribas, A Sami; Knezevic, Tijana; Gordon, Jennifer; Turco, M Caterina; Rosati, Alessandra; Weaver, Michael; Landry, Jacques; Khalili, Kamel

    2015-04-01

    Autophagy is an evolutionarily conserved, selective degradation pathway of cellular components that is important for cell homeostasis under healthy and pathologic conditions. Here we demonstrate that an increase in the level of BAG3 results in stimulation of autophagy in glioblastoma cells. BAG3 is a member of a co-chaperone family of proteins that associates with Hsp70 through a conserved BAG domain positioned near the C-terminus of the protein. Expression of BAG3 is induced by a variety of environmental changes that cause stress to cells. Our results show that BAG3 overexpression induces autophagy in glioma cells. Interestingly, inhibition of the proteasome caused an increase in BAG3 levels and induced autophagy. Further analysis using specific siRNA against BAG3 suggests that autophagic activation due to proteosomal inhibition is mediated by BAG3. Analyses of BAG3 domain mutants suggest that the WW domain of BAG3 is crucial for the induction of autophagy. BAG3 overexpression also increased the interaction between Bcl2 and Beclin-1, instead of disrupting them, suggesting that BAG3 induced autophagy is Beclin-1 independent. These observations reveal a novel role for the WW domain of BAG3 in the regulation of autophagy. © 2014 Wiley Periodicals, Inc.

  11. High expression of BAG3 predicts a poor prognosis in human medulloblastoma.

    Science.gov (United States)

    Yang, Dong; Zhou, Ji; Wang, Hao; Wang, Yutao; Yang, Ge; Zhang, Yundong

    2016-10-01

    Bcl2-associated athanogene 3 (BAG3), a co-chaperone of the heat shock protein (Hsp) 70, regulates various physiological and pathological processes. However, its role in human medulloblastoma has not been clarified. First of all, the expression of BAG3 was examined in formalin-fixed, paraffin-embedded specimens by immunohistochemical staining. And then, the prognostic role of BAG3 was analyzed in 51 medulloblastoma samples. Finally, the roles of BAG3 in the proliferation, migration, and invasion of Daoy medulloblastoma cell were investigated using a specific short hairpin RNA (shRNA). The expression of BAG3 in medulloblastoma tissues was higher than nontumorous samples. Furthermore, BAG3 overexpression significantly correlated with poor prognosis of patients with medulloblastoma. The overall survival and tumor-free survival in patients with BAG3 low expression were higher than high expression. Univariate and multivariate analysis showed that BAG3 overexpression was an independent prognostic marker for medulloblastoma. After the BAG3 knockdown, the Daoy cells exhibited decreased the ability to proliferate and form neurosphere. The preliminary mechanism study showed that overexpression of BAG3 might facilitate the cell cycle transition from G1 to S phase by modulating the cyclin-dependent kinase 2 (CDK2) and cyclin E expression. Additionally, we found that BAG3 might enhance the medulloblastoma cell migratory and invasive ability. In summary, BAG3 overexpression may regulate the survival and invasive properties of medulloblastoma and may serve as a potential therapy target for medulloblastoma.

  12. Comparison of storage stability of odorous VOCs in polyester aluminum and polyvinyl fluoride tedlar bags

    Science.gov (United States)

    Whole air sampling using containers such as flexible bags or rigid canisters is commonly used to collect samples of volatile organic compounds (VOC) in air. The objective of this study was to compare the stability of polyester aluminum (PEA) and polyvinyl fluoride (PVF, brand name Tedlar®) bags for ...

  13. Monopoles and bags

    International Nuclear Information System (INIS)

    Jun, J.H.

    1980-01-01

    From chapter III to chapter V properties of U(1) monopole are discussed by calculating radiative capture of an electron by a monopole, the scattering cross section of an electron by a dyon, and the bound state properties of the electron-dyon system. The Lipkin-Weisberger-Peshkin difficulty is overcome by an introduction of a small magnetic moment of the electron. In chapter VI, the linear deformation of the Prasad-Sommerfield solution of the t'Hooft Polyakov monopole is discussed, where we found all the deformed solutions analytically. In chapter VII and VIII, the question of a deformed bag and properties of an excited bag are discussed. The excited D-state is mixed with S-state to give the correct value of g/sub A/. Initially, in chapter II, energy ratios for trimuons produced through a heavy-lepton cascade decay are calculated

  14. Dimerization Products of Chloroprene are Background Contaminants Emitted from ALTEF (Polyvinylidene Difluoride) Gas Sampling Bags.

    Science.gov (United States)

    Kwak, Jae; Fan, Maomian; Martin, Jennifer A; Ott, Darrin K; Grigsby, Claude C

    2017-01-01

    Gas sampling bags have been used for collecting air samples. Tedlar bags are most commonly used, but bleed background chemicals such as N,N-dimethylacetamide and phenol. It is often necessary to remove the contaminant by flushing the bags with pure nitrogen or air. In this study, we identified four chloroprene dimerization products as background contaminants emitted from ALTEF bags that are made of a proprietary polyvinylidene difluoride (PVDF). No monomer chloroprene was detected in the bags analyzed. All of the dimers gradually increased once bags were filled with nitrogen due to diffusion from the bag surface. Flushing the bags with nitrogen reduced their concentrations, but was not effective for removing the contaminants. When the bags that had been flushed with nitrogen 5 times were left for 24 h, they increased again, indicating that the dimers were constantly emitted from the ALTEF bag surface. To our knowledge, these compounds have never been demonstrated in ALTEF or other PVDF bags. Our finding indicates that ALTEF might be incorporated with Neoprene (chloroprene-based polymer) during its manufacturing process.

  15. Determination of volatile organic compounds (VOCs) using tedlar bag/solid-phase microextraction/gas chromatography/mass spectrometry (SPME/GC/MS) in ambient and workplace air

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Hwan; Lee, Dai Woon [Yonsei Univ., Seoul (Korea, Republic of); Hwang, Seung Man; Heo, Gwi Suk [Korea Research Institute of Standards and Science, Taejon (Korea, Republic of)

    2002-03-01

    SPME techniques have proven to be very useful tools in the analysis of wide VOCs in the air. In this study, we estimated VOCs in ambient and workplace air using a Tedlar ba/SPME/GC/MS system. The calibration curve was set to be linear over the range of 1-30 ppbv. The detection limits ranged from 10 pptv 0.93 ppbv for all VOCs. Reproducibility of TO-14 target gas mixtures by SPME/GC/MS averaged at 8.8 R.S.D (%). Air toxic VOCs (hazardous air pollutants, HAPs) containing a total of forty halohydrocarbons, aromatics, and haloaro-matic carbons could be analyzed with significant accuracy, detection limit and linearity at low ppbv level. Only reactive VOCs with low molecular weight, such as chloromethane, vinylchloride, ethylchloride and 1,2-dichloro-ethane, yielded relatively poor results using this technique. In ambient air samples, ten VOCs were identified and quantified after external calibration. VOC concentration in ambient and workplace air ranged from 0.04 to 1.85 ppbv. The overall process was successfully applied to identify and quantify VOCs in ambient/workplace air.

  16. Determination of volatile organic compounds (VOCs) using tedlar bag/solid-phase microextraction/gas chromatography/mass spectrometry (SPME/GC/MS) in ambient and workplace air

    International Nuclear Information System (INIS)

    Lee, Jae Hwan; Lee, Dai Woon; Hwang, Seung Man; Heo, Gwi Suk

    2002-01-01

    SPME techniques have proven to be very useful tools in the analysis of wide VOCs in the air. In this study, we estimated VOCs in ambient and workplace air using a Tedlar ba/SPME/GC/MS system. The calibration curve was set to be linear over the range of 1-30 ppbv. The detection limits ranged from 10 pptv 0.93 ppbv for all VOCs. Reproducibility of TO-14 target gas mixtures by SPME/GC/MS averaged at 8.8 R.S.D (%). Air toxic VOCs (hazardous air pollutants, HAPs) containing a total of forty halohydrocarbons, aromatics, and haloaro-matic carbons could be analyzed with significant accuracy, detection limit and linearity at low ppbv level. Only reactive VOCs with low molecular weight, such as chloromethane, vinylchloride, ethylchloride and 1,2-dichloro-ethane, yielded relatively poor results using this technique. In ambient air samples, ten VOCs were identified and quantified after external calibration. VOC concentration in ambient and workplace air ranged from 0.04 to 1.85 ppbv. The overall process was successfully applied to identify and quantify VOCs in ambient/workplace air

  17. The regulation of hazardous air pollutants under the Clean Air Act Amendments of 1990: Effects on the Portland cement industry

    International Nuclear Information System (INIS)

    Mikols, E.H.; Gill, A.S.; Dougherty, A.

    1996-01-01

    Title III of the 1990 Clean Air Act Amendments (CAAA) addresses the control of hazardous air pollutants (HAPs) from major sources of air pollution in the US. In the CAAA, Congress defined 189 compounds as hazardous air pollutants in need of additional control by the Environmental Protection Agency (EPA). Congress directed EPA to identify the major source categories which emit HAPs and to prepare regulations that would reduce and control future HAP emissions. This paper outlines the activities undertaken by EPA to regulate HAP emissions from Portland cement plants and the program developed by the Portland cement manufacturing industry to cope with Title III

  18. Theoretical and Experimental Investigations of Highly Uprated Diesel Engine with Temperature Regulator of Supercharging Air

    Directory of Open Access Journals (Sweden)

    G. A. Vershina

    2005-01-01

    Full Text Available Mathematical model of a highly uprated diesel engine with turbo-supercharging and intercooler of supercharging air is given in die paper. Theoretical study based on the model has made it possible to design and test an intercooler with a temperature regulator of supercharging air. Test results prove efficiency of temperature regulation of supercharging air in operation of an engine at low loads with excess air factor more than 3.2.

  19. Air-Inflated Fabric Structures

    National Research Council Canada - National Science Library

    Cavallaro, Paul V; Sadegh, Ali M

    2006-01-01

    .... Examples include air ships, weather balloons, inflatable antennas and radomes, temporary shelters, pneumatic muscles and actuators, inflatable boats, temporary bridging, and energy absorbers such as automotive air bags...

  20. BAG-1 enhances cell-cell adhesion, reduces proliferation and induces chaperone-independent suppression of hepatocyte growth factor-induced epidermal keratinocyte migration

    International Nuclear Information System (INIS)

    Hinitt, C.A.M.; Wood, J.; Lee, S.S.; Williams, A.C.; Howarth, J.L.; Glover, C.P.; Uney, J.B.; Hague, A.

    2010-01-01

    Cell motility is important in maintaining tissue homeostasis, facilitating epithelial wound repair and in tumour formation and progression. The aim of this study was to determine whether BAG-1 isoforms regulate epidermal cell migration in in vitro models of wound healing. In the human epidermal cell line HaCaT, endogenous BAG-1 is primarily nuclear and increases with confluence. Both transient and stable p36-Bag-1 overexpression resulted in increased cellular cohesion. Stable transfection of either of the three human BAG-1 isoforms p36-Bag-1 (BAG-1S), p46-Bag-1 (BAG-1M) and p50-Bag-1 (BAG-1L) inhibited growth and wound closure in serum-containing medium. However, in response to hepatocyte growth factor (HGF) in serum-free medium, BAG-1S/M reduced communal motility and colony scattering, but BAG-1L did not. In the presence of HGF, p36-Bag-1 transfectants retained proliferative response to HGF with no change in ERK1/2 activation. However, the cells retained E-cadherin localisation at cell-cell junctions and exhibited pronounced cortical actin. Point mutations in the BAG domain showed that BAG-1 inhibition of motility is independent of its function as a chaperone regulator. These findings are the first to suggest that BAG-1 plays a role in regulating cell-cell adhesion and suggest an important function in epidermal cohesion.

  1. Bag model with diffuse surface

    International Nuclear Information System (INIS)

    Phatak, S.C.

    1986-01-01

    The constraint of a sharp bag boundary in the bag model is relaxed in the present work. This has been achieved by replacing the square-well potential of the bag model by a smooth scalar potential and introducing a term similar to the bag pressure term. The constraint of the conservation of the energy-momentum tensor is used to obtain an expression for the added bag pressure term. The model is then used to determine the static properties of the nucleon. The calculation shows that the rms charge radius and the nucleon magnetic moment are larger than the corresponding bag model values. Also, the axial vector coupling constant and the πNN coupling constant are in better agreement with the experimental values

  2. Dynamics of the soliton bag

    International Nuclear Information System (INIS)

    Wilets, L.; Goldflam, R.

    1983-09-01

    The MIT bag was one of the earliest and most successful models of QCD, imposing confinement and including perturbative gluon interactions. An evolution of the MIT bag came with the introduction of the chiral and cloudy bags, which treat pions as elementary particles. As a model of QCD, the soliton model proposed by Friedberg and Lee is particularly attractive. It is based on a covariant field theory and is sufficiently general so that, for certain limiting cases of the adjustable parameters, it can describe either the MIT or SLAC (string) bags. The confinement mechanism appears as a dynamic field. This allows non-static processes, such as bag oscillations and bag collisions, to be calculated utilizing the well-developed techniques of nuclear many-body theory. The utilization of the model for calculating dynamical processes is discussed. 14 references

  3. Acoustic Multipurpose Cargo Transfer Bag

    Science.gov (United States)

    Baccus, Shelley

    2015-01-01

    The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) program is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) are designed to be the same external volume as a regular cargo transfer bag, the common logistics carrier for the International Space Station. After use as a cargo bag, the MCTB can be unzipped and unfolded to be reused. This Acoustic MCTBs transform into acoustic blankets after the initial logistics carrying objective is complete.

  4. The fuzzy bag model revisited

    International Nuclear Information System (INIS)

    Pilotto, F.; Vasconcellos, C.A.Z.; Coelho, H.T.

    2001-01-01

    In this work we develop a new version of the fuzzy bag model. Th main ideas is to include the conservation of energy and momentum in the model. This feature is not included in the original formulation of the fuzzy bag model, but is of paramount importance to interpret the model as being a bag model - that, is a model in which the outward pressure of the quarks inside the bag is balanced by the inward pressure of the non-perturbative vacuum outside the bag - as opposed to a relativistic potential model, in which there is no energy-momentum conservation. In the MT bag model, as well as in the original version of the fuzzy bag model, the non-perturbative QCD vacuum is parametrized by a constant B in the Lagrangian density. One immediate consequence of including energy-momentum conservation in the fuzzy bag model is that the bag constant B will acquire a radial dependence, B = B(r). (author)

  5. The fuzzy bag model revisited

    Energy Technology Data Exchange (ETDEWEB)

    Pilotto, F.; Vasconcellos, C.A.Z. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Inst. de Fisica; Coelho, H.T. [Pernambuco Univ., Recife, PE (Brazil). Inst. de Fisica

    2001-07-01

    In this work we develop a new version of the fuzzy bag model. Th main ideas is to include the conservation of energy and momentum in the model. This feature is not included in the original formulation of the fuzzy bag model, but is of paramount importance to interpret the model as being a bag model - that, is a model in which the outward pressure of the quarks inside the bag is balanced by the inward pressure of the non-perturbative vacuum outside the bag - as opposed to a relativistic potential model, in which there is no energy-momentum conservation. In the MT bag model, as well as in the original version of the fuzzy bag model, the non-perturbative QCD vacuum is parametrized by a constant B in the Lagrangian density. One immediate consequence of including energy-momentum conservation in the fuzzy bag model is that the bag constant B will acquire a radial dependence, B = B(r). (author)

  6. Runer bag ruder

    DEFF Research Database (Denmark)

    2015-01-01

    efterhånden ses på dem. Vejr og vind har gennem tiderne sat deres præg på de enestående mindesmærker. Og de mange turister, der hvert år besøger monumentområder, kommer også helt tæt på mindesmærkerne. Så tæt at Haralds sten udsættes for et alvorligt graffitihærværk i 2011. Se med i filmen ”Runer bag ruder...

  7. Off-gas filtration and releases: bag filters

    International Nuclear Information System (INIS)

    Hennart, D.M.J.G.

    1985-01-01

    During high-temperature incineration of radioactive waste, some metal oxides are volatilized and carried out with the off-gases. During cooling those oxides react with acidic components generated by the combustion of the fuel oil or of the waste itself. This results in a submicronic crystalline dust in which cesium isotopes are concentrated. Bag filters have been selected at S.C.K./C.E.N. to carry out the first step of dust separation. Two baghouses equipped with Teflon bags with a total filtering area of 100 m 2 have been installed. The bags are cleaned on line by compressed air backflow. The residual dust content is below 3 mg/m 3 , which is sufficiently low to be removed by HEPA filters. The baghouses were put into operation in October 1981 and since then have been on line for about 3000 hours. Some bags had to be replaced after a fire in mid-1983. (orig.)

  8. The Chiral bag model and the little bag

    International Nuclear Information System (INIS)

    Vento, Vincent.

    1980-11-01

    We review the properties of the existing solutions to the Chiral bag equations of motion and discuss how the 'little bag' picture could come about in this scheme. Our analysis leads to a model which is qualitatively similar to the naive quark model with pion cloud corrections. We use this latter approach to look for pion cloud signatures in experimental data

  9. Solitons, monopoles and bags

    International Nuclear Information System (INIS)

    Rajasekaran, G.

    1978-01-01

    Recent developments in the theory of solitons and related objects in the fields of high energy physics and nuclear physics are reviewed. The aim is to concentrate on the physical aspects and explain why these objects have awakened the interest of physicists. The physics of solitons is discussed with the help of a simple one-dimensional soliton. Then the physically more interesting monopole-soliton is considered and its connection with the original Dirac monopole is pointed out. The ''revolutionary'' possibility of making fermions as composites of bosons is indicated. Both the one-dimensional solitons and the monopole-soliton are examples of ''topological solitons'' and the role of topology in the physics of solitons is explained. The possible importance of topological quantum numbers in providing a fundamental understanding of the basic conservation laws of physics is pointed out. Two examples of non-topological solitons namely, the nucleon as a bag of almost-massless quarks and the abnormal nucleons as a bag of almost massless nucleons is discussed. (auth.)

  10. HIV-1 Tat protein induces glial cell autophagy through enhancement of BAG3 protein levels.

    Science.gov (United States)

    Bruno, Anna Paola; De Simone, Francesca Isabella; Iorio, Vittoria; De Marco, Margot; Khalili, Kamel; Sariyer, Ilker Kudret; Capunzo, Mario; Nori, Stefania Lucia; Rosati, Alessandra

    2014-01-01

    BAG3 protein has been described as an anti-apoptotic and pro-autophagic factor in several neoplastic and normal cells. We previously demonstrated that BAG3 expression is elevated upon HIV-1 infection of glial and T lymphocyte cells. Among HIV-1 proteins, Tat is highly involved in regulating host cell response to viral infection. Therefore, we investigated the possible role of Tat protein in modulating BAG3 protein levels and the autophagic process itself. In this report, we show that transfection with Tat raises BAG3 levels in glioblastoma cells. Moreover, BAG3 silencing results in highly reducing Tat- induced levels of LC3-II and increasing the appearance of sub G0/G1 apoptotic cells, in keeping with the reported role of BAG3 in modulating the autophagy/apoptosis balance. These results demonstrate for the first time that Tat protein is able to stimulate autophagy through increasing BAG3 levels in human glial cells.

  11. Vapor pressure measured with inflatable plastic bag

    Science.gov (United States)

    1965-01-01

    Deflated plastic bag in a vacuum chamber measures initial low vapor pressures of materials. The bag captures the test sample vapors and visual observation of the vapor-inflated bag under increasing external pressures yields pertinent data.

  12. Bag pigtråd

    DEFF Research Database (Denmark)

    Bjerre, Jacob Halvas

    2015-01-01

    BogFeature om Inger Bjørn Knudsen: Bag Pigtråd - Rom flygtningelejr 1945-1948. Udg. af Lemvig Museum, 2014. 80 sider......BogFeature om Inger Bjørn Knudsen: Bag Pigtråd - Rom flygtningelejr 1945-1948. Udg. af Lemvig Museum, 2014. 80 sider...

  13. Fun and Functional Shopping Bags

    Science.gov (United States)

    Owen, Barbara Downing

    2009-01-01

    In conjunction with her school's interest in becoming more "green," this author designed an art project using inexpensive, sturdy, reusable grocery bags. In this article, she describes the different design concepts and art media used by each grade in decorating these bags. (Contains 1 online resource.)

  14. Detecting leaks in vacuum bags

    Science.gov (United States)

    Carlstrom, E. E.

    1980-01-01

    Small leaks in vacuum bag can be readily detected by eye, using simple chemical reaction: combination of ammonia and acetic acid vapors to produce cloudy white smoke. Technique has been successfully used to test seam integrity and to identify minute pinholes in vacuum bag used in assembly of ceramic-tile heat shield for Space Shuttle Orbiter.

  15. Sensory Pollution from Bag Filters, Carbon Filters and Combinations

    DEFF Research Database (Denmark)

    Bekö, Gabriel; Clausen, Geo; Weschler, Charles J.

    2008-01-01

    by an upstream pre-filter (changed monthly), an EU7 filter protected by an upstream activated carbon (AC) filter, and EU7 filters with an AC filter either downstream or both upstream and downstream. In addition, two types of stand-alone combination filters were evaluated: a bag-type fiberglass filter...... that contained AC and a synthetic fiber cartridge filter that contained AC. Air that had passed through used filters was most acceptable for those sets in which an AC filter was used downstream of the particle filter. Comparable air quality was achieved with the stand-alone bag filter that contained AC...

  16. Pions and the chiral bag

    International Nuclear Information System (INIS)

    Rho, M.

    1982-01-01

    As an aid to discussing the structure of nucleons and nuclei conceptual framework, heuristic arguments are presented which indicate that a hadron can be considered as a bag consisting of two different phases. The chiral structure of the phase outside the bag is discussed in terms of effective field theories and it is shown to what extent experiments in nuclei can constrain the structure of such theories. Results thus obtained are then combined to set up a set of equations for the bag structure of u and d hadrons, incorporating asymptotic freedom in the phase inside of the bag confinement of quarks and gluons by boundary conditions and spontaneously broken chiral symmetry in the outside. This set of equations which represent a chirally invariant generalization of the M.I.T. bag model is then solved. (U.K.)

  17. Interaction of regulation and innovation: Solar air heating collectors

    OpenAIRE

    Kramer, K.

    2012-01-01

    Solar Air Heating Collectors have still a very small share of 0.8% of the nominal installed capacity in the solar heating and cooling market (151.7 GWth) [1]. Although constituting a niche market, the potential of those kind of collectors to provide heat for industrial processes, processing food, room heating, air preheating, drying processes or air conditioning could be significant. However, the technical potentials of the various technological solutions are not easy to compare. Such a compa...

  18. BAG1: the guardian of anti-apoptotic proteins in acute myeloid leukemia.

    Directory of Open Access Journals (Sweden)

    Sanja Aveic

    Full Text Available BCL2 associated Athano-Gene 1 (BAG1 is a multifunctional protein that has been described to be involved in different cell processes linked to cell survival. It has been reported as deregulated in diverse cancer types. Here, BAG1 protein was found highly expressed in children with acute myeloid leukemia at diagnosis, and in a cohort of leukemic cell lines. A silencing approach was used for determining BAG1's role in AML, finding that its down-regulation decreased expression of BCL2, BCL-XL, MCL1, and phospho-ERK1/2, all proteins able to sustain leukemia, without affecting the pro-apoptotic protein BAX. BAG1 down-regulation was also found to increase expression of BAG3, whose similar activity was able to compensate the loss of function of BAG1. BAG1/BAG3 co-silencing caused an enhanced cell predisposition to death in cell lines and also in primary AML cultures, affecting the same proteins. Cell death was CASPASE-3 dependent, was accompanied by PARP cleavage and documented by an increased release of pro-apoptotic molecules Smac/DIABLO and Cytochrome c. BAG1 was found to directly maintain BCL2 and to protect MCL1 from proteasomal degradation by controlling USP9X expression, which appeared to be its novel target. Finally, BAG1 was found able to affect leukemia cell fate by influencing the expression of anti-apoptotic proteins crucial for AML maintenance.

  19. Identification of control parameters for the sulfur gas storability with bag sampling methods

    Science.gov (United States)

    Air samples containing sulfur compounds are often collected and stored in sample bags prior to analyses. The storage stability of six gaseous sulfur compounds (H2S, CH3SH, DMS, CS2, DMDS and SO2) was compared between two different bag materials (polyvinyl fluoride (PVF) and polyester aluminum (PEA))...

  20. Peepoo bag: self-sanitising single use biodegradable toilet.

    Science.gov (United States)

    Vinnerås, Björn; Hedenkvist, Mikael; Nordin, Annika; Wilhelmson, Anders

    2009-01-01

    Unsafe water, sanitation and hygiene together with deficient nutritional status are major contributors to the global burden of disease. Safe collection, disposal and reuse of human excreta would enable the risk of transmission of diseases to be decreased and household food security to be increased in many regions. However, the majority of the 2.5 billion people lacking improved sanitation comprise poor people in societies with weak infrastructure. This study developed a low cost sanitation option requiring little investment and maintenance--a single use, self-sanitising, biodegradable toilet (Peepoo bag) and tested it for smell, degradability and hygiene aspects. It was found that no smell was detectable from a 25 microm thick bag filled with faeces during 24 h in a 10 m2 room at 30 degrees C. Bags that had been in contact with urea-treated faeces or urine for 2 months in air, compost or water at 24 or 37 degrees C showed little signs of degradation. Furthermore, pathogen inactivation modelling of the 4 g of urea present in the bag indicated that appropriate sanitation of faecal material collected is achieved in the bag within 2-4 weeks, after which the bag can be degraded and reused as fertiliser.

  1. A bag adapted for the handling of a filtering element or filter unit

    International Nuclear Information System (INIS)

    Marshall, D.A.G.

    1980-01-01

    The invention relates to a transparent, flexible, synthetic plastics bag adapted to contain a filter element or filter unit so that the latter can be inserted into or removed from a filter casing or duct while being contained in the bag. The bag has a neck portion which is capable of being removably secured in an air-tight manner on to a part of the casing, and gloves or glove portions are provided in, or are formed in, the wall of the bag to permit handles on the filter element or unit to be grasped. (author)

  2. Development of Spray on Bag for manufacturing of large composites parts: Diffusivity analysis

    Science.gov (United States)

    Dempah, Maxime Joseph

    Bagging materials are utilized in many composites manufacturing processes. The selection is mainly driven by cost, temperature requirements, chemical compatibility and tear properties of the bag. The air barrier properties of the bag are assumed to be adequate or in many cases are not considered at all. However, the gas barrier property of a bag is the most critical parameter, as it can negatively affect the quality of the final laminate. The barrier property is a function of the bag material, uniformity, thickness and temperature. Improved barrier properties are needed for large parts, high pressure consolidated components and structures where air stays entrapped on the part surface. The air resistance property of the film is defined as permeability and is investigated in this thesis. A model was developed to evaluate the gas transport through the film and an experimental cell was implemented to characterize various commercial films. Understanding and characterizing the transport phenomena through the film allows optimization of the bagging material for various manufacturing processes. Spray-on-Bag is a scalable alternative bagging method compared to standard films. The approach allows in-situ fabrication of the bag on large and complex geometry structures where optimization of the bag properties can be varied on a local level. An experimental setup was developed and implemented using a six axis robot and an automated spraying system. Experiments were performed on a flat surface and specimens were characterized and compared to conventional films. Air barrier properties were within range of standard film approaches showing the potential to fabricate net shape bagging structures in an automated process.

  3. Some impacts of the 1990 Clean Air Act and state clean-air regulations on the fertilizer industry

    International Nuclear Information System (INIS)

    Breed, C.E.; Kerns, O.S.

    1992-01-01

    The Clean Air Act amendments of 1990 will intensify national efforts to reduce air pollution. They will have major impacts on governmental agencies and on industrial and commercial facilities throughout the country. As with other industries, it is essential for fertilizer dealers and producers to understand how these changes to the Clean Air Act can significantly change the way they do business. This paper is proffered as an overview of ways in which the 1990 amendments to the Clean Air Act may impact the fertilizer industry. The nonattainment, toxics, and permit provisions of the amended act will be three areas of particular concern to the fertilizer industry. Implementation of the new regulatory requirements of this legislation promises to be a long and onerous process for all concerned. However, it appears that state and local regulations may have a much more profound impact on the fertilizer industry than the new Clean Air Act

  4. ARE PLASTIC GROCERY BAGS SACKING THE ENVIRONMENT?

    OpenAIRE

    Mangal Gogte

    2009-01-01

    This paper is oriented on analysis impacts of plastic bags on environment. In this paper is analyzed did plastic bags are so harmful, and what are the main ingredients of it. One part of this paper is oriented on effects of plastic bags and management of their usage. There is also made comparative analysis between impacts of plastic and paper bags on environment.

  5. 21 CFR 878.4100 - Organ bag.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Organ bag. 878.4100 Section 878.4100 Food and... GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4100 Organ bag. (a) Identification. An organ bag is a device that is a flexible plastic bag intended to be used as a temporary receptacle for an...

  6. BAG3: a new player in the heart failure paradigm.

    Science.gov (United States)

    Knezevic, Tijana; Myers, Valerie D; Gordon, Jennifer; Tilley, Douglas G; Sharp, Thomas E; Wang, JuFang; Khalili, Kamel; Cheung, Joseph Y; Feldman, Arthur M

    2015-07-01

    BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle but can also be found in the brain and in the peripheral nervous system. BAG3 functions in the cell include: serving as a co-chaperone with members of the heat-shock protein family of proteins to facilitate the removal of misfolded and degraded proteins, inhibiting apoptosis by interacting with Bcl2 and maintaining the structural integrity of the Z-disk in muscle by binding with CapZ. The importance of BAG3 in the homeostasis of myocytes and its role in the development of heart failure was evidenced by the finding that single allelic mutations in BAG3 were associated with familial dilated cardiomyopathy. Furthermore, significant decreases in the level of BAG3 have been found in end-stage failing human heart and in animal models of heart failure including mice with heart failure secondary to trans-aortic banding and in pigs after myocardial infarction. Thus, it becomes relevant to understand the cellular biology and molecular regulation of BAG3 expression in order to design new therapies for the treatment of patients with both hereditary and non-hereditary forms of dilated cardiomyopathy.

  7. Bagging constrained equity premium predictors

    DEFF Research Database (Denmark)

    Hillebrand, Eric; Lee, Tae-Hwy; Medeiros, Marcelo

    2014-01-01

    The literature on excess return prediction has considered a wide array of estimation schemes, among them unrestricted and restricted regression coefficients. We consider bootstrap aggregation (bagging) to smooth parameter restrictions. Two types of restrictions are considered: positivity of the r...

  8. Visual problem solving and self-regulation in training air traffic control

    NARCIS (Netherlands)

    Van Meeuwen, Ludo

    2013-01-01

    Van Meeuwen, L. W. (2013). Visual problem solving and self-regulation in training air traffic control (Unpublished doctoral dissertation). Centre for Learning Sciences and Technologies, Open Universiteit, Heerlen, The Netherlands.

  9. Visual Problem Solving and Self‐regulation in Training Air Traffic Control

    NARCIS (Netherlands)

    Meeuwen van, Ludo

    2015-01-01

    Van Meeuwen, L. W. (2013). Visual problem solving and self-regulation in training air traffic control (Unpublished doctoral dissertation). Centre for Learning Sciences and Technologies, Open Universiteit, Heerlen, The Netherlands.

  10. Silencing of BAG3 inhibits the epithelial-mesenchymal transition in human cervical cancer.

    Science.gov (United States)

    Song, Fei; Wang, Geng; Ma, Zhifang; Ma, Yuebing; Wang, Yingying

    2017-11-10

    Bcl2-associated athanogene 3 (BAG3) has been reported to be involved in aggressive progression of many tumors. In the present study, we examined the expression of BAG3 in human cervical cancer (CC) tissues and investigated the role of BAG3 in SiHa and HeLa cell growth, migration, and invasion. Here, we found that most of CC tissues highly expressed the protein and mRNA of BAG3, while their expression was obviously lower in paired normal tissues (all pBAG3 expression was associated with FIGO stage and metastasis (all pBAG3 siRNAs inhibited SiHa and HeLa cell growth, invasion and migration. Mechanically, BAG3 siRNAs inhibited the expression of EMT-regulating markers, involving MMP2, Slug and N-cadherin, and increased the expression of E-cadherin. In a xenograft nude model, BAG3 siRNAs inhibited tumor growth and the expression of EMT biomarkers. In conclusion, BAG3 is involved in the EMT process, including cell growth, invasion and migration in the development of CC. Thus, BAG3 target might be recommended as a novel therapeutic approach.

  11. BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78.

    Science.gov (United States)

    Kong, De-Hui; Zhang, Qiang; Meng, Xin; Zong, Zhi-Hong; Li, Chao; Liu, Bao-Qin; Guan, Yifu; Wang, Hua-Qin

    2013-12-01

    Bcl-2 associated athanogene 3 (BAG3) has a modular structure that contains a BAG domain, a WW domain, a proline-rich (PxxP) domain to mediate potential interactions with chaperons and other proteins that participate in more than one signal transduction. In search for novel interacting partners, the current study identified that 78kDa glucose-regulated protein (GRP78) was a novel partner interacting with BAG3. Interaction between GRP78 and BAG3 was confirmed by coimmunoprecipitation and glutathione S-transferase (GST) pulldown. We also identified that the ATPase domain of GRP78 and BAG domain of BAG3 mediated their interaction. Counterintuitive for a prosurvival protein, BAG3 was found to promote the cytotoxicity of breast cancer MCF7, thyroid cancer FRO and glioma U87 cells subjected to genotoxic stress. In addition, the current study demonstrated that BAG3 interfered with the formation of the antiapoptotic GRP78-procaspase-7 complex, which resulted in an increased genotoxic stress-induced cytotoxicity in cancer cells. Furthermore, overexpression of GRP78 significantly blocked the enhancing effects of BAG3 on activation of caspase-7 and induction of apoptosis by genotoxic stress. Overall, these results suggested that through direct interaction BAG3 could prevent the antiapoptotic effect of GRP78 upon genotoxic stress. © 2013.

  12. Quantum chromodynamics, chiral symmetry and bag models

    International Nuclear Information System (INIS)

    Soyeur, M.

    1983-08-01

    This course deals with the following subjects: quarks; quantum chromodynamics (the classical Lagrangian of QCD, quark masses, the classical equations of motion of QCD, general properties, lattices); chiral symmetry (massless free Dirac theory, realizations, the σ-model); the M.I.T. bag model (basic assumptions and equations of motion, spherical cavity approximation, properties of hadrons); the chiral bag models (basic assumptions, the cloudy bag model, the little bag model); non-topological soliton bag models

  13. Quark structure of nucleons: the third bag

    International Nuclear Information System (INIS)

    Wilets, L.

    1983-01-01

    The soliton bag model proposed by Friedberg and Lee is discussed. Unlike the other bag models, it treats the confining bag as a fully dynamical object. A scalar soliton field is introduced to effect confinement. The combined quark-soliton system (plus gluons, Higgs fields, counter terms) is described by a Hamiltonian or Lagrangian. The standard bag models do not have a complete Hamiltonian or Lagrangian. The resulting bag can undergo oscillations, rotations and dynamical distortions

  14. BAG3 role in cardiomyocytes physiopathology

    OpenAIRE

    De Marco, Margot

    2013-01-01

    2010 - 2011 The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful stimuli. We found that BAG3 is upregulated during the differentiation of cardiomyoblasts. Our results prompted us to verify whether bag3 silencing could affect the differentiation state of cardiocytes and we found that bag3 silencing resulted in highly reducing ...

  15. 33 CFR 165.1319 - Safety Zone Regulations, Seafair Blue Angels Air Show Performance, Seattle, WA.

    Science.gov (United States)

    2010-07-01

    ... Blue Angels Air Show Performance, Seattle, WA. 165.1319 Section 165.1319 Navigation and Navigable... Thirteenth Coast Guard District § 165.1319 Safety Zone Regulations, Seafair Blue Angels Air Show Performance... Peninsula; thence northerly along the shore of Mercer Island to the point of origin. [Datum: NAD 1983] (c...

  16. Exploring Faraday's Law of Electrolysis Using Zinc-Air Batteries with Current Regulative Diodes

    Science.gov (United States)

    Kamata, Masahiro; Paku, Miei

    2007-01-01

    Current regulative diodes (CRDs) are applied to develop new educational experiments on Faraday's law by using a zinc-air battery (PR2330) and a resistor to discharge it. The results concluded that the combination of zinc-air batteries and the CRD array is simpler, less expensive, and quantitative and gives accurate data.

  17. 40 CFR Appendix L to Part 51 - Example Regulations for Prevention of Air Pollution Emergency Episodes

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Example Regulations for Prevention of Air Pollution Emergency Episodes L Appendix L to Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Pt. 51, App. L Appendix L to Par...

  18. Testing odorants recovery from a novel metallized fluorinated ethylene propylene gas sampling bag.

    Science.gov (United States)

    Zhu, Wenda; Koziel, Jacek A; Cai, Lingshuang; Wright, Donald; Kuhrt, Fred

    2015-12-01

    Industry-standard Tedlar bags for odor sample collection from confined animal feeding operations (CAFOs) have been challenged by the evidence of volatile organic compound (VOC) losses and background interferences. Novel impermeable aluminum foil with a thin layer of fluorinated ethylene propylene (FEP) film on the surface that is in contact with a gas sample was developed to address this challenge. In this research, Tedlar and metallized FEP bags were compared for (a) recoveries of four characteristic CAFO odorous VOCs (ethyl mercaptan, butyric acid, isovaleric acid and p-cresol) after 30 min and 24 hr sample storage time and for (b) chemical background interferences. All air sampling and analyses were performed with solid-phase microextraction (SPME) followed by gas chromatography-mass spectroscopy (GC-MS). Mean target gas sample recoveries from metallized FEP bags were 25.9% and 28.0% higher than those in Tedlar bags, for 30 min and 24 hr, respectively. Metallized FEP bags demonstrated the highest p-cresol recoveries after 30-min and 24-hr storage, 96.1±44.5% and 44.8±10.2%, respectively, among different types of sampling bags reported in previous studies. However, a higher variability was observed for p-cresol recovery with metallized FEP bags. A 0% recovery of ethyl mercaptan was observed with Tedlar bags after 24-hr storage, whereas an 85.7±7.4% recovery was achieved with metallized FEP bags. Recoveries of butyric and isovaleric acids were similar for both bag types. Two major impurities in Tedlar bags' background were identified as N,N-dimethylacetamide and phenol, while backgrounds of metallized FEP bags were significantly cleaner. Reusability of metallized FEP bags was tested. Caution is advised when using polymeric materials for storage of livestock-relevant odorous volatile organic compounds. The odorants loss with storage time confirmed that long-term storage in whole-air form is ill advised. A focused short-term odor sample containment should be

  19. Maryland air toxics regulation applicable to a natural gas compressor station

    International Nuclear Information System (INIS)

    Weidemann, H.A.; Hoffman, P.M.

    1992-01-01

    Columbia Gas Transmission Corporation submitted an air permit application to the Maryland Department of the Environment to construct a natural gas compressor station near Rutledge, Maryland. The station consists of three natural gas-fueled internal combustion reciprocating engines, each rated at 3200 horsepower. Maximum potential pollutant emissions associated with the station operation did not trigger Prevention of Significant Deterioration review or nonattainment area New Source review. However, a minor source air permit cannot be issued without addressing Maryland's toxic air regulations. Columbia initiated a detailed investigation of toxic air pollutants, including a stack test of an identical engine. Based on this information, the proposed station was subject to the toxic air regulation for acetaldehyde, acrolein, benzene, crotonaldehyde, and formaldehyde. Compliance with the toxic air regulation for crotonaldehyde was demonstrated by having an emission rate less than the threshold emission rate, specified in the regulation. The ambient air quality impact of the other four pollutants was determined using the Industrial Source Complex dispersion model and resulted in predicted concentrations below the pollutant-specific acceptable ambient level. A carcinogenic impact analysis was performed for acetaldehyde, benzene, and formaldehyde to demonstrate compliance with the accepted risk of one in one hundred thousand

  20. Quark bag coupling to finite size pions

    International Nuclear Information System (INIS)

    De Kam, J.; Pirner, H.J.

    1982-01-01

    A standard approximation in theories of quark bags coupled to a pion field is to treat the pion as an elementary field ignoring its substructure and finite size. A difficulty associated with these treatments in the lack of stability of the quark bag due to the rapid increase of the pion pressure on the bad as the bag size diminishes. We investigate the effects of the finite size of the qanti q pion on the pion quark bag coupling by means of a simple nonlocal pion quark interaction. With this amendment the pion pressure on the bag vanishes if the bag size goes to zero. No stability problems are encountered in this description. Furthermore, for extended pions, no longer a maximum is set to the bag parameter B. Therefore 'little bag' solutions may be found provided that B is large enough. We also discuss the possibility of a second minimum in the bag energy function. (orig.)

  1. BAG3 down-modulation reduces anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein.

    Science.gov (United States)

    Chiappetta, Gennaro; Basile, Anna; Arra, Claudio; Califano, Daniela; Pasquinelli, Rosa; Barbieri, Antonio; De Simone, Veronica; Rea, Domenica; Giudice, Aldo; Pezzullo, Luciano; De Laurenzi, Vincenzo; Botti, Gerardo; Losito, Simona; Conforti, Daniela; Turco, Maria Caterina

    2012-01-01

    Anaplastic thyroid tumors (ATC) express high levels of BAG3, a member of the BAG family of cochaperone proteins that is involved in regulating cell apoptosis through multiple mechanisms. The objective of the study was the investigation of the influence of B-cell lymphoma-2-associated athanogene 3 (BAG3) on ATC growth. We investigated the effects of BAG3 down-modulation, obtained by using a specific small interfering RNA, on in vitro and in vivo growth of the human ATC cell line 8505C. Because BRAF protein plays an important role in ATC cell growth, we analyzed the effects of BAG3 down-modulation on BRAF protein levels. Furthermore, by using a proteasome inhibitor, we verified whether BAG3-mediated regulation of BRAF levels involved a proteasome-dependent mechanism. BAG3 down-modulation significantly inhibits ATC growth in vitro and in vivo. BAG3 coimmunoprecipitates with BRAF protein, and its down-modulation results in a significant reduction of BRAF protein levels, which can be reverted by incubation with the proteasome inhibitor MG132. BAG3 protein sustains ATC growth in vitro and in vivo. The underlying molecular mechanism appears to rely on BAG3 binding to BRAF, thus protecting it from proteasome-dependent degradation. These results are in line with the reported ability of BAG3 to interfere with the proteasomal delivery of a number of other client proteins.

  2. Navajo Generating Station and Air Visibility Regulations: Alternatives and Impacts

    Energy Technology Data Exchange (ETDEWEB)

    Hurlbut, D. J.; Haase, S.; Brinkman, G.; Funk, K.; Gelman, R.; Lantz, E.; Larney, C.; Peterson, D.; Worley, C.; Liebsch, E.

    2012-01-01

    Pursuant to the Clean Air Act, the U.S. Environmental Protection Agency (EPA) announced in 2009 its intent to issue rules for controlling emissions from Navajo Generating Station that could affect visibility at the Grand Canyon and at several other national parks and wilderness areas. The final rule will conform to what EPA determines is the best available retrofit technology (BART) for the control of haze-causing air pollutants, especially nitrogen oxides. While EPA is ultimately responsible for setting Navajo Generating Station's BART standards in its final rule, it will be the U.S. Department of the Interior's responsibility to manage compliance and the related impacts. This study aims to assist both Interior and EPA by providing an objective assessment of issues relating to the power sector.

  3. Double Vacuum Bag Process for Resin Matrix Composite Manufacturing

    Science.gov (United States)

    Hou, Tan-Hung (Inventor); Jensen, Brian J. (Inventor)

    2007-01-01

    A double vacuum bag molding assembly with improved void management and laminate net shape control which provides a double vacuum enviromnent for use in fabricating composites from prepregs containing air and/or volatiles such as reactive resin matrix composites or composites from solvent containing prepregs with non-reactive resins matrices. By using two vacuum environments during the curing process, a vacuum can be drawn during a B-stage of a two-step cycle without placing the composite under significant relative pressure. During the final cure stage, a significant pressure can be applied by releasing the vacuum in one of the two environments. Inner and outer bags are useful for creating the two vacuum environments with a perforated tool intermediate the two. The composite is placed intermediate a tool plate and a caul plate in the first environment with the inner bag and tool plate defining the first environment. The second environment is characterized by the outer bag which is placed over the inner bag and the tool plate.

  4. The Multifunctional Protein BAG3

    Directory of Open Access Journals (Sweden)

    Valerie D. Myers, MS

    2018-02-01

    Full Text Available The B-cell lymphoma 2–associated anthanogene (BAG3 protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins in facilitating autophagy; binds to B-cell lymphoma 2, resulting in inhibition of apoptosis; attaches actin to the Z disk, providing structural support for the sarcomere; and links the α-adrenergic receptor with the L-type Ca2+ channel. When BAG3 is overexpressed in cancer cells, it facilitates prosurvival pathways that lead to insensitivity to chemotherapy, metastasis, cell migration, and invasiveness. In contrast, in the heart, mutations in BAG3 have been associated with a variety of phenotypes, including both hypertrophic/restrictive and dilated cardiomyopathy. In murine skeletal muscle and vasculature, a mutation in BAG3 leads to critical limb ischemia after femoral artery ligation. An understanding of the biology of BAG3 is relevant because it may provide a therapeutic target in patients with both cardiac and skeletal muscle disease.

  5. Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis.

    Science.gov (United States)

    Galdiero, Francesca; Bello, Anna Maria; Spina, Anna; Capiluongo, Anna; Liuu, Sophie; De Marco, Margot; Rosati, Alessandra; Capunzo, Mario; Napolitano, Maria; Vuttariello, Emilia; Monaco, Mario; Califano, Daniela; Turco, Maria Caterina; Chiappetta, Gennaro; Vinh, Joëlle; Chiappetta, Giovanni

    2018-01-30

    BAG3 protein is an apoptosis inhibitor and is highly expressed in Anaplastic Thyroid Cancer. We investigated the entire set of proteins modulated by BAG3 silencing in the human anaplastic thyroid 8505C cancer cells by using the Stable-Isotope Labeling by Amino acids in Cell culture strategy combined with mass spectrometry analysis. By this approach we identified 37 up-regulated and 54 down-regulated proteins in BAG3-silenced cells. Many of these proteins are reportedly involved in tumor progression, invasiveness and resistance to therapies. We focused our attention on an oncogenic protein, CAV1, and a tumor suppressor protein, SERPINB2, that had not previously been reported to be modulated by BAG3. Their expression levels in BAG3-silenced cells were confirmed by qRT-PCR and western blot analyses, disclosing two novel targets of BAG3 pro-tumor activity. We also examined the dataset of proteins obtained by the quantitative proteomics analysis using two tools, Downstream Effect Analysis and Upstream Regulator Analysis of the Ingenuity Pathways Analysis software. Our analyses confirm the association of the proteome profile observed in BAG3-silenced cells with an increase in cell survival and a decrease in cell proliferation and invasion, and highlight the possible involvement of four tumor suppressor miRNAs and TP53/63 proteins in BAG3 activity.

  6. Translational invariance in bag model

    International Nuclear Information System (INIS)

    Megahed, F.

    1981-10-01

    In this thesis, the effect of restoring the translational invariance to an approximation to the MIT bag model on the calculation of deep inelastic structure functions is investigated. In chapter one, the model and its major problems are reviewed and Dirac's method of quantisation is outlined. This method is used in chapter two to quantise a two-dimensional complex scalar bag and formal expressions for the form factor and the structure functions are obtained. In chapter three, the expression for the structure function away from the Bjorken limit is studied. The corrections to the L 0 - approximation to the structure function is calculated in chapter four and it is shown to be large. Finally, in chapter five, a bag-like model for kinematic corrections to structure functions is introduced and agreement with data between 2 and 6 (GeV/C) 2 is obtained. (author)

  7. Reviews Toy: Air swimmers Book: Their Arrows will Darken the Sun: The Evolution and Science of Ballistics Book: Physics Experiments for your Bag Book: Quantum Physics for Poets Equipment: SEP colour wheel kit Equipment: SEP colour mixing kit Software: USB DrDAQ App: iHandy Level Equipment: Photonics Explorer kit Web Watch

    Science.gov (United States)

    2012-01-01

    WE RECOMMEND Air swimmers Helium balloon swims like a fish Their Arrows will Darken the Sun: The Evolution and Science of Ballistics Ballistics book hits the spot Physics Experiments for your Bag Handy experiments for your lessons Quantum Physics for Poets Book shows the economic importance of physics SEP colour wheel kit Wheels investigate colour theory SEP colour mixing kit Cheap colour mixing kit uses red, green and blue LEDs iHandy Level iPhone app superbly measures angles Photonics Explorer kit Free optics kit given to schools WORTH A LOOK DrDAQ DrDAQ software gets an upgrade WEB WATCH Websites show range of physics

  8. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

    Science.gov (United States)

    Judge, Luke M; Perez-Bermejo, Juan A; Truong, Annie; Ribeiro, Alexandre Js; Yoo, Jennie C; Jensen, Christina L; Mandegar, Mohammad A; Huebsch, Nathaniel; Kaake, Robyn M; So, Po-Lin; Srivastava, Deepak; Pruitt, Beth L; Krogan, Nevan J; Conklin, Bruce R

    2017-07-20

    Molecular chaperones regulate quality control in the human proteome, pathways that have been implicated in many diseases, including heart failure. Mutations in the BAG3 gene, which encodes a co-chaperone protein, have been associated with heart failure due to both inherited and sporadic dilated cardiomyopathy. Familial BAG3 mutations are autosomal dominant and frequently cause truncation of the coding sequence, suggesting a heterozygous loss-of-function mechanism. However, heterozygous knockout of the murine BAG3 gene did not cause a detectable phenotype. To model BAG3 cardiomyopathy in a human system, we generated an isogenic series of human induced pluripotent stem cells (iPSCs) with loss-of-function mutations in BAG3. Heterozygous BAG3 mutations reduced protein expression, disrupted myofibril structure, and compromised contractile function in iPSC-derived cardiomyocytes (iPS-CMs). BAG3-deficient iPS-CMs were particularly sensitive to further myofibril disruption and contractile dysfunction upon exposure to proteasome inhibitors known to cause cardiotoxicity. We performed affinity tagging of the endogenous BAG3 protein and mass spectrometry proteomics to further define the cardioprotective chaperone complex that BAG3 coordinates in the human heart. Our results establish a model for evaluating protein quality control pathways in human cardiomyocytes and their potential as therapeutic targets and susceptibility factors for cardiac drug toxicity.

  9. High capacity for extracellular acid-base regulation in the air-breathing fish Pangasianodon hypophthalmus.

    Science.gov (United States)

    Damsgaard, Christian; Gam, Le Thi Hong; Tuong, Dang Diem; Thinh, Phan Vinh; Huong Thanh, Do Thi; Wang, Tobias; Bayley, Mark

    2015-05-01

    The evolution of accessory air-breathing structures is typically associated with reduction of the gills, although branchial ion transport remains pivotal for acid-base and ion regulation. Therefore, air-breathing fishes are believed to have a low capacity for extracellular pH regulation during a respiratory acidosis. In the present study, we investigated acid-base regulation during hypercapnia in the air-breathing fish Pangasianodon hypophthalmus in normoxic and hypoxic water at 28-30°C. Contrary to previous studies, we show that this air-breathing fish has a pronounced ability to regulate extracellular pH (pHe) during hypercapnia, with complete metabolic compensation of pHe within 72 h of exposure to hypoxic hypercapnia with CO2 levels above 34 mmHg. The high capacity for pHe regulation relies on a pronounced ability to increase levels of HCO3(-) in the plasma. Our study illustrates the diversity in the physiology of air-breathing fishes, such that generalizations across phylogenies may be difficult. © 2015. Published by The Company of Biologists Ltd.

  10. Economic analysis of Japanese air pollution regulation : an optimal retirement problem under the vehicle type regulation in the NOx-particulate matter law

    Science.gov (United States)

    2009-05-01

    This paper examines the vehicle type regulation that was introduced under the Automobile : Nitrogen OxidesParticulate Matter Law to mitigate air pollution in Japanese metropolitan : areas. The vehicle type regulation effectively sets the timing fo...

  11. Economic analysis of a Japanese air pollution regulation : an optimal retirement problem under vehicle type regulation in the NOx-particulate matter law

    Science.gov (United States)

    2008-06-01

    This paper empirically examines the vehicle type regulation that was introduced under the : Automobile Nitrogen OxidesParticulate Matter Law to mitigate air pollution problems in Japanese metropolitan areas. The vehicle type regulation effectively...

  12. Knife-edge seal for vacuum bagging

    Science.gov (United States)

    Rauschl, J. A.

    1980-01-01

    Cam actuated clamps pinch bagging material between long knife edge (mounted to clamps) and high temperature rubber cushion bonded to baseplate. No adhesive, tape, or sealing groove is needed to seal edge of bagging sheet against base plate.

  13. BAG3 facilitates the clearance of endogenous tau in primary neurons.

    Science.gov (United States)

    Lei, Zhinian; Brizzee, Corey; Johnson, Gail V W

    2015-01-01

    Tau is a microtubule associated protein that is found primarily in neurons, and in pathologic conditions, such as Alzheimer's disease (AD) it accumulates and contributes to the disease process. Because tau plays a fundamental role in the pathogenesis of AD and other tauopathies, and in AD mouse models reducing tau levels improves outcomes, approaches that facilitate tau clearance are being considered as therapeutic strategies. However, fundamental to the development of such interventions is a clearer understanding of the mechanisms that regulate tau clearance. Here, we report a novel mechanism of tau degradation mediated by the co-chaperone BAG3. BAG3 has been shown to be an essential component of a complex that targets substrates to the autophagy pathway for degradation. In rat primary neurons, activation of autophagy by inhibition of proteasome activity or treatment with trehalose resulted in significant decreases in tau and phospho-tau levels. These treatments also induced an upregulation of BAG3. Proteasome inhibition activated JNK, which was responsible for the upregulation of BAG3 and increased tau clearance. Inhibiting JNK or knocking down BAG3 blocked the proteasome inhibition-induced decreases in tau. Further, BAG3 overexpression alone resulted in significant decreases in tau and phospho-tau levels in neurons. These results indicate that BAG3 plays a critical role in regulating the levels of tau in neurons, and interventions that increase BAG3 levels could provide a therapeutic approach in the treatment of AD. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. 21 CFR 880.6050 - Ice bag.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ice bag. 880.6050 Section 880.6050 Food and Drugs....6050 Ice bag. (a) Identification. An ice bag is a device intended for medical purposes that is in the... the body. The device may include a holder that keeps the bag in place against an external area of the...

  15. ARE PLASTIC GROCERY BAGS SACKING THE ENVIRONMENT?

    Directory of Open Access Journals (Sweden)

    Mangal Gogte

    2009-12-01

    Full Text Available This paper is oriented on analysis impacts of plastic bags on environment. In this paper is analyzed did plastic bags are so harmful, and what are the main ingredients of it. One part of this paper is oriented on effects of plastic bags and management of their usage. There is also made comparative analysis between impacts of plastic and paper bags on environment.

  16. Air

    International Nuclear Information System (INIS)

    Gugele, B.; Scheider, J.; Spangl, W.

    2001-01-01

    In recent years several regulations and standards for air quality and limits for air pollution were issued or are in preparation by the European Union, which have severe influence on the environmental monitoring and legislation in Austria. This chapter of the environmental control report of Austria gives an overview about the legal situation of air pollution control in the European Union and in specific the legal situation in Austria. It gives a comprehensive inventory of air pollution measurements for the whole area of Austria of total suspended particulates, ozone, volatile organic compounds, nitrogen oxides, sulfur dioxide, carbon monoxide, heavy metals, benzene, dioxin, polycyclic aromatic hydrocarbons and eutrophication. For each of these pollutants the measured emission values throughout Austria are given in tables and geographical charts, the environmental impact is discussed, statistical data and time series of the emission sources are given and legal regulations and measures for an effective environmental pollution control are discussed. In particular the impact of fossil-fuel power plants on the air pollution is analyzed. (a.n.)

  17. Testing of Replacement Bag Material

    International Nuclear Information System (INIS)

    Laurinat, J.E.

    1998-01-01

    Recently, the FB-Line bagout material was changed to simplify the processing of sand, slag, and crucible.The results of the strength tests and the outgassing measurements and calculations demonstrate that the proposed replacement nylon bag materials (HRMP and orange anti-static material) are acceptable substitutes for LDPE and the original nylon with respect to mechanical properties

  18. Ergonomics and safety of manual bag sealing.

    NARCIS (Netherlands)

    Groot, M.D. de; Bosch, T.; Eikhout, S.M.; Vink, P.

    2005-01-01

    A variety of seals is used to close bags. Each seal has advantages and disadvantages. For shop assistants sealing bags could be a repetitive physically demanding action. Opening and closing the bags again can cause some discomfort or annoyance for consumers. Besides, it is an activity which can

  19. Quantization of bag-like solitons

    International Nuclear Information System (INIS)

    Breit, J.D.

    1982-01-01

    The method of collective coordinates is used to quantize bag-like solitons formed by scalar and spinor fields. This method leads to approximate wave functions for quarks in the bag that are orthogonal to the translational modes. Solutions are given for the MIT bag limit of the fields. (orig.)

  20. Massless quark wavefunction in the deformed bag

    International Nuclear Information System (INIS)

    Min, D.P.; Park, B.Y.; Koh, Y.S.

    1984-01-01

    The quark wavefunctions inside the deformed bag are obtained using a modified linear boundary condition stemming from the MIT bag Lagrangian with an additional term. We propose an exact method to obtain the quark wavefunction even for a spheroidally deformed bag. (Author)

  1. Acid-base regulation in intensively farmed air-breathing fish

    DEFF Research Database (Denmark)

    Bayley, Mark; Damsgaard, Christian; Thomsen, Mikkel

    Hypercapnia in slow moving organically loaded tropical waters is a natural occurrence with several records of pCO2 at 60 mm Hg. Despite this, studies on South American air-breathing fish have revealed a low capacity for extracellular pH (pHe) regulation. The two underlying reasons proposed are; 1......) an osmorespiratory compromise with reduced branchial surface area and reduced branchial ventilation 2) low ion concentrations in the very soft amazon waters limiting the capacity for branchial pH regulation. The Mekong delta region houses extremely intensive aquaculture of a large number of air-breathing species...

  2. The prosurvival protein BAG3: a new participant in vascular homeostasis.

    Science.gov (United States)

    Carrizzo, Albino; Damato, Antonio; Ambrosio, Mariateresa; Falco, Antonia; Rosati, Alessandra; Capunzo, Mario; Madonna, Michele; Turco, Maria C; Januzzi, James L; De Laurenzi, Vincenzo; Vecchione, Carmine

    2016-10-20

    Bcl2-associated athanogene 3 (BAG3), is constitutively expressed in a few normal cell types, including myocytes, peripheral nerves and in the brain, and is also expressed in certain tumors. To date, the main studies about the role of BAG3 are focused on its pro-survival effect in tumors through various mechanisms that vary according to cellular type. Recently, elevated concentrations of a soluble form of BAG3 were described in patients affected by advanced stage of heart failure (HF), identifying BAG3 as a potentially useful biomarker in monitoring HF progression. Despite the finding of high levels of BAG3 in the sera of HF patients, there are no data on its possible role on the modulation of vascular tone and blood pressure levels. The aim of this study was to investigate the possible hemodynamic effects of BAG3 performing both in vitro and in vivo experiments. Through vascular reactivity studies, we demonstrate that BAG3 is capable of evoking dose-dependent vasorelaxation. Of note, BAG3 exerts its vasorelaxant effect on resistance vessels, typically involved in the blood pressure regulation. Our data further show that the molecular mechanism through which BAG3 exerts this effect is the activation of the PI3K/Akt signalling pathway leading to nitric oxide release by endothelial cells. Finally, we show that in vivo BAG3 administration is capable of regulating blood pressure and that this is dependent on eNOS regulation since this ability is lost in eNOS KO animals.

  3. Stability of odorants from pig production in sampling bags for olfactometry.

    Science.gov (United States)

    Hansen, Michael J; Adamsen, Anders P S; Feilberg, Anders; Jonassen, Kristoffer E N

    2011-01-01

    Odor from pig production facilities is typically measured with olfactometry, whereby odor samples are collected in sampling bags and assessed by human panelists within 30 h. In the present study, the storage stability of odorants in two types of sampling bags that are often used for olfactometry was investigated. The bags were made of Tedlar or Nalophan. In a field experiment, humid and dried air samples were collected from a pig production facility with growing-finishing pigs and analyzed with a gas chromatograph with an amperometric sulfur detector at 4, 8, 12, 28, 52, and 76 h after sampling. In a laboratory experiment, the bags were filled with a humid gas mixture containing carboxylic acids, phenols, indoles, and sulfur compounds and analyzed with proton-transfer-reaction mass spectrometry after 0, 4, 8, 12, and 24 h. The results demonstrated that the concentrations of carboxylic acids, phenols, and indoles decreased by 50 to >99% during the 24 h of storage in Tedlar and Nalophan bags. The concentration of hydrogen sulfide decreased by approximately 30% during the 24 h of storage in Nalophan bags, whereas in Tedlar bags the concentration of sulfur compounds decreased by bags, and the composition changes toward a higher relative presence of sulfur compounds. This can result in underestimation of odor emissions from pig production facilities and of the effect of odor reduction technologies. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  4. Air Research

    Science.gov (United States)

    EPA's air research provides the critical science to develop and implement outdoor air regulations under the Clean Air Act and puts new tools and information in the hands of air quality managers and regulators to protect the air we breathe.

  5. The Anti-Apoptotic Activity of BAG3 Is Restricted by Caspases and the Proteasome

    OpenAIRE

    Virador, Victoria M.; Davidson, Ben; Czechowicz, Josephine; Mai, Alisha; Kassis, Jareer; Kohn, Elise C.

    2009-01-01

    Background Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such as AKT, from proteasomal degradation and conferred cytoprotection against heat shock. We hypothesized that the BAG3 protein is regulated by proteolysis. Methodology/Principal Findings Staurosporine (STS) was used as a tool to test ...

  6. The effects of air pollution regulations on the US refining industry

    International Nuclear Information System (INIS)

    1989-06-01

    Numerous air pollution regulations affecting petroleum refineries recently have been promulgated, have been proposed, or are under consideration at the federal, state, and local level. As shown in Figure ES-1, all of these environmental regulations are intended to take effect over the relatively short time period from 1989 through 1995. In the aggregate these regulatory activities have significant implications for the US refining industry and the Nation, including: Major investment requirements; changes in industry profitability; potential closure of some refineries; and potential changes in crude oil or product import dependence. At issue is whether the cumulative effect of these regulations could so adversely affect the US refining industry that US national security would be affected. In addition to the regulations outlined in Figure ES-1, President Bush recently presented a major new plan to improve the nation's air quality. The aspects of the President's plan that could strongly affect US refineries are summarized below

  7. UNMANNED AIR VEHICLE STABILIZATION BASED ON NEURAL NETWORK REGULATOR

    Directory of Open Access Journals (Sweden)

    S. S. Andropov

    2016-09-01

    Full Text Available A problem of stabilizing for the multirotor unmanned aerial vehicle in an environment with external disturbances is researched. A classic proportional-integral-derivative controller is analyzed, its flaws are outlined: inability to respond to changing of external conditions and the need for manual adjustment of coefficients. The paper presents an adaptive adjustment method for coefficients of the proportional-integral-derivative controller based on neural networks. A neural network structure, its input and output data are described. Neural networks with three layers are used to create an adaptive stabilization system for the multirotor unmanned aerial vehicle. Training of the networks is done with the back propagation method. Each neural network produces regulator coefficients for each angle of stabilization as its output. A method for network training is explained. Several graphs of transition process on different stages of learning, including processes with external disturbances, are presented. It is shown that the system meets stabilization requirements with sufficient number of iterations. Described adjustment method for coefficients can be used in remote control of unmanned aerial vehicles, operating in the changing environment.

  8. Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.

    Science.gov (United States)

    Cheung, Joseph Y; Gordon, Jennifer; Wang, JuFang; Song, Jianliang; Zhang, Xue-Qian; Tilley, Douglas G; Gao, Erhe; Koch, Walter J; Rabinowitz, Joseph; Klotman, Paul E; Khalili, Kamel; Feldman, Arthur M

    2015-08-01

    Since highly active antiretroviral therapy improved long-term survival of acquired immunodeficiency syndrome (AIDS) patients, AIDS cardiomyopathy has become an increasingly relevant clinical problem. We used human immunodeficiency virus (HIV)-1 transgenic (Tg26) mouse to explore molecular mechanisms of AIDS cardiomyopathy. Tg26 mice had significantly lower left ventricular (LV) mass and smaller end-diastolic and end-systolic LV volumes. Under basal conditions, cardiac contractility and relaxation and single myocyte contraction dynamics were not different between wild-type (WT) and Tg26 mice. Ten days after open heart surgery, contractility and relaxation remained significantly depressed in Tg26 hearts, suggesting that Tg26 mice did not tolerate surgical stress well. To simulate heart failure in which expression of Bcl2-associated athanogene 3 (BAG3) is reduced, we down-regulated BAG3 by small hairpin ribonucleic acid in WT and Tg26 hearts. BAG3 down-regulation significantly reduced contractility in Tg26 hearts. BAG3 overexpression rescued contractile abnormalities in myocytes expressing the HIV-1 protein Tat. We conclude: (i) Tg26 mice exhibit normal contractile function at baseline; (ii) Tg26 mice do not tolerate surgical stress well; (iii) BAG3 down-regulation exacerbated cardiac dysfunction in Tg26 mice; (iv) BAG3 overexpression rescued contractile abnormalities in myocytes expressing HIV-1 protein Tat; and (v) BAG3 may occupy a role in pathogenesis of AIDS cardiomyopathy. © 2015 Wiley Periodicals, Inc.

  9. A deformable bag model of hadrons, 1

    International Nuclear Information System (INIS)

    Ui, Haruo; Saito, Koich

    1983-01-01

    As a generalization of the MIT spherical bag model, we construct the spheroidal bag model of hadron with an arbitrary eccentricity. This generalization is made by slightly modifying the MIT linear boundary condition: The linear boundary condition is examined in detail. Our model always satisfies two necessary requirements of the MIT bag model - i.e., n.j = 0, no quark colour flux leaves the bag, and q-barq = 0, the scalar density of quark should vanish on the bag surface- and it reduces to the MIT spherical bag model in the limit of zero-eccentricity. Lagrangian formalism of our model is briefly described. The eigenfrequencies of a single massless quark confined in this spheroidal bag are numerically calculated. We obtain the level-splitting of the excited quark orbits, which is just analogous to the well-known Nilsson's splitting of single particle orbits in deformed nuclei. By using the numerical results of the lowest orbit, the effect of the bag-deformation on the mass of low-lying hadrons is estimated. It is found that, although the spherical bag is stable, the quark bag is extremely soft against the quadrupole deformation. Brief discussions are added on the mechanisms which make the spherical bag more stable. (author)

  10. Technology & Mechanics Overview of Air-Inflated Fabric Structures

    National Research Council Canada - National Science Library

    Cavallaro, Paul V

    2006-01-01

    .... Examples include air ships, weather balloons, inflatable radomes, shelters, pneumatic muscles, inflatable boats, bridging, and energy absorbers such as automotive air bags and landing cushions for space vehicles...

  11. Bag-breakup control of surface drag in hurricanes

    Science.gov (United States)

    Troitskaya, Yuliya; Zilitinkevich, Sergej; Kandaurov, Alexander; Ermakova, Olga; Kozlov, Dmitry; Sergeev, Daniil

    2016-04-01

    Air-sea interaction at extreme winds is of special interest now in connection with the problem of the sea surface drag reduction at the wind speed exceeding 30-35 m/s. This phenomenon predicted by Emanuel (1995) and confirmed by a number of field (e.g., Powell, et al, 2003) and laboratory (Donelan et al, 2004) experiments still waits its physical explanation. Several papers attributed the drag reduction to spume droplets - spray turning off the crests of breaking waves (e.g., Kudryavtsev, Makin, 2011, Bao, et al, 2011). The fluxes associated with the spray are determined by the rate of droplet production at the surface quantified by the sea spray generation function (SSGF), defined as the number of spray particles of radius r produced from the unit area of water surface in unit time. However, the mechanism of spume droplets' formation is unknown and empirical estimates of SSGF varied over six orders of magnitude; therefore, the production rate of large sea spray droplets is not adequately described and there are significant uncertainties in estimations of exchange processes in hurricanes. Herewith, it is unknown what is air-sea interface and how water is fragmented to spray at hurricane wind. Using high-speed video, we observed mechanisms of production of spume droplets at strong winds by high-speed video filming, investigated statistics and compared their efficiency. Experiments showed, that the generation of the spume droplets near the wave crest is caused by the following events: bursting of submerged bubbles, generation and breakup of "projections" and "bag breakup". Statistical analysis of results of these experiments showed that the main mechanism of spray-generation is attributed to "bag-breakup mechanism", namely, inflating and consequent blowing of short-lived, sail-like pieces of the water-surface film. Using high-speed video, we show that at hurricane winds the main mechanism of spray production is attributed to "bag-breakup", namely, inflating and

  12. Vector-Interaction-Enhanced Bag Model

    Science.gov (United States)

    Cierniak, Mateusz; Klähn, Thomas; Fischer, Tobias; Bastian, Niels-Uwe

    2018-02-01

    A commonly applied quark matter model in astrophysics is the thermodynamic bag model (tdBAG). The original MIT bag model approximates the effect of quark confinement, but does not explicitly account for the breaking of chiral symmetry, an important property of Quantum Chromodynamics (QCD). It further ignores vector repulsion. The vector-interaction-enhanced bag model (vBag) improves the tdBAG approach by accounting for both dynamical chiral symmetry breaking and repulsive vector interactions. The latter is of particular importance to studies of dense matter in beta-equilibriumto explain the two solar mass maximum mass constraint for neutron stars. The model is motivated by analyses of QCD based Dyson-Schwinger equations (DSE), assuming a simple quark-quark contact interaction. Here, we focus on the study of hybrid neutron star properties resulting from the application of vBag and will discuss possible extensions.

  13. Transport of radioactive material by air, proposal for a revision of the regulation

    International Nuclear Information System (INIS)

    Devillers, C.; Ringot, C.

    1989-01-01

    The regulation should be modified in such a way that the packages used for the air transport of radioactive material presenting a high level of potential danger be designed to fulfill their safety functions for a large fraction of the conditions likely to be encountered in an aircraft accident

  14. Air quality in natural areas: Interface between the public, science and regulation

    International Nuclear Information System (INIS)

    Percy, K.E.; Karnosky, D.F.

    2007-01-01

    Natural areas are important interfaces between air quality, the public, science and regulation. In the United States and Canada, national parks received over 315 million visits during 2004. Many natural areas have been experiencing decreased visibility, increased ozone (O 3 ) levels and elevated nitrogen deposition. Ozone is the most pervasive air pollutant in North American natural areas. There is an extensive scientific literature on O 3 exposure-tree response in chambered environments and, lately, free-air exposure systems. Yet, less is known about O 3 impacts on natural terrestrial ecosystems. To advance scientifically defensible O 3 risk assessment for natural forest areas, species-level measurement endpoints must be socially, economically and ecologically relevant. Exposure-based indices, based on appropriate final endpoints, present an underused opportunity to meet this need. Exposure-plant indices should have a high degree of statistical significance, have high goodness of fit, be biologically plausible and include confidence intervals to define uncertainty. They must be supported by exposure-response functions and be easy to use within an air quality regulation context. Ozone exposure-response indices developed within an ambient air context have great potential for improving risk assessment in natural forest areas and enhancing scientific literacy. - Appropriate endpoints and exposure-response indices can improve assessment of air pollutant risk to forests in natural areas

  15. Air quality in natural areas: Interface between the public, science and regulation

    Energy Technology Data Exchange (ETDEWEB)

    Percy, K.E. [Natural Resources Canada, Canadian Forest Service - Atlantic Forestry Centre, 1350 Regent Street, Fredericton, New Brunswick E3B 5P7 (Canada)], E-mail: kpercy@nrcan.gc.ca; Karnosky, D.F. [School of Forest Resources and Environmental Science, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931 (United States)

    2007-10-15

    Natural areas are important interfaces between air quality, the public, science and regulation. In the United States and Canada, national parks received over 315 million visits during 2004. Many natural areas have been experiencing decreased visibility, increased ozone (O{sub 3}) levels and elevated nitrogen deposition. Ozone is the most pervasive air pollutant in North American natural areas. There is an extensive scientific literature on O{sub 3} exposure-tree response in chambered environments and, lately, free-air exposure systems. Yet, less is known about O{sub 3} impacts on natural terrestrial ecosystems. To advance scientifically defensible O{sub 3} risk assessment for natural forest areas, species-level measurement endpoints must be socially, economically and ecologically relevant. Exposure-based indices, based on appropriate final endpoints, present an underused opportunity to meet this need. Exposure-plant indices should have a high degree of statistical significance, have high goodness of fit, be biologically plausible and include confidence intervals to define uncertainty. They must be supported by exposure-response functions and be easy to use within an air quality regulation context. Ozone exposure-response indices developed within an ambient air context have great potential for improving risk assessment in natural forest areas and enhancing scientific literacy. - Appropriate endpoints and exposure-response indices can improve assessment of air pollutant risk to forests in natural areas.

  16. Potential impact of a US climate policy and air quality regulations on future air quality and climate change

    Science.gov (United States)

    Lee, Yunha; Shindell, Drew T.; Faluvegi, Greg; Pinder, Rob W.

    2016-04-01

    We have investigated how future air quality and climate change are influenced by the US air quality regulations that existed or were proposed in 2013 and a hypothetical climate mitigation policy that aims to reduce 2050 CO2 emissions to be 50 % below 2005 emissions. Using the NASA GISS ModelE2 general circulation model, we look at the impacts for year 2030 and 2055. The US energy-sector emissions are from the GLIMPSE project (GEOS-Chem LIDORT Integrated with MARKAL (MARKet ALlocation) for the Purpose of Scenario Exploration), and other US emissions data sets and the rest of the world emissions data sets are based on the RCP4.5 scenario. The US air quality regulations are projected to have a strong beneficial impact on US air quality and public health in year 2030 and 2055 but result in positive radiative forcing. Under this scenario, no more emission constraints are added after 2020, and the impacts on air quality and climate change are similar between year 2030 and 2055. Surface particulate matter with a diameter smaller than 2.5 µm (PM2.5) is reduced by ˜ 2 µg m-3 on average over the USA, and surface ozone by ˜ 8 ppbv. The improved air quality prevents about 91 400 premature deaths in the USA, mainly due to the PM2.5 reduction (˜ 74 200 lives saved). The air quality regulations reduce the light-reflecting aerosols (i.e., sulfate and organic matter) more than the light-absorbing species (i.e., black carbon and ozone), leading to a strong positive radiative forcing (RF) over the USA by both aerosols' direct and indirect forcing: the total RF is ˜ 0.04 W m-2 over the globe, and ˜ 0.8 W m-2 over the USA. Under the hypothetical climate policy, a future CO2 emissions cut is achieved in part by relying less on coal, and thus SO2 emissions are noticeably reduced. This provides air quality co-benefits, but it could lead to potential climate disbenefits over the USA. In 2055, the US mean total RF is +0.22 W m-2 due to positive aerosol direct and indirect forcing

  17. Potential impact of a US climate policy and air quality regulations on future air quality and climate change

    Directory of Open Access Journals (Sweden)

    Y. Lee

    2016-04-01

    Full Text Available We have investigated how future air quality and climate change are influenced by the US air quality regulations that existed or were proposed in 2013 and a hypothetical climate mitigation policy that aims to reduce 2050 CO2 emissions to be 50 % below 2005 emissions. Using the NASA GISS ModelE2 general circulation model, we look at the impacts for year 2030 and 2055. The US energy-sector emissions are from the GLIMPSE project (GEOS-Chem LIDORT Integrated with MARKAL (MARKet ALlocation for the Purpose of Scenario Exploration, and other US emissions data sets and the rest of the world emissions data sets are based on the RCP4.5 scenario. The US air quality regulations are projected to have a strong beneficial impact on US air quality and public health in year 2030 and 2055 but result in positive radiative forcing. Under this scenario, no more emission constraints are added after 2020, and the impacts on air quality and climate change are similar between year 2030 and 2055. Surface particulate matter with a diameter smaller than 2.5 µm (PM2.5 is reduced by ∼ 2 µg m−3 on average over the USA, and surface ozone by ∼ 8 ppbv. The improved air quality prevents about 91 400 premature deaths in the USA, mainly due to the PM2.5 reduction (∼ 74 200 lives saved. The air quality regulations reduce the light-reflecting aerosols (i.e., sulfate and organic matter more than the light-absorbing species (i.e., black carbon and ozone, leading to a strong positive radiative forcing (RF over the USA by both aerosols' direct and indirect forcing: the total RF is  ∼ 0.04 W m−2 over the globe, and ∼ 0.8 W m−2 over the USA. Under the hypothetical climate policy, a future CO2 emissions cut is achieved in part by relying less on coal, and thus SO2 emissions are noticeably reduced. This provides air quality co-benefits, but it could lead to potential climate disbenefits over the USA. In 2055, the US mean total RF is +0.22

  18. Potential Impact of a US Climate Policy and Air Quality Regulations on Future Air Quality and Climate Change

    Science.gov (United States)

    Lee, Y. H.; Faluvegi, Gregory S.

    2016-01-01

    We have investigated how future air quality and climate change are influenced by the US air quality regulations that existed or were proposed in 2013 and a hypothetical climate mitigation policy that aims to reduce 2050 CO2 emissions to be 50% below 2005 emissions. Using the NASA GISS ModelE2 general circulation model, we look at the impacts for year 2030 and 2055. The US energy-sector emissions are from the GLIMPSE project (GEOS-Chem LIDORT Integrated with MARKAL (MARKet ALlocation) for the Purpose of Scenario Exploration), and other US emissions data sets and the rest of the world emissions data sets are based on the RCP4.5 scenario. The US air quality regulations are projected to have a strong beneficial impact on US air quality and public health in year 2030 and 2055 but result in positive radiative forcing. Under this scenario, no more emission constraints are added after 2020, and the impacts on air quality and climate change are similar between year 2030 and 2055. Surface particulate matter with a diameter smaller than 2.5 micron PM(sub 2:5) is reduced by 2 approximately µg/m(sup -3) on average over the USA, and surface ozone by approximately 8 ppbv. The improved air quality prevents about 91 400 premature deaths in the USA, mainly due to the PM(sub 2:5) reduction approximately (74 200 lives saved). The air quality regulations reduce the light-reflecting aerosols (i.e., sulfate and organic matter) more than the light-absorbing species (i.e., black carbon and ozone), leading to a strong positive radiative forcing (RF) over the USA by both aerosols' direct and indirect forcing: the total RF is approximately 0.04 W m(sup -2) over the globe, and approximately 0.8 W m(sup -2) over the USA. Under the hypothetical climate policy, a future CO2 emissions cut is achieved in part by relying less on coal, and thus SO2 emissions are noticeably reduced. This provides air quality co-benefits, but it could lead to potential climate disbenefits over the USA. In 2055, the US

  19. Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney.

    Science.gov (United States)

    Du, Feng; Li, Si; Wang, Tian; Zhang, Hai-Yan; Zong, Zhi-Hong; Du, Zhen-Xian; Li, De-Tian; Wang, Hua-Qin; Liu, Bo; Miao, Jia-Ning; Bian, Xiao-Hui

    2015-01-01

    BAG3 regulates a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, and epithelial-mesenchymal transition (EMT). However, the role of BAG3 in renal tubular EMT and renal interstitial fibrosis remains elusive. This study aimed to examine the dynamic expression of BAG3 during renal fibrosis, and to investigate the efficacy of Cordyceps sinensis (C. sinensis) on renal fibrosis. A rat model of unilateral ureteral obstruction (UUO) was established, and the expression of BAG3 and α-SMA, and the efficacy of C. sinensis on renal fibrosis induced by UUO were examined. The results showed that UUO led to collagen accumulation, which was significantly suppressed by C. sinensis. UUO increased the expression of BAG3 and α-SMA, a mesenchymal marker, while UUO induced BAG3 and α-SMA expression was significantly inhibited by C. sinensis. In addition, immunohistochemical staining demonstrated that BAG3 immunoreactivity was restricted to tubular epithelium. In conclusion, BAG3 is a potential target for the prevention and/or treatment of renal fibrosis, and C. Sinensis is a promising agent for renal fibrosis.

  20. Self-consistent quark bags

    International Nuclear Information System (INIS)

    Rafelski, J.

    1979-01-01

    After an introductory overview of the bag model the author uses the self-consistent solution of the coupled Dirac-meson fields to represent a bound state of strongly ineteracting fermions. In this framework he discusses the vivial approach to classical field equations. After a short description of the used numerical methods the properties of bound states of scalar self-consistent Fields and the solutions of a self-coupled Dirac field are considered. (HSI) [de

  1. Urban air pollution produces up-regulation of myocardial inflammatory genes and dark chocolate provides cardioprotection.

    Science.gov (United States)

    Villarreal-Calderon, Rodolfo; Reed, William; Palacios-Moreno, Juan; Keefe, Sheyla; Herritt, Lou; Brooks, Diane; Torres-Jardón, Ricardo; Calderón-Garcidueñas, Lilian

    2012-05-01

    Air pollution is a serious environmental problem. Elderly subjects show increased cardiac morbidity and mortality associated with air pollution exposure. Mexico City (MC) residents are chronically exposed to high concentrations of fine particulate matter (PM(2.5)) and PM-associated lipopolysaccharides (PM-LPS). To test the hypothesis that chronic exposure to urban pollution produces myocardial inflammation, female Balb-c mice age 4 weeks were exposed for 16 months to two distinctly different polluted areas within MC: southwest (SW) and northwest (NW). SW mice were given either no treatment or chocolate 2g/9.5 mg polyphenols/3 times per week. Results were compared to mice kept in clean air. Key inflammatory mediator genes: cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and the LPS receptor CD14 (cluster of differentiation antigen 14) were measured by real-time polymerase chain reaction. Also explored were target NFκB (nuclear factor κB), oxidative stress and antioxidant defense genes. TNF-α, IL-6, and COX-2 were significantly increased in both NW and SWMC mice (p=0.0001). CD14 was up-regulated in SW mice in keeping with the high exposures to particulate matter associated endotoxin. Chocolate administration resulted in a significant down-regulation of TNF-α (p<0.0001), IL-6 (p=0.01), and IL-1β (p=0.02). The up-regulation of antioxidant enzymes and the down-regulation of potent oxidases, toll-like receptors, and pro-apoptotic signaling genes completed the protective profile. Exposure to air pollution produces up-regulation of inflammatory myocardial genes and endotoxin plays a key role in the inflammatory response. Regular consumption of dark chocolate may reduce myocardial inflammation and have cardioprotective properties in the setting of air pollution exposures. Copyright © 2010 Elsevier GmbH. All rights reserved.

  2. Models of Aire-dependent gene regulation for thymic negative selection

    Directory of Open Access Journals (Sweden)

    Dina eDanso-Abeam

    2011-05-01

    Full Text Available Mutations in the Autoimmune Regulator (AIRE gene lead to Autoimmune Polyendocrinopathy Syndrome type 1 (APS1, characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular level, the working model explains most of the clinical and immunological characteristics of APS1, with AIRE driving the expression of tissue restricted antigens (TRAs in the epithelial cells of the thymic medulla. This TRA expression results in effective negative selection of TRA-reactive thymocytes, preventing autoimmune disease. At the molecular level, the mechanism by which AIRE initiates TRA expression in the thymic medulla remains unclear. Multiple different models for the molecular mechanism have been proposed, ranging from classical transcriptional activity, to random induction of gene expression, to epigenetic tag recognition effect, to altered cell biology. In this review, we evaluate each of these models and discuss their relative strengths and weaknesses.

  3. BAG3-mediated Mcl-1 stabilization contributes to drug resistance via interaction with USP9X in ovarian cancer.

    Science.gov (United States)

    Habata, Shutaro; Iwasaki, Masahiro; Sugio, Asuka; Suzuki, Miwa; Tamate, Masato; Satohisa, Seiro; Tanaka, Ryoichi; Saito, Tsuyoshi

    2016-07-01

    Paclitaxel in combination with carboplatin improves survival among patients with susceptible ovarian cancers, but no strategy has been established against resistant ovarian cancers. BAG3 (Bcl-2-associated athanogene 3) is one of six BAG family proteins, which are involved in such cellular processes as proliferation, migration and apoptosis. In addition, expression of BAG3 with Mcl-1, a Bcl-2 family protein, reportedly associates with resistance to chemotherapy. Our aim in this study was to evaluate the functional role of BAG3 and Mcl-1 in ovarian cancer chemoresistance and explore possible new targets for treatment. We found that combined expression of BAG3 and Mcl-1 was significantly associated with a poor prognosis in ovarian cancer patients. In vitro, BAG3 knockdown in ES2 clear ovarian cancer cells significantly increased the efficacy of paclitaxel in combination with the Mcl-1 antagonist MIM1, with or without the Bcl-2 family antagonist ABT737. Moreover, BAG3 was found to positively regulate Mcl-1 levels by binding to and inhibiting USP9X. Our data show that BAG3 and Mcl-1 are key mediators of resistance to chemotherapy in ovarian cancer. In BAG3 knockdown ES2 clear ovarian cancer cells, combination with ABT737 and MIM1 enhanced the efficacy of paclitaxel. These results suggest that inhibiting BAG3 in addition to anti-apoptotic Bcl-2 family proteins may be a useful therapeutic strategy for the treatment of chemoresistant ovarian cancers.

  4. Analysis of a classical chiral bag model

    International Nuclear Information System (INIS)

    Nadeau, H.

    1985-01-01

    The author studies a classical chiral bag model with a Mexican hat-type potential for the self-coupling of the pion fields. He assumes a static spherical bag of radius R, the hedgehog ansatz for the chiral fields and that the quarks are all in the lowest lying s state. The author has considered three classes of models, the cloudy or pantopionic bags, the little or exopionic bags and the endopionic bags, where the pions are allowed all through space, only outside the bag and only inside the bag respectively. In all cases, the quarks are confined in the interior. He calculates the bag radius R, the bag constant B and the total ground state energy R for wide ranges of the two free parameters of the theory, namely the coupling constant λ and the quark frequency omega. The author focuses the study on the endopionic bags, the least known class, and compares the results with the familiar ones of other classes

  5. Chiral pion dynamics for spherical nucleon bags

    International Nuclear Information System (INIS)

    Vento, V.; Rho, M.; Nyman, E.M.; Jun, J.H.; Brown, G.E.; CEA Centre d'Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette

    1980-01-01

    A chirally symmetric quark-bag model for the nucleon is obtained by introducing an explicit, classical, pion field exterior to the bag. The coupling at the bag surface is determined by the requirement of a conserved axial-vector current. The pion field satisfies equations of motion corresponding to the non-linear sigma-model. We study on this paper the simplified case where the bag and the pion field are spherically symmetric. Corrections due to gluon exchange between the quarks are ignored along with other interactions which split the N- and Δ-masses. The equations of motion for the pion field are solved and we find a substantial pion pressure at the bag surface, along with an attractive contribution to the nucleon self-energy. The total energy of the system, bag plus meson cloud, turns out to be approximately Msub(n)c 2 for a wide range of bag radii, from 1.5 fm down to about 0.5 fm. Introduction of a form factor for the pion would extend the range of possible radii to even smaller values. We propose that the bag with the smallest allowed radius be identified with the 'little bag' discussed before. One surprising result of the paper is that as long as one restricts to spherically symmetric bags, restoring chiral symmetry to the bag model makes the axial-vector current coupling constant gsub(A) to be always too large compared with the experimental value for any bag radius, suggesting a deviation from spherical symmetry for the intrinsic bag wave functions of the 'ground-state' hadrons. (orig.)

  6. Projections of air toxic emissions from coal-fired utility combustion: Input for hazardous air pollutant regulators

    International Nuclear Information System (INIS)

    Szpunar, C.B.

    1993-01-01

    The US Environmental Protection Agency (EPA) is required by the 1990 CAAA to promulgate rules for all ''major'' sources of any of these HAPs. According to the HAPs section of the new Title III, any stationary source emitting 10 tons per year (TPY) of one HAP or 25 TPY of a combination of HAPs will be considered and designated a major source. In contrast to the original National Emission Standards for Hazardous Air Pollutants (NESHAP), which were designed to protect public health to ''an ample margin of safety,'' the new Title III, in its first phase, will regulate by industrial category those sources emitting HAPs in excess of the 10/25-TPY threshold levels, regardless of health risks. The trace elements normally associated with coal mineral matter and the various compounds formed during coal combustion have the potential to produce hazardous air toxic emissions from coal-fired electric utilities. Under Title III, the EPA is required to perform certain studies, prior to any regulation of electric utilities; these studies are currently underway. Also, the US Department of Energy (DOE) maintains a vested interest in addressing those energy policy questions affecting electric utility generation, coal mining, and steel producing critical to this country's economic well-being, where balancing the costs to the producers and users of energy with the benefits of environmental protection to the workers and the general populace remains of significant concern

  7. Modelling air quality according to INSPIRE data specifications, ISO standards and national regulations

    Directory of Open Access Journals (Sweden)

    Pachelski Wojciech

    2017-12-01

    Full Text Available Protection of the environment is an activity of many institutions, organizations and communities from global to regional and local scales. Any activity in this area needs structured database records, using advanced methodology, given, among others, in INSPIRE documents, ISO standards of 19100 series, and national regulations. The goal of this paper is to analyse both the legal provisions related to the air quality and also data sources associated with the prevention of air pollution. Furthermore, the UML application schema of the spatial data related to the air protection is proposed, for the use by urban planners. Also, the overview of the methodology of geographic information is given, including the Unified Modelling Language (UML, as well as the basic concepts of conceptual models within the INSPIRE project. The study is based on the relevant literature and documents, as well as on the expert knowledge gained through urban planning practice, as well as on the analysis of the spatial planning regulations. The UML application schema for different aspects related to the air protection, as presented in this paper, is an example of how to use the methodology also in other fields of the environment protection. Spatial planners know how to improve the air quality, but in the present state of law they often suffer from the lack of planning tools for real actions. In the spatial planners work an important issue are data that allow a thorough analysis of the area.

  8. Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer.

    Science.gov (United States)

    Zhang, Yong; Wang, Jian-Hua; Lu, Qiang; Wang, Yun-Jie

    2012-01-01

    In non-small cell lung cancer (NSCLC) certain molecular characteristics, which are related to molecular alterations have been investigated. These are responsible for both the initiation and maintenance of the malignancy in lung cancer. The aim of this study was to evaluate the influence of Bag3 (Bcl-2 associated athanogene 3) in the regulation of apoptosis on NSCLC. Bag3 and Hsp70 expression were examined by immunohistochemistry to confirm their potential roles in the prevalence of NSCLC. We also established human normal bronchial epithelial cells and HOP-62 cell line as the model to analyze cell apoptosis and the expression of Hsp70, Bcl-XL and Bcl-2, which were affected by Bag3. In this study, we found that Bag3 and Hsp70 are highly expressed in few tissues and cell lines of NSCLC. Bag3 inhibits apoptosis in human normal bronchial epithelial cell lines and sustain the survival of NSCLC cells. Bag3, Hsp70, Bcl-XL and Bcl-2 are up-regulated in NSCLC cell lines. At the same time, the silencing of Bag3 results in diminishing protein levels of Bcl-XL and Bcl-2. The results of immunoprecipitation identified that Bag3 could interact with Hsp70, Bcl-XL and Bcl-2 NSCLC cells directly or indirectly. We conclude that NSCLC cells were protected from apoptosis through increasing Bag3 expression and consequently promoted the expression of Bcl-XL and Bcl-2.

  9. Pressure Regulators as Valves for Saving Compressed Air and their Influence on System Dynamics

    Directory of Open Access Journals (Sweden)

    Dvořák Lukáš

    2015-01-01

    Full Text Available Pressure regulators in the field of pneumatic mechanisms can be used as valves for saving compressed air. For example it can be used to reduce the pressure when the piston rod is retracting unloaded and thus it is possible to save some energy. However the problem is that saving valve can significantly affect the dynamics of the pneumatic system. The lower pressure in the piston rod chamber causes extension of time for retraction of the piston rod. This article compare the air consumption experimentally determined and calculated, measured curves of pressure in cylinder chambers and piston speed when saving valve is set up differently.

  10. Pressure Regulators as Valves for Saving Compressed Air and their Influence on System Dynamics

    Science.gov (United States)

    Dvořák, Lukáš; Fojtášek, Kamil

    2015-05-01

    Pressure regulators in the field of pneumatic mechanisms can be used as valves for saving compressed air. For example it can be used to reduce the pressure when the piston rod is retracting unloaded and thus it is possible to save some energy. However the problem is that saving valve can significantly affect the dynamics of the pneumatic system. The lower pressure in the piston rod chamber causes extension of time for retraction of the piston rod. This article compare the air consumption experimentally determined and calculated, measured curves of pressure in cylinder chambers and piston speed when saving valve is set up differently.

  11. Review of current and anticipated regulations on air protection in the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    Jilek, P.; Novotny, V. [Ministry of the Environment of the Czech Republic, Prague (Czechoslovakia)

    1995-12-01

    Environmental issues, especially the solution of the air pollution problem, have taken on great significance in the Czech Republic (which was a part of the Czech and Slovak Federal Republic until the end of 1992) since the 1989 {open_quotes}Velvet{close_quotes} Revolution. The former CSFR Federal Committee for the Environment and both the Republic Ministries started immediately with creating new environmental legislation, which is the main governmental tool for protecting the environment in the newly developing democracy state system with a market oriented economy. The inspiration for that activity was found in legislation of developed countries - member states of the European Union, and in German environmental law in particular. This paper surveys the major laws and regulations that gradually came into force in the Czech Republic since 1990. The provisions of the primary significance are the Act No.309/1991 S.B., dated July 9, 1991, on the protection of the air against pollutants - The Clean Air Act, the Act No.218/1992 S.B., dated April 27, 1992, which changes and supplements the Act No.309 - The Clean Air Act, the Measure of the Federal Committee for the Environment of October 1, 1991 to the Clean Air Act, and its amended wordings of June 23, 1992, 84/1991 S.B., and 84/1992 S.B., the Act No.389/1991 S.B., dated September 10, 1991 on the state administration of air protection and charges for the pollution of air, and several regulations based on the Act No.389/1991 S.B., issued in the period 1992 -1993.

  12. Hazardous emissions, operating practices, and air regulations at industrial wood-fired facilities in Wisconsin

    International Nuclear Information System (INIS)

    Hubbard, A.J.

    1993-01-01

    Since October of 1988 the State of Wisconsin Department of Natural Resources has regulated over four hundred substances as hazardous air pollutants. The rule regulates new as well as existing sources of air pollution in Wisconsin. Consequently, all permits to operate an air pollution source in Wisconsin must address the hazardous air emissions potential of the source. While widely perceived as a clean-burning fuel, wood is often burned in a manner which clearly results in significant emissions of very hazardous air pollutants. Research conducted on a 20 million BTU per hour wood-fired spreader stoker boiler in northern Wisconsin showed that this boiler has the potential to emit 0.022 pound of benzene and 0.012 pound of formaldehyde per ton (lb/ton) of wood fired. Recent stack tests at more than a dozen other small industrial wood-fired facilities in Wisconsin show a range of formaldehyde emissions of 0.0007--0.1950 lb/ton. Work at Birchwood Lumber ampersand Veneer showed that the benzene and formaldehyde emission rates under good firing conditions are an order of magnitude lower than the benzene and formaldehyde emission rates under poor firing conditions. This finding has supported Wisconsin's regulatory approach of encouraging wood-fired facilities to enhance the quality of the combustion process as a technique to minimize the hazardous air pollution potential of industrial wood combustion. The Wisconsin strategy is to define open-quotes good combustion technologyclose quotes through easily measurable combustion parameters rather than emission standards. This paper presents several techniques in use in Wisconsin to comply with open-quotes good combustion technologyclose quotes for industrial wood-fired furnaces. These techniques include fuel blending overfire air, furnace insulation, and proper grate design

  13. A rotating bag model for hadrons. 2

    International Nuclear Information System (INIS)

    Iwasaki, Masaharu

    1994-01-01

    The MIT bag model is modified in order to describe rotational motion of hadrons. It has a kind of 'diatomic molecular' structure; The rotational excitation of the MIT bag is described by the polarized two colored sub-bags which are connected with each other by the gluon flux. One sub-bag contains a quark and the other has an antiquark for mesons. For baryons, the latter sub-bag contains the remaining two quarks instead of the antiquark. The Regge trajectories of hadrons are explained qualitatively by our new model with the usual MIT bag parameters. In particular the Regge slopes are reproduced fairly well. It is also pointed out that the gluon flux plays an important role in the rotational motion of hadrons. (author)

  14. Effects of quantum entropy on bag constant

    International Nuclear Information System (INIS)

    Miller, D.E.; Tawfik, A.

    2012-01-01

    The effects of quantum entropy on the bag constant are studied at low temperatures and for small chemical potentials. The inclusion of the quantum entropy of the quarks in the equation of state provides the hadronic bag with an additional heat which causes a decrease in the effective latent heat inside the bag. We have considered two types of baryonic bags, Δ and Ω - . In both cases we have found that the bag constant without the quantum entropy almost does not change with temperature and quark chemical potential. The contribution from the quantum entropy to the equation of state clearly decreases the value of the bag constant. Furthermore, we construct states densities for quarks using the 'Thomas Fermi model' and take into consideration a thermal potential for the interaction. (author)

  15. Ellipsoidal bag model for heavy quark system

    International Nuclear Information System (INIS)

    Bi Pinzhen; Fudan Univ., Shanghai

    1991-01-01

    The ellipsoidal bag model is used to describe heavy quark systems such as Qanti Q, Qanti Qg and Q 2 anti Q 2 . Instead of two step model, these states are described by an uniform picture. The potential derived from the ellipsoidal bag for Qanti Q is almost equivalent to the Cornell potential. For a Q 2 anti Q 2 system with large quark pair separation, an improvement of 70 MeV is obtained comparing with the spherical bag. (orig.)

  16. Bag model with broken chiral symmetry

    International Nuclear Information System (INIS)

    Efrosinin, V.P.; Zaikin, D.A.

    1986-01-01

    A variant of the bag model in which chiral symmetry is broken and which provides a description of all the experimental data on the light hadrons, including the pion, is discussed. The pion and kaon decay constants are calculated in this model. The problem of taking into account the center-of-mass motion in bag models and the boundary conditions in the bag model with broken chiral symmetry are also discussed

  17. Comparison of storage stability of odorous VOCs in polyester aluminum and polyvinyl fluoride Tedlar® bags.

    Science.gov (United States)

    Kim, Yong-Hyun; Kim, Ki-Hyun; Jo, Sang-Hee; Jeon, Eui-Chan; Sohn, Jong Ryeul; Parker, David B

    2012-01-27

    Whole air sampling using containers such as flexible bags or rigid canisters is commonly used to collect samples of volatile organic compounds (VOC) in air. The objective of this study was to compare the stability of polyester aluminum (PEA) and polyvinyl fluoride (PVF, brand name Tedlar(®)) bags for gaseous VOC sampling. Eight VOC standards (benzene, toluene, p-xylene, styrene, methyl ethyl ketone, methyl isobutyl ketone, butyl acetate, and isobutyl alcohol) were placed into each bag at storage times of 0, 2, and 3 days prior to analyses by gas chromatography/mass spectrometry (GC/MS). From each bag representing each storage day, samples of 3 different mass loadings were withdrawn and analyzed to derive response factors (RF) of each chemical between the slope of the GC response (y-axis) vs. loaded mass (x-axis). The relative recoveries (RR) of VOC, if derived by dividing RF value of a given storage day by that of 0 day, varied by time, bag type, and VOC type. If the RR values after three days are compared, those of methyl isobutyl ketone were the highest with 96 (PVF) and 99% (PEA); however, the results of isobutyl alcohol were highly contrasting between the two bags with 31 and 94%, respectively. Differences in RR values between the two bag types increased with storage time, such that RR of PEA bags (88±10%) were superior to those of PVF bags (73±22%) after three days, demonstrating that VOC in PEA bags were more stable than in PVF bags. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Recent status of the chiral bag model

    International Nuclear Information System (INIS)

    Hosaka, Atsushi; Toki, Hiroshi.

    1995-01-01

    In this note, recent status of the chiral bag model is presented. As it combines the MIT quark bag model and the Skyrme model, the chiral bag model interpolates the two models smoothly as a function of the chiral bag radius R. The correct limit of R → ∞ is reproduced by including the higher order terms in the Ω expansion of the cranking method. It resolves the so-called small g A problem in a class of models where the semiclassical method is used. (author)

  19. 19 CFR 148.83 - Diplomatic and consular bags.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Diplomatic and consular bags. 148.83 Section 148... bags. (a) Diplomatic bags. The contents of diplomatic bags are restricted to diplomatic documents and articles intended exclusively for official use and packages constituting the diplomatic bag must bear...

  20. State regulation and teaching staff formation during the last military dictatorship in Buenos Aires Province

    Directory of Open Access Journals (Sweden)

    Myriam Southwell

    2009-06-01

    Full Text Available The last Argentine military dictatorship (1976-1983 has left deep marks in different spheres of the social, and education has not been the exception. A group of educational policies were carried out in the province of Buenos Aires that strongly transformed the senses of teaching. One of those policies has been the teacher education reform and the new course of studies for the Higher Teaching in 1977. From the advances of an ongoing research and the work on historical sources –programs, plans, regulations, government decrees, acts- we will analyse this teacher education policy as part of the teachers' work regulation and as a process of practice production.

  1. New Source Review and coal plant efficiency gains: How new and forthcoming air regulations affect outcomes

    International Nuclear Information System (INIS)

    Adair, Sarah K.; Hoppock, David C.; Monast, Jonas J.

    2014-01-01

    Forthcoming carbon dioxide (CO 2 ) regulations for existing power plants in the United States have heightened interest in thermal efficiency gains for coal-fired power plants. Plant modifications to improve thermal efficiency can trigger New Source Review (NSR), a Clean Air Act requirement to adopt of state-of-the-art pollution controls. This article explores whether existing coal plants would likely face additional pollution control requirements if they undertake modifications that trigger NSR. Despite emissions controls that are or will be installed under the Mercury and Air Toxics Standards (MATS) and Clean Air Interstate Rule (CAIR) or its replacement, 80% of coal units (76% of capacity) that are expected to remain in operation are not projected to meet the minimum NSR requirements for at least one pollutant: nitrogen oxides or sulfur dioxide. This is an important consideration for the U.S. Environmental Protection Agency and state policymakers as they determine the extent to which CO 2 regulation will rely on unit-by-unit thermal efficiency gains versus potential flexible compliance strategies such as averaging, trading, energy efficiency, and renewable energy. NSR would likely delay and add cost to thermal efficiency projects at a majority of coal units, including projects undertaken to comply with forthcoming CO 2 regulation. - Highlights: • We explore the status of the U.S. coal-fired fleet relative to New Source Review (NSR) requirements. • Modifications to improve thermal efficiency can trigger NSR. • Thermal efficiency gains may also be an important strategy for forthcoming CO 2 regulation. • 80% Of non-retiring coal-fired units are projected not to meet minimum NSR requirements. • NSR is an important consideration for the design of CO 2 regulations for existing plants

  2. miR-206 inhibits cell proliferation, migration, and invasion by targeting BAG3 in human cervical cancer.

    Science.gov (United States)

    Wang, Yingying; Tian, Yongjie

    2018-01-02

    miR-206 and bcl2-associated athanogene 3 (BAG3) have been suggested as important regulators in various cancer types. However, the biological role of miR-206 and BAG3 in cervical cancer (CC) remains unclear. Here, we investigated the expressions and mechanisms of miR-206 and BAG3 in cervical cancer using in vitro and in vivo assays. In the present study, miR-206 expression was expressed at a lower level in CC tissues and cells than adjacent normal tissues and NEEC cells. By contrast, BAG3 mRNA and protein were expressed at higher levels in CC tissues and cells. Furthermore, miR-206 overexpression repressed cell proliferation, migration and invasion in vitro, and the 3'-untranslated region (3'-UTR) of BAG3 was a direct target of miR-206. miR-206 overexpression also inhibited EGFR, Bcl-2 and MMP2/9 protein expression, but promoted Bax protein expression. Besides, BAG3 over-expression partially abrogated miR-206-inhibited cell proliferation and invasion, while BAG3 silencing enhanced miR206-mediated inhibition. In vivo assay revealed that miR-206 repressed tumor growth in nude mice xenograft model. In conclusion, miR-206 inhibits cell proliferation, migration, and invasion by targeting BAG3 in human cervical cancer. Thus, miR-206-BAG3 can be used as a useful target for cervical cancer.

  3. Depletion of the cellular levels of Bag-1 proteins attenuates phorbol ester-induced downregulation of IκBα and nuclear accumulation of NF-κB

    International Nuclear Information System (INIS)

    Maier, Jana V.; Volz, Yvonne; Berger, Caroline; Schneider, Sandra; Cato, Andrew C.B.

    2010-01-01

    Research highlights: →Bag-1 depletion only marginally affects the action of the glucocorticoid receptor but strongly regulates the activity of NF-κB. →Bag-1 depletion attenuates phosphorylation and degradation of IκBα and nuclear accumulation of NF-κB p65 and p50. →Bag-1 interacts with IκBα and partially restores IκBα and NF-κB activation in Bag-1 depleted cells. -- Abstract: Bag-1 consists in humans of four isoforms generated from the same RNA by alternative translation. Overexpression of single Bag-1 isoforms has identified Bag-1 as a negative regulator of action of many proteins including the glucocorticoid receptor (GR). Here we have analysed the ability of Bag-1 to regulate the transrepression function of the GR. Silencing Bag-1 expression only marginally affects the transrepression action of the GR but decreased the action of the transcription factor NF-κB. Furthermore phosphorylation and degradation of the inhibitor protein IκBα and nuclear accumulation of p65 and p50 NF-κB proteins in response to phorbol ester was attenuated following Bag-1 depletion in HeLa cells. Reconstitution of Bag-1 in depleted cells partially restored IκBα and NF-κB activation. Knock-down of Bag-1 expression also did not significantly alter GR-mediated transactivation but affected the basal transcription of some of the target genes. Thus Bag-1 proteins function as regulators of the action of selective transcription factors.

  4. Bosonization relations as bag boundary conditions

    International Nuclear Information System (INIS)

    Nadkarni, S.; Nielsen, H.B.; Zahed, I.

    1984-10-01

    The more sophisticated bag models of hadrons become, the less precisely they seem to determine the bag radius. Idealizing this situation leads to the concept of exact bag models - ''Cheshire Cat'' models, CCM'S - where the physics is completely insensitive to changes in the bag radius. CCM's are constructed explitly in 1+1-dimensions, where exact bosonization relations are known. In the formalism of bag models, these relations appear as boundary conditions which ensure that the shifting of the bag wall has no physical effect. Other notable features of 1+1-dimensional CCM's are: (i) Fermion number, though classically confined, can escape the bag via a vector current anomaly at the surface. (ii) Essentially the same boundary action works for a variety of models and its symmetries determine those of the external boson fields. Remarkably enough, this 1+1-dimensional boundary action has precisely the same form as the one used in 3+1-dimensional chiral bag models, lending support to the belief that the latter are indeed approximateCCM's. These 1+1-dimensional results are expected to provide useful guidelines in the attempt to, at least approximately, besonize 3+1-dimensional QCD. (orig.)

  5. PVC posting bags for glove boxes

    International Nuclear Information System (INIS)

    1976-12-01

    This specification covers the materials, measurements and manufacture of unpigmented PVC posting bags for use on glove boxes, together with methods of testing the materials. These bags are used in the handling of radioactive and toxic materials of a hazardous nature and therefore must be of the highest standard of mechanical strength, leak tightness and general finish. (author)

  6. Nuclear matter as an MIT bag crystal

    International Nuclear Information System (INIS)

    Zhang, Q.; Derreth, C.; Schaefer, A.; Greiner, W.

    1986-01-01

    An MIT bag crystal model of nuclear matter is formulated. The energy bands of the quarks are calculated as a function of the overlap between adjacent bags. A clear indication of substantial overlap is found. Accordingly, infinite nuclear matter is more similar to a quark gas than to a nucleonic structure. (author)

  7. Baryon excitations in the bag model

    International Nuclear Information System (INIS)

    Jaffe, R.L.

    1976-07-01

    Two recent spectroscopic applications of the bag model are discussed. The first is a study of the place of multiquark states in meson and baryon spectroscopy, and the second is an attempt to sort out the P-wave baryon excitations in a bag model. 33 references

  8. Workplace Exposure to Titanium Dioxide Nanopowder Released from a Bag Filter System

    Directory of Open Access Journals (Sweden)

    Jun Ho Ji

    2015-01-01

    Full Text Available Many researchers who use laboratory-scale synthesis systems to manufacture nanomaterials could be easily exposed to airborne nanomaterials during the research and development stage. This study used various real-time aerosol detectors to investigate the presence of nanoaerosols in a laboratory used to manufacture titanium dioxide (TiO2. The TiO2 nanopowders were produced via flame synthesis and collected by a bag filter system for subsequent harvesting. Highly concentrated nanopowders were released from the outlet of the bag filter system into the laboratory. The fractional particle collection efficiency of the bag filter system was only 20% at particle diameter of 100 nm, which is much lower than the performance of a high-efficiency particulate air (HEPA filter. Furthermore, the laboratory hood system was inadequate to fully exhaust the air discharged from the bag filter system. Unbalanced air flow rates between bag filter and laboratory hood systems could result in high exposure to nanopowder in laboratory settings. Finally, we simulated behavior of nanopowders released in the laboratory using computational fluid dynamics (CFD.

  9. BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells.

    Science.gov (United States)

    Liu, Bao-Qin; Du, Zhen-Xian; Zong, Zhi-Hong; Li, Chao; Li, Ning; Zhang, Qiang; Kong, De-Hui; Wang, Hua-Qin

    2013-06-01

    Emerging lines of evidence have shown that blockade of ubiquitin-proteasome system (UPS) activates autophagy. The molecular players that regulate the relationship between them remain to be elucidated. Bcl-2 associated athanogene 3 (BAG3) is a member of the BAG co-chaperone family that regulates the ATPase activity of heat shock protein 70 (HSP70) chaperone family. Studies on BAG3 have demonstrated that it plays multiple roles in physiological and pathological processes, including antiapoptotic activity, signal transduction, regulatory role in virus infection, cell adhesion and migration. Recent studies have attracted much attention on its role in initiation of autophagy. The current study, for the first time, demonstrates that proteasome inhibitors elicit noncanonical autophagy, which was not suppressed by inhibitors of class III phosphatidylinositol 3-kinase (PtdIns3K) or shRNA against Beclin 1 (BECN1). In addition, we demonstrate that BAG3 is ascribed to activation of autophagy elicited by proteasome inhibitors and MAPK8/9/10 (also known as JNK1/2/3 respectively) activation is also implicated via upregulation of BAG3. Moreover, we found that noncanonical autophagy mediated by BAG3 suppresses responsiveness of HepG2 cells to proteasome inhibitors.

  10. Strategy for selecting disposable bags for cell culture media applications based on a root-cause investigation.

    Science.gov (United States)

    Wood, Joseph; Mahajan, Ekta; Shiratori, Masaru

    2013-01-01

    The use of disposable bags for cell culture media storage has grown significantly in the past decade. Some of the key advantages of using disposable bags relative to non-disposable containers include increased product throughput, decreased cleaning validation costs, reduced risk of cross contamination and lower facility costs. As the scope of use of disposable bags for cell culture applications increases, problematic bags and scenarios should be identified and addressed to continue improving disposables technologies and meet the biotech industry's needs. In this article, we examine a cell culture application wherein media stored in disposable bags is warmed at 37°C before use for cell culture operations. A problematic bag film was identified through a prospective and retrospective cell culture investigation. The investigation provided information on the scope and variation of the issue with respect to different Chinese hamster ovary (CHO) cell lines, cell culture media, and application-specific parameters. It also led to the development of application-specific test methods and enabled a strategy for disposable bag film testing. The strategy was implemented for qualifying an alternative bag film for use in our processes. In this test strategy, multiple lots of 13 bag film types, encompassing eight vendors were evaluated using a three round, cell culture-based test strategy. The test strategy resulted in the determination of four viable bag film options based on the technical data. The results of this evaluation were used to conclude that a volatile or air-quenched compound, likely generated by gamma irradiation of the problematic bag film, negatively impacted cell culture performance. © 2013 American Institute of Chemical Engineers.

  11. Bag-like contaminant control work module

    International Nuclear Information System (INIS)

    Buchanan, H.; Jacobson, E.B.

    1982-01-01

    A bag-like contaminant control work module is formed from a flexible impervious membrane which is inflated inside of an enclosed workspace to protect workers in the module from contaminants. The workspace, such as in a nuclear power steam generator, has a portal or manway opening into the workspace into which the module is secured by a module passageway. The module includes one or more glove boxes, in which the workers perform their assigned tasks after passing through the passageway and portal. The module includes one or more absolute filters allowing passage of air flow through the module passageway and into the workspace only through the filters. The module may include an auxiliary passageway secured to the outside of the module passageway and also secured in the portal opening and through which items can be passed back and forth to the worker in the glove box from outside the portal. The module is invertible so that it can be pulled out of the workspace trapping all the contaminants therein and disposed of without handling the contaminants

  12. PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells.

    Science.gov (United States)

    Li, N; Du, Z-X; Zong, Z-H; Liu, B-Q; Li, C; Zhang, Q; Wang, H-Q

    2013-09-19

    Protein kinase C delta (PKCδ) is a serine (Ser)/threonine kinase, which regulates numerous cellular processes, including proliferation, differentiation, migration and apoptosis. In the current study, Chinese hamster ovary cells were transfected with either a constitutively activated PKCδ or a dominant negative PKCδ, phosphoprotein enrichment, two-dimensional difference gel electrophoresis and mass spectrometry was combined to globally identified candidates of PKCδ cascade. We found that Bcl-2 associated athanogene 3 (BAG3) was one of the targets of PKCδ cascade, and BAG3 interacted with PKCδ in vivo. In addition, we clarified that BAG3 was phosphorylate at Ser187 site in a PKCδ-dependent manner in vivo. BAG3 has been implicated in multiple cellular functions, including proliferation, differentiation, apoptosis, migration, invasion, macroautophagy and so on. We generated wild-type (WT)-, Ser187Ala (S187A)- or Ser187Asp (S187D)-BAG3 stably expressing FRO cells, and noticed that phosphorylation state of BAG3 influenced FRO morphology. Finally, for the first time, we showed that BAG3 was implicated in epithelial-mesenchymal transition (EMT) procedure, and phosphorylation state at Ser187 site had a critical role in EMT regulation by BAG3. Collectively, the current study indicates that BAG3 is a novel substrate of PKCδ, and PKCδ-mediated phosphorylation of BAG3 is implicated in EMT and invasiveness of thyroid cancer cells.

  13. Water Services in the Buenos Aires Metropolitan Area: How Does State Regulation Work?

    Directory of Open Access Journals (Sweden)

    Mariela Verónica Rocca

    2014-08-01

    Full Text Available This article deals with the State regulation of drinking water and sanitation services in the Metropolitan Area of Buenos Aires. Its main objective is to identify the continuities and ruptures in State regulation during the transition from private management (1993-2006 to renationalisation and State management (2006 onwards. The concept of “State capacities” (both administrative and relational is used to assess regulatory performance. For the administrative capacities, the correspondence between the design and resources of the agencies, as well as the differences between their formal functions and actual practices, is examined. For the relational capacities, the policies of the National Government and its interaction with both the water and sanitation companies and the regulatory and control agencies are considered. The analysis is based on official documents, legislation and statistics, company balance sheets and reports, newspaper articles and semi-structured interviews.

  14. Regulation of hazardous air pollutants emitted from fossil-fired boilers

    International Nuclear Information System (INIS)

    Hendrickson, P.L.; Daellenbach, K.K.

    1993-01-01

    The changes made in section 112 of the Clean Air Act by the 1990 Amendments to the Act will affect the regulation of hazardous air pollutants (HAPs) emitted by fossil-fired boilers. The 1990 Amendments designated 189 chemicals/compounds as HAPS. Major and area sources of these pollutants in categories designated by the Environmental Protection Agency (EPA) will be subject to emission standards set by EPA. Industrial and institutional/commercial boilers are two such categories of HAPs designated by EPA for which emission standards will be issued. Fossil-fired boilers can emit a variety of HAPS. All or a portion of such emissions that exceed designated thresholds are likely to be regulated. This paper discusses how the 1990 amendments impact fossil-fired boilers. The steps are outlined which can be taken by owners of industrial and institutional/commercial boilers before the final emission standards are issued. These steps include participation in EPA's standard setting process, participation in EPA's early reduction program to delay the time when compliance with the maximum achievable control technology (MACT) standard is required, and consideration of any planned modifications to a facility which might subject that facility to a MACT standard set in advance of the EPA-set standard

  15. 16 CFR 501.3 - Replacement bags for vacuum cleaners.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Replacement bags for vacuum cleaners. 501.3... REQUIREMENTS AND PROHIBITIONS UNDER PART 500 § 501.3 Replacement bags for vacuum cleaners. Replacement bags for..., provided: (a) The quantity of contents is expressed in terms of numerical count of the bags; (b) A...

  16. Storage of Maize in Purdue Improved Crop Storage (PICS) Bags.

    Science.gov (United States)

    Williams, Scott B; Murdock, Larry L; Baributsa, Dieudonne

    2017-01-01

    Interest in using hermetic technologies as a pest management solution for stored grain has risen in recent years. One hermetic approach, Purdue Improved Crop Storage (PICS) bags, has proven successful in controlling the postharvest pests of cowpea. This success encouraged farmers to use of PICS bags for storing other crops including maize. To assess whether maize can be safely stored in PICS bags without loss of quality, we carried out laboratory studies of maize grain infested with Sitophilus zeamais (Motshulsky) and stored in PICS triple bags or in woven polypropylene bags. Over an eight month observation period, temperatures in the bags correlated with ambient temperature for all treatments. Relative humidity inside PICS bags remained constant over this period despite the large changes that occurred in the surrounding environment. Relative humidity in the woven bags followed ambient humidity closely. PICS bags containing S. zeamais-infested grain saw a significant decline in oxygen compared to the other treatments. Grain moisture content declined in woven bags, but remained high in PICS bags. Seed germination was not significantly affected over the first six months in all treatments, but declined after eight months of storage when infested grain was held in woven bags. Relative damage was low across treatments and not significantly different between treatments. Overall, maize showed no signs of deterioration in PICS bags versus the woven bags and PICS bags were superior to woven bags in terms of specific metrics of grain quality.

  17. The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease.

    Science.gov (United States)

    Stürner, Elisabeth; Behl, Christian

    2017-01-01

    In neurons, but also in all other cells the complex proteostasis network is monitored and tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly synthesized polypeptides and their refolding upon misfolding the PQC also manages the disposal of aberrant proteins either by the ubiquitin-proteasome machinery or by the autophagic-lysosomal system. Aggregated proteins are primarily degraded by a process termed selective macroautophagy (or aggrephagy). One such recently discovered selective macroautophagy pathway is mediated by the multifunctional HSP70 co-chaperone BAG3 ( BCL-2-associated athanogene 3 ). Under acute stress and during cellular aging, BAG3 in concert with the molecular chaperones HSP70 and HSPB8 as well as the ubiquitin receptor p62/SQSTM1 specifically targets aggregation-prone proteins to autophagic degradation. Thereby, BAG3-mediated selective macroautophagy represents a pivotal adaptive safeguarding and emergency system of the PQC which is activated under pathophysiological conditions to ensure cellular proteostasis. Interestingly, BAG3-mediated selective macroautophagy is also involved in the clearance of aggregated proteins associated with age-related neurodegenerative disorders, like Alzheimer's disease (tau-protein), Huntington's disease (mutated huntingtin/polyQ proteins), and amyotrophic lateral sclerosis (mutated SOD1). In addition, based on its initial description BAG3 is an anti-apoptotic protein that plays a decisive role in other widespread diseases, including cancer and myopathies. Therefore, in the search for novel therapeutic intervention avenues in neurodegeneration, myopathies and cancer BAG3 is a promising candidate.

  18. Electronic Flight Bag (EFB) 2015 Industry Survey.

    Science.gov (United States)

    2015-10-01

    This document provides an overview of Electronic Flight Bag (EFB) hardware and software capabilities, including portable electronic devices (PEDs) used as EFBs, as of July 2015. This document updates and replaces the Volpe Centers previous EFB ind...

  19. Electronic flight bag (EFB) : 2010 industry survey

    Science.gov (United States)

    2010-09-01

    This document provides an overview of Electronic Flight Bag (EFB) systems and capabilities, as of June 2010. This document updates and replaces the April 2007 EFB Industry Review (Yeh and Chandra, 2007). As with the previous industry survey, the focu...

  20. Enhancing Mathematical Communication: "Bag of Tricks" Game

    Science.gov (United States)

    Patahuddin, Sitti Maesuri; Ramful, Ajay; Greenlees, Jane

    2015-01-01

    An engaging activity which prompts students to listen, talk, reason and write about geometrical properties. The "Bag of Tricks" encourages students to clarify their thoughts and communicate precisely using accurate mathematical language.

  1. Multi-monopoles and magnetic bags

    International Nuclear Information System (INIS)

    Bolognesi, Stefano

    2006-01-01

    By analogy with the multi-vortices, we show that also multi-monopoles become magnetic bags in the large n limit. This simplification allows us to compute the spectrum and the profile functions by requiring the minimization of the energy of the bag. We consider in detail the case of the magnetic bag in the limit of vanishing potential and we find that it saturates the Bogomol'nyi bound and there is an infinite set of different shapes of allowed bags. This is consistent with the existence of a moduli space of solutions for the BPS multi-monopoles. We discuss the string theory interpretation of our result and also the relation between the 't Hooft large n limit of certain supersymmetric gauge theories and the large n limit of multi-monopoles. We then consider multi-monopoles in the cosmological context and provide a mechanism that could lead to their production

  2. Design-A-Bag Competition 2012

    Index Scriptorium Estoniae

    2012-01-01

    Eesti Kunstiakadeemia nahakunsti osakonna tudengid Kadri Paloveer, Inga Radikainen ja Mari Maripuu pälvisid Hong-Kongis korraldataval "DESIGN-A-BAG 2012" konkursil tihedas rahvusvahelises konkurentsis mitmeid preemiaid

  3. Models of quark bags and their consequences

    International Nuclear Information System (INIS)

    Bogolubov, P.N.

    1977-01-01

    The development of the first Dubna Quark Bag and the results obtained in this way are considered. The idea of the first Dubna Quark Bag is as follows: baryons are constructed of three quarks measons are constructed of two quarks, and each quark is interpreted as the Dirac particle which moves in a scalar square well. The so-called quasiindependent quark model is considered too. It is a simple quark model based on an analogy with the shell model for nuclei. The quarks are considered as moving in an arbitrary radially-symmetric field, and their one-particle wave function satisfies the usual Dirac equation. Such quark model can give at least the same results as the relativistic bag model. A possibility exists to improve the results of the relativistic quark model with the oscillator interaction between quarks. The results of the MIT-Bag model and the quasiindependent quark model coincide

  4. Nuclear surface vibrations in bag models

    International Nuclear Information System (INIS)

    Tomio, L.

    1984-01-01

    The main difficulties found in the hadron bag models are reviewed from the original version of the MIT bag model. Following, with the aim to answer two of the main difficulties in bag models, viz., the parity and the divergence illness, a dynamical model is presented. In the model, the confinement surface of the quarks (bag) is treated like a real physical object which interacts with the quarks and is exposed to vibrations. The model is applied to the nucleon, being observed that his spectrum, in the first excited levels, can be reproduced with resonable precision and obeying to the correct parity order. In the same way that in a similar work of Brown et al., it is observed to be instrumental the inclusion of the effect due to pions. (L.C.) [pt

  5. PLASTIC BAGS: AQUESTION OF CHANGING HABITS

    OpenAIRE

    Lorenzett, Juliana Benitti; Rizzatti, Cláudia Bach; Lorenzett, Daniel Benitti; Godoy, Leoni Pentiado

    2013-01-01

    http://dx.doi.org/10.5902/223613087725This study aimed to conduct a review about of the use and disposal of plastic bags, checking in the existing literature that has been studied and the current status of this environmental problem, besides conducting a survey with customers in a supermarket to check the involvement of the community with the adoption of reusable bags. A bibliographic search was conducted by internet, and is considered therefore works available online. The study survey was gi...

  6. An alternative approach to heavy quark bags

    International Nuclear Information System (INIS)

    Baacke, J.; Kasperidus, G.

    1980-01-01

    We discuss a formulation of quark bags where the quark wave function depends only on the relative coordinate and the bag boundary is fixed with respect to the center of mass of the quark system. For technical reasons we have to restrict ourselves to a heavy quark-antiquark system in an s-wave with spherical boundary. A phenomenological application to quarkonium states encourages further investigation of the approach. (orig.)

  7. Ethylene sensitivity and relative air humidity regulate root hydraulic properties in tomato plants.

    Science.gov (United States)

    Calvo-Polanco, Monica; Ibort, Pablo; Molina, Sonia; Ruiz-Lozano, Juan Manuel; Zamarreño, Angel María; García-Mina, Jose María; Aroca, Ricardo

    2017-11-01

    The effect of ethylene and its precursor ACC on root hydraulic properties, including aquaporin expression and abundance, is modulated by relative air humidity and plant sensitivity to ethylene. Relative air humidity (RH) is a main factor contributing to water balance in plants. Ethylene (ET) is known to be involved in the regulation of root water uptake and stomatal opening although its role on plant water balance under different RH is not very well understood. We studied, at the physiological, hormonal and molecular levels (aquaporins expression, abundance and phosphorylation state), the plant responses to exogenous 1-aminocyclopropane-1-carboxylic acid (ACC; precursor of ET) and 2-aminoisobutyric acid (AIB; inhibitor of ET biosynthesis), after 24 h of application to the roots of tomato wild type (WT) plants and its ET-insensitive never ripe (nr) mutant, at two RH levels: regular (50%) and close to saturation RH. Highest RH induced an increase of root hydraulic conductivity (Lp o ) of non-treated WT plants, and the opposite effect in nr mutants. The treatment with ACC reduced Lp o in WT plants at low RH and in nr plants at high RH. The application of AIB increased Lp o only in nr plants at high RH. In untreated plants, the RH treatment changed the abundance and phosphorylation of aquaporins that affected differently both genotypes according to their ET sensitivity. We show that RH is critical in regulating root hydraulic properties, and that Lp o is affected by the plant sensitivity to ET, and possibly to ACC, by regulating aquaporins expression and their phosphorylation status. These results incorporate the relationship between RH and ET in the response of Lp o to environmental changes.

  8. Stability of Fentanyl Citrate in Polyolefin Bags.

    Science.gov (United States)

    Donnelly, Ronald F

    2016-01-01

    Fentanyl is used to manage pain because it is a potent lipophilic opiate agonist. The stability of fentanyl in polyolefin bags when diluted to either 10 µg/mL or 50 µg/mL with sodium chloride 0.9% has not been studied. The chemical stability of fentanyl 50 µg/mL packaged in polyvinyl chloride bags has been studied, however, the stability in polyolefin bags is lacking. Polyolefin bags were aseptically filled with either 10-µg/mL or 50-µg/mL fentanyl solution. Containers were then stored at either 5°C and protected from light or 22°C and exposed to light for 93 days. Fentanyl peaks were monitored using a stability-indicatin high-performance liquid chromatographic method. Changes to color, clarity, and pH were also monitored. There were no signs of chemical degradation of fentanyl packaged in polyolefin bags at either 5°C or 22°C after storage for 93 days. Over the course of the study, all solutions remained colorless and clear. The pH showed a slight decrease during the 93 days of storage. The stability of both undiluted (50-µg/mL) and diluted (10-µg/mL) fentanyl solutions when packaged in polyolefin bags was 93 days when stored at either 5°C or 22°C. Copyright© by International Journal of Pharmaceutical Compounding, Inc.

  9. Behavioral Response to Plastic Bag Legislation in Botswana

    OpenAIRE

    Dikgang, Johane; Visser, Martine

    2010-01-01

    This paper investigates the use of charges and standards in dealing with a common externality, plastic litter from shopping bags in Botswana. The country passed a plastic bag tax (effective 2007) to curb the plastic bag demand. Interestingly, the legislation did not force retailers to charge for plastic bags, which they did voluntarily at different prices. We assessed the environmental effectiveness and efficiency of the plastic bag legislation by analyzing consumers’ sensitivity to the impro...

  10. The quark mass and baryon numbers of empty chiral bags

    International Nuclear Information System (INIS)

    Jezabek, M.; Zalewski, K.

    1984-01-01

    We show that for spherical chiral bags the baryon number of the Dirac vacuum inside the bag does not depend on quark masses. Thus, the sum of the baryon numbers of an empty chiral bag and the skyrmion surrounding the bag is an integer, which depends on the boundary condition on the surface of the bag. This extends the result obtained by Goldstone and Jaffe for massless quarks. (orig.)

  11. Swelling and infusion of tea in tea bags.

    Science.gov (United States)

    Yadav, Geeta U; Joshi, Bhushan S; Patwardhan, Ashwin W; Singh, Gurmeet

    2017-07-01

    The present study deals with swelling and infusion kinetics of tea granules in tea bags. The swelling and infusion kinetics of tea bags differing in tea loading and tea bag shapes were compared with loose tea. Increment in temperature and dipping frequency of tea bag in hot water increased the infusion kinetics of tea bags. Reduction in particle size enhanced the swelling and infusion kinetics of tea in a tea bag. The effects of tea particle size, tea bag dipping rate, loading of tea granules in tea bag and tea bag shapes on infusion kinetics were investigated. Increase in tea loading in tea bags resulted in reduced infusion kinetics. Double chambered tea bag showed the highest swelling (30%) and infusion kinetics (8.30% Gallic acid equivalence) while single chambered tea bags showed the lowest kinetics, amongst the various bags studied. The swelling and infusion kinetics of loose tea was always faster and higher than that of tea bags. It was found that overall effect of percentage filling of tea granules and height of tea bed in a tea bag affects tea infusion kinetics the most. Weibull model was found to be in good agreement with the swelling data.

  12. Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737.

    Science.gov (United States)

    Mani, Jens; Antonietti, Patrick; Rakel, Stefanie; Blaheta, Roman; Bartsch, Georg; Haferkamp, Axel; Kögel, Donat

    2016-02-01

    BAG3 is overexpressed in several malignancies and mediates a non-canonical, selective form of (macro)autophagy. By stabilizing pro-survival Bcl-2 proteins in complex with HSP70, BAG3 can also exert an apoptosis-antagonizing function. ABT-737 is a high affinity Bcl-2 inhibitor that fails to target Mcl-1. This failure may confer resistance in various cancers. Urothelial cancer cells were treated with the BH3 mimetics ABT-737 and (-)-gossypol, a pan-Bcl-2 inhibitor which inhibits also Mcl-1. To clarify the importance of the core autophagy regulator ATG5 and BAG3 in ABT-737 treatment, cell lines carrying a stable lentiviral knockdown of ATG5 and BAG3 were created. The synergistic effect of ABT-737 and pharmaceutical inhibition of BAG3 with the HSF1 inhibitor KRIBB11 or sorafenib was also evaluated. Total cell death and apoptosis were quantified by FACS analysis of propidium iodide, annexin. Target protein analysis was conducted by Western blotting. Knockdown of BAG3 significantly downregulated Mcl-1 protein levels and sensitized urothelial cancer cells to apoptotic cell death induced by ABT-737, while inhibition of bulk autophagy through depletion of ATG5 had no discernible effect on cell death. Similar to knockdown of BAG3, pharmacological targeting of the BAG3/Mcl-1 pathway with KRIBB11 was capable to sensitize both cell lines to treatment with ABT-737. Our results show that BAG3, but not bulk autophagy has a major role in the response of bladder cancer cells to BH3 mimetics. They also suggest that BAG3 is a suitable target for combined therapies aimed at synergistically inducing apoptosis in bladder cancer.

  13. Performance testing of the new AMPAC fire debris bag against three other commercial fire debris bags.

    Science.gov (United States)

    Grutters, Michiel M P; Dogger, Judith; Hendrikse, Jeanet N

    2012-09-01

    Fire debris evidence is collected and stored in a wide range of containers, including various polymer bags. Four different polymer bags have been investigated, including the NYLON, DUO, ALU, and AMPAC bags. The latter is the successor of the Kapak Fire DebrisPAK™. Microscopy and infrared spectroscopy were used to elucidate the composition of the bags. Gas chromatography/mass spectrometry was used to investigate performance parameters such as background volatiles, leak rate, cross-contamination, recovery, and sorption. The NYLON bag was susceptible for leakage and cross-contamination and showed decreased recoveries. The DUO and ALU bags showed some background volatiles, sorption, and poor recoveries. The AMPAC bag performed excellent: low background, no leakage or cross-contamination, good recoveries, and only traces of sorption. Heat sealing proved to be the best method of closure. Preliminary studies on AMPAC bags showed that polyethylene clamps are easy to use on-site and preserve ignitable liquids adequately for a limited period of time. © 2012 American Academy of Forensic Sciences.

  14. Modeling of a New Structure of Precision Air Conditioning System Using Secondary Condenser for Rh Regulation

    Directory of Open Access Journals (Sweden)

    Aries Subiantoro

    2012-05-01

    Full Text Available A dynamic mathematical model for a new structure of precision air conditioning (PAC has been developed. The proposed PAC uses an additional secondary condenser for relative humidity regulation compared to a basic refrigeration system. The work mechanism for this system and a vapour-compression cycle process of the system are illustrated using psychrometric chart and pressure-enthalpy diagram. A non-linear system model is derived based on the conservation of mass and energy balance principles and then linearized at steady state operating point for developing a 8th-order state space model suited for multivariable controller design. The quality of linearized model is analyzed in terms of transient response, controllability, observability, and interaction between input-output variables. The developed model is verified through simulation showing its ability for imitating the nonlinear behavior and the interaction of input-output variables.

  15. Safety and durability of low-density polyethylene bags in solar water disinfection applications.

    Science.gov (United States)

    Danwittayakul, Supamas; Songngam, Supachai; Fhulua, Tipawan; Muangkasem, Panida; Sukkasi, Sittha

    2017-08-01

    Solar water disinfection (SODIS) is a simple point-of-use process that uses sunlight to disinfect water for drinking. Polyethylene terephthalate (PET) bottles are typically used as water containers for SODIS, but a new SODIS container design has recently been developed with low-density polyethylene (LDPE) bags and can overcome the drawbacks of PET bottles. Two nesting layers of LDPE bags are used in the new design: the inner layer containing the water to be disinfected and the outer one creating air insulation to minimize heat loss from the water to the surroundings. This work investigated the degradation of LDPE bags used in the new design in actual SODIS conditions over a period of 12 weeks. The degradation of the LDPE bags was investigated weekly using a scanning electron microscope, Fourier transform infrared spectroscopy, ultraviolet-visible spectrophotometer, and tensile strength tester. It was found that the LDPE bags gradually degraded under the sunlight due to photo-oxidation reactions, especially in the outer bags, which were directly exposed to the sun and surroundings, leading to the reduction of light transmittance (by 11% at 300 nm) and tensile strength (by 33%). In addition, possible leaching of organic compounds into the water contained in the inner bags was examined using gas chromatography-mass spectrometer. 2,4-Di-tert-butylphenol was found in some SODIS water samples as well as the as-received water samples, in the concentration range of 1-4 μg/L, which passes the Environmental Protection Agency Drinking Water Guidance on Disinfection By-Products.

  16. 7Be content and its seasonal regulation in the ground air around Hangzhou area

    International Nuclear Information System (INIS)

    Jiang Rangrong

    1995-01-01

    In twice investigations around Hangzhou, it is indicated that 7 Be concentration in the ground air is averagely 5.9 mBq/m 3 which is 130% higher than that in Germany reported by UNSCEAR. The highest level is in autumn-winter over a year reaching 7.7 mBq/m 3 ; the next is in spring reaching 6.2 mBq/m 3 ; the middle is 5.7 mBq/m 3 in early summer approaching to the yearly average level; and the lowest in a year is in summer-autumn that is 3.8 mBq/m 3 . It presents a decreasing regulation from autumn-winter to summer-autumn of the next year, and is basically consistent with the seasonal variation of the rainfall in Hangzhou area, but does not present the variation reported by UNSCEAR that it was the highest in spring and the lowest in late autumn basing on 7 Be falling down from the stratosphere. It shows that the process of rainfall is the main reason effecting 7 Be content in the air. Comparing to 222 Rn, the annual absorption dose produced by 7 Be can be neglected

  17. Research on Vehicle Temperature Regulation System Based on Air Convection Principle

    Science.gov (United States)

    Zhuge, Muzi; Li, Xiang; Liang, Caifeng

    2018-03-01

    The long time parking outdoors in the summer will lead to too high temperature in the car, and the harmful gas produced by the vehicle engine will stay in the confined space for a long time during the parking process, which will do great harm to the human body. If the air conditioning system is turned on before driving, the cooling rate is slow and the battery loss is large. To solve the above problems, we designed a temperature adjusting system based on the principle of air convection. We can choose the automatic mode or manual mode to achieve control of a convection window. In the automatic mode, the system will automatically detect the environmental temperature, through the sensor to complete the detection, and the signal is transmitted to the microcontroller to control the window open or close, in manual mode, the remote control of the window can be realized by Bluetooth. Therefore, the system has important practical significance to effectively regulate temperature, prolong battery life, and improve the safety and comfort of traffic vehicles.

  18. The first survey of airborne trace elements at airport using moss bag technique.

    Science.gov (United States)

    Vuković, Gordana; Urošević, Mira Aničić; Škrivanj, Sandra; Vergel, Konstantin; Tomašević, Milica; Popović, Aleksandar

    2017-06-01

    Air traffic represents an important way of social mobility in the world, and many ongoing discussions are related to the impacts that air transportation has on local air quality. In this study, moss Sphagnum girgensohnii was used for the first time in the assessment of trace element content at the international airport. The moss bags were exposed during the summer of 2013 at four sampling sites at the airport 'Nikola Tesla' (Belgrade, Serbia): runway (two), auxiliary runway and parking lot. According to the relative accumulation factor (RAF) and the limit of quantification of the moss bag technique (LOQ T ), the most abundant elements in the samples were Zn, Na, Cr, V, Cu and Fe. A comparison between the element concentrations at the airport and the corresponding values in different land use classes (urban central, suburban, industrial and green zones) across the city of Belgrade did not point out that the air traffic and associated activities significantly contribute to the trace element air pollution. This study emphasised an easy operational and robust (bio)monitoring, using moss bags as a suitable method for assessment of air quality within various microenvironments with restriction in positioning referent instrumental devices.

  19. Alternative hospital gift bags and breastfeeding exclusivity.

    Science.gov (United States)

    Bai, Yeon; Wunderlich, Shahla M; Kashdan, Rickie

    2013-01-01

    The type of gift bags given to new mothers at the time of discharge from the hospital can influence their confidence in breastfeeding. Most hospitals in the US continue to distribute commercial gift bags containing formula samples despite the reported negative influence of commercial bags on the duration of breastfeeding. This study compared breastfeeding outcomes in women receiving three different kinds of gift bags at discharge. A prospective intervention study was conducted during 2009-2010 in New Jersey. Three breastfeeding cohorts were recruited and assigned to three groups: COMMERCIAL received discharge bags containing formula samples, BF-INFO received breastfeeding information and supplies, and PUMP received breastfeeding information/supplies plus a manual breast pump. Follow-up contacts were at 2, 4, and 12 postpartum weeks to determine breastfeeding outcome. The mean durations of exclusive (EBF) and partial breastfeeding were compared between groups using ANOVA. A total of 386 participants completed the study. The mean EBF duration (weeks) in the PUMP (n = 138, 8.28 ± 4.86) and BF-INFO (n = 121, 7.87 ± 4.63) were significantly longer (P < 0.01) than COMMERCIAL (n = 127, 6.12 ± 4.49). The rate of EBF through 12 weeks in PUMP was most consistent. The mean duration of partial breastfeeding showed similar results: significantly longer in PUMP and BF-INFO than COMMERCIAL (P < 0.01).

  20. Baryon bags in strong coupling QCD

    Science.gov (United States)

    Gattringer, Christof

    2018-04-01

    We discuss lattice QCD with one flavor of staggered fermions and show that in the path integral the baryon contributions can be fully separated from quark and diquark contributions. The baryonic degrees of freedom (d.o.f.) are independent of the gauge field, and the corresponding free fermion action describes the baryons through the joint propagation of three quarks. The nonbaryonic dynamics is described by quark and diquark terms that couple to the gauge field. When evaluating the quark and diquark contributions in the strong coupling limit, the partition function completely factorizes into baryon bags and a complementary domain. Baryon bags are regions in space-time where the dynamics is described by a single free fermion made out of three quarks propagating coherently as a baryon. Outside the baryon bags, the relevant d.o.f. are monomers and dimers for quarks and diquarks. The partition sum is a sum over all baryon bag configurations, and for each bag, a free fermion determinant appears as a weight factor.

  1. A miniaturized piezoelectric turbine with self-regulation for increased air speed range

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Hailing, E-mail: h.fu14@imperial.ac.uk; Yeatman, Eric M. [Department of Electrical and Electronic Engineering, Imperial College London, London SW7 2AZ (United Kingdom)

    2015-12-14

    This paper presents the design and demonstration of a piezoelectric turbine with self-regulation for increased air speed range. The turbine's transduction is achieved by magnetic “plucking” of a piezoelectric beam by the passing rotor. The increased speed range is achieved by the self-regulating mechanism which can dynamically adjust the magnetic coupling between the magnets on the turbine rotor and the piezoelectric beam using a micro-spring. The spring is controlled passively by the centrifugal force of the magnet on the rotor. This mechanism automatically changes the relative position of the magnets at different rotational speeds, making the coupling weak at low airflow speeds and strong at high speeds. Hence, the device can start up with a low airflow speed, and the output power can be ensured when the airflow speed is high. A theoretical model was established to analyse the turbine's performance, advantages, and to optimize its design parameters. A prototype was fabricated and tested in a wind tunnel. The start-up airflow speed was 2.34 m/s, showing a 30% improvement against a harvester without the mechanism.

  2. A miniaturized piezoelectric turbine with self-regulation for increased air speed range

    International Nuclear Information System (INIS)

    Fu, Hailing; Yeatman, Eric M.

    2015-01-01

    This paper presents the design and demonstration of a piezoelectric turbine with self-regulation for increased air speed range. The turbine's transduction is achieved by magnetic “plucking” of a piezoelectric beam by the passing rotor. The increased speed range is achieved by the self-regulating mechanism which can dynamically adjust the magnetic coupling between the magnets on the turbine rotor and the piezoelectric beam using a micro-spring. The spring is controlled passively by the centrifugal force of the magnet on the rotor. This mechanism automatically changes the relative position of the magnets at different rotational speeds, making the coupling weak at low airflow speeds and strong at high speeds. Hence, the device can start up with a low airflow speed, and the output power can be ensured when the airflow speed is high. A theoretical model was established to analyse the turbine's performance, advantages, and to optimize its design parameters. A prototype was fabricated and tested in a wind tunnel. The start-up airflow speed was 2.34 m/s, showing a 30% improvement against a harvester without the mechanism

  3. BAG3-related myopathy, polyneuropathy and cardiomyopathy with long QT syndrome.

    Science.gov (United States)

    Kostera-Pruszczyk, Anna; Suszek, Małgorzata; Płoski, Rafał; Franaszczyk, Maria; Potulska-Chromik, Anna; Pruszczyk, Piotr; Sadurska, Elżbieta; Karolczak, Justyna; Kamińska, Anna M; Rędowicz, Maria Jolanta

    2015-12-01

    BAG3 belongs to BAG family of molecular chaperone regulators interacting with HSP70 and anti-apoptotic protein Bcl-2. It is ubiquitously expressed with strong expression in skeletal and cardiac muscle, and is involved in a panoply of cellular processes. Mutations in BAG3 and aberrations in its expression cause fulminant myopathies, presenting with progressive limb and axial muscle weakness, and respiratory insufficiency and neuropathy. Herein, we report a sporadic case of a 15-years old girl with symptoms of myopathy, demyelinating polyneuropathy and asymptomatic long QT syndrome. Genetic testing demonstrated heterozygous mutation Pro209Leu (c.626C > T) in exon 3 of BAG3 gene causing severe myopathy and neuropathy, often associated with restrictive cardiomyopathy. We did not find a mutation in any known LQT syndrome genes. Analysis of muscle biopsy revealed profound disintegration of Z-discs with extensive accumulation of granular debris and large inclusions within fibers. We demonstrated profound alterations in BAG3 distribution as the protein localized to long filamentous structures present across the fibers that were positively stained not only for α-actinin but also for desmin and filamin indicating that those disintegrated Z-disc regions contained also other sarcomeric proteins. The mutation caused a decrease in the content of BAG3 and HSP70, and also of α-actinin desmin, filamin and fast myosin heavy chain, confirming its severe effect on the muscle fiber morphology and thus function. We provide further evidence that BAG3 is associated with Z-disc maintenance, and the Pro209Leu mutation may occur worldwide. We also provide a summary of cases associated with this mutation reported so far.

  4. Solid and Liquid Waste Drying Bag

    Science.gov (United States)

    Litwiller, Eric (Inventor); Hogan, John A. (Inventor); Fisher, John W. (Inventor)

    2009-01-01

    Method and system for processing waste from human activities, including solids, liquids and vapors. A fluid-impermeable bag, lined with a liquid-impermeable but vapor-permeable membrane, defining an inner bag, is provided. A vacuum force is provided to extract vapors so that the waste is moved toward a selected region in the inner bag, extracted vapors, including the waste vapors and vaporized portions of the waste liquids are transported across the membrane, and most or all of the solids remain within the liner. Extracted vapors are filtered, and sanitized components thereof are isolated and optionally stored. The solids remaining within the liner are optionally dried and isolated for ultimate disposal.

  5. EMC effect and multiquark bags in nuclei

    International Nuclear Information System (INIS)

    Kondratyuk, L.; Shmatikov, M.

    1984-01-01

    Assuming existence of 9q- and 12q bags in niclei the form factors of light nuclei at large momentum transfers and structure functions of deep inelastic scattering of leptons on nuclei are described. It is shown that the existing experimental data can be described in a unified way provided the momentum distribution of quarks in multiquark bags at k 0 has the exponential form PSIsub(q)sup(2)(k) approximately esup(-k/k 0 ) with the parameter k 0 approximately 50-60 MeV. Theoretical results agree well the EMC experimental data on the ratio of the iron and deuteron structure functions with the 20% admixture of 12q-bags in the Fe nucleus

  6. A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis.

    Science.gov (United States)

    Fuchs, Margit; Luthold, Carole; Guilbert, Solenn M; Varlet, Alice Anaïs; Lambert, Herman; Jetté, Alexandra; Elowe, Sabine; Landry, Jacques; Lavoie, Josée N

    2015-10-01

    The co-chaperone BAG3, in complex with the heat shock protein HSPB8, plays a role in protein quality control during mechanical strain. It is part of a multichaperone complex that senses damaged cytoskeletal proteins and orchestrates their seclusion and/or degradation by selective autophagy. Here we describe a novel role for the BAG3-HSPB8 complex in mitosis, a process involving profound changes in cell tension homeostasis. BAG3 is hyperphosphorylated at mitotic entry and localizes to centrosomal regions. BAG3 regulates, in an HSPB8-dependent manner, the timely congression of chromosomes to the metaphase plate by influencing the three-dimensional positioning of the mitotic spindle. Depletion of BAG3 caused defects in cell rounding at metaphase and dramatic blebbing of the cortex associated with abnormal spindle rotations. Similar defects were observed upon silencing of the autophagic receptor p62/SQSTM1 that contributes to BAG3-mediated selective autophagy pathway. Mitotic cells depleted of BAG3, HSPB8 or p62/SQSTM1 exhibited disorganized actin-rich retraction fibres, which are proposed to guide spindle orientation. Proper spindle positioning was rescued in BAG3-depleted cells upon addition of the lectin concanavalin A, which restores cortex rigidity. Together, our findings suggest the existence of a so-far unrecognized quality control mechanism involving BAG3, HSPB8 and p62/SQSTM1 for accurate remodelling of actin-based mitotic structures that guide spindle orientation.

  7. A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis.

    Directory of Open Access Journals (Sweden)

    Margit Fuchs

    2015-10-01

    Full Text Available The co-chaperone BAG3, in complex with the heat shock protein HSPB8, plays a role in protein quality control during mechanical strain. It is part of a multichaperone complex that senses damaged cytoskeletal proteins and orchestrates their seclusion and/or degradation by selective autophagy. Here we describe a novel role for the BAG3-HSPB8 complex in mitosis, a process involving profound changes in cell tension homeostasis. BAG3 is hyperphosphorylated at mitotic entry and localizes to centrosomal regions. BAG3 regulates, in an HSPB8-dependent manner, the timely congression of chromosomes to the metaphase plate by influencing the three-dimensional positioning of the mitotic spindle. Depletion of BAG3 caused defects in cell rounding at metaphase and dramatic blebbing of the cortex associated with abnormal spindle rotations. Similar defects were observed upon silencing of the autophagic receptor p62/SQSTM1 that contributes to BAG3-mediated selective autophagy pathway. Mitotic cells depleted of BAG3, HSPB8 or p62/SQSTM1 exhibited disorganized actin-rich retraction fibres, which are proposed to guide spindle orientation. Proper spindle positioning was rescued in BAG3-depleted cells upon addition of the lectin concanavalin A, which restores cortex rigidity. Together, our findings suggest the existence of a so-far unrecognized quality control mechanism involving BAG3, HSPB8 and p62/SQSTM1 for accurate remodelling of actin-based mitotic structures that guide spindle orientation.

  8. Zero-point energy in bag models

    International Nuclear Information System (INIS)

    Milton, K.A.

    1979-01-01

    The zero-point (Casimir) energy of free vector (gluon) fields confined to a spherical cavity (bag) is computed. With a suitable renormalization the result for eight gluons is E = + 0.51/a. This result is substantially larger than that for a spherical shell (where both interior and exterior modes are present), and so affects Johnson's model of the QCD vacuum. It is also smaller than, and of opposite sign to, the value used in bag model phenomenology, so it will have important implications there. 1 figure

  9. Modern status of quark bag model

    International Nuclear Information System (INIS)

    Bogolyubov, P.N.; Dorokhov, A.E.

    1987-01-01

    A review contains a modern status of the bag model - a composite quark model of hadrons. The idea of quasi-independent quarks moving in a finite closed region of space is a basic feature of the model. Dubna's formulation of the model and its different versions (MIT, chiral model and others) are given in detail. The role of symmetric and physical principles of the model is underlined, a critical review of mass formulas is given, the relation of the bag model and the soliton-like models (in particular with the Skyrme model) is considered

  10. Waste product profile: Plastic film and bags

    Energy Technology Data Exchange (ETDEWEB)

    Miller, C. [Environmental Industry Associations, Washington, DC (United States)

    1996-10-01

    Plastic film is recycled by being pelletized following a granulation or densifying process. Manufacturing and converting plants are the major sources of plastic film for recycling because they can supply sufficient amounts of clean raw material of a known resin type. Post-consumer collection programs are more recent. They tend to focus on businesses such as grocery stores that are large generators of plastic bags. In this case, the recycling process is more complex, requiring sorting, washing, and removal of contaminants as a first step. Curbside collection of plastic bags is rare.

  11. Labor development strategy in the bag industry

    Directory of Open Access Journals (Sweden)

    Dyah Maya Nihayah

    2016-04-01

    Full Text Available The research aims to formulate strategies for improving the labor competencies in the bag industry in Kudus Regency. The data comprise business players, which will be analyzed using the Strength, Weaknesses, Opportunities, and Threats (SWOT analysis. The results reveal that the proper strategy for improving employment in the bag industry is growth and build strategy. Growth and development strategy are intensive actions undertaken through the development of labor competencies to improve the quality of output. It can be made with creating learning resources by designing methods and trainings refer to the Competency Based Training (CBT.

  12. Solar saddle bags. Solar-Fahrradpacktaschen

    Energy Technology Data Exchange (ETDEWEB)

    Willems, M

    1991-09-12

    The invention consists of the arrangement of solar cells on the upper side of saddle bags of every design (handle bar pocket, bicycle saddle bag etc.) which charge the accumulators in the pack pocket. One can drive the alternator of the bicycle, a transistor radio, a cassette tape recorder, or similar, with the power from the accumulators. The lamp and the taillight of the bicycle can still be used. The solar cells can be attached firmly to the pack pocket. However, they can also be assembled detachably, e.g. by push-buttons or zip-fasteners.

  13. microRNA-340 induces apoptosis by downregulation of BAG3 in ovarian cancer SKOV3 cells.

    Science.gov (United States)

    Qu, Fei; Wang, Xiufen

    2017-08-01

    Aberrant expression of miR-340 has been found in several kinds of cancers including ovarian cancer. Pro-apoptotic and anti-metastasis roles of miR-340 in ovarian cancer have also been reported; however, the underling molecular mechanisms by which miR-340 suppresses ovarian cancer are still unclear. This study focused on the role and molecular mechanism of miR-340 in ovarian cancer. Human ovarian carcinoma SKOV3 cells were used and transfected with miR-340 mimic, miR-340 inhibitor and their correspondingly negative controls (mimic control and inhibitor control). Thereafter, cell viability, apoptosis, and the expressions of apoptosis-associated factors and BAG3 were respectively assessed by MTT assay, flow cytometry, qRT-PCR and Western blotting. SKOV3 cells were then co-transfected with miR-340 inhibitor and BAG3 targeted siRNA, then cell viability, apoptosis and the expression of apoptosis-associated factors were retested. Besides, the expressions of main factors in PI3K/AKT pathway were detected. Overexpression of miR-340 suppressed BAG3 cells viability (P BAG3 was negatively regulated by miR-340 (P BAG3 silence significantly induced cell apoptosis (P BAG3 silence abolished miR-340 suppression-induced activation of PI3K and AKT. This study revealed the tumor suppressive role of miR-340 in SKOV3 cells by negative regulation of BAG3. PI3K/AKT pathway might be involved in the regulation of miR-340 and BAG3.

  14. Effects of agriculture upon the air quality and climate: research, policy, and regulations.

    Science.gov (United States)

    Aneja, Viney P; Schlesinger, William H; Erisman, Jan Willem

    2009-06-15

    compounds, volatile organic compounds, greenhouse gases, odor and pathogens, the quantification of landscape processes, and the primary and secondary emissions of PM. Given the serious concerns raised regarding the amount and the impacts of agricultural air emissions, policies must be pursued and regulations must be enacted in orderto make real progress in reducing these emissions and their associated environmental impacts.

  15. Fragment size distribution in viscous bag breakup of a drop

    Science.gov (United States)

    Kulkarni, Varun; Bulusu, Kartik V.; Plesniak, Michael W.; Sojka, Paul E.

    2015-11-01

    In this study we examine the drop size distribution resulting from the fragmentation of a single drop in the presence of a continuous air jet. Specifically, we study the effect of Weber number, We, and Ohnesorge number, Oh on the disintegration process. The regime of breakup considered is observed between 12 phase Doppler anemometry. Both the number and volume fragment size probability distributions are plotted. The volume probability distribution revealed a bi-modal behavior with two distinct peaks: one corresponding to the rim fragments and the other to the bag fragments. This behavior was suppressed in the number probability distribution. Additionally, we employ an in-house particle detection code to isolate the rim fragment size distribution from the total probability distributions. Our experiments showed that the bag fragments are smaller in diameter and larger in number, while the rim fragments are larger in diameter and smaller in number. Furthermore, with increasing We for a given Ohwe observe a large number of small-diameter drops and small number of large-diameter drops. On the other hand, with increasing Oh for a fixed We the opposite is seen.

  16. Impact of sulfur content regulations of shipping fuel on coastal air quality

    Science.gov (United States)

    Seyler, André; Wittrock, Folkard; Kattner, Lisa; Mathieu-Üffing, Barbara; Weigelt, Andreas; Peters, Enno; Richter, Andreas; Schmolke, Stefan; Burrows, John P.

    2016-04-01

    Shipping traffic is a sector that faces an enormous growth rate and contributes substantially to the emissions from the transportation sector, but lacks regulations and controls. Shipping is not enclosed in the Kyoto Protocol. However, the International Maritime Organization (IMO) introduced sufhur limits for marine heavy fuels, nitrogen oxide limits for newly-built ship engines and established Emission Control Areas (ECA) in the North and Baltic Sea as well as around North America with the International Convention for the Prevention of Pollution from Ships (MARPOL 73/78 Annex VI). Recently, on the 1st of January 2015, the allowed sulfur content of marine fuels inside Sulfur Emission Control Areas has been significantly decreased from 1.0% to 0.1%. However, measurements of reactive trace gases and the chemical composition of the marine troposphere along shipping routes are sparse and up to now there is no regular monitoring system available. The project MeSmarT (measurements of shipping emissions in the marine troposphere) is a cooperation between the University of Bremen, the German Federal Maritime and Hydrographic Agency (Bundesamt für Seeschifffahrt und Hydrographie, BSH) and the Helmholtz-Zentrum Geesthacht. This study aims to analyse the influence of shipping emissions on the coastal air quality by evaluating ground-based remote sensing measurements using the MAX-DOAS (Multi AXis Differential Optical Absorption Spectroscopy) technique. Measurements of the atmospheric trace gases nitrogen dioxide (NO2) and sulfur dioxide (SO2) have been carried out in the marine troposphere at the MeSmarT measurement sites in Wedel and on Neuwerk and on-board several ship cruises on the North and Baltic Sea. The capability of two-channel MAX-DOAS systems to do simultaneous measurements in the UV and visible spectral range has been used in the so called "onion-peeling" approach to derive spatial distributions of ship emissions and to analyse the movement of the exhausted

  17. Compact assembly generates plastic foam, inflates flotation bag

    Science.gov (United States)

    1965-01-01

    Device for generating plastic foam consists of an elastomeric bag and two containers with liquid resin and a liquid catalyst. When the walls of the containers are ruptured the liquids come into contact producing foam which inflates the elastomeric bag.

  18. BAG3 protects against hyperthermic stress by modulating NF-κB and ERK activities in human retinoblastoma cells.

    Science.gov (United States)

    Yunoki, Tatsuya; Tabuchi, Yoshiaki; Hayashi, Atsushi; Kondo, Takashi

    2015-03-01

    BCL2-associated athanogene 3 (BAG3), a co-chaperone of HSP70, is a cytoprotective and anti-apoptotic protein that acts against various stresses, including heat stress. Here, we examined the effect of BAG3 on the sensitivity of human retinoblastoma cells to hyperthermia (HT). We examined the effects of BAG3 knockdown on the sensitivity of Y79 and WERI-Rb-1cells to HT (44 °C, 1 h) by evaluating apoptosis and cell proliferation using western blotting, real-time quantitative PCR (qPCR), flow cytometry, and a WST-8 assay kit. Furthermore, we examined the effects of activating nuclear factor-kappa B (NF-κB) and extracellular signal-regulated kinase (ERK) using western blotting and real time qPCR. HT induced considerable apoptosis along with the activation of caspase-3 and chromatin condensation. The sensitivity of Y79 and WERI-Rb-1 cells to HT was significantly enhanced by BAG3 knockdown. Compared to HT alone, the combination of BAG3 knockdown and HT reduced phosphorylation of the inhibitors of kappa B α (IκBα) and p65, a subunit of NF-κB, and degraded IκB kinase γ (IKKγ) during the recovery period after HT. Furthermore, BAG3 knockdown increased the HT-induced phosphorylation of ERK after HT treatment, and the ERK inhibitor U0126 significantly improved the viability of the cells treated with a combination of BAG3 knockdown and HT. The silencing of BAG3 seems to enhance the effects of HT, at least in part, by maintaining HT-induced inactivity of NF-κB and the phosphorylation of ERK. These findings indicate that BAG3 may be a potential molecular target for modifying the outcomes of HT in retinoblastoma.

  19. The Arabidopsis thaliana mutant air1 implicates SOS3 in the regulation of anthocyanins under salt stress

    KAUST Repository

    Van Oosten, Michael James

    2013-08-08

    The accumulation of anthocyanins in plants exposed to salt stress has been largely documented. However, the functional link and regulatory components underlying the biosynthesis of these molecules during exposure to stress are largely unknown. In a screen of second site suppressors of the salt overly sensitive3-1 (sos3-1) mutant, we isolated the anthocyanin-impaired-response-1 (air1) mutant. air1 is unable to accumulate anthocyanins under salt stress, a key phenotype of sos3-1 under high NaCl levels (120 mM). The air1 mutant showed a defect in anthocyanin production in response to salt stress but not to other stresses such as high light, low phosphorous, high temperature or drought stress. This specificity indicated that air1 mutation did not affect anthocyanin biosynthesis but rather its regulation in response to salt stress. Analysis of this mutant revealed a T-DNA insertion at the first exon of an Arabidopsis thaliana gene encoding for a basic region-leucine zipper transcription factor. air1 mutants displayed higher survival rates compared to wild-type in oxidative stress conditions, and presented an altered expression of anthocyanin biosynthetic genes such as F3H, F3′H and LDOX in salt stress conditions. The results presented here indicate that AIR1 is involved in the regulation of various steps of the flavonoid and anthocyanin accumulation pathways and is itself regulated by the salt-stress response signalling machinery. The discovery and characterization of AIR1 opens avenues to dissect the connections between abiotic stress and accumulation of antioxidants in the form of flavonoids and anthocyanins. © 2013 Springer Science+Business Media Dordrecht.

  20. Biodegradable bags for the production of plant seedlings

    OpenAIRE

    Bilck,Ana Paula; Olivato,Juliana Bonametti; Yamashita,Fabio; Souza,José Roberto Pinto de

    2014-01-01

    The production of plant seedlings has traditionally used polyethylene bags, which are thrown out in the soil or burned after transplant because the large amount of organic material attached to the bags makes recycling difficult. Additionally, when a seedling is taken from the bag for transplant, there is the risk of root damage, which compromises the plant’s development. In this study, we developed biodegradable bags to be used in seedling production, and we verify their influence on the deve...

  1. 49 CFR 178.521 - Standards for paper bags.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for paper bags. 178.521 Section 178.521...-bulk Performance-Oriented Packaging Standards § 178.521 Standards for paper bags. (a) The following are identification codes for paper bags: (1) 5M1 for a multi-wall paper bag; and (2) 5M2 for a multi-wall water...

  2. An update on purple urine bag syndrome

    Directory of Open Access Journals (Sweden)

    Hadano Y

    2012-08-01

    Full Text Available Yoshiro Hadano,1 Taro Shimizu,2 Shimon Takada,3 Toshiya Inoue,4 Sumire Sorano51Department of General Internal Medicine and Infectious Diseases, Rakuwakai Otowa Hospital, Yamashina-ku, Kyoto, Japan; 2Rollins School of Public Health, Emory University, Atlanta, GA, USA; 3Department of General Internal Medicine, Osaka City General Hospital, Miyakojima-ku, Osaka, Japan; 4Department of Emergency Medicine, Urasoe General Hospital, Urasoe-city, Okinawa, Japan; 5Kobe University School of Medicine, Kusunokicho, Chuoku, Kobe, JapanAbstract: Purple urine bag syndrome is characterized by the urinary drainage bag turning purple in patients on prolonged urinary catheterization, especially those in the bedridden state. It is associated with bacterial urinary tract infections caused by indigo-producing and indirubin-producing bacteria, usually affects women, and is associated with alkaline urine, constipation, and a high bacterial load in the urine. Almost all patients with purple urine bag syndrome are catheterized due to significant disability, and the urinary pH is 7.0 or more. In general, intensive treatment with antibiotics is not recommended. Purple urine bag syndrome per se almost always appears to be asymptomatic and harmless. However, caution is needed, because some cases have been reported to show progression to severe disease states, so further research into the morbidity and mortality of this infection is warranted.Keywords: purple urine, urinary catheterization, geriatrics, urinary tract infection

  3. Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Kyung-Min Yang

    2017-12-01

    Full Text Available Summary: Triple-negative breast cancer (TNBC is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers. Here, we report a unique role for Bcl-2-associated athanogene 2 (BAG2, which is significantly overexpressed in TNBC, in regulating the dual functions of cathepsin B as either a pro- or anti-oncogenic enzyme. Silencing BAG2 suppresses tumorigenesis and lung metastasis and induces apoptosis by increasing the intracellular mature form of cathepsin B, whereas BAG2 expression induces metastasis by blocking the auto-cleavage processing of pro-cathepsin B via interaction with the propeptide region. BAG2 regulates pro-cathepsin B/annexin II complex formation and facilitates the trafficking of pro-cathespin-B-containing TGN38-positive vesicles toward the cell periphery, leading to the secretion of pro-cathepsin B, which induces metastasis. Collectively, our results uncover BAG2 as a regulator of the oncogenic function of pro-cathepsin B and a potential diagnostic and therapeutic target that may reduce the burden of metastatic breast cancer. : The mechanisms controlling the pro- and anti-oncogenic roles of cathepsin B are unclear. Yang et al. find that BAG2 is a regulator of the dual functions of its client protein, CTSB, facilitating the progression of TNBC. Keywords: BAG2, cathepsin B, TNBC, tumorigenesis, metastasis, breast cancer, TGN38

  4. CA Air Resource Board's Off-Road Diesel Equipment Regulation 2017 DOORS Reporting.

    Energy Technology Data Exchange (ETDEWEB)

    Jadhav, Pradnya [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2018-02-01

    Sandia National Laboratories/CA (SNL/CA) operates 14 diesel vehicles subject to the Off-Road Diesel Equipment Regulation; all the vehicles are classified as low-use vehicles. Annually, SNL/CA must report to the CA Air Resources Board (ARB) the hour-meter readings on our Off-Road Low-Use Diesel Equipment. This is to verify to the CA ARB that our equipment is being operated less than 200 hr/yr and therefore is considered “low-use” and not subject to the strict emissions standards for off-road diesel equipment. The reporting is done using DOORS, the CA ARB’s on-line reporting tool. The hour meter data for CY2017 has already been submitted using DOORS. The final step in the annual reporting process, which needs to be done by DOE, is to submit the Responsible Official Affirmation of Reporting (ROAR), which affirms that the information reported using DOORS is accurate. The ROAR is to be signed by a “Responsible Official” and can be submitted as a hardcopy ROAR or an electronic ROAR (e-ROAR) by March 1st, 2018. CA ARB’s preferred mechanism of ROAR submission is by using the e-ROAR.

  5. Myeloid Heme Oxygenase-1 Regulates the Acute Inflammatory Response to Zymosan in the Mouse Air Pouch

    Directory of Open Access Journals (Sweden)

    Rita Brines

    2018-01-01

    Full Text Available Heme oxygenase-1 (HO-1 is induced by many stimuli to modulate the activation and function of different cell types during innate immune responses. Although HO-1 has shown anti-inflammatory effects in different systems, there are few data on the contribution of myeloid HO-1 and its role in inflammatory processes is not well understood. To address this point, we have used HO-1M-KO mice with myeloid-restricted deletion of HO-1 to specifically investigate its influence on the acute inflammatory response to zymosan in vivo. In the mouse air pouch model, we have shown an exacerbated inflammation in HO-1M-KO mice with increased neutrophil infiltration accompanied by high levels of inflammatory mediators such as interleukin-1β, tumor necrosis factor-α, and prostaglandin E2. The expression of the degradative enzyme matrix metalloproteinase-3 (MMP-3 was also enhanced. In addition, we observed higher levels of serum MMP-3 in HO-1M-KO mice compared with control mice, suggesting the presence of systemic inflammation. Altogether, these findings demonstrate that myeloid HO-1 plays an anti-inflammatory role in the acute response to zymosan in vivo and suggest the interest of this target to regulate inflammatory processes.

  6. 21 CFR 870.3650 - Pacemaker polymeric mesh bag.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Pacemaker polymeric mesh bag. 870.3650 Section 870...) MEDICAL DEVICES CARDIOVASCULAR DEVICES Cardiovascular Prosthetic Devices § 870.3650 Pacemaker polymeric mesh bag. (a) Identification. A pacemaker polymeric mesh bag is an implanted device used to hold a...

  7. 49 CFR 178.519 - Standards for plastic film bags.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for plastic film bags. 178.519 Section... PACKAGINGS Non-bulk Performance-Oriented Packaging Standards § 178.519 Standards for plastic film bags. (a) The identification code for a plastic film bag is 5H4. (b) Construction requirements for plastic film...

  8. 49 CFR 178.518 - Standards for woven plastic bags.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for woven plastic bags. 178.518 Section... PACKAGINGS Non-bulk Performance-Oriented Packaging Standards § 178.518 Standards for woven plastic bags. (a) The following are identification codes for woven plastic bags: (1) 5H1 for an unlined or non-coated...

  9. 49 CFR 178.520 - Standards for textile bags.

    Science.gov (United States)

    2010-10-01

    ..., plastic film bonded to the inner surface of the bag, or one or more inner liners made of paper or plastic... bag, or one or more inner liners made of plastic material or metalized film or foil. (4) Maximum net... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for textile bags. 178.520 Section 178...

  10. On the vacuum baryon number in the chiral bag model

    International Nuclear Information System (INIS)

    Jaroszewicz, T.

    1984-01-01

    We give a rederivation, generalization and interpretation of the result of Goldstone and Jaffe on the vacuum baryon number in the chiral bag model. Our results are based on considering the bag model as a theory of free quarks, massless inside and infinitely massive outside the bag. (orig.)

  11. Determination of H2 Diffusion Rates through Various Closures on TRU Waste Bag-Out Bags

    International Nuclear Information System (INIS)

    Noll, Phillip D. Jr.; Callis, E. Larry; Norman, Kirsten M.

    1999-01-01

    The amount of H 2 diffusion through twist and tape (horse-tail), wire tie, plastic tie, and heat sealed closures on transuranic (TRU) waste bag-out bags has been determined. H 2 diffusion through wire and plastic tie closures on TRU waste bag-out bags has not been previously characterized and, as such, TRU waste drums containing bags with these closures cannot be certified and/or shipped to the Waste Isolation Pilot Plant (WIPP). Since wire ties have been used at Los Alamos National Laboratory (LANL) from 1980 to 1991 and the plastic ties from 1991 to the present, there are currently thousands of waste drums that cannot be shipped to the WIPP site. Repackaging the waste would be prohibitively expensive. Diffusion experiments performed on the above mentioned closures show that the diffusion rates of plastic tie and horse-tail closures are greater than the accepted value presented in the TRU-PACT 11 Safety Analysis Report (SAR). Diffusion rates for wire tie closures are not statistically different from the SAR value. Thus, drums containing bags with these closures can now potentially be certified which would allow for their consequent shipment to WIPP

  12. The Cheshire Cat principle for hybrid bag models

    International Nuclear Information System (INIS)

    Nielsen, H.B.

    1987-05-01

    The Cheshire Cat point of view where the bag in the chiral bag model has no physical significance, but only a notational one is argued for. It is explained how a fermion - in, say, a 1+1 dimensional exact Cheshire Cat model - escapes the bag by means of an anomaly. The possibility to construct sophisticated hybrid bag models is suggested which use the lack of physical significance of the bag to fix the many parameters so as to anyway give hope of a phenomenologically sensible model. (orig.)

  13. Autoregulation of Co-Chaperone BAG3 Gene Transcription

    OpenAIRE

    Gentilella, Antonio; Khalili, Kamel

    2009-01-01

    The Bcl-2-associated athanogene, BAG, protein family through their BAG domain associates with the heat shock protein 70 (HSP-70) and modulates its chaperone activity. One member of this family, BAG3, appears to play an important role in protein homeostasis, as its expression promotes cell survival by preventing polyubiquitination of Hsp-70 client proteins. Expression of BAG3 is enhanced by a variety of stress-inducing agents. Here we describe a role for BAG3 to modulate transcription of its o...

  14. Involvement of JNK and NF-κB pathways in lipopolysaccharide (LPS)-induced BAG3 expression in human monocytic cells.

    Science.gov (United States)

    Wang, Hua-Qin; Meng, Xin; Liu, Bao-Qin; Li, Chao; Gao, Yan-Yan; Niu, Xiao-Fang; Li, Ning; Guan, Yifu; Du, Zhen-Xian

    2012-01-01

    Lipopolysaccharide (LPS) is an outer-membrane glycolipid component of Gram-negative bacteria known for its fervent ability to activate monocytic cells and for its potent proinflammatory capabilities. Bcl-2-associated athanogene 3 (BAG3) is a survival protein that has been shown to be stimulated during cell response to stressful conditions, such as exposure to high temperature, heavy metals, proteasome inhibition, and human immunodeficiency virus 1 (HIV-1) infection. In addition, BAG3 regulates replication of Varicella-Zoster Virus (VZV) and Herpes Simplex Virus (HSV) replication, suggesting that BAG3 could participate in the host response to infection. In the current study, we found that LPS increased the expression of BAG3 in a dose- and time-dependent manner. Actinomycin D completely blocked the LPS-induced BAG3 accumulation, as well as LPS activated the proximal promoter of BAG3 gene, supported that the induction by LPS occurred at the level of gene transcription. LPS-induced BAG3 expression was blocked by JNK or NF-κB inhibition, suggesting that JNK and NF-κB pathways participated in BAG3 induction by LPS. In addition, we also found that induction of BAG3 was implicated in monocytic cell adhesion to extracellular matrix induced by LPS. Overall, the data support that BAG3 is induced by LPS via JNK and NF-κB-dependent signals, and involved in monocytic cell-extracellular matrix interaction, suggesting that BAG3 may have a role in the host response to LPS stimulation. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. Clean/alternative fueled fleet programs - 1990 Amendments to the Clean Air Act, the Colorado Air Pollution Prevention and Control Act, and Denver City and County regulations

    International Nuclear Information System (INIS)

    Bowles, S.L.; Manderino, L.A.

    1993-01-01

    Despite substantial regulations for nearly two decades, attainment of this ambient standards for ozone and carbon monoxide (CO) remain difficult goals to achieve, Even with of ozone precursors and CO. The 1990 Amendments to the Clean Air Act (CAA90) prescribe further reductions of mobile source emissions. One such reduction strategy is using clean fuels, such as methanol, ethanol, or other alcohols (in blends of 85 percent or more alcohol with gasoline or other fuel), reformulated gasoline or diesel, natural gas, liquified petroleum gas, hydrogen, or electricity. There are regulatory measures involving special fuels which will be required in areas heavily polluted with ozone and CO. The state of Colorado recently passed the 1992 Air Pollution Prevention and Control Act which included provisions for the use of alternative fuels which will be implemented in 1994. In addition to adhering to the Colorado state regulations, the city and county of Denver also have regulations pertaining to the use of alternative fuels in fleets of 10 or more vehicles. Denver's program began in 1992. This paper will address the issue of fleet conversion and its impact on industry in Colorado, and Denver in particular

  16. Platelet storage in Fresenius/NPBI polyolefin and BTHC-PVC bags: a direct comparison.

    Science.gov (United States)

    Hornsey, V S; McColl, K; Drummond, O; Macgregor, I R; Prowse, C V

    2008-08-01

    New platelet storage systems, such as changes in the plastic of the storage bags, require validation. In this study, pooled buffy coat platelets stored in Fresenius/NPBI polyolefin bags were compared with those stored in Fresenius/NPBI butyryl-trihexyl citrate (BTHC) plasticized polyvinyl chloride (PVC). The CompoSelect thrombocyte polishing filter system (1000 mL polyolefin bag) and the CompoStop F730 system (1300 mL BTHC-PVC bag) were used to prepare paired, plasma-suspended, buffy coat platelet concentrates. Samples were taken up to day 7 for in vitro analysis. In a separate experiment, 12 units were prepared using the CompoStop F730 system and samples taken after leucofiltration for FXIIa assay. By day 7, platelet concentrates stored in BTHC-PVC demonstrated significantly higher pH levels (7.32 +/- 0.05 vs. 7.26 +/- 0.05) and a greater degree of cell lysis as shown by increased lactate dehydrogenase levels (497 +/- 107 vs. 392 +/- 81 U L(-1)). The supernatants contained higher concentrations of soluble P-selectin and the chemokine 'regulated on activation, normal T-cell expressed and presumably secreted', which are released from the alpha-granules during activation. The ATP concentrations were significantly lower in BTHC-PVC. Platelet counts, mean platelet volume and hypotonic shock response were similar for both bags. FXIIa antigen concentrations were 0.6 +/- 0.2 ng mL(-1) indicating that activation of the contact factor pathway had not occurred. Although the CompoStop F730 leucoreduction filter did not activate the contact system, platelets stored in 100% plasma in BTHC-PVC bags demonstrated different in vitro characteristics from those stored in polyolefin. Further work is required to demonstrate whether these differences will affect in vivo recovery and survival.

  17. The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

    Directory of Open Access Journals (Sweden)

    Elisabeth Stürner

    2017-06-01

    Full Text Available In neurons, but also in all other cells the complex proteostasis network is monitored and tightly regulated by the cellular protein quality control (PQC system. Beyond folding of newly synthesized polypeptides and their refolding upon misfolding the PQC also manages the disposal of aberrant proteins either by the ubiquitin-proteasome machinery or by the autophagic-lysosomal system. Aggregated proteins are primarily degraded by a process termed selective macroautophagy (or aggrephagy. One such recently discovered selective macroautophagy pathway is mediated by the multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3. Under acute stress and during cellular aging, BAG3 in concert with the molecular chaperones HSP70 and HSPB8 as well as the ubiquitin receptor p62/SQSTM1 specifically targets aggregation-prone proteins to autophagic degradation. Thereby, BAG3-mediated selective macroautophagy represents a pivotal adaptive safeguarding and emergency system of the PQC which is activated under pathophysiological conditions to ensure cellular proteostasis. Interestingly, BAG3-mediated selective macroautophagy is also involved in the clearance of aggregated proteins associated with age-related neurodegenerative disorders, like Alzheimer’s disease (tau-protein, Huntington’s disease (mutated huntingtin/polyQ proteins, and amyotrophic lateral sclerosis (mutated SOD1. In addition, based on its initial description BAG3 is an anti-apoptotic protein that plays a decisive role in other widespread diseases, including cancer and myopathies. Therefore, in the search for novel therapeutic intervention avenues in neurodegeneration, myopathies and cancer BAG3 is a promising candidate.

  18. Impact of a new gasoline benzene regulation on ambient air pollutants in Anchorage, Alaska

    Science.gov (United States)

    Yano, Yuriko; Morris, Stephen S.; Salerno, Christopher; Schlapia, Anne M.; Stichick, Mathew

    2016-05-01

    The purpose of this study was to quantify the impact of a new U.S. Environmental Protection Agency (EPA) standard that limits the amount of benzene allowed in gasoline on ambient benzene concentrations. This new standard, together with two companion regulations that limit cold-temperature automotive emissions and the permeability of portable fuel containers, was expected to lower the levels of ambient benzene and other volatile organic compounds (VOCs) nationwide. In this study the impact of the gasoline benzene standard was evaluated in Anchorage, Alaska in a two-phase ambient air monitoring study conducted before and after the new gasoline standard was implemented. Gasoline sold by Anchorage retailers was also evaluated in each phase to determine the content of benzene and other gasoline components. The average benzene content in Anchorage gasoline was reduced by 70%, from 5.05% (w/w) to 1.53% (w/w) following the implementation of the standard. The annual mean ambient benzene concentration fell by 51%, from 0.99 ppbv in Phase 1 to 0.49 ppbv in Phase 2. Analysis suggests the change in gasoline benzene content alone reduced benzene emissions by 46%. The changes in toluene, ethylbenzene, and xylene content in gasoline between Phase 1 and 2 were relatively small and the differences in the mean ambient concentrations of these compounds between phases were modest. Our results suggest that cold winter communities in high latitude and mountainous regions may benefit more from the gasoline benzene standard because of high benzene emissions resulting from vehicle cold start and a tendency to develop atmospheric stagnation conditions in the winter.

  19. Air quality assessment of carbon monoxide, nitrogen dioxide and ...

    African Journals Online (AJOL)

    Tumwitike

    Technology ... Biochemical Sciences Department, University of Malawi, Private Bag 303, Blantyre 3 ... urban air quality monitoring in Blantyre and all urban areas in Malawi. ... Key words: Air pollutants, principal component analysis, developing ...

  20. Contamination of nebulisers and surrounding air at the bedside of ...

    African Journals Online (AJOL)

    An air sampler was used to collect air samples from the surrounding bedside environment. .... individualised resealable plastic bags and stored upside down in a cooler .... conventional and mesh technology nebulisers used at home by adults.

  1. An electronic flight bag for NextGen avionics

    Science.gov (United States)

    Zelazo, D. Eyton

    2012-06-01

    The introduction of the Next Generation Air Transportation System (NextGen) initiative by the Federal Aviation Administration (FAA) will impose new requirements for cockpit avionics. A similar program is also taking place in Europe by the European Organisation for the Safety of Air Navigation (Eurocontrol) called the Single European Sky Air Traffic Management Research (SESAR) initiative. NextGen will require aircraft to utilize Automatic Dependent Surveillance-Broadcast (ADS-B) in/out technology, requiring substantial changes to existing cockpit display systems. There are two ways that aircraft operators can upgrade their aircraft in order to utilize ADS-B technology. The first is to replace existing primary flight displays with new displays that are ADS-B compatible. The second, less costly approach is to install an advanced Class 3 Electronic Flight Bag (EFB) system. The installation of Class 3 EFBs in the cockpit will allow aircraft operators to utilize ADS-B technology in a lesser amount of time with a decreased cost of implementation and will provide additional benefits to the operator. This paper describes a Class 3 EFB, the NexisTM Flight-Intelligence System, which has been designed to allow users a direct interface with NextGen avionics sensors while additionally providing the pilot with all the necessary information to meet NextGen requirements.

  2. Inflatable bag with sealing and protection layer

    International Nuclear Information System (INIS)

    Kocourek, L.; Dohnal, M.; Klinga, J.; Matal, O.; Holy, F.

    1989-01-01

    The inflatable bag consists of a textile casing in which a cylindrical pvc tyre with concave bottoms is inserted and glued to the casing. A sealing protective layer is provided on the outer periphery of the cylindrical part of the tyre. A tyre valve with flange and fixing ears and also a relief valve are provided in the concave bottom. The casing material, such as a layer of 0.5 to 5 mm silicone rubber bands is suitable for use in contact with austenitic materials. The bag completely seals spaces such as the mouths of steam generator tubes or collector branches in a nuclear power plant. Decontamination can easily be achieved by rinsing the surface with common means. (J.B.). 2 figs

  3. SIMULATION OF A MATHEMATICAL MODEL FOR THE TEMPERATURE PROFILE IN A SILO BAG FOR BEAN

    Directory of Open Access Journals (Sweden)

    M. R. Hauth

    2015-02-01

    Full Text Available The problems encountered with storage of agricultural products has warranted studies related to finding alternative methods of grain storage, thereby avoiding unnecessary losses. Stored grain deteriorates quickly at high temperatures. The moisture content of the grain influences the respiratory process; therefore, when at the recommended humidity of between 11 and 13%, this rate remains low, it prolongs maintenance of the product quality. The silo bag being airtight enables the grain mass to consume the entire internal O2 purse within it, and in that low or absent oxygen environment the grain mass saturates the CO2 atmosphere, inhibiting the multiplication of insects and fungi, thus providing a controlled environment. This study aims at simulating, using Computational Fluid Dynamics (CFD, the time it would take for the entire grain mass contained in a silo bag to reach thermal equilibrium with the environment and analyzes the feasibility of the technique employed here. The simulations were performed based on the data of the average air temperature in the region at each harvest time and the average storage temperature of the bean mass (60°C. The results obtained from the simulations reveal that after one month of silo storage the entire bag remains in thermal stabilization, and four months later when it hits the entire mass, all the beans are in thermal equilibrium. Therefore, maintaining stable temperature and humidity within the recommended silo bag preserves the grain quality well.

  4. An analytical hierarchy process-based study on the factors affecting legislation on plastic bags in the USA.

    Science.gov (United States)

    Li, Zhongguo; Zhao, Fu

    2017-08-01

    Annually, a large number of used plastic shopping bags are released into the environment, posing significant threats to public health and wildlife. Owing to these concerns, many local, regional, and national governments around the world have passed legislation to ban or restrict the use of plastic shopping bags. However, in the USA there are only 18 states that have approved plastic bag bans/fees, and even within these states these regulations do not cover all cities or counties. There are many factors that could affect the development and implementation of these regulations. This article employs an analytical hierarchy process to analyse the factors that could impact the enactment of plastic bag regulations. Five impact factors are identified based on statistical data, that is, geographical location, interest of industry achievable, cost of living, level of economic development, and educational level of population. The weights of the five impact factors are determined and it is found that the possibility of banning or restricting plastic bags in general follows a certain pattern among all states.

  5. Are there multiquark bags in nuclei

    International Nuclear Information System (INIS)

    Kondratyuk, L.A.; Scmatkov, M.Zh.

    1983-01-01

    Arguments are presented favouring the idea that multiquark bags do eXist in nuclei. Such hypothesis makes possible to reveal the relationship among three different scopes of phenomena: deep inelastic scattering of leptons by nUclei, large q 2 (where q 2 is a square of momentum transfer) behaviour of the form factors of light nuclei and yield of cumulative proton.s

  6. Chiral bags, skyrmions and quarks in nuclei

    International Nuclear Information System (INIS)

    Rho, M.

    1984-09-01

    Recent developments on an intriguing connection between the quark-bag description of the baryons (nucleons in particular) and the Skyrmion model are discussed in terms of the constraints coming from chiral anomalies. Topics treated are the leaking baryon charge, axial charge and energy density; the role of chiral anomalies; the role of Skyrme's quartic term and the connection to the meson degrees of freedom; and finally some qualitative implications in nuclei. The presentation is purposely descriptive and intuitive instead of mathematically precise

  7. Urine Bag as a Modern Day Matula

    OpenAIRE

    Viswanathan, Stalin

    2013-01-01

    Since time immemorial uroscopic analysis has been a staple of diagnostic medicine. It received prominence during the middle ages with the introduction of the matula. Urinary discoloration is generally due to changes in urochrome concentration associated with the presence of other endogenous or exogenous pigments. Observation of urine colors has received less attention due to the advances made in urinalysis. A gamut of urine colors can be seen in urine bags of hospitalized patients that may gi...

  8. BAG3 myofibrillar myopathy presenting with cardiomyopathy.

    Science.gov (United States)

    Konersman, Chamindra G; Bordini, Brett J; Scharer, Gunter; Lawlor, Michael W; Zangwill, Steven; Southern, James F; Amos, Louella; Geddes, Gabrielle C; Kliegman, Robert; Collins, Michael P

    2015-05-01

    Myofibrillar myopathies (MFMs) are a heterogeneous group of neuromuscular disorders distinguished by the pathological hallmark of myofibrillar dissolution. Most patients present in adulthood, but mutations in several genes including BCL2-associated athanogene 3 (BAG3) cause predominantly childhood-onset disease. BAG3-related MFM is particularly severe, featuring weakness, cardiomyopathy, neuropathy, and early lethality. While prior cases reported either neuromuscular weakness or concurrent weakness and cardiomyopathy at onset, we describe the first case in which cardiomyopathy and cardiac transplantation (age eight) preceded neuromuscular weakness by several years (age 12). The phenotype comprised distal weakness and severe sensorimotor neuropathy. Nerve biopsy was primarily axonal with secondary demyelinating/remyelinating changes without "giant axons." Muscle biopsy showed extensive neuropathic changes that made myopathic changes difficult to interpret. Similar to previous cases, a p.Pro209Leu mutation in exon 3 of BAG3 was found. This case underlines the importance of evaluating for MFMs in patients with combined neuromuscular weakness and cardiomyopathy. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Teaching case studies on the regulation of motor vehicle air pollution in China.

    Science.gov (United States)

    2009-12-23

    Motor vehicle air pollution is a critical component of China's severe air quality problem and has the potential to become an even greater issue in the years to come. On this project, the principal investigator and research staff are developing Harvar...

  10. 78 FR 46552 - Approval and Promulgation of Air Quality Implementation Plans; Massachusetts; Regulations...

    Science.gov (United States)

    2013-08-01

    ... by the Commonwealth of Massachusetts. These are revisions to existing air pollution control... facilitate interpretation and understanding, and enhance enforceability, of the state's air pollution control... emission limits, was added to the following sections: of 310 CMR 7.18: (21), Surface Coating of Plastic...

  11. Ventilatory and Cardiovascular Regulation in the Air-Breathing Fish Pangasianodon Hypophthalmus

    DEFF Research Database (Denmark)

    Thomsen, Mikkel; Wang, Tobias; Bayley, Mark

    The air-breathing fish Pangasianodon hypophthalmus is abundant in the Mekong river system where it is also intensively cultured. In contrast to most other air-breathing fishes it has well developed gills as well as a highly traberculated swim bladder with a large surface area used for air-breathing...... systems provide information on when gill ventilation is insufficient for oxygen uptake and hence initiate air-breathing. Here we investigate the ventilatory and cardiovascular responses to changes in either in the external media or internally in the blood in resting fish. We found ventilation in P....... Its native waters have been shown to be periodically strongly hypoxic and hypercarbic, forcing P. hypophthalmus to switch from exclusively branchial ventilation to air-breathing to maintain its aerobic metabolism. This ability to switch respiratory media demands that the oxygen- and CO¬2 sensory...

  12. Ca2+-induced uncoupling of Aplysia bag cell neurons.

    Science.gov (United States)

    Dargaei, Zahra; Standage, Dominic; Groten, Christopher J; Blohm, Gunnar; Magoski, Neil S

    2015-02-01

    Electrical transmission is a dynamically regulated form of communication and key to synchronizing neuronal activity. The bag cell neurons of Aplysia are a group of electrically coupled neuroendocrine cells that initiate ovulation by secreting egg-laying hormone during a prolonged period of synchronous firing called the afterdischarge. Accompanying the afterdischarge is an increase in intracellular Ca2+ and the activation of protein kinase C (PKC). We used whole cell recording from paired cultured bag cell neurons to demonstrate that electrical coupling is regulated by both Ca2+ and PKC. Elevating Ca2+ with a train of voltage steps, mimicking the onset of the afterdischarge, decreased junctional current for up to 30 min. Inhibition was most effective when Ca2+ entry occurred in both neurons. Depletion of Ca2+ from the mitochondria, but not the endoplasmic reticulum, also attenuated the electrical synapse. Buffering Ca2+ with high intracellular EGTA or inhibiting calmodulin kinase prevented uncoupling. Furthermore, activating PKC produced a small but clear decrease in junctional current, while triggering both Ca2+ influx and PKC inhibited the electrical synapse to a greater extent than Ca2+ alone. Finally, the amplitude and time course of the postsynaptic electrotonic response were attenuated after Ca2+ influx. A mathematical model of electrically connected neurons showed that excessive coupling reduced recruitment of the cells to fire, whereas less coupling led to spiking of essentially all neurons. Thus a decrease in electrical synapses could promote the afterdischarge by ensuring prompt recovery of electrotonic potentials or making the neurons more responsive to current spreading through the network. Copyright © 2015 the American Physiological Society.

  13. Bagworm bags as portable armour against invertebrate predators

    Directory of Open Access Journals (Sweden)

    Shinji Sugiura

    2016-02-01

    Full Text Available Some animals have evolved the use of environmental materials as “portable armour” against natural enemies. Portable bags that bagworm larvae (Lepidoptera: Psychidae construct using their own silk and plant parts are generally believed to play an important role as a physical barrier against natural enemies. However, no experimental studies have tested the importance of bags as portable armour against predators. To clarify the defensive function, I studied the bagworm Eumeta minuscula and a potential predator Calosoma maximoviczi (Coleoptera: Carabidae. Under laboratory conditions, all bagworm larvae were attacked by carabid adults, but successfully defended themselves against the predators’ mandibles using their own bags. The portable bags, which are composed mainly of host plant twigs, may function as a physical barrier against predator mandibles. To test this hypothesis, I removed the twig bags and replaced some with herb leaf bags; all bag-removed larvae were easily caught and predated by carabids, while all bag-replaced larvae could successfully defend themselves against carabid attacks. Therefore, various types of portable bags can protect bagworm larvae from carabid attacks. This is the first study to test the defensive function of bagworm portable bags against invertebrate predators.

  14. Biodegradable bags for the production of plant seedlings

    Directory of Open Access Journals (Sweden)

    Ana Paula Bilck

    2014-10-01

    Full Text Available The production of plant seedlings has traditionally used polyethylene bags, which are thrown out in the soil or burned after transplant because the large amount of organic material attached to the bags makes recycling difficult. Additionally, when a seedling is taken from the bag for transplant, there is the risk of root damage, which compromises the plant’s development. In this study, we developed biodegradable bags to be used in seedling production, and we verify their influence on the development of Brazilian ginseng (Pfaffia glomerata (Spreng Pedersen, when the plant is planted without being removed from the bag. Both black and white biodegradable bags remained intact throughout the seedling production period (60 days. After being transplanted into containers (240 days, they were completely biodegraded, and there was no significant difference between the dry mass of these plants and that of plants that were transplanted without the bags. The plants that were cultivated without being removed from the polyethylene bags had root development difficulties, and the wrapping showed no signs of degradation. The use of biodegradable films is an alternative for the production of bags for seedlings, as these can then be transplanted directly into the soil without removing the bag, reducing the risk of damage to the roots during the moment of transplant.

  15. Bagworm bags as portable armour against invertebrate predators.

    Science.gov (United States)

    Sugiura, Shinji

    2016-01-01

    Some animals have evolved the use of environmental materials as "portable armour" against natural enemies. Portable bags that bagworm larvae (Lepidoptera: Psychidae) construct using their own silk and plant parts are generally believed to play an important role as a physical barrier against natural enemies. However, no experimental studies have tested the importance of bags as portable armour against predators. To clarify the defensive function, I studied the bagworm Eumeta minuscula and a potential predator Calosoma maximoviczi (Coleoptera: Carabidae). Under laboratory conditions, all bagworm larvae were attacked by carabid adults, but successfully defended themselves against the predators' mandibles using their own bags. The portable bags, which are composed mainly of host plant twigs, may function as a physical barrier against predator mandibles. To test this hypothesis, I removed the twig bags and replaced some with herb leaf bags; all bag-removed larvae were easily caught and predated by carabids, while all bag-replaced larvae could successfully defend themselves against carabid attacks. Therefore, various types of portable bags can protect bagworm larvae from carabid attacks. This is the first study to test the defensive function of bagworm portable bags against invertebrate predators.

  16. Assessment and remediation of odor emissions from a complex industrial facility (Ambient air odor regulations in Canada and the United States)

    International Nuclear Information System (INIS)

    Boose, T.; Reusing, G.

    2002-01-01

    This paper describes the findings of a review and presents examples of ambient air odor regulations in Canada and the United States. State and provincial odor regulations were reviewed and other metropolitan cities or counties (regions) that have separate odor regulations were also included. The key topics addressed in this paper include an assessment of the methods used for odor regulation and the methods used to evaluate the odor impact to determine compliance with the regulation. Three types of ambient air odor regulations were identified: 1. 28 States, Provinces and regions (jurisdictions) have specific odor regulations. These regulations generally define what constitutes an odor impact and typically provide requirements for remedial measures; 2. 25 jurisdictions regulate odors by a general prohibition regulation. These regulations define odor in ambient air as a condition of air pollution, nuisance or objectionable odor that would typically prevent persons from the enjoyment of life and property; and 3. 13 jurisdictions do not have specific or general prohibition regulations regarding odors. For the jurisdictions that have specific or general prohibition odor regulations, there are a number of different techniques used to define what constitutes an odor impact. Odor impacts are typically defined in a regulation by one (or more) of the following techniques: dilution to threshold, or odor unit limit; determination of odor emission rates; odor concentration limits for selected chemicals (ppm); comparison with the n-butanol intensity scale (1 to 8); and investigation by an agency investigator. Compliance with odor regulations is typically determined using one (or more) of the following field methods: odor stack testing and dispersion modelling; odor panel analysis of stack or ambient air samples; chemical monitoring (ppm); odor school certified / agency investigator; and scentometer. (author)

  17. Does regulation stimulate productivity? The effect of air quality policies on the efficiency of US power plants

    International Nuclear Information System (INIS)

    Fleishman, Rachel; Alexander, Rob; Bretschneider, Stuart; Popp, David

    2009-01-01

    This research examines the effect of air quality regulations on the productivity of US power plants based on both economic and environmental outputs. Using data envelopment analysis (DEA) to estimate an efficiency measure incorporating both economic and environmental outcomes, we look at changes in efficiency in US power plants over an eleven-year time period (1994-2004) during which several different regulations were implemented for the control of nitrogen oxides (NO x ) and sulfur dioxide (SO 2 ). The paper then models how estimated efficiency behaves over time as a function of regulatory changes. Findings suggest mixed effects of regulations on power plant efficiency when pollution abatement and electricity generation are both included as outputs.

  18. Stability of sodium bicarbonate solutions in polyolefin bags.

    Science.gov (United States)

    Wear, Jennifer; McPherson, Timothy B; Kolling, William M

    2010-06-15

    The stability of sodium bicarbonate solutions in sterile water for injection or 5% dextrose injection stored at 21-24 degrees C or 2-4 degrees C was evaluated. Sodium bicarbonate injection was obtained in 50-mL vials of 8.4% (1 meq/mL). A total of 50, 100, or 150 meq of sodium bicarbonate was added to each 1-L polyolefin bag of either sterile water for injection or 5% dextrose injection. All solutions were prepared in a laminar-airflow hood using aseptic technique. Bags were punctured once to remove headspace air and once for the addition of each 50 meq of sodium bicarbonate. Six replicates of each test solution were prepared. The solutions were stored at 21-24 degrees C and 2-4 degrees C. Control solutions (50 and 150 meq) were similarly prepared in triplicate. Control solutions were sparged with either nitrogen gas or oxygen gas before storage. Sodium bicarbonate stability was assessed by measuring solution pH. Bicarbonate content was measured utilizing titration. Both pH and bicarbonate concentrations were measured immediately upon preparation and on days 3, 5, and 7 for both test and control solutions. All 95% confidence interval values for sample solution pH remained within 7.0-8.5 for seven days at 2-4 degrees C. Sodium bicarbonate solutions of 50, 100, and 150 meq in sterile water for injection or 5% dextrose injection were stable for up to seven days when refrigerated. The 50-meq solution was stable for up to 48 hours when stored at room temperature, and the 100- and 150-meq solutions were stable for up to 30 hours when stored at room temperature.

  19. [Preparation and application of cooling bag for heat stroke in wild field].

    Science.gov (United States)

    Li, Hailing; Lu, Qing; Wang, Hongping; Li, Lujia

    2017-05-01

    Cooling bag for heat stroke in wild field was invented in order to fulfill rapid cooling for heat stroke in field environment. The cooling bag is composed of the hood, the body cover (which is made up of the anterior portion, the linking, and the posterior portion), the fixed straps, the handles. The length is 200 cm, the regulative width is 60-70 cm, the folding volume is 26 cm × 20 cm × 9 cm, and the weight is 1.4 kg. There are a number of pockets for the cold sources in the hood and the body cover. Fixed straps are set in the upper, middle and lower of the bag. The handles are set in the hood and the body covers. Usage: put the activated cold sources in the pockets, then put off the patient's clothes, stretch his/her arms into the linking, zipper up and wrapped up by the fixed straps; the amount of cold sources can be adjusted or changed according to the temperature. The patient's temperature, blood pressure, intravenous infusion can be monitored during the cooling course. The handles in the hood and the body cover allow the patient to be easily moved and be transferred in rescue. The cooling bag for heat stroke in field has good cooling effect, and are reusable and easy to be carried, operate, monitor and move, with low cost, which make it popularization and application.

  20. Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags.

    Science.gov (United States)

    Buckley, K; Atkins, C G; Chen, D; Schulze, H G; Devine, D V; Blades, M W; Turner, R F B

    2016-03-07

    After being separated from (donated) whole blood, red blood cells are suspended in specially formulated additive solutions and stored (at 4 °C) in polyvinyl chloride (PVC) blood-bags until they are needed for transfusion. With time, the prepared red cell concentrate (RCC) is known to undergo biochemical changes that lower effectiveness of the transfusion, and thus regulations are in place that limit the storage period to 42 days. At present, RCC is not subjected to analytical testing prior to transfusion. In this study, we use Spatially Offset Raman Spectroscopy (SORS) to probe, non-invasively, the biochemistry of RCC inside sealed blood-bags. The retrieved spectra compare well with conventional Raman spectra (of sampled aliquots) and are dominated by features associated with hemoglobin. In addition to the analytical demonstration that SORS can be used to retrieve RCC spectra from standard clinical blood-bags without breaking the sterility of the system, the data reveal interesting detail about the oxygenation-state of the stored cells themselves, namely that some blood-bags unexpectedly contain measurable amounts of deoxygenated hemoglobin after weeks of storage. The demonstration that chemical information can be obtained non-invasively using spectroscopy will enable new studies of RCC degeneration, and points the way to a Raman-based instrument for quality-control in a blood-bank or hospital setting.

  1. Role of blood bag temperature indicators in maintaining patent temperature of the returned unused blood bags in blood bank.

    Science.gov (United States)

    Nurasyikin, Y; Leong, C F; Fadhlullah, T M; Hafiz, W M; Nadiah, Z; Atieqah, A N; Ling, T J; Das, S

    2011-01-01

    The main objective of the present study was to evaluate the temperature chain of red blood cells (RBC) returned unused blood bags using blood temperature indicator and ascertain the factors like transportation time, type, size of coolant box and number of bags per box. A total of 250 blood bags with the indicator were observed for the temperature changes with other factors like transportation time, type and size of coolant box and number of bags per box. The recordings were performed at several checkpoints located between the blood bank and the wards. Out of the 250 bags, 74 (29.6%) showed colour changes in which 64 (86.3%) were returned unused (RU) blood bags. The transportation time for these 74 bags was 818.3 ± 941.643 min, significantly higher than bags without colour changes, (p=0.02). Interestingly, 71.4% of the colour changes occurred within the ward. The 7 litre coolant box with an average of 1-5 blood bags per box had a statistically significant higher percentage of colour change with 59.2% compared to the 5 litre coolant box (p=0.05). This study showed that the temperature chain of blood bags was often not well maintained. These results could be mainly due to the non-adherence to the standard operating procedure (SOP) of blood transfusion and the usage of non-standardized coolant boxes.

  2. 75 FR 3423 - Outer Continental Shelf Air Regulations Consistency Update for Alaska

    Science.gov (United States)

    2010-01-21

    ... response, using the definition of burden provided in 44 U.S.C. 3502(2). List of Subjects in 40 CFR Part 55 Environmental protection, Administrative practice and procedures, Air pollution control, Hydrocarbons...

  3. Speed uncertainty and speed regulation in conflict detection and resolution in Air Traffic Control

    OpenAIRE

    Archambault , Nicolas

    2004-01-01

    International audience; With the predicted increase of air traffic volume, new air traffic management models are under investigation in order to increase airspace capacity and keep low delays while maintaining transportation safety standards. One of the tasks implied is to solve conflicts, i.e. maintain a sufficient separation between aircraft. Conflict resolution relies on conflict detection ; indeed predicting aircraft trajectories within a time window allows to detect the conflicts and app...

  4. A hand in the bag; La main dans le sac

    Energy Technology Data Exchange (ETDEWEB)

    Dube, C.

    2009-10-15

    Many retailers have abandoned the plastic bag for seemingly more environmentally friendly biodegradable bags. However, the solution may be worse than the problem. Biodegradable plastic bags are essentially made of the same polyethylene that is used in regular plastic bags. The only difference is that oxo-biodegradable bags have an additive such as iron or manganese that enables them to decompose in 12 to 24 months. The plastic decomposes quickly when exposed to ultraviolet rays or stress. Although the bags have been touted to be recyclable, they are not. This article presented an example of how a park bench made of recycled materials began to deteriorate after only a few weeks outside. The additive therefore renders the plastics ineffectual for use in recycled plastic products. The article also emphasized that contrary to popular belief, the role of landfills is not to accelerate decomposition, but limit it in order to prevent emissions of greenhouse gases. 1 fig.

  5. Knockdown of BAG3 induces epithelial–mesenchymal transition in thyroid cancer cells through ZEB1 activation

    Science.gov (United States)

    Meng, X; Kong, D-H; Li, N; Zong, Z-H; Liu, B-Q; Du, Z-X; Guan, Y; Cao, L; Wang, H-Q

    2014-01-01

    The process by which epithelial features are lost in favor of a mesenchymal phenotype is referred to as epithelial–mesenchymal transition (EMT). Most carcinomas use this mechanism to evade into neighboring tissues. Reduction or a loss of E-cadherin expression is a well-established hallmark of EMT. As a potent suppressor of E-cadherin, transcription factor ZEB1 is one of the key inducers of EMT, whose expression promotes tumorigenesis and metastasis of carcinomas. Bcl-2-associated athanogene 3 (BAG3) affects multifaceted cellular functions, including proliferation, apoptosis, cell adhesion and invasion, viral infection, and autophagy. Recently, we have reported a novel role of BAG3 implicated in EMT, while the mechanisms are poorly elucidated. The current study demonstrated that knockdown of BAG3 induced EMT, and increased cell migratory and invasiveness in thyroid cancer cells via transcriptional activation of ZEB1. We also found that BAG3 knockdown led to nuclear accumulation of β-catenin, which was responsible for the transcriptional activation of ZEB1. These results indicate BAG3 as a regulator of ZEB1 expression in EMT and as a regulator of metastasis in thyroid cancer cells, providing potential targets to prevent and/or treat thyroid cancer cell invasion and metastasis. PMID:24577090

  6. Knockdown of BAG3 induces epithelial-mesenchymal transition in thyroid cancer cells through ZEB1 activation.

    Science.gov (United States)

    Meng, X; Kong, D-H; Li, N; Zong, Z-H; Liu, B-Q; Du, Z-X; Guan, Y; Cao, L; Wang, H-Q

    2014-02-27

    The process by which epithelial features are lost in favor of a mesenchymal phenotype is referred to as epithelial-mesenchymal transition (EMT). Most carcinomas use this mechanism to evade into neighboring tissues. Reduction or a loss of E-cadherin expression is a well-established hallmark of EMT. As a potent suppressor of E-cadherin, transcription factor ZEB1 is one of the key inducers of EMT, whose expression promotes tumorigenesis and metastasis of carcinomas. Bcl-2-associated athanogene 3 (BAG3) affects multifaceted cellular functions, including proliferation, apoptosis, cell adhesion and invasion, viral infection, and autophagy. Recently, we have reported a novel role of BAG3 implicated in EMT, while the mechanisms are poorly elucidated. The current study demonstrated that knockdown of BAG3 induced EMT, and increased cell migratory and invasiveness in thyroid cancer cells via transcriptional activation of ZEB1. We also found that BAG3 knockdown led to nuclear accumulation of β-catenin, which was responsible for the transcriptional activation of ZEB1. These results indicate BAG3 as a regulator of ZEB1 expression in EMT and as a regulator of metastasis in thyroid cancer cells, providing potential targets to prevent and/or treat thyroid cancer cell invasion and metastasis.

  7. Silencing of BAG3 promotes the sensitivity of ovarian cancer cells to cisplatin via inhibition of autophagy.

    Science.gov (United States)

    Qiu, Shuang; Sun, Liang; Jin, Ye; An, Qi; Weng, Changjiang; Zheng, Jianhua

    2017-07-01

    Ovarian cancer is the most lethal disease among all gynecological malignancies. Interval cytoreductive surgery and cisplatin‑based chemotherapy are the recommended therapeutic strategies. However, acquired resistance to cisplatin remains a big challenge for the overall survival and prognosis in ovarian cancer. Complicated molecular mechanisms are involved in the process. At present, increasing evidence indicates that autophagy plays an important role in the prosurvival and resistance against chemotherapy. In the present study, as a novel autophagy regulator, BCL2‑associated athanogene 3 (BAG3) was investigated to study its role in cisplatin sensitivity in epithelial ovarian cancer. However, whether BAG3 participates in cisplatin sensitivity by inducing autophagy and the underlying mechanism in ovarian cancer cells remain to be clarified. Through the use of quantitative real-time PCR, western blot analysis, CCK-8 and immunofluorescence assays our data revealed that cisplatin-induced autophagy protected ovarian cancer cells from the toxicity of the drug and that this process was regulated by BAG3. Silencing of BAG3 increased cisplatin-induced apoptosis. The results also revealed BAG3 as a potential therapeutic target which enhanced the efficacy of cisplatin in ovarian cancer.

  8. Properties of the cloudy bag in nuclear matter

    International Nuclear Information System (INIS)

    Bunatyan, G.G.

    1986-01-01

    Because of the pion mode softening, the pion field of the clody bag in the nuclear matter increases if the nuclear density increases. This causes in its turn the decreasing of the bag size and at a sufficiently large density of the nuclear matter lead to absolute instability of the cloudy bag-nucleon, which means the transition of the nuclear matter in another nonnucleon phase

  9. Hybridizing the Skyrmion with an Anti-de-Sitter bag

    International Nuclear Information System (INIS)

    Rosu, H.

    1992-02-01

    We discuss a phenomenological model of the nucleon in which a small Anti-de-Sitter bag is placed into the Skyrmion configuration. Such a bag has a timelike boundary and allows naturally the Cheshire Cat Principle. Very important in this model is the membrane of the bag, the 3-dimensional manifold S 1 xS 2 , in which topological techniques will come into play. (author). 63 refs

  10. Toponium Tests Of Top-Quark Higgs Bags

    OpenAIRE

    Macpherson, Alick L.; Campbell, Bruce A.

    1993-01-01

    Recently it has been suggested that top quarks, or very massive fourth generation quarks, might surround themselves with a Higgs "bag" of deformation of the Higgs expectation value from its vacuum magnitude. In this paper we address the question of whether such nonlinear Higgs-top interaction effects are subject to experimental test. We first note that if top quarks were necessarily accompanied by Higgs "bags", then top quark weak decay would involve the sudden disruption of the Higgs "bag", ...

  11. Potential Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in the Neuse River Basin: a Modeling Investigation Using CMAQ and SWAT

    Science.gov (United States)

    There has been extensive analysis of Clean Air Act Amendment (CAAA) regulation impacts to changes in atmospheric nitrogen deposition; however, few studies have focused on watershed nitrogen transfer particularly regarding long-term predictions. In this study, we investigated impa...

  12. The Effective Design of Bean Bag as a Vibroimpact Damper

    Directory of Open Access Journals (Sweden)

    A.Q. Liu

    2000-01-01

    Full Text Available The technique of a bean bag damper has been effectively applied in many engineering fields to control the vibroimpact of a structural system. In this study, the basic parameters responsible for the design of an effective bean bag: the size of beans, the mass ratio of the bean bag to the structure to which it is attached, the clearance distance and the position of the bag, are studied by both theoretical and experimental analyses. These will provide a better understanding of the performance of the bean bag for optimisation of damper design. It was found that reducing the size of beans would increase the exchange of momentum in the system due to the increase in the effective contact areas. Within the range of mass ratios studied, the damping performance of the damper was found to improve with higher mass ratios. There was an optimum clearance for any specific damper whereby the maximum attenuation could be achieved. The position of the bag with respect to nodes and antipodes of the primary structure determined the magnitude of attenuation attainable. Furthermore, the limitations of bean bags have been identified and a general criteria for the design of a bean bag damper has been formulated based on the study undertaken. It was shown that an appropriately configured bean bag damper was capable of reducing the amplitude of vibration by 80% to 90%.

  13. Two cases of death due to plastic bag suffocation.

    Science.gov (United States)

    Nadesan, K; Beng, O B

    2001-01-01

    Deaths due to plastic bag suffocation or plastic bag asphyxia are not reported in Malaysia. In the West many suicides by plastic bag asphyxia, particularly in the elderly and those who are chronically and terminally ill, have been reported. Accidental deaths too are not uncommon in the West, both among small children who play with shopping bags and adolescents who are solvent abusers. Another well-known but not so common form of accidental death from plastic bag asphyxia is sexual asphyxia, which is mostly seen among adult males. Homicide by plastic bag asphyxia too is reported in the West and the victims are invariably infants or adults who are frail or terminally ill and who cannot struggle. Two deaths due to plastic bag asphyxia are presented. Both the autopsies were performed at the University Hospital Mortuary, Kuala Lumpur. Both victims were 50-year old married Chinese males. One death was diagnosed as suicide and the other as sexual asphyxia. Sexual asphyxia is generally believed to be a problem associated exclusively with the West. Specific autopsy findings are often absent in deaths due to plastic bag asphyxia and therefore such deaths could be missed when some interested parties have altered the scene and most importantly have removed the plastic bag. A visit to the scene of death is invariably useful.

  14. Radiative decays of vector mesons in the chiral bag model

    International Nuclear Information System (INIS)

    Tabachenko, A.N.

    1988-01-01

    A new model of radiative π-meson decays of vector mesons in the chiral bag model is proposed. The quark-π-meson interaction has the form of a pseudoscalar coupling and is located on the bag surface. The vector meson decay width depends on the quark masses, the π-meson decay constant, the radius of the bag, and the free parameter Z 2 , which specifies the disappearance of the bag during the decay. The obtained results for the omega- and p-decay widths are in satisfactory agreement with the experiment

  15. BAG3 is involved in neuronal differentiation and migration.

    Science.gov (United States)

    Santoro, Antonietta; Nicolin, Vanessa; Florenzano, Fulvio; Rosati, Alessandra; Capunzo, Mario; Nori, Stefania L

    2017-05-01

    Bcl2-associated athanogene 3 (BAG3) protein belongs to the family of co-chaperones interacting with several heat shock proteins. It plays a key role in protein quality control and mediates the clearance of misfolded proteins. Little is known about the expression and cellular localization of BAG3 during nervous system development and differentiation. Therefore, we analyze the subcellular distribution and expression of BAG3 in nerve-growth-factor-induced neurite outgrowth in PC12 cells and in developing and adult cortex of mouse brain. In differentiated PC12 cells, BAG3 was localized mainly in the neuritic domain rather than the cell body, whereas in control cells, it appeared to be confined to the cytoplasm near the nuclear membrane. Interestingly, the change of BAG3 localization during neuronal differentiation was associated only with a slight increase in total BAG3 expression. These data were coroborated by transmission electron microscopy showing that BAG3 was confined mainly within large dense-core vesicles of the axon in differentiated PC12 cells. In mouse developing cortex, BAG3 appeared to be intensely expressed in cellular processes of migrating cells, whereas in adult brain, a diffuse expression of low to medium intensity was detected in neuronal cell bodies. These findings suggest that BAG3 expression is required for neuronal differentiation and migration and that its role is linked to a change in its distribution pattern rather than to an increase in its protein expression levels.

  16. Potential regulation on the climatic effect of Tibetan Plateau heating by tropical air-sea coupling in regional models

    Science.gov (United States)

    Wang, Ziqian; Duan, Anmin; Yang, Song

    2018-05-01

    Based on the conventional weather research and forecasting (WRF) model and the air-sea coupled mode WRF-OMLM, we investigate the potential regulation on the climatic effect of Tibetan Plateau (TP) heating by the air-sea coupling over the tropical Indian Ocean and western Pacific. Results indicate that the TP heating significantly enhances the southwesterly monsoon circulation over the northern Indian Ocean and the South Asia subcontinent. The intensified southwesterly wind cools the sea surface mainly through the wind-evaporation-SST (sea surface temperature) feedback. Cold SST anomaly then weakens monsoon convective activity, especially that over the Bay of Bengal, and less water vapor is thus transported into the TP along its southern slope from the tropical oceans. As a result, summer precipitation decreases over the TP, which further weakens the TP local heat source. Finally, the changed TP heating continues to influence the summer monsoon precipitation and atmospheric circulation. To a certain extent, the air-sea coupling over the adjacent oceans may weaken the effect of TP heating on the mean climate in summer. It is also implied that considerations of air-sea interaction are necessary in future simulation studies of the TP heating effect.

  17. Structure functions in the chiral bag model

    International Nuclear Information System (INIS)

    Sanjose, V.; Vento, V.; Centro Mixto CSIC/Valencia Univ., Valencia

    1989-01-01

    We calculate the structure functions of an isoscalar nuclear target for the deep inelastic scattering by leptons in an extended version of the chiral bag model which incorporates the qanti q structure of the pions in the cloud. Bjorken scaling and Regge behavior are satisfied. The model calculation reproduces the low-x behavior of the data but fails to explain the medium- to large-x behavior. Evolution of the quark structure functions seem inevitable to attempt a connection between the low-energy models and the high-energy behavior of quantum chromodynamics. (orig.)

  18. Structure functions in the chiral bag model

    Energy Technology Data Exchange (ETDEWEB)

    Sanjose, V.; Vento, V.

    1989-07-13

    We calculate the structure functions of an isoscalar nuclear target for the deep inelastic scattering by leptons in an extended version of the chiral bag model which incorporates the qanti q structure of the pions in the cloud. Bjorken scaling and Regge behavior are satisfied. The model calculation reproduces the low-x behavior of the data but fails to explain the medium- to large-x behavior. Evolution of the quark structure functions seem inevitable to attempt a connection between the low-energy models and the high-energy behavior of quantum chromodynamics. (orig.).

  19. Gravitational bags and solitary cosmological evolution

    International Nuclear Information System (INIS)

    Davidson, A.; Guendelman, E.I.

    1989-01-01

    The role played by the sophisticated scalar potential, dictated by spontaneous compactification, is analyzed. A fine-tuning is mandatory for achieving asymptotic flatness. Two main aspects are studied. 1. The three-fold spherically symmetric case exhibits localized four-dimensional objects, to be referred to as ''gravitational bags''. These are cores of scalar fields confined by means of a cosmic domain wall, whose size only slightly exceeds equal-mass black holes. 2. The cosmological case introduces a novel scenario of ''solitary evolution''. Triggered by the collapse of the extra dimensions, the universe undergoes an inflationary stage before settling in an oscillating fashion, in its ground state. (orig.)

  20. Efficacy of humidity retention bags for the reduced adsorption and improved cleaning of tissue proteins including prion-associated amyloid to surgical stainless steel surfaces.

    Science.gov (United States)

    Secker, T J; Pinchin, H E; Hervé, R C; Keevil, C W

    2015-01-01

    Increasing drying time adversely affects attachment of tissue proteins and prion-associated amyloid to surgical stainless steel, and reduces the efficacy of commercial cleaning chemistries. This study tested the efficacy of commercial humidity retention bags to reduce biofouling on surgical stainless steel and to improve subsequent cleaning. Surgical stainless steel surfaces were contaminated with ME7-infected brain homogenates and left to dry for 15 to 1,440 min either in air, in dry polythene bags or within humidity retention bags. Residual contamination pre/post cleaning was analysed using Thioflavin T/SYPRO Ruby dual staining and microscope analysis. An increase in biofouling was observed with increased drying time in air or in sealed dry bags. Humidity retention bags kept both protein and prion-associated amyloid minimal across the drying times both pre- and post-cleaning. Therefore, humidity bags demonstrate a cheap, easy to implement solution to improve surgical instrument reprocessing and to potentially reduce associated hospital acquired infections.

  1. Head holder using negative pressure bag packed with plastic beads in xenon CT CBF study

    International Nuclear Information System (INIS)

    Araki, Yuzo; Sakai, Noboru

    2003-01-01

    Employing analysis of cerebral blood flow (CBF) confidence maps, we investigated the usefulness of a head holder using a negative pressure bag packed with plastic beads in a xenon CT CBF study. A total of 272 consecutive patients for the CBF study were enrolled and classified into 3 groups: 88 patients with a negative pressure bag (M group), 87 patients with an air pillow (A group), and 97 patients with a sponge pillow (S group). The degree of effect of head movements on the CBF measurement in each patient was expressed as a confidence value (mean of the confidence values at one CT slice). The mean of confidence value in the M group (0.461) was statistically lower than that in the A group (0.866) and that in the S group (1.043). These findings showed that the head holder described here was useful for obtaining CBF maps of high quality in a xenon CT CBF study. (author)

  2. Royal Decree 1749/1984 of 1 August approving the national regulations on the safe transport of dangerous goods by air together with technical instructions for the safe transport of dangerous goods by air

    International Nuclear Information System (INIS)

    1984-01-01

    This Royal Decree approves the national Regulations on the safe transport of dangerous goods by air. The Regulations as well as the attached detailed technical instructions are based on the 1981 revised text of the Annex concerning dangerous goods of the Chicago Convention on International Civil Aviation. It also covers radioactive materials. (NEA) [fr

  3. BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Chandan Kanta Das

    2018-03-01

    Full Text Available Target-specific treatment modalities are currently not available for triple-negative breast cancer (TNBC, and acquired chemotherapy resistance is a primary obstacle for the treatment of these tumors. Here we employed derivatives of BT-549 and MDA-MB-468 TNBC cell lines that were adapted to grow in the presence of either 5-Fluorouracil, Doxorubicin or Docetaxel in an aim to identify molecular pathways involved in the adaptation to drug-induced cell killing. All six drug-adapted BT-549 and MDA-MB-468 cell lines displayed cross resistance to chemotherapy and decreased apoptosis sensitivity. Expression of the anti-apoptotic co-chaperone BAG3 was notably enhanced in two thirds (4/6 of the six resistant lines simultaneously with higher expression of HSP70 in comparison to parental controls. Doxorubicin-resistant BT-549 (BT-549rDOX20 and 5-Fluorouracil-resistant MDA-MB-468 (MDA-MB-468r5-FU2000 cells were chosen for further analysis with the autophagy inhibitor Bafilomycin A1 and lentiviral depletion of ATG5, indicating that enhanced cytoprotective autophagy partially contributes to increased drug resistance and cell survival. Stable lentiviral BAG3 depletion was associated with a robust down-regulation of Mcl-1, Bcl-2 and Bcl-xL, restoration of drug-induced apoptosis and reduced cell adhesion in these cells, and these death-sensitizing effects could be mimicked with the BAG3/Hsp70 interaction inhibitor YM-1 and by KRIBB11, a selective transcriptional inhibitor of HSF-1. Furthermore, BAG3 depletion was able to revert the EMT-like transcriptional changes observed in BT-549rDOX20 and MDA-MB-468r5-FU2000 cells. In summary, genetic and pharmacological interference with BAG3 is capable to resensitize TNBC cells to treatment, underscoring its relevance for cell death resistance and as a target to overcome therapy resistance of breast cancer.

  4. 76 FR 59271 - Migratory Bird Hunting; Late Seasons and Bag and Possession Limits for Certain Migratory Game Birds

    Science.gov (United States)

    2011-09-26

    ...-0014; 91200-1231-9BPP-L2] RIN 1018-AX34 Migratory Bird Hunting; Late Seasons and Bag and Possession Limits for Certain Migratory Game Birds AGENCY: Fish and Wildlife Service, Interior. ACTION: Final rule... of migratory birds is prohibited unless specifically provided for by annual regulations. This rule...

  5. Market effects of environmental regulation: coal, railroads, and the 1990 Clean Air Act

    Energy Technology Data Exchange (ETDEWEB)

    Busse, M.R.; Keohane, N.O. [University of California Berkeley, Berkeley, CA (United States)

    2007-01-01

    Many environmental regulations encourage the use of 'clean' inputs. When the suppliers of such an input have market power, environmental regulation will affect not only the quantity of the input used but also its price. We investigate the effect of the Title IV emissions trading program for sulfur dioxide on the market for low-sulfur coal. We find that the two railroads transporting coal were able to price discriminate on the basis of environmental regulation and geographic location. Delivered prices rose for plants in the trading program relative to other plants, and by more at plants near a low-sulfur coal source.

  6. HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy.

    Science.gov (United States)

    Marsh, Noelle M; Wareham, Angela; White, Bryan G; Miskiewicz, Ewa I; Landry, Jacques; MacPhee, Daniel J

    2015-05-01

    The small heat shock protein (HSP) B family of proteins are a group of molecular chaperones that enable tissues to adapt to changes in their local environments during differentiation, stress, or disease conditions. The objective of this research was to characterize the expression of HSPB8 and its cochaperone Bcl2-associated athanogene 3 (BAG3) in nonpregnant (NP) and pregnant rat myometrium during myometrial programming. Rat myometrium was collected from NP and pregnant rats as well as 1 day postpartum (PP) and samples prepared for immunoblot and immunofluorescence analysis. Immunoblot analysis determined that HSPB8 protein expression was significantly elevated at Day (D) 15, D17, and D19 compared to expression at NP and D6, while BAG3 expression was significantly elevated at D15 compared to NP, and D17 compared to NP, D6, D23, and PP time points (P BAG3 were predominantly localized to myometrial cells throughout pregnancy, with intense cytoplasmic HSPB8 and BAG3 detection on D15 and D17 in both longitudinal and circular muscle layers. Immunoblot analysis of HSPB8 and BAG3 protein expression in myometrium from unilateral pregnancies also revealed that expression of both proteins was significantly increased at D15 in gravid compared to nongravid horns. Thus, HSPB8 and BAG3 are highly expressed during the synthetic phase of myometrial differentiation marked by initiation of uterine distension and myometrial hypertrophy. HSPB8 and BAG3 could be regulators of the protein quality control required for this process. © 2015 by the Society for the Study of Reproduction, Inc.

  7. Federal Air Pollutant Emission Regulations and Preliminary Estimates of Potential-to-Emit from Biorefineries. Pathway #1: Dilute-Acid and Enzymatic Deconstruction of Biomass-to-Sugars and Biological Conversion of Sugars-to-Hydrocarbons

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yimin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bhatt, Arpit [National Renewable Energy Lab. (NREL), Golden, CO (United States); Heath, Garvin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thomas, Mae [Eastern Research Group, Lexington, MA (United States); Renzaglia, Jason [Eastern Research Group, Lexington, MA (United States)

    2016-02-01

    Biorefineries are subject to environmental laws, including complex air quality regulations that aim to protect and improve the quality of the air. These regulations govern the amount of certain types of air pollutants that can be emitted from different types of emission sources. To determine which federal air emission regulations potentially apply to the sugars-to-hydrocarbon (HC) biorefinery, we first identified the types of regulated air pollutants emitted to the ambient environment by the biorefinery or from specific equipment. Once the regulated air pollutants are identified, we review the applicability criteria of each federal air regulation to determine whether the sugars-to-HC biorefinery or specific equipment is subject to it. We then estimate the potential-to-emit of pollutants likely to be emitted from the sugars-to-HC biorefinery to understand the air permitting requirements.

  8. Federal Air Pollutant Emission Regulations and Preliminary Estimates of Potential-to-Emit from Biorefineries, Pathway #2: Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Fast Pyrolysis and Hydrotreating Bio-oil Pathway

    Energy Technology Data Exchange (ETDEWEB)

    Bhatt, Arpit [National Renewable Energy Lab. (NREL), Golden, CO (United States). Strategic Energy Analysis Center. Technology Systems and Sustainability Analysis Group; Zhang, Yimin [National Renewable Energy Lab. (NREL), Golden, CO (United States). Strategic Energy Analysis Center. Technology Systems and Sustainability Analysis Group; Heath, Garvin [National Renewable Energy Lab. (NREL), Golden, CO (United States). Strategic Energy Analysis Center. Technology Systems and Sustainability Analysis Group; Thomas, Mae [Eastern Research Group, Research Triangle Park, NC (United States); Renzaglia, Jason [Eastern Research Group, Research Triangle Park, NC (United States)

    2017-01-01

    Biorefineries are subject to environmental laws, including complex air quality regulations that aim to protect and improve the quality of the air. These regulations govern the amount of certain types of air pollutants that can be emitted from different types of emission sources. To determine which federal air emission regulations potentially apply to the fast pyrolysis biorefinery, we first identified the types of regulated air pollutants emitted to the ambient environment by the biorefinery or from specific equipment. Once the regulated air pollutants are identified, we review the applicability criteria of each federal air regulation to determine whether the fast pyrolysis biorefinery or specific equipment is subject to it. We then estimate the potential-to-emit of pollutants likely to be emitted from the fast pyrolysis biorefinery to understand the air permitting requirements.

  9. 78 FR 59263 - Outer Continental Shelf Air Regulations Consistency Update for California

    Science.gov (United States)

    2013-09-26

    ..., Nitrogen dioxide, Nitrogen oxides, Outer continental shelf, Ozone, Particulate matter, Permits, Reporting... Solvents (Adopted 10/23/78) Rule 325 Crude Oil Production and Separation (Adopted 07/19/01) Rule 326... (Adopted 04/17/97) Rule 805 Air Quality Impact Analysis and Modeling (Adopted 04/17/97) Rule 808 New Source...

  10. Air quality regulation: State implementation of the NAAQS and the nonattainment program of the 1990 Amendments

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The 1970 Amendments to the Clean Air Act required the EPA to establish 'national ambient air quality standards' (NAAQS) for substances that contribute to widespread and pervasive air pollution. Since many areas of the country had not met NAAQS by 1987 and since there was controversy over the EPA's authority to address these nonattainment problems administratively, the 1990 Amendments to the Act were a legal necessity. The new nonattainment requirements are extensive and complex, and will affect industry in a variety of ways. Existing sources could be required to reduce PM-10 precursors (e.g., SO 2 and NO x ), CO, and VOCs in nonattainment areas for those pollutants. The procedures that the EPA adopts to make decisions on nonattainment classifications and state plan revisions could affect control requirements. New and modified sources being permitted in nonattainment areas may face offset and stringent control requirements. These and other provisions of the nonattainment requirements of the Clean Air Act and the 1990 Amendments are discussed in this chapter

  11. 76 FR 29156 - Outer Continental Shelf Air Regulations Consistency Update for California

    Science.gov (United States)

    2011-05-20

    ... response, using the definition of burden provided in 44 U.S.C. 3502(2). The Congressional Review Act, 5 U.S... procedures, Air pollution control, Hydrocarbons, Incorporation by reference, Intergovernmental relations... OCS Sources: Rule 102 Definitions (Adopted 09/20/10). Rule 103 Severability (Adopted 10/23/78). Rule...

  12. QCD inspired bag model of quarkonium

    International Nuclear Information System (INIS)

    Hasenfratz, P.; Horgan, R.R.; Kuti, J.; Richard, J.M.

    1981-01-01

    The QCD motivated bag model is applied to heavy quark-antiquark systems. The effect of colored glue in the model is shown to explain the rapid cross-over of the static QQ potential from the asymptotically free Coulomb region into the linear confinement regime. The spin-dependent force between static quarks is derived in Coulomb gauge from the exchange of a confined transverse gluon. The dimensional bag parameter Λ/sub B/ = 235 MeV and the quark-gluon coupling constant α = 0.38 as defined at r/sub QQ/approx.0.2 fermi are determined from a good fit of the cc-bar and bb-bar spectra. The fit is in serious disagreement with the widely accepted MIT parameters. As an important test of our model, we calculate the rich spectrum of QQ glue states. In UPSILON particle spectroscopy we predict a narrow QQ glue state with exotic quantum numbers J/sup PC/ = 1 -+ below the BB threshold. Its experimental confirmation would be the first direct evidence for colored glue in the hadron spectrum

  13. QCD inspired bag model of quarkonium

    CERN Document Server

    Hasenfratz, Peter; Kuti, Julius; Richard, J M

    1981-01-01

    The QCD motivated bag model is applied to heavy quark-antiquark systems. The effect of colored glue in the model is shown to explain the rapid cross-over of the static QQ potential from the asymptotically free Coulomb region into the linear confinement regime. The spin-dependent force between static quarks is derived in Coulomb gauge from the exchange of a confined transverse gluon. The dimensional bag parameter Lambda /sub B/=235 MeV and the quark-gluon coupling constant alpha =0.38 as defined at r/sub QQ/ approximately 0.2 fermi are determined from a good fit of the cc and bb spectra. The fit is in serious disagreement with the widely accepted MIT parameters. As an important test of their model, the authors calculate the rich spectrum of QQ glue states. In Upsilon particle spectroscopy they predict a narrow QQglue state with exotic quantum numbers J/sup PC/=1/sup -+/ below the BB threshold. Its experimental confirmation would be the first direct evidence for colored glue in the hadron spectrum. (3 refs).

  14. Hospital discharge bags and breastfeeding at 6 months: data from the infant feeding practices study II.

    Science.gov (United States)

    Sadacharan, Radha; Grossman, Xena; Matlak, Stephanie; Merewood, Anne

    2014-02-01

    Distribution of industry-sponsored formula sample packs to new mothers undermines breastfeeding. Using data from the Infant Feeding Practices Study II (IFPS II), we aimed to determine whether receipt of 4 different types of bags was associated with exclusive breastfeeding during the first 6 months of life. We extracted data from IFPS II questionnaires. Type of discharge bag received was categorized as "formula bag," "coupon bag," "breastfeeding supplies bag," or "no bag". We examined exclusive breastfeeding status at 10 weeks (post hoc) and at 6 months using univariate descriptive analyses and multivariate logistic regression models, controlling for sociodemographic and attitudinal variables. Overall, 1868 (81.4%) of women received formula bags, 96 (4.2%) received coupon bags, 46 (2.0%) received breastfeeding supplies bags, and 284 (12.4%) received no bag. By 10 weeks, recipients of breastfeeding supplies bags or no bag were significantly more likely to be exclusively breastfeeding than formula bag recipients. In the adjusted model, compared to formula bag/coupon bag recipients, recipients of breastfeeding supplies bag/no bag were significantly more likely to breastfeed exclusively for 6 months (odds ratio = 1.58; 95% confidence interval, 1.06-2.36). The vast majority of new mothers received formula sample packs at discharge, and this was associated with reduced exclusive breastfeeding at 10 weeks and 6 months. Bags containing breastfeeding supplies or no bag at all were positively associated with exclusive breastfeeding at 10 weeks and 6 months.

  15. Let's Do It Again: Bagging Equity Premium Predictors

    DEFF Research Database (Denmark)

    Hillebrand, Eric Tobias; Lee, Tae-Hwy; Medeiros, Marcelo C.

    The literature on excess return prediction has considered a wide array of estimation schemes, among them unrestricted and restricted regression coefficients. We consider bootstrap aggregation (bagging) to smooth parameter restrictions. Two types of restrictions are considered: positivity...... by smoothing the restriction through bagging....

  16. Bogota bag in the treatment of abdominal wound dehiscence.

    Science.gov (United States)

    Sukumar, N; Shaharin, S; Razman, J; Jasmi, A Y

    2004-06-01

    A patient who underwent emergency laparotomy for rectal prolapse developed repeated abdominal wound dehiscence and subsequently an enteric fistula. The management of abdominal wound dehiscence is discussed, specifically with regards to the Bogota bag. Use of Bogota bag has been reported worldwide but this may be the first report here.

  17. Storage quality and marketability potential of bagged silage for ...

    African Journals Online (AJOL)

    Bagged sole maize and maize–cowpea silages in three bag sizes were assessed at 42 and 282 d post-ensiling for sensory and chemical quality. A survey of dairy farmers on silage use and preferences was conducted in the Chikwaka communal area and Marirangwe small-scale commercial farming area. Only silage ...

  18. Behaviour of hadron matter within the bag model: Pt. 2

    International Nuclear Information System (INIS)

    Auberson, G.; Savatier, F.

    1988-01-01

    On the basis of the quantum theory of the vibrating bag developed in I, it is worked out the partition function of a gas of hadronic bags. This is done within the small deformation, Van der Waals approximation. The outcome is in full agreement with a previous, less elaborate model of deconfinement phase transition

  19. On the quantisation of one-dimensional bags

    International Nuclear Information System (INIS)

    Fairley, G.T.; Squires, E.J.

    1976-01-01

    The quantisation of one-dimensional MIT bags by expanding the fields as a sum of classical modes and truncating the series after the first term is discussed. The lowest states of a bag in a world containing two scalar quark fields are obtained. Problems associated with the zero-point oscillations of the field are discussed. (Auth.)

  20. Light hadrons in the bag model with broken chiral symmetry

    International Nuclear Information System (INIS)

    Efrosinin, V.P.; Zaikin, D.A.

    1987-01-01

    A version of the bag model with broken chiral symmetry is proposed. A satisfactory description of the experimental data on light hadrons including the pion is obtained. The estimate of the pion-nucleon σ term is given in the framework of this model. The pion and kaon decay constants are calculated. The centre-of-mass motion problem in bag models is discussed

  1. Investigating Comfort Temperatures and Heat Transfer in Sleeping Bags

    Science.gov (United States)

    Hill, Trevor; Hill, Lara

    2017-01-01

    After many years of confusion, thermal performance of sleeping bags has now been quantified and unified using expensive test techniques. Based on Newton's law of cooling, we present a simple inexpensive test and model to check manufacturers' claims on the temperature performance of a range of modern sleeping bags.

  2. Vibration and recoil control of pneumatic hammers. [by air flow pressure regulation

    Science.gov (United States)

    Constantinescu, I. N.; Darabont, A. V.

    1974-01-01

    Vibration sources are described for pneumatic hammers used in the mining industry (pick hammers), in boiler shops (riveting hammers), etc., bringing to light the fact that the principal vibration source is the variation in air pressure inside the cylinder. The present state of the art of vibration control of pneumatic hammers as it is practiced abroad, and the solutions adopted for this purpose, are discussed. A new type of pneumatic hammer with a low noise and vibration level is presented.

  3. Construction and testing of a blower-door assembly for regulation of air pressure within structures

    International Nuclear Information System (INIS)

    Steele, W.D.

    1987-09-01

    The Technical Measurements Center is evaluating several methods to decrease the time required to determine an annual average radon-daughter concentration in structures. One method involves stabilizing the air pressure within the structure at a constant pressure with reference to external atmospheric or soil-gas pressure. This report describes the construction and preliminary testing of a blower-door system to maintain a constant differential air pressure within a structure. The blower-door assembly includes a collapsible frame and a large fan to occlude a doorway, a damper with an actuator to control air flow, a controller to drive the damper actuator, and a pressure transducer to measure the differential pressure. Preliminary testing of the system indicates that pressure within the structure in the range of 1 to 20 Pascals can be held to within approximately +-1 Pa of the set point. Further testing of the blower-door system is planned to provide data on the applicability of this method to short-duration tests for annual average radon-daughter concentration estimates. 13 figs., 1 tab

  4. California's program: Indoor air problems aren't amenable to regulation

    International Nuclear Information System (INIS)

    Wesolowski, J.

    1993-01-01

    In 1982, California's legislature established an Indoor Air Quality Program (CIAQP) in the Department of Health Services to carry out research on the nature and extent of the indoor air problem (excluding industrial worksites), to find appropriate mitigation measures, and to promote and coordinate the efforts of other state agencies. Since indoor air problems usually are not amenable to regulatory solutions, regulatory authority was not included in the mandate. The program conducts research into a wide range of contaminants--radon, asbestos, formaldehyde, carbon monoxide, volatile organic compounds, environmental tobacco smoke (ETS), as well as into biological aerosols that cause such diseases as Legionnaires disease, tuberculosis, allergies, and asthma. Studies are also carried out to better understand the Sick Building Syndrome. The research includes field surveys to determine the exposure of the population to specific contaminants and experiments in the laboratory to develop protocols for reducing exposures. The research emphasizes measurement of exposure--concentration multiplied by the time a person is exposed--as opposed to measurement of concentration only

  5. Chiral bag model with constituent quarks: topological and nontopological decisions

    International Nuclear Information System (INIS)

    Malakhov, I.Yu.; Sveshnikov, K.A.; Fedorov, S.M.; Khalili, M.F.

    2002-01-01

    The three-phase modification of the hybrid chiral bag containing along with asymptotic freedom and hadronization phases and also intermediate phase of the constituent quarks is considered. The self-consistent solutions of the equations of the model in the (1 + 1)-dimensional case are determined with an account of the fermion vacuum polarization effects. The bag renormalized complete energy is studied as a function of the parameters characterizing the bag geometry and its topological (baryon) charge. It is shown that for nonzero topological charge there exists the whole series of configurations representing the local minima of the bag complete energy and containing all three phases, whereas the bag energy minimum in the nontopological case corresponds to zero dimensions of the area corresponding to asymptotic freedom phase [ru

  6. Vector meson decays in the chiral bag model

    International Nuclear Information System (INIS)

    Maxwell, O.V.; Jennings, B.K.

    1985-01-01

    Vector meson decays are examined in a model where a confined quark and antiquark annihilate, producing a pair of elementary pseudoscalar mesons. Two versions of the pseudoscalar meson-quark interaction are employed, one where the coupling is restricted to the bag surface and one where it extends throughout the bag volume. Energy conservation is ensured in the model through insertion of exponential factors containing the bag energy at each interaction vertex. To guarantee momentum conservation, a wave-packet description is utilized in which the decay widths are normalized by a factor involving the overlap of the initial bag state with the confined qanti q state of zero momentum. With either interaction, the model yields a value for the p-width that exceeds the empirical width by a factor two. For the Ksup(*) and PHI mesons, the computed widths depend strongly on the interaction employed. Implications of these results for chiral bag models are discussed. (orig.)

  7. MiR-143 enhances the antitumor activity of shikonin by targeting BAG3 expression in human glioblastoma stem cells.

    Science.gov (United States)

    Liu, Jing; Qu, Cheng-Bin; Xue, Yi-Xue; Li, Zhen; Wang, Ping; Liu, Yun-hui

    Therapeutic applications of microRNAs (miRNAs) in chemotherapy were confirmed to be valuable, but there is rare to identify their specific roles and functions in shikonin treatment toward tumors. Here, for the first time, we reported that miR-143 played a critical role in the antitumor activity of shikonin in glioblastoma stem cells (GSCs). The results showed that the expression of miR-143 was downregulated in shikonin treated GSCs within 24 h. MiR-143 overexpression significantly enhanced the inhibitory effect of shikonin toward GSCs on cell viability. Besides, miR-143 overexpression caused a significant increase in the apoptotic fraction and made apoptosis occur earlier. Further investigation identified that BAG3, an apoptotic regulator, was a functional target of miR-143 in shikonin treated GSCs. The expression of BAG3 was upregulated in shikonin treated GSCs within 24 h. MiR-143 overexpression significantly reversed the high expression of BAG3 in shikonin treated GSCs. Moreover, it was confirmed that the enhanced cytotoxicity of shikonin by miR-143 overexpression was reversed by BAG3 overexpression both in vitro and in vivo, suggesting that the enhanced tumor suppressive effects by miR-143 overexpression was at least partly through the regulation of BAG3. Taken together, for the first time, our results demonstrate that miR-143 could enhance the antitumor activity of shikonin toward GSCs through reducing BAG3 expression, which may provide a novel therapeutic strategy for enhancing the treatment efficacy of shikonin toward GSCs. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Effects of bagging materials and CaCl2 spray on fruit calcium concentration in fruit-bagged apple trees

    International Nuclear Information System (INIS)

    Yim, Y.J.; Choi, J.S.; Kim, S.B.

    1989-01-01

    This experiment was carried out to investigate the effects of bagging materials and CaCl 2 spray on fruit Ca concentration in fruit-bagged apple trees (Malus domestica Borkh.). No difference was noted in fruit Ca concentration among bagging materials during the growing season. And also, there was no difference in fruit Ca concentration between bagged and non-bagged fruits. The fruit flesh Ca concentration of bagged fruits was significantly lower than that of non-bagged fruits in the same tree, which 0.5 % CaCl 2 was sprayed 5 times in the late growing season. The radioactivity of 45 Ca was highest in the sprayed shoot leaves and bark, while only a trace amount was detected in the fruit and shoot proximate to the treated shoot 3 weeks after 3 times application of 45 CaCl 2 (5 micro Ci/ml). As a result, it is confirmed that the Ca once accumulated in a specific part is hardly retranslocated. Therefore, it is concluded that Ca foliar spray to the fruit-bagged tree has no influence on Ca concentration in the fruit

  9. 76 FR 43230 - Outer Continental Shelf Air Regulations Consistency Update for Virginia

    Science.gov (United States)

    2011-07-20

    ... protected. The http://www.regulations.gov Web site is an ``anonymous access'' system, which means EPA will... public docket and made available on the Internet. If you submit an electronic comment, EPA recommends... the Internet and will be publicly available only in hard copy form. Publicly available docket...

  10. Non-topological soliton bag model

    International Nuclear Information System (INIS)

    Wilets, L.

    1986-01-01

    The Friedberg-Lee soliton model, which effects confinement by a quantal scalar field, is discussed. The Lagrangian for the non-topological soliton model is the usual QCD Lagrangian supplemented by a non-linear scalar sigma field term. Static solutions to the field equations are considered in the mean field approximation. Small amplitude oscillations are discussed. Quantum alternatives to the mean field approximation are also considered. Methods of momentum projection and Lorentz boost are described, and the generator coordinate method is discussed. Calculations of the N-N interaction are reviewed briefly. Also discussed is one-gluon exchange, as well as the pion and dressing of the baryons. The hadron states are summarized. One loop quantum corrections are discussed briefly. Work in progress is mentioned in the areas of N-anti N annihilation, the many bag problem, and a Pauli equation for the nucleon. 31 refs

  11. Heavy metals dispersion during thermal treatment of plastic bags and its recovery.

    Science.gov (United States)

    Alam, Ohidul; Wang, Sijia; Lu, Wentao

    2018-04-15

    One of the main worries for thermal treatment of plastic bag (PB) is the air pollution resulting from heavy metal (HM) evaporation and emission. The quest of the study was to investigate their fate during thermal treatment varying with temperature and atmosphere to explore the appropriate treatment technology. Four commonly consumed polymer bags such as PE, HDPE, LDPE and PVC were selected for the analysis. The elemental compositions, heating values and total metal contents of the samples were measured by an elemental analyzer, a sulphur/halogen analyzer, a bomb calorimeter and an ICP-OES, respectively. Thermal treatments of the samples were conducted in a tube furnace at 350, 550, 650, 750, and 850 °C with 1 L/min air or N 2 gas flow, respectively. 5% HNO 3 /10% H 2 O 2 solution was used for absorbing metals from gas phase, and then HM distributions both in flue gas and bottom ash were determined. Results revealed that the lower heating values of HDPE, LDPE, PVC and PE bags were 33.32, 34.28, 24.82 and 36.7 MJ/kg, respectively indicating energy recovery potential. Thermal treatment showed the maximum mass reduction (>90%) of PB at 850 °C. The higher percentage of metals was distributed in ash at initial temperature that promoted to gas with rise of temperature. The used absorption solution exhibited tremendous quantity of metals recovery. However, there was no significant difference between using air and N 2 gas flow during treatment of PB. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. Degradation of plastic compost bags used for yard waste

    International Nuclear Information System (INIS)

    Taber, H.G.; Cox, D.F.

    1993-01-01

    Three trials, beginning June, July, and September 1991, examined the breakdown of photodegradable plastic bags. The plastic contained a light-sensitive compound dissolved in the polymer to hasten degradation. The bags were placed in east-west rows on bare ground. Other factors studied included turning the bags over either every 3 or 7 days and either filling the bags with fresh grass clippings or leaving them empty. Strength loss was determined with a hand-held puncture tester. Strength increased initially by 36%, 32%, and 63% in the three trials, respectively. The bags took 33, 35, and 64 days to reach brittleness (puncture strength of 180 g) in the three trials, respectively. Once degradation began, all trials showed similar rates of decline. However, the degradation began 7 days after exposure in the first two trials, but not until 14 days after exposure in the September trial. The addition of grass clippings to the bags increased the initial strength and delayed the onset of degradation. Turning the bags every 3 days rather than every 7 did not affect degradation

  13. PICS bags safely store unshelled and shelled groundnuts in Niger.

    Science.gov (United States)

    Baributsa, D; Baoua, I B; Bakoye, O N; Amadou, L; Murdock, L L

    2017-05-01

    We conducted an experiment in Niger to evaluate the performance of hermetic triple layer (Purdue Improved Crop Storage- PICS) bags for the preservation of shelled and unshelled groundnut Arachis hypogaea L. Naturally-infested groundnut was stored in PICS bags and woven bags for 6.7 months. After storage, the average oxygen level in the PICS bags fell from 21% to 18% (v/v) and 21%-15% (v/v) for unshelled and shelled groundnut, respectively. Identified pests present in the stored groundnuts were Tribolium castaneum (Herbst), Corcyra cephalonica (Stainton) and Cryptolestes ferrugineus (Stephens). After 6.7 months of storage, in the woven bag, there was a large increase in the pest population accompanied by a weight loss of 8.2% for unshelled groundnuts and 28.7% for shelled groundnut. In PICS bags for both shelled and unshelled groundnuts, by contrast, the density of insect pests did not increase, there was no weight loss, and the germination rate was the same compared to that recorded at the beginning of the experiment. Storing shelled groundnuts in PICS bags is the most cost-effective way as it increases the quantity of grain stored.

  14. Hazardous Air Pollutants

    Science.gov (United States)

    ... Search Main menu Environmental Topics Air Bed Bugs Chemicals and Toxics Environmental Information by Location Greener Living Health Land, ... regulate toxic air pollutants, also known as air toxics, from categories of industrial facilities in two phases . About Hazardous Air Pollutants ...

  15. Assessment of codes, by-laws and regulations relating to air wells in building design

    Science.gov (United States)

    Fadzil, Sharifah Fairuz Syed; Karamazaman, Nazli

    2017-10-01

    Codes and by-laws concerning air well design (for buildings and lavatories) in Malaysia has been established in the Malaysian Uniform Building By-Laws UBBL number 40 (1) and (2) since the 1980s. Wells are there to fulfill the ventilation and daylighting requirements. The minimum well area according to building storey height are compared between UBBL and the Singapore's well requirements from the Building Construction Authority BCA. A visual and graphical representation (with schematics building and well diagrams drawn to scale) of the minimum well sizes and dimensions is given. It can be seen that if the minimum requirement of well size is used for buildings above 8 storeys high, a thin well resulted which is not proportionate to the building height. A proposed dimension is graphed and given to be used in the UBBL which translated to graphics (3 dimensional buildings drawn to scale) created a much better well proportion.

  16. The Cheshire Cat principle applied to hybrid bag models

    International Nuclear Information System (INIS)

    Nielsen, H.B.; Wirzba, A.

    1987-05-01

    Here is argued for the Cheshire Cat point of view according to which the bag (itself) has only notational, but no physical significance. It is explained in a 1+1 dimensional exact Cheshire Cat model how a fermion can escape from the bag by means of an anomaly. We also suggest that suitably constructed hybrid bag models may be used to fix such parameters of effective Lagrangians that can otherwise be obtained from experiments only. This idea is illustrated in a calculation of the mass of the pseudoscalar η' meson in 1+1 dimension. Thus there is hope to find a construction principle for a phenomenologically sensible model. (orig.)

  17. Attractive Casimir effect in an infrared modified gluon bag model

    International Nuclear Information System (INIS)

    Oxman, L.E.; Amaral, R.L.P.G.; Svaiter, N.F.

    2005-01-01

    In this work, we are motivated by previous attempts to derive the vacuum contribution to the bag energy in terms of familiar Casimir energy calculations for spherical geometries. A simple infrared modified model is introduced which allows studying the effects of the analytic structure as well as the geometry in a clear manner. In this context, we show that if a class of infrared vanishing effective gluon propagators is considered, then the renormalized vacuum energy for a spherical bag is attractive, as required by the bag model to adjust hadron spectroscopy

  18. Connection between hydrodynamic, water bag and Vlasov models

    International Nuclear Information System (INIS)

    Gros, M.; Bertrand, P.; Feix, M.R.

    1978-01-01

    The connection between hydrodynamic, water bag and Vlasov models is still under consideration with numerical experiments. For long wavelength, slightly non linear excitations and initial preparations such as the usual adiabatic invariant Pn -3 is space independent, the hydrodynamic model is equivalent to the water bag, and for long wavelengths a nice agreement is found with the full numerical solution of the Vlasov equation. For other initial conditions when the water bag cannot be defined, the hydrodynamic approach does not represent the correct behaviour. (author)

  19. Regulate the culture: the police intervention in musical practices (Buenos Aires, 1820-1833

    Directory of Open Access Journals (Sweden)

    Guillermina Mariel Guillamon

    2017-03-01

    Full Text Available The aim of this work is to analyze what were the main areas of intervention of the police respect the musical culture. To do this, at first we inquire about the action of musicians, theater manager and officials of the provincial government at the time of claim and regulate activities, contracts and materials spaces through the police. In a second part, we aprroach about that that was enunciated as part of the " desirable order” for activities and musical practices , customs and habits of the public frequent the theater Coliseo Provisional, rights and obligations of the theater manager , musicians and government.

  20. Effects of biodiesel on emissions of regulated air pollutants and polycyclic aromatic hydrocarbons under engine durability testing

    International Nuclear Information System (INIS)

    Hsi-Hsien Yang; Shu-Mei Chien; Mei-Yu Lo; John Chi-Wei Lan; Wen-Chang Lu; Yong-Yuan Ku

    2007-01-01

    An 80,000-km durability test was performed on two engines using diesel and biodiesel (methyl ester of waste cooking oil) as fuel in order to examine emissions resulting from the use of biodiesel. The test biodiesel (B20) was blended with 80% diesel and 20% methyl ester derived from waste cooking oil. Emissions of regulated air pollutants, including CO, HC, NO x , particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) were measured at 20,000-km intervals. The identical-model engines were installed on a standard dynamometer equipped with a dilution tunnel used to measure the pollutants. To simulate real-world driving conditions, emission measurements were made in accordance with the United States Environmental Protection Agency (USEPA) FTP transient cycle guidelines. At 0 km of the durability test, HC, CO and PM emission levels were lower for the B20 engine than those for diesel. After running for 20,000 km and longer, they were higher. However, the deterioration coefficients for these regulated air pollutants were not statistically higher than 1.0, implying that the emission factors do not increase significantly after 80,000 km of driving. Total (gaseous+particulate phase) PAH emission levels for both B20 and diesel decreased as the driving mileage accumulated. However, for the engine using B20 fuel, particulate PAH emissions increased as engine mileage increased. The average total PAH emission factors were 1097 and 1437 μg bhp h -1 for B20 and diesel, respectively. For B20, the benzo[a]pyrene equivalence emission factors were 0.77, 0.24, 0.20, 7.48, 5.43 and 14.1 μg bhp h -1 for 2-, 3-, 4-, 5-, 6-ringed and total PAHs. Results show that B20 use can reduce both PAH emission and its corresponding carcinogenic potency. (author)

  1. Effects of biodiesel on emissions of regulated air pollutants and polycyclic aromatic hydrocarbons under engine durability testing

    Energy Technology Data Exchange (ETDEWEB)

    Hsi-Hsien Yang; Shu-Mei Chien; Mei-Yu Lo [Chaoyang University of Technology, Wufong (China). Dept. of Environmental Engineering and Management; John Chi-Wei Lan [Yuan Ze University (China). Dept. of Chemical Engineering and Materials Science; Wen-Chang Lu [Industrial Technology Research Institute, Hsinchu (China). New Energy Div.; Yong-Yuan Ku [Automotive Research and Testing Center, Chunhwa (China). Diesel Vehicle Section

    2007-11-15

    An 80,000-km durability test was performed on two engines using diesel and biodiesel (methyl ester of waste cooking oil) as fuel in order to examine emissions resulting from the use of biodiesel. The test biodiesel (B20) was blended with 80% diesel and 20% methyl ester derived from waste cooking oil. Emissions of regulated air pollutants, including CO, HC, NO{sub x}, particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) were measured at 20,000-km intervals. The identical-model engines were installed on a standard dynamometer equipped with a dilution tunnel used to measure the pollutants. To simulate real-world driving conditions, emission measurements were made in accordance with the United States Environmental Protection Agency (USEPA) FTP transient cycle guidelines. At 0 km of the durability test, HC, CO and PM emission levels were lower for the B20 engine than those for diesel. After running for 20,000 km and longer, they were higher. However, the deterioration coefficients for these regulated air pollutants were not statistically higher than 1.0, implying that the emission factors do not increase significantly after 80,000 km of driving. Total (gaseous+particulate phase) PAH emission levels for both B20 and diesel decreased as the driving mileage accumulated. However, for the engine using B20 fuel, particulate PAH emissions increased as engine mileage increased. The average total PAH emission factors were 1097 and 1437 {mu}g bhp h{sup -1} for B20 and diesel, respectively. For B20, the benzo[a]pyrene equivalence emission factors were 0.77, 0.24, 0.20, 7.48, 5.43 and 14.1 {mu}g bhp h{sup -1} for 2-, 3-, 4-, 5-, 6-ringed and total PAHs. Results show that B20 use can reduce both PAH emission and its corresponding carcinogenic potency. (author)

  2. Vacuum-bag-only processing of composites

    Science.gov (United States)

    Thomas, Shad

    Ultrasonic imaging in the C-scan mode in conjunction with the amplitude of the reflected signal was used to measure flow rates of an epoxy resin film penetrating through the thickness of single layers of woven carbon fabric. Assemblies, comprised of a single layer of fabric and film, were vacuum-bagged and ultrasonically scanned in a water tank during impregnation at 50°C, 60°C, 70°C, and 80°C. Measured flow rates were plotted versus inverse viscosity to determine the permeability in the thin film, non-saturated system. The results demonstrated that ultrasonic imaging in the C-scan mode is an effective method of measuring z-direction resin flow through a single layer of fabric. The permeability values determined in this work were consistent with permeability values reported in the literature. Capillary flow was not observed at the temperatures and times required for pressurized flow to occur. The flow rate at 65°C was predicted from the linear plot of flow rate versus inverse viscosity. The effects of fabric architecture on through-thickness flow rates during impregnation of an epoxy resin film were measured by ultrasonic imaging. Multilayered laminates comprised of woven carbon fabrics and epoxy films (prepregs) were fabricated by vacuum-bagging. Ultrasonic imaging was performed in a heated water tank (65°C) during impregnation. Impregnation rates showed a strong dependence on fabric architecture, despite similar areal densities. Impregnation rates are directly affected by inter-tow spacing and tow nesting, which depend on fabric architecture, and are indirectly affected by areal densities. A new method of predicting resin infusion rates in prepreg and resin film infusion processes was proposed. The Stokes equation was used to derive an equation to predict the impregnation rate of laminates as a function of fabric architecture. Flow rate data previously measured by ultrasound was analyzed with the new equation and the Kozeny-Carman equation. A fiber

  3. Regulating emission of air pollutants for near-term relief from global warming

    Science.gov (United States)

    Ramanathan, V.; Xu, Y.

    2011-12-01

    The manmade greenhouse gases that are now blanketing the planet is thick enough to warm the system beyond the 20C threshold. Even with a targeted reduction in CO2 emission of 50% by 2050, we will still be adding more than 50 ppm of CO2 and add another 10C to the warming. Fortunately, there are still ways to contain the warming by reducing non-CO2 climate warmers (methane, lower atmosphere ozone, black carbon and HFCs), using available and field tested technologies. The major advantage of going for these 'low-hanging fruits' is that this approach will clean up the air and improve health and food security of south and east Asia, thus engaging developing nations more effectively in climate negotiations. These non-CO2 mitigation actions will have significant (beneficial) impacts on the chemistry, clouds and precipitation of the atmosphere and these have to be quantified adequately. For example, reducing black and organic carbon emissions (through cleaner cooking technologies in developing countries) will also lead to significant reductions in carbon monoxide, which is an ozone precursor. The institutional infrastructure for reducing non-CO2 climate warmers already exist and have a proven track record for successful climate mitigation.

  4. The Clean Air Act implementation and the coal industry: A regulator's perspective

    International Nuclear Information System (INIS)

    Rolka, D.W.

    1991-01-01

    Utility regulators are responsible for insuring that there is a sufficient supply of electricity to meet consumers needs at a reasonable price. The Pennsylvania Public Utility Commission Act (CAA) compliance strategies are effective at the lowest possible cost. Those potential compliance costs in Pennsylvania may exceed $3 billion by the end of the decade. This does not include worst case estimates of over $750 million per year in added operations and maintenance costs. In the face of these expenses, concerns such as jobs and the health of Pennsylvania's coal industry may carry little weight. The Commission cannot relieve companies of their responsibility for complying. Thus, in order to maintain its market among electric companies, coal will have to be competitive both in offering solutions to the emissions requirements of the CAA and in providing acceptable alternatives for future, new generating plants

  5. Performance of triple bagging hermetic technology for postharvest storage of cowpea grain in Niger

    KAUST Repository

    Baoua, Ibrahim B.; Margam, Venu; Amadou, Laouali; Murdock, Larry L.

    2012-01-01

    ) new 100 kg bags and (3) once-used 50 kg bags, all filled with naturally infested untreated cowpeas. In these PICS bags the O 2 levels within the bags initially fell to about 3 percent (v/v) while the CO 2 rose to nearly 5 percent (v/v). After five

  6. 76 FR 70965 - Polyethylene Retail Carrier Bags From Thailand: Correction to the Amended Final Results of...

    Science.gov (United States)

    2011-11-16

    ... Bags From Thailand: Correction to the Amended Final Results of Antidumping Duty Administrative Review... bags from Thailand for the period August 1, 2009, through July 31, 2010. The notice did not include the... bags from Thailand. See Polyethylene Retail Carrier Bags From Thailand: Amended Final Results of...

  7. The effects of four agrobotanical extracts and three types of bags on ...

    African Journals Online (AJOL)

    ... Shaki area of Oyo State, Nigeria and treated with extracts from Azadiractha indica (neem) leaf, Xylopia aethiopica(uda) pod, Occimum graticimum (nche anwu) leaf and Zingiber officinale (ginger) stem tuber. The storage bags were 0.05mm gauge polythene bags, 0.05mm gauge polythene-lined-jute bags and jute bags.

  8. Towards the methodological optimization of the moss bag technique in terms of contaminants concentrations and replicability values

    Science.gov (United States)

    Ares, A.; Fernández, J. A.; Carballeira, A.; Aboal, J. R.

    2014-09-01

    The moss bag technique is a simple and economical environmental monitoring tool used to monitor air quality. However, routine use of the method is not possible because the protocols involved have not yet been standardized. Some of the most variable methodological aspects include (i) selection of moss species, (ii) ratio of moss weight to surface area of the bag, (iii) duration of exposure, and (iv) height of exposure. In the present study, the best option for each of these aspects was selected on the basis of the mean concentrations and data replicability of Cd, Cu, Hg, Pb and Zn measured during at least two exposure periods in environments affected by different degrees of contamination. The optimal choices for the studied aspects were the following: (i) Sphagnum denticulatum, (ii) 5.68 mg of moss tissue for each cm-2 of bag surface, (iii) 8 weeks of exposure, and (iv) 4 m height of exposure. Duration of exposure and height of exposure accounted for most of the variability in the data. The aim of this methodological study was to provide data to help establish a standardized protocol that will enable use of the moss bag technique by public authorities.

  9. BOREAS TE-04 Branch Bag Data from Boreal Tree Species

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: Contains 1996 TE-04 data of branch bag studies of photosynthesis, respiration and stomatal conductance of boreal forest species using the open MPH-1000...

  10. Use of pliable bags in liquid scintillation counting

    International Nuclear Information System (INIS)

    Simonnet, G.; Jacquet, M.A.; Sharif, A.; Engler, R.

    1981-01-01

    Pliable plastic bags have been used to replace glass or plastic vials for liquid scintillation counting. The two major advantages of this method are the lower cost of the plastic bags and the fact that, per sample, the radioactive waste is significantly reduced. The following parameters have been checked: the impermeability of the bags to various scintillator mixtures and the fact that neither the irregular shape of the bags nor their position in the counting chamber had any effect on the results of the counting. The latter was also constant with time, at least over a period of 10 days. The technique has been used to count the radioactivity of 3 H-DNA precipitates prepared from bacteria and lymphocytes and deposited on filters impregnated with only 200 μl scintillator. It is a method that can be applied to the counting of any samples deposited on filters and insoluble in scintillator. (author)

  11. Fermion bag solutions to some unsolved sign problems

    Science.gov (United States)

    Li, Anyi; Chandrasekharan, Shailesh

    2012-03-01

    Some interesting lattice four-fermion models containing N flavors of staggered fermions with Z2 and U(1) chiral symmetries suffer from sign problems in the auxiliary field approach. Earlier calculations have either ignored these sign problems or have circumvented them by adding conjugate fermion fields which changes the model. In this talk we show that the recently proposed fermion bag approach solves these sign problems. The basic idea of the new approach is to collect unpaired fermionic degrees of freedom inside a fermion bag. A resummation of all fermion world lines inside the bag is then sufficient to solve the sign problems. The fermion bag approach provides new opportunities to solve in these ``unsolved'' four-fermion models in the chiral limit efficiently.

  12. 42 CFR 84.85 - Breathing bags; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... sufficient volume to prevent gas waste during exhalation and to provide an adequate reserve for inhalation. (b) Breathing bags shall be constructed of materials which are flexible and resistant to gasoline...

  13. In vitro digestibility of lucerne hay using bag method

    Directory of Open Access Journals (Sweden)

    constantin gavan

    2013-10-01

    Full Text Available A filter bag method was used for estimating apparent dry matter (DM digestibility, apparent digestible organic matter in DM, true DM digestibility, true digestible organic matter in DM and Digestibility of neutral detergent fibre. The forage sample analysed comprised tree plant parts (whole, leaf and stem of alfalfa (Medicago sativa, one degree of particle breakdown (1 mm sieve size at miliing and two field replicates at Agricultural Research and Developement Station (ARDS Șimnic-Craiova. Rumen fluid was used from two cannulated dairy cows. The use of filter bags can give acceptable results for the in vitro digestibility of forages. The escape of soluble matter from bags with samples high in solubles could influence the microbial population and hence increase cell wall degradation in bags with samples low in soluble matter, if  all are in the same incubation vessel.

  14. Hydrodynamical model based on a bag-like Lagrangian

    International Nuclear Information System (INIS)

    Chiu, C.B.; Lam, C.S.; Wang, K.H.

    1976-06-01

    Equations of motion of hydrodynamical model are derived from a bag-like Lagrangian by using the technique of information theory. Comments on the break-up of the system and on the properties of decay products are included

  15. Bag-model quantum chromodynamics for hyperons at low energy

    International Nuclear Information System (INIS)

    Weber, H.J.; Maslow, J.N.

    1980-01-01

    In a non-perturbative bag model framework, gluon exchange which mediates quark exchange scattering in conjunction with quark interchange is shown to be the basis of the OBE interactions of hyperons at low energy. (orig.)

  16. Transcriptional upregulation of BAG3 upon proteasome inhibition

    International Nuclear Information System (INIS)

    Wang Huaqin; Liu Haimei; Zhang Haiyan; Guan Yifu; Du Zhenxian

    2008-01-01

    Proteasome inhibitors exhibit antitumoral activity against malignancies of different histology. Emerging evidence indicates that antiapoptotic factors may also accumulate as a consequence of exposure to these drugs, thus it seems plausible that activation of survival signaling cascades might compromise their antitumoral effects. Bcl-2-associated athanogene (BAG) family proteins are characterized by their property of interaction with a variety of partners involved in modulating the proliferation/death balance, including heat shock proteins (HSP), Bcl-2, Raf-1. In this report, we demonstrated that BAG3 is a novel antiapoptotic molecule induced by proteasome inhibitors in various cancer cells at the transcriptional level. Moreover, we demonstrated that BAG3 knockdown by siRNA sensitized cancer cells to MG132-induced apoptosis. Taken together, our results suggest that BAG3 induction might represents as an unwanted molecular consequence of utilizing proteasome inhibitors to combat tumors

  17. Properties of hybrid stars in an extended MIT bag model

    International Nuclear Information System (INIS)

    Bao Tmurbagan; Liu Guangzhou; Zhu Mingfeng

    2009-01-01

    The properties of hybrid stars are investigated in the framework of the relativistic mean field theory (RMFT) and an MIT bag model with density-dependent bag constant to describe the hadron phase (HP) and quark phase (QP), respectively. We find that the density-dependent B(ρ) decreases with baryon density ρ; this decrement makes the strange quark matter become more energetically favorable than ever; which makes the threshold densities of the hadron-quark phase transition lower than those of the original bag constant case. In this case, the hyperon degrees of freedom can not be considered. As a result, the equations of state of a star in the mixed phase (MP) become softer whereas those in the QP become stiffer, and the radii of the star obviously decrease. This indicates that the extended MIT bag model is more suitable to describe hybrid stars with small radii. (authors)

  18. The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737.

    Science.gov (United States)

    Boiani, Mariana; Daniel, Cristina; Liu, Xueyuan; Hogarty, Michael D; Marnett, Lawrence J

    2013-03-08

    Members of the Bcl-2 family of proteins are important inhibitors of apoptosis in human cancer and are targets for novel anticancer agents such as the Bcl-2 antagonists, ABT-263 (Navitoclax), and its analog ABT-737. Unlike Bcl-2, Mcl-1 is not antagonized by ABT-263 or ABT-737 and is considered to be a major factor in resistance. Also, Mcl-1 exhibits differential regulation when compared with other Bcl-2 family members and is a target for anticancer drug discovery. Here, we demonstrate that BAG3, an Hsp70 co-chaperone, protects Mcl-1 from proteasomal degradation, thereby promoting its antiapoptotic activity. Using neuroblastoma cell lines, with a defined Bcl-2 family dependence, we found that BAG3 expression correlated with Mcl-1 dependence and ABT-737 resistance. RNA silencing of BAG3 led to a marked reduction in Mcl-1 protein levels and overcame ABT-737 resistance in Mcl-1-dependent cells. In ABT-737-resistant cells, Mcl-1 co-immunoprecipitated with BAG3, and loss of Mcl-1 after BAG3 silencing was prevented by proteasome inhibition. BAG3 and Mcl-1 were co-expressed in a panel of diverse cancer cell lines resistant to ABT-737. Silencing BAG3 reduced Mcl-1 protein levels and overcame ABT-737 resistance in several of the cell lines, including triple-negative breast cancer (MDA-MB231) and androgen receptor-negative prostate cancer (PC3) cells. These studies identify BAG3-mediated Mcl-1 stabilization as a potential target for cancer drug discovery.

  19. The Stress Protein BAG3 Stabilizes Mcl-1 Protein and Promotes Survival of Cancer Cells and Resistance to Antagonist ABT-737*

    Science.gov (United States)

    Boiani, Mariana; Daniel, Cristina; Liu, Xueyuan; Hogarty, Michael D.; Marnett, Lawrence J.

    2013-01-01

    Members of the Bcl-2 family of proteins are important inhibitors of apoptosis in human cancer and are targets for novel anticancer agents such as the Bcl-2 antagonists, ABT-263 (Navitoclax), and its analog ABT-737. Unlike Bcl-2, Mcl-1 is not antagonized by ABT-263 or ABT-737 and is considered to be a major factor in resistance. Also, Mcl-1 exhibits differential regulation when compared with other Bcl-2 family members and is a target for anticancer drug discovery. Here, we demonstrate that BAG3, an Hsp70 co-chaperone, protects Mcl-1 from proteasomal degradation, thereby promoting its antiapoptotic activity. Using neuroblastoma cell lines, with a defined Bcl-2 family dependence, we found that BAG3 expression correlated with Mcl-1 dependence and ABT-737 resistance. RNA silencing of BAG3 led to a marked reduction in Mcl-1 protein levels and overcame ABT-737 resistance in Mcl-1-dependent cells. In ABT-737-resistant cells, Mcl-1 co-immunoprecipitated with BAG3, and loss of Mcl-1 after BAG3 silencing was prevented by proteasome inhibition. BAG3 and Mcl-1 were co-expressed in a panel of diverse cancer cell lines resistant to ABT-737. Silencing BAG3 reduced Mcl-1 protein levels and overcame ABT-737 resistance in several of the cell lines, including triple-negative breast cancer (MDA-MB231) and androgen receptor-negative prostate cancer (PC3) cells. These studies identify BAG3-mediated Mcl-1 stabilization as a potential target for cancer drug discovery. PMID:23341456

  20. A Decade (almost) of Brown bag Seminars

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2018-01-01

    This collection of BB Seminar Series abstracts and titles is a celebration of sorts. The Center for Mobilities and Urban Studies (C-MUS) was established at Aalborg University in 2008. The 10th Year Anniversary conference to be held in August 2018 is a testament to this. It is not too much to say...... that during this decade C-MUS has grown to become an internationally well-recognized research center under the heading of the ‘new Mobilities turn’. However, a research center also need a daily life of mundane (but important) practices. This collection of abstracts takes you through the BB programs since...... series of BB presentations we get a sense of the academic debates and ‘matters of concern’ for the researchers in C-MUS. Moreover, this may also serve as an important pointer for the future. So next to presenting ‘old stories’ the report is an invitation to reflect upon the next decade of Brown Bag...

  1. Kluster Bag of Word Menggunakan Weka

    Directory of Open Access Journals (Sweden)

    Tari Mardiana

    2015-05-01

    Full Text Available Dalam bidang pengolahan bahasa alami dan sistem temu balik informasi, representasi sebuah data teks sangat penting untuk mendukung proses analisis data statistik di dalamnya. Data teks dengan bentuk tidak terstruktur dapat direpresentasikan secara sederhana menggunakan sekumpulan set kata yang disebut bag-of-words dan belum memiliki label atau kelas tertentu. Data unsupervised atau objek-objek yang belum memiliki label dapat dikelompokan menggunakan klustering berdasarkan kemiripan satu objek dengan objek lain. Artikel ini membahas perbandingan hasil pengelompokan unsupervised data menggunakan algoritma kluster yang tersedia pada tools Weka, yaitu SimpleKMeans, X-Means, dan Farthest First. SimpleKMeans dan XMeans digunakan untuk mengolah dataset dan mengelompokan berdasarkan jumlah kluster tetap yang digunakan, sedangkan Farthest First akan meletakan semua pusat kluster pada titik terjauh dari pusat kluster yang sudah ada untuk mengelompokan data. Dataset berasal dari UCI machine learning dengan menggunakan 3 koleksi data, yaitu Enron Email, NIPS Proceedings, dan Daily Kos Blog entries. Performa dataset diuji dengan berbagai masukan parameter yang berbeda meliputi jumlah kluster hingga evaluasi sum squared error (SSE, serta iterasi selama proses pengolahan data. Hasil penelitian diharapkan dapat dijadikan acuan untuk menentukan algoritma dan parameter yang sesuai untuk melakukan pengelompokan data yang tidak memiliki label.

  2. Regulating low-NOx and high-burnout deep-air-staging combustion under real-furnace conditions in a 600 MWe down-fired supercritical boiler by strengthening the staged-air effect.

    Science.gov (United States)

    Kuang, Min; Wang, Zhihua; Zhu, Yanqun; Ling, Zhongqian; Li, Zhengqi

    2014-10-21

    A 600 MW(e) down-fired pulverized-coal supercritical boiler, which was equipped with a deep-air-staging combustion system for reducing the particularly high NOx emissions, suffered from the well-accepted contradiction between low NOx emissions and high carbon in fly ash, in addition to excessively high gas temperatures in the hopper that jeopardized the boiler's safe operations. Previous results uncovered that under low-NOx conditions, strengthening the staged-air effect by decreasing the staged-air angle and simultaneously increasing the staged-air damper opening alleviated the aforementioned problems to some extent. To establish low-NOx and high-burnout circumstances and control the aforementioned hopper temperatures, a further staged-air retrofit with horizontally redirecting staged air through an enlarged staged-air slot area was performed to greatly strengthen the staged-air effect. Full-load industrial-size measurements were performed to confirm the availability of this retrofit. The present data were compared with those published results before the retrofit. High NOx emissions, low carbon in fly ah, and high hopper temperatures (i.e., levels of 1036 mg/m(3) at 6% O2, 3.72%, and about 1300 °C, respectively) appeared under the original conditions with the staged-air angle of 45° and without overfire air (OFA) application. Applying OFA and reducing the angle to 20° achieved an apparent NOx reduction and a moderate hopper temperature decrease while a sharp increase in carbon in fly ash (i.e., levels of 878 mg/m(3) at 6% O2, about 1200 °C, and 9.81%, respectively). Fortunately, the present staged-air retrofit was confirmed to be applicable in regulating low-NOx, high-burnout, and low hopper temperature circumstances (i.e., levels of 867 mg/m(3) at 6% O2, 5.40%, and about 1100 °C, respectively).

  3. The use of filtered bags to increase waste payload capacity

    International Nuclear Information System (INIS)

    Dustin, D.F.; Thorp, D.T.; Rivera, M.A.

    1998-01-01

    For the past few years, the Department of Energy has favored the direct disposal of low plutonium content residue materials from Rocky Flats rather than engage in expensive and time consuming plutonium recovery operations. One impediment to direct disposal has been the wattage limit imposed by the Waste Isolation Pilot Plant on hydrogenous materials such as combustibles and sludges. The issue of concern is the radiolytic generation and accumulation of hydrogen and other explosive gases in waste containers. The wattage limits that existed through 1996 restricted the amount of plutonium bearing hydrogenous materials that could be packaged in a WIPP bound waste drum to only a fraction of the capacity of a drum. Typically, only about one kilogram of combustible residue could be packaged in a waste drum before the wattage limit was exceeded resulting in an excessively large number of drums to be procured, stored, shipped, and interred. The Rocky Flats Environmental Technology Site has initiated the use of filtered plastic bags (called bag-out bags) used to remove transuranic waste materials from glove box lines. The bags contain small, disk like HEPA filters which are effective in containing radioactively contaminated particulate material but allow for the diffusion of hydrogen gas. Used in conjunction with filtered 55 gallon drums, filtered bag-out bags were pursued as a means to increase the allowable wattage limits for selected residue materials. In February 1997, the Nuclear Regulatory Commission approved the use of filtered bag-out bags for transuranic waste materials destined for WIPP. The concomitant increase in wattage limits now allows for approximately four times the payload per waste drum for wattage limited materials

  4. Comment on bag models with spontaneously broken color symmetry

    International Nuclear Information System (INIS)

    Jandel, M.

    1985-01-01

    A recently suggested field-theoretic bag model, where gluons are confined via a Higgs mechanism, is discussed. It is found that the proposed model creates gluon boundary conditions that break global SU/sub c/(3) invariance. A modified scheme that removes this anomaly is suggested. However, some severe generic problems remain. Examples are the lack of a suppression mechanism for states with open color and the large surface energy of the bag states

  5. Bagworm bags as portable armour against invertebrate predators

    OpenAIRE

    Sugiura, Shinji

    2016-01-01

    Some animals have evolved the use of environmental materials as “portable armour” against natural enemies. Portable bags that bagworm larvae (Lepidoptera: Psychidae) construct using their own silk and plant parts are generally believed to play an important role as a physical barrier against natural enemies. However, no experimental studies have tested the importance of bags as portable armour against predators. To clarify the defensive function, I studied the bagworm Eumeta minuscula and a po...

  6. Study of the suitability of DUO plastic bags for the storage of dynamites.

    Science.gov (United States)

    Sáiz, Jorge; Ferrando, José-Luis; Atoche, Juan-Carlos; García-Ruiz, Carmen

    2013-10-10

    A comparative study on the retentiveness of two plastic bags (DUO and Royal Pack) has been carried out by gas chromatography with mass spectrometry detection. Two types of dynamites were packed in both plastic bags. The bags were placed into glass jars and headspace analyses were performed over 11 weeks to detect whether the volatile constituents of the dynamites were released from the bags. DUO plastic bags showed much better retentiveness than Royal Pack plastic bags. Ethylene glycol dinitrate (EGDN) was quickly detected in the headspace of the glass jars containing Royal Pack plastic bags after 1 week of storage. On the contrary, only a weak signal of EGDN, which was not detectable in the total ion chromatogram, was detected after 11 weeks of storage. Moreover, DUO plastic bags have shown less background signals than the Royal Pack bags, being the former bags much more suitable for the storage of dynamites. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  7. Regulation of CO2 Air Sea Fluxes by Sediments in the North Sea

    Science.gov (United States)

    Burt, William; Thomas, Helmuth; Hagens, Mathilde; Brenner, Heiko; Pätsch, Johannes; Clargo, Nicola; Salt, Lesley

    2016-04-01

    A multi-tracer approach is applied to assess the impact of boundary fluxes (e.g. benthic input from sediments or lateral inputs from the coastline) on the acid-base buffering capacity, and overall biogeochemistry, of the North Sea. Analyses of both basin-wide observations in the North Sea and transects through tidal basins at the North-Frisian coastline, reveal that surface distributions of the δ13C signature of dissolved inorganic carbon (DIC) are predominantly controlled by a balance between biological production and respiration. In particular, variability in metabolic DIC throughout stations in the well-mixed southern North Sea indicates the presence of an external carbon source, which is traced to the European continental coastline using naturally-occurring radium isotopes (224Ra and 228Ra). 228Ra is also shown to be a highly effective tracer of North Sea total alkalinity (AT) compared to the more conventional use of salinity. Coastal inputs of metabolic DIC and AT are calculated on a basin-wide scale, and ratios of these inputs suggest denitrification as a primary metabolic pathway for their formation. The AT input paralleling the metabolic DIC release prevents a significant decline in pH as compared to aerobic (i.e. unbuffered) release of metabolic DIC. Finally, long-term pH trends mimic those of riverine nitrate loading, highlighting the importance of coastal AT production via denitrification in regulating pH in the southern North Sea.

  8. Efficient air pollution regulation of coal-fired power in China

    Science.gov (United States)

    Feng, Therese

    This dissertation evaluates monetary external costs of electricity generation in the People's Republic of China and implications for efficient pollution control policy. It presents an integrated assessment of environmental damages of air emissions of a representative new coal-fired plant in urban areas of north and south China. The simulation evaluates the nature and magnitude of damages in China, transboundary effects in Japan and Korea, and global greenhouse gas warming impacts. The valuation is used to identify efficient abatement policy for Chinese plants over time; evaluate benefits of differentiated policies; and consider the importance of dynamic policy. Potential annual damages of operating a 600-MW power plant without controls in China today would be 43-45 million (U.S. 1995). Annual local damages of 37-40 million far exceed transboundary or greenhouse gas damages (1.4 million and $4.6 million respectively). The largest component of damages is the risk of human mortality and chronic morbidity from long-term exposure to fine particles. Efficient pollution control minimizes the sum of abatement costs and residual unabated damages. Because monetary damages reflect sufferers' willingness to pay to avoid environmental risks, the choice of efficient controls is fundamentally tied to societal values and preferences. The optimal path for Chinese abatement moves from modest dispersion measures at present to combined dispersion and emission controls approaching those of current-day United States, by 2050. The inclusion of transboundary and greenhouse damages does not substantively alter local policies. Welfare benefits are gained by differentiating abatement policy by pollutant, meteorological parameters, and by population density. An analysis of optimal one-time investment in abatement for a plant in a growing economy suggests that some investment is optimal at all incomes but no single level of abatement is suitable for all economies. Forward-looking policy

  9. Review on the Influences of Bagging Treatment on Pesticide Residue in Fruits

    OpenAIRE

    ZHAO Xiao-yun; XIE De-fang

    2018-01-01

    At present, bagging technology has been widely applicated in fruit cultivation. Impact of bagging treatment on the pesticide residues have different results. On the basis of existing achievements, this paper systematically analyzed the influence of different bagging treatments on pesticide residues:such as different ways of applying pesticide, pesticide concentration, number of applying pesticide; bagging materials, bagged layer; the type of pesticide(systemic pesticide, nonendoscopic pestici...

  10. Fermion bag approach to the sign problem in strongly coupled lattice QED with Wilson fermions

    OpenAIRE

    Chandrasekharan, Shailesh; Li, Anyi

    2010-01-01

    We explore the sign problem in strongly coupled lattice QED with one flavor of Wilson fermions in four dimensions using the fermion bag formulation. We construct rules to compute the weight of a fermion bag and show that even though the fermions are confined into bosons, fermion bags with negative weights do exist. By classifying fermion bags as either simple or complex, we find numerical evidence that complex bags with positive and negative weights come with almost equal probabilities and th...

  11. Extended Stability of Epinephrine Hydrochloride Injection in Polyvinyl Chloride Bags Stored in Amber Ultraviolet Light-Blocking Bags.

    Science.gov (United States)

    Van Matre, Edward T; Ho, Kang C; Lyda, Clark; Fullmer, Beth A; Oldland, Alan R; Kiser, Tyree H

    2017-09-01

    Objective: The objective of this study was to evaluate the stability of epinephrine hydrochloride in 0.9% sodium chloride in polyvinyl chloride bags for up to 60 days. Methods: Dilutions of epinephrine hydrochloride to concentrations of 16 and 64 µg/mL were performed under aseptic conditions. The bags were then placed into ultraviolet light-blocking bags and stored at room temperature (23°C-25°C) or under refrigeration (3°C-5°C). Three samples of each preparation and storage environment were analyzed on days 0, 30, 45, and 60. Physical stability was performed by visual examination. The pH was assessed at baseline and upon final degradation evaluation. Sterility of the samples was not assessed. Chemical stability of epinephrine hydrochloride was evaluated using high-performance liquid chromatography. To determine the stability-indicating nature of the assay, degradation 12 months following preparation was evaluated. Samples were considered stable if there was less than 10% degradation of the initial concentration. Results: Epinephrine hydrochloride diluted to 16 and 64 µg/mL with 0.9% sodium chloride injection and stored in amber ultraviolet light-blocking bags was physically stable throughout the study. No precipitation was observed. At days 30 and 45, all bags had less than 10% degradation. At day 60, all refrigerated bags had less than 10% degradation. Overall, the mean concentration of all measurements demonstrated less than 10% degradation at 60 days at room temperature and under refrigeration. Conclusion: Epinephrine hydrochloride diluted to 16 and 64 µg/mL with 0.9% sodium chloride injection in polyvinyl chloride bags stored in amber ultraviolet light-blocking bags was stable up to 45 days at room temperature and up to 60 days under refrigeration.

  12. A validation study of new cryopreservation bags for implementation in a blood and marrow transplant laboratory.

    Science.gov (United States)

    Pomper, Gregory J; Wilson, Emily; Isom, Scott; Hurd, David D

    2011-06-01

    A new cryopreservation bag for hematopoietic cell transplantation requires validation as a safe alternative to the bag currently being used in the laboratory. The new bag was validated using both laboratory and clinical criteria. Laboratory validation proceeded using paired samples of mononuclear cells processed using standard procedures. Cells cryopreserved in the new and old bags were compared for viability, cell counts, CD34 enumeration, colony-forming unit assays, and bag integrity. After completion of laboratory investigations, engraftment with the new bags was followed and compared to historical engraftment using the old bags. There were no significant differences between the old and new bags detected using laboratory studies. Bag integrity was equivalent. The validation data suggested impaired cell function after cryopreservation in the new bags, but there were no significant differences in engraftment potential using either material. Days to engraftment was longer using the new bags, but statistical analysis revealed an association with CD34 dose and not with cryopreservation bag type. The new bags were noninferior to the old bags. A change in cryopreservation bag type may appear to affect cell function and potentially affect engraftment. Multiple analyses may be needed to understand the effect of cell processing changes. © 2010 American Association of Blood Banks.

  13. Filtration of Oil-furnace Carbon Black Dust Particles from the Tail Gases by Filter Bags With PTFE Membrane

    Directory of Open Access Journals (Sweden)

    Čuzela, D.

    2010-01-01

    Full Text Available During the industrial production of oil furnace carbon black, tail gases containing oil-furnace carbon black dust particles are emitted to the atmosphere. In the carbon black plant, Petrokemija d. d., there are six exhaust stacks for tail gases. Each of them has installed process equipment for cleaning tail gases. Efficiency of cleaning mainly depends on equipment construction and cleaning technology. The vicinity of the town, quality of the air in the region of Kutina, regarding floating particles PM10, and corporate responsibility for further enviromental improvement, imposes development of new methods that will decrease the emmision of oil-furnace carbon black dust particles in the air. Combining centrifugal percipitator and filter, special construction of cyclofilter for filtration of oil-furnace carbon black dust particles from tail gases by using PTFE (polytetrafluoroethylene membrane filter bags, was designed. Developed filtration technique provides η = 99.9 % efficiency of filtration. Construction part of the filter contains the newest generation of PTFE membrane filter bags with the ability of jet pulse cleaning. Using the PTFE membrane filter bags technology, filtration efficiency for oil-furnace carbon black dust particles in tail gases of maximum γ=5mgm-3can be achieved. The filtration efficiency was monitored continuously measuring the concentration of the oil-furnace carbon black dust particles in the tail gases with the help of in situ electronic probe. The accomplished filtration technology is the base for the installation of the PTFE membrane filter bags in the main operation filters which will provide better protection of the air in the town of Kutina against floating particles PM10.

  14. Move towards bag filter units in kiln dedusting; Vers l'utilisation de filtres a manches en four a ciment

    Energy Technology Data Exchange (ETDEWEB)

    Schobesberger, M.

    2000-02-01

    Dedusting of kiln gases has become a major concern for cement companies worldwide due to the more and more stringent environmental standards. This short paper draws out an overview of the recent trends in dedusting techniques using bag filters. A comparison is made between different factories and their experience in the use of bag filters made of different materials or used in different operating conditions. The lifetime of these filters is the main problem to deal with and depends on various factors such as the the material used, the air to cloth ratio, the flow rate, temperature, and moisture of the flue gases. (J.S.)

  15. Green spaces are not all the same for the provision of air purification and climate regulation services: The case of urban parks.

    Science.gov (United States)

    Vieira, Joana; Matos, Paula; Mexia, Teresa; Silva, Patrícia; Lopes, Nuno; Freitas, Catarina; Correia, Otília; Santos-Reis, Margarida; Branquinho, Cristina; Pinho, Pedro

    2018-01-01

    The growing human population concentrated in urban areas lead to the increase of road traffic and artificial areas, consequently enhancing air pollution and urban heat island effects, among others. These environmental changes affect citizen's health, causing a high number of premature deaths, with considerable social and economic costs. Nature-based solutions are essential to ameliorate those impacts in urban areas. While the mere presence of urban green spaces is pointed as an overarching solution, the relative importance of specific vegetation structure, composition and management to improve the ecosystem services of air purification and climate regulation are overlooked. This avoids the establishment of optimized planning and management procedures for urban green spaces with high spatial resolution and detail. Our aim was to understand the relative contribution of vegetation structure, composition and management for the provision of ecosystem services of air purification and climate regulation in urban green spaces, in particular the case of urban parks. This work was done in a large urban park with different types of vegetation surrounded by urban areas. As indicators of microclimatic effects and of air pollution levels we selected different metrics: lichen diversity and pollutants accumulation in lichens. Among lichen diversity, functional traits related to nutrient and water requirements were used as surrogates of the capacity of vegetation to filter air pollution and to regulate climate, and provide air purification and climate regulation ecosystem services, respectively. This was also obtained with very high spatial resolution which allows detailed spatial planning for optimization of ecosystem services. We found that vegetation type characterized by a more complex structure (trees, shrubs and herbaceous layers) and by the absence of management (pruning, irrigation and fertilization) had a higher capacity to provide the ecosystems services of air

  16. Spatiotemporal distribution of airborne elements monitored with the moss bags technique in the Greater Thriasion Plain, Attica, Greece.

    Science.gov (United States)

    Saitanis, C J; Frontasyeva, M V; Steinnes, E; Palmer, M W; Ostrovnaya, T M; Gundorina, S F

    2013-01-01

    The well-known moss bags technique was applied in the heavily polluted Thriasion Plain region, Attica, Greece, in order to study the spatiotemporal distribution, in the atmosphere, of the following 32 elements: Na, Al, Cl, Ca, Sc, Ti, V, Cr, Mn, Fe, Ni, Co, Zn, As, Se, Br, Sr, Mo, Sb, I, Ba, La, Ce, Sm, Tb, Dy, Yb, Hf, Ta, Hg, Th, and U. The moss bags were constituted of Sphagnum girgensohnii materials. The bags were exposed to ambient air in a network of 12 monitoring stations scattered throughout the monitoring area. In order to explore the temporal variation of the pollutants, four sets of moss bags were exposed for 3, 6, 9, and 12 months. Instrumental neutral activation analysis was used for the determinations of the elements. The data were analyzed using the Pearson correlations, the partial redundancy analysis, and the biplot statistical methods. Some pairs of elements were highly correlated indicating a probable common source of origin. The levels of the measured pollutants were unevenly distributed throughout the area and different pollutants exhibited different spatial patterns. In general, higher loads were observed in the stations close to and within the industrial zone. Most of the measured elements (e.g., Al, Ca, Ni, I, Zn, Cr, and As) exhibited a monotonic accumulation trend over time. Some elements exhibited different dynamics. The elements Mn, Mo, and Hg showed a decreasing trend, probably due to leaching and/or volatilization processes over time. Na and Br initially showed an increasing trend during the winter and early spring periods but decreased drastically during the late warm period. The results further suggest that the moss bags technique would be considered valuable for the majority of elements but should be used with caution in the cases of elements vulnerable to leaching and/or volatilization. It also suggests that the timing and the duration of the exposure of moss materials should be considered in the interpretation of the results.

  17. Burns From Hot Wheat Bags: A Public Safety Issue

    Science.gov (United States)

    Collins, Anna; Amprayil, Mathew; Solanki, Nicholas S.; Greenwood, John Edward

    2011-01-01

    Introduction: Wheat bags are therapeutic devices that are heated in microwaves and commonly used to provide relief from muscle and joint pain. The Royal Adelaide Hospital Burns Unit has observed a number of patients with significant burn injuries resulting from their use. Despite their dangers, the products come with limited safety information. Methods: Data were collected from the Burns Unit database for all patients admitted with burns due to hot wheat bags from 2004 to 2009. This was analyzed to determine the severity of the burn injury and identify any predisposing factors. An experimental study was performed to measure the temperature of wheat bags when heated to determine their potential for causing thermal injury. Results: 11 patients were admitted with burns due to hot wheat bags. The median age was 52 years and the mean total body surface area was 1.1%. All burns were either deep dermal (45.5%) or full thickness (54.5%). Ten patients required operative management. Predisposing factors (eg, neuropathy) to thermal injury were identified in 7 patients. The experimental study showed that hot wheat bags reached temperatures of 57.3°C (135.1°F) when heated according to instructions, 63.3°C (145.9°F) in a 1000 W microwave and 69.6°C (157.3°F) on reheating. Conclusions: Hot wheat bags cause serious burn injury. When heated improperly, they can reach temperatures high enough to cause epidermal necrosis in a short period of time. Patients with impaired temperature sensation are particularly at risk. There should be greater public awareness of the dangers of wheat bag use and more specific safety warnings on the products. PMID:21915357

  18. BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells.

    Science.gov (United States)

    Das, Chandan Kanta; Linder, Benedikt; Bonn, Florian; Rothweiler, Florian; Dikic, Ivan; Michaelis, Martin; Cinatl, Jindrich; Mandal, Mahitosh; Kögel, Donat

    2018-03-01

    Target-specific treatment modalities are currently not available for triple-negative breast cancer (TNBC), and acquired chemotherapy resistance is a primary obstacle for the treatment of these tumors. Here we employed derivatives of BT-549 and MDA-MB-468 TNBC cell lines that were adapted to grow in the presence of either 5-Fluorouracil, Doxorubicin or Docetaxel in an aim to identify molecular pathways involved in the adaptation to drug-induced cell killing. All six drug-adapted BT-549 and MDA-MB-468 cell lines displayed cross resistance to chemotherapy and decreased apoptosis sensitivity. Expression of the anti-apoptotic co-chaperone BAG3 was notably enhanced in two thirds (4/6) of the six resistant lines simultaneously with higher expression of HSP70 in comparison to parental controls. Doxorubicin-resistant BT-549 (BT-549 r DOX 20 ) and 5-Fluorouracil-resistant MDA-MB-468 (MDA-MB-468 r 5-FU 2000 ) cells were chosen for further analysis with the autophagy inhibitor Bafilomycin A1 and lentiviral depletion of ATG5, indicating that enhanced cytoprotective autophagy partially contributes to increased drug resistance and cell survival. Stable lentiviral BAG3 depletion was associated with a robust down-regulation of Mcl-1, Bcl-2 and Bcl-xL, restoration of drug-induced apoptosis and reduced cell adhesion in these cells, and these death-sensitizing effects could be mimicked with the BAG3/Hsp70 interaction inhibitor YM-1 and by KRIBB11, a selective transcriptional inhibitor of HSF-1. Furthermore, BAG3 depletion was able to revert the EMT-like transcriptional changes observed in BT-549 r DOX 20 and MDA-MB-468 r 5-FU 2000 cells. In summary, genetic and pharmacological interference with BAG3 is capable to resensitize TNBC cells to treatment, underscoring its relevance for cell death resistance and as a target to overcome therapy resistance of breast cancer. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Radon in air calibration procedure: A primary method

    International Nuclear Information System (INIS)

    Lucas, H.F.; Markun, F.

    1988-01-01

    A procedure has been developed for preparing 3- to 9-iota volumes of air under natural conditions with a known concentration of /sup 222/Rn to be used for calibrating radon systems. Air is passed into a plastic bag through a standard /sup 226/Ra solution (prepared by the U.S. National Bureau of Standards) contained in an emanation flask. This plastic bag retains /sup 222/Rn with little loss into or through the bag walls. The mean ratios of the /sup 222/Rn in the air at 2 and 7 days after filling to that immediately after filling were -.992 +- 0.006 and 0.969 +- 0.008, which suggests a rate of radon loss into the bag of 0.4 +- 0.1%/day

  20. Improved bag models of P-wave baryons

    International Nuclear Information System (INIS)

    Wang Fan; Wong Chunwa

    1988-01-01

    Problems in two previous bag-model calculations of P-wave baryon states are pointed out. The two-body matrix elements used in one of these models, the Myhrer-Wroldsen bag model, have now been revised and corrected by Myhrer, Umino and Wroldsen. We use their corrected matrix elements to construct simple bag models in which baryon masses are stabilized against collapse by using a finite pion size. We find that baryon masses in both ground and excited states can be fitted with the same model parameters. Models with small-bag baryons of the type proposed by Brown and Rho are then obtained. Typical bag radii are 0.5 fm for N, 0.6 fm for Δ and 0.7 fm for P-wave nonstrange baryons. In these models, the mixing angles are still unsatisfactory, while inadequacy in the treatment of center-of-mass motion found in an earlier paper persists. These results are briefly discussed. especially in connection with skyrmion models. (orig.)

  1. Maximum Mass of Hybrid Stars in the Quark Bag Model

    Science.gov (United States)

    Alaverdyan, G. B.; Vartanyan, Yu. L.

    2017-12-01

    The effect of model parameters in the equation of state for quark matter on the magnitude of the maximum mass of hybrid stars is examined. Quark matter is described in terms of the extended MIT bag model including corrections for one-gluon exchange. For nucleon matter in the range of densities corresponding to the phase transition, a relativistic equation of state is used that is calculated with two-particle correlations taken into account based on using the Bonn meson-exchange potential. The Maxwell construction is used to calculate the characteristics of the first order phase transition and it is shown that for a fixed value of the strong interaction constant αs, the baryon concentrations of the coexisting phases grow monotonically as the bag constant B increases. It is shown that for a fixed value of the strong interaction constant αs, the maximum mass of a hybrid star increases as the bag constant B decreases. For a given value of the bag parameter B, the maximum mass rises as the strong interaction constant αs increases. It is shown that the configurations of hybrid stars with maximum masses equal to or exceeding the mass of the currently known most massive pulsar are possible for values of the strong interaction constant αs > 0.6 and sufficiently low values of the bag constant.

  2. Performance of triple bagging hermetic technology for postharvest storage of cowpea grain in Niger

    KAUST Repository

    Baoua, Ibrahim B.

    2012-10-01

    Triple bagging technology for protecting postharvest cowpea grain from losses to the bruchid, Callosobruchus maculatus Fabricius (Coleoptera: Chrysomelidae: Bruchinae) is currently being adopted on a fairly large scale in ten West and Central African countries, including Niger. The triple bag consists of two inner high-density polyethylene bags acting as oxygen barriers, which in turn are encased in an outer woven polypropylene bag that serves primarily for mechanical strength. These hermetic bags, available in either 50 or 100 kg capacity, are called Purdue Improved Cowpea Storage (PICS) bags. Adoption of PICS technology in West and Central Africa has been driven by its effectiveness, simplicity, low cost, durability, and manufacture within the region. From surveys on adoption we discovered that farmers have begun to re-use bags they had used the previous year or even the previous two years. In the present study, we compared the performance of three different types of PICS bags: (1) new 50 kg (2) new 100 kg bags and (3) once-used 50 kg bags, all filled with naturally infested untreated cowpeas. In these PICS bags the O 2 levels within the bags initially fell to about 3 percent (v/v) while the CO 2 rose to nearly 5 percent (v/v). After five months of storage, new and used 50 kg bags and new 100 kg bags preserved the grain equally well. There were greatly reduced numbers of adults and larvae in the PICS bags versus the controls, which consisted of grain stored in single layer woven bags. The proportion of grain having C. maculatus emergence holes after five months of storage in PICS bags was little changed from that found when the grain was first put into the bags. The PICS technology is practical and useful in Sahelian conditions and can contribute to improved farmers\\' incomes as well as increase availability of high quality, insecticide-free cowpea grain as food. © 2012 Elsevier Ltd.

  3. Upregulation of BAG3 with apoptotic and autophagic activities in maggot extract‑promoted rat skin wound healing.

    Science.gov (United States)

    Dong, Jian-Li; Dong, Hai-Cao; Yang, Liang; Qiu, Zhe-Wen; Liu, Jia; Li, Hong; Zhong, Li-Xia; Song, Xue; Zhang, Peng; Li, Pei-Nan; Zheng, Lian-Jie

    2018-03-01

    Maggot extract (ME) accelerates rat skin wound healing, however its effect on cell maintenance in wound tissues remains unclear. B‑cell lymphoma (Bcl) 2‑associated athanogene (BAG)3 inhibits apoptosis and promotes autophagy by associating with Bcl‑2 or Beclin 1. Bcl‑2, the downstream effector of signal transducer and activator of transcription 3 signaling, is enhanced in ME‑treated wound tissues, which may reinforce the Bcl‑2 anti‑apoptotic activity and/or cooperate with Beclin 1 to regulate autophagy during wound healing. The present study investigated expression levels of BAG3, Bcl‑2, Beclin 1 and light chain (LC)3 levels in rat skin wound tissues in the presence and absence of ME treatment. The results revealed frequent TUNEL‑negative cell death in the wound tissues in the early three days following injury, irrespective to ME treatment. TUNEL‑positive cells appeared in the wound tissues following 4 days of injury and 150 µg/ml ME efficiently reduced apoptotic rate and enhanced BAG3 and Bcl‑2 expression. Elevated Beclin 1 and LC3 levels and an increased LC3 II ratio were revealed in the ME‑treated tissues during the wound healing. The results of the present study demonstrate the anti‑apoptotic effects of BAG3 and Bcl‑2 in ME‑promoted wound healing. Beclin 1/LC3 mediated autophagy may be favorable in maintaining cell survival in the damaged tissues and ME‑upregulated BAG3 may enhance its activity.

  4. Dust extraction from gas in cement kilns, using bag filters; Depoussierage des gaz de four cimentier par les filtres a manches

    Energy Technology Data Exchange (ETDEWEB)

    Harmegnies, M. [CALCIA, 78 - Guerville (France). Direction Technique

    1996-12-31

    After a review of regulations concerning cement plant emissions, the two main cement production techniques (dry and semi-dry processes) are described and the electrostatic and bag filter de-dusting techniques are compared. Examples of pilot applications of these techniques in two French cement plants are presented and operating results (performances, transient procedures, costs) are discussed

  5. Multipurpose Cargo Transfer Bags fro Reducing Exploration Mission Logistics

    Science.gov (United States)

    Baccus, Shelley; Broyan, James Lee, Jr.; Borrego, Melissa

    2016-01-01

    The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) division is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag (CTB), the common logistics carrying bag for the International Space Station (ISS). After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unfolded into a flat panel for reuse. Concepts and potential benefits for various MCTB applications will be discussed including partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing. Acoustic MCTBs are currently in use on ISS to reduce the noise generated by the T2 treadmill, which reaches the hazard limit at high speeds. The development of the AMCTB included identification of keep out zones, acoustic properties, deployment considerations, and structural testing. Features developed for these considerations are applicable to MCTBs for all crew outfitting applications.

  6. Reducing Mission Logistics with Multipurpose Cargo Transfer Bags

    Science.gov (United States)

    Baccus, Shelley; Broyan, James Lee, Jr.; Borrego, Melissa

    2016-01-01

    The Logistics Reduction (LR) project within Advanced Exploration Systems (AES) is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag (CTB), the common logistics carrying bag for the International Space Station (ISS). After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unfolded into a flat panel for reuse. Concepts and potential benefits for various MCTB applications will be discussed including partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing. Acoustic MCTBs are currently in use on ISS to reduce the noise generated by the T2 treadmill, which reaches the hazard limit at high speeds. The development of the AMCTB included identification of keep-out zones, acoustic properties, deployment considerations, and structural testing. Features developed for these considerations are applicable to MCTBs for all crew outfitting applications.

  7. Are the N and Δ deformed MIT bags

    International Nuclear Information System (INIS)

    Clement, G.; Maamache, M.

    1985-01-01

    The influence of the one-gluon exchange interaction, zero-point energy, and centre-of-mass correction, on the deformation of the nucleon and Δ bags, is studied in the MIT bag model. If the sharp MIT boundary conditions are taken seriously, the strong dependence of the zero-point energy on the deformation leads to the collapse of the N and Δ bags for realistic values of the strong fine structure constant α/sub S/. If on the other hand the zero-point energy is ignored altogether, then the nucleon, spherical for α/sub S/ 3.25, while the Δ is always prolate. The various predictions of the model are, for α/sub S/> or approx. =3.25, consistent with experiment, except for the proton magnetic moment which is only about 40% of the experimental value

  8. Asphyxial suicide by inhalation of chloroform inside a plastic bag.

    Science.gov (United States)

    Zorro, Andres Rodriguez

    2014-01-01

    Asphyxia suicide by placing a plastic bag over the head in addition with inhalation of gases or use of sedative substances is an unusual method of committing suicide, but frequently referenced by right to die groups in the Internet. This article reports 2 suicides in which chloroform was used to induce unconsciousness and subsequent asphyxia by placing the head in a plastic bag. Case histories of 2 males, ages 23 and 28, are described with special emphasis on characteristics death related to suffocation using plastic bags and chloroform. The final remarkable point in both cases is that the victims previously searched the WEB for instructions of suicide methods. The importance of the phenomenon of misuse of Internet by young people who commit suicide is stressed. Copyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  9. Optimising nitrogen elimination performance in an urban waste water treatment plant by regulating the air supply.; Optimizacion del rendimiento de eliminacion de nitrogeno en una EDAR urbana mediante la regulacion de la aportacion de aire

    Energy Technology Data Exchange (ETDEWEB)

    Filter, M.; Rodriguez-Roda, I.; Colprin, J.; Poch, M.

    2002-07-01

    This study sought to optimise the performance of the biological elimination of nitrogen in an urban waste water treatment plant that was not designed to eliminate nutrients. Previous studies had indicated that regulating the air flow could have a decisive effects in guaranteeing the existence of aerobic and anoxic areas in the biological reactor, which are necessary conditions for the nitrification/denitrification process to take place. The air flow was regulated manually in accordance with the monitoring of the dissolved oxygen content and the daily analyses of nitrogen in the effluent. The results show that during the seven months of the study, nitrogen elimination performance was high and nitrogen in the effluent was below the legal limit at all times. (Author) 5 refs.

  10. Performance of PICS bags under extreme conditions in the sahel zone of Niger.

    Science.gov (United States)

    Baoua, Ibrahim B; Bakoye, Ousmane; Amadou, Laouali; Murdock, Larry L; Baributsa, Dieudonne

    2018-03-01

    Experiments in Niger assessed whether extreme environmental conditions including sunlight exposure affect the performance of triple-layer PICS bags in protecting cowpea grain against bruchids. Sets of PICS bags and woven polypropylene bags as controls containing 50 kg of naturally infested cowpea grain were held in the laboratory or outside with sun exposure for four and one-half months. PICS bags held either inside or outside exhibited no significant increase in insect damage and no loss in weight after 4.5 months of storage compared to the initial values. By contrast, woven bags stored inside or outside side by side with PICS bags showed several-fold increases in insects present in or on the grain and significant losses in grain weight. Grain stored inside in PICS bags showed no reduction in germination versus the initial value but there was a small but significant drop in germination of grain in PICS bags held outside (7.6%). Germination rates dropped substantially more in grain stored in woven bags inside (16.1%) and still more in woven bags stored outside (60%). PICS bags held inside and outside retained their ability to maintain internal reduced levels of oxygen and elevated levels of carbon dioxide. Exposure to extreme environmental conditions degraded the external polypropylene outer layer of the PICS triple-layer bag. Even so, the internal layers of polyethylene were more slowly degraded. The effects of exposure to sunlight, temperature and humidity variation within the sealed bags are described.

  11. Deformed baryons: constituent quark model vs. bag model

    International Nuclear Information System (INIS)

    Iwamura, Y.; Nogami, Y.

    1985-01-01

    Recently Bhaduri et al. developed a nonrelativistic constituent quark model for deformed baryons. In that model the quarks move in a deformable mean field, and the deformation parameters are determined by minimizing the quark energy subject to the constraint of volume conservation. This constraint is an ad hoc assumption. It is shown that, starting with a bag model, a model similar to that of Bhaduri et al. can be constructed. The deformation parameters are determined by the pressure balance on the bag surface. There is, however, a distinct difference between the two models with respect to the state dependence of the ''volume''. Implications of this difference are discussed

  12. Pion-nucleon scattering in the chiral bag model

    International Nuclear Information System (INIS)

    Israilov, Z.Z.; Musakhanov, M.M.

    1981-01-01

    Pion-nucleon scattering in the (3.3) resonance region in the framework of chiral bag model(CBM) is considered. The effective Hamiltonian of πNΔ-system in the framework of the CBM contains πNN, πNΔ, πΔΔ interaction terms with the formfactor which is essentially dependent on the size and shape of the quark bag. The iteration of the Born graphs of this model provides successful description of the (3.3) and (3.1) scattering where the values of the parameters agree with CBM [ru

  13. Linearized theory of inhomogeneous multiple 'water-bag' plasmas

    Science.gov (United States)

    Bloomberg, H. W.; Berk, H. L.

    1973-01-01

    Equations are derived for describing the inhomogeneous equilibrium and small deviations from the equilibrium, giving particular attention to systems with trapped particles. An investigation is conducted of periodic systems with a single trapped-particle water bag, taking into account the behavior of the perturbation equations at the turning points. An outline is provided concerning a procedure for obtaining the eigenvalues. The results of stability calculations connected with the sideband effects are considered along with questions regarding the general applicability of the multiple water-bag approach in stability calculations.

  14. M1-transitions in the MIT bag model

    International Nuclear Information System (INIS)

    Hackman, R.H.; Deshpande, N.G.; Dicus, D.A.; Teplitz, V.L.

    1977-03-01

    In the MIT bag model, the M1-transitions of low lying hadrons are investigated. The following calculations are performed: 32 hadron masses are recomputed with a choice of bag parameters designed to give the correct values for the proton magnetic moment, μ/sub p/, and several masses, M/sub rho/ M/sub ω/ M/sub Δ/ M/sub Ω/, and M/sub D/; (2) eta, eta', eta/sub c/ mixing is computed in an untrustworthy approximation; and the widths for 38 M1-transitions are computed

  15. Pion-nucleon scattering in the Chiral bag model

    International Nuclear Information System (INIS)

    Israilov, Z.Z.; Musakhanov, M.M.

    1981-01-01

    The effective hamiltonian of the πNΔ-system in the framework of the Chiral Bag Model (CBM) contains πNN-, πNΔ-, πΔΔ-interaction terms with a form factor which is esstentially dependent on the size and shape of the quark bag. The interation of the Born graphs of this model provides successful description of the (3,3) and (3,1) phase shifts [in the (3,3) resonance region] where the values of the paramters agree with the CBM. (orig.)

  16. Analysis of flexible fabric structures for large-scale subsea compressed air energy storage

    International Nuclear Information System (INIS)

    Pimm, A; Garvey, S

    2009-01-01

    The idea of storing compressed air in submerged flexible fabric structures anchored to the seabed is being investigated for its potential to be a clean, economically-attractive means of energy storage which could integrate well with offshore renewable energy conversion. In this paper a simple axisymmetric model of an inextensional pressurised bag is presented, along with its implementation in a constrained multidimensional optimization used to minimise the cost of the bag materials per unit of stored energy. Base pressure difference and circumferential stress are included in the optimization, and the effect of hanging ballast masses from the inside of the bag is also considered. Results are given for a zero pressure natural shape bag, a zero pressure bag with circumferential stress and hanging masses, and a nonzero pressure bag with circumferential stress and hanging masses.

  17. Regulation

    International Nuclear Information System (INIS)

    Ballereau, P.

    1999-01-01

    The different regulations relative to nuclear energy since the first of January 1999 are given here. Two points deserve to be noticed: the decree of the third august 1999 authorizing the national Agency for the radioactive waste management to install and exploit on the commune of Bures (Meuse) an underground laboratory destined to study the deep geological formations where could be stored the radioactive waste. The second point is about the uranium residues and the waste notion. The judgment of the administrative tribunal of Limoges ( 9. july 1998) forbidding the exploitation of a storage installation of depleted uranium considered as final waste and qualifying it as an industrial waste storage facility has been annulled bu the Court of Appeal. It stipulated that, according to the law number 75663 of the 15. july 1965, no criteria below can be applied to depleted uranium: production residue (possibility of an ulterior enrichment), abandonment of a personal property or simple intention to do it ( future use aimed in the authorization request made in the Prefecture). This judgment has devoted the primacy of the waste notion on this one of final waste. (N.C.)

  18. BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR-29b and enhancing MMP2 expression.

    Science.gov (United States)

    Habata, Shutaro; Iwasaki, Masahiro; Sugio, Asuka; Suzuki, Miwa; Tamate, Masato; Satohisa, Seiro; Tanaka, Ryoichi; Saito, Tsuyoshi

    2015-05-01

    Approximately 30% of uterine corpus carcinomas are diagnosed at an advanced stage and have a poor prognosis. Our previous study indicated that BCL2-associated athanogene 3 (BAG3) enhances matrix metalloproteinase-2 (MMP2) expression and binds to MMP2 to positively regulate the process of cell invasion in ovarian cancer cells. Recently, altered miRNA expression patterns were observed in several groups of patients with endometrial cancers. One of the altered miRNAs, miR-29b, reportedly reduces tumor invasiveness by suppressing MMP2 expression. Our aim in the present study was to examine the relationships among BAG3, miR-29b and MMP2 in endometrioid adenocarcinoma cells. We found that BAG3 suppresses miR-29b expression and enhances MMP2 expression, which in turn increases cell motility and invasiveness. Moreover, restoration of miR-29b through BAG3 knockdown reduced MMP2 expression, as well as cell motility and invasiveness. Collectively, our findings indicate that BAG3 enhances MMP2 expression by suppressing miR-29b, thereby increasing the metastatic potential of endometrioid adenocarcinomas.

  19. T-piece resuscitator versus self-inflating bag for preterm resuscitation: an institutional experience.

    Science.gov (United States)

    Jayaram, Archana; Sima, Adam; Barker, Gail; Thacker, Leroy R

    2013-07-01

    Manual ventilation in the delivery room is provided with devices such as self-inflating bags (SIBs), flow-inflating bags, and T-piece resuscitators. To compare the effect of type of manual ventilation device on overall response to resuscitation among preterm neonates born at Apgar score. Secondary outcomes were incidence of air leaks, need for chest compressions/epinephrine, need for intubation, and surfactant use. We identified 294 resuscitations requiring ventilation. SIB was used for 135 neonates, and T-piece was used for 159 neonates. There was no significant difference between the 1-min and 5-min Apgar scores between SIB and T-piece (P = .77 and P = .11, respectively), nor were there significant differences in secondary outcomes. The rate of rise of Apgar score was higher, by 0.47, with T-piece, compared to SIB (95% CI 0.08-0.87, P = .02). Although some manikin studies favor T-piece for providing reliable and consistent pressures, our experience did not indicate significant differences in effectiveness of resuscitation between the T-piece and SIB in preterm resuscitations.

  20. Comparison of face masks in the bag-mask ventilation of a manikin.

    Science.gov (United States)

    Redfern, D; Rassam, S; Stacey, M R; Mecklenburgh, J S

    2006-02-01

    We conducted a study investigating the effectiveness of four face mask designs in the bag-mask ventilation of a special manikin adapted to simulate a difficult airway. Forty-eight anaesthetists volunteered to bag-mask ventilate the manikin for 3 min with four different face masks. The primary outcome of the study was to calculate mean percentage leak from the face masks over 3 min. Anaesthetists were also asked to rate the face masks using a visual analogue score. The single-use scented intersurgical face mask had the lowest mean leak (20%). This was significantly lower than the mean leak from the single-use, cushioned 7,000 series Air Safety Ltd. face mask (24%) and the reusable silicone Laerdal face mask (27%) but not significantly lower than the mean leak from the reusable anatomical intersurgical face mask (23%). There was a large variation in both performance and satisfaction between anaesthetists with each design. This highlights the importance of having a variety of face masks available for emergency use.

  1. Closed loop engine control for regulating NOx emissions, using a two-dimensional fuel-air curve

    Science.gov (United States)

    Bourn, Gary D.; Smith, Jack A.; Gingrich, Jess W.

    2007-01-30

    An engine control strategy that ensures that NOx emissions from the engine will be maintained at an acceptable level. The control strategy is based on a two-dimensional fuel-air curve, in which air manifold pressure (AMP) is a function of fuel header pressure and engine speed. The control strategy provides for closed loop NOx adjustment to a base AMP value derived from the fuel-air curve.

  2. Dynamics of cesium-134 and biomass in treated and untreated turkey oak leaf-litter bags

    International Nuclear Information System (INIS)

    Croom, J.M.; Ragsdale, H.L.

    1978-01-01

    Litter bags were prepared from leaves harvested in late fall from turkey oak trees (Quercus laevis) tagged with 134 Cs. Untreated bags and bags treated by soaking in 1000 ppM HgCl 2 were placed in the field on Dec. 7, 1974. Five bags of each treatment were retrieved at 7-, 14-, and 30-day intervals as the experiment progressed. Treated bags remained free of visible fungal hyphae growth for 12 weeks. Untreated bags had lost more weight but less 134 Cs than treated bags after 14 and 56 days, respectively. After 9 months, untreated bags had lost 33% weight and 90% 134 Cs. Although 134 Cs is rapidly leached from litter (ecological half-life approximately equal to 12 weeks), some is retained by fungal hyphae on leaf-litter surfaces. This mechanism of mineral retention in the litter layer could represent adaptation at the ecosystem level for nutrient conservation

  3. Nonlinear cloudy bag model in the meson mean-field approximation

    International Nuclear Information System (INIS)

    Bunatyan, G.G.

    1989-01-01

    We investigate the cloudy bag model for the nucleon, including the essentially nonlinear interaction of the quarks with the meson field. From the boundary conditions, which guarantee the stability of the bag, we obtain equations for the size R of the bag, for the momentum p of the quarks, and for the mean pion field var-phi. We obtain an expression for the total energy E of the bag nucleon. By taking the appropriate averages of all the relations the calculations reduce to the case of a spherically symmetric bag. We show that in the general nonlinear cloudy bag model in question the equations for R, p, and var-phi have a simultaneous solution which corresponds to the absolute minimum of the bag energy E and, consequently, that there exists a stable equilibrium state of the bag nucleon

  4. Silencing of dedicator of cytokinesis (DOCK180) obliterates pregnancy by interfering with decidualization due to blockage of nuclear entry of autoimmune regulator (AIRE).

    Science.gov (United States)

    Mohan, Jasna Jagan; Narayan, Prashanth; Padmanabhan, Renjini Ambika; Joseph, Selin; Kumar, Pradeep G; Laloraya, Malini

    2018-03-08

    Dedicator of cytokinesis (DOCK 180) involved in cytoskeletal reorganization is primarily a cytosolic molecule. It is recently shown to be nuclear in HeLa cells but its nuclear function is not known. The spatiotemporal distribution of DOCK180 in uterus was studied in uterine cytoplasmic and nuclear compartments during the "window of implantation." The functional significance of nuclear DOCK180 was explored by homology modeling, co-immunoprecipitation assays, and mass spectrometric analysis. Dock180's role in early pregnancy was ascertained by Dock 180 silencing and subsequent quantitative real-time PCR and Western blotting analysis. Our study shows a nuclear DOCK180 in the uterus during "window of implantation." Estrogen and progesterone mediate expression and nuclear translocation of DOCK180. The nuclear function of DOCK180 is attributed to its ability to import autoimmune regulator (AIRE) into the nucleus. Silencing of Dock180 inhibited AIRE nuclear shuttling which influenced its downstream targets, thereby affecting decidualization with AIRE and HOXA-10 as the major players as well as lack of implantation site formation due to impact on angiogenesis-associated genes. DOCK180 has an indispensable role in pregnancy establishment as knocking down Dock180 abrogates pregnancy by a consolidated impact on decidualization and angiogenesis by regulating AIRE nuclear entry. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Kiondo Bag Boutique: A Serial Case for Introductory Financial Accounting

    Science.gov (United States)

    Siriwardane, Harshini P.

    2014-01-01

    Kiondo Bag Boutique is a hypothetical serial case involving a start-up retail business. The case evolves from an ambitious business idea to a successful business. Through the evolving business, the importance of accounting information is highlighted. Different iterations are used to illustrate the role of accounting in serving and managing…

  6. Bagged K-means clustering of metabolome data

    NARCIS (Netherlands)

    Hageman, J. A.; van den Berg, R. A.; Westerhuis, J. A.; Hoefsloot, H. C. J.; Smilde, A. K.

    2006-01-01

    Clustering of metabolomics data can be hampered by noise originating from biological variation, physical sampling error and analytical error. Using data analysis methods which are not specially suited for dealing with noisy data will yield sub optimal solutions. Bootstrap aggregating (bagging) is a

  7. Editorial: The need for reducing plastic shopping bag use and ...

    African Journals Online (AJOL)

    Editorial: The need for reducing plastic shopping bag use and disposal in Africa. S Rayne. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  8. Plastic-bag radon gas monitor and survey results

    International Nuclear Information System (INIS)

    Torri, G.

    1990-01-01

    The Plastic-bag radon monitor used in the Italian National Survey is described. The choice of this radon gas sampler has been determined by the peculiarity of the italian environmental monitoring program, which is carried out by several different regional laboratories. Results obtained in the past using this radon monitoring device are also reported. (author). 8 refs, 7 figs

  9. Effect of ruminal plastic bags on wellbeing of goats | Otsyina ...

    African Journals Online (AJOL)

    Presence of plastic bags in the rumen of the goats was clinically characterized by anorexia, severe depression, discomfort (grunting sounds), dehydration, firmness and asymmetrical distention of the abdomen, reduced ruminal movements, diarrhoea with intermittent constipation, recumbency and death. Severity of the ...

  10. Micro-mesh fabric pollination bags for switchgrass

    Science.gov (United States)

    Pollination bags for making controlled crosses between switchgrass plants were made from a polyester micro-mesh fabric with a mesh size of 41 µm which is smaller than the mean reported 43 µm diameter of switchgrass pollen. When used in paired plant crosses between switchgrass plants, the mean amoun...

  11. Review of safety reports involving electronic flight bags

    Science.gov (United States)

    2009-04-27

    Electronic Flight Bags (EFBs) are a relatively new device used by pilots. Even so, 37 safety-related events involving EFBs were identified from the public online Aviation Safety Reporting System (ASRS) database as of June 2008. In addition, two accid...

  12. Purple Urine Bag Syndrome: A Case Report | Gandhi | Internet ...

    African Journals Online (AJOL)

    Purple urine bag syndrome (PUBS) is an uncommon phenomenon reported mostly in chronically constipated, institutionalized females on an indwelling catheter. It can often cause tremendous distress among health care providers. Though the condition is generally described as benign, it should draw immediate attention to ...

  13. Developing Baby Bag Design by Using Kansei Engineering Method

    Science.gov (United States)

    Janari, D.; Rakhmawati, A.

    2016-01-01

    Consumer's preferences and market demand are essential factors for product's success. Thus, in achieving its success, a product should have design that could fulfill consumer's expectation. Purpose of this research is accomplishing baby bag product as stipulated by Kansei. The results that represent Kanseiwords are; neat, unique, comfortable, safe, modern, gentle, elegant, antique, attractive, simple, spacious, creative, colorful, durable, stylish, smooth and strong. Identification value on significance of correlation for durable attribute is 0,000 baby's bag. While the value of coefficient regression is 0,812 baby's bag.The result of the baby's bag final design selectionbased on the questionnaire 3 is resulting the combination of all design. Space for clothes, diaper's space, shoulder grip, side grip, bottle's heater pocket and bottle's pocket are derived from design 1. Top grip, space for clothes, shoulder grip, and side grip are derived from design 2.Others design that were taken are, spaces for clothes from design 3, diaper's space and clothes’ space from design 4.

  14. Some spectroscopic problems in the bag theory of quark confinement

    International Nuclear Information System (INIS)

    Jaffe, R.L.

    1976-04-01

    In addition to conventional mesons and baryons, the bag model predicts the existence of several classes of unusual hadrons. The spectroscopy of two classes of unconventional hadrons is discussed: first are the Q 2 antiQ 2 mesons; second are Q 3 baryons or QantiQ mesons with quantum numbers forbidden by the nonrelativistic quark model

  15. The neutron electric dipole moment in the cloudy bag model

    International Nuclear Information System (INIS)

    Morgan, M.A.; Miller, G.A.

    1986-01-01

    An evaluation of the neutron electric dipole moment (NEDM), using the cloudy bag model (CBM) shows that two CP-violating effects (a quark mass term and a pion-quark interaction) have contributions that are about equal in magnitude, but opposite in sign. This cancellation allows the upper limit on the θ parameter to increase by about an order of magnitude. (orig.)

  16. Clinical efficacy of a tea-bag formulation of Cryptolepis ...

    African Journals Online (AJOL)

    Objective: To evaluate the clinical efficacy and safety of a tea bag formulation of the root of C. sanguinolenta. Design: This is a prospective descriptive open trial. Setting: Patients were recruited from Korle-Bu, Mamprobi and Dansoman Polyclinics. Subjects: Forty-four subjects with uncomplicated malaria were recruited for ...

  17. The Effectiveness of a Collector Bag for Measurement of Post ...

    African Journals Online (AJOL)

    The aim of the study was to assess sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of collector bag and its correlation with hemoglobin (Hb) and hematocrit (Ht) variations. This study, carried on 100 women referred for admission to labor ward of Shohada hospital in Orumeyeh City, Iran, ...

  18. Emulsification in novel ultrasonic cavitation intensifying bag reactors

    NARCIS (Netherlands)

    Zwieten, van Ralph; Verhaagen, Bram; Schroën, Karin; Fernández Rivas, David

    2017-01-01

    Cavitation Intensifying Bags (CIBs), a novel reactor type for use with ultrasound, have been recently proposed as a scaled-up microreactor with increased energy efficiencies. We now report on the use of the CIBs for the preparation of emulsions out of hexadecane and an SDS aqueous solution. The

  19. 75 FR 36359 - Polyethylene Retail Carrier Bags From Thailand: Extension of Time Limit for Preliminary Results...

    Science.gov (United States)

    2010-06-25

    ...) Co., Ltd., Sahachit Watana Plastics Ind. Co., Ltd., Thai Plastic Bags Industries Co., Ltd., and Thantawan Industry Public Co., Ltd. Id. The Department has determined previously that Thai Plastic Bags Industries Co., Ltd., APEC Film Ltd., and Winner's Pack Co., Ltd., comprise the Thai Plastic Bags Group. See...

  20. 75 FR 23673 - Polyethylene Retail Carrier Bags from Thailand: Extension of Time Limit for Preliminary Results...

    Science.gov (United States)

    2010-05-04

    ... Co., Ltd., Landblue (Thailand) Co., Ltd., Sahachit Watana Plastics Ind. Co., Ltd., Thai Plastic Bags... that Thai Plastic Bags Industries Co., Ltd., APEC Film Ltd., and Winner's Pack Co., Ltd., comprise the Thai Plastic Bags Group (TPBG). See Notice of Final Determination of Sales at Less than Fair Value...

  1. 78 FR 88 - Polyethylene Retail Carrier Bags From the People's Republic of China: Rescission of Antidumping...

    Science.gov (United States)

    2013-01-02

    ... Bags From the People's Republic of China: Rescission of Antidumping Duty Administrative Review; 2011... duty order on polyethylene retail carrier bags (PRCBs) from the People's Republic of China (PRC) for... August 31, 2012, the petitioners, the Polyethylene Retail Carrier Bag Committee and its individual...

  2. 76 FR 11203 - Polyethylene Retail Carrier Bags From the People's Republic of China: Rescission of Antidumping...

    Science.gov (United States)

    2011-03-01

    ... Bags From the People's Republic of China: Rescission of Antidumping Duty Administrative Review AGENCY... administrative review of the antidumping duty order on polyethylene retail carrier bags (PRCBs) from the People's... the PRC. See Antidumping Duty Order: Polyethylene Retail Carrier Bags From the People's Republic of...

  3. 21 CFR 178.3730 - Piperonyl butoxide and pyrethrins as components of bags.

    Science.gov (United States)

    2010-04-01

    ... bags. 178.3730 Section 178.3730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... pyrethrins as components of bags. Piperonyl butoxide in combination with pyrethrins may be safely used for insect control on bags that are intended for use in contact with dried feed in compliance with §§ 561.310...

  4. 77 FR 2959 - Polyethylene Retail Carrier Bags From the People's Republic of China: Rescission of Antidumping...

    Science.gov (United States)

    2012-01-20

    ... Bags From the People's Republic of China: Rescission of Antidumping Duty Administrative Review AGENCY... administrative review of the antidumping duty order on polyethylene retail carrier bags (PRCBs) from the People's... Retail Carrier Bags From the People's Republic of China, 69 FR 48201 (August 9, 2004). On August 1, 2011...

  5. 76 FR 68137 - Polyethylene Retail Carrier Bags From Thailand: Amended Final Results of Antidumping Duty...

    Science.gov (United States)

    2011-11-03

    ... Bags From Thailand: Amended Final Results of Antidumping Duty Administrative Review AGENCY: Import..., the Department of Commerce (the Department) published Polyethylene Retail Carrier Bags From Thailand... 351.224(c) from the Polyethylene Retail Carrier Bag Committee and its individual members, Hilex Poly...

  6. 78 FR 76280 - Polyethylene Retail Carrier Bags From the People's Republic of China: Affirmative Preliminary...

    Science.gov (United States)

    2013-12-17

    ... Bags From the People's Republic of China: Affirmative Preliminary Determination of Circumvention of the... determines that imports of unfinished polyethylene retail carrier bags (PRCBs) from the People's Republic of... Duty Order: Polyethylene Retail Carrier Bags From the People's Republic of China, 69 FR 48201 (August 9...

  7. Effect of pre-harvest fruit bagging on post-harvest quality of guava cv. Swarupkathi

    Directory of Open Access Journals (Sweden)

    Md. Mokter Hossain

    2018-04-01

    The investigation was carried out at Germplasm Centre (BAU-GPC, Bangladesh Agricultural University, during March to July 2016 in order to investigate the effect of pre-harvest fruit bagging on post-harvest quality of guava cv. Swarupkathi. Four different bagging materials viz. brown paper bag, white paper bag, white polythene bag, black polythene bag included for the study and uncovered fruits were used as control treatment. The experiment was laid out in randomized complete block design with three replications. Fruit bagging treatments showed significant effects on different parameters studied. It was observed that fruit size, fruit weight, vitamin C concentration, and moisture content increased due to fruit bagging. Fruits were gained maximum in size (6.59 cm length, 5.86 cm diameter and weight (164.26 g under white paper bag followed by white polythene bag (131.3g. The skin color of fruits was very attractive in case of white paper bag than that of other treatments. Total soluble solid concentration of the fruit was found maximum (12.33% Brix under brown paper bag while maximum vitamin C concentration (162.14 mg 100 g-1 was recorded under white paper bag. Uncovered fruits showed maximum total sugar, non-reducing sugar, reducing sugar concentrations (10.13%, 6.05%, 4.08%, respectively.The results revealed that fruit bagging in general, improved the growth and quality of guava fruits as compared to control. Among the various fruit covering materials, white paper bag was found to be the best for overall improvement of physical and chemical quality of guava cv. Swarupkathi. [Fundam Appl Agric 2018; 3(1.000: 363-371

  8. Can "contamination" occur in body bags?-The example of background fibres in body bags used in Australia.

    Science.gov (United States)

    Schwendener, Giuliana; Moret, Sébastien; Cavanagh-Steer, Karen; Roux, Claude

    2016-09-01

    Impurities that are transferred to a crime scene or a body can have a significant negative impact on the investigation if the existence of the contamination is not known, and the source of the contamination is not identified. Forensic consumables, such as DNA swabs, have been known to have caused contaminations, wrongfully linking crimes throughout Europe. In that context, this study focused on body bags, widely used to transfer a corpse from the crime scene to the morgue. Our preliminary survey showed that several countries and Australian Jurisdictions are conducting the sampling of trace evidence at the morgue after the transportation of the body. Potential impurities present in body bags could thus interfere with pertinent traces. The aim of this work was to qualify and quantify the background contamination of trace evidence in body bags used within Australia. Fifteen body bags from four Australian Jurisdictions or laboratories were searched for micro traces. Impurities such as fibres and unidentified particles were detected in each examined body bag, with an estimated average of 3603 coloured fibres and 1429 unidentified particles. This number of fibres is similar to the amount found on a vinyl cinema seat in other studies. Various other contaminants such as pieces of fabric, hairs, parts of insects or feathers were also observed. It is hypothesised that these impurities are introduced during the manufacturing process. This high number of impurities can lead to incorrect conclusions and misleading investigative leads. This paper presents an overview of the problems these impurities can cause and proposes several strategies to prevent future issues. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Non-leptonic hyperon decays and the chiral meson coupling to bags

    International Nuclear Information System (INIS)

    Horvat, D.; Tadic, D.

    1986-01-01

    Hyperon nonleptonic decays have been analyzed using a chiral-bag model instead of the MIT-bag model which was used in earlier analyses. The adopted theoretical formalism allows a step by step comparison between the new and the old approaches. The results are in agreement with the calculation which has used chiral model in its cloudy-bag variant. Chiral-bag model based theoretical predictions are not significantly different from the old MIT-bag model based results. Theory can account for overall gross features of the hyperon nonleptonic decays but not for the fine details like the exact, almost vanishing, value of the A(Σsub(+) + ) amplitude. (orig.)

  10. Towards an agent based traffic regulation and recommendation system for the on-road air quality control

    OpenAIRE

    Sadiq, Abderrahmane; El Fazziki, Abdelaziz; Ouarzazi, Jamal; Sadgal, Mohamed

    2016-01-01

    This paper presents an integrated and adaptive problem-solving approach to control the on-road air quality by modeling the road infrastructure, managing traffic based on pollution level and generating recommendations for road users. The aim is to reduce vehicle emissions in the most polluted road segments and optimizing the pollution levels. For this we propose the use of historical and real time pollution records and contextual data to calculate the air quality index on road networks and gen...

  11. A simple air sampling technique for monitoring nitrous oxide pollution

    Energy Technology Data Exchange (ETDEWEB)

    Austin, J C; Shaw, R; Moyes, D; Cleaton-Jones, P E

    1981-01-01

    A simple, inexpensive device for the continuous low-flow sampling of air was devised to permit monitoring of pollution by gaseous anaesthetics. The device consisted of a water-filled Perspex cylinder in which a double-walled flexible-film gas sample collection bag was suspended. Air samples could be aspirated into the collection bag at flow rates of as low as 1 ml min-1 by allowing the water to drain from the cylinder at a controlled rate. The maintenance of sample integrity with aspiration and storage of samples of nitrous oxide in air at concentrations of 1000, 100 and 30 p.p.m. v/v was examined using gas chromatography. The sample bags retained a mean 94% of the nitrous oxide in air samples containing nitrous oxide 25 p.p.m. over a 72-h storage period.

  12. Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma.

    Science.gov (United States)

    Loza-Correa, M; Kalab, M; Yi, Q-L; Eltringham-Smith, L J; Sheffield, W P; Ramirez-Arcos, S

    2017-07-01

    Canadian Blood Services produces apheresis and buffy coat pooled platelet concentrates (PCs) stored in bags produced by two different manufacturers (A and B, respectively), both made of polyvinyl chloride-butyryl trihexyl citrate. This study was aimed at comparing Staphylococcus epidermidis adhesion to the inner surface of both bag types in the presence or absence of plasma factors. Sets (N = 2-6) of bags type A and B were left non-coated (control) or preconditioned with platelet-rich, platelet-poor or defibrinated plasma (PRP, PPP and DefibPPP, respectively). Each bag was inoculated with a 200-ml S. epidermidis culture adjusted to 0·5 colony-forming units/ml. Bags were incubated under platelet storage conditions for 7 days. After culture removal, bacteria attached to the plastic surface were either dislodged by sonication for bacterial quantification or examined in situ by scanning electron microscopy (SEM). Higher bacterial adhesion was observed to preconditioned PC bags than control containers for both bag types (P bags was confirmed by SEM. Bacteria adhered equally to both types of containers in the presence of PRP, PPP and DefibPPP residues (P > 0·05). By contrast, a significant increase in bacterial adherence was observed to type A bags compared with type B bags in the absence of plasma (P bags depends on the presence of plasma factors. Future efforts should be focused on reducing plasma proteins' attachment to platelet storage containers to decrease subsequent bacterial adhesion. © 2017 International Society of Blood Transfusion.

  13. The Portuguese plastic carrier bag tax: The effects on consumers' behavior.

    Science.gov (United States)

    Martinho, Graça; Balaia, Natacha; Pires, Ana

    2017-03-01

    Marine litter from lightweight plastic bags is a global problem that must be solved. A plastic bag tax was implemented in February 2015 to reduce the consumption of plastic grocery bags in Portugal and in turn reduce the potential contribution to marine litter. This study analyzes the effect of the plastic bag tax on consumer behavior to learn how it was received and determine the perceived effectiveness of the tax 4months after its implementation. In addition, the study assessed how proximity to coastal areas could influence behaviors and opinions. The results showed a 74% reduction of plastic bag consumption with a simultaneously 61% increase of reusable plastic bags after the tax was implemented. Because plastic bags were then reused for shopping instead of garbage bags, however, the consumption of garbage bags increased by 12%. Although reduction was achieved, the tax had no effect on the perception of marine litter or the impact of plastic bags on environment and health. The majority of respondents agree with the tax but view it as an extra revenue to the State. The distance to the coast had no meaningful influence on consumer behavior or on the perception of the tax. Although the tax was able to promote the reduction of plastics, the role of hypermarkets and supermarkets in providing alternatives through the distribution of reusable plastic bags was determinant to ensuring the reduction. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. FUNGAL POPULATION, AFLATOXIN AND FREE FATTY ACID CONTENTS OF PEANUTS PACKED IN DIFFERENT BAG TYPES

    Directory of Open Access Journals (Sweden)

    SONIA S.P. BULAONG

    2002-01-01

    Full Text Available Shelled peanuts of Gajah var. with initial moisture content of 7% were stored at 11 kg/bag in four bag types namely: jute bag, polypropylene bag, jute bag doubled with thin polyethylene (PE, and jute bag doubled with thick PE. Storage was done for six months under warehouse conditions with monitoring of relative humidity and temperature. Samples taken at the be ginning of storage and every month thereafter were analyzed for moisture content, fungal population, aflatoxin and free fatty acid contents. Statistical analyses showed that moisture content, fungal population, and free fatty acid contents were signifi cantly higher in jute and polypropylene bags than in PE-dou,bled jute bags. No significant differences were obtained in aflatoxin contents among bag types but at the end of six months storage, toxin level in jute bag exceeded the 30 ppb limit. Polypropylene had second highest toxin level at 23 ppb. The PE-doubled bags ha d 17 and 19 ppb total aflatoxins for thin and thick films, respectively. The results indicated that the immediate packag ing of dried shelled peanuts at safe moisture level in plastic films with water vapor transmission rated of 1 g/m2/24 hr or lower is recommended. This p ackaging will delay critical increases in moisture content, fungal population, aflatoxin and free fatty acid contents of peanut kernels at ambient storage conditions.

  15. Ammonia Diffusion through Nalophan Double Bags: Effect of Concentration Gradient Reduction

    Science.gov (United States)

    Capelli, Laura; Boiardi, Emanuela; Del Rosso, Renato

    2014-01-01

    The ammonia loss through Nalophan bags has been studied. The losses observed for storage conditions and times as allowed by the reference standard for dynamic olfactometry (EN 13725:2003) indicate that odour concentration values due to the presence of small molecules may be significantly underestimated if samples are not analysed immediately after sampling. A diffusion model was used in order to study diffusion through the bag. The study discusses the effect of concentration gradient (ΔC) across the polymeric membrane of the analyte. The ΔC was controlled by using a setup bag called “double bags.” Experimental data show a reduction of ammonia percentage losses due to the effect of the external multibarrier. The expedient of the double bag loaded with the same gas mixture allows a reduced diffusion of ammonia into the inner bag. Comparing the inner bag losses with those of the single bag stored in the same conditions (T, P, u) and with equal geometrical characteristics (S/V, z), it was observed that the inner bag of the double bag displays a 16% loss while the single bag displays a 37% loss. Acting on the ΔC it is possible to achieve a gross reduction of 57% in the ammonia leakage due to diffusion. PMID:25506608

  16. Ammonia diffusion through Nalophan double bags: effect of concentration gradient reduction.

    Science.gov (United States)

    Sironi, Selena; Eusebio, Lidia; Capelli, Laura; Boiardi, Emanuela; Del Rosso, Renato

    2014-01-01

    The ammonia loss through Nalophan bags has been studied. The losses observed for storage conditions and times as allowed by the reference standard for dynamic olfactometry (EN 13725:2003) indicate that odour concentration values due to the presence of small molecules may be significantly underestimated if samples are not analysed immediately after sampling. A diffusion model was used in order to study diffusion through the bag. The study discusses the effect of concentration gradient (ΔC) across the polymeric membrane of the analyte. The ΔC was controlled by using a setup bag called "double bags." Experimental data show a reduction of ammonia percentage losses due to the effect of the external multibarrier. The expedient of the double bag loaded with the same gas mixture allows a reduced diffusion of ammonia into the inner bag. Comparing the inner bag losses with those of the single bag stored in the same conditions (T, P, u) and with equal geometrical characteristics (S/V, z), it was observed that the inner bag of the double bag displays a 16% loss while the single bag displays a 37% loss. Acting on the ΔC it is possible to achieve a gross reduction of 57% in the ammonia leakage due to diffusion.

  17. BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

    Science.gov (United States)

    Minoia, Melania; Boncoraglio, Alessandra; Vinet, Jonathan; Morelli, Federica F; Brunsting, Jeanette F; Poletti, Angelo; Krom, Sabine; Reits, Eric; Kampinga, Harm H; Carra, Serena

    2014-01-01

    Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradation pathways. Upon proteasomal impairment, cells switch to autophagy to ensure proper clearance of clients (the proteasome-to-autophagy switch). The HSPA8 and HSPA1A cochaperone BAG3 has been suggested to be involved in this switch. However, at present it is still unknown whether and to what extent BAG3 can indeed reroute proteasomal clients to the autophagosomal pathway. Here, we show that BAG3 induces the sequestration of ubiquitinated clients into cytoplasmic puncta colabeled with canonical autophagy linkers and markers. Following proteasome inhibition, BAG3 upregulation significantly contributes to the compensatory activation of autophagy and to the degradation of the (poly)ubiquitinated proteins. BAG3 binding to the ubiquitinated clients occurs through the BAG domain, in competition with BAG1, another BAG family member, that normally directs ubiquitinated clients to the proteasome. Therefore, we propose that following proteasome impairment, increasing the BAG3/BAG1 ratio ensures the “BAG-instructed proteasomal to autophagosomal switch and sorting” (BIPASS). PMID:25046115

  18. Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia.

    Science.gov (United States)

    Zhu, Huayuan; Wu, Wei; Fu, Yuan; Shen, Wenyi; Miao, Kourong; Hong, Min; Xu, Wei; Young, Ken H; Liu, Peng; Li, Jianyong

    2014-03-01

    Bcl-2-associated athanogene 3 (BAG3), a member of BAG family, is shown to sustain cell survival and underlie resistance to chemotherapy in human neoplastic cells. We aimed to determine the exact role and underlying mechanisms of BAG3 in human chronic lymphocytic leukemia (CLL). One hundred human CLL samples and 20 normal B-cell samples from healthy controls were collected. We measured the BAG3 expression in these cells and explored its relationship with known prognostic factors for CLL. The roles of BAG3 in cell apoptosis and migration were evaluated by small interfering RNA-mediated knockdown of BAG3 in primary CLL cells. We showed that BAG3 expression level was increased in CLL cells compared with normal B cells. Moreover, BAG3 expression was particularly upregulated in CD38 positive, unmutated immunoglobulin heavy-chain patients and those with lymphadenopathy and/or splenomegaly. Importantly, patients with increased BAG3 expression level have poor overall survival in subgroups with positive ZAP-70 or those without any "p53 abnormality". In addition, knocking down of BAG3 expression resulted in increased apoptotic ratio and decreased migration in primary CLL cells. Our data indicate that BAG3 is a marker of poor prognostic in specific subgroups of CLL patients and may be a potential therapeutic target for this disease.

  19. Final Rule for Control of Air Pollution From Motor Vehicles and New Motor Vehicle Engines; Modification of Federal Onboard Diagnostic Regulations for Light-Duty Vehicles and Light-Duty Trucks; Extension of Acceptance of California OBD

    Science.gov (United States)

    This action finalizes modifications to the federal on-board diagnostics regulations, including: harmonizing the emission levels above which a component or system is considered malfunctioning with those of the California Air Resources Board (CARB).

  20. Comparison of cryopreservation bags for hematopoietic progenitor cells using a WBC-enriched product.

    Science.gov (United States)

    Dijkstra-Tiekstra, Margriet J; Hazelaar, Sandra; Gkoumassi, Effimia; Weggemans, Margienus; de Wildt-Eggen, Janny

    2015-04-01

    Hematopoietic progenitor cells (HPC) are stored in cryopreservation bags that are resistant to liquid nitrogen. Since Cryocyte bags of Baxter (B-bags) are no longer available, an alternative bag was sought. Also, the influence of freezing volume was studied. Miltenyi Biotec (MB)- and MacoPharma (MP)-bags passed the integrity tests without failure. Comparing MB- and MP-bags with B-bags, no difference in WBC recovery or viability was found when using a WBC-enriched product as a "dummy" HPC product. Further, a freezing volume of 30 mL resulted in better WBC recovery and viability than 60 mL. Additonal studies using real HPC might be necessary. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Design of Control System for Flexible Packaging Bags Palletizing Production Line Based on PLC

    Science.gov (United States)

    Zheng, Huiping; Chen, Lin; Zhao, Xiaoming; Liu, Zhanyang

    Flexible packaging bags palletizing production line is to put the bags in the required area according to particular order and size, in order to finish handling, storage, loading and unloading, transportation and other logistics work of goods. Flexible packaging bags palletizing line is composed of turning bags mechanism, shaping mechanism, indexing mechanism, marshalling mechanism, pushing bags mechanism, pressing bags mechanism, laminating mechanism, elevator, tray warehouse, tray conveyor and loaded tray conveyor. Whether the whole production line can smoothly run depends on each of the above equipment and precision control among them. In this paper the technological process and the control logic of flexible packaging bags palletizing production line is introduced. Palletizing process of the production line realized automation by means of a control system based on programmable logic controller (PLC). It has the advantages of simple structure, reliable and easy maintenance etc.

  2. Catalytic pleat filter bags for combined particulate separation and nitrogen oxides removal from flue gas streams

    International Nuclear Information System (INIS)

    Park, Young Ok; Choi, Ho Kyung

    2010-01-01

    The development of a high temperature catalytically active pleated filter bag with hybrid filter equipment for the combined removal of particles and nitrogen oxides from flue gas streams is presented. A special catalyst load in stainless steel mesh cartridge with a high temperature pleated filter bag followed by optimized catalytic activation was developed to reach the required nitrogen oxides levels and to maintain the higher collection efficiencies. The catalytic properties of the developed high temperature filter bags with hybrid filter equipment were studied and demonstrated in a pilot scale test rig and a demonstration plant using commercial scale of high temperature catalytic pleated filter bags. The performance of the catalytic pleated filter bags were tested under different operating conditions, such as filtration velocity and operating temperature. Moreover, the cleaning efficiency and residual pressure drop of the catalyst loaded cartridges in pleated filter bags were tested. As result of theses studies, the optimum operating conditions for the catalytic pleated filter bags are determined. (author)

  3. Expression of Anti-apoptotic Protein BAG3 in Human Sebaceous Gland Carcinoma of the Eyelid.

    Science.gov (United States)

    Yunoki, Tatsuya; Tabuchi, Yoshiaki; Hayashi, Atsushi

    2017-04-01

    Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play a role in anti-apoptosis of various malignant tumors. In this study, the expression of BAG3 was examined in human sebaceous gland carcinoma of the eyelid. The expression of BAG3 was evaluated by immunohistochemistry of surgical samples from 5 patients with sebaceous gland carcinoma in the eyelid. BAG3 was positive diffusely in the cytoplasm in all patients. The average positive rate of BAG3 was 73.0±26.0% in tumor cells of all patients. BAG3 was highly expressed in sebaceous gland carcinoma of the eyelid. BAG3 may play an important role in the pathogenesis and progression of sebaceous gland carcinoma of the eyelid. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  4. Components for containment enclosures. Part 4: Ventilation and gas-cleaning systems such as filters, traps, safety and regulation valves, control and protection devices

    International Nuclear Information System (INIS)

    2001-01-01

    ISO 11933 consists of the following parts, under the general title Components for containment enclosures: Part 1: Glove/bag ports, bungs for glove/bag ports, enclosure rings and interchangeable units; Part 2: Gloves, welded bags, gaiters for remote-handling tongs and for manipulators; Part 3: Transfer systems such as plain doors, airlock chambers, double door transfer systems, leaktight connections for waste drums; Part 4: Ventilation and gas-cleaning systems such as filters, traps, safety and regulation valves, control and protection devices; Part 5: Penetrations for electrical and fluid circuits. This part of ISO 11933 specifies the design criteria and the characteristics of various components used for ventilation and gas-cleaning in containment enclosures. These components are either directly fixed to the containment enclosure wall, or used in the environment of a shielded or unshielded containment enclosure or line of such enclosures. They can be used alone or in conjunction with other mechanical components, including those specified in ISO 11933-1 and ISO 11933-3. This part of ISO 11933 is applicable to: filtering devices, including high-efficiency particulate air (HEPA) filters and iodine traps; safety valves and pressure regulators; systems ensuring the mechanical protection of containment enclosures; control and pressure-measurement devices

  5. Experiences in certification of packages for transportation of fresh nuclear fuel in the context of new safety requirements established by IAEA regulations (IAEA-96 regulations, ST-1) for air transportation of nuclear materials (requirements to C-type packages)

    Energy Technology Data Exchange (ETDEWEB)

    Dudai, V.I.; Kovtun, A.D.; Matveev, V.Z.; Morenko, A.I.; Nilulin, V.M.; Shapovalov, V.I.; Yakushev, V.A.; Bobrovsky, V.S.; Rozhkov, V.V.; Agapov, A.M.; Kolesnikov, A.S. [Russian Federal Nuclear Centre - All-Russian Research Inst. of Experimental Physics, Sarov (Russian Federation)]|[JSC ' ' MSZ' ' , Electrostal (Russian Federation)]|[JSC ' ' NPCC' ' , Novosibirsk (Russian Federation)]|[Minatom of Russia, Moscow (Russian Federation)]|[Gosatomnadzor of Russia, Moscow (Russian Federation)

    2004-07-01

    Every year in Russia, a large amount of domestic and international transportation of fresh nuclear fuel (FNF) used in Russian and foreign energy and research atomic reactors and referred to fissile materials based on IAEA Regulations is performed. Here, bulk transportation is performed by air, and it concerns international transportation in particular. According to national ''Main Regulations for Safe Transport and physical Protection of Nuclear Materials (OPBZ- 83)'' and ''Regulations for the Safe Transport of Radioactive Materials'' of the International Atomic Energy Agency (IAEA Regulations), nuclear and radiation security under normal (accident free) and accident conditions of transport must be completely provided by the package design. In this context, high requirements to fissile packages exposed to heat and mechanical loads in transport accidents are imposed. A long-standing experience in accident free transportation of FM has shown that such approach to provide nuclear and radiation security pays for itself completely. Nevertheless, once in 10 years the International Atomic Energy Agency on every revision of the ''Regulations for the Safe Transport of Radioactive Materials'' places more stringent requirements upon the FM and transportation thereof, resulting from the objectively increasing risk associated with constant rise in volume and density of transportation, and also strained social and economical situation in a number of regions in the world. In the new edition of the IAEA Regulations (ST-1), published in 1996 and brought into force in 2001 (IAEA-96 Regulations), the requirements to FM packages conveyed by aircraft were radically changed. These requirements are completely presented in new Russian ''Regulations for the Safe Transport of Radioactive Materials'' (PBTRM- 2004) which will be brought into force in the time ahead.

  6. Brucella Melitensis 16M Regulates the Effect of AIR Domain on Inflammatory Factors, Autophagy, and Apoptosis in Mouse Macrophage through the ROS Signaling Pathway.

    Directory of Open Access Journals (Sweden)

    Tiansen Li

    Full Text Available Brucellosis is a highly contagious zoonosis caused by Brucella. Brucella can invade and persist inside host cells, which results in chronic infection. We constructed AIR interference and overexpression lentiviruses to acquire AIR interference, overexpression, and rescue stable expression cell lines. We also established a Brucella melitensis 16M-infected macrophage model, which was treated with either the vehicle control or NAC (ROS scavenger N-acetylcysteine (NAC for 0, 3, 6, 12, and 24 h. Confocal laser microscopy, transmission electron microscopy, fluorescence quantitative PCR, flow cytometry, ELISA, and Western blot were used to detect inflammation, cell autophagy and apoptosis-related protein expression levels, ROS levels, and the distribution of mitochondria. It was found that after interference and overexpression of AIR, ROS release was significantly changed, and mitochondria became abnormally aggregated. B. melitensis 16M activated the NLRP3/AIM2 inflammatory complex, and induced RAW264.7 cells to secrete IL-1β and IL-18 through the ROS pathway. B. melitensis 16M also altered autophagy-related gene expression, increased autophagy activity, and induced cell apoptosis through the ROS pathway. The results showed that after B. melitensis 16M infection, ROS induced apoptosis, inflammation, and autophagy while AIR inhibited autophagosome maturation and autophagy initiation. Autophagy negatively regulated the activation of inflammasomes and prevented inflammation from occurring. In addition, mitophagy could promote cell apoptosis.

  7. Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults.

    Science.gov (United States)

    Calderón-Garcidueñas, Lilian; Kavanaugh, Michael; Block, Michelle; D'Angiulli, Amedeo; Delgado-Chávez, Ricardo; Torres-Jardón, Ricardo; González-Maciel, Angelica; Reynoso-Robles, Rafael; Osnaya, Norma; Villarreal-Calderon, Rodolfo; Guo, Ruixin; Hua, Zhaowei; Zhu, Hongtu; Perry, George; Diaz, Philippe

    2012-01-01

    Air pollution exposures have been linked to neuroinflammation and neuropathology. Autopsy samples of the frontal cortex from control (n = 8) and pollution-exposed (n = 35) children and young adults were analyzed by RT-PCR (n = 43) and microarray analysis (n = 12) for gene expression changes in oxidative stress, DNA damage signaling, NFκB signaling, inflammation, and neurodegeneration pathways. The effect of apolipoprotein E (APOE) genotype on the presence of protein aggregates associated with Alzheimer's disease (AD) pathology was also explored. Exposed urbanites displayed differential (>2-fold) regulation of 134 genes. Forty percent exhibited tau hyperphosphorylation with pre-tangle material and 51% had amyloid-β (Aβ) diffuse plaques compared with 0% in controls. APOE4 carriers had greater hyperphosphorylated tau and diffuse Aβ plaques versus E3 carriers (Q = 7.82, p = 0.005). Upregulated gene network clusters included IL1, NFκB, TNF, IFN, and TLRs. A 15-fold frontal down-regulation of the prion-related protein (PrP(C)) was seen in highly exposed subjects. The down-regulation of the PrP(C) is critical given its important roles for neuroprotection, neurodegeneration, and mood disorder states. Elevation of indices of neuroinflammation and oxidative stress, down-regulation of the PrP(C) and AD-associated pathology are present in young megacity residents. The inducible regulation of gene expression suggests they are evolving different mechanisms in an attempt to cope with the constant state of inflammation and oxidative stress related to their environmental exposures. Together, these data support a role for air pollution in CNS damage and its impact upon the developing brain and the potential etiology of AD and mood disorders.

  8. Testing of SRS and RFETS Nylon Bag Material

    International Nuclear Information System (INIS)

    Laurinat, J.E.

    1998-01-01

    This report compares the effects of radiation and heating on nylon bagout materials used at the Savannah River Site (SRS) and the Rocky Flats Environmental Technology Site (RFETS). Recently, to simplify the processing of sand, slag, and crucible (SS and C), FB-Line has replaced the low-density polyethylene (LDPE) and polyvinyl chloride (PVC) bags normally used to package cans of plutonium-bearing material with nylon bags. LDPE and PVC are not soluble in the nitric acid dissolver solution used in F-Canyon, so cans bagged using these materials had to be repackaged before they were added to the dissolver. Because nylon dissolves in nitric acid, cans bagged in nylon can be charged to the F-Canyon dissolvers without repackaging, thereby reducing handling requirements and personnel exposure. As part of a program to process RFETS SS and C at SRS, RFETS has also begun to use a nylon bagout material. The RFETS bag materials is made from a copolymer of nylon 6 and nylon 6.9, while the SRS material is made from a nylon 6 monomer. In addition, the SRS nylon has an anti-static agent added. The RFETS nylon is slightly softer than the SRS nylon, but does not appear to be as resistant to flex cracks initiated by contact with sharp corners of the inner can containing the SS and C.2 FB-Line Operations has asked for measurement of the effects of radiation and heating on these materials. Specifically, they have requested a comparison of the material properties of the plastics before and after irradiation, a measurement of the amount of outgassing when the plastics are heated, and a calculation of the amount of radiolytic gas generation. Testing was performed on samples taken from material that is currently used in FB-Line (color coded orange) and at RFETS. The requested tests are the same tests previously performed on the original and replacement nylon and LDPE bag materials.3,4,5. To evaluate the effect of irradiation on material properties, tensile stresses and elongations to break

  9. Purple Urine Bag Syndrome: A Rare Spot Diagnosis.

    Science.gov (United States)

    Kalsi, Dilraj S; Ward, Joel; Lee, Regent; Handa, Ashok

    2017-01-01

    Purple urine bag syndrome (PUBS) is a complication of urinary tract infections (UTIs) where catheter bags and tubing turn purple. It is alarming for patients, families, and clinicians; however, it is in itself a benign phenomenon. PUBS is the result of UTIs with specific bacteria that produce sulphatases and phosphatases which lead tryptophan metabolism to produce indigo (blue) and indirubin (red) pigments, a mixture of which becomes purple. Risk factors include female gender, immobility, constipation, chronic catheterisation, and renal disease. Management involves reassurance, antibiotics, and regular changing of catheters, although there are debates regarding how aggressively to treat and no official guidelines. Prognosis is good, but PUBS is associated with high morbidity and mortality due to the backgrounds of patients. Here, we review the literature available on PUBS, present a summary of case studies from the last five years, and propose the Oxford Urine Chart as a tool to aid such diagnoses.

  10. Quantum fluctuations in the bag and nucleon observables

    International Nuclear Information System (INIS)

    Maxwell, O.V.; Vento, V.

    1982-03-01

    A time-dependent, perturbative formalism is developed to describe the effect of quantum fluctuations of the quark fields inside a hadronic bag on physical observables. This formalism differs from previous ones in that (1) all contributions to second order in the QCD coupling constant are generated systematically and included in the numerical treatment; (2) the intermediate sums are carried out over a full set of states consistent with parity and SU(2) coupling rules. After removing the logarithmic divergences arising from the intermediate state sums in the 1-body terms and applying a finite renormalization, the second order fluctuation corrections to several proton and neutron observables are computed. The results obtained are significantly different from those obtained in earlier calculations. In no case considered are the calculated corrections sufficient to account for existing discrepancies between empirical values and lower order hadronic bag results for nucleon observables

  11. Pioneras del punk: el caso de Alice Bag

    Directory of Open Access Journals (Sweden)

    Soraya Alonso Alconada

    2017-10-01

    Full Text Available El objetivo de este trabajo es presentar a la música chicana Alice Bag como una de las figuras influyentes en la temprana escena punk de Los Ángeles, California, quien ayudó a abrir el camino a una afluencia mayor de mujeres en la música punk, poniendo así algunos temas feministas en primera línea. De este modo, trataremos de ampliar el ámbito de estudio del punk. Tanto su autobiografía Violence Girl, From East L.A. Rage to Hollywood Stage (2011 y su casi recién estrenado LP Alice Bag (2016 abarcan temas relacionados con la condición de las mujeres chicanas, convirtiendo al punk en una poderosa plataforma de la que se ayuda para articular conceptos feministas y étnicos.

  12. Effective ultraviolet irradiation of platelet concentrates in teflon bags

    International Nuclear Information System (INIS)

    Capon, S.M.; Sacher, R.A.; Deeg, H.J.

    1990-01-01

    Several plastic materials used in blood storage were evaluated for their ability to transmit ultraviolet B (UVB) light. A plastic bag manufactured from sheets of transparent Teflon efficiently (78-86%) transmitted UVB light and was employed in subsequent functional studies of lymphocytes and platelets exposed to UVB light while contained in these bags. In vitro experiments showed a UVB dose-dependent abrogation of lymphocyte responder and stimulator functions, with concurrent preservation of platelet aggregation responses. In a phase I pilot study, UVB-treated platelet concentrates were administered to four bone marrow transplant recipients. Adverse effects attributable to the transfusions were not observed, and patients showed clinically effective transfusion responses. No patient developed lymphocytotoxic HLA or platelet antibodies. These studies suggest that platelets can be effectively irradiated with UVB light in a closed system. However, numerous variables, including container material, volume and composition of contents, steady exposure versus agitation, and exact UV wavelength, must be considered

  13. Purple Urine Bag Syndrome: A Rare Spot Diagnosis

    Directory of Open Access Journals (Sweden)

    Dilraj S. Kalsi

    2017-01-01

    Full Text Available Purple urine bag syndrome (PUBS is a complication of urinary tract infections (UTIs where catheter bags and tubing turn purple. It is alarming for patients, families, and clinicians; however, it is in itself a benign phenomenon. PUBS is the result of UTIs with specific bacteria that produce sulphatases and phosphatases which lead tryptophan metabolism to produce indigo (blue and indirubin (red pigments, a mixture of which becomes purple. Risk factors include female gender, immobility, constipation, chronic catheterisation, and renal disease. Management involves reassurance, antibiotics, and regular changing of catheters, although there are debates regarding how aggressively to treat and no official guidelines. Prognosis is good, but PUBS is associated with high morbidity and mortality due to the backgrounds of patients. Here, we review the literature available on PUBS, present a summary of case studies from the last five years, and propose the Oxford Urine Chart as a tool to aid such diagnoses.

  14. Are ''anomalons'' a bag ful'o colorful nucleons

    International Nuclear Information System (INIS)

    Kruse, F.; Noack, C.C.

    1983-01-01

    One of the more intriguing explanations of the possible existence of ''anomalons'' (if they do exist) would seem to be in terms of internal color excitations of nuclei. While it follows from confinement in QCD that isolated nuclei (as well as isolated nucleons) must be in color singlet states, the same is not necessarily so for nucleons bound together in a small region of space, viz. a nucleus. Thus one can envisage a nucleus in a color-excited state as composed of localized 3q-systems (i.e. nucleons) which, however, are not all color singlets. We have investigated a particularly simple example of such a model which retains as many of the features of ''normal'' nuclei as possible, and at the same time stays close to the physical picture of the M.I.T. bag model. We call this a ''nuclear bag.''

  15. Regionally differentiated air pollution control regulations in the installation-related emission control law of the Federal Republic of Germany

    International Nuclear Information System (INIS)

    Buettner, T.W.

    1992-01-01

    The volume treats an issue from the boundary zone between environmental law and environmental economics, namely the regionalization of air pollution control standards in installation-related emission control law. In order to examine the question of whether this proposal, which originates in the field of environmental economics, can be adopted and is purposeful, the author initially performs a complete inventorization of applicable norms, this covering emission control law, the law of regional planning, and the provisions of international law. This status quo is then reviewed using conformity and optimization criteria developed by the political sciences. The assessment comes to the conclusion that the introduction of regionally differentiated air pollution control standards is not desirable. The author further submits proposals for the streamlining of the law of installation-related air pollution control in the Federal Republic of Germany. (orig.) [de

  16. Quark matter revisited with non-extensive MIT bag model

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Pedro H.G.; Nunes da Silva, Tiago; Menezes, Debora P. [Universidade Federal de Santa Catarina, Departamento de Fisica, CFM, Florianopolis (Brazil); Deppman, Airton [Instituto de Fisica da Universidade de Sao Paulo, Sao Paulo (Brazil)

    2017-10-15

    In this work we revisit the MIT bag model to describe quark matter within both the usual Fermi-Dirac and the Tsallis statistics. We verify the effects of the non-additivity of the latter by analysing two different pictures: the first order phase transition of the QCD phase diagram and stellar matter properties. While the QCD phase diagram is visually affected by the Tsallis statistics, the resulting effects on quark star macroscopic properties are barely noticed. (orig.)

  17. The 'silent' phase transition in mesonic bags and lattice theory

    International Nuclear Information System (INIS)

    Dey, J.; Dey, M.; Araujo Junior, C.F. de; Tomio, L.

    1993-10-01

    It is shown that even the simple bag model is able to reproduce the lattice result for the masses and the sound velocity, at finite temperature, T, suggests that the transition point depends on the nature of the meson. It would be interesting to check the last conclusion in present day finite temperature lattice theory, since different transition points seem to be indicated by particle emission T in heavy ion reactions. (author)

  18. Fermion Bag Approach to Lattice Hamiltonian Field Theories

    Science.gov (United States)

    Huffman, Emilie

    2018-03-01

    Using a model in the Gross-Neveu Ising universality class, we show how the fermion bag idea can be applied to develop algorithms to Hamiltonian lattice field theories. We argue that fermion world lines suggest an alternative method to the traditional techniques for calculating ratios of determinants in a stable manner. We show the power behind these ideas by extracting the physics of the model on large lattices.

  19. Quark bags, P-matrix and nucleon-nucleon scattering

    International Nuclear Information System (INIS)

    Narodetskij, I.M.

    1984-01-01

    This paper is an extended version of the talk given at IX European Conference on Few Body Problems in Physics, Tbilisi, 1984. It reviews recent developments of the quark compound bag (QCB) model including explicit examples of the QCB nucleon-nucleon potentials, description of the deuteron properties, calculation of the six quark admixture in the deuteron and applications to the three-nucleon system

  20. Exclusive semileptonic B decays in the bag model

    International Nuclear Information System (INIS)

    Lie-Svendsen, Oe.

    1989-09-01

    Using a recoil corrected version of the MIT bag model, the author has computed the relevant form factors and decay rates for the exclusive semileptonic decays B→De anti ν e and B→D*e anti ν e. The results are similar to other quark model calculations, but it is shown that the D* mode is suppressed due to the influence of the spectator quark. The D*'s produced are almost unpolarized in this model